PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Ornithine	240-249	CCAAT enhancer binding protein beta	Homo sapiens	70-75
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Ornithine	240-249	HNF1 homeobox A	Homo sapiens	80-85
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Ornithine	240-249	albumin	Homo sapiens	121-128
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Ornithine	5-14	albumin	Homo sapiens	43-50
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Ornithine	5-14	CCAAT enhancer binding protein beta	Homo sapiens	107-112
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Ornithine	5-14	CCAAT enhancer binding protein alpha	Homo sapiens	177-186
32216867-11	2020	A Lrp-like regulator (smc03092) divergently transcribed from argI1 was required for arginase induction by arginine or ornithine.	Ornithine	118-127	arginase	Sinorhizobium meliloti 1021	61-66
32597331-1	2021	Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine.	Ornithine	71-80	ornithine decarboxylase 1	Homo sapiens	96-99
32094585-3	2020	Here, we show that ornithine capture by the ribosome and the nascent peptide SpeFL controls polyamine synthesis in gamma-proteobacteria by inducing the expression of the ornithine decarboxylase SpeF4, via a mechanism involving ribosome stalling and transcription antitermination.	Ornithine	19-28	ornithine decarboxylase 1	Homo sapiens	170-193
32647818-1	2020	Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea.	Ornithine	99-110	arginase 1	Homo sapiens	0-10
32155745-2	2020	In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known.	Ornithine	50-61	ornithine decarboxylase 1	Homo sapiens	65-88
32155745-2	2020	In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known.	Ornithine	50-61	ornithine decarboxylase 1	Homo sapiens	90-93
32155745-2	2020	In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known.	Ornithine	50-61	ornithine decarboxylase 1	Homo sapiens	111-114
31933109-4	2020	Interconversion of proline, ornithine, and glutamate may therefore regulate PRODH/POX-dependent apoptosis/autophagy.	Ornithine	28-37	proline dehydrogenase 1	Homo sapiens	76-81
31933109-4	2020	Interconversion of proline, ornithine, and glutamate may therefore regulate PRODH/POX-dependent apoptosis/autophagy.	Ornithine	28-37	proline dehydrogenase 1	Homo sapiens	82-85
22649802-7	1993	DIAGNOSIS/TESTING: HHH syndrome is caused by mutation of SLC25A15, the gene that encodes ORNT1 (mitochondrial ornithine transporter 1), which is involved in the urea cycle and the ornithine degradation pathway.	Ornithine	110-119	solute carrier family 25 member 15	Homo sapiens	57-65
22649802-7	1993	DIAGNOSIS/TESTING: HHH syndrome is caused by mutation of SLC25A15, the gene that encodes ORNT1 (mitochondrial ornithine transporter 1), which is involved in the urea cycle and the ornithine degradation pathway.	Ornithine	110-119	solute carrier family 25 member 15	Homo sapiens	89-94
31287209-4	2020	G9a and GLP can also catalyze AdoSeEth-mediated ethylation of ornithine and produce histone peptides bearing lysine residues with different alkyl groups, such as H3K9meet and H3K9me2et.	Ornithine	62-71	euchromatic histone lysine methyltransferase 1	Homo sapiens	8-11
31777959-6	2020	In vivo and in vitro CFB upregulated arginase 1 (ARG1) expression, increased ARG1 enzymatic activity, and stimulated the syntheses of ornithine, leading to polyamine overproduction in macrophages.	Ornithine	134-143	complement factor B	Mus musculus	21-24
31362455-5	2019	Forty fungal isolates were screened for ODC production, twenty fungal isolates have the higher potency to grow on L-ornithine as sole nitrogen source.	Ornithine	114-125	ornithine decarboxylase 1	Homo sapiens	40-43
32110345-6	2019	A beta or gamma turn was favoured for Z = Dab, Orn or Glu due to a chi1 gauche (+) rotamer, while an alpha turn was favoured for Z = Dap (but not X = Dap) due to a gauche (-) rotamer.	Ornithine	47-50	amyloid beta precursor protein	Homo sapiens	0-6
31509528-0	2019	Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase.	Ornithine	83-92	antizyme inhibitor 2 S homeolog	Xenopus laevis	46-53
31509528-0	2019	Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase.	Ornithine	83-92	antizyme inhibitor 2 S homeolog	Xenopus laevis	54-60
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Ornithine	154-165	ornithine decarboxylase 1 L homeolog	Xenopus laevis	26-32
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Ornithine	154-165	antizyme inhibitor 1 L homeolog	Xenopus laevis	37-44
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Ornithine	154-165	antizyme inhibitor 2 S homeolog	Xenopus laevis	202-209
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Ornithine	154-165	antizyme inhibitor 2 S homeolog	Xenopus laevis	210-216
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Ornithine	154-165	antizyme inhibitor 2	Mus musculus	204-209
31093850-12	2019	The ornithine/arginine and ornithine/citrulline ratios were increased in CD73-/- compared to controls.	Ornithine	4-13	5' nucleotidase, ecto	Mus musculus	73-77
31093850-12	2019	The ornithine/arginine and ornithine/citrulline ratios were increased in CD73-/- compared to controls.	Ornithine	27-36	5' nucleotidase, ecto	Mus musculus	73-77
31509528-7	2019	xlAZIN2 did not behave as an antizyme inhibitor, but it rather acts as an authentic decarboxylase forming cadaverine, due to its higher affinity to L-lysine than to L-ornithine as substrate; so, in accordance with this, it should be named as lysine decarboxylase (LDC) or lysine/ornithine decarboxylase (LODC).	Ornithine	165-176	antizyme inhibitor 2 S homeolog	Xenopus laevis	0-7
31509528-9	2019	Collectively, our results indicate that in Xenopus there is only one antizyme inhibitor (xlAZIN1) and two decarboxylases, xlODC1 and xlLDC, with clear preferences for L-ornithine and L-lysine, respectively.	Ornithine	167-178	antizyme inhibitor 1 L homeolog	Xenopus laevis	89-96
31509528-9	2019	Collectively, our results indicate that in Xenopus there is only one antizyme inhibitor (xlAZIN1) and two decarboxylases, xlODC1 and xlLDC, with clear preferences for L-ornithine and L-lysine, respectively.	Ornithine	167-178	ornithine decarboxylase 1 L homeolog	Xenopus laevis	122-128
31362455-9	2019	The enzyme had a maximum activity at 37  C, pH 7.4-7.8 and thermal stability for 20 h at 37  C, and 90 days storage stability at 4  C. A. terreus ODC had a maximum affinity (Km) for l-ornithine, l-lysine and l-arginine (0.95, 1.34 and 1.4 mM) and catalytic efficiency (kcat/Km) (4.6, 2.83, 2.46 x 10-5 mM-1 s-1).	Ornithine	182-193	ornithine decarboxylase 1	Homo sapiens	146-149
30823619-7	2019	As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively.	Ornithine	81-90	RFI	Gallus gallus	127-130
31354664-0	2019	Competitive Repression of the artPIQM Operon for Arginine and Ornithine Transport by Arginine Repressor and Leucine-Responsive Regulatory Protein in Escherichia coli.	Ornithine	62-71	arginine repressor	Escherichia coli	85-103
30890279-1	2019	AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea.	Ornithine	50-61	arginase 1	Homo sapiens	5-15
30890279-1	2019	AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea.	Ornithine	50-61	arginase 1	Homo sapiens	17-22
30926170-1	2019	l-Ornithine is found in animals as a free amino acid and is a vital component of the urea cycle in the liver; it is reported to have various functions such as promoting wound healing, promoting growth hormone secretion, hypnotic effects, and so on.	Ornithine	0-11	growth hormone	Mus musculus	194-208
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Ornithine	163-172	transformation related protein 73	Mus musculus	17-22
30593514-7	2019	Mechanistically, TAp73 modifies the proline regulatory axis through regulation of enzymes GLS, OAT, and PYCR1 involved in the interconversion of proline-glutamine-ornithine.	Ornithine	163-172	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-109
30665936-1	2019	Arginase (Arg) 1 is expressed by hematopoietic (e.g., macrophages) and nonhematopoietic cells (e.g., endothelial cells) and converts l-arginine into ornithine and urea.	Ornithine	149-158	arginase, liver	Mus musculus	0-16
30957963-5	2019	These changes are consistent with the spectroscopic and kinetic results, indicating that the variant, as compared with the wild-type OAT, shows (a) an increased Km value for l-ornithine (l-Orn), (b) an altered pyridoxal 5"-phosphate binding mode and affinity and (c) an increased thermostability.	Ornithine	174-185	ornithine aminotransferase, mitochondrial	Cricetulus griseus	133-136
30957963-5	2019	These changes are consistent with the spectroscopic and kinetic results, indicating that the variant, as compared with the wild-type OAT, shows (a) an increased Km value for l-ornithine (l-Orn), (b) an altered pyridoxal 5"-phosphate binding mode and affinity and (c) an increased thermostability.	Ornithine	187-192	ornithine aminotransferase, mitochondrial	Cricetulus griseus	133-136
30957963-7	2019	Overall, these data indicate that the slight structural changes caused by the R180T mutation, preventing a proper collocation of l-Orn at the active site of OAT, are responsible for the notable reduction of the catalytic efficiency.	Ornithine	129-134	ornithine aminotransferase, mitochondrial	Cricetulus griseus	157-160
31098404-5	2019	L-Ornithine increases the level of aryl hydrocarbon receptor ligand L-kynurenine produced from tryptophan metabolism in gut epithelial cells, which in turn increases RORgammat (+)IL-22(+) ILC3 cells.	Ornithine	0-11	interleukin 22	Homo sapiens	179-184
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	60-71	regenerating family member 3 alpha	Homo sapiens	6-11
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	60-71	regenerating islet-derived 3 alpha	Mus musculus	147-152
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	177-188	regenerating family member 3 alpha	Homo sapiens	6-11
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	177-188	regenerating islet-derived 3 alpha	Mus musculus	147-152
30659259-5	2019	SLC7A2 was associated with the plasma levels of arginine and ornithine, and PKD1L2 with the level of glycine.	Ornithine	61-70	solute carrier family 7 member 2	Homo sapiens	0-6
30832686-1	2019	BACKGROUND: y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal and renal tubular cells.	Ornithine	193-202	solute carrier family 7 member 7	Homo sapiens	12-18
30553157-10	2019	Docking into the active site of folate receptor-alpha predicts a similar best binding pose for four of the ligands, which requires stretching of pterin and bending of glutamate/ornithine relative to the geometry in saline.	Ornithine	177-186	folate receptor alpha	Homo sapiens	32-53
30146690-5	2019	Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance.	Ornithine	89-98	insulin	Homo sapiens	195-202
30759381-4	2019	While cancer cells exclusively use ARG2, normal epithelial cells synthesize ornithine via ornithine aminotransferase (OAT).	Ornithine	76-85	ornithine aminotransferase	Homo sapiens	90-116
30634588-6	2019	Results: Our results showed that serum putrescine, directly generated from ornithine by the catalytic action of the biosynthetic enzyme ornithine decarboxylase, was significantly elevated in patients with T2D compared to those without T2D, and that it significantly correlated with the levels of glycosylated hemoglobin (HbA1c).	Ornithine	75-84	ornithine decarboxylase 1	Homo sapiens	136-159
30706424-2	2019	L-ornithine serves as an intermediary in the urea cycle in periportal hepatocytes in the liver and as an activator of carbamoyl phosphate synthetase, and, like L-aspartate, by transamination to glutamate via glutamine synthetase in perivenous hepatocytes as well as by skeletal muscle and brain.	Ornithine	0-11	glutamate-ammonia ligase	Homo sapiens	208-228
30486347-4	2018	INH/RFP was found to disrupt fatty acid metabolism, the tricarboxylic acid cycle, amino acid metabolism, taurine metabolism, and the ornithine cycle.	Ornithine	133-142	tripartite motif-containing 27	Mus musculus	4-7
30513923-3	2018	In this study, we hypothesized that a composite supplement containing fish derived-collagen peptide and ornithine (CPO) could improve skin conditions by increasing plasma growth hormone and/or insulin-like growth factor-1 (IGF-1) levels.	Ornithine	104-113	growth hormone 1	Homo sapiens	171-185
30513923-3	2018	In this study, we hypothesized that a composite supplement containing fish derived-collagen peptide and ornithine (CPO) could improve skin conditions by increasing plasma growth hormone and/or insulin-like growth factor-1 (IGF-1) levels.	Ornithine	104-113	insulin like growth factor 1	Homo sapiens	223-228
29944916-9	2018	Among others, alpha-ketoglutarate, hydroxyglutarate and certain amino acids (ornithine, proline and glycine) were reduced in the CS patient fibroblasts, whereas glycolytic intermediates (glucose-6-phosphate and pyruvic acid) and fatty acids (palmitic, stearic and myristic acid) were increased.	Ornithine	77-86	citrate synthase	Homo sapiens	129-131
30251682-2	2018	GA is caused by point mutations in the gene encoding ornithine delta-aminotransferase (OAT), a tetrameric pyridoxal 5"-phosphate-dependent enzyme catalysing the transamination of l-ornithine and alpha-ketoglutarate to glutamic-gamma-semialdehyde and l-glutamate in mitochondria.	Ornithine	179-190	ornithine aminotransferase	Homo sapiens	53-85
30429607-8	2018	Serum proteomic analysis identified the arginine-degrading enzyme arginase I (ARG1) in the circulation of Atg7-deficient hosts, and in vivo arginine metabolic tracing demonstrated that serum arginine was degraded to ornithine.	Ornithine	216-225	arginase, liver	Mus musculus	66-76
30429607-8	2018	Serum proteomic analysis identified the arginine-degrading enzyme arginase I (ARG1) in the circulation of Atg7-deficient hosts, and in vivo arginine metabolic tracing demonstrated that serum arginine was degraded to ornithine.	Ornithine	216-225	arginase, liver	Mus musculus	78-82
30021117-1	2018	Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis.	Ornithine	42-51	ornithine decarboxylase 1	Homo sapiens	0-23
30066894-9	2018	It was postulated that the accumulated ornithine could be channeled via ODC1 to produce polyamines that promoted tumour growth.	Ornithine	39-48	ornithine decarboxylase 1	Homo sapiens	72-76
30403179-3	2018	In this study, we have investigated the effect of SLC25A15, which encodes the mitochondrial ornithine carrier 1, on melanoma progression.	Ornithine	92-101	solute carrier family 25 member 15	Homo sapiens	50-58
30021117-1	2018	Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis.	Ornithine	42-51	ornithine decarboxylase 1	Homo sapiens	25-28
30021117-4	2018	Here, to increase ODC substrate specificity toward ornithine over lysine, molecular modelling and protein network analysis, specifically k-clique community analysis, around the substrate tunnel were performed.	Ornithine	51-60	ornithine decarboxylase 1	Homo sapiens	18-21
29601948-10	2018	Moreover, AR, ADRB2, and OAZ3 might be targets of spironolactone, trimipramine, and L-ornithine in the treatment of obese PCOS.	Ornithine	84-95	androgen receptor	Homo sapiens	10-12
29601948-10	2018	Moreover, AR, ADRB2, and OAZ3 might be targets of spironolactone, trimipramine, and L-ornithine in the treatment of obese PCOS.	Ornithine	84-95	adrenoceptor beta 2	Homo sapiens	14-19
29601948-10	2018	Moreover, AR, ADRB2, and OAZ3 might be targets of spironolactone, trimipramine, and L-ornithine in the treatment of obese PCOS.	Ornithine	84-95	ornithine decarboxylase antizyme 3	Homo sapiens	25-29
29150896-4	2018	The stereospecific effect in CID of the trans-cO residue is explained by syn-facially directed proton transfer from the 4-ammonium group at cO to the C-terminal amide followed by neighboring group participation in the cleavage of the CO-NH bond, analogous to the aspartic acid and ornithine effects.	Ornithine	281-290	synemin	Homo sapiens	73-76
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Ornithine	41-50	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Ornithine	41-50	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Ornithine	41-50	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119
29427946-2	2018	More specifically, acryloyl derivatives of lysine, ornithine, cystine and cystamine, were employed as monomers and disulfide crosslinkers for non-covalent encapsulation of model protein bovine serum albumin (BSA) and were interfacially crosslinked via free radical polymerization to form redox-responsive protein NPs.	Ornithine	51-60	albumin	Homo sapiens	193-206
29240458-9	2018	These targeted DEMs were significantly enriched in D-Arginine and D-ornithine metabolism and glycerolipid metabolism of Kyoto Encyclopedia of Genes and Genomes pathways, and enriched in bradykinin receptor activity and haptoglobin binding of gene ontology biological processes.	Ornithine	66-77	kininogen 1	Homo sapiens	186-196
29282796-1	2018	The ornithine transcarbamylase (OTC) gene is on the X chromosome and its product catalyzes the formation of citrulline from ornithine and carbamylphosphate in the urea cycle.	Ornithine	4-13	ornithine transcarbamylase	Homo sapiens	32-35
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Ornithine	59-68	arginase 1	Homo sapiens	103-113
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Ornithine	59-68	arginase 2	Homo sapiens	118-128
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Ornithine	70-73	arginase 1	Homo sapiens	103-113
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Ornithine	70-73	arginase 2	Homo sapiens	118-128
29419804-1	2018	The fluorinated ornithine analog alpha-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.	Ornithine	16-25	ornithine decarboxylase 1	Homo sapiens	133-156
29419804-1	2018	The fluorinated ornithine analog alpha-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.	Ornithine	16-25	ornithine decarboxylase 1	Homo sapiens	158-161
29450408-3	2018	In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nomega-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice.	Ornithine	40-49	arginase, liver	Mus musculus	93-103
29410783-3	2018	In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine.	Ornithine	61-70	ornithine decarboxylase	Ovis aries	129-133
29080161-5	2018	We describe the methodology employed for the determination of ODC and ADC activities in plant tissues by detecting the release of (C14) CO2 using (C14) labelled substrates (ornithine or arginine).	Ornithine	173-182	ornithine decarboxylase 1	Homo sapiens	62-65
28679527-1	2017	Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival.	Ornithine	98-107	ornithine decarboxylase 1	Homo sapiens	133-156
27989597-1	2017	Vertebrate ALDH18A1 genes encode a bifunctional mitochondrial enzyme, catalyzing a 2-step conversion of glutamate to glutamyl semialdehyde, subsequently converted into proline, ornithine and arginine.	Ornithine	177-186	aldehyde dehydrogenase 18 family, member A1	Rattus norvegicus	11-19
29187192-9	2017	Identified metabolites were related to the bradykinin system, involved in oxidative stress (e.g., glutamine or pipecolate) or linked to the urea cycle (e.g., ornithine or citrulline).	Ornithine	158-167	kininogen 1	Homo sapiens	43-53
28708224-2	2017	CASE REPORT: We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet.	Ornithine	91-100	ornithine aminotransferase	Homo sapiens	57-61
28722259-0	2017	l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.	Ornithine	0-11	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-105
28722259-5	2017	Moreover, the stimulatory effect of Orn and Lys was abolished in TRPV1-knockout mice.	Ornithine	36-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
28679527-1	2017	Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival.	Ornithine	98-107	ornithine decarboxylase 1	Homo sapiens	158-161
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Ornithine	161-170	solute carrier family 7 member 2	Homo sapiens	0-33
29254168-5	2017	Targeted metabolomics including 24 metabolites revealed that most tricarboxylic acid (TCA) cycle intermediates, aspartate-derived asparagine, alanine and ornithine-derived polyamines were strongly down-regulated in SLC25A22 knockdown cells.	Ornithine	154-163	solute carrier family 25 member 22	Homo sapiens	215-223
29254168-6	2017	Moreover, targeted kinetic isotope analysis showed that most of the 13C-labeled ornithine-derived polyamines were significantly decreased in SLC25A22 knockdown cells and culture medium.	Ornithine	80-89	solute carrier family 25 member 22	Homo sapiens	141-149
28294536-9	2017	The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation.	Ornithine	115-124	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	34-38
28294536-9	2017	The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation.	Ornithine	115-124	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	39-43
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Ornithine	161-170	solute carrier family 7 member 2	Homo sapiens	35-41
28272331-4	2017	In general, OAT serves to form glutamate from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine (Arg) are end products.	Ornithine	46-55	ornithine aminotransferase	Homo sapiens	12-15
28695314-8	2017	Competence of SlCAT2 for Arg transport was demonstrated measuring uptake of [3H]Arg in proteoliposomes which was trans-stimulated by internal Arg or ornithine.	Ornithine	149-158	catalase isozyme 2	Solanum lycopersicum	14-20
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	60-65	ghrelin and obestatin prepropeptide	Rattus norvegicus	119-126
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	146-151	ghrelin and obestatin prepropeptide	Rattus norvegicus	119-126
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	146-151	ghrelin and obestatin prepropeptide	Rattus norvegicus	119-126
28513740-3	2017	Intraduodenally administered l-Orn increased ghrelin mRNA expression in the duodenum but not in the stomach or hypothalamus.	Ornithine	29-34	ghrelin and obestatin prepropeptide	Rattus norvegicus	45-52
28513740-4	2017	In addition, l-Orn-induced GH-releasing activity was inhibited by propranolol, an antagonist of beta-adrenergic receptor, which is known to be coupled to ghrelin release.	Ornithine	13-18	gonadotropin releasing hormone receptor	Rattus norvegicus	27-29
28513740-4	2017	In addition, l-Orn-induced GH-releasing activity was inhibited by propranolol, an antagonist of beta-adrenergic receptor, which is known to be coupled to ghrelin release.	Ornithine	13-18	ghrelin and obestatin prepropeptide	Rattus norvegicus	154-161
28513740-5	2017	In conclusion, intraduodenally administered l-Orn stimulates GH secretion through the sympathetic nervous and ghrelin systems.	Ornithine	44-49	gonadotropin releasing hormone receptor	Rattus norvegicus	61-63
28513740-5	2017	In conclusion, intraduodenally administered l-Orn stimulates GH secretion through the sympathetic nervous and ghrelin systems.	Ornithine	44-49	ghrelin and obestatin prepropeptide	Rattus norvegicus	110-117
28587687-3	2017	In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine.	Ornithine	84-93	ornithine decarboxylase 1	Homo sapiens	122-145
28587687-3	2017	In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine.	Ornithine	84-93	ornithine decarboxylase 1	Homo sapiens	147-151
28587687-7	2017	Additionally, proline is oxidized by proline oxidase to yield pyrroline-5-carboxylate, which undergoes transamination with glutamate to produce ornithine for decarboxylation by ODC1.	Ornithine	144-153	ornithine decarboxylase 1	Homo sapiens	177-181
28808255-4	2017	We find that the mitochondrial form of arginase (ARG2), which hydrolyzes arginine into ornithine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses PDA.	Ornithine	87-96	arginase 2	Homo sapiens	49-53
28513740-0	2017	l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system.	Ornithine	0-11	gonadotropin releasing hormone receptor	Rattus norvegicus	23-37
28513740-0	2017	l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system.	Ornithine	0-11	ghrelin and obestatin prepropeptide	Rattus norvegicus	75-82
28513740-1	2017	We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism.	Ornithine	46-57	gonadotropin releasing hormone receptor	Rattus norvegicus	77-91
28513740-1	2017	We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism.	Ornithine	46-57	gonadotropin releasing hormone receptor	Rattus norvegicus	93-95
28513740-1	2017	We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism.	Ornithine	59-64	gonadotropin releasing hormone receptor	Rattus norvegicus	77-91
28513740-1	2017	We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism.	Ornithine	59-64	gonadotropin releasing hormone receptor	Rattus norvegicus	93-95
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	60-65	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	60-65	growth hormone secretagogue receptor	Rattus norvegicus	119-135
28513740-2	2017	GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 muM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor.	Ornithine	60-65	gonadotropin releasing hormone receptor	Rattus norvegicus	90-92
27943578-4	2017	We found that oral administration of both L-arginine and L-ornithine significantly increased total plasma GLP-1 levels to a similar level in GPRC6A KO and WT mice 15 minutes after gavage (both amino acids) and accumulated up to 60 minutes after gavage (L-arginine).	Ornithine	57-68	glucagon	Mus musculus	106-111
27943578-4	2017	We found that oral administration of both L-arginine and L-ornithine significantly increased total plasma GLP-1 levels to a similar level in GPRC6A KO and WT mice 15 minutes after gavage (both amino acids) and accumulated up to 60 minutes after gavage (L-arginine).	Ornithine	57-68	G protein-coupled receptor, family C, group 6, member A	Mus musculus	141-147
27943578-7	2017	In addition, this is the first study to show that also L-ornithine powerfully elicits GLP-1 release in vivo.	Ornithine	55-66	glucagon	Mus musculus	86-91
28270654-8	2017	An ornithine metabolism imbalance resulting from overexpression of Aurora Kinase A as a result of a single, recurrent heterozygous deletion on chromosome 19, common to all fibrolamellar carcinomas, can lead to a c-Myc and ornithine decarboxylase overexpression that results in ornithine transcarboxylase dysfunction with urea cycle disorder and subsequent hyperammonemia.	Ornithine	3-12	aurora kinase A	Homo sapiens	67-82
28270654-8	2017	An ornithine metabolism imbalance resulting from overexpression of Aurora Kinase A as a result of a single, recurrent heterozygous deletion on chromosome 19, common to all fibrolamellar carcinomas, can lead to a c-Myc and ornithine decarboxylase overexpression that results in ornithine transcarboxylase dysfunction with urea cycle disorder and subsequent hyperammonemia.	Ornithine	3-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	212-217
28270654-8	2017	An ornithine metabolism imbalance resulting from overexpression of Aurora Kinase A as a result of a single, recurrent heterozygous deletion on chromosome 19, common to all fibrolamellar carcinomas, can lead to a c-Myc and ornithine decarboxylase overexpression that results in ornithine transcarboxylase dysfunction with urea cycle disorder and subsequent hyperammonemia.	Ornithine	3-12	ornithine decarboxylase 1	Homo sapiens	222-245
28137860-3	2017	Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: the transfer of an amidino group from arginine to glycine to form ornithine and guanidinoacetate.	Ornithine	159-168	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	Mus musculus	28-32
27998825-2	2017	Arg1 uses the substrate l-arginine to create l-ornithine, a precursor molecule required for collagen formation and vascular smooth muscle cell differentiation.	Ornithine	45-56	arginase, liver	Mus musculus	0-4
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Ornithine	212-221	solute carrier family 3 member 1	Homo sapiens	97-103
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Ornithine	212-221	solute carrier family 7 member 9	Homo sapiens	108-114
29332900-1	2017	Brain protein synthesis and the plasma concentration of growth hormone (GH) are sensitive to dietary ornithine.	Ornithine	101-110	gonadotropin releasing hormone receptor	Rattus norvegicus	56-70
29332900-1	2017	Brain protein synthesis and the plasma concentration of growth hormone (GH) are sensitive to dietary ornithine.	Ornithine	101-110	gonadotropin releasing hormone receptor	Rattus norvegicus	72-74
29332900-5	2017	The plasma concentrations of GH and ghrelin, and the fractional rates of protein synthesis and RNA activity [g protein synthesized/(g RNA d)] in the brains were significantly increased after treatment with the 20% casein + 0.7% ornithine compared with the 20% casein diet alone in both the PTU-treated and control groups.	Ornithine	228-237	gonadotropin releasing hormone receptor	Rattus norvegicus	29-31
29332900-8	2017	The results suggest that dietary ornithine likely increases the rate of brain protein synthesis in control and PTU-treated rats, and that the ornithine-induced increase in the GH concentration may stimulate mainly brain protein synthesis via ghrelin.	Ornithine	142-151	gonadotropin releasing hormone receptor	Rattus norvegicus	176-178
29332900-8	2017	The results suggest that dietary ornithine likely increases the rate of brain protein synthesis in control and PTU-treated rats, and that the ornithine-induced increase in the GH concentration may stimulate mainly brain protein synthesis via ghrelin.	Ornithine	142-151	ghrelin and obestatin prepropeptide	Rattus norvegicus	242-249
27941031-11	2016	Interestingly, a protein, termed antizyme inhibitor (AzI) that is highly homologous with ODC, but retains no ornithine decarboxylating activity, seems to regulate cellular polyamines through its ability to negate Az.	Ornithine	109-118	antizyme inhibitor 1	Homo sapiens	33-51
27941031-11	2016	Interestingly, a protein, termed antizyme inhibitor (AzI) that is highly homologous with ODC, but retains no ornithine decarboxylating activity, seems to regulate cellular polyamines through its ability to negate Az.	Ornithine	109-118	antizyme inhibitor 1	Homo sapiens	53-56
27761413-1	2016	Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver.	Ornithine	48-57	arginase, liver	Mus musculus	0-10
27761413-1	2016	Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver.	Ornithine	48-57	arginase, liver	Mus musculus	12-16
27497722-0	2016	Enantioselective determination of citrulline and ornithine in the urine of d-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system.	Ornithine	49-58	D-amino acid oxidase	Mus musculus	75-95
27303024-4	2016	The recombinant LcL/ODC preferentially catalyzed the decarboxylation of l-Lys over l-ornithine (l-Orn) by about 5 times.	Ornithine	83-94	ornithine decarboxylase-like	Nicotiana tabacum	20-23
27703199-5	2016	Here we demonstrate, using an in vivo monitoring system, that repeated oral administration of l-ornithine at an early inactive period in mice induced a phase advance in the rhythm of PER2 expression.	Ornithine	94-105	period circadian clock 2	Mus musculus	183-187
27703199-6	2016	By contrast, l-ornithine administration to mouse embryonic fibroblasts did not affect the expression of PER2, indicating that l-ornithine indirectly alters the phase of PER2.	Ornithine	126-137	period circadian clock 2	Mus musculus	169-173
27703199-7	2016	l-Ornithine also increased plasma levels of insulin, glucose and glucagon-like peptide-1 alongside mPer2 expression, suggesting that it exerts its effects probably via insulin secretion.	Ornithine	0-11	period circadian clock 2	Mus musculus	99-104
27402627-2	2016	Transposon insertions in an ornithine decarboxylase (odc) gene in Agrobacterium tumefaciens, predicted to direct synthesis of the polyamine putrescine from ornithine, resulted in elevated cellulose.	Ornithine	28-37	type III PLP-dependent enzyme	Agrobacterium tumefaciens	53-56
26898547-10	2016	Gamt(MUT) treated with both ornithine and PTX did not show electro-behavioral seizures while ornithine elevated the PTX seizure threshold of Gamt(MUT) mice even further.	Ornithine	93-102	guanidinoacetate methyltransferase	Mus musculus	141-145
26898547-12	2016	These findings are directly and clinically relevant for patients with a creatine-deficiency syndrome due to genetic defects in GAMT and provide a rational basis for a combined ornithine/picrotoxin therapeutic intervention.	Ornithine	176-185	guanidinoacetate N-methyltransferase	Homo sapiens	127-131
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Ornithine	100-109	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Ornithine	100-109	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
27479442-6	2016	Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours.	Ornithine	209-220	arginase 1	Homo sapiens	35-39
27479442-6	2016	Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours.	Ornithine	209-214	arginase 1	Homo sapiens	35-39
26898547-8	2016	Ornithine treatment and also PTX administration led to a relative normalization of the Gamt(MUT) ECoG phenotype.	Ornithine	0-9	guanidinoacetate methyltransferase	Mus musculus	87-91
26898547-10	2016	Gamt(MUT) treated with both ornithine and PTX did not show electro-behavioral seizures while ornithine elevated the PTX seizure threshold of Gamt(MUT) mice even further.	Ornithine	28-37	guanidinoacetate methyltransferase	Mus musculus	0-4
27303024-4	2016	The recombinant LcL/ODC preferentially catalyzed the decarboxylation of l-Lys over l-ornithine (l-Orn) by about 5 times.	Ornithine	96-101	ornithine decarboxylase-like	Nicotiana tabacum	20-23
27126795-1	2016	Silencing of ODC also led to significantly reduced concentrations of polyamines (putrescine, spermidine and spermine), tyramine and phenolamides (caffeoylputrescine and dicaffeoylspermidine) with concomitant increases in concentrations of amino acids ornithine, arginine, aspartate, glutamate and glutamine.	Ornithine	251-260	ornithine decarboxylase	Nicotiana tabacum	13-16
25952544-7	2016	As one of puerarin-upregulated proteins, mitochondrial arginase-2 hydrolyzes L-arginine to L-ornithine, thereby competing with neuronal NOS for substrate L-arginine in mitochondria.	Ornithine	91-102	arginase 2	Rattus norvegicus	55-65
26831650-2	2016	The arginine, one of the major amino acids in grape musts, is metabolized by arginase (encoded by CAR1) to ornithine and urea.	Ornithine	107-116	arginase	Saccharomyces cerevisiae S288C	98-102
26773858-10	2016	Further study demonstrated that the increase in ornithine level may result from the increased expression of arginase 2 in HUVECs, which mediates the hydrolysis of arginine to form ornithine.	Ornithine	48-57	arginase 2	Homo sapiens	108-118
26403849-3	2016	It was found that the recombinant, purified mitochondrial solute carrier SLC25A2 when reconstituted into liposomes efficiently transports ADMA in addition to its known substrates arginine, lysine, and ornithine and in contrast to the other known mitochondrial amino acid transporters SLC25A12, SLC25A13, SLC25A15, SLC25A18, SLC25A22, and SLC25A29.	Ornithine	201-210	solute carrier family 25 member 2	Homo sapiens	73-80
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Ornithine	92-101	arginase 1	Homo sapiens	0-10
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Ornithine	92-101	arginase 1	Homo sapiens	12-16
26940652-7	2016	The critical regulatory metabolites succinate, gamma-aminobutyric acid, arginine, ornithine and adenosine were increased in LPS-stimulated macrophages from young mice, but not macrophages from old mice.	Ornithine	82-91	toll-like receptor 4	Mus musculus	124-127
26773858-10	2016	Further study demonstrated that the increase in ornithine level may result from the increased expression of arginase 2 in HUVECs, which mediates the hydrolysis of arginine to form ornithine.	Ornithine	180-189	arginase 2	Homo sapiens	108-118
26589310-0	2016	Heterologous Expression in Yeast of Human Ornithine Carriers ORNT1 and ORNT2 and of ORNT1 Alleles Implicated in HHH Syndrome in Humans.	Ornithine	42-51	solute carrier family 25 member 15	Homo sapiens	61-66
25630515-2	2016	The effect of ornithine acetyltransferase (OATase; ArgJ) on l-ornithine production was investigated, and C. glutamicum 1006 was engineered to overproduce l-ornithine as a major product by inactivating regulatory repressor argR gene and overexpressing argJ gene.	Ornithine	60-71	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Corynebacterium glutamicum ATCC 13032	51-55
25630515-2	2016	The effect of ornithine acetyltransferase (OATase; ArgJ) on l-ornithine production was investigated, and C. glutamicum 1006 was engineered to overproduce l-ornithine as a major product by inactivating regulatory repressor argR gene and overexpressing argJ gene.	Ornithine	154-165	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Corynebacterium glutamicum ATCC 13032	251-255
25630515-5	2016	To enhance l-ornithine production, the argJ gene from C. glutamicum ATCC 13032 was overexpressed.	Ornithine	11-22	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Corynebacterium glutamicum ATCC 13032	39-43
25630515-6	2016	In flask cultures, the resulting strain, C. glutamicum 1006 argR-argJ, produced 31.6 g/L l-ornithine, which is 54.15% more than that produced by C. glutamicum 1006.	Ornithine	89-100	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Corynebacterium glutamicum ATCC 13032	65-69
25630515-8	2016	ArgJ strongly influences the production of l-ornithine in C. glutamicum.	Ornithine	43-54	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Corynebacterium glutamicum ATCC 13032	0-4
26971935-5	2016	Real-time PCR analysis revealed in APPwt cells significant decreases of ARG1 and ARG2 which are responsible for lysing arginine into ornithine and urea; this reduction was followed by significantly lower enzyme activity.	Ornithine	133-142	arginase 1	Homo sapiens	72-76
26971935-5	2016	Real-time PCR analysis revealed in APPwt cells significant decreases of ARG1 and ARG2 which are responsible for lysing arginine into ornithine and urea; this reduction was followed by significantly lower enzyme activity.	Ornithine	133-142	arginase 2	Homo sapiens	81-85
26971935-8	2016	Ornithine decarboxylase (ODC), which decarboxylates ornithine to form putrescine was also reduced.	Ornithine	52-61	ornithine decarboxylase 1	Homo sapiens	0-23
26971935-8	2016	Ornithine decarboxylase (ODC), which decarboxylates ornithine to form putrescine was also reduced.	Ornithine	52-61	ornithine decarboxylase 1	Homo sapiens	25-28
26589310-0	2016	Heterologous Expression in Yeast of Human Ornithine Carriers ORNT1 and ORNT2 and of ORNT1 Alleles Implicated in HHH Syndrome in Humans.	Ornithine	42-51	solute carrier family 25 member 2	Homo sapiens	71-76
26589310-5	2016	In yeast Saccharomyces cerevisiae the major function of the transporter (encoded by Arg11) is to shuttle ornithine from the mitochondrial matrix to the cytosol.	Ornithine	105-114	Ort1p	Saccharomyces cerevisiae S288C	84-89
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Ornithine	85-96	arginase 1	Homo sapiens	0-10
26467175-2	2015	This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ornithine and urea.	Ornithine	209-218	arginase, liver	Mus musculus	94-98
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Ornithine	85-96	arginase 2	Homo sapiens	15-25
26002808-4	2015	There are, however, marked differences in their substrate specificities including their affinity for ornithine (KM values in the mM to muM range).	Ornithine	101-110	latexin	Homo sapiens	135-138
26770910-0	2015	The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver.	Ornithine	14-25	CREB regulated transcription coactivator 1	Mus musculus	52-58
26770910-9	2015	The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver.	Ornithine	27-30	CREB regulated transcription coactivator 1	Mus musculus	80-86
26770910-9	2015	The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver.	Ornithine	27-30	CREB regulated transcription coactivator 1	Mus musculus	235-241
26770910-9	2015	The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver.	Ornithine	158-161	CREB regulated transcription coactivator 1	Mus musculus	80-86
26770910-9	2015	The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver.	Ornithine	158-161	CREB regulated transcription coactivator 1	Mus musculus	235-241
26358771-1	2015	Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine.	Ornithine	112-121	arginase 1	Homo sapiens	47-57
26358771-1	2015	Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine.	Ornithine	112-121	arginase 1	Homo sapiens	59-63
26002808-7	2015	In the liver, human ORC1 catalyzes the citrulline/ornithine exchange across the mitochondrial inner membrane, which is required for the urea cycle.	Ornithine	50-59	origin recognition complex subunit 1	Homo sapiens	20-24
26377079-8	2015	The uptake was Na+-independent, and was inhibited by L-ornithine, L-arginine, and L-lysine, suggesting the involvement of CAT1 in L-ornithine transport at the inner BRB.	Ornithine	53-64	solute carrier family 7 member 1	Rattus norvegicus	122-126
26093026-1	2015	Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine.	Ornithine	66-75	ornithine decarboxylase 1	Homo sapiens	91-94
26377079-8	2015	The uptake was Na+-independent, and was inhibited by L-ornithine, L-arginine, and L-lysine, suggesting the involvement of CAT1 in L-ornithine transport at the inner BRB.	Ornithine	130-141	solute carrier family 7 member 1	Rattus norvegicus	122-126
26377079-10	2015	Retinal pigment epithelium-J cells showed that the basal-to-cell (B-to-C) uptake of [3H]L-ornithine was greater than that of the apical-to-cell (A-to-C) uptake, and the B-to-C transport was inhibited by unlabeled L-ornithine, suggesting the involvement of CAT1 in the blood-to-cell transport of L-ornithine across the basal membrane at the outer BRB.	Ornithine	88-99	solute carrier family 7 member 1	Rattus norvegicus	256-260
26377079-11	2015	CONCLUSIONS: These suggest the involvement of CAT1 in L-ornithine transport at the luminal and abluminal sides of the inner BRB and the basal side of the outer BRB.	Ornithine	54-65	solute carrier family 7 member 1	Rattus norvegicus	46-50
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-57
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	59-63
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Ornithine	21-30	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
26284090-14	2015	Our study contributes to the functional characterization of P5CDH in biotic and abiotic stress conditions, by revealing its capacity to modulate the fate of P5C, and prevalence of Orn or Glu as Pro precursors in tissues that initially consumed Pro.	Ornithine	180-183	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	60-65
25683148-3	2015	Hepatocytes have galactokinase (GALK), which metabolizes galactose for gluconeogenesis, and ornithine transcarbamylase (OTC), which converts ornithine to arginine in the urea cycle.	Ornithine	92-101	ornithine transcarbamylase	Homo sapiens	120-123
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	86-95	acetylornithine deacetylase	Sinorhizobium meliloti 1021	134-138
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	86-95	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Sinorhizobium meliloti 1021	216-220
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	105-114	acetylornithine deacetylase	Sinorhizobium meliloti 1021	134-138
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	105-114	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Sinorhizobium meliloti 1021	216-220
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	105-114	acetylornithine deacetylase	Sinorhizobium meliloti 1021	134-138
26271664-3	2015	Unlike most bacteria, S. meliloti 1021 is annotated as encoding two enzymes producing ornithine: N-acetylornithine (NAO) deacetylase (ArgE) hydrolyses NAO to acetate and ornithine, and glutamate N-acetyltransferase (ArgJ) transacetylates l-glutamate with the acetyl group from NAO, forming ornithine and N-acetylglutamate (NAG).	Ornithine	105-114	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Sinorhizobium meliloti 1021	216-220
26271664-7	2015	The purified ArgJ was highly active in NAO deacetylation/glutamate transacetylation and was significantly inhibited by ornithine but not by arginine.	Ornithine	119-128	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Sinorhizobium meliloti 1021	13-17
25938595-1	2015	Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body.	Ornithine	51-60	arginase, liver	Mus musculus	0-10
25109415-15	2015	Patients with at least one missense mutation in SLC3A1 had significantly lower levels of lysine, arginine, and ornithine but not cystine than patients with all other combinations of mutations.	Ornithine	111-120	solute carrier family 3 member 1	Homo sapiens	48-54
25797592-4	2015	A strong correlation was also observed between HM and mRNA expression levels of arginase 1, an enzyme that catalyzes the conversion of arginine to ornithine.	Ornithine	147-156	arginase 1	Homo sapiens	80-90
24865414-7	2015	Biochemical analyses revealed that ESBL producers more frequently utilized inositol, ornithine, sorbitol, melibiose, and saccharose, whereas the control group more frequently used esculin, lysine, arginine, and dulcitol.	Ornithine	85-94	EsbL	Escherichia coli	35-39
25807386-4	2015	Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively.	Ornithine	36-45	ornithine decarboxylase, structural 1	Mus musculus	78-101
25807386-4	2015	Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively.	Ornithine	36-45	ornithine decarboxylase, structural 1	Mus musculus	103-106
25874378-5	2015	HHH syndrome is caused by impaired ornithine transport across the inner mitochondrial membrane due to mutations in SLC25A15 gene, which encodes for the mitochondrial ornithine carrier ORC1.	Ornithine	35-44	solute carrier family 25 member 15	Homo sapiens	115-123
25874378-5	2015	HHH syndrome is caused by impaired ornithine transport across the inner mitochondrial membrane due to mutations in SLC25A15 gene, which encodes for the mitochondrial ornithine carrier ORC1.	Ornithine	35-44	origin recognition complex subunit 1	Homo sapiens	184-188
25874378-5	2015	HHH syndrome is caused by impaired ornithine transport across the inner mitochondrial membrane due to mutations in SLC25A15 gene, which encodes for the mitochondrial ornithine carrier ORC1.	Ornithine	166-175	solute carrier family 25 member 15	Homo sapiens	115-123
25874378-5	2015	HHH syndrome is caused by impaired ornithine transport across the inner mitochondrial membrane due to mutations in SLC25A15 gene, which encodes for the mitochondrial ornithine carrier ORC1.	Ornithine	166-175	origin recognition complex subunit 1	Homo sapiens	184-188
25286138-0	2015	Effects of time of L-ornithine administration on the diurnal rhythms of plasma growth hormone, melatonin, and corticosterone levels in mice.	Ornithine	19-30	growth hormone	Mus musculus	79-93
25286138-2	2015	Oral administration of several nutritional factors, including L-ornithine, modulates these hormonal secretions and induces an acute increase in plasma GH levels.	Ornithine	62-73	growth hormone	Mus musculus	151-153
25286138-4	2015	In this study, we evaluated whether the diurnal rhythms of plasma GH, melatonin, and corticosterone secretion were altered by the daily administration of L-ornithine as well as the timing of the administration, in CBA/N mice.	Ornithine	154-165	growth hormone	Mus musculus	66-68
25286138-5	2015	Our results showed that the plasma GH levels that peaked at light phase were amplified by L-ornithine (500 mg/kg) administered at Zeitgeber time (ZT) 22, but not at ZT10.	Ornithine	90-101	growth hormone	Mus musculus	35-37
25286138-8	2015	The effects of L-ornithine on plasma GH rhythms lasted for at least 2 days after cessation of the daily administration.	Ornithine	15-26	growth hormone	Mus musculus	37-39
25286138-11	2015	In conclusion, our data suggest that a daily administration of L-ornithine regulates the diurnal rhythms of GH, melatonin, and corticosterone in a manner dependent on administration time, which might be related to the diurnal rhythms of L-ornithine metabolism.	Ornithine	63-74	growth hormone	Mus musculus	108-110
26639850-1	2015	Brain protein synthesis and the plasma concentration of growth hormone (GH) are sensitive to dietary ornithine.	Ornithine	101-110	gonadotropin releasing hormone receptor	Rattus norvegicus	56-70
25434494-1	2015	Ornithine transcarbamylase deficiency (OTCD, OMIM 311250), the most common urea cycle disorder, results in impaired synthesis of citrulline from carbamoyl phosphate and ornithine.	Ornithine	169-178	ornithine transcarbamylase	Homo sapiens	0-26
25526897-3	2015	Intragastric injection of l-ornithine (2.5%) in urethane-anesthetized rats activated sympathetic nerve activity to white adipose tissue (WAT-SNA), and stimulated sympathetic nerve activity to brown adipose tissue (BAT-SNA).	Ornithine	26-37	snail family transcriptional repressor 1	Rattus norvegicus	141-144
25526897-3	2015	Intragastric injection of l-ornithine (2.5%) in urethane-anesthetized rats activated sympathetic nerve activity to white adipose tissue (WAT-SNA), and stimulated sympathetic nerve activity to brown adipose tissue (BAT-SNA).	Ornithine	26-37	snail family transcriptional repressor 1	Rattus norvegicus	218-221
25526897-4	2015	In addition, WAT-SNA responses to l-ornithine were abolished in rats with ablated abdominal vagal nerves.	Ornithine	34-45	snail family transcriptional repressor 1	Rattus norvegicus	17-20
25526897-6	2015	Proopiomelanocortin (POMC) levels in the hypothalamus and uncoupling protein 1 (UCP1) levels in brown adipose tissue were significantly increased in rats that ingested 2.5% l-ornithine for 9 weeks.	Ornithine	173-184	proopiomelanocortin	Rattus norvegicus	0-19
25526897-6	2015	Proopiomelanocortin (POMC) levels in the hypothalamus and uncoupling protein 1 (UCP1) levels in brown adipose tissue were significantly increased in rats that ingested 2.5% l-ornithine for 9 weeks.	Ornithine	173-184	proopiomelanocortin	Rattus norvegicus	21-25
25526897-6	2015	Proopiomelanocortin (POMC) levels in the hypothalamus and uncoupling protein 1 (UCP1) levels in brown adipose tissue were significantly increased in rats that ingested 2.5% l-ornithine for 9 weeks.	Ornithine	173-184	uncoupling protein 1	Rattus norvegicus	58-78
25526897-6	2015	Proopiomelanocortin (POMC) levels in the hypothalamus and uncoupling protein 1 (UCP1) levels in brown adipose tissue were significantly increased in rats that ingested 2.5% l-ornithine for 9 weeks.	Ornithine	173-184	uncoupling protein 1	Rattus norvegicus	80-84
25516968-5	2015	Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in Mga mutant cells, and the survival of mutant ICM cells as well as ESCs is rescued in culture by the addition of exogenous putrescine.	Ornithine	66-75	ornithine decarboxylase, structural 1	Mus musculus	14-18
25516968-5	2015	Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in Mga mutant cells, and the survival of mutant ICM cells as well as ESCs is rescued in culture by the addition of exogenous putrescine.	Ornithine	66-75	MAX gene associated	Mus musculus	138-141
26639850-1	2015	Brain protein synthesis and the plasma concentration of growth hormone (GH) are sensitive to dietary ornithine.	Ornithine	101-110	gonadotropin releasing hormone receptor	Rattus norvegicus	72-74
26639850-4	2015	The concentrations of plasma growth hormone (GH) and fractional rates of protein synthesis in the brains increased significantly with the 20% casein+0.7% arginine diet and still more with the 20% casein+0.7% ornithine diet compared with the 20% casein diet alone.	Ornithine	208-217	gonadotropin releasing hormone receptor	Rattus norvegicus	29-43
25400637-4	2014	In this perspective, I discuss the function of recepteur d"origine nantais (RON) receptor tyrosine kinase in regulating the M2-like state of macrophage activation Besides decreasing pro-inflammatory cytokine production in response to toll-like receptor-4 activation, macrophage-stimulating protein strongly suppresses nitric oxide synthase and at the same time upregulates arginase, which is the rate limiting enzyme in the ornithine biosynthesis pathway.	Ornithine	424-433	toll like receptor 4	Homo sapiens	234-254
25416954-4	2014	The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation.	Ornithine	109-118	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	138-165
25416954-4	2014	The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation.	Ornithine	109-118	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	167-171
25614305-11	2015	Persistently low plasmatic levels of lysine, arginine, and ornithine, associated with dietary protein and caloric restriction and systemic inflammation, could determine a defect in coupling GH to IGF-1 production explaining why GH replacement therapy is not able to significantly improve growth impairment.	Ornithine	59-68	insulin like growth factor 1	Homo sapiens	196-201
25205820-0	2014	Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Galpha(i2).	Ornithine	62-73	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	85-94
25205820-9	2014	In contrast, the two- to threefold increase in insulin secretion evoked by L-arginine or L-ornithine (in the presence of 16 mM glucose) was significantly reduced in islets lacking Galpha(i2).	Ornithine	89-100	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	180-189
25140796-1	2014	Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway.	Ornithine	63-72	ornithine decarboxylase 1	Homo sapiens	0-23
25061098-10	2014	Thus, the adverse effect of MAO-NOS3 to reduce NO generation and the transport of arginine and ornithine into conceptuses is central to an explanation for failure of normal development of MAO-NOS3, compared to control conceptuses.	Ornithine	95-104	nitric oxide synthase 3	Homo sapiens	32-36
25140796-1	2014	Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway.	Ornithine	63-72	ornithine decarboxylase 1	Homo sapiens	25-28
24627544-7	2014	Use of MAO-SLC7A1 knockdown in conceptuses decreased arginine transport (73%, P<0.01), the abundance of ornithine decarboxylase, and nitric oxide synthase (NOS3) proteins, arginine-related amino acids [citrulline (76%, P<0.05) and ornithine (40%, P<0.05)], and polyamines, which likely accounts for their retarded development.	Ornithine	107-116	solute carrier family 7 member 1	Homo sapiens	11-17
24911253-1	2014	Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle.	Ornithine	69-78	arginase 1	Homo sapiens	0-10
24649071-3	2014	L-ornithine is a key amino acid in the urea cycle and is converted to putrescine by ornithine decarboxylase (ODC).	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	84-107
24889392-8	2014	RESULTS: Serum cortisol levels and the cortisol/DHEA-S ratio were significantly decreased in the L-ornithine group in comparison with the placebo group.	Ornithine	97-108	sulfotransferase family 2A member 1	Homo sapiens	48-54
24652292-2	2014	In this work, a member of this family, SLC25A29, previously reported to be a mitochondrial carnitine/acylcarnitine- or ornithine-like carrier, has been thoroughly characterized biochemically.	Ornithine	119-128	solute carrier family 25 member 29	Homo sapiens	39-47
24652292-4	2014	Its transport properties and kinetic parameters demonstrate that SLC25A29 transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine.	Ornithine	162-171	solute carrier family 25 member 29	Homo sapiens	65-73
24721342-2	2014	ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline.	Ornithine	78-87	origin recognition complex subunit 1	Homo sapiens	0-4
24721342-2	2014	ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline.	Ornithine	78-87	solute carrier family 25 member 15	Homo sapiens	23-31
24721342-8	2014	Our study demonstrates that the A15V mutation dramatically interferes with the transport properties of ORC1 since it was shown to inhibit ornithine transport nearly completely.	Ornithine	138-147	origin recognition complex subunit 1	Homo sapiens	103-107
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Ornithine	138-147	ornithine decarboxylase 1	Homo sapiens	163-166
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Ornithine	138-147	ornithine decarboxylase antizyme 1	Homo sapiens	203-205
24221352-2	2014	This study aimed to investigate OAT activity in adult mouse tissues to assess the potential contribution to ornithine metabolism and to determine OAT control during postnatal development.	Ornithine	108-117	ornithine aminotransferase	Mus musculus	32-35
24649071-3	2014	L-ornithine is a key amino acid in the urea cycle and is converted to putrescine by ornithine decarboxylase (ODC).	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	109-112
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Ornithine	101-110	arginase 1	Homo sapiens	0-10
24107421-2	2013	Gene targeting of the catalytic subunit (Slc7a9) in mice leads to excessive excretion of cystine, lysine, arginine, and ornithine.	Ornithine	120-129	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	Mus musculus	41-47
24019517-1	2013	In most cells, cationic amino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L (y(+)LAT) amino acid transporters.	Ornithine	70-81	catalase	Homo sapiens	111-114
23747282-2	2013	The first assay is based on the reduction of Delta(1)-pyrroline-5-carboxylate (P5C), generated from ornithine by OAT, using human pyrroline 5-carboxylate reductase 1 (PYCR1), which results in the concomitant oxidation of NADH (nicotinamide adenine dinucleotide, reduced form) to NAD+ (nicotinamide adenine dinucleotide, oxidized form).	Ornithine	100-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	45-77
23747282-2	2013	The first assay is based on the reduction of Delta(1)-pyrroline-5-carboxylate (P5C), generated from ornithine by OAT, using human pyrroline 5-carboxylate reductase 1 (PYCR1), which results in the concomitant oxidation of NADH (nicotinamide adenine dinucleotide, reduced form) to NAD+ (nicotinamide adenine dinucleotide, oxidized form).	Ornithine	100-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	79-82
23747282-2	2013	The first assay is based on the reduction of Delta(1)-pyrroline-5-carboxylate (P5C), generated from ornithine by OAT, using human pyrroline 5-carboxylate reductase 1 (PYCR1), which results in the concomitant oxidation of NADH (nicotinamide adenine dinucleotide, reduced form) to NAD+ (nicotinamide adenine dinucleotide, oxidized form).	Ornithine	100-109	ornithine aminotransferase	Homo sapiens	113-116
23747282-2	2013	The first assay is based on the reduction of Delta(1)-pyrroline-5-carboxylate (P5C), generated from ornithine by OAT, using human pyrroline 5-carboxylate reductase 1 (PYCR1), which results in the concomitant oxidation of NADH (nicotinamide adenine dinucleotide, reduced form) to NAD+ (nicotinamide adenine dinucleotide, oxidized form).	Ornithine	100-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	130-165
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Ornithine	64-75	arginase 1	Homo sapiens	15-19
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Ornithine	64-75	arginase 2	Homo sapiens	24-28
23747282-5	2013	This assay is recommended for the determination of the substrate activity of small molecules against OAT; measuring the transformation of L-ornithine at high concentrations by this assay is complicated by the fact that it also acts as a substrate for the L-glutamate oxidase (GluOx) reporter enzyme.	Ornithine	138-149	ornithine aminotransferase	Homo sapiens	101-104
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Ornithine	101-110	arginase 1	Homo sapiens	12-16
23179835-9	2013	M2 macrophages constitutively produce the enzyme arginase I (argI), which sequesters L-arginine from iNOS and results in the production of ornithine and downstream polyamines and L-proline.	Ornithine	139-148	arginase, liver	Mus musculus	49-59
23691124-11	2013	In the insulin deficient mice, plasma citrulline and ornithine levels also increased and additionally these animals displayed elevated BCAA and AAA levels like insulin resistant and diabetic patients.	Ornithine	53-62	insulin	Homo sapiens	7-14
23269670-5	2013	We found that the increase in [Ca(2+)](i) stimulated by l-ornithine correlated with GLP-1 secretion and that l-ornithine stimulation increased exocytosis in a dose-dependent manner.	Ornithine	56-67	glucagon	Mus musculus	84-89
23269670-6	2013	Furthermore, depletion of endogenous GPRC6A by a specific small interfering RNA (siRNA) inhibited the l-ornithine-induced [Ca(2+)](i) increase and GLP-1 secretion.	Ornithine	102-113	G protein-coupled receptor, family C, group 6, member A	Mus musculus	37-43
23269670-6	2013	Furthermore, depletion of endogenous GPRC6A by a specific small interfering RNA (siRNA) inhibited the l-ornithine-induced [Ca(2+)](i) increase and GLP-1 secretion.	Ornithine	102-113	glucagon	Mus musculus	147-152
23470627-2	2013	The product of arginase activity, L-ornithine, can be metabolized into polyamines by ornithine decarboxylase.	Ornithine	34-45	ornithine decarboxylase, structural 1	Mus musculus	85-108
23269670-4	2013	Application of a GPRC6A receptor antagonist, a phospholipase C inhibitor, or an IP(3) receptor antagonist significantly suppressed the l-ornithine-induced [Ca(2+)](i) increase.	Ornithine	135-146	G protein-coupled receptor, family C, group 6, member A	Mus musculus	17-23
23269670-4	2013	Application of a GPRC6A receptor antagonist, a phospholipase C inhibitor, or an IP(3) receptor antagonist significantly suppressed the l-ornithine-induced [Ca(2+)](i) increase.	Ornithine	135-146	inositol 1,4,5-triphosphate receptor 3	Mus musculus	80-94
22870827-1	2013	The cellular uptake of L-arginine and other cationic amino acids (such as L-lysine and L-ornithine) is mainly mediated by cationic amino acid transporter (CAT) proteins.	Ornithine	87-98	catalase	Homo sapiens	155-158
23142579-3	2013	The hydrogel was synthesized by embedding the L-ornithine-degrading enzymes L-ornithine aminotransferase (OAT) and L-ornithine decarboxylase (ODC) into a polymer network.	Ornithine	46-57	ornithine decarboxylase 1	Homo sapiens	115-140
23142579-3	2013	The hydrogel was synthesized by embedding the L-ornithine-degrading enzymes L-ornithine aminotransferase (OAT) and L-ornithine decarboxylase (ODC) into a polymer network.	Ornithine	46-57	ornithine decarboxylase 1	Homo sapiens	142-145
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Ornithine	89-98	interleukin 4	Mus musculus	0-4
23424623-3	2013	It has been reported that arginase II (ARG2), one of two ARGs, is aberrantly expressed in prostate cancer cells, which convert arginine into ornithine, resulting in a lack of arginine that weakens tumor-infiltrating lymphocytes and renders them dysfunctional.	Ornithine	141-150	arginase 2	Homo sapiens	39-43
23917584-6	2013	Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology.	Ornithine	120-129	ornithine decarboxylase 1	Homo sapiens	169-192
24244174-8	2013	Antibodies together with helminth larvae reprogrammed macrophages to express wound-healing associated genes, including Arginase-1, and the Arginase-1 product L-ornithine directly impaired larval motility.	Ornithine	158-169	arginase, liver	Mus musculus	139-149
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Ornithine	89-98	arginase, liver	Mus musculus	48-58
21975054-1	2012	Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea.	Ornithine	65-74	arginase 1	Rattus norvegicus	0-10
21975054-1	2012	Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea.	Ornithine	65-74	arginase 2	Rattus norvegicus	15-25
22411759-1	2012	BACKGROUND: The hemolytic products cell-free oxyhemoglobin (FHb) and arginase-1 reduce nitric oxide (NO) bioavailability by scavenging NO and by degrading the NO precursor arginine to ornithine, respectively.	Ornithine	184-193	arginase 1	Homo sapiens	69-79
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Ornithine	84-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-43
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Ornithine	84-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-49
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Ornithine	89-98	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22459664-2	2012	METHODS: Two BN-derivatives of the general structure [M-chelator]-(spacer)-BN(2-14)-NH(2), where M: (99m)Tc or (185/187)Re, chelator: Gly-Gly-Cys-, spacer: -(arginine)(3)-, M-BN-A; spacer: -(ornithine)(3)-, M-BN-O; have been prepared and evaluated as tumor imaging agents.	Ornithine	191-200	gastrin releasing peptide	Homo sapiens	13-15
22361732-12	2012	L-Orn or L-Pro restored restitution in cells treated with BEC or Arg1 shRNA, whereas the polyamine putrescine had no benefit.	Ornithine	0-5	arginase, liver	Mus musculus	65-69
22937649-8	2012	The increase of arginine, ornithine, and methionine contents promoted the activities of polyamines synthesis enzymes, which led to the significant increase of polyamines contents and the significant decrease of DAO and PAO activities.	Ornithine	26-35	amine oxidase copper containing 1	Homo sapiens	211-214
22937649-8	2012	The increase of arginine, ornithine, and methionine contents promoted the activities of polyamines synthesis enzymes, which led to the significant increase of polyamines contents and the significant decrease of DAO and PAO activities.	Ornithine	26-35	polyamine oxidase	Homo sapiens	219-222
22387109-4	2012	There were significant differences in L-arginine, L-citrulline, L-ornithine, agmatine, putrescine, spermidine, spermine, and glutamate, but not GABA, in the CA1, CA2/3, and dentate gyrus sub-regions of the hippocampus and the prefrontal, entorhinal, perirhinal, and postrhinal cortices in 24 (aged) and 4 (young) months old rats in a region-specific manner.	Ornithine	64-75	carbonic anhydrase 1	Rattus norvegicus	157-160
22262851-3	2012	Here we have characterized mutations of the proposed substrate binding site in the human ornithine carriers ORC1 and ORC2 by carrying out transport assays with a set of different substrates.	Ornithine	89-98	origin recognition complex subunit 1	Homo sapiens	108-112
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Ornithine	289-298	argininosuccinate lyase	Homo sapiens	76-99
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Ornithine	289-298	argininosuccinate lyase	Homo sapiens	101-104
22416259-2	2012	This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, which is further converted into spermidine and spermine.	Ornithine	70-79	arginase 1	Homo sapiens	26-30
22416259-2	2012	This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, which is further converted into spermidine and spermine.	Ornithine	85-94	ornithine decarboxylase 1	Homo sapiens	120-123
22262851-3	2012	Here we have characterized mutations of the proposed substrate binding site in the human ornithine carriers ORC1 and ORC2 by carrying out transport assays with a set of different substrates.	Ornithine	89-98	origin recognition complex subunit 2	Homo sapiens	117-121
22264771-9	2012	Among the metabolites that contributed most to the CSF signature were arginine, lysine, ornithine, serine, threonine and pyroglutamic acid, all found to be reduced in patients carrying a D90A SOD1 mutation.	Ornithine	88-97	superoxide dismutase 1	Homo sapiens	192-196
22033378-6	2012	L-Ornithine is substrate of ornithine decarboxylase (ODC) - one of the key enzymes of polyamine biosynthesis and a validated target for therapeutic intervention - producing putrescine, which in turn is converted to spermidine by condensing with an aminopropyl group from decarboxylated S-adenosylmethionine.	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	28-51
22188168-1	2012	Arabidopsis possesses two arginase-encoding genes, ARGAH1 and ARGAH2, catalysing the catabolism of arginine into ornithine and urea.	Ornithine	113-122	arginase	Arabidopsis thaliana	51-57
22188168-1	2012	Arabidopsis possesses two arginase-encoding genes, ARGAH1 and ARGAH2, catalysing the catabolism of arginine into ornithine and urea.	Ornithine	113-122	Arginase/deacetylase superfamily protein	Arabidopsis thaliana	62-68
21899873-1	2012	Pyridoxal 5"-phosphate (PLP), in the active site of ornithine 4,5-aminomutase (OAM), forms a Schiff base with N(delta) of the d-ornithine side chain and facilitates interconversion of the amino acid to (2R, 4S) 2,4-diaminopentanoic acid via a radical-based mechanism.	Ornithine	52-61	pyridoxal phosphatase	Homo sapiens	24-27
21899873-1	2012	Pyridoxal 5"-phosphate (PLP), in the active site of ornithine 4,5-aminomutase (OAM), forms a Schiff base with N(delta) of the d-ornithine side chain and facilitates interconversion of the amino acid to (2R, 4S) 2,4-diaminopentanoic acid via a radical-based mechanism.	Ornithine	126-137	pyridoxal phosphatase	Homo sapiens	24-27
22033378-6	2012	L-Ornithine is substrate of ornithine decarboxylase (ODC) - one of the key enzymes of polyamine biosynthesis and a validated target for therapeutic intervention - producing putrescine, which in turn is converted to spermidine by condensing with an aminopropyl group from decarboxylated S-adenosylmethionine.	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	53-56
23132315-7	2012	The present results suggest that the treatment of young rats with ornithine is likely to increase the concentration of plasma GH and the rate of protein synthesis in the tissues, and that RNA activity is at least partly related to the fractional rate of tissue protein synthesis.	Ornithine	66-75	gonadotropin releasing hormone receptor	Rattus norvegicus	126-128
23132315-3	2012	The plasma concentration of growth hormone (GH) was the highest in rats fed 0.5 and 0.7% ornithine added to the 20% casein diet.	Ornithine	89-98	gonadotropin releasing hormone receptor	Rattus norvegicus	28-42
23327970-1	2012	The purpose of this study was to determine whether the regulation of brain protein synthesis is mediated through changes in the plasma concentration of growth hormone (GH) when dietary ornithine treatment is manipulated in the hypophysectomized or sham-operated aged rats.	Ornithine	185-194	gonadotropin releasing hormone receptor	Rattus norvegicus	152-166
23132315-3	2012	The plasma concentration of growth hormone (GH) was the highest in rats fed 0.5 and 0.7% ornithine added to the 20% casein diet.	Ornithine	89-98	gonadotropin releasing hormone receptor	Rattus norvegicus	44-46
23327970-1	2012	The purpose of this study was to determine whether the regulation of brain protein synthesis is mediated through changes in the plasma concentration of growth hormone (GH) when dietary ornithine treatment is manipulated in the hypophysectomized or sham-operated aged rats.	Ornithine	185-194	gonadotropin releasing hormone receptor	Rattus norvegicus	168-170
23327970-3	2012	The concentrations of plasma GH and fractional rates of protein synthesis in the brains increased significantly with the 20% casein+0.7% ornithine compared with the 20% casein diet alone in the sham-operated rats.	Ornithine	137-146	gonadotropin releasing hormone receptor	Rattus norvegicus	29-31
23327970-7	2012	The results suggest that the treatment with ornithine is likely to increase the concentration of GH and the rate of brain protein synthesis in the sham-operated rats only, not in the hypophysectomized rats, and that the ornithine-induced increase in the concentration of GH may be primarily responsible for changes in the brain protein synthesis.	Ornithine	44-53	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
23327970-7	2012	The results suggest that the treatment with ornithine is likely to increase the concentration of GH and the rate of brain protein synthesis in the sham-operated rats only, not in the hypophysectomized rats, and that the ornithine-induced increase in the concentration of GH may be primarily responsible for changes in the brain protein synthesis.	Ornithine	44-53	gonadotropin releasing hormone receptor	Rattus norvegicus	271-273
23327970-7	2012	The results suggest that the treatment with ornithine is likely to increase the concentration of GH and the rate of brain protein synthesis in the sham-operated rats only, not in the hypophysectomized rats, and that the ornithine-induced increase in the concentration of GH may be primarily responsible for changes in the brain protein synthesis.	Ornithine	220-229	gonadotropin releasing hormone receptor	Rattus norvegicus	271-273
22022700-2	2011	The present work deals with diamine oxidase immobilized on iron oxide nanoparticles for quantifying the amount of putrescine produced, by the decarboxylation of ornithine, which is converted into hydrogen peroxide by the enzyme diamine oxidase (DAO).	Ornithine	161-170	amine oxidase copper containing 1	Homo sapiens	28-43
23024808-3	2012	Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).	Ornithine	48-57	pyrroline-5-carboxylate reductase 1	Homo sapiens	106-109
23024808-3	2012	Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).	Ornithine	48-57	pyrroline-5-carboxylate reductase 1	Homo sapiens	81-104
21945700-1	2012	Arginase (EC 3.5.3.1; L-arginine amidinohydrolase) is a key enzyme of the urea cycle that catalyses the conversion of arginine to ornithine and urea, which is the final cytosolic reaction of urea formation in the mammalian liver.	Ornithine	130-139	arginase 2	Homo sapiens	22-49
23430880-1	2012	The Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome is a disorder of the urea cycle and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter, ORNT1 (SLC25A15).	Ornithine	9-18	solute carrier family 25 member 15	Homo sapiens	200-205
23430880-1	2012	The Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome is a disorder of the urea cycle and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter, ORNT1 (SLC25A15).	Ornithine	9-18	solute carrier family 25 member 15	Homo sapiens	207-215
22022700-2	2011	The present work deals with diamine oxidase immobilized on iron oxide nanoparticles for quantifying the amount of putrescine produced, by the decarboxylation of ornithine, which is converted into hydrogen peroxide by the enzyme diamine oxidase (DAO).	Ornithine	161-170	amine oxidase copper containing 1	Homo sapiens	228-243
22022700-2	2011	The present work deals with diamine oxidase immobilized on iron oxide nanoparticles for quantifying the amount of putrescine produced, by the decarboxylation of ornithine, which is converted into hydrogen peroxide by the enzyme diamine oxidase (DAO).	Ornithine	161-170	amine oxidase copper containing 1	Homo sapiens	245-248
21917546-3	2011	Stable isotope labeling experiments show that, after MeJA elicitation, Arg, Pro, and Glu are converted to Orn, which is acetylated by NATA1 to produce N(delta)-acetylornithine.	Ornithine	106-109	Acyl-CoA N-acyltransferases (NAT) superfamily protein	Arabidopsis thaliana	134-139
21736537-3	2011	The syndrome results from a deficiency of the mitochondrial enzyme OTC which catalyses the conversion of ornithine and carbamoyl phosphate to citrulline.	Ornithine	105-114	ornithine transcarbamylase	Homo sapiens	67-70
21807072-6	2011	Abeta(25-35) resulted in significantly decreased nitric oxide synthase (NOS) activity and endothelial NOS protein expression, but increased arginase activity, arginase II protein expression, and ornithine and putrescine levels, in hippocampal CA2/3.	Ornithine	195-204	amyloid beta precursor protein	Rattus norvegicus	0-5
21650455-8	2011	In summary, a biosynthetic route for the generation of delta-N-acetyl-delta-N-hydroxy-L-ornithine starting from L-ornithine has been established in vitro by tandem action of the FAD-dependent monooxygenase EtcB and the bifunctional malonyl-CoA decarboxylase/acetyltransferase Mcd.	Ornithine	86-97	malonyl-CoA decarboxylase	Homo sapiens	232-257
21512157-6	2011	Under conditions of glutamine depletion, supplementation of ornithine or polyamines restored the heat-induced expression of Hsp70 and Hsp25.	Ornithine	60-69	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	124-129
21512157-6	2011	Under conditions of glutamine depletion, supplementation of ornithine or polyamines restored the heat-induced expression of Hsp70 and Hsp25.	Ornithine	60-69	heat shock protein family B (small) member 1	Rattus norvegicus	134-139
21585399-3	2011	AAMs exert their activity in part via the enzyme arginase-1 (Arg1), which hydrolyses L-arginine into urea and ornithine, and can supply precursor substrate for proline and polyamine production.	Ornithine	110-119	arginase, liver	Mus musculus	61-65
21136528-1	2011	Arginase (EC 3.5.3.1) catalyzes the hydrolysis of arginine to ornithine and urea.	Ornithine	62-71	arginase	Bombyx mori	0-8
21232776-1	2011	The pyrrolidine ring of nicotine is derived from the diamine putrescine, which can be synthesized either directly from ornithine via the action of ODC, or from arginine via a three enzymatic step process, initiated by ADC.	Ornithine	119-128	ornithine decarboxylase	Nicotiana tabacum	147-150
20811048-1	2011	PURPOSE: The authors previously reported ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells as an in vitro model of gyrate atrophy of the choroid and retina (GA).	Ornithine	41-50	ornithine aminotransferase	Homo sapiens	67-99
20811048-6	2011	RESULTS: NO production in 5-FMO-treated hTERT-RPE cells was increased by ornithine, and the NO donors S-nitroso-N-acetyl-DL-penicillamine (SNAP) and S-nitrosoglutathione induced cytotoxicity.	Ornithine	73-82	telomerase reverse transcriptase	Homo sapiens	40-45
21310339-1	2011	Argininemia is caused by a deficiency of arginase 1, which catalyzes the final step in the urea cycle, i.e., the cytosolic hydrolysis of arginine to ornithine and urea.	Ornithine	149-158	arginase 1	Homo sapiens	41-51
20512387-2	2011	The PAs are synthesized by a metabolic process which involves arginase (ARG), which catalyzes the enzymatic hydrolysis of L-arginine (L-Arg) to L-ornithine and urea, and ornithine decarboxylase (ODC), which catalyzes the enzymatic decarboxylation of L-ornithine in putrescine.	Ornithine	250-261	ornithine decarboxylase 1	Homo sapiens	170-193
20831369-2	2011	Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines.	Ornithine	58-67	ornithine decarboxylase 1	Homo sapiens	0-23
20831369-2	2011	Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines.	Ornithine	58-67	ornithine decarboxylase 1	Homo sapiens	25-28
21265888-6	2011	Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), which is assumed to be required for the conversion of ornithine into citrulline in arginine biosynthesis.	Ornithine	177-186	carbamoyl phosphate synthetase B	Arabidopsis thaliana	34-38
21265888-6	2011	Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), which is assumed to be required for the conversion of ornithine into citrulline in arginine biosynthesis.	Ornithine	177-186	carbamoyl phosphate synthetase A	Arabidopsis thaliana	43-47
21265888-4	2011	Taken together, these results indicate that ven3 and ven6 mutants experience a blockage of the conversion of ornithine into citrulline in the arginine pathway.	Ornithine	109-118	carbamoyl phosphate synthetase B	Arabidopsis thaliana	44-48
21904558-9	2011	The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.	Ornithine	84-93	HNP1	Homo sapiens	19-24
21265888-4	2011	Taken together, these results indicate that ven3 and ven6 mutants experience a blockage of the conversion of ornithine into citrulline in the arginine pathway.	Ornithine	109-118	carbamoyl phosphate synthetase A	Arabidopsis thaliana	53-57
21056090-0	2011	L-ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks.	Ornithine	0-11	corticotropin releasing hormone	Homo sapiens	23-53
21904558-9	2011	The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.	Ornithine	84-93	HNP1	Homo sapiens	158-163
21318879-8	2011	AzI is highly homologous to ODC, but it lacks ornithine decarboxylating activity.	Ornithine	46-55	antizyme inhibitor 1	Homo sapiens	0-3
20531247-7	2010	RESULTS: Injection of l-ornithine paradoxically induced pancreatic spermidine catabolism, possibly via activation of SSAT, after (>6 hours) appearance of the first histological signs of acute pancreatitis.	Ornithine	22-33	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	117-121
20558222-8	2010	This process was inhibited by substrates of cationic amino acid transporter (CAT)s, such as L-arginine, L-lysine, and L-ornithine.	Ornithine	120-129	catalase	Rattus norvegicus	77-80
20653567-5	2010	However, the ability to utilize exogenous Arg precursors (ornithine and citrulline) for growth in Arg-deficient medium strongly correlated with expression of the corresponding enzymes, OTC and ASS.	Ornithine	58-67	argininosuccinate synthase 1	Homo sapiens	193-196
20688526-1	2010	The formation of c(1) ions during collision-induced fragmentation of peptides with asparagine, ornithine, or glutamine at the N-terminal position 2 has been studied.	Ornithine	95-104	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	17-21
20688526-8	2010	Additional evidence is obtained by investigation of peptides with ornithine in N-terminal position 2, which in general exhibit c(1) ion intensities intermediate between the asparagine- and glutamine-containing species.	Ornithine	66-75	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	127-131
20661013-3	2010	Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea.	Ornithine	103-112	arginase 1	Homo sapiens	0-10
20673832-1	2010	Ornithine delta-aminotransferase (OAT) of the malaria parasite Plasmodium falciparum catalyzes the reversible conversion of ornithine into glutamate-5-semialdehyde and glutamate and is-in contrast to its human counterpart-activated by thioredoxin (Trx) by a factor of 10.	Ornithine	124-133	thioredoxin	Homo sapiens	235-246
20673832-1	2010	Ornithine delta-aminotransferase (OAT) of the malaria parasite Plasmodium falciparum catalyzes the reversible conversion of ornithine into glutamate-5-semialdehyde and glutamate and is-in contrast to its human counterpart-activated by thioredoxin (Trx) by a factor of 10.	Ornithine	124-133	thioredoxin	Homo sapiens	248-251
20673832-10	2010	Plasmodium might require a tight Trx-mediated control of OAT activity for coordinating ornithine homeostasis, polyamine synthesis, proline synthesis, and mitotic cell division.	Ornithine	87-96	thioredoxin	Homo sapiens	33-36
20661013-3	2010	Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea.	Ornithine	103-112	arginase 1	Homo sapiens	12-17
20576117-1	2010	BACKGROUND: Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine, respectively.	Ornithine	154-163	nitric oxide synthase 1, neuronal	Mus musculus	81-102
20381578-1	2010	Ornithine-delta-aminotransferase (OAT, EC 2.6.1.13) catalyzes the transamination of L-ornithine to L-glutamate-gamma-semialdehyde.	Ornithine	84-95	ornithine aminotransferase	Homo sapiens	0-32
20381578-1	2010	Ornithine-delta-aminotransferase (OAT, EC 2.6.1.13) catalyzes the transamination of L-ornithine to L-glutamate-gamma-semialdehyde.	Ornithine	84-95	ornithine aminotransferase	Homo sapiens	34-37
20430034-7	2010	It is concluded that the activation of PKCalpha stimulates arginine entry in human endothelial cells and shifts the metabolism of the cationic amino acid from NO synthesis to arginase-dependent production of ornithine and urea.	Ornithine	208-217	protein kinase C alpha	Homo sapiens	39-47
20172963-3	2010	We investigated the biological role of the basic amino acid carrier Basic Amino Acid Carrier2 (BAC2) from Arabidopsis that is structurally and functionally similar to ARG11, a yeast ornithine and arginine carrier, and to Arabidopsis BAC1.	Ornithine	182-191	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	68-93
20300016-1	2010	This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes.	Ornithine	98-107	insulin	Homo sapiens	231-238
20300016-7	2010	Because there was no between-group difference in the remaining hormone levels, it appears that the GH/IGF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation.	Ornithine	222-225	insulin like growth factor 1	Homo sapiens	102-107
20300016-7	2010	Because there was no between-group difference in the remaining hormone levels, it appears that the GH/IGF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation.	Ornithine	222-225	insulin like growth factor binding protein 3	Homo sapiens	108-115
20300016-0	2010	Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.	Ornithine	13-22	insulin	Homo sapiens	68-75
20300016-1	2010	This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes.	Ornithine	98-107	insulin	Homo sapiens	202-209
20300016-1	2010	This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes.	Ornithine	98-107	insulin	Homo sapiens	231-238
20172963-3	2010	We investigated the biological role of the basic amino acid carrier Basic Amino Acid Carrier2 (BAC2) from Arabidopsis that is structurally and functionally similar to ARG11, a yeast ornithine and arginine carrier, and to Arabidopsis BAC1.	Ornithine	182-191	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	95-99
19283444-3	2010	The reported results demonstrate that the functionalization of L-ornithine side-chain with a neutral sulfamoyl group can generate an arginine bioisostere which can be used for the synthesis of prototypes of a new class of human thrombin inhibitors.	Ornithine	63-74	coagulation factor II, thrombin	Homo sapiens	228-236
20853600-1	2010	Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) is the key enzyme in urea synthesis, hydrolyzing L-arginine into L-ornithine and urea.	Ornithine	116-127	arginase 2	Homo sapiens	0-8
20459380-1	2010	Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates.	Ornithine	120-129	ornithine transcarbamylase	Homo sapiens	0-26
20459380-1	2010	Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates.	Ornithine	120-129	ornithine transcarbamylase	Homo sapiens	28-31
21099300-7	2010	Of these, adenylate kinase 3 (AK3) is a mitochondrial enzyme which acts on GTP, and ornithine aminotransferase (OAT) lies on the pathway converting glutamate to ornithine.	Ornithine	84-93	adenylate kinase 3	Mus musculus	10-28
21099300-7	2010	Of these, adenylate kinase 3 (AK3) is a mitochondrial enzyme which acts on GTP, and ornithine aminotransferase (OAT) lies on the pathway converting glutamate to ornithine.	Ornithine	84-93	adenylate kinase 3	Mus musculus	30-33
20853600-1	2010	Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) is the key enzyme in urea synthesis, hydrolyzing L-arginine into L-ornithine and urea.	Ornithine	116-127	arginase 2	Homo sapiens	10-37
19897717-0	2009	ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine.	Ornithine	122-131	HNP1	Homo sapiens	35-40
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Ornithine	145-154	ADP-ribosyltransferase 1	Homo sapiens	39-43
19635796-1	2009	Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine.	Ornithine	126-135	ornithine decarboxylase 1	Homo sapiens	0-23
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Ornithine	145-154	HNP1	Homo sapiens	74-79
19897717-8	2009	On incubation of di- or mono-ADP-ribosyl-HNP-1 at 37 degrees C, ADP-ribosylarginine was partially replaced by ornithine, whereas ornithine was not detected by amino acid analysis and mass spectrometry of unmodified HNP-1 incubated under the same conditions.	Ornithine	110-119	HNP1	Homo sapiens	41-46
19897717-8	2009	On incubation of di- or mono-ADP-ribosyl-HNP-1 at 37 degrees C, ADP-ribosylarginine was partially replaced by ornithine, whereas ornithine was not detected by amino acid analysis and mass spectrometry of unmodified HNP-1 incubated under the same conditions.	Ornithine	129-138	HNP1	Homo sapiens	41-46
19754428-6	2009	The location of the NAG site is identical to that of the weak bacterial CPS activator IMP (inosine monophosphate) in Escherichia coli CPS, indicating a common origin for these sites and excluding any relatedness to the binding site of the other bacterial CPS activator, ornithine.	Ornithine	270-279	N-acetyl-alpha-glucosaminidase	Homo sapiens	20-23
19836834-2	2009	Here we report that the calcimimetic Calindol and the calcilytic NPS2143 antagonize increases in inositol phosphate elicited by L-ornithine-induced activation of mouse GPRC6A after transient coexpression with Galpha(qG66D) in HEK293 cells.	Ornithine	128-139	G protein-coupled receptor, family C, group 6, member A	Mus musculus	168-174
19836834-6	2009	The mutations F666A(3.32), F670A(3.36), W797A(6.48) caused a loss of L-ornithine ability to activate GPRC6A mutants.	Ornithine	69-80	G protein-coupled receptor, family C, group 6, member A	Mus musculus	101-107
20095969-11	2009	AzI is highly homologous with ODC, but it lacks ornithine-decarboxylating activity.	Ornithine	48-57	antizyme inhibitor 1	Homo sapiens	0-3
19635796-1	2009	Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine.	Ornithine	126-135	ornithine decarboxylase 1	Homo sapiens	25-28
19409412-1	2009	In the present article the influence of salts and additives, such as trehalose, NaCl, ornithine, sodium phosphate and ammonium sulphate, on ornithine carbamoyltransferase (OCTase) is investigated in order to study the OCTase stabilization process as a function of solutes and to point out the fundamental role played by an enhancement of hydrophobic interactions.	Ornithine	86-95	ornithine transcarbamylase	Homo sapiens	140-170
19625684-6	2009	Ornithine aminotransferase, the regulated enzyme of arginine and ornithine catabolism, is restricted to the same zone 3 cells as glutamine synthetase, whereas the urea cycle is found in the remaining hepatocytes.	Ornithine	65-74	ornithine aminotransferase	Homo sapiens	0-26
19409412-1	2009	In the present article the influence of salts and additives, such as trehalose, NaCl, ornithine, sodium phosphate and ammonium sulphate, on ornithine carbamoyltransferase (OCTase) is investigated in order to study the OCTase stabilization process as a function of solutes and to point out the fundamental role played by an enhancement of hydrophobic interactions.	Ornithine	86-95	ornithine transcarbamylase	Homo sapiens	172-178
19554542-2	2009	We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing glutamine production (ammonia removal) through muscle glutamine synthetase and (2) phenylacetate conjugating with the ornithine-derived glutamine to form phenylacetylglutamine, which is excreted into the urine.	Ornithine	38-49	glutamate-ammonia ligase	Sus scrofa	210-230
19173225-1	2009	L-citrulline, L-ornithine, and agmatine are the metabolites of L-arginine by nitric oxide synthase (NOS), arginase, and arginine decarboxylase (ADC), respectively.	Ornithine	14-25	antizyme inhibitor 2	Rattus norvegicus	120-142
19173225-1	2009	L-citrulline, L-ornithine, and agmatine are the metabolites of L-arginine by nitric oxide synthase (NOS), arginase, and arginine decarboxylase (ADC), respectively.	Ornithine	14-25	antizyme inhibitor 2	Rattus norvegicus	144-147
19554542-2	2009	We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing glutamine production (ammonia removal) through muscle glutamine synthetase and (2) phenylacetate conjugating with the ornithine-derived glutamine to form phenylacetylglutamine, which is excreted into the urine.	Ornithine	40-49	glutamate-ammonia ligase	Sus scrofa	210-230
19287344-1	2009	The hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a disorder of the urea cycle (UCD) and ornithine degradation pathway caused by mutations in the mitochondrial ornithine transporter (ORNT1).	Ornithine	9-18	solute carrier family 25 member 15	Homo sapiens	206-211
19287344-4	2009	Here, we report that both the human and mouse SLC25A29, previously identified as mitochondrial carnitine/acyl-carnitine transporter-like, when overexpressed transiently also rescues the impaired ornithine transport in cultured HHH fibroblasts.	Ornithine	195-204	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	Mus musculus	46-54
19287344-6	2009	These results suggest a potential physiologic role for the SLC25A29 transporter in the oxidation of fatty acids, ornithine degradation pathway, and possibly the urea cycle.	Ornithine	113-122	solute carrier family 25 member 29	Homo sapiens	59-67
19345633-1	2009	AIMS: Ornithine delta-aminotransferase (OAT) deficiency causes gyrate atrophy (GA) of the retina, as a consequence of high plasma ornithine concentrations.	Ornithine	130-139	ornithine aminotransferase	Homo sapiens	6-38
19409905-1	2009	N-Acetyl-L-glutamate kinase (NAGK) catalyzes the first committed step in arginine biosynthesis in organisms that perform the cyclic pathway of ornithine synthesis.	Ornithine	143-152	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	29-33
19440938-4	2009	Cell ODC activities were assayed using 14CO2 generation from 14C-labeled L-ornithine.	Ornithine	73-84	ornithine decarboxylase, structural 1	Mus musculus	5-8
19440939-6	2009	Cell ODC activities were assayed using 14CO2 generation from 14C-labeled L-ornithine.	Ornithine	73-84	ornithine decarboxylase 1	Homo sapiens	5-8
19440939-8	2009	After cell lysis, ODC activity was determined using 14C-labeled L-ornithine.	Ornithine	64-75	ornithine decarboxylase 1	Homo sapiens	18-21
19440939-9	2009	ODC activity was estimated by the 14CO2 generated from 14C-labeled L-ornithine, as generated d.p.m.	Ornithine	67-78	ornithine decarboxylase 1	Homo sapiens	0-3
19105697-4	2009	OAT2 is a member of the N-terminal nucleophile (Ntn) hydrolase enzyme superfamily and catalyzes the reversible transfer of an acetyl group between the alpha-amino groups of ornithine and glutamate in a mechanism proposed to involve an acyl-enzyme complex.	Ornithine	173-182	solute carrier family 22 member 7	Homo sapiens	0-4
19318352-5	2009	Biochemical characterizations revealed that OTC Lys88 acetylation decreases the affinity for carbamoyl phosphate, one of the two OTC substrates, and the maximum velocity, whereas the K(m) for ornithine, the other OTC substrate, is not affected.	Ornithine	192-201	ornithine transcarbamylase	Homo sapiens	44-47
18368465-1	2009	Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC).	Ornithine	97-106	ornithine decarboxylase 1	Rattus norvegicus	124-147
18368465-1	2009	Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC).	Ornithine	97-106	ornithine decarboxylase 1	Rattus norvegicus	149-152
18680626-2	2009	OAT controls the interconversion of ornithine into glutamate semi-aldehyde, and is therefore involved in the metabolism of arginine and glutamine which play a major role in N homeostasis.	Ornithine	36-45	ornithine aminotransferase	Mus musculus	0-3
18680626-8	2009	OAT overexpression decreased plasma and liver ornithine concentrations but did not affect glutamine or arginine homeostasis.	Ornithine	46-55	ornithine aminotransferase	Mus musculus	0-3
18680626-9	2009	There was an inverse relationship between ornithine levels and OAT activity.	Ornithine	42-51	ornithine aminotransferase	Mus musculus	63-66
19138872-1	2009	Ornithine transcarbamylase (OTC) deficiency is an X-linked inborn error of metabolism characterized by impaired synthesis of citrulline from carbamylphosphate and ornithine.	Ornithine	163-172	ornithine transcarbamylase	Homo sapiens	0-26
19138872-1	2009	Ornithine transcarbamylase (OTC) deficiency is an X-linked inborn error of metabolism characterized by impaired synthesis of citrulline from carbamylphosphate and ornithine.	Ornithine	163-172	ornithine transcarbamylase	Homo sapiens	28-31
18827361-1	2008	Bacterial membrane constituents, such as Ornithine-containing lipid (OL) and the lipid A portion of lipopolysaccharide, trigger various immune responses through recognition by Toll-like receptor (TLR) 4.	Ornithine	41-50	toll like receptor 4	Homo sapiens	196-199
18978333-1	2008	BACKGROUND: Hyperornithinaemia-hyperammonaemia-homocitrullinuria (HHH) syndrome (OMIM 238970) is caused by impaired ornithine transport across the inner mitochondrial membrane due to mutations in SLC25A15.	Ornithine	116-125	solute carrier family 25 member 15	Homo sapiens	196-204
19636440-9	2009	Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.	Ornithine	122-131	NLR family pyrin domain containing 3	Homo sapiens	70-73
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Ornithine	269-282	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Ornithine	269-282	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Ornithine	269-282	pyrroline-5-carboxylate reductase 1	Homo sapiens	53-56
18401542-3	2008	The short form (P5CS.short) is highly expressed in the gut and is inhibited by ornithine.	Ornithine	79-88	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-20
18280134-3	2008	All-transretinoic acid (RA), an active metabolite of vitamin A, regulates the activity of several metabolic enzymes related to OAT, including ornithine decarboxylase and arginase, which may influence the function of OAT through effects on substrate (ornithine) availability.	Ornithine	142-151	ornithine aminotransferase	Homo sapiens	127-130
18759245-9	2008	Arginase competes with iNOS for arginine, catalyzing its hydrolysis to ornithine and urea.	Ornithine	71-80	nitric oxide synthase 2	Homo sapiens	23-27
18478038-8	2008	In an in vivo assay of flux through this metabolic pathway using dermal fibroblasts obtained from an affected individual, proline and ornithine biosynthetic activity of P5CS was not affected by the H784Y substitution.	Ornithine	134-143	aldehyde dehydrogenase 18 family member A1	Homo sapiens	169-173
18280134-3	2008	All-transretinoic acid (RA), an active metabolite of vitamin A, regulates the activity of several metabolic enzymes related to OAT, including ornithine decarboxylase and arginase, which may influence the function of OAT through effects on substrate (ornithine) availability.	Ornithine	142-151	ornithine aminotransferase	Homo sapiens	216-219
18280134-6	2008	Treatment with RA induced increases in OAT gene expression and enzymatic activity, which resulted in decreased intracellular concentrations of ornithine and polyamines (putrescine, spermidine and spermine) in a dose-dependent manner.	Ornithine	143-152	ornithine aminotransferase	Homo sapiens	39-42
18280134-9	2008	We conclude that exposure of Caco-2 cells to RA induces OAT expression for increasing ornithine catabolism.	Ornithine	86-95	ornithine aminotransferase	Homo sapiens	56-59
18221783-4	2008	In whole vessel segments, the GPRC6A activators, 300 microM l-ornithine and 100 microM Al(3+), induced endothelium-dependent myocyte hyperpolarizations sensitive to 10 microM TRAM-34, a blocker of intermediate conductance, Ca(2+)-sensitive K(+) channels (IK(Ca)).	Ornithine	60-71	G protein-coupled receptor, class C, group 6, member A	Rattus norvegicus	30-36
18806120-1	2008	The cellular metabolism of glutamine and proline are closely interrelated, because they can be interconverted with glutamate and ornithine via the mitochondrial pathway involving pyrroline-5-carboxylate (P5C).	Ornithine	129-138	pyrroline-5-carboxylate reductase 1	Homo sapiens	204-207
18712872-1	2008	Chlorofusin is a recently isolated, naturally occurring inhibitor of p53-MDM2 complex formation whose structure is composed of a densely functionalized azaphilone-derived chromophore linked through the terminal amine of ornithine to a nine residue cyclic peptide.	Ornithine	220-229	tumor protein p53	Homo sapiens	69-72
18712872-1	2008	Chlorofusin is a recently isolated, naturally occurring inhibitor of p53-MDM2 complex formation whose structure is composed of a densely functionalized azaphilone-derived chromophore linked through the terminal amine of ornithine to a nine residue cyclic peptide.	Ornithine	220-229	MDM2 proto-oncogene	Homo sapiens	73-77
18221783-7	2008	In the presence of 300 microM l-ornithine or 100 microM Al(3+), myocyte hyperpolarizations to calindol were potentiated whereas this potentiation and hyperpolarizations to l-ornithine were lost following incubation with an anti-GPRC6A antibody.	Ornithine	30-41	G protein-coupled receptor, class C, group 6, member A	Rattus norvegicus	228-234
18991196-3	2008	In contrast, corticotropin (ACTH) treatment was associated with increased alanine and phenylalanine, and decreased taurine compared to controls and untreated OMS, and increased glutamine, lysine, ornithine, and tyrosine compared to untreated OMS.	Ornithine	196-205	proopiomelanocortin	Homo sapiens	28-32
18816238-5	2008	Calcineurin inhibitor toxicity was associated with low levels of docosahexaenoic acid, ornithine, and the omega-3 index, and high total omega-6 and omega-3/omega-6 ratios.	Ornithine	87-96	calcineurin binding protein 1	Homo sapiens	0-21
18477767-1	2008	The proteinase-activated receptor-2 (PAR2)-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH2 (2fLI), was derivatized via its free ornithine amino group to yield [3H]propionyl-2fLI and Alexa Fluor 594-2fLI that were used as receptor probes for ligand binding assays and receptor visualization both for cultured cells in vitro and for colonic epithelial cells in vivo.	Ornithine	165-174	F2R like trypsin receptor 1	Rattus norvegicus	4-35
18477767-1	2008	The proteinase-activated receptor-2 (PAR2)-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH2 (2fLI), was derivatized via its free ornithine amino group to yield [3H]propionyl-2fLI and Alexa Fluor 594-2fLI that were used as receptor probes for ligand binding assays and receptor visualization both for cultured cells in vitro and for colonic epithelial cells in vivo.	Ornithine	165-174	F2R like trypsin receptor 1	Rattus norvegicus	37-41
18477767-5	2008	We conclude that ornithine-derivatized 2fLI peptides are conveniently synthesized PAR2 probes that will be of value for future studies of receptor binding and visualization.	Ornithine	17-26	F2R like trypsin receptor 1	Rattus norvegicus	82-86
18594222-10	2008	Oxidative stress in the pancreas was evident from 6 hrs; HSP72 synthesis was increased from 4 hrs after L-ornithine administration.	Ornithine	104-115	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	57-62
18991196-5	2008	The ACTH dose-association was most apparent for alanine and phosphoethanolamine, but lysine and ornithine were also higher in the high-dose ACTH group.	Ornithine	96-105	proopiomelanocortin	Homo sapiens	140-144
18419821-3	2008	RESULTS: We show here that ornithine-delta-aminotransferase (deltaOAT, At5g46180), the enzyme converting Orn to pyrroline-5-carboxylate (P5C), is localised in mitochondria and is essential for Arg catabolism.	Ornithine	105-108	ornithine-delta-aminotransferase	Arabidopsis thaliana	27-59
23105736-1	2008	Currently available method(s) for assaying pyrroline-5-carboxylate (P5C), an important intermediate metabolite of ornithine, proline and glutamate metabolic pathways, are cumbersome or not sensitive enough for microanalysis.	Ornithine	114-123	pyrroline-5-carboxylate reductase 1	Homo sapiens	68-71
18172665-2	2008	Moreover, we tested the hypothesis that L -arginine and L -ornithine influence the expression and synthesis of hCAT1 and hCAT2 in cell culture experiments by means of real-time-PCR and Western blot.	Ornithine	56-68	solute carrier family 7 member 1	Homo sapiens	111-116
18330478-1	2008	Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine, has become a promising target for cancer research.	Ornithine	102-111	ornithine decarboxylase 1	Homo sapiens	0-23
18330478-1	2008	Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine, has become a promising target for cancer research.	Ornithine	102-111	ornithine decarboxylase 1	Homo sapiens	25-28
18172665-2	2008	Moreover, we tested the hypothesis that L -arginine and L -ornithine influence the expression and synthesis of hCAT1 and hCAT2 in cell culture experiments by means of real-time-PCR and Western blot.	Ornithine	56-68	solute carrier family 7 member 2	Homo sapiens	121-126
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Ornithine	133-142	glycine amidinotransferase	Rattus norvegicus	36-73
17768678-0	2008	Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition.	Ornithine	39-48	monoamine oxidase A	Rattus norvegicus	76-93
18182242-5	2008	We now report on new BK B1R antagonist analogs of B9958 with N-terminal basic residues in the d-configuration, or Lys-, Orn- derivatives (NiK, epsilon-nicotinoyllysine; PzO, 3-pyrazinoylornithine) and/or having hindered unusual amino acids at position 5 (Igl, alpha-(2-indanyl)glycine).	Ornithine	120-123	bradykinin receptor B1	Homo sapiens	21-27
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Ornithine	124-133	solute carrier family 7 member 1	Homo sapiens	47-80
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Ornithine	124-133	solute carrier family 7 member 1	Homo sapiens	82-86
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Ornithine	133-142	glycine amidinotransferase	Rattus norvegicus	75-79
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Ornithine	133-142	guanidinoacetate N-methyltransferase	Rattus norvegicus	171-205
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Ornithine	133-142	guanidinoacetate N-methyltransferase	Rattus norvegicus	207-211
17686999-1	2007	The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been established, but the exact source of ornithine has always been unclear.	Ornithine	12-21	ornithine decarboxylase, structural 1	Mus musculus	37-40
17934762-2	2007	C/EBP alpha activates albumin transcription and coordinates the expression of multiple ornithine cycle enzymes involved in urea production.	Ornithine	87-96	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	0-11
17934762-5	2007	mRNA levels for the ornithine cycle enzymes, namely arginase, carbamylphosphate synthetase 1, and ornithine transcarbamylase, also increase.	Ornithine	20-29	ornithine transcarbamylase	Mus musculus	98-124
17604199-2	2007	OAT transaminates ornithine to pyrroline 5-carboxylate, which is further catalyzed to proline by pyrroline 5-carboxylate reductase.	Ornithine	18-27	ornithine aminotransferase	Homo sapiens	0-3
17612583-1	2007	In species of the genus Nicotiana, as in most plants, the important polyamine precursor putrescine can be derived from the amino acids ornithine and/or arginine via the activity of ornithine decarboxylase (ODC) and/or arginine decarboxylase (ADC), respectively.	Ornithine	135-144	ornithine decarboxylase	Nicotiana tabacum	181-204
17612583-1	2007	In species of the genus Nicotiana, as in most plants, the important polyamine precursor putrescine can be derived from the amino acids ornithine and/or arginine via the activity of ornithine decarboxylase (ODC) and/or arginine decarboxylase (ADC), respectively.	Ornithine	135-144	ornithine decarboxylase	Nicotiana tabacum	206-209
17575112-4	2007	Structural analysis of the crystal structure of human ODC disclosed an additional hydrophobic pocket surrounding the epsilon-amino group of its substrate ornithine.	Ornithine	154-163	ornithine decarboxylase 1	Homo sapiens	54-57
17442735-4	2007	We hypothesized that MKP-1, by attenuating iNOS expression, acts as a switch changing L-arg metabolism from NO production to L-orn production after endotoxin administration.	Ornithine	125-130	dual specificity phosphatase 1	Mus musculus	21-26
17442735-4	2007	We hypothesized that MKP-1, by attenuating iNOS expression, acts as a switch changing L-arg metabolism from NO production to L-orn production after endotoxin administration.	Ornithine	125-130	nitric oxide synthase 2, inducible	Mus musculus	43-47
17494634-1	2007	We previously showed that ornithine was mainly transported via cationic amino acid transporter (CAT)-1 in human retinal pigment epithelial (RPE) cell line, human telomerase RT (hTERT)-RPE, and that CAT-1 was involved in ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient cell produced by a OAT specific inhibitor, 5-fluoromethylornithine (5-FMO).	Ornithine	26-35	solute carrier family 7 member 1	Homo sapiens	96-102
17494634-1	2007	We previously showed that ornithine was mainly transported via cationic amino acid transporter (CAT)-1 in human retinal pigment epithelial (RPE) cell line, human telomerase RT (hTERT)-RPE, and that CAT-1 was involved in ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient cell produced by a OAT specific inhibitor, 5-fluoromethylornithine (5-FMO).	Ornithine	26-35	solute carrier family 7 member 1	Homo sapiens	198-203
17494634-1	2007	We previously showed that ornithine was mainly transported via cationic amino acid transporter (CAT)-1 in human retinal pigment epithelial (RPE) cell line, human telomerase RT (hTERT)-RPE, and that CAT-1 was involved in ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient cell produced by a OAT specific inhibitor, 5-fluoromethylornithine (5-FMO).	Ornithine	26-35	ornithine aminotransferase	Homo sapiens	246-278
17494634-1	2007	We previously showed that ornithine was mainly transported via cationic amino acid transporter (CAT)-1 in human retinal pigment epithelial (RPE) cell line, human telomerase RT (hTERT)-RPE, and that CAT-1 was involved in ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient cell produced by a OAT specific inhibitor, 5-fluoromethylornithine (5-FMO).	Ornithine	220-229	solute carrier family 7 member 1	Homo sapiens	96-102
17494634-4	2007	ODC mRNA expression was also increased by ornithine and polyamines, and gene silencing of ODC by siRNA decreased ornithine transport activity and its cytotoxicity.	Ornithine	42-51	ornithine decarboxylase 1	Homo sapiens	0-3
17494634-4	2007	ODC mRNA expression was also increased by ornithine and polyamines, and gene silencing of ODC by siRNA decreased ornithine transport activity and its cytotoxicity.	Ornithine	113-122	ornithine decarboxylase 1	Homo sapiens	90-93
17494634-5	2007	In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC.	Ornithine	80-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
17494634-5	2007	In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC.	Ornithine	80-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
17494634-5	2007	In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC.	Ornithine	80-89	solute carrier family 7 member 1	Homo sapiens	170-175
17494634-5	2007	In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC.	Ornithine	80-89	ornithine decarboxylase 1	Homo sapiens	180-183
17494634-7	2007	These results suggest that spermine plays an important role in stimulation of mRNA expression of CAT-1, which is a crucial role in ornithine cytotoxicity in OAT-deficient hTERT-RPE cells.	Ornithine	131-140	solute carrier family 7 member 1	Homo sapiens	97-102
17197568-8	2007	Further, CAT-1 silencing by siRNA reduced ornithine cytotoxicity in OAT-deficient RPE cells.	Ornithine	42-51	solute carrier family 7 member 1	Homo sapiens	9-14
17512708-2	2007	Argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) are two ornithine cycle enzymes catalysing the last two steps in the arginine biosynthetic pathway.	Ornithine	77-86	argininosuccinate synthase 1	Homo sapiens	30-33
17512708-13	2007	Both ass and asl genes were up-regulated within 3h after harvest showing that the induction mechanism is very sensitive to the harvest event and emphasizes the importance of the arginine biosynthetic pathway/ornithine cycle in post-harvest physiology.	Ornithine	208-217	argininosuccinate synthase 1	Homo sapiens	5-8
17255300-7	2007	The increased arginase activity was limited to the CD11b(+)CD14(-) myeloid cells and resulted in significantly decreased serum levels of arginine and increased ornithine in patients.	Ornithine	160-169	integrin subunit alpha M	Homo sapiens	51-56
17140418-1	2007	Carbamoylphosphate synthetase-I is the flux-determining enzyme of the ornithine cycle, and neutralizes toxic ammonia by converting it to urea.	Ornithine	70-79	carbamoyl-phosphate synthase 1	Homo sapiens	0-31
17197568-1	2007	PURPOSE: A prior report showed ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells in an in vitro model of gyrate atrophy of the choroid and retina.	Ornithine	31-40	ornithine aminotransferase	Homo sapiens	57-89
17274762-6	2007	StIPMK also restores the amino acid profiles of mutant yeast to wild-type, and does so with ornithine or arginine as the sole nitrogen sources.	Ornithine	92-101	inositol polyphosphate multikinase	Solanum tuberosum	0-6
17119118-2	2007	The decreased production of nitric oxide (NO) by NOS and the production of ornithine by ARG1 affect immune responses and tissue regeneration at sites of infection, respectively.	Ornithine	75-84	arginase 1	Homo sapiens	88-92
17245368-8	2007	KEY RESULTS: Using our novel assay, we demonstrate that the basic L-alpha-amino acids ornithine, lysine, and arginine are the most potent agonists at wild-type mouse GPRC6A.	Ornithine	86-95	G protein-coupled receptor, family C, group 6, member A	Mus musculus	166-172
17197568-4	2007	Carrier-mediated ornithine transport via the L-type amino acid transporter (LAT)1, LAT2, cationic amino acid transporter (CAT)-1, and y(+)LAT2 systems was evaluated by short interfering (si)RNA-mediated gene silencing.	Ornithine	17-26	solute carrier family 7 member 5	Homo sapiens	76-81
17197568-9	2007	CONCLUSIONS: The results suggest that ornithine transport via CAT-1 may play a crucial role in ornithine cytotoxicity in hTERT-RPE cells.	Ornithine	38-47	solute carrier family 7 member 1	Homo sapiens	62-67
17197568-4	2007	Carrier-mediated ornithine transport via the L-type amino acid transporter (LAT)1, LAT2, cationic amino acid transporter (CAT)-1, and y(+)LAT2 systems was evaluated by short interfering (si)RNA-mediated gene silencing.	Ornithine	17-26	linker for activation of T cells family member 2	Homo sapiens	83-87
17197568-9	2007	CONCLUSIONS: The results suggest that ornithine transport via CAT-1 may play a crucial role in ornithine cytotoxicity in hTERT-RPE cells.	Ornithine	38-47	telomerase reverse transcriptase	Homo sapiens	121-126
17197568-4	2007	Carrier-mediated ornithine transport via the L-type amino acid transporter (LAT)1, LAT2, cationic amino acid transporter (CAT)-1, and y(+)LAT2 systems was evaluated by short interfering (si)RNA-mediated gene silencing.	Ornithine	17-26	solute carrier family 7 member 1	Homo sapiens	122-128
17197568-9	2007	CONCLUSIONS: The results suggest that ornithine transport via CAT-1 may play a crucial role in ornithine cytotoxicity in hTERT-RPE cells.	Ornithine	95-104	solute carrier family 7 member 1	Homo sapiens	62-67
17197568-4	2007	Carrier-mediated ornithine transport via the L-type amino acid transporter (LAT)1, LAT2, cationic amino acid transporter (CAT)-1, and y(+)LAT2 systems was evaluated by short interfering (si)RNA-mediated gene silencing.	Ornithine	17-26	solute carrier family 7 member 6	Homo sapiens	134-142
17197568-9	2007	CONCLUSIONS: The results suggest that ornithine transport via CAT-1 may play a crucial role in ornithine cytotoxicity in hTERT-RPE cells.	Ornithine	95-104	telomerase reverse transcriptase	Homo sapiens	121-126
17197568-5	2007	The cytoprotective effect of CAT-1-specific siRNA on ornithine cytotoxicity was measured using quantitative analysis of cellular adenosine triphosphate (ATP) at 24 hours after treatment with ornithine in OAT-deficient RPE cells.	Ornithine	53-62	solute carrier family 7 member 1	Homo sapiens	29-34
17197568-5	2007	The cytoprotective effect of CAT-1-specific siRNA on ornithine cytotoxicity was measured using quantitative analysis of cellular adenosine triphosphate (ATP) at 24 hours after treatment with ornithine in OAT-deficient RPE cells.	Ornithine	191-200	solute carrier family 7 member 1	Homo sapiens	29-34
17197568-10	2007	Reduction of the ornithine transport via CAT-1 may be a new target for treatment of gyrate atrophy.	Ornithine	17-26	solute carrier family 7 member 1	Homo sapiens	41-46
16939563-4	2006	Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation.	Ornithine	45-54	arginase 1	Homo sapiens	58-68
16916800-0	2006	Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.	Ornithine	6-15	ornithine decarboxylase antizyme 1	Mus musculus	51-59
16730327-9	2006	Early expression of BAC1 and BAC2 is consistent with the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine.	Ornithine	152-161	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	20-24
16730327-9	2006	Early expression of BAC1 and BAC2 is consistent with the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine.	Ornithine	152-161	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	29-33
16730327-10	2006	Increase of BAC2 transcript levels later in seedling development is consistent with roles in NO, polyamine or proline metabolism--processes involving arginine, citrulline and/or ornithine.	Ornithine	178-187	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	12-16
16946537-0	2006	Bitterness suppression of BCAA solutions by L-ornithine.	Ornithine	44-55	AT-rich interaction domain 4B	Homo sapiens	26-30
16906410-1	2006	Gyrate atrophy (GA) is a rare degenerative, hereditary disease characterized by markedly high serum ornithine levels resulting from the deficiency of ornithine-delta-amino transferase (OAT), a mitochondrial matrix enzyme.	Ornithine	100-109	ornithine aminotransferase	Homo sapiens	0-19
16906410-1	2006	Gyrate atrophy (GA) is a rare degenerative, hereditary disease characterized by markedly high serum ornithine levels resulting from the deficiency of ornithine-delta-amino transferase (OAT), a mitochondrial matrix enzyme.	Ornithine	100-109	ornithine aminotransferase	Homo sapiens	150-183
16432806-2	2006	By internal acylation of Lys, Orn, L-1,4-diaminobutyric acid (Dab), L-1,3-diaminopropionic acid (Dap) at position 4 with the C-terminal Gly of the peptide tail, we prepared cyclo-(4-9)-[Lys(4), Gly(9)]-PA (pA(2) = 8.77 +/- 0.27), 1, and cyclo-(4-9)-[Orn(4), Gly(9)]-PA (pA(2) = 8.81 +/- 0.25), 3, which are equipotent with PA (pA(2) = 8.68 +/- 0.18) in the rat uterotonic assay and cyclo-(4-9)-[Dab(4), Gly(9)]-PA, 4, cyclo-(4-9)-[Dap(4), Gly(9)]-PA, 5, and cyclo-(4-9)-[Pmp(1), Lys(4), Gly(9)]-PA, 2, which were weaker OTAs.	Ornithine	30-33	death-associated protein	Rattus norvegicus	97-100
16703566-1	2006	In murine macrophages, as a result of arginine catabolism during activation, citruline is produced under the effect of IFN-gamma and LPS, and ornithine and polyamines by IL-4 and IL-10.	Ornithine	142-151	interleukin 4	Mus musculus	170-174
16703566-9	2006	M-CSF-dependent proliferation was not affected in the macrophages of SLC7A2 knockout mice; however, these cells showed a drastic reduction in the production of citruline or ornithine and polyamines during activation.	Ornithine	173-182	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
16432806-2	2006	By internal acylation of Lys, Orn, L-1,4-diaminobutyric acid (Dab), L-1,3-diaminopropionic acid (Dap) at position 4 with the C-terminal Gly of the peptide tail, we prepared cyclo-(4-9)-[Lys(4), Gly(9)]-PA (pA(2) = 8.77 +/- 0.27), 1, and cyclo-(4-9)-[Orn(4), Gly(9)]-PA (pA(2) = 8.81 +/- 0.25), 3, which are equipotent with PA (pA(2) = 8.68 +/- 0.18) in the rat uterotonic assay and cyclo-(4-9)-[Dab(4), Gly(9)]-PA, 4, cyclo-(4-9)-[Dap(4), Gly(9)]-PA, 5, and cyclo-(4-9)-[Pmp(1), Lys(4), Gly(9)]-PA, 2, which were weaker OTAs.	Ornithine	30-33	death-associated protein	Rattus norvegicus	431-434
16410053-11	2006	These data stress the hypothesis of a metabolon-like organization of the urea cycle together with NOS-2 in hepatocytes as excess L-ornithine will be metabolized to l-arginine and thereby increases NO production.	Ornithine	129-140	nitric oxide synthase 2	Rattus norvegicus	98-103
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Ornithine	144-155	solute carrier family 7 member 1	Homo sapiens	63-96
16371438-10	2006	Furthermore, GM-CSF induced an increase in arginase activity and in the conversion of L-arginine to ornithine, citrulline, glutamate, proline, and polyamines.	Ornithine	100-109	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	13-19
16491103-3	2006	Agonists for GPRC6A are basic amino acids, particularly the analogues and derivatives of L-arginine and L-ornithine.	Ornithine	104-115	G protein-coupled receptor class C group 6 member A	Homo sapiens	13-19
16354653-3	2006	Previously, we found that in Selenomonas ruminantium, a strictly anaerobic and Gram-negative bacterium, a drastic degradation of lysine decarboxylase (LDC; EC 4.1.1.18), which has decarboxylase activities toward both L-lysine and L-ornithine with similar K(m) values, occurs upon entry into the stationary phase of cell growth by protease together with a protein of 22 kDa (P22).	Ornithine	230-241	dynein cytoplasmic 1 heavy chain 1	Mus musculus	374-377
16513374-5	2006	Proliferation of breast cancer cells was assessed from the activity of ornithine decarboxylase (ODC) using [(14)C] labeled ornithine.	Ornithine	71-80	ornithine decarboxylase 1	Homo sapiens	96-99
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Ornithine	144-155	solute carrier family 7 member 1	Homo sapiens	98-102
15811879-1	2005	Arginase 1, an enzyme induced by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible for the hydrolysis of L-arginine into ornithine, the building block for the production of polyamines.	Ornithine	158-167	arginase 1	Homo sapiens	0-10
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Ornithine	333-344	integrin subunit alpha M	Homo sapiens	24-29
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Ornithine	333-344	arginase 1	Homo sapiens	58-68
16078310-6	2006	The calibration curve was linear in the range 10-280 microg mL-1 for L-aspartic acid and 20-280 microg mL-1 for L-ornithine (for both amino acids, r=0.999).	Ornithine	112-123	L1 cell adhesion molecule	Mus musculus	103-107
16321608-3	2005	NEM, MTSEA and PLP inhibited the ornithine/citrulline carrier with a completely competitive type of mechanism.	Ornithine	33-42	proteolipid protein 1	Homo sapiens	15-18
16321608-6	2005	On the basis of the interferences between SH reagents and PLP in the transport inhibition, it has been deduced that the distance between the SH and the NH(2) residues of the active site should be comparable to the distance between the gamma-NH(2) and COOH residues of the ornithine molecule.	Ornithine	272-281	proteolipid protein 1	Homo sapiens	58-61
16155089-11	2006	These findings suggest that the use of iNOS gene therapy for pulmonary hypertensive disorders may not only be beneficial through NO-mediated pulmonary vasodilation but also may decrease vascular remodeling by limiting L-Orn production by native arginase.	Ornithine	218-223	nitric oxide synthase 2	Bos taurus	39-43
15576824-9	2005	Proline oxidase and OAT, but not arginase, were present in allantoic and amniotic fluids for the production of ornithine (the immediate substrate for polyamine synthesis).	Ornithine	111-120	ornithine aminotransferase, mitochondrial	Sus scrofa	20-23
15781468-7	2005	We propose that the induction of glutamine synthetase genes early in development and the subsequent formation of the active protein are preparatory for the increased capacity of the embryo to convert the toxic nitrogen end product, ammonia, into glutamine, which may then be utilized in the ornithine-urea cycle or other pathways.	Ornithine	291-300	glutamine synthetase	Oncorhynchus mykiss	33-53
15753084-12	2005	The results substantiate the hypothesis that intramitochondrial arginase, presumably the arginase-II isozyme, may play an important role in the regulation of hepatic ureagenesis by furnishing ornithine for net synthesis of N-acetylglutamate, citrulline, and aspartate.	Ornithine	192-201	arginase 2	Rattus norvegicus	89-100
17173623-1	2005	Ornithine decarboxylase (ODC) is a cytosolic enzyme that catalyses the direct decarboxylation of l-ornithine to putrescine, one of the rate-limiting steps of polyamine biosynthesis in plants.	Ornithine	97-108	ornithine decarboxylase	Nicotiana tabacum	0-23
17173623-1	2005	Ornithine decarboxylase (ODC) is a cytosolic enzyme that catalyses the direct decarboxylation of l-ornithine to putrescine, one of the rate-limiting steps of polyamine biosynthesis in plants.	Ornithine	97-108	ornithine decarboxylase	Nicotiana tabacum	25-28
15901937-7	2005	Ornithine decarboxylase (ODC), which catalyzes the conversion of ornithine to putrescine, fulfilled these prerequisites.	Ornithine	65-74	ornithine decarboxylase 1	Homo sapiens	0-23
15539552-1	2005	The enzymes ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) share L-ornithine as a common substrate and arginase II produces this amino acid.	Ornithine	85-96	ornithine aminotransferase	Mus musculus	12-38
15539552-1	2005	The enzymes ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) share L-ornithine as a common substrate and arginase II produces this amino acid.	Ornithine	85-96	ornithine decarboxylase, structural 1	Mus musculus	49-72
15539552-1	2005	The enzymes ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) share L-ornithine as a common substrate and arginase II produces this amino acid.	Ornithine	85-96	ornithine decarboxylase, structural 1	Mus musculus	74-77
15616821-10	2005	Finally, in the PST of females, L-arginine-derived ornithine may be a precursor for the renal production of L -glutamate and L-glutamine because high levels of AII, ornithine aminotransferase and glutamine synthetase are expressed in this nephron segment.	Ornithine	51-60	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	196-216
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	179-188	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	179-188	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15517380-8	2005	Furthermore, we show the results of ornithine loading tests and indirect enzyme studies corroborating the biological significance of the defect in P5CS in vivo.	Ornithine	36-45	aldehyde dehydrogenase 18 family member A1	Homo sapiens	147-151
16168128-2	2005	Ornithine decarboxylase converts ornithine to putrescine and is the rate-limiting step in polyamine synthesis.alpha-Difluoromethylornithine (DFMO) irreversibly inhibits ornithine decarboxylase and MDA-MB-435 human breast cancer metastasis to the lung without blocking orthotopic tumor growth.	Ornithine	33-42	ornithine decarboxylase 1	Homo sapiens	0-23
16168128-2	2005	Ornithine decarboxylase converts ornithine to putrescine and is the rate-limiting step in polyamine synthesis.alpha-Difluoromethylornithine (DFMO) irreversibly inhibits ornithine decarboxylase and MDA-MB-435 human breast cancer metastasis to the lung without blocking orthotopic tumor growth.	Ornithine	33-42	ornithine decarboxylase 1	Homo sapiens	169-192
15901937-7	2005	Ornithine decarboxylase (ODC), which catalyzes the conversion of ornithine to putrescine, fulfilled these prerequisites.	Ornithine	65-74	ornithine decarboxylase 1	Homo sapiens	25-28
15538644-3	2004	Concerning PMN immune function markers ornithine increased H2O2-generation and MPO activity while O2- -formation was decreased.	Ornithine	39-48	myeloperoxidase	Homo sapiens	79-82
15491978-2	2004	The human cationic amino acid transporter hCAT-1 is almost ubiquitously expressed and probably the most important entity for supplying cells with extracellular arginine, lysine, and ornithine.	Ornithine	182-191	solute carrier family 7 member 1	Homo sapiens	42-48
15535970-2	2004	Delta1-pyrroline-5-carboxylate is formed in liver from proline by proline oxidase (EC number not assigned) or from ornithine via ornithine aminotransferase.	Ornithine	115-124	ornithine aminotransferase	Rattus norvegicus	129-155
15190062-2	2004	The virus encodes a homolog of eukaryotic ornithine decarboxylase (ODC) that was previously demonstrated to be capable of decarboxylating l-ornithine.	Ornithine	138-149	ornithine decarboxylase 1	Homo sapiens	42-65
15494015-7	2004	It is probable that, in the face of chronically increased PtdIns(3,4,5)P(3) levels in their myeloid progenitors, SHIP1(-/-) mice display a skewed development away from M1 (killer) macrophages (which have high inducible nitric oxide synthase levels and produce NO to kill microorganisms and tumour cells), towards M2 (healing) macrophages (which have high arginase levels and produce ornithine to promote host-cell growth and collagen formation).	Ornithine	383-392	inositol polyphosphate-5-phosphatase D	Mus musculus	113-118
15190062-2	2004	The virus encodes a homolog of eukaryotic ornithine decarboxylase (ODC) that was previously demonstrated to be capable of decarboxylating l-ornithine.	Ornithine	138-149	ornithine decarboxylase 1	Homo sapiens	67-70
15190062-3	2004	However, the active site of this enzyme contains a key amino acid substitution (Glu for Asp) of a residue that interacts with the delta-amino group of ornithine analogs in the x-ray structures of ODC.	Ornithine	151-160	ornithine decarboxylase 1	Homo sapiens	196-199
15064231-6	2004	Colonocytes recovered from the P58 group were characterized at that time and thereafter by an increased capacity for l-ornithine and urea production through arginase (P < 0.05).	Ornithine	117-128	protein disulfide isomerase family A, member 3	Rattus norvegicus	31-34
15265947-2	2004	Importantly, arginase synthesizes ornithine, which is metabolized by the enzyme ornithine decarboxylase (ODC) to produce polyamines.	Ornithine	34-43	ornithine decarboxylase, structural 1	Mus musculus	80-103
15265947-2	2004	Importantly, arginase synthesizes ornithine, which is metabolized by the enzyme ornithine decarboxylase (ODC) to produce polyamines.	Ornithine	34-43	ornithine decarboxylase, structural 1	Mus musculus	105-108
14871882-0	2004	Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II.	Ornithine	0-9	ornithine aminotransferase	Rattus norvegicus	80-106
14871882-0	2004	Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II.	Ornithine	0-9	arginase 2	Rattus norvegicus	111-122
14871882-1	2004	In the kidney, L-ornithine is reabsorbed along the proximal convoluted tubule (PCT), transported by basolateral carriers, and produced by arginase II (AII).	Ornithine	15-26	arginase 2	Rattus norvegicus	138-149
14871882-1	2004	In the kidney, L-ornithine is reabsorbed along the proximal convoluted tubule (PCT), transported by basolateral carriers, and produced by arginase II (AII).	Ornithine	15-26	arginase 2	Rattus norvegicus	151-154
14871882-18	2004	However, the coexpression of ODC, glutamate decarboxylase, and glutamine synthetase in PST suggests that L-ornithine can also be metabolized to putrescine, GABA, and L-glutamine.	Ornithine	105-116	ornithine decarboxylase 1	Rattus norvegicus	29-32
14871882-18	2004	However, the coexpression of ODC, glutamate decarboxylase, and glutamine synthetase in PST suggests that L-ornithine can also be metabolized to putrescine, GABA, and L-glutamine.	Ornithine	105-116	glutamate-ammonia ligase	Rattus norvegicus	34-57
14871882-18	2004	However, the coexpression of ODC, glutamate decarboxylase, and glutamine synthetase in PST suggests that L-ornithine can also be metabolized to putrescine, GABA, and L-glutamine.	Ornithine	105-116	glutamate-ammonia ligase	Rattus norvegicus	63-83
12807890-2	2003	Two isoforms of the human ornithine carrier, ORC1 and ORC2, have been identified by overexpression of the proteins in bacteria and by study of the transport properties of the purified proteins reconstituted into liposomes.	Ornithine	26-35	origin recognition complex subunit 1	Homo sapiens	45-49
14712329-13	2004	Experiments on the intracellular distribution and the effects of the arginase inhibitors ornithine and N(omega)-hydroxy-L-arginine (NOHA), suggested the presence of both arginase I and arginase II in rat submandibular gland.	Ornithine	89-98	arginase 2	Rattus norvegicus	185-196
15050972-3	2004	A mitochondrial form, AII, has been thought to be more widely expressed and to be involved in the biosynthesis of polyamines, the amino acids ornithine, proline, and glutamate and in the inflammatory process, among others.	Ornithine	142-151	NLR family pyrin domain containing 3	Homo sapiens	22-25
15638127-13	2004	High levels of ornithine were induced only upon IL-4 activation.	Ornithine	15-24	interleukin 4	Mus musculus	48-52
12859253-3	2003	Purified human ODC-catalysed ornithine decarboxylation is highly stereospecific.	Ornithine	29-38	ornithine decarboxylase 1	Homo sapiens	15-18
12859253-10	2003	D-DFMO was a more potent inhibitor (IC50 approximately 7.5 microM) when compared with D-ornithine (IC50 approximately 1.5 mM) of ODC-catalysed L-ornithine decarboxylation.	Ornithine	86-97	ornithine decarboxylase 1	Homo sapiens	129-132
12859253-10	2003	D-DFMO was a more potent inhibitor (IC50 approximately 7.5 microM) when compared with D-ornithine (IC50 approximately 1.5 mM) of ODC-catalysed L-ornithine decarboxylation.	Ornithine	143-154	ornithine decarboxylase 1	Homo sapiens	129-132
12923240-11	2003	The main roles of AI are regulation of arginine concentration by degrading arginine and production of ornithine for polyamine biosynthesis, but AI may not be the principal enzyme for regulating glutamate biosynthesis in tissues and cells.	Ornithine	102-111	arginase, liver	Mus musculus	18-20
14622413-5	2003	Furthermore, yeast cells lacking Agc1p were unable to grow on acetate and oleic acid, and had reduced levels of valine, ornithine and citrulline; in contrast they grew on ethanol.	Ornithine	120-129	citrin	Saccharomyces cerevisiae S288C	33-38
12807890-2	2003	Two isoforms of the human ornithine carrier, ORC1 and ORC2, have been identified by overexpression of the proteins in bacteria and by study of the transport properties of the purified proteins reconstituted into liposomes.	Ornithine	26-35	origin recognition complex subunit 2	Homo sapiens	54-58
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Ornithine	99-108	origin recognition complex subunit 2	Homo sapiens	0-4
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Ornithine	99-108	origin recognition complex subunit 1	Homo sapiens	36-40
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Ornithine	122-131	origin recognition complex subunit 2	Homo sapiens	0-4
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Ornithine	122-131	origin recognition complex subunit 1	Homo sapiens	36-40
12948741-7	2003	When ORNT2 is overexpressed transiently in cultured fibroblasts from HHH patients, it rescues the deficient ornithine metabolism in these cells.	Ornithine	108-117	solute carrier family 25 member 2	Homo sapiens	5-10
12774850-6	2003	In contrast, we identified polyamine biosynthesis as a cellular target of aspirin, since the treatment of HT-29 Glc(-/+) cells with aspirin reduced the flux of L-ornithine through ornithine decarboxylase, an effect that could not be explained by an acute action of the drug on the ornithine decarboxylase catalytic activity.	Ornithine	160-171	ornithine decarboxylase 1	Homo sapiens	180-203
12679340-1	2003	In the presence of ornithine and arginine, ornithine carbamoyltransferase (OTCase) and arginase form a one-to-one enzyme complex in which the activity of OTCase is inhibited whereas arginase remains catalytically active.	Ornithine	19-28	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	43-73
12679340-1	2003	In the presence of ornithine and arginine, ornithine carbamoyltransferase (OTCase) and arginase form a one-to-one enzyme complex in which the activity of OTCase is inhibited whereas arginase remains catalytically active.	Ornithine	19-28	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	75-81
12679340-1	2003	In the presence of ornithine and arginine, ornithine carbamoyltransferase (OTCase) and arginase form a one-to-one enzyme complex in which the activity of OTCase is inhibited whereas arginase remains catalytically active.	Ornithine	19-28	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	154-160
12679340-5	2003	In OTCase, mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine and impaired the interaction with arginase.	Ornithine	33-42	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	3-9
12679340-5	2003	In OTCase, mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine and impaired the interaction with arginase.	Ornithine	142-151	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	3-9
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Ornithine	160-169	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Ornithine	261-270	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	181-190	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	129-136
12709047-5	2003	In the liver, where arginine is hydrolyzed to form urea and ornithine, the ASS gene is highly expressed, and hormones and nutrients constitute the major regulating factors: (a) glucocorticoids, glucagon and insulin, particularly, control the expression of this gene both during development and adult life; (b) dietary protein intake stimulates ASS gene expression, with a particular efficiency of specific amino acids like glutamine.	Ornithine	60-69	argininosuccinate synthase 1	Homo sapiens	75-78
12579527-5	2003	The results indicate that arginine, citrulline and ornithine supplementation increased the flux of substrate through the reaction catalysed by glutamine synthetase, leading to increased glutamine production after an exhaustive bout of exercise, and of the mechanism involved in ammonia buffering.	Ornithine	51-60	glutamate-ammonia ligase	Rattus norvegicus	143-163
12631327-2	2003	The arg11 mutant requires arginine (Arg) supplementation because it fails to export sufficient ornithine from the mitochondrion to the cytosol where it is converted to arginine.	Ornithine	95-104	Ort1p	Saccharomyces cerevisiae S288C	4-9
12631327-4	2003	The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity).	Ornithine	191-200	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	37-44
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	181-190	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	141-148
12631327-7	2003	AtmBAC1 appeared to be more stereospecific than the yeast and mammalian ornithine carriers, exhibiting greater preference for the l-forms of arginine, lysine and ornithine.	Ornithine	162-171	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-7
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	181-190	Ort1p	Saccharomyces cerevisiae S288C	205-210
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	181-190	Ort1p	Saccharomyces cerevisiae S288C	226-232
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	192-195	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	129-136
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	192-195	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	141-148
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	192-195	Ort1p	Saccharomyces cerevisiae S288C	205-210
12631327-1	2003	We describe the identification and functional characterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, which are related to the yeast ornithine (Orn) carrier Ort1p, also known as Arg11p.	Ornithine	192-195	Ort1p	Saccharomyces cerevisiae S288C	226-232
12517306-5	2003	Ort1p/Arg11p is a member of the mitochondrial carrier family (MCF) essential for ornithine export from mitochondria.	Ornithine	81-90	Ort1p	Saccharomyces cerevisiae S288C	0-5
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Ornithine	145-154	arginase, liver	Mus musculus	45-55
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Ornithine	145-154	inositol polyphosphate-5-phosphatase D	Mus musculus	63-67
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Ornithine	145-154	nitric oxide synthase 2, inducible	Mus musculus	106-110
12546703-9	2003	This suggests that the chronically elevated PI-3,4,5-P(3) levels in SHIP(-/-) mice may convert M1 (killing) macrophages, which produce NO to kill micro-organisms and tumour cells, into M2 (healing) macrophages, which produce ornithine to promote host cell growth and fibrosis.	Ornithine	225-234	inositol polyphosphate-5-phosphatase D	Mus musculus	68-72
12517306-5	2003	Ort1p/Arg11p is a member of the mitochondrial carrier family (MCF) essential for ornithine export from mitochondria.	Ornithine	81-90	Ort1p	Saccharomyces cerevisiae S288C	6-12
12019204-9	2002	Hence, L-arginine, which is irreversibly hydrolyzed to urea and ornithine by arginase, also induced hepatic CYP2E1.	Ornithine	64-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	108-114
12145284-8	2002	Exogenous l-ornithine did not inhibit NOHA-induced caspase-8 activation and cleavage of BH(3) interacting domain but acted at the mitochondrial level and inhibited the NOHA-induced cytochrome c release and apoptosis.	Ornithine	10-21	cytochrome c, somatic	Homo sapiens	181-193
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Ornithine	51-60	growth hormone 1	Homo sapiens	76-90
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Ornithine	51-60	growth hormone 1	Homo sapiens	92-94
12061769-1	2002	The urea cycle, which involves enzymes located in both the mitochondrion and cytoplasm, requires transport of ornithine and citrulline across the mitochondrial membrane by the ornithine/citrulline antiporter ORNT1.	Ornithine	110-119	solute carrier family 25 member 15	Rattus norvegicus	208-213
12061769-1	2002	The urea cycle, which involves enzymes located in both the mitochondrion and cytoplasm, requires transport of ornithine and citrulline across the mitochondrial membrane by the ornithine/citrulline antiporter ORNT1.	Ornithine	176-185	solute carrier family 25 member 15	Rattus norvegicus	208-213
11742824-1	2002	Polyamines are essential for cell proliferation; therefore, we hypothesized that arginase I or arginase II activities, via production of ornithine for polyamine synthesis, may be limiting for proliferation of endothelial cells (EC).	Ornithine	137-146	arginase 2	Rattus norvegicus	95-106
11971019-4	2002	Arginase competes with iNOS by converting L-arginine to L-ornithine.	Ornithine	56-67	nitric oxide synthase 2, inducible	Mus musculus	23-27
11736657-5	2001	Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively.	Ornithine	72-83	ornithine decarboxylase 1	Homo sapiens	19-22
11736657-5	2001	Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively.	Ornithine	72-83	ornithine decarboxylase 1	Homo sapiens	48-51
11746358-3	2001	AII, in contrast, is predominantly mitochondrial, is more widely expressed, and is thought to function primarily to produce ornithine.	Ornithine	124-133	arginase type II	Mus musculus	0-3
11749046-0	2001	Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation.	Ornithine	147-156	guanidinoacetate N-methyltransferase	Homo sapiens	23-57
11698350-2	2001	These actions of NOHA were abolished in the presence of exogenous L-ornithine suggesting that a reduction in the intracellular polyamine content might be responsible for the activation of caspase-3 and apoptotic actions of NOHA.	Ornithine	66-77	caspase 3	Homo sapiens	188-197
11534936-1	2001	BACKGROUND AND AIMS: L-Arg is the substrate for nitric oxide, and also for L-ornithine which, in turn, is the precursor for the synthesis of collagen and polyamines.	Ornithine	75-86	Rho guanine nucleotide exchange factor 12	Rattus norvegicus	21-26
11533243-1	2001	Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell growth, differentiation, transformation, and apoptosis.	Ornithine	83-92	ornithine decarboxylase, structural 1	Mus musculus	108-111
11370664-1	2001	Human type II arginase, which is extrahepatic and mitochondrial in location, catalyzes the hydrolysis of arginine to form ornithine and urea.	Ornithine	122-131	arginase 2	Homo sapiens	6-22
11514144-0	2001	Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.	Ornithine	112-121	prolylcarboxypeptidase	Homo sapiens	61-85
11470919-1	2001	Arginase, which exists as the isoforms arginase I and II, catalyzes the hydrolysis of arginine to ornithine and urea.	Ornithine	98-107	arginase 2	Rattus norvegicus	39-56
11370664-8	2001	Ornithine, a product of the reaction catalyzed by arginase and a potent inhibitor of type I arginase, is a poor inhibitor of the type II isozyme.	Ornithine	0-9	arginase 1	Homo sapiens	85-100
11388776-1	2001	A new technique for controllable elevation of night time growth hormone (GH) release in adult humans involves a synergy between oral intake of the naturally occurring compounds acetyl-L-carnitine (500 mg) and L-ornithine (25-100 mg) taken at night time sleep after a 3 to 4 hour fast.	Ornithine	209-220	growth hormone 1	Homo sapiens	57-71
11388776-1	2001	A new technique for controllable elevation of night time growth hormone (GH) release in adult humans involves a synergy between oral intake of the naturally occurring compounds acetyl-L-carnitine (500 mg) and L-ornithine (25-100 mg) taken at night time sleep after a 3 to 4 hour fast.	Ornithine	209-220	growth hormone 1	Homo sapiens	73-75
11297744-0	2001	CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes.	Ornithine	76-85	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	0-35
11297744-6	2001	Therefore, C/EBPbeta is required for hormonal induction of the genes for ornithine cycle enzymes in primary-cultured hepatocytes, while the deficiency of C/EBPbeta is compensated for in vivo.	Ornithine	73-82	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	11-20
11247829-1	2001	Because L-arginine is degraded by hepatic arginase to ornithine and urea and is transported by the regulated 2A cationic amino acid y(+) transporter (CAT2A), hepatic transport may regulate plasma arginine concentration.	Ornithine	54-63	solute carrier family 7 member 2	Rattus norvegicus	150-155
11276280-1	2001	Ornithine transcarbamylase (OTC) is a mitochondrial-matrix enzyme that catalyzes conversion of ornithine and carbamyl phosphate to citrulline, the second step in the urea cycle.	Ornithine	95-104	ornithine transcarbamylase	Homo sapiens	0-26
11276280-1	2001	Ornithine transcarbamylase (OTC) is a mitochondrial-matrix enzyme that catalyzes conversion of ornithine and carbamyl phosphate to citrulline, the second step in the urea cycle.	Ornithine	95-104	ornithine transcarbamylase	Homo sapiens	28-31
11231463-15	2001	Arginase and NOS 2 may compete for available arginine as a substrate, thereby limiting later NO production in favor of sustained ornithine synthesis.	Ornithine	129-138	nitric oxide synthase 2	Sus scrofa	13-18
11261568-12	2001	These results indicate that kidney arginase was readily activated by Arg provided in the water, resulting in an immediate increase in plasma urea and ornithine.	Ornithine	150-159	arginase 2	Homo sapiens	28-43
11259671-5	2001	The cytostatic action of the NO donor agents as well as alpha-difluoromethylornithine (DFMO), a known ODC inhibitor, was prevented by addition of putrescine but not ornithine.	Ornithine	76-85	ornithine decarboxylase 1	Homo sapiens	102-105
11244354-4	2001	High doses of ornithine (0.5 M) reduced while low doses (0.02 M) enhanced the ERG amplitudes.	Ornithine	14-23	ETS transcription factor ERG	Rattus norvegicus	78-81
11244354-7	2001	We conclude that the effect of ornithine on retinal function is dose dependent and can either enhance or depress the ERG amplitudes.	Ornithine	31-40	ETS transcription factor ERG	Rattus norvegicus	117-120
11222476-5	2001	TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity.	Ornithine	28-39	transforming growth factor beta 1	Homo sapiens	0-11
11222476-5	2001	TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity.	Ornithine	28-39	ornithine decarboxylase 1	Homo sapiens	64-87
11222476-5	2001	TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity.	Ornithine	28-39	ornithine decarboxylase 1	Homo sapiens	89-92
11222476-5	2001	TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity.	Ornithine	28-39	ornithine aminotransferase	Homo sapiens	98-124
11007319-0	2000	Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase.	Ornithine	0-9	ornithine decarboxylase, structural 1	Mus musculus	69-92
10964926-8	2000	It was found that the putrescine and ornithine recognition site on PotE is located at the cytoplasmic surface and the vestibule of the pore consisting of 12 transmembrane segments.	Ornithine	37-46	POTE ankyrin domain family member D	Homo sapiens	67-71
10993224-8	2000	These results demonstrate that the potent inhibitory activities of N(omega)-masked ornithine analogs against the growth of Meth A cells and methotrexate-resistant CCRF-CEM cells, results from effective uptake via reduced folate carrier and their potent DHFR inhibition.	Ornithine	83-92	dihydrofolate reductase	Homo sapiens	253-257
11275413-1	2001	The opioids heroin, methadone, buprenorphine, and morphine produce supraspinal antinociception in CD-1 mice that is antagonized by Cys(2), Tyr(3), Orn(5), Pen(7)-amide but not by naltrindole or nor-binaltorphimine.	Ornithine	147-150	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	155-158
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Ornithine	28-37	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	234-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	234-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11007319-0	2000	Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase.	Ornithine	0-9	ornithine aminotransferase	Mus musculus	97-123
11007319-2	2000	The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT).	Ornithine	105-114	ornithine decarboxylase, structural 1	Mus musculus	127-150
11007319-2	2000	The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT).	Ornithine	105-114	ornithine decarboxylase, structural 1	Mus musculus	152-155
11007319-2	2000	The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT).	Ornithine	105-114	ornithine aminotransferase	Mus musculus	161-187
10952667-2	2000	Since cNOS and arginase, which hydrolyzes L-arginine to L-ornithine and urea, use L-arginine as a common substrate, competition between both enzymes for the substrate could be involved in the regulation of cholinergic airway reactivity.	Ornithine	56-67	nitric oxide synthase, endothelial	Cavia porcellus	6-10
10913040-1	2000	This study was conducted to determine a role for cortisol in regulating intestinal ornithine decarboxylase (ODC) activity and to identify the metabolic sources of ornithine for intestinal polyamine synthesis in suckling pigs.	Ornithine	83-92	ornithine decarboxylase 1	Sus scrofa	108-111
10865171-0	2000	Ornithine-containing lipids stimulate CD14-dependent TNF-alpha production from murine macrophage-like J774.1 and RAW 264.7 cells.	Ornithine	0-9	CD14 antigen	Mus musculus	38-42
10918219-2	2000	L-arginine is known to be metabolized by one of two pathways: nitric oxide synthase (NOS), producing nitric oxide (NO), or arginase, producing ornithine.	Ornithine	143-152	nitric oxide synthase 2	Homo sapiens	62-83
10865172-0	2000	Modulation of chemotaxis, O(2)(-) production and myeloperoxidase release from human polymorphonuclear leukocytes by the ornithine-containing lipid and the serineglycine-containing lipid of Flavobacterium.	Ornithine	120-129	myeloperoxidase	Homo sapiens	49-64
10865171-0	2000	Ornithine-containing lipids stimulate CD14-dependent TNF-alpha production from murine macrophage-like J774.1 and RAW 264.7 cells.	Ornithine	0-9	tumor necrosis factor	Mus musculus	53-62
10935781-7	2000	More positive/less negative levels of alanine, aspartate, glutamine, glycine, ornithine, taurine and tyrosine were found in all the insulin-treated patients.	Ornithine	78-87	insulin	Homo sapiens	132-139
10843666-3	2000	In marked contrast, LPS stimulates Th2, but not Th1, macrophages to increase arginine metabolism to ornithine.	Ornithine	100-109	heart and neural crest derivatives expressed 2	Mus musculus	35-38
10843666-5	2000	Because NO inhibits cell division, while ornithine can stimulate cell division (via polyamines), these results also indicate that M-1 and M-2 responses can influence inflammatory reactions in opposite ways.	Ornithine	41-50	cholinergic receptor, muscarinic 2, cardiac	Mus musculus	138-141
10715561-5	2000	The selective V(1) agonist [Phe(2), Ile(3), Orn(8)]-vasopressin caused a significant increase in filopodial length, whereas the selective V(2) agonist [deamino-Cys(1), D-Arg(8)]-vasopressin showed no such effect.	Ornithine	44-47	arginine vasopressin	Homo sapiens	52-63
10800966-3	2000	ADC decarboxylates both arginine (Km = 0.75 mM) and ornithine (Km = 0.25 mM), a reaction not inhibited by the specific ODC inhibitor, difluoromethylomithine.	Ornithine	52-61	antizyme inhibitor 2	Rattus norvegicus	0-3
10623504-2	2000	Ornithine decarboxylase (ODC, EC 4.1.1.17) performs the first step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine.	Ornithine	117-126	ornithine decarboxylase 1	Homo sapiens	0-23
10655512-1	2000	Deficiency of ornithine-delta-aminotransferase (OAT) in humans results in gyrate atrophy of the choroid and retina (GA), an autosomal recessive disorder characterized by ornithine accumulation and a progressive chorioretinal degeneration of unknown pathogenesis.	Ornithine	14-23	ornithine aminotransferase	Mus musculus	48-51
10652239-2	2000	It is synthesized by the first four enzymes of the cycle, carbamylphosphate synthetase I, ornithine transcarbamylase, argininosuccinate synthetase, and argininosuccinate lyase, and is hydrolyzed to urea and ornithine by arginase I, forming the cycle.	Ornithine	90-99	argininosuccinate lyase	Rattus norvegicus	152-175
10623504-2	2000	Ornithine decarboxylase (ODC, EC 4.1.1.17) performs the first step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine.	Ornithine	117-126	ornithine decarboxylase 1	Homo sapiens	25-28
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Ornithine	275-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
11198268-1	2000	This study was performed to determine whether a single oral dose of ornithine (Orn), the substrate of ornithine decarboxylase (ODC), increases blood concentrations of polyamines premalignant stage, and whether blood polyamine levels could be used as predictive markers of cancer development.	Ornithine	68-77	ornithine decarboxylase 1	Rattus norvegicus	102-125
11198268-1	2000	This study was performed to determine whether a single oral dose of ornithine (Orn), the substrate of ornithine decarboxylase (ODC), increases blood concentrations of polyamines premalignant stage, and whether blood polyamine levels could be used as predictive markers of cancer development.	Ornithine	68-77	ornithine decarboxylase 1	Rattus norvegicus	127-130
11198268-1	2000	This study was performed to determine whether a single oral dose of ornithine (Orn), the substrate of ornithine decarboxylase (ODC), increases blood concentrations of polyamines premalignant stage, and whether blood polyamine levels could be used as predictive markers of cancer development.	Ornithine	79-82	ornithine decarboxylase 1	Rattus norvegicus	102-125
11198268-1	2000	This study was performed to determine whether a single oral dose of ornithine (Orn), the substrate of ornithine decarboxylase (ODC), increases blood concentrations of polyamines premalignant stage, and whether blood polyamine levels could be used as predictive markers of cancer development.	Ornithine	79-82	ornithine decarboxylase 1	Rattus norvegicus	127-130
10561504-2	1999	We report here the isolation of a T-DNA-tagged mutant displaying sensitivity to ornithine, whose characterization has allowed for the identification of several complementary and genomic DNA clones encoding the OTC and auxilin-like 1 (AUL1) proteins of the crucifer Arabidopsis thaliana.	Ornithine	80-89	ornithine carbamoyltransferase	Arabidopsis thaliana	210-213
10561504-2	1999	We report here the isolation of a T-DNA-tagged mutant displaying sensitivity to ornithine, whose characterization has allowed for the identification of several complementary and genomic DNA clones encoding the OTC and auxilin-like 1 (AUL1) proteins of the crucifer Arabidopsis thaliana.	Ornithine	80-89	auxin-like 1 protein	Arabidopsis thaliana	218-232
10561504-2	1999	We report here the isolation of a T-DNA-tagged mutant displaying sensitivity to ornithine, whose characterization has allowed for the identification of several complementary and genomic DNA clones encoding the OTC and auxilin-like 1 (AUL1) proteins of the crucifer Arabidopsis thaliana.	Ornithine	80-89	auxin-like 1 protein	Arabidopsis thaliana	234-238
10586514-3	1999	We have succeeded in converting S. ruminantium LDC to an enzyme with a preference in decarboxylating activity for L-ornithine when the four-residue of LDC were replaced by the corresponding residues of mouse ornithine decarboxylase (EC 4.1.1.17).	Ornithine	114-125	ornithine decarboxylase, structural 1	Mus musculus	208-231
10479284-0	1999	5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase.	Ornithine	68-77	folylpolyglutamate synthase	Homo sapiens	129-158
10387054-4	1999	However, LysRS possesses an efficient pre-transfer editing mechanism which prevents misacylation of tRNALys with ornithine.	Ornithine	113-122	lysyl-tRNA synthetase 1	Homo sapiens	9-14
10369256-1	1999	Neurospora crassa ARG13 and Saccharomyces cerevisiae ARG11 encode mitochondrial carrier family (MCF) proteins that transport ornithine across the mitochondrial inner membrane.	Ornithine	125-134	Ort1p	Saccharomyces cerevisiae S288C	53-58
10369256-4	1999	ORNT1 expression restores ornithine metabolism in fibroblasts from patients with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome.	Ornithine	26-35	solute carrier family 25 member 15	Homo sapiens	0-5
10502831-3	1999	In the OTC amino acid sequence, I172 and G197 are proximate to residues involved in catalysis, and G188 is within a loop joining helix 5 and strand 6 in the core of the ornithine-bindingdomain.	Ornithine	169-178	ornithine transcarbamylase	Homo sapiens	7-10
10037775-10	1999	We found that both confer P5CS activity and that the short isoform is inhibited by L-ornithine with a Ki of approximately 0.25 mM.	Ornithine	83-94	aldehyde dehydrogenase 18 family member A1	Homo sapiens	26-30
10037775-12	1999	Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine.	Ornithine	102-113	aldehyde dehydrogenase 18 family member A1	Homo sapiens	85-89
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Ornithine	275-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10050048-1	1999	Arginase, which catalyzes the conversion of arginine to urea and ornithine, and consists of a liver-type (arginase I) and a non-hepatic type (arginase II).	Ornithine	65-74	arginase 2	Rattus norvegicus	124-153
10050048-10	1999	The co-localization of arginase II and the three ornithine-utilizing enzymes in the small intestine suggests that the enzyme is involved in the synthesis of proline, polyamines, and/or citrulline in this tissue.	Ornithine	49-58	arginase 2	Rattus norvegicus	23-34
9874237-1	1998	In this work we have characterised the transport of L-arginine and L-ornithine into mitochondria isolated from a wild-type Saccharomyces cerevisiae strain and an isogenic arg11 knock-out mutant.	Ornithine	67-78	Ort1p	Saccharomyces cerevisiae S288C	171-176
10668504-14	1999	They are synthesised from putrescine, which is a key regulatory molecule formed from ornithine by ornithine decarboxylase, a highly inducible and regulated enzyme.	Ornithine	85-94	ornithine decarboxylase 1	Homo sapiens	98-121
10353628-8	1999	The cardiac ODC from controls as well as clenbuterol treated mice exhibited similar affinity (Km) for its substrate, ornithine, while maximum enzyme activity (Vmax) was about 14 fold higher in clenbuterol treated mouse heart than in the control.	Ornithine	117-126	ornithine decarboxylase, structural 1	Mus musculus	12-15
9874237-8	1998	Evidence is presented here that the mitochondrial inner membrane contains an L-arginine and L-ornithine transporting system distinct from Arg11p, in keeping with the arginine leaky phenotype of arg11 knock-out mutants.	Ornithine	92-103	Ort1p	Saccharomyces cerevisiae S288C	194-199
9765281-0	1998	Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice.	Ornithine	72-81	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	104-114
9765281-4	1998	Here we examined the expression of ornithine cycle enzyme genes in the livers of C/EBPalpha-deficient mice.	Ornithine	35-44	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	81-91
9765281-9	1998	Thus, C/EBPalpha is crucial for ammonia detoxification by ornithine cycle enzymes and for coordination of gluconeogenesis and urea synthesis.	Ornithine	58-67	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	6-16
9745037-1	1998	Mammals contain two genes encoding distinct isoforms of arginase (arginases I and II), both of which catalyze the conversion of arginine to ornithine and urea.	Ornithine	140-149	arginase, liver	Mus musculus	35-84
9874001-2	1998	It is synthesized from ornithine by argininosuccinate synthetase and argininosuccinate lyase and is degraded by arginase, which consists of a liver-type (arginase I) and a non-hepatic type (arginase II).	Ornithine	23-32	arginase 2	Rattus norvegicus	172-201
9686762-2	1998	Since L-ornithine is metabolized to growth-stimulatory polyamines, we examined whether thrombin regulates the transcellular transport and metabolism of L-ornithine by vascular SMCs.	Ornithine	152-163	coagulation factor II, thrombin	Homo sapiens	87-95
9686762-3	1998	Treatment of SMCs with thrombin initially (0 to 2 hours) decreased L-ornithine uptake, whereas longer exposures (6 to 24 hours) progressively increased transport.	Ornithine	67-78	coagulation factor II, thrombin	Homo sapiens	23-31
9686762-7	1998	The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide.	Ornithine	43-54	coagulation factor II, thrombin	Homo sapiens	109-117
9686762-4	1998	Kinetic studies indicated that thrombin-induced inhibition was associated with a decrease in affinity for L-ornithine, whereas stimulation was mediated by an increase in transport capacity.	Ornithine	106-117	coagulation factor II, thrombin	Homo sapiens	31-39
9686762-8	1998	Thrombin also markedly increased the capacity of SMCs to generate putrescine, a polyamine, from extracellular L-ornithine.	Ornithine	110-121	coagulation factor II, thrombin	Homo sapiens	0-8
9686762-6	1998	Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity.	Ornithine	33-44	coagulation factor II, thrombin	Homo sapiens	13-21
9686762-12	1998	The ability of thrombin to upregulate L-ornithine transport and direct its metabolism to growth-stimulatory polyamines may contribute to postangioplasty restenosis and atherosclerotic lesion formation.	Ornithine	38-49	coagulation factor II, thrombin	Homo sapiens	15-23
9686762-6	1998	Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity.	Ornithine	33-44	ornithine decarboxylase 1	Homo sapiens	68-91
9686762-6	1998	Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity.	Ornithine	33-44	ornithine decarboxylase 1	Homo sapiens	93-96
9686762-7	1998	The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide.	Ornithine	43-54	coagulation factor II, thrombin	Homo sapiens	26-34
9686762-7	1998	The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by hirudin, a thrombin inhibitor, and was mimicked by a 14-amino acid thrombin receptor-activating peptide.	Ornithine	43-54	coagulation factor II, thrombin	Homo sapiens	109-117
9428669-2	1997	While forming ornithine, this enzyme regenerates acetylglutamate, also produced in the first step by the ARG2-encoded acetylglutamate synthase.	Ornithine	14-23	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	105-109
9657970-1	1998	Ornithine decarboxylase (ODC) catalyses the conversion of ornithine to putrescine, an obligate precursor to the polyamines spermidine and spermine.	Ornithine	58-67	Ornithine decarboxylase	Caenorhabditis elegans	0-23
9657970-1	1998	Ornithine decarboxylase (ODC) catalyses the conversion of ornithine to putrescine, an obligate precursor to the polyamines spermidine and spermine.	Ornithine	58-67	Ornithine decarboxylase	Caenorhabditis elegans	25-28
9734336-7	1998	The co-localization of CPS I and OCT and a high activity of OCT in enterocyte mitochondria favors the intestinal synthesis of citrulline from ammonia, HCO3- and ornithine.	Ornithine	161-170	ornithine transcarbamylase	Sus scrofa	33-36
9734336-7	1998	The co-localization of CPS I and OCT and a high activity of OCT in enterocyte mitochondria favors the intestinal synthesis of citrulline from ammonia, HCO3- and ornithine.	Ornithine	161-170	ornithine transcarbamylase	Sus scrofa	60-63
9468343-9	1998	After 4 days of treatment with 100 mM L-valine, L-ornithine flux through ornithine decarboxylase was significantly higher as well as putrescine and spermidine cellular uptakes in treated cells.	Ornithine	48-59	ornithine decarboxylase 1	Homo sapiens	73-96
9719479-4	1998	L-ornithine, a substrate for ODC, retroinhibits arginase.	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	29-32
9719479-11	1998	The inhibitory effect of DFMO upon arginase, one step upstream of the ODC reaction in the metabolic conversion of L-arginine to polyamines, is of potential physiological importance, since it could alter the production of ornithine and thus its metabolism in pathways other than the ODC pathway.	Ornithine	221-230	ornithine decarboxylase 1	Homo sapiens	70-73
9719479-11	1998	The inhibitory effect of DFMO upon arginase, one step upstream of the ODC reaction in the metabolic conversion of L-arginine to polyamines, is of potential physiological importance, since it could alter the production of ornithine and thus its metabolism in pathways other than the ODC pathway.	Ornithine	221-230	ornithine decarboxylase 1	Homo sapiens	282-285
9514741-1	1998	Ornithine aminotransferase (OAT), a pyridoxal-5"-phosphate dependent enzyme, catalyses the transfer of the delta-amino group of L-ornithine to 2-oxoglutarate, producing L-glutamate-gamma-semialdehyde, which spontaneously cyclizes to pyrroline-5-carboxylate, and L-glutamate.	Ornithine	128-139	ornithine aminotransferase	Homo sapiens	0-26
9514741-1	1998	Ornithine aminotransferase (OAT), a pyridoxal-5"-phosphate dependent enzyme, catalyses the transfer of the delta-amino group of L-ornithine to 2-oxoglutarate, producing L-glutamate-gamma-semialdehyde, which spontaneously cyclizes to pyrroline-5-carboxylate, and L-glutamate.	Ornithine	128-139	ornithine aminotransferase	Homo sapiens	28-31
9480841-2	1998	Ornithine decarbolylase (ODC) catalyzes the first step of polyamine biosynthesis converting ornithine to putrescine.	Ornithine	92-101	ornithine decarboxylase 1	Homo sapiens	0-23
9480841-2	1998	Ornithine decarbolylase (ODC) catalyzes the first step of polyamine biosynthesis converting ornithine to putrescine.	Ornithine	92-101	ornithine decarboxylase 1	Homo sapiens	25-28
9428669-3	1997	Interestingly, total deletion of the genomic ARG7 ORF resulted in an arginine-leaky phenotype, indicating that yeast cells possess an alternative route for generating ornithine from acetylornithine.	Ornithine	167-176	glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	45-49
9428669-13	1997	As with several bacterial ornithine acetyltransferases, the activity of Arg7p was practically insensitive to arginine but strongly inhibited by ornithine, which behaved as a competitive inhibitor.	Ornithine	26-35	glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	72-77
9401045-0	1997	Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR.	Ornithine	14-23	ornithine utilization transcriptional regulator OruR	Pseudomonas aeruginosa PAO1	113-117
9401045-8	1997	Definition of this oruR locus and its effects upon OAcT activity provide evidence that control of ornithine levels in P. aeruginosa may have a significant impact upon how the cell is able to monitor and regulate the use of arginine and glutamate as sources of either carbon or nitrogen.	Ornithine	98-107	ornithine utilization transcriptional regulator OruR	Pseudomonas aeruginosa PAO1	19-23
9415309-4	1997	This study was undertaken to determine the ornithine metabolizing capacity of epidermal keratinocytes expressing normal and superphysiologic amounts of OAT.	Ornithine	43-52	ornithine aminotransferase	Homo sapiens	152-155
9353942-9	1997	These data suggest that ORF3 encodes a protein involved in the biosynthesis of ornithine, a constituent of phaseolotoxin.	Ornithine	79-88	hypothetical protein	Escherichia coli	24-28
9415309-5	1997	The data show that overexpression of OAT in keratinocytes cultured from a gyrate atrophy patient restores ornithine metabolism and results in a rate of ornithine disappearance from the medium that is significantly higher than the rate of disappearance from the medium bathing normal keratinocytes.	Ornithine	106-115	ornithine aminotransferase	Homo sapiens	37-40
9415309-5	1997	The data show that overexpression of OAT in keratinocytes cultured from a gyrate atrophy patient restores ornithine metabolism and results in a rate of ornithine disappearance from the medium that is significantly higher than the rate of disappearance from the medium bathing normal keratinocytes.	Ornithine	152-161	ornithine aminotransferase	Homo sapiens	37-40
9415309-6	1997	In addition, OAT activity determined in soluble protein prepared from sonicates suggests that the capacity to maintain plasma ornithine within the normal range is contained within an accomplishable graft of keratinocytes overexpressing OAT.	Ornithine	126-135	ornithine aminotransferase	Homo sapiens	13-16
9237680-0	1997	Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis.	Ornithine	59-68	Ort1p	Saccharomyces cerevisiae S288C	28-34
9323687-10	1997	RESULTS: Both the enterocyte capacity to decarboxylate ornithine through ODC (measured in viable enterocytes) and ODC activity (measured in homogenates) were severely decreased in group ED.	Ornithine	55-64	ornithine decarboxylase 1	Rattus norvegicus	73-76
9309222-1	1997	BACKGROUND: Ornithine aminotransferase (OAT) is a 45 kDa pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the conversion of L-ornithine and 2-oxoglutarate to glutamate-delta-semialdehyde and glutamic acid, respectively.	Ornithine	136-147	ornithine aminotransferase	Homo sapiens	12-38
9309222-1	1997	BACKGROUND: Ornithine aminotransferase (OAT) is a 45 kDa pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the conversion of L-ornithine and 2-oxoglutarate to glutamate-delta-semialdehyde and glutamic acid, respectively.	Ornithine	136-147	ornithine aminotransferase	Homo sapiens	40-43
9309222-2	1997	In humans, loss of OAT function causes an accumulation of ornithine that results in gyrate atrophy of the choroid and retina, a disease that progressively leads to blindness.	Ornithine	58-67	ornithine aminotransferase	Homo sapiens	19-22
9309222-3	1997	In an effort to learn more about the structural basis of this enzyme"s function, we have determined the X-ray structures of OAT in complex with two enzyme-activated suicide substrates: L-canaline, an ornithine analog, and gabaculine, an irreversible inhibitor of several related aminotransferases.	Ornithine	200-209	ornithine aminotransferase	Homo sapiens	124-127
9309222-7	1997	CONCLUSIONS: The OAT-L-canaline complex structure implicates Tyr55 and Arg180 as the residues involved in coordinating with the natural substrate ornithine during normal enzyme turnover.	Ornithine	146-155	ornithine aminotransferase	Homo sapiens	17-20
9124567-7	1997	Compared with control, cortisol administration increased 1) the activities of ASL and arginase and the production of CO(2), ornithine, and proline from arginine, and 2) P5C synthase activity and the formation of glutamate, alanine, aspartate, ornithine, citrulline, proline, and CO(2) from glutamine in enterocytes.	Ornithine	124-133	argininosuccinate lyase	Sus scrofa	78-81
9013625-2	1997	The gene for liver-type arginase, an ornithine cycle enzyme, is induced by glucocorticoids in a delayed secondary manner.	Ornithine	37-46	arginase 1	Rattus norvegicus	13-32
9124321-4	1997	Transforming growth factor (TGF)-beta1 decreased IFN-gamma-stimulated NO synthase activity and produced a reciprocal increase in urea and ornithine release.	Ornithine	138-147	transforming growth factor, beta 1	Mus musculus	0-38
9124321-7	1997	However, Cort inhibited NO synthase activity and increased ornithine release in MPEC exposed to IFN-gamma or LPS.	Ornithine	59-68	cortistatin	Mus musculus	9-13
9124321-7	1997	However, Cort inhibited NO synthase activity and increased ornithine release in MPEC exposed to IFN-gamma or LPS.	Ornithine	59-68	interferon gamma	Mus musculus	96-105
8798783-1	1996	Prototype strain MG409 (arg11-1) is a severe arginine bradytroph with greatly reduced ornithine and arginine pools, although all known enzymes required for arginine biosynthesis are functional.	Ornithine	86-95	Ort1p	Saccharomyces cerevisiae S288C	24-29
8911353-4	1996	RESULTS: The SLC3A1 gene has been shown to code for a protein that, when expressed in Xenopus oocytes, confers on these cells the ability to transport cystine, arginine, lysine and ornithine.	Ornithine	181-190	solute carrier family 3 (amino acid transporter heavy chain), member 1 L homeolog	Xenopus laevis	13-19
9016354-6	1997	The substitution of Arg2 or Arg4 in FRCRCFa with lysine or ornithine decreases the inhibitory potency by 5-12-fold, suggesting that both arginines are beneficial for inhibition.	Ornithine	59-68	arginase 2	Homo sapiens	20-24
9131018-3	1996	Liver arginase (L-arginine ureahydrolase, A1) is the fifth enzyme of the cycle, catalyzing the hydrolysis of arginine to ornithine and urea within the cytosol.	Ornithine	121-130	arginase 2	Homo sapiens	16-40
8798783-8	1996	As a working hypothesis, we propose that Arg11p participates in the export of matrix-made ornithine into the cytosol.	Ornithine	90-99	Ort1p	Saccharomyces cerevisiae S288C	41-47
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Ornithine	8-17	folylpolyglutamate synthase	Homo sapiens	106-134
8778603-1	1996	BACKGROUND: Ornithine transcarbamylase is an X-linked mitochondrial enzyme that catalyzes the synthesis of citrulline from carbamoyl phosphate and ornithine.	Ornithine	147-156	ornithine transcarbamylase	Homo sapiens	12-38
8662668-11	1996	The capacity of PDGF to up-regulate the transport of L-ornithine by inducing the expression of the genes for CAT-1 and CAT-2B may modulate its mitogenic effect by providing SMC with the necessary intracellular precursor for polyamine biosynthesis.	Ornithine	53-64	solute carrier family 7 member 1	Homo sapiens	109-114
8761662-5	1996	The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine.	Ornithine	197-206	aldehyde dehydrogenase 18 family member A1	Homo sapiens	42-46
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Ornithine	8-17	folylpolyglutamate synthase	Homo sapiens	136-140
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Ornithine	19-22	folylpolyglutamate synthase	Homo sapiens	106-134
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Ornithine	19-22	folylpolyglutamate synthase	Homo sapiens	136-140
8845305-0	1995	Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.	Ornithine	12-21	ornithine decarboxylase, structural 1	Mus musculus	98-121
8983332-1	1996	Polyamines (PA) are derived from ornithine by the enzyme ornithine decarboxylase (ODC), which is activated very rapidly as acute and delayed responses to brain ischemia and trauma.	Ornithine	33-42	ornithine decarboxylase 1	Rattus norvegicus	57-80
8983332-1	1996	Polyamines (PA) are derived from ornithine by the enzyme ornithine decarboxylase (ODC), which is activated very rapidly as acute and delayed responses to brain ischemia and trauma.	Ornithine	33-42	ornithine decarboxylase 1	Rattus norvegicus	82-85
7780833-12	1995	The study showed testosterone-induced differential changes in the activity of two enzymes involved in ornithine biosynthesis and catabolism which accompanied ODC induction in female mouse kidney.	Ornithine	102-111	ornithine decarboxylase, structural 1	Mus musculus	158-161
8544185-4	1995	The binding sites for carbamyl phosphate in both enzymes are similar and the ornithine binding site in ornithine transcarbamylase appears to be in the same location as the L-aspartate binding site in aspartate transcarbamylase, with negatively charged side chains replaced by positively charged residues.	Ornithine	77-86	ornithine transcarbamylase	Homo sapiens	103-129
7608905-4	1995	On the basis of molecular modeling with AMBER, we prepared the lactam cyclo-[D-Asp2,Dap5]Dyn A-(1-13)NH2 (1; Dap = alpha, beta-diaminopropionic acid) containing a four-atom bridge between positions 2 and 5 as a possible constraint compatible with an alpha-helix, along with the homologues with five-(2) and six-atom (3) bridges containing Dab (alpha, gamma-diaminobutyric acid) and Orn, respectively, in position 5.	Ornithine	382-385	death-associated protein 1	Cavia porcellus	84-87
7608905-8	1995	Novel byproducts were also obtained from the cyclization reactions with HBTU (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) and characterized as [D-Asp2,X(Tmg)5]Dyn A-(1-13)NH2 (where X = Dap, Dab, or Orn and Tmg = tetramethylguanidinium).	Ornithine	228-231	death-associated protein 1	Cavia porcellus	215-218
7792296-0	1995	Evidence for the role of pancreatic acinar cells in the production of ornithine and guanidinoacetic acid by L-arginine:glycine amidinotransferase.	Ornithine	70-79	glycine amidinotransferase	Rattus norvegicus	108-145
7792296-9	1995	Transamidinase activity in the isolated perfused pancreas was determined by measuring the amount of ornithine released into the perfusate.	Ornithine	100-109	glycine amidinotransferase	Rattus norvegicus	0-14
7792296-10	1995	The transamidinase activity of the perfused pancreas was 16.4 +/- 1.8 U/g pancreas and is an estimate of the physiological production capacity of the enzyme (270 +/- 29 nmol ornithine/min/g pancreas).	Ornithine	174-183	glycine amidinotransferase	Rattus norvegicus	4-18
7893672-0	1995	Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.	Ornithine	120-129	coagulation factor II, thrombin	Homo sapiens	40-48
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Ornithine	299-310	interleukin 4 induced 1	Homo sapiens	75-120
7929646-1	1994	Polyamines are derived from ornithine by the actions of ornithine decarboxylase (ODC), which is the rate-limiting step in this pathway.	Ornithine	28-37	ornithine decarboxylase 1	Homo sapiens	56-79
7929646-1	1994	Polyamines are derived from ornithine by the actions of ornithine decarboxylase (ODC), which is the rate-limiting step in this pathway.	Ornithine	28-37	ornithine decarboxylase 1	Homo sapiens	81-84
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Ornithine	299-310	interleukin 4 induced 1	Homo sapiens	122-125
7828023-1	1994	Ornithine transcarbamylase (OTC) is a mitochondrial enzyme which catalyzes the conversion of ornithine into citrulline.	Ornithine	93-102	ornithine transcarbamylase	Mus musculus	0-26
7828023-1	1994	Ornithine transcarbamylase (OTC) is a mitochondrial enzyme which catalyzes the conversion of ornithine into citrulline.	Ornithine	93-102	ornithine transcarbamylase	Mus musculus	28-31
7896732-1	1994	The gene for rat argininosuccinate lyase (AL), which catalyzes the last step of arginine biosynthesis, is expressed in many tissues, though its expression is much higher in the liver where the enzyme is involved in the ornithine cycle (urea cycle), and moderately higher in the kidney.	Ornithine	219-228	argininosuccinate lyase	Rattus norvegicus	17-40
7707692-3	1994	Selective inactivation of ornithine aminotransferase (OAT) by 5-fluoromethylornithine raises endogenous ornithine concentrations so that citrulline formation is effectively catalysed by the aberrant OCT, in spite of its low affinity for ornithine.	Ornithine	26-35	ornithine transcarbamylase	Homo sapiens	199-202
8186261-6	1994	When insulin and ornithine were administered together, even higher levels of intracellular putrescine and putrescine export were observed, with putrescine efflux proceeding over the 36 h time-course at the highest observed rates of 1.5 (0-12 h) and 1.0 (12-36 h) nmol/mg total protein per h. Exposure to DFMO, an inhibitor of ODC, depleted intracellular putrescine stores and effectively suppressed putrescine export.	Ornithine	17-26	ornithine decarboxylase 1	Rattus norvegicus	326-329
8192245-6	1994	The coexpression of glutaminase, glutamate dehydrogenase, and carbamoylphosphate synthase, but not of arginase, in the mesonephros and the small intestine suggests that these organs are involved in the biosynthesis of intermediates of the ornithine cycle, e.g., arginine or citrulline.	Ornithine	239-248	glutaminase	Homo sapiens	20-56
7998343-0	1994	[Receptor selectivity profile of short enkephalin analogs containing D-ornithine at the second position of the molecule].	Ornithine	69-80	proenkephalin	Rattus norvegicus	39-49
7998343-1	1994	The radioreceptor binding assay using a membrane fraction from the rat brain was applied to study binding activity and opiate receptor selectivity of truncated enkephalin analogs (with a free or modified C-terminal carboxyl group) bearing D-ornithine at the second position.	Ornithine	239-250	proenkephalin	Rattus norvegicus	160-170
7998343-5	1994	D-ornithine side chain prolongation by means of the attachment of some amino acid residues (methionine, leucine, proline, asparagine) led to the original branched enkephalin analogs.	Ornithine	0-11	proenkephalin	Rattus norvegicus	163-173
7948132-1	1994	Ornithine delta aminotransferase (OAT) is a nuclear-encoded mitochondrial matrix enzyme that catalyzes the reversible transamination of ornithine to glutamate semialdehyde.	Ornithine	136-145	ornithine aminotransferase	Homo sapiens	0-32
7948132-1	1994	Ornithine delta aminotransferase (OAT) is a nuclear-encoded mitochondrial matrix enzyme that catalyzes the reversible transamination of ornithine to glutamate semialdehyde.	Ornithine	136-145	ornithine aminotransferase	Homo sapiens	34-37
7707692-3	1994	Selective inactivation of ornithine aminotransferase (OAT) by 5-fluoromethylornithine raises endogenous ornithine concentrations so that citrulline formation is effectively catalysed by the aberrant OCT, in spite of its low affinity for ornithine.	Ornithine	76-85	ornithine aminotransferase	Mus musculus	26-52
7707692-3	1994	Selective inactivation of ornithine aminotransferase (OAT) by 5-fluoromethylornithine raises endogenous ornithine concentrations so that citrulline formation is effectively catalysed by the aberrant OCT, in spite of its low affinity for ornithine.	Ornithine	76-85	ornithine transcarbamylase	Homo sapiens	199-202
8281144-1	1993	Ornithine-delta-aminotransferase catalyzes the conversion of ornithine to glutamate-gamma-semialdehyde.	Ornithine	61-70	ornithine aminotransferase	Homo sapiens	0-32
8508705-4	1993	The response of microvillous enzymes (lactase, sucrase, maltase, and aminopeptidase) to spermine was dose-dependent and -specific since oral administration of arginine (5 mumol) or ornithine (5 mumol) was without effect.	Ornithine	181-190	lactase	Rattus norvegicus	38-45
8322890-13	1993	Thus Arg produced by PCT in both species is probably released in the cortical blood, whereas Arg produced in PST may serve locally to produce urea and ornithine, and the latter could be used for polyamine synthesis.	Ornithine	151-160	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	109-112
8457542-1	1993	A new photoreactive tritiated cholecystokinin (CCK) analogue was synthesized which contains the p-benzoylbenzoyl moiety linked to an ornithine residue at the N-terminus of the sulfated CCK octapeptide (CCK-8s).	Ornithine	133-142	cholecystokinin	Sus scrofa	47-50
8496174-2	1993	The gene for rat ornithine transcarbamylase (OTC), an ornithine cycle enzyme, is mainly expressed in the liver and is under the control of the promoter and the 11-kilobase upstream enhancer, both of which are liver-selective.	Ornithine	17-26	ornithine transcarbamylase	Rattus norvegicus	45-48
8457542-1	1993	A new photoreactive tritiated cholecystokinin (CCK) analogue was synthesized which contains the p-benzoylbenzoyl moiety linked to an ornithine residue at the N-terminus of the sulfated CCK octapeptide (CCK-8s).	Ornithine	133-142	cholecystokinin	Sus scrofa	185-188
8457542-1	1993	A new photoreactive tritiated cholecystokinin (CCK) analogue was synthesized which contains the p-benzoylbenzoyl moiety linked to an ornithine residue at the N-terminus of the sulfated CCK octapeptide (CCK-8s).	Ornithine	133-142	cholecystokinin	Sus scrofa	185-188
8495798-1	1993	Ornithine-delta-aminotransferase (OAT) catalyzes the reversible transamination of ornithine to glutamate semialdehyde.	Ornithine	82-91	ornithine aminotransferase	Homo sapiens	0-32
8462726-6	1993	Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC.	Ornithine	132-143	ornithine decarboxylase 1	Homo sapiens	127-130
8462726-6	1993	Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC.	Ornithine	132-143	ornithine decarboxylase 1	Homo sapiens	197-200
7682617-5	1993	Authentic NOHNMA, synthesized from L-ornithine, irreversibly inhibited both mNOS (k(inact) = 0.10 min-1) and bNOS in an NADPH-dependent reaction.	Ornithine	35-46	nitric oxide synthase 1, neuronal	Mus musculus	109-113
8462122-2	1993	The compounds competed with ornithine for the substrate binding site of ODC, but resulted in progressive and apparently irreversible inactivation of the enzyme.	Ornithine	28-37	ornithine decarboxylase 1	Homo sapiens	72-75
8495798-1	1993	Ornithine-delta-aminotransferase (OAT) catalyzes the reversible transamination of ornithine to glutamate semialdehyde.	Ornithine	82-91	ornithine aminotransferase	Homo sapiens	34-37
1486085-2	1992	We report the case of an 18-year-old female who presented with the typical features of HOGA, including posterior subcapsular cataracts and elevated plasma ornithine.	Ornithine	155-164	ornithine aminotransferase	Homo sapiens	87-91
1483266-1	1992	The increase in ODC activity during perifusion of Ehrlich carcinoma cells with 0.5 mM ornithine correlates with an increase in "de novo" synthetized ODC protein.	Ornithine	86-95	ornithine decarboxylase, structural 1	Mus musculus	16-19
1483266-1	1992	The increase in ODC activity during perifusion of Ehrlich carcinoma cells with 0.5 mM ornithine correlates with an increase in "de novo" synthetized ODC protein.	Ornithine	86-95	ornithine decarboxylase, structural 1	Mus musculus	149-152
20732162-2	1992	The activity of ODC was measured partially in situ by an assay method using (3)H-labelled ornithine and analysing of the labelled putrescine formed.	Ornithine	90-99	ornithine decarboxylase 1	Rattus norvegicus	16-19
1472981-0	1992	Ornithine and histidine decarboxylase activities in mice sensitized to endotoxin, interleukin-1 or tumour necrosis factor by D-galactosamine.	Ornithine	0-9	interleukin 1 complex	Mus musculus	82-95
1472981-0	1992	Ornithine and histidine decarboxylase activities in mice sensitized to endotoxin, interleukin-1 or tumour necrosis factor by D-galactosamine.	Ornithine	0-9	tumor necrosis factor	Mus musculus	99-121
1535833-1	1992	Previously we reported that 10 mM ornithine (Orn) selectively inhibits the development of CD8+ CTL in MLC.	Ornithine	34-43	CD8a molecule	Homo sapiens	90-93
1299499-2	1992	Three female and nine male bodybuilders served as subjects in a study to test the effectiveness of oral ornithine in bringing about the release of insulin, an anabolic hormone.	Ornithine	104-113	insulin	Homo sapiens	147-154
1535833-1	1992	Previously we reported that 10 mM ornithine (Orn) selectively inhibits the development of CD8+ CTL in MLC.	Ornithine	34-43	modulator of VRAC current 1	Homo sapiens	102-105
1535833-1	1992	Previously we reported that 10 mM ornithine (Orn) selectively inhibits the development of CD8+ CTL in MLC.	Ornithine	45-48	CD8a molecule	Homo sapiens	90-93
1535833-1	1992	Previously we reported that 10 mM ornithine (Orn) selectively inhibits the development of CD8+ CTL in MLC.	Ornithine	45-48	modulator of VRAC current 1	Homo sapiens	102-105
1376926-8	1992	(iii) The stimulation of sodium-independent uptake of L-arginine and the stimulation of sodium-dependent uptake of L-leucine induced by injection of 4F2hc cRNA are both completely inhibited by dibasic L amino acids and to a lesser extent by D-ornithine.	Ornithine	241-252	solute carrier family 3 member 2	Homo sapiens	149-154
1311296-11	1992	It is concluded that the ArcD protein is a transport system that catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway.	Ornithine	123-132	hypothetical protein	Escherichia coli	25-29
1743613-3	1991	Cells released from the hydroxyurea induced synchrony exhibited an increased rate of [3H] leucine incorporation in response to prolactin when ornithine, putrescine, or spermidine were present.	Ornithine	142-151	prolactin	Homo sapiens	127-136
1540132-5	1992	(1) The apparent Km values of matrix OCT for carbamoyl phosphate and ornithine are respectively 8 and 2 times those measured for the soluble enzyme.	Ornithine	69-78	ornithine transcarbamylase	Rattus norvegicus	37-40
1939349-2	1991	The initial step in polyamine biosynthesis normally involves the decarboxylation of ornithine by the enzyme ornithine decarboxylase (ODCase E.C.	Ornithine	84-93	ornithine decarboxylase 1	Rattus norvegicus	108-131
1939349-14	1991	In a manner identical to the serum-containing cultures (Wu and Byus (1984] the addition of TPA and exogenous ornithine to the serum-free cells caused a dose-dependent increase in intracellular putrescine (up to 5-fold) and a concomitant decrease in ODC activity in comparison to stimulation with TPA alone.	Ornithine	109-118	ornithine decarboxylase 1	Rattus norvegicus	249-252
1737786-2	1992	Ornithine delta-aminotransferase is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the reversible interconversion of ornithine and alpha-ketoglutarate to glutamate semialdehyde and glutamate.	Ornithine	132-141	ornithine aminotransferase	Homo sapiens	0-32
1872891-5	1991	On the contrary, N-acetylation paralleled with a decrease in the inhibition capacity: 55 microM N-acetyl putrescine, N-acetyl serotonin or N-omega-acetylhistamine suppressed ODC induction by ornithine in 66, 64 and 19%, respectively.	Ornithine	191-200	ornithine decarboxylase, structural 1	Mus musculus	174-177
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Ornithine	258-267	interferon gamma	Mus musculus	97-113
1872891-1	1991	Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine.	Ornithine	210-219	ornithine decarboxylase, structural 1	Mus musculus	0-23
1872891-1	1991	Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine.	Ornithine	210-219	ornithine decarboxylase, structural 1	Mus musculus	25-28
1872891-1	1991	Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine.	Ornithine	336-345	ornithine decarboxylase, structural 1	Mus musculus	0-23
1872891-1	1991	Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine.	Ornithine	336-345	ornithine decarboxylase, structural 1	Mus musculus	25-28
1872891-3	1991	The 1,4-diamines putrescine, spermidine, spermine, agmatine, histamine, serotonin, tryptamine, chlorpheniramine and harmaline at 55 microM strongly suppressed ODC induction by 0.5 mM ornithine in perifused Ehrlich ascites cells.	Ornithine	183-192	ornithine decarboxylase, structural 1	Mus musculus	159-162
1903327-2	1991	The highly inducible enzyme ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine as the initial step in polyamine biosynthesis.	Ornithine	28-37	ornithine decarboxylase, structural 1	Mus musculus	53-56
1903327-3	1991	The level of substrate pools of ornithine in cultured cells has been reported to markedly alter mitogen-induced ODC activity, putrescine accumulation, and DNA synthesis (V. Wu and C. V. Byus, Biochim.	Ornithine	32-41	ornithine decarboxylase, structural 1	Mus musculus	112-115
1911530-0	1991	Production of citrulline and ornithine by interferon-gamma treated macrophages.	Ornithine	29-38	interferon gamma	Mus musculus	42-58
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Ornithine	258-267	interferon gamma	Mus musculus	115-124
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Ornithine	258-267	interferon gamma	Mus musculus	97-113
1911530-7	1991	In the absence of IFN-gamma, TNF and LPS stimulate the conversion of arginine into ornithine but not citrulline.	Ornithine	83-92	tumor necrosis factor	Mus musculus	29-32
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Ornithine	258-267	interferon gamma	Mus musculus	115-124
1911530-8	1991	However, when TNF or LPS stimulated macrophages are simultaneously treated with IFN-gamma, ornithine production is relatively inhibited by the strong OAD reaction that competes with the ASE reaction for its substrate L-arginine.	Ornithine	91-100	tumor necrosis factor	Mus musculus	14-17
1911530-8	1991	However, when TNF or LPS stimulated macrophages are simultaneously treated with IFN-gamma, ornithine production is relatively inhibited by the strong OAD reaction that competes with the ASE reaction for its substrate L-arginine.	Ornithine	91-100	interferon gamma	Mus musculus	80-89
1911530-9	1991	IFN-gamma thus down-regulates the availability of ornithine and putrescine.	Ornithine	50-59	interferon gamma	Mus musculus	0-9
1899361-1	1991	The selective inhibition of murine cytotoxic T lymphocyte (CTL) differentiation in C57B1/6 (B6) anti-DBA/2 mixed leukocyte cultures (MLC) by the amino acid L-ornithine (Orn) could not be reversed by addition of up to 1000 U/ml IL-2.	Ornithine	169-172	complement component 6	Mus musculus	83-94
2017155-4	1991	In contrast, ornithine, putrescine, spermidine, and spermine, at concentrations with effects on resorption comparable to those of DFMO, inhibited the effects of calcitriol on both calcium and beta-glucuronidase release.	Ornithine	13-22	glucuronidase, beta	Mus musculus	192-210
1899361-2	1991	Analysis of the effects of Orn on induction of lymphokine-activated killer (LAK cells), using dosages of IL-2 from 10-1000 U/ml and measuring cytolytic activity against two tumor targets (P815 and YAC-1) over the course of 5 days, indicated that LAK cells were not suppressed by Orn.	Ornithine	27-30	alpha-kinase 1	Mus musculus	76-79
2085183-3	1990	The use of ornithine as a marker of biological activity of ASase is related to the fact that in the urea cycle, the specific activity of arginase is much higher than that of ASase; thus, during in vitro determinations, arginine, which is the product of ASase, is rapidly converted to ornithine.	Ornithine	11-20	adenylosuccinate lyase	Homo sapiens	59-64
1982050-1	1990	Low paradoxically low answer of growth hormone to stimulation with ornithine].	Ornithine	67-76	growth hormone 1	Homo sapiens	32-46
1959325-8	1991	Frog ODC was found to be similar to mouse enzyme in some properties, for example molecular weight, immunoreactivity and inhibition by rat antizyme, except for a slightly higher Km value for ornithine.	Ornithine	190-199	ornithine decarboxylase, structural 1	Mus musculus	5-8
2148056-8	1990	Additional experiments determined whether increased lung polyamine contents could be ascribed to elevated activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in conversion of ornithine to putrescine.	Ornithine	118-127	ornithine decarboxylase 1	Rattus norvegicus	143-146
2085183-3	1990	The use of ornithine as a marker of biological activity of ASase is related to the fact that in the urea cycle, the specific activity of arginase is much higher than that of ASase; thus, during in vitro determinations, arginine, which is the product of ASase, is rapidly converted to ornithine.	Ornithine	11-20	adenylosuccinate lyase	Homo sapiens	174-179
2085183-3	1990	The use of ornithine as a marker of biological activity of ASase is related to the fact that in the urea cycle, the specific activity of arginase is much higher than that of ASase; thus, during in vitro determinations, arginine, which is the product of ASase, is rapidly converted to ornithine.	Ornithine	11-20	adenylosuccinate lyase	Homo sapiens	174-179
2085183-3	1990	The use of ornithine as a marker of biological activity of ASase is related to the fact that in the urea cycle, the specific activity of arginase is much higher than that of ASase; thus, during in vitro determinations, arginine, which is the product of ASase, is rapidly converted to ornithine.	Ornithine	284-293	adenylosuccinate lyase	Homo sapiens	59-64
2261441-2	1990	It is shown that the cationic oligopeptides octadeca(L-lysine) (Lys18) and octadeca(L-ornithine) (Orn18) can induce a parallel duplex for the natural DNA oligomer dT10 with thymine-thymine base pairs.	Ornithine	84-95	Actin 57B	Drosophila melanogaster	163-167
1701834-9	1990	Moreover, the tetrapeptide Boc-Trp-Orn(Boc)-Asp-Phe-NH2 behaved as a partial agonist and analogues in which the Z or Boc groups on the ornithine residue were removed were full agonists.	Ornithine	135-144	brother of CDO	Cavia porcellus	27-30
1701834-9	1990	Moreover, the tetrapeptide Boc-Trp-Orn(Boc)-Asp-Phe-NH2 behaved as a partial agonist and analogues in which the Z or Boc groups on the ornithine residue were removed were full agonists.	Ornithine	135-144	brother of CDO	Cavia porcellus	39-42
1701834-9	1990	Moreover, the tetrapeptide Boc-Trp-Orn(Boc)-Asp-Phe-NH2 behaved as a partial agonist and analogues in which the Z or Boc groups on the ornithine residue were removed were full agonists.	Ornithine	135-144	brother of CDO	Cavia porcellus	39-42
2241895-2	1990	Unlike previously described ornithine decarboxylases, the enzyme activity is membrane-associated and remains in the membrane fraction after treatment with high salt, detergents or phosphatidylinositol-specific phospholipase C. Ornithine has an apparent Km value of 2.7 microM for ornithine decarboxylase.	Ornithine	227-236	Ornithine decarboxylase	Caenorhabditis elegans	28-51
2235124-7	1990	Ornithine decarboxylase activity was undetectable in the intestine of the mouse during the suckling period and was detected briefly at weaning, indicating that ornithine synthesized in the intestinal mitochondria is probably not diverted actively into the polyamine pathway and is available for synthesis of arginine by the enzymes of the urea cycle.	Ornithine	160-169	ornithine decarboxylase, structural 1	Mus musculus	0-23
2372929-6	1990	Thus, impaired mitochondrial ornithine transport seemed to cause hyperammonemia in the state of partial quantitative deficiency of OCT in this case.	Ornithine	29-38	ornithine transcarbamylase	Homo sapiens	131-134
2383423-7	1990	We conclude that in mitochondrial citrulline synthesis the rate of carbamylphosphate synthesis by CPS in the presence of NAG plays a key role in determining the rate of citrulline synthesis and ornithine dependency.	Ornithine	194-203	neuroblastoma amplified sequence	Mus musculus	121-124
2391235-0	1990	Ornithine carbamoyltransferase from Selachii: effects of the buffer system and the ornithine concentration on the pH-activity profile.	Ornithine	83-92	ornithine transcarbamylase	Homo sapiens	0-30
2372929-0	1990	Hyperammonemia caused by impaired mitochondrial ornithine transport in a patient with partial quantitative deficiency of ornithine carbamoyltransferase.	Ornithine	48-57	ornithine transcarbamylase	Homo sapiens	121-151
2293029-12	1990	The Sertoli cell, unlike any other cell, secretes putrescine, the product of ODC catalysis of ornithine.	Ornithine	94-103	ornithine decarboxylase 1	Rattus norvegicus	77-80
2317797-7	1990	Enzyme kinetic data indicated that the multiple forms of ODC can have different affinities for L-ornithine and that GTP can "normalize" the aberrant kinetic properties of these forms.	Ornithine	95-106	ornithine decarboxylase 1	Homo sapiens	57-60
34780773-1	2022	Arginase 1 (A1) is the enzyme that hydrolyzes the amino acid, L-arginine, to ornithine and urea.	Ornithine	77-86	arginase, liver	Mus musculus	0-10
2158926-8	1990	Since anaerobic arginine consumption and ornithine release are coupled in P. aeruginosa, it is proposed that arcD specifies an arginine: ornithine antiporter or a part thereof.	Ornithine	41-50	hypothetical protein	Escherichia coli	109-113
2158926-8	1990	Since anaerobic arginine consumption and ornithine release are coupled in P. aeruginosa, it is proposed that arcD specifies an arginine: ornithine antiporter or a part thereof.	Ornithine	137-146	hypothetical protein	Escherichia coli	109-113
2302717-7	1990	The 3- and 24-h ODC activities have similar apparent Kms for ornithine (34 and 50 microM, respectively), and thermal stabilities at 52 degrees C (t1/2 = 23 and 18 min, respectively), and exhibit similar half-lives in vivo (t1/2 = 15 and 18 min, respectively).	Ornithine	61-70	ornithine decarboxylase, structural 1	Mus musculus	16-19
2119573-3	1990	The arginase activity of mLIP was identified by determining the arginine degradation products, urea (by alpha-diketone-urea complex formation) and ornithine (by HPLC).	Ornithine	147-156	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	25-29
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
34662447-6	2022	RESULTS: The Pten-KO prostate increased purine nucleotide pools, cystathionine, and both reduced and oxidized glutathione (GSH, GSSG), and gluconate/glucuronate species in addition to cholesteryl sulfate and polyamine precursor ornithine.	Ornithine	228-237	phosphatase and tensin homolog	Mus musculus	13-17
34871830-5	2022	AtNATA1 was previously shown to be specific for 1,3-diaminopropane, ornithine, putrescine and thialysine, rather than Spm and spermidine.	Ornithine	68-77	Acyl-CoA N-acyltransferases (NAT) superfamily protein	Arabidopsis thaliana	0-7
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Ornithine	75-84	proline dehydrogenase 1	Homo sapiens	110-115
34943588-1	2021	Arginase-1 catalyzes the conversion of arginine to ornithine and urea.	Ornithine	51-60	arginase 1	Homo sapiens	0-10
34935905-6	2022	Given that ODC is highly expressed in the ovaries during ovulation but otherwise exhibits low activity in most tissues, we hypothesized that periovulatory supplementation of L-ornithine, the substrate of ODC, might be suitable for delivering putrescine specifically to the ovaries.	Ornithine	174-185	ornithine decarboxylase 1	Homo sapiens	204-207
34796899-4	2021	A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site.	Ornithine	190-199	ornithine decarboxylase 1	Homo sapiens	35-38
34796899-4	2021	A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site.	Ornithine	190-199	ornithine decarboxylase 1	Homo sapiens	91-94
34796899-4	2021	A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site.	Ornithine	190-199	ornithine decarboxylase 1	Homo sapiens	176-179
34943229-14	2021	The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions.	Ornithine	75-84	proline dehydrogenase 1	Homo sapiens	116-119
34703912-3	2021	Twenty-four pigs were randomly divided into 4 groups, exposed to 0, 10, 25 or 35 mg/m3 ammonia respectively for 25 d. After above 25 mg/m3 ammonia exposure, decreased aspartate (P = 0.016), glutamate (P = 0.030) and increased ornithine (P = 0.002) were found in the ammonia-removing liver, and after high ammonia (35 mg/m3) exposure, glutamine synthetase (GS) expression was increased (P = 0.012).	Ornithine	226-235	glutamate-ammonia ligase	Sus scrofa	356-358
34811637-10	2022	The relative concentrations of ornithine and argininosuccinate, which are urea cycle intermediates, were also decreased in the Ctrp3 KO liver.	Ornithine	31-40	C1q and tumor necrosis factor related protein 3	Mus musculus	127-132
34402126-6	2021	Of the 361 compounds detected in the liver, 41 compounds, including amino acids related to the Cit-arginine (Arg) cycle, argininosuccinic acid, Arg, ornithine, and Cit, as well as gamma aminobutyric acid, glycine, histidine, and nicotinamide adenine dinucleotide were abundant in l-Cit-treated livers.	Ornithine	149-158	citron rho-interacting serine/threonine kinase	Homo sapiens	282-285
34867480-1	2021	The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells (PTC) and upregulated by renal ischemia.	Ornithine	110-121	arginase type II	Mus musculus	19-35
34599427-0	2022	Arginase-1 Released into CSF After Aneurysmal Subarachnoid Hemorrhage Decreases Arginine/Ornithine Ratio: a Novel Prognostic Biomarker.	Ornithine	89-98	arginase 1	Homo sapiens	0-10
34778380-2	2021	Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeostatic conditions through the production of L-ornithine and urea.	Ornithine	168-179	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	0-3
34778380-3	2021	L-ornithine represents the intersection point between the ARG-dependent pathways and the urea cycle, therefore contributing to cell detoxification, proliferation and collagen production.	Ornithine	0-11	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	58-61
34836006-7	2021	Antagonists of G-protein-coupled receptor family C group 6 subtype A (GPRC6A) abolished the additive effect of ornithine on MSG solutions.	Ornithine	111-120	G protein-coupled receptor, family C, group 6, member A	Mus musculus	70-76
34613458-1	2021	Polyamines (putrescine, spermidine, and spermine) are synthesized primarily from ornithine via ornithine decarboxylase (ODC) in mammals.	Ornithine	81-90	ornithine decarboxylase	Gallus gallus	95-118
34613458-1	2021	Polyamines (putrescine, spermidine, and spermine) are synthesized primarily from ornithine via ornithine decarboxylase (ODC) in mammals.	Ornithine	81-90	ornithine decarboxylase	Gallus gallus	120-123
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Ornithine	215-224	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-128
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Ornithine	215-224	pyrroline-5-carboxylate reductase 1	Homo sapiens	130-133
34769188-6	2021	P5C is produced by P5C synthase (P5CS) from glutamate, and ornithine via ornithine delta-amino acid transferase (deltaOAT).	Ornithine	59-68	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-3
34769188-12	2021	This review focuses on the metabolism of P5C in the cell as an interconversion mediator of proline, glutamate, and ornithine and its role in the regulation of survival and death with particular emphasis on the metabolic context.	Ornithine	115-124	pyrroline-5-carboxylate reductase 1	Homo sapiens	41-44
34599427-9	2022	The well-known surrogate parameter for arginase acitivity, the L-arginine to L-ornithine ratio (Arg/Orn), correlated with CSF arginase-1 levels.	Ornithine	77-88	arginase 1	Homo sapiens	126-136
34560100-7	2021	We also note a correlation between the presence of ancestral ODC and ornithine/arginine auxotrophy, and link this with a known symbiotic dependence on exogenous ornithine produced by species using the arginine deiminase system.	Ornithine	69-78	ornithine decarboxylase 1	Homo sapiens	61-64
34560100-7	2021	We also note a correlation between the presence of ancestral ODC and ornithine/arginine auxotrophy, and link this with a known symbiotic dependence on exogenous ornithine produced by species using the arginine deiminase system.	Ornithine	161-170	ornithine decarboxylase 1	Homo sapiens	61-64
34278273-5	2021	Metabolomic analysis revealed that amino acid starvation induces a defect in the urea cycle, decreasing ornithine, a major intermediate, and supplementation of ornithine in an amino-acid-depleted medium fully rescued G6Pase mRNA transcription, similar to the effects of amino acid stimulation.	Ornithine	160-169	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	217-223
34559624-8	2021	The peptidoglycan type of the isolate was A4beta with an interpeptide bridge comprising l-ornithine and d-glutamic acid.	Ornithine	88-99	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	42-48
34340878-2	2021	GACR is characterised by vision decline in early life eventually leading to complete blindness, and high plasma ornithine levels.	Ornithine	112-121	ornithine aminotransferase	Homo sapiens	0-4
34326456-1	2021	Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response.	Ornithine	91-102	arginase 1	Homo sapiens	6-16
34326456-1	2021	Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response.	Ornithine	91-102	arginase 1	Homo sapiens	18-23
34281196-11	2021	A reduction of 5-oxoproline and ornithine metabolites that are involved in proline synthesis in mitochondria and affect abiotic stresses was also observed in the mfdx1-1 mutant.	Ornithine	32-41	mitochondrial ferredoxin 1	Arabidopsis thaliana	162-167
34472307-1	2021	Ornithine decarboxylase (ODC) is a key enzyme in the biosynthetic pathway of polyamines and catalyzes the decarboxylation of ornithine to produce putrescine.	Ornithine	125-134	ornithine decarboxylase 1	Homo sapiens	0-23
34472307-1	2021	Ornithine decarboxylase (ODC) is a key enzyme in the biosynthetic pathway of polyamines and catalyzes the decarboxylation of ornithine to produce putrescine.	Ornithine	125-134	ornithine decarboxylase 1	Homo sapiens	25-28
35483312-3	2022	The overexpression of the L-ornithine decarboxylase gene (the SPE1-S gene) from Saccharomyces cerevisiae in the mutant D-LCFAO-cre could make the transformant E-SPE1-S synthesize 3.6 +- 0.1 of intracellular ornithine per mg of protein and produce 10.5 g/L of putrescine.	Ornithine	26-37	ornithine decarboxylase SPE1	Saccharomyces cerevisiae S288C	161-165
35483312-3	2022	The overexpression of the L-ornithine decarboxylase gene (the SPE1-S gene) from Saccharomyces cerevisiae in the mutant D-LCFAO-cre could make the transformant E-SPE1-S synthesize 3.6 +- 0.1 of intracellular ornithine per mg of protein and produce 10.5 g/L of putrescine.	Ornithine	207-216	ornithine decarboxylase SPE1	Saccharomyces cerevisiae S288C	161-165
35608836-4	2022	Arginine decarboxylase activity was decreased in roots, suggesting that the ornithine decarboxylase-dependent production of putrescine was important in situations of ammonium stress.	Ornithine	76-85	arginine decarboxylase	Medicago truncatula	0-22
35460691-2	2022	Over the past decade, human ornithine aminotransferase (hOAT), which is an enzyme that catalyzes the metabolic conversion of ornithine into an intermediate for proline or glutamate synthesis, has been found to be overexpressed in HCC cells.	Ornithine	125-134	ornithine aminotransferase	Homo sapiens	28-54
35543513-6	2022	In addition, we newly identified two mutations in the ARG5,6 gene encoding the Cys119Tyr or Val267Ala variant of NAGK of sake yeast mutants with intracellular ornithine accumulation.	Ornithine	159-168	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	54-60
35543513-11	2022	In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK) encoded by the ARG5,6 gene catalyzes the second step in ornithine and arginine biosynthesis, and its activity is subjected to feedback inhibition by arginine.	Ornithine	128-137	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	87-93
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	98-109	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	98-109	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	98-109	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	111-114	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	111-114	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Ornithine	111-114	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35308356-11	2022	The purified Odc1 protein decarboxylated lysine into cadaverine, while the recombinant Odc2 protein preferentially produced putrescine from ornithine but also exhibited low lysine decarboxylating activity.	Ornithine	140-149	ornithine decarboxylase pseudogene	Homo sapiens	87-91
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Ornithine	112-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	24-63
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Ornithine	112-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-69
35306816-4	2022	Through the combination of the electrochemical and HRMS results, decreases in arginine and NO and increases in ADMA and ornithine were observed after modulation by CK, and two highly correlated metabolic pathways including arginine and proline metabolism and vascular smooth muscle contraction were found.	Ornithine	120-129	cytidine/uridine monophosphate kinase 1	Homo sapiens	164-166
35242829-10	2022	Furthermore, inhibition of ornithine metabolism by silencing ornithine decarboxylase (ODC) in DMSCs partly abolished the benefits of DMSC transplantation.	Ornithine	27-36	ornithine decarboxylase 1	Homo sapiens	61-84
35177109-6	2022	Vessel permeability and the gene expression of the primary transporter of L-ornithine, cationic amino acid transporter-1 (Cat-1) in the brain cortex, pancreas, liver and lung were determined.	Ornithine	74-85	solute carrier family 7 member 1	Rattus norvegicus	87-120
35177109-6	2022	Vessel permeability and the gene expression of the primary transporter of L-ornithine, cationic amino acid transporter-1 (Cat-1) in the brain cortex, pancreas, liver and lung were determined.	Ornithine	74-85	solute carrier family 7 member 1	Rattus norvegicus	122-127
35177109-12	2022	RESULTS: In the L-ornithine-induced AP model vessel permeability for fluorescein and Cat-1 expression levels were elevated in the brain cortex and pancreas.	Ornithine	16-27	solute carrier family 7 member 1	Rattus norvegicus	85-90
35242829-11	2022	Conclusion: Compared with BMSCs, DMSCs exhibited better efficacy in improving revascularization and heart remodeling post-MI via the activation of ODC-associated ornithine metabolism.	Ornithine	162-171	ornithine decarboxylase 1	Rattus norvegicus	147-150
35242829-10	2022	Furthermore, inhibition of ornithine metabolism by silencing ornithine decarboxylase (ODC) in DMSCs partly abolished the benefits of DMSC transplantation.	Ornithine	27-36	ornithine decarboxylase 1	Rattus norvegicus	86-89
35054098-5	2022	In addition, the ratio putrescine/ornithine, representing the activity of ornithine decarboxylase, was significantly increased in patients with active compared to inactive orbitopathy (p = 0.0011, fold change 3.75).	Ornithine	34-43	ornithine decarboxylase 1	Homo sapiens	74-97
35208720-5	2022	Our results show that l-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB.	Ornithine	22-33	chemotactic transducer PctA	Pseudomonas aeruginosa PAO1	192-196
35208720-5	2022	Our results show that l-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB.	Ornithine	22-33	chemotactic transducer PctB	Pseudomonas aeruginosa PAO1	201-205
35018637-5	2022	GABA and ornithine were produced during fermentation, indicating glutamate decarboxylase and arginine deiminase activities.	Ornithine	9-18	glutamate decarboxylase	Cucumis sativus	65-88
2629821-1	1989	The behavior of two enzymes of the ornithine pathway, leading to the formation of proline and, eventually, of collagen, arginase and ornithine oxo-acid aminotransferase has been investigated in normal and inflamed gingival tissue.	Ornithine	35-44	ornithine aminotransferase	Homo sapiens	133-168
35281666-1	2022	Arginase deficiency is a rare autosomal recessive urea cycle disorder (UCD) caused by mutations in the ARG1 gene encoding arginase that catalyses the hydrolysis of arginine to ornithine and urea.	Ornithine	176-185	arginase 1	Homo sapiens	103-107
2584228-1	1989	Ornithine-delta-aminotransferase (OAT) is a nuclear-encoded, mitochondrial enzyme that converts ornithine to glutamate semialdehyde.	Ornithine	96-105	ornithine aminotransferase	Rattus norvegicus	0-32
2584228-1	1989	Ornithine-delta-aminotransferase (OAT) is a nuclear-encoded, mitochondrial enzyme that converts ornithine to glutamate semialdehyde.	Ornithine	96-105	ornithine aminotransferase	Rattus norvegicus	34-37
2796972-1	1989	Production of polyamines such as putrescine (PUT), spermidine (SPD) and spermine (SPM) primarily from ornithine by ornithine decarboxylase (ODC) is correlated with cell proliferation.	Ornithine	102-111	ornithine decarboxylase 1	Homo sapiens	115-138
2554065-1	1989	Ornithine decarboxylase (ODC) catalyzes the formation of putrescine from ornithine, which is the first step in the pathway of mammalian polyamine biosynthesis.	Ornithine	73-82	ornithine decarboxylase 1	Homo sapiens	0-23
2554065-1	1989	Ornithine decarboxylase (ODC) catalyzes the formation of putrescine from ornithine, which is the first step in the pathway of mammalian polyamine biosynthesis.	Ornithine	73-82	ornithine decarboxylase 1	Homo sapiens	25-28
2504287-2	1989	L-Arginine and L-ornithine stimulate insulin release from pancreatic islets exposed to D-glucose.	Ornithine	15-26	insulin	Homo sapiens	37-44
2753136-1	1989	Ornithine induced more than 36-fold the ornithine decarboxylase activity in confined Ehrlich ascites tumour cells after 3.5 h of continuous perifusion with 0.5 mM ornithine; arginine and glutamine also induced the activity 3- and 4-fold, respectively.	Ornithine	0-9	ornithine decarboxylase, structural 1	Mus musculus	40-63
2796972-1	1989	Production of polyamines such as putrescine (PUT), spermidine (SPD) and spermine (SPM) primarily from ornithine by ornithine decarboxylase (ODC) is correlated with cell proliferation.	Ornithine	102-111	ornithine decarboxylase 1	Homo sapiens	140-143
2918520-4	1989	Just as 1 was a good substrate for FPGS, the ornithine analogue 2 proved to be among the more potent competitive inhibitors of this enzyme discovered to date, with a Ki,s of 10 microM.	Ornithine	45-54	folylpolyglutamyl synthetase	Mus musculus	35-39
2929364-2	1989	Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine.	Ornithine	86-95	ornithine decarboxylase 1	Rattus norvegicus	0-23
2452253-6	1988	Interestingly, when the amine function in the side chain of the ornithine-31 was protected by a benzyloxycarbonyl group, an unusual high affinity for pancreatic binding sites was observed and the related analogue proved to be a new peripheral CCK antagonist.	Ornithine	64-73	cholecystokinin	Cavia porcellus	243-246
2722995-4	1989	The developed method was applied to the determination of putrescine formed from ornithine by ornithine decarboxylase.	Ornithine	80-89	ornithine decarboxylase 1	Homo sapiens	93-116
2563942-4	1989	Phosphate efflux caused by externally added ornithine was shown both as revealed by a c colorimetric assay and as continuously monitored by measuring extramitochondrial reduction of NAD+ in the presence of glyceraldehyde-3-phosphate, glyceraldehyde-3-phosphate dehydrogenase, ADP and 3-phosphoglycerate kinase.	Ornithine	44-53	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	234-274
2501116-2	1989	Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations.	Ornithine	18-27	ornithine aminotransferase	Homo sapiens	56-59
2501116-2	1989	Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations.	Ornithine	18-27	ornithine aminotransferase	Homo sapiens	124-127
2501116-2	1989	Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations.	Ornithine	92-95	ornithine aminotransferase	Homo sapiens	16-54
2501116-2	1989	Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations.	Ornithine	92-95	ornithine aminotransferase	Homo sapiens	56-59
2501116-2	1989	Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations.	Ornithine	92-95	ornithine aminotransferase	Homo sapiens	124-127
3141077-5	1988	Enzyme kinetic analyses indicated that GTP lowered the atypically high apparent Km values for L-ornithine of the papilloma enzyme to values typical of epidermal ODC.	Ornithine	94-105	ornithine decarboxylase, structural 1	Mus musculus	161-164
3190739-8	1988	Together with earlier studies, these data indicate that the potency of FPGS inhibition by an analog containing ornithine closely parallels the relative substrate activity of its glutamate-containing counterpart.	Ornithine	111-120	folylpolyglutamate synthase	Homo sapiens	71-75
3420115-8	1988	It was concluded that AIB could partially overcome the ornithine-induced inhibition of ODC activity.	Ornithine	55-64	ornithine decarboxylase 1	Homo sapiens	87-90
3136663-3	1988	Renal concentration of putrescine, the product of ODC"s decarboxylation of ornithine, was increased 3, 8, and 48 h after UN, but concentrations of polyamines synthesized later in the pathway, spermidine and spermine, were not appreciably affected.	Ornithine	75-84	ornithine decarboxylase 1	Rattus norvegicus	50-53
2838550-1	1988	Human rTNF-alpha stimulates the metabolism of murine peritoneal macrophages as demonstrated by an increased consumption of arginine and an increased release of L-ornithine.	Ornithine	160-171	tumor necrosis factor	Rattus norvegicus	6-16
2707281-4	1989	In this patient the substitution thus aimed at increasing the intramitochondrial ornithine in order to reach a critical substrate concentration for the kinetically abnormal OTC.	Ornithine	81-90	ornithine transcarbamylase	Homo sapiens	173-176
2591638-2	1989	The Km for ammonia of carbamyl phosphate synthetase was determined by preincubating isolated liver cells for 30 min in the absence of ammonia and bicarbonate and in the presence of ornithine, chloroquine, which blocks lysosomal proteolysis, and aminoxy acetic acid, which inhibits transaminases.	Ornithine	181-190	carbamoyl-phosphate synthase 1	Rattus norvegicus	22-51
3216774-0	1988	Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures.	Ornithine	10-19	transferrin	Rattus norvegicus	23-34
3216774-4	1988	Thus, it may be postulated that the mechanism involved in the increased transferrin secretion by L-ornithine is of pretranslational origin.	Ornithine	97-108	transferrin	Homo sapiens	72-83
3190739-0	1988	Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs.	Ornithine	79-88	folylpolyglutamate synthase	Homo sapiens	46-75
3146234-2	1988	True ODC activity was determined by two methods: (a) addition of the inhibitors alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ODC, or aminooxyacetate (AOA), an inhibitor that blocks the decarboxylation of ornithine by mitochondrial enzymes; and (b) chromatographic analysis of the reaction products.	Ornithine	100-109	ornithine decarboxylase 1	Rattus norvegicus	5-8
3146234-7	1988	With AOA, the ODC activities of the fresh and frozen supernatants were similar, indicating that the large increase in apparent ODC activity in frozen tissue was due to artifacts from the metabolism of ornithine via the mitochondrial pathway.	Ornithine	201-210	ornithine decarboxylase 1	Rattus norvegicus	127-130
3258250-1	1988	The Km for ornithine is remarkably constant during the course of postnatal development in both normal and spf mutant mice even if a large but transient increase in ornithine decarboxylase (ODC) activity is noted.	Ornithine	11-20	ornithine decarboxylase, structural 1	Mus musculus	189-192
3383999-3	1988	Analogues of AVP and oxytocin (OT), modified at positions 1 (2-hydroxy-3-mercaptopropionic acid, deamino-3-mercaptopropionic acid), 2 (Phe), 4 (Arg, Val), 7 (Sar) or 8 (Orn) were synthesized and tested for uterotonic activity on human and rat uterine strips, and for vasopressor and antidiuretic activity in the rat in vivo.	Ornithine	169-172	arginine vasopressin	Homo sapiens	13-16
3338115-7	1988	Pretreatment of mice with TPA 12 h or 96 h before the second TPA application resulted in the reduction or the increase in the Vmax values of ODC both for ornithine and pyridoxal-5"-phosphate, respectively.	Ornithine	154-163	ornithine decarboxylase, structural 1	Mus musculus	141-144
3342404-5	1988	Kinetic analyses indicated that GTP either lowered the apparent Km of tumor ODC for L-ornithine, increased the Vmax, or had both effects, depending on the tumor examined.	Ornithine	84-95	ornithine decarboxylase 1	Homo sapiens	76-79
2897088-3	1988	The objective of the present study was to compare the effects of elevation of GABA concentration and those of inactivation of L-ornithine: 2-oxoacid aminotransferase (OAT) on the in vivo metabolism of L-ornithine (Orn) in brain.	Ornithine	126-137	ornithine aminotransferase	Mus musculus	167-170
3147916-5	1988	The results presented here provide additional in vitro evidence on the characteristic changes in the metabolic imbalance of ornithine in tumor cells induced by DFMO via inhibition of ornithine decarboxylase and ornithine carbamoyl transferase activities.	Ornithine	124-133	ornithine decarboxylase, structural 1	Mus musculus	183-206
3145970-4	1988	Inhibition is specific, as a number of substrates and end products of ODC and ADC activities antagonize DFMA and DFMO (i.e. ornithine greater than putrescine = spermidine greater than agmatine).	Ornithine	124-133	ornithine decarboxylase 1	Homo sapiens	70-73
2897088-3	1988	The objective of the present study was to compare the effects of elevation of GABA concentration and those of inactivation of L-ornithine: 2-oxoacid aminotransferase (OAT) on the in vivo metabolism of L-ornithine (Orn) in brain.	Ornithine	214-217	ornithine aminotransferase	Mus musculus	167-170
2897088-3	1988	The objective of the present study was to compare the effects of elevation of GABA concentration and those of inactivation of L-ornithine: 2-oxoacid aminotransferase (OAT) on the in vivo metabolism of L-ornithine (Orn) in brain.	Ornithine	201-212	ornithine aminotransferase	Mus musculus	167-170
3312423-6	1987	The amino acid composition of the purified HSP included 30% glycine, 15% serine, 12% glutamic acid, and 4% ornithine, but only 2.3% histidine.	Ornithine	107-116	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
3125950-2	1987	Subcellular fractionation showed the enzyme associated with the post-mitochondrial supernatant fraction in each of the tissues: Specific activities of ODC, defined as alpha-difluoromethylornithine (DFMO)-sensitive decarboxylation of ornithine, in the supernatant fractions of combined inner ear tissues were: guinea pig = 44 +/- 4 pmoles CO2 produced/hour/mg protein, and rat = 133 +/- 30.	Ornithine	187-196	ornithine decarboxylase 1	Homo sapiens	151-154
3586712-0	1987	Tumor necrosis factor augments the immunogenicity and the production of L-ornithine by peritoneal macrophages.	Ornithine	72-83	tumor necrosis factor	Homo sapiens	0-21
3623846-6	1987	Our findings suggested that OAT plays an important role in ornithine metabolism in these ocular tissues.	Ornithine	59-68	ornithine aminotransferase	Rattus norvegicus	28-31
3595616-0	1987	L-ornithine-induced inactivation of mammalian ornithine decarboxylase in vitro.	Ornithine	0-11	ornithine decarboxylase 1	Homo sapiens	46-69
3295876-7	1987	Presence of OTCase enzymatic activity in an arg3 strain expressing wild-type precursor was utilized to obtain selective growth in a medium devoid of arginine but supplemented with the OTCase substrate ornithine.	Ornithine	201-210	ornithine transcarbamylase	Homo sapiens	12-18
3295876-7	1987	Presence of OTCase enzymatic activity in an arg3 strain expressing wild-type precursor was utilized to obtain selective growth in a medium devoid of arginine but supplemented with the OTCase substrate ornithine.	Ornithine	201-210	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	44-48
3295876-7	1987	Presence of OTCase enzymatic activity in an arg3 strain expressing wild-type precursor was utilized to obtain selective growth in a medium devoid of arginine but supplemented with the OTCase substrate ornithine.	Ornithine	201-210	ornithine transcarbamylase	Homo sapiens	184-190
3586712-2	1987	TNF was found to augment the capacity of peritoneal macrophages to convert 14C-labeled arginine into L-ornithine and to release L-ornithine into the culture medium.	Ornithine	101-112	tumor necrosis factor	Homo sapiens	0-3
3110288-12	1987	Elicited or resident PM which have been incubated for several days in culture release practically no ornithine; but ornithine production can be induced again by incubation for 24 hr with LPS and to some extent also with interferon-gamma.	Ornithine	116-125	interferon gamma	Mus musculus	220-236
3586712-1	1987	The release of ornithine by macrophages and its correlation with their immunogenicity after treatment with recombinant human tumor necrosis factor-alpha (TNF) were analyzed.	Ornithine	15-24	tumor necrosis factor	Homo sapiens	125-152
3586712-1	1987	The release of ornithine by macrophages and its correlation with their immunogenicity after treatment with recombinant human tumor necrosis factor-alpha (TNF) were analyzed.	Ornithine	15-24	tumor necrosis factor	Homo sapiens	154-157
3586712-2	1987	TNF was found to augment the capacity of peritoneal macrophages to convert 14C-labeled arginine into L-ornithine and to release L-ornithine into the culture medium.	Ornithine	128-139	tumor necrosis factor	Homo sapiens	0-3
3586712-3	1987	In agreement with the previous observation that L-ornithine potentiates immune responses in vivo, it was also found that treatment of peritoneal exudate cells with TNF augments the capacity of these cells to immunize mice in vivo for a subsequent secondary in vitro cytotoxic response against non-major-histocompatibility antigens.	Ornithine	48-59	tumor necrosis factor	Mus musculus	164-167
3816789-3	1987	Urea synthesis by the perfused rat liver supplemented with lactate (5 mM), ornithine (2 mM) and methionine sulfoximine (0.15 mM), an inhibitor of glutamine synthetase, was stimulated by stepwise infusion of NH4Cl at doses ranging from 0.24 mM to 3.0 mM.	Ornithine	75-84	glutamate-ammonia ligase	Rattus norvegicus	146-166
3583682-4	1987	A second isozyme, designated AII (or A4), has a neutral pI, is located in the mitochondrial matrix, and is thought to be involved primarily in the production of ornithine as a precursor of proline and glutamate.	Ornithine	161-170	NLR family pyrin domain containing 3	Homo sapiens	29-32
3098738-0	1987	Channeling of extramitochondrial ornithine to matrix ornithine transcarbamylase.	Ornithine	33-42	ornithine transcarbamylase	Homo sapiens	53-79
3098738-2	1987	External ornithine is channeled between its transporter and ornithine transcarbamylase; mitochondria preloaded with cold ornithine, then incubated with [3H]ornithine, produced citrulline of the same specific radioactivity as that of external ornithine, while matrix ornithine remained essentially unlabeled.	Ornithine	9-18	ornithine transcarbamylase	Homo sapiens	60-86
3107993-5	1987	The increased homocitrulline excretion suggests that ornithine conversion to citrulline via ornithine transcarbamylase (OTC) was inhibited.	Ornithine	53-62	ornithine transcarbamylase	Homo sapiens	92-118
3107993-5	1987	The increased homocitrulline excretion suggests that ornithine conversion to citrulline via ornithine transcarbamylase (OTC) was inhibited.	Ornithine	53-62	ornithine transcarbamylase	Homo sapiens	120-123
3107993-7	1987	In addition to the direct ammoniagenic property of lysine, impaired ornithine conversion to citrulline resulting from the inhibition of both OTC activity and mitochondrial ornithine uptake by lysine may be responsible for the increase in blood ammonia and urinary orotic acid.	Ornithine	68-77	ornithine transcarbamylase	Homo sapiens	141-144
3467314-5	1986	Kinetic analyses indicated that the papilloma OrnDCase has an altered affinity for its substrate, L-ornithine, compared to epidermal OrnDCase.	Ornithine	98-109	ornithine decarboxylase, structural 1	Mus musculus	46-54
2427106-4	1986	An additional 33 kHz, eta = 0 component arising from deuterons on mobile ornithine side chains was present in gramicidin S. In the gel phase of dipalmitoylphosphatidylcholine liposomes the gramicidins gave spectra that had components identical with those obtained from the solids.	Ornithine	73-82	endothelin receptor type A	Homo sapiens	22-25
2944613-11	1986	Generation of CTLe from the MLC plus ornithine population was radiation sensitive and could be inhibited by reexposure to ornithine, even in the presence of IL-2.	Ornithine	37-46	interleukin 2	Homo sapiens	157-161
24232152-4	1986	The enzyme activities of the route ornithine to methylpyrroline, which are those of ornithine decarboxylase, putrescine methyltransferase and methylputrescine oxidase, were determined during callus growth in the induction medium and as a control under non-nicotine-stimulating conditions (growth medium).	Ornithine	35-44	ornithine decarboxylase	Nicotiana tabacum	84-107
24232152-4	1986	The enzyme activities of the route ornithine to methylpyrroline, which are those of ornithine decarboxylase, putrescine methyltransferase and methylputrescine oxidase, were determined during callus growth in the induction medium and as a control under non-nicotine-stimulating conditions (growth medium).	Ornithine	35-44	copper methylamine oxidase-like	Nicotiana tabacum	142-166
2871896-5	1986	This major inhibition was completely reversed in the presence of 0.5 mM putrescine, the product of ODC-mediated catabolism of ornithine.	Ornithine	126-135	ornithine decarboxylase 1	Homo sapiens	99-102
3095024-6	1986	Intrauterine administration of several concentrations of a new synthetic L-ornithine analogue, AIAVA (2-amine-5-iodoacetamide valeric acid), produced embryonic growth arrest concomitant with arginase inhibition but not ornithine decarboxylase.	Ornithine	73-84	ornithine decarboxylase 1	Rattus norvegicus	219-242
3930296-0	1985	Equilibrium between active and inactive forms of rat liver ornithine decarboxylase mediated by L-ornithine and salts.	Ornithine	95-106	ornithine decarboxylase 1	Rattus norvegicus	59-82
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Ornithine	413-422	arginine decarboxylase	Nicotiana tabacum	62-65
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Ornithine	413-422	arginine decarboxylase	Nicotiana tabacum	159-162
3931086-2	1985	At concentrations of 0.5 mM and above alpha-difluoromethyl ornithine (DFMO), which inhibits ornithine decarboxylase and the conversion of ornithine to putrescine, significantly attenuated the mitogenic effect of prolactin.	Ornithine	59-68	ornithine decarboxylase 1	Homo sapiens	92-115
3931086-2	1985	At concentrations of 0.5 mM and above alpha-difluoromethyl ornithine (DFMO), which inhibits ornithine decarboxylase and the conversion of ornithine to putrescine, significantly attenuated the mitogenic effect of prolactin.	Ornithine	59-68	prolactin	Homo sapiens	212-221
3958058-6	1986	Intracellular putrescine and spermidine levels are substantially decreased when cultures are maintained in medium supplemented with insulin, transferrin, and ferrous sulfate, rather than serum, which is the sole source of exogenous ornithine.	Ornithine	232-241	insulin	Cricetulus griseus	132-139
3953797-3	1986	Since OTC catalyzes the conversion of ornithine to citrulline, in the presence of carbamoyl-phosphate, the effect of a disturbed ornithine metabolism on the postnatal development of the small intestine has been evaluated.	Ornithine	38-47	ornithine transcarbamylase	Mus musculus	6-9
3953797-3	1986	Since OTC catalyzes the conversion of ornithine to citrulline, in the presence of carbamoyl-phosphate, the effect of a disturbed ornithine metabolism on the postnatal development of the small intestine has been evaluated.	Ornithine	129-138	ornithine transcarbamylase	Mus musculus	6-9
4032436-3	1985	Phosphonic (4a,b) and phosphinic (5a-d) analogues of ornithine were synthesized and evaluated for their inhibitory activity against ornithine decarboxylase and against the lymphocytic leukemia P388.	Ornithine	53-62	ornithine decarboxylase 1	Rattus norvegicus	132-155
3923020-1	1985	GH-releasing factor (GHRH) was measured by RIA in the plasma of 22 constitutionally short children given an ornithine infusion or an oral dose of L-dopa.	Ornithine	108-117	growth hormone releasing hormone	Homo sapiens	21-25
3923020-7	1985	On the contrary, ornithine-induced GH release was not preceded by a GHRH rise, but was followed by a GHRH decrease, from 51 to 27 pg/ml (P less than 0.02).	Ornithine	17-26	growth hormone releasing hormone	Homo sapiens	101-105
3159341-1	1985	Ornithine transcarbamylase catalyzes the synthesis of citrulline from carbamyl phosphate and ornithine.	Ornithine	93-102	ornithine transcarbamylase	Rattus norvegicus	0-26
3158402-7	1985	The addition of interleukin 2 (IL-2)-containing EL-4 supernatants did not prevent but rather enhanced the suppressive effect of L-ornithine.	Ornithine	128-139	interleukin 2	Homo sapiens	16-29
3993779-5	1985	Ornithine prevented the increase in both normal and hepatectomized rats, suggesting that ornithine was rate limiting for the ornithine carbamoyltransferase (OCT) reaction.	Ornithine	0-9	ornithine transcarbamylase	Rattus norvegicus	125-155
3993779-5	1985	Ornithine prevented the increase in both normal and hepatectomized rats, suggesting that ornithine was rate limiting for the ornithine carbamoyltransferase (OCT) reaction.	Ornithine	0-9	ornithine transcarbamylase	Rattus norvegicus	157-160
3993779-5	1985	Ornithine prevented the increase in both normal and hepatectomized rats, suggesting that ornithine was rate limiting for the ornithine carbamoyltransferase (OCT) reaction.	Ornithine	89-98	ornithine transcarbamylase	Rattus norvegicus	125-155
3993779-5	1985	Ornithine prevented the increase in both normal and hepatectomized rats, suggesting that ornithine was rate limiting for the ornithine carbamoyltransferase (OCT) reaction.	Ornithine	89-98	ornithine transcarbamylase	Rattus norvegicus	157-160
3993779-6	1985	The orotic acid excretion response to NH4+ was much less 24-27 h post-Hx, indicating that ornithine availability for the OCT reaction may be increased at this time.	Ornithine	90-99	ornithine transcarbamylase	Rattus norvegicus	121-124
3158402-7	1985	The addition of interleukin 2 (IL-2)-containing EL-4 supernatants did not prevent but rather enhanced the suppressive effect of L-ornithine.	Ornithine	128-139	interleukin 2	Homo sapiens	31-35
3923277-1	1985	Incubation of murine spleen and bone marrow cells with homogeneously purified interleukin 3 (IL-3) results in increased urea and ornithine production.	Ornithine	129-138	interleukin 3	Mus musculus	78-97
3920317-8	1985	By the criteria tested, the immunosuppressive effect of L-ornithine is more selective than that of cyclosporine A, which was previously found to suppress not only the activation of cytotoxic activity but also proliferative responses and the production of the lymphokines IL 2 and IFN-gamma.	Ornithine	56-67	interleukin 2	Homo sapiens	271-275
3920317-8	1985	By the criteria tested, the immunosuppressive effect of L-ornithine is more selective than that of cyclosporine A, which was previously found to suppress not only the activation of cytotoxic activity but also proliferative responses and the production of the lymphokines IL 2 and IFN-gamma.	Ornithine	56-67	interferon gamma	Homo sapiens	280-289
6389319-4	1984	Putrescine (the product formed from ornithine by ODC), at 10(-5) M, markedly inhibited the induction of ODC by insulin or FBS, but the inhibition was less when asparagine was present.	Ornithine	36-45	ornithine decarboxylase 1	Rattus norvegicus	49-52
2933755-2	1985	NuS is used clinically to improve a negative nitrogen balance, while the amino acid composition of NuC has a beneficial effect on the ornithine cycle and thus helps to normalize the NH3 level in patients with liver failure.	Ornithine	134-143	nucleobindin 1	Homo sapiens	99-102
16663852-6	1984	On inhibiting glutamine synthetase using MSX, (15)N enrichment of glutamate, alanine, aspartate, and ornithine continued although labeling of glutamine was quite low.	Ornithine	101-110	glutamate-ammonia ligase	Homo sapiens	14-34
6381100-4	1984	Selective inactivation of the two types of ODC by the (R)-enantiomer is in agreement with the stereochemistry reported for ornithine decarboxylation by the enzyme.	Ornithine	123-132	ornithine decarboxylase 1	Homo sapiens	43-46
6389319-4	1984	Putrescine (the product formed from ornithine by ODC), at 10(-5) M, markedly inhibited the induction of ODC by insulin or FBS, but the inhibition was less when asparagine was present.	Ornithine	36-45	ornithine decarboxylase 1	Rattus norvegicus	104-107
6539129-0	1984	A role for ornithine in the regulation of putrescine accumulation and ornithine decarboxylase activity in Reuber H35 hepatoma cells.	Ornithine	11-20	ornithine decarboxylase 1	Rattus norvegicus	70-93
6092398-3	1984	"77orn", a derivative of the Morris rat hepatoma 7777, stably expresses high levels of ornithine transcarbamoylase (OTC) and carbamoylphosphate synthetase I (CPS-I), and is able to grow indefinitely in ornithine-medium (medium with ornithine in place of arginine).	Ornithine	87-96	ornithine transcarbamylase	Rattus norvegicus	116-119
6430547-1	1984	We have investigated the effect of age, a high-fat diet, sodium deoxycholate, and the ornithine analogue alpha-difluoromethylornithine on ornithine decarboxylase (ODC) activity in the rat colon.	Ornithine	86-95	ornithine decarboxylase 1	Rattus norvegicus	138-161
6430547-1	1984	We have investigated the effect of age, a high-fat diet, sodium deoxycholate, and the ornithine analogue alpha-difluoromethylornithine on ornithine decarboxylase (ODC) activity in the rat colon.	Ornithine	86-95	ornithine decarboxylase 1	Rattus norvegicus	163-166
6379395-3	1984	The virally activated ornithine decarboxylase removes ornithine from participation in the urea cycle by metabolizing ornithine to putrescine which, in turn, is metabolized to spermidine.	Ornithine	54-63	ornithine decarboxylase 1	Homo sapiens	22-45
6539129-1	1984	We investigated the ability of intracellular ornithine to alter both the biosynthesis of putrescine and the activity of ornithine decarboxylase in Reuber H35 hepatoma cells in culture incubated with 12-O- tetrade - canoylphorbol 13-acetate (TPA).	Ornithine	45-54	ornithine decarboxylase 1	Rattus norvegicus	120-143
6706914-1	1984	To determine the steric course of the reaction of bacterial ornithine decarboxylase [EC 4.1.1.17], we have carried out the decarboxylation of L-ornithine in 2H2O and that of DL-[2-2H]ornithine in H2O, and obtained putrescine bearing a single deuterium atom in the C-1 position.	Ornithine	142-153	ornithine decarboxylase 1	Homo sapiens	60-83
6198722-4	1984	Ornithine was present in hydrolyzates of 21.5K MBP, but it was not detected in any of the peptides.	Ornithine	0-9	myelin basic protein	Ovis aries	47-50
6190408-10	1983	Levels of liver urea and ornithine were found to vary in inverse proportion with the magnitude of ODC stimulation.	Ornithine	25-34	ornithine decarboxylase 1	Rattus norvegicus	98-101
6631913-1	1983	(E)-Dehydro analogues of alpha-(fluoromethyl)putrescine and -ornithine derivatives were synthesized and evaluated in vitro as irreversible inhibitors of a preparation of ornithine decarboxylase (ODC, EC 4.1.1.17) obtained from rat liver.	Ornithine	61-70	ornithine decarboxylase 1	Rattus norvegicus	170-193
6631913-1	1983	(E)-Dehydro analogues of alpha-(fluoromethyl)putrescine and -ornithine derivatives were synthesized and evaluated in vitro as irreversible inhibitors of a preparation of ornithine decarboxylase (ODC, EC 4.1.1.17) obtained from rat liver.	Ornithine	61-70	ornithine decarboxylase 1	Rattus norvegicus	195-198
6854188-5	1983	This study, which indicates a differential effect of ornithine on PL and GH secretion in the mother and fetus, suggests that the factors regulating PL and GH secretion in the mother and fetus are distinct.	Ornithine	53-62	chorionic somatomammotropin hormone	Ovis aries	66-68
6414762-1	1983	Decarboxylation of L-ornithine by L-ornithine decarboxylase (ODC; E.C.4.1.1.17.)	Ornithine	19-30	ornithine decarboxylase 1	Homo sapiens	34-59
6414762-1	1983	Decarboxylation of L-ornithine by L-ornithine decarboxylase (ODC; E.C.4.1.1.17.)	Ornithine	19-30	ornithine decarboxylase 1	Homo sapiens	61-64
6854188-5	1983	This study, which indicates a differential effect of ornithine on PL and GH secretion in the mother and fetus, suggests that the factors regulating PL and GH secretion in the mother and fetus are distinct.	Ornithine	53-62	chorionic somatomammotropin hormone	Ovis aries	148-150
6187826-1	1983	The production of urea and ornithine is increased greatly in spleen cell cultures of an allograft recipient in the presence of donor cells (secondary MLC) in comparison to that of primary MLC (without previous allograft).	Ornithine	27-36	modulator of VRAC current 1	Homo sapiens	150-153
6187826-5	1983	The increased production of urea and ornithine during MLC results from the action of a lymphokine released by recipient cells in the presence of donor cells.	Ornithine	37-46	modulator of VRAC current 1	Homo sapiens	54-57
7304077-15	1981	Insulin-induced hypoglycaemia, arginine and ornithine administration resulted in inconsistent and sluggish GH increment.	Ornithine	44-53	somatotropin	Canis lupus familiaris	107-109
6830854-1	1983	Ornithine was found to be toxic to cells that lack ornithine aminotransferase (EC 2.6.1.13).	Ornithine	0-9	ornithine aminotransferase, mitochondrial	Cricetulus griseus	51-77
6312977-3	1983	These differences were provoked by an additional effect of the precursors of syntheses studied, i.e. lactate or ornithine, on the hydrogen supply of the respiratory chain, as was reflected in terms of the reduction degree of cytochrome c in isolated mitochondria.	Ornithine	112-121	cytochrome c, somatic	Homo sapiens	225-237
7085611-6	1982	The stimulation by ornithine of mitochondrial carbamyl phosphate synthesis was prevented when ornithine transcarbamylase was inhibited more than 96% by 5 mM delta-N-phosphonacetyl-L-ornithine, suggesting that the normal stimulatory effect of ornithine on carbamyl phosphate synthetase occurs via ornithine transcarbamylase.	Ornithine	19-28	ornithine transcarbamylase	Rattus norvegicus	94-120
7085611-6	1982	The stimulation by ornithine of mitochondrial carbamyl phosphate synthesis was prevented when ornithine transcarbamylase was inhibited more than 96% by 5 mM delta-N-phosphonacetyl-L-ornithine, suggesting that the normal stimulatory effect of ornithine on carbamyl phosphate synthetase occurs via ornithine transcarbamylase.	Ornithine	19-28	ornithine transcarbamylase	Rattus norvegicus	296-322
7087958-3	1982	The kinetic parameters of the urea cycle enzymes are the same in fetal liver as in adult liver, except that the Km values of ornithine carbamoyltransferase for L-ornithine are 3.5 mM and 0.42 mM in the fetus and in adult liver, respectively.	Ornithine	160-171	ornithine transcarbamylase	Homo sapiens	125-155
16662144-1	1982	In excised pro(1-1) mutant and corresponding normal type roots of Zea mays L. the uptake and interconversion of [(14)C]proline, [(14)C]glutamic acid, [(14)C]glutamine, and [(14)C]ornithine and their utilization for protein synthesis was measured with the intention of finding an explanation for the proline requirement of the mutant.	Ornithine	179-188	profilin-1	Zea mays	11-18
6833225-1	1983	The mechanism of inhibition of pyruvate carboxylase, pyruvate dehydrogenase, and carbamyl phosphate synthetase induced by alpha-ketoisovalerate metabolism has been investigated in isolated rat hepatocytes incubated with lactate, pyruvate, ammonia, and ornithine as substrates.	Ornithine	252-261	pyruvate carboxylase	Rattus norvegicus	31-51
6422152-4	1983	The ornithine concentration in the blood cells of the patients reached a peak 2 h after the oral administration, and remained high for at least 4 h, although after 2 h the concentration curves differed in the three types of cells.	Ornithine	4-13	PEAK1 related, kinase-activating pseudokinase 1	Homo sapiens	73-79
7141003-3	1982	Phosphorylation of OrnDCase inhibits its capacity to catalyze decarboxylation of ornithine.	Ornithine	81-90	ornithine decarboxylase 1	Rattus norvegicus	19-27
7173402-0	1982	The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines.	Ornithine	64-73	glycine amidinotransferase	Homo sapiens	46-60
7173402-2	1982	Two enzymes are involved in ornithine biosynthesis: arginase and transamidinase.	Ornithine	28-37	glycine amidinotransferase	Homo sapiens	65-79
7173402-4	1982	Arginase activity accounts for the majority of ornithine formed in the highly tumorigenic cell line, while the majority of ornithine is derived from transamidinase action in the poorly tumorigenic cell line, with concomitant formation of methyl guanidine, a potent inhibitor of diamine oxidase.	Ornithine	123-132	glycine amidinotransferase	Homo sapiens	149-163
7287759-2	1981	Homogeneous rat liver carbamyl phosphate synthetase I is activated by ornithine and other amino acids.	Ornithine	70-79	carbamoyl-phosphate synthase 1	Rattus norvegicus	22-53
7287759-7	1981	Previous in vivo studies have shown that carbamyl phosphate synthetase I is rapidly activated by the addition of ornithine.	Ornithine	113-122	carbamoyl-phosphate synthase 1	Rattus norvegicus	41-72
7287759-8	1981	The present in vitro findings, as well as the previous in vivo findings, suggest a regulatory scheme for carbamyl phosphate synthetase I in which (a) the enzyme is inhibited by physiological levels of heavy metal ions and (b) this inhibition can be relieved by the addition of ornithine or other amino acids.	Ornithine	277-286	carbamoyl-phosphate synthase 1	Rattus norvegicus	105-136
6115302-2	1981	Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid.	Ornithine	63-72	aldehyde dehydrogenase 18 family member A1	Homo sapiens	76-116
6797167-0	1981	Decarboxylation of ornithine and lysine by ornithine decarboxylase from kidneys of testosterone treated mice.	Ornithine	19-28	ornithine decarboxylase, structural 1	Mus musculus	43-66
6263582-3	1981	The effectiveness of in vivo treatment with LH in inducing ovarian ornithine decarboxylase (ODC) activity, measured in 20,000 X g supernatants by the in vitro formation of 14CO2 from labeled ornithine, increased significantly during prepubertal development (days 21-33), paralleling the changes in hCG receptors.	Ornithine	67-76	ornithine decarboxylase 1	Rattus norvegicus	92-95
7254777-4	1981	One patient with the poorest control of plasma ornithine has developed a decrease in ERG amplitudes and a new area of chorioretinal atrophy.	Ornithine	47-56	ETS transcription factor ERG	Homo sapiens	85-88
7254778-2	1981	Ornithine-delta-aminotransferase deficiency is the primary biochemical defect in gyrate atrophy of the choroid and retina and results in the characteristic accumulation of ornithine.	Ornithine	172-181	ornithine aminotransferase	Homo sapiens	0-32
7376785-2	1980	An iv infusion of ornithine hydrochloride was given to 23 controls; the induced rise of GH was accompanied by a simultaneous fall of SM (r = -0.711, P less than 0.001) and was preceded by a fall of Tf (r = -0.610, P less than 0.01).	Ornithine	18-41	growth hormone 1	Homo sapiens	88-90
7205129-0	1981	Stimulation by ornithine of ovine placental lactogen secretion.	Ornithine	15-24	chorionic somatomammotropin hormone	Ovis aries	34-52
7205129-7	1981	The results indicate that ornithine is also a potent stimulus to the secretion of PL, GH and prolactin and suggest that arginine-induced PL secretion may result from the conversion of arginine to ornithine.	Ornithine	26-35	chorionic somatomammotropin hormone	Ovis aries	82-84
7205129-7	1981	The results indicate that ornithine is also a potent stimulus to the secretion of PL, GH and prolactin and suggest that arginine-induced PL secretion may result from the conversion of arginine to ornithine.	Ornithine	196-205	chorionic somatomammotropin hormone	Ovis aries	137-139
7208155-3	1980	On the contrary, the apparent Km"s of human liver OTC were 0.6 mM for ornithine and 0.12 mM for carbamyl phosphate.	Ornithine	70-79	ornithine transcarbamylase	Homo sapiens	50-53
6162456-11	1980	Ornithine decarboxylase activity was variable in the diabetic rat, showing a positive correlation with endogenous ornithine concentrations.	Ornithine	114-123	ornithine decarboxylase 1	Rattus norvegicus	0-23
7381232-1	1980	Ornithine decarboxylase which forms putrescine by the decarboxyalation of ornithine, is the first and probably the rate-limiting enzyme in the biosynthesis of the other polyamines, spermidine and spermine.	Ornithine	74-83	ornithine decarboxylase, structural 1	Mus musculus	0-23
7205870-0	1981	alpha-Ethynyl and alpha-vinyl analogues of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase.	Ornithine	43-52	ornithine decarboxylase 1	Homo sapiens	97-120
6775372-1	1980	alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei.	Ornithine	20-29	ornithine decarboxylase, structural 1	Mus musculus	178-201
6991493-1	1980	We isolated several strains of Saccharomyces cerevisiae containing mutations mapping at a single chromosomal gene (spe10); these strains are defective in the decarboxylation of L-ornithine to form putrescine and consequently do not synthesize spermidine and spermine.	Ornithine	177-188	ornithine decarboxylase SPE1	Saccharomyces cerevisiae S288C	115-120
7391521-4	1980	The apparent Km for ornithine (140-280 micro M) was similar for cytosol and cell ODC.	Ornithine	20-29	ornithine decarboxylase	Bos taurus	81-84
7391521-5	1980	Thiol compounds were required for the maximal enzyme activity and there was an absolute requirement for pyridoxal phosphate as a cofactor, with an apparent Km of 15 micro M. There was a modest competitive inhibition of ODC activity by the end products of ornithine catabolism.	Ornithine	255-264	ornithine decarboxylase	Bos taurus	219-222
7376785-2	1980	An iv infusion of ornithine hydrochloride was given to 23 controls; the induced rise of GH was accompanied by a simultaneous fall of SM (r = -0.711, P less than 0.001) and was preceded by a fall of Tf (r = -0.610, P less than 0.01).	Ornithine	18-41	transferrin	Homo sapiens	198-200
7228251-3	1980	The yields of NPYR formed from pyrrolidine, putrescine, agmatine, spermidine, spermine, proline, ornithine and arginine with nitrite in the pH range 6.6 to 4.0 were determined.	Ornithine	97-106	neuropeptide Y receptor Y1	Homo sapiens	14-18
7378422-2	1980	The inhibitory effect of ornithine on L-arginine:glycine amidinotransferase (EC 2.1.4.1) was studied in crude rat kidney homogenates.	Ornithine	25-34	glycine amidinotransferase	Rattus norvegicus	38-75
378940-4	1979	Mutants defective in the pro1 and pro2 genes can be satisfied by arginine or ornithine as well as proline.	Ornithine	77-86	glutamate 5-kinase	Saccharomyces cerevisiae S288C	25-29
393602-0	1979	Kinetic properties and regulation by L-ornithine of chicken liver arginase induced by insulin.	Ornithine	37-48	insulin	Gallus gallus	86-93
442084-4	1979	(3) The CCl4-induced liver dysfunction group showed a significantly higher level of arginine synthetase activity than the group with 6 weeks of biliary obstruction, but ammonia removal was markedly decreased and the effects of ATP and ornithine addition were prominent.	Ornithine	235-244	C-C motif chemokine ligand 4	Rattus norvegicus	8-12
429491-3	1979	The mutant OTC showed an increased apparent Km for ornithine and an increased pH optimum.	Ornithine	51-60	ornithine transcarbamylase	Homo sapiens	11-14
438294-1	1979	Ornithine aminotransferase catalyzes the reversible transamination of L-ornithine to delta1-pyrroline-5-carboxylate, the immediate precursor of proline.	Ornithine	70-81	ornithine aminotransferase	Homo sapiens	0-26
762194-2	1979	A multi-step selection procedure is described which selects from HR-II-E populations, cells with OCT activity which can grow in arginine-deficient, ornithine-supplemented media.	Ornithine	148-157	ornithine transcarbamylase	Rattus norvegicus	97-100
729890-5	1978	Km (ornithine) of the patient"s ornithine transcarbamylase was within the normal range (0.41 nM), but the Km (carbamyl phosphate) was low (0.18 mM).	Ornithine	4-13	ornithine transcarbamylase	Homo sapiens	32-58
589799-1	1977	Ornithine carbamoyltransferase (EC 2.1.3.3) activity in human liver homogenates has been measured using 14C-labeled ornithine and unlabeled carbamoyl phosphate.	Ornithine	116-125	ornithine transcarbamylase	Homo sapiens	0-30
619149-0	1978	Analogues of ornithine as inhibitors of ornithine decarboxylase.	Ornithine	13-22	ornithine decarboxylase 1	Rattus norvegicus	40-63
619149-2	1978	Fourteen structural analogues of ornithine were synthesized and evaluated as inhibitors of preparations of the enzyme L-ornithine carboxylase (ODC) (E.C.	Ornithine	33-42	ornithine decarboxylase 1	Rattus norvegicus	143-146
619149-6	1978	From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site.	Ornithine	77-86	ornithine decarboxylase 1	Homo sapiens	33-36
619149-6	1978	From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site.	Ornithine	77-86	ornithine decarboxylase 1	Homo sapiens	241-244
619149-6	1978	From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site.	Ornithine	181-192	ornithine decarboxylase 1	Homo sapiens	33-36
619149-6	1978	From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site.	Ornithine	181-192	ornithine decarboxylase 1	Homo sapiens	241-244
977659-7	1976	The Km of ODC for ornithine is 0.12 mM.	Ornithine	18-27	ornithine decarboxylase, structural 1	Mus musculus	10-13
909953-2	1977	In hypophysectomized rats, found to oxidize ornithine at rates comparable to those of normal rats, an acute treatment of growth hormone 4 hours before injection of L-ornithine-1-14C caused a 39% increase in the peak specific activity of carbon dioxide and a 24% increase in the 14CO2 recovered in 5 hours.	Ornithine	44-53	gonadotropin releasing hormone receptor	Rattus norvegicus	121-135
885138-2	1977	It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner.	Ornithine	62-71	argininosuccinate lyase	Homo sapiens	25-48
836898-2	1977	The inhibition by L-leucine is largely overcome by addition of 1 mM L-ornithine, suggesting that the main site of L-leucine action is at ornithine transcarbamylase, rather than at glutamate dyhydrogenase.	Ornithine	68-79	ornithine transcarbamylase	Rattus norvegicus	137-163
1151975-6	1975	A number of alpha-alkyl- and alpha-aralkyl-substituted analogs of (+/-)-ornithine were synthesized and evaluated in vitro as inhibitors of the enzyme L-ornithine decarboxylase obtained from prostate glands of rats.	Ornithine	66-81	ornithine decarboxylase 1	Rattus norvegicus	152-175
1064034-5	1976	Cell proliferation is also restored by L-ornithine presumably due to in situ competitive inhibition of ornithine decarboxylase.	Ornithine	39-50	ornithine decarboxylase 1	Rattus norvegicus	103-126
4660448-0	1972	[Effect of ornithine hydrochloride on growth hormone (HGH) plasma levels].	Ornithine	11-34	growth hormone 1	Homo sapiens	38-52
1150642-2	1975	Using partially enzyme preparations, it was found that DL-HAVA strongly inhibited ornithine decarboxylase (EC 4.1.1.17) by competing with L-ornithine.	Ornithine	138-149	ornithine decarboxylase, structural 1	Mus musculus	82-105
1150642-3	1975	Other enzymes metabolizing ornithine and pyridoxal phosphate-dependent enzymes were at least 2-3 orders of magnitude less sensitive to DL-HAVA than ornithine decarboxylase.	Ornithine	27-36	ornithine decarboxylase, structural 1	Mus musculus	148-171
58543-2	1975	It is demonstrated that among the aminoacyl adenylate binding sites of the heavy component of GSS the activation site of L-ornithine is distinguished by a relatively high substrate variability.	Ornithine	121-132	glutathione synthetase	Homo sapiens	94-97
14058941-7	1963	The conversion of arginine to ornithine in PPLO-contaminated cell culture was rapid, and occurred by the arginine dihydrolase pathway involving arginine deiminase, ornithine transcarbamylase, and carbamyl phosphokinase.	Ornithine	30-39	ornithine transcarbamylase	Homo sapiens	164-190
4672804-3	1972	Occurrence of the urea cycle can be excluded since two enzymes for the further reaction of ornithine in the cycle, carbamoyl phosphate synthetase I and ornithine carbamoyltransferase, are both absent from this tissue.	Ornithine	91-100	carbamoyl-phosphate synthase 1	Rattus norvegicus	115-147
34050775-5	2021	The IR binding assay was used to determine unknown amounts of insulin secreted by MIN6 beta cell line after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.	Ornithine	144-153	insulin	Homo sapiens	62-69
34050775-0	2021	A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.	Ornithine	127-136	insulin	Homo sapiens	54-61
33500272-3	2021	Pegzilarginase, a human arginase 1 enzyme engineered to have superior stability and enzymatic activity relative to the native human arginase 1 enzyme, depletes systemic arginine by converting it to ornithine and urea.	Ornithine	198-207	arginase 1	Homo sapiens	24-34
33891387-13	2021	Conversely, citrulline, N-acetylornithine and ornithine were significantly elevated in the presence of hFB1 but not any of the other fumonisin analogues.	Ornithine	32-41	TCF3 fusion partner	Homo sapiens	103-107
33950277-11	2021	Moreover, the genes involved in ornithine pathway (Orn-OAT-P5C/GSA-P5CR-Pro) were up-regulated along with the up-regulation of those genes involved in glutamate pathway (Glu-P5CS-P5C/GSA-P5CR-Pro).	Ornithine	32-41	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	67-71
33950277-11	2021	Moreover, the genes involved in ornithine pathway (Orn-OAT-P5C/GSA-P5CR-Pro) were up-regulated along with the up-regulation of those genes involved in glutamate pathway (Glu-P5CS-P5C/GSA-P5CR-Pro).	Ornithine	32-41	pyrroline-5- carboxylate (P5C) reductase	Arabidopsis thaliana	187-191
33915902-3	2021	Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth.	Ornithine	12-21	ornithine decarboxylase 1	Homo sapiens	95-118
33915902-3	2021	Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth.	Ornithine	12-21	ornithine decarboxylase 1	Homo sapiens	120-123
33915902-3	2021	Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth.	Ornithine	12-21	ornithine decarboxylase 1	Homo sapiens	139-143
33754845-1	2021	Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and represents an interesting therapeutic target in immuno-oncology.	Ornithine	67-78	arginase 1	Homo sapiens	0-10
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Ornithine	103-112	solute carrier family 7 member 1	Homo sapiens	0-6
33621898-7	2021	The N5-[18F]FPO exhibited fast uptake in HepG2 cells and the cellular uptake ability of N5-[18F]FPO can be inhibited by L-ornithine and DFMO, which indicated that the transport pathway of N5-[18F]FPO is similar to that of L-ornithine, interacting with ODC after being transported into the cell.	Ornithine	120-131	ornithine decarboxylase 1	Homo sapiens	252-255
33573605-11	2021	Analysis of serum amino acid levels revealed that two SPG9A patients and two unaffected family members had low citrulline levels and one had a low level of ornithine.	Ornithine	156-165	aldehyde dehydrogenase 18 family member A1	Homo sapiens	54-59
33586680-5	2021	Dysregulation of gene transcripts associated with polyamine metabolism in Alzheimer"s disease (AD) brains were observed, and we found that ornithine decarboxylase antizyme inhibitor 2 (AZIN2) increased to the greatest extent.	Ornithine	139-148	antizyme inhibitor 2	Mus musculus	185-190
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Ornithine	103-112	solute carrier family 7 member 1	Homo sapiens	7-11
33542926-8	2021	mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes.	Ornithine	103-112	CREB regulated transcription coactivator 1	Mus musculus	0-6
33542926-8	2021	mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes.	Ornithine	103-112	nuclear factor kappa B subunit 1	Homo sapiens	19-28
33542926-8	2021	mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes.	Ornithine	103-112	solute carrier family 17 member 5	Homo sapiens	62-65
33542926-8	2021	mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes.	Ornithine	103-112	ornithine decarboxylase 1	Homo sapiens	70-73
33542926-8	2021	mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes.	Ornithine	186-195	CREB regulated transcription coactivator 1	Mus musculus	0-6
33428938-7	2021	Given that, among GPR6CA ligands tested, GluOC and ornithine increased the expression of ATGL in cultured 3T3-L1 adipocytes in a manner dependent on GPRC6A, our results suggest that the constitutive activation of GPRC6A signaling in adipocytes by GluOC or ornithine plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.	Ornithine	51-60	patatin-like phospholipase domain containing 2	Mus musculus	89-93
33428938-7	2021	Given that, among GPR6CA ligands tested, GluOC and ornithine increased the expression of ATGL in cultured 3T3-L1 adipocytes in a manner dependent on GPRC6A, our results suggest that the constitutive activation of GPRC6A signaling in adipocytes by GluOC or ornithine plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.	Ornithine	51-60	G protein-coupled receptor, family C, group 6, member A	Mus musculus	149-155
33428938-7	2021	Given that, among GPR6CA ligands tested, GluOC and ornithine increased the expression of ATGL in cultured 3T3-L1 adipocytes in a manner dependent on GPRC6A, our results suggest that the constitutive activation of GPRC6A signaling in adipocytes by GluOC or ornithine plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.	Ornithine	256-265	patatin-like phospholipase domain containing 2	Mus musculus	89-93
33428938-7	2021	Given that, among GPR6CA ligands tested, GluOC and ornithine increased the expression of ATGL in cultured 3T3-L1 adipocytes in a manner dependent on GPRC6A, our results suggest that the constitutive activation of GPRC6A signaling in adipocytes by GluOC or ornithine plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.	Ornithine	256-265	G protein-coupled receptor, family C, group 6, member A	Mus musculus	213-219
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Ornithine	147-156	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
33068755-3	2021	OAT is mainly involved in ornithine catabolism in adults, thus explaining the hyperornithinemia as hallmark of the disease.	Ornithine	26-35	ornithine aminotransferase	Homo sapiens	0-3
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Ornithine	147-156	aldehyde dehydrogenase 18 family member A1	Homo sapiens	34-38
33181436-4	2020	OTC, which is a widely distributed enzyme in microorganisms, mammals, and higher plants, catalyzes the conversion of ornithine to citrulline.	Ornithine	117-126	ornithine transcarbamylase	Sus scrofa	0-3
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Ornithine	34-43	ornithine decarboxylase 1	Sus scrofa	84-107
33364460-1	2020	l-proline (Pro) is a precursor of ornithine, which is converted into polyamines via ornithine decarboxylase (ODC).	Ornithine	34-43	ornithine decarboxylase 1	Sus scrofa	109-112
33128544-1	2020	Arginase I (ARG1) is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.	Ornithine	87-98	arginase 1	Homo sapiens	12-16
32980952-1	2020	Cationic amino acid transporter 1 (Cat-1 alias Slc7a1) is a Na+-independent carrier system involved in transport and absorption of the cationic amino acids lysine, arginine, histidine, and ornithine and has also been shown to be indispensable in a large variety of biological processes.	Ornithine	189-198	solute carrier family 7 member 1a	Danio rerio	47-53
32721946-1	2020	Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects.	Ornithine	50-59	arginase, liver	Mus musculus	0-10
32721946-1	2020	Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects.	Ornithine	50-59	arginase, liver	Mus musculus	12-16
32899962-7	2020	Moreover, increased proline oxidation capacity was detected in MPC1def flies, which was associated with generally lower levels of several metabolites, and particularly those involved in amino acid catabolism such as ornithine, citrulline, and arginosuccinate.	Ornithine	216-225	Mitochondrial pyruvate carrier	Drosophila melanogaster	63-70
32721242-1	2020	Background: Arginase I, encoded by the ARG1 gene, is an enzyme that catalyzes the conversion of arginine to ornithine in the urea cycle; mutations in this gene has recently been reported to be associated with dilated cardiomyopathy (DCM) in Pakistan.	Ornithine	108-117	arginase 1	Homo sapiens	39-43
32848891-7	2020	OPN positively correlates with 2,3-dinor-8isoPGF2a levels (p = 0.02), ornithine (p = 0.01), ADMA (p = 0.001), SDMA (p = 0.03), and citrulline (p = 0.008) levels only in CAD patients.	Ornithine	70-79	secreted phosphoprotein 1	Homo sapiens	0-3
32504080-1	2020	Lysinuric protein intolerance (LPI) is an inborn error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallelic pathogenic variants in SLC7A7, which encodes the light subunit of the y+LAT1 transporter.	Ornithine	97-106	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	Mus musculus	161-167
33192610-5	2020	For example, through a combination of steady state measurements and 13C6 15N4-arginine tracing experiments, we report an increase in arginine catabolism into ornithine in humans, suggestive of species-specific arginase 1 activity and nitric oxide synthesis-an observation that may impact the translatability of cardiovascular disease studies carried out in non-human primates (NHPs).	Ornithine	158-167	arginase 1	Homo sapiens	210-220
32418491-1	2020	Arginase-1, which converts the amino acid L-arginine into L-ornithine and urea, is a promising new drug target for cancer immunotherapy, as it has a role in the regulation of T-cell immunity in the tumor microenvironment.	Ornithine	58-69	arginase 1	Homo sapiens	0-10
32767470-4	2020	In the catalysis axis (pathway), ODC converts ornithine to putrescine.	Ornithine	46-55	ornithine decarboxylase 1	Homo sapiens	33-36
32882842-6	2020	OAT is the main catabolic enzyme for ornithine, and its expression was significantly decreased by tryptophan administration.	Ornithine	37-46	ornithine aminotransferase	Rattus norvegicus	0-3
32882842-11	2020	We speculate that the increase in ornithine level through suppression of OAT expression by tryptophan administration may lead to accelerated polyamine synthesis, thereby promoting protein synthesis in the liver.	Ornithine	34-43	ornithine aminotransferase	Rattus norvegicus	73-76