PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2671661-2 1989 The pso4-1 mutant strain was found to be completely blocked in mitotic recombination induced by photoaddition of mono- and bifunctional psoralen derivatives as well as by mono- (HN1) and bifunctional (HN2) nitrogen mustards or 254 nm UV radiation in both stationary and exponential phases of growth. Ficusin 136-144 E3 ubiquitin-protein ligase PRP19 Saccharomyces cerevisiae S288C 4-8 3790492-1 1986 We have carried out a thermodynamic study on the effects of covalent additions of the psoralen derivative HMT, 4"-(hydroxymethyl)-4,5",8-trimethylpsoralen, on the stability of double-stranded deoxyoligonucleotides. Ficusin 86-94 histamine N-methyltransferase Homo sapiens 106-109 2727077-1 1989 Single-crystal x-ray diffraction methods have been used to directly observe and simultaneously determine the molecular structure of the UVA induced cis-syn photocycloaddition product in a partially photolyzed single crystal of a psoralen(pyrone ring side)-DNA(thymine) interaction model compound, 1"-(8-oxypsoralen)-8"(thym-1"yl)3",6"-dioxaoctane. Ficusin 229-237 synemin Homo sapiens 152-155 3494453-0 1987 Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives. Ficusin 79-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-44 3494453-1 1987 The effects of psoralen derivatives on cytochrome P-450 have been studied in human liver microsomes. Ficusin 15-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-55 3735138-3 1986 CO-binding cytochrome P-450 decreased when hepatic microsomes were incubated for 10 min with an NADPH-generating system and 8-methoxypsoralen, 5-methoxypsoralen or psoralen (400 microM), but remained unchanged with trioxsalen (400 microM). Ficusin 133-141 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 11-27 6616056-1 1983 Photosensitized luminescence of singlet (1 delta g) molecular oxygen with the maximum at 1272 nm has been found in solutions of psoralen, angelicin and 8-methoxypsoralen in CCl4. Ficusin 128-136 C-C motif chemokine ligand 4 Homo sapiens 173-177 3832664-9 1985 In addition to the psoralens, the light activation of two other compounds, gilvocarcin and an insulin-psoralen conjugate, is described. Ficusin 19-27 insulin Homo sapiens 94-101 4029504-6 1985 The effects of pulses of restrictive temperature and psoralen treatment on fem-2 mutant hermaphrodites are additive, suggesting that psoralen crosslinking may reduce the level of the fem-2 gene product. Ficusin 53-61 Protein phosphatase fem-2 Caenorhabditis elegans 75-80 4029504-6 1985 The effects of pulses of restrictive temperature and psoralen treatment on fem-2 mutant hermaphrodites are additive, suggesting that psoralen crosslinking may reduce the level of the fem-2 gene product. Ficusin 53-61 Protein phosphatase fem-2 Caenorhabditis elegans 183-188 6600397-0 1983 Ornithine decarboxylase induction in psoralen-treated mouse epidermis used as a test of UV-A sunscreen potency. Ficusin 37-45 ornithine decarboxylase, structural 1 Mus musculus 0-23 7009316-5 1980 The mutant pso1--1 demonstrates a cross-sensitivity to UV and gamma-rays, whereas mutants pso2--1 and pso3--1 are specifically sensitive to photo-addition of psoralen derivatives. Ficusin 158-166 DNA cross-link repair protein PSO2 Saccharomyces cerevisiae S288C 90-94 7096664-0 1982 Psoralen-containing sunscreen induces phototoxicity and epidermal ornithine decarboxylase activity. Ficusin 0-8 ornithine decarboxylase 1 Homo sapiens 66-89 7035927-9 1981 In contrast with psoralen photo-induced inactivation the pso3-1 mutant had the same sensitivity as the wild-type to alkylating agents. Ficusin 17-25 ribonucleotide-diphosphate reductase subunit RNR4 Saccharomyces cerevisiae S288C 57-61 7035927-12 1981 Consequently, it appeared that the PSO3+ gene product acts specifically on psoralen photo-induced sub-lethal lesions and on a fraction of premutagenic lesions independently of their structure. Ficusin 75-83 ribonucleotide-diphosphate reductase subunit RNR4 Saccharomyces cerevisiae S288C 35-39 33317360-5 2021 The results showed that psoralen could induce hepatotoxicity by enhanced liver-to-body weight ratio and alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total cholesterol after administration for 3 days. Ficusin 24-32 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 157-183 33317360-5 2021 The results showed that psoralen could induce hepatotoxicity by enhanced liver-to-body weight ratio and alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total cholesterol after administration for 3 days. Ficusin 24-32 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 185-188 33839980-8 2021 The expression of NOD2 protein in the intestinal tract of periodontitis rats decreased after intragastric psoralen administration. Ficusin 106-114 nucleotide-binding oligomerization domain containing 2 Rattus norvegicus 18-22 33839980-12 2021 Psoralen decreased the RANKL/OPG ratio of periodontitis rats. Ficusin 0-8 TNF superfamily member 11 Rattus norvegicus 23-28 33839980-12 2021 Psoralen decreased the RANKL/OPG ratio of periodontitis rats. Ficusin 0-8 TNF receptor superfamily member 11B Rattus norvegicus 29-32 33839980-13 2021 Psoralen may affect the intestinal immune barrier and ecological barrier, mediate immune response, promote the secretion of anti-inflammatory factor IL-10, and reduce the secretion of the pro-inflammatory factor TNF-alpha, thus reducing ABL in experimental periodontitis in rats. Ficusin 0-8 interleukin 10 Rattus norvegicus 149-154 33839980-13 2021 Psoralen may affect the intestinal immune barrier and ecological barrier, mediate immune response, promote the secretion of anti-inflammatory factor IL-10, and reduce the secretion of the pro-inflammatory factor TNF-alpha, thus reducing ABL in experimental periodontitis in rats. Ficusin 0-8 tumor necrosis factor Rattus norvegicus 212-221 32862473-2 2021 Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling. Ficusin 16-24 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 258-263 33755208-6 2021 STUDY DESIGN AND METHODS: Hemostatic adjunct study products were psoralen-treated PR-cryoprecipitated fibrinogen complex (PR-Cryo FC), cryoprecipitate (Cryo), and fibrinogen concentrates (FibCon). Ficusin 65-73 fibrinogen beta chain Homo sapiens 102-112 33557643-2 2021 Previously, we have found that psoralen induced hepatocytes apoptosis via PERK and ATF6 related ER stress pathways in vitro. Ficusin 31-39 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 74-78 33557643-2 2021 Previously, we have found that psoralen induced hepatocytes apoptosis via PERK and ATF6 related ER stress pathways in vitro. Ficusin 31-39 activating transcription factor 6 Mus musculus 83-87 32862473-2 2021 Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling. Ficusin 16-24 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 265-308 32862473-2 2021 Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling. Ficusin 16-24 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 314-319 32862473-2 2021 Clinically used psoralen derivatives 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen at physiologically relevant concentrations were able to activate and photosensitize two recombinant thermoTRP (temperature-gated Transient Receptor Potential) ion channels, TRPA1 (Transient Receptor Potential Ankyrin type 1) and TRPV1 (Transient Receptor Potential Vanilloid type 1), which are known to be involved in pain and itch signaling. Ficusin 16-24 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 321-366 31392348-6 2020 Here, we imaged GFP-tagged ERCC1, XPF and ICLR-defective XPF mutants to investigate how in human cells ERCC1-XPF is localized to different types of psoralen-induced DNA lesions, repaired by either NER or ICLR. Ficusin 148-156 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 103-108 32698907-0 2020 Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874. Ficusin 0-8 SMAD family member 2 Homo sapiens 75-81 32698907-12 2020 Western blot assays indicated that psoralen could reverse HG-induced increase of TLR-4/NF-kappaB and Smad2 via upregulation of miR-874. Ficusin 35-43 toll like receptor 4 Homo sapiens 81-86 32698907-12 2020 Western blot assays indicated that psoralen could reverse HG-induced increase of TLR-4/NF-kappaB and Smad2 via upregulation of miR-874. Ficusin 35-43 nuclear factor kappa B subunit 1 Homo sapiens 87-96 32698907-12 2020 Western blot assays indicated that psoralen could reverse HG-induced increase of TLR-4/NF-kappaB and Smad2 via upregulation of miR-874. Ficusin 35-43 SMAD family member 2 Homo sapiens 101-106 32698907-12 2020 Western blot assays indicated that psoralen could reverse HG-induced increase of TLR-4/NF-kappaB and Smad2 via upregulation of miR-874. Ficusin 35-43 microRNA 874 Homo sapiens 127-134 32698907-13 2020 CONCLUSION: This study demonstrated that psoralen could significantly alleviate HG-induced HK-2 cell injury via upregulation of miR-874. Ficusin 41-49 microRNA 874 Homo sapiens 128-135 32405369-7 2020 Results: TNF-alpha (1, 10, 20 and 100 ng/ml) treatment inhibited C2C12 myoblast viability (P<0.001), while 24 hr of psoralen administration increased the viability, and lowered TNF-alpha cytotoxicity (P<0.001). Ficusin 116-124 tumor necrosis factor Mus musculus 177-186 32259795-0 2020 Reversal of multidrug resistance in leukemia cells using a transferrin-modified nanomicelle encapsulating both doxorubicin and psoralen. Ficusin 127-135 transferrin Homo sapiens 59-70 32259795-11 2020 Finally, the reversal of the drug resistance when cells are exposed to Tf-M-DOX/PSO was associated with P-gp expression inhibition. Ficusin 80-83 phosphoglycolate phosphatase Homo sapiens 104-108 32981282-10 2020 Conclusion: Psoralen prevents osteoblasts injuries caused by TCP wear particles through IRE1alpha-XBP1s-JNK signaling pathway activation. Ficusin 12-20 mitogen-activated protein kinase 8 Rattus norvegicus 104-107 32368152-0 2020 Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis. Ficusin 0-8 homeobox B7 Homo sapiens 127-132 32368152-0 2020 Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis. Ficusin 0-8 erb-b2 receptor tyrosine kinase 2 Homo sapiens 133-137 32368152-7 2020 Furthermore, psoralen reversed miR-196a-5p-induced DDP resistance and reduced the expression levels of HOXB7, HER2, Bcl-2 and CCND1. Ficusin 13-21 homeobox B7 Homo sapiens 103-108 32368152-7 2020 Furthermore, psoralen reversed miR-196a-5p-induced DDP resistance and reduced the expression levels of HOXB7, HER2, Bcl-2 and CCND1. Ficusin 13-21 erb-b2 receptor tyrosine kinase 2 Homo sapiens 110-114 32368152-7 2020 Furthermore, psoralen reversed miR-196a-5p-induced DDP resistance and reduced the expression levels of HOXB7, HER2, Bcl-2 and CCND1. Ficusin 13-21 BCL2 apoptosis regulator Homo sapiens 116-121 32368152-7 2020 Furthermore, psoralen reversed miR-196a-5p-induced DDP resistance and reduced the expression levels of HOXB7, HER2, Bcl-2 and CCND1. Ficusin 13-21 cyclin D1 Homo sapiens 126-131 32368152-9 2020 Moreover, psoralen can increase chemotherapeutic sensitivity by upregulating miR-196a-5p and then downregulating HOXB7-HER2 signaling axis. Ficusin 10-18 homeobox B7 Homo sapiens 113-118 32368152-9 2020 Moreover, psoralen can increase chemotherapeutic sensitivity by upregulating miR-196a-5p and then downregulating HOXB7-HER2 signaling axis. Ficusin 10-18 erb-b2 receptor tyrosine kinase 2 Homo sapiens 119-123 32280872-7 2020 HepG2 cells were exposed to low doses (5, 10, 20, or 40 muM) of psoralen for 1, 2, 3, or 4 days. Ficusin 64-72 latexin Homo sapiens 56-59 32280872-8 2020 A 20 and 40 muM dose of psoralen did not induced cell death in the 1st day but significantly decreased the cell viability at the 3rd and 4th day of repeated administration, respectively. Ficusin 24-32 latexin Homo sapiens 12-15 32405369-10 2020 miR-675-5P was increased in TNF-alpha-treated C2C12 myoblasts compared to control group, and it was significantly decreased after psoralen treatment. Ficusin 130-138 microRNA 675 Mus musculus 0-7 32405369-10 2020 miR-675-5P was increased in TNF-alpha-treated C2C12 myoblasts compared to control group, and it was significantly decreased after psoralen treatment. Ficusin 130-138 tumor necrosis factor Mus musculus 28-37 32405369-11 2020 Conclusion: Psoralen could reduce TNF-alpha-induced cytotoxicity, atrophy and apoptosis in C2C12 myoblasts. Ficusin 12-20 tumor necrosis factor Mus musculus 34-43 32405369-12 2020 The therapeutic effect of psoralen may be achieved by down-regulating miR-675-5P. Ficusin 26-34 microRNA 675 Mus musculus 70-77 30621711-0 2019 Effect of psoralen on the expression of PPARgamma, osteocalcin, and trabecular bone area in rabbits with steroid-induced avascular necrosis of the femoral head. Ficusin 10-18 peroxisome proliferator-activated receptor gamma Oryctolagus cuniculus 40-49 31233340-5 2019 This compound further screened by applying molecular docking simulation identified five potential hits such as osthole, kavain, vanillyl acetone, myristicin, and psoralen, having a comparable binding affinity to COX-2 protein. Ficusin 162-170 prostaglandin-endoperoxide synthase 2 Homo sapiens 212-217 31277690-7 2019 Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Ficusin 0-8 cyclin D1 Homo sapiens 60-68 31277690-7 2019 Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Ficusin 0-8 cyclin E1 Homo sapiens 82-90 31364909-0 2020 Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells. Ficusin 0-8 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 42-46 31364909-0 2020 Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells. Ficusin 0-8 activating transcription factor 6 Homo sapiens 51-55 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 119-123 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 eukaryotic translation initiation factor 2A Homo sapiens 124-133 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 activating transcription factor 4 Homo sapiens 134-138 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 DNA damage inducible transcript 3 Homo sapiens 139-143 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 activating transcription factor 6 Homo sapiens 148-152 31364909-10 2020 These results suggested that psoralen causes liver injury due to the induction of the ER stress-mediated apoptosis via PERK-eIF2alpha-ATF4-CHOP and ATF6-CHOP related pathways. Ficusin 29-37 DNA damage inducible transcript 3 Homo sapiens 153-157 31271704-6 2019 RESULTS: Psoralen administration significantly up-regulated serum AST (aspartate aminotransferase) while addition of isopsoralen increased serum ALT (alanine aminotransferase), AST, TBA (total bile acid) and TG (total triglyceride) levels. Ficusin 9-17 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 66-69 31271704-6 2019 RESULTS: Psoralen administration significantly up-regulated serum AST (aspartate aminotransferase) while addition of isopsoralen increased serum ALT (alanine aminotransferase), AST, TBA (total bile acid) and TG (total triglyceride) levels. Ficusin 9-17 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 71-97 31355570-0 2019 [Psoralen and isopsoralen improve lipid metabolism disorder via inhibition of NF-kappaB activation in LO2 cells]. Ficusin 1-9 nuclear factor kappa B subunit 1 Homo sapiens 78-87 30702934-4 2019 Meanwhile, psoralen induced osteogenic differentiation by promoting the mRNA expression of the osteoblast differentiation markers alkaline phosphatase, runt-related transcription factor 2, osterix, and osteocalcin. Ficusin 11-19 RUNX family transcription factor 2 Rattus norvegicus 152-187 30702934-4 2019 Meanwhile, psoralen induced osteogenic differentiation by promoting the mRNA expression of the osteoblast differentiation markers alkaline phosphatase, runt-related transcription factor 2, osterix, and osteocalcin. Ficusin 11-19 Sp7 transcription factor Rattus norvegicus 189-196 30702934-4 2019 Meanwhile, psoralen induced osteogenic differentiation by promoting the mRNA expression of the osteoblast differentiation markers alkaline phosphatase, runt-related transcription factor 2, osterix, and osteocalcin. Ficusin 11-19 bone gamma-carboxyglutamate protein Rattus norvegicus 202-213 30702934-6 2019 Further experiments revealed that psoralen-induced osteoclast and osteoblast differentiation was abrogated by a specific inhibitor of phosphorylated ERK. Ficusin 34-42 Eph receptor B1 Rattus norvegicus 149-152 30022950-1 2018 The psoralen-related compound, 4,6,4"-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. Ficusin 4-12 CF transmembrane conductance regulator Homo sapiens 115-119 30459602-10 2018 The further mechanism researches indicated that psoralen-induced hepatotoxicity was associated with inhibition of mTOR signalling pathway and mitochondrial injury; furthermore, MHY, an mTOR activator, partly alleviated the inhibition of mTOR and S-phase cycle arrest induced by psoralen in L02 cells. Ficusin 48-56 mechanistic target of rapamycin kinase Homo sapiens 114-118 30459602-10 2018 The further mechanism researches indicated that psoralen-induced hepatotoxicity was associated with inhibition of mTOR signalling pathway and mitochondrial injury; furthermore, MHY, an mTOR activator, partly alleviated the inhibition of mTOR and S-phase cycle arrest induced by psoralen in L02 cells. Ficusin 48-56 mechanistic target of rapamycin kinase Homo sapiens 185-189 30459602-10 2018 The further mechanism researches indicated that psoralen-induced hepatotoxicity was associated with inhibition of mTOR signalling pathway and mitochondrial injury; furthermore, MHY, an mTOR activator, partly alleviated the inhibition of mTOR and S-phase cycle arrest induced by psoralen in L02 cells. Ficusin 48-56 mechanistic target of rapamycin kinase Homo sapiens 185-189 30459602-11 2018 In conclusion, in this study we showed for the first time, that psoralen significantly induced liver injury in mice; the decrease of liver regenerative and compensatory capabilities induced by hepatocellular cycle arrest may play an important role in the progression of hepatotoxicity associated with the upregulation of cyclin E1 and p27, as well as the inhibition of mTOR signalling and mitochondrial injury. Ficusin 64-72 cyclin E1 Mus musculus 321-330 30459602-11 2018 In conclusion, in this study we showed for the first time, that psoralen significantly induced liver injury in mice; the decrease of liver regenerative and compensatory capabilities induced by hepatocellular cycle arrest may play an important role in the progression of hepatotoxicity associated with the upregulation of cyclin E1 and p27, as well as the inhibition of mTOR signalling and mitochondrial injury. Ficusin 64-72 cyclin-dependent kinase inhibitor 1B Mus musculus 335-338 30459602-11 2018 In conclusion, in this study we showed for the first time, that psoralen significantly induced liver injury in mice; the decrease of liver regenerative and compensatory capabilities induced by hepatocellular cycle arrest may play an important role in the progression of hepatotoxicity associated with the upregulation of cyclin E1 and p27, as well as the inhibition of mTOR signalling and mitochondrial injury. Ficusin 64-72 mechanistic target of rapamycin kinase Mus musculus 369-373 30228287-0 2018 Psoralen induced cell cycle arrest by modulating Wnt/beta-catenin pathway in breast cancer cells. Ficusin 0-8 catenin beta 1 Homo sapiens 53-65 30228287-3 2018 The effects of psoralen on activation of Wnt/beta-catenin and the related target genes were examined by quantitative real-time PCR, western blotting and cell immunofluorescence. Ficusin 15-23 catenin beta 1 Homo sapiens 45-57 30228287-6 2018 The expression of Fra-1 was reduced and Axin2 was promoted both in MCF-7 and MDA-MB-231 cells after psoralen treatment. Ficusin 100-108 FOS like 1, AP-1 transcription factor subunit Homo sapiens 18-23 30228287-6 2018 The expression of Fra-1 was reduced and Axin2 was promoted both in MCF-7 and MDA-MB-231 cells after psoralen treatment. Ficusin 100-108 axin 2 Homo sapiens 40-45 30228287-7 2018 The cytoplasmic accumulation and nuclear translocation of beta-catenin were significantly reduced by psoralen. Ficusin 101-109 catenin beta 1 Homo sapiens 58-70 30228287-8 2018 Psoralen increased the levels of phospho-(Y142) beta-catenin, while decreased the expression of total beta-catenin and its downstream target Fra-1 in vitro and vivo. Ficusin 0-8 catenin beta 1 Homo sapiens 48-60 30228287-8 2018 Psoralen increased the levels of phospho-(Y142) beta-catenin, while decreased the expression of total beta-catenin and its downstream target Fra-1 in vitro and vivo. Ficusin 0-8 catenin beta 1 Homo sapiens 102-114 30228287-8 2018 Psoralen increased the levels of phospho-(Y142) beta-catenin, while decreased the expression of total beta-catenin and its downstream target Fra-1 in vitro and vivo. Ficusin 0-8 FOS like 1, AP-1 transcription factor subunit Homo sapiens 141-146 30022950-1 2018 The psoralen-related compound, 4,6,4"-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. Ficusin 4-12 CF transmembrane conductance regulator Homo sapiens 140-144 30110702-8 2018 Both psoralen and bakuchiol significantly inhibited TRACP enzyme activity and slightly decreased the number of TRACP+ multinuclear osteoclasts induced by M-CSF plus RANKL. Ficusin 5-13 acid phosphatase 5, tartrate resistant Mus musculus 52-57 29512683-0 2018 A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells. Ficusin 8-16 mitogen-activated protein kinase 14 Mus musculus 74-82 29512683-3 2018 In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity. Ficusin 90-98 tyrosinase Mus musculus 144-154 29676133-1 2018 This paper aimed to investigate whether psoralen inhibits the differentiation and bone resorption by regulating CD4+T cell differentiation in RANKL-induced osteoclastogenesis in RAW264.7 cells, and elucidate its mechanism for osteoporosis. Ficusin 40-48 CD4 antigen Mus musculus 112-115 29676133-1 2018 This paper aimed to investigate whether psoralen inhibits the differentiation and bone resorption by regulating CD4+T cell differentiation in RANKL-induced osteoclastogenesis in RAW264.7 cells, and elucidate its mechanism for osteoporosis. Ficusin 40-48 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 142-147 29922598-8 2018 Psoralen and angelicin also markedly decreased the mRNA expression and release of inflammatory cytokines (interleukin [IL]-1beta and IL-8) by THP-1 cells in a dose-dependent manner. Ficusin 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 30110702-8 2018 Both psoralen and bakuchiol significantly inhibited TRACP enzyme activity and slightly decreased the number of TRACP+ multinuclear osteoclasts induced by M-CSF plus RANKL. Ficusin 5-13 acid phosphatase 5, tartrate resistant Mus musculus 111-116 30110702-8 2018 Both psoralen and bakuchiol significantly inhibited TRACP enzyme activity and slightly decreased the number of TRACP+ multinuclear osteoclasts induced by M-CSF plus RANKL. Ficusin 5-13 colony stimulating factor 1 (macrophage) Mus musculus 154-159 30110702-8 2018 Both psoralen and bakuchiol significantly inhibited TRACP enzyme activity and slightly decreased the number of TRACP+ multinuclear osteoclasts induced by M-CSF plus RANKL. Ficusin 5-13 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 165-170 30110702-12 2018 CONCLUSIONS: Psoralen and bakuchiol ameliorated M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways activation in vitro. Ficusin 13-21 colony stimulating factor 1 (macrophage) Mus musculus 48-53 30110702-12 2018 CONCLUSIONS: Psoralen and bakuchiol ameliorated M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways activation in vitro. Ficusin 13-21 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 59-64 30110702-12 2018 CONCLUSIONS: Psoralen and bakuchiol ameliorated M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways activation in vitro. Ficusin 13-21 thymoma viral proto-oncogene 1 Mus musculus 138-141 28949389-0 2017 Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/beta-catenin signaling pathway. Ficusin 0-8 cyclin D1 Rattus norvegicus 36-45 29234069-4 2017 Here we report that human NEIL3 cleaves psoralen-induced DNA-DNA cross-links in three-stranded and four-stranded DNA substrates to generate unhooked DNA fragments containing either an abasic site or a psoralen-thymine monoadduct. Ficusin 40-48 nei like DNA glycosylase 3 Homo sapiens 26-31 28982307-6 2017 The PCE constituents, bakuchiol, isobavachalcone, isopsoralen and psoralen, inhibited hTRPC3 currents (inhibited by 40.6 +- 2.7, 27.1 +- 7.9, 35.1 +- 4.8 and 47.4 +- 3.9%, respectively). Ficusin 53-61 transient receptor potential cation channel subfamily C member 3 Homo sapiens 86-92 28982307-9 2017 PCE and its active constituents, bakuchiol, isobavachalcone, isopsoralen and psoralen, caused dose-dependent inhibition of TRPC3 channels, indicating that those ingredients attenuate Phe-induced vasoconstriction. Ficusin 64-72 transient receptor potential cation channel subfamily C member 3 Homo sapiens 123-128 28949389-0 2017 Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/beta-catenin signaling pathway. Ficusin 0-8 Wnt family member 2 Rattus norvegicus 70-73 28949389-0 2017 Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/beta-catenin signaling pathway. Ficusin 0-8 catenin beta 1 Rattus norvegicus 74-86 24551203-0 2014 Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. Ficusin 16-24 erb-b2 receptor tyrosine kinase 2 Homo sapiens 35-40 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 1 Homo sapiens 8-11 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 14 Homo sapiens 13-16 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 8 Homo sapiens 21-24 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 1 Homo sapiens 137-140 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 14 Homo sapiens 154-157 28962172-15 2017 Phospho-ERK, p38 and JNK were markedly increased by psoralen compared with the control group (P<0.05), and the specific inhibitors of ERK (SCH772984), p38 (SB203580) and JNK (SP600125) reversed the stimulatory effects of psoralen on signal marker phosphorylation (P<0.05). Ficusin 52-60 mitogen-activated protein kinase 8 Homo sapiens 173-176 28962172-16 2017 The rate of psoralen-induced cell proliferation was significantly suppressed by inhibitors of ERK, JNK and p38 compared with psoralen treatment alone (P<0.05). Ficusin 12-20 mitogen-activated protein kinase 1 Homo sapiens 94-97 28962172-16 2017 The rate of psoralen-induced cell proliferation was significantly suppressed by inhibitors of ERK, JNK and p38 compared with psoralen treatment alone (P<0.05). Ficusin 12-20 mitogen-activated protein kinase 8 Homo sapiens 99-102 28962172-16 2017 The rate of psoralen-induced cell proliferation was significantly suppressed by inhibitors of ERK, JNK and p38 compared with psoralen treatment alone (P<0.05). Ficusin 12-20 mitogen-activated protein kinase 14 Homo sapiens 107-110 28753523-12 2017 Hence, psoralen and resveratrol co-loaded UDL acts in vitiligo through dual mechanisms of action viz., stimulation of melanin and tyrosinase activity as well as by anti-oxidant activity. Ficusin 7-15 tyrosinase Mus musculus 130-140 28219011-0 2017 Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives. Ficusin 55-63 aldehyde dehydrogenase 8 family member A1 Homo sapiens 18-44 28219011-2 2017 In this study, we further characterized the inhibition of four psoralen and coumarin derivatives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes. Ficusin 63-71 aldehyde dehydrogenase 2 family member Homo sapiens 104-109 27777066-11 2017 Topical application of psoralen liposomal gels on imiquimod induced psoriatic plaque model reduced the symptoms of psoriasis and levels of key psoriatic cytokines such as tumor necrosis factor-alpha, IL-17 and IL-22. Ficusin 23-31 tumor necrosis factor Homo sapiens 171-198 27777066-11 2017 Topical application of psoralen liposomal gels on imiquimod induced psoriatic plaque model reduced the symptoms of psoriasis and levels of key psoriatic cytokines such as tumor necrosis factor-alpha, IL-17 and IL-22. Ficusin 23-31 interleukin 17A Homo sapiens 200-205 27777066-11 2017 Topical application of psoralen liposomal gels on imiquimod induced psoriatic plaque model reduced the symptoms of psoriasis and levels of key psoriatic cytokines such as tumor necrosis factor-alpha, IL-17 and IL-22. Ficusin 23-31 interleukin 22 Homo sapiens 210-215 25869956-0 2015 Psoralen derivatives as inhibitors of NF-kappaB interaction: the critical role of the furan ring. Ficusin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 38-47 24845152-6 2014 These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Ficusin 27-35 caspase 3 Homo sapiens 98-107 24845152-6 2014 These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Ficusin 27-35 tumor protein p53 Homo sapiens 109-112 24845152-6 2014 These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Ficusin 27-35 BCL2 associated X, apoptosis regulator Homo sapiens 114-117 24845152-6 2014 These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Ficusin 27-35 BCL2 apoptosis regulator Homo sapiens 123-128 24703328-7 2014 Based on these results, we believe that psoralen may be feasible for reversing the multidrug resistance by inhibiting ABCB1 gene and protein expression. Ficusin 40-48 ATP binding cassette subfamily B member 1 Homo sapiens 118-123 28825980-4 2017 Among the isolated compounds, 7-O-methylcorylifol A and psoralen exhibited potent inhibition (IC50 values <= 10.89 muM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Ficusin 56-64 latexin Homo sapiens 118-121 28825980-4 2017 Among the isolated compounds, 7-O-methylcorylifol A and psoralen exhibited potent inhibition (IC50 values <= 10.89 muM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Ficusin 56-64 formyl peptide receptor 1 Homo sapiens 252-256 28349059-0 2017 Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. Ficusin 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 71-75 28349059-0 2017 Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. Ficusin 0-8 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 76-80 28349059-0 2017 Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. Ficusin 0-8 mitogen-activated protein kinase 8 Homo sapiens 81-84 28349059-11 2017 Pretreatment by IRE1 agonist tunicamycin or JNK agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Ficusin 92-100 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 16-20 28349059-11 2017 Pretreatment by IRE1 agonist tunicamycin or JNK agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Ficusin 92-100 mitogen-activated protein kinase 8 Homo sapiens 44-47 28349059-12 2017 Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1-ASK1-JNK pathway. Ficusin 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 71-75 28349059-12 2017 Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1-ASK1-JNK pathway. Ficusin 0-8 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 76-80 28349059-12 2017 Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1-ASK1-JNK pathway. Ficusin 0-8 mitogen-activated protein kinase 8 Homo sapiens 81-84 27583569-10 2016 In an in-vitro study, we show that X-PACT induces significant tumor cell apoptosis and cytotoxicity, unlike psoralen or phosphor alone (p<0.0001). Ficusin 108-116 protein kinase, interferon inducible double stranded RNA dependent activator Mus musculus 37-41 27082231-0 2016 Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells. Ficusin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 27082231-6 2016 The ability of psoralen to modulate the transport activity of P-gp in MCF-7/ADR cells was evaluated by measuring the accumulation and efflux of rhodamine 123 (Rh 123) and adriamycin with flow cytometry. Ficusin 15-23 ATP binding cassette subfamily B member 1 Homo sapiens 62-66 27082231-13 2016 Psoralen reduces MDR by inhibiting the efflux function of P-gp, which may be important for increasing the efficiency of chemotherapy and improving the clinical protocols aiming to reverse P-gp-mediated MDR. Ficusin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 58-62 27082231-13 2016 Psoralen reduces MDR by inhibiting the efflux function of P-gp, which may be important for increasing the efficiency of chemotherapy and improving the clinical protocols aiming to reverse P-gp-mediated MDR. Ficusin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 188-192 26335194-0 2015 Psoralen, a mechanism-based inactivator of CYP2B6. Ficusin 0-8 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 43-49 24551203-0 2014 Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. Ficusin 16-24 erb-b2 receptor tyrosine kinase 2 Homo sapiens 75-80 24626199-7 2014 To demonstrate that DNA2 is deleterious to crosslink repair, we used psoralen-induced ICL damage to trigger the repair of a site-specific crosslink in a GFP reporter and observed that "over-resection" can account for reduced repair. Ficusin 69-77 DNA replication helicase/nuclease 2 Homo sapiens 20-24 24871658-9 2014 In vitro study, psoralen significantly suppressed Th2 cytokines of IL-4, IL-5 and IL-13 by ConA-stimulated D10 cells without inhibitory effect on cell viability. Ficusin 16-24 heart and neural crest derivatives expressed 2 Mus musculus 50-53 24871658-9 2014 In vitro study, psoralen significantly suppressed Th2 cytokines of IL-4, IL-5 and IL-13 by ConA-stimulated D10 cells without inhibitory effect on cell viability. Ficusin 16-24 interleukin 4 Rattus norvegicus 67-71 24871658-9 2014 In vitro study, psoralen significantly suppressed Th2 cytokines of IL-4, IL-5 and IL-13 by ConA-stimulated D10 cells without inhibitory effect on cell viability. Ficusin 16-24 interleukin 5 Rattus norvegicus 73-77 24871658-9 2014 In vitro study, psoralen significantly suppressed Th2 cytokines of IL-4, IL-5 and IL-13 by ConA-stimulated D10 cells without inhibitory effect on cell viability. Ficusin 16-24 interleukin 13 Rattus norvegicus 82-87 23715498-0 2013 The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ficusin 41-49 RecQ like helicase 5 Homo sapiens 18-24 23975028-0 2013 Identification and characterization of psoralen and isopsoralen as potent CYP1A2 reversible and time-dependent inhibitors in human and rat preclinical studies. Ficusin 39-47 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 74-80 23975028-1 2013 Naturally occurring furanocoumarin compounds psoralen (PRN) and isopsoralen (IPRN) are bioactive constituents found in herbaceous plants. Ficusin 45-53 cytosolic iron-sulfur assembly component 3 Homo sapiens 55-58 24001377-0 2013 Catechol-O-methyltransferase activity in psoriasis patients treated with psoralen plus ultraviolet A therapy. Ficusin 73-81 catechol-O-methyltransferase Homo sapiens 0-28 22015193-8 2011 CONCLUSION: Combination treatment of osthole, psoralen with aconitine can inhibit cancer cell invasion, which is a result of alteration of the TGF-beta/Smad signaling pathway and down-regulation of NF-kappaB and RANK expressions. Ficusin 46-54 transforming growth factor beta 1 Homo sapiens 143-151 23508956-0 2013 NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks. Ficusin 28-36 nei like DNA glycosylase 1 Homo sapiens 0-5 23508956-2 2013 Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts. Ficusin 245-253 nei like DNA glycosylase 1 Homo sapiens 169-174 23414143-0 2013 Psoralen derivatives as inhibitors of NF-kappaB/DNA interaction: synthesis, molecular modeling, 3D-QSAR, and biological evaluation. Ficusin 0-8 nuclear factor kappa B subunit 1 Homo sapiens 38-47 22015193-8 2011 CONCLUSION: Combination treatment of osthole, psoralen with aconitine can inhibit cancer cell invasion, which is a result of alteration of the TGF-beta/Smad signaling pathway and down-regulation of NF-kappaB and RANK expressions. Ficusin 46-54 SMAD family member 4 Homo sapiens 152-156 21781066-0 2011 CD26/dipeptidyl-peptidase IV and adenosine deaminase serum levels in psoriatic patients treated with cyclosporine, etanercept, and psoralen plus ultraviolet A phototherapy. Ficusin 131-139 dipeptidyl peptidase 4 Homo sapiens 0-28 21781066-1 2011 OBJECTIVE: The aim of this study is to determine serum levels of soluble forms of CD26/dipeptidyl-peptidase IV (DPP-IV) and adenosine deaminase (ADA), thought to be markers of T-cell activation, and changes in their levels in response to cyclosporine, etanercept, and psoralen plus ultraviolet A (PUVA) treatments with respect to disease activity. Ficusin 268-276 dipeptidyl peptidase 4 Homo sapiens 82-110 21781066-1 2011 OBJECTIVE: The aim of this study is to determine serum levels of soluble forms of CD26/dipeptidyl-peptidase IV (DPP-IV) and adenosine deaminase (ADA), thought to be markers of T-cell activation, and changes in their levels in response to cyclosporine, etanercept, and psoralen plus ultraviolet A (PUVA) treatments with respect to disease activity. Ficusin 268-276 dipeptidyl peptidase 4 Homo sapiens 112-118 21781066-1 2011 OBJECTIVE: The aim of this study is to determine serum levels of soluble forms of CD26/dipeptidyl-peptidase IV (DPP-IV) and adenosine deaminase (ADA), thought to be markers of T-cell activation, and changes in their levels in response to cyclosporine, etanercept, and psoralen plus ultraviolet A (PUVA) treatments with respect to disease activity. Ficusin 268-276 adenosine deaminase Homo sapiens 145-148 21781066-0 2011 CD26/dipeptidyl-peptidase IV and adenosine deaminase serum levels in psoriatic patients treated with cyclosporine, etanercept, and psoralen plus ultraviolet A phototherapy. Ficusin 131-139 adenosine deaminase Homo sapiens 33-52 19258314-1 2009 Previously, we have demonstrated that human oxidative DNA glycosylase NEIL1 excises photoactivated psoralen-induced monoadducts but not genuine interstrand cross-links (ICLs) in duplex DNA. Ficusin 99-107 nei like DNA glycosylase 1 Homo sapiens 70-75 20213667-4 2011 After database search and with the aid of docking and molecular dynamics (MD) simulations, a 7H-furo[3,2-g]chromen-7-one derivative and a cyclic peptide were chosen as candidates to be ligands of CMK. Ficusin 93-120 cytidine/uridine monophosphate kinase 1 Homo sapiens 196-199 21285347-2 2011 MSH3, together with MSH2, forms the MutSbeta heteroduplex, which interacts with interstrand cross-links (ICLs) induced by drugs such as cisplatin and psoralen. Ficusin 150-158 mutS homolog 3 Homo sapiens 0-4 21285347-2 2011 MSH3, together with MSH2, forms the MutSbeta heteroduplex, which interacts with interstrand cross-links (ICLs) induced by drugs such as cisplatin and psoralen. Ficusin 150-158 mutS homolog 2 Homo sapiens 20-24 20880231-0 2010 Inhibition of histidine ammonia lyase by 8-methoxypsoralen and psoralen-oxidized photoproducts. Ficusin 50-58 histidine ammonia-lyase Homo sapiens 14-37 19577453-7 2010 Only psoralen and isopsoralen as ERalpha agonists promoted MCF-7 cell proliferation significantly. Ficusin 5-13 estrogen receptor 1 Homo sapiens 33-40 19558552-2 2009 Poikilodermatous MF showing a CD8+ phenotype has been reported to have a nonaggressive clinical behaviour and a good response to psoralen plus ultraviolet A treatment. Ficusin 129-137 CD8a molecule Homo sapiens 30-33 19064630-0 2009 Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Ficusin 0-8 tumor protein p53 Homo sapiens 76-79 19387585-4 2009 The psoralen-induced inhibition of Kv3.1 channels was voltage-dependent, with a steep increase over the voltage range of channel opening. Ficusin 4-12 potassium voltage-gated channel subfamily C member 1 Rattus norvegicus 35-40 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 197-205 tumor protein p53 Homo sapiens 67-70 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 197-205 tumor protein p53 Homo sapiens 265-268 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 310-318 tumor protein p53 Homo sapiens 67-70 18571479-4 2008 Aag(-/-) mouse embryonic stem cells were shown to be more sensitive to the cross-linking agent 4,5",8-trimethylpsoralen than wild-type cells, but no more sensitive than wild-type to the psoralen derivative Angelicin that forms only monoadducts. Ficusin 111-119 N-methylpurine-DNA glycosylase Mus musculus 0-3 18338622-9 2008 Psoralen could also induce the augment of ER-alpha and ER-beta expression in T47D cells significantly. Ficusin 0-8 estrogen receptor 1 Homo sapiens 42-50 18520040-6 2008 Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. Ficusin 13-21 corticotropin releasing hormone Mus musculus 65-95 18435621-1 2008 A triplex-forming oligonucleotide (TFO), HPRT3, conjugated to a psoralen derivative, was designed to target a psoralen reaction site within the HPRT gene. Ficusin 64-72 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 41-45 18338622-9 2008 Psoralen could also induce the augment of ER-alpha and ER-beta expression in T47D cells significantly. Ficusin 0-8 estrogen receptor 2 Homo sapiens 55-62 16259964-5 2005 Without UVA, this psoralen was found to be an effective inhibitor of interferon-gamma (IFN-gamma)-signaling as measured by induction of nitric oxide biosynthesis (IC50 = 0.8 microM). Ficusin 18-26 interferon gamma Mus musculus 69-85 17366735-1 2007 Previously, we found that a furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), blocked a human Kv1.5 potassium channel (hKv1.5) and has a potential antiarrhythmic effect. Ficusin 53-61 potassium voltage-gated channel subfamily A member 5 Homo sapiens 115-120 17366735-1 2007 Previously, we found that a furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), blocked a human Kv1.5 potassium channel (hKv1.5) and has a potential antiarrhythmic effect. Ficusin 53-61 potassium voltage-gated channel subfamily A member 5 Homo sapiens 140-146 17366735-1 2007 Previously, we found that a furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), blocked a human Kv1.5 potassium channel (hKv1.5) and has a potential antiarrhythmic effect. Ficusin 63-96 potassium voltage-gated channel subfamily A member 5 Homo sapiens 115-120 17366735-1 2007 Previously, we found that a furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), blocked a human Kv1.5 potassium channel (hKv1.5) and has a potential antiarrhythmic effect. Ficusin 63-96 potassium voltage-gated channel subfamily A member 5 Homo sapiens 140-146 16678501-2 2006 Following treatment with a psoralen derivative and ultraviolet A radiation doses that produce significant numbers of crosslinks, gamma-H2AX levels in nucleotide excision repair-deficient XP-A fibroblasts (XP12RO-SV) increased to levels that were twice those observed in normal control GM637 fibroblasts. Ficusin 27-35 H2A.X variant histone Homo sapiens 129-139 16678501-4 2006 XP-F fibroblasts (XP2YO-SV and XP3YO) that are also repair-deficient exhibited gamma-H2AX levels below even control fibroblasts following treatment with psoralen and ultraviolet A radiation. Ficusin 153-161 H2A.X variant histone Homo sapiens 79-89 16762476-6 2006 The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor. Ficusin 27-35 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 130-137 16762476-6 2006 The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor. Ficusin 27-35 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 213-220 16259964-5 2005 Without UVA, this psoralen was found to be an effective inhibitor of interferon-gamma (IFN-gamma)-signaling as measured by induction of nitric oxide biosynthesis (IC50 = 0.8 microM). Ficusin 18-26 interferon gamma Mus musculus 87-96 12778626-3 2003 METHODS: Two psoralen-linked triplex-forming oligonucleotides were used to inhibit the expression from a plasmid carrying the rhodopsin and green fluorescent protein fusion gene. Ficusin 13-21 rhodopsin Homo sapiens 126-135 15389192-2 2004 OBJECTIVE: To evaluate the efficacy of combination therapy with bexarotene and psoralen plus ultraviolet A (PUVA) in treating patients with cutaneous T-cell lymphoma (CTCL) that recurred following monotherapy with multiple agents, including electron-beam irradiation, interferon, PUVA, and topical steroids. Ficusin 79-87 TSPY like 2 Homo sapiens 167-171 16225614-0 2005 Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo. Ficusin 72-80 tumor protein p53 Homo sapiens 108-111 16282062-4 2005 The apoptotic rates of K562 cells treated with 40 and 80 microg/ml psoralen for 24 and 48 hours were assayed by Annexin-V-FITC/PI reagent kit on FCM respectively. Ficusin 67-75 annexin A5 Homo sapiens 112-121 15832811-3 2005 We found that psoralen inhibited the hKv1.5 current in a concentration-, use- and voltage-dependent manner with an IC50 value of 180 +/- 21 nM at +60 mV. Ficusin 14-22 potassium voltage-gated channel subfamily A member 5 Homo sapiens 37-43 12746176-4 2003 Psoralens induced mRNAs of the liver enzymes CYP1A1 and UGT1A6, suggesting that enhanced metabolism of estrogens by psoralen treatment may explain the reproductive toxicity and the observed reduction of ovarian follicular function and ovulation. Ficusin 116-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 45-51 12746176-4 2003 Psoralens induced mRNAs of the liver enzymes CYP1A1 and UGT1A6, suggesting that enhanced metabolism of estrogens by psoralen treatment may explain the reproductive toxicity and the observed reduction of ovarian follicular function and ovulation. Ficusin 116-124 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 56-62 12778626-10 2003 CONCLUSION: The authors conclude, that psoralen linked triplex forming oligonucleotides are efficient and specific tools for blocking gene expression from the human rhodopsin gene. Ficusin 39-47 rhodopsin Homo sapiens 165-174 10204021-1 1999 Psoralenes (furocoumarins) in combination with ultraviolet (UV) A radiation (320-400 nm) are used in the treatment of vitiligo, psoriasis, cutaneous T-cell lymphoma and other skin and autoimmune diseases (PUFA therapy). Ficusin 0-10 pumilio RNA binding family member 3 Homo sapiens 205-209 11574688-0 2001 Psoralen-modified clamp-forming antisense oligonucleotides reduce cellular c-Myc protein expression and B16-F0 proliferation. Ficusin 0-8 myelocytomatosis oncogene Mus musculus 77-80 11565743-4 2001 Psoralen-mediated crosslinking experiments suggest that SXL binding to this uridine-rich sequence inhibits recognition of the 5" splice site by U1 snRNP in HeLa nuclear extracts. Ficusin 0-8 Sex lethal Drosophila melanogaster 56-59 11565743-4 2001 Psoralen-mediated crosslinking experiments suggest that SXL binding to this uridine-rich sequence inhibits recognition of the 5" splice site by U1 snRNP in HeLa nuclear extracts. Ficusin 0-8 small ribonucleoprotein particle U1 subunit 70K Drosophila melanogaster 144-152 11169165-1 2001 Psoralen and isopsoralen, furocoumarins isolated from the plant Psoralea corylifolia L., were demonstrated to exhibit in vitro inhibitory actions on monoamine oxidase (MAO) activities in rat brain mitochondria, preferentially inhibiting MAO-A activity over MAO-B activity. Ficusin 0-8 monoamine oxidase A Rattus norvegicus 149-166 11169165-1 2001 Psoralen and isopsoralen, furocoumarins isolated from the plant Psoralea corylifolia L., were demonstrated to exhibit in vitro inhibitory actions on monoamine oxidase (MAO) activities in rat brain mitochondria, preferentially inhibiting MAO-A activity over MAO-B activity. Ficusin 0-8 monoamine oxidase A Rattus norvegicus 168-171 11169165-1 2001 Psoralen and isopsoralen, furocoumarins isolated from the plant Psoralea corylifolia L., were demonstrated to exhibit in vitro inhibitory actions on monoamine oxidase (MAO) activities in rat brain mitochondria, preferentially inhibiting MAO-A activity over MAO-B activity. Ficusin 0-8 monoamine oxidase A Rattus norvegicus 237-242 11169165-1 2001 Psoralen and isopsoralen, furocoumarins isolated from the plant Psoralea corylifolia L., were demonstrated to exhibit in vitro inhibitory actions on monoamine oxidase (MAO) activities in rat brain mitochondria, preferentially inhibiting MAO-A activity over MAO-B activity. Ficusin 0-8 monoamine oxidase B Rattus norvegicus 257-262 11169165-5 2001 Lineweaver-Burk transformation of the inhibition data indicates that inhibition by both psoralen and isopsoralen is non-competitive for MAO-A. Ficusin 88-96 monoamine oxidase A Rattus norvegicus 136-141 11169165-7 2001 On the other hand, inhibition by both psoralen and isopsoralen is competitive for MAO-B. Ficusin 38-46 monoamine oxidase B Rattus norvegicus 82-87 11169165-9 2001 These inhibitory actions of psoralen and isopsoralen on rat brain mitochondrial MAO activities are discussed in relation to their toxicities and their potential applications to treat affective disorders. Ficusin 28-36 monoamine oxidase A Rattus norvegicus 80-83 11079480-0 2000 Effects of glutathione peroxidase and catalase on hemolysis and methemoglobin modifications induced by photooxidized psoralen. Ficusin 117-125 catalase Homo sapiens 38-46 11079480-0 2000 Effects of glutathione peroxidase and catalase on hemolysis and methemoglobin modifications induced by photooxidized psoralen. Ficusin 117-125 hemoglobin subunit gamma 2 Homo sapiens 64-77 10721715-5 2000 Using a psoralen-conjugated TFO designed to bind to a site overlapping with an Oct-1 binding site at the -280 region of the gamma-globin gene, targeted mutagenesis of the Oct-1 binding site has been achieved by transfecting the in-vitro-formed plasmid-oligo complex into human normal fibroblast (NF) cells. Ficusin 8-16 solute carrier family 22 member 1 Homo sapiens 79-84 10721715-5 2000 Using a psoralen-conjugated TFO designed to bind to a site overlapping with an Oct-1 binding site at the -280 region of the gamma-globin gene, targeted mutagenesis of the Oct-1 binding site has been achieved by transfecting the in-vitro-formed plasmid-oligo complex into human normal fibroblast (NF) cells. Ficusin 8-16 hemoglobin subunit gamma 1 Homo sapiens 124-136 10721715-5 2000 Using a psoralen-conjugated TFO designed to bind to a site overlapping with an Oct-1 binding site at the -280 region of the gamma-globin gene, targeted mutagenesis of the Oct-1 binding site has been achieved by transfecting the in-vitro-formed plasmid-oligo complex into human normal fibroblast (NF) cells. Ficusin 8-16 solute carrier family 22 member 1 Homo sapiens 171-176 11738934-7 2001 However, the psoralen analog angelicin (monoadduct damage) induced a significant S-phase delay in the rad14 Delta mutant. Ficusin 13-21 DNA repair protein RAD14 Saccharomyces cerevisiae S288C 102-107 9888801-4 1999 Triplex formation by an oligonucleotide-psoralen conjugate was used to form a covalent photoadduct with a thymine on the nontemplate strand of the HER-2/neu gene. Ficusin 40-48 erb-b2 receptor tyrosine kinase 2 Homo sapiens 147-156 9277151-11 1997 In contrast to previously reported psoralen-induced p53 mutations in mice, the expected psoralen type mutations at alternating AT sites were not detected. Ficusin 35-43 transformation related protein 53, pseudogene Mus musculus 52-55 9745727-2 1998 The same adducts have been isolated from the photoreaction of psoralen with beta-oleoyl-gamma-stearoyl-1-alpha-phosphatidylcholine followed by enzymatic hydrolysis with phospholipase A2. Ficusin 62-70 phospholipase A2 group IB Homo sapiens 169-185 7578089-1 1995 Six nitroxide spin-labeled psoralen derivative have been synthesized and evaluated as probes for structural and dynamic studies. Ficusin 27-35 spindlin 1 Homo sapiens 14-18 8010881-1 1994 Besides coumarin, which up to now has remained the most selective substrate for the coumarin 7-hydroxylase (Coh), 7-ethoxycoumarin, quinoline, 4-methylcoumarin, 7-ethoxy-4-methylcoumarin, 7-ethoxy-4-ethylcoumarin, and psoralen are suitable for this enzyme. Ficusin 218-226 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 84-106 7918236-0 1994 Effects of a new psoralen, 5-geranoxypsoralen, plus UVA radiation on murine ATPase positive Langerhans cells. Ficusin 17-25 dynein, axonemal, heavy chain 8 Mus musculus 76-82 1685031-2 1991 We previously reported that after photoaddition of psoralen derivatives the frequency of HPRT- mutants was significantly lower in FA than in normal human lymphoblasts. Ficusin 51-59 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 89-93 8082160-1 1994 The influence of the DNA repair gene PSO3 on photoactivated psoralen-induced meiotic recombination, gene conversion, reverse mutation, and on survival, was assayed in diploid strains of Saccharomyces cerevisiae homozygous for the wild-type or the pso3-1 mutant allele. Ficusin 60-68 ribonucleotide-diphosphate reductase subunit RNR4 Saccharomyces cerevisiae S288C 37-41 8461033-4 1993 The furanocoumarin derivatives methoxsalen (8-methoxypsoralen) and psoralen proved to be the most potent inhibitors of mouse COH activity (IC50 values 1.0 and 3.1 microM, respectively). Ficusin 53-61 cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus 125-128 1685031-6 1991 In normal cells, the minority of spontaneous (31%) and psoralen-induced mutants (0% and 14% according to treatment) arise from mutations that alter the HPRT gene transcription. Ficusin 55-63 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 152-156 1864010-1 1991 A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Ficusin 282-290 interleukin 2 receptor subunit beta Homo sapiens 42-55 35597499-15 2022 This strategy identified the toxic target, ABL1, and the potential toxic mechanism of psoralen. Ficusin 86-94 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 43-47 1841655-4 1991 Escherichia coli transformed with a plasmid containing the gene for beta-lactamase were used to test a series of oligonucleotides containing psoralen monoadducts after additional exposure to the photoactivating effects of long-wavelength ultraviolet radiation (320-400 nm). Ficusin 141-149 beta-lactamase Escherichia coli 68-82 33602041-0 2021 Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives. Ficusin 70-78 carbonic anhydrase 9 Homo sapiens 24-45 34306204-0 2021 Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF-beta/Smad3 pathway. Ficusin 0-8 transforming growth factor alpha Homo sapiens 110-118 34306204-0 2021 Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF-beta/Smad3 pathway. Ficusin 0-8 SMAD family member 3 Homo sapiens 119-124 34306204-10 2021 Although different concentrations of psoralen enhanced ALP activity and the calcified nodule content in hBMSCs, the enhancement effects were more potent at lower concentrations (0.1, 1 and 10 micromol/l). Ficusin 37-45 alkaline phosphatase, placental Homo sapiens 55-58 34306204-13 2021 In conclusion, psoralen accelerates the osteogenic differentiation of hBMSCs by activating the TGF-beta/Smad3 pathway, which may be valuable for the future clinical treatment of osteoporosis. Ficusin 15-23 transforming growth factor alpha Homo sapiens 95-103 34306204-13 2021 In conclusion, psoralen accelerates the osteogenic differentiation of hBMSCs by activating the TGF-beta/Smad3 pathway, which may be valuable for the future clinical treatment of osteoporosis. Ficusin 15-23 SMAD family member 3 Homo sapiens 104-109 34278468-0 2021 Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin-SN. Ficusin 0-8 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 104-123 34278468-0 2021 Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin-SN. Ficusin 0-8 cystatin SN Homo sapiens 165-176 35462898-9 2022 Psoralen concentration-dependently enhanced both MMP-2 and MMP-9 expression and their activity of HTR-8/SVneo cells. Ficusin 0-8 matrix metallopeptidase 2 Homo sapiens 49-54 35628627-0 2022 Anti-Inflammatory Effects of Psoralen Derivatives on RAW264.7 Cells via Regulation of the NF-kappaB and MAPK Signaling Pathways. Ficusin 29-37 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 90-99 35597499-9 2022 Based on the above experimental results, ABL1 is a potential direct target of psoralen-induced hepatotoxicity. Ficusin 78-86 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 41-45 35597499-13 2022 In summary, we speculated that when psoralen causes hepatotoxicity, it acts on the direct target ABL1, resulting in a decrease in Nrf2 expression, an increase in ROS levels and a reduction in mTOR expression, which may cause cell death. Ficusin 36-44 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 97-101 35597499-13 2022 In summary, we speculated that when psoralen causes hepatotoxicity, it acts on the direct target ABL1, resulting in a decrease in Nrf2 expression, an increase in ROS levels and a reduction in mTOR expression, which may cause cell death. Ficusin 36-44 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 35597499-13 2022 In summary, we speculated that when psoralen causes hepatotoxicity, it acts on the direct target ABL1, resulting in a decrease in Nrf2 expression, an increase in ROS levels and a reduction in mTOR expression, which may cause cell death. Ficusin 36-44 mechanistic target of rapamycin kinase Homo sapiens 192-196 35462898-9 2022 Psoralen concentration-dependently enhanced both MMP-2 and MMP-9 expression and their activity of HTR-8/SVneo cells. Ficusin 0-8 matrix metallopeptidase 9 Homo sapiens 59-64 35462898-12 2022 Thus, our findings suggest that psoralen may serve as a potential repurpose drug candidate that can be used to induce migration and invasion of trophoblast cells through strengthening the NF-kappaB pathway. Ficusin 32-40 nuclear factor kappa B subunit 1 Homo sapiens 188-197 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 17-25 activating transcription factor 6 Homo sapiens 53-58 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 17-25 DNA damage inducible transcript 3 Homo sapiens 63-67 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 17-25 BCL2 apoptosis regulator Homo sapiens 108-113 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 171-179 activating transcription factor 6 Homo sapiens 53-58 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 171-179 DNA damage inducible transcript 3 Homo sapiens 63-67 35257357-13 2022 The treatment of psoralen resulted in an increase in ATF-6 and CHOP protein levels as well as a decrease in Bcl-2 protein level, indicating that cell apoptosis induced by psoralen was associated with ER stress. Ficusin 171-179 BCL2 apoptosis regulator Homo sapiens 108-113 35406631-0 2022 Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Ficusin 0-8 insulin Homo sapiens 52-59 35406631-4 2022 The effects of psoralen on insulin resistance, lipid deposition, the expression and membrane translocation of glucose transporter type 4 (GLUT4), autophagy, and lipogenesis enzymes were determined on sodium oleate-induced L02 cells. Ficusin 15-23 insulin Homo sapiens 27-34 35406631-4 2022 The effects of psoralen on insulin resistance, lipid deposition, the expression and membrane translocation of glucose transporter type 4 (GLUT4), autophagy, and lipogenesis enzymes were determined on sodium oleate-induced L02 cells. Ficusin 15-23 solute carrier family 2 member 4 Homo sapiens 110-136 35406631-4 2022 The effects of psoralen on insulin resistance, lipid deposition, the expression and membrane translocation of glucose transporter type 4 (GLUT4), autophagy, and lipogenesis enzymes were determined on sodium oleate-induced L02 cells. Ficusin 15-23 solute carrier family 2 member 4 Homo sapiens 138-143 35406631-7 2022 Psoralen alleviated insulin resistance in sodium oleate-induced L02 hepatocytes by upregulating the expression and membrane translocation of GLUT4. Ficusin 0-8 insulin Homo sapiens 20-27 35406631-7 2022 Psoralen alleviated insulin resistance in sodium oleate-induced L02 hepatocytes by upregulating the expression and membrane translocation of GLUT4. Ficusin 0-8 solute carrier family 2 member 4 Homo sapiens 141-146 35406631-13 2022 Our study demonstrated that as an antioxidant, psoralen attenuates NAFLD by alleviating insulin resistance and promoting autophagy via AMPK, suggesting psoralen to be a promising candidate for NAFLD. Ficusin 47-55 insulin Homo sapiens 88-95 35406631-13 2022 Our study demonstrated that as an antioxidant, psoralen attenuates NAFLD by alleviating insulin resistance and promoting autophagy via AMPK, suggesting psoralen to be a promising candidate for NAFLD. Ficusin 47-55 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 135-139 35406631-13 2022 Our study demonstrated that as an antioxidant, psoralen attenuates NAFLD by alleviating insulin resistance and promoting autophagy via AMPK, suggesting psoralen to be a promising candidate for NAFLD. Ficusin 152-160 insulin Homo sapiens 88-95 35406631-13 2022 Our study demonstrated that as an antioxidant, psoralen attenuates NAFLD by alleviating insulin resistance and promoting autophagy via AMPK, suggesting psoralen to be a promising candidate for NAFLD. Ficusin 152-160 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 135-139