PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33522985-8 2021 The blaOXA-48 gene was not detected.Well established antimicrobial agents such as colistin, gentamicin and tigecycline and novel antibiotics like ceftazidime/avibactam and eravacycline can be reliable options for the treatment of invasive infections caused by carbapenem-resistant K. pneumoniae. eravacycline 172-184 OXA-48 Klebsiella pneumoniae 4-13 33063176-3 2020 In the concomitant administration with CYP 3A4-inducing drugs, eravacycline dosing should be modified. eravacycline 63-75 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-46 30068997-5 2018 This study identified 67 eravacycline-nonsusceptible isolates; among the extended-spectrum beta-lactamase (ESBL)-positive isolates, eravacycline-nonsusceptible isolates were detected more frequently than tigecycline-nonsusceptible isolates (21.7% vs. 9.4%, p = 0.001). eravacycline 25-37 CTX-M-15 Klebsiella pneumoniae 73-105 30068997-5 2018 This study identified 67 eravacycline-nonsusceptible isolates; among the extended-spectrum beta-lactamase (ESBL)-positive isolates, eravacycline-nonsusceptible isolates were detected more frequently than tigecycline-nonsusceptible isolates (21.7% vs. 9.4%, p = 0.001). eravacycline 132-144 CTX-M-15 Klebsiella pneumoniae 73-105 26863149-1 2016 Eravacycline is an investigational, synthetic fluorocycline antibacterial agent that is structurally similar to tigecycline with two modifications to the D-ring of its tetracycline core: a fluorine atom replaces the dimethylamine moiety at C-7 and a pyrrolidinoacetamido group replaces the 2-tertiary-butyl glycylamido at C-9. eravacycline 0-12 complement component 7 Mus musculus 240-243 26863149-1 2016 Eravacycline is an investigational, synthetic fluorocycline antibacterial agent that is structurally similar to tigecycline with two modifications to the D-ring of its tetracycline core: a fluorine atom replaces the dimethylamine moiety at C-7 and a pyrrolidinoacetamido group replaces the 2-tertiary-butyl glycylamido at C-9. eravacycline 0-12 complement component 9 Mus musculus 322-325