PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 9680514-3 1998 Heptachlor exo-epoxide (a metabolite of heptachlor) and alpha-hexachlorocyclohexane (alpha-HCH) increased from the Chukchi Sea to the pole, and then decreased toward Spitsbergen and Greenland Sea. alpha-hexachlorocyclohexane 85-94 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 123-126 10487416-3 1999 In the current study, we also found that 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) at 1 nM and alpha-HCH isomers at 100 nM could also significantly activate protein tyrosine kinase of Neu immunoprecipitates in a cell-free system. alpha-hexachlorocyclohexane 103-106 erb-b2 receptor tyrosine kinase 2 Homo sapiens 186-189 1370768-7 1992 We have shown that during augmentative hyperplasia caused by the tumor promoters alpha-hexachlorocyclohexane, phenobarbital and ciprofibrate, plasma levels of HGF also increase. alpha-hexachlorocyclohexane 81-108 hepatocyte growth factor Rattus norvegicus 159-162 8015384-4 1994 BBH induced a significant increase in the abundance of both GLUT1 and actin mRNAs, and this effect was dose and time dependent. alpha-hexachlorocyclohexane 0-3 solute carrier family 2 member 1 Bos taurus 60-65 8015384-4 1994 BBH induced a significant increase in the abundance of both GLUT1 and actin mRNAs, and this effect was dose and time dependent. alpha-hexachlorocyclohexane 0-3 actin epsilon 1 Bos taurus 70-75 8015384-7 1994 To determine whether known growth factors cause BBH-like induction of GLUT1 and actin mRNAs, a series of growth factors was also tested. alpha-hexachlorocyclohexane 48-51 solute carrier family 2 member 1 Bos taurus 70-75 8015384-7 1994 To determine whether known growth factors cause BBH-like induction of GLUT1 and actin mRNAs, a series of growth factors was also tested. alpha-hexachlorocyclohexane 48-51 actin epsilon 1 Bos taurus 80-85 8015384-9 1994 Basic FGF had a moderate effect and TNF alpha partially mimicked the effect of BBH on both GLUT1 and actin transcripts. alpha-hexachlorocyclohexane 79-82 tumor necrosis factor Bos taurus 36-45 8015384-9 1994 Basic FGF had a moderate effect and TNF alpha partially mimicked the effect of BBH on both GLUT1 and actin transcripts. alpha-hexachlorocyclohexane 79-82 solute carrier family 2 member 1 Bos taurus 91-96 8015384-9 1994 Basic FGF had a moderate effect and TNF alpha partially mimicked the effect of BBH on both GLUT1 and actin transcripts. alpha-hexachlorocyclohexane 79-82 actin epsilon 1 Bos taurus 101-106 8015384-10 1994 The present data suggests that brain-derived trophic factors present in BBH stimulate BBB-GLUT1 glucose transporter gene expression in ECL cells through a transcriptional mechanism. alpha-hexachlorocyclohexane 72-75 solute carrier family 2 member 1 Bos taurus 90-95 8015384-12 1994 Therefore, BBH may be a useful model to study the characterization of soluble brain-derived trophic factors involved in the induction of BBB-GLUT1 gene expression. alpha-hexachlorocyclohexane 11-14 solute carrier family 2 member 1 Bos taurus 141-146 8210519-5 1993 On the other hand, in Ca(2+)-containing medium the tension evoked by 65 nM ET-1 was no longer sustained in segments preincubated with 200 nM hChs and declined spontaneously to 76 +/- 12% (n = 6) of maximal tension after 6 min. alpha-hexachlorocyclohexane 141-145 endothelin 1 Homo sapiens 75-79 2479123-1 1989 The effects of the beta-isomer of hexachlorocyclohexane (beta-HCH) on the induction of the cytosolic progesterone receptor (PgRc), on the redistribution of the estrogen receptor (ER), and its affinity for ER were investigated in the estrogen-sensitive human mammary tumor cell line MCF-7. alpha-hexachlorocyclohexane 57-65 progesterone receptor Homo sapiens 101-122 2054651-3 1991 CaM antagonists, including trifluoperazine (TFP), W-5, W-7, promethazine and haloperidol, dose-dependently inhibited potassium depolarization-stimulated [3H]HCh-3 binding with IC50s of 20, 40, 70, 30 and 48 (microM), respectively. alpha-hexachlorocyclohexane 157-160 calmodulin 1 Rattus norvegicus 0-3 35477935-4 2022 A joint X-ray/neutron structure of the Mpro/BBH-1 complex demonstrates that a Cys145 thiolate reaction with the inhibitor"s keto-warhead creates a negatively charged oxyanion. alpha-hexachlorocyclohexane 44-47 NEWENTRY Severe acute respiratory syndrome-related coronavirus 39-43 2479123-1 1989 The effects of the beta-isomer of hexachlorocyclohexane (beta-HCH) on the induction of the cytosolic progesterone receptor (PgRc), on the redistribution of the estrogen receptor (ER), and its affinity for ER were investigated in the estrogen-sensitive human mammary tumor cell line MCF-7. alpha-hexachlorocyclohexane 57-65 progesterone receptor Homo sapiens 124-128 2479123-3 1989 beta-HCH in concentrations higher than 1 microM caused induction of PgRc whereas TCP was essentially without effect up to a cytotoxic concentration of 100 microM. alpha-hexachlorocyclohexane 0-8 progesterone receptor Homo sapiens 68-72 2732947-1 1989 Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H]hemicholinium-3 ([ 3H]HCh-3) and the uptake of [3H]choline. alpha-hexachlorocyclohexane 200-203 phospholipase A2 group IB Homo sapiens 0-16 2732947-1 1989 Phospholipase A2 (PLA2) treatment has been shown previously to stimulate the sodium-dependent high-affinity choline uptake system as assessed by both the specific binding of [3H]hemicholinium-3 ([ 3H]HCh-3) and the uptake of [3H]choline. alpha-hexachlorocyclohexane 200-203 phospholipase A2 group IB Homo sapiens 18-22 2732947-7 1989 After PLA2 treatment, [3H]HCh-3 binding was increased about 2.5-fold over basal levels in different regions of the brain. alpha-hexachlorocyclohexane 26-29 phospholipase A2 group IB Homo sapiens 6-10 2732947-2 1989 In the present study, the specificity of PLA2-induced stimulation upon [3H]HCh-3 binding has been examined. alpha-hexachlorocyclohexane 75-78 phospholipase A2 group IB Homo sapiens 41-45 2732947-9 1989 Residual [3H]HCh-3 binding in the denervated hippocampus and lesioned striatum was increased by PLA2 treatment but remained lower than that in PLA2-treated controls. alpha-hexachlorocyclohexane 13-16 phospholipase A2 group IB Homo sapiens 96-100 2732947-3 1989 PLA2, as well as phospholipase C (PLC), treatment of synaptic membranes produced a dose-dependent increase in the specific binding of [3H]HCh-3 whereas neither phospholipase B nor phospholipase D had any effect. alpha-hexachlorocyclohexane 138-141 phospholipase A2 group IB Homo sapiens 0-4 6209737-5 1984 Fasting has an additive effect on the increase of cytochrome P-450 level in the alpha-HCH treated rats. alpha-hexachlorocyclohexane 80-89 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 50-66 3196359-2 1988 Incubation of striatal synaptic membranes with bee venom PLA2 resulted in a concentration-dependent increase in the specific binding of [3H]HCh-3. alpha-hexachlorocyclohexane 140-143 phospholipase A2 group IB Homo sapiens 57-61 3196359-7 1988 However, higher concentrations of PLA2, which further increased the specific binding of [3H]HCh-3, caused a reduction of [3H]choline uptake, apparently due to disruption of synaptosomal integrity by PLA2. alpha-hexachlorocyclohexane 92-95 phospholipase A2 group IB Homo sapiens 34-38 3196359-8 1988 Finally, potassium depolarization- and PLA2-induced increases in specific [3H]HCh-3 binding were not additive. alpha-hexachlorocyclohexane 78-81 phospholipase A2 group IB Homo sapiens 39-43 2873904-6 1986 PB or alpha-HCH treatment further decreased expression of L-PK in foci, but not in normal liver. alpha-hexachlorocyclohexane 6-15 pyruvate kinase L/R Rattus norvegicus 58-62 57836-0 1976 The biosynthesis of cytidine nucleotides and the level of cytochrome P-450 in rat liver after administration of alpha-hexachlorocyclohexane. alpha-hexachlorocyclohexane 112-139 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 58-74 6601061-7 1983 The K100-HCH conjugate was more immunogenic than the K100-TT conjugate and elicited anti-Hib responses similar to the Hib conjugates after the third injection. alpha-hexachlorocyclohexane 9-12 C1q-like 3 Mus musculus 4-8 6163436-0 1981 The elevation of rat liver glutathione-S-transferase activity by alpha-hexachlorocyclohexane. alpha-hexachlorocyclohexane 65-92 hematopoietic prostaglandin D synthase Rattus norvegicus 27-52 6159389-0 1980 Contamination of bovine milk with DDT and HCH residues in relation to their usage in malaria control programme. alpha-hexachlorocyclohexane 42-45 Weaning weight-maternal milk Bos taurus 24-28 6159389-1 1980 The contribution of spraying DDT and HCH for malaria control towards the contamination of bovine milk was investigated by analysing milk samples collected from preselected localities sprayed with either DDT or HCH in the Punjab. alpha-hexachlorocyclohexane 37-40 Weaning weight-maternal milk Bos taurus 97-101 6159389-3 1980 It is considered that these results may have significant bearing on the regulatory control of DDT and HCH residues in milk. alpha-hexachlorocyclohexane 102-105 Weaning weight-maternal milk Bos taurus 118-122 81544-0 1978 The biosynthesis of pyrimidine nucleotides and cytochrome P-450 content in rat liver microsomes after the administration of alpha-hexachlorocyclohexane (in vivo study). alpha-hexachlorocyclohexane 124-151 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 47-63 6188322-5 1983 Activities of delta 5 3 beta hydroxysteroid dehydrogenase (delta 5 3 beta HSDH), 17 beta hydroxysteroid dehydrogenase (17 beta HSDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding. alpha-hexachlorocyclohexane 318-321 glucose-6-phosphate dehydrogenase Rattus norvegicus 137-170 6188322-5 1983 Activities of delta 5 3 beta hydroxysteroid dehydrogenase (delta 5 3 beta HSDH), 17 beta hydroxysteroid dehydrogenase (17 beta HSDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding. alpha-hexachlorocyclohexane 318-321 glucose-6-phosphate dehydrogenase Rattus norvegicus 172-179 77193-0 1978 Liver growth, biosynthesis of cytidine nucleotides and level of cytochrome P-450 in rat liver after administration of alpha-hexachlorocyclohexane. alpha-hexachlorocyclohexane 118-145 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 64-80 77193-1 1978 The biosynthesis of cytidine nucleotides and the level of microsomal cytochrome P-450 in intact and regenerating rat liver after repeated administration of alpha-hexachlorocyclohexane (alpha-HCH) were compared. alpha-hexachlorocyclohexane 156-183 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 69-85 77193-1 1978 The biosynthesis of cytidine nucleotides and the level of microsomal cytochrome P-450 in intact and regenerating rat liver after repeated administration of alpha-hexachlorocyclohexane (alpha-HCH) were compared. alpha-hexachlorocyclohexane 185-194 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 69-85 32147343-2 2020 In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY. alpha-hexachlorocyclohexane 14-17 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 58-65 1187696-4 1975 In PMS-hCH saline-treated control animals, prolactin levels had dropped by 15 and 30 min when compared with the zero-time values but by 60 min had increased significantly above the 30-min level. alpha-hexachlorocyclohexane 7-10 prolactin Rattus norvegicus 43-52 33069077-5 2020 Furthermore, BBH showed asignificant anti-inflammatory effect through regulating activities of SOD, MPOandexpressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in colontissue. alpha-hexachlorocyclohexane 13-16 tumor necrosis factor Homo sapiens 149-158 33069077-5 2020 Furthermore, BBH showed asignificant anti-inflammatory effect through regulating activities of SOD, MPOandexpressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in colontissue. alpha-hexachlorocyclohexane 13-16 interleukin 1 alpha Homo sapiens 160-168 33069077-5 2020 Furthermore, BBH showed asignificant anti-inflammatory effect through regulating activities of SOD, MPOandexpressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in colontissue. alpha-hexachlorocyclohexane 13-16 interleukin 6 Homo sapiens 173-177 32714312-9 2020 The vacuolar calcium channel gene YVC1 was upregulated, while the vacuolar calcium pump gene PMC1 was downregulated in the BBH + FLC and BBH alone groups. alpha-hexachlorocyclohexane 123-126 calcium-transporting ATPase PMC1 Saccharomyces cerevisiae S288C 93-97 32714312-9 2020 The vacuolar calcium channel gene YVC1 was upregulated, while the vacuolar calcium pump gene PMC1 was downregulated in the BBH + FLC and BBH alone groups. alpha-hexachlorocyclohexane 137-140 calcium-transporting ATPase PMC1 Saccharomyces cerevisiae S288C 93-97 32147343-2 2020 In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY. alpha-hexachlorocyclohexane 14-17 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 116-123 32147343-2 2020 In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY. alpha-hexachlorocyclohexane 112-115 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 58-65 32147343-2 2020 In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY. alpha-hexachlorocyclohexane 112-115 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 116-123 31679470-8 2020 Finally, CO poisoning increased the mRNA and protein levels of Nrf2 and downstream genes, and HCH further induced the anti-oxidative capability.Conclusion: These findings indicate the neuroprotective effects of HCH on DEACMP, which are related to the activation of Nrf2 signaling pathway. alpha-hexachlorocyclohexane 94-97 NFE2 like bZIP transcription factor 2 Rattus norvegicus 265-269 31679470-6 2020 Additionally, the mRNA and protein expression levels of Nrf2 and downstream genes were detected by RT-PCR and Western blotting, respectively.Results: Our results showed that CO poisoning significantly impaired neurological function which was improved over time, and HCH markedly attenuated neurological impairment following CO poisoning. alpha-hexachlorocyclohexane 266-269 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-60 31679470-8 2020 Finally, CO poisoning increased the mRNA and protein levels of Nrf2 and downstream genes, and HCH further induced the anti-oxidative capability.Conclusion: These findings indicate the neuroprotective effects of HCH on DEACMP, which are related to the activation of Nrf2 signaling pathway. alpha-hexachlorocyclohexane 211-214 NFE2 like bZIP transcription factor 2 Rattus norvegicus 63-67 31679470-8 2020 Finally, CO poisoning increased the mRNA and protein levels of Nrf2 and downstream genes, and HCH further induced the anti-oxidative capability.Conclusion: These findings indicate the neuroprotective effects of HCH on DEACMP, which are related to the activation of Nrf2 signaling pathway. alpha-hexachlorocyclohexane 211-214 NFE2 like bZIP transcription factor 2 Rattus norvegicus 265-269 32289106-12 2018 Decreased ADG increased days to achieve harvest BW, by 10 and 15 d in the MCh and HCh treatments compared with LCh, respectively (P < 0.001). alpha-hexachlorocyclohexane 82-85 ADG Sus scrofa 10-13 29631365-4 2018 HCh-mediated dye uptake was inhibited by SRPTEKT- Hdc with similar efficacy. alpha-hexachlorocyclohexane 0-3 histidine decarboxylase Oryctolagus cuniculus 50-53 29631365-8 2018 In summary, our results show that SRPTEKT- Hdc blocked HCh function and intercellular Ca2+ signaling at concentrations that minimally affected dye coupling. alpha-hexachlorocyclohexane 55-58 histidine decarboxylase Oryctolagus cuniculus 43-46 29735922-8 2018 In addition, &Sigma;HCH including &beta;-HCH and &gamma;-HCH was correlated with annual family income and gravidity as well as cow milk and beef consumptions. alpha-hexachlorocyclohexane 24-27 Weaning weight-maternal milk Bos taurus 143-147 30036966-4 2018 Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by beta-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. alpha-hexachlorocyclohexane 190-198 signal transducer and activator of transcription 3 Homo sapiens 56-106 30036966-4 2018 Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by beta-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. alpha-hexachlorocyclohexane 190-198 signal transducer and activator of transcription 3 Homo sapiens 108-113 30036966-7 2018 RESULTS AND CONCLUSIONS: The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to beta-HCH. alpha-hexachlorocyclohexane 169-177 signal transducer and activator of transcription 3 Homo sapiens 92-97 29093541-1 2017 The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). alpha-hexachlorocyclohexane 101-104 thymoma viral proto-oncogene 1 Mus musculus 35-39 29093541-8 2017 HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. alpha-hexachlorocyclohexane 0-3 thymoma viral proto-oncogene 1 Mus musculus 39-43 29093541-8 2017 HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. alpha-hexachlorocyclohexane 97-100 thymoma viral proto-oncogene 1 Mus musculus 39-43 29093541-8 2017 HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. alpha-hexachlorocyclohexane 97-100 thymoma viral proto-oncogene 1 Mus musculus 62-66 29093541-9 2017 Our findings reveal that HCH may exert cardioprotective effects through a PI3K-Akt1-dependent mechanism. alpha-hexachlorocyclohexane 25-28 thymoma viral proto-oncogene 1 Mus musculus 79-83 26775070-7 2016 The inhibitory effects of HCh on the AngII mediated responses were also observed in genetically-induced HCh (ApoE-deficient mice). alpha-hexachlorocyclohexane 26-29 apolipoprotein E Mus musculus 109-113 27535021-4 2016 However, the protective effects of BBH against H2 O2 -induced ROS generation and cell growth reduction were abolished by an HO-1 inhibitor. alpha-hexachlorocyclohexane 35-38 heme oxygenase 1 Mus musculus 124-128 27535021-5 2016 Moreover, BBH-mediated induction and activation of HO-1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA). alpha-hexachlorocyclohexane 10-13 heme oxygenase 1 Mus musculus 51-55 27535021-5 2016 Moreover, BBH-mediated induction and activation of HO-1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA). alpha-hexachlorocyclohexane 10-13 nuclear factor, erythroid derived 2, like 2 Mus musculus 93-97 27535021-6 2016 In addition, the effects of BBH against H2 O2 -induced ROS accumulation and growth inhibition were abrogated in C2C12 cells transfected with Nrf2 siRNA. alpha-hexachlorocyclohexane 28-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 27535021-7 2016 Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress-induced injury and this effect involved activation of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane 47-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 27535021-7 2016 Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress-induced injury and this effect involved activation of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane 47-50 heme oxygenase 1 Mus musculus 165-169 27535021-1 2016 Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane 106-109 nuclear factor, erythroid derived 2, like 2 Mus musculus 360-364 27535021-1 2016 Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane 106-109 heme oxygenase 1 Mus musculus 365-369 26775070-7 2016 The inhibitory effects of HCh on the AngII mediated responses were also observed in genetically-induced HCh (ApoE-deficient mice). alpha-hexachlorocyclohexane 104-107 apolipoprotein E Mus musculus 109-113 26775070-9 2016 CONCLUSIONS: These findings indicate that HCh blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation. alpha-hexachlorocyclohexane 42-45 serine (or cysteine) peptidase inhibitor, clade B, member 9d Mus musculus 178-181 26688241-6 2016 Moreover, the evaluation on the changes of metabolic enzymes revealed that HBCD and alpha-HCH shared a similar pattern of cytochrome P450 induction (CYP2B6), which was different from those of PCBs and BDE47 (CYP1A1 and CYP2B6). alpha-hexachlorocyclohexane 84-93 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 149-155 26688241-6 2016 Moreover, the evaluation on the changes of metabolic enzymes revealed that HBCD and alpha-HCH shared a similar pattern of cytochrome P450 induction (CYP2B6), which was different from those of PCBs and BDE47 (CYP1A1 and CYP2B6). alpha-hexachlorocyclohexane 84-93 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 219-225 26688241-7 2016 These results indicated that low concentrations of HBCD could induce "adaptive responses" to the subsequent treatment with high concentrations of HBCD/alpha-HCH in L02 cells, which was associated with the PI3K/Akt pathway, and AMPK and p38 MAPK signaling. alpha-hexachlorocyclohexane 151-160 AKT serine/threonine kinase 1 Homo sapiens 210-213 26688241-7 2016 These results indicated that low concentrations of HBCD could induce "adaptive responses" to the subsequent treatment with high concentrations of HBCD/alpha-HCH in L02 cells, which was associated with the PI3K/Akt pathway, and AMPK and p38 MAPK signaling. alpha-hexachlorocyclohexane 151-160 mitogen-activated protein kinase 14 Homo sapiens 236-239 23658018-6 2013 Truncations of the intracellular C-terminal tail and an AAA substitution of the putative metal-binding HCH C-terminal tripeptide (thought to be required for transport) also exhibited elevated transport rates and Km values when compared with WT hCTR1. alpha-hexachlorocyclohexane 103-106 solute carrier family 31 member 1 Homo sapiens 244-249 26205368-3 2015 The major differences between CTR1 and CTR2 are that CTR1 contains a HIS/MET-rich domain N-terminal of the METS that participate in the first two stacked rings that form the pore, and a longer C-terminal tail that includes a Cu binding HIS-CYS-HIS (HCH) motif right at the end. alpha-hexachlorocyclohexane 249-252 solute carrier family 31 member 1 Homo sapiens 53-57 26000275-5 2015 Moreover, ATP increases the plasma membrane permeability to small molecules and a non-selective membrane current, both of which were inhibited by Cx HCh/Panx1Ch blockers. alpha-hexachlorocyclohexane 149-152 pannexin 1 Mus musculus 153-158 24837030-6 2014 This study also shows that the last three amino acids of the CTR1 c-terminal domain, HCH, are important for maintaining the crystal structure of the Atox1, allowing less structural flexibility and improved thermal stability of Atox1. alpha-hexachlorocyclohexane 85-88 solute carrier family 31 member 1 Homo sapiens 61-65 24837030-6 2014 This study also shows that the last three amino acids of the CTR1 c-terminal domain, HCH, are important for maintaining the crystal structure of the Atox1, allowing less structural flexibility and improved thermal stability of Atox1. alpha-hexachlorocyclohexane 85-88 antioxidant 1 copper chaperone Homo sapiens 149-154 24837030-6 2014 This study also shows that the last three amino acids of the CTR1 c-terminal domain, HCH, are important for maintaining the crystal structure of the Atox1, allowing less structural flexibility and improved thermal stability of Atox1. alpha-hexachlorocyclohexane 85-88 antioxidant 1 copper chaperone Homo sapiens 227-232 24216264-9 2014 Blood levels of HCH, endosulfan and total pesticides were significantly higher in CKD patients and negatively correlated with eGFR. alpha-hexachlorocyclohexane 16-19 epidermal growth factor receptor Homo sapiens 126-130 24183627-2 2014 A concurrent increase of the DDT and HCH concentrations from the late 1980s in Lake Yamzho Yumco, Nam Co and Star Sea were observed. alpha-hexachlorocyclohexane 37-40 SH3 and cysteine rich domain 3 Homo sapiens 98-101 23349669-4 2013 PRINCIPAL FINDINGS: Our results revealed that all the HCHs not only stimulated the activities of catalase (CAT) and peroxidase (POD), but also inhibited the activity of superoxide dismutase (SOD). alpha-hexachlorocyclohexane 54-58 catalase 2 Arabidopsis thaliana 97-105 24240585-10 2013 Multiple regression analysis revealed a significant interaction between beta-HCH and GSTM1<formula>^{-}</formula> genotype (p< 0.05) as well as in beta-HCH and GSTT1<formula>^{-}</formula> genotype (p< 0.05) respectively. alpha-hexachlorocyclohexane 72-80 glutathione S-transferase mu 1 Homo sapiens 85-90 24240585-10 2013 Multiple regression analysis revealed a significant interaction between beta-HCH and GSTM1<formula>^{-}</formula> genotype (p< 0.05) as well as in beta-HCH and GSTT1<formula>^{-}</formula> genotype (p< 0.05) respectively. alpha-hexachlorocyclohexane 72-80 glutathione S-transferase theta 1 Homo sapiens 175-180 22949524-7 2013 A significant association was seen between beta-HCH and GSTM1 genotype when interaction between GSTM1 gene polymorphism, maternal blood OCP levels and period of gestation (POG) was ascertained. alpha-hexachlorocyclohexane 43-51 glutathione S-transferase mu 1 Homo sapiens 56-61 22949524-7 2013 A significant association was seen between beta-HCH and GSTM1 genotype when interaction between GSTM1 gene polymorphism, maternal blood OCP levels and period of gestation (POG) was ascertained. alpha-hexachlorocyclohexane 43-51 glutathione S-transferase mu 1 Homo sapiens 96-101 23349669-4 2013 PRINCIPAL FINDINGS: Our results revealed that all the HCHs not only stimulated the activities of catalase (CAT) and peroxidase (POD), but also inhibited the activity of superoxide dismutase (SOD). alpha-hexachlorocyclohexane 54-58 catalase 2 Arabidopsis thaliana 107-110 23349669-4 2013 PRINCIPAL FINDINGS: Our results revealed that all the HCHs not only stimulated the activities of catalase (CAT) and peroxidase (POD), but also inhibited the activity of superoxide dismutase (SOD). alpha-hexachlorocyclohexane 54-58 peroxidase Arabidopsis thaliana 116-126 23349669-4 2013 PRINCIPAL FINDINGS: Our results revealed that all the HCHs not only stimulated the activities of catalase (CAT) and peroxidase (POD), but also inhibited the activity of superoxide dismutase (SOD). alpha-hexachlorocyclohexane 54-58 peroxidase Arabidopsis thaliana 128-131 21962538-4 2012 There was no direct effect of alpha-HCH on AR but both isomers significantly suppressed the activity of AR in co-exposure with the natural ligand dihydrotestosterone in a concentration-dependent manner. alpha-hexachlorocyclohexane 30-39 androgen receptor Homo sapiens 104-106 22766289-3 2012 The amperometric response showed a linear dependence on the concentration of HCH with the detection limit of 0.06 muM. alpha-hexachlorocyclohexane 77-80 latexin Homo sapiens 114-117 21962538-0 2012 Enantioselective effects of alpha-hexachlorocyclohexane (HCH) isomers on androgen receptor activity in vitro. alpha-hexachlorocyclohexane 28-55 androgen receptor Homo sapiens 73-90 21962538-6 2012 Although studies with other pesticides demonstrated strong enantioselective differences in toxicity, the present research shows rather minor differences in modulations of AR by both alpha-HCH enantiomers. alpha-hexachlorocyclohexane 182-191 androgen receptor Homo sapiens 171-173 21962538-0 2012 Enantioselective effects of alpha-hexachlorocyclohexane (HCH) isomers on androgen receptor activity in vitro. alpha-hexachlorocyclohexane 57-60 androgen receptor Homo sapiens 73-90 21962538-7 2012 For the first time, enantioselective effects of alpha-HCH were demonstrated and the results suggest interaction with multiple regulatory events controlling the AR activity. alpha-hexachlorocyclohexane 48-57 androgen receptor Homo sapiens 160-162 20143817-2 2010 In this study, the enantioselective behavior of alpha-HCH in mice (CD1) and quail (Coturnix japonica) was investigated and compared after a single dose of exposure. alpha-hexachlorocyclohexane 48-57 CD1 antigen complex Mus musculus 67-70 20735721-9 2010 FVIII bound to Glu-Gly-Arg-active-site-modified FVIIa (K(d), ~0.8 nM) with a higher affinity for the HCh than for the LCh (K(d), 5.9 and 18.9 nm). alpha-hexachlorocyclohexane 101-104 coagulation factor VIII Homo sapiens 0-5 21872331-2 2011 Levels of total HCHs ( HCH) and total DDTs ( DDT) in water detected by GC-ECD ranged from 0.85 to 12.77 ng L-1 and from 3.54 to 33.59 ng L-1, respectively. alpha-hexachlorocyclohexane 16-20 immunoglobulin kappa variable 1-16 Homo sapiens 107-110 21484269-9 2011 Contribution analysis showed that dibenz[a,h]anthracene contributed most to the carcinogenic risk in XZ city, and alpha-HCH, beta-HCH and gamma-HCH posed the most carcinogenic risk in tap water from GoHu (GH) in Eastern Taihu Lake. alpha-hexachlorocyclohexane 114-123 nuclear RNA export factor 1 Homo sapiens 184-187 20303568-2 2010 Application of zerovalent iron (Fe(0)) was investigated to accelerate the degradation of HCHs (alpha-, beta-, gamma- and delta-hexachlorocyclohexane) and DDX (DDT, DDE and DDD) in the soil from a former organochlorine pesticide manufacturing plant. alpha-hexachlorocyclohexane 89-93 aldo-keto reductase family 1 member C3 Homo sapiens 95-157 19154159-2 2009 The selectivity has been achieved by combining antibodies raised against 5-[6-(4-aminobenzenesulfonylamino)pyridin-3-yl]-2-methylpentanoic acid (SA1), covalently coupled to horseshoe crab hemocyanin (HCH), and 5-[4-(amino)phenylsulfonamide]-5-oxopentanoic acid (SA2), coupled to ovalbumin (OVA), on an indirect ELISA format. alpha-hexachlorocyclohexane 200-203 stromal antigen 1 Homo sapiens 145-148 18940228-3 2009 Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase. alpha-hexachlorocyclohexane 22-25 catalase Rattus norvegicus 190-198 18940228-3 2009 Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase. alpha-hexachlorocyclohexane 22-25 glucose-6-phosphate dehydrogenase Rattus norvegicus 203-236 18940228-6 2009 Prefeeding of ajwain extract at 1% level to rats injected with HCH reverted the significant changes in catalase, G-6-PDH, GST and -glutamyl transpeptidase. alpha-hexachlorocyclohexane 63-66 catalase Rattus norvegicus 103-111 18940228-6 2009 Prefeeding of ajwain extract at 1% level to rats injected with HCH reverted the significant changes in catalase, G-6-PDH, GST and -glutamyl transpeptidase. alpha-hexachlorocyclohexane 63-66 hematopoietic prostaglandin D synthase Rattus norvegicus 122-125 18828386-3 2008 All these results indicated that BHC-A-mpd was a promising GEM in bioremediation of MP and HCH co-contaminated environment. alpha-hexachlorocyclohexane 91-94 mevalonate diphosphate decarboxylase Homo sapiens 39-42 17573532-6 2007 Positional cloning of bbh reveals a hypomorphic mutation in betaPix, a binding partner for the p21-activated kinase (Pak) and a guanine nucleotide exchange factor for Rac and Cdc42. alpha-hexachlorocyclohexane 22-25 cell division cycle 42 Danio rerio 175-180 17132731-4 2006 The HCCH motif is involved in stabilizing the Vif-Cullin 5 interaction, but the exact role of the conserved His and Cys residues remains elusive. alpha-hexachlorocyclohexane 4-8 cullin 5 Homo sapiens 50-58 16246485-3 2006 The highest concentration of alpha-BHC significantly increased the number and area of glutathione S-transferase placental form (GST-P) positive foci, preneoplastic lesions in the liver, but its low dose, 0.05 ppm, caused significant reduction, showing a J-shape dose-response curve. alpha-hexachlorocyclohexane 29-38 glutathione S-transferase pi 1 Rattus norvegicus 86-133 14667721-0 2004 Air-sea gas exchange of HCHs and PCBs and enantiomers of alpha-HCH in the Kattegat Sea region. alpha-hexachlorocyclohexane 57-66 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 4-7 16636053-5 2006 The HCCH zinc coordination site, which is conserved among primate lentivirus Vif proteins, does not correspond to any known class of zinc-binding motif. alpha-hexachlorocyclohexane 4-8 Vif Human immunodeficiency virus 1 77-80 16636053-6 2006 Mutations of His/Cys residues in the HCCH motif impair zinc coordination, Cul5 binding, and APOBEC3G degradation. alpha-hexachlorocyclohexane 37-41 cullin 5 Homo sapiens 74-78 16636053-6 2006 Mutations of His/Cys residues in the HCCH motif impair zinc coordination, Cul5 binding, and APOBEC3G degradation. alpha-hexachlorocyclohexane 37-41 apolipoprotein B mRNA editing enzyme catalytic subunit 3G Homo sapiens 92-100 16636053-10 2006 We propose that the HCCH zinc-binding motif facilitates Vif-Cul5 binding by playing a structural role in positioning hydrophobic residues for direct contact with Cul5. alpha-hexachlorocyclohexane 20-24 Vif Human immunodeficiency virus 1 56-59 16636053-10 2006 We propose that the HCCH zinc-binding motif facilitates Vif-Cul5 binding by playing a structural role in positioning hydrophobic residues for direct contact with Cul5. alpha-hexachlorocyclohexane 20-24 cullin 5 Homo sapiens 60-64 16636053-10 2006 We propose that the HCCH zinc-binding motif facilitates Vif-Cul5 binding by playing a structural role in positioning hydrophobic residues for direct contact with Cul5. alpha-hexachlorocyclohexane 20-24 cullin 5 Homo sapiens 162-166 15788193-7 2005 Among the isomers and metabolites of HCH, DDT and PCB, alpha-HCH, pp"-DDT and PCB (101), PCB (118), PCB(153) and PCB (138) were found to be dominant. alpha-hexachlorocyclohexane 55-64 pyruvate carboxylase Homo sapiens 50-53 14667721-0 2004 Air-sea gas exchange of HCHs and PCBs and enantiomers of alpha-HCH in the Kattegat Sea region. alpha-hexachlorocyclohexane 57-66 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 83-86 10480230-6 1999 The finding that Kd of LCh binding to vWf (3.8 nM) is 9.5 times higher than that of fVIII (0.4 nM), indicates that the heavy chain (HCh) is required for the maximal affinity of fVIII for vWf. alpha-hexachlorocyclohexane 132-135 von Willebrand factor Homo sapiens 38-41 11482646-0 2001 Seasonal dependence of the chiral composition of alpha-HCH in coastal deposition at the North Sea. alpha-hexachlorocyclohexane 49-58 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 0-3 11482646-1 2001 The environmental pollutant alpha-HCH was analysed in seawater, air and bulk deposition samples from the North Sea. alpha-hexachlorocyclohexane 28-37 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 111-114 10605949-9 1999 Only vWF large proteolytic N-terminal homodimeric fragment SPIII (vWF residues 1-1365), but not small monomeric N-terminal fragment SPIII-T4 (1-272), both of which are known to contain a major fVIII binding site, was able to support reconstitution of fVIII activity from isolated LCh and HCh subunits in the presence of Mn2+ or Ca2+. alpha-hexachlorocyclohexane 288-291 von Willebrand factor Homo sapiens 5-8 11917986-2 2002 The atmosphere is found to effectively distribute the HCHs within the Baltic Sea environment and beyond, resulting in relatively uniform concentrations in environmental compartments that do not directly receive emissions. alpha-hexachlorocyclohexane 54-58 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 77-80 10605949-2 1999 We examined the effect of vWF on kinetic parameters for interaction between LCh and HCh in the presence of Ca2+ and Mn2+ ions, the most effective mediators of fVIII reconstitution from isolated subunits, and determined the minimal structural portion of vWF able to enhance fVIII formation. alpha-hexachlorocyclohexane 84-87 von Willebrand factor Homo sapiens 26-29 10605949-3 1999 We found that affinity (Kd) for LCh/HCh binding mediated by Ca2+ and Mn2+ was 91 and 34.9 nM in the absence of vWF and 15.5 and 5.6 nM in its presence. alpha-hexachlorocyclohexane 36-39 von Willebrand factor Homo sapiens 111-114 10605949-5 1999 The value of the dissociation rate constant (k(off)) for LCh/HCh complex was lower in the presence of Mn2+ (k(off) 4.6x 10(-6) s(-1)) than Ca2+ (k(off) 8.4 x 10(-6) s(-1)) but in both cases vWF had no effect on k(off). alpha-hexachlorocyclohexane 61-64 von Willebrand factor Homo sapiens 190-193 10480230-6 1999 The finding that Kd of LCh binding to vWf (3.8 nM) is 9.5 times higher than that of fVIII (0.4 nM), indicates that the heavy chain (HCh) is required for the maximal affinity of fVIII for vWf. alpha-hexachlorocyclohexane 132-135 coagulation factor VIII Homo sapiens 177-182 10480230-6 1999 The finding that Kd of LCh binding to vWf (3.8 nM) is 9.5 times higher than that of fVIII (0.4 nM), indicates that the heavy chain (HCh) is required for the maximal affinity of fVIII for vWf. alpha-hexachlorocyclohexane 132-135 von Willebrand factor Homo sapiens 187-190