PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33629301-6	2021	CONCLUSIONS: Our results demonstrated that kaempferol suppressed GBC progression through activation of the CDK4/CDK6/cyclin D1 signaling pathway, suggesting that it might be a potential anti-tumor agent for clinical treatment of GBC.	Kaempferols	43-53	cyclin dependent kinase 4	Homo sapiens	107-111
33629301-0	2021	Kaempferol suppresses proliferation and induces apoptosis and DNA damage in human gallbladder cancer cells through the CDK4/CDK6/cyclin D1 pathway.	Kaempferols	0-10	cyclin dependent kinase 4	Homo sapiens	119-123
33629301-6	2021	CONCLUSIONS: Our results demonstrated that kaempferol suppressed GBC progression through activation of the CDK4/CDK6/cyclin D1 signaling pathway, suggesting that it might be a potential anti-tumor agent for clinical treatment of GBC.	Kaempferols	43-53	cyclin dependent kinase 6	Homo sapiens	112-116
33629301-0	2021	Kaempferol suppresses proliferation and induces apoptosis and DNA damage in human gallbladder cancer cells through the CDK4/CDK6/cyclin D1 pathway.	Kaempferols	0-10	cyclin dependent kinase 6	Homo sapiens	124-128
33629301-6	2021	CONCLUSIONS: Our results demonstrated that kaempferol suppressed GBC progression through activation of the CDK4/CDK6/cyclin D1 signaling pathway, suggesting that it might be a potential anti-tumor agent for clinical treatment of GBC.	Kaempferols	43-53	cyclin D1	Homo sapiens	117-126
33629301-0	2021	Kaempferol suppresses proliferation and induces apoptosis and DNA damage in human gallbladder cancer cells through the CDK4/CDK6/cyclin D1 pathway.	Kaempferols	0-10	cyclin D1	Homo sapiens	129-138
31662136-6	2020	The mRNA level of the apoptosis-related gene Caspase-3 was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genes COX2 and SOX2 was significantly increased in the KAE-treated group compared with that in the control group.	Kaempferols	111-114	caspase 3	Homo sapiens	45-54
33629301-3	2021	RESULTS: Kaempferol promoted the release of cytochrome C from the mitochondria to cytoplasm, the activation of c-caspase-3 and c-caspase-9 and increased the expression levels of pro-apoptotic factor Bax, meanwhile decreased the expression levels of anti-apoptotic factor Bcl-2.	Kaempferols	9-19	caspase 3	Homo sapiens	113-122
33629301-3	2021	RESULTS: Kaempferol promoted the release of cytochrome C from the mitochondria to cytoplasm, the activation of c-caspase-3 and c-caspase-9 and increased the expression levels of pro-apoptotic factor Bax, meanwhile decreased the expression levels of anti-apoptotic factor Bcl-2.	Kaempferols	9-19	BCL2 associated X, apoptosis regulator	Homo sapiens	199-202
33629301-3	2021	RESULTS: Kaempferol promoted the release of cytochrome C from the mitochondria to cytoplasm, the activation of c-caspase-3 and c-caspase-9 and increased the expression levels of pro-apoptotic factor Bax, meanwhile decreased the expression levels of anti-apoptotic factor Bcl-2.	Kaempferols	9-19	BCL2 apoptosis regulator	Homo sapiens	271-276
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin dependent kinase 4	Homo sapiens	38-42
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin dependent kinase 6	Homo sapiens	44-48
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin D1	Homo sapiens	53-62
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin dependent kinase 4	Homo sapiens	89-93
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin dependent kinase 6	Homo sapiens	94-98
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin D1	Homo sapiens	99-108
31578905-5	2020	Kaempferol could inhibit CYP2A6 with Kic value of 1.77 +- 0.47 microM while inhibit CYP2A13 with Kic value of 0.12 +- 0.01 microM.	Kaempferols	0-10	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	25-31
31578905-5	2020	Kaempferol could inhibit CYP2A6 with Kic value of 1.77 +- 0.47 microM while inhibit CYP2A13 with Kic value of 0.12 +- 0.01 microM.	Kaempferols	0-10	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	84-91
31662136-6	2020	The mRNA level of the apoptosis-related gene Caspase-3 was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genes COX2 and SOX2 was significantly increased in the KAE-treated group compared with that in the control group.	Kaempferols	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-225
31662136-6	2020	The mRNA level of the apoptosis-related gene Caspase-3 was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genes COX2 and SOX2 was significantly increased in the KAE-treated group compared with that in the control group.	Kaempferols	111-114	SRY-box transcription factor 2	Homo sapiens	230-234
31662136-6	2020	The mRNA level of the apoptosis-related gene Caspase-3 was significantly lower in the blastocysts derived from KAE-treated oocytes than in the control group and the mRNA expression of the embryo development-related genes COX2 and SOX2 was significantly increased in the KAE-treated group compared with that in the control group.	Kaempferols	270-273	caspase 3	Homo sapiens	45-54
31662136-8	2020	Mitochondrial membrane potential (DeltaPsim) was increased and the activity of Caspase-3 was significantly decreased in the KAE-treated group compared with that in the control group.	Kaempferols	124-127	caspase 3	Homo sapiens	79-88
31871879-7	2019	The downstream targets of androgen receptors, such as PSA, TMPRSS2, and TMEPA1, were found decreased in the presence of kaempferol in qPCR data.	Kaempferols	120-130	aminopeptidase puromycin sensitive	Homo sapiens	54-57
31871879-7	2019	The downstream targets of androgen receptors, such as PSA, TMPRSS2, and TMEPA1, were found decreased in the presence of kaempferol in qPCR data.	Kaempferols	120-130	transmembrane serine protease 2	Homo sapiens	59-66
31655554-5	2019	RESULTS: Here we provide evidence that the previously described tomato wound and pathogen-induced glycosyltransferase Twi1 displays in vitro activity toward the coumarins scopoletin, umbelliferone and esculetin, and the flavonoids quercetin and kaempferol, by uncovering a new role of this gene in plant glycosylation.	Kaempferols	245-255	scopoletin glucosyltransferase	Solanum lycopersicum	118-122
31678747-0	2019	Kaempferol stimulates WNT/beta-catenin signaling pathway to induce differentiation of osteoblasts.	Kaempferols	0-10	catenin beta 1	Homo sapiens	26-38
31678747-3	2019	In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase (ALP) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.	Kaempferols	36-46	alkaline phosphatase, placental	Homo sapiens	119-139
31678747-3	2019	In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase (ALP) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.	Kaempferols	36-46	alkaline phosphatase, placental	Homo sapiens	141-144
31678747-3	2019	In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase (ALP) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.	Kaempferols	36-46	RUNX family transcription factor 2	Homo sapiens	206-211
31678747-3	2019	In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase (ALP) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.	Kaempferols	36-46	Sp7 transcription factor	Homo sapiens	213-220
31678747-3	2019	In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase (ALP) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.	Kaempferols	36-46	secreted phosphoprotein 1	Homo sapiens	222-233
31678747-5	2019	The stimulation of SaOS-2 cells by kaempferol resulted in an increased activity of WNT signaling responsive reporter construct, Axin-2, and, subsequently, stabilization of WNT signaling mediated transcription factor beta-catenin, probably leading to the activation of WNT-targeted genes for osteogenesis.	Kaempferols	35-45	axin 2	Homo sapiens	128-134
31678747-5	2019	The stimulation of SaOS-2 cells by kaempferol resulted in an increased activity of WNT signaling responsive reporter construct, Axin-2, and, subsequently, stabilization of WNT signaling mediated transcription factor beta-catenin, probably leading to the activation of WNT-targeted genes for osteogenesis.	Kaempferols	35-45	catenin beta 1	Homo sapiens	216-228
31678747-6	2019	In corroboration, the kaempferol-induced ALP activity was fully abolished by FH 535, an inhibitor of WNT signaling pathway.	Kaempferols	22-32	alkaline phosphatase, placental	Homo sapiens	41-44
31678747-7	2019	Kaempferol mediated activation of WNT signaling pathway through estrogen signaling pathway, as the application of ICI 182,780 (an inhibitor for estrogen receptors) markedly inhibited kaempferol-induced WNT signaling activation and osteogenic marker like ALP activity in SaOS-2 cells.	Kaempferols	0-10	alkaline phosphatase, placental	Homo sapiens	254-257
31678747-7	2019	Kaempferol mediated activation of WNT signaling pathway through estrogen signaling pathway, as the application of ICI 182,780 (an inhibitor for estrogen receptors) markedly inhibited kaempferol-induced WNT signaling activation and osteogenic marker like ALP activity in SaOS-2 cells.	Kaempferols	183-193	alkaline phosphatase, placental	Homo sapiens	254-257
31678747-8	2019	Immunohistochemical studies in drill-hole defect model showed increased expression of Runx2 and beta-catenin staining after kaempferol treatment.	Kaempferols	124-134	runt-related transcription factor 2	Mandrillus leucophaeus	86-91
31678747-8	2019	Immunohistochemical studies in drill-hole defect model showed increased expression of Runx2 and beta-catenin staining after kaempferol treatment.	Kaempferols	124-134	catenin beta 1	Homo sapiens	96-108
31605603-0	2019	IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.	Kaempferols	66-76	IQ motif containing GTPase activating protein 3	Homo sapiens	0-47
31605603-0	2019	IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.	Kaempferols	66-76	IQ motif containing GTPase activating protein 3	Homo sapiens	49-55
31605603-0	2019	IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.	Kaempferols	66-76	mitogen-activated protein kinase 1	Homo sapiens	121-163
31605603-0	2019	IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.	Kaempferols	66-76	mitogen-activated protein kinase 3	Homo sapiens	165-171
31605603-2	2019	The interaction between Kaempferol and IQ motif containing GTPase-activating protein 3 (IQGAP3) in BC and its underlying mechanism are poorly defined.	Kaempferols	24-34	IQ motif containing GTPase activating protein 3	Homo sapiens	39-86
31605603-2	2019	The interaction between Kaempferol and IQ motif containing GTPase-activating protein 3 (IQGAP3) in BC and its underlying mechanism are poorly defined.	Kaempferols	24-34	IQ motif containing GTPase activating protein 3	Homo sapiens	88-94
31605603-6	2019	RESULTS We found that natural phytochemicals, especially Kaempferol, decreased IQGAP3 expression in BC cells.	Kaempferols	57-67	IQ motif containing GTPase activating protein 3	Homo sapiens	79-85
31605603-7	2019	Kaempferol significantly induced proliferation inhibition and apoptosis in BC cells, concurrent with decreased IQGAP3 expression.	Kaempferols	0-10	IQ motif containing GTPase activating protein 3	Homo sapiens	111-117
31605603-8	2019	Upregulation of IQGAP3 inhibited apoptosis in BC cells, along with increased expression of phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2) and B cell lymphoma 2 (Bcl2) and decreased Bcl-2-associated X protein (Bax) expression, which was counteracted by Kaempferol treatment.	Kaempferols	274-284	IQ motif containing GTPase activating protein 3	Homo sapiens	16-22
31605603-9	2019	EGF markedly inhibited Kaempferol-induced apoptosis in BC cells, and ERK1/2 inhibitor PD98059 had an effect similar to that of Kaempferol.	Kaempferols	23-33	epidermal growth factor	Homo sapiens	0-3
31605603-10	2019	CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation.	Kaempferols	54-64	IQ motif containing GTPase activating protein 3	Homo sapiens	12-18
31605603-10	2019	CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation.	Kaempferols	54-64	mitogen-activated protein kinase 3	Homo sapiens	169-175
31605603-10	2019	CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation.	Kaempferols	125-135	IQ motif containing GTPase activating protein 3	Homo sapiens	109-115
31605603-10	2019	CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation.	Kaempferols	125-135	mitogen-activated protein kinase 3	Homo sapiens	169-175
31655554-9	2019	Twi1 glycosyltransferase showed to regulate quercetin and kaempferol levels in tomato plants, affecting plant resistance to viral infection.	Kaempferols	58-68	scopoletin glucosyltransferase	Solanum lycopersicum	0-4
32002970-17	2018	CONCLUSION: Kaempferol relaxes rat pulmonary artery in endothelium-independent manner through involvement of BKCa channel, sGC, PKA pathways and inhibition of Ca2+-influx through L-type calcium channels.	Kaempferols	12-22	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	109-113
31549524-0	2019	Kaempferol alleviates LPS-ATP mediated inflammatory injury in splenic lymphocytes via regulation of the pyroptosis pathway in mice.	Kaempferols	0-10	toll-like receptor 4	Mus musculus	22-25
31549524-6	2019	Results: The results show that kaempferol alleviates LPS-ATP mediated damage by increasing cell viability, improving membrane integrity, and decreasing the release of IL1b and IL-18.	Kaempferols	31-41	toll-like receptor 4	Mus musculus	53-56
31549524-6	2019	Results: The results show that kaempferol alleviates LPS-ATP mediated damage by increasing cell viability, improving membrane integrity, and decreasing the release of IL1b and IL-18.	Kaempferols	31-41	interleukin 1 beta	Mus musculus	167-171
31549524-6	2019	Results: The results show that kaempferol alleviates LPS-ATP mediated damage by increasing cell viability, improving membrane integrity, and decreasing the release of IL1b and IL-18.	Kaempferols	31-41	interleukin 18	Mus musculus	176-181
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	caspase 1	Mus musculus	76-85
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	toll-like receptor 4	Mus musculus	124-144
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	toll-like receptor 4	Mus musculus	146-150
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	NLR family, pyrin domain containing 3	Mus musculus	156-175
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	NLR family, pyrin domain containing 3	Mus musculus	177-182
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	gasdermin D	Mus musculus	224-235
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	gasdermin D	Mus musculus	237-242
32002970-17	2018	CONCLUSION: Kaempferol relaxes rat pulmonary artery in endothelium-independent manner through involvement of BKCa channel, sGC, PKA pathways and inhibition of Ca2+-influx through L-type calcium channels.	Kaempferols	12-22	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	123-126