PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30131878-1	2018	Docosahexaenoic acid (DHA) and their CYP-derived metabolites, epoxydocosapentaenoic acids (EDPs), are important fatty acids obtained from dietary sources.	edps	91-95	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	37-40
9872597-7	1998	A reverse zymography analysis revealed that EDPs also stimulated TIMP-2 (but not TIMP-1) production by HT-1080 cells.	edps	44-48	TIMP metallopeptidase inhibitor 2	Homo sapiens	65-71
29802129-6	2018	The accumulation of EDPs induces hepatic lipogenesis (i.e., SREBP1c and ACC), inflammation (i.e., Kupffer cells, IL-1beta, and TGF-beta), and fibrosis (collagen and elastin expression).	edps	20-24	sterol regulatory element binding transcription factor 1	Mus musculus	60-67
29802129-6	2018	The accumulation of EDPs induces hepatic lipogenesis (i.e., SREBP1c and ACC), inflammation (i.e., Kupffer cells, IL-1beta, and TGF-beta), and fibrosis (collagen and elastin expression).	edps	20-24	interleukin 1 beta	Mus musculus	113-121
29802129-6	2018	The accumulation of EDPs induces hepatic lipogenesis (i.e., SREBP1c and ACC), inflammation (i.e., Kupffer cells, IL-1beta, and TGF-beta), and fibrosis (collagen and elastin expression).	edps	20-24	transforming growth factor, beta 1	Mus musculus	127-135
29802129-6	2018	The accumulation of EDPs induces hepatic lipogenesis (i.e., SREBP1c and ACC), inflammation (i.e., Kupffer cells, IL-1beta, and TGF-beta), and fibrosis (collagen and elastin expression).	edps	20-24	elastin	Mus musculus	165-172
28827330-6	2017	We discovered that the CYP-derived lipid metabolites epoxydocosapentaenoic acids (EDPs) and epoxyeicosatetraenoic acids (EEQs) are vital in dampening CNV severity.	edps	82-86	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	23-26
27634339-3	2017	DHA is metabolized into epoxydocosapentanoic acids (EDPs) via cytochrome P450 (CYP450) enzymes which are substrates for the soluble epoxide hydrolase (sEH) enzyme.	edps	52-56	epoxide hydrolase 2, cytoplasmic	Mus musculus	124-149
27634339-3	2017	DHA is metabolized into epoxydocosapentanoic acids (EDPs) via cytochrome P450 (CYP450) enzymes which are substrates for the soluble epoxide hydrolase (sEH) enzyme.	edps	52-56	epoxide hydrolase 2, cytoplasmic	Mus musculus	151-154
27182450-5	2015	Emerging evidence indicates that cytochrome P450 (CYP) epoxygenase metabolites of DHA, epoxydocosapentaenoic acids (EDPs), produce more potent biological activity compared to its precursor DHA.	edps	116-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-48
27182450-5	2015	Emerging evidence indicates that cytochrome P450 (CYP) epoxygenase metabolites of DHA, epoxydocosapentaenoic acids (EDPs), produce more potent biological activity compared to its precursor DHA.	edps	116-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-53
28672272-5	2017	We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues.	edps	49-53	axin 2	Mus musculus	180-185
28672272-5	2017	We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues.	edps	49-53	jun proto-oncogene	Mus musculus	191-196
24904926-8	2014	HRPE cells treated with glucose or EDPs with the addition of atorvastatin had a statistically significant decrease of TIMP-2 expression; glucose alone decreased MMP-1 expression.	edps	35-39	TIMP metallopeptidase inhibitor 2	Homo sapiens	118-124
24904926-8	2014	HRPE cells treated with glucose or EDPs with the addition of atorvastatin had a statistically significant decrease of TIMP-2 expression; glucose alone decreased MMP-1 expression.	edps	35-39	matrix metallopeptidase 1	Homo sapiens	161-166