PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8224190-1	1993	The ability of the Escherichia coli single-stranded DNA-binding protein (SSB) to recognize structural features associated with intramolecular triplex formation in oligopurine.oligopyrimidine (pur.pyr) inserts in recombinant plasmids was evaluated.	oligopyrimidine	175-190	single-stranded DNA-binding protein	Escherichia coli	36-71
8774898-1	1996	Exon 5 of the human aprt gene contains an oligo-purine-oligopyrimidine stretch of 17 bp (5"-CCCTCTTCTCTCTCCT-3") within the coding region.	oligopyrimidine	55-70	adenine phosphoribosyltransferase	Homo sapiens	20-24
7601137-6	1995	The activity of the rpL30 promoter was significantly diminished when three pyrimidine residues spanning the start site were converted to purines, indicating that the integrity of the oligopyrimidine tract is also a determinant of the transcriptional efficiency.	oligopyrimidine	183-198	ribosomal protein L30	Mus musculus	20-25
8224190-1	1993	The ability of the Escherichia coli single-stranded DNA-binding protein (SSB) to recognize structural features associated with intramolecular triplex formation in oligopurine.oligopyrimidine (pur.pyr) inserts in recombinant plasmids was evaluated.	oligopyrimidine	175-190	single-stranded DNA-binding protein	Escherichia coli	73-76
1309767-4	1992	Similarly, other oligopurine.oligopyrimidine mirror repeat sequences (i.e. (GAA)8 or (GGA)8) formed only the H-y3 under all experimental conditions.	oligopyrimidine	29-44	alpha glucosidase	Homo sapiens	76-79
34255842-3	2021	First, we use capCLIP to identify the eIF4E cap-omes in human cells with/without the mTORC1 (mechanistic target of rapamycin, complex 1) inhibitor rapamycin, there being an emerging consensus that rapamycin inhibits translation of TOP (terminal oligopyrimidine) mRNAs by displacing eIF4E from their caps.	oligopyrimidine	245-260	eukaryotic translation initiation factor 4E	Homo sapiens	38-43
34449924-8	2022	We found the most striking change was hyperphosphorylation and increased content of La-Related Protein 1 (LARP1), which in the unphosphorylated form negatively regulates translation of 5"-terminal oligopyrimidine (TOP)-containing mRNAs.	oligopyrimidine	197-212	La ribonucleoprotein domain family, member 1	Mus musculus	84-104
34449924-8	2022	We found the most striking change was hyperphosphorylation and increased content of La-Related Protein 1 (LARP1), which in the unphosphorylated form negatively regulates translation of 5"-terminal oligopyrimidine (TOP)-containing mRNAs.	oligopyrimidine	197-212	La ribonucleoprotein 1, translational regulator	Homo sapiens	106-111
34255842-3	2021	First, we use capCLIP to identify the eIF4E cap-omes in human cells with/without the mTORC1 (mechanistic target of rapamycin, complex 1) inhibitor rapamycin, there being an emerging consensus that rapamycin inhibits translation of TOP (terminal oligopyrimidine) mRNAs by displacing eIF4E from their caps.	oligopyrimidine	245-260	eukaryotic translation initiation factor 4E	Homo sapiens	282-287
32233986-1	2021	The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation.	oligopyrimidine	144-159	La ribonucleoprotein 1, translational regulator	Homo sapiens	24-29
34127534-0	2021	Genes with 5" terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 NSP1 protein.	oligopyrimidine	23-38	SH2 domain containing 3A	Homo sapiens	120-124
33284085-11	2021	Purine substitutions to disrupt a terminal oligopyrimidine (TOP)-like sequence in the Rbp4 5"-UTRprevented the suppressive effect of rapamycin on reporter activity.	oligopyrimidine	43-58	retinol binding protein 4	Rattus norvegicus	86-90
27877176-5	2016	We have identified in the 5" untranslated regions (UTRs) of this set of genes a conserved sequence related to the 5" terminal oligopyrimidine motif, which is known to confer translational regulation by the TOR kinase in other eukaryotes.	oligopyrimidine	126-141	target of rapamycin	Arabidopsis thaliana	206-209
32803350-5	2020	TDP-43 binds to and transports the RP mRNAs through their 5" untranslated region, which contains a common 5" terminal oligopyrimidine tract motif and a downstream GC-rich region.	oligopyrimidine	118-133	TAR DNA binding protein	Homo sapiens	0-6
32576685-6	2020	At the translational level, we uncovered sustained down-regulation of a set of 5"-terminal oligopyrimidine (5"-TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway.	oligopyrimidine	91-106	mechanistic target of rapamycin kinase	Mus musculus	210-214
32094190-1	2020	Terminal oligopyrimidine (TOP) motifs are sequences at the 5" ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway.	oligopyrimidine	9-24	CREB regulated transcription coactivator 1	Mus musculus	127-133
31483294-5	2019	These mTOR targets were found to be regulated by novel mTOR-responsive 5"-UTR motifs, distinct from known mTOR inhibition-sensitive targets regulated by 5" terminal oligopyrimidine motifs.	oligopyrimidine	165-180	mechanistic target of rapamycin kinase	Homo sapiens	6-10
31483294-5	2019	These mTOR targets were found to be regulated by novel mTOR-responsive 5"-UTR motifs, distinct from known mTOR inhibition-sensitive targets regulated by 5" terminal oligopyrimidine motifs.	oligopyrimidine	165-180	mechanistic target of rapamycin kinase	Homo sapiens	55-59
31551760-5	2019	At the molecular level, biochemical assays on the hippocampus showed dysregulation of signaling pathways controlling protein synthesis capacity including: up-regulation of AKT-mTORC1-p70S6K signaling, which is associated with translation of terminal oligopyrimidine (TOP) class of mRNAs that encode translational machinery; hyper-phosphorylation of mRNA translational elongation factor 2 (eEF2) and its upstream regulator AMP-activated protein kinase (AMPK), indicating repression of general protein synthesis.	oligopyrimidine	250-265	thymoma viral proto-oncogene 1	Mus musculus	172-175
31551760-5	2019	At the molecular level, biochemical assays on the hippocampus showed dysregulation of signaling pathways controlling protein synthesis capacity including: up-regulation of AKT-mTORC1-p70S6K signaling, which is associated with translation of terminal oligopyrimidine (TOP) class of mRNAs that encode translational machinery; hyper-phosphorylation of mRNA translational elongation factor 2 (eEF2) and its upstream regulator AMP-activated protein kinase (AMPK), indicating repression of general protein synthesis.	oligopyrimidine	250-265	CREB regulated transcription coactivator 1	Mus musculus	176-182
31551760-5	2019	At the molecular level, biochemical assays on the hippocampus showed dysregulation of signaling pathways controlling protein synthesis capacity including: up-regulation of AKT-mTORC1-p70S6K signaling, which is associated with translation of terminal oligopyrimidine (TOP) class of mRNAs that encode translational machinery; hyper-phosphorylation of mRNA translational elongation factor 2 (eEF2) and its upstream regulator AMP-activated protein kinase (AMPK), indicating repression of general protein synthesis.	oligopyrimidine	250-265	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	183-189
31399545-4	2019	KRAS was identified to promote eIF4A-dependent ARF6 mRNA translation, which contains a quadruplex structure at its 5"-untranslated region, by inducing TEAD3 and ETV4 to suppress PDCD4; and also eIF4E-dependent AMAP1 mRNA translation, which contains a 5"-terminal oligopyrimidine-like sequence, via up-regulating mTORC1.	oligopyrimidine	263-278	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
31399545-4	2019	KRAS was identified to promote eIF4A-dependent ARF6 mRNA translation, which contains a quadruplex structure at its 5"-untranslated region, by inducing TEAD3 and ETV4 to suppress PDCD4; and also eIF4E-dependent AMAP1 mRNA translation, which contains a 5"-terminal oligopyrimidine-like sequence, via up-regulating mTORC1.	oligopyrimidine	263-278	eukaryotic translation initiation factor 4A2	Homo sapiens	31-36
31399545-4	2019	KRAS was identified to promote eIF4A-dependent ARF6 mRNA translation, which contains a quadruplex structure at its 5"-untranslated region, by inducing TEAD3 and ETV4 to suppress PDCD4; and also eIF4E-dependent AMAP1 mRNA translation, which contains a 5"-terminal oligopyrimidine-like sequence, via up-regulating mTORC1.	oligopyrimidine	263-278	ADP ribosylation factor 6	Homo sapiens	47-51
29039571-1	2017	La-related protein 1 (LARP1) is a conserved RNA-binding protein and is known to regulate 5"-terminal oligopyrimidine tract (TOP) mRNA translation.	oligopyrimidine	101-116	La ribonucleoprotein 1, translational regulator	Homo sapiens	0-20
29039571-1	2017	La-related protein 1 (LARP1) is a conserved RNA-binding protein and is known to regulate 5"-terminal oligopyrimidine tract (TOP) mRNA translation.	oligopyrimidine	101-116	La ribonucleoprotein 1, translational regulator	Homo sapiens	22-27
33054857-5	2020	RESULTS: Ribosome profiling reveals that in Tsc2+/- mouse hippocampal slices, the expression of several mRNAs was dysregulated: terminal oligopyrimidine (TOP)-containing mRNAs decreased, while FMRP-binding targets increased.	oligopyrimidine	137-152	TSC complex subunit 2	Mus musculus	44-48
32995776-0	2021	Genes with 5" terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 NSP1 protein.	oligopyrimidine	23-38	SH2 domain containing 3A	Homo sapiens	120-124
31723047-6	2019	One motif occurs at ETS family transcription factor binding sites, known to be UV targets and now shown to be among the most sensitive in the genome, and at sites of mTOR/5" terminal oligopyrimidine-tract translation regulation.	oligopyrimidine	183-198	mechanistic target of rapamycin kinase	Homo sapiens	166-170
31483294-5	2019	These mTOR targets were found to be regulated by novel mTOR-responsive 5"-UTR motifs, distinct from known mTOR inhibition-sensitive targets regulated by 5" terminal oligopyrimidine motifs.	oligopyrimidine	165-180	mechanistic target of rapamycin kinase	Homo sapiens	55-59
30008325-4	2018	Mechanistically, we demonstrated that mTORC1 selectively controls the RNA translation of Sox9, which harbors a 5" terminal oligopyrimidine tract motif, via inhibition of the 4E-BPs.	oligopyrimidine	123-138	CREB regulated transcription coactivator 1	Mus musculus	38-44
30008325-4	2018	Mechanistically, we demonstrated that mTORC1 selectively controls the RNA translation of Sox9, which harbors a 5" terminal oligopyrimidine tract motif, via inhibition of the 4E-BPs.	oligopyrimidine	123-138	SRY-box transcription factor 9	Homo sapiens	89-93
26207988-2	2015	However, mTOR-sensitive translatomes commonly include mRNAs with a 5" terminal oligopyrimidine tract (TOP), such as those encoding ribosomal proteins, but not ISGs.	oligopyrimidine	79-94	mechanistic target of rapamycin kinase	Homo sapiens	9-13
26984228-2	2016	Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation of the TOP (terminal oligopyrimidine motif) and TOP-like mRNAs, polysome-profiling indicated that MTOR also modulates translation of mRNAs without the 5" TOP motif (non-TOP mRNAs).	oligopyrimidine	110-125	mechanistic target of rapamycin kinase	Homo sapiens	42-46
26763232-7	2016	In addition, DHA-dependent activation of the Akt-mTOR-S6K pathway enhanced 5"-terminal oligopyrimidine tract-dependent translation of Tau and CRMP2.	oligopyrimidine	87-102	AKT serine/threonine kinase 1	Homo sapiens	45-48
26763232-7	2016	In addition, DHA-dependent activation of the Akt-mTOR-S6K pathway enhanced 5"-terminal oligopyrimidine tract-dependent translation of Tau and CRMP2.	oligopyrimidine	87-102	mechanistic target of rapamycin kinase	Homo sapiens	49-53
26763232-7	2016	In addition, DHA-dependent activation of the Akt-mTOR-S6K pathway enhanced 5"-terminal oligopyrimidine tract-dependent translation of Tau and CRMP2.	oligopyrimidine	87-102	dihydropyrimidinase like 2	Homo sapiens	142-147
25531318-2	2015	La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5"-terminal oligopyrimidine tract (TOP) mRNA translation.	oligopyrimidine	128-143	La ribonucleoprotein 1, translational regulator	Homo sapiens	0-20
25531318-2	2015	La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5"-terminal oligopyrimidine tract (TOP) mRNA translation.	oligopyrimidine	128-143	La ribonucleoprotein 1, translational regulator	Homo sapiens	22-27
25531318-2	2015	La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5"-terminal oligopyrimidine tract (TOP) mRNA translation.	oligopyrimidine	128-143	retinol binding protein 4	Homo sapiens	44-47
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	ribosomal protein L22	Homo sapiens	346-367
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	ribosomal protein L37	Homo sapiens	372-375
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	cyclin D1	Homo sapiens	423-432
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	cyclin D1	Homo sapiens	434-439
25936523-2	2015	To understand the mechanisms underlying the accumulation of high TCTP levels in cancer cells, we studied the signalling pathways that control translation of TCTP mRNA, which contains a 5"-terminal oligopyrimidine tract (5"-TOP).	oligopyrimidine	197-212	tumor protein, translationally-controlled 1	Homo sapiens	157-161
25940091-0	2015	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	oligopyrimidine	48-63	La ribonucleoprotein 1, translational regulator	Homo sapiens	0-20
25940091-0	2015	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	oligopyrimidine	48-63	La ribonucleoprotein 1, translational regulator	Homo sapiens	22-27
25940091-0	2015	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	oligopyrimidine	48-63	CREB regulated transcription coactivator 1	Mus musculus	117-123
25940091-3	2015	In this study, we identify the La-related protein 1 (LARP1) as a key novel target of mTORC1 with a fundamental role in terminal oligopyrimidine (TOP) mRNA translation.	oligopyrimidine	128-143	La ribonucleoprotein 1, translational regulator	Homo sapiens	31-51
25940091-3	2015	In this study, we identify the La-related protein 1 (LARP1) as a key novel target of mTORC1 with a fundamental role in terminal oligopyrimidine (TOP) mRNA translation.	oligopyrimidine	128-143	La ribonucleoprotein 1, translational regulator	Homo sapiens	53-58
25940091-3	2015	In this study, we identify the La-related protein 1 (LARP1) as a key novel target of mTORC1 with a fundamental role in terminal oligopyrimidine (TOP) mRNA translation.	oligopyrimidine	128-143	CREB regulated transcription coactivator 1	Mus musculus	85-91
24648524-8	2014	This eIF2alpha-P-independent network includes (i) inhibition of mammalian target of rapamycin kinase protein complex 1 (mTORC1)-targeted protein phosphorylation, (ii) inhibited translation of a selective group of 5"-terminal oligopyrimidine mRNAs (encoding proteins involved in the translation machinery and translationally controlled by mTORC1 signaling), and (iii) inhibited translation of non-5"-terminal oligopyrimidine ribosomal protein mRNAs and ribosomal RNA biogenesis.	oligopyrimidine	225-240	CREB regulated transcription coactivator 1	Mus musculus	338-344
25762659-5	2015	By developing a novel assay to label nascent peptidic chains, we show that the rpS6 phosphorylation induced in striatonigral MSNs by d-amph, as well as in striatopallidal MSNs by the antipsychotic haloperidol or in both subtypes by papaverine, is not correlated with the translation of global or 5" terminal oligopyrimidine tract mRNAs.	oligopyrimidine	308-323	ribosomal protein S6	Mus musculus	79-83
24648524-8	2014	This eIF2alpha-P-independent network includes (i) inhibition of mammalian target of rapamycin kinase protein complex 1 (mTORC1)-targeted protein phosphorylation, (ii) inhibited translation of a selective group of 5"-terminal oligopyrimidine mRNAs (encoding proteins involved in the translation machinery and translationally controlled by mTORC1 signaling), and (iii) inhibited translation of non-5"-terminal oligopyrimidine ribosomal protein mRNAs and ribosomal RNA biogenesis.	oligopyrimidine	225-240	eukaryotic translation initiation factor 2A	Homo sapiens	5-14
23129244-4	2012	In addition, Gcn2 modulates translation of novel mRNAs such as those of an unknown regulator of leucine transport and of sulfiredoxin SRX1 in yeast (activation of translation) and of inducible nitric oxide synthase, ErBb2, HIF1a, and 5"-terminal oligopyrimidine tract mRNAs in mammals (inhibition of translation).	oligopyrimidine	246-261	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	13-17
24648524-8	2014	This eIF2alpha-P-independent network includes (i) inhibition of mammalian target of rapamycin kinase protein complex 1 (mTORC1)-targeted protein phosphorylation, (ii) inhibited translation of a selective group of 5"-terminal oligopyrimidine mRNAs (encoding proteins involved in the translation machinery and translationally controlled by mTORC1 signaling), and (iii) inhibited translation of non-5"-terminal oligopyrimidine ribosomal protein mRNAs and ribosomal RNA biogenesis.	oligopyrimidine	225-240	CREB regulated transcription coactivator 1	Mus musculus	120-126
24532714-5	2014	Our results indicate that LARP1 associates with actively translating ribosomes via PABP and that LARP1 stimulates the translation of mRNAs containing a 5" terminal oligopyrimidine (TOP) motif, encoding for components of the translational machinery.	oligopyrimidine	164-179	poly(A) binding protein cytoplasmic 1	Homo sapiens	83-87
24532714-5	2014	Our results indicate that LARP1 associates with actively translating ribosomes via PABP and that LARP1 stimulates the translation of mRNAs containing a 5" terminal oligopyrimidine (TOP) motif, encoding for components of the translational machinery.	oligopyrimidine	164-179	La ribonucleoprotein 1, translational regulator	Homo sapiens	97-102
24824036-7	2014	Our findings provide new insight into the role of RRM3 in regulating TIA-1 binding to C-rich stretches, that are abundant at the 5" TOPs (5" terminal oligopyrimidine tracts) of mRNAs whose translation is repressed under stress situations.	oligopyrimidine	150-165	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	69-74
22552098-6	2012	The subset of mRNAs that are specifically regulated by mTORC1 consists almost entirely of transcripts with established 5" terminal oligopyrimidine (TOP) motifs, or, like Hsp90ab1 and Ybx1, with previously unrecognized TOP or related TOP-like motifs that we identified.	oligopyrimidine	131-146	CREB regulated transcription coactivator 1	Mus musculus	55-61
22431630-5	2012	The 5" UTR within the mRNA encoding PABP contains a terminal oligopyrimidine (TOP) element found in mRNAs, the translation of which is stimulated in response to mitogenic, growth, and nutritional stimuli, and proteins encoded by TOP-containing mRNAs accumulated in HCMV-infected cells.	oligopyrimidine	61-76	poly(A) binding protein cytoplasmic 1	Homo sapiens	36-40
21955058-5	2011	Without any external perturbation, in oligopyrimidine SAMs one encounters an energy gradient that is generated by the dipole moments of the pyrimidine repeat units.	oligopyrimidine	38-53	methionine adenosyltransferase 1A	Homo sapiens	54-58
22428559-2	2012	mTORC1 controls the phosphorylation of several proteins involved in mRNA translation and the translation of specific mRNAs, including those containing a 5"-TOP (5"-terminal oligopyrimidine).	oligopyrimidine	173-188	CREB regulated transcription coactivator 1	Mus musculus	0-6
21102526-0	2011	Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5" terminal oligopyrimidine tract.	oligopyrimidine	115-130	ribosomal protein S6	Homo sapiens	0-20
21428917-8	2011	As expected, synthesis of proteins encoded by mRNAs that contain a 5"-TOP (5"-terminal oligopyrimidine tract) was impaired by rapamycin, but more strongly by mTOR kinase inhibition.	oligopyrimidine	87-102	mechanistic target of rapamycin kinase	Homo sapiens	158-162
21428924-1	2011	Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5"-TOP (5"-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway.	oligopyrimidine	83-98	growth arrest specific 5	Homo sapiens	15-19
21428924-1	2011	Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5"-TOP (5"-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway.	oligopyrimidine	83-98	growth arrest specific 5	Homo sapiens	21-56
21428924-1	2011	Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5"-TOP (5"-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway.	oligopyrimidine	83-98	mechanistic target of rapamycin kinase	Homo sapiens	184-188
21428924-1	2011	Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5"-TOP (5"-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway.	oligopyrimidine	83-98	mechanistic target of rapamycin kinase	Homo sapiens	190-219
21102526-8	2011	Low-dose rapamycin treatments have been shown to affect the translation of 5" terminal oligopyrimidine (5" TOP) tract mRNA, which encodes the translational machinery, implicating RPS6 in 5" TOP translation.	oligopyrimidine	87-102	ribosomal protein S6	Homo sapiens	179-183
20421347-6	2010	The GAS5 transcript is a member of the 5" terminal oligopyrimidine class of RNAs, which is specifically controlled at the level of translation by the mTOR pathway, and the effects of GAS5 on the cell cycle provide a novel and important link to the control of proliferation.	oligopyrimidine	51-66	growth arrest specific 5	Homo sapiens	4-8
20421347-6	2010	The GAS5 transcript is a member of the 5" terminal oligopyrimidine class of RNAs, which is specifically controlled at the level of translation by the mTOR pathway, and the effects of GAS5 on the cell cycle provide a novel and important link to the control of proliferation.	oligopyrimidine	51-66	mechanistic target of rapamycin kinase	Homo sapiens	150-154
20421347-6	2010	The GAS5 transcript is a member of the 5" terminal oligopyrimidine class of RNAs, which is specifically controlled at the level of translation by the mTOR pathway, and the effects of GAS5 on the cell cycle provide a novel and important link to the control of proliferation.	oligopyrimidine	51-66	growth arrest specific 5	Homo sapiens	183-187
20509958-0	2010	Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5" terminal oligopyrimidine tract (TOP) mRNAs by insulin.	oligopyrimidine	130-145	endothelin 1	Rattus norvegicus	64-88
20445056-8	2010	Our results also reveal that light-induced mTOR activation leads to the translation of mRNAs with a 5"-terminal oligopyrimidine tract such as eukaryotic elongation factor 1A and the immediate early gene JunB.	oligopyrimidine	112-127	mechanistic target of rapamycin kinase	Homo sapiens	43-47
20445056-8	2010	Our results also reveal that light-induced mTOR activation leads to the translation of mRNAs with a 5"-terminal oligopyrimidine tract such as eukaryotic elongation factor 1A and the immediate early gene JunB.	oligopyrimidine	112-127	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-207
19651701-5	2009	Green fluorescent protein (GFP), fused to oligopyrimidine tract sequences that were identified in the 5"-untranslated region (UTR) of AP3, PI and SUP, was translationally regulated in human cells in response to mitogen stimulation and inhibition by the macrolide antibiotic rapamycin.	oligopyrimidine	42-57	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	134-137
19648118-8	2009	In the 5"-untranslated region of Tau and CRMP2 mRNAs, we identified a 5"-terminal oligopyrimidine tract, which mediates mTOR-governed protein synthesis.	oligopyrimidine	82-97	dihydropyrimidinase like 2	Homo sapiens	41-46
19648118-8	2009	In the 5"-untranslated region of Tau and CRMP2 mRNAs, we identified a 5"-terminal oligopyrimidine tract, which mediates mTOR-governed protein synthesis.	oligopyrimidine	82-97	mechanistic target of rapamycin kinase	Homo sapiens	120-124
19648118-9	2009	The 5"-terminal oligopyrimidine tract sequences of CRMP2 and Tau mRNAs strongly contribute to the up-regulation of their translation in the axon in response to the axonal activation of the mTOR-p70S6K pathway.	oligopyrimidine	16-31	dihydropyrimidinase like 2	Homo sapiens	51-56
19648118-9	2009	The 5"-terminal oligopyrimidine tract sequences of CRMP2 and Tau mRNAs strongly contribute to the up-regulation of their translation in the axon in response to the axonal activation of the mTOR-p70S6K pathway.	oligopyrimidine	16-31	mechanistic target of rapamycin kinase	Homo sapiens	189-193
19648118-9	2009	The 5"-terminal oligopyrimidine tract sequences of CRMP2 and Tau mRNAs strongly contribute to the up-regulation of their translation in the axon in response to the axonal activation of the mTOR-p70S6K pathway.	oligopyrimidine	16-31	ribosomal protein S6 kinase B1	Homo sapiens	194-200
19605641-6	2009	We found that ZNF9 interacts with the 5" UTRs of terminal oligopyrimidine (TOP) tract mRNAs encoding human ribosomal protein, RPS17, poly(A)-binding protein 1 (PABP1), and the elongation factors, eEF1A and eEF2.	oligopyrimidine	58-73	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	14-18
19087191-10	2009	In addition, we provide evidence that the terminal oligopyrimidine cis-element of PABP1 mRNA is responsible for the preferential increase of PABP1 mRNA translation in cells undergoing recovery from heat shock.	oligopyrimidine	51-66	poly(A) binding protein cytoplasmic 1 pseudogene 1	Homo sapiens	82-87
19087191-10	2009	In addition, we provide evidence that the terminal oligopyrimidine cis-element of PABP1 mRNA is responsible for the preferential increase of PABP1 mRNA translation in cells undergoing recovery from heat shock.	oligopyrimidine	51-66	poly(A) binding protein cytoplasmic 1 pseudogene 1	Homo sapiens	141-146
17603996-0	2007	Identification of AUF1 as a rapamycin-responsive binding protein to the 5"-terminal oligopyrimidine element of mRNAs.	oligopyrimidine	84-99	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	18-22
18809972-5	2008	Remarkably, we found that inhibition of MNKs strongly reduced the polysomal recruitment of terminal oligopyrimidine messenger RNAs (TOP mRNAs), which are known targets of mTOR-dependent translational control.	oligopyrimidine	100-115	mechanistic target of rapamycin kinase	Homo sapiens	171-175
18638456-4	2008	In the present study, signaling through mTORC1 and translation of specific mRNAs such as those bearing a 5"-terminal oligopyrimidine (TOP) tract and were examined in rat liver following activation of AMPK after treadmill running.	oligopyrimidine	117-132	CREB regulated transcription coactivator 1	Mus musculus	40-46
18716165-1	2008	In intestinal cells, arginine (Arg) is 1 of the 2 most potent amino acid activators of p70(s6k), a key regulator of 5"- terminal oligopyrimidine mRNA translation, a necessary condition for increased cell migration.	oligopyrimidine	129-144	ribosomal protein S6 kinase B1	Rattus norvegicus	87-94
18466337-2	2008	mTOR regulates protein synthesis via phosphorylation of 4E-binding proteins (4E-BPs) and S6K, and via selective up-regulation of 5" terminal oligopyrimidine (5" TOP) mRNAs that encode components of the translational machinery.	oligopyrimidine	141-156	mechanistic target of rapamycin kinase	Homo sapiens	0-4
18653778-8	2008	It appears, therefore, that mTORC1 controls translation of leptin mRNA via a novel mechanism that does not require the presence of either the 5"-terminal oligopyrimidine tract or the 5"-UTR.	oligopyrimidine	154-169	leptin	Homo sapiens	59-65
17497933-3	2007	PTB RNA binding domains (RBDs) 3 and 4 and their complexes with oligopyrimidine RNAs were simulated using the GROMOS simulation software using the GROMOS 45A4 force field.	oligopyrimidine	64-79	polypyrimidine tract binding protein 1	Homo sapiens	0-3
17606477-7	2007	Our results indicate that IL-8 signaling (a) regulates cyclin D1 expression at the level of translation, (b) regulates the activation of proteins associated with the translation of capped and 5"-oligopyrimidine tract transcripts, and (c) activates signal transduction pathways underpinning AIPC cell proliferation.	oligopyrimidine	195-210	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
16356660-4	2006	Promoter study revealed that transcription of the mouse rpS3 gene started at two C residues embedded in the 5"-terminal oligopyrimidine tract (5"-TOP); this was then compared with the human counterpart.	oligopyrimidine	120-135	ribosomal protein S3	Mus musculus	56-60
16679021-4	2006	In addition to its role in glucose homeostasis in the whole mouse, phosphorylation of rpS6 is essential for regulating the size of at least some cell types, but is dispensable for translational control of mRNAs with a 5" terminal oligopyrimidine tract (TOP mRNAs) - its previously assigned targets.	oligopyrimidine	230-245	ribosomal protein S6	Mus musculus	86-90
15060135-0	2004	S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5"-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.	oligopyrimidine	89-104	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	0-4
16365054-9	2006	The functional importance of these observations was confirmed by polysome fractionation, which showed that translation initiation of 5" oligopyrimidine tract-containing mRNAs, which encode ribosomal proteins, was inhibited by rapamycin, whereas translation of signal transducer and activator of transcription 1 (STAT1), a cap-dependent mRNA, was unaffected.	oligopyrimidine	136-151	signal transducer and activator of transcription 1	Rattus norvegicus	312-317
16212959-5	2005	The results show that RACK1 mRNA has a 5" terminal oligopyrimidine sequence and that its translation is dependent on the availability of serum and amino acids in exactly the same way as any other vertebrate ribosomal protein mRNA.	oligopyrimidine	51-66	receptor for activated C kinase 1	Homo sapiens	22-27
15958750-3	2005	Here, we show in acute brain slices that the induction of protein synthesis-dependent hippocampal LTP increases the expression of elongation factor 1A (eEF1A), the mRNA of which contains a 5" terminal oligopyrimidine tract.	oligopyrimidine	201-216	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	152-157
15485924-0	2004	CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5"-terminal oligopyrimidine mRNA metabolism.	oligopyrimidine	105-120	ribosomal protein L37	Homo sapiens	87-92
15247270-5	2004	Identification of the transcription initiation site revealed that nm23-M2 mRNA starts with a terminal oligopyrimidine sequence, which is known to render mRNA translation dependent on mitogenic factors.	oligopyrimidine	102-117	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	66-70
15060135-0	2004	S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5"-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.	oligopyrimidine	89-104	ribosomal protein S6 kinase, polypeptide 2	Mus musculus	10-14
10749668-7	2000	Although both basal and IGF-I-stimulated rates of protein synthesis were modestly affected by glucocorticoids, the synthesis of EF1A, whose mRNA precursor is a prototype for the terminal oligopyrimidine ("TOP") transcript family and whose expression is controlled by the activity of p70(S6k), was markedly affected.	oligopyrimidine	187-202	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	128-132
12853148-1	2003	The human elongation factor 1A-1 (eEF1A-1) gene is a member of the 5" terminal oligopyrimidine tract (5" TOP) gene family, and the number of thymidines (Ts) at the 5" TOP of cDNAs corresponding to this gene is known to show variation.	oligopyrimidine	79-94	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	34-41
11019831-2	2000	The target sequence chosen for this study is a 16-base-long oligopurine-oligopyrimidine region present in the human neurotrophin 4/5 gene.	oligopyrimidine	72-87	neurotrophin 4	Homo sapiens	116-132
9880551-0	1999	The expression of poly(A)-binding protein gene is translationally regulated in a growth-dependent fashion through a 5"-terminal oligopyrimidine tract motif.	oligopyrimidine	128-143	poly(A) binding protein cytoplasmic 1	Homo sapiens	18-41
10338125-4	1999	The complexes formed by the RNA hairpin and either the 12-mer oligodeoxypyrimidine or the 20-mer oligopyrimidine are stable at a neutral pH and in the absence of Mg2+ but blocked neither the reverse transcription nor cell-free translation of a RNA template in which the gag-pol frameshifting hairpin was inserted at the 5" end of the luciferase open reading frame.	oligopyrimidine	97-112	Gag-Pol	Human immunodeficiency virus 1	270-277
9931479-2	1998	Both promoters, those of the CYC1 and DED1 genes, contain long oligopurine.oligopyrimidine (R.Y) tracts.	oligopyrimidine	75-90	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	29-33
9931479-2	1998	Both promoters, those of the CYC1 and DED1 genes, contain long oligopurine.oligopyrimidine (R.Y) tracts.	oligopyrimidine	75-90	DEAD-box ATP-dependent RNA helicase DED1	Saccharomyces cerevisiae S288C	38-42