PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18779369-7	2008	Our results reveal a developmental pathway that includes down-regulation of Notch, activation of the EcR, up-regulation of Ttk to execute the E/A switch, and, for the first time, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs and differentiation.	Ecdysone	221-229	Notch	Drosophila melanogaster	76-81
18779369-7	2008	Our results reveal a developmental pathway that includes down-regulation of Notch, activation of the EcR, up-regulation of Ttk to execute the E/A switch, and, for the first time, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs and differentiation.	Ecdysone	221-229	Ecdysone receptor	Drosophila melanogaster	101-104
18779369-7	2008	Our results reveal a developmental pathway that includes down-regulation of Notch, activation of the EcR, up-regulation of Ttk to execute the E/A switch, and, for the first time, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs and differentiation.	Ecdysone	221-229	tramtrack	Drosophila melanogaster	123-126
18779369-7	2008	Our results reveal a developmental pathway that includes down-regulation of Notch, activation of the EcR, up-regulation of Ttk to execute the E/A switch, and, for the first time, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs and differentiation.	Ecdysone	221-229	Notch	Drosophila melanogaster	211-216
18695041-4	2008	In this study, we identify a novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), that is involved in ecdysone-mediated transcription.	Ecdysone	148-156	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	45-86
18695041-4	2008	In this study, we identify a novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), that is involved in ecdysone-mediated transcription.	Ecdysone	148-156	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	88-92
18695041-4	2008	In this study, we identify a novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), that is involved in ecdysone-mediated transcription.	Ecdysone	148-156	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	122-125
18695041-5	2008	dLKR/SDH binds histones H3 and H4 and suppresses ecdysone-mediated transcription of cell death genes by inhibiting histone H3R17me2 mediated by the Drosophila arginine methyl transferase CARMER.	Ecdysone	49-57	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	0-4
18695041-5	2008	dLKR/SDH binds histones H3 and H4 and suppresses ecdysone-mediated transcription of cell death genes by inhibiting histone H3R17me2 mediated by the Drosophila arginine methyl transferase CARMER.	Ecdysone	49-57	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	5-8
18599591-6	2008	Using the ecdysone-inducible gene expression system, we expressed humanized cardiomyocyte-specific dominant-negative ErbB-1 mutant receptors (hErbB-1-mut) in young adult mice that block endogenous cardiac ErbB-1 signaling.	Ecdysone	10-18	epidermal growth factor receptor	Mus musculus	117-121
18599591-6	2008	Using the ecdysone-inducible gene expression system, we expressed humanized cardiomyocyte-specific dominant-negative ErbB-1 mutant receptors (hErbB-1-mut) in young adult mice that block endogenous cardiac ErbB-1 signaling.	Ecdysone	10-18	epidermal growth factor receptor	Mus musculus	143-147
18606996-2	2008	In flies and moths, molting is mediated by a heterodimer ecdysone receptor consisting of the ecdysone monomer (EcR) and an RXR homolog, ultraspiracle (USP); the latter is believed to have diverged from its RXR origin.	Ecdysone	57-65	retinoid X receptor alpha	Homo sapiens	123-126
18606996-2	2008	In flies and moths, molting is mediated by a heterodimer ecdysone receptor consisting of the ecdysone monomer (EcR) and an RXR homolog, ultraspiracle (USP); the latter is believed to have diverged from its RXR origin.	Ecdysone	57-65	retinoid X receptor alpha	Homo sapiens	206-209
18330897-7	2008	These results suggest that ubiquitous overexpression of HmgD results in the failure of pupariation neither by affecting the process of ecdysone synthesis and release nor by abnormal EcR transcription, but by causing expression of EcR regulatory nuclear receptors out of schedule.	Ecdysone	135-143	High mobility group protein D	Drosophila melanogaster	56-60
18430421-1	2008	Drosophila ecdysone-induced protein 78 (E78) belongs to the nuclear receptor (NR) superfamily, it plays a role directly related to ecdysone signaling.	Ecdysone	11-19	Ecdysone-induced protein 78C	Drosophila melanogaster	40-43
18481089-9	2008	Interestingly, Hth accumulates at high levels in some of the most prominent hormone-induced chromosomal puffs, pointing to a possible role of Hth in activation of ecdysone-induced targets.	Ecdysone	163-171	homothorax	Drosophila melanogaster	15-18
18481089-9	2008	Interestingly, Hth accumulates at high levels in some of the most prominent hormone-induced chromosomal puffs, pointing to a possible role of Hth in activation of ecdysone-induced targets.	Ecdysone	163-171	homothorax	Drosophila melanogaster	142-145
18550751-3	2008	To identify ecdysone-dependent gene expression changes in MB gamma neurons at the onset of axon pruning, we use laser capture microdissection to isolate wild-type and mutant MB neurons in which EcR (ecdysone receptor) activity is genetically blocked, and analyze expression changes by microarray.	Ecdysone	12-20	Ecdysone receptor	Drosophila melanogaster	194-197
18600068-4	2008	Using an ecdysone-inducible mammalian expression system, we demonstrate that the extent of cell death in 293-HtrA2 cells was approximately 20 times higher under Tm-induced ER stress, indicating that the increase in the HtrA2 protein level in the mitochondria itself is necessary but not sufficient for the promotion of cell death.	Ecdysone	9-17	HtrA serine peptidase 2	Homo sapiens	109-114
18600068-4	2008	Using an ecdysone-inducible mammalian expression system, we demonstrate that the extent of cell death in 293-HtrA2 cells was approximately 20 times higher under Tm-induced ER stress, indicating that the increase in the HtrA2 protein level in the mitochondria itself is necessary but not sufficient for the promotion of cell death.	Ecdysone	9-17	HtrA serine peptidase 2	Homo sapiens	219-224
17761811-7	2007	miR-14 plays a key role in modulating the positive autoregulatory loop by which Ecdysone sensitizes its own signaling pathway.	Ecdysone	80-88	mir-14 stem loop	Drosophila melanogaster	0-6
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysone	164-178	integument esterase 1	Bombyx mori	76-79
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysone	164-178	integument esterase 1	Bombyx mori	138-141
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysone	170-178	integument esterase 1	Bombyx mori	76-79
17658648-2	2007	A transient expression experiment using BmN cells and a series of truncated ie1 promoter constructs demonstrated that the activity of the ie1 promoter responded to alpha-ecdysone and 20-hydroxyecdysone, which required a tridecameric nucleotide stretch (ie1EcRE, 5"-GTGTTATCGACCT-3") homologous to the ecdysone response element reported for Drosophila (DmEcRE).	Ecdysone	170-178	integument esterase 1	Bombyx mori	138-141
17658648-3	2007	RT-PCR demonstrated the expression of BmEcR and BmUSP, which are required as ecdysone-specific activators for EcRE-mediated activation, in BmN cells.	Ecdysone	77-85	ecdysone receptor	Bombyx mori	38-43
17562531-12	2007	Thus, although KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling.	Ecdysone	136-144	Kruppel homolog 1	Drosophila melanogaster	15-20
17785192-2	2007	In Drosophila melanogaster Cyp307a1 (spook) and Cyp307a2 (spookier) both play essential roles in ecdysone synthesis and may possess biochemically redundant functions.	Ecdysone	97-105	spook	Drosophila melanogaster	27-35
17785192-2	2007	In Drosophila melanogaster Cyp307a1 (spook) and Cyp307a2 (spookier) both play essential roles in ecdysone synthesis and may possess biochemically redundant functions.	Ecdysone	97-105	spook	Drosophila melanogaster	37-42
17785192-2	2007	In Drosophila melanogaster Cyp307a1 (spook) and Cyp307a2 (spookier) both play essential roles in ecdysone synthesis and may possess biochemically redundant functions.	Ecdysone	97-105	spookier	Drosophila melanogaster	48-56
18061567-2	2007	Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis.	Ecdysone	125-133	Prothoracicotropic hormone	Drosophila melanogaster	0-26
18061567-2	2007	Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis.	Ecdysone	125-133	Prothoracicotropic hormone	Drosophila melanogaster	28-32
17923694-0	2007	Drosophila Blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway.	Ecdysone	88-96	Blimp-1	Drosophila melanogaster	11-18
17923694-8	2007	These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.	Ecdysone	133-141	Blimp-1	Drosophila melanogaster	67-75
17948312-4	2007	Hypomorphic dTrf2 mutations lead to developmental arrest during prepupal and early pupal stages with defects in major ecdysone-triggered biological responses, including puparium formation, anterior spiracle eversion, gas bubble translocation, adult head eversion, and larval salivary gland cell death.	Ecdysone	118-126	TATA box binding protein-related factor 2	Drosophila melanogaster	12-17
18059550-1	2007	The DOPA decarboxylase gene (Ddc) belongs to the "early-late" class of ecdysone-inducible genes in Drosophila melanogaster.	Ecdysone	71-79	Dopa decarboxylase	Drosophila melanogaster	4-22
18059550-1	2007	The DOPA decarboxylase gene (Ddc) belongs to the "early-late" class of ecdysone-inducible genes in Drosophila melanogaster.	Ecdysone	71-79	Dopa decarboxylase	Drosophila melanogaster	29-32
17899014-3	2007	We have used an ecdysone-inducible NOP expression system in a CHO line (CHO INDhNOP) to examine the effects of N/OFQ pretreatment upon receptor density, GTPgamma[35S] binding, cAMP formation and NOP-mRNA.	Ecdysone	16-24	opioid related nociceptin receptor 1	Homo sapiens	35-38
17651473-10	2007	Using cultured ovary cell line, BmN-SWU1, we examined the effect of altered ecdysone levels on bmo-let-7 expression.	Ecdysone	76-84	Mirlet7	Bombyx mori	95-104
17679695-4	2007	In Drosophila, the salivary gland is sculpted by caspase-mediated programmed cell death initiated by the steroid hormone 20-hydroxyecdysone (ecdysone).	Ecdysone	131-139	Death caspase-1	Drosophila melanogaster	49-56
17679695-8	2007	In contrast to the in vivo response, the salivary glands from betaFTZ-F1 mutants showed a normal in vitro response to ecdysone, suggesting that betaFTZ-F1 may be involved in ecdysteroid biosynthesis and secretion of ecdysone from the ring gland for local initiation of programmed cell death.	Ecdysone	118-126	ftz transcription factor 1	Drosophila melanogaster	62-72
17679695-8	2007	In contrast to the in vivo response, the salivary glands from betaFTZ-F1 mutants showed a normal in vitro response to ecdysone, suggesting that betaFTZ-F1 may be involved in ecdysteroid biosynthesis and secretion of ecdysone from the ring gland for local initiation of programmed cell death.	Ecdysone	216-224	ftz transcription factor 1	Drosophila melanogaster	62-72
17679695-8	2007	In contrast to the in vivo response, the salivary glands from betaFTZ-F1 mutants showed a normal in vitro response to ecdysone, suggesting that betaFTZ-F1 may be involved in ecdysteroid biosynthesis and secretion of ecdysone from the ring gland for local initiation of programmed cell death.	Ecdysone	216-224	ftz transcription factor 1	Drosophila melanogaster	144-154
17899820-1	2007	The effect of various duration of heat stress (38 degrees C) on the activity of ecdysone 20-monooxygenase converting ecdysone into 20-hydroxyecdysone has been studied in D. virilis of wild type and mutant strain females, which differ by the mode of heat stress response of ecdysone and 20-hydroxyecdysone.	Ecdysone	117-125	shade	Drosophila melanogaster	80-105
17591924-1	2007	A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death.	Ecdysone	31-39	reaper	Drosophila melanogaster	183-186
17591924-3	2007	We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1).	Ecdysone	103-111	nejire	Drosophila melanogaster	13-16
17591924-3	2007	We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1).	Ecdysone	103-111	nejire	Drosophila melanogaster	124-127
17591924-3	2007	We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1).	Ecdysone	103-111	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	183-218
17591924-3	2007	We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1).	Ecdysone	103-111	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	220-225
17239346-0	2007	Ecdysone induction of MsrA protects against oxidative stress in Drosophila.	Ecdysone	0-8	Methionine sulfoxide reductase A	Drosophila melanogaster	22-26
17373718-2	2007	The RheoSwitch system employs RheoSwitch Ligand 1 (RSL1), a non-steroidal analog of the insect hormone ecdysone, to activate a modified nuclear receptor heterodimer that controls target gene expression via GAL4 response elements.	Ecdysone	103-111	galectin 4	Homo sapiens	206-210
17381843-7	2007	By contrast, all the five Drosophila P450s (CYP302A1, CYP306A1, CYP307A1, CYP314A1 and CYP315A1) involved in ecdysone biosynthesis and developmental regulation are free of TE insertions.	Ecdysone	109-117	disembodied	Drosophila melanogaster	44-52
17381843-7	2007	By contrast, all the five Drosophila P450s (CYP302A1, CYP306A1, CYP307A1, CYP314A1 and CYP315A1) involved in ecdysone biosynthesis and developmental regulation are free of TE insertions.	Ecdysone	109-117	phantom	Drosophila melanogaster	54-62
17381843-7	2007	By contrast, all the five Drosophila P450s (CYP302A1, CYP306A1, CYP307A1, CYP314A1 and CYP315A1) involved in ecdysone biosynthesis and developmental regulation are free of TE insertions.	Ecdysone	109-117	spook	Drosophila melanogaster	64-72
17381843-7	2007	By contrast, all the five Drosophila P450s (CYP302A1, CYP306A1, CYP307A1, CYP314A1 and CYP315A1) involved in ecdysone biosynthesis and developmental regulation are free of TE insertions.	Ecdysone	109-117	shade	Drosophila melanogaster	74-82
17381843-7	2007	By contrast, all the five Drosophila P450s (CYP302A1, CYP306A1, CYP307A1, CYP314A1 and CYP315A1) involved in ecdysone biosynthesis and developmental regulation are free of TE insertions.	Ecdysone	109-117	shadow	Drosophila melanogaster	87-95
17322404-1	2007	Expression of the Drosophila orphan nuclear receptor DHR78 is regulated by the steroid hormone ecdysone and is required for growth and viability during larval stages.	Ecdysone	95-103	Hormone-receptor-like in 78	Drosophila melanogaster	53-58
17073797-5	2006	phm, dib and sad, which encode P450s that mediate the final hydroxylations in the biosynthesis of ecdysone, were selectively expressed in the prothoracic gland, the primary source of ecdysone during larval and pupal development.	Ecdysone	98-106	phantom	Drosophila melanogaster	0-3
17073797-5	2006	phm, dib and sad, which encode P450s that mediate the final hydroxylations in the biosynthesis of ecdysone, were selectively expressed in the prothoracic gland, the primary source of ecdysone during larval and pupal development.	Ecdysone	183-191	phantom	Drosophila melanogaster	0-3
17201771-5	2006	A mutation, K497E, in the shared ligand-binding domain of the EcR isoforms caused elevated EcRB2-specific affinity for a canonical ecdysone response element.	Ecdysone	131-139	Ecdysone receptor	Drosophila melanogaster	62-65
16876710-4	2006	Cyp6d5, Cyp6w1, Cyp12d1 and the ecdysone-inducible Cyp6a2 were induced by both chemicals.	Ecdysone	32-40	Cytochrome P450-6a2	Drosophila melanogaster	51-57
16741927-4	2006	Here we provide the first demonstration that the conditional expression of AML1-ETO by the ecdysone-inducible system dramatically increases the expression of connexin 43 (CX43), together with growth arrest at G1 phase in leukemic U937 cells.	Ecdysone	91-99	RUNX family transcription factor 1	Homo sapiens	75-79
16741927-4	2006	Here we provide the first demonstration that the conditional expression of AML1-ETO by the ecdysone-inducible system dramatically increases the expression of connexin 43 (CX43), together with growth arrest at G1 phase in leukemic U937 cells.	Ecdysone	91-99	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	80-83
16741927-4	2006	Here we provide the first demonstration that the conditional expression of AML1-ETO by the ecdysone-inducible system dramatically increases the expression of connexin 43 (CX43), together with growth arrest at G1 phase in leukemic U937 cells.	Ecdysone	91-99	gap junction protein alpha 1	Homo sapiens	158-169
16741927-4	2006	Here we provide the first demonstration that the conditional expression of AML1-ETO by the ecdysone-inducible system dramatically increases the expression of connexin 43 (CX43), together with growth arrest at G1 phase in leukemic U937 cells.	Ecdysone	91-99	gap junction protein alpha 1	Homo sapiens	171-175
16990270-8	2006	We found the hormone-responsive Ecdysone-induced genes (Eig) were strongly misregulated and that the Brm complex is directly associated with the promoter regions of these genes in vivo.	Ecdysone	32-40	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	101-104
16949568-0	2006	Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera.	Ecdysone	61-69	spook	Drosophila melanogaster	0-5
16949568-4	2006	In contrast, we show here that several dipteran genomes encode two novel, highly related, microsomal P450 enzymes, Cyp307A1 and Cyp307A2, that likely participate as stage-specific components of the ecdysone biosynthetic machinery.	Ecdysone	198-206	spook	Drosophila melanogaster	115-123
16949568-4	2006	In contrast, we show here that several dipteran genomes encode two novel, highly related, microsomal P450 enzymes, Cyp307A1 and Cyp307A2, that likely participate as stage-specific components of the ecdysone biosynthetic machinery.	Ecdysone	198-206	spookier	Drosophila melanogaster	128-136
16949568-8	2006	In addition, spok expression is eliminated in larvae carrying mutations in molting defective (mld), a gene encoding a nuclear zinc finger protein that is required for production of ecdysone during Drosophila larval development.	Ecdysone	181-189	spookier	Drosophila melanogaster	13-17
16874068-5	2006	Downregulation of the PI3K pathway could be restored by feeding the dor mutants with ecdysone.	Ecdysone	85-93	deep orange	Drosophila melanogaster	68-71
16874068-8	2006	In this Addendum we review these findings and provide some speculations about how Dor may control both ecdysone signalling and autolysosomal fusion.	Ecdysone	103-111	deep orange	Drosophila melanogaster	82-85
16600212-7	2006	In the present report, we have tested the hypothesis that Dor may control programmed autophagy at the level of ecdysone signaling as well as by mediating autophagosome-to-lysosome fusion.	Ecdysone	111-119	deep orange	Drosophila melanogaster	58-61
16763204-5	2006	nvd is expressed specifically in tissues that synthesize ecdysone, such as the PG.	Ecdysone	57-65	neverland	Drosophila melanogaster	0-3
16547226-3	2006	We investigated the dose-dependent effects of endogenously produced NO on apoptosis using ecdysone-inducible NOS2 cell lines.	Ecdysone	90-98	nitric oxide synthase 2	Homo sapiens	109-113
15979280-16	2006	First, we used a human U87MG glioblastoma PTEN-null cell line that hosts an ecdysone-inducible PTEN expression system.	Ecdysone	76-84	phosphatase and tensin homolog	Homo sapiens	42-46
15979280-16	2006	First, we used a human U87MG glioblastoma PTEN-null cell line that hosts an ecdysone-inducible PTEN expression system.	Ecdysone	76-84	phosphatase and tensin homolog	Homo sapiens	95-99
15987944-3	2005	Here, we describe the activation of a novel, neuronally expressed Drosophila GPCR by the insect ecdysteroids ecdysone (E) and 20-hydroxyecdysone (20E).	Ecdysone	109-117	Octopamine receptor in mushroom bodies	Drosophila melanogaster	77-81
16504006-4	2006	RESULTS: To underscore this sensitivity, we showed that a widely used system of transcriptional induction involving ecdysone (muristerone) led to sufficient expression of hTERT to immortalize human fibroblasts, even in the absence of induction.	Ecdysone	116-124	telomerase reverse transcriptase	Homo sapiens	171-176
16325168-0	2005	Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone.	Ecdysone	107-115	Myocyte enhancer factor 2	Drosophila melanogaster	17-42
16325168-1	2005	The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively small number of immediate-early genes during Drosophila pupal development, yet is able to orchestrate distinct differentiation events in a wide variety of tissues.	Ecdysone	30-38	Partner of Bursicon	Drosophila melanogaster	129-134
16271526-1	2005	In the fruit fly Drosophila melanogaster, the insulin and ecdysone signaling pathways have long been known to regulate growth and developmental timing, respectively.	Ecdysone	58-66	Insulin-like receptor	Drosophila melanogaster	46-53
16182526-6	2005	We found that the activation of Ras within the PG induces precocious ecdysone release, whereas expression of either dn-PI3K or dn-Raf in the PG greatly attenuates the [ecdysone] increase that causes growth cessation and pupariation onset.	Ecdysone	168-176	Raf oncogene	Drosophila melanogaster	130-133
16182526-8	2005	We also suggest that ecdysone release is regulated in two ways: a PI3K-dependent growth-promoting effect on PG cells, and a Raf-dependent step that may involve the transcriptional regulation of ecdysone biosynthetic genes.	Ecdysone	21-29	Raf oncogene	Drosophila melanogaster	124-127
16182526-8	2005	We also suggest that ecdysone release is regulated in two ways: a PI3K-dependent growth-promoting effect on PG cells, and a Raf-dependent step that may involve the transcriptional regulation of ecdysone biosynthetic genes.	Ecdysone	194-202	Raf oncogene	Drosophila melanogaster	124-127
15813704-4	2005	When CG9504 was expressed in COS7 cells, significant conversion of ecdysone into 3-dehydroecdysone was observed.	Ecdysone	67-75	Ecdysone oxidase	Drosophila melanogaster	5-11
16045756-1	2005	Prothoracicotropic hormone (PTTH) plays a central role in controlling molting, metamorphosis, and diapause termination in insects by stimulating the prothoracic glands to synthesize and release the molting hormone, ecdysone.	Ecdysone	215-223	prothoracicotropic hormone	Bombyx mori	0-26
16045756-1	2005	Prothoracicotropic hormone (PTTH) plays a central role in controlling molting, metamorphosis, and diapause termination in insects by stimulating the prothoracic glands to synthesize and release the molting hormone, ecdysone.	Ecdysone	215-223	prothoracicotropic hormone	Bombyx mori	28-32
15930518-1	2005	The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.	Ecdysone	105-113	ATP binding cassette subfamily A member 1	Homo sapiens	130-135
15930518-1	2005	The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.	Ecdysone	105-113	ATP binding cassette subfamily A member 7	Homo sapiens	145-150
16002547-2	2005	To explore further the role of Cdx-2 in regulating both insulin and proglucagon gene expression, we established an ecdysone-inducible Cdx-2 expression system.	Ecdysone	115-123	caudal type homeo box 2	Rattus norvegicus	31-36
16002547-2	2005	To explore further the role of Cdx-2 in regulating both insulin and proglucagon gene expression, we established an ecdysone-inducible Cdx-2 expression system.	Ecdysone	115-123	caudal type homeo box 2	Rattus norvegicus	134-139
15922568-3	2005	Expression of the Drosophila caspase-9 homolog, DRONC, can be induced by ecdysone, a steroid hormone, which induces metamorphosis.	Ecdysone	73-81	Death regulator Nedd2-like caspase	Drosophila melanogaster	29-38
15922568-3	2005	Expression of the Drosophila caspase-9 homolog, DRONC, can be induced by ecdysone, a steroid hormone, which induces metamorphosis.	Ecdysone	73-81	Death regulator Nedd2-like caspase	Drosophila melanogaster	48-53
16503480-0	2006	Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta.	Ecdysone	113-121	Cyp6a9-rAF4-2	Drosophila melanogaster	90-94
16082389-0	2006	Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.	Ecdysone	15-23	Fas ligand	Homo sapiens	70-80
16082389-0	2006	Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.	Ecdysone	15-23	TNF superfamily member 10	Homo sapiens	86-91
16313897-6	2006	Pdp1(p205) larvae also appear to have normal muscle and gut function and respond to ecdysone.	Ecdysone	84-92	PAR-domain protein 1	Drosophila melanogaster	0-4
16079224-0	2006	Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.	Ecdysone	54-62	Niemann-Pick type C-1a	Drosophila melanogaster	26-30
16188237-0	2005	Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects.	Ecdysone	48-56	spook	Drosophila melanogaster	16-24
16188237-0	2005	Cytochrome P450 CYP307A1/Spook: a regulator for ecdysone synthesis in insects.	Ecdysone	48-56	spook	Drosophila melanogaster	25-30
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	121-129	spook	Drosophila melanogaster	24-32
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	121-129	spook	Drosophila melanogaster	51-56
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	121-129	spook	Drosophila melanogaster	161-169
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	185-193	spook	Drosophila melanogaster	24-32
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	185-193	spook	Drosophila melanogaster	51-56
16188237-5	2005	In addition, Drosophila Cyp307a1 is encoded in the spook locus, one of the Halloween mutant family members showing a low ecdysone titer in vivo, suggesting that Cyp307a1 is involved in ecdysone synthesis.	Ecdysone	185-193	spook	Drosophila melanogaster	161-169
16221727-9	2005	Ring gland-specific expression of dnpc1a in otherwise mutant flies allowed development to adulthood, suggesting that the lack of ecdysone in the mutants is the cause of death.	Ecdysone	129-137	Niemann-Pick type C-1a	Drosophila melanogaster	34-40
16221727-10	2005	We propose that dnpc1a mutants have sterols trapped in aberrant organelles, leading to a shortage of sterol in the endoplasmic reticulum and/or mitochondria of ring gland cells, and, consequently, inadequate ecdysone synthesis.	Ecdysone	208-216	Niemann-Pick type C-1a	Drosophila melanogaster	16-22
16243018-1	2005	New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth.	Ecdysone	126-134	Insulin-like receptor	Drosophila melanogaster	51-58
15950604-3	2005	EcR-A and EcR-B1 are expressed in a spatially complementary pattern at the onset of metamorphosis, suggesting that specific responses to ecdysone involve distinct EcR isoforms.	Ecdysone	137-145	Ecdysone receptor	Drosophila melanogaster	0-3
15922568-9	2005	Our study places DRONC at a central point of convergence for multiple cell death pathways and for the ecdysone pathway regulating metamorphosis.	Ecdysone	102-110	Death regulator Nedd2-like caspase	Drosophila melanogaster	17-22
15735678-8	2005	Functional assays with ecdysone-inducible cell lines revealed that Hugl-1 expression increased cell adhesion and decreased cell migration.	Ecdysone	23-31	LLGL scribble cell polarity complex component 1	Homo sapiens	67-73
15935763-0	2005	The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila.	Ecdysone	4-12	Hormone receptor 4	Drosophila melanogaster	21-25
15935763-4	2005	In addition, we show that DHR4 plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the betaFTZ-F1 midprepupal competence factor.	Ecdysone	109-117	Hormone receptor 4	Drosophila melanogaster	26-30
15935763-4	2005	In addition, we show that DHR4 plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the betaFTZ-F1 midprepupal competence factor.	Ecdysone	109-117	ftz transcription factor 1	Drosophila melanogaster	245-255
15657059-0	2005	Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.	Ecdysone	0-8	Death related ICE-like caspase	Drosophila melanogaster	56-61
15661647-2	2005	The Kr-h gene of Drosophila is a modulator of both the embryonic and metamorphic hierarchies of ecdysone responsive genes, but its mode of action is puzzling as mutants have both quantitative and qualitative (timing) effects on the ecdysone responses.	Ecdysone	96-104	Kruppel homolog 1	Drosophila melanogaster	4-8
15950604-1	2005	The steroid hormone ecdysone triggers transitions between developmental stages in Drosophila by acting through a heterodimer consisting of the EcR and USP nuclear receptors.	Ecdysone	20-28	Ecdysone receptor	Drosophila melanogaster	143-146
15950604-3	2005	EcR-A and EcR-B1 are expressed in a spatially complementary pattern at the onset of metamorphosis, suggesting that specific responses to ecdysone involve distinct EcR isoforms.	Ecdysone	137-145	Ecdysone receptor	Drosophila melanogaster	0-5
15950604-3	2005	EcR-A and EcR-B1 are expressed in a spatially complementary pattern at the onset of metamorphosis, suggesting that specific responses to ecdysone involve distinct EcR isoforms.	Ecdysone	137-145	Ecdysone receptor	Drosophila melanogaster	10-16
15661647-2	2005	The Kr-h gene of Drosophila is a modulator of both the embryonic and metamorphic hierarchies of ecdysone responsive genes, but its mode of action is puzzling as mutants have both quantitative and qualitative (timing) effects on the ecdysone responses.	Ecdysone	232-240	Kruppel homolog 1	Drosophila melanogaster	4-8
15489901-4	2004	We used an ecdysone-inducible expression system in the human monoblastic U-937 cell line to isolate genes that were differentially expressed upon induction of AML1/ETO expression.	Ecdysone	11-19	RUNX family transcription factor 1	Homo sapiens	159-163
15810609-6	2005	It is supposed that the overexpression of the tth gene causes either a shift in the ecdysterone-to-JH ratio (through a decreased JH decay rate or a delayed initiation of ecdysone synthesis) or a deceleration of the release of ecdysterones synthesized.	Ecdysone	170-178	toothrin	Drosophila melanogaster	46-49
15489901-4	2004	We used an ecdysone-inducible expression system in the human monoblastic U-937 cell line to isolate genes that were differentially expressed upon induction of AML1/ETO expression.	Ecdysone	11-19	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	164-167
15363856-2	2004	One of the early genes, Broad-Complex (BR-C), a key regulator of the ecdysone cascade, shares a common amino-terminal BTB domain which is fused by alternative splicing to one of four pairs of C(2)H(2) zinc finger domains (Z1, Z2, Z3, and Z4).	Ecdysone	69-77	broad-complex	Bombyx mori	39-43
15544943-3	2004	By RT-PCR and RNAi experiments, we identified gp150 as the previously described I71-7, an ecdysone-induced salivary glue protein.	Ecdysone	90-98	Gp150	Drosophila melanogaster	46-51
15544943-3	2004	By RT-PCR and RNAi experiments, we identified gp150 as the previously described I71-7, an ecdysone-induced salivary glue protein.	Ecdysone	90-98	Ecdysone-induced gene 71Ee	Drosophila melanogaster	80-85
15026169-5	2004	A third enzyme, necessary for the critical conversion of ecdysone to 20-hydroxyecdysone, the 20-monooxygenase, is encoded by shade (shd) (CYP314A1).	Ecdysone	57-65	shade	Drosophila melanogaster	138-146
15197185-9	2004	The morphological defects and decreased expression of ecdysone-inducible genes in phm suggest that this mutant cannot produce a high titer of ecdysone.	Ecdysone	54-62	phantom	Drosophila melanogaster	82-85
15197185-9	2004	The morphological defects and decreased expression of ecdysone-inducible genes in phm suggest that this mutant cannot produce a high titer of ecdysone.	Ecdysone	142-150	phantom	Drosophila melanogaster	82-85
15207731-3	2004	As Drosophila poly(ADP-ribose) polymerase (dPARP) has recently been reported to be involved in ecdysone-induced puff formation, we decided to test the possible role of dPARP in ligand-induced dEcR transactivation in an insect system.	Ecdysone	95-103	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	14-41
15207731-3	2004	As Drosophila poly(ADP-ribose) polymerase (dPARP) has recently been reported to be involved in ecdysone-induced puff formation, we decided to test the possible role of dPARP in ligand-induced dEcR transactivation in an insect system.	Ecdysone	95-103	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	43-48
15173191-4	2004	DRONC, the Drosophila initiator caspase, is transcriptionally regulated by ecdysone during development.	Ecdysone	75-83	Death regulator Nedd2-like caspase	Drosophila melanogaster	0-5
15150408-3	2004	We show here that ecdysone-induced expression of the death activator genes reaper (rpr) and head involution defective (hid) is required for destruction of the larval midgut and salivary glands during metamorphosis, with hid playing a primary role in the salivary glands and rpr and hid acting in a redundant manner in the midguts.	Ecdysone	18-26	head involution defective	Drosophila melanogaster	119-122
15150408-3	2004	We show here that ecdysone-induced expression of the death activator genes reaper (rpr) and head involution defective (hid) is required for destruction of the larval midgut and salivary glands during metamorphosis, with hid playing a primary role in the salivary glands and rpr and hid acting in a redundant manner in the midguts.	Ecdysone	18-26	head involution defective	Drosophila melanogaster	220-223
15150408-3	2004	We show here that ecdysone-induced expression of the death activator genes reaper (rpr) and head involution defective (hid) is required for destruction of the larval midgut and salivary glands during metamorphosis, with hid playing a primary role in the salivary glands and rpr and hid acting in a redundant manner in the midguts.	Ecdysone	18-26	head involution defective	Drosophila melanogaster	220-223
15170054-5	2004	In de novo biosynthesis of 20E in B. mori eggs, hydroxylation at the C-20 position of ecdysone, which is catalyzed by ecdysone 20-hydroxylase, is a rate-limiting step.	Ecdysone	86-94	ecdysone 20-hydroxylase	Bombyx mori	118-141
15189568-7	2004	A lethal mutation, swit476, shows a severe disruption of the ecdysone pathway and is a C>Y substitution in one of the two conserved CysXCys motifs that are common to SWI and the Drosophila Toll-4 protein.	Ecdysone	61-69	halfway	Drosophila melanogaster	169-172
15189568-7	2004	A lethal mutation, swit476, shows a severe disruption of the ecdysone pathway and is a C>Y substitution in one of the two conserved CysXCys motifs that are common to SWI and the Drosophila Toll-4 protein.	Ecdysone	61-69	Toll-4	Drosophila melanogaster	192-198
15189568-8	2004	CONCLUSIONS: It is not entirely clear from the present molecular analysis how the SWI protein may function in the ecdysone induced cascade.	Ecdysone	114-122	halfway	Drosophila melanogaster	82-85
14976192-0	2004	An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells.	Ecdysone	59-67	Arginine methyltransferase 4	Drosophila melanogaster	39-45
14976192-4	2004	Here we show that CARMER, an arginine-histone methyltransferase, is critical in coordinating ecdysone-induced expression of Drosophila cell death genes.	Ecdysone	93-101	Arginine methyltransferase 4	Drosophila melanogaster	18-24
14976192-5	2004	Ablation of CARMER blocks ecdysone-induced cell death in Drosophila cells, but not apoptosis induced by cell stress.	Ecdysone	26-34	Arginine methyltransferase 4	Drosophila melanogaster	12-18
14742717-3	2004	We have created an ecdysone-inducible gene expression system in the INS-1 beta-cell line and find that induced expression of a membrane-anchorless, cytosolic Syn6 (called Syn6t), but not full-length Syn6, causes a prominent defect in endosomal delivery to lysosomes, and the TGN, in these cells.	Ecdysone	19-27	syntaxin 6	Rattus norvegicus	158-162
14742717-3	2004	We have created an ecdysone-inducible gene expression system in the INS-1 beta-cell line and find that induced expression of a membrane-anchorless, cytosolic Syn6 (called Syn6t), but not full-length Syn6, causes a prominent defect in endosomal delivery to lysosomes, and the TGN, in these cells.	Ecdysone	19-27	syntaxin 6	Rattus norvegicus	171-176
14742717-3	2004	We have created an ecdysone-inducible gene expression system in the INS-1 beta-cell line and find that induced expression of a membrane-anchorless, cytosolic Syn6 (called Syn6t), but not full-length Syn6, causes a prominent defect in endosomal delivery to lysosomes, and the TGN, in these cells.	Ecdysone	19-27	syntaxin 6	Rattus norvegicus	171-175
14731262-0	2004	Ecdysone agonist-inducible expression of a coat protein gene from tobacco mosaic virus confers viral resistance in transgenic Arabidopsis.	Ecdysone	0-8	Coat protein	Tobacco mosaic virus	43-55
15026367-4	2004	Induction of IGFBP-3 using an ecdysone-inducible expression system inhibited DNA synthesis in an IGF-IGF receptor axis-independent fashion and resulted in the subsequent induction of apoptosis and an increase in caspase activity.	Ecdysone	30-38	insulin like growth factor binding protein 3	Homo sapiens	13-20
14972681-0	2004	Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis.	Ecdysone	35-43	LIM domain kinase 1	Drosophila melanogaster	4-14
14972681-4	2004	We have established a link between Rho-LIMK-SRF signaling and the ecdysone-induced transcriptional response during Drosophila development.	Ecdysone	66-74	LIM domain kinase 1	Drosophila melanogaster	39-43
14972681-4	2004	We have established a link between Rho-LIMK-SRF signaling and the ecdysone-induced transcriptional response during Drosophila development.	Ecdysone	66-74	Srf	Drosophila melanogaster	44-47
14972681-7	2004	In cultured SL2 cells, inhibition of Rho, F-actin assembly, or SRF blocks the transcriptional response to ecdysone.	Ecdysone	106-114	Actin 42A	Drosophila melanogaster	42-49
14972681-7	2004	In cultured SL2 cells, inhibition of Rho, F-actin assembly, or SRF blocks the transcriptional response to ecdysone.	Ecdysone	106-114	Srf	Drosophila melanogaster	63-66
14758223-7	2004	HEK-293 cells were transfected with human NGF cDNA with the ecdysone-inducible mammalian expression system (Invitrogen, Carlsbad, Calif.).	Ecdysone	60-68	nerve growth factor	Homo sapiens	42-45
14687985-4	2003	Transient transfectants of B-, T-, epithelial and 3T3 cells, and stable transfectants with ecdysone-inducible LMP1 expression were produced.	Ecdysone	91-99	PDZ and LIM domain 7	Homo sapiens	110-114
14645129-3	2004	We describe a novel nuclear receptor interacting protein encoded by rigor mortis (rig) that is required for ecdysone responses during larval development.	Ecdysone	108-116	rigor mortis	Drosophila melanogaster	68-71
12816867-2	2003	To assess the role of p18 Bax in apoptosis, an ecdysone-inducible expression system was generated.	Ecdysone	47-55	H3 histone pseudogene 12	Homo sapiens	22-25
14603321-10	2003	Mutations in trr interact in eye development with EcR, and EcR and TRR can be co-immunoprecipitated on ecdysone treatment.	Ecdysone	103-111	trithorax-related	Drosophila melanogaster	13-16
14603321-10	2003	Mutations in trr interact in eye development with EcR, and EcR and TRR can be co-immunoprecipitated on ecdysone treatment.	Ecdysone	103-111	Ecdysone receptor	Drosophila melanogaster	59-62
14603321-10	2003	Mutations in trr interact in eye development with EcR, and EcR and TRR can be co-immunoprecipitated on ecdysone treatment.	Ecdysone	103-111	trithorax-related	Drosophila melanogaster	67-70
14603321-12	2003	We propose that TRR functions as a coactivator of EcR by altering the chromatin structure at ecdysone-responsive promoters.	Ecdysone	93-101	trithorax-related	Drosophila melanogaster	16-19
14603321-12	2003	We propose that TRR functions as a coactivator of EcR by altering the chromatin structure at ecdysone-responsive promoters.	Ecdysone	93-101	Ecdysone receptor	Drosophila melanogaster	50-53
14668390-7	2003	Our findings suggest that ecdysone exerts its effects on leg morphogenesis through a Rho1 signaling cascade, a proposal that is supported by genetic interaction studies between the E(br) mutations and mutations in the Rho1 signaling pathway.	Ecdysone	26-34	Rho1	Drosophila melanogaster	85-89
14668390-7	2003	Our findings suggest that ecdysone exerts its effects on leg morphogenesis through a Rho1 signaling cascade, a proposal that is supported by genetic interaction studies between the E(br) mutations and mutations in the Rho1 signaling pathway.	Ecdysone	26-34	Rho1	Drosophila melanogaster	218-222
14668390-9	2003	Coupled with recent evidence implicating ecdysone signaling in these embryonic morphogenetic events, our results suggest that a common ecdysone-dependent, Rho1-mediated regulatory pathway controls morphogenesis during the two major transitions in the life cycle, embryogenesis and metamorphosis.	Ecdysone	41-49	Rho1	Drosophila melanogaster	155-159
14668390-9	2003	Coupled with recent evidence implicating ecdysone signaling in these embryonic morphogenetic events, our results suggest that a common ecdysone-dependent, Rho1-mediated regulatory pathway controls morphogenesis during the two major transitions in the life cycle, embryogenesis and metamorphosis.	Ecdysone	135-143	Rho1	Drosophila melanogaster	155-159
12816867-2	2003	To assess the role of p18 Bax in apoptosis, an ecdysone-inducible expression system was generated.	Ecdysone	47-55	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
12654933-4	2003	In order to gain further insight into the evolution of metamorphosis and gene regulation by ecdysone in arthropods, we performed a phylogenetic analysis of both partners of the heterodimer ECR/USP-RXR.	Ecdysone	92-100	retinoid X receptor alpha	Homo sapiens	197-200
12941617-4	2003	The insulin-related peptides of insects do not appear to control growth by themselves, but act in conjunction with other hormones and signaling molecules, such as ecdysone and IDGFs.	Ecdysone	163-171	insulin	Homo sapiens	4-11
12787397-11	2003	p27Kip1 expression was reconstituted in two different clones of p27Kip1-/- proximal tubular cells using an inducible vector system based on ecdysone response elements.	Ecdysone	140-148	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-7
12605879-4	2003	The mRNA level of the NR2B subunits in EcR/rNRa2B cells was dependent on the concentration of the ecdysone analogue inducing agent, muristerone A (MuA).	Ecdysone	98-106	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	22-26
12710964-2	2003	Our previous studies have supported the hypothesis that betaFTZ-F1 (an orphan nuclear receptor) provides specific genes with the competence to be induced by ecdysone at the appropriate time, thus directing key developmental events at the prepupal-pupal transition.	Ecdysone	157-165	ftz transcription factor 1	Drosophila melanogaster	56-66
14501191-5	2003	A transient expression assay showed that the product of this ORF was able to conjugate glucose from UDP-glucose with ecdysone confirming that the gene identified was indeed the SfMNPV egt gene.	Ecdysone	117-125	ecdysteroid UDP-glucosyltransferase	Spodoptera frugiperda multiple nucleopolyhedrovirus	184-187
12736135-0	2003	An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling.	Ecdysone	3-11	Rac family small GTPase 1	Canis lupus familiaris	78-82
12967935-0	2003	Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system.	Ecdysone	114-122	prepronociceptin	Homo sapiens	52-62
12967935-0	2003	Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system.	Ecdysone	114-122	opioid related nociceptin receptor 1	Homo sapiens	63-83
12967935-3	2003	We have utilised the ecdysone-inducible expression system containing the human nociceptin/orphanin FQ (N/OFQ) peptide receptor (hNOP) expressed in Chinese hamster ovary cells (CHOINDhNOP) to examine the activity of a range of partial agonists in receptor binding, GTPgamma35S binding and inhibition of adenylyl cyclase studies.	Ecdysone	21-29	prepronociceptin	Homo sapiens	79-89
12967935-3	2003	We have utilised the ecdysone-inducible expression system containing the human nociceptin/orphanin FQ (N/OFQ) peptide receptor (hNOP) expressed in Chinese hamster ovary cells (CHOINDhNOP) to examine the activity of a range of partial agonists in receptor binding, GTPgamma35S binding and inhibition of adenylyl cyclase studies.	Ecdysone	21-29	prepronociceptin	Homo sapiens	90-101
12967935-3	2003	We have utilised the ecdysone-inducible expression system containing the human nociceptin/orphanin FQ (N/OFQ) peptide receptor (hNOP) expressed in Chinese hamster ovary cells (CHOINDhNOP) to examine the activity of a range of partial agonists in receptor binding, GTPgamma35S binding and inhibition of adenylyl cyclase studies.	Ecdysone	21-29	opioid related nociceptin receptor 1	Homo sapiens	128-132
12812783-6	2003	Here, we ask whether the steroid hormone ecdysone induces let-7 or miR-125 expression at the onset of metamorphosis, attempting to link a known temporal regulator in Drosophila with the heterochronic pathway defined in C. elegans.	Ecdysone	41-49	let-7	Drosophila melanogaster	58-63
12812783-6	2003	Here, we ask whether the steroid hormone ecdysone induces let-7 or miR-125 expression at the onset of metamorphosis, attempting to link a known temporal regulator in Drosophila with the heterochronic pathway defined in C. elegans.	Ecdysone	41-49	mir-125 stem loop	Drosophila melanogaster	67-74
12674500-3	2003	It was demonstrated that the recombinant receptor specifically binds the ecdysone response element of the hsp27 gene promoter (hsp27EcRE).	Ecdysone	73-81	Heat shock protein 27	Drosophila melanogaster	106-111
12045184-0	2002	Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.	Ecdysone	0-8	Death caspase-1	Drosophila melanogaster	35-42
12407106-8	2002	Overexpression of cytochrome c enhances caspase activation and promotes cell death in response to apoptotic stimulation, but simple up-regulation of cytochrome c using an ecdysone-inducible system is, by itself, insufficient to induce apoptosis.	Ecdysone	171-179	cytochrome c, somatic	Homo sapiens	149-161
12453153-10	2002	The developmental arrest of dSec10 RNAi animals was partially rescued by feeding ecdysone, suggesting dSec10 mediates steroid hormone secretion.	Ecdysone	81-89	Secretory 10	Drosophila melanogaster	28-34
12453153-10	2002	The developmental arrest of dSec10 RNAi animals was partially rescued by feeding ecdysone, suggesting dSec10 mediates steroid hormone secretion.	Ecdysone	81-89	Secretory 10	Drosophila melanogaster	102-108
12490155-7	2002	This study revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2, and Z4 first inhibited and then stimulated the process of SG degeneration.	Ecdysone	96-104	broad	Drosophila melanogaster	117-124
12437077-8	2002	In contrast, application of the ecdysone agonist, methoxyfenozide, to plants containing either a constitutive (Ubiquitin1) or anther-specific (maize 5126) VGEcR resulted in the restoration of fertility to ms45 plants grown in either the greenhouse or in the field.	Ecdysone	32-40	strictosidine synthase	Zea mays	205-209
12509227-7	2002	Ecdysone-inducible expression vectors containing wild type XPA cDNA or cDNAs representing the two polymorphisms that we identified in exon 6 were created and independently introduced into the XPA deficient cell line XP12RO-SV.	Ecdysone	0-8	XPA, DNA damage recognition and repair factor	Homo sapiens	59-62
12509227-7	2002	Ecdysone-inducible expression vectors containing wild type XPA cDNA or cDNAs representing the two polymorphisms that we identified in exon 6 were created and independently introduced into the XPA deficient cell line XP12RO-SV.	Ecdysone	0-8	XPA, DNA damage recognition and repair factor	Homo sapiens	192-195
12459199-5	2003	Gel mobility shift assays showed that in vitro translated C. suppressalis ecdysone receptor (CsEcR) and CsUSP proteins bound to the Pal1 or Drosophila melanogaster hsp27 ecdysone response element as a heterodimer.	Ecdysone	74-82	Heat shock protein 27	Drosophila melanogaster	164-169
12045184-0	2002	Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.	Ecdysone	0-8	Death regulator Nedd2-like caspase	Drosophila melanogaster	43-48
12045184-7	2002	These results indicate that BR-C plays a key role in ecdysone-mediated caspase regulation.	Ecdysone	53-61	Death caspase-1	Drosophila melanogaster	71-78
11772948-2	2002	In this paper we describe two novel human cell lines that are capable of expressing high levels of iNOS under the control of analogues of either the insect hormone ecdysone or tetracycline.	Ecdysone	164-172	nitric oxide synthase 2	Homo sapiens	99-103
12036922-4	2002	By measuring the cytotoxicity in a human colon carcinoma cell model with ectopic ecdysone-inducible expression of the cyclin-dependent kinase inhibitor p21(WAF1), specificity toward cycling cells was demonstrated.	Ecdysone	81-89	cyclin dependent kinase inhibitor 1A	Homo sapiens	152-155
12036922-4	2002	By measuring the cytotoxicity in a human colon carcinoma cell model with ectopic ecdysone-inducible expression of the cyclin-dependent kinase inhibitor p21(WAF1), specificity toward cycling cells was demonstrated.	Ecdysone	81-89	cyclin dependent kinase inhibitor 1A	Homo sapiens	156-160
11900466-6	2002	Experiments were conducted to test the role of Broad-Complex (BR-C), an essential component in the ecdysone pathway, in let-7 expression.	Ecdysone	99-107	let-7	Drosophila melanogaster	120-125
11900466-7	2002	We show that ecdysone and BR-C are required for let-7 expression, indicating that the ecdysone pathway regulates the temporal expression of let-7 in Drosophila.	Ecdysone	13-21	let-7	Drosophila melanogaster	48-53
11900466-7	2002	We show that ecdysone and BR-C are required for let-7 expression, indicating that the ecdysone pathway regulates the temporal expression of let-7 in Drosophila.	Ecdysone	13-21	let-7	Drosophila melanogaster	140-145
11969264-8	2002	And we show that the ecdysone-independent upregulation of dnsf1 and dsnap prior to the ecdysone peak leads to a precocious formation of large Golgi stacks.	Ecdysone	21-29	comatose	Drosophila melanogaster	58-63
11969264-8	2002	And we show that the ecdysone-independent upregulation of dnsf1 and dsnap prior to the ecdysone peak leads to a precocious formation of large Golgi stacks.	Ecdysone	21-29	alpha Soluble NSF attachment protein	Drosophila melanogaster	68-73
11969264-8	2002	And we show that the ecdysone-independent upregulation of dnsf1 and dsnap prior to the ecdysone peak leads to a precocious formation of large Golgi stacks.	Ecdysone	87-95	comatose	Drosophila melanogaster	58-63
11969264-8	2002	And we show that the ecdysone-independent upregulation of dnsf1 and dsnap prior to the ecdysone peak leads to a precocious formation of large Golgi stacks.	Ecdysone	87-95	alpha Soluble NSF attachment protein	Drosophila melanogaster	68-73
11853538-0	2002	Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1.	Ecdysone	0-8	mitogen-activated protein kinase 1	Mus musculus	120-157
11853538-0	2002	Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1.	Ecdysone	0-8	dual specificity phosphatase 1	Mus musculus	171-217
11714698-4	2002	Treatment of cells with the synthetic ecdysone analog ponasterone A induced expression of GFP-MKK7(3E) and resulted in sustained activation of endogenous JNK, but neither of the other endogenous MAPKs, ERK or p38.	Ecdysone	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	94-98
11714698-4	2002	Treatment of cells with the synthetic ecdysone analog ponasterone A induced expression of GFP-MKK7(3E) and resulted in sustained activation of endogenous JNK, but neither of the other endogenous MAPKs, ERK or p38.	Ecdysone	38-46	mitogen-activated protein kinase 8	Homo sapiens	154-157
11714698-4	2002	Treatment of cells with the synthetic ecdysone analog ponasterone A induced expression of GFP-MKK7(3E) and resulted in sustained activation of endogenous JNK, but neither of the other endogenous MAPKs, ERK or p38.	Ecdysone	38-46	mitogen-activated protein kinase 14	Homo sapiens	209-212
11879575-14	2002	However, the results of the developmental profile of Pyk expression by Northern blot analysis suggested that the effects of ecdysone on Pyk were repressive, not inductive.	Ecdysone	124-132	Pyruvate kinase	Drosophila melanogaster	53-56
11804781-1	2002	Response to the insect hormone ecdysone is mediated by a nuclear receptor complex containing Ultraspiracle (USP) and the Ecdysone Receptor (EcR).	Ecdysone	31-39	ultraspiracle	Drosophila melanogaster	93-106
11804781-1	2002	Response to the insect hormone ecdysone is mediated by a nuclear receptor complex containing Ultraspiracle (USP) and the Ecdysone Receptor (EcR).	Ecdysone	31-39	ultraspiracle	Drosophila melanogaster	108-111
11804781-1	2002	Response to the insect hormone ecdysone is mediated by a nuclear receptor complex containing Ultraspiracle (USP) and the Ecdysone Receptor (EcR).	Ecdysone	31-39	Ecdysone receptor	Drosophila melanogaster	121-138
11804781-1	2002	Response to the insect hormone ecdysone is mediated by a nuclear receptor complex containing Ultraspiracle (USP) and the Ecdysone Receptor (EcR).	Ecdysone	31-39	Ecdysone receptor	Drosophila melanogaster	140-143
11804781-3	2002	We have shown that USP both represses and activates a gene affecting furrow movement, the ecdysone-responsive Z1 isoform of Broad-Complex, and we report additional usp mutant phenotypes.	Ecdysone	90-98	ultraspiracle	Drosophila melanogaster	19-22
11804781-3	2002	We have shown that USP both represses and activates a gene affecting furrow movement, the ecdysone-responsive Z1 isoform of Broad-Complex, and we report additional usp mutant phenotypes.	Ecdysone	90-98	furrow	Drosophila melanogaster	69-75
11879575-14	2002	However, the results of the developmental profile of Pyk expression by Northern blot analysis suggested that the effects of ecdysone on Pyk were repressive, not inductive.	Ecdysone	124-132	Pyruvate kinase	Drosophila melanogaster	136-139
15455035-10	2002	In contrast, queen and worker pupae that were treated with ecdysone showed a delay in the appearance of vitellogenin.	Ecdysone	59-67	vitellogenin	Apis mellifera	104-116
11606202-8	2001	dMBD-like and/or dMBD-likeDelta is present at the chromocenter on larval polytene chromosomes as well as at discrete bands interspersed along the euchromatic chromosome arms, many of which are coincident with known ecdysone-induced loci.	Ecdysone	215-223	Methyl-CpG binding domain protein-like	Drosophila melanogaster	0-9
11560921-4	2001	We further examined the relationship between MAPK signaling and the effects of alpha-synuclein expression on ecdysone-inducible neuro2a cell lines and found that cells expressing alpha-synuclein had less phosphorylated MAPKs.	Ecdysone	109-117	synuclein, alpha	Mus musculus	79-94
11560921-4	2001	We further examined the relationship between MAPK signaling and the effects of alpha-synuclein expression on ecdysone-inducible neuro2a cell lines and found that cells expressing alpha-synuclein had less phosphorylated MAPKs.	Ecdysone	109-117	synuclein, alpha	Mus musculus	179-194
11641417-2	2001	p21(Waf1) or p27(Kip1) was ectopically expressed with an ecdysone-inducible mammalian expression system in a human colon adenocarcinoma cell line.	Ecdysone	57-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
11641417-2	2001	p21(Waf1) or p27(Kip1) was ectopically expressed with an ecdysone-inducible mammalian expression system in a human colon adenocarcinoma cell line.	Ecdysone	57-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
11641417-2	2001	p21(Waf1) or p27(Kip1) was ectopically expressed with an ecdysone-inducible mammalian expression system in a human colon adenocarcinoma cell line.	Ecdysone	57-65	zinc ribbon domain containing 2	Homo sapiens	13-16
11641417-2	2001	p21(Waf1) or p27(Kip1) was ectopically expressed with an ecdysone-inducible mammalian expression system in a human colon adenocarcinoma cell line.	Ecdysone	57-65	cyclin dependent kinase inhibitor 1B	Homo sapiens	17-21
11335116-2	2001	Studies of the ecdysone response in Drosophila and other insects have shown that 20E exerts its effects initially by the induction of a small number of early genes, including the orphan nuclear receptors HR3, that transduce and amplify the hormone signal.	Ecdysone	15-23	Hormone receptor 3	Drosophila melanogaster	204-207
11576999-9	2001	p53 null human lung cancer H1299 cells transfected with an ecdysone-inducible p53 exhibited equivalent sensitivity to tachpyridine in the presence and absence of p53, demonstrating the lack of requirement for p53 in an isogenic cell system.	Ecdysone	59-67	tumor protein p53	Homo sapiens	0-3
11576999-9	2001	p53 null human lung cancer H1299 cells transfected with an ecdysone-inducible p53 exhibited equivalent sensitivity to tachpyridine in the presence and absence of p53, demonstrating the lack of requirement for p53 in an isogenic cell system.	Ecdysone	59-67	tumor protein p53	Homo sapiens	78-81
11576999-9	2001	p53 null human lung cancer H1299 cells transfected with an ecdysone-inducible p53 exhibited equivalent sensitivity to tachpyridine in the presence and absence of p53, demonstrating the lack of requirement for p53 in an isogenic cell system.	Ecdysone	59-67	tumor protein p53	Homo sapiens	78-81
11576999-9	2001	p53 null human lung cancer H1299 cells transfected with an ecdysone-inducible p53 exhibited equivalent sensitivity to tachpyridine in the presence and absence of p53, demonstrating the lack of requirement for p53 in an isogenic cell system.	Ecdysone	59-67	tumor protein p53	Homo sapiens	78-81
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	cyclin dependent kinase inhibitor 2A	Homo sapiens	229-232
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	cyclin dependent kinase inhibitor 2A	Homo sapiens	233-238
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	cyclin dependent kinase inhibitor 1A	Homo sapiens	241-244
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	cyclin dependent kinase inhibitor 1A	Homo sapiens	245-249
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	interferon alpha inducible protein 27	Homo sapiens	256-259
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	cyclin dependent kinase inhibitor 1B	Homo sapiens	260-264
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	choline kinase alpha	Homo sapiens	273-276
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	RB transcriptional corepressor 1	Homo sapiens	360-362
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	choline kinase alpha	Homo sapiens	372-375
11593424-2	2001	To determine whether this difference can be translated into a therapeutic advantage to protect normal cells from adverse cytotoxicity caused by chemotherapy, we established cell model systems for ecdysone-inducible expression of p16(Ink4a), p21(Waf1), and p27(Kip1) in one CKI-responsive cell line (A431 human vulvar epidermoid carcinoma cells with functional Rb) and one CKI-unresponsive cell line (SiHa human cervical cancer cells with nonfunctional Rb).	Ecdysone	196-204	RB transcriptional corepressor 1	Homo sapiens	452-454
11514618-8	2001	We showed that dGM130 and sec23p expression increases approximately three- and fivefold, respectively, when discs are exposed to ecdysone in vivo and in vitro.	Ecdysone	129-137	Golgi matrix protein 130 kD	Drosophila melanogaster	15-21
11514618-8	2001	We showed that dGM130 and sec23p expression increases approximately three- and fivefold, respectively, when discs are exposed to ecdysone in vivo and in vitro.	Ecdysone	129-137	Secretory 23	Drosophila melanogaster	26-32
11311169-6	2001	Furthermore, the effect of an eve mutation can be rescued both in vivo and in culture by the hormone ecdysone.	Ecdysone	101-109	even skipped	Drosophila melanogaster	30-33
11390382-3	2001	In the present study, we developed a system in which expression of KLF4 is controlled by a promoter that is induced upon treatment of cells containing the receptors for the insect hormone, ecdysone, with ponasterone A, an ecdysone analogue.	Ecdysone	189-197	Kruppel like factor 4	Homo sapiens	67-71
11390382-3	2001	In the present study, we developed a system in which expression of KLF4 is controlled by a promoter that is induced upon treatment of cells containing the receptors for the insect hormone, ecdysone, with ponasterone A, an ecdysone analogue.	Ecdysone	222-230	Kruppel like factor 4	Homo sapiens	67-71
11494129-3	2001	Using the ecdysone-inducible mammalian expression system, a stable inducible GFP-tagged human Pnn gene (PNNGFP) expressing 293 cell line was created (EcR293-PNNGFP).	Ecdysone	10-18	pinin, desmosome associated protein	Homo sapiens	94-97
11559747-4	2001	We have constructed a stable HEK293 cell line that inducibly overexpresses CHMP1 under ecdysone control.	Ecdysone	87-95	charged multivesicular body protein 1A	Homo sapiens	75-80
11422371-0	2001	The ABC transporter Pdr5p mediates the efflux of nonsteroidal ecdysone agonists in Saccharomyces cerevisiae.	Ecdysone	62-70	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	20-25
11399528-3	2001	We recently used the ecdysone inducible gene expression system in hematopoietic cells and found that the two inducer analogs of ecdysone, muristerone A and ponasterone A, altered the signaling pathways induced by IL-3 in the pro-B cell-line, Ba/F3.	Ecdysone	21-29	interleukin 3	Homo sapiens	213-217
11296268-4	2001	A 15- to 20-fold overexpression of 5-MCDG results in the specific demethylation of a stably integrated ecdysone-retinoic acid responsive enhancer-promoter linked to a beta-galactosidase reporter gene.	Ecdysone	103-111	thymine DNA glycosylase	Gallus gallus	35-41
11399528-3	2001	We recently used the ecdysone inducible gene expression system in hematopoietic cells and found that the two inducer analogs of ecdysone, muristerone A and ponasterone A, altered the signaling pathways induced by IL-3 in the pro-B cell-line, Ba/F3.	Ecdysone	128-136	interleukin 3	Homo sapiens	213-217
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	97-105	ultraspiracle	Drosophila melanogaster	51-64
11274407-0	2001	The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response.	Ecdysone	75-83	ultraspiracle	Drosophila melanogaster	17-30
11248701-2	2001	EcR exists in three isoforms EcRA, EcRB1 and EcRB2 that are thought to direct specific physiological responses to ecdysone.	Ecdysone	114-122	Ecdysone receptor	Drosophila melanogaster	0-3
11248701-2	2001	EcR exists in three isoforms EcRA, EcRB1 and EcRB2 that are thought to direct specific physiological responses to ecdysone.	Ecdysone	114-122	Ecdysone receptor	Drosophila melanogaster	29-33
11248701-2	2001	EcR exists in three isoforms EcRA, EcRB1 and EcRB2 that are thought to direct specific physiological responses to ecdysone.	Ecdysone	114-122	Ecdysone receptor	Drosophila melanogaster	35-40
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	97-105	ultraspiracle	Drosophila melanogaster	66-69
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	97-105	Ecdysone receptor	Drosophila melanogaster	116-119
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	207-215	ultraspiracle	Drosophila melanogaster	51-64
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	207-215	ultraspiracle	Drosophila melanogaster	66-69
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	207-215	Ecdysone receptor	Drosophila melanogaster	97-114
11274407-1	2001	The Drosophila homolog of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) to form a functional complex that mediates the effects of the steroid molting hormone ecdysone by activating and repressing expression of ecdysone response genes.	Ecdysone	207-215	Ecdysone receptor	Drosophila melanogaster	116-119
11274407-4	2001	We observed that USP is able to activate as well as repress the Z1 isoform of the ecdysone-responsive broad complex (BrC-Z1).	Ecdysone	82-90	ultraspiracle	Drosophila melanogaster	17-20
11274407-4	2001	We observed that USP is able to activate as well as repress the Z1 isoform of the ecdysone-responsive broad complex (BrC-Z1).	Ecdysone	82-90	broad	Drosophila melanogaster	117-123
11164341-1	2001	The influence of ecdysone on hemomucin isoforms.	Ecdysone	17-25	Hemomucin	Drosophila melanogaster	29-38
11279828-0	2001	The 62E early-late puff of Drosophila contains D-spinophilin, an ecdysone-inducible PDZ-domain protein dynamically expressed during metamorphosis.	Ecdysone	65-73	Spinophilin	Drosophila melanogaster	47-60
11279828-5	2001	Transcription of D-spinophilin is correlated with 62E puff activity during the early stages of metamorphosis and is ecdysone-dependent, making this the first member of this gene family shown to be regulated by a steroid hormone.	Ecdysone	116-124	Spinophilin	Drosophila melanogaster	17-30
11908877-3	2001	To determine the roles of p16 alterations in glioma formation, we have established ecdysone-driven inducible p16 expression in the human glioblastoma cell line CL-4, which were derived from p16-null U87MG cells.	Ecdysone	83-91	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
11908877-3	2001	To determine the roles of p16 alterations in glioma formation, we have established ecdysone-driven inducible p16 expression in the human glioblastoma cell line CL-4, which were derived from p16-null U87MG cells.	Ecdysone	83-91	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
10984473-2	2000	Dronc is the only fly caspase known to be regulated by the hormone ecdysone.	Ecdysone	67-75	Death regulator Nedd2-like caspase	Drosophila melanogaster	0-5
11152710-6	2001	Application of exogenous ecdysone is still effective during the late third instar for the ecd(1)/ecd(1) but not the controls.	Ecdysone	25-33	ecdysoneless	Drosophila melanogaster	90-96
11152710-6	2001	Application of exogenous ecdysone is still effective during the late third instar for the ecd(1)/ecd(1) but not the controls.	Ecdysone	25-33	ecdysoneless	Drosophila melanogaster	97-103
11118881-4	2001	Our results show that an ecdysone-responsive element located within the ng-1 coding region is necessary for high-level gene expression, whereas the gene"s spatial and temporal expression profile is fully controlled by a distinct upstream regulatory region.	Ecdysone	25-33	new glue 1	Drosophila melanogaster	72-76
10931948-0	2000	The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation.	Ecdysone	44-52	Early gene at 23	Drosophila melanogaster	4-7
10976044-0	2000	The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels.	Ecdysone	134-142	disembodied	Drosophila melanogaster	15-26
11082204-10	2000	These results suggest that ecdysone hydroxylation in the early stage of embryogenesis is dependent on the presence of both P450 reductase and ecdysone 20-hydroxylase P450, but its gradual reduction in the later stage may be due to the decrease in the level of ecdysone 20-hydroxylase P450.	Ecdysone	27-35	ecdysone 20-hydroxylase	Bombyx mori	142-165
11082204-10	2000	These results suggest that ecdysone hydroxylation in the early stage of embryogenesis is dependent on the presence of both P450 reductase and ecdysone 20-hydroxylase P450, but its gradual reduction in the later stage may be due to the decrease in the level of ecdysone 20-hydroxylase P450.	Ecdysone	27-35	ecdysone 20-hydroxylase	Bombyx mori	260-283
10989290-4	2000	Taken together, these results demonstrate the selectivity of EcR for a series of natural and synthetic ecdysone agonists and suggest that as yet untested compounds may be responsible for activating DHR38, DHR78 and DHR96.	Ecdysone	103-111	Ecdysone receptor	Drosophila melanogaster	61-64
11027214-10	2000	Blocking p75-mediated activation of NF-kappaB by ecdysone-inducible expression of a nondegradable mutant of IkappaBalpha significantly enhanced apoptosis.	Ecdysone	49-57	nerve growth factor receptor	Rattus norvegicus	9-12
11027214-10	2000	Blocking p75-mediated activation of NF-kappaB by ecdysone-inducible expression of a nondegradable mutant of IkappaBalpha significantly enhanced apoptosis.	Ecdysone	49-57	NFKB inhibitor alpha	Rattus norvegicus	108-120
11093245-0	2000	Catalase expression in Drosophila melanogaster is responsive to ecdysone and exhibits both transcriptional and post-transcriptional regulation.	Ecdysone	64-72	Catalase	Drosophila melanogaster	0-8
10978288-5	2000	We show that E63-1 is expressed in many embryonic and larval tissues, but the third-instar larval salivary gland is the only tissue where increases in protein levels correlate with increases in ecdysone titer.	Ecdysone	194-202	Ecdysone-induced protein 63F 1	Drosophila melanogaster	13-18
10982412-6	2000	In EcR-CHO cells, the expression level of podocalyxin induced by increasing levels of ecdysone analogue correlated closely with the antiadhesion effect.	Ecdysone	86-94	podocalyxin like	Canis lupus familiaris	42-53
10931948-0	2000	The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation.	Ecdysone	118-126	Early gene at 23	Drosophila melanogaster	4-7
10931948-6	2000	Using heat shock-inducible transgenes, we found that E23 overexpression not only produces phenotypic abnormalities and lethality, but also interferes with ecdysone-mediated gene activation, demonstrating that E23 is capable of modulating the ecdysone response.	Ecdysone	155-163	Early gene at 23	Drosophila melanogaster	53-56
10931948-6	2000	Using heat shock-inducible transgenes, we found that E23 overexpression not only produces phenotypic abnormalities and lethality, but also interferes with ecdysone-mediated gene activation, demonstrating that E23 is capable of modulating the ecdysone response.	Ecdysone	155-163	Early gene at 23	Drosophila melanogaster	209-212
10931948-6	2000	Using heat shock-inducible transgenes, we found that E23 overexpression not only produces phenotypic abnormalities and lethality, but also interferes with ecdysone-mediated gene activation, demonstrating that E23 is capable of modulating the ecdysone response.	Ecdysone	242-250	Early gene at 23	Drosophila melanogaster	53-56
10931948-6	2000	Using heat shock-inducible transgenes, we found that E23 overexpression not only produces phenotypic abnormalities and lethality, but also interferes with ecdysone-mediated gene activation, demonstrating that E23 is capable of modulating the ecdysone response.	Ecdysone	242-250	Early gene at 23	Drosophila melanogaster	209-212
10753890-3	2000	In Chinese hamster ovary cells transfected with retinoid X receptor alpha (RXRalpha)/FXR, only chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) were able to stimulate a heterologous promoter/reporter containing an ecdysone response element.	Ecdysone	221-229	retinoic acid receptor RXR-alpha	Cricetulus griseus	75-83
10898964-2	2000	Here, we show that betaFTZ-F1, the nuclear receptor implicated as a competence factor for stage-specific responses to ecdysone during Drosophila metamorphosis, serves a similar function during mosquito vitellogenesis.	Ecdysone	118-126	ftz transcription factor 1	Drosophila melanogaster	19-29
10772791-0	2000	Kruppel-homolog, a stage-specific modulator of the prepupal ecdysone response, is essential for Drosophila metamorphosis.	Ecdysone	60-68	Kruppel homolog 2	Drosophila melanogaster	0-15
10713724-8	2000	Similar l(2)gl-dependence is noticed in the timing of expression of the cell death genes reaper, head involution defective and grim, supporting the idea that p127 plays a critical role in the implementation of ecdysone-triggered apoptosis.	Ecdysone	210-218	grim	Drosophila melanogaster	127-131
10713453-7	2000	Hrb57A/Q18 specifically coprecipitates four other proteins: Hrb87F/P11 a Drosophila hnRNP A1 homologue, the hnRNA-binding protein S5, the RNA recognition motif-containing protein NonA and the RNA-binding zinc finger-containing protein on ecdysone puffs PEP/X4.	Ecdysone	238-246	Heterogeneous nuclear ribonucleoprotein K	Drosophila melanogaster	0-6
10713453-7	2000	Hrb57A/Q18 specifically coprecipitates four other proteins: Hrb87F/P11 a Drosophila hnRNP A1 homologue, the hnRNA-binding protein S5, the RNA recognition motif-containing protein NonA and the RNA-binding zinc finger-containing protein on ecdysone puffs PEP/X4.	Ecdysone	238-246	Heterogeneous nuclear ribonucleoprotein K	Drosophila melanogaster	7-10
10715536-5	2000	We have previously demonstrated the conservation of a primary ecdysone-triggered regulatory hierarchy, implicated in development of immature stages of Drosophila, represented by the ecdysone receptor/Ultraspiracle complex and an early gene E75 during the reproductive ecdysone response (Wang, S.-F., Miura, K., Miksicek, R.J., Segraves, W.A., Raikhel, A.S., 1998.	Ecdysone	62-70	Ecdysone-induced protein 75B	Drosophila melanogaster	240-243
10882130-2	2000	This response is preceded by an ecdysone-triggered switch in gene expression in which the diap2 death inhibitor is repressed and the reaper (rpr) and head involution defective (hid) death activators are induced.	Ecdysone	32-40	Death-associated inhibitor of apoptosis 2	Drosophila melanogaster	90-95
10713724-8	2000	Similar l(2)gl-dependence is noticed in the timing of expression of the cell death genes reaper, head involution defective and grim, supporting the idea that p127 plays a critical role in the implementation of ecdysone-triggered apoptosis.	Ecdysone	210-218	lethal (2) giant larvae	Drosophila melanogaster	158-162
10602327-2	1999	In this study we have examined the use of the ecdysone-inducible mammalian expression system (Invitrogen) for the regulation of expression of the predominant L-glutamate transporter EAAT2 (Excitatory Amino Acid Transporter) in HEK 293 cells.	Ecdysone	46-54	solute carrier family 1 member 2	Homo sapiens	182-187
10585281-2	1999	Three other proteins present in the complex have been identified: X4/PEP (protein on ecdysone puffs), a 100-kDa zinc finger RNA-binding protein; the 70-kDa S5 protein, an as yet uncharacterized RNA-binding protein; and P11/Hrb87F, a 38-kDa RRM protein homologous to hnRNP protein A1 from mammals.	Ecdysone	85-93	Protein on ecdysone puffs	Drosophila melanogaster	66-72
10602327-7	1999	Exposure of HEK/EAAT2 cells to the ecdysone analogue Ponasterone A (10 microM for 24 h) resulted in a > or = 10 fold increase in the Na+-dependent activity.	Ecdysone	35-43	solute carrier family 1 member 2	Homo sapiens	16-21
10602327-15	1999	This study demonstrates that the expression of EAAT2 can be regulated in a mammalian cell line using the ecdysone-inducible mammalian expression system.	Ecdysone	105-113	solute carrier family 1 member 2	Homo sapiens	47-52
9675555-1	1998	The activity of Drosophila cytosolic malate dehydrogenase (MDH; EC 1.1.1.40), a key enzyme in the biosynthesis of lipids, was found to be regulated by both the sesquiterpenoid juvenile hormone (JH), and the steroid hormone ecdysone.	Ecdysone	223-231	Malate dehydrogenase 1	Drosophila melanogaster	27-57
10548497-1	1999	The cDNA encoding the predominant rat brain high-affinity l-glutamate transporter GLT-1 was isolated and subcloned into the pIND expression vector for the establishment of steroid hormone inducible expression in vitro using the ecdysone-inducible mammalian expression system.	Ecdysone	228-236	solute carrier family 1 member 2	Rattus norvegicus	82-87
10498692-5	1999	The stage 10 follicle cell expression of E75 in wild-type, K10 and EGF receptor (Egfr) mutant egg chambers reveals regulation of E75 by both the Egfr and ecdysone signaling pathways.	Ecdysone	154-162	Ecdysone-induced protein 75B	Drosophila melanogaster	41-44
10498692-5	1999	The stage 10 follicle cell expression of E75 in wild-type, K10 and EGF receptor (Egfr) mutant egg chambers reveals regulation of E75 by both the Egfr and ecdysone signaling pathways.	Ecdysone	154-162	Epidermal growth factor receptor	Drosophila melanogaster	67-79
10498692-5	1999	The stage 10 follicle cell expression of E75 in wild-type, K10 and EGF receptor (Egfr) mutant egg chambers reveals regulation of E75 by both the Egfr and ecdysone signaling pathways.	Ecdysone	154-162	Epidermal growth factor receptor	Drosophila melanogaster	81-85
10498692-5	1999	The stage 10 follicle cell expression of E75 in wild-type, K10 and EGF receptor (Egfr) mutant egg chambers reveals regulation of E75 by both the Egfr and ecdysone signaling pathways.	Ecdysone	154-162	Ecdysone-induced protein 75B	Drosophila melanogaster	129-132
10498692-9	1999	Together these data suggest that the temporal expression profile of E75, E74 and BR-C may be a functional reflection of ecdysone levels and that ecdysone provides temporal signals regulating the progression of oogenesis and proper specification of dorsal follicle cell fates.	Ecdysone	120-128	Ecdysone-induced protein 75B	Drosophila melanogaster	68-71
10498692-9	1999	Together these data suggest that the temporal expression profile of E75, E74 and BR-C may be a functional reflection of ecdysone levels and that ecdysone provides temporal signals regulating the progression of oogenesis and proper specification of dorsal follicle cell fates.	Ecdysone	120-128	brc	Drosophila melanogaster	81-85
10504412-2	1999	In order to understand the role that 20-hydroxyecdysone plays during development of the Mediterranean fruit fly Ceratitis capitata (medfly), a major agricultural pest, we have cloned a Ceratitis ecdysone receptor (CcEcR) and studied its expression and its binding properties to an ecdysone response element.	Ecdysone	47-55	Ecdysone receptor	Drosophila melanogaster	195-212
10504412-2	1999	In order to understand the role that 20-hydroxyecdysone plays during development of the Mediterranean fruit fly Ceratitis capitata (medfly), a major agricultural pest, we have cloned a Ceratitis ecdysone receptor (CcEcR) and studied its expression and its binding properties to an ecdysone response element.	Ecdysone	47-55	ras guanine nucleotide exchange factor B	Ceratitis capitata	214-219
10504412-9	1999	Electrophoretic mobility shift assays indicated that CcEcR binds specifically to the Drosophila hsp27 ecdysone response element as a heterodimer with Drosophila USP, the product of the ultraspiracle gene.	Ecdysone	102-110	ras guanine nucleotide exchange factor B	Ceratitis capitata	53-58
10504412-9	1999	Electrophoretic mobility shift assays indicated that CcEcR binds specifically to the Drosophila hsp27 ecdysone response element as a heterodimer with Drosophila USP, the product of the ultraspiracle gene.	Ecdysone	102-110	Heat shock protein 27	Drosophila melanogaster	96-101
10454568-6	1999	(i) Complete Grb10 expression from cDNA with an ecdysone-regulated transient expression system stimulated PDGF-BB-, IGF-I, and insulin- but not epidermal growth factor (EGF)-induced DNA synthesis in an ecdysone dose-responsive fashion.	Ecdysone	48-56	Insulin-like receptor	Drosophila melanogaster	127-134
10419696-10	1999	These studies demonstrate that DHR3 is an essential regulator of the betaFTZ-F1 midprepupal competence factor, providing a functional link between the late larval and prepupal responses to ecdysone.	Ecdysone	189-197	Hormone receptor 3	Drosophila melanogaster	31-35
10419696-10	1999	These studies demonstrate that DHR3 is an essential regulator of the betaFTZ-F1 midprepupal competence factor, providing a functional link between the late larval and prepupal responses to ecdysone.	Ecdysone	189-197	ftz transcription factor 1	Drosophila melanogaster	69-79
10419696-11	1999	Induction of DHR3 in early prepupae ensures that responses to the prepupal ecdysone pulse will be distinct from responses to the late larval pulse and thus that the animal progresses in an appropriate manner through the early stages of metamorphosis.	Ecdysone	75-83	Hormone receptor 3	Drosophila melanogaster	13-17
10409761-0	1999	Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster.	Ecdysone	78-86	Ecdysone receptor	Drosophila melanogaster	25-28
10409761-0	1999	Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster.	Ecdysone	78-86	ultraspiracle	Drosophila melanogaster	29-32
10409761-0	1999	Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster.	Ecdysone	78-86	serpent	Drosophila melanogaster	58-64
10318923-10	1999	Results from our pilot screens include (i) the identification of a homologue of the immunophilin FKBP-12 with dorsal anterior expression in egg chambers, (ii) the discovery that the ecdysone-inducible nuclear hormone receptor gene E78 is regulated by grk during oogenesis and is required for proper dorsal appendage formation, and (iii) the identification of a Drosophila homologue of the human SET-binding factor gene SBF1 with elevated transcription in grk mutant egg chambers.	Ecdysone	182-190	Ecdysone-induced protein 78C	Drosophila melanogaster	231-234
10318923-10	1999	Results from our pilot screens include (i) the identification of a homologue of the immunophilin FKBP-12 with dorsal anterior expression in egg chambers, (ii) the discovery that the ecdysone-inducible nuclear hormone receptor gene E78 is regulated by grk during oogenesis and is required for proper dorsal appendage formation, and (iii) the identification of a Drosophila homologue of the human SET-binding factor gene SBF1 with elevated transcription in grk mutant egg chambers.	Ecdysone	182-190	gurken	Drosophila melanogaster	251-254
10318923-10	1999	Results from our pilot screens include (i) the identification of a homologue of the immunophilin FKBP-12 with dorsal anterior expression in egg chambers, (ii) the discovery that the ecdysone-inducible nuclear hormone receptor gene E78 is regulated by grk during oogenesis and is required for proper dorsal appendage formation, and (iii) the identification of a Drosophila homologue of the human SET-binding factor gene SBF1 with elevated transcription in grk mutant egg chambers.	Ecdysone	182-190	SET binding factor 1	Homo sapiens	419-423
10318923-10	1999	Results from our pilot screens include (i) the identification of a homologue of the immunophilin FKBP-12 with dorsal anterior expression in egg chambers, (ii) the discovery that the ecdysone-inducible nuclear hormone receptor gene E78 is regulated by grk during oogenesis and is required for proper dorsal appendage formation, and (iii) the identification of a Drosophila homologue of the human SET-binding factor gene SBF1 with elevated transcription in grk mutant egg chambers.	Ecdysone	182-190	gurken	Drosophila melanogaster	455-458
9874786-6	1999	Immunoprecipitation analysis showed that both CED-4 and CED-4 (K165R) bind directly to Drosophila caspase drICE, and the overexpression of CED-4 (K165R) inhibits CED-4-, ecdysone-, or cycloheximide-dependent caspase activation in S2 cells.	Ecdysone	170-178	Cell death protein 4	Caenorhabditis elegans	46-51
9874786-6	1999	Immunoprecipitation analysis showed that both CED-4 and CED-4 (K165R) bind directly to Drosophila caspase drICE, and the overexpression of CED-4 (K165R) inhibits CED-4-, ecdysone-, or cycloheximide-dependent caspase activation in S2 cells.	Ecdysone	170-178	Cell death protein 4	Caenorhabditis elegans	56-61
9874786-6	1999	Immunoprecipitation analysis showed that both CED-4 and CED-4 (K165R) bind directly to Drosophila caspase drICE, and the overexpression of CED-4 (K165R) inhibits CED-4-, ecdysone-, or cycloheximide-dependent caspase activation in S2 cells.	Ecdysone	170-178	Death caspase-1	Drosophila melanogaster	98-105
9874786-6	1999	Immunoprecipitation analysis showed that both CED-4 and CED-4 (K165R) bind directly to Drosophila caspase drICE, and the overexpression of CED-4 (K165R) inhibits CED-4-, ecdysone-, or cycloheximide-dependent caspase activation in S2 cells.	Ecdysone	170-178	Cell death protein 4	Caenorhabditis elegans	56-61
9874786-6	1999	Immunoprecipitation analysis showed that both CED-4 and CED-4 (K165R) bind directly to Drosophila caspase drICE, and the overexpression of CED-4 (K165R) inhibits CED-4-, ecdysone-, or cycloheximide-dependent caspase activation in S2 cells.	Ecdysone	170-178	Cell death protein 4	Caenorhabditis elegans	56-61
9806919-4	1998	Rather, usp is required in late third instar larvae for appropriate developmental and transcriptional responses to the ecdysone pulse that triggers puparium formation.	Ecdysone	119-127	ultraspiracle	Drosophila melanogaster	8-11
9788435-1	1998	The p53-null human lung cancer cell line H1299 was used in order to generate clones with ecdysone-inducible p53 as well as ecdysone-inducible p21waf1.	Ecdysone	89-97	tumor protein p53	Homo sapiens	4-7
9788435-1	1998	The p53-null human lung cancer cell line H1299 was used in order to generate clones with ecdysone-inducible p53 as well as ecdysone-inducible p21waf1.	Ecdysone	89-97	tumor protein p53	Homo sapiens	108-111
9788435-1	1998	The p53-null human lung cancer cell line H1299 was used in order to generate clones with ecdysone-inducible p53 as well as ecdysone-inducible p21waf1.	Ecdysone	123-131	tumor protein p53	Homo sapiens	4-7
9722628-1	1998	The Drosophila protein PEP (protein on ecdysone puffs), a component hnRNP complexes, was previously immunocytologically localized on Drosophila giant chromosomes to puffs induced by ecdysone and to some heat shock-induced puffs (e.g. at the hsp70 locus at 87A7).	Ecdysone	39-47	Protein on ecdysone puffs	Drosophila melanogaster	23-26
9722628-1	1998	The Drosophila protein PEP (protein on ecdysone puffs), a component hnRNP complexes, was previously immunocytologically localized on Drosophila giant chromosomes to puffs induced by ecdysone and to some heat shock-induced puffs (e.g. at the hsp70 locus at 87A7).	Ecdysone	39-47	Heat-shock-protein-70Ab	Drosophila melanogaster	241-246
10559252-5	1999	We generated SW480.7 cells conditionally expressing Smad4 via an ecdysone-inducible system.	Ecdysone	65-73	SMAD family member 4	Homo sapiens	52-57
9649534-2	1998	In addition to binding to specific response elements as a monomer, DHR38 interacts with the USP component of the ecdysone receptor complex in vitro, in yeast and in a cell line, suggesting that DHR38 might modulate ecdysone-triggered signals in the fly.	Ecdysone	113-121	Hormone receptor-like in 38	Drosophila melanogaster	67-72
9649534-2	1998	In addition to binding to specific response elements as a monomer, DHR38 interacts with the USP component of the ecdysone receptor complex in vitro, in yeast and in a cell line, suggesting that DHR38 might modulate ecdysone-triggered signals in the fly.	Ecdysone	113-121	Hormone receptor-like in 38	Drosophila melanogaster	194-199
9521911-8	1998	The EcR ecdysone receptor, and the BR-C, E74 and E75 early regulatory genes, are submaximally induced in crol mutants in response to the prepupal ecdysone pulse.	Ecdysone	8-16	crooked legs	Drosophila melanogaster	105-109
9494095-5	1998	Kinetic analysis showed that EGT has broadly similar specificities for UDP-galactose and UDP-glucose (kcat/Km=1790.8 and 902.1 respectively) when ecdysone is used as the other substrate.	Ecdysone	146-154	ecdysteroid UDP-glucosyl transferase	Autographa californica nucleopolyhedrovirus	29-32
9675555-1	1998	The activity of Drosophila cytosolic malate dehydrogenase (MDH; EC 1.1.1.40), a key enzyme in the biosynthesis of lipids, was found to be regulated by both the sesquiterpenoid juvenile hormone (JH), and the steroid hormone ecdysone.	Ecdysone	223-231	Malate dehydrogenase 1	Drosophila melanogaster	59-62
9675555-2	1998	The responsiveness of MDH to JH largely depended on the developmental stage or endogenous titre of ecdysone.	Ecdysone	99-107	Malate dehydrogenase 1	Drosophila melanogaster	22-25
9675555-3	1998	During the early through middle period of the last larval instar, when ecdysone levels are low, MDH responded to JH rapidly by increasing activity, while little or no response was measured in mature larvae (postfeeding stage) and fresh pupae when the endogenous pulse of ecdysone is high.	Ecdysone	71-79	Malate dehydrogenase 1	Drosophila melanogaster	96-99
9675555-3	1998	During the early through middle period of the last larval instar, when ecdysone levels are low, MDH responded to JH rapidly by increasing activity, while little or no response was measured in mature larvae (postfeeding stage) and fresh pupae when the endogenous pulse of ecdysone is high.	Ecdysone	271-279	Malate dehydrogenase 1	Drosophila melanogaster	96-99
9675555-4	1998	Activity of MDH in ecd1 and su(f)ts67g, two ecdysone-deficient mutants of Drosophila, was increased when compared to wild type controls, and was also sensitive to administration of JH.	Ecdysone	44-52	Malate dehydrogenase 1	Drosophila melanogaster	12-15
9131782-0	1997	Ecdysone-modulated response of Drosophila cytosolic malate dehydrogenase to juvenile hormone.	Ecdysone	0-8	Malate dehydrogenase 1	Drosophila melanogaster	42-72
9413987-3	1997	In the larval salivary gland, loss of EcR-B1 results in loss of activation of ecdysone-induced genes.	Ecdysone	78-86	Ecdysone receptor	Drosophila melanogaster	38-44
9273145-0	1997	Disruption of the IP3 receptor gene of Drosophila affects larval metamorphosis and ecdysone release.	Ecdysone	83-91	Inositol 1,4,5,-trisphosphate receptor	Drosophila melanogaster	18-30
9273145-9	1997	In order to assess ecdysone levels at all larval stages, we examined transcripts of an ecdysone-inducible gene, E74; these transcripts were downregulated in larvae expressing each of the itpr alleles.	Ecdysone	19-27	Ecdysone-induced protein 74EF	Drosophila melanogaster	112-115
9273145-9	1997	In order to assess ecdysone levels at all larval stages, we examined transcripts of an ecdysone-inducible gene, E74; these transcripts were downregulated in larvae expressing each of the itpr alleles.	Ecdysone	87-95	Ecdysone-induced protein 74EF	Drosophila melanogaster	112-115
9273145-10	1997	CONCLUSIONS: Our data show that disruption of the Drosophila IP3 receptor gene leads to lowered levels of ecdysone.	Ecdysone	106-114	Inositol 1,4,5,-trisphosphate receptor	Drosophila melanogaster	61-73
9408090-1	1997	Transcriptional activation of the Drosophila ecdysone receptor (EcR) was studied in yeast cells, which carry a reporter plasmid containing the ecdysone response element in the absence or presence of its heterodimeric partners, ultraspiracle protein (USP) or human retinoid X receptor (RXRalpha).	Ecdysone	45-53	Ecdysone receptor	Drosophila melanogaster	64-67
9165123-4	1997	DHR3 protein is bound to many ecdysone-induced puffs in the polytene chromosomes, including the early puffs that encode the BR-C and E74 regulatory genes, as well as the E75, E78 and betaFTZ-F1 orphan receptor loci.	Ecdysone	30-38	Hormone receptor 3	Drosophila melanogaster	0-4
9165123-8	1997	DHR3 thus appears to function as a switch that defines the larval-prepupal transition by arresting the early regulatory response to ecdysone at puparium formation and facilitating the induction of the betaFTZ-F1 competence factor in mid-prepupae.	Ecdysone	132-140	Hormone receptor 3	Drosophila melanogaster	0-4
9082981-1	1997	The functions of the ecdysone-induced DHR3 and E75B orphan nuclear receptors in the early stages of Drosophila metamorphosis were investigated.	Ecdysone	21-29	Hormone receptor 3	Drosophila melanogaster	38-42
9082981-1	1997	The functions of the ecdysone-induced DHR3 and E75B orphan nuclear receptors in the early stages of Drosophila metamorphosis were investigated.	Ecdysone	21-29	Ecdysone-induced protein 75B	Drosophila melanogaster	47-51
9128741-0	1997	Sequence, structure and evolution of the ecdysone-inducible Lsp-2 gene of Drosophila melanogaster.	Ecdysone	41-49	Larval serum protein 2	Drosophila melanogaster	60-65
9125169-3	1997	Arrest of ecdysone synthesis led to a decrease in CYP6A2 mRNA level, as well as in P450B expression and activities.	Ecdysone	10-18	Cytochrome P450-6a2	Drosophila melanogaster	50-56
9125169-3	1997	Arrest of ecdysone synthesis led to a decrease in CYP6A2 mRNA level, as well as in P450B expression and activities.	Ecdysone	10-18	Cytochrome P450-6a2	Drosophila melanogaster	83-88
9342356-0	1997	DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis.	Ecdysone	9-17	Hormone receptor 3	Drosophila melanogaster	0-4
9342356-2	1997	The DHR3 gene, located within the 46F early-late ecdysone-inducible chromosome puff, encodes an orphan nuclear receptor that recently has been shown to exert both positive and negative regulatory effects in the ecdysone-induced genetic hierarchies at metamorphosis.	Ecdysone	49-57	Hormone receptor 3	Drosophila melanogaster	4-8
9342356-2	1997	The DHR3 gene, located within the 46F early-late ecdysone-inducible chromosome puff, encodes an orphan nuclear receptor that recently has been shown to exert both positive and negative regulatory effects in the ecdysone-induced genetic hierarchies at metamorphosis.	Ecdysone	211-219	Hormone receptor 3	Drosophila melanogaster	4-8
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysone	63-71	fork head	Drosophila melanogaster	11-20
8887683-5	1996	Our analysis shows that the ecdysone response element is necessary but not sufficient for full developmental expression of hsp23 in the late third instar and that there is, indeed, another regulatory element, in the vicinity of DHS-1400.	Ecdysone	28-36	Heat shock protein 23	Drosophila melanogaster	123-128
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysone	63-71	fork head	Drosophila melanogaster	21-26
8890156-2	1996	Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone.	Ecdysone	63-71	Salivary gland secretion 4	Drosophila melanogaster	145-150
8524239-4	1995	Transfection assays in CV-1 cells demonstrate that Seven-up can inhibit ecdysone-dependent transactivation by the ecdysone receptor complex, a heterodimeric complex of Usp and ecdysone receptor.	Ecdysone	72-80	seven up	Drosophila melanogaster	51-59
8660653-8	1996	Developmental RNA get analysis shows that peaks of catalase mRNA accumulation correspond roughly with major peaks of ecdysone titer during third instar and pupal stages.	Ecdysone	117-125	Catalase	Drosophila melanogaster	51-59
8606006-9	1996	It is not clear whether those sequences which respond to 20E are genuine ecdysone response elements (i.e., binding sites for the ecdysone receptor) or if the effect is indirect.	Ecdysone	73-81	Ecdysone receptor	Drosophila melanogaster	129-146
8544820-0	1995	Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene.	Ecdysone	69-77	Larval serum protein 2	Drosophila melanogaster	111-116
8524239-4	1995	Transfection assays in CV-1 cells demonstrate that Seven-up can inhibit ecdysone-dependent transactivation by the ecdysone receptor complex, a heterodimeric complex of Usp and ecdysone receptor.	Ecdysone	72-80	Ecdysone receptor	Drosophila melanogaster	114-131
8524239-4	1995	Transfection assays in CV-1 cells demonstrate that Seven-up can inhibit ecdysone-dependent transactivation by the ecdysone receptor complex, a heterodimeric complex of Usp and ecdysone receptor.	Ecdysone	72-80	ultraspiracle	Drosophila melanogaster	168-171
8524239-4	1995	Transfection assays in CV-1 cells demonstrate that Seven-up can inhibit ecdysone-dependent transactivation by the ecdysone receptor complex, a heterodimeric complex of Usp and ecdysone receptor.	Ecdysone	72-80	Ecdysone receptor	Drosophila melanogaster	176-193
8524239-6	1995	Ectopic expression of Svp in vivo induces lethality during early metamorphosis, the time of maximal ecdysone responsiveness.	Ecdysone	100-108	seven up	Drosophila melanogaster	22-25
8582299-9	1995	The data reinforce the idea that BR-C, which clearly mediates a salivary gland-specific response to ecdysone, may play a widespread role in the hormone"s activation of gene cascades in other target tissues.	Ecdysone	100-108	brc	Drosophila melanogaster	33-37
7671827-7	1995	First, the 63F puff contains a pair of ecdysone-inducible genes that are transcribed in the larval salivary glands: E63-1 and E63-2.	Ecdysone	39-47	Ecdysone-induced protein 63F 1	Drosophila melanogaster	116-131
8155577-0	1993	In vivo functional characterization of an ecdysone response enhancer in the proximal upstream region of the Fbp1 gene of D. melanogaster.	Ecdysone	42-50	Fat body protein 1	Drosophila melanogaster	108-112
7783195-1	1995	Within the 2.2 kb region between hsp23 and gene 1 of the small heat shock gene locus 67B1 of Drosophila melanogaster, an approximately 1 kb perturbation of the chromatin architecture has previously been observed to occur in response to the steroid hormone ecdysone.	Ecdysone	256-264	Heat shock protein 23	Drosophila melanogaster	33-38
7783195-2	1995	Transient expression assays in hormonally-responsive Drosophila tissue culture cells utilizing hsp70-lacZ chimeric reporter constructs revealed the presence of ecdysone-dependent regulatory sequences in this hsp23-gene 1 intergenic region.	Ecdysone	160-168	Heat-shock-protein-70Ab	Drosophila melanogaster	95-100
7783195-2	1995	Transient expression assays in hormonally-responsive Drosophila tissue culture cells utilizing hsp70-lacZ chimeric reporter constructs revealed the presence of ecdysone-dependent regulatory sequences in this hsp23-gene 1 intergenic region.	Ecdysone	160-168	Heat shock protein 23	Drosophila melanogaster	208-213
7783195-8	1995	The data obtained strongly suggest that the cis-acting elements delimited within the hsp23-gene 1 intergenic region respond to ecdysone in a secondary manner, presumably by requiring interaction with the product(s) of primary ecdysone-responsive genes.	Ecdysone	127-135	Heat shock protein 23	Drosophila melanogaster	85-90
7783195-8	1995	The data obtained strongly suggest that the cis-acting elements delimited within the hsp23-gene 1 intergenic region respond to ecdysone in a secondary manner, presumably by requiring interaction with the product(s) of primary ecdysone-responsive genes.	Ecdysone	226-234	Heat shock protein 23	Drosophila melanogaster	85-90
7954827-6	1994	These findings indicate that beta FTZ-F1 plays a central role in the prepupal genetic response to ecdysone and provide a molecular mechanism for stage-specific responses to steroid hormones.	Ecdysone	98-106	ftz transcription factor 1	Drosophila melanogaster	29-40
7951266-1	1994	The Drosophila melanogaster E74A gene is expressed in response to the steroid hormone ecdysone.	Ecdysone	86-94	Ecdysone-induced protein 74EF	Drosophila melanogaster	28-32
8253380-3	1993	Major ecdysone-induced puffs, for example, stain exclusively for Pol IIO, indicating that hyperphosphorylated Pol II is the transcriptionally active form of the enzyme on these genes.	Ecdysone	6-14	RNA polymerase II 215kD subunit	Drosophila melanogaster	65-72
8253380-3	1993	Major ecdysone-induced puffs, for example, stain exclusively for Pol IIO, indicating that hyperphosphorylated Pol II is the transcriptionally active form of the enzyme on these genes.	Ecdysone	6-14	RNA polymerase II 215kD subunit	Drosophila melanogaster	65-71
7760852-9	1995	Both RIP14 and 15 bind as heterodimers with RXR to the RA response element (RARE) from the promoter of the RAR beta 2 isoform (the beta RARE), and RIP14 and RXR heterodimers also bind the ecdysone response element from the Drosophila heat shock protein 27 promoter.	Ecdysone	188-196	Heat shock protein 27	Drosophila melanogaster	234-255
8007953-0	1994	The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor.	Ecdysone	4-12	Fat body protein 1	Drosophila melanogaster	38-42
8007953-0	1994	The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor.	Ecdysone	4-12	Ecdysone receptor	Drosophila melanogaster	102-105
8007953-0	1994	The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor.	Ecdysone	4-12	ultraspiracle	Drosophila melanogaster	106-109
7981038-2	1994	PTTH stimulates the prothoracic glands to synthesize and release ecdysone, and is therefore a key hormone for the regulation of insect moulting and metamorphosis.	Ecdysone	65-73	prothoracicotropic hormone	Bombyx mori	0-4
8151299-3	1994	The egt gene from the related baculovirus Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) disrupts the hormonal balance of the host larva by galactosylating ecdysone, which prevents moulting.	Ecdysone	186-194	ecdysteroid UDP-glucosyl transferase	Autographa californica nucleopolyhedrovirus	4-7
8375576-0	1993	Intronic and 5" flanking sequences of the Drosophila beta 3 tubulin gene are essential to confer ecdysone responsiveness.	Ecdysone	97-105	beta-Tubulin at 60D	Drosophila melanogaster	53-67
8402914-2	1993	This puff contains a single ecdysone-inducible gene consisting of two nested transcription units, E78A and E78B.	Ecdysone	28-36	Ecdysone-induced protein 78C	Drosophila melanogaster	107-111
8402914-5	1993	E78B is directly inducible by ecdysone in late third instar larvae and depends on ecdysone-induced protein synthesis for its maximal level of expression.	Ecdysone	30-38	Ecdysone-induced protein 78C	Drosophila melanogaster	0-4
8402914-5	1993	E78B is directly inducible by ecdysone in late third instar larvae and depends on ecdysone-induced protein synthesis for its maximal level of expression.	Ecdysone	82-90	Ecdysone-induced protein 78C	Drosophila melanogaster	0-4
8355684-1	1993	The protein on ecdysone puffs (PEP) is associated preferentially with active ecdysone-inducible puffs on Drosophila polytene chromosomes and contains sequence motifs characteristic of transcription factors and RNA-binding proteins (S. A. Amero, S. C. R. Elgin, and A. L. Beyer, Genes Dev.	Ecdysone	15-23	Protein on ecdysone puffs	Drosophila melanogaster	31-34
8355684-1	1993	The protein on ecdysone puffs (PEP) is associated preferentially with active ecdysone-inducible puffs on Drosophila polytene chromosomes and contains sequence motifs characteristic of transcription factors and RNA-binding proteins (S. A. Amero, S. C. R. Elgin, and A. L. Beyer, Genes Dev.	Ecdysone	77-85	Protein on ecdysone puffs	Drosophila melanogaster	31-34
8324824-3	1993	We have used isoform-specific monoclonal antibodies to show that at the onset of metamorphosis different ecdysone target tissues express different isoform combinations in a manner consistent with the proposition that the different metamorphic responses of these tissues require different combinations of the EcR isoforms.	Ecdysone	105-113	Ecdysone receptor	Drosophila melanogaster	308-311
8355263-4	1993	The toxicity of phenobarbital was shown to be decreased by the cytochrome P-450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with aminophylline--the indirect enhancer of ecdysone production in the larval prothoracic gland.	Ecdysone	129-137	Cytochrome P450-9b2	Drosophila melanogaster	63-79
1936956-3	1991	RNA blot analysis showed that the rbp function of the BR-C is required for the transcription of six genes in the 71E late puff and is the first demonstration that an ecdysone-induced early gene controls the transcription of late genes within the puffing cascade.	Ecdysone	166-174	RIM-binding protein	Drosophila melanogaster	34-37
1327536-5	1992	Cotransfection of both EcR and usp expression vectors is required to render cultured mammalian cells ecdysone responsive.	Ecdysone	101-109	Ecdysone receptor	Drosophila melanogaster	23-26
1327536-5	1992	Cotransfection of both EcR and usp expression vectors is required to render cultured mammalian cells ecdysone responsive.	Ecdysone	101-109	ultraspiracle	Drosophila melanogaster	31-34
1572533-6	1992	Furthermore, ecd1 larvae cultured at the non-permissive temperature show a prominent puff at the 3C11-12 polytene bands, indicating that ecdysone is not essential for puff induction and that puff size is not simply correlated with high-level Sgs-4 transcription.	Ecdysone	137-145	ecdysoneless	Drosophila melanogaster	13-17
8485519-7	1993	For example, the Inr protects basal expression of Eip28/29 from the silencing effect of ecdysone response elements.	Ecdysone	88-96	Methionine sulfoxide reductase A	Drosophila melanogaster	50-58
1295740-1	1992	The Drosophila genes Eip28/29 and Eip40 are expressed in Kc cells and are rapidly induced by the steroid hormone ecdysone.	Ecdysone	113-121	Methionine sulfoxide reductase A	Drosophila melanogaster	21-29
1295740-1	1992	The Drosophila genes Eip28/29 and Eip40 are expressed in Kc cells and are rapidly induced by the steroid hormone ecdysone.	Ecdysone	113-121	Ecdysone-induced protein 55E	Drosophila melanogaster	34-39
1295740-5	1992	However high-level Eip28/29 expression always correlates with the presence of ecdysone and there is good evidence that Eip28/29 is directly regulated by the hormone in some tissues and at some stages.	Ecdysone	78-86	Methionine sulfoxide reductase A	Drosophila melanogaster	19-27
1295740-6	1992	Most striking are the induction of Eip28/29 transcripts in numerous tissues at the last larval molt, their induction in the epidermis at the time of the "late 3rd transition", their extinction in the same tissue by the premetamorphic ecdysone peak, and their induction by that peak in the lymph gland, hemocytes and proventriculus.	Ecdysone	234-242	Methionine sulfoxide reductase A	Drosophila melanogaster	35-43
1292892-3	1992	A 1.35 kb transcript from one of these genes, IMP-L1, is first observed in vivo at or just prior to pupariation, as ecdysone titers are peaking and beginning to decline.	Ecdysone	116-124	Ecdysone-inducible gene L1	Drosophila melanogaster	46-52
1913820-5	1991	Third, ecdysone-responsive cultured cells express EcR, whereas ecdysone-resistant cells derived from them are deficient in EcR.	Ecdysone	7-15	Ecdysone receptor	Drosophila melanogaster	50-53
1913820-5	1991	Third, ecdysone-responsive cultured cells express EcR, whereas ecdysone-resistant cells derived from them are deficient in EcR.	Ecdysone	63-71	Ecdysone receptor	Drosophila melanogaster	123-126
2044954-4	1991	Northern blot analysis of RNA isolated from staged animals or cultured organs was used to characterize the effects of ecdysone on E74 transcription.	Ecdysone	118-126	Ecdysone-induced protein 74EF	Drosophila melanogaster	130-133
1718680-10	1991	The peak of E74A protein induced by the late larval ecdysone pulse follows the peak of E74A mRNA by approximately 2 h. This delay is not seen in 10 h prepupae, when the next pulse of ecdysone induces the simultaneous expression of E74A mRNA and protein.	Ecdysone	52-60	Ecdysone-induced protein 74EF	Drosophila melanogaster	12-16
1718680-10	1991	The peak of E74A protein induced by the late larval ecdysone pulse follows the peak of E74A mRNA by approximately 2 h. This delay is not seen in 10 h prepupae, when the next pulse of ecdysone induces the simultaneous expression of E74A mRNA and protein.	Ecdysone	183-191	Ecdysone-induced protein 74EF	Drosophila melanogaster	12-16
1909425-8	1991	Transcription of the mutant yp3 gene can be induced in males by ecdysone.	Ecdysone	64-72	Yolk protein 3	Drosophila melanogaster	28-31
2044954-5	1991	Ecdysone directly activates both E74A and E74B promoters.	Ecdysone	0-8	Ecdysone-induced protein 74EF	Drosophila melanogaster	42-46
2044954-7	1991	The earlier appearance of E74B transcripts is enhanced by its activation at an approximately 25-fold lower ecdysone concentration than E74A.	Ecdysone	107-115	Ecdysone-induced protein 74EF	Drosophila melanogaster	26-30
2044954-8	1991	E74B is further distinguished from E74A by its repression at a significantly higher ecdysone concentration than that required for its induction, close to the concentration required for E74A activation.	Ecdysone	84-92	Ecdysone-induced protein 74EF	Drosophila melanogaster	0-4
2044954-9	1991	These regulatory properties lead to an ecdysone-induced switch in E74 expression, with an initial burst of E74B transcription followed by a burst of E74A transcription.	Ecdysone	39-47	Ecdysone-induced protein 74EF	Drosophila melanogaster	66-69
2044954-9	1991	These regulatory properties lead to an ecdysone-induced switch in E74 expression, with an initial burst of E74B transcription followed by a burst of E74A transcription.	Ecdysone	39-47	Ecdysone-induced protein 74EF	Drosophila melanogaster	107-111
2044954-10	1991	We also show that the patterns of ecdysone-induced E74A and E74B transcription vary in four ecdysone target tissues.	Ecdysone	34-42	Ecdysone-induced protein 74EF	Drosophila melanogaster	60-64
2044954-10	1991	We also show that the patterns of ecdysone-induced E74A and E74B transcription vary in four ecdysone target tissues.	Ecdysone	92-100	Ecdysone-induced protein 74EF	Drosophila melanogaster	60-64
1704862-4	1991	The hormone ecdysone leads to increased levels of hsr-omega transcripts in cultured cells, suggesting that changing ecdysone titers may play a role in the developmental changes of hsr-omega transcript levels.	Ecdysone	12-20	Heat shock RNA omega	Drosophila melanogaster	50-59
1704862-4	1991	The hormone ecdysone leads to increased levels of hsr-omega transcripts in cultured cells, suggesting that changing ecdysone titers may play a role in the developmental changes of hsr-omega transcript levels.	Ecdysone	12-20	Heat shock RNA omega	Drosophila melanogaster	180-189
1978245-1	1990	The E74 gene is one of a small set of early genes induced by the steroid hormone ecdysone at the onset of metamorphosis in the fruit fly, Drosophila melanogaster.	Ecdysone	81-89	Ecdysone-induced protein 74EF	Drosophila melanogaster	4-7
2016053-1	1991	The Drosophila melanogaster E74 gene is induced directly by the steroid hormone ecdysone and is a member of a small set of "early" genes that appear to trigger the onset of metamorphosis.	Ecdysone	80-88	Ecdysone-induced protein 74EF	Drosophila melanogaster	28-31
2016053-5	1991	Conserved characteristics of the E74 genes include ecdysone inducibility, localization to ecdysone-induced polytene chromosome puffs, and gene size.	Ecdysone	51-59	Ecdysone-induced protein 74EF	Drosophila melanogaster	33-36
2016053-5	1991	Conserved characteristics of the E74 genes include ecdysone inducibility, localization to ecdysone-induced polytene chromosome puffs, and gene size.	Ecdysone	90-98	Ecdysone-induced protein 74EF	Drosophila melanogaster	33-36
1899840-1	1991	Using an immunochemical approach, we have identified a unique antigen, PEP (protein on ecdysone puffs), which is associated in third-instar larvae with the active ecdysone-regulated loci on polytene chromosomes; PEP is not associated with most intermolt puffs and is found on some, but not all, heat shock-induced puffs.	Ecdysone	87-95	Protein on ecdysone puffs	Drosophila melanogaster	71-74
1899840-1	1991	Using an immunochemical approach, we have identified a unique antigen, PEP (protein on ecdysone puffs), which is associated in third-instar larvae with the active ecdysone-regulated loci on polytene chromosomes; PEP is not associated with most intermolt puffs and is found on some, but not all, heat shock-induced puffs.	Ecdysone	87-95	Protein on ecdysone puffs	Drosophila melanogaster	212-215
1846802-2	1991	Interestingly, a 3 bp substitution in the wild-type Hsp27 ecdysone response element (EcdRE) increases both its similarity with the vertebrate ERE and TRE/RRE and its capacity to confer ecdysone responsiveness to a heterologous promoter.	Ecdysone	58-66	Heat shock protein 27	Drosophila melanogaster	52-57
1846802-2	1991	Interestingly, a 3 bp substitution in the wild-type Hsp27 ecdysone response element (EcdRE) increases both its similarity with the vertebrate ERE and TRE/RRE and its capacity to confer ecdysone responsiveness to a heterologous promoter.	Ecdysone	185-193	Heat shock protein 27	Drosophila melanogaster	52-57
2208281-1	1990	The E74 early ecdysone-inducible gene plays a key role in the regulatory hierarchy activated by ecdysone at the onset of Drosophila metamorphosis.	Ecdysone	14-22	Ecdysone-induced protein 74EF	Drosophila melanogaster	4-7
2208281-5	1990	Antibody staining of larval salivary gland polytene chromosomes revealed that E74A protein binds to both early and late ecdysone-inducible puffs.	Ecdysone	120-128	Ecdysone-induced protein 74EF	Drosophila melanogaster	78-82
2109608-0	1990	Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider"s S3 cells.	Ecdysone	28-36	DNA segment, 16S	Mus musculus	45-48
2109608-4	1990	The RNA component of the 16S particles was identified by cDNA cloning using a cDNA library established from alpha ecdysone induced pupal 16S material.	Ecdysone	108-122	DNA segment, 16S	Mus musculus	25-28
2109608-4	1990	The RNA component of the 16S particles was identified by cDNA cloning using a cDNA library established from alpha ecdysone induced pupal 16S material.	Ecdysone	108-122	DNA segment, 16S	Mus musculus	137-140
2109608-5	1990	Northern hybridization using the 16S RNP specific partial cDNA clone Ec3 identifies a single alpha ecdysone inducible 300 nt RNA species.	Ecdysone	93-107	DNA segment, 16S	Mus musculus	33-36
1690603-1	1990	The E74 gene occupies one of the early puff loci (74EF) central to the Ashburner model for the ecdysone-induced puffing pattern in Drosophila.	Ecdysone	95-103	Ecdysone-induced protein 74EF	Drosophila melanogaster	4-7
1690603-2	1990	In support of this model, we show that the E74A promoter is directly activated by ecdysone and is subsequently repressed by ecdysone-induced proteins.	Ecdysone	82-90	Ecdysone-induced protein 74EF	Drosophila melanogaster	43-47
1690603-2	1990	In support of this model, we show that the E74A promoter is directly activated by ecdysone and is subsequently repressed by ecdysone-induced proteins.	Ecdysone	124-132	Ecdysone-induced protein 74EF	Drosophila melanogaster	43-47
2306250-2	1990	Forms 1, 2, 3, 5, and 6 catalyzed the formation of 20-hydroxy-ecdysone from ecdysone in the presence of NADPH and pig adrenal adrenodoxin and adrenodoxin reductase at rates not much different that observed in mitochondria; whereas, fraction 4 showed an activity which was about 10-fold higher than mitochondria.	Ecdysone	62-70	ferredoxin reductase	Sus scrofa	142-163
2107982-1	1990	We have isolated an ecdysone-inducible gene, E74, from the early puff at position 74EF in the Drosophila polytene chromosomes.	Ecdysone	20-28	Ecdysone-induced protein 74EF	Drosophila melanogaster	45-48
2107982-1	1990	We have isolated an ecdysone-inducible gene, E74, from the early puff at position 74EF in the Drosophila polytene chromosomes.	Ecdysone	20-28	Ecdysone-induced protein 74EF	Drosophila melanogaster	82-86
2315701-1	1990	Prothoracicotropic hormone (PTTH), a brain secretory polypeptide of insects, stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.	Ecdysone	134-142	prothoracicotropic hormone	Bombyx mori	0-26
2315701-1	1990	Prothoracicotropic hormone (PTTH), a brain secretory polypeptide of insects, stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.	Ecdysone	134-142	prothoracicotropic hormone	Bombyx mori	28-32
2106669-1	1990	The Broad-Complex (BR-C) of D. melanogaster, mapping at the 2B5 early ecdysone puff, mediates ecdysone-induced processes.	Ecdysone	70-78	broad	Drosophila melanogaster	60-63
2106669-1	1990	The Broad-Complex (BR-C) of D. melanogaster, mapping at the 2B5 early ecdysone puff, mediates ecdysone-induced processes.	Ecdysone	94-102	broad	Drosophila melanogaster	60-63
2106669-4	1990	The 2B5 region is actively transcribed in early third instar larvae before ecdysone levels increase.	Ecdysone	75-83	broad	Drosophila melanogaster	4-7
34648816-3	2022	E93 encodes a transcription factor that is specifically induced by the prepupal pulse of ecdysone, supporting a model proposed by earlier work that it specifies the onset of adult development.	Ecdysone	89-97	Ecdysone-induced protein 93F	Drosophila melanogaster	0-3
34975366-2	2021	In Drosophila melanogaster, prothoracicotropic hormone (PTTH)-releasing neurons are considered to be the primary promoting factor in ecdysone biosynthesis.	Ecdysone	133-141	Prothoracicotropic hormone	Drosophila melanogaster	56-60
34068603-3	2021	These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone).	Ecdysone	230-238	Adipokinetic hormone	Drosophila melanogaster	40-43
34469735-4	2021	Both Alk and Pvr trigger Ras/Erk signaling in the PG to upregulate expression of ecdysone biosynthetic enzymes, while Alk also suppresses autophagy by activating phosphatidylinositol 3-kinase (PI3K)/Akt.	Ecdysone	81-89	Anaplastic lymphoma kinase	Drosophila melanogaster	5-8
34469735-4	2021	Both Alk and Pvr trigger Ras/Erk signaling in the PG to upregulate expression of ecdysone biosynthetic enzymes, while Alk also suppresses autophagy by activating phosphatidylinositol 3-kinase (PI3K)/Akt.	Ecdysone	81-89	PDGF- and VEGF-receptor related	Drosophila melanogaster	13-16
34469735-4	2021	Both Alk and Pvr trigger Ras/Erk signaling in the PG to upregulate expression of ecdysone biosynthetic enzymes, while Alk also suppresses autophagy by activating phosphatidylinositol 3-kinase (PI3K)/Akt.	Ecdysone	81-89	rolled	Drosophila melanogaster	29-32
34429358-4	2021	H3K27me3 reduction induced by the down-regulation of PRC2 activity via inhibitor treatment in Bombyx or PG-specific knockdown of the PRC2 component Su(z)12 in Drosophila diminishes ecdysone biosynthesis and disturbs the larval-pupal transition.	Ecdysone	181-189	Su(z)12	Drosophila melanogaster	148-155
34296248-5	2021	Canonical ecdysone signaling typically involves the binding of Ecdysone receptor (EcR) and Ultraspiracle heterodimers to ecdysone-response elements (EcREs) within the promoters of responsive genes to drive expression.	Ecdysone	10-18	Ecdysone receptor	Drosophila melanogaster	63-80
34296248-5	2021	Canonical ecdysone signaling typically involves the binding of Ecdysone receptor (EcR) and Ultraspiracle heterodimers to ecdysone-response elements (EcREs) within the promoters of responsive genes to drive expression.	Ecdysone	10-18	Ecdysone receptor	Drosophila melanogaster	82-85
34296248-5	2021	Canonical ecdysone signaling typically involves the binding of Ecdysone receptor (EcR) and Ultraspiracle heterodimers to ecdysone-response elements (EcREs) within the promoters of responsive genes to drive expression.	Ecdysone	121-129	Ecdysone receptor	Drosophila melanogaster	63-80
34296248-5	2021	Canonical ecdysone signaling typically involves the binding of Ecdysone receptor (EcR) and Ultraspiracle heterodimers to ecdysone-response elements (EcREs) within the promoters of responsive genes to drive expression.	Ecdysone	121-129	Ecdysone receptor	Drosophila melanogaster	82-85
34788610-4	2021	AMPK is activated by ecdysone and promotes oxidative phosphorylation and pyruvate usage, likely to enable neurons to use noncarbohydrate metabolites such as amino acids for energy production.	Ecdysone	21-29	AMP-activated protein kinase alpha subunit	Drosophila melanogaster	0-4
34610327-3	2021	Artificially importing Ec in the tumor through the use of the EcI/Oatp74D importer aggravated cachexia, whereas feeding animals with Ec rescued cachectic defects.	Ecdysone	23-25	Organic anion transporting polypeptide 74D	Drosophila melanogaster	66-73
34610327-6	2021	The overexpression of Oatp33Eb in noncachectic tumors induced cachexia, whereas its inhibition in cachectic tumors restored circulating Ec and reversed cachectic alterations.	Ecdysone	136-138	Organic anion transporting polypeptide 33Eb	Drosophila melanogaster	22-30
34552169-5	2021	In Drosophila melanogaster different signals have been shown to regulate the production of ecdysone, such as PTTH/Torso, TGFss and Egfr signaling.	Ecdysone	91-99	Prothoracicotropic hormone	Drosophila melanogaster	109-113
34552169-5	2021	In Drosophila melanogaster different signals have been shown to regulate the production of ecdysone, such as PTTH/Torso, TGFss and Egfr signaling.	Ecdysone	91-99	Epidermal growth factor receptor	Drosophila melanogaster	131-135
34348164-5	2021	Nrf2-Keap1 signaling is activated downstream of the steroid hormone ecdysone.	Ecdysone	68-76	cap-n-collar	Drosophila melanogaster	0-4
34348164-5	2021	Nrf2-Keap1 signaling is activated downstream of the steroid hormone ecdysone.	Ecdysone	68-76	Keap1	Drosophila melanogaster	5-10
34068603-3	2021	These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone).	Ecdysone	230-238	Corazonin	Drosophila melanogaster	49-58
34068603-3	2021	These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone).	Ecdysone	230-238	Corazonin	Drosophila melanogaster	60-63
35086929-5	2022	This dual role for ecdysone explains how regeneration can still be completed successfully in dilp8- mutant larvae: higher ecdysone levels increase the regenerative activity of tissues, allowing regeneration to reach completion in a shorter time.	Ecdysone	19-27	Insulin-like peptide 8	Drosophila melanogaster	93-98
35523813-4	2022	A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons.	Ecdysone	15-23	Odorant receptor 22b	Drosophila melanogaster	151-170
35514223-2	2022	The insect steroid hormone 20-hydroxyecdysone (20E), is converted from ecdysone by the cytochrome P450 enzyme shade (CYP314A1), and it exerts potent effect on the induction and maintenance of diapause in obligatory diapause insects.	Ecdysone	71-79	shade	Drosophila melanogaster	117-125
35411705-2	2022	As a member of the low-density lipoprotein receptor (LDLR) family, megalin (mgl) is involved in the lipoprotein transport of cholesterol which is an essential precursor for the synthesis of ecdysone.	Ecdysone	190-198	Megalin	Drosophila melanogaster	76-79
35086929-5	2022	This dual role for ecdysone explains how regeneration can still be completed successfully in dilp8- mutant larvae: higher ecdysone levels increase the regenerative activity of tissues, allowing regeneration to reach completion in a shorter time.	Ecdysone	122-130	Insulin-like peptide 8	Drosophila melanogaster	93-98
2512110-1	1989	The temperature-sensitive mutation 1(3)ecd1 of Drosophila melanogaster is known to autonomously impair the ability of the larval prothoracic gland to produce the steroid molting hormone ecdysone in response to stimulation by the tropic neuropeptide prothoracicotropic hormone.	Ecdysone	186-194	ecdysoneless	Drosophila melanogaster	39-43
34842272-5	2022	Here, we show that JAK/STAT is active during development of the prothoracic gland (PG), the organ that controls metamorphosis onset through ecdysone production.	Ecdysone	140-148	hopscotch	Drosophila melanogaster	19-22
3130628-7	1988	Analysis of Schneider L3 cells indicates that the addition of the Drosophila hormone ecdysone, which induces differentiation of the cells, causes a small but reproducible increase in the level of the IDE and the insulin-degrading activity.	Ecdysone	85-93	Insulin degrading metalloproteinase	Drosophila melanogaster	200-203
2500282-6	1989	When Kc cells are treated with ecdysone in the presence of either natural JHs or synthetic analogues, the morphological and proliferative responses are inhibited and AChE induction is blocked.	Ecdysone	31-39	Acetylcholine esterase	Drosophila melanogaster	166-170
2843403-1	1988	We describe our analysis of IMP-L2, one of a set of six ecdysone-inducible genes in imaginal discs of Drosophila whose transcripts are associated with membrane-bound polysomes.	Ecdysone	56-64	Ecdysone-inducible gene L2	Drosophila melanogaster	28-34
3130628-7	1988	Analysis of Schneider L3 cells indicates that the addition of the Drosophila hormone ecdysone, which induces differentiation of the cells, causes a small but reproducible increase in the level of the IDE and the insulin-degrading activity.	Ecdysone	85-93	Insulin-like receptor	Drosophila melanogaster	212-219
3350119-3	1988	Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450.	Ecdysone	33-41	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	83-99
16453813-0	1987	An ecdysone response element in the Drosophila hsp27 promoter.	Ecdysone	3-11	Heat shock protein 27	Drosophila melanogaster	47-52
28305710-5	1987	We show that insulin triggers a reactivation of the neuroendocrine system leading to a neosynthesis of ecdysone beginning 6 days after treatment.	Ecdysone	103-111	insulin	Bos taurus	13-20
28304835-6	1974	The inhibitory effect could however be neutralized by the addition of alpha-methyl-D-glucopyranose in the medium or prevented by pre-treating the discs in a 0.1% trypsin solution for 2 min.In the presence of neuraminidase, discs evaginated normally under the influence of alpha-ecdysone; in a few cases, neuraminidase caused partial evagination in the absence of moulting hormone.After treatment by a 0.1% trypsin solution for 2 min, discs evaginated normally under the influence of the moulting hormone; whereas in the absence of ecdysone, evagination was never observed.	Ecdysone	272-286	neuraminidase 1	Homo sapiens	208-221
3099283-1	1986	The Drosophila Eip28/29 gene encodes two primary translation products, ecdysone-inducible polypeptide (EIP) 28III and EIP 29III.	Ecdysone	71-79	Methionine sulfoxide reductase A	Drosophila melanogaster	15-23
6714648-5	1984	Five picograms of PTTH directly stimulated the prothoracic glands in vitro so as to enhance ecdysone release.	Ecdysone	92-100	prothoracicotropic hormone	Bombyx mori	18-22
3123886-0	1987	Separate DNA sequences are required for normal female and ecdysone-induced male expression of Drosophila melanogaster yolk protein 1.	Ecdysone	58-66	Yolk protein 1	Drosophila melanogaster	118-132
16593512-2	1984	Radioimmunoassay with different antisera indicated that LP1 and LP2 are side-chain-modified analogues of ecdysone.	Ecdysone	105-113	Ribosomal protein LP2	Drosophila melanogaster	64-67
28304835-6	1974	The inhibitory effect could however be neutralized by the addition of alpha-methyl-D-glucopyranose in the medium or prevented by pre-treating the discs in a 0.1% trypsin solution for 2 min.In the presence of neuraminidase, discs evaginated normally under the influence of alpha-ecdysone; in a few cases, neuraminidase caused partial evagination in the absence of moulting hormone.After treatment by a 0.1% trypsin solution for 2 min, discs evaginated normally under the influence of the moulting hormone; whereas in the absence of ecdysone, evagination was never observed.	Ecdysone	278-286	neuraminidase 1	Homo sapiens	208-221
33205532-0	2021	The receptor tyrosine kinase torso regulates ecdysone homeostasis to control developmental timing in Bombyx mori.	Ecdysone	45-53	tyrosine-protein kinase receptor torso	Bombyx mori	29-34
32482109-8	2020	Ecdysone induced miR-275-3p and miR-305-5p through the ecdysone response effectors (EcREs) at the upstream of the pre-miR-275 cluster.	Ecdysone	0-8	mir-305 stem loop	Drosophila melanogaster	32-39
32482109-8	2020	Ecdysone induced miR-275-3p and miR-305-5p through the ecdysone response effectors (EcREs) at the upstream of the pre-miR-275 cluster.	Ecdysone	0-8	mir-275 stem loop	Drosophila melanogaster	17-24
32482109-8	2020	Ecdysone induced miR-275-3p and miR-305-5p through the ecdysone response effectors (EcREs) at the upstream of the pre-miR-275 cluster.	Ecdysone	55-63	mir-305 stem loop	Drosophila melanogaster	32-39
32482109-8	2020	Ecdysone induced miR-275-3p and miR-305-5p through the ecdysone response effectors (EcREs) at the upstream of the pre-miR-275 cluster.	Ecdysone	55-63	mir-275 stem loop	Drosophila melanogaster	17-24
32675276-5	2020	Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size.	Ecdysone	262-270	Neuropeptide F receptor	Drosophila melanogaster	26-49
32675276-5	2020	Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size.	Ecdysone	262-270	Neuropeptide F receptor	Drosophila melanogaster	51-55
32675276-5	2020	Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size.	Ecdysone	262-270	Neuropeptide F receptor	Drosophila melanogaster	196-200
32009293-5	2020	Specifically, we found that a secreted protein, NimB5, is produced in the fat body upon nutrient scarcity downstream of metabolic sensors and ecdysone signaling.	Ecdysone	142-150	Nimrod B5	Drosophila melanogaster	48-53
32726635-7	2020	Our work characterizes Bab2 as a temporal regulator of somatic gene expression in response to systemic ecdysone signaling.	Ecdysone	103-111	bric a brac 2	Drosophila melanogaster	23-27
32631830-7	2020	Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development.	Ecdysone	74-82	Ecdysone receptor	Drosophila melanogaster	103-106
32631830-7	2020	Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development.	Ecdysone	74-82	Prothoracicotropic hormone	Drosophila melanogaster	123-127
32631830-7	2020	Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development.	Ecdysone	184-192	Ecdysone receptor	Drosophila melanogaster	103-106
32631830-7	2020	Our findings indicate the existence of a feedback circuit in which rising ecdysone levels trigger, via EcR activity in the PTTHn, the PTTH surge that generates the maturation-inducing ecdysone peak toward the end of larval development.	Ecdysone	184-192	Prothoracicotropic hormone	Drosophila melanogaster	123-127
32461236-4	2020	Chronic administration of aldosterone or ecdysone induces expression and accumulation of collagen-like Pericardin at adult nephrocytes - podocyte-like cells that filter circulating hemolymph.	Ecdysone	41-49	Multiplexin	Drosophila melanogaster	89-102
32676099-15	2020	From these results, we propose that Pabp regulates subcellular localization in the PG, specifically of the transcription factor Mld, in the context of ecdysone biosynthesis.	Ecdysone	151-159	poly(A) binding protein	Drosophila melanogaster	36-40
32676099-15	2020	From these results, we propose that Pabp regulates subcellular localization in the PG, specifically of the transcription factor Mld, in the context of ecdysone biosynthesis.	Ecdysone	151-159	molting defective	Drosophila melanogaster	128-131
32461236-4	2020	Chronic administration of aldosterone or ecdysone induces expression and accumulation of collagen-like Pericardin at adult nephrocytes - podocyte-like cells that filter circulating hemolymph.	Ecdysone	41-49	pericardin	Drosophila melanogaster	103-113
32461236-10	2020	Here we find the steroids ecdysone and aldosterone require dEGFR in cardiomyocytes to induce fibrosis of the cardiac-renal system.	Ecdysone	26-34	Epidermal growth factor receptor	Drosophila melanogaster	59-64
32207238-3	2020	Dendrite pruning requires local cytoskeleton remodeling, and the actin-severing enzyme Mical is an important ecdysone target.	Ecdysone	109-117	Molecule interacting with CasL	Drosophila melanogaster	87-92
32196731-6	2020	In addition, miR-8-3p was expressed in the prothoracic gland (PG), which produces and releases ecdysone in response to prothoracicotropic hormone (PTTH).	Ecdysone	95-103	Prothoracicotropic hormone	Drosophila melanogaster	147-151
32196731-7	2020	Notably, overexpression of miR-8-3p or knockdown of its Vha targets in the PG resulted in larger than normal, ecdysone-deficient larvae that failed to develop into the pupal stage but could be rescued by ecdysone feeding.	Ecdysone	110-118	Vacuolar H[+] ATPase 68kD subunit 1	Drosophila melanogaster	56-59
32196731-10	2020	Consequently, our data indicate that the coordinated regulation of V-ATPase subunits by miR-8-3p is involved in Drosophila metamorphosis by controlling the ecdysone biosynthesis.	Ecdysone	156-164	Vacuolar H[+]-ATPase SFD subunit	Drosophila melanogaster	67-75
32179799-4	2020	Many proteins identified through proximity-dependent labelling with EcR/Usp were described previously as functional components of an ecdysone response, corroborating the potency of this labelling method.	Ecdysone	133-141	Ecdysone receptor	Drosophila melanogaster	68-71
32220314-0	2020	Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland.	Ecdysone	39-47	Epidermal growth factor receptor	Drosophila melanogaster	0-4
32220314-5	2020	It is widely accepted that ecdysone biosynthesis in Drosophila is mainly induced by the activation of tyrosine kinase (RTK) Torso by the prothoracicotropic hormone (Ptth) produced into two pairs of neurosecretory cells that project their axons onto the PG [7, 8].	Ecdysone	27-35	Tie-like receptor tyrosine kinase	Drosophila melanogaster	119-122
32220314-5	2020	It is widely accepted that ecdysone biosynthesis in Drosophila is mainly induced by the activation of tyrosine kinase (RTK) Torso by the prothoracicotropic hormone (Ptth) produced into two pairs of neurosecretory cells that project their axons onto the PG [7, 8].	Ecdysone	27-35	Prothoracicotropic hormone	Drosophila melanogaster	165-169
32220314-7	2020	Here, we show that Egfr signaling, rather than Ptth/torso, is the major contributor of ecdysone biosynthesis in Drosophila.	Ecdysone	87-95	Epidermal growth factor receptor	Drosophila melanogaster	19-23
32220314-9	2020	This regulatory positive feedback loop ensures the production of ecdysone to trigger metamorphosis by a progressive Egfr-dependent activation of MAPK/ERK pathway, thus determining the animal final body size.	Ecdysone	65-73	Epidermal growth factor receptor	Drosophila melanogaster	116-120
32179799-4	2020	Many proteins identified through proximity-dependent labelling with EcR/Usp were described previously as functional components of an ecdysone response, corroborating the potency of this labelling method.	Ecdysone	133-141	ultraspiracle	Drosophila melanogaster	72-75
32179799-5	2020	A link to ecdysone response was confirmed for some newly discovered regulators by immunoprecipitation of prepupal nuclear extract with anti-EcR antibodies and functional experiments in Drosophila S2 cells.	Ecdysone	10-18	Ecdysone receptor	Drosophila melanogaster	140-143
31955616-3	2020	The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor for the catecholamine dopamine and the steroid hormone ecdysone.	Ecdysone	142-150	Ecdysone receptor	Drosophila melanogaster	20-40
31955616-3	2020	The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor for the catecholamine dopamine and the steroid hormone ecdysone.	Ecdysone	142-150	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	42-48
31641960-2	2019	Previously we have shown that a group of corazonin-producing peptidergic neurons (vCrz) undergo apoptosis in response to ecdysone signaling via ecdysone receptor (EcR)-B isoforms and Ultraspiracle during early phase of metamorphosis.	Ecdysone	121-129	Ecdysone receptor	Drosophila melanogaster	144-169
31862793-5	2019	Our studies show that KDM5 functions by promoting the endoreplication of prothoracic gland cells, a process that increases ploidy and is rate limiting for the expression of ecdysone biosynthetic genes.	Ecdysone	173-181	little imaginal discs	Drosophila melanogaster	22-26
31928869-3	2020	Recently, however, we challenged the simple diffusion model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake of the primary insect steroid hormone ecdysone [2].	Ecdysone	151-159	Organic anion transporting polypeptide 58Dc	Drosophila melanogaster	89-127
31928869-3	2020	Recently, however, we challenged the simple diffusion model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake of the primary insect steroid hormone ecdysone [2].	Ecdysone	151-159	Organic anion transporting polypeptide 58Dc	Drosophila melanogaster	129-133
31928869-3	2020	Recently, however, we challenged the simple diffusion model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake of the primary insect steroid hormone ecdysone [2].	Ecdysone	246-254	Organic anion transporting polypeptide 58Dc	Drosophila melanogaster	89-127
31928869-3	2020	Recently, however, we challenged the simple diffusion model by showing that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake of the primary insect steroid hormone ecdysone [2].	Ecdysone	246-254	Organic anion transporting polypeptide 58Dc	Drosophila melanogaster	129-133
31415125-3	2019	RESULTS: Overexpression of activated Ras in developing eye/wing discs inhibited Ptth expression in brain via upregulated JNK signaling mediated Dilp8 secretion from imaginal discs, which inhibited ecdysone synthesis in prothoracic gland after pupariation, leading to death of ~25- to 30-hour-old pupae.	Ecdysone	197-205	Prothoracicotropic hormone	Drosophila melanogaster	80-84
31415125-3	2019	RESULTS: Overexpression of activated Ras in developing eye/wing discs inhibited Ptth expression in brain via upregulated JNK signaling mediated Dilp8 secretion from imaginal discs, which inhibited ecdysone synthesis in prothoracic gland after pupariation, leading to death of ~25- to 30-hour-old pupae.	Ecdysone	197-205	basket	Drosophila melanogaster	121-124
31415125-3	2019	RESULTS: Overexpression of activated Ras in developing eye/wing discs inhibited Ptth expression in brain via upregulated JNK signaling mediated Dilp8 secretion from imaginal discs, which inhibited ecdysone synthesis in prothoracic gland after pupariation, leading to death of ~25- to 30-hour-old pupae.	Ecdysone	197-205	Insulin-like peptide 8	Drosophila melanogaster	144-149
31184522-0	2019	microRNA-14 as an efficient suppressor to switch off ecdysone production after ecdysis in insects.	Ecdysone	53-61	microRNA 14	Bombyx mori	0-11
31589603-4	2019	Here, we demonstrate that BMP-mediated SC growth is dependent on the receptor for the developmental steroid ecdysone, whose concentration is reported to reflect sociosexual experience in adults.	Ecdysone	108-116	decapentaplegic	Drosophila melanogaster	26-29
31563631-4	2019	Using two publicly available transgenic collections (the FlyLight and Vienna Tiles resources), we tested 62 Gal4 drivers corresponding to ecdysone-response genes EcR, usp, E75, br, ftz-f1 and Hr3.	Ecdysone	138-146	Ecdysone receptor	Drosophila melanogaster	162-165
31563631-4	2019	Using two publicly available transgenic collections (the FlyLight and Vienna Tiles resources), we tested 62 Gal4 drivers corresponding to ecdysone-response genes EcR, usp, E75, br, ftz-f1 and Hr3.	Ecdysone	138-146	ultraspiracle	Drosophila melanogaster	167-170
31283922-0	2019	Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development.	Ecdysone	58-66	eukaryotic translation initiation factor 6	Drosophila melanogaster	11-15
31283922-6	2019	We generated a Drosophila melanogaster model of eIF6 upregulation, leading to a boost in general translation and the shut-down of the ecdysone biosynthetic pathway.	Ecdysone	134-142	eukaryotic translation initiation factor 6	Drosophila melanogaster	48-52
31283922-8	2019	In vivo, eIF6-driven alterations delayed Programmed Cell Death (PCD), resulting in aberrant phenotypes, partially rescued by ecdysone administration.	Ecdysone	125-133	eukaryotic translation initiation factor 6	Drosophila melanogaster	9-13
31484080-0	2019	Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.	Ecdysone	0-8	pipsqueak	Drosophila melanogaster	80-89
31484080-0	2019	Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.	Ecdysone	0-8	Polycomb	Drosophila melanogaster	94-102
31019084-0	2019	Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila.	Ecdysone	85-93	Ecdysone receptor	Drosophila melanogaster	52-55
31152978-11	2019	Furthermore, alpha-ecdysone increased HO-1 and nuclear factor erythroid 2-related factor (Nrf2) production, mitigated NF-kappaB subunit proteins in the nucleus and decreased MAPKs and Akt activation.	Ecdysone	13-27	heme oxygenase 1	Mus musculus	38-88
31152978-11	2019	Furthermore, alpha-ecdysone increased HO-1 and nuclear factor erythroid 2-related factor (Nrf2) production, mitigated NF-kappaB subunit proteins in the nucleus and decreased MAPKs and Akt activation.	Ecdysone	13-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
31152978-12	2019	These results suggest that alpha-ecdysone is a good immunostimulator with anti-inflammatory effects that occur via inhibition of pro-inflammatory mediators and cytokines through stimulation of HO-1 and Nrf-2 production.	Ecdysone	27-41	heme oxygenase 1	Mus musculus	193-197
31152978-12	2019	These results suggest that alpha-ecdysone is a good immunostimulator with anti-inflammatory effects that occur via inhibition of pro-inflammatory mediators and cytokines through stimulation of HO-1 and Nrf-2 production.	Ecdysone	27-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	202-207
31152978-0	2019	alpha-Ecdysone suppresses inflammatory responses via the Nrf2 pathway in lipopolysaccharide-stimulated RAW 264.7 cells.	Ecdysone	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
31019084-5	2019	In particular, EcR initiates a cascade of transcription factor expression in response to ecdysone, making it unclear which ecdysone-responsive genes are direct EcR targets.	Ecdysone	89-97	Ecdysone receptor	Drosophila melanogaster	15-18
30396233-5	2018	MKRN1 was expressed in the prothoracic gland, where the steroid hormone ecdysone is produced.	Ecdysone	72-80	Makorin 1	Drosophila melanogaster	0-5
29959404-7	2019	Furthermore, Dpp signaling in the midgut prevents the expression of ecdysone responsive genes and impairs ecdysone production in the prothoracic gland.	Ecdysone	68-76	decapentaplegic	Drosophila melanogaster	13-16
29959404-7	2019	Furthermore, Dpp signaling in the midgut prevents the expression of ecdysone responsive genes and impairs ecdysone production in the prothoracic gland.	Ecdysone	106-114	decapentaplegic	Drosophila melanogaster	13-16
31487710-8	2019	In vitro analysis with cultured testes revealed that expression levels of Bmdsx were increased in a dose-dependent manner of the ecdysone analog, ponasterone A.	Ecdysone	129-137	doublesex	Bombyx mori	74-79
31487710-9	2019	These results suggest that ecdysone signaling may play a role in indirectly regulating the expression of some genes involved in sexual differentiation through inducing expression of Bmdsx in the silkworm.	Ecdysone	27-35	doublesex	Bombyx mori	182-187
30396233-7	2018	Collectively, these results indicate that MKRN1 fine-tunes developmental timing and sexual maturation by affecting ecdysone synthesis in Drosophila.	Ecdysone	115-123	Makorin 1	Drosophila melanogaster	42-47
30515478-5	2018	Dpp from peripheral tissues, mostly imaginal discs, can reach the PG and inhibit ecdysone biosynthesis.	Ecdysone	81-89	decapentaplegic	Drosophila melanogaster	0-3
30446615-12	2018	Interestingly, the VDR is homologous to the daf-12 and ecdysone NRs that regulate dormancy in Caenorhabditis elegans and Drosophila We suggest that 7-DHC-derived hormones and their associated NRs represent a conserved pathway for the integration of environmental information into developmental programs associated with life history transitions in animals.	Ecdysone	55-63	beethoven	Drosophila melanogaster	150-153
29908237-8	2018	This faster transition correlates with increased levels of ecdysone direct target genes such as Broad-Complex (BR-C) and Ecdysone Receptor (EcR).	Ecdysone	59-67	Ecdysone receptor	Drosophila melanogaster	121-138
29908237-8	2018	This faster transition correlates with increased levels of ecdysone direct target genes such as Broad-Complex (BR-C) and Ecdysone Receptor (EcR).	Ecdysone	59-67	Ecdysone receptor	Drosophila melanogaster	140-143
30149007-4	2018	We report here that CCR4-NOT has an essential function in the Drosophila prothoracic gland (PG), a tissue that predominantly produces the steroid hormone ecdysone.	Ecdysone	154-162	twin	Drosophila melanogaster	20-24
30149007-6	2018	Transcriptome analysis of PG-specific Pop2-RNAi samples revealed that Pop2 is required for the normal expression of ecdysone biosynthetic gene spookier (spok) as well as cholesterol homeostasis genes of the NPC2 family.	Ecdysone	116-124	Pop2	Drosophila melanogaster	38-42
30149007-6	2018	Transcriptome analysis of PG-specific Pop2-RNAi samples revealed that Pop2 is required for the normal expression of ecdysone biosynthetic gene spookier (spok) as well as cholesterol homeostasis genes of the NPC2 family.	Ecdysone	116-124	Pop2	Drosophila melanogaster	70-74
30149007-6	2018	Transcriptome analysis of PG-specific Pop2-RNAi samples revealed that Pop2 is required for the normal expression of ecdysone biosynthetic gene spookier (spok) as well as cholesterol homeostasis genes of the NPC2 family.	Ecdysone	116-124	spookier	Drosophila melanogaster	153-157
30149007-7	2018	Interestingly, dietary supplementation with ecdysone and its various sterol precursors showed that 7-dehydrocholesterol and cholesterol completely rescued the larval arrest phenotype, allowing Pop2-RNAi animals to reach pupal stage, and, to a low degree, even survival to adulthood, while the biologically active hormone, 20-Hydroxyecdysone (20E), was significantly less effective.	Ecdysone	44-52	Pop2	Drosophila melanogaster	193-197
30149809-8	2018	Moreover, only 52.65% EcR peaks contained ecdysone response element (EcRE) motif, suggesting that EcR regulates the expression of target genes not only by binding directly to EcRE, but also by binding with other transcription factor.	Ecdysone	42-50	ecdysone receptor	Bombyx mori	22-25
30157424-2	2018	In addition, ecdysone activates the eukaryotic initiation factor 4E-binding protein (4E-BP) to inhibit cap-dependent translation initiation.	Ecdysone	13-21	thor	Drosophila melanogaster	85-90
30157424-5	2018	eIF4A and eIF3 are stringently required for translation of the ecdysone target Mical, and this depends on the 5" UTR of Mical mRNA.	Ecdysone	63-71	eukaryotic translation initiation factor 4A	Drosophila melanogaster	0-5
30157424-5	2018	eIF4A and eIF3 are stringently required for translation of the ecdysone target Mical, and this depends on the 5" UTR of Mical mRNA.	Ecdysone	63-71	eukaryotic translation initiation factor 3 subunit g1	Drosophila melanogaster	10-14
30157424-5	2018	eIF4A and eIF3 are stringently required for translation of the ecdysone target Mical, and this depends on the 5" UTR of Mical mRNA.	Ecdysone	63-71	Molecule interacting with CasL	Drosophila melanogaster	79-84
30157424-5	2018	eIF4A and eIF3 are stringently required for translation of the ecdysone target Mical, and this depends on the 5" UTR of Mical mRNA.	Ecdysone	63-71	Molecule interacting with CasL	Drosophila melanogaster	120-125
30157424-7	2018	We propose that an eIF3-eIF4A-dependent alternative initiation pathway bypasses 4E-BP to ensure adequate translation of ecdysone-induced genes.	Ecdysone	120-128	eukaryotic translation initiation factor 3 subunit g1	Drosophila melanogaster	19-23
30157424-7	2018	We propose that an eIF3-eIF4A-dependent alternative initiation pathway bypasses 4E-BP to ensure adequate translation of ecdysone-induced genes.	Ecdysone	120-128	eukaryotic translation initiation factor 4A	Drosophila melanogaster	24-29
30157424-7	2018	We propose that an eIF3-eIF4A-dependent alternative initiation pathway bypasses 4E-BP to ensure adequate translation of ecdysone-induced genes.	Ecdysone	120-128	thor	Drosophila melanogaster	80-85
30149809-8	2018	Moreover, only 52.65% EcR peaks contained ecdysone response element (EcRE) motif, suggesting that EcR regulates the expression of target genes not only by binding directly to EcRE, but also by binding with other transcription factor.	Ecdysone	42-50	ecdysone receptor	Bombyx mori	69-72
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	67-72
30111886-0	2018	Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3beta pathway signaling.	Ecdysone	44-52	nuclear receptor subfamily 3, group C, member 2	Mus musculus	14-40
30111886-0	2018	Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3beta pathway signaling.	Ecdysone	44-52	glycogen synthase kinase 3 alpha	Mus musculus	159-167
30111886-5	2018	To explore the molecular target responsible for the pathogenic actions, we employed an in silico modeling system of compound-protein interaction and identified mineralocorticoid receptor (MR) as one of the top-ranking proteins with putative interactions with ecdysone.	Ecdysone	259-267	nuclear receptor subfamily 3, group C, member 2	Mus musculus	160-186
30111886-10	2018	Altogether, ecdysone seems able to activate MR and thereby promote glomerular injury and proteinuria involving overactive GSK3beta pathway signaling.	Ecdysone	12-20	glycogen synthase kinase 3 alpha	Mus musculus	122-130
30262999-2	2018	In this study, we found that ecdysone oxidase (EO) gene, which encodes an enzyme to catalyze ecdysone (or 20-hydroxyecdysone, 20E) to 3-dehydroecdysone (3DE), was highly expressed in the mature ovaries of the domestic silkworm, Bombyx mori.	Ecdysone	29-37	ecdysone oxidase	Bombyx mori	47-49
29543534-7	2018	Overall, our data suggest a potential role for the ecdysone/miR-252-5p/Abi regulatory axis partly in cell-cycle control during metamorphosis in Drosophila.-Lim, D.-H., Lee, S., Han, J. Y., Choi, M.-S., Hong, J.-S., Seong, Y., Kwon, Y.-S., Lee, Y. S. Ecdysone-responsive microR-252-5p controls the cell cycle by targeting Abi in Drosophila.	Ecdysone	250-258	ecdysoneless	Drosophila melanogaster	51-59
29543534-7	2018	Overall, our data suggest a potential role for the ecdysone/miR-252-5p/Abi regulatory axis partly in cell-cycle control during metamorphosis in Drosophila.-Lim, D.-H., Lee, S., Han, J. Y., Choi, M.-S., Hong, J.-S., Seong, Y., Kwon, Y.-S., Lee, Y. S. Ecdysone-responsive microR-252-5p controls the cell cycle by targeting Abi in Drosophila.	Ecdysone	250-258	mir-252 stem loop	Drosophila melanogaster	60-67
29543534-7	2018	Overall, our data suggest a potential role for the ecdysone/miR-252-5p/Abi regulatory axis partly in cell-cycle control during metamorphosis in Drosophila.-Lim, D.-H., Lee, S., Han, J. Y., Choi, M.-S., Hong, J.-S., Seong, Y., Kwon, Y.-S., Lee, Y. S. Ecdysone-responsive microR-252-5p controls the cell cycle by targeting Abi in Drosophila.	Ecdysone	250-258	Abelson interacting protein	Drosophila melanogaster	71-74
29567866-0	2018	Kruppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.	Ecdysone	35-43	Kruppel homolog 1	Drosophila melanogaster	0-17
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	48-65
29559251-5	2018	With a similar approach here we demonstrate that another member of the viral ank gene family, TnBVank3, does also contribute to the disruption of ecdysone biosynthesis, but with a completely different mechanism.	Ecdysone	146-154	Ankyrin	Drosophila melanogaster	77-80
29784791-6	2018	We delineate a pathway in which nutritional restriction increases levels of the steroid hormone ecdysone, which, in turn, triggers ecdysone signaling-dependent Imp-L2 production from the fat body, a fly adipose organ, thereby attenuating peripheral IIS and body growth.	Ecdysone	96-104	Ecdysone-inducible gene L2	Drosophila melanogaster	160-166
29855367-9	2018	In response to desiccation, ecdysone is produced in MTs and acts in a paracrine fashion to increase PGRP-LC expression, immune responsiveness, and improve host defense.	Ecdysone	28-36	Peptidoglycan recognition protein LC	Drosophila melanogaster	100-107
29467242-3	2018	The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis.	Ecdysone	160-168	Prothoracicotropic hormone	Drosophila melanogaster	17-43
29467242-3	2018	The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis.	Ecdysone	160-168	Prothoracicotropic hormone	Drosophila melanogaster	45-49
29567866-3	2018	Here, we demonstrate that the expression of the Kruppel homolog 1 (Kr-h1), a gene encoding a transcription factor that mediates JH signaling, in ecdysone-producing organ prothoracic gland (PG) represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx Application of a JH mimic on ex vivo cultured PGs from Drosophila and Bombyx larvae induces Kr-h1 expression and inhibits the transcription of steroidogenic enzymes.	Ecdysone	145-153	Kruppel homolog 1	Drosophila melanogaster	413-418
29567866-7	2018	Taken together, our data indicate direct and conserved Kr-h1 repression of insect ecdysone biosynthesis in response to JH stimulation, providing insights into mechanisms underlying the antagonistic roles of JH and ecdysone.	Ecdysone	82-90	Kruppel homolog 1	Drosophila melanogaster	55-60
29187506-4	2018	In this study, we report that three zinc finger-associated domain (ZAD)-C2H2 zinc finger transcription factors-Seance (Sean), Ouija board (Ouib), and Molting defective (Mld)-cooperatively control ecdysone biosynthesis in the fruit fly Drosophila melanogaster Sean and Ouib act in cooperation with Mld to positively regulate the transcription of neverland and spookier, respectively, two Halloween genes.	Ecdysone	196-204	molting defective	Drosophila melanogaster	169-172
29187506-4	2018	In this study, we report that three zinc finger-associated domain (ZAD)-C2H2 zinc finger transcription factors-Seance (Sean), Ouija board (Ouib), and Molting defective (Mld)-cooperatively control ecdysone biosynthesis in the fruit fly Drosophila melanogaster Sean and Ouib act in cooperation with Mld to positively regulate the transcription of neverland and spookier, respectively, two Halloween genes.	Ecdysone	196-204	molting defective	Drosophila melanogaster	297-300
29187506-0	2018	Cooperative Control of Ecdysone Biosynthesis in Drosophila by Transcription Factors Seance, Ouija Board, and Molting Defective.	Ecdysone	23-31	molting defective	Drosophila melanogaster	76-126
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	53-61	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	35-41
29382341-8	2018	CONCLUSIONS: Our findings indicate that, as a dual regulator of octopamine and juvenile hormone release, ETH provides a link between stress-induced elevation of ecdysone levels and consequent reduction in fecundity.	Ecdysone	161-169	Ecdysis triggering hormone	Drosophila melanogaster	105-108
29361557-4	2018	Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth.	Ecdysone	99-107	Chronologically inappropriate morphogenesis	Drosophila melanogaster	89-95
30227391-12	2018	Moreover, virtual screening based on compound-protein interaction profiles identified the Mineralocorticoid Receptor (MR) to potentially interact with ecdysone.	Ecdysone	151-159	nuclear receptor subfamily 3, group C, member 2	Mus musculus	90-116
30003888-6	2018	As ovaries are the main site of ecdysone production in females, we knocked down the receptor to ecdysone EcR in the oenocytes and obtained increased amounts of CHCs and inhibition of long chain CHC synthesis, showing that the lack of an ecdysone signal arriving into the oenocytes is responsible for these defects.	Ecdysone	32-40	Ecdysone receptor	Drosophila melanogaster	105-108
30003888-6	2018	As ovaries are the main site of ecdysone production in females, we knocked down the receptor to ecdysone EcR in the oenocytes and obtained increased amounts of CHCs and inhibition of long chain CHC synthesis, showing that the lack of an ecdysone signal arriving into the oenocytes is responsible for these defects.	Ecdysone	96-104	Ecdysone receptor	Drosophila melanogaster	105-108
30003888-9	2018	Together, these results support the notion of an interaction between oocyte and follicular cells, which send an ecdysone signal to the oenocytes to regulate CHC synthesis.	Ecdysone	112-120	Clathrin heavy chain	Drosophila melanogaster	157-160
29180716-3	2017	Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone.	Ecdysone	143-151	Insulin-like receptor	Drosophila melanogaster	10-17
29180716-3	2017	Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone.	Ecdysone	143-151	forkhead box, sub-group O	Drosophila melanogaster	18-22
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	53-61	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	210-216
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	53-61	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	210-216
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	144-152	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	35-41
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	144-152	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	210-216
28554773-7	2017	We then reveal that application of DopEcR"s ligands, ecdysone and dopamine, had different effects on nicotine-induced Ca2+-responses in the MB: ecdysone enhanced activity in the calyx and cell body region in a DopEcR-dependent manner, whereas dopamine reduced activity in the medial lobes independently of DopEcR.	Ecdysone	144-152	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	210-216
28922901-1	2017	The aldo-keto reductase AKR2E4 reduces 3-dehydroecdysone to ecdysone in the silkworm Bombyx mori L. In this study, a quantitative polymerase chain reaction analysis revealed that the level of AKR2E4 mRNA was higher in the testes than in other tissues, and a western immunoblot analysis revealed that the AKR2E4 content in the testes was stage-specific from the fifth larval instar to the pupal stage.	Ecdysone	48-56	aldo-keto reductase AKR2E4	Bombyx mori	24-30
28922901-1	2017	The aldo-keto reductase AKR2E4 reduces 3-dehydroecdysone to ecdysone in the silkworm Bombyx mori L. In this study, a quantitative polymerase chain reaction analysis revealed that the level of AKR2E4 mRNA was higher in the testes than in other tissues, and a western immunoblot analysis revealed that the AKR2E4 content in the testes was stage-specific from the fifth larval instar to the pupal stage.	Ecdysone	48-56	aldo-keto reductase AKR2E4	Bombyx mori	192-198
28922901-1	2017	The aldo-keto reductase AKR2E4 reduces 3-dehydroecdysone to ecdysone in the silkworm Bombyx mori L. In this study, a quantitative polymerase chain reaction analysis revealed that the level of AKR2E4 mRNA was higher in the testes than in other tissues, and a western immunoblot analysis revealed that the AKR2E4 content in the testes was stage-specific from the fifth larval instar to the pupal stage.	Ecdysone	48-56	aldo-keto reductase AKR2E4	Bombyx mori	192-198
28922901-3	2017	These results indicate that AKR2E4 plays an important role in 3-dehydroecdysone conversion to ecdysone and spermatogenesis in silkworm testes.	Ecdysone	71-79	aldo-keto reductase AKR2E4	Bombyx mori	28-34
28528906-5	2017	Here, we show that Warts (Wts; LATS1/2) signaling regulates systemic growth in Drosophila by activating basal ecdysone production, which negatively regulates body growth.	Ecdysone	110-118	warts	Drosophila melanogaster	26-29
28554773-0	2017	Modulation of neuronal activity in the Drosophila mushroom body by DopEcR, a unique dual receptor for ecdysone and dopamine.	Ecdysone	102-110	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	67-73
28554773-3	2017	Drosophila DopEcR is a GPCR that responds to both ecdysone (the major steroid hormone in insects) and dopamine, regulating multiple second messenger systems.	Ecdysone	50-58	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	11-17
28627423-6	2017	In PTTH knockout larvae, peak levels of ecdysone titers in the hemolymph were dramatically reduced and the timing of peaks was delayed, suggesting that protracted larval development is a result of the reduced and delayed synthesis of ecdysone in the PG.	Ecdysone	40-48	prothoracicotropic hormone	Bombyx mori	3-7
28627423-6	2017	In PTTH knockout larvae, peak levels of ecdysone titers in the hemolymph were dramatically reduced and the timing of peaks was delayed, suggesting that protracted larval development is a result of the reduced and delayed synthesis of ecdysone in the PG.	Ecdysone	234-242	prothoracicotropic hormone	Bombyx mori	3-7
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	43-51	prothoracicotropic hormone	Bombyx mori	71-75
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133
28627423-7	2017	Despite these defects, low basal levels of ecdysone were maintained in PTTH knockout larvae, suggesting that the primary role of PTTH is to upregulate ecdysone biosynthesis in the PG during molting stages, and low basal levels of ecdysone can be maintained in the absence of PTTH.	Ecdysone	151-159	prothoracicotropic hormone	Bombyx mori	129-133
28627423-8	2017	We also found that mRNA levels of genes involved in ecdysone biosynthesis and ecdysteroid signaling pathways were significantly reduced in PTTH knockouts.	Ecdysone	52-60	prothoracicotropic hormone	Bombyx mori	139-143
28680812-1	2017	Synthetic nonsteroidal ecdysone agonists, a class of insect growth regulators (IGRs), target the ecdysone receptor (EcR), which forms a heterodimer with ultraspiracle (USP) to transactivate ecdysone response genes.	Ecdysone	23-31	Ecdysone receptor	Drosophila melanogaster	116-119
28680812-1	2017	Synthetic nonsteroidal ecdysone agonists, a class of insect growth regulators (IGRs), target the ecdysone receptor (EcR), which forms a heterodimer with ultraspiracle (USP) to transactivate ecdysone response genes.	Ecdysone	23-31	ultraspiracle	Drosophila melanogaster	168-171
28680812-3	2017	In the present study, we developed reporter gene assay (RGA) systems to detect molting hormone (ecdysone) activity by introducing EcR-USP cDNA and a bacterial lacZ reporter gene into yeast.	Ecdysone	96-104	Regena	Drosophila melanogaster	56-59
28680812-3	2017	In the present study, we developed reporter gene assay (RGA) systems to detect molting hormone (ecdysone) activity by introducing EcR-USP cDNA and a bacterial lacZ reporter gene into yeast.	Ecdysone	96-104	Ecdysone receptor	Drosophila melanogaster	130-133
28680812-3	2017	In the present study, we developed reporter gene assay (RGA) systems to detect molting hormone (ecdysone) activity by introducing EcR-USP cDNA and a bacterial lacZ reporter gene into yeast.	Ecdysone	96-104	ultraspiracle	Drosophila melanogaster	134-137
28680812-7	2017	Furthermore, the insect order-selective ligand activities of synthetic nonsteroidal ecdysone agonists were linearly related to their binding activities, which were measured against in vitro translated EcR-USP complexes.	Ecdysone	84-92	Ecdysone receptor	Drosophila melanogaster	201-204
28680812-7	2017	Furthermore, the insect order-selective ligand activities of synthetic nonsteroidal ecdysone agonists were linearly related to their binding activities, which were measured against in vitro translated EcR-USP complexes.	Ecdysone	84-92	ultraspiracle	Drosophila melanogaster	205-208
28837687-2	2017	Previously, we found that the AAA chaperone Valosin-Containing Protein (VCP) regulates ecdysone-dependent dendrite pruning of Drosophila class IV dendritic arborization (c4da) neurons via an effect on RNA metabolism.	Ecdysone	87-95	TER94	Drosophila melanogaster	44-70
28837687-2	2017	Previously, we found that the AAA chaperone Valosin-Containing Protein (VCP) regulates ecdysone-dependent dendrite pruning of Drosophila class IV dendritic arborization (c4da) neurons via an effect on RNA metabolism.	Ecdysone	87-95	TER94	Drosophila melanogaster	72-75
28528906-5	2017	Here, we show that Warts (Wts; LATS1/2) signaling regulates systemic growth in Drosophila by activating basal ecdysone production, which negatively regulates body growth.	Ecdysone	110-118	warts	Drosophila melanogaster	31-38
28528906-6	2017	Further, we provide evidence that Wts mediates effects of insulin and the neuropeptide prothoracicotropic hormone (PTTH) on regulation of ecdysone production through Yorkie (Yki; YAP/TAZ) and the microRNA bantam (ban).	Ecdysone	138-146	warts	Drosophila melanogaster	34-37
28528906-6	2017	Further, we provide evidence that Wts mediates effects of insulin and the neuropeptide prothoracicotropic hormone (PTTH) on regulation of ecdysone production through Yorkie (Yki; YAP/TAZ) and the microRNA bantam (ban).	Ecdysone	138-146	insulin	Gallus gallus	58-65
28528906-6	2017	Further, we provide evidence that Wts mediates effects of insulin and the neuropeptide prothoracicotropic hormone (PTTH) on regulation of ecdysone production through Yorkie (Yki; YAP/TAZ) and the microRNA bantam (ban).	Ecdysone	138-146	tafazzin	Gallus gallus	183-186
28528906-7	2017	Thus, Wts couples insulin signaling with ecdysone production to adjust systemic growth in response to nutritional conditions during development.	Ecdysone	41-49	warts	Drosophila melanogaster	6-9
28528906-10	2017	Our data show that, in addition to its well-known intrinsic role in restricting organ growth, Wts/Yki/ban signaling also controls growth systemically by regulating ecdysone production, a mechanism that we propose controls growth between tissues and organismal size in response to nutrient availability.	Ecdysone	164-172	warts	Drosophila melanogaster	94-97
28126734-7	2017	Our data reveal that PVR is active in a dual-secured mechanism that involves an ecdysone-induced fat-body remodeling pathway and a reinforced PVR pathway for effective lipid mobilization.	Ecdysone	80-88	PDGF- and VEGF-receptor related	Drosophila melanogaster	21-24
28115695-8	2017	Conversely, interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increased production of winged offspring.	Ecdysone	29-37	ecdysone receptor	Acyrthosiphon pisum	57-74
28126483-1	2017	We previously reported regarding an ecdysone-inducible angiotensin-converting enzyme (ACE) gene.	Ecdysone	36-44	LOC101737600	Bombyx mori	55-84
28126483-1	2017	We previously reported regarding an ecdysone-inducible angiotensin-converting enzyme (ACE) gene.	Ecdysone	36-44	LOC101737600	Bombyx mori	86-89
28394252-5	2017	We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone.	Ecdysone	209-217	seven up	Drosophila melanogaster	13-21
28394252-5	2017	We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone.	Ecdysone	209-217	Chronologically inappropriate morphogenesis	Drosophila melanogaster	31-37
28394252-5	2017	We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone.	Ecdysone	209-217	IGF-II mRNA-binding protein	Drosophila melanogaster	38-41
28394252-5	2017	We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone.	Ecdysone	209-217	Syncrip	Drosophila melanogaster	45-52
28394252-5	2017	We show that Seven-up triggers Chinmo/Imp to Syncrip/Broad/E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering them competent to respond to the systemic hormone ecdysone.	Ecdysone	209-217	Ecdysone-induced protein 93F	Drosophila melanogaster	59-62
27855280-7	2017	Thus, our results demonstrated a new feedback regulation degradation (EO) pathway controlled by ecdysone itself through transcription factor E74A, expanding the knowledge about the regulatory system that determines the formation of ecdysone pulse.	Ecdysone	96-104	ecdysone oxidase	Bombyx mori	70-72
28536147-7	2017	Finally, we show that the ecdysone-induced transcription factor E93 controls temporal identity by directly regulating chromatin accessibility across the genome.	Ecdysone	26-34	Ecdysone-induced protein 93F	Drosophila melanogaster	64-67
27558136-3	2016	Growth coordination between regenerating and undamaged imaginal discs is dependent on Dilp8 activation of nitric oxide synthase (NOS) in the prothoracic gland (PG), which slows the growth of undamaged discs by limiting ecdysone synthesis.	Ecdysone	219-227	Insulin-like peptide 8	Drosophila melanogaster	86-91
27558136-3	2016	Growth coordination between regenerating and undamaged imaginal discs is dependent on Dilp8 activation of nitric oxide synthase (NOS) in the prothoracic gland (PG), which slows the growth of undamaged discs by limiting ecdysone synthesis.	Ecdysone	219-227	Nitric oxide synthase	Drosophila melanogaster	106-127
26250909-1	2016	The active form of the Drosophila steroid hormone ecdysone, 20-hydroxyecdysone (20E), binds the heterodimer EcR/USP nuclear receptor to regulate target genes that elicit proliferation, cell death and differentiation during insect development.	Ecdysone	50-58	Ecdysone receptor	Drosophila melanogaster	108-111
26408093-7	2015	The robust body size adjustment of the dGPAT4 mutant is likely achieved by corresponding changes in ecdysone and insulin signaling, which is also manifested by compromised food intake.	Ecdysone	100-108	Glycerol-3-phosphate acyltransferase 4	Drosophila melanogaster	39-45
26721418-0	2016	Drosophila 4EHP is essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis.	Ecdysone	103-111	eukaryotic translation initiation factor 4E homologous protein	Drosophila melanogaster	11-15
26721418-4	2016	In addition, we found that expressing RNAi that targets 4EHP specifically in the prothoracic gland disrupted ecdysone biosynthesis, causing a block of the transition from the larval to pupal stages.	Ecdysone	109-117	eukaryotic translation initiation factor 4E homologous protein	Drosophila melanogaster	56-60
26721418-7	2016	Taken together, these results uncover a novel essential function for 4EHP in regulating ecdysone biosynthesis.	Ecdysone	88-96	eukaryotic translation initiation factor 4E homologous protein	Drosophila melanogaster	69-73
26253172-8	2015	Moreover, RNA interference-mediated down-regulation of either Antp or POU-M2 during silkworm wandering not only decreased the ecdysone titer but also led to the failure of metamorphosis.	Ecdysone	126-134	silk gland factor 3	Bombyx mori	70-76
26698662-1	2015	In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone.	Ecdysone	160-168	prothoracicotropic hormone	Bombyx mori	54-58
26698662-1	2015	In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone.	Ecdysone	160-168	ret proto-oncogene	Homo sapiens	74-98
26698662-1	2015	In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone.	Ecdysone	160-168	ret proto-oncogene	Homo sapiens	100-103
26556600-0	2015	dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.	Ecdysone	58-66	TBP-associated factor 10	Drosophila melanogaster	0-6
26556600-0	2015	dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.	Ecdysone	58-66	TBP-associated factor 10b	Drosophila melanogaster	12-19
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	104-112	TBP-associated factor 10	Drosophila melanogaster	42-48
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	104-112	TBP-associated factor 10b	Drosophila melanogaster	49-56
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	104-112	TBP-associated factor 10	Drosophila melanogaster	130-136
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	104-112	TBP-associated factor 10b	Drosophila melanogaster	145-152
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	208-216	TBP-associated factor 10	Drosophila melanogaster	42-48
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	208-216	TBP-associated factor 10b	Drosophila melanogaster	49-56
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	208-216	TBP-associated factor 10	Drosophila melanogaster	130-136
26556600-8	2015	Importantly, the phenotype resulting from dTaf10+dTaf10b mutation could be rescued by ectopically added ecdysone, suggesting that dTAF10- and/or dTAF10b-containing complexes are involved in the expression of ecdysone biosynthetic genes.	Ecdysone	208-216	TBP-associated factor 10b	Drosophila melanogaster	145-152
26556600-9	2015	Indeed, in dTaf10+dTaf10b mutants, cytochrome genes, which regulate ecdysone synthesis in the ring gland, were underrepresented.	Ecdysone	68-76	TBP-associated factor 10	Drosophila melanogaster	11-17
26556600-9	2015	Indeed, in dTaf10+dTaf10b mutants, cytochrome genes, which regulate ecdysone synthesis in the ring gland, were underrepresented.	Ecdysone	68-76	TBP-associated factor 10b	Drosophila melanogaster	18-25
26441350-6	2015	These neurons are located in the pars intercerebralis, an important neuroendocrine area in the brain, and make physical contacts with the PTTH neurons that ultimately control the production and release of the molting steroid ecdysone.	Ecdysone	225-233	Prothoracicotropic hormone	Drosophila melanogaster	138-142
25959239-0	2015	Acetylations of Ftz-F1 and histone H4K5 are required for the fine-tuning of ecdysone biosynthesis during Drosophila metamorphosis.	Ecdysone	76-84	ftz transcription factor 1	Drosophila melanogaster	16-22
25654229-4	2015	Further examination demonstrated that ecdysone application in BmN4 cells not only changed the transcription of these two cell cycle genes like that under EcR overexpression, but also induced cell cycle arrest at G2/M phase.	Ecdysone	38-46	ecdysone receptor	Bombyx mori	154-157
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	ftz transcription factor 1	Drosophila melanogaster	82-117
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	ftz transcription factor 1	Drosophila melanogaster	119-129
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	Hormone receptor 3	Drosophila melanogaster	164-182
25747870-5	2015	As observed in Drosophila, NO signaling targets the nuclear hormone receptor beta fushi tarazu transcription factor 1 (betaFTZ-F1) through activation of Drosophila hormone receptor 3 (DHR3), two key regulators of ecdysone production and metamorphic tissue progression.	Ecdysone	213-221	Hormone receptor 3	Drosophila melanogaster	184-188
25605909-2	2015	Ecdysone production is regulated in the prothoracic gland (PG) by prothoracicotropic hormone (PTTH) and insulin-like peptides (Ilps).	Ecdysone	0-8	Prothoracicotropic hormone	Drosophila melanogaster	94-98
25605909-4	2015	PG-specific knockdown of a monoamine G protein-coupled receptor, beta3-octopamine receptor (Octbeta3R), resulted in arrested metamorphosis due to lack of ecdysone.	Ecdysone	154-162	Octopamine beta3 receptor	Drosophila melanogaster	92-101
25605909-7	2015	Thus, monoaminergic autocrine signaling in the PG regulates ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps.	Ecdysone	60-68	Prothoracicotropic hormone	Drosophila melanogaster	122-126
26330806-9	2015	We demonstrated that T-bet expression induced by ecdysone treatment in human embryonic kidney (HEK) cells increased IFN-gamma promoter activity in a dose dependent manner, and sustained T-bet expression considerably decreased cell proliferation in HEK cells.	Ecdysone	49-57	T-box transcription factor 21	Homo sapiens	21-26
26330806-9	2015	We demonstrated that T-bet expression induced by ecdysone treatment in human embryonic kidney (HEK) cells increased IFN-gamma promoter activity in a dose dependent manner, and sustained T-bet expression considerably decreased cell proliferation in HEK cells.	Ecdysone	49-57	interferon gamma	Homo sapiens	116-125
25979705-2	2015	In this report we show that CTCF expression in the prothoracic gland is required for full transcriptional activation of the Halloween genes spookier, shadow and noppera-bo, which encode ecdysone biosynthetic enzymes, and for proper timing of ecdysone-responsive gene expression.	Ecdysone	186-194	CTCF	Drosophila melanogaster	28-32
25624267-3	2015	Ecdysone-induced protein 78C (E78), a nuclear hormone receptor closely related to Drosophila E75 and to mammalian Rev-Erb and Peroxisome Proliferator Activated Receptors, was originally identified as an early ecdysone target; however, it has remained unclear whether E78 significantly contributes to adult physiology or reproductive function.	Ecdysone	209-217	Ecdysone-induced protein 78C	Drosophila melanogaster	0-28
25624267-3	2015	Ecdysone-induced protein 78C (E78), a nuclear hormone receptor closely related to Drosophila E75 and to mammalian Rev-Erb and Peroxisome Proliferator Activated Receptors, was originally identified as an early ecdysone target; however, it has remained unclear whether E78 significantly contributes to adult physiology or reproductive function.	Ecdysone	209-217	Ecdysone-induced protein 78C	Drosophila melanogaster	30-33
25624267-7	2015	Consistent with its initial discovery as an ecdysone-induced target, we also found significant genetic interactions between E78 and components of the ecdysone-signaling pathway.	Ecdysone	44-52	Ecdysone-induced protein 78C	Drosophila melanogaster	124-127
25624267-7	2015	Consistent with its initial discovery as an ecdysone-induced target, we also found significant genetic interactions between E78 and components of the ecdysone-signaling pathway.	Ecdysone	150-158	Ecdysone-induced protein 78C	Drosophila melanogaster	124-127
25654229-5	2015	In vivo analysis confirmed that E2F-1 expression was elevated in silk gland of silkworm larvae after ecdysone application, which is same as its response to ecdysone in BmN4 cells.	Ecdysone	101-109	E2F transcription factor 1	Bombyx mori	32-37
25403936-8	2015	Proteins copurified with EcR include factors involved in transcription, chromatin remodeling, ecdysone signaling, ecdysone biosynthesis, and other signaling pathways.	Ecdysone	94-102	Ecdysone receptor	Drosophila melanogaster	25-28
25403936-8	2015	Proteins copurified with EcR include factors involved in transcription, chromatin remodeling, ecdysone signaling, ecdysone biosynthesis, and other signaling pathways.	Ecdysone	114-122	Ecdysone receptor	Drosophila melanogaster	25-28
24393712-7	2014	Mutation of more than three putative EcREs, followed by introduction into the wing discs, abolished the activation of the BmE74B promoter by a low concentration of ecdysone.	Ecdysone	164-172	transcription factor E74	Bombyx mori	122-128
25344753-4	2014	We identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development, through post-translational control of the Shavenbaby transcription factor.	Ecdysone	96-104	Pri	Drosophila melanogaster	114-117
25309365-0	2014	The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect.	Ecdysone	78-86	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	28-34
25072638-0	2014	Pigment dispersing factor regulates ecdysone biosynthesis via bombyx neuropeptide G protein coupled receptor-B2 in the prothoracic glands of Bombyx mori.	Ecdysone	36-44	pigment-dispersing factor	Bombyx mori	0-25
25072638-4	2014	Here, we demonstrate that the neuropeptide pigment dispersing factor (PDF) stimulates ecdysone biosynthesis and that this novel signaling pathway partially overlaps with the prothoracicotropic hormone (PTTH) signaling pathway.	Ecdysone	86-94	pigment-dispersing factor	Bombyx mori	43-68
25072638-4	2014	Here, we demonstrate that the neuropeptide pigment dispersing factor (PDF) stimulates ecdysone biosynthesis and that this novel signaling pathway partially overlaps with the prothoracicotropic hormone (PTTH) signaling pathway.	Ecdysone	86-94	pigment-dispersing factor	Bombyx mori	70-73
25072638-9	2014	PDF stimulated ecdysone biosynthesis in the PGs, but the stimulation was only observed in the PGs during a specific larval stage.	Ecdysone	15-23	pigment-dispersing factor	Bombyx mori	0-3
24576019-5	2014	Sequence analyses and competition assays suggested that the protein(s) bound to EcRE-P might include components other than the ecdysone receptor (EcR), suggesting that BmBR-C transcription was indirectly activated by ecdysone through the EcRE-P.	Ecdysone	127-135	ecdysone receptor	Bombyx mori	80-83
24576019-5	2014	Sequence analyses and competition assays suggested that the protein(s) bound to EcRE-P might include components other than the ecdysone receptor (EcR), suggesting that BmBR-C transcription was indirectly activated by ecdysone through the EcRE-P.	Ecdysone	127-135	broad-complex	Bombyx mori	168-174
24845618-13	2014	Together, we propose a novel role for Drosophila Ceng1A in regulating ecdysone signaling-dependent second to third instar larval transition.	Ecdysone	70-78	Centaurin gamma 1A	Drosophila melanogaster	49-55
24550005-3	2014	This study investigated whether ecdysone-induced expression of receptor protein tyrosine phosphatase PTP52F regulates this process.	Ecdysone	32-40	Protein tyrosine phosphatase 52F	Drosophila melanogaster	101-107
24550005-9	2014	This study demonstrates a novel function of PTP52F in regulating ecdysone-directed metamorphosis via enhancement of autophagic and apoptotic cell death in doomed Drosophila midguts.	Ecdysone	65-73	Protein tyrosine phosphatase 52F	Drosophila melanogaster	44-50
24722212-7	2014	In the steroidogenic prothoracic gland, loss of Ecd or Prp8 prevents splicing of a large intron from CYP307A2/spookier (spok) pre-mRNA, thus eliminating this essential ecdysone-biosynthetic enzyme and blocking the entry to metamorphosis.	Ecdysone	168-176	ecdysoneless cell cycle regulator	Homo sapiens	48-51
24722212-7	2014	In the steroidogenic prothoracic gland, loss of Ecd or Prp8 prevents splicing of a large intron from CYP307A2/spookier (spok) pre-mRNA, thus eliminating this essential ecdysone-biosynthetic enzyme and blocking the entry to metamorphosis.	Ecdysone	168-176	pre-mRNA processing factor 8	Homo sapiens	55-59
24722212-9	2014	When expressed in the Ecd-deficient prothoracic gland, hEcd re-establishes spok pre-mRNA splicing and protein expression, restoring ecdysone synthesis and normal development.	Ecdysone	132-140	ecdysoneless cell cycle regulator	Homo sapiens	22-25
24722212-9	2014	When expressed in the Ecd-deficient prothoracic gland, hEcd re-establishes spok pre-mRNA splicing and protein expression, restoring ecdysone synthesis and normal development.	Ecdysone	132-140	ecdysoneless cell cycle regulator	Homo sapiens	55-59
25175165-3	2014	In this study, using dual-spike-in qPCR method, we examined the expression of Bombyx ultraspiracle gene (BmUSP) in various tissues of silkworm as well as expression changes after stimulation with ecdysone.	Ecdysone	196-204	protein ultraspiracle homolog	Bombyx mori	105-110
25175165-4	2014	The results showed that the expression levels of BmUSP gene varied in different tissues and were increased 2 h after exposure to ecdysone.	Ecdysone	129-137	protein ultraspiracle homolog	Bombyx mori	49-54
25421296-0	2014	Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis.	Ecdysone	69-77	forkhead box, sub-group O	Drosophila melanogaster	41-45
25421296-0	2014	Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis.	Ecdysone	69-77	ultraspiracle	Drosophila melanogaster	46-59
25421296-3	2014	Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight.	Ecdysone	160-168	Target of rapamycin	Drosophila melanogaster	82-101
25421296-3	2014	Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight.	Ecdysone	160-168	Target of rapamycin	Drosophila melanogaster	103-106
25421296-6	2014	While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting FoxO-Usp binding reduces these delays.	Ecdysone	44-52	forkhead box, sub-group O	Drosophila melanogaster	21-25
25421296-8	2014	Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to critical weight, ensuring that growth only stops once larvae have achieved a target nutritional status.	Ecdysone	25-33	forkhead box, sub-group O	Drosophila melanogaster	61-65
25421296-8	2014	Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to critical weight, ensuring that growth only stops once larvae have achieved a target nutritional status.	Ecdysone	25-33	ultraspiracle	Drosophila melanogaster	66-69
25313867-6	2014	Marf is required to form contacts between the endoplasmic reticulum and/or lipid droplets (LDs) and for proper storage of cholesterol and ecdysone synthesis in ring glands.	Ecdysone	138-146	mitofusin 2	Homo sapiens	0-4
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysone	22-30	Ecdysone receptor	Drosophila melanogaster	69-72
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysone	22-30	Ecdysone-induced protein 75B	Drosophila melanogaster	140-143
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysone	22-30	Hormone receptor 3	Drosophila melanogaster	145-149
25252945-4	2014	Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and betaFtz-f1, representing a model for steroid hormone signalling.	Ecdysone	22-30	ftz transcription factor 1	Drosophila melanogaster	154-164
25081570-11	2014	In testes and ovaries, alterations of the ecdysone-induced let-7 result in aberrant gonadal somatic cell behavior and non-cell-autonomous defects in early germline differentiation.	Ecdysone	42-50	let-7	Drosophila melanogaster	59-64
24963666-9	2014	We suggest a model in which these multiple oogenesis defects result from a misregulation of the ecdysone signaling network, through the fine-tuning of Abrupt and Fasciclin2 expression.	Ecdysone	96-104	Fasciclin 2	Drosophila melanogaster	162-172
24945490-9	2014	The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources.	Ecdysone	22-30	ventral vein lacking	Tribolium castaneum	95-98
24945490-9	2014	The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources.	Ecdysone	22-30	ventral vein lacking	Tribolium castaneum	184-187
24945490-9	2014	The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources.	Ecdysone	204-212	ventral vein lacking	Tribolium castaneum	95-98
24945490-9	2014	The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources.	Ecdysone	204-212	ventral vein lacking	Tribolium castaneum	184-187
24945799-7	2014	Vvl and Kni bind to PG specific cis-regulatory elements that are required for expression of the ecdysone biosynthetic genes.	Ecdysone	96-104	ventral veins lacking	Drosophila melanogaster	0-3
24945799-7	2014	Vvl and Kni bind to PG specific cis-regulatory elements that are required for expression of the ecdysone biosynthetic genes.	Ecdysone	96-104	knirps	Drosophila melanogaster	8-11
24945799-8	2014	Knock down of either vvl or kni in the PG results in a larval developmental arrest due to failure in ecdysone production.	Ecdysone	101-109	ventral veins lacking	Drosophila melanogaster	21-24
24945799-8	2014	Knock down of either vvl or kni in the PG results in a larval developmental arrest due to failure in ecdysone production.	Ecdysone	101-109	knirps	Drosophila melanogaster	28-31
24945799-9	2014	Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth.	Ecdysone	161-169	ventral veins lacking	Drosophila melanogaster	13-16
24945799-9	2014	Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth.	Ecdysone	161-169	knirps	Drosophila melanogaster	21-24
24945799-9	2014	Furthermore, Vvl and Kni are also required for maintenance of TOR/S6K and prothoracicotropic hormone (PTTH) signaling in the PG, two major pathways that control ecdysone biosynthesis and PG cell growth.	Ecdysone	161-169	Prothoracicotropic hormone	Drosophila melanogaster	102-106
24945799-11	2014	Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling.	Ecdysone	49-57	ventral veins lacking	Drosophila melanogaster	19-22
24945799-11	2014	Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling.	Ecdysone	49-57	knirps	Drosophila melanogaster	27-30
24945799-11	2014	Our data show that Vvl and Kni directly regulate ecdysone biosynthesis by transcriptional control of biosynthetic gene expression and indirectly by affecting PTTH and TOR/S6K signaling.	Ecdysone	49-57	Prothoracicotropic hormone	Drosophila melanogaster	158-162
24468295-6	2014	In ino80 mutant animals, inefficient repression of transcriptional responses to the late larval ecdysone pulse delays the onset of the subsequent prepupal ecdysone pulse, resulting in a significantly longer prepupal stage.	Ecdysone	96-104	INO80 complex subunit	Drosophila melanogaster	3-8
24393712-8	2014	The results confirmed the role of ecdysone response elements in the transcription regulation of BmE74B and demonstrated that multiple putative EcREs were involved in the maximum response of BmE74B to low concentrations of ecdysone.	Ecdysone	34-42	transcription factor E74	Bombyx mori	96-102
24393712-8	2014	The results confirmed the role of ecdysone response elements in the transcription regulation of BmE74B and demonstrated that multiple putative EcREs were involved in the maximum response of BmE74B to low concentrations of ecdysone.	Ecdysone	34-42	transcription factor E74	Bombyx mori	190-196
24393712-8	2014	The results confirmed the role of ecdysone response elements in the transcription regulation of BmE74B and demonstrated that multiple putative EcREs were involved in the maximum response of BmE74B to low concentrations of ecdysone.	Ecdysone	222-230	transcription factor E74	Bombyx mori	96-102
24393712-8	2014	The results confirmed the role of ecdysone response elements in the transcription regulation of BmE74B and demonstrated that multiple putative EcREs were involved in the maximum response of BmE74B to low concentrations of ecdysone.	Ecdysone	222-230	transcription factor E74	Bombyx mori	190-196
24247008-0	2014	Secretory competence in a gateway endocrine cell conferred by the nuclear receptor betaFTZ-F1 enables stage-specific ecdysone responses throughout development in Drosophila.	Ecdysone	117-125	ftz transcription factor 1	Drosophila melanogaster	83-93
24373956-0	2014	Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila.	Ecdysone	48-56	phantom	Drosophila melanogaster	0-7
24373956-3	2014	Here we find that mutations in phantom (phm), encoding an enzyme in the ecdysone biosynthesis pathway, block border cell migration when the entire follicular epithelium of an egg chamber is mutant, even when the associated germline cells (nurse cells and oocyte) are wild-type.	Ecdysone	72-80	phantom	Drosophila melanogaster	31-38
24373956-3	2014	Here we find that mutations in phantom (phm), encoding an enzyme in the ecdysone biosynthesis pathway, block border cell migration when the entire follicular epithelium of an egg chamber is mutant, even when the associated germline cells (nurse cells and oocyte) are wild-type.	Ecdysone	72-80	phantom	Drosophila melanogaster	40-43
23519136-5	2013	Here, we hypothesize that chromatin landscape changes induced by ecdysone surges direct the HDAC1- or HP1a-containing Fru complex to distinct targets, thereby allowing them to switch the neuronal sexual fate in the brain.	Ecdysone	65-73	Histone deacetylase 1	Drosophila melanogaster	92-97
24188886-5	2014	Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine.	Ecdysone	134-142	Octopamine receptor in mushroom bodies	Drosophila melanogaster	79-83
24188886-5	2014	Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine.	Ecdysone	134-142	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	85-91
24188886-5	2014	Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine.	Ecdysone	134-142	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	93-100
23727127-3	2013	EcR and its ligands are used in commercially available ecdysone-inducible expression systems and are considered to be artificial gene switches with potential therapeutic applications.	Ecdysone	55-63	Ecdysone receptor	Drosophila melanogaster	0-3
24086064-5	2013	This potential of Myc is harnessed by many different signaling pathways, involving, among others, Wg, Dpp, Hpo, ecdysone, insulin, and mTOR.	Ecdysone	112-120	Myc	Drosophila melanogaster	18-21
23637979-9	2013	Transient and stable expression of the domain I mutant U5-200kD protein using an ecdysone-inducible system and transient expression of an anti-U5-200kD short hairpin RNA (shRNA) resulted in differential splicing and growth defects in the 293/EcR cells.	Ecdysone	81-89	small nuclear ribonucleoprotein U5 subunit 200	Homo sapiens	55-63
24406335-4	2014	We found that CncC and dKeap1 control metamorphosis through regulations of ecdysone biosynthetic genes and ecdysone response genes in different tissues.	Ecdysone	75-83	cap-n-collar	Drosophila melanogaster	14-18
24406335-4	2014	We found that CncC and dKeap1 control metamorphosis through regulations of ecdysone biosynthetic genes and ecdysone response genes in different tissues.	Ecdysone	75-83	Keap1	Drosophila melanogaster	23-29
25143532-5	2014	We previously found that one of the Drosophila early genes, E75, harbors multiple functional ecdysone response elements (EcREs).	Ecdysone	93-101	Ecdysone-induced protein 75B	Drosophila melanogaster	60-63
23773803-10	2013	These effects are strongly enhanced by starvation and are accompanied by massive alterations of ecdysone production resulting most likely from increased Imp-L2 production by neurons directly contacting the PG and not from elevated Imp-L2 levels in the hemolymph.	Ecdysone	96-104	Ecdysone-inducible gene L2	Drosophila melanogaster	153-159
23773803-11	2013	Taken together our results suggest that Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions.	Ecdysone	154-162	Ecdysone-inducible gene L2	Drosophila melanogaster	40-46
23640098-5	2013	This work suggested that dopa decarboxylase is one set of the key enzymes in molting, which closely related with the regulation of ecdysone at the time of biological molting processes.	Ecdysone	131-139	aromatic-L-amino-acid decarboxylase	Bombyx mori	25-43
23519136-5	2013	Here, we hypothesize that chromatin landscape changes induced by ecdysone surges direct the HDAC1- or HP1a-containing Fru complex to distinct targets, thereby allowing them to switch the neuronal sexual fate in the brain.	Ecdysone	65-73	Suppressor of variegation 205	Drosophila melanogaster	102-106
23519136-5	2013	Here, we hypothesize that chromatin landscape changes induced by ecdysone surges direct the HDAC1- or HP1a-containing Fru complex to distinct targets, thereby allowing them to switch the neuronal sexual fate in the brain.	Ecdysone	65-73	fruitless	Drosophila melanogaster	118-121
23637637-2	2013	Silencing the Drosophila SUMO homologue smt3 in the prothoracic gland leads to reduced lipid content, low ecdysone titers, and a block in the larval-pupal transition.	Ecdysone	106-114	smt3	Drosophila melanogaster	25-29
23637637-2	2013	Silencing the Drosophila SUMO homologue smt3 in the prothoracic gland leads to reduced lipid content, low ecdysone titers, and a block in the larval-pupal transition.	Ecdysone	106-114	smt3	Drosophila melanogaster	40-44
23069846-3	2013	BHR3 showed different ecdysone responsiveness from other ecdysone-responsive transcription factors (ERTFs) and was induced by ecdysone addition but showed decrease by ecdysone removal after treatment (ecdysone pulse).	Ecdysone	22-30	hormone receptor 3	Bombyx mori	0-4
23197473-4	2013	We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdysone-responsive genes.	Ecdysone	110-118	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	13-17
23069846-3	2013	BHR3 showed different ecdysone responsiveness from other ecdysone-responsive transcription factors (ERTFs) and was induced by ecdysone addition but showed decrease by ecdysone removal after treatment (ecdysone pulse).	Ecdysone	57-65	hormone receptor 3	Bombyx mori	0-4
23069846-3	2013	BHR3 showed different ecdysone responsiveness from other ecdysone-responsive transcription factors (ERTFs) and was induced by ecdysone addition but showed decrease by ecdysone removal after treatment (ecdysone pulse).	Ecdysone	57-65	hormone receptor 3	Bombyx mori	0-4
23069846-3	2013	BHR3 showed different ecdysone responsiveness from other ecdysone-responsive transcription factors (ERTFs) and was induced by ecdysone addition but showed decrease by ecdysone removal after treatment (ecdysone pulse).	Ecdysone	57-65	hormone receptor 3	Bombyx mori	0-4
23347515-6	2013	PTTH stimulates ecdysone production through a Ras/Raf/ERK signaling cascade; however, comparatively little is known about the downstream targets of this pathway.	Ecdysone	16-24	Prothoracicotropic hormone	Drosophila melanogaster	0-4
23347515-6	2013	PTTH stimulates ecdysone production through a Ras/Raf/ERK signaling cascade; however, comparatively little is known about the downstream targets of this pathway.	Ecdysone	16-24	Raf oncogene	Drosophila melanogaster	50-53
23408904-7	2013	CncC and dKeap1 depletion in the prothoracic gland as well as cncC(K6/K6) and dKeap1(EY5/EY5) loss of function mutations in embryos reduced ecdysone-biosynthetic gene transcription.	Ecdysone	140-148	Keap1	Drosophila melanogaster	78-84
24385925-3	2013	Later during metamorphosis, ecdysone signaling induces a cell fate and sensory receptor switch: Rh5-PRs are re-programmed to express Rh6 and become the eyelet, a small group of extraretinal PRs involved in circadian entrainment.	Ecdysone	28-36	Rhodopsin 5	Drosophila melanogaster	96-99
23347515-6	2013	PTTH stimulates ecdysone production through a Ras/Raf/ERK signaling cascade; however, comparatively little is known about the downstream targets of this pathway.	Ecdysone	16-24	rolled	Drosophila melanogaster	54-57
22422652-8	2012	Fhos is differentially transcribed during development and responds to ecdysone in a method that is similar to other cell death genes.	Ecdysone	70-78	Formin homology 2 domain containing	Drosophila melanogaster	0-4
24130506-7	2013	A memory defect caused by suppressing dopamine synthesis was also restored through enhanced DopEcR-mediated ecdysone signaling, and rescue and phenocopy experiments revealed that the mushroom body (MB)--a brain region central to learning and memory in Drosophila--is critical for the DopEcR-dependent processing of courtship memory.	Ecdysone	108-116	Dopamine/Ecdysteroid receptor	Drosophila melanogaster	92-98
22508764-2	2012	Here, we show that the JIL-1 kinase is present at both enhancers and promoters of ecdysone-induced Drosophila genes, where it phosphorylates the Ser10 and Ser28 residues of histone H3.	Ecdysone	82-90	JIL-1 kinase	Drosophila melanogaster	23-35
22828514-8	2012	It may suggest that the heterodimeric complex EcR/USP mediates the activation of ecdysone-dependent BmCatD transcription in the larval fat body of B. mori.	Ecdysone	81-89	ecdysone receptor	Bombyx mori	46-49
22828514-8	2012	It may suggest that the heterodimeric complex EcR/USP mediates the activation of ecdysone-dependent BmCatD transcription in the larval fat body of B. mori.	Ecdysone	81-89	cathepsin D	Bombyx mori	100-106
22729648-3	2012	EcR-293 cells (which endogenously produce Cx43) were transfected with ecdysone-inducible plasmids encoding Cx37 or Cx40.	Ecdysone	70-78	gap junction protein alpha 4	Homo sapiens	107-111
22729648-3	2012	EcR-293 cells (which endogenously produce Cx43) were transfected with ecdysone-inducible plasmids encoding Cx37 or Cx40.	Ecdysone	70-78	gap junction protein alpha 5	Homo sapiens	115-119
22556250-4	2012	DILP8 delays metamorphosis by inhibiting ecdysone biosynthesis, slowing growth in the imaginal discs, and generating normal-sized animals.	Ecdysone	41-49	Insulin-like peptide 8	Drosophila melanogaster	0-5
22654869-4	2012	Furthermore, they have shown that the insulin/TOR pathway interacts with hormonal systems, like ecdysone and juvenile hormone, to regulate the timing of development and hence the duration of growth.	Ecdysone	96-104	Insulin-like receptor	Drosophila melanogaster	38-45
22559968-1	2012	The insect brain secretes prothoracicotropic hormone (PTTH), which stimulates the prothoracic gland to synthesize ecdysone.	Ecdysone	114-122	prothoracicotropic hormone	Bombyx mori	54-58
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysone	25-33	ecdysone receptor	Bombyx mori	75-92
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysone	25-33	ecdysone receptor	Bombyx mori	94-97
22559968-2	2012	The active metabolite of ecdysone, 20-hydroxyecdysone (20E), works through ecdysone receptor (EcR) and ultraspiracle (USP) to initiate molting and metamorphosis by regulating downstream genes.	Ecdysone	25-33	protein ultraspiracle homolog	Bombyx mori	118-121
22654869-4	2012	Furthermore, they have shown that the insulin/TOR pathway interacts with hormonal systems, like ecdysone and juvenile hormone, to regulate the timing of development and hence the duration of growth.	Ecdysone	96-104	Target of rapamycin	Drosophila melanogaster	46-49
23209440-4	2012	We demonstrate that belle directly regulates translation of E74A, an ets transcription factor and critical component of the ecdysone-induced transcriptional cascade.	Ecdysone	124-132	Ecdysone-induced protein 74EF	Drosophila melanogaster	60-64
23226617-3	2012	Here, we show that DREF mutant females have steroid hormone ecdysone-deficient phenotypes, such as the loss of vitellogenic egg chambers.	Ecdysone	60-68	DNA replication-related element factor	Drosophila melanogaster	19-23
22194697-5	2011	Rather, the use of UAS-RpS6 RNAi transgenics revealed that the suppression of cycE(JP) is exerted via a mechanism extrinsic to the eye, whereby reduced Rp levels in the prothoracic gland decreases the activity of ecdysone, the steroid hormone, delaying developmental timing and hence allowing time for tissue and organ overgrowth.	Ecdysone	213-221	Cyclin E	Drosophila melanogaster	78-82
22808194-2	2012	To assess the contribution of different histone modifications to transcriptional activation in vivo, we determined the acetylation patterns on the ecdysone induced Eip74EF and Eip75B genes in Drosophila melanogaster larvae by chromatin immunoprecipitation.	Ecdysone	147-155	Ecdysone-induced protein 74EF	Drosophila melanogaster	164-171
22808194-2	2012	To assess the contribution of different histone modifications to transcriptional activation in vivo, we determined the acetylation patterns on the ecdysone induced Eip74EF and Eip75B genes in Drosophila melanogaster larvae by chromatin immunoprecipitation.	Ecdysone	147-155	Ecdysone-induced protein 75B	Drosophila melanogaster	176-182
20824293-3	2011	To understand the basis of this selective cytotoxicity, we constructed a fully functional ecdysone-inducible GFP-OGT.	Ecdysone	90-98	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	113-116
21982371-7	2011	EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at the sox14 locus.	Ecdysone	46-54	Ecdysone receptor	Drosophila melanogaster	0-6
21982371-7	2011	EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at the sox14 locus.	Ecdysone	46-54	nejire	Drosophila melanogaster	23-26
21982371-7	2011	EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at the sox14 locus.	Ecdysone	46-54	brahma	Drosophila melanogaster	80-83
21982371-7	2011	EcR-B1 associates with CBP in the presence of ecdysone, which is facilitated by Brm, resulting in local enrichment of an active chromatin mark H3K27Ac at the sox14 locus.	Ecdysone	46-54	Sox box protein 14	Drosophila melanogaster	158-163
21980261-2	2011	The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone).	Ecdysone	29-37	Prothoracicotropic hormone	Drosophila melanogaster	82-86
21980261-2	2011	The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone).	Ecdysone	29-37	Prothoracicotropic hormone	Drosophila melanogaster	88-113
21980261-9	2011	In contrast, reducing DHR4 function in the PG triggers accelerated development, which is caused by precocious ecdysone signaling due to a failure to repress ecdysone pulses.	Ecdysone	110-118	Hormone receptor 4	Drosophila melanogaster	22-26
21980261-11	2011	Disruption of Cyp6t3 function causes low ecdysteroid titers and results in heterochronic phenotypes and molting defects, indicating a novel role in the ecdysone biosynthesis pathway.	Ecdysone	152-160	Cyp6t3	Drosophila melanogaster	14-20
21980261-12	2011	We propose a model whereby nuclear DHR4 controls the duration of ecdysone pulses by negatively regulating ecdysone biosynthesis through repression of Cyp6t3, and that this repressive function is temporarily overturned via the PTTH pathway by removing DHR4 from the nuclear compartment.	Ecdysone	65-73	Hormone receptor 4	Drosophila melanogaster	35-39
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	248-256	cytochrome P450 306a1	Apis mellifera	188-196
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	248-256	cytochrome P450 302a1, mitochondrial	Apis mellifera	201-209
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	248-256	cytochrome P450 314A1	Apis mellifera	317-325
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	359-367	cytochrome P450 306a1	Apis mellifera	188-196
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	359-367	cytochrome P450 302a1, mitochondrial	Apis mellifera	201-209
21277979-2	2011	We show here that the expression of neverland and Non-molting glossy/shroud, which are involved in early steps of ecdysteroid synthesis, was enhanced in the ovary, while the expression of CYP306A1 and CYP302A1, which are involved in later steps of ecdysone synthesis, was enhanced in the brain, and the expression of CYP314A1, which is involved in converting ecdysone into active 20-hydroxyecdysone (20E), was enhanced in the brain, fat body, and ovary.	Ecdysone	359-367	cytochrome P450 314A1	Apis mellifera	317-325
21613324-4	2011	We further demonstrate that activin signaling regulates competence of the prothoracic gland to receive PTTH and insulin signals, and that these two pathways act at the mRNA and post-transcriptional levels, respectively, to control ecdysone biosynthetic enzyme expression.	Ecdysone	231-239	Activin-beta	Drosophila melanogaster	28-35
21215267-6	2011	Interestingly, we found that ecdysone, the steroid hormone responsible for the larval lethal phenotype in npc1 mutants, is not required for individualization.	Ecdysone	29-37	Niemann-Pick type C-1a	Drosophila melanogaster	106-110
20888228-0	2010	dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.	Ecdysone	81-89	deep orange	Drosophila melanogaster	0-4
21637834-6	2011	One of the temporally regulated genes, cyp18a1, which encodes a cytochromome P450 protein mediating ecdysone turnover, is downregulated in pxt mutant follicles, and cyp18a1 mutation itself alters eggshell gene expression.	Ecdysone	100-108	Cytochrome P450-18a1	Drosophila melanogaster	39-46
21125567-1	2011	Ecdysone was inactivated to 3-dehydroecdysone (3DE) under ecdysone oxidase (EO), and followed by NAD(P)H-dependent irreversible reduction to 3-epiecdysteroid under 3DE 3a-reductase.	Ecdysone	0-8	ecdysone oxidase	Bombyx mori	58-74
20672340-4	2010	However, for the discovery of ecdysone agonists that target other important insect groups such as Diptera, efficient screening systems that are based on the activation of the EcR are needed.	Ecdysone	30-38	ecdysone receptor	Bombyx mori	175-178
20888228-10	2010	Furthermore, because ecdysone signaling inhibits insulin signaling in the fat body, this also uncovers a feed-forward mechanism whereby ecdysone potentiates its own signaling via dDOR.	Ecdysone	21-29	insulin	Homo sapiens	49-56
20971430-1	2010	DOR, a nuclear receptor co-activator conserved from flies to humans, provides a molecular connection between ecdysone and insulin signaling, two important pathways controlling developmental timing and growth, respectively.	Ecdysone	109-117	tumor protein p53 inducible nuclear protein 2	Homo sapiens	0-3
20888228-10	2010	Furthermore, because ecdysone signaling inhibits insulin signaling in the fat body, this also uncovers a feed-forward mechanism whereby ecdysone potentiates its own signaling via dDOR.	Ecdysone	21-29	deep orange	Drosophila melanogaster	179-183
20888228-10	2010	Furthermore, because ecdysone signaling inhibits insulin signaling in the fat body, this also uncovers a feed-forward mechanism whereby ecdysone potentiates its own signaling via dDOR.	Ecdysone	136-144	insulin	Homo sapiens	49-56
20888228-10	2010	Furthermore, because ecdysone signaling inhibits insulin signaling in the fat body, this also uncovers a feed-forward mechanism whereby ecdysone potentiates its own signaling via dDOR.	Ecdysone	136-144	deep orange	Drosophila melanogaster	179-183
20399856-3	2010	Induction of the BMWCP10 transcript by ecdysone was partly inhibited in the presence of cycloheximide, which implies that the BMWCP10 promoter is directly and indirectly activated by ecdysone.	Ecdysone	39-47	cuticular protein RR-1 motif 21	Bombyx mori	17-24
20705711-9	2010	In addition, ecdysone-induced overexpression of HO-1 in cells led to a delay in autophagy progression, generated significantly lower levels of reactive oxygen species, and protected against cisplatin cytotoxicity.	Ecdysone	13-21	heme oxygenase 1	Mus musculus	48-52
20584983-6	2010	Mutants of dAda2b, a subunit of the dSAGA histone acetyltransferase complex, do not share phenotype characteristics and RNA profile alterations with dAda2a mutants, indicating that the ecdysone biosynthesis genes are regulated by dATAC, but not by dSAGA.	Ecdysone	185-193	transcriptional Adaptor 2b	Drosophila melanogaster	11-17
20621708-5	2010	npc1 is important for sterol trafficking in the ring gland during ecdysone biosynthesis.	Ecdysone	66-74	Niemann-Pick type C-1a	Drosophila melanogaster	0-4
20627082-0	2010	The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells.	Ecdysone	20-28	Myc	Drosophila melanogaster	68-72
20399856-3	2010	Induction of the BMWCP10 transcript by ecdysone was partly inhibited in the presence of cycloheximide, which implies that the BMWCP10 promoter is directly and indirectly activated by ecdysone.	Ecdysone	39-47	cuticular protein RR-1 motif 21	Bombyx mori	126-133
20399856-3	2010	Induction of the BMWCP10 transcript by ecdysone was partly inhibited in the presence of cycloheximide, which implies that the BMWCP10 promoter is directly and indirectly activated by ecdysone.	Ecdysone	183-191	cuticular protein RR-1 motif 21	Bombyx mori	17-24
20399856-3	2010	Induction of the BMWCP10 transcript by ecdysone was partly inhibited in the presence of cycloheximide, which implies that the BMWCP10 promoter is directly and indirectly activated by ecdysone.	Ecdysone	183-191	cuticular protein RR-1 motif 21	Bombyx mori	126-133
20082306-2	2010	To determine the effect of PKD1 overexpression on these biological responses, we generated inducible stable PANC-1 clones that express wild-type (WT) or kinase-dead (K618N) forms of PKD1 in response to the ecdysone analog ponasterone-A (PonA).	Ecdysone	206-214	protein kinase D1	Homo sapiens	182-186
21331299-4	2010	In this study we found that GSPE treatment significantly inhibits polyQ aggregation in phaeochromocytoma (PC)-12 cell line containing an ecdysone-inducible protein comprising the first 17 amino acid of huntingtin plus 103 glutamines fused with enhanced GFP.	Ecdysone	137-145	huntingtin	Mus musculus	202-212
20040570-3	2010	By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK (dDEK) was genetically identified as a coactivator of EcR in both insect cells and intact flies.	Ecdysone	33-41	Ecdysone receptor	Drosophila melanogaster	52-55
20069627-7	2010	CONCLUSION: The present study demonstrated that species-specific ecdysone-agonist-based insecticides can be developed, but their species specificity is not based on differences in the activation of the ecdysone receptor but rather on unidentified in vivo parameters such as permeability of the cuticle, uptake/excretion by the gut or metabolic detoxification.	Ecdysone	65-73	ecdysone receptor	Bombyx mori	202-219
20231890-4	2010	In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor) and USP (Ultraspiracle).	Ecdysone	12-20	Uncharacterized protein	Brugia malayi	68-85
20231890-4	2010	In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor) and USP (Ultraspiracle).	Ecdysone	12-20	Uncharacterized protein	Brugia malayi	104-107
20231890-4	2010	In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor) and USP (Ultraspiracle).	Ecdysone	12-20	Uncharacterized protein	Brugia malayi	109-126
20231890-6	2010	Bma-EcR dimerizes with insect and nematode USP/RXRs and binds to DNA encoding a canonical ecdysone response element (EcRE).	Ecdysone	90-98	Uncharacterized protein	Brugia malayi	4-7
20231890-8	2010	The Bma-EcR ligand-binding domain (LBD) exhibits ligand-dependent transactivation via a GAL4 fusion protein combined with a chimeric RXR in mammalian cells treated with Ponasterone-A or a synthetic ecdysone agonist.	Ecdysone	198-206	Uncharacterized protein	Brugia malayi	8-11
20170488-13	2010	Selected amino acid substitutions in Frq1 likely contributed to the functional divergence between the two duplicates, which, in turn, should have diverged in their regulation by ecdysone-induced early genes.	Ecdysone	178-186	Frequenin 1	Drosophila melanogaster	37-41
20133729-2	2010	Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes.	Ecdysone	23-31	spleen associated tyrosine kinase	Homo sapiens	13-16
20133729-2	2010	Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes.	Ecdysone	23-31	signal transducer and activator of transcription 3	Homo sapiens	81-86
20133729-2	2010	Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes.	Ecdysone	23-31	signal transducer and activator of transcription 3	Homo sapiens	170-175
20133729-2	2010	Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes.	Ecdysone	23-31	signal transducer and activator of transcription 3	Homo sapiens	170-175
20040570-3	2010	By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK (dDEK) was genetically identified as a coactivator of EcR in both insect cells and intact flies.	Ecdysone	33-41	Dek	Drosophila melanogaster	120-123
20040570-3	2010	By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK (dDEK) was genetically identified as a coactivator of EcR in both insect cells and intact flies.	Ecdysone	33-41	Dek	Drosophila melanogaster	125-129
20040570-3	2010	By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK (dDEK) was genetically identified as a coactivator of EcR in both insect cells and intact flies.	Ecdysone	33-41	Ecdysone receptor	Drosophila melanogaster	178-181
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	Ecdysone receptor	Drosophila melanogaster	249-252
20059956-5	2009	Expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone.	Ecdysone	82-90	Insulin-like peptide 6	Drosophila melanogaster	14-19
19847923-12	2009	Treatment with taxol resulted in accumulation of EcR in the cytoplasm and simultaneous depletion of EcR from the nucleus, suggesting that microtubules may be involved in targeted intracellular transport of EcR to the nucleus (genomic action) or may play a role in rapid ecdysone signal transduction in the extranuclear compartment, i.e., in non-genomic actions of ecdysone.	Ecdysone	270-278	Ecdysone receptor	Drosophila melanogaster	49-52
19513589-8	2009	When stimulated with ecdysone analogs, selenoprotein P expression was increased with the use of a fusion transcription factor that contains the glucocorticoid receptor DNA binding domain, an ecdysone ligand-binding domain, and a strong transactivation domain as well as the retinoid X receptor.	Ecdysone	21-29	selenoprotein P	Homo sapiens	39-54
19513589-8	2009	When stimulated with ecdysone analogs, selenoprotein P expression was increased with the use of a fusion transcription factor that contains the glucocorticoid receptor DNA binding domain, an ecdysone ligand-binding domain, and a strong transactivation domain as well as the retinoid X receptor.	Ecdysone	21-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	144-167
19513589-8	2009	When stimulated with ecdysone analogs, selenoprotein P expression was increased with the use of a fusion transcription factor that contains the glucocorticoid receptor DNA binding domain, an ecdysone ligand-binding domain, and a strong transactivation domain as well as the retinoid X receptor.	Ecdysone	21-29	retinoid X receptor alpha	Homo sapiens	274-293
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	Ecdysone receptor	Drosophila melanogaster	173-190
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	Ecdysone receptor	Drosophila melanogaster	231-234
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	Ecdysone receptor	Drosophila melanogaster	249-254
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	Ecdysone receptor	Drosophila melanogaster	256-262
19646872-3	2009	During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptors EcR (isoforms are EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).	Ecdysone	141-149	ultraspiracle	Drosophila melanogaster	294-297
19214204-7	2009	The TUNEL assay revealed an additional two genes (Kap-alpha3 and Smr) with an ecdysone-dependent cell survival function that was associated with reduced cell death.	Ecdysone	78-86	karyopherin alpha3	Drosophila melanogaster	50-60
19389369-4	2009	Specifically blocking the function of the different Ecdysone receptor (EcR) isoforms we demonstrate that EcR-B1 is responsible for ecdysone-mediated VM32E transcriptional regulation.	Ecdysone	131-139	Ecdysone receptor	Drosophila melanogaster	52-69
19389369-4	2009	Specifically blocking the function of the different Ecdysone receptor (EcR) isoforms we demonstrate that EcR-B1 is responsible for ecdysone-mediated VM32E transcriptional regulation.	Ecdysone	131-139	Ecdysone receptor	Drosophila melanogaster	71-74
19389369-4	2009	Specifically blocking the function of the different Ecdysone receptor (EcR) isoforms we demonstrate that EcR-B1 is responsible for ecdysone-mediated VM32E transcriptional regulation.	Ecdysone	131-139	Ecdysone receptor	Drosophila melanogaster	105-111
19389369-4	2009	Specifically blocking the function of the different Ecdysone receptor (EcR) isoforms we demonstrate that EcR-B1 is responsible for ecdysone-mediated VM32E transcriptional regulation.	Ecdysone	131-139	Vitelline membrane 32E	Drosophila melanogaster	149-154
19214204-7	2009	The TUNEL assay revealed an additional two genes (Kap-alpha3 and Smr) with an ecdysone-dependent cell survival function that was associated with reduced cell death.	Ecdysone	78-86	Smrter	Drosophila melanogaster	65-68
19214204-8	2009	In vitro, Sox14 RNAi reduced the percentage of TUNEL-positive l(2)mbn cells (p<0.05) following ecdysone treatment, and Sox14 overexpression was sufficient to induce apoptosis.	Ecdysone	98-106	Sox box protein 14	Drosophila melanogaster	10-15
19214204-9	2009	In vivo analyses of Sox14-RNAi animals revealed multiple phenotypes characteristic of aberrant or reduced ecdysone signaling, including defects in larval midgut and salivary gland destruction.	Ecdysone	106-114	Sox box protein 14	Drosophila melanogaster	20-25
18854141-3	2008	When activity of the Target of Rapamycin (TOR), a core component of the nutrient-responsive pathway, is reduced in the PG, the ecdysone peak that marks the end of larval development is abrogated.	Ecdysone	127-135	Target of rapamycin	Drosophila melanogaster	21-40
18854141-3	2008	When activity of the Target of Rapamycin (TOR), a core component of the nutrient-responsive pathway, is reduced in the PG, the ecdysone peak that marks the end of larval development is abrogated.	Ecdysone	127-135	Target of rapamycin	Drosophila melanogaster	42-45
18854141-7	2008	In conclusion, the PG uses TOR signaling to couple nutritional input with ecdysone production and developmental timing.	Ecdysone	74-82	Target of rapamycin	Drosophila melanogaster	27-30