PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23208961-4	2012	MATERIALS AND METHODS: Established recombinant plasmids of GR gene by combination use RNAi and the Cre-LoxP system, stably transfected the recombinant plasmids and Cre-ERT2 plasmid into the murine macrophage RAW264.7 cells and selected with G418 and hygromycin B respectively, then used 4-TH to induce Cre-ERT2 plasmid to express.	Hygromycin B	250-262	nuclear receptor subfamily 3, group C, member 1	Mus musculus	59-61
24257609-4	2014	Expression of a BEFV alpha1-maltose binding protein (MBP) fusion protein in Escherichia coli was observed to inhibit cell growth and increase membrane permeability to hygromycin B.	Hygromycin B	167-179	adrenoceptor alpha 1D	Homo sapiens	21-27
23240720-11	2013	Here, we show also that Vpu confers tolerance to the aminoglycoside antibiotic hygromycin B in Deltatrk1,2 yeast.	Hygromycin B	79-91	Vpu	Human immunodeficiency virus 1	24-27
22416758-5	2012	When mpg1 is depleted, the lack of mpg2 causes a synthetic enhancement of the growth defect, the sensitivity to hygromycin B and the cell cycle phenotype previously reported for mpg1 mutant.	Hygromycin B	112-124	mannose-1-phosphate guanylyltransferase	Saccharomyces cerevisiae S288C	5-9
22492205-4	2012	The deletion of OST3 in the rot1-1 mutant causes a temperature sensitive phenotype as well as sensitivity toward compounds interfering with cell wall biogenesis such as Calcofluor White, caffeine, Congo Red and hygromycin B, whereas the deletion of OST6, a functional homolog of OST3, has no effect.	Hygromycin B	211-223	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Saccharomyces cerevisiae S288C	16-20
21822730-9	2012	Moreover, eEF2 suppression of the eIF5A(K56A) mutant is correlated with the improvement of total protein synthesis and with the increased resistance to the protein synthesis inhibitor hygromycin B.	Hygromycin B	184-196	eukaryotic translation elongation factor 2	Homo sapiens	10-14
22268595-6	2012	The depolarization of ROF2 over-expressing plants explains their tolerance to toxic cations such as lithium, norspermidine and hygromycin B, whose uptake is driven by the membrane potential.	Hygromycin B	127-139	FKBP-type peptidyl-prolyl cis-trans isomerase family protein	Arabidopsis thaliana	22-26
22429578-4	2012	METHODS: The optimal concentration of hygromycin B for screening A549/nm23-H1-shRNA cells was determined by concentration gradient method.	Hygromycin B	38-50	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	70-77
22429578-8	2012	RESULTS: The optimal concentration of hygromycin B used in screening A549/nm23-H1-shRNA cells was 300 mug/mL.	Hygromycin B	38-50	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	74-81
22188384-5	2012	Phenotype manifestations of ypt6 deletion were usually more prominent than those of arl1 (cells were more sensitive to KCl, NaCl, LiCl, hygromycin B, increased temperature, and increased pH).	Hygromycin B	136-148	Rab family GTPase YPT6	Saccharomyces cerevisiae S288C	28-32
22188384-5	2012	Phenotype manifestations of ypt6 deletion were usually more prominent than those of arl1 (cells were more sensitive to KCl, NaCl, LiCl, hygromycin B, increased temperature, and increased pH).	Hygromycin B	136-148	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	84-88
22576669-4	2012	Initially, deletion constructs of the Sc and Sb types of URA3 were constructed in laboratory yeast strains in which a TDH3p-hygro allele conferring hygromycin B resistance replaced ScURA3 and a KanMX cassette conferring G-418 resistance replaced SbURA3.	Hygromycin B	148-160	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	57-61
21822730-9	2012	Moreover, eEF2 suppression of the eIF5A(K56A) mutant is correlated with the improvement of total protein synthesis and with the increased resistance to the protein synthesis inhibitor hygromycin B.	Hygromycin B	184-196	eukaryotic translation initiation factor 5A	Homo sapiens	34-39
21424545-6	2011	In addition, the deletion of TRK2 in the trk1 genetic background increased the cell sensitivity to hygromycin B, spermine, and TMA.	Hygromycin B	99-111	Trk2p	Saccharomyces cerevisiae S288C	29-33
21424545-6	2011	In addition, the deletion of TRK2 in the trk1 genetic background increased the cell sensitivity to hygromycin B, spermine, and TMA.	Hygromycin B	99-111	Trk1p	Saccharomyces cerevisiae S288C	41-45
22140429-7	2011	Surprisingly, co-expression of SYT2 and HYG(R) caused hypersensitivity of the transgenic Arabidopsis plants to hygromycin B.	Hygromycin B	111-123	Calcium-dependent lipid-binding (CaLB domain) family protein	Arabidopsis thaliana	31-35
19666721-3	2009	In this study, we show that yeast lacking Stm1p (stm1Delta) are hypersensitive to the translation inhibitor anisomycin, which affects the peptidyl transferase reaction in translation elongation, but show little hypersensitivity to other translation inhibitors such as paromomycin and hygromycin B, which affect translation fidelity.	Hygromycin B	284-296	Stm1p	Saccharomyces cerevisiae S288C	42-47
20087596-4	2010	We show that the rpt2a-3, rpn10-1 and rpn12a-1 mutants are hypersensitive to the antibiotic hygromycin B, and tolerant to the translation inhibitor cycloheximide (CHX) and herbicide L-phosphinothricin (PPT).	Hygromycin B	92-104	Phototropic-responsive NPH3 family protein	Arabidopsis thaliana	17-24
18843045-8	2008	In agreement, conditional cbk1 mutants mislocalize the cis-Golgi mannosyltransferase Och1, are hypersensitive to the aminoglycoside hygromycin B, and exhibit diminished invertase and Sim1 glycosylation.	Hygromycin B	132-144	serine/threonine protein kinase CBK1	Saccharomyces cerevisiae S288C	26-30
18843045-9	2008	Significantly, the conditional lethality and hygromycin B sensitivity of cbk1 mutants are suppressed by moderate overexpression of several Golgi mannosyltransferases.	Hygromycin B	45-57	serine/threonine protein kinase CBK1	Saccharomyces cerevisiae S288C	73-77
19003177-2	2008	Stably transformed polyclonal cell populations expressing RAI were isolated after 4 weeks of selection with hygromycin B.	Hygromycin B	108-120	ribonuclease/angiogenin inhibitor 1	Homo sapiens	58-61
16233801-4	2005	The mcd 4 mutant showed abnormal morphology and cell aggregation, and was hypersensitive to SDS, hygromycin B and K1 killer toxin.	Hygromycin B	97-109	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	4-9
16879429-5	2006	The overexpression of the Na+,K+/H+ antiporter Nha1 resulted in the hyperpolarization of the plasma membrane and consequently increased the sensitivity to Cs+, Tl+ and hygromycin B.	Hygromycin B	168-180	Nha1p	Saccharomyces cerevisiae S288C	47-51
16126896-3	2005	Here, we report that inhibition of hygromycin-B-induced apoptosis in HeLa cells depends on Z-DNA binding of the E3L Z alpha domain.	Hygromycin B	35-47	double-strand RNA-binding protein	Vaccinia virus	112-115
17343785-4	2007	After selection with hygromycin B for one month, transient and stable expression of EpoR/LR-F3/HAb18GEF were detected by indirect immunofluorescence staining, flow cytometry assay, and Zeocin test.	Hygromycin B	21-33	erythropoietin receptor	Homo sapiens	84-88
17059762-7	2006	Lipofectamine 2000 transfection and hygromycin B screening were used to establish PTEN-/- MEF241 cell line which could stably express silenced Ptn.	Hygromycin B	36-48	phosphatase and tensin homolog	Mus musculus	82-86
16597626-3	2006	Mutants resistant to hygromycin B during the growth of calli generated from non-green roots on callus-inducing medium resulted from the expression of hygromycin B phosphotransferase driven by the RBCS-3B promoter.	Hygromycin B	21-33	Ribulose bisphosphate carboxylase (small chain) family protein	Arabidopsis thaliana	196-203
16179499-10	2005	Hygromycin B withdrawal led to the total disappearance of EBV vectors and the resumption of normal XPA or XPC protein levels.	Hygromycin B	0-12	XPA, DNA damage recognition and repair factor	Homo sapiens	99-102
16179499-10	2005	Hygromycin B withdrawal led to the total disappearance of EBV vectors and the resumption of normal XPA or XPC protein levels.	Hygromycin B	0-12	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	106-109
15885099-5	2005	Ers1 is a vacuolar protein whose loss of function results in growth sensitivity to hygromycin B.	Hygromycin B	83-95	cystinosin-like protein ERS1	Saccharomyces cerevisiae S288C	0-4
15757667-3	2005	Upon application of Hygromycin B to chromosomally mKir2.1 expressing cells, significantly lower toxin sensitivity (EC50 15.4 microM) compared to Deltatrk1,2 Deltatok1 cells (EC50 2.6 microM) was observed.	Hygromycin B	20-32	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	50-57
15184059-2	2004	An arl1 Delta ccz1 Delta double mutant was viable but grew slowly, was more sensitive to caffeine, Ca(2+), Zn(2+), and hygromycin B than either single mutant, and had a more severe vacuolar protein sorting phenotype.	Hygromycin B	119-131	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	3-7
15879522-3	2005	Consistent with altered cell surface properties, kti6 cells resist hygromycin B, syringomycin E, and nystatin, antibiotics that require intact membrane potentials or provoke membrane disruption.	Hygromycin B	67-79	inositolphosphotransferase	Saccharomyces cerevisiae S288C	49-53
15184059-2	2004	An arl1 Delta ccz1 Delta double mutant was viable but grew slowly, was more sensitive to caffeine, Ca(2+), Zn(2+), and hygromycin B than either single mutant, and had a more severe vacuolar protein sorting phenotype.	Hygromycin B	119-131	Ccz1p	Saccharomyces cerevisiae S288C	14-18
15104597-4	2004	Like pma1 mutants, kti10 cells lose viability at low pH, indicating a pH homeostasis defect, and resist the antibiotic hygromycin B, uptake of which is known to be Pma1 and Delta Psi sensitive.	Hygromycin B	119-131	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	19-24
15104597-4	2004	Like pma1 mutants, kti10 cells lose viability at low pH, indicating a pH homeostasis defect, and resist the antibiotic hygromycin B, uptake of which is known to be Pma1 and Delta Psi sensitive.	Hygromycin B	119-131	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	164-168
14645527-11	2003	Ubiquitin overexpression rescued cells from additional translational inhibitors such as anisomycin and hygromycin B, suggesting that ubiquitin depletion may constitute a widespread mechanism for the toxicity of translational inhibitors.	Hygromycin B	103-115	ubiquitin	Saccharomyces cerevisiae S288C	0-9
15126631-3	2004	The arl1 mutant was sensitive to toxic cations, including hygromycin B and other aminoglycoside antibiotics, tetramethylammonium ions, methylammonium ions and protons.	Hygromycin B	58-70	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	4-8
15126631-4	2004	The hygromycin-B-sensitive phenotype was suppressed by the inclusion of K(+) and complemented by wild-type ARL1 and an allele of ARL1 predicted to be unbound to nucleotide in vivo.	Hygromycin B	4-16	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	107-111
15126631-4	2004	The hygromycin-B-sensitive phenotype was suppressed by the inclusion of K(+) and complemented by wild-type ARL1 and an allele of ARL1 predicted to be unbound to nucleotide in vivo.	Hygromycin B	4-16	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	129-133
14975746-1	2004	ATC1/LIC4, previously identified as a suppressor of the Li(+)-sensitive phenotype of calcineurin mutants, was also identified as a suppressor of the hygromycin B-sensitive phenotype of strains lacking the G protein gene, ARL1.	Hygromycin B	149-161	Atc1p	Saccharomyces cerevisiae S288C	0-4
14975746-1	2004	ATC1/LIC4, previously identified as a suppressor of the Li(+)-sensitive phenotype of calcineurin mutants, was also identified as a suppressor of the hygromycin B-sensitive phenotype of strains lacking the G protein gene, ARL1.	Hygromycin B	149-161	Atc1p	Saccharomyces cerevisiae S288C	5-9
14975746-2	2004	Although loss of ARL1 confers several phenotypes, including sensitivity to hygromycin B and Li(+), reduced influx of K(+), and increased secretion of carboxypeptidase Y (CPY), loss of ATC1 was without effect by these and other measures.	Hygromycin B	75-87	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	17-21
14645527-11	2003	Ubiquitin overexpression rescued cells from additional translational inhibitors such as anisomycin and hygromycin B, suggesting that ubiquitin depletion may constitute a widespread mechanism for the toxicity of translational inhibitors.	Hygromycin B	103-115	ubiquitin	Saccharomyces cerevisiae S288C	133-142
11557474-0	2001	A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.	Hygromycin B	35-47	ATPase	Escherichia coli	12-18
12478387-4	2002	The trs130(ts1) mutant showed calcofluor white-resistant and hygromycin B-sensitive phenotypes, indicating that the mutant is defective in cell wall integrity.	Hygromycin B	61-73	transport protein particle complex II subunit TRS130	Saccharomyces cerevisiae S288C	4-10
12225850-3	2002	A null mutant of the single yeast SR protein kinase Sky1p is viable but exhibits increased tolerance to diverse toxic cations such as Na(+), Li(+), spermine, tetramethylammonium, hygromycin B and Mn(2+).	Hygromycin B	179-191	serine/threonine protein kinase SKY1	Saccharomyces cerevisiae S288C	52-57
11779561-7	2002	Factors which suppress NSC1-mediated inward currents and inhibit growth of trk1 Delta trk2 Delta cells include (i) elevating extracellular calcium over the range of 10 microM-10 mM, (ii) lowering extracellular pH over the range 7.5-4, (iii) blockade of NSC1 by hygromycin B, and (iv) to a lesser extent by TEA(+).	Hygromycin B	261-273	Trk1p	Saccharomyces cerevisiae S288C	75-79
11702078-2	2001	One copy of the URA3 gene was disrupted using a mutated hygromycin B resistance gene (HYG#).	Hygromycin B	56-68	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	16-20
11557474-5	2001	Here, we show that the antibiotic hygromycin B selectively inhibits the ATPase activity of RbbA.	Hygromycin B	34-46	ATPase	Escherichia coli	72-78
11255253-6	2001	The hygromycin B sensitivity of S. cerevisiae mnn9 null mutant was complemented in the presence of the HpMNN9 gene.	Hygromycin B	4-16	mannosyltransferase complex subunit MNN9	Saccharomyces cerevisiae S288C	46-50
12548976-8	2000	The stable hTERT+ fibroblast clones was established and cultured for long-term in a medium containing hygromycin-B.	Hygromycin B	102-114	telomerase reverse transcriptase	Homo sapiens	11-16
11249205-2	2001	Stably transformed polyclonal cell populations expressing recombinant endostatin were isolated after 4 wk of selection with hygromycin B.	Hygromycin B	124-136	collagen, type XVIII, alpha 1	Mus musculus	70-80
11003661-6	2000	Ptk2 has the strongest effect on Pma1, and ptk2 mutants exhibit a pleiotropic phenotype of tolerance to toxic cations, including sodium, lithium, manganese, tetramethylammonium, hygromycin B, and norspermidine.	Hygromycin B	178-190	protein kinase PTK2	Saccharomyces cerevisiae S288C	43-47
10809683-4	2000	Mutants lacking one or two PMT6 alleles grow normally and contain normal Pmt enzymatic activities in cell extracts but show phenotypes including a partial block of hyphal formation (dimorphism) and a supersensitivity to hygromycin B.	Hygromycin B	220-232	dolichyl-phosphate-mannose-protein mannosyltransferase PMT6	Saccharomyces cerevisiae S288C	27-31
10721705-3	2000	The data presented reveal that mdp1 mutants are also pH sensitive, and hypersensitive to hygromycin B and paromomycin.	Hygromycin B	89-101	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	31-35
10601199-7	1999	Like all members of the S. cerevisiae MNN9 gene family the Camnn9Delta strain is resistant to sodium orthovanadate and sensitive to hygromycin B.	Hygromycin B	132-144	mannosyltransferase complex subunit MNN9	Saccharomyces cerevisiae S288C	38-42
10074137-3	1999	The ski7 mutant was hypersensitive to hygromycin B, a result also suggesting a role in translation.	Hygromycin B	38-50	Ski7p	Saccharomyces cerevisiae S288C	4-8
10207057-6	1999	In addition, hal4 hal5 and trk1 trk2 mutants exhibit similar phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium, tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.	Hygromycin B	236-248	serine/threonine protein kinase SAT4	Saccharomyces cerevisiae S288C	13-17
10207057-6	1999	In addition, hal4 hal5 and trk1 trk2 mutants exhibit similar phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium, tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.	Hygromycin B	236-248	protein kinase HAL5	Saccharomyces cerevisiae S288C	18-22
10400716-5	1999	We found that overexpression of NS2B-NS3, the JEV protease, permeabilized bacterial cells to hygromycin B whereas NS1 expression failed to do so.	Hygromycin B	93-105	KRAS proto-oncogene, GTPase	Homo sapiens	37-40
10024662-3	1999	We found that cwh8 cells were resistant to vanadate and sensitive to hygromycin B, and produced glycoforms of invertase and carboxypeptidase Y with a reduced number of N -chains.	Hygromycin B	69-81	dolichyldiphosphatase	Saccharomyces cerevisiae S288C	14-18
10207057-6	1999	In addition, hal4 hal5 and trk1 trk2 mutants exhibit similar phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium, tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.	Hygromycin B	236-248	Trk1p	Saccharomyces cerevisiae S288C	27-31
10207057-6	1999	In addition, hal4 hal5 and trk1 trk2 mutants exhibit similar phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium, tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.	Hygromycin B	236-248	Trk2p	Saccharomyces cerevisiae S288C	32-36
9858571-7	1999	The rer2 mutant shows several other characteristic phenotypes: slow growth, defects in N and O glycosylation, sensitivity to hygromycin B, and abnormal accumulation of membranes, including the ER and the Golgi membranes.	Hygromycin B	125-137	ditrans,polycis-polyprenyl diphosphate synthase	Saccharomyces cerevisiae S288C	4-8
9753459-4	1998	Expression of vpu in Escherichia coli cells increases membrane permeability to a number of molecules such as 2-nitrophenyl beta-D-galactopyranoside, uridine, the impermeable translation inhibitor hygromycin B, and lysozyme.	Hygromycin B	196-208	Vpu	Human immunodeficiency virus 1	14-17
9753459-5	1998	In addition, transient expression of Vpu in eukaryotic COS cells enhances entry of charged molecules such as hygromycin B and neurobiotin into these cells.	Hygromycin B	109-121	Vpu	Human immunodeficiency virus 1	37-40
1656380-7	1991	An HPRT deficient human cell line was transfected and subsequently selected with hygromycin B for DNA uptake.	Hygromycin B	81-93	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	3-7
9152410-8	1997	Serum biochemical analysis of hygR and wild-type mice treated with lethal doses of hygromycin B indicated liver and kidney damage measured as ALT, AST and BUN.	Hygromycin B	83-95	glutamic pyruvic transaminase, soluble	Mus musculus	142-145
9152410-8	1997	Serum biochemical analysis of hygR and wild-type mice treated with lethal doses of hygromycin B indicated liver and kidney damage measured as ALT, AST and BUN.	Hygromycin B	83-95	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	147-150
8650240-5	1996	Mosquito cells in culture infected with a pantropic vector expressing hygromycin phosphotransferase from the Drosophila hsp70 promoter were resistant to the antibiotic hygromycin B.	Hygromycin B	168-180	Heat-shock-protein-70Ab	Drosophila melanogaster	120-125
7590309-8	1995	The stt3 mutants are sensitive to hygromycin B and resistant to sodium orthovanadate, whose phenotypes are common to those defective in protein glycosylation.	Hygromycin B	34-46	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	4-8
7655019-4	1995	Bcl-XL expression dramatically reduces the cytotoxicity of bleomycin, cisplatin, etoposide, vincristine, hygromycin B, and mycophenolic acid for up to 4 days in culture.	Hygromycin B	105-117	BCL2 like 1	Homo sapiens	0-6
7632460-1	1995	Jurkat cells stably expressing high levels of the HIV-1 Tat protein were generated after transfection with an Epstein-Barr virus-based episomal replicon and selection in hygromycin B.	Hygromycin B	170-182	Tat	Human immunodeficiency virus 1	56-59
8224827-1	1993	The pma1-105 mutation reduces the activity of the yeast plasma membrane H(+)-ATPase and causes cells to be both low pH and ammonium ion sensitive and resistant to the antibiotic hygromycin B.	Hygromycin B	178-190	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	4-8
8224827-8	1993	One gene conversion was obtained in which the resulting PMA1::PMA2 hybrid was low pH-resistant but still hygromycin B-resistant.	Hygromycin B	105-117	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	56-60
8224827-8	1993	One gene conversion was obtained in which the resulting PMA1::PMA2 hybrid was low pH-resistant but still hygromycin B-resistant.	Hygromycin B	105-117	H(+)-exporting P2-type ATPase PMA2	Saccharomyces cerevisiae S288C	62-66
8505307-1	1993	An A135V substitution in the first transmembrane segment of the yeast plasma membrane H(+)-ATPase (PMA1) confers cellular resistance to hygromycin B, exhibits growth sensitivity to low external pH, and results in a defective enzyme that hydrolyzes ATP at 33% of wild type level.	Hygromycin B	136-148	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	99-103
7678602-11	1993	The cDNA for p47-phox was inserted into an EBV-expression vector and stably transfected cell lines were obtained using hygromycin B selection.	Hygromycin B	119-131	neutrophil cytosolic factor 1	Homo sapiens	13-21
9537389-5	1998	Disruption of AGS1 rendered strains supersensitive to hygromycin B and increased their resistance to vanadate.	Hygromycin B	54-66	ubiquitin-binding ESCRT-I subunit protein STP22	Saccharomyces cerevisiae S288C	14-18
9218445-8	1997	The null mutant of MNN6 showed a normal cell growth, less binding to Alcian blue, hypersensitivity to Calcoflour White and hygromycin B, and diminished mannosylphosphate transferase activity toward the endoplasmic reticulum core oligosaccharide acceptors (Man8GlcNAc2-PA and Man5GlcNAc2-PA) in vitro, suggesting the involvement of the MNN6 gene in the endoplasmic reticulum core oligosaccharide phosphorylation.	Hygromycin B	123-135	putative mannosyltransferase	Saccharomyces cerevisiae S288C	19-23
9055074-6	1997	Disruption of HOC1 also resulted in hypersensitivity to Calcofluor White and hygromycin B, phenotypes characteristic of defects in cell wall integrity and protein glycosylation, respectively.	Hygromycin B	77-89	alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	14-18
8936598-4	1996	The human prothrombin gene (FII) was used to monitor expression after initial selection for hygromycin B resistance and DHFR activity.	Hygromycin B	92-104	coagulation factor II, thrombin	Homo sapiens	10-21
8662199-1	1996	The barley leaf scald fungus, Rhynchosporium secalis, was transformed to hygromycin-B and phleomycin resistance using the hph gene from E. coli and the ble gene from Streptoalloteichus hindustanus under the control of Aspergillus nidulans promoter and terminator sequences.	Hygromycin B	73-85	bleomycin resistance protein	Escherichia coli	152-155
8991513-3	1996	We have cloned the MNN10 gene by complementation of the hygromycin B sensitivity conferred by the mutant phenotype.	Hygromycin B	56-68	alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	19-24
1334732-2	1992	The human activated c-H-ras gene was transfected into FDC-P2 cells by electroporation using a high-level expression vector, BMGhph, which contains a partial DNA sequence from bovine papillomavirus (BPV) and a hygromycin B (hmB)-resistant gene as a selectable marker.	Hygromycin B	209-221	HRas proto-oncogene, GTPase	Homo sapiens	20-27
1334732-2	1992	The human activated c-H-ras gene was transfected into FDC-P2 cells by electroporation using a high-level expression vector, BMGhph, which contains a partial DNA sequence from bovine papillomavirus (BPV) and a hygromycin B (hmB)-resistant gene as a selectable marker.	Hygromycin B	223-226	HRas proto-oncogene, GTPase	Homo sapiens	20-27
1394441-2	1992	After selection in hygromycin B, high-level Tat activity was detected in 3 of 18 transfected cell lines.	Hygromycin B	19-31	tyrosine aminotransferase	Homo sapiens	44-47
1793807-2	1991	cDNAs encoding CYP1A2, CYP2A6, and microsomal epoxide hydrolase (mEH) were introduced by using a vector conferring hygromycin B resistance, and cDNAs encoding CYP2E1 and CYP3A4 were introduced by using a vector conferring resistance to 1-histidinol.	Hygromycin B	115-127	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	15-21
1793807-2	1991	cDNAs encoding CYP1A2, CYP2A6, and microsomal epoxide hydrolase (mEH) were introduced by using a vector conferring hygromycin B resistance, and cDNAs encoding CYP2E1 and CYP3A4 were introduced by using a vector conferring resistance to 1-histidinol.	Hygromycin B	115-127	epoxide hydrolase 1	Homo sapiens	35-63
1793807-2	1991	cDNAs encoding CYP1A2, CYP2A6, and microsomal epoxide hydrolase (mEH) were introduced by using a vector conferring hygromycin B resistance, and cDNAs encoding CYP2E1 and CYP3A4 were introduced by using a vector conferring resistance to 1-histidinol.	Hygromycin B	115-127	epoxide hydrolase 1, microsomal	Mus musculus	65-68
34117118-2	2021	Here we show how translocation inhibitors viomycin (Vio), neomycin (Neo), paromomycin (Par), kanamycin (Kan), spectinomycin (Spc), hygromycin B (HygB), and streptomycin (Str, an antibiotic that does not inhibit tRNA movement), affect principal motions of the small ribosomal subunits (SSU) during EF-G-promoted translocation.	Hygromycin B	131-143	G elongation factor mitochondrial 1	Homo sapiens	297-301
1369334-2	1991	Transfection of HeLa cells yielded Hygromycin B resistant cell clones, expressing immunoreactive prochymosin, which was quantitatively secreted into the culture medium.	Hygromycin B	35-47	chymosin	Bos taurus	97-108
1700269-7	1990	A fusion between the S. commune TRP1 and the E. coli HPT genes resulted in only slight or no methylation of both vector and HPT sequences and in a higher hygromycin B resistance level.	Hygromycin B	154-166	HPT	Homo sapiens	53-56
1700269-9	1990	Methylation of the HPT gene was also indicated by the stimulation of growth by 5-azacytidine of transformants on hygromycin B containing medium.	Hygromycin B	113-125	HPT	Homo sapiens	19-22
24177815-3	1984	Promoters and amino terminal coding regions of a heat shock gene, a heat shock cognate gene, and the phosphoglycerate kinase gene from yeast were fused to a bacterial hygromycin B resistance gene.	Hygromycin B	167-179	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	101-124
34095778-0	2021	Inner Nuclear Membrane Asi Ubiquitin Ligase Catalytic Subunits Asi1p and Asi3p, but not Asi2p, confer resistance to aminoglycoside hygromycin B in Saccharomyces cerevisiae.	Hygromycin B	131-143	putative ubiquitin-protein ligase ASI3	Saccharomyces cerevisiae S288C	73-78
34095778-4	2021	Loss of Asi1p or Asi3p, but not Asi2p, sensitized yeast to hygromycin B, which promotes translational infidelity by distorting the ribosome A site.	Hygromycin B	59-71	putative ubiquitin-protein ligase ASI1	Saccharomyces cerevisiae S288C	8-13
34095778-4	2021	Loss of Asi1p or Asi3p, but not Asi2p, sensitized yeast to hygromycin B, which promotes translational infidelity by distorting the ribosome A site.	Hygromycin B	59-71	putative ubiquitin-protein ligase ASI3	Saccharomyces cerevisiae S288C	17-22
35622489-0	2022	APC/C Cdh1p and Slx5p/Slx8p ubiquitin ligases confer resistance to aminoglycoside hygromycin B in Saccharomyces cerevisiae.	Hygromycin B	82-94	Cdh1p	Saccharomyces cerevisiae S288C	6-11
35622489-0	2022	APC/C Cdh1p and Slx5p/Slx8p ubiquitin ligases confer resistance to aminoglycoside hygromycin B in Saccharomyces cerevisiae.	Hygromycin B	82-94	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	16-21
2692850-3	1989	These suppressors, like SUP46, manifest sensitivity to increased temperature and the antibiotics paromomycin and hygromycin B.	Hygromycin B	113-125	ribosomal 40S subunit protein S9B	Saccharomyces cerevisiae S288C	24-29
2912581-6	1989	Expression of the transfected cytochrome P1-450 gene was stable for 20-30 days in the presence of hygromycin B.	Hygromycin B	98-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47
2532214-0	1989	Defective H(+)-ATPase of hygromycin B-resistant pma1 mutants fromSaccharomyces cerevisiae.	Hygromycin B	25-37	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	48-52
2532214-1	1989	Mutations in the plasma membrane H(+)-ATPase gene (PMA1) of Saccharomyces cerevisiae that confer growth resistance to hygromycin B have been shown recently to cause a marked depolarization of whole cell membrane potential (Perlin, D. S., Brown, C. L., and Haber, J. E. (1988) J. Biol.	Hygromycin B	118-130	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	51-55
2532214-4	1989	In this report, the biochemical and genetic properties of H+-ATPases from four prominent hygromycin B-resistant pma1 mutants, pma1-105, pma1-114, pma1-147, and pma1-155, are described.	Hygromycin B	89-101	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	112-116
3056938-0	1988	Membrane potential defect in hygromycin B-resistant pma1 mutants of Saccharomyces cerevisiae.	Hygromycin B	29-41	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	52-56
3056938-1	1988	The proton transport properties of hygromycin B-resistant pma1 mutants which show kinetic defects in the plasma membrane H+-ATPase were examined.	Hygromycin B	35-47	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	58-62
31827577-12	2019	We successfully tested that NAT could be used as a selectable marker for ectopic expression of IFT54-HA in strains with paromomycin and hygromycin B resistance markers.	Hygromycin B	136-148	uncharacterized protein	Chlamydomonas reinhardtii	28-31
33554225-0	2020	Loss of protein quality control gene UBR1 sensitizes Saccharomyces cerevisiae to the aminoglycoside hygromycin B.	Hygromycin B	100-112	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	37-41
33554225-4	2020	Indeed, we found that loss of Ubr1 in the model eukaryotic microorganism Saccharomyces cerevisiae strongly sensitizes cells to hygromycin B, which reduces translational fidelity by causing ribosome A site distortion.	Hygromycin B	127-139	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	30-34
6170728-14	1981	The integrity of the cell membrane in control and in IFN-treated cells was studied by analysing the 86Rb+ ion leakage, the thymidine pool, the chronic uptake and the entry of the translation inhibitor hygromycin B, to which cells are impermeable, at different times after EMC infection.	Hygromycin B	201-213	interferon alpha 1	Homo sapiens	53-56
33640956-8	2021	In addition, we found Trk2 to be important for the tolerance to high KCl and hygromycin B in cells growing on minimal media.	Hygromycin B	77-89	Trk2p	Saccharomyces cerevisiae S288C	22-26
31827577-16	2019	NAT is compatible with paromomycin and hygromycin B resistance genes, which allows for multiple selections.	Hygromycin B	39-51	uncharacterized protein	Chlamydomonas reinhardtii	0-3
29607284-5	2018	When tested for deletion of the S. cerevisiae proline oxidase gene PUT1, the hphEC6 cassette was shown to successfully act as a selection marker on hygromycin B-containing medium.	Hygromycin B	148-160	proline dehydrogenase	Saccharomyces cerevisiae S288C	67-71
32083242-0	2019	TOM1 confers resistance to the aminoglycoside hygromycin B in Saccharomyces cerevisiae.	Hygromycin B	46-58	E3 ubiquitin-protein ligase TOM1	Saccharomyces cerevisiae S288C	0-4