PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25150590-13	2014	Antibodies, however, recognized novel N-terminal epitopes in purified NOTCH3-Fc protein treated with three different reductants (DTT, beta-mercaptoethanol, and TCEP).	tris(2-carboxyethyl)phosphine	160-164	neurogenic locus notch homolog protein 3	Oryctolagus cuniculus	70-76
27983990-5	2016	Here, a simple and efficient selective reduction of the single disulfide bond linking the partial heavy chain and the intact light chain which compose the Fab fragment is accomplished utilizing tris(2-carboxyethyl)phosphine (TCEP) immobilized on agarose beads.	tris(2-carboxyethyl)phosphine	194-223	FA complementation group B	Homo sapiens	155-158
27983990-5	2016	Here, a simple and efficient selective reduction of the single disulfide bond linking the partial heavy chain and the intact light chain which compose the Fab fragment is accomplished utilizing tris(2-carboxyethyl)phosphine (TCEP) immobilized on agarose beads.	tris(2-carboxyethyl)phosphine	225-229	FA complementation group B	Homo sapiens	155-158
27775340-0	2016	Chemical Etching of Bovine Serum Albumin-Protected Au25 Nanoclusters for Label-Free and Separation-Free Ratiometric Fluorescent Detection of Tris(2-carboxyethyl)phosphine.	tris(2-carboxyethyl)phosphine	141-170	albumin	Homo sapiens	27-40
27920276-9	2017	TWA1 has a single cysteine residue, Cys139, yet the dimeric form was preserved when TWA1 was purified in the presence of the reducing agent tris(2-carboxyethyl)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	140-169	GID complex subunit 8	Mus musculus	0-4
27920276-9	2017	TWA1 has a single cysteine residue, Cys139, yet the dimeric form was preserved when TWA1 was purified in the presence of the reducing agent tris(2-carboxyethyl)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	140-169	GID complex subunit 8	Mus musculus	84-88
27920276-9	2017	TWA1 has a single cysteine residue, Cys139, yet the dimeric form was preserved when TWA1 was purified in the presence of the reducing agent tris(2-carboxyethyl)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	171-175	GID complex subunit 8	Mus musculus	0-4
24717766-0	2014	Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels.	tris(2-carboxyethyl)phosphine	22-26	growth associated protein 43	Rattus norvegicus	60-65
24717766-0	2014	Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels.	tris(2-carboxyethyl)phosphine	22-26	neurofilament heavy chain	Rattus norvegicus	79-83
24717766-7	2014	Treatment with TCEP resulted in similar changes in gene levels to TDCPP and led to decreases in the protein levels of GAP43 and the tubulins while increasing the CAMKII and NF-H protein levels.	tris(2-carboxyethyl)phosphine	15-19	growth associated protein 43	Rattus norvegicus	118-123
24717766-7	2014	Treatment with TCEP resulted in similar changes in gene levels to TDCPP and led to decreases in the protein levels of GAP43 and the tubulins while increasing the CAMKII and NF-H protein levels.	tris(2-carboxyethyl)phosphine	15-19	neurofilament heavy chain	Rattus norvegicus	173-177
22242685-8	2012	Perturbation of the inactivation pathway through addition of the reducing agent GSH or TCEP resulted in a concentration-dependent decrease in the level of iNOS S-nitrosation that directly correlated with protection from iNOS inactivation.	tris(2-carboxyethyl)phosphine	87-91	nitric oxide synthase 2	Homo sapiens	155-159
23767049-2	2013	Initially, the carried CeO2 nanoparticles autocatalytically hydrolyzed the phosphate ester bond of l-ascorbic acid 2-phosphate (AAP) to produce a new reactant (l-ascorbic acid, AA), then the generated AA was electrochemically oxidized by the assembled thionine on the Thi-CeO2, and the resultant product was then reduced back to AA by the added tris(2-carboxyethy)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	375-379	serpin family F member 2	Homo sapiens	99-126
23451088-3	2013	In this study, we showed a dose-dependent inhibition in transporter activity of SNAT4 with the treatment of reducing agents, dithiothreitol (DTT) and Tris(2-carboxyethyl)phosphine (TCEP), indicating the possible involvement of disulfide bridge(s).	tris(2-carboxyethyl)phosphine	150-179	solute carrier family 38 member 4	Homo sapiens	80-85
23451088-3	2013	In this study, we showed a dose-dependent inhibition in transporter activity of SNAT4 with the treatment of reducing agents, dithiothreitol (DTT) and Tris(2-carboxyethyl)phosphine (TCEP), indicating the possible involvement of disulfide bridge(s).	tris(2-carboxyethyl)phosphine	181-185	solute carrier family 38 member 4	Homo sapiens	80-85
22707360-1	2012	When lysozyme is dissolved in a neutral HEPES buffer solution (pH = 7.4) with 0.001-0.050 M TCEP added, a fast phase transition process occurs and the resulting novel fiber-like hierarchical supramolecular assemblies made by primary spherical-particle aggregation can function as a "superglue" that binds strongly and quickly onto non-fouling coatings.	tris(2-carboxyethyl)phosphine	92-96	lysozyme	Homo sapiens	5-13
23957891-12	2013	The common biochemical reducing agent tris(2-carboxyethyl)phosphine regenerates enzymatic activity from oxidized PTP1B somewhat faster than the thiol-based reagents, with a rate constant of 1.5 +- 0.5 M(-1) s(-1).	tris(2-carboxyethyl)phosphine	38-67	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	113-118
22868225-4	2012	With either TR/Trx/NADPH or TCEP, wtAS3MT or AS3MT/M287T catalyzed conversion of iAs(III) to MAs(III), methylarsonic acid (MAs(V)), dimethylarsinous acid (DMAs(III)), and dimethylarsinic acid (DMAs(V)); MAs(III) was converted to DMAs(III) and DMAs(V).	tris(2-carboxyethyl)phosphine	28-32	arsenite methyltransferase	Homo sapiens	36-41
22664107-3	2012	Tris(2-carboxyethyl)phosphine (TCEP) was applied to reduce two of the three disulfide bonds in porcine insulin and the reduced disulfide bonds were then alkylated by iodoacetamide.	tris(2-carboxyethyl)phosphine	0-29	insulin	Homo sapiens	103-110
22664107-3	2012	Tris(2-carboxyethyl)phosphine (TCEP) was applied to reduce two of the three disulfide bonds in porcine insulin and the reduced disulfide bonds were then alkylated by iodoacetamide.	tris(2-carboxyethyl)phosphine	31-35	insulin	Homo sapiens	103-110
22242685-8	2012	Perturbation of the inactivation pathway through addition of the reducing agent GSH or TCEP resulted in a concentration-dependent decrease in the level of iNOS S-nitrosation that directly correlated with protection from iNOS inactivation.	tris(2-carboxyethyl)phosphine	87-91	nitric oxide synthase 2	Homo sapiens	220-224
21148546-3	2011	Site-directed mutagenesis suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH rather than the phosphine-based thiol reductant TCEP, to the C449-C452 motif; and the C509-C512 motif was not involved in electron transfer during disulphide formation.	tris(2-carboxyethyl)phosphine	282-286	quiescin sulfhydryl oxidase 1	Homo sapiens	101-105
17452434-7	2007	The use of the non-thiol reductant tris(2-carboxyethyl) phosphine combined with protein engineering enables us to demonstrate the mono-, di- and tri-PEGylation of Fab fragments with a range of PEG size.	tris(2-carboxyethyl)phosphine	35-65	FA complementation group B	Homo sapiens	163-166
19383476-3	2009	We demonstrate here that bovine insulin forms flexible filaments in the presence of a reducing agent, Tris (2-carboxyethyl) phosphine.	tris(2-carboxyethyl)phosphine	102-133	insulin	Bos taurus	32-39
18393442-7	2008	After reduction on immobilized TCEP, the ligated Cys and Sec apoproteins bound up to 2.5 Cu(I) ions per hCCS monomer with both Cu and Se as constituent atoms of the cluster which forms at the domain 3 interface of a hCCS dimer.	tris(2-carboxyethyl)phosphine	31-35	copper chaperone for superoxide dismutase	Homo sapiens	104-108
17600791-4	2007	Two parallel reaction pathways are induced by tris(carboxyethyl)phosphine (TCEP) in cross-linked peptides from BAMG-treated cytochrome c.	tris(2-carboxyethyl)phosphine	75-79	cytochrome c, somatic	Homo sapiens	124-136
17452434-7	2007	The use of the non-thiol reductant tris(2-carboxyethyl) phosphine combined with protein engineering enables us to demonstrate the mono-, di- and tri-PEGylation of Fab fragments with a range of PEG size.	tris(2-carboxyethyl)phosphine	35-65	progestagen associated endometrial protein	Homo sapiens	149-152
17298084-7	2007	Zn2+ also strongly inhibits Erv2p when assayed using tris(2-carboxyethyl)phosphine (TCEP) as the reducing substrate of the oxidase.	tris(2-carboxyethyl)phosphine	53-82	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	28-33
17298084-7	2007	Zn2+ also strongly inhibits Erv2p when assayed using tris(2-carboxyethyl)phosphine (TCEP) as the reducing substrate of the oxidase.	tris(2-carboxyethyl)phosphine	84-88	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	28-33
15485869-2	2004	The dissociation of apo- and metal-bound human copper-zinc superoxide dismutase (SOD1) dimers induced by the chaotrope guanidine hydrochloride (GdnHCl) or the reductant Tris(2-carboxyethyl)phosphine (TCEP) has been analyzed using analytical ultracentrifugation.	tris(2-carboxyethyl)phosphine	169-198	superoxide dismutase 1	Homo sapiens	81-85
17154358-9	2007	In contrast, for thioredoxin a bonding of As that depended on the concentration of the disulfide-reducing agent tris(2-carboxyethyl) phosphine was demonstrated.	tris(2-carboxyethyl)phosphine	112-142	thioredoxin	Homo sapiens	17-28
15485869-2	2004	The dissociation of apo- and metal-bound human copper-zinc superoxide dismutase (SOD1) dimers induced by the chaotrope guanidine hydrochloride (GdnHCl) or the reductant Tris(2-carboxyethyl)phosphine (TCEP) has been analyzed using analytical ultracentrifugation.	tris(2-carboxyethyl)phosphine	200-204	superoxide dismutase 1	Homo sapiens	81-85
15485869-3	2004	Global fitting of sedimentation equilibrium data under native solution conditions (without GdnHCl or TCEP) demonstrate that both the apo- and metal-bound forms of SOD1 are stable dimers.	tris(2-carboxyethyl)phosphine	101-105	superoxide dismutase 1	Homo sapiens	163-167
15485869-6	2004	Reduction of the intrasubunit disulfide bond within each SOD1 subunit by 5-10 mM TCEP promotes dissociation of apo-SOD1 dimers, whereas the metal-bound enzyme remains a stable dimer under these conditions.	tris(2-carboxyethyl)phosphine	81-85	superoxide dismutase 1	Homo sapiens	57-61
15485869-6	2004	Reduction of the intrasubunit disulfide bond within each SOD1 subunit by 5-10 mM TCEP promotes dissociation of apo-SOD1 dimers, whereas the metal-bound enzyme remains a stable dimer under these conditions.	tris(2-carboxyethyl)phosphine	81-85	superoxide dismutase 1	Homo sapiens	115-119
15205369-3	2004	METHODS: TTR was immunoprecipitated from serum by use of a polyclonal antibody and subsequently reduced with tris(2-carboxyethyl)phosphine.	tris(2-carboxyethyl)phosphine	109-138	transthyretin	Homo sapiens	9-12
15217993-5	2004	The purified TTR was reduced with tris(2-carboxyethyl)phosphine and analyzed by MS.	tris(2-carboxyethyl)phosphine	34-63	transthyretin	Homo sapiens	13-16
12005423-3	2001	A novel method based on ion-spray mass spectrometry analysis of cyanylation-induced cleavage products of partially reduced protein with Tris(2-carboxyethyl)phosphine was needed to determine the recombinant ASP1 disulfide bond pairing.	tris(2-carboxyethyl)phosphine	136-165	odorant binding protein 1	Apis mellifera	206-210
12974644-6	2003	Using tris(2-carboxyethyl)phosphine hydrochloride (TCEP), an alternate substrate of QSOX that binds Zn(2+) relatively weakly (unlike dithiothreitol), allows rapid inhibition of oxidase activity to be demonstrated at low micromolar metal levels.	tris(2-carboxyethyl)phosphine	51-55	quiescin sulfhydryl oxidase 1	Homo sapiens	84-88
12781465-3	2003	Incubation of transferrin with reductants, such as dithiothreitol (DTT) or tris(2-carboxyethyl)-phosphine (TCEP), yields an increase in multiple charging observed by ESI-MS and an increase in molecular weight consistent with disulfide reduction.	tris(2-carboxyethyl)phosphine	75-105	transferrin	Homo sapiens	14-25
12781465-3	2003	Incubation of transferrin with reductants, such as dithiothreitol (DTT) or tris(2-carboxyethyl)-phosphine (TCEP), yields an increase in multiple charging observed by ESI-MS and an increase in molecular weight consistent with disulfide reduction.	tris(2-carboxyethyl)phosphine	107-111	transferrin	Homo sapiens	14-25
12458194-2	2003	Decreased metal binding site occupancy and exposure to the disulfide-reducing agents dithiothreitol, Tris(2-carboxyethyl)phosphine (TCEP), or reduced glutathione increased the fraction of anomalously migrating mutant SOD1 proteins.	tris(2-carboxyethyl)phosphine	101-130	superoxide dismutase 1, soluble	Mus musculus	217-221
12458194-2	2003	Decreased metal binding site occupancy and exposure to the disulfide-reducing agents dithiothreitol, Tris(2-carboxyethyl)phosphine (TCEP), or reduced glutathione increased the fraction of anomalously migrating mutant SOD1 proteins.	tris(2-carboxyethyl)phosphine	132-136	superoxide dismutase 1, soluble	Mus musculus	217-221
12458194-4	2003	SOD1 enzymes in spinal cord lysates from G85R and G93A mutant but not wild type SOD1 transgenic mice also exhibited abnormal vulnerability to TCEP, which exposed normally inaccessible cysteine residues to modification by maleimide conjugated to polyethylene glycol.	tris(2-carboxyethyl)phosphine	142-146	superoxide dismutase 1, soluble	Mus musculus	0-4
10926679-1	2000	Tris(2-carboxyethyl)phosphine (TCEP) reduces (cleaves) disulfide bonds of the renal proximal tubule type IIa Na/Pi- cotransporter (rat NaPi IIa) and thereby inhibits its function.	tris(2-carboxyethyl)phosphine	0-29	solute carrier family 34 member 1	Rattus norvegicus	135-143
10926679-1	2000	Tris(2-carboxyethyl)phosphine (TCEP) reduces (cleaves) disulfide bonds of the renal proximal tubule type IIa Na/Pi- cotransporter (rat NaPi IIa) and thereby inhibits its function.	tris(2-carboxyethyl)phosphine	31-35	solute carrier family 34 member 1	Rattus norvegicus	135-143
32955262-8	2020	However, PNGase H+ provides broader specificity and greater tolerance to the disulfide-bond reducing agent TCEP, while PNGase A offers advantages in terms of commercial availability and purity.	tris(2-carboxyethyl)phosphine	107-111	N-glycanase 1	Homo sapiens	9-15
10806385-7	2000	In this paper, we demonstrate that Tris(2-carboxyethyl)phosphine, a specific disulfide reducing agent, allows a continuous reduction of the lipoyl group associated with the H-protein during the course of the reaction catalysed by the L-protein.	tris(2-carboxyethyl)phosphine	35-64	myosin binding protein H	Homo sapiens	173-182
10704515-5	2000	NMDA-evoked whole-cell currents in CA1 neurons in slices were increased by TCEP and subsequently decreased by DTNB or PQQ at the same concentrations that modulated epileptiform activity.	tris(2-carboxyethyl)phosphine	75-79	carbonic anhydrase 1	Rattus norvegicus	35-38
9724530-3	1998	The disulfide structure of recombinant human AGRP was determined by chemical methods using partial reduction with tris(2-carboxyethyl)phosphine under acidic conditions, followed by direct alkylation with N-ethylmaleimide or fluorescein-5-maleimide.	tris(2-carboxyethyl)phosphine	114-143	agouti related neuropeptide	Homo sapiens	45-49
10699356-0	2000	Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents.	tris(2-carboxyethyl)phosphine	134-138	nuclear factor kappa B subunit 1	Homo sapiens	14-23
10699356-0	2000	Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents.	tris(2-carboxyethyl)phosphine	134-138	nuclear factor kappa B subunit 1	Homo sapiens	166-175
10699356-4	2000	In the present studies we evaluated the efficacy of tris(2-carboxyethyl)phosphine-HCl (TCEP), a non-thiol reducing agent which does not bind Hg(2+), on NF-kappaB-DNA binding in vitro, using recombinant p50 protein and a (32)P-labelled kappaB oligonucleotide.	tris(2-carboxyethyl)phosphine	87-91	nuclear factor kappa B subunit 1	Homo sapiens	152-161
10699356-4	2000	In the present studies we evaluated the efficacy of tris(2-carboxyethyl)phosphine-HCl (TCEP), a non-thiol reducing agent which does not bind Hg(2+), on NF-kappaB-DNA binding in vitro, using recombinant p50 protein and a (32)P-labelled kappaB oligonucleotide.	tris(2-carboxyethyl)phosphine	87-91	nuclear factor kappa B subunit 1	Homo sapiens	202-205
10699356-8	2000	In contrast, TCEP promoted NF-kappaB-DNA binding in a dose-related manner in concentrations from 0.25 to 6mM.	tris(2-carboxyethyl)phosphine	13-17	nuclear factor kappa B subunit 1	Homo sapiens	27-36
10699356-9	2000	In the presence of even 6mM TCEP, Hg(2+) prevented NF-kappaB-DNA binding at concentrations as low as 20 microM in binding reactions.	tris(2-carboxyethyl)phosphine	28-32	nuclear factor kappa B subunit 1	Homo sapiens	51-60
10604596-4	1999	The disulfide bonds in the cystine knot structure of Md65-AGRP were partially reduced using tris(2-carboxyethyl) phosphine (TCEP) under acidic conditions, followed by alkylation with N-ethylmaleimide (NEM).	tris(2-carboxyethyl)phosphine	92-122	agouti related neuropeptide	Homo sapiens	58-62
10604596-4	1999	The disulfide bonds in the cystine knot structure of Md65-AGRP were partially reduced using tris(2-carboxyethyl) phosphine (TCEP) under acidic conditions, followed by alkylation with N-ethylmaleimide (NEM).	tris(2-carboxyethyl)phosphine	124-128	agouti related neuropeptide	Homo sapiens	58-62
10462449-9	1999	Affinity of purified fully active TrxR1 to heparin could be induced by reduction with NADPH or tris-(2-carboxyethyl)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	95-125	thioredoxin reductase 1	Homo sapiens	34-39
10462449-9	1999	Affinity of purified fully active TrxR1 to heparin could be induced by reduction with NADPH or tris-(2-carboxyethyl)phosphine (TCEP).	tris(2-carboxyethyl)phosphine	127-131	thioredoxin reductase 1	Homo sapiens	34-39
10452801-2	1999	We compare properties of DTT and TCEP important in protein biochemistry, using the motor enzyme myosin as an example protein.	tris(2-carboxyethyl)phosphine	33-37	myosin heavy chain 14	Homo sapiens	96-102
10452801-5	1999	In contrast, maleimide attachment to myosin was achieved in the presence of TCEP, although with less efficiency than no reductant.	tris(2-carboxyethyl)phosphine	76-80	myosin heavy chain 14	Homo sapiens	37-43
8481542-3	1993	We found that TCEP was suitable for partial reduction of bovine insulin deposited on the target and mixed with either sinapinic acid in MALDI or glycerol and m-nitrobenzyl alcohol in LSIMS.	tris(2-carboxyethyl)phosphine	14-18	insulin	Bos taurus	64-71
34843209-3	2021	In-solution deglycosylation with peptide-N4-(N-acetyl-beta-d-glucosaminyl)-asparagine amidase A (PNGase A) or PNGase H+ combined with chemical reduction using tris-(2-carboxyethyl)phosphine (TCEP) has previously been used for HDX-MS analysis of disulfide-linked glycoproteins.	tris(2-carboxyethyl)phosphine	191-195	N-glycanase 1	Homo sapiens	110-116
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	267-296	angiotensin converting enzyme 2	Homo sapiens	165-169
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	298-302	angiotensin converting enzyme 2	Homo sapiens	165-169
35595809-2	2022	Our previous study has shown that insulin forms two types of amyloids; toxic amyloid formed from the intact insulin ((i)-amyloid) and less-toxic amyloid formed in the presence of the reducing reagent TCEP ((r)-amyloid), suggesting insulin amyloid polymorphism.	tris(2-carboxyethyl)phosphine	200-204	insulin	Homo sapiens	34-41
34302317-1	2021	Combining surface-initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI-TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for the generation of stable, polynucleotide brush-functionalized origami nanostructures.	tris(2-carboxyethyl)phosphine	112-116	DNA nucleotidylexotransferase	Homo sapiens	29-32
34302317-1	2021	Combining surface-initiated, TdT (terminal deoxynucleotidyl transferase) catalyzed enzymatic polymerization (SI-TcEP) with precisely engineered DNA origami nanostructures (DONs) presents an innovative pathway for the generation of stable, polynucleotide brush-functionalized origami nanostructures.	tris(2-carboxyethyl)phosphine	112-116	DNA nucleotidylexotransferase	Homo sapiens	34-71
35595809-2	2022	Our previous study has shown that insulin forms two types of amyloids; toxic amyloid formed from the intact insulin ((i)-amyloid) and less-toxic amyloid formed in the presence of the reducing reagent TCEP ((r)-amyloid), suggesting insulin amyloid polymorphism.	tris(2-carboxyethyl)phosphine	200-204	insulin	Homo sapiens	231-238
33633190-5	2021	Here, we report on the enzymatic driven reduction by thioredoxin-1 (recycled by Tris(2-carboxyethyl)phosphine; TCEP) of beta2GPI.	tris(2-carboxyethyl)phosphine	80-109	apolipoprotein H	Homo sapiens	120-128
34986524-6	2022	Mechanistically, tris(2-carboxyethyl) phosphine hydrochloride (TCEP), a specific reducer of cysteine thiol, increased SOD1 monomer formation, thus preventing the NO-induced increase in dismutase activity and the decrease in ROS.	tris(2-carboxyethyl)phosphine	63-67	superoxide dismutase 1	Homo sapiens	118-122
33633190-5	2021	Here, we report on the enzymatic driven reduction by thioredoxin-1 (recycled by Tris(2-carboxyethyl)phosphine; TCEP) of beta2GPI.	tris(2-carboxyethyl)phosphine	111-115	apolipoprotein H	Homo sapiens	120-128
32717533-3	2020	The hTRPA1 activity was abolished by the thiol reducing agent TCEP.	tris(2-carboxyethyl)phosphine	62-66	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-10
33679289-12	2020	Seeding by addition of sonicated fibrils lowered the TCEP concentration needed for fibrillation in both wild-type and AS-SOD1 providing evidence for template-driven structural disturbance that elevated susceptibility to reduction and thus propensity to fibrillate.	tris(2-carboxyethyl)phosphine	53-57	superoxide dismutase 1	Homo sapiens	121-125
33161042-6	2021	First, we showed that the dithiol reducing agent Tris (2-carboxyethyl)-phosphine reduces GC1 response to NO, indicating the significance of Cys oxidation in NO activation.	tris(2-carboxyethyl)phosphine	49-80	olfactomedin 4	Homo sapiens	89-92
32251525-9	2020	RESULTS: 2DE gels of tris(2-carboxyethyl) phosphine extracted JRH improved keratin and KAP resolution and number compared to those of dithiothreitol extracted JRH and published commercially-made second-dimension gels.	tris(2-carboxyethyl)phosphine	21-51	cyclin dependent kinase inhibitor 3	Homo sapiens	87-90
32035620-4	2020	Surprisingly this crotonylation targets serine 46, instead of any predicted lysine residues, of p53, as detected in TCEP-probe labeled crotonylation and anti-crotonylated peptide antibody reaction assays.	tris(2-carboxyethyl)phosphine	116-120	tumor protein p53	Homo sapiens	96-99
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	tris(2-carboxyethyl)phosphine	67-96	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	tris(2-carboxyethyl)phosphine	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
31992623-9	2020	Infection during PDI inhibition was rescued when the bacterial but not host cell surface disulfide bonds were chemically reduced with tris(2-carboxyethyl)phosphine-HCl (TCEP).	tris(2-carboxyethyl)phosphine	134-167	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	17-20
31992623-9	2020	Infection during PDI inhibition was rescued when the bacterial but not host cell surface disulfide bonds were chemically reduced with tris(2-carboxyethyl)phosphine-HCl (TCEP).	tris(2-carboxyethyl)phosphine	169-173	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	17-20
30789702-2	2019	Specifically, alkaline phosphatase (ALP) label was confined via a sandwich immunorecognition to convert 4-aminophenyl phosphate to the signal reporter 4-aminophenol (AP), which was then directed to interact with Ru(NH3)62+ as a redox mediator and tris (2-carboxyethyl) phosphine (TCEP) as reducing agent in the detection buffer.	tris(2-carboxyethyl)phosphine	247-278	alkaline phosphatase, placental	Homo sapiens	14-34
31646444-4	2019	On the contrary, introducing reducing environment by TCEP rescued catalase activity and significantly improved neutrophil survival.	tris(2-carboxyethyl)phosphine	53-57	catalase	Homo sapiens	66-74
30789702-2	2019	Specifically, alkaline phosphatase (ALP) label was confined via a sandwich immunorecognition to convert 4-aminophenyl phosphate to the signal reporter 4-aminophenol (AP), which was then directed to interact with Ru(NH3)62+ as a redox mediator and tris (2-carboxyethyl) phosphine (TCEP) as reducing agent in the detection buffer.	tris(2-carboxyethyl)phosphine	247-278	alkaline phosphatase, placental	Homo sapiens	36-39
30789702-2	2019	Specifically, alkaline phosphatase (ALP) label was confined via a sandwich immunorecognition to convert 4-aminophenyl phosphate to the signal reporter 4-aminophenol (AP), which was then directed to interact with Ru(NH3)62+ as a redox mediator and tris (2-carboxyethyl) phosphine (TCEP) as reducing agent in the detection buffer.	tris(2-carboxyethyl)phosphine	280-284	alkaline phosphatase, placental	Homo sapiens	14-34
30789702-2	2019	Specifically, alkaline phosphatase (ALP) label was confined via a sandwich immunorecognition to convert 4-aminophenyl phosphate to the signal reporter 4-aminophenol (AP), which was then directed to interact with Ru(NH3)62+ as a redox mediator and tris (2-carboxyethyl) phosphine (TCEP) as reducing agent in the detection buffer.	tris(2-carboxyethyl)phosphine	280-284	alkaline phosphatase, placental	Homo sapiens	36-39
29908513-6	2018	Acetylcholinesterase (AChE) in TCEP + PE groups were lower (10%-19%) than those in TCEP groups (p < 0.05).	tris(2-carboxyethyl)phosphine	31-35	acetylcholinesterase	Mus musculus	0-20
30156819-4	2018	Oxidation of thiols by chloramine-T promotes fibronectin (FN) adsorption and fibroblast cell adhesion, whereas the reduction by tris(2-carboxyethyl)phosphine reverses these effects, leading to low FN adsorption and little cell adhesion and spreading.	tris(2-carboxyethyl)phosphine	128-157	fibronectin 1	Homo sapiens	197-199
29908513-6	2018	Acetylcholinesterase (AChE) in TCEP + PE groups were lower (10%-19%) than those in TCEP groups (p < 0.05).	tris(2-carboxyethyl)phosphine	31-35	acetylcholinesterase	Mus musculus	22-26
29851336-2	2018	Specifically, the system was exemplified by the alkaline phosphatase (ALP) catalytic generation of ascorbic acid (AA), the redox cycling of AA by tris (2-carboxyethyl) phosphine (TCEP) as reductant, and the use of a novel Bi2S3/Bi2Sn2O7 heterojunction and myoglobin (Myo) as the photoelectrode and the target, respectively.	tris(2-carboxyethyl)phosphine	179-183	alkaline phosphatase, placental	Homo sapiens	70-73
30143025-9	2018	Next, transcription analysis of in vitro TCEP-induced B. bigemina culture based on an in silico derived list of homologs of Plasmodium falciparum gamete-specific genes demonstrated differential expression of the gene BBBOND_0204030 in induced cells.	tris(2-carboxyethyl)phosphine	41-45	BBBOND_0204030	Babesia bigemina	217-231
29611632-6	2018	The competitive interaction of TCEP with Au nanoplates and microorganisms is used to introduce a homogenous rapid detection method that allows microbial screening in less than 10 min with a limit of detection down to 100 cfu mL-1 .	tris(2-carboxyethyl)phosphine	31-35	L1 cell adhesion molecule	Mus musculus	225-229
29851336-2	2018	Specifically, the system was exemplified by the alkaline phosphatase (ALP) catalytic generation of ascorbic acid (AA), the redox cycling of AA by tris (2-carboxyethyl) phosphine (TCEP) as reductant, and the use of a novel Bi2S3/Bi2Sn2O7 heterojunction and myoglobin (Myo) as the photoelectrode and the target, respectively.	tris(2-carboxyethyl)phosphine	146-177	alkaline phosphatase, placental	Homo sapiens	70-73
29851336-2	2018	Specifically, the system was exemplified by the alkaline phosphatase (ALP) catalytic generation of ascorbic acid (AA), the redox cycling of AA by tris (2-carboxyethyl) phosphine (TCEP) as reductant, and the use of a novel Bi2S3/Bi2Sn2O7 heterojunction and myoglobin (Myo) as the photoelectrode and the target, respectively.	tris(2-carboxyethyl)phosphine	179-183	myoglobin	Homo sapiens	256-265
29851336-3	2018	After the immunoreaction and ALP-induced production of AA, the subsequent oxidation of AA by the photogenerated holes of the Bi2S3/Bi2Sn2O7 heterojunction could be cycled via the regeneration of AA by TCEP from the oxidized product of dehydroascorbic acid, leading to easy signal amplification for the sensitive immunoassay of Myo in real samples.	tris(2-carboxyethyl)phosphine	201-205	alkaline phosphatase, placental	Homo sapiens	29-32
28315670-4	2017	Because of the autoxidation of N-methylisoindole, the sulfatase activity was also tested under reducing conditions, containing either glutathione (GSH) or tris(2-carboxyethyl)phosphine (TCEP), exhibiting little change in kinetic parameters compared to non-reducing conditions.	tris(2-carboxyethyl)phosphine	155-184	arylsulfatase family member H	Homo sapiens	54-63
28315670-4	2017	Because of the autoxidation of N-methylisoindole, the sulfatase activity was also tested under reducing conditions, containing either glutathione (GSH) or tris(2-carboxyethyl)phosphine (TCEP), exhibiting little change in kinetic parameters compared to non-reducing conditions.	tris(2-carboxyethyl)phosphine	186-190	arylsulfatase family member H	Homo sapiens	54-63