PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34295793-4	2021	The role of mEH in endogenous epoxy-fatty acid (EpFA) metabolism has been less well studied.	epfa	48-52	epoxide hydrolase 1, microsomal	Mus musculus	12-15
28259677-3	2017	Inhibition of the sEH maintains the level of endogenous bioactive epoxy-fatty acids (EpFA) and allows them to exert their generally beneficial effects.	epfa	85-89	epoxide hydrolase 2, cytoplasmic	Mus musculus	18-21
32400048-1	2020	Epoxyeicosatrienoic acids (EET) and related epoxy fatty acids (EpFA) are endogenous anti-inflammatory compounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHETs) with lessened biological effects.	epfa	63-67	epoxide hydrolase 2	Homo sapiens	140-165
32400048-1	2020	Epoxyeicosatrienoic acids (EET) and related epoxy fatty acids (EpFA) are endogenous anti-inflammatory compounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHETs) with lessened biological effects.	epfa	63-67	epoxide hydrolase 2	Homo sapiens	167-170
32875445-4	2020	Cytochrome P450 metabolism of specifically long-chain fatty acids forms epoxide metabolites, the epoxy-fatty acids (EpFA).	epfa	116-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
32894508-7	2020	The soluble epoxide hydrolase (sEH) is the major route of metabolism of EpFA.	epfa	72-76	epoxide hydrolase 2	Homo sapiens	4-29
32894508-7	2020	The soluble epoxide hydrolase (sEH) is the major route of metabolism of EpFA.	epfa	72-76	epoxide hydrolase 2	Homo sapiens	31-34
32894508-12	2020	While there are no FDA approved methods that target the sEH or other enzymes responsible for metabolizing EpFA, current clinical efforts to test for efficacy by increasing EpFA that include inhibiting the sEH or administration of EpFA mimics that block metabolism are in progress.	epfa	106-110	epoxide hydrolase 2	Homo sapiens	56-59
34295793-5	2021	In vitro, mEH metabolizes most EpFAs at a far slower rate than soluble epoxide hydrolase (sEH) and has thus been generally considered to exert a minor role in EpFA metabolism in vivo.	epfa	159-163	epoxide hydrolase 1, microsomal	Mus musculus	10-13
34295793-7	2021	Recently, however, mEH was found to have a previously unrecognized and substantial role in EpFA metabolism in vivo.	epfa	91-95	epoxide hydrolase 1, microsomal	Mus musculus	19-22
34295793-8	2021	While few studies have examined the role of mEH in cardiovascular homeostasis, there is now substantial evidence that mEH can regulate cardiovascular function through regulation of EpFA metabolism.	epfa	181-185	epoxide hydrolase 1, microsomal	Mus musculus	118-121
33298560-5	2020	The amount of sEH expressed in AD mouse brains correlated with a reduction in brain EpFA concentrations.	epfa	84-88	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-17
33550801-4	2021	The sEH rapidly degrades EpFA; thus, inhibiting sEH increases EpFA in vivo and confers beneficial effects.	epfa	25-29	epoxide hydrolase 2	Homo sapiens	4-7
33550801-4	2021	The sEH rapidly degrades EpFA; thus, inhibiting sEH increases EpFA in vivo and confers beneficial effects.	epfa	25-29	epoxide hydrolase 2	Homo sapiens	48-51
33550801-4	2021	The sEH rapidly degrades EpFA; thus, inhibiting sEH increases EpFA in vivo and confers beneficial effects.	epfa	62-66	epoxide hydrolase 2	Homo sapiens	4-7
33550801-4	2021	The sEH rapidly degrades EpFA; thus, inhibiting sEH increases EpFA in vivo and confers beneficial effects.	epfa	62-66	epoxide hydrolase 2	Homo sapiens	48-51