PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 131-150 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 152-158 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 peroxisome proliferator activated receptor alpha Mus musculus 204-252 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 peroxisome proliferator activated receptor alpha Mus musculus 254-264 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 carnitine palmitoyltransferase 1b, muscle Mus musculus 270-302 35005749-4 2022 Further analysis by western blot analysis showed that OEO treatment made the expression levels of acetyl-CoA carboxylase (ACC) and Cytochrome P450 2E1 (CYP2E1) down-regulated and the expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyltransferase-1 (CPT-1) up-regulated. oeo 54-57 carnitine palmitoyltransferase 1b, muscle Mus musculus 304-309 33544855-4 2021 Dietary supplementation with 150 or 300 mg/kg OEO increased ADFI (P = 0.057) and ADG (P < 0.05). oeo 46-49 ADG Gallus gallus 81-84 31655147-11 2020 Our results revealed that OEO induces apoptosis through ROS generation, mitochondrial membrane potential (DeltaPsim) disruption, caspase3 activation, and DNA damage. oeo 26-29 caspase 3 Mus musculus 129-137 33133458-8 2020 Meanwhile, total protein, albumin, globulin, and H/L ratio were significantly increased in OEO 300 mg kg-1 at day 21. oeo 91-94 serum albumin Coturnix japonica 26-33 32679285-4 2020 In this study, we evaluated the anti-inflammatory/antioxidant activity as well as wound healing capacity of a well-characterized OEO on human keratinocytes NCTC 2544 treated with interferon-gamma (IFN-gamma) and histamine (H) or subjected to a scratch test. oeo 129-132 interferon gamma Homo sapiens 179-195 32679285-4 2020 In this study, we evaluated the anti-inflammatory/antioxidant activity as well as wound healing capacity of a well-characterized OEO on human keratinocytes NCTC 2544 treated with interferon-gamma (IFN-gamma) and histamine (H) or subjected to a scratch test. oeo 129-132 interferon gamma Homo sapiens 197-206 32679285-9 2020 In IFN-gamma and H treated cells, OEO displayed a significant reduction of ROS, ICAM-1, iNOS, COX-2, 8-OHdG, MMP-1, and MMP-12. oeo 34-37 interferon gamma Homo sapiens 3-12 27314026-5 2016 The OEO-treated pigs showed decreased (P < 0.05) endotoxin level in serum and increased (P < 0.05) villus height and expression of occludin and zonula occludens-1 (ZO-1) in the jejunum. oeo 4-7 occludin Sus scrofa 137-145 29606967-1 2018 The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS). oeo 83-86 toll-like receptor 2 Rattus norvegicus 129-136 30049950-4 2018 This study determined whether oregano essential oil (OEO) exerts an anti-inflammatory effect on lipopolysaccharide (LPS)-treated murine macrophage cells (RAW264.7 cells) in vitro and elucidated the possible underlying molecular mechanisms. oeo 53-56 toll-like receptor 4 Mus musculus 116-119 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 interleukin 1 beta Mus musculus 86-104 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 interleukin 1 beta Mus musculus 106-114 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 interleukin 6 Mus musculus 117-130 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 interleukin 6 Mus musculus 132-136 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 tumor necrosis factor Mus musculus 143-170 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 tumor necrosis factor Mus musculus 172-181 30049950-5 2018 The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL). oeo 24-27 toll-like receptor 4 Mus musculus 214-217 30049950-8 2018 The OEO inhibited the LPS-induced elevation of NADPH oxidase and oxidative stress. oeo 4-7 toll-like receptor 4 Mus musculus 22-25 30049950-10 2018 In conclusion, OEO protects against the LPS-induced RAW264.7 cell inflammatory response through the NADPH oxidase/ROS pathway. oeo 15-18 toll-like receptor 4 Mus musculus 40-43 28666108-6 2017 Results indicated that dietary OEO enhanced the sensory attributes and anti-oxidative status of pork meat by improving IMF and n-3 PUFA proportion and antioxidative capacity. oeo 31-34 IMF Sus scrofa 119-122 28666108-6 2017 Results indicated that dietary OEO enhanced the sensory attributes and anti-oxidative status of pork meat by improving IMF and n-3 PUFA proportion and antioxidative capacity. oeo 31-34 Polyunsaturated fatty acid percentage Sus scrofa 131-135 27314026-5 2016 The OEO-treated pigs showed decreased (P < 0.05) endotoxin level in serum and increased (P < 0.05) villus height and expression of occludin and zonula occludens-1 (ZO-1) in the jejunum. oeo 4-7 zonula occludens 1 Sus scrofa 150-168 28105249-6 2016 OEO dose-dependently increased mRNA and protein levels of the nuclear factor-erythroid 2-related factor-2 (Nrf2) target genes Cu/Zn-superoxide dismutase (SOD1) and g-glutamylcysteine ligase (GCLC, GLCM), as well as intracellular concentrations of SOD1 and glutathione. oeo 0-3 superoxide dismutase 1 Sus scrofa 154-158 28105249-6 2016 OEO dose-dependently increased mRNA and protein levels of the nuclear factor-erythroid 2-related factor-2 (Nrf2) target genes Cu/Zn-superoxide dismutase (SOD1) and g-glutamylcysteine ligase (GCLC, GLCM), as well as intracellular concentrations of SOD1 and glutathione. oeo 0-3 glutamate-cysteine ligase catalytic subunit Sus scrofa 191-195 28105249-6 2016 OEO dose-dependently increased mRNA and protein levels of the nuclear factor-erythroid 2-related factor-2 (Nrf2) target genes Cu/Zn-superoxide dismutase (SOD1) and g-glutamylcysteine ligase (GCLC, GLCM), as well as intracellular concentrations of SOD1 and glutathione. oeo 0-3 superoxide dismutase 1 Sus scrofa 247-251 28105249-8 2016 The OEO-induced expression of Nrf2-regulated genes and increased SOD1 and glutathione concentrations in IPEC-J2 cells were reduced by Nrf2 small interfering (si) RNAs, counteracting the protective effects of OEO against oxidative stress in IPEC-J2 cells. oeo 4-7 superoxide dismutase 1 Sus scrofa 65-69