PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20175231-0	2010	[Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells].	caco2	66-71	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
20175231-1	2010	OBJECTIVE: To investigate the effect of tBHQ and sulforaphane on the protein expression in Nrf2-ARE signaling pathway of Caco2 cells.	caco2	121-126	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	caco2	86-91	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	caco2	86-91	aldo-keto reductase family 1 member C1	Homo sapiens	15-21
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	caco2	86-91	NAD(P)H quinone dehydrogenase 1	Homo sapiens	26-30
18228100-13	2008	Cyclooxygenase-2 inhibition by NS398 showed decreased matrix metalloproteinases-2 expression in HT29 and CaCO2, but not Colo205, reversible with prostaglandin-E2.	caco2	105-110	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
19233848-5	2009	Using polarized human intestinal Caco2 and T84 cells and non-transformed IEC6 cells, HBD2 was equipotent to CCL20 in stimulating migration.	caco2	33-38	defensin beta 4A	Homo sapiens	85-89
18688861-7	2008	GSTP1 expression was more than 10 times higher in the thiazolide-sensitive Caco2 cells than in the less sensitive HFF cells.	caco2	75-80	glutathione S-transferase pi 1	Homo sapiens	0-5
18663533-6	2008	RESULTS: With NaBT treatment, CD44 expression was greatly downregulated in both HT29 and Caco2 (HT29: nontreatment versus treatment; 77.8% versus 0.6%, Caco2: 14.0% versus 0.4%, respectively), more than CD133 expression (HT29: nontreatment versus treatment; 90.1% versus 67.7%, Caco2: 98.9% versus 76.3%, respectively).	caco2	89-94	CD44 molecule (Indian blood group)	Homo sapiens	30-34
18663533-6	2008	RESULTS: With NaBT treatment, CD44 expression was greatly downregulated in both HT29 and Caco2 (HT29: nontreatment versus treatment; 77.8% versus 0.6%, Caco2: 14.0% versus 0.4%, respectively), more than CD133 expression (HT29: nontreatment versus treatment; 90.1% versus 67.7%, Caco2: 98.9% versus 76.3%, respectively).	caco2	152-157	CD44 molecule (Indian blood group)	Homo sapiens	30-34
18663533-6	2008	RESULTS: With NaBT treatment, CD44 expression was greatly downregulated in both HT29 and Caco2 (HT29: nontreatment versus treatment; 77.8% versus 0.6%, Caco2: 14.0% versus 0.4%, respectively), more than CD133 expression (HT29: nontreatment versus treatment; 90.1% versus 67.7%, Caco2: 98.9% versus 76.3%, respectively).	caco2	152-157	CD44 molecule (Indian blood group)	Homo sapiens	30-34
18187048-5	2008	In contrast, the CDX1 promoter is methylated in Caco2/TC7.	caco2	48-53	caudal type homeobox 1	Homo sapiens	17-21
18397763-4	2008	An siRNA oligonucleotide specific for HNF1alpha reduced HNF1alpha protein levels by up to 70% in transient transfections of Caco2 cells.	caco2	124-129	HNF1 homeobox A	Homo sapiens	38-47
18397763-4	2008	An siRNA oligonucleotide specific for HNF1alpha reduced HNF1alpha protein levels by up to 70% in transient transfections of Caco2 cells.	caco2	124-129	HNF1 homeobox A	Homo sapiens	56-65
18395083-10	2008	CD8(+) T-cell lines released both granzyme-B and interferon-gamma following recognition of pA2 when presented by Caco2 and not by HT29.	caco2	113-118	CD8a molecule	Homo sapiens	0-3
18395083-10	2008	CD8(+) T-cell lines released both granzyme-B and interferon-gamma following recognition of pA2 when presented by Caco2 and not by HT29.	caco2	113-118	granzyme B	Homo sapiens	34-44
18395083-10	2008	CD8(+) T-cell lines released both granzyme-B and interferon-gamma following recognition of pA2 when presented by Caco2 and not by HT29.	caco2	113-118	interferon gamma	Homo sapiens	49-65
19404207-11	2009	TNF-alpha produced by activated lymphocytes inhibited iron export from CaCo2 cells.	caco2	71-76	tumor necrosis factor	Homo sapiens	0-9
19452451-0	2009	Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.	caco2	96-101	hephaestin	Homo sapiens	10-20
19452451-6	2009	Furthermore, the decrease in hephaestin levels correlates with a decrease of (55)Fe release from the basolateral side of Caco2 cells.	caco2	121-126	hephaestin	Homo sapiens	29-39
19144638-3	2009	In this study, we investigated the long term effect of leptin on PepT1 levels and activity in Caco2 cell monolayers in vitro.	caco2	94-99	leptin	Homo sapiens	55-61
19144638-3	2009	In this study, we investigated the long term effect of leptin on PepT1 levels and activity in Caco2 cell monolayers in vitro.	caco2	94-99	solute carrier family 15 member 1	Homo sapiens	65-70
17655740-6	2008	Here we show that Caco2 spent medium (SM) induces tolerogenic DC with lower expression of maturation markers, interleukin (IL)-12p70, and tumour necrosis factor-alpha when matured with G+ and Gram-negative (G-) commensals, while IL-10 production is enhanced in DC upon encountering G+ commensals and reduced upon encountering G- bacteria.	caco2	18-23	interleukin 10	Homo sapiens	229-234
17955455-7	2007	Both the full-length 74 kDa kindlin-1 protein and a 43 kDa isoform were detected in CaCo2 cells, the latter resulting from alternative splicing.	caco2	84-89	FERM domain containing kindlin 1	Homo sapiens	28-37
17932227-5	2007	PepT1 colocalized with lipid raft markers GM1 and N-aminopeptidase in intestinal BBMs and Caco2-BBE cell membranes.	caco2	90-95	solute carrier family 15 member 1	Homo sapiens	0-5
17786952-5	2007	In Caco2/TC7 enterocytes, we could disconnect the sensing triggered by detector from that produced by metabolism, and found that GLUT2 generated a metabolism-independent pathway to stimulate the expression of SI and L-PK.	caco2	3-8	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	129-134
16685273-5	2006	Expression of COX-2 was upregulated 1.7-fold in LT97 cells and 1.5-fold in Caco2 2 h after prostaglandin (PG) addition by a p38-mediated pathway.	caco2	75-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
17655843-7	2007	Conditioned medium from UK14304-treated CaCo2-3B stimulates ERK in parental CaCo2 by a mechanism sensitive to EGF receptor and PI3-kinase inhibitors.	caco2	40-45	mitogen-activated protein kinase 1	Homo sapiens	60-63
17655843-7	2007	Conditioned medium from UK14304-treated CaCo2-3B stimulates ERK in parental CaCo2 by a mechanism sensitive to EGF receptor and PI3-kinase inhibitors.	caco2	40-45	epidermal growth factor receptor	Homo sapiens	110-122
17234746-3	2007	Here we report, using a two-hybrid assay, a direct molecular interaction between TSC2 C-terminal part and PDZ 2 and 3 of PATJ, a scaffold member of the Crumbs 3 (CRB 3) complex in human intestinal epithelial cells, Caco2.	caco2	215-220	TSC complex subunit 2	Homo sapiens	81-85
17234746-3	2007	Here we report, using a two-hybrid assay, a direct molecular interaction between TSC2 C-terminal part and PDZ 2 and 3 of PATJ, a scaffold member of the Crumbs 3 (CRB 3) complex in human intestinal epithelial cells, Caco2.	caco2	215-220	PATJ crumbs cell polarity complex component	Homo sapiens	121-125
17234746-3	2007	Here we report, using a two-hybrid assay, a direct molecular interaction between TSC2 C-terminal part and PDZ 2 and 3 of PATJ, a scaffold member of the Crumbs 3 (CRB 3) complex in human intestinal epithelial cells, Caco2.	caco2	215-220	crumbs cell polarity complex component 3	Homo sapiens	152-160
17234746-3	2007	Here we report, using a two-hybrid assay, a direct molecular interaction between TSC2 C-terminal part and PDZ 2 and 3 of PATJ, a scaffold member of the Crumbs 3 (CRB 3) complex in human intestinal epithelial cells, Caco2.	caco2	215-220	crumbs cell polarity complex component 3	Homo sapiens	162-167
17023546-11	2007	Finally, we demonstrated that a reduction of Sp1 or NF-kappaB expression reduced CD98 protein expression in unstimulated and IFN-gamma-stimulated Caco2-BBE cells.	caco2	146-151	solute carrier family 3 member 2	Homo sapiens	81-85
17023546-11	2007	Finally, we demonstrated that a reduction of Sp1 or NF-kappaB expression reduced CD98 protein expression in unstimulated and IFN-gamma-stimulated Caco2-BBE cells.	caco2	146-151	interferon gamma	Homo sapiens	125-134
16986515-4	2006	Expression of ZIP4 on 10 micromol/L TPEN exposure after 0, 2, 4, 6, 8 and 10 hours in Caco2 cells and its expression on various concentration of TPEN exposure (0,2.5,5,7.5 and 10 micromol/L) was measured by RT-PCR.	caco2	86-91	solute carrier family 39 member 4	Homo sapiens	14-18
17601486-7	2007	Conversely, perillyl alcohol but not genistein decreased 4E-BP1(Thr37) phosphorylation in Caco2.	caco2	90-95	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	57-63
17549384-11	2007	We found that LPS stimulation resulted in significant TLR4 upregulation in cells expressing lower constitutive TLR4 levels such as CaCo2, whereas no significant response to LPS was observed in cells characterized by relatively high amounts of constitutive TLR4.	caco2	131-136	toll like receptor 4	Homo sapiens	54-58
17549384-11	2007	We found that LPS stimulation resulted in significant TLR4 upregulation in cells expressing lower constitutive TLR4 levels such as CaCo2, whereas no significant response to LPS was observed in cells characterized by relatively high amounts of constitutive TLR4.	caco2	131-136	toll like receptor 4	Homo sapiens	111-115
17549384-11	2007	We found that LPS stimulation resulted in significant TLR4 upregulation in cells expressing lower constitutive TLR4 levels such as CaCo2, whereas no significant response to LPS was observed in cells characterized by relatively high amounts of constitutive TLR4.	caco2	131-136	toll like receptor 4	Homo sapiens	111-115
17727793-3	2007	The purpose of this study was to determine if the hPEPT1 substrate, cephalexin, inhibits the absorption of the N-formylated peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine ("fMLP"), thereby preventing hyperpermeability in Caco2 cells.	caco2	229-234	solute carrier family 15 member 1	Homo sapiens	50-56
16685273-5	2006	Expression of COX-2 was upregulated 1.7-fold in LT97 cells and 1.5-fold in Caco2 2 h after prostaglandin (PG) addition by a p38-mediated pathway.	caco2	75-80	mitogen-activated protein kinase 14	Homo sapiens	124-127
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	caco2	85-90	interleukin 1 beta	Homo sapiens	107-125
16129888-3	2005	We have produced downregulated PATJ stable lines of Caco2 to clarify its role in epithelial morphogenesis.	caco2	52-57	PATJ crumbs cell polarity complex component	Homo sapiens	31-35
16047468-10	2005	The induction of hBD-2 expression in cytokine-stimulated CaCo2 cells by corticosteroids indicates further immunomodulatory ability of steroid hormones not yet understood.	caco2	57-62	defensin beta 4A	Homo sapiens	17-22
15920415-2	2005	METHODS: Caco2 intestinal cell monolayers were challenged with recombinant tumor necrosis factor (TNF).	caco2	9-14	tumor necrosis factor	Homo sapiens	75-96
15920415-2	2005	METHODS: Caco2 intestinal cell monolayers were challenged with recombinant tumor necrosis factor (TNF).	caco2	9-14	tumor necrosis factor	Homo sapiens	98-101
15749028-4	2005	IL-8 increased DNA synthesis of Caco2 in a dose dependent manner and this was inhibited by ADAM, EGFR kinase, and MEK inhibitors.	caco2	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15749028-4	2005	IL-8 increased DNA synthesis of Caco2 in a dose dependent manner and this was inhibited by ADAM, EGFR kinase, and MEK inhibitors.	caco2	32-37	epidermal growth factor receptor	Homo sapiens	97-101
15749028-4	2005	IL-8 increased DNA synthesis of Caco2 in a dose dependent manner and this was inhibited by ADAM, EGFR kinase, and MEK inhibitors.	caco2	32-37	mitogen-activated protein kinase kinase 7	Homo sapiens	114-117
11375948-7	2001	In addition, the tagged protein retains the capability of di/tripeptide absorption, and the expression of the tagged protein by HT29-Cl.19A cells permits absorption of N-formyl-methionyl-leucyl-phenylalanine (fMLP), as occurs in hPepT1 expressing Caco2-BBE cells.	caco2	247-252	formyl peptide receptor 1	Homo sapiens	209-213
15121760-5	2004	LRH-1 overexpression increased promoter activity up to 1.6-fold and 3-fold in Caco2 and 293 cells, respectively.	caco2	78-83	nuclear receptor subfamily 5 group A member 2	Homo sapiens	0-5
12716892-5	2003	ICAM-1 was found to be expressed to the basolateral domain and to selectively coimmunoprecipitate with CD98/LAT-2 in Caco2-BBE monolayers.	caco2	117-122	intercellular adhesion molecule 1	Homo sapiens	0-6
12716892-5	2003	ICAM-1 was found to be expressed to the basolateral domain and to selectively coimmunoprecipitate with CD98/LAT-2 in Caco2-BBE monolayers.	caco2	117-122	solute carrier family 7 member 5	Homo sapiens	103-107
12716892-5	2003	ICAM-1 was found to be expressed to the basolateral domain and to selectively coimmunoprecipitate with CD98/LAT-2 in Caco2-BBE monolayers.	caco2	117-122	linker for activation of T cells family member 2	Homo sapiens	108-113
11479293-8	2001	Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47.	caco2	153-158	CD47 molecule	Homo sapiens	53-57
11479293-8	2001	Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47.	caco2	153-158	CD47 molecule	Homo sapiens	115-119
11479293-8	2001	Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47.	caco2	153-158	CD47 molecule	Homo sapiens	115-119
11112775-0	2001	Identification of a novel cis element required for cell density-dependent down-regulation of insulin-like growth factor-2 P3 promoter activity in Caco2 cells.	caco2	146-151	insulin like growth factor 2	Homo sapiens	93-121
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	caco2	85-90	interleukin 1 beta	Homo sapiens	127-136
7595067-10	1995	In Caco2 cells, 25-hydrocholesterol lowered LDL-receptor activity, mRNA, and transcription by approximately 35%.	caco2	3-8	low density lipoprotein receptor	Homo sapiens	44-56
10912801-1	2000	Using the basolateral mutant PS of the normally apical neurotrophin receptor p75 (p75NTR) we have identified two cytoplasmic determinants responsible for this reversed localization in the human intestinal cell line, Caco2.	caco2	216-221	brain derived neurotrophic factor	Homo sapiens	55-67
10912801-1	2000	Using the basolateral mutant PS of the normally apical neurotrophin receptor p75 (p75NTR) we have identified two cytoplasmic determinants responsible for this reversed localization in the human intestinal cell line, Caco2.	caco2	216-221	PC4 and SFRS1 interacting protein 1	Homo sapiens	77-80
10912801-1	2000	Using the basolateral mutant PS of the normally apical neurotrophin receptor p75 (p75NTR) we have identified two cytoplasmic determinants responsible for this reversed localization in the human intestinal cell line, Caco2.	caco2	216-221	nerve growth factor receptor	Homo sapiens	82-88
10556483-7	1999	In Caco2 cells and in normal human intestine, SVCT1 also exists as a non-functional splice variant with a four amino acid sequence inserted between E-155 and V-156.	caco2	3-8	solute carrier family 23 member 1	Homo sapiens	46-51
10542336-6	1999	ERGIC-53 is expressed as a major transcript of about 5.5 kb in either monkey CV1 or in human CaCo2.	caco2	93-98	lectin, mannose binding 1	Homo sapiens	0-8
9205074-2	1997	Here we show that the small stress protein HSP27, which has been described to block necrotic and apoptotic cell death, accumulates in confluent human colorectal cancer cell lines HT-29 and Caco2.	caco2	189-194	heat shock protein family B (small) member 1	Homo sapiens	43-48
10974555-5	2000	Using the reverse transcription-polymerase chain reaction (RT-PCR) method, the messenger RNA of gp91-2 was detected mainly in the colon (and also in kidney and prostate) among human adult tissues, in the thymus among human fetal tissues, and in the cancer cell lines (HepG2 and Caco2).	caco2	278-283	NADPH oxidase 1	Homo sapiens	96-102
10660549-3	2000	We examined apoB-100 and apoB-48 biogenesis in CaCo2, a human colon carcinoma cell line.	caco2	47-52	apolipoprotein B	Homo sapiens	12-20
10660549-3	2000	We examined apoB-100 and apoB-48 biogenesis in CaCo2, a human colon carcinoma cell line.	caco2	47-52	apolipoprotein B	Homo sapiens	25-32
10660549-4	2000	To our surprise, apoB-100 and apoB-48 were quantitatively secreted by CaCo2 cells; essentially none of the newly synthesized apoB was degraded before secretion in a 2-h period whether the cells were cultured on filter or on plastic.	caco2	70-75	apolipoprotein B	Homo sapiens	17-25
10660549-4	2000	To our surprise, apoB-100 and apoB-48 were quantitatively secreted by CaCo2 cells; essentially none of the newly synthesized apoB was degraded before secretion in a 2-h period whether the cells were cultured on filter or on plastic.	caco2	70-75	apolipoprotein B	Homo sapiens	30-37
10660549-4	2000	To our surprise, apoB-100 and apoB-48 were quantitatively secreted by CaCo2 cells; essentially none of the newly synthesized apoB was degraded before secretion in a 2-h period whether the cells were cultured on filter or on plastic.	caco2	70-75	apolipoprotein B	Homo sapiens	17-21
10660549-7	2000	Incubation in lipoprotein-deficient serum did not induce apoB degradation, but the addition of a microsomal triglyceride transfer protein inhibitor led to apoB degradation in CaCo2 cells.	caco2	175-180	apolipoprotein B	Homo sapiens	155-159
10623446-3	2000	The effect of modulating IL-8 activity upon the growth of the colon carcinoma cell lines HCT116A, HT29 and CaCo2 was investigated.	caco2	107-112	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
7595067-15	1995	However, LDL-receptor mRNA decreased by approximately 50% in HepG2 cells and 30-40% in Caco2 cells.	caco2	87-92	low density lipoprotein receptor	Homo sapiens	9-21
1719762-5	1991	In contrast, levels of CFTR mRNA increase by a factor of 10-20 as Caco2 cells grow after subculture.	caco2	66-71	CF transmembrane conductance regulator	Homo sapiens	23-27
1400359-1	1992	The promoter of the pig lactase-phlorizin hydrolase was cloned and showed to be functional in the human intestinal cell line Caco2.	caco2	125-130	lactase phlorizin hydrolase	Sus scrofa	24-51
7769122-4	1995	We found that CaCo2-ras cells, but not parental CaCo2, express high levels of the human NT/N gene and, moreover, that this increase in gene expression is regulated at the level of transcription.	caco2	14-19	neurotensin	Homo sapiens	88-92
7756263-4	1995	To test the ability of CEH to promote micellar cholesterol uptake in a CaCo2 system under more physiological conditions, an in vitro model was developed.	caco2	71-76	carboxylesterase 1	Homo sapiens	23-26
35474907-8	2022	Importance: SARS-CoV-2 isolate (SARS-CoV-2/human/KOR/KCDC03-NCCP43326/2020) was serially passaged in A549, CaCO2, and HRT-18 cells in triplicate.	caco2	107-112	opioid receptor kappa 1	Homo sapiens	49-52
2785994-8	1989	Functionally active alpha 1-AT is secreted into the basolateral and apical (luminal) fluid in pulse-chase labeling experiments of Caco2 cells cultured in polarized orientation on collagen-coated nitrocellulose membranes.	caco2	130-135	serpin family A member 1	Homo sapiens	20-30
2785994-9	1989	Expression of alpha 1-AT in Caco2 enterocytes is not affected by soluble factors that regulate expression of alpha 1-AT in macrophages and hepatocytes.	caco2	28-33	serpin family A member 1	Homo sapiens	14-24
32565024-8	2020	The expression level of SGK2 have positive correlation with expression of mesenchymal marker N-cadherin and Vimentin and negative correlation with the expression of epithelial marker E-cadherin in CACO2 and HCT116 cells.	caco2	197-202	serum/glucocorticoid regulated kinase 2	Homo sapiens	24-28
33891011-9	2021	Knock-down of STXBP3 in CaCo2 cells resulted in defects in cell polarity.	caco2	24-29	syntaxin binding protein 3	Homo sapiens	14-20
33957538-7	2021	The treatment of both Caco2 (not metastatic) and HCT-116 (metastatic) colon carcinoma cells with 3a or 3b triggered a significant induction of apoptosis as demonstrated by the increased expression of cleaved-poly(ADP-ribose) polymerase (PARP), receptor-interacting protein (RIP) and caspase-3 proteins.	caco2	22-27	poly(ADP-ribose) polymerase 1	Homo sapiens	208-235
33967625-12	2021	In vitro experiments revealed that Xi Lei San could repress apoptosis as well as ROS and inflammatory cytokine production in TNF-alpha-induced CACO2 cells by reducing the activity of NLRP3 inflammasomes and autophagy.	caco2	143-148	tumor necrosis factor	Homo sapiens	125-134
33967625-12	2021	In vitro experiments revealed that Xi Lei San could repress apoptosis as well as ROS and inflammatory cytokine production in TNF-alpha-induced CACO2 cells by reducing the activity of NLRP3 inflammasomes and autophagy.	caco2	143-148	NLR family pyrin domain containing 3	Homo sapiens	183-188
32565024-8	2020	The expression level of SGK2 have positive correlation with expression of mesenchymal marker N-cadherin and Vimentin and negative correlation with the expression of epithelial marker E-cadherin in CACO2 and HCT116 cells.	caco2	197-202	cadherin 1	Homo sapiens	183-193
31250159-4	2019	Western blot densitometry was used to measure Nrf2 nuclear translocation in Caco2 cells after exposure to RRx-001.	caco2	76-81	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
32707230-6	2020	A single dose of 10 U/mL interferon-beta (IFNbeta) pretreatment potently protected both Calu3 and Caco2 against SARS-CoV-2 infection.	caco2	98-103	interferon beta 1	Homo sapiens	25-40
32707230-6	2020	A single dose of 10 U/mL interferon-beta (IFNbeta) pretreatment potently protected both Calu3 and Caco2 against SARS-CoV-2 infection.	caco2	98-103	interferon alpha 1	Homo sapiens	42-49
32606260-9	2020	Additionally, ephrinA1-Fc led to apparent epithelial leakage in Caco2 monolayer by promoting the phosphorylation of ERK1/2, which could be obviously blocked by ephA2-mab and PD98059.	caco2	64-69	mitogen-activated protein kinase 3	Mus musculus	116-122
32606260-9	2020	Additionally, ephrinA1-Fc led to apparent epithelial leakage in Caco2 monolayer by promoting the phosphorylation of ERK1/2, which could be obviously blocked by ephA2-mab and PD98059.	caco2	64-69	Eph receptor A2	Mus musculus	160-165
32143529-7	2020	Both treatments reduced the levels of SCD1, phospho-Rac1/Cdc42/Rac1/Cdc42 ratio, Cofilin, Vimentin, and phospho-Paxillin especially in Caco2 compared to SW480, showing a different behavior of the two cell lines to these natural compounds.	caco2	135-140	vimentin	Homo sapiens	90-98
32143529-7	2020	Both treatments reduced the levels of SCD1, phospho-Rac1/Cdc42/Rac1/Cdc42 ratio, Cofilin, Vimentin, and phospho-Paxillin especially in Caco2 compared to SW480, showing a different behavior of the two cell lines to these natural compounds.	caco2	135-140	paxillin	Homo sapiens	112-120
31665381-9	2020	In vitro, both Caco2 and HT-29 cells responded to 25(OH)D treatment with 200-fold and 175-fold greater effective concentration at 50% maximal response than 1,25(OH)2D, yet inhibition of 1alpha-OHase and knockdown of CYP27B1 had no effect on the responses.	caco2	15-20	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	216-223
31140746-3	2019	METHODS AND RESULTS: The effects of hMOs and NDCs on human gut epithelial cells (Caco2) are investigated by quantifying thickness and area coverage of adsorbed albumin, heparan sulfate (HS), and hyaluronic acid (HA) in the glycocalyx.	caco2	81-86	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	36-40
31163602-13	2019	extract promotes an oxidative cellular microenvironment resulting in CaCo2 cell death by ferroptosis mediated by HO-1 hyper-expression.	caco2	69-74	heme oxygenase 1	Homo sapiens	113-117
31172894-2	2019	To investigate the roles ANXA2 plays during the development of cancer, the RNAi method was used to inhibit the ANXA2 expression in caco2 (human colorectal cancer cell line) and SMMC7721 (human hepatocarcinoma cell line) cells.	caco2	131-136	annexin A2	Homo sapiens	111-116
30523271-4	2018	Moreover, the suppressed IL-6 levels down regulated JAK2/STAT3 pathway with decrease inflammation-mediated Hamp mRNA transcription (HepG2) and increase iron absorption (Caco2) in HepG2/Caco2 co-culture model.	caco2	169-174	interleukin 6	Mus musculus	25-29
31167694-4	2019	Western blot analysis was performed to detect the SHMT2 protein levels of SW480, SW620, HCT116, CACO2, RKO, HCT8, HT15 and HT29 cells.	caco2	96-101	serine hydroxymethyltransferase 2	Homo sapiens	50-55
30985981-8	2019	Inhibition of Hsp90 by SNX-2112 induced the degradation of phosphorylated AKT and ERK1/2 in Caco2 and HRT18 cells.	caco2	92-97	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
30985981-8	2019	Inhibition of Hsp90 by SNX-2112 induced the degradation of phosphorylated AKT and ERK1/2 in Caco2 and HRT18 cells.	caco2	92-97	AKT serine/threonine kinase 1	Homo sapiens	74-77
30985981-8	2019	Inhibition of Hsp90 by SNX-2112 induced the degradation of phosphorylated AKT and ERK1/2 in Caco2 and HRT18 cells.	caco2	92-97	mitogen-activated protein kinase 3	Homo sapiens	82-88
30598703-10	2018	Our finding indicates that the downregulation of VEGF protein level is also effectively observed only in DHA-treated HCT116 and Caco2 cells compared to control cells (p < 0.05).	caco2	128-133	vascular endothelial growth factor A	Homo sapiens	49-53
30523271-4	2018	Moreover, the suppressed IL-6 levels down regulated JAK2/STAT3 pathway with decrease inflammation-mediated Hamp mRNA transcription (HepG2) and increase iron absorption (Caco2) in HepG2/Caco2 co-culture model.	caco2	169-174	Janus kinase 2	Mus musculus	52-56
30523271-4	2018	Moreover, the suppressed IL-6 levels down regulated JAK2/STAT3 pathway with decrease inflammation-mediated Hamp mRNA transcription (HepG2) and increase iron absorption (Caco2) in HepG2/Caco2 co-culture model.	caco2	169-174	signal transducer and activator of transcription 3	Mus musculus	57-62
30009860-12	2018	Our data shows that treatment with 27-OHC substantially decreases the activation of AKT by reducing levels of its active form, p-AKT, in Caco2 cells but not SW620 cells.	caco2	137-142	AKT serine/threonine kinase 1	Homo sapiens	84-87
30095213-5	2018	DGAT1 knockdown in Caco2-BBe cells modeled the deficits in apical trafficking, with loss of apical DPPIV and junctional occludin.	caco2	19-24	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30009860-12	2018	Our data shows that treatment with 27-OHC substantially decreases the activation of AKT by reducing levels of its active form, p-AKT, in Caco2 cells but not SW620 cells.	caco2	137-142	AKT serine/threonine kinase 1	Homo sapiens	129-132
30294327-12	2018	Coculture with colon cancer cells (HT29 and Caco2) induced upregulation of Siglec-6 on MC.	caco2	44-49	sialic acid binding Ig like lectin 6	Homo sapiens	75-83
30111166-3	2018	In the current work, we created miR-206-overexpressing cell lines (HT-1080, Caco2, iASC, and SS-iASC) using permanent transfection.	caco2	76-81	microRNA 206	Homo sapiens	32-39
29584932-6	2018	Thus, the effects of the flavonoids in Caco2 cells on Ah-responsiveness and interactions with butyrate were both ligand structure- and response-dependent and these activities are consistent with hydroxyflavonoids being selective AhR modulators.	caco2	39-44	aryl hydrocarbon receptor	Homo sapiens	229-232
30178853-9	2018	Suppression of miR-19b enhanced the LPS-induced Caco2 cell inflammatory injury, as well as NF-kappaB and PI3K/AKT pathways activation.	caco2	48-53	microRNA 19b-1	Homo sapiens	15-22
30178853-12	2018	Overexpression of Runx3 reversed the miR-19b knockdown-induced Caco2 cell viability inhibition, apoptosis enhancement, inflammatory factors expressions and NF-kappaB and PI3K/AKT signaling pathways activation.	caco2	63-68	RUNX family transcription factor 3	Homo sapiens	18-23
30178853-12	2018	Overexpression of Runx3 reversed the miR-19b knockdown-induced Caco2 cell viability inhibition, apoptosis enhancement, inflammatory factors expressions and NF-kappaB and PI3K/AKT signaling pathways activation.	caco2	63-68	microRNA 19b-1	Homo sapiens	37-44
30178853-13	2018	CONCLUSIONS: Our study demonstrated that miR-19b alleviated LPS-induced Caco2 cell inflammatory injury via up-regulation of Runx3 and deactivation of NF-kappaB and PI3K/AKT signaling pathways.	caco2	72-77	microRNA 19b-1	Homo sapiens	41-48
30178853-13	2018	CONCLUSIONS: Our study demonstrated that miR-19b alleviated LPS-induced Caco2 cell inflammatory injury via up-regulation of Runx3 and deactivation of NF-kappaB and PI3K/AKT signaling pathways.	caco2	72-77	RUNX family transcription factor 3	Homo sapiens	124-129
30178853-13	2018	CONCLUSIONS: Our study demonstrated that miR-19b alleviated LPS-induced Caco2 cell inflammatory injury via up-regulation of Runx3 and deactivation of NF-kappaB and PI3K/AKT signaling pathways.	caco2	72-77	nuclear factor kappa B subunit 1	Homo sapiens	150-159
30178853-13	2018	CONCLUSIONS: Our study demonstrated that miR-19b alleviated LPS-induced Caco2 cell inflammatory injury via up-regulation of Runx3 and deactivation of NF-kappaB and PI3K/AKT signaling pathways.	caco2	72-77	AKT serine/threonine kinase 1	Homo sapiens	169-172
29542325-9	2018	Metformin use reduced MYC levels in Caco2 and consequently, SLC1A5 and GLS expression, with a greater effect in cells dependent on glutaminolytic metabolism.	caco2	36-41	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	22-25
29608915-4	2018	Here, we demonstrated that NUSAP1 gene expression was notably upregulated in CRC tissues and cell lines (Caco2, LS174T, SW480, and LoVo).	caco2	105-110	nucleolar and spindle associated protein 1	Homo sapiens	27-33
30026827-6	2018	MiR-1296 overexpression was detected in five CRC cell lines (HCT116, Caco2, HT29, SW620 and SW480).	caco2	69-74	microRNA 1296	Homo sapiens	0-8
29641917-11	2018	Caspase 3 activity was significantly elevated in Caco2 cells exposed to these extracts, indicating that apoptosis was induced.	caco2	49-54	caspase 3	Homo sapiens	0-9
29110392-4	2018	NHE3 expression was suppressed by siRNA-mediated knockdown or augmented in Caco2 cells.	caco2	75-80	solute carrier family 9 member A3	Homo sapiens	0-4
29636436-7	2018	Furthermore, Abl (HeLa and Caco2) and Lyn (Caco2) were enriched specifically in the EspJ-containing samples.	caco2	27-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	13-16
29636436-7	2018	Furthermore, Abl (HeLa and Caco2) and Lyn (Caco2) were enriched specifically in the EspJ-containing samples.	caco2	43-48	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
29110392-7	2018	RESULTS: NHE3 expression was upregulated in db/db mouse jejunal BBM and high-glucose-treated Caco2 cells.	caco2	93-98	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	9-13
27578247-1	2016	During the lead generation and optimization of PARP inhibitors blocking centrosome clustering, it was discovered that increasing hydrogen bond acceptor (HBA) strength improved cellular potency but led to elevated Caco2 and MDR1 efflux and thus poor oral bioavailability.	caco2	213-218	collagen type XI alpha 2 chain	Homo sapiens	47-51
27805617-6	2017	In a human colon epithelial model using Caco2 cells, CTBp, but not the non-GM1-binding mutant G33D-CTBp, induced TGFbeta-mediated wound healing.	caco2	40-45	phosphate cytidylyltransferase 1B, choline	Homo sapiens	53-57
28594907-12	2017	Interestingly, VEGF inhibition with bevacizumab (100mug/ml) increased hTERT expression 42.3% in AGS, 94.1% in Caco2, and 52.5% in HepG2/C3A, and increased telomerase activity 30-fold in AGS, 10.3-fold in Caco2 and 8-fold in HepG2/C3A.	caco2	204-209	vascular endothelial growth factor A	Homo sapiens	15-19
28594907-12	2017	Interestingly, VEGF inhibition with bevacizumab (100mug/ml) increased hTERT expression 42.3% in AGS, 94.1% in Caco2, and 52.5% in HepG2/C3A, and increased telomerase activity 30-fold in AGS, 10.3-fold in Caco2 and 8-fold in HepG2/C3A.	caco2	204-209	telomerase reverse transcriptase	Homo sapiens	70-75
28241438-4	2017	The uptake of LBP through Caco2 cell monolayer was time-dependent and was inhibited by phloridzin, a competitive inhibitor of SGLT-1.	caco2	26-31	solute carrier family 5 member 1	Homo sapiens	126-132
27203393-4	2017	In addition, we found that the expression of PTRF negatively regulates the tumorigenic activities of colorectal cell lines (Colo320, HT29 and CaCo2).	caco2	142-147	caveolae associated protein 1	Homo sapiens	45-49
27203393-7	2017	In addition, in vivo assays further revealed that tumor growth was significantly inhibited in xenografts with ectopic PTRF expression as compared to untreated Colo320 cells, but was markedly enhanced in PTRF knockdown CaCo2 cells.	caco2	218-223	caveolae associated protein 1	Homo sapiens	203-207
28206713-6	2017	ZO-1 and human HO-1 in Caco2 were significantly decreased after treatment with TNF-alpha; and this effect was reduced when coculture with MSCs from bone marrow.	caco2	23-28	tight junction protein 1	Homo sapiens	0-4
28206713-6	2017	ZO-1 and human HO-1 in Caco2 were significantly decreased after treatment with TNF-alpha; and this effect was reduced when coculture with MSCs from bone marrow.	caco2	23-28	heme oxygenase 1	Homo sapiens	15-19
28206713-6	2017	ZO-1 and human HO-1 in Caco2 were significantly decreased after treatment with TNF-alpha; and this effect was reduced when coculture with MSCs from bone marrow.	caco2	23-28	tumor necrosis factor	Homo sapiens	79-88
28206713-8	2017	In contrast, ZO-1 and human HO-1 increased significantly when the damaged Caco2 was treated with HO-MSCs.	caco2	74-79	tight junction protein 1	Homo sapiens	13-17
28206713-8	2017	In contrast, ZO-1 and human HO-1 increased significantly when the damaged Caco2 was treated with HO-MSCs.	caco2	74-79	heme oxygenase 1	Homo sapiens	28-32
28594907-11	2017	RESULTS: Our results showed that telomerase regulates VEGF expression and secretion through its catalytic subunit hTERT in AGS, Caco2, and HepG2/C3A, independent of its catalytic activity.	caco2	128-133	vascular endothelial growth factor A	Homo sapiens	54-58
28594907-11	2017	RESULTS: Our results showed that telomerase regulates VEGF expression and secretion through its catalytic subunit hTERT in AGS, Caco2, and HepG2/C3A, independent of its catalytic activity.	caco2	128-133	telomerase reverse transcriptase	Homo sapiens	114-119
28594907-12	2017	Interestingly, VEGF inhibition with bevacizumab (100mug/ml) increased hTERT expression 42.3% in AGS, 94.1% in Caco2, and 52.5% in HepG2/C3A, and increased telomerase activity 30-fold in AGS, 10.3-fold in Caco2 and 8-fold in HepG2/C3A.	caco2	110-115	vascular endothelial growth factor A	Homo sapiens	15-19
28452574-7	2017	This inhibitory peptide was used to measure LI-cadherin dependency of water transport through a monolayer of epithelial CACO2 cells under various osmotic conditions.	caco2	120-125	cadherin 17	Homo sapiens	44-55
27837168-4	2017	1,4-DHNA was the most potent compound among hydroxyl/carboxy naphthalene derivatives, and the fold induction response for CYP1A1 and CYP1B1 was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in YAMC and Caco2 cells.	caco2	228-233	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	122-128
27837168-4	2017	1,4-DHNA was the most potent compound among hydroxyl/carboxy naphthalene derivatives, and the fold induction response for CYP1A1 and CYP1B1 was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in YAMC and Caco2 cells.	caco2	228-233	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	133-139
27825133-6	2016	We found that FoxO3a was significantly up-regulated in Caco2-CR as well as in cetuximab treated HT29 cells.	caco2	55-60	forkhead box O3	Homo sapiens	14-20
27760826-7	2016	Interestingly, knockdown of PKCzeta, but not PKCiota, led to similar disruption of the polarized lumen structure, suggesting that PKCzeta likely controls the polarization process of Caco2 cells.	caco2	182-187	protein kinase C zeta	Homo sapiens	28-35
27760826-7	2016	Interestingly, knockdown of PKCzeta, but not PKCiota, led to similar disruption of the polarized lumen structure, suggesting that PKCzeta likely controls the polarization process of Caco2 cells.	caco2	182-187	protein kinase C zeta	Homo sapiens	130-137
27656108-2	2016	We show that the expression of the cancer-promoting phosphatase PRL-3 (PTP4A3), which is overexpressed in several epithelial cancers, in polarized epithelial MDCK and Caco2 cells leads to invasion and the formation of multiple ectopic, fully polarized lumens in cysts.	caco2	167-172	protein tyrosine phosphatase 4A3	Homo sapiens	64-69
27656108-2	2016	We show that the expression of the cancer-promoting phosphatase PRL-3 (PTP4A3), which is overexpressed in several epithelial cancers, in polarized epithelial MDCK and Caco2 cells leads to invasion and the formation of multiple ectopic, fully polarized lumens in cysts.	caco2	167-172	protein tyrosine phosphatase 4A3	Canis lupus familiaris	71-77
27578247-0	2016	Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.	caco2	66-71	collagen type XI alpha 2 chain	Homo sapiens	107-111
27055226-10	2016	REG Ialpha stimulation significantly enhanced the level of TEER in Caco2 cells.	caco2	67-72	regenerating family member 1 alpha	Homo sapiens	0-3
27409607-3	2016	Here, the expression levels of the calcium transport proteins involved in transcellular transport in Caco2 cells were examined following over-expression or inhibition of STC1.	caco2	101-106	stanniocalcin 1	Homo sapiens	170-174
27137347-9	2016	High ODC activity was detected by (13)C-ornithine assay in Caco2 (32.00  +-  1.12 delta (13)CO2) in contrast to HeLa cells (5.44  +-  0.14 delta (13)CO2) cells.	caco2	59-64	ornithine decarboxylase 1	Homo sapiens	5-8
27152243-9	2016	In contrast, MSI-negative CRC cells (Caco2, HT29, SW480) were resistant, except for high doses of FK228 (Caco2, HT29).	caco2	37-42	RB binding protein 4, chromatin remodeling factor	Homo sapiens	13-16
27012226-5	2016	Using intestinal epithelial cells Caco2 as a model, it was shown that MLN could be extensively taken up by Caco2 cells while demonstrating low cytotoxicity.	caco2	34-39	motilin	Homo sapiens	70-73
27012226-5	2016	Using intestinal epithelial cells Caco2 as a model, it was shown that MLN could be extensively taken up by Caco2 cells while demonstrating low cytotoxicity.	caco2	107-112	motilin	Homo sapiens	70-73
26764104-5	2016	Interestingly the equivalent dose of free DOX was more toxic to 3T3 than to Caco2 cells, reducing the 3T3 viability to 72% and the Caco2 viability to 80%, which is likely due to the presence of the p-glycoprotein pumps in Caco2 cells.	caco2	76-81	ATP binding cassette subfamily B member 1	Homo sapiens	198-212
25948514-10	2016	The lower compartment after Caco2-transport experiments up-regulated LDLR and modulated several other lipid-related genes in HepG2 cells.	caco2	28-33	low density lipoprotein receptor	Homo sapiens	69-73
26432753-10	2016	Downmodulation of AURKA expression reduced [(3)H]alisertib uptake in Caco2 cells (P<.01).	caco2	69-74	aurora kinase A	Homo sapiens	18-23
26178670-7	2016	Modulation of miR-135b or miR-146b expression by mimicking or inhibiting their expression regulated CaSR protein levels in two different colon cancer cell lines: Caco2/AQ (moderate endogenous CaSR expression) and HT29 (low endogenous CaSR levels).	caco2	162-167	microRNA 135b	Homo sapiens	14-22
26178670-7	2016	Modulation of miR-135b or miR-146b expression by mimicking or inhibiting their expression regulated CaSR protein levels in two different colon cancer cell lines: Caco2/AQ (moderate endogenous CaSR expression) and HT29 (low endogenous CaSR levels).	caco2	162-167	microRNA 146b	Homo sapiens	26-34
26432753-11	2016	P-gp inhibition increased [(3)H]alisertib uptake in Caco2 (P<.01) and MKN45 (P<.01) cells.	caco2	52-57	phosphoglycolate phosphatase	Homo sapiens	0-4
26270575-6	2015	RESULTS: DHA significantly attenuated IL-1beta induced proinflammatory IL-8 and IL-6 protein and mRNA in fetal H4, NEC-IEC, and mature Caco2, NCM460 IEC, compared to control and PAL treatment.	caco2	135-140	interleukin 1 beta	Homo sapiens	38-46
26817277-0	2015	The influence of passage number for Caco2 cell models when evaluating P-gp mediated drug transport.	caco2	36-41	phosphoglycolate phosphatase	Homo sapiens	70-74
26817277-3	2015	Our aim was to improve the Caco2 cell model for determination of P-glycoprotein mediated drug transport.	caco2	27-32	ATP binding cassette subfamily B member 1	Homo sapiens	65-79
26817277-4	2015	Young passage Caco2 from ATCC had inadequate expression of P-glycoprotein, therefore three approaches were adopted to upregulate Caco2 P-glycoprotein expression to mimic that in vivo; a) incubation of mature Caco2 monolayer with rifampicin, b) prolonged exposure of Caco2 cells to vinblastine (generating the Caco2 VIN line), and c) splitting cells every 7 to 9 days until late passage numbers (over P80) were available.	caco2	129-134	ATP binding cassette subfamily B member 1	Homo sapiens	135-149
26817277-4	2015	Young passage Caco2 from ATCC had inadequate expression of P-glycoprotein, therefore three approaches were adopted to upregulate Caco2 P-glycoprotein expression to mimic that in vivo; a) incubation of mature Caco2 monolayer with rifampicin, b) prolonged exposure of Caco2 cells to vinblastine (generating the Caco2 VIN line), and c) splitting cells every 7 to 9 days until late passage numbers (over P80) were available.	caco2	129-134	ATP binding cassette subfamily B member 1	Homo sapiens	135-149
26817277-4	2015	Young passage Caco2 from ATCC had inadequate expression of P-glycoprotein, therefore three approaches were adopted to upregulate Caco2 P-glycoprotein expression to mimic that in vivo; a) incubation of mature Caco2 monolayer with rifampicin, b) prolonged exposure of Caco2 cells to vinblastine (generating the Caco2 VIN line), and c) splitting cells every 7 to 9 days until late passage numbers (over P80) were available.	caco2	129-134	ATP binding cassette subfamily B member 1	Homo sapiens	135-149
26817277-9	2015	The highest basolateral to apical transport was observed for both passage 89 Caco2 and the Caco2 VIN model with an efflux ratio of 13 to 14.	caco2	91-96	long intergenic non-protein coding RNA 1191	Homo sapiens	97-100
26467114-5	2015	The supernatants of resting and IL-1beta-stimulated Caco2, HT-29 and SW-1116 colonic epithelial cells (CEC), cell lysates of CECs and tear samples of human healthy individuals were analyzed and the feasibility of the developed method was validated by ELISA and dot-blot analysis complemented by RT-qPCR.	caco2	52-57	interleukin 1 beta	Homo sapiens	32-40
26294673-6	2015	Application of recombinant GDNF on Caco2 and HT29B6 cells for 24 h resulted in significant epithelial barrier stabilization in monolayers with immature barrier functions.	caco2	35-40	glial cell derived neurotrophic factor	Homo sapiens	27-31
25790781-4	2015	RNAi method was used to inhibit the expression of FAK in Caco2 and SMMC-7721 cells.	caco2	57-62	protein tyrosine kinase 2	Homo sapiens	50-53
26284136-7	2015	Treatment with Nampt-siRNA reduced the Nampt protein expression resulting in the inhibition of the cell viability of HCT116 and Caco2.	caco2	128-133	nicotinamide phosphoribosyltransferase	Homo sapiens	15-20
26284136-7	2015	Treatment with Nampt-siRNA reduced the Nampt protein expression resulting in the inhibition of the cell viability of HCT116 and Caco2.	caco2	128-133	nicotinamide phosphoribosyltransferase	Homo sapiens	39-44
23873170-9	2014	The MSS-CHFR-unmethylated line, CACO2 , was resistant to single and combination therapy, while COLO205, the MSS/CHFR-methylated line, showed tumor growth inhibition with docetaxel, but not gemcitabine, therapy.	caco2	32-37	SIL1 nucleotide exchange factor	Homo sapiens	4-7
25861245-0	2015	TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells.	caco2	103-108	tumor necrosis factor	Homo sapiens	0-9
25861245-0	2015	TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells.	caco2	103-108	interleukin 6	Homo sapiens	14-18
25861245-0	2015	TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells.	caco2	103-108	apolipoprotein A4	Homo sapiens	27-46
25394657-5	2015	cIAP2 was induced in vitro in regenerating Caco2 IECs after wound infliction (P < 0.01).	caco2	43-48	baculoviral IAP repeat containing 3	Homo sapiens	0-5
25551765-5	2014	Fomiroid A inhibited ezetimibe glucuronide binding to NPC1L1, and dose-dependently prevented NPC1L1-mediated cholesterol uptake and formation of esterified cholesterol in NPC1L1-expressing Caco2 cells.	caco2	189-194	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	93-99
25551765-5	2014	Fomiroid A inhibited ezetimibe glucuronide binding to NPC1L1, and dose-dependently prevented NPC1L1-mediated cholesterol uptake and formation of esterified cholesterol in NPC1L1-expressing Caco2 cells.	caco2	189-194	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	93-99
24176760-4	2014	Therefore, in the current study we investigated the impact of 1,25D3, tumor necrosis factor alpha (TNFalpha), and interleukin (IL)-6 on CaSR expression in a differentiated (Caco2/AQ) and in a moderately differentiated (Coga1A) colon cancer cell line.	caco2	173-178	calcium sensing receptor	Homo sapiens	136-140
24770931-9	2014	ACSL5-related over-expression of mitochondrial mortalin was found in HEK293 and Lovo (wild-type TP53 [tumor protein p53]) and CaCo2 (p53-negative; TP53 mutated) cells but not in Colo320DM cells (mutated TP53).	caco2	126-131	acyl-CoA synthetase long chain family member 5	Homo sapiens	0-5
24399445-5	2014	Here, we found that the subcellular localization of several apical markers including dipeptidyl peptidase IV (DPPIV) was strikingly modified in Drebrin E-depleted Caco2 cells.	caco2	163-168	dipeptidyl peptidase 4	Homo sapiens	85-108
24659889-6	2014	Two colorectal cancer cells DLD-1 and Caco2 were used for KRAS inhibition.	caco2	38-43	KRAS proto-oncogene, GTPase	Homo sapiens	58-62
24659889-14	2014	In contrast, pro-angiogenic chemokines (CXCL1, CXCL8) showed a high constitutive expression in the mutated cell-lines DLD-1 (KRAS), HT-29 and Colo205 (BRAF), compared to wild type (Caco2).	caco2	181-186	C-X-C motif chemokine ligand 1	Homo sapiens	40-45
24659889-14	2014	In contrast, pro-angiogenic chemokines (CXCL1, CXCL8) showed a high constitutive expression in the mutated cell-lines DLD-1 (KRAS), HT-29 and Colo205 (BRAF), compared to wild type (Caco2).	caco2	181-186	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	151-155
24412598-6	2014	Epinephrine (Ep) treatment accelerated the FG-induced TNF-alpha production and TLR5 expression on the Caco2, but not RAW264 cells.	caco2	102-107	toll like receptor 5	Homo sapiens	79-83
24950815-0	2014	Somatostatin ameliorates lipopolysaccharide-induced tight junction damage via the ERK-MAPK pathway in Caco2 cells.	caco2	102-107	mitogen-activated protein kinase 1	Homo sapiens	82-85
24950815-0	2014	Somatostatin ameliorates lipopolysaccharide-induced tight junction damage via the ERK-MAPK pathway in Caco2 cells.	caco2	102-107	mitogen-activated protein kinase 3	Homo sapiens	86-90
24950815-8	2014	Furthermore, SST decreased the LPS-induced phosphorylation of ERK1/2, and a selective MEK inhibitor markedly protected the barrier function against LPS disturbance by blocking the activation of the ERK-MAPK pathway in Caco2 cells.	caco2	218-223	mitogen-activated protein kinase kinase 7	Homo sapiens	86-89
24950815-8	2014	Furthermore, SST decreased the LPS-induced phosphorylation of ERK1/2, and a selective MEK inhibitor markedly protected the barrier function against LPS disturbance by blocking the activation of the ERK-MAPK pathway in Caco2 cells.	caco2	218-223	mitogen-activated protein kinase 3	Homo sapiens	202-206
24892806-3	2014	Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disruption of apical and basolateral trafficking; however, no microvillus inclusions were observed in MYO5B-KD cells.	caco2	37-42	myosin VB	Homo sapiens	7-12
24892806-3	2014	Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disruption of apical and basolateral trafficking; however, no microvillus inclusions were observed in MYO5B-KD cells.	caco2	37-42	myosin VB	Homo sapiens	24-29
24892806-3	2014	Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disruption of apical and basolateral trafficking; however, no microvillus inclusions were observed in MYO5B-KD cells.	caco2	37-42	myosin VB	Homo sapiens	24-29
24399445-5	2014	Here, we found that the subcellular localization of several apical markers including dipeptidyl peptidase IV (DPPIV) was strikingly modified in Drebrin E-depleted Caco2 cells.	caco2	163-168	dipeptidyl peptidase 4	Homo sapiens	110-115
24399445-5	2014	Here, we found that the subcellular localization of several apical markers including dipeptidyl peptidase IV (DPPIV) was strikingly modified in Drebrin E-depleted Caco2 cells.	caco2	163-168	drebrin 1	Homo sapiens	144-153
24399445-9	2014	Consistent with this, the phenotype observed in Drebrin E knock-down Caco2 cells shares some features with a pathology called microvillar inclusion disease (MVID) involving both Myosin Vb and Rab8a.	caco2	69-74	drebrin 1	Homo sapiens	48-57
24399445-9	2014	Consistent with this, the phenotype observed in Drebrin E knock-down Caco2 cells shares some features with a pathology called microvillar inclusion disease (MVID) involving both Myosin Vb and Rab8a.	caco2	69-74	myosin VB	Homo sapiens	178-187
24399445-9	2014	Consistent with this, the phenotype observed in Drebrin E knock-down Caco2 cells shares some features with a pathology called microvillar inclusion disease (MVID) involving both Myosin Vb and Rab8a.	caco2	69-74	RAB8A, member RAS oncogene family	Homo sapiens	192-197
24399445-10	2014	Taken together, these results suggest that Drebrin E redirects the apical recycling pathway in intestinal epithelial cells to the lysosomes, demonstrating that Drebrin E is a key regulator in apical trafficking in Caco2 cells.	caco2	214-219	drebrin 1	Homo sapiens	43-52
24399445-10	2014	Taken together, these results suggest that Drebrin E redirects the apical recycling pathway in intestinal epithelial cells to the lysosomes, demonstrating that Drebrin E is a key regulator in apical trafficking in Caco2 cells.	caco2	214-219	drebrin 1	Homo sapiens	160-169
24068609-5	2014	All colon cancer cell lines (HCT 116, HT-29, C32, CaCo2, LoVo) were sensitive to 15 min insulin exposure with increased phosphorylation of Akt, PRAS40 and p70-S6K.	caco2	50-55	insulin	Homo sapiens	88-95
24068609-5	2014	All colon cancer cell lines (HCT 116, HT-29, C32, CaCo2, LoVo) were sensitive to 15 min insulin exposure with increased phosphorylation of Akt, PRAS40 and p70-S6K.	caco2	50-55	AKT serine/threonine kinase 1	Homo sapiens	139-142
25301365-9	2014	It is thus conceivable that beta-catenin may participate in the reported modulation of cytoskeletal dynamics in mAR stimulated Caco2 cells.	caco2	127-132	catenin beta 1	Homo sapiens	28-40
24473145-6	2014	More live H2O2-treated-caco2 cells were observed in pMSCs hypoxia culture medium (pMSCs-HCM) than pMSCs normoxia culture medium (pMSCs-NCM), and the application of a specific antibody that blocked insulin-like growth factor-1 (IGF-1) leads to a significant decrease of the protective effect of pMSCs-HCM.	caco2	23-28	insulin like growth factor 1	Homo sapiens	197-225
24473145-6	2014	More live H2O2-treated-caco2 cells were observed in pMSCs hypoxia culture medium (pMSCs-HCM) than pMSCs normoxia culture medium (pMSCs-NCM), and the application of a specific antibody that blocked insulin-like growth factor-1 (IGF-1) leads to a significant decrease of the protective effect of pMSCs-HCM.	caco2	23-28	insulin like growth factor 1	Homo sapiens	227-232
24473145-7	2014	Hypoxia can promote IGF-1 expression of pMSCs at mRNA and protein levels, and caco2 stably expressed IGF-1 receptor.	caco2	78-83	insulin like growth factor 1	Homo sapiens	101-106
24473145-8	2014	Knocking down IGF-1 expression in pMSCs by siRNA resulted in a significant attenuation of the increase in apoptosis of H2O2-treated-caco2 cultured in pMSCs-HCM.	caco2	132-137	insulin like growth factor 1	Homo sapiens	14-19
24005240-3	2013	We found that HCT116 cells highly express mitogen-activated protein kinase phosphatase-1 (MKP1), which selectively inactivates extracellular signal-regulated kinase (ERK), whereas MKP1 levels were undetectable in CaCo2 cells.	caco2	213-218	mitogen-activated protein kinase 1	Homo sapiens	166-169
23842475-4	2014	In extra-hepatic cells, Caco2, the activity of UGT1A9 proximal promoter increased to 73.4 +- 8.5% of that of the UGT1A8 proximal promoter with only 4 base changes: -160C, -152A, -62T, and -59G.	caco2	24-29	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	47-53
23842475-4	2014	In extra-hepatic cells, Caco2, the activity of UGT1A9 proximal promoter increased to 73.4 +- 8.5% of that of the UGT1A8 proximal promoter with only 4 base changes: -160C, -152A, -62T, and -59G.	caco2	24-29	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	113-119
24409057-9	2013	RESULTS: The X-ray radiation dose had a significant effect on the expression of miR-221 and PTEN protein in human Caco2 cells in a dose-dependent manner.	caco2	114-119	microRNA 221	Homo sapiens	80-87
24409057-9	2013	RESULTS: The X-ray radiation dose had a significant effect on the expression of miR-221 and PTEN protein in human Caco2 cells in a dose-dependent manner.	caco2	114-119	phosphatase and tensin homolog	Homo sapiens	92-96
23708747-8	2013	Expression of CD24 and CXCR4 appeared random in HT29 and Caco2.	caco2	57-62	CD24 molecule	Homo sapiens	14-18
24086361-2	2013	METHODS: Radioligand binding assays were performed to characterize the binding kinetics between [(125)I]-labeled ITF and IEC-6, HT-29, Caco2 and HaCaT cells.	caco2	135-140	trefoil factor 3	Rattus norvegicus	113-116
24086361-6	2013	The K i values for the interaction between IEC-6, HT-29, and Caco2 cells and non-labeled ITF were 20.98 +- 0.57 nM, 36.87 +- 3.35 nM, and 21.38 +- 0.93 nM, respectively, and the IC50 values were 25.21 +- 0.39 nM, 40.68 +- 0.27 nM, and 23.61 +- 0.25 nM, respectively.	caco2	61-66	trefoil factor 3	Homo sapiens	89-92
23751319-0	2013	Sulfated Astragalus polysaccharide can regulate the inflammatory reaction induced by LPS in Caco2 cells.	caco2	92-97	interferon regulatory factor 6	Homo sapiens	85-88
23751319-1	2013	This study evaluates the effect of sulfated Astragalus polysaccharide (SAPS) on inflammatory reaction induced by LPS in Caco2 cells.	caco2	120-125	interferon regulatory factor 6	Homo sapiens	113-116
23708747-8	2013	Expression of CD24 and CXCR4 appeared random in HT29 and Caco2.	caco2	57-62	C-X-C motif chemokine receptor 4	Homo sapiens	23-28
22714276-3	2012	We hypothesize that in vitro, the Caco2 model is associated with a constitutive neo-expression of the hematopoietic G-CSF thereby causing an autocrine stimulation of Caco2 growth and proliferation in vitro.	caco2	34-39	colony stimulating factor 3	Homo sapiens	116-121
23764899-3	2013	Transfection of hNMNAT2 resulted in a six- and threefold cytoplasmic overexpression in Caco2 and HT29 cell lines correlating with Tiazofurin-induced enhanced cell-kill.	caco2	87-92	nicotinamide nucleotide adenylyltransferase 2	Homo sapiens	16-23
23688995-6	2013	RESULTS: Transfection with anti-miR-221 caused a significant reduction in miR-221 expression (P<0.05) and up-regulated PTEN protein expression (P<0.05) in Caco2 cells.	caco2	161-166	microRNA 221	Homo sapiens	32-39
23688995-6	2013	RESULTS: Transfection with anti-miR-221 caused a significant reduction in miR-221 expression (P<0.05) and up-regulated PTEN protein expression (P<0.05) in Caco2 cells.	caco2	161-166	phosphatase and tensin homolog	Homo sapiens	122-126
23297381-7	2013	Small interfering RNA (siRNA) studies with Caco2-BBE cells showed a decrease in adherence of EPEC to Caco2 cells in which CD98 expression was knocked down.	caco2	43-48	solute carrier family 3 member 2	Homo sapiens	122-126
22940288-6	2013	Methyltransferase inhibitor 5-aza-2"-deoxycytidine (DAC) treatment resulted in an over 50-fold induction of CYP24A1 mRNA expression in Coga1A and HT-29 cells but in no response in Caco2/AQ and Coga13 cells.	caco2	180-185	arylacetamide deacetylase	Homo sapiens	52-55
23522334-0	2013	ANXA2 remodels the microstructures of caco2 cells.	caco2	38-43	annexin A2	Homo sapiens	0-5
23027178-11	2013	Finally, in vivo xenograft experiments demonstrated that CD66c silencing almost completely abrogated the tumorigenic potential of Caco2 cells.	caco2	130-135	CEA cell adhesion molecule 6	Homo sapiens	57-62
23469306-5	2013	METHODOLOGY/PRINCIPAL FINDINGS: We show here that E. histolytica activation of the classic TLR pathway in CaCo2 cells is required to induce beta defensin-2 (HBD2) mRNA expression and production of a 5-kDa cationic peptide with similar properties to the antimicrobial HBD2 expressed by CaCo2 cells exposed to enterotoxigenic Escherichia coli.	caco2	106-111	defensin beta 4A	Homo sapiens	140-155
23469306-5	2013	METHODOLOGY/PRINCIPAL FINDINGS: We show here that E. histolytica activation of the classic TLR pathway in CaCo2 cells is required to induce beta defensin-2 (HBD2) mRNA expression and production of a 5-kDa cationic peptide with similar properties to the antimicrobial HBD2 expressed by CaCo2 cells exposed to enterotoxigenic Escherichia coli.	caco2	106-111	defensin beta 4A	Homo sapiens	157-161
23469306-5	2013	METHODOLOGY/PRINCIPAL FINDINGS: We show here that E. histolytica activation of the classic TLR pathway in CaCo2 cells is required to induce beta defensin-2 (HBD2) mRNA expression and production of a 5-kDa cationic peptide with similar properties to the antimicrobial HBD2 expressed by CaCo2 cells exposed to enterotoxigenic Escherichia coli.	caco2	106-111	defensin beta 4A	Homo sapiens	267-271
22886548-6	2012	siRNA knockdown of SCC-S2 expression in CACO2 and HCT116 cells decrease cell proliferation, colony formation, and soft agar colony formation ability.	caco2	40-45	TNF alpha induced protein 8	Homo sapiens	19-25
22714276-3	2012	We hypothesize that in vitro, the Caco2 model is associated with a constitutive neo-expression of the hematopoietic G-CSF thereby causing an autocrine stimulation of Caco2 growth and proliferation in vitro.	caco2	166-171	colony stimulating factor 3	Homo sapiens	116-121
22817451-5	2012	The fully optimized process was used for the electrochemical detection of Caco2 cells in the presence of monocytes (THP-1), other circulating cells that could interfere in real blood samples.	caco2	74-79	GLI family zinc finger 2	Homo sapiens	116-121
22349148-4	2012	Knockdown of the cellular FK506-binding proteins FKBP1A and FKBP1B in CaCo2 cells prevented replication of HCoV-NL63, suggesting the requirement of these members of the immunophilin family for virus growth.	caco2	70-75	FKBP prolyl isomerase 1A	Homo sapiens	49-55
22493353-3	2012	MATERIALS AND METHODS: Expression of COM-1 was knocked out in the colorectal cancer cell lines RKO and CaCO2 by transfection with ribozyme transgenes which specifically targeted COM-1.	caco2	103-108	nuclear protein transcription regulator 1	Mus musculus	37-42
22573889-3	2012	In wounded monolayers of the intestinal epithelial cell line Caco2(BBe) (BBe), Myo9b localizes to the extreme leading edge of lamellipodia of migrating cells.	caco2	61-66	myosin IXB	Homo sapiens	79-84
22349148-4	2012	Knockdown of the cellular FK506-binding proteins FKBP1A and FKBP1B in CaCo2 cells prevented replication of HCoV-NL63, suggesting the requirement of these members of the immunophilin family for virus growth.	caco2	70-75	FKBP prolyl isomerase 1B	Homo sapiens	60-66
20599498-4	2010	Interestingly, overexpression of RGS19 stimulated the growth of HEK293, PC12, Caco2, and NIH3T3 cells.	caco2	78-83	regulator of G protein signaling 19	Homo sapiens	33-38
22149272-5	2012	SIRT1 overexpression induced PER1 upregulation in CaCo2 and downregulation in SW480 cells.	caco2	50-55	sirtuin 1	Homo sapiens	0-5
21723410-7	2011	siRNA-mediated suppression of NOX1 protein significantly inhibited E. histolytica-induced cell death and ROS response in Caco2 cells.	caco2	121-126	NADPH oxidase 1	Homo sapiens	30-34
21858054-9	2011	The synthesized poly P significantly induced HSP27 from Caco2/BBE cells.	caco2	56-61	heat shock protein family B (small) member 1	Homo sapiens	45-50
20884887-11	2010	DRA association with lipid rafts in the DI and LDF fractions of Caco2 cells was significantly enhanced (~45%) by NPY compared with control.	caco2	64-69	solute carrier family 26 member 3	Homo sapiens	0-3
20884887-11	2010	DRA association with lipid rafts in the DI and LDF fractions of Caco2 cells was significantly enhanced (~45%) by NPY compared with control.	caco2	64-69	neuropeptide Y	Homo sapiens	113-116
21046126-10	2011	CONCLUSIONS: Flavanols protect Caco2 cells against an induced oxidative stress and subsequent cellular death by reducing ROS production and preventing caspase-3 activation.	caco2	31-36	caspase 3	Homo sapiens	151-160
22393467-5	2011	CRNDE transcription start sites were identified in CaCo2 and HCT116 cells by 5"-RACE.	caco2	51-56	colorectal neoplasia differentially expressed	Homo sapiens	0-5
20397022-7	2010	In CaCo2 cells that express enzymatically active Cox-2 this activity is inhibited by ASA.	caco2	3-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-54
20977730-13	2010	During sodium butyrate-induced Caco2 cell differentiation, IGFBP-rP1 was upregulated and the expression showed significant correlation with the AKP activity.	caco2	31-36	insulin like growth factor binding protein 7	Homo sapiens	59-68
20558765-6	2010	We found that uptake of glycine-sarcosine, a specific substrate of PepT1, in intestinal epithelial Caco2-BBE cells was inhibited by Tri-DAP in a dose-dependent manner.	caco2	99-104	solute carrier family 15 member 1	Homo sapiens	67-72
20558765-6	2010	We found that uptake of glycine-sarcosine, a specific substrate of PepT1, in intestinal epithelial Caco2-BBE cells was inhibited by Tri-DAP in a dose-dependent manner.	caco2	99-104	death associated protein	Homo sapiens	136-139
20397022-12	2010	Pro-apoptotic bcl-2 family member, bad is down-regulated in cell lines HCT116 and CaCo2 by bortezomib treatment, a neoplasia-promoting event that is reversed by combination treatment.	caco2	82-87	BCL2 apoptosis regulator	Homo sapiens	14-19
20224006-6	2010	Application of Dsg2 ED to Caco2 monolayers resulted in increased cell dissociation compared with controls in a dispase-based enterocyte dissociation assay.	caco2	26-31	desmoglein 2	Homo sapiens	15-19
20334581-8	2010	According to confocal microscopy and Western Blotting, AICAR (1 mM), phenformin (1 mM) and A-769662 (10 microM) enhanced the SGLT1 protein abundance in the cell membrane of Caco2 cells suggesting that AMPK activity may increase membrane translocation of SGLT1.	caco2	173-178	solute carrier family 5 member 1	Homo sapiens	125-130
20334581-8	2010	According to confocal microscopy and Western Blotting, AICAR (1 mM), phenformin (1 mM) and A-769662 (10 microM) enhanced the SGLT1 protein abundance in the cell membrane of Caco2 cells suggesting that AMPK activity may increase membrane translocation of SGLT1.	caco2	173-178	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	201-205
20334581-8	2010	According to confocal microscopy and Western Blotting, AICAR (1 mM), phenformin (1 mM) and A-769662 (10 microM) enhanced the SGLT1 protein abundance in the cell membrane of Caco2 cells suggesting that AMPK activity may increase membrane translocation of SGLT1.	caco2	173-178	solute carrier family 5 member 1	Homo sapiens	254-259
20205943-8	2010	In a functional CaCo2 model, an increase in fls485 expression was paralleled by cellular maturation stage.	caco2	16-21	ssu-2 homolog	Homo sapiens	44-50