PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35360199-0	2022	IP-Se-06, a Selenylated Imidazo(1,2-a)pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1alpha and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells.	ip-se-06	0-8	AKT serine/threonine kinase 1	Homo sapiens	95-98
35360199-6	2022	At low concentration (1 muM), IP-Se-06 induced intracellular redox state modulation with depletion of TrxR and GSH levels as well as inhibition of NRF2 protein.	ip-se-06	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
35360199-0	2022	IP-Se-06, a Selenylated Imidazo(1,2-a)pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1alpha and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells.	ip-se-06	0-8	mechanistic target of rapamycin kinase	Homo sapiens	99-103
35360199-7	2022	IP-Se-06 also decreased mitochondrial membrane potential, induced cytochrome c release, and chromatin condensation.	ip-se-06	0-8	cytochrome c, somatic	Homo sapiens	66-78
35360199-0	2022	IP-Se-06, a Selenylated Imidazo(1,2-a)pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1alpha and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells.	ip-se-06	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
35360199-8	2022	Furthermore, IP-Se-06 induced apoptosis by decreasing levels of Bcl-xL while increasing levels of gamma-H2AX and p53 proteins.	ip-se-06	13-21	BCL2 like 1	Homo sapiens	64-70
35360199-8	2022	Furthermore, IP-Se-06 induced apoptosis by decreasing levels of Bcl-xL while increasing levels of gamma-H2AX and p53 proteins.	ip-se-06	13-21	tumor protein p53	Homo sapiens	113-116
35360199-9	2022	Treatment with IP-Se-06 induced cell cycle arrest and showed antiproliferative effect by inhibition of Akt/mTOR/HIF-1alpha and ERK 1/2 signaling pathways.	ip-se-06	15-23	AKT serine/threonine kinase 1	Homo sapiens	103-106
35360199-9	2022	Treatment with IP-Se-06 induced cell cycle arrest and showed antiproliferative effect by inhibition of Akt/mTOR/HIF-1alpha and ERK 1/2 signaling pathways.	ip-se-06	15-23	mechanistic target of rapamycin kinase	Homo sapiens	107-111
35360199-9	2022	Treatment with IP-Se-06 induced cell cycle arrest and showed antiproliferative effect by inhibition of Akt/mTOR/HIF-1alpha and ERK 1/2 signaling pathways.	ip-se-06	15-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
35360199-9	2022	Treatment with IP-Se-06 induced cell cycle arrest and showed antiproliferative effect by inhibition of Akt/mTOR/HIF-1alpha and ERK 1/2 signaling pathways.	ip-se-06	15-23	mitogen-activated protein kinase 3	Homo sapiens	127-134
35360199-10	2022	In addition, IP-Se-06 displayed significant inhibition of p38 MAPK and p-p38, leading to inhibition of inflammasome complex proteins (NLRP3 and caspase-1) in glioblastoma cells.	ip-se-06	13-21	mitogen-activated protein kinase 1	Homo sapiens	73-76
35360199-10	2022	In addition, IP-Se-06 displayed significant inhibition of p38 MAPK and p-p38, leading to inhibition of inflammasome complex proteins (NLRP3 and caspase-1) in glioblastoma cells.	ip-se-06	13-21	NLR family pyrin domain containing 3	Homo sapiens	134-139
35360199-10	2022	In addition, IP-Se-06 displayed significant inhibition of p38 MAPK and p-p38, leading to inhibition of inflammasome complex proteins (NLRP3 and caspase-1) in glioblastoma cells.	ip-se-06	13-21	caspase 1	Homo sapiens	144-153
33125183-6	2021	At nontoxic concentration, IP-Se-06 decreased the protein levels of Bcl-xL and increased the levels of p53, leading to inhibition of cell proliferation and apoptosis.	ip-se-06	27-35	BCL2 like 1	Homo sapiens	68-74
33125183-6	2021	At nontoxic concentration, IP-Se-06 decreased the protein levels of Bcl-xL and increased the levels of p53, leading to inhibition of cell proliferation and apoptosis.	ip-se-06	27-35	tumor protein p53	Homo sapiens	103-106