PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10648728-1	2000	In view of the substantial preclinical evidence that supports a seminal role of central corticotropin-releasing factor (CRF) neuronal systems in the physiology and pathophysiology of stress and anxiety, it is reasonable to suggest that the anxiolytic properties of benzodiazepines are mediated, at least in part, via regulation of CRFergic function.	Benzodiazepines	265-280	corticotropin releasing hormone	Homo sapiens	88-118
10671322-0	2000	Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer"s disease mutation is normalized with a benzodiazepine.	Benzodiazepines	133-147	presenilin 1	Mus musculus	61-73
11592053-0	2000	Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors.	Benzodiazepines	8-22	cholecystokinin A receptor	Homo sapiens	45-51
11592053-0	2000	Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors.	Benzodiazepines	8-22	cholecystokinin	Homo sapiens	45-48
10633493-0	2000	Overexpression of proenkephalin in the amygdala potentiates the anxiolytic effects of benzodiazepines.	Benzodiazepines	86-101	proenkephalin	Rattus norvegicus	18-31
10606840-6	2000	Both benzodiazepines induced a marked and long-lasting MLP amplitude decrease for 240 min with slow recovery over the following 360 min.	Benzodiazepines	5-20	cysteine and glycine rich protein 3	Homo sapiens	55-58
10606840-10	2000	While SLP changes were closely associated with sedation and high plasma benzodiazepine concentrations, MLP effects persisted for hours after sedation even at low benzodiazepine plasma levels.	Benzodiazepines	162-176	cysteine and glycine rich protein 3	Homo sapiens	103-106
10594919-4	2000	Whereas the mitochondrial benzodiazepine/diazepam binding inhibitor (DBI) receptor (MBR) was below the immunohistochemical detection limit in normal mice (except in the choroid plexus and ependyma cells), it was significantly expressed in many reactive astrocytes of jp and shi mice brains.	Benzodiazepines	26-40	diazepam binding inhibitor	Mus musculus	69-72
10602344-4	1999	In a first step to verify the physiological roles of mPer1 and mPer2 genes in the cerebellum, we examined the effects of benzodiazepines on the expression of the mPer1 and mPer2 genes.	Benzodiazepines	121-136	period circadian clock 1	Mus musculus	162-167
10683870-6	2000	After the synthesis, the fluorescent-labeled benzodiazepines were purified by HPLC, using an analytical RP-C18 column.	Benzodiazepines	45-60	RNA polymerase II, I and III subunit H	Homo sapiens	104-110
10602344-4	1999	In a first step to verify the physiological roles of mPer1 and mPer2 genes in the cerebellum, we examined the effects of benzodiazepines on the expression of the mPer1 and mPer2 genes.	Benzodiazepines	121-136	period circadian clock 2	Mus musculus	172-177
10602344-19	1999	Transient reductions of mPer1 mRNA levels by various benzodiazepines and tandospirone is associated with impairment of coordinated movement, such as rota-rod performance and equilibrium.	Benzodiazepines	53-68	period circadian clock 1	Mus musculus	24-29
10582800-0	1999	Preserved benzodiazepine receptors in Alzheimer"s disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF.	Benzodiazepines	10-24	RNA polymerase III subunit K	Homo sapiens	72-76
10665894-14	1999	Six additional subjects in the placebo group discontinued benzodiazepine therapy when given melatonin in period 2.	Benzodiazepines	58-72	period circadian regulator 2	Homo sapiens	105-113
10536013-3	1999	We now show that transgenic overexpression of the gamma3 subunit in gamma2 subunit-deficient mice restores benzodiazepine binding sites, benzodiazepine-modulated whole cell currents, and postsynaptic miniature currents, suggesting the formation of functional, postsynaptic receptors.	Benzodiazepines	107-121	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	68-74
10536013-3	1999	We now show that transgenic overexpression of the gamma3 subunit in gamma2 subunit-deficient mice restores benzodiazepine binding sites, benzodiazepine-modulated whole cell currents, and postsynaptic miniature currents, suggesting the formation of functional, postsynaptic receptors.	Benzodiazepines	137-151	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	68-74
10440734-3	1999	Anxiety-like behavior was reduced in both NCAM+/+ and NCAM-/- mice by systemic administration of the benzodiazepine agonist diazepam and the 5-HT1A receptor agonists buspirone and 8-OH-DPAT.	Benzodiazepines	101-115	neural cell adhesion molecule 1	Mus musculus	42-46
10501225-8	1999	From these observations, it is concluded that the corresponding residues on the alpha1 and beta2 subunits are involved more likely in the gating of the channel by GABA than in the binding of GABA or benzodiazepines.	Benzodiazepines	199-214	adrenoceptor alpha 1D	Homo sapiens	80-86
10501225-8	1999	From these observations, it is concluded that the corresponding residues on the alpha1 and beta2 subunits are involved more likely in the gating of the channel by GABA than in the binding of GABA or benzodiazepines.	Benzodiazepines	199-214	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	91-96
10583697-4	1999	BZPs are mainly catalysed by CYP3A4.	Benzodiazepines	0-4	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
10440734-3	1999	Anxiety-like behavior was reduced in both NCAM+/+ and NCAM-/- mice by systemic administration of the benzodiazepine agonist diazepam and the 5-HT1A receptor agonists buspirone and 8-OH-DPAT.	Benzodiazepines	101-115	neural cell adhesion molecule 1	Mus musculus	54-58
10224099-2	1999	The benzodiazepine binding site was characterized using a site-directed mutagenesis strategy in which amino acids of the alpha5 subunit were substituted by their corresponding alpha1 residues.	Benzodiazepines	4-18	adrenoceptor alpha 1D	Homo sapiens	176-182
10441393-0	1999	Benzodiazepine compounds as inhibitors of the src protein tyrosine kinase: screening of a combinatorial library of 1,4-benzodiazepines.	Benzodiazepines	0-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	46-49
10434001-1	1999	Alcohol-sensitive ANT rats have a point mutation in the cerebellum-enriched GABA(A) receptor alpha6 subunit, which makes this subunit and the ANT rats in vivo highly sensitive to benzodiazepine agonists.	Benzodiazepines	179-193	gamma-aminobutyric acid type A receptor subunit alpha6	Rattus norvegicus	76-107
10415698-1	1999	These results using herpes virus-mediated gene transfer to overexpress enkephalin in the amygdala support the role of amygdalar opioids in the anxiolytic actions of benzodiazepines and supraspinal nociception (see ref.	Benzodiazepines	165-180	proenkephalin	Rattus norvegicus	71-81
10235629-7	1999	Powerful and selective CCK2 receptor antagonits have been developed from a series of benzodiazepine compounds.	Benzodiazepines	85-99	cholecystokinin B receptor	Homo sapiens	23-36
10471171-7	1999	Fluoxetine also inhibits CYP3A and CYP2C19, increasing serum concentrations of some benzodiazepines.	Benzodiazepines	84-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30
10394992-1	1999	RATIONALE: Compounds varying in selectivity as 5-HT1A receptor antagonists have recently been reported to produce anxiolytic-like effects comparable to those of benzodiazepines in the mouse elevated plus-maze procedure.	Benzodiazepines	161-176	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	47-62
10357248-0	1999	Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress.	Benzodiazepines	31-45	carbonic anhydrase 3	Rattus norvegicus	87-90
10195555-5	1999	The symptoms of AWS can be controlled using the combination of a benzodiazepine (in Europe, also chlormethiazole) with haloperidol or clonidine.	Benzodiazepines	65-79	jagged canonical Notch ligand 1	Homo sapiens	16-19
10320829-0	1999	Differential involvement of adrenal and gonadal steroids in anterior and intermediate pituitary pro-opiomelanocortin mRNA expression induced by the endogenous benzodiazepine, octadecaneuropeptide, in adult male rats.	Benzodiazepines	159-173	proopiomelanocortin	Rattus norvegicus	96-116
10320829-0	1999	Differential involvement of adrenal and gonadal steroids in anterior and intermediate pituitary pro-opiomelanocortin mRNA expression induced by the endogenous benzodiazepine, octadecaneuropeptide, in adult male rats.	Benzodiazepines	159-173	diazepam binding inhibitor	Rattus norvegicus	175-195
10320829-1	1999	The involvement of the endogenous benzodiazepine, octadecaneuropeptide (ODN), in the regulation of proopiomelanocortin (POMC) mRNA expression at the pituitary level, and the influence of adrenal and gonadal steroids, have been studied using a quantitative in situ hybridization technique.	Benzodiazepines	34-48	proopiomelanocortin	Rattus norvegicus	99-118
10320829-1	1999	The involvement of the endogenous benzodiazepine, octadecaneuropeptide (ODN), in the regulation of proopiomelanocortin (POMC) mRNA expression at the pituitary level, and the influence of adrenal and gonadal steroids, have been studied using a quantitative in situ hybridization technique.	Benzodiazepines	34-48	proopiomelanocortin	Rattus norvegicus	120-124
10320829-9	1999	These studies indicate that, in vivo, the decrease in POMC mRNA expression in the anterior and intermediate pituitary induced by an endogenous benzodiazepine is differently modulated by adrenal and gonadal steroids, with a predominant influence of adrenal steroids at the anterior pituitary level and gonadal steroids at the intermediate pituitary level.	Benzodiazepines	143-157	proopiomelanocortin	Rattus norvegicus	54-58
10454206-7	1999	The benzodiazepine derivative NSC 664704 (7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one) was revealed by that approach as a moderately potent (IC50 0.4 microM) inhibitor of CDK2, which in initial experiments shows evidence of causing cell cycle redistribution in living cells.	Benzodiazepines	4-18	cyclin dependent kinase 2	Homo sapiens	177-181
10063485-1	1999	The benzodiazepines flunitrazepam, diazepam, and Ro 15-1788 and the beta-carboline DMCM bind with equivalent affinity to the benzodiazepine binding site of GABAA receptors containing different alpha subunits (i.e., alpha 1, alpha 2, alpha 3, or alpha 5); whereas, the triazolopyridazine CL 218,872 and imidazopyridine zolpidem have higher affinity for alpha 1 subunit-containing GABAA receptors.	Benzodiazepines	4-18	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	224-252
10051107-0	1999	Benzodiazepine tolerance at GABAergic synapses on hippocampal CA1 pyramidal cells.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	62-65
10051107-11	1999	Several pre- and postsynaptic changes at GABAergic synapses on CA1 pyramidal cells might be related to the decreased tonic GABA inhibition in FZP-treated CA1 neurons associated with the expression of benzodiazepine anticonvulsant tolerance.	Benzodiazepines	200-214	carbonic anhydrase 1	Rattus norvegicus	63-66
10051107-11	1999	Several pre- and postsynaptic changes at GABAergic synapses on CA1 pyramidal cells might be related to the decreased tonic GABA inhibition in FZP-treated CA1 neurons associated with the expression of benzodiazepine anticonvulsant tolerance.	Benzodiazepines	200-214	carbonic anhydrase 1	Rattus norvegicus	154-157
10063485-2	1999	In the present study, the in vivo binding of [3H]Ro 15-1788 in mouse cerebellum and spinal cord was used to establish the occupancy of the benzodiazepine binding site of GABAA receptors containing primarily alpha 1 and alpha 2/alpha 3 subunits, respectively.	Benzodiazepines	139-153	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	227-234
10218866-1	1999	The gamma subunit of the gamma-aminobutyric acid type A receptor (GABA(A)-R) is essential for bestowing both normal single channel conductance and sensitivity to benzodiazepines on native GABA(A)-Rs.	Benzodiazepines	162-177	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	66-75
9804365-0	1998	Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.	Benzodiazepines	15-29	colony stimulating factor 2	Homo sapiens	11-14
10336082-1	1999	The effect of prolonged benzodiazepine administration on GABA(A) receptor subunit (alpha1-6, beta1-3, gamma2) messenger RNAs was investigated in the rat hippocampus and cortex, among other brain areas.	Benzodiazepines	24-38	crystallin, gamma E	Rattus norvegicus	102-108
9808706-0	1998	Decreased benzodiazepine binding with little effect on gamma-aminobutyric acid binding in rat brain after treatment with antisense oligodeoxynucleotide to the gamma-aminobutyric acidA receptor gamma-2 subunit.	Benzodiazepines	10-24	gamma-aminobutyric acid type A receptor subunit gamma 2	Rattus norvegicus	159-200
9808706-1	1998	Benzodiazepine potentiation of gamma-aminobutyric acid (GABA) neurotransmission is associated with the presence of a gamma-2 subunit in the GABAA receptor.	Benzodiazepines	0-14	crystallin, gamma E	Rattus norvegicus	117-124
10101731-2	1999	Since PBR are decreased in animal models of stress and in patients with anxiety disorders, in the present study we analyze the ability of monocytes obtained from patients suffering from generalized anxiety to migrate towards chemoattracting benzodiazepines.	Benzodiazepines	241-256	translocator protein	Homo sapiens	6-9
9987027-1	1999	Benzodiazepine- and alcohol-induced ataxias in rodents have been proposed to be affected by the gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit, which contributes to receptors specifically expressed in cerebellar granule cells.	Benzodiazepines	0-14	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	144-151
9987027-9	1999	Diazepam-induced ataxia in alpha 6 -/- mice could be reversed by the benzodiazepine site antagonist flumazenil, indicating the involvement of the remaining alpha 1 beta 2/3 gamma 2 GABAA receptors of the granule cells.	Benzodiazepines	69-83	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	27-36
9987027-11	1999	We conclude that GABAA receptor alpha 6 subunit-dependent actions in the cerebellar cortex can be compensated by other receptor subtypes; but if not for the alpha 6 subunit, patients on benzodiazepine medication would suffer considerably from ataxic side-effects.	Benzodiazepines	186-200	gamma-aminobutyric acid type A receptor subunit alpha6	Homo sapiens	17-39
9987027-11	1999	We conclude that GABAA receptor alpha 6 subunit-dependent actions in the cerebellar cortex can be compensated by other receptor subtypes; but if not for the alpha 6 subunit, patients on benzodiazepine medication would suffer considerably from ataxic side-effects.	Benzodiazepines	186-200	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	32-39
10096472-1	1999	We investigated whether adenosine neuromodulation is involved in a benzodiazepine (midazolam)-induced depression of excitatory synaptic transmissions in the CA1 and dentate gyrus (DG) regions in rat hippocampal slices.	Benzodiazepines	67-81	carbonic anhydrase 1	Rattus norvegicus	157-160
10430468-0	1999	Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex.	Benzodiazepines	0-14	crystallin, gamma E	Rattus norvegicus	66-72
9827540-5	1998	L-735,821, a benzodiazepine molecule which inhibits the KCNQ1 channel activity (EC50 = 0.08 microM), also blocks KCNQ2 currents (EC50 = 1.5 microM).	Benzodiazepines	13-27	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	56-61
9757064-10	1998	However, the benzodiazepine agonist-insensitive subtype of [3H]Ro15-4513 binding activity, a pharmacological motif of alpha6 subunit-containing GABAA receptors, was lower in stg/stg mice relative to the +/+ strain which correlated with the lowered level of alpha6 subunit expression.	Benzodiazepines	13-27	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	118-124
9757064-10	1998	However, the benzodiazepine agonist-insensitive subtype of [3H]Ro15-4513 binding activity, a pharmacological motif of alpha6 subunit-containing GABAA receptors, was lower in stg/stg mice relative to the +/+ strain which correlated with the lowered level of alpha6 subunit expression.	Benzodiazepines	13-27	RIKEN cDNA 2300002M23 gene	Mus musculus	174-177
9757064-10	1998	However, the benzodiazepine agonist-insensitive subtype of [3H]Ro15-4513 binding activity, a pharmacological motif of alpha6 subunit-containing GABAA receptors, was lower in stg/stg mice relative to the +/+ strain which correlated with the lowered level of alpha6 subunit expression.	Benzodiazepines	13-27	RIKEN cDNA 2300002M23 gene	Mus musculus	178-181
9875680-6	1998	However, since changes in the pharmacogenetic metabolism of benzodiazepines and tricyclic and tetracyclic antidepressants are mainly governed by CYP2C19 and CYP2D6, caution is needed when used together with alcohol.	Benzodiazepines	60-75	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	145-152
9875680-6	1998	However, since changes in the pharmacogenetic metabolism of benzodiazepines and tricyclic and tetracyclic antidepressants are mainly governed by CYP2C19 and CYP2D6, caution is needed when used together with alcohol.	Benzodiazepines	60-75	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	157-163
9652349-0	1998	Regulation of GABA(A) receptor alpha1 protein is a sensitive indicator of benzodiazepine agonist efficacy.	Benzodiazepines	74-88	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	14-37
9754930-0	1998	Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands.	Benzodiazepines	104-118	adrenoceptor alpha 1D	Homo sapiens	30-36
9678645-13	1998	Further, BZD-treated E males exhibited decreased open and closed arm entries, spent significantly more time in the central area, and had lower CORT levels, another index of fear or stress, compared to BZD-treated PF and C males.	Benzodiazepines	9-12	cortistatin	Rattus norvegicus	143-147
9691927-2	1998	The aim of the present study was to evaluate the concentrations of endogenous benzodiazepines and the peptide, diazepam binding inhibitor, in the blood of patients with liver cirrhosis with and without overt encephalopathy, and to compare these levels with those of consumers of commercial benzodiazepines.	Benzodiazepines	290-305	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	111-137
9691927-9	1998	Serum levels of diazepam binding inhibitor tended to decrease when endogenous benzodiazepines levels increased.	Benzodiazepines	78-93	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	16-42
9716307-6	1998	It is also speculated that serotonin/benzodiazepine interactions existing in the brain may functionally involve the 5HT2C receptor subtypes and that the anxiogenic action reported under certain circumstances for 5HT mimetics are not mediated by 5HT2C receptor subtypes.	Benzodiazepines	37-51	5-hydroxytryptamine receptor 2C	Rattus norvegicus	116-121
9622252-12	1998	These results indicate that in vivo the endogenous benzodiazepine octadecaneuropeptide, via an activation of the benzodiazepine sites of the GABA(A) receptor, negatively modulates corticotropin-releasing hormone neuronal activity and that this modulation can be negatively or positively influenced by central and peripheral steroids.	Benzodiazepines	51-65	corticotropin releasing hormone	Rattus norvegicus	180-211
9678260-0	1998	The inhibitory effect of benzodiazepine derivatives on the bovine lens aldose reductase enzyme.	Benzodiazepines	25-39	aldose reductase	Bos taurus	71-87
9678260-3	1998	In this study, aldose reductase inhibitory activities of several benzodiazepine derivatives were investigated.	Benzodiazepines	65-79	aldose reductase	Bos taurus	15-31
9652349-1	1998	The effect of benzodiazepine agonists of varying efficacy on gamma-aminobutyric acidA receptor alpha1 subunit protein expression was determined in primary cultured cerebellar granule cells.	Benzodiazepines	14-28	adrenoceptor alpha 1D	Homo sapiens	95-101
9652349-3	1998	The grading of effect of the benzodiazepine partial agonists on alpha1 subunit protein expression is consistent with their agonist efficacies.	Benzodiazepines	29-43	adrenoceptor alpha 1D	Homo sapiens	64-70
9610920-0	1998	Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.	Benzodiazepines	66-80	5-hydroxytryptamine receptor 1A	Rattus norvegicus	41-47
9641612-7	1998	at -90 min), a benzodiazepine which binds to GABA receptors and possesses CRH-mediated inhibitory activity on HPA axis.	Benzodiazepines	15-29	corticotropin releasing hormone	Homo sapiens	74-77
9641612-14	1998	In conclusion, our present data demonstrate that the ACTH- and cortisol-releasing effect of HEX is abolished by either dexamethasone or alprazolam, a benzodiazepine, which is even able to blunt the GH-releasing activity of the hexapeptide.	Benzodiazepines	150-164	proopiomelanocortin	Homo sapiens	53-57
9610920-1	1998	The general purpose of the present study was to analyze the possible interactions between the GABA benzodiazepine and the serotonin systems in the mediation of the antianxiety actions of 5-HT1A compounds.	Benzodiazepines	99-113	5-hydroxytryptamine receptor 1A	Rattus norvegicus	187-193
9527511-10	1997	These studies demonstrate that the isoquinoline and benzodiazepine sites on the peripheral-type benzodiazepine receptor in human brain manifest many pharmacological characteristics that are distinct from each other and from rodent brain peripheral-type benzodiazepine receptors.	Benzodiazepines	52-66	translocator protein	Homo sapiens	80-119
9613098-8	1998	These results suggest that the changes in the levels of cerebral DBI induced by continuous treatments with alcohol and nicotine may be involved in the establishment of dependence by alcohol and nicotine, and such changes may be regulated by the benzodiazepine and nicotinic acetylcholine receptors, respectively.	Benzodiazepines	245-259	diazepam binding inhibitor	Mus musculus	65-68
9452937-0	1998	Locomotor and antidepressant-like effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed rats.	Benzodiazepines	86-100	5-hydroxytryptamine receptor 1A	Rattus norvegicus	45-52
9513081-1	1998	Diazepam-binding inhibitor (DBI) was initially isolated from the rat brain as a result of its ability to compete with benzodiazepines for their receptors.	Benzodiazepines	118-133	diazepam binding inhibitor	Rattus norvegicus	0-32
10461364-5	1998	In contrast, the benzodiazepine-derived CCK-BR ligand, YM022, acted as a "true" high-affinity antagonist of cholecystokinin-induced inositol phosphate formation (pA2 = 9.69).	Benzodiazepines	17-31	cholecystokinin B receptor	Homo sapiens	40-46
9579292-1	1998	Benzodiazepines have been reported to inhibit thyrotropin (TSH) and prolactin (PRL) secretion in response to stressful and pharmacologic stimuli in experimental animals.	Benzodiazepines	0-15	prolactin	Homo sapiens	68-77
9579292-9	1998	These preliminary results suggest that benzodiazepines, at therapeutic doses for the treatment of anxiety, may alter TRH-induced PRL release in humans.	Benzodiazepines	39-54	thyrotropin releasing hormone	Homo sapiens	117-120
9608607-0	1998	Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal.	Benzodiazepines	22-36	carbonic anhydrase 1	Rattus norvegicus	134-137
9608607-6	1998	Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn) is dramatically different from that of the classical benzodiazepine (BZD), diazepam (Valium, i.e., adinazolam increased, whereas diazepam decreased, 5-HT release within CA1 region of hippocampus in the freely moving and behaving rat.	Benzodiazepines	71-85	carbonic anhydrase 1	Rattus norvegicus	285-288
9608607-6	1998	Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn) is dramatically different from that of the classical benzodiazepine (BZD), diazepam (Valium, i.e., adinazolam increased, whereas diazepam decreased, 5-HT release within CA1 region of hippocampus in the freely moving and behaving rat.	Benzodiazepines	88-91	carbonic anhydrase 1	Rattus norvegicus	285-288
9342241-0	1997	Two-dimensional 1H-NMR and CD structural analysis in a micellar medium of a bovine alphaS1-casein fragment having benzodiazepine-like properties.	Benzodiazepines	114-128	casein alpha s1	Bos taurus	83-97
9435993-20	1997	CYP2C19 and CYP1A2, the metabolism of several benzodiazepines, including alprazolam, bromazepam and diazepam.	Benzodiazepines	46-61	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
9435993-20	1997	CYP2C19 and CYP1A2, the metabolism of several benzodiazepines, including alprazolam, bromazepam and diazepam.	Benzodiazepines	46-61	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
9342241-1	1997	The conformation of the benzodiazepine-like decapeptide, YLGYLEQLLR, corresponding to residues 91-100 of bovine alphaS1-casein, has been examined in SDS micelles using CD, two-dimensional 1H-NMR and restrained molecular-dynamics simulation.	Benzodiazepines	24-38	casein alpha s1	Bos taurus	112-126
9171317-2	1997	The benzodiazepine agonist clonazepam was demonstrated to depress the CA1 population spike.	Benzodiazepines	4-18	carbonic anhydrase 1	Rattus norvegicus	70-73
9238062-0	1997	A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity.	Benzodiazepines	102-116	tryptophanyl-tRNA synthetase 1	Homo sapiens	24-30
9378234-3	1997	A second class of benzodiazepine binding sites is found in virtually all mammalian peripheral tissues and is therefore called the peripheral type benzodiazepine receptor (PBR).	Benzodiazepines	18-32	translocator protein	Homo sapiens	171-174
9377101-0	1997	Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with modified benzodiazepine skeletons.	Benzodiazepines	115-129	gastrin	Rattus norvegicus	72-79
9272753-9	1997	The increase in punished responding produced by NPY was not altered by administration of the benzodiazepine antagonist flumazenil and only partially blocked by the picrotoxinin receptor ligand isopropylbicyclophosphate (10 and 15 microg/kg).	Benzodiazepines	93-107	neuropeptide Y	Homo sapiens	48-51
9194048-13	1997	The electrophysiological and behavioral profiles of NPY and the Y1 agonist resembles those of anxiolytics such as ethanol and benzodiazepines.	Benzodiazepines	126-141	neuropeptide Y	Homo sapiens	52-55
9128832-1	1997	Biochemical and electrophysiological approaches were used to assess possible changes in 5-HT1A receptors in the rat brain after long-term treatment with an anxiolytic benzodiazepine.	Benzodiazepines	167-181	5-hydroxytryptamine receptor 1A	Rattus norvegicus	88-94
9225310-0	1997	Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands.	Benzodiazepines	103-117	carbonic anhydrase 1	Mus musculus	40-43
9087523-1	1997	Labeling of the two more important gamma-aminobutyric acidA (GABA(A)) supramolecular sites with [3H] muscimol (GABA(A)) and [3H] flunitrazepam (benzodiazepine) provided saturable, stable, and dimorphic binding activities in cortical and limbic regions of the wood mouse Apodemus sylvaticus.	Benzodiazepines	144-158	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	35-68
9087523-1	1997	Labeling of the two more important gamma-aminobutyric acidA (GABA(A)) supramolecular sites with [3H] muscimol (GABA(A)) and [3H] flunitrazepam (benzodiazepine) provided saturable, stable, and dimorphic binding activities in cortical and limbic regions of the wood mouse Apodemus sylvaticus.	Benzodiazepines	144-158	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	61-68
9115236-0	1997	Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site.	Benzodiazepines	137-151	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	71-76
9145922-10	1997	These data suggest that Tyr159 and Tyr209 of the alpha1 subunit may be components of the BZ-binding site on alpha1 beta2 gamma2 GABA(A) receptors.	Benzodiazepines	89-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	115-120
9098698-1	1997	Diazepam-binding inhibitor has been initially isolated from the rat brain from its ability to compete with benzodiazepines for their receptors.	Benzodiazepines	107-122	diazepam binding inhibitor	Rattus norvegicus	0-26
9075704-4	1997	Using this more sensitive system, we show that native mouse TRH-Rs exhibit agonist-independent signaling activity that is directly proportional to the number of receptors expressed in COS-1 cells and is inhibited by negative antagonist benzodiazepine drugs.	Benzodiazepines	236-250	thyrotropin releasing hormone	Mus musculus	60-63
8922750-20	1996	At low concentrations, Sev enhances GABA-gated chloride current at a binding site independent of the allosteric modulator sites of barbiturates, benzodiazepines or neurosteroids.	Benzodiazepines	145-160	kallikrein 1-related peptidase C9	Rattus norvegicus	23-26
9329179-4	1997	Protein binding studies with human serum albumin (HSA, the main benzodiazepine carrier in human plasma) immobilized on a silica stationary phase revealed that HSA also preferentially binds one stereoisomer of 7.	Benzodiazepines	64-78	albumin	Homo sapiens	50-53
9329179-4	1997	Protein binding studies with human serum albumin (HSA, the main benzodiazepine carrier in human plasma) immobilized on a silica stationary phase revealed that HSA also preferentially binds one stereoisomer of 7.	Benzodiazepines	64-78	albumin	Homo sapiens	159-162
9329179-5	1997	However, both on line CD detection and stereospecific interaction with other common drugs clearly demonstrated that the stereoselectivity of immobilized HSA for 7 is opposite to that for all the other studied benzodiazepines.	Benzodiazepines	209-224	albumin	Homo sapiens	153-156
9409087-1	1997	Monoamine Oxidase (MAO) and the peripheral benzodiazepine binding site (PBR) share a close physical proximity to each other in the outer mitochondrial membrane.	Benzodiazepines	43-57	resistance to Paracoccidioides brasiliensis	Mus musculus	72-75
9409087-2	1997	Furthermore, MAO activity and the density of PBR sites are affected by stress; benzodiazepines may influence stress-induced changes in MAO activity.	Benzodiazepines	79-94	resistance to Paracoccidioides brasiliensis	Mus musculus	45-48
9117387-1	1996	We have studied the effects of the neuroleptic haloperidol and the non-benzodiazepine anxiolytics buspirone and lesopitron on the expression of c-Fos immunoreactivity in the rat forebrain.	Benzodiazepines	71-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	144-149
8972548-4	1996	In contrast, progesterone (1 mg/kg, for 9 days) produced a significant antistress effect, which was blocked by GABA-A antagonists picrotoxin (1 mg/kg) and bicuculline (1 mg/kg), but not by flumazenil (2 mg/kg), a specific benzodiazepine (BZD) antagonist.	Benzodiazepines	222-236	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	111-117
8972548-4	1996	In contrast, progesterone (1 mg/kg, for 9 days) produced a significant antistress effect, which was blocked by GABA-A antagonists picrotoxin (1 mg/kg) and bicuculline (1 mg/kg), but not by flumazenil (2 mg/kg), a specific benzodiazepine (BZD) antagonist.	Benzodiazepines	238-241	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	111-117
8889678-1	1996	An automated high-performance liquid chromatographic method, benzodiazepines by REMEDi HS, was used to analyze benzodiazepines and their metabolites after beta-glucuronidase hydrolysis of 1-mL urine specimens from the following: 924 clinic and hospital patients whose specimens had previously been found to be presumptively positive using either EMIT or Triage immunoassay methodologies and 128 individuals whose specimens had screened negative by EMIT d.a.u.TM.	Benzodiazepines	61-76	glucuronidase beta	Homo sapiens	155-173
8944400-1	1996	The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures.	Benzodiazepines	137-151	protein tyrosine kinase 2 beta	Homo sapiens	69-72
8944400-11	1996	The apparent pA2 and pKB values obtained in the present review were similar across behavioral assays, except that, in squirrel monkeys, flumazenil pKB values for antagonism of benzodiazepine-induced decreases in schedule-controlled behavior were lower than pKB values obtained from drug discrimination studies.	Benzodiazepines	176-190	protein tyrosine kinase 2 beta	Homo sapiens	147-150
8944400-11	1996	The apparent pA2 and pKB values obtained in the present review were similar across behavioral assays, except that, in squirrel monkeys, flumazenil pKB values for antagonism of benzodiazepine-induced decreases in schedule-controlled behavior were lower than pKB values obtained from drug discrimination studies.	Benzodiazepines	176-190	protein tyrosine kinase 2 beta	Homo sapiens	147-150
9196557-2	1996	Acute BDZ treatments were shown not only to suppress cell proliferation in rat thymus but also to decrease TNF-alpha, IL-1 and IL-6 release from adult mouse macrophages.	Benzodiazepines	6-9	tumor necrosis factor	Rattus norvegicus	107-116
9196557-2	1996	Acute BDZ treatments were shown not only to suppress cell proliferation in rat thymus but also to decrease TNF-alpha, IL-1 and IL-6 release from adult mouse macrophages.	Benzodiazepines	6-9	interleukin 6	Rattus norvegicus	127-131
8889678-1	1996	An automated high-performance liquid chromatographic method, benzodiazepines by REMEDi HS, was used to analyze benzodiazepines and their metabolites after beta-glucuronidase hydrolysis of 1-mL urine specimens from the following: 924 clinic and hospital patients whose specimens had previously been found to be presumptively positive using either EMIT or Triage immunoassay methodologies and 128 individuals whose specimens had screened negative by EMIT d.a.u.TM.	Benzodiazepines	111-126	glucuronidase beta	Homo sapiens	155-173
8819488-0	1996	Effects of benzodiazepine agonist exposure on corticotropin-releasing factor content and hormonal stress responses: divergent responses in male and ovariectomized female rats.	Benzodiazepines	11-25	corticotropin releasing hormone	Rattus norvegicus	46-76
8819488-1	1996	Benzodiazepine agonists affect endocrine responses of the hypothalamic-pituitary-adrenal axis and can antagonize many of the actions of corticotropin-releasing factor (CRF).	Benzodiazepines	0-14	corticotropin releasing hormone	Rattus norvegicus	136-166
8883570-2	1996	Most of the subjects (84% of cases and 89% of controls) improved on ECT, but the benzodiazepine group of patients receiving unilateral ECT showed a significantly poorer response and a longer stay in hospital.	Benzodiazepines	81-95	ECT	Homo sapiens	135-138
8883570-4	1996	It is therefore concluded that prescription of benzodiazepines with ECT does compromise the therapeutic effect of unilateral ECT for depression.	Benzodiazepines	47-62	ECT	Homo sapiens	125-128
8818332-0	1996	Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor alpha 1 subunit protein in rat cerebellar granule cells.	Benzodiazepines	24-38	gamma-aminobutyric acid type A receptor subunit alpha 1	Rattus norvegicus	66-88
8872994-2	1996	In this study, the effects of anesthesia on the modulation of the GABAA receptor complex by ethanol, a benzodiazepine, and a barbiturate were determined.	Benzodiazepines	103-117	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	66-71
8818332-2	1996	Chronic benzodiazepine treatment of rat cerebellar granule cells induced a transient down-regulation of the gamma-aminobutyric acidA (GABAA) receptor alpha 1 subunit protein, that was dose-dependent (1 nM-1 microM) and prevented by the benzodiazepine antagonist flumazenil (1 microM).	Benzodiazepines	8-22	gamma-aminobutyric acid type A receptor subunit alpha 1	Rattus norvegicus	108-157
8818332-2	1996	Chronic benzodiazepine treatment of rat cerebellar granule cells induced a transient down-regulation of the gamma-aminobutyric acidA (GABAA) receptor alpha 1 subunit protein, that was dose-dependent (1 nM-1 microM) and prevented by the benzodiazepine antagonist flumazenil (1 microM).	Benzodiazepines	236-250	gamma-aminobutyric acid type A receptor subunit alpha 1	Rattus norvegicus	108-157
8723715-8	1996	The distributional patterns obtained for the alpha 1 and alpha 2 subunits suggest that striatal efferent neurons directly influence pallidal neurons displaying a distinct GABAA subunit composition, which may be of pharmacological importance since the alpha 1 beta x gamma 2-subunits containing receptors have mainly a benzodiazepine type I pharmacology.	Benzodiazepines	318-332	adrenoceptor alpha 1D	Homo sapiens	45-64
8698625-4	1996	Among several antagonists, a benzodiazepine derivative, YM022 had the most potent activities in competing with [125I]CCK-8 or [125I]gastrin I binding, inhibition of CCK-8- or gastrin I-induced phosphoinositide hydrolysis and increasing cytoplasmic free calcium.	Benzodiazepines	29-43	gastrin	Homo sapiens	132-139
8698625-4	1996	Among several antagonists, a benzodiazepine derivative, YM022 had the most potent activities in competing with [125I]CCK-8 or [125I]gastrin I binding, inhibition of CCK-8- or gastrin I-induced phosphoinositide hydrolysis and increasing cytoplasmic free calcium.	Benzodiazepines	29-43	gastrin	Homo sapiens	175-182
8723715-8	1996	The distributional patterns obtained for the alpha 1 and alpha 2 subunits suggest that striatal efferent neurons directly influence pallidal neurons displaying a distinct GABAA subunit composition, which may be of pharmacological importance since the alpha 1 beta x gamma 2-subunits containing receptors have mainly a benzodiazepine type I pharmacology.	Benzodiazepines	318-332	adrenoceptor alpha 1D	Homo sapiens	45-52
18966526-2	1996	The sparc models proved to be suitable for estimating the pK(a) values of beta-adrenergic blocking agents and benzodiazepine drugs.	Benzodiazepines	110-124	secreted protein acidic and cysteine rich	Homo sapiens	4-9
8633088-1	1996	Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to reverse the transformed morphology of Rat1 cells expressing oncogenic H-RasV12.	Benzodiazepines	0-14	HRas proto-oncogene, GTPase	Rattus norvegicus	115-120
8610817-8	1996	Cytochrome P450 3A4 metabolizes terfenadine, astemizole, carbamazepine, alprazolam, triazolam, and other benzodiazepines.	Benzodiazepines	105-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
8882620-20	1996	The differences in the benzodiazepine pharmacology of RDL homo-oligomers and native GABA receptors, may reflect roles of other subunits in native insect receptors.	Benzodiazepines	23-37	Resistant to dieldrin	Drosophila melanogaster	54-57
8822037-5	1996	Spectrophotometric measurements of redox states of rat skeletal muscle mitochondria cytochromes show a decrease in the reduction of aa3 and c+c1 cytochromes in the presence of the benzodiazepine.	Benzodiazepines	180-194	Cardiac cell morphology QTL 1	Rattus norvegicus	140-144
8773406-3	1996	PK 11195, an antagonist of the peripheral-type benzodiazepine receptor, counteracted the effect of the benzodiazepines, but had no effect on the increase in free cytosolic calcium evoked by the elevated [K+]0.	Benzodiazepines	103-118	translocator protein	Homo sapiens	31-70
8592140-0	1996	The alpha 1 and alpha 6 subunits can coexist in the same cerebellar GABAA receptor maintaining their individual benzodiazepine-binding specificities.	Benzodiazepines	112-126	adrenoceptor alpha 1D	Homo sapiens	4-23
8592140-1	1996	Two GABAA receptor subunit-specific antibodies anti-alpha 6 and anti-alpha 1 have been used for elucidating the relationship between the presence of alpha 1 and/or alpha 6 subunits in the cerebellar GABAA receptors and the benzodiazepine-binding specificity.	Benzodiazepines	223-237	adrenoceptor alpha 1D	Homo sapiens	69-76
8592140-1	1996	Two GABAA receptor subunit-specific antibodies anti-alpha 6 and anti-alpha 1 have been used for elucidating the relationship between the presence of alpha 1 and/or alpha 6 subunits in the cerebellar GABAA receptors and the benzodiazepine-binding specificity.	Benzodiazepines	223-237	adrenoceptor alpha 1D	Homo sapiens	149-171
8592140-5	1996	The results also show that receptors where alpha 1 and alpha 6 subunits coexist have two pharmacologically different benzodiazepine-binding properties, each associated with a different alpha subunit.	Benzodiazepines	117-131	adrenoceptor alpha 1D	Homo sapiens	43-62
8749980-7	1995	Most favored antidepressants, usually tricyclic, for agoraphobia, panic and OCD; beta-blockers for specific social phobia; and benzodiazepines for GAD and adjustment disorder.	Benzodiazepines	127-142	glutamate decarboxylase 1	Homo sapiens	147-150
8742044-0	1996	A benzodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after footshocks but not osmotic stimulus in the rat.	Benzodiazepines	2-16	arginine vasopressin	Rattus norvegicus	43-54
8742044-4	1996	It is thus possible that benzodiazepines suppress vasopressin and oxytocin release after noxious stimuli.	Benzodiazepines	25-40	arginine vasopressin	Rattus norvegicus	50-61
8788494-1	1996	The discovery that non-benzodiazepine anxiolytic agents such as buspirone bind with high affinity to the 5-HT1A receptor has stimulated the development of selective 5-HT1A receptor ligands as potential drug candidates.	Benzodiazepines	23-37	5-hydroxytryptamine receptor 1A	Homo sapiens	105-120
8549036-1	1996	BACKGROUND: Midazolam is a short-acting benzodiazepine that is metabolized by CYP3A enzymes.	Benzodiazepines	40-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-83
8594301-10	1996	Taken together, these findings suggest that the specific binding of PAF receptor antagonists WEB 2086 and BN 50739 in rat hepatocytes does not involve PAF receptors and occurs via peripheral benzodiazepine and, possibly GABA(A) receptor sites.	Benzodiazepines	191-205	platelet-activating factor receptor	Rattus norvegicus	68-80
9014159-1	1996	The gamma 2 subunit is necessary for the expression of the full benzodiazepine pharmacology of GABAA receptors and is one of the major subunits in the brain.	Benzodiazepines	64-78	tryptophanyl-tRNA synthetase 1	Homo sapiens	4-11
8843497-6	1996	On the other hand, the three groups (elderly subjects, subjects faced with unresolved stress, and BZ consumers) show increase of the CD57 lymphocyte subset as well as natural killer cytotoxicity.	Benzodiazepines	98-100	beta-1,3-glucuronyltransferase 1	Homo sapiens	133-137
8748427-4	1995	However, the cytochrome P450 3A subfamily and the 3A3 and 3A4 isoforms (CYP3A3/4) in particular are becoming increasingly important in psychopharmacology as a result of their central involvement in the metabolism of a wide range of steroids and medications, including antidepressants, benzodiazepines, calcium channel blockers, and carbamazepine.	Benzodiazepines	285-300	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-80
8719414-5	1995	Both the EC50 and efficacy of benzodiazepine site ligands were influenced by the type of gamma subunit coexpressed with alpha 1 and beta 2.	Benzodiazepines	30-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	81-138
8719432-1	1995	The GABAA (gamma-aminobutyric acid-A) receptor gamma 2 subunit subtype is probably a functionally integral part of the benzodiazepine binding site of the GABAA receptor complex, important for benzodiazepine pharmacology.	Benzodiazepines	119-133	gamma-aminobutyric acid type A receptor subunit gamma 2	Rattus norvegicus	11-54
8719432-1	1995	The GABAA (gamma-aminobutyric acid-A) receptor gamma 2 subunit subtype is probably a functionally integral part of the benzodiazepine binding site of the GABAA receptor complex, important for benzodiazepine pharmacology.	Benzodiazepines	192-206	gamma-aminobutyric acid type A receptor subunit gamma 2	Rattus norvegicus	11-54
8748046-3	1995	Our previous studies revealed the ability of flumazenil (a benzodiazepine antagonist) to counteract GHB effects on GH secretion.	Benzodiazepines	59-73	growth hormone 1	Homo sapiens	100-102
7641409-0	1995	Benzodiazepines attenuate the pituitary-adrenal responses to corticotrophin-releasing hormone in healthy volunteers, but not in patients with Cushing"s syndrome.	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	61-93
8557845-3	1995	In heterologous expression systems, functional receptors require a combination of alpha-, beta-, and gamma-subunit variants, the gamma 2-subunit being essential to convey a classical benzodiazepine site to the receptor.	Benzodiazepines	183-197	crystallin, gamma E	Rattus norvegicus	129-136
8838677-1	1995	The binding of warfarin, a series of non-steroidal anti-inflammatory drugs and a series of benzodiazepines to rat serum albumin (RatSA) and rabbit serum albumin (RabSA) was compared with their binding to human serum albumin (HSA) using high-performance liquid chromatography on stationary phases based on immobilized albumins.	Benzodiazepines	91-106	albumin	Homo sapiens	114-127
8838677-1	1995	The binding of warfarin, a series of non-steroidal anti-inflammatory drugs and a series of benzodiazepines to rat serum albumin (RatSA) and rabbit serum albumin (RabSA) was compared with their binding to human serum albumin (HSA) using high-performance liquid chromatography on stationary phases based on immobilized albumins.	Benzodiazepines	91-106	albumin	Homo sapiens	147-160
8838677-1	1995	The binding of warfarin, a series of non-steroidal anti-inflammatory drugs and a series of benzodiazepines to rat serum albumin (RatSA) and rabbit serum albumin (RabSA) was compared with their binding to human serum albumin (HSA) using high-performance liquid chromatography on stationary phases based on immobilized albumins.	Benzodiazepines	91-106	albumin	Homo sapiens	147-160
8519435-1	1995	The reported ability of benzodiazepines to increase human erythrocyte aldehyde dehydrogenase (ALDH) activity and reverse the disulfiram-induced inhibition of ALDH was reexamined.	Benzodiazepines	24-39	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	94-98
8519435-1	1995	The reported ability of benzodiazepines to increase human erythrocyte aldehyde dehydrogenase (ALDH) activity and reverse the disulfiram-induced inhibition of ALDH was reexamined.	Benzodiazepines	24-39	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	158-162
7644489-0	1995	Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.	Benzodiazepines	0-14	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	96-126
7644489-1	1995	Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors.	Benzodiazepines	96-110	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	124-154
7644489-1	1995	Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors.	Benzodiazepines	96-110	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	156-161
7644489-1	1995	Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors.	Benzodiazepines	112-114	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	124-154
7644489-1	1995	Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors.	Benzodiazepines	112-114	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	156-161
7644489-12	1995	The lack of postnatal GABAA receptor regulation by endogenous ligands of BZ sites might contribute to this phenotype.	Benzodiazepines	73-75	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	22-27
7641409-4	1995	We have therefore evaluated the effects of a benzodiazepine drug on the pituitary-adrenal response to CRH.	Benzodiazepines	45-59	corticotropin releasing hormone	Homo sapiens	102-105
7883836-1	1995	Alprazolam, a benzodiazepine derivative, stimulates specific gamma-aminobutyric acidA receptors and has been found to inhibit CRH activity in the brain.	Benzodiazepines	14-28	corticotropin releasing hormone	Homo sapiens	126-129
7637878-1	1995	Oral administration of the benzodiazepine, flurazepam, for one week results in tolerance in vivo and in vitro and in a reduction in recurrent and feedforward inhibition in vitro in the CA1 pyramidal cell region of hippocampus.	Benzodiazepines	27-41	carbonic anhydrase 1	Rattus norvegicus	185-188
7637878-13	1995	Overall, the findings indicate an impairment of transmission at GABAergic synapses onto hippocampal CA1 pyramidal cell neurons after chronic benzodiazepine treatment at a time when rats are tolerant to the anticonvulsant effects of the benzodiazepines in vivo.	Benzodiazepines	141-155	carbonic anhydrase 1	Rattus norvegicus	100-103
7637878-13	1995	Overall, the findings indicate an impairment of transmission at GABAergic synapses onto hippocampal CA1 pyramidal cell neurons after chronic benzodiazepine treatment at a time when rats are tolerant to the anticonvulsant effects of the benzodiazepines in vivo.	Benzodiazepines	236-251	carbonic anhydrase 1	Rattus norvegicus	100-103
7768013-0	1995	Effect of beta-glucuronidase on urinary benzodiazepine concentrations determined by fluorescence polarization immunoassay.	Benzodiazepines	40-54	glucuronidase beta	Homo sapiens	10-28
7768013-1	1995	In samples from patients treated with oxazepam, beta-glucuronidase increased the immunoreactivity of urinary benzodiazepines analyzed by fluorescence polarization immunoassay (FPIA).	Benzodiazepines	109-124	glucuronidase beta	Homo sapiens	48-66
7768013-6	1995	Thus, beta-glucuronidase can be used to increase the sensitivity of the urinary benzodiazepine FPIA without reducing the specificity of the method.	Benzodiazepines	80-94	glucuronidase beta	Homo sapiens	6-24
7655304-0	1995	Relationships between binding of benzodiazepines to alpha-1-acid glycoprotein and human serum albumin and their retention on the protein and octadecylsilane columns.	Benzodiazepines	33-48	albumin	Homo sapiens	88-101
7655304-1	1995	Correlation between binding parameters of 6 benzodiazepines to free human serum albumin (HSA) and chromatographic retention parameters on the HSA stationary phase (HSA-SP) was better than the similar correlation with alpha-1-acid glycoprotein (AGP).	Benzodiazepines	44-59	albumin	Homo sapiens	74-87
7780638-5	1995	DMCM at low concentrations (< 0.5 microM) occupying only the benzodiazepine site decreased GABA-induced Cl currents in the alpha 1 beta 2 gamma 2 and alpha 3 beta 2 gamma 2 subtypes as expected from an inverse agonist, but produced no change in the alpha 6 beta 2 gamma 2 subtype (perhaps a neutral antagonist).	Benzodiazepines	64-78	adrenoceptor alpha 1D	Homo sapiens	126-148
7716133-3	1995	In the present study we simultaneously examined the effects of the newly developed benzodiazepine derivative FK480 and proglumide-related antagonist KSG-504 on CCK octapeptide (CCK-8)-stimulated exocrine and endocrine function in the isolated perfused rat pancreas.	Benzodiazepines	83-97	cholecystokinin	Rattus norvegicus	160-163
7716133-3	1995	In the present study we simultaneously examined the effects of the newly developed benzodiazepine derivative FK480 and proglumide-related antagonist KSG-504 on CCK octapeptide (CCK-8)-stimulated exocrine and endocrine function in the isolated perfused rat pancreas.	Benzodiazepines	83-97	cholecystokinin	Rattus norvegicus	177-180
7777197-4	1995	Co-expression of the mutants with beta 2 and gamma 2 subunits in human embryonic kidney cells produced functional receptors which are similar to the wild type in their sensitivity to a benzodiazepine agonist (U-92330), insensitivity to Zn, anion permeability, and GABA dose-response profiles as monitored with the whole cell patch clamp technique.	Benzodiazepines	185-199	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-52
7828377-8	1995	Our observations account for reported drug interactions involving midazolam and suggest that patients with low CYP3A4 activity may be most susceptible to prolonged amnestic effects occasionally produced by this short-acting benzodiazepine.	Benzodiazepines	224-238	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
7841044-7	1995	In contrast, both the isoquinoline carboxamide PK11195 and the benzodiazepine Ro 5-4864 ligands, displaying a high affinity for the MBR, did affect ALA-mediated phototoxicity, each markedly increasing the EC50 for cell photodestruction and thus exerting a photoprotective effect.	Benzodiazepines	63-77	translocator protein	Rattus norvegicus	132-135
7869102-11	1995	Developing thalamic neurons (p5-p25) showed similar potency and efficacy of the high-affinity benzodiazepine site to cortical neurons.	Benzodiazepines	94-108	lipocalin 2	Rattus norvegicus	32-35
22298398-0	1995	Buspirone treatment as an aid to benzodiazepine withdrawal.	Benzodiazepines	33-47	activation induced cytidine deaminase	Homo sapiens	26-29
7799410-4	1994	Notably, the alpha 1 and alpha 6 variants confer high and low affinity for BZ agonists to the resulting receptor subtype, respectively.	Benzodiazepines	75-77	adrenoceptor alpha 1D	Homo sapiens	13-32
7808437-2	1994	The human PBR can be labeled with the benzodiazepine Ro5-4864 and with the isoquinoline carboxamide PK11195.	Benzodiazepines	38-52	translocator protein	Homo sapiens	10-13
7964756-9	1994	The rapid regulation of allosteric coupling by benzodiazepine treatment of the stably transfected cells should provide insights to the mechanisms of coupling between GABAA and benzodiazepine receptors as well as benzodiazepine tolerance.	Benzodiazepines	47-61	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	166-171
7964756-9	1994	The rapid regulation of allosteric coupling by benzodiazepine treatment of the stably transfected cells should provide insights to the mechanisms of coupling between GABAA and benzodiazepine receptors as well as benzodiazepine tolerance.	Benzodiazepines	176-190	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	166-171
7964756-0	1994	Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.	Benzodiazepines	0-14	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	58-63
7932591-15	1994	The 3D-MSA-QSAR results have led to the proposal of a 3D pharmacophore model for the benzodiazepine CCK-A antagonists.	Benzodiazepines	85-99	cholecystokinin A receptor	Homo sapiens	100-105
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	190-193	diazepam binding inhibitor	Rattus norvegicus	28-31
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	190-193	diazepam binding inhibitor	Rattus norvegicus	88-108
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	173-188	diazepam binding inhibitor	Rattus norvegicus	0-26
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	190-193	diazepam binding inhibitor	Rattus norvegicus	110-113
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	173-188	diazepam binding inhibitor	Rattus norvegicus	28-31
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	173-188	diazepam binding inhibitor	Rattus norvegicus	88-108
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	173-188	diazepam binding inhibitor	Rattus norvegicus	110-113
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	173-188	diazepam binding inhibitor	Rattus norvegicus	132-135
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	190-193	diazepam binding inhibitor	Rattus norvegicus	0-26
7840424-1	1994	Diazepam-binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), that share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	190-193	diazepam binding inhibitor	Rattus norvegicus	132-135
10150261-7	1994	This partial agonist of the 5-HT1A receptor has been demonstrated to be as effective as benzodiazepines in controlling generalized anxiety symptoms and to have a more favorable side-effect profile.	Benzodiazepines	88-103	5-hydroxytryptamine receptor 1A	Homo sapiens	28-43
7819126-1	1994	A recognition site for benzodiazepines structurally different from that linked to the gamma-aminobutyric acid receptor subtype A or the "central type" benzodiazepine receptor has been located mainly in the outer membranes of mitochondria and designated mitochondrial benzodiazepine receptor (MBR).	Benzodiazepines	23-38	translocator protein	Rattus norvegicus	253-290
7819126-1	1994	A recognition site for benzodiazepines structurally different from that linked to the gamma-aminobutyric acid receptor subtype A or the "central type" benzodiazepine receptor has been located mainly in the outer membranes of mitochondria and designated mitochondrial benzodiazepine receptor (MBR).	Benzodiazepines	23-38	translocator protein	Rattus norvegicus	292-295
7819126-2	1994	A putative endogenous ligand for MBR is the peptide, diazepam binding inhibitor (DBI), which inhibits benzodiazepine ligand binding in mitochondrial membranes.	Benzodiazepines	102-116	translocator protein	Rattus norvegicus	33-36
7819126-2	1994	A putative endogenous ligand for MBR is the peptide, diazepam binding inhibitor (DBI), which inhibits benzodiazepine ligand binding in mitochondrial membranes.	Benzodiazepines	102-116	diazepam binding inhibitor	Rattus norvegicus	53-79
7819126-2	1994	A putative endogenous ligand for MBR is the peptide, diazepam binding inhibitor (DBI), which inhibits benzodiazepine ligand binding in mitochondrial membranes.	Benzodiazepines	102-116	diazepam binding inhibitor	Rattus norvegicus	81-84
7524106-1	1994	We recently reported that inhibition of nitric oxide (NO) production by the NO synthase (NOS) inhibitor L-NG-nitro arginine (L-NOARG) antagonized the behavioral effects of a benzodiazepine (BZ) in a mouse paradigm for screening anxiolytic drug activity.	Benzodiazepines	174-188	nitric oxide synthase 1, neuronal	Mus musculus	76-87
7524106-1	1994	We recently reported that inhibition of nitric oxide (NO) production by the NO synthase (NOS) inhibitor L-NG-nitro arginine (L-NOARG) antagonized the behavioral effects of a benzodiazepine (BZ) in a mouse paradigm for screening anxiolytic drug activity.	Benzodiazepines	190-192	nitric oxide synthase 1, neuronal	Mus musculus	76-87
8022401-4	1994	Receptors containing gamma 2 or gamma 3 subunits were labeled by benzodiazepine site ligands with high affinity, whereas gamma 1-containing receptors could be labeled only by [3H]muscimol.	Benzodiazepines	65-79	crystallin, gamma E	Rattus norvegicus	21-28
7712133-3	1994	Derived by chemical modification of the benzodiazepine ring system embedded within the CCK-B antagonist L-365,260, these compounds display CCK-B/CCK-A selectivity and some analogs have receptor binding affinities in the subnanomolar range.	Benzodiazepines	40-54	cholecystokinin B receptor	Homo sapiens	87-92
7712133-3	1994	Derived by chemical modification of the benzodiazepine ring system embedded within the CCK-B antagonist L-365,260, these compounds display CCK-B/CCK-A selectivity and some analogs have receptor binding affinities in the subnanomolar range.	Benzodiazepines	40-54	cholecystokinin B receptor	Homo sapiens	139-144
7712133-3	1994	Derived by chemical modification of the benzodiazepine ring system embedded within the CCK-B antagonist L-365,260, these compounds display CCK-B/CCK-A selectivity and some analogs have receptor binding affinities in the subnanomolar range.	Benzodiazepines	40-54	cholecystokinin A receptor	Homo sapiens	145-150
8082875-1	1994	A number of experimental studies clearly suggest that benzodiazepines attenuate the corticotropin-releasing hormone (CRH) secretion possibly through inhibitory GABAergic neurons.	Benzodiazepines	54-69	corticotropin releasing hormone	Homo sapiens	84-115
7522714-4	1994	These results indicate that the B-36 VDAC protein is heterogeneously distributed among different cerebral regions in different species and suggest that this protein would be associated with the alpha-1 subunit of the GABAA receptor (benzodiazepine binding sites).	Benzodiazepines	233-247	voltage-dependent anion channel 2	Rattus norvegicus	32-41
8182424-9	1994	Both effects were mediated by benzodiazepine-insensitive GABAA receptors.	Benzodiazepines	30-44	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	57-62
11224261-0	1994	Assessment of the benzodiazepine-like dependence potential in rats of the putative 5-HT(1A) agonist anxiolytic S-20499.	Benzodiazepines	18-32	5-hydroxytryptamine receptor 1A	Rattus norvegicus	83-90
8082875-1	1994	A number of experimental studies clearly suggest that benzodiazepines attenuate the corticotropin-releasing hormone (CRH) secretion possibly through inhibitory GABAergic neurons.	Benzodiazepines	54-69	corticotropin releasing hormone	Homo sapiens	117-120
8082875-3	1994	A comparison of the effects of a benzodiazepine on the stress- and CRH-induced activation in man has not been undertaken so far.	Benzodiazepines	33-47	corticotropin releasing hormone	Homo sapiens	67-70
7914003-0	1994	Peripheral benzodiazepine stimulates secretion of growth hormone and mitochondrial proliferation in pituitary tumour GH3 cells.	Benzodiazepines	11-25	gonadotropin releasing hormone receptor	Rattus norvegicus	50-64
7911985-2	1994	The number of TH-positive cells was increased for both ISH and IMHC 8 h after a single administration of benzodiazepine diazepam, which facilitates GABAA-receptor-mediated transmission and reduces dopamine release in the substantia nigra (SN).	Benzodiazepines	105-119	tyrosine hydroxylase	Rattus norvegicus	14-16
8183244-9	1994	The regional distribution and time course of reduced gamma 2 levels matched the decrease in benzodiazepine binding produced by the same chronic flurazepam treatment.	Benzodiazepines	92-106	crystallin, gamma E	Rattus norvegicus	53-60
8183244-13	1994	These results suggest that benzodiazepine receptor down-regulation after chronic benzodiazepine treatment may be related to the reduced expression of gamma 2 subunit mRNA, and they also suggest differential temporal and regional regulation of alpha 5 and gamma 2 subunit mRNAs in rat brain.	Benzodiazepines	27-41	crystallin, gamma E	Rattus norvegicus	150-157
8183244-13	1994	These results suggest that benzodiazepine receptor down-regulation after chronic benzodiazepine treatment may be related to the reduced expression of gamma 2 subunit mRNA, and they also suggest differential temporal and regional regulation of alpha 5 and gamma 2 subunit mRNAs in rat brain.	Benzodiazepines	27-41	crystallin, gamma E	Rattus norvegicus	255-262
8024534-6	1994	C57BL/6J and A/J mice should be useful parental strains in recombinant inbred lines for investigating the genetic determinants of benzodiazepine-sensitive behaviors and sensitivity to drugs acting on the GABAA/benzodiazepine receptor complex.	Benzodiazepines	130-144	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	204-209
8183240-10	1994	Taken together, these results suggest that chronic benzodiazepine treatment produces uncoupling of GABA and pentobarbital sites from the benzodiazepine site and decreased coupling between the benzodiazepine site and GABA receptor-gated Cl- channels.	Benzodiazepines	51-65	GABA type A receptor-associated protein	Homo sapiens	216-229
11224256-0	1994	Anxiolytic-like effects of 5-HT(1A) agonists in drug-naive and in benzodiazepine-experienced rats.	Benzodiazepines	66-80	5-hydroxytryptamine receptor 1A	Rattus norvegicus	27-34
8307574-2	1993	The mBzR consists of three components; the 18-kDa component on the outer mitochondrial membrane appears to contain the benzodiazepine binding site, and is hence often termed the peripheral benzodiazepine receptor (PBR).	Benzodiazepines	119-133	translocator protein	Homo sapiens	214-217
7990651-5	1994	Although 4"-Cl-diazepam affinity is reported to vary between tissues from different species, this is the first report of an in vivo hormone treatment induced change in the benzodiazepine type PBR affinity.	Benzodiazepines	172-186	translocator protein	Rattus norvegicus	192-195
8277510-4	1993	Details of the ability to modulate the receptor interactions of these benzodiazepines by appropriate structure modifications are discussed which imply the possibility of further refining the CCK-B receptor affinity and selectivity of this class of compounds.	Benzodiazepines	70-85	cholecystokinin B receptor	Homo sapiens	191-205
8298983-0	1993	Benzodiazepines antagonize central corticotropin releasing hormone-induced suppression of natural killer cell activity.	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	35-66
8298983-1	1993	Benzodiazepines have anxiolytic properties and attenuate behavioral stress responses induced by corticotropin releasing hormone (CRH).	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	96-127
8298983-1	1993	Benzodiazepines have anxiolytic properties and attenuate behavioral stress responses induced by corticotropin releasing hormone (CRH).	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	129-132
8114671-1	1994	The peripheral-type benzodiazepine receptor (PBR) was identified and characterized by its high affinity for two distinct classes of compounds, the benzodiazepines (BZs) and the isoquinolines (IQs).	Benzodiazepines	147-162	translocator protein	Mus musculus	4-43
8114671-1	1994	The peripheral-type benzodiazepine receptor (PBR) was identified and characterized by its high affinity for two distinct classes of compounds, the benzodiazepines (BZs) and the isoquinolines (IQs).	Benzodiazepines	147-162	translocator protein	Mus musculus	45-48
8114671-1	1994	The peripheral-type benzodiazepine receptor (PBR) was identified and characterized by its high affinity for two distinct classes of compounds, the benzodiazepines (BZs) and the isoquinolines (IQs).	Benzodiazepines	164-167	translocator protein	Mus musculus	4-43
8114671-1	1994	The peripheral-type benzodiazepine receptor (PBR) was identified and characterized by its high affinity for two distinct classes of compounds, the benzodiazepines (BZs) and the isoquinolines (IQs).	Benzodiazepines	164-167	translocator protein	Mus musculus	45-48
8114671-4	1994	Expression of mPBR cDNA in simian virus 40-transformed 3T3 fibroblasts resulted in an increase in the density of both BZ and IQ binding sites.	Benzodiazepines	118-120	resistance to Paracoccidioides brasiliensis	Mus musculus	14-18
8114671-11	1994	These results provide strong evidence that PBR is not a single protein receptor but a multimeric complex in which the IQ binding site is on the M(r) 18,000 subunit and expression of the BZ binding site requires both the M(r) 18,000 and 34,000 voltage-dependent anion channel subunits.	Benzodiazepines	186-188	translocator protein	Mus musculus	43-46
8262176-1	1993	The 18 kDa peripheral benzodiazepine receptor (PBR) can be labelled by benzodiazepines, such as Ro5-4864, and isoquinoline carboxamides such as PK11195.	Benzodiazepines	71-86	translocator protein	Homo sapiens	47-50
8194078-0	1993	The stress-induced reduction in monoamine oxidase (MAO) A activity is reversed by benzodiazepines: role of peripheral benzodiazepine receptors.	Benzodiazepines	82-97	monoamine oxidase A	Rattus norvegicus	51-54
8194078-2	1993	The effect of benzodiazepine pretreatment on the stress-induced decrease in MAO activity in rat tissues using footshock as stress model was investigated.	Benzodiazepines	14-28	monoamine oxidase A	Rattus norvegicus	76-79
8242240-2	1993	In this study, we compared two series of newly discovered ligands for their selectivity to benzodiazepine sites in the alpha 1 beta 2 gamma 2 and the alpha 6 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acidA (GABAA) receptors, the latter being unique in not interacting with classical benzodiazepines.	Benzodiazepines	91-105	adrenoceptor alpha 1D	Homo sapiens	119-141
8153057-7	1993	From these and our earlier data it is evident that prenatal exposure to low doses of benzodiazepines can result in long-lasting alterations of the cytokine network, as indicated by reduced release of TNF-alpha, IL-1, IL-6, IL-2 and interferon-gamma.	Benzodiazepines	85-100	tumor necrosis factor	Rattus norvegicus	200-209
8153057-7	1993	From these and our earlier data it is evident that prenatal exposure to low doses of benzodiazepines can result in long-lasting alterations of the cytokine network, as indicated by reduced release of TNF-alpha, IL-1, IL-6, IL-2 and interferon-gamma.	Benzodiazepines	85-100	interleukin 1 complex	Mus musculus	211-215
8153057-7	1993	From these and our earlier data it is evident that prenatal exposure to low doses of benzodiazepines can result in long-lasting alterations of the cytokine network, as indicated by reduced release of TNF-alpha, IL-1, IL-6, IL-2 and interferon-gamma.	Benzodiazepines	85-100	interleukin 6	Rattus norvegicus	217-221
8153057-7	1993	From these and our earlier data it is evident that prenatal exposure to low doses of benzodiazepines can result in long-lasting alterations of the cytokine network, as indicated by reduced release of TNF-alpha, IL-1, IL-6, IL-2 and interferon-gamma.	Benzodiazepines	85-100	interleukin 2	Rattus norvegicus	223-227
8153057-7	1993	From these and our earlier data it is evident that prenatal exposure to low doses of benzodiazepines can result in long-lasting alterations of the cytokine network, as indicated by reduced release of TNF-alpha, IL-1, IL-6, IL-2 and interferon-gamma.	Benzodiazepines	85-100	interferon gamma	Rattus norvegicus	232-248
8274578-1	1993	Diazepam-binding inhibitor (DBI) is a 9-kD neuropeptide that interacts with the benzodiazepine (BZD) binding sites of the neuronal gamma-aminobutyric acid type A (GABAA) receptor and with the glial mitochondrial BZD receptor (MBR).	Benzodiazepines	80-94	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
8274578-1	1993	Diazepam-binding inhibitor (DBI) is a 9-kD neuropeptide that interacts with the benzodiazepine (BZD) binding sites of the neuronal gamma-aminobutyric acid type A (GABAA) receptor and with the glial mitochondrial BZD receptor (MBR).	Benzodiazepines	80-94	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	28-31
8274578-1	1993	Diazepam-binding inhibitor (DBI) is a 9-kD neuropeptide that interacts with the benzodiazepine (BZD) binding sites of the neuronal gamma-aminobutyric acid type A (GABAA) receptor and with the glial mitochondrial BZD receptor (MBR).	Benzodiazepines	96-99	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
8274578-1	1993	Diazepam-binding inhibitor (DBI) is a 9-kD neuropeptide that interacts with the benzodiazepine (BZD) binding sites of the neuronal gamma-aminobutyric acid type A (GABAA) receptor and with the glial mitochondrial BZD receptor (MBR).	Benzodiazepines	96-99	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	28-31
8111002-1	1993	In order to explore the potential clinical utility of CCK-B antagonists for the treatment of benzodiazepine withdrawal symptoms, the auditory startle reflex was examined in rats undergoing withdrawal from the chronic administration of diazepam.	Benzodiazepines	93-107	cholecystokinin B receptor	Homo sapiens	54-59
8111002-5	1993	These results support the hypothesis that the selective CCK-B antagonist LY288513 may be an effective treatment for alleviating at least some benzodiazepine withdrawal symptoms in man.	Benzodiazepines	142-156	cholecystokinin B receptor	Homo sapiens	56-61
8242240-10	1993	We propose that the benzodiazepine site of the alpha 6 beta 2 gamma 2 subtype shares overlapping regions with that of the alpha 1 beta 2 gamma 2 subtype, but has a sterically restricted out-of-plane region, which may be also incompatible with the 5-phenyl group of classical benzodiazepines.	Benzodiazepines	20-34	adrenoceptor alpha 1D	Homo sapiens	122-144
7901754-0	1993	Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors.	Benzodiazepines	77-91	adrenoceptor alpha 1D	Homo sapiens	115-173
8221702-4	1993	It appears that the PBR are composed of three subunits: an 18-kDa subunit that binds isoquinoline carboxamide derivatives; a 30-kDa subunit that binds benzodiazepines; and a 32-kDa subunit labeled by the benzodiazepine [3H]AHN 086, the voltage-dependent anion channel.	Benzodiazepines	151-166	translocator protein	Homo sapiens	20-23
8221702-4	1993	It appears that the PBR are composed of three subunits: an 18-kDa subunit that binds isoquinoline carboxamide derivatives; a 30-kDa subunit that binds benzodiazepines; and a 32-kDa subunit labeled by the benzodiazepine [3H]AHN 086, the voltage-dependent anion channel.	Benzodiazepines	151-165	translocator protein	Homo sapiens	20-23
7901754-1	1993	Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites.	Benzodiazepines	218-232	adrenoceptor alpha 1D	Homo sapiens	136-143
7901754-1	1993	Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites.	Benzodiazepines	218-232	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	144-150
7901754-1	1993	Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites.	Benzodiazepines	218-232	adrenoceptor alpha 1D	Homo sapiens	163-170
7901754-1	1993	Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites.	Benzodiazepines	218-232	adrenoceptor alpha 1D	Homo sapiens	163-170
7901754-7	1993	These data indicate that, in the presence of gamma 2, beta 2 may substitute for alpha 1 in forming the benzodiazepine site of limited sensitivity to the type 1 ligands.	Benzodiazepines	103-117	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	54-60
7901754-7	1993	These data indicate that, in the presence of gamma 2, beta 2 may substitute for alpha 1 in forming the benzodiazepine site of limited sensitivity to the type 1 ligands.	Benzodiazepines	103-117	adrenoceptor alpha 1D	Homo sapiens	80-87
7901754-8	1993	It appears that individual ligands for benzodiazepine sites have their own sets of interacting domains, which are distributed in alpha 1 and gamma 2, and the agonistic activity of type 1 ligands may be more dependent on the alpha 1-specific domains than is that of less selective ligands.	Benzodiazepines	39-53	adrenoceptor alpha 1D	Homo sapiens	129-148
7901754-8	1993	It appears that individual ligands for benzodiazepine sites have their own sets of interacting domains, which are distributed in alpha 1 and gamma 2, and the agonistic activity of type 1 ligands may be more dependent on the alpha 1-specific domains than is that of less selective ligands.	Benzodiazepines	39-53	adrenoceptor alpha 1D	Homo sapiens	129-136
8347138-5	1993	Numerous analogues of the three lead compounds were then tested to determine the relationship between benzodiazepine structure and the ability to stimulate t-PA production.	Benzodiazepines	102-116	plasminogen activator, tissue type	Homo sapiens	156-160
8396935-1	1993	High affinity "peripheral-type" benzodiazepine binding sites were detected in an interleukin-1 (IL-1) responsive murine thymoma cell line EL4.NOB-1.	Benzodiazepines	32-46	interleukin 1 complex	Mus musculus	81-94
8396935-1	1993	High affinity "peripheral-type" benzodiazepine binding sites were detected in an interleukin-1 (IL-1) responsive murine thymoma cell line EL4.NOB-1.	Benzodiazepines	32-46	interleukin 1 complex	Mus musculus	96-100
8396935-1	1993	High affinity "peripheral-type" benzodiazepine binding sites were detected in an interleukin-1 (IL-1) responsive murine thymoma cell line EL4.NOB-1.	Benzodiazepines	32-46	epilepsy 4	Mus musculus	138-141
8396935-1	1993	High affinity "peripheral-type" benzodiazepine binding sites were detected in an interleukin-1 (IL-1) responsive murine thymoma cell line EL4.NOB-1.	Benzodiazepines	32-46	NIN1/RPN12 binding protein 1 homolog	Mus musculus	142-147
8395561-6	1993	The pronounced expression of alpha 2 and alpha 6 subunits suggests type II and "cerebellar-type" benzodiazepine pharmacology in the cochlea.	Benzodiazepines	97-111	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	41-48
8347138-10	1993	The ability of the benzodiazepines to stimulate t-PA production, however, appeared to be related to their platelet-activating factor (PAF) antagonist activity.	Benzodiazepines	19-34	plasminogen activator, tissue type	Homo sapiens	48-52
8347138-10	1993	The ability of the benzodiazepines to stimulate t-PA production, however, appeared to be related to their platelet-activating factor (PAF) antagonist activity.	Benzodiazepines	19-34	PCNA clamp associated factor	Homo sapiens	106-132
8347138-10	1993	The ability of the benzodiazepines to stimulate t-PA production, however, appeared to be related to their platelet-activating factor (PAF) antagonist activity.	Benzodiazepines	19-34	PCNA clamp associated factor	Homo sapiens	134-137
8347138-12	1993	While the precise mechanism of action is not yet clear, selected benzodiazepine analogues possessing PAF antagonist activity stimulate the production of t-PA by endothelial cells in vitro.	Benzodiazepines	65-79	PCNA clamp associated factor	Homo sapiens	101-104
8347138-12	1993	While the precise mechanism of action is not yet clear, selected benzodiazepine analogues possessing PAF antagonist activity stimulate the production of t-PA by endothelial cells in vitro.	Benzodiazepines	65-79	plasminogen activator, tissue type	Homo sapiens	153-157
7690351-0	1993	Effect of free fatty acids on the binding kinetics at the benzodiazepine binding site of glycated human serum albumin.	Benzodiazepines	58-72	albumin	Homo sapiens	104-117
8396957-6	1993	mean) was increased vs controls (8083 +/- 557 fmol mg-1 protein) in the platelets of patients taking a polypharmacy regime including the benzodiazepine clobazam (12661 +/- 1011 fmol mg-1 protein, P < 0.005) and also in those receiving sodium valproate as monotherapy (15003 +/- 1756 fmol mg-1 protein, P < 0.01).	Benzodiazepines	137-151	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	51-55
8396957-6	1993	mean) was increased vs controls (8083 +/- 557 fmol mg-1 protein) in the platelets of patients taking a polypharmacy regime including the benzodiazepine clobazam (12661 +/- 1011 fmol mg-1 protein, P < 0.005) and also in those receiving sodium valproate as monotherapy (15003 +/- 1756 fmol mg-1 protein, P < 0.01).	Benzodiazepines	137-151	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	182-186
8396957-6	1993	mean) was increased vs controls (8083 +/- 557 fmol mg-1 protein) in the platelets of patients taking a polypharmacy regime including the benzodiazepine clobazam (12661 +/- 1011 fmol mg-1 protein, P < 0.005) and also in those receiving sodium valproate as monotherapy (15003 +/- 1756 fmol mg-1 protein, P < 0.01).	Benzodiazepines	137-151	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	182-186
8394772-6	1993	By contrast, muscarinic M1 and M2, 5-HT1A, benzodiazepine (including zolpidem-insensitive binding), NMDA (MK801), and AMPA/QUIS receptors were higher in CA1 and/or subiculum.	Benzodiazepines	43-57	carbonic anhydrase 1	Homo sapiens	153-156
8388014-0	1993	Benzodiazepine antagonism of thyrotrophin-releasing hormone receptors: biphasic actions on growth hormone secretion in domestic fowl.	Benzodiazepines	0-14	thyrotropin releasing hormone	Gallus gallus	29-59
8104032-2	1993	Microiontophoretic studies showing that benzodiazepines selectively antagonized CCK-induced excitation of rat hippocampal neurons have led to the hypothesis that CCK is an anxiogenic peptide.	Benzodiazepines	40-55	cholecystokinin	Rattus norvegicus	80-83
8104032-2	1993	Microiontophoretic studies showing that benzodiazepines selectively antagonized CCK-induced excitation of rat hippocampal neurons have led to the hypothesis that CCK is an anxiogenic peptide.	Benzodiazepines	40-55	cholecystokinin	Rattus norvegicus	162-165
8391122-0	1993	Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.	Benzodiazepines	132-146	adrenoceptor alpha 1D	Homo sapiens	175-182
8097734-8	1993	The response to CCK was inhibited in a competitive manner by the addition of the benzodiazepine analog, MK-329.	Benzodiazepines	81-95	cholecystokinin	Homo sapiens	16-19
8332543-6	1993	These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.	Benzodiazepines	132-147	angiotensinogen	Homo sapiens	38-41
8384990-11	1993	The combined action of peripheral-type benzodiazepines on calcium influx and precursor conversion may be responsible for the observed inhibition of Ang-II-, K(+)-, or ACTH-induced aldosterone secretion.	Benzodiazepines	39-54	proopiomelanocortin	Homo sapiens	167-171
8327552-11	1993	These results not only provide new information on a neurotransmitter involved in the amnesic effects of benzodiazepines and ethanol-induced memory blackouts, but also testable hypotheses concerning recent observations that angiotensin converting enzyme (ACE) inhibitors elevate mood and improve certain cognitive processes in the elderly.	Benzodiazepines	104-119	angiotensin I converting enzyme	Rattus norvegicus	223-252
8327552-11	1993	These results not only provide new information on a neurotransmitter involved in the amnesic effects of benzodiazepines and ethanol-induced memory blackouts, but also testable hypotheses concerning recent observations that angiotensin converting enzyme (ACE) inhibitors elevate mood and improve certain cognitive processes in the elderly.	Benzodiazepines	104-119	angiotensin I converting enzyme	Rattus norvegicus	254-257
8491257-3	1993	These results show that, in some neuronal groups, CCK mRNA expression is regulated by benzodiazepines, although there is no clear link between CCK mRNA levels and anxiety state.	Benzodiazepines	86-101	cholecystokinin	Rattus norvegicus	50-53
8384990-3	1993	Peripheral-type binding sites for benzodiazepines are particularly abundant in steroidogenic tissues and have been proposed to be involved in the steroidogenic action of ACTH in Y-1 adrenocortical cells.	Benzodiazepines	34-49	proopiomelanocortin	Homo sapiens	170-174
8384990-8	1993	In glomerulosa cells loaded with a fluorescent Ca2+ probe, benzodiazepines blocked Ca2+ influx triggered by K+ or Ang-II without affecting the release of Ca2+ from intracellular stores induced by Ang-II.	Benzodiazepines	59-74	angiotensinogen	Homo sapiens	114-120
8384990-11	1993	The combined action of peripheral-type benzodiazepines on calcium influx and precursor conversion may be responsible for the observed inhibition of Ang-II-, K(+)-, or ACTH-induced aldosterone secretion.	Benzodiazepines	39-54	angiotensinogen	Homo sapiens	148-154
8098864-8	1993	After 2 weeks of daily injections of diazepam the levels of binding of somatostatin in the hippocampus returned to control values, coinciding with the tolerance that develops to chronically-administered benzodiazepine agonists.	Benzodiazepines	203-217	somatostatin	Rattus norvegicus	71-83
7681105-4	1993	The results suggest that anesthetics with simple structures may act on the GABAA receptor protein complex to modulate the Cl- channel activity and provide a molecular explanation for the synergistic clinical interactions between benzodiazepines and general anesthetics.	Benzodiazepines	229-244	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	75-80
8098864-9	1993	These results suggest that somatostatin receptors might be regulated by benzodiazepine receptors and perhaps may also play a role in some of the behavioural effects of the benzodiazepines.	Benzodiazepines	172-187	somatostatin	Rattus norvegicus	27-39
8380885-0	1993	Modulation of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, and granulocyte/macrophage colony-stimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins.	Benzodiazepines	204-218	colony stimulating factor 2	Homo sapiens	97-145
8095340-5	1993	In females, but not males, these calls were reduced in number by gepirone, 5-hydroxytryptamine1A (5-HT1A) agonist, at both 1.0- and 10.0-mg/kg doses and by diazepam, a benzodiazepine, at 3.0 but not 1.0 mg/kg.	Benzodiazepines	168-182	5-hydroxytryptamine receptor 1A	Rattus norvegicus	98-104
8102067-3	1993	Using a high performance liquid chromatographic (HPLC) column containing HSA as stationary phase, their influence was investigated on the separation in this phase of the enantiomers of three benzodiazepines (temazepam, oxazepam, and lorazepam).	Benzodiazepines	191-206	albumin	Homo sapiens	73-76
8380386-12	1993	Then, we partially purified the DBI present in conditioned medium and interstitial fluid by reverse phase chromatography and demonstrated it to be bioactive, based on displacement of a radiolabeled benzodiazepine (Ro5-4864)-specific ligand for PBR; pronase treatment of different preparations eliminated all bioactivity.	Benzodiazepines	198-212	diazepam binding inhibitor	Mus musculus	32-35
7917836-2	1993	Studies of in vitro hippocampal slices following 1 wk flurazepam administration show reduced GABA-mediated inhibition in the CA1 region, and a decrease in GABAA agonist and benzodiazepine potency to inhibit CA1 pyramidal cell-evoked responses.	Benzodiazepines	173-187	carbonic anhydrase 1	Rattus norvegicus	207-210
8383812-0	1993	Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices.	Benzodiazepines	0-14	carbonic anhydrase 1	Cavia porcellus	66-69
8383812-0	1993	Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices.	Benzodiazepines	0-14	carbonic anhydrase 3	Cavia porcellus	74-77
8385255-1	1993	Since their first description as anomalous high affinity diazepam binding sites in rat peripheral tissues, the peripheral-type benzodiazepine receptor (PBR) has been increasingly studied to better understand nonneural effects of the benzodiazepines.	Benzodiazepines	233-248	translocator protein	Rattus norvegicus	152-155
1282920-4	1992	In a previous study, we have examined the developmental expression of binding sites for [3H]muscimol, which binds with high affinity to the beta subunits of the GABAA/benzodiazepine (GABAA/BZ) receptor.	Benzodiazepines	167-181	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	161-166
1282920-4	1992	In a previous study, we have examined the developmental expression of binding sites for [3H]muscimol, which binds with high affinity to the beta subunits of the GABAA/benzodiazepine (GABAA/BZ) receptor.	Benzodiazepines	167-181	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	183-188
1334371-2	1992	STHE responds dramatically to the benzodiazepine drug clonazepam, which acts at gamma-aminobutyric acid type A (GABA-A) receptors.	Benzodiazepines	34-48	glycine receptor alpha 1	Homo sapiens	0-4
1360743-0	1992	The effects of alcohol and benzodiazepines on the severity of ski accidents.	Benzodiazepines	27-42	SKI proto-oncogene	Homo sapiens	62-65
1503150-0	1992	The treatment of catatonia: benzodiazepines of ECT?	Benzodiazepines	28-43	ECT	Homo sapiens	47-50
1321437-1	1992	The differential sensitivity of type A gamma-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be generated by the existence of a number of different receptor subtypes, assembled from a range of closely related subunits (alpha 1-6, beta 1-3, gamma 1-3, and delta) encoded by discrete genes.	Benzodiazepines	84-98	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	284-303
1406601-0	1992	Stereochemical aspects of benzodiazepine binding to human serum albumin.	Benzodiazepines	26-40	albumin	Homo sapiens	58-71
1406602-0	1992	Stereochemical aspects of benzodiazepine binding to human serum albumin.	Benzodiazepines	26-40	albumin	Homo sapiens	58-71
1426581-0	1992	Regulation of glutamate decarboxylase and enkephalin mRNA levels in rat striatum by chronic benzodiazepine treatment.	Benzodiazepines	92-106	glutamate-ammonia ligase	Rattus norvegicus	14-37
1426581-0	1992	Regulation of glutamate decarboxylase and enkephalin mRNA levels in rat striatum by chronic benzodiazepine treatment.	Benzodiazepines	92-106	proenkephalin	Rattus norvegicus	42-52
1480515-0	1992	Benzodiazepine suppression of corticotropin-releasing factor (CRF)-induced beta-endorphin release from rat neurointermediate pituitary.	Benzodiazepines	0-14	corticotropin releasing hormone	Rattus norvegicus	30-60
1397061-1	1992	The C3-substituted benzodiazepines derived from asperlicin, e.g. devazepide (L-364,718, MK-329), constitute the most potent class of cholecystokinin A-type (CCKA) receptor antagonists.	Benzodiazepines	19-34	cholecystokinin A receptor	Homo sapiens	133-171
1356807-6	1992	It is concluded that the reduction in aversive responding caused by pharmacological manipulation at the benzodiazepine, 5-HT receptor subtypes 5-HT1A, 5-HT1C/5-HT2 and 5-HT3 (but not at the cholecystokin CCKA or angiotensin receptors or inhibition of angiotensin converting enzyme) can be inhibited by R(+) and S(-)-zacopride.	Benzodiazepines	104-118	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	151-157
1321437-6	1992	Additionally, the recombinant receptors have the same benzodiazepine pharmacology as native alpha 1-containing GABAA receptors and function as GABA-gated chloride channels.	Benzodiazepines	54-68	adrenoceptor alpha 1D	Homo sapiens	92-99
1327839-2	1992	The effect of chronic exposure to the benzodiazepine agonist diazepam was also examined on levels of gamma 2 subunit mRNA.	Benzodiazepines	38-52	crystallin, gamma E	Rattus norvegicus	101-108
1472208-0	1992	Do benzodiazepines interfere with the action of ECT?	Benzodiazepines	3-18	ECT	Homo sapiens	48-51
1321425-2	1992	The gamma 1 and gamma 2 subunits have been shown to be important in mediating responses to benzodiazepines, and a splicing variant of the gamma 2 subunit, gamma 2L, has been shown to be necessary for ethanol actions on the receptor, raising the possibility that the gamma 2 gene may be involved in human genetic predisposition to the development of alcoholism.	Benzodiazepines	91-106	tryptophanyl-tRNA synthetase 1	Homo sapiens	16-23
1326109-0	1992	Effects of central and peripheral type benzodiazepine ligands on growth hormone and gonadotropin secretion in male rats.	Benzodiazepines	39-53	gonadotropin releasing hormone receptor	Rattus norvegicus	65-79
1573395-0	1992	Interleukin-1-beta and tumor necrosis factor-alpha increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes.	Benzodiazepines	76-90	interleukin 1 beta	Rattus norvegicus	0-18
1573395-0	1992	Interleukin-1-beta and tumor necrosis factor-alpha increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes.	Benzodiazepines	76-90	tumor necrosis factor	Rattus norvegicus	23-50
1504063-3	1992	In rat pituitary GH3 cells, BZs bind to receptors for thyrotropin-releasing hormone (TRH) and via interaction at a different site block Ca2+ influx through voltage-sensitive channels.	Benzodiazepines	28-31	thyrotropin releasing hormone	Rattus norvegicus	54-83
1323506-1	1992	The effects of chronic benzodiazepine (BZD) treatment on rat peripheral-type benzodiazepine receptors (PBR) were studied.	Benzodiazepines	39-42	translocator protein	Rattus norvegicus	61-101
1323506-1	1992	The effects of chronic benzodiazepine (BZD) treatment on rat peripheral-type benzodiazepine receptors (PBR) were studied.	Benzodiazepines	39-42	translocator protein	Rattus norvegicus	103-106
1323506-5	1992	The results suggest that chronic BZD exposure differentially regulates PBR in peripheral organs.	Benzodiazepines	33-36	translocator protein	Rattus norvegicus	71-74
1329159-2	1992	OBJECTIVES: The aim of this study was to evaluate the effects of four benzodiazepines on preoperative secretion of cortisol and ACTH.	Benzodiazepines	70-85	proopiomelanocortin	Homo sapiens	128-132
1321364-0	1992	Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.	Benzodiazepines	39-53	prolactin	Rattus norvegicus	81-90
1321364-9	1992	The sedating (or agitating in case of FG 7142) effect of high doses of benzodiazepine ligands may contribute to the changes in TSH and PRL levels.	Benzodiazepines	71-85	prolactin	Rattus norvegicus	135-138
1349746-3	1992	Thus, the 5-HT3 receptor antagonists are not sedative, they do not have addictive liabilities, there are no problems of withdrawing from chronic treatment and they can be used following benzodiazepine withdrawal.	Benzodiazepines	186-200	5-hydroxytryptamine receptor 3A	Rattus norvegicus	10-24
1313156-9	1992	A non-linear relationship was found between the reduction in dopamine D1 receptor binding in vivo and the occupancy of benzodiazepine receptors in vivo, indicating that benzodiazepines exerted the maximum change in dopamine receptor binding at a low fractional occupancy of receptors.	Benzodiazepines	169-184	dopamine receptor D1	Mus musculus	61-81
1346133-5	1992	Notably, the alpha 1 and alpha 6 variants impart on alpha chi beta 2 gamma 2 receptors high and negligible affinity, respectively, to BZ ligands with sedative as well as anxiolytic activities.	Benzodiazepines	134-136	adrenoceptor alpha 1D	Homo sapiens	13-32
1346133-7	1992	Furthermore, we identify a single histidine residue in the alpha 1 variant, replaced by an arginine in alpha 6, as a major determinant for high affinity binding of BZ agonists.	Benzodiazepines	164-166	adrenoceptor alpha 1D	Homo sapiens	59-66
1346133-9	1992	Hence, this histidine present in the alpha 1, alpha 2, alpha 3, and alpha 5 subunits appears to be a key residue for the action of clinically used BZ ligands.	Benzodiazepines	147-149	adrenoceptor alpha 1D	Homo sapiens	37-44
1350747-0	1992	The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988.	Benzodiazepines	18-32	cholecystokinin B receptor	Mus musculus	69-94
1635633-3	1992	The results show that DBI can objectively measure the anxiety relief, that not are correlate haematic levels of DBI and score scale, that the best benzodiazepines are diazepam (0.3) and flunitrazepam (0.015) and that the prometazine might give anxiety relief for 5-HT antagonist action.	Benzodiazepines	147-162	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	22-25
1618455-1	1992	An LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be applied successfully for the quantitative determination of thermolabile benzodiazepines in whole-blood following an Extrelut extraction method.	Benzodiazepines	167-182	thrombospondin 1	Homo sapiens	6-9
1311618-9	1992	Since benzodiazepines attenuate hypothalamic CRH secretion through GABAergic inhibition, we suggest that strain differences in receptor number could also augment strain differences in hypothalamic-pituitary-adrenal axis function through differential sensitivity to GABA-mediated feedback.	Benzodiazepines	6-21	corticotropin releasing hormone	Rattus norvegicus	45-48
1642965-0	1992	Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.	Benzodiazepines	70-85	albumin	Homo sapiens	95-108
1310339-1	1992	To investigate preliminary reports that benzodiazepine-induced sedation may be reversed by thyrotropin-releasing hormone (TRH), we examined the effect of TRH or saline placebo on two variables which are sensitive to benzodiazepine agonists: changes in sedation and saccadic eye movements.	Benzodiazepines	40-54	thyrotropin releasing hormone	Homo sapiens	91-120
1310339-1	1992	To investigate preliminary reports that benzodiazepine-induced sedation may be reversed by thyrotropin-releasing hormone (TRH), we examined the effect of TRH or saline placebo on two variables which are sensitive to benzodiazepine agonists: changes in sedation and saccadic eye movements.	Benzodiazepines	40-54	thyrotropin releasing hormone	Homo sapiens	122-125
1310339-1	1992	To investigate preliminary reports that benzodiazepine-induced sedation may be reversed by thyrotropin-releasing hormone (TRH), we examined the effect of TRH or saline placebo on two variables which are sensitive to benzodiazepine agonists: changes in sedation and saccadic eye movements.	Benzodiazepines	216-230	thyrotropin releasing hormone	Homo sapiens	122-125
1664786-1	1991	A [35S]cRNA probe was used for the visualization of GABAA/benzodiazepine (GABAA/BZ) receptor alpha 1 subunit mRNA in developing reeler mutant mouse cerebellum.	Benzodiazepines	58-72	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	74-79
1664068-8	1991	Flunitrazepam, a benzodiazepine which binds to mitochondrial benzodiazepine receptors, with high nanomolar affinity, inhibited the stimulatory action of DBI on the formation of mitochondrial pregnenolone, indicating that DBI exerts its stimulatory effects through an action on mitochondrial benzodiazepine receptors.	Benzodiazepines	17-31	diazepam binding inhibitor	Rattus norvegicus	153-156
1766000-1	1991	The intriguing structural similarities of glutamic acid based cholecystokinin (CCK) antagonists (A-64718 and A-65186) and the benzodiazepine CCK antagonist MK-329 (L-364,718) have been reported.	Benzodiazepines	126-140	cholecystokinin	Homo sapiens	141-144
1955561-0	1991	Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes.	Benzodiazepines	0-14	interleukin 1 beta	Homo sapiens	50-97
1955561-0	1991	Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes.	Benzodiazepines	0-14	interleukin 6	Homo sapiens	102-115
1664069-5	1991	Other lines of research suggest that DBI and DBI processing products may be important factors in behavioral adaptation to stress, acting via benzodiazepine (BZD) binding sites, located on mitochondria.	Benzodiazepines	141-155	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	37-40
1780035-6	1991	Moreover, the biosynthesis of DBI is up-regulated in the cerebellum and cerebral cortex of rats made tolerant to diazepam, suggesting that changes in the biosynthesis of DBI might be one of the mechanisms eliciting tolerance to benzodiazepine.	Benzodiazepines	228-242	diazepam binding inhibitor	Rattus norvegicus	30-33
1664069-5	1991	Other lines of research suggest that DBI and DBI processing products may be important factors in behavioral adaptation to stress, acting via benzodiazepine (BZD) binding sites, located on mitochondria.	Benzodiazepines	141-155	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	45-48
1780035-6	1991	Moreover, the biosynthesis of DBI is up-regulated in the cerebellum and cerebral cortex of rats made tolerant to diazepam, suggesting that changes in the biosynthesis of DBI might be one of the mechanisms eliciting tolerance to benzodiazepine.	Benzodiazepines	228-242	diazepam binding inhibitor	Rattus norvegicus	170-173
1664069-5	1991	Other lines of research suggest that DBI and DBI processing products may be important factors in behavioral adaptation to stress, acting via benzodiazepine (BZD) binding sites, located on mitochondria.	Benzodiazepines	157-160	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	37-40
1723508-6	1991	From these data, DBI is capable of reducing the activity of the GABAA receptor complex by specifically interacting with the benzodiazepine recognition site.	Benzodiazepines	124-138	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	17-20
1664069-5	1991	Other lines of research suggest that DBI and DBI processing products may be important factors in behavioral adaptation to stress, acting via benzodiazepine (BZD) binding sites, located on mitochondria.	Benzodiazepines	157-160	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	45-48
1797351-0	1991	Chronic benzodiazepine treatment of rats induces reduction of paired-pulse inhibition in CA1 region of in vitro hippocampus.	Benzodiazepines	8-22	carbonic anhydrase 1	Rattus norvegicus	89-92
1686670-0	1991	[Effect of alcohol and benzodiazepines on the severity of ski accidents].	Benzodiazepines	23-38	SKI proto-oncogene	Homo sapiens	58-61
1661635-1	1991	The gamma-aminobutyric acid type A (GABAA) receptor gamma 2-subunit is important for benzodiazepine action.	Benzodiazepines	85-99	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	36-41
1665550-1	1991	We compared the modulation of GABA (gamma-aminobutyric acid)-activated currents by benzodiazepines in recombinant GABAA receptors containing either one of two alpha subunits, alpha 1 or alpha 6.	Benzodiazepines	83-98	adrenoceptor alpha 1D	Homo sapiens	175-193
1664802-4	1991	This suggests that dihydrogenated ergot compounds, especially dihydroergotoxine, possess appreciable binding activity (comparable to that of benzodiazepines and barbiturates) at the GABAA receptor-associated C1- ionophore.	Benzodiazepines	141-156	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	182-187
1655526-2	1991	Recombinant receptors composed of alpha 4, beta 2 and gamma 2 subunit bind with high affinity the GABA agonist [3H]muscimol and the benzodiazepine "alcohol antagonist" [3H]Ro 15-4513, but fail to bind benzodiazepine agonists.	Benzodiazepines	132-146	crystallin, gamma E	Rattus norvegicus	54-61
1655526-2	1991	Recombinant receptors composed of alpha 4, beta 2 and gamma 2 subunit bind with high affinity the GABA agonist [3H]muscimol and the benzodiazepine "alcohol antagonist" [3H]Ro 15-4513, but fail to bind benzodiazepine agonists.	Benzodiazepines	201-215	crystallin, gamma E	Rattus norvegicus	54-61
1651852-10	1991	Flunitrazepam, a benzodiazepine that binds with high nanomolar affinity to MBR, was recently shown to act as an antagonist of ACTH and LH/hCG-induced steroidogenesis and was found in the present studies to inhibit DBI-stimulated mitochondrial steroidogenesis.	Benzodiazepines	17-31	translocator protein	Mus musculus	75-78
1663839-7	1991	The degree of discrepancy between the two profiles (receptor occupancy and biological response) concerning benzodiazepine concentration dependency and time dependency increased with a decrease in the dissociation constants based on the benzodiazepine receptor-GABA receptor interaction.	Benzodiazepines	107-121	GABA type A receptor-associated protein	Homo sapiens	260-273
1791923-1	1991	An endogenous peptide, named diazepam-binding inhibitor (DBI) capable of displacing benzodiazepines from binding sites has been recently fully characterized.	Benzodiazepines	84-99	diazepam binding inhibitor	Rattus norvegicus	29-55
1791923-1	1991	An endogenous peptide, named diazepam-binding inhibitor (DBI) capable of displacing benzodiazepines from binding sites has been recently fully characterized.	Benzodiazepines	84-99	diazepam binding inhibitor	Rattus norvegicus	57-60
1757727-4	1991	Both glutaramic acid derivatives and natural (benzodiazepine) analogs are potent, competitive antagonists of peripheral CCK receptors.	Benzodiazepines	46-60	cholecystokinin	Homo sapiens	120-123
1668366-4	1991	Administration of the anxiogenic beta-carboline FG 7142 also increased the total number of VTA DA neurons expressing Fos protein, whereas pretreatment with an anxiolytic benzodiazepine (diazepam) partially prevented the stress-induced increase in Fos expression.	Benzodiazepines	170-184	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	247-250
1654530-0	1991	Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum.	Benzodiazepines	28-42	thyrotropin releasing hormone	Rattus norvegicus	75-78
1654530-0	1991	Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum.	Benzodiazepines	28-42	thyrotropin releasing hormone	Rattus norvegicus	171-174
1658766-0	1991	Atipamezole, benzodiazepines, bicucullin and tifluadom antagonize the effect of TRH on rat duodenum and displace it from brain and anterior pituitary receptors.	Benzodiazepines	13-28	thyrotropin releasing hormone	Rattus norvegicus	80-83
1658766-3	1991	In contrast, the adrenergic alpha 2-antagonist atipamezole, the benzodiazepines chlordiaxepoxide and midazolam or GABA-A-antagonist bicucullin but not picrotoxin or SR-95531 attenuated the response to TRH.	Benzodiazepines	64-79	thyrotropin releasing hormone	Rattus norvegicus	201-204
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	Benzodiazepines	67-82	interleukin 1 alpha	Homo sapiens	109-148
1658766-4	1991	An opioid-kappa-receptor agonist having benzodiazepine structure, tifluadom, but not MR 2034 also diminished the response to TRH.	Benzodiazepines	40-54	thyrotropin releasing hormone	Rattus norvegicus	125-128
1677791-3	1991	Arnold Scaf presents such a model which describes the contribution of intrinsic activity to the selective anxiolytic/anticonvulsant action of fully and partially agonistic benzodiazepines.	Benzodiazepines	172-187	SR-related CTD associated factor 1	Homo sapiens	7-11
1678655-2	1991	The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes, as determined by specific immunoreactive and biological assays for these cytokines.	Benzodiazepines	73-76	tumor necrosis factor	Homo sapiens	146-167
1678655-2	1991	The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes, as determined by specific immunoreactive and biological assays for these cytokines.	Benzodiazepines	73-76	tumor necrosis factor	Homo sapiens	169-172
1678655-2	1991	The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes, as determined by specific immunoreactive and biological assays for these cytokines.	Benzodiazepines	73-76	interleukin 1 alpha	Homo sapiens	178-197
1664058-5	1991	Partial sequencing of proteolytic fragments of these polypeptides yielded sequences found in all alpha clones, and identified the benzodiazepine binding site within residues 8-297 and probably between 106-297 of alpha 1; the 44 kDa and 31 kDa bands yielded fragments containing alpha 3 sequence.	Benzodiazepines	130-144	adrenoceptor alpha 1D	Homo sapiens	212-219
1847192-8	1991	Codfish GABA receptor is postulated to be a homo-oligomer in which the conformation of GABA and BZ recognition sites is very similar to that in the mammalian hetero-oligomeric GABAA receptor.	Benzodiazepines	96-98	GABA type A receptor-associated protein	Homo sapiens	8-21
1847384-4	1991	Flunitrazepam, a benzodiazepine which binds to MBR with high nanomolar affinity, inhibited the steroidogenic activity of these hormones, or the activation by 1 mM dibutyryl cAMP, in both cell lines by 30-60% with an IC50 of 500-1000 nM.	Benzodiazepines	17-31	translocator protein	Homo sapiens	47-50
1996962-0	1991	Octanoate binding to the indole- and benzodiazepine-binding region of human serum albumin.	Benzodiazepines	37-51	albumin	Homo sapiens	76-89
1846404-2	1991	The gamma 2-subunit appears to be essential for benzodiazepine modulation of GABAA receptor function.	Benzodiazepines	48-62	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	77-82
1987812-0	1991	The APA Task Force report on benzodiazepine dependence, toxicity, and abuse.	Benzodiazepines	29-43	glutamyl aminopeptidase	Homo sapiens	4-7
1847678-1	1991	The sequencing of endopeptidase-generated peptides from the peripheral binding site (PBS) for benzodiazepines, purified from a Chinese hamster ovary (CHO) cell line, produced internal sequence information, and confirmed and extended the NH2-terminal PBS sequence that we previously reported.	Benzodiazepines	94-109	translocator protein	Homo sapiens	85-88
1688272-5	1991	Tricyclic antidepressants and benzodiazepines also bind calmodulin.	Benzodiazepines	30-45	calmodulin 1	Homo sapiens	56-66
1847885-2	1991	The effect of the benzodiazepines Ro5-4864, AHN 086 and clonazepam on the release of Ca2+ from rat heart and kidney mitochondria was studied.	Benzodiazepines	18-33	carbonic anhydrase 2	Rattus norvegicus	85-88
1847885-4	1991	The peripheral-type benzodiazepines Ro5-4864 and AHN 086 induced Ca2+ release which was blocked by Mg2+ whereas the central-type benzodiazepine clonazepam was ineffective.	Benzodiazepines	20-35	carbonic anhydrase 2	Rattus norvegicus	65-68
1847885-4	1991	The peripheral-type benzodiazepines Ro5-4864 and AHN 086 induced Ca2+ release which was blocked by Mg2+ whereas the central-type benzodiazepine clonazepam was ineffective.	Benzodiazepines	20-34	carbonic anhydrase 2	Rattus norvegicus	65-68
1847230-0	1991	The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines.	Benzodiazepines	85-100	translocator protein	Bos taurus	11-50
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	158-172	diazepam binding inhibitor	Rattus norvegicus	0-26
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	158-172	diazepam binding inhibitor	Rattus norvegicus	28-31
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	158-172	translocator protein	Rattus norvegicus	313-339
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	158-172	translocator protein	Rattus norvegicus	341-344
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	174-177	diazepam binding inhibitor	Rattus norvegicus	0-26
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	174-177	diazepam binding inhibitor	Rattus norvegicus	28-31
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	174-177	translocator protein	Rattus norvegicus	313-339
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Benzodiazepines	174-177	translocator protein	Rattus norvegicus	341-344
2205479-0	1990	Localization of the endogenous benzodiazepine ligand octadecaneuropeptide in the rat testis.	Benzodiazepines	31-45	diazepam binding inhibitor	Rattus norvegicus	53-73
1780419-5	1991	In deep inhaling smokers, smoking produced a symmetrical central midline increase in beta2 magnitude, an EEG effect that in the benzodiazepine literature is associated with anxiety relief.	Benzodiazepines	128-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-90
1963800-0	1990	Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist.	Benzodiazepines	101-115	acetylcholinesterase	Mus musculus	0-20
1963800-17	1990	It is concluded that chronic treatment with the benzodiazepine inverse agonist FG 7142 produces alterations in the acetylcholinesterase activities of various brain regions, in a manner related to the kindling that can be produced by this treatment.	Benzodiazepines	48-62	acetylcholinesterase	Mus musculus	115-135
1978727-0	1990	In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin-6.	Benzodiazepines	23-38	tumor necrosis factor	Mus musculus	104-140
1978727-0	1990	In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin-6.	Benzodiazepines	23-38	interleukin 6	Mus musculus	145-158
1680228-0	1991	Central-type benzodiazepines inhibit release of alpha-melanocyte-stimulating hormone from the rat hypothalamus.	Benzodiazepines	13-28	proopiomelanocortin	Rattus norvegicus	48-84
2172467-2	1990	Endogenous benzodiazepine ligands were extracted from rat brain and human CSF by acid treatment and purification by HPLC.	Benzodiazepines	11-25	colony stimulating factor 2	Homo sapiens	74-77
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	174-189	diazepam binding inhibitor	Rattus norvegicus	0-26
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	174-189	diazepam binding inhibitor	Rattus norvegicus	28-31
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	174-189	diazepam binding inhibitor	Rattus norvegicus	88-108
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	174-189	diazepam binding inhibitor	Rattus norvegicus	110-113
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	174-189	diazepam binding inhibitor	Rattus norvegicus	133-136
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	191-194	diazepam binding inhibitor	Rattus norvegicus	0-26
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	191-194	diazepam binding inhibitor	Rattus norvegicus	28-31
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	191-194	diazepam binding inhibitor	Rattus norvegicus	88-108
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	191-194	diazepam binding inhibitor	Rattus norvegicus	110-113
2205479-1	1990	Diazepam binding inhibitor (DBI) is the precursor of a family of peptides, including an octadecaneuropeptide (ODN), which share with DBI the ability to specifically displace benzodiazepines (BZD) from their receptors.	Benzodiazepines	191-194	diazepam binding inhibitor	Rattus norvegicus	133-136
2169744-0	1990	Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons.	Benzodiazepines	94-108	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	16-30
2174791-0	1990	Interaction of lipocortin I with peripheral-type benzodiazepine binding sites.	Benzodiazepines	49-63	annexin A1	Rattus norvegicus	15-27
2174791-2	1990	The results suggest the possibility of lipocortin I being involved in the function of peripheral-type benzodiazepine binding sites.	Benzodiazepines	102-116	annexin A1	Rattus norvegicus	39-51
2169744-1	1990	Chronic benzodiazepine agonist administration may lead to decreases in gamma-aminobutyric acidA (GABAA) receptor binding and function, but little information is available concerning chronic GABA-neutral or GABA-negative benzodiazepine exposure.	Benzodiazepines	8-22	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	71-112
2167683-1	1990	To examine the relationship between PKBS, a 17-kD protein covalently photolabeled by [3H]PK 14105, and its association with peripheral-type benzodiazepine binding sites, rat adrenal mitochondrial fractions were photolabeled with [3H]PK 14105, solubilized in digitonin, and subjected to anion-exchange chromatography over Q-Sepharose.	Benzodiazepines	140-154	translocator protein	Rattus norvegicus	36-40
2167683-7	1990	These studies provide direct biochemical evidence that the recognition sites for benzodiazepines and isoquinoline carboxamides cofractionate in unison with the 17-kD PKBS protein, demonstrating an intimate relationship between this protein and the binding domains for peripheral-type benzodiazepine ligands.	Benzodiazepines	81-96	translocator protein	Rattus norvegicus	166-170
2403378-5	1990	DIAZ and PROB displaced one another, confirming their common binding site (Site II, the benzodiazepine site) on serum albumin.	Benzodiazepines	88-102	albumin	Homo sapiens	112-125
1701826-0	1990	[Non-enzymatic glycation of human serum albumin: influence on thebinding kinetics of the benzodiazepine binding sites].	Benzodiazepines	89-103	albumin	Homo sapiens	40-47
2167683-7	1990	These studies provide direct biochemical evidence that the recognition sites for benzodiazepines and isoquinoline carboxamides cofractionate in unison with the 17-kD PKBS protein, demonstrating an intimate relationship between this protein and the binding domains for peripheral-type benzodiazepine ligands.	Benzodiazepines	81-95	translocator protein	Rattus norvegicus	166-170
1983213-7	1990	Only benzodiazepines could selectively suppress the neuronal activation induced by kainate, however, with a lower efficacy in the CA3 than in the CA1 region.	Benzodiazepines	5-20	carbonic anhydrase 3	Rattus norvegicus	130-133
1983213-7	1990	Only benzodiazepines could selectively suppress the neuronal activation induced by kainate, however, with a lower efficacy in the CA3 than in the CA1 region.	Benzodiazepines	5-20	carbonic anhydrase 1	Rattus norvegicus	146-149
1971720-0	1990	Benzodiazepines impair a behavioral effect induced by stimulation of 5-HT1B receptors.	Benzodiazepines	0-15	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	69-75
2171047-6	1990	Cells with high expression of DBI have been shown to contain a high density of mitochondrial benzodiazepine (BZ) binding sites.	Benzodiazepines	93-107	diazepam binding inhibitor	Rattus norvegicus	30-33
2171047-6	1990	Cells with high expression of DBI have been shown to contain a high density of mitochondrial benzodiazepine (BZ) binding sites.	Benzodiazepines	109-111	diazepam binding inhibitor	Rattus norvegicus	30-33
2171047-7	1990	This observation led us to perform a competitive binding assay between DBI and [3H]PK11195 (a ligand for the mitochondrial BZ binding sites) on mitochondrial membranes of adrenal cortical cells.	Benzodiazepines	123-125	diazepam binding inhibitor	Rattus norvegicus	71-74
2171047-8	1990	In this experiment, DBI yielded an apparent competitive inhibition of the binding of PK11195 to the BZ binding sites.	Benzodiazepines	100-102	diazepam binding inhibitor	Rattus norvegicus	20-23
2159487-12	1990	The capacity of Ro 15-1788 to reverse alprazolam-induced suppression of the CRH neuron indicates that the effects of alprazolam are mediated at least in part via its interaction with the benzodiazepine component of the gamma-aminobutyric acidA macromolecular complex.	Benzodiazepines	187-201	corticotropin releasing hormone	Rattus norvegicus	76-79
2160007-0	1990	Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels.	Benzodiazepines	0-14	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	54-59
2160008-0	1990	Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels.	Benzodiazepines	0-14	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	54-59
1692607-2	1990	Chronic exposure of cultures to GABA, benzodiazepines, or methylxanthines results in decreased enhancement of [3H]flunitrazepam binding by GABA, consistent with an allosteric uncoupling of GABA and benzodiazepine recognition sites of the GABAA receptor.	Benzodiazepines	38-53	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	238-252
1692607-2	1990	Chronic exposure of cultures to GABA, benzodiazepines, or methylxanthines results in decreased enhancement of [3H]flunitrazepam binding by GABA, consistent with an allosteric uncoupling of GABA and benzodiazepine recognition sites of the GABAA receptor.	Benzodiazepines	38-52	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	238-252
1971720-7	1990	These results suggest that tranquillizing drugs of the benzodiazepines group, but not of other groups, interact with the 5-HT1B receptors; they add to the knowledge of relations between benzodiazepines and serotonin by specifying the involvement of 5-HT1B receptors.	Benzodiazepines	55-70	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	121-127
1971720-7	1990	These results suggest that tranquillizing drugs of the benzodiazepines group, but not of other groups, interact with the 5-HT1B receptors; they add to the knowledge of relations between benzodiazepines and serotonin by specifying the involvement of 5-HT1B receptors.	Benzodiazepines	55-70	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	249-255
1971720-7	1990	These results suggest that tranquillizing drugs of the benzodiazepines group, but not of other groups, interact with the 5-HT1B receptors; they add to the knowledge of relations between benzodiazepines and serotonin by specifying the involvement of 5-HT1B receptors.	Benzodiazepines	186-201	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	121-127
2154488-1	1990	Testicular mitochondria were previously shown to contain an abundance of peripheral-type benzodiazepine recognition site(s)/receptor(s) (PBR).	Benzodiazepines	89-103	translocator protein	Homo sapiens	137-140
2299627-3	1990	Modifications previously found in the benzodiazepine antagonists to result in brain CCK/gastrin receptor selectivity were also incorporated to produce an aryl urea series of glutamic acid analogues.	Benzodiazepines	38-52	cholecystokinin	Homo sapiens	84-87
1970141-1	1990	Binding of benzodiazepines to the benzodiazepine gamma-aminobutyric acid (GABA) receptor-chloride channel complex has been shown to be altered by Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2).	Benzodiazepines	11-26	predicted gene 4924	Mus musculus	150-155
2299627-3	1990	Modifications previously found in the benzodiazepine antagonists to result in brain CCK/gastrin receptor selectivity were also incorporated to produce an aryl urea series of glutamic acid analogues.	Benzodiazepines	38-52	cholecystokinin B receptor	Homo sapiens	88-104
2154668-0	1990	A natural processing product of rat diazepam binding inhibitor, triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an alpha-helix, which allows discrimination between benzodiazepine binding site subtypes.	Benzodiazepines	187-201	diazepam binding inhibitor	Rattus norvegicus	36-62
2154668-0	1990	A natural processing product of rat diazepam binding inhibitor, triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an alpha-helix, which allows discrimination between benzodiazepine binding site subtypes.	Benzodiazepines	187-201	diazepam binding inhibitor	Rattus norvegicus	64-90
2154668-0	1990	A natural processing product of rat diazepam binding inhibitor, triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an alpha-helix, which allows discrimination between benzodiazepine binding site subtypes.	Benzodiazepines	187-201	diazepam binding inhibitor	Rattus norvegicus	92-118
2159126-2	1990	In rat brain DBI coexists with at least three different processing products and the members of this peptide family have been shown to displace benzodiazepines and beta carbolines from recognition sites located on the allosteric modulatory centers of GABAA receptors.	Benzodiazepines	143-158	diazepam binding inhibitor	Rattus norvegicus	13-16
2185430-1	1990	Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries.	Benzodiazepines	166-180	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	74-100
2185430-1	1990	Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries.	Benzodiazepines	166-180	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	102-105
2080757-1	1990	E6123 is a new member of the benzodiazepine class of PAF antagonists.	Benzodiazepines	29-43	patchy fur	Mus musculus	53-56
2351370-1	1990	An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms.	Benzodiazepines	57-72	cholecystokinin	Rattus norvegicus	22-37
2097287-0	1990	[Benzodiazepines as cytochrome P-450 and cytochrome b5 inductors in rat liver microsomes].	Benzodiazepines	1-16	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-36
2097287-0	1990	[Benzodiazepines as cytochrome P-450 and cytochrome b5 inductors in rat liver microsomes].	Benzodiazepines	1-16	cytochrome b5 type A	Rattus norvegicus	41-54
2097287-1	1990	Among the benzodiazepines tested (diazepam, oxazepam, clonazepam, nitrazepam and chlordiazepoxide ) chlordiazepoxide is the most potent inducer of cytochrome P-450, diazepam is a poor inducer, whereas clonazepam and nitrazepam do not possess a capacity to induce of cytochrome P-450.	Benzodiazepines	10-25	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	147-163
2351370-1	1990	An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms.	Benzodiazepines	57-72	cholecystokinin	Rattus norvegicus	39-42
2351370-1	1990	An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms.	Benzodiazepines	74-77	cholecystokinin	Rattus norvegicus	22-37
2351370-1	1990	An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms.	Benzodiazepines	74-77	cholecystokinin	Rattus norvegicus	39-42
2174491-3	1990	We have previously reported that the peripheral benzodiazepine ligands, Ro5-4864 and PK 11195, modulate prolactin-stimulated mitogenesis in the Nb2 cell(1).	Benzodiazepines	48-62	prolactin	Rattus norvegicus	104-113
2153212-4	1990	The benzodiazepines described in this study are simultaneously CCK-A and opioid receptor ligands.	Benzodiazepines	4-19	cholecystokinin	Rattus norvegicus	63-66
1691460-0	1990	Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain.	Benzodiazepines	50-64	diazepam binding inhibitor	Rattus norvegicus	72-92
2098668-4	1990	The robust increase in prolactin levels is less consistent with previously reported data on traditional benzodiazepines.	Benzodiazepines	104-119	prolactin	Homo sapiens	23-32
2153908-1	1990	Using [3H]flunitrazepam as a probe for the benzodiazepine-sensitive modulator site located on the gamma-aminobutyric acid (GABA)A receptor complex, we have investigated the cellular regulation of the GABAA receptor in neuronal cultures derived from embryonic chick brain.	Benzodiazepines	43-57	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	200-214
1691460-0	1990	Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain.	Benzodiazepines	50-64	diazepam binding inhibitor	Rattus norvegicus	94-97
1691460-1	1990	In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide.	Benzodiazepines	67-81	diazepam binding inhibitor	Rattus norvegicus	89-109
1691460-1	1990	In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide.	Benzodiazepines	67-81	diazepam binding inhibitor	Rattus norvegicus	111-114
33942407-2	2021	Whereas the role of the different GABAA receptor alpha-subunits in sleep regulation and in mediating the effect of benzodiazepines for treatment of insomnia is well-described, the beta-subunits are less studied.	Benzodiazepines	115-130	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	34-39
10871693-7	2000	Gene knockout studies of the role of GABA(A)alpha6 and GABA(A)gamma2 subunit genes in mice have demonstrated an essential role in the modulation of other GABA(A) subunit expression and the efficacy of benzodiazepine binding.	Benzodiazepines	201-215	tryptophanyl-tRNA synthetase 1	Homo sapiens	62-68
33780181-0	2021	Supramolecular Solvent Extraction-Gas Chromatography-Tandem Mass Spectrometry for Detection of Benzodiazepines in Urines.	Benzodiazepines	95-110	gastrin	Homo sapiens	34-37
33780181-1	2021	Abstract: Objective To establish a method using supramolecular solvent and gas chromatography-tandem mass spectrometry (GC-MS/MS) to analyze 9 benzodiazepines in urines.	Benzodiazepines	143-158	gastrin	Homo sapiens	75-78
26295909-8	2015	For the detection of benzodiazepines and their metabolites, an enzymatic hydrolysis was applied (beta-glucuronidase, pH 4.5, 50 C, 18h).	Benzodiazepines	21-36	glucuronidase beta	Homo sapiens	97-115
9021893-0	1997	Depression of early and late monosynaptic inhibitory postsynaptic potentials in hippocampal CA1 neurons following prolonged benzodiazepine administration: role of a reduction in Cl- driving force.	Benzodiazepines	124-138	carbonic anhydrase 1	Rattus norvegicus	92-95
9021893-9	1997	We conclude from these data that an impairment of GABAergic transmission in CA1 pyramidal neurons associated with the development of tolerance during chronic benzodiazepine treatment may be related to the regulation of both pre- and postsynaptic mechanisms at the GABA synapse.	Benzodiazepines	158-172	carbonic anhydrase 1	Rattus norvegicus	76-79
23799902-3	2013	TMN neurons express nine different subunits of the GABAA receptor (GABAA R) with three alpha- (alpha1, alpha2 and alpha5) and two gamma- (gamma1, gamma 2) subunits, which confer different pharmacologies of the benzodiazepine-binding site.	Benzodiazepines	210-224	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	51-65
23799902-3	2013	TMN neurons express nine different subunits of the GABAA receptor (GABAA R) with three alpha- (alpha1, alpha2 and alpha5) and two gamma- (gamma1, gamma 2) subunits, which confer different pharmacologies of the benzodiazepine-binding site.	Benzodiazepines	210-224	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	67-74
34848203-1	2022	Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess diverse central nervous system (CNS) pathologies in preclinical and clinical studies.	Benzodiazepines	64-78	translocator protein	Homo sapiens	0-27
34668419-3	2021	We recently described certain benzodiazepines as OGR1 activators capable of mediating both pro-contractile and pro-relaxant signaling in ASM cells.	Benzodiazepines	30-45	G protein-coupled receptor 68	Mus musculus	49-53
34856331-0	2022	Benzodiazepines safeguards nerve cells from the toxicity of lidocaine via miR-133a-3p/EGFR pathway.	Benzodiazepines	0-15	epidermal growth factor receptor	Rattus norvegicus	86-90
34856331-11	2022	Lidocaine downregulated miR-133a-3p RNA expression but facilitated EGFR mRNA expression, which was reversed after treated by benzodiazepines.	Benzodiazepines	125-140	epidermal growth factor receptor	Rattus norvegicus	67-71
34856331-13	2022	Furthermore, miR-133a-3p inhibitor and overexpressed EGFR transfection both restrained the decreased PC12 cell viability and prompted cell apoptosis caused by benzodiazepines.	Benzodiazepines	159-174	epidermal growth factor receptor	Rattus norvegicus	53-57
34856331-14	2022	CONCLUSION: Benzodiazepines restrained lidocaine-induced toxicity in PC12 cells which secured viability and reduced apoptosis via miR-133a-3p/EGFR pathway.	Benzodiazepines	12-27	epidermal growth factor receptor	Rattus norvegicus	142-146
34807524-1	2022	AIM: To describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT-I).	Benzodiazepines	126-140	activation induced cytidine deaminase	Homo sapiens	65-68
34807524-1	2022	AIM: To describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT-I).	Benzodiazepines	142-145	activation induced cytidine deaminase	Homo sapiens	65-68
34807524-1	2022	AIM: To describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT-I).	Benzodiazepines	151-165	activation induced cytidine deaminase	Homo sapiens	65-68
34791657-3	2022	KCC2 functional downregulation is a potential contributor to benzodiazepine resistance.	Benzodiazepines	61-75	solute carrier family 12 member 5	Homo sapiens	0-4
34848203-1	2022	Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess diverse central nervous system (CNS) pathologies in preclinical and clinical studies.	Benzodiazepines	64-78	translocator protein	Homo sapiens	29-33
34284042-9	2021	Furthermore, alpha5-NAM inhibition of the GABAAR tonic current in mature neurons is maintained after 2-day alpha5-NAM treatment, suggesting reduced tolerance liability, in contrast to other clinically relevant GABAAR-targeting drugs such as benzodiazepines.	Benzodiazepines	241-256	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	210-216
34565656-1	2021	Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI).	Benzodiazepines	114-128	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	183-209
34565656-1	2021	Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI).	Benzodiazepines	114-128	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	211-214
34543014-1	2021	Casein tryptic hydrolysate (CTH) has been proven to possess stress-relieving and sleep-enhancing effects, but only one decapeptide YLGYLEQLLR (alpha-CZP) in CTH was reported to exhibit affinity for the benzodiazepine site of a GABAA receptor (GABAAR).	Benzodiazepines	202-216	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	243-249
34392107-3	2021	However, some unexplained anomalous behaviour of alpha-CZP includes 1) 1000 times less affinity for BZD site on GABAA receptor in vitro conditions, whereas in vivo it showed 10-fold increased affinity when compared to diazepam; 2) anxiolytic effects were observed only in stressed conditions and 3) unlike diazepam, it failed to exhibit dependence or habituation.	Benzodiazepines	100-103	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	112-117
34154424-5	2021	We performed a thermal shift assay (TSA)-based high-throughput screening (HTS) with 410,000 compounds and identified a novel benzodiazepine-based SMYD3 inhibitor series.	Benzodiazepines	125-139	SET and MYND domain containing 3	Homo sapiens	146-151
34388602-1	2021	Midazolam (MDZ) is a short-acting benzodiazepine with rapid onset of action, which is metabolized by CYP3A isoenzymes to two hydroxylated metabolites, 1"-hydroxymidazolam and 4-hydroxymidazolam.	Benzodiazepines	34-48	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	101-106
34254805-1	2021	Translocator protein 18 kDa (TSPO or peripheral-type benzodiazepine receptor (PBR)) was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions.	Benzodiazepines	134-148	translocator protein	Homo sapiens	0-27
34254805-1	2021	Translocator protein 18 kDa (TSPO or peripheral-type benzodiazepine receptor (PBR)) was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions.	Benzodiazepines	134-148	translocator protein	Homo sapiens	29-33
34254805-1	2021	Translocator protein 18 kDa (TSPO or peripheral-type benzodiazepine receptor (PBR)) was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions.	Benzodiazepines	134-148	translocator protein	Homo sapiens	37-76
34254805-1	2021	Translocator protein 18 kDa (TSPO or peripheral-type benzodiazepine receptor (PBR)) was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions.	Benzodiazepines	134-148	translocator protein	Homo sapiens	78-81
34232302-1	2021	Importance: Extremely preterm (EP) infants frequently receive opioids and/or benzodiazepines, but these drugs" association with neurodevelopmental outcomes is poorly understood.	Benzodiazepines	77-92	epiregulin	Homo sapiens	31-33
34232302-2	2021	Objectives: To describe the use of opioids and benzodiazepines in EP infants during neonatal intensive care unit (NICU) hospitalization and to explore these drugs" association with neurodevelopmental outcomes at 2 years" corrected age.	Benzodiazepines	47-62	epiregulin	Homo sapiens	66-68
34101790-8	2021	Pre-operative benzodiazepine or anticholinergic treatments were also associated to a drop in MoCA scores (p=0.006).	Benzodiazepines	14-28	dedicator of cytokinesis 3	Homo sapiens	93-97
34079604-8	2021	Conclusions: Olanzapine, benzodiazepine, and PRN benzodiazepine use were associated with longer time until patients with dementia and agitation were considered ready for discharge.	Benzodiazepines	49-63	cytosolic iron-sulfur assembly component 3	Homo sapiens	45-48
34084316-10	2021	In addition, benzodiazepine receptor agonists improve pancreatic beta-cell functions through GABA dependent pathway or through modulation of pancreatic adenosine and glucagon-like peptide (GLP-1).	Benzodiazepines	13-27	glucagon like peptide 1 receptor	Homo sapiens	189-194
34183455-9	2021	Median time (p25-p75) of administration of first-line AED (BZD) and second-line AED (non-BZD) was 11 (8-15) min and 30 (22-35) min, respectively.	Benzodiazepines	59-62	tubulin polymerization promoting protein	Homo sapiens	13-16
34183455-9	2021	Median time (p25-p75) of administration of first-line AED (BZD) and second-line AED (non-BZD) was 11 (8-15) min and 30 (22-35) min, respectively.	Benzodiazepines	59-62	PC4 and SFRS1 interacting protein 1	Homo sapiens	17-20
35633443-10	2022	Also, upregulation of GABRA6 gene in ECTs could underlie benzodiazepine resistance in these patients.	Benzodiazepines	57-71	gamma-aminobutyric acid type A receptor subunit alpha6	Homo sapiens	22-28
35351776-0	2022	Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs .	Benzodiazepines	45-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-25
35351776-6	2022	However, the canine CYP2B11 appreciably contributes to the hydroxylation of benzodiazepine except for APZ 4-hydroxylation.	Benzodiazepines	76-90	cytochrome P450 2B11	Canis lupus familiaris	20-27
35397116-8	2022	Co-administration of opioid with benzodiazepine versus no opioid was 11% lower in period 2 and 34% lower in period 3 after adjusting for patient level covariates.	Benzodiazepines	33-47	period circadian regulator 2	Homo sapiens	82-90
35471917-9	2022	CONCLUSION: These results suggest that genotyping for common CYP3A variants might have the potential to guide benzodiazepine withdrawal treatment.	Benzodiazepines	110-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-66
35474395-10	2022	The DID analysis revealed that benzodiazepine prescription among victims significantly increased immediately after the disaster (adjusted ratio of odds ratios (ROR) 1.07: 95% confidence interval 1.05-1.11), and the effect of the disaster persisted even 1 year after the disaster (adjusted ROR 1.2: 95% confidence interval 1.16-1.24).	Benzodiazepines	31-45	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	160-163
35474395-10	2022	The DID analysis revealed that benzodiazepine prescription among victims significantly increased immediately after the disaster (adjusted ratio of odds ratios (ROR) 1.07: 95% confidence interval 1.05-1.11), and the effect of the disaster persisted even 1 year after the disaster (adjusted ROR 1.2: 95% confidence interval 1.16-1.24).	Benzodiazepines	31-45	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	289-294
35579344-0	2022	Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.	Benzodiazepines	0-14	arginine vasopressin receptor 2	Mus musculus	37-60
35579344-2	2022	Because the vasopressin V2 receptor (V2R) regulates intracellular cAMP levels in kidneys, a series of benzodiazepine derivatives were developed targeting the V2R.	Benzodiazepines	102-116	arginine vasopressin receptor 2	Mus musculus	12-35
35579344-2	2022	Because the vasopressin V2 receptor (V2R) regulates intracellular cAMP levels in kidneys, a series of benzodiazepine derivatives were developed targeting the V2R.	Benzodiazepines	102-116	arginine vasopressin receptor 2	Mus musculus	37-40
35579344-2	2022	Because the vasopressin V2 receptor (V2R) regulates intracellular cAMP levels in kidneys, a series of benzodiazepine derivatives were developed targeting the V2R.	Benzodiazepines	102-116	arginine vasopressin receptor 2	Mus musculus	158-161
35444539-4	2022	Originally, TSPO was identified as a binding site for benzodiazepines in the periphery.	Benzodiazepines	54-69	translocator protein	Homo sapiens	12-16
35365746-0	2022	A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.	Benzodiazepines	2-16	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	33-38
35365746-3	2022	The benzodiazepine derivative (R)-L3 potently activates Kv7.1 channels and shortens action potential duration, thus may represent a starting point for drug development.	Benzodiazepines	4-18	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	56-61
35500899-6	2022	Insomniacs using benzodiazepine showed a decrease of executive function in Trail Making Test A than drug-free insomniacs and controls (0.73+-0.66 vs. 1.27+-0.38 vs. 1.09+-0.47, p<0.001) and in categorical fluency than drug-free insomniacs (-0.01+-0.99 vs. 1.26+-0.97, p=0.002).	Benzodiazepines	17-31	TNF superfamily member 10	Homo sapiens	75-80
35229939-5	2022	Within the AUD group, transferrin saturation significantly predicted withdrawal symptoms (CIWA-Ar) and cumulative dose of benzodiazepine treatment during the first week of detoxification, which is an indicator of withdrawal severity.	Benzodiazepines	122-136	transferrin	Homo sapiens	22-33
2514008-4	1989	The activation of c-fos is not prevented by even high doses of benzodiazepines but is effectively reduced by the N-methyl-D-aspartate (glutamate) receptor antagonist ketamine.	Benzodiazepines	63-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
35202484-2	2022	Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam.	Benzodiazepines	187-201	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	29-35
35191968-1	2022	Importance: Alcohol withdrawal syndrome (AWS) is a common inpatient diagnosis managed primarily with benzodiazepines.	Benzodiazepines	101-116	jagged canonical Notch ligand 1	Homo sapiens	41-44
35191968-3	2022	Objective: To evaluate changes in outcomes after implementation of a benzodiazepine-sparing AWS inpatient order set that included adjunctive therapies (eg, gabapentin, valproic acid, clonidine, and dexmedetomidine).	Benzodiazepines	69-83	jagged canonical Notch ligand 1	Homo sapiens	92-95
35191968-6	2022	Exposures: Implementation of the benzodiazepine-sparing AWS order set on October 1, 2018.	Benzodiazepines	33-47	jagged canonical Notch ligand 1	Homo sapiens	56-59
35191968-13	2022	Conclusions and Relevance: This study found that implementation of a benzodiazepine-sparing AWS order set was associated with decreased use of benzodiazepines and favorable trends in outcomes.	Benzodiazepines	69-83	jagged canonical Notch ligand 1	Homo sapiens	92-95
35191968-13	2022	Conclusions and Relevance: This study found that implementation of a benzodiazepine-sparing AWS order set was associated with decreased use of benzodiazepines and favorable trends in outcomes.	Benzodiazepines	143-158	jagged canonical Notch ligand 1	Homo sapiens	92-95
2555358-1	1989	This report describes the cloning of a full length cDNA encoding PKBS, a protein of approximately 17 kDa associated with peripheral-type benzodiazepine binding sites.	Benzodiazepines	137-151	translocator protein	Rattus norvegicus	65-69
2555358-6	1989	Northern analysis with this PKBS cDNA probe in different rat tissues revealed one RNA species of approximately 850 nucleotides exhibiting relative abundances qualitatively comparable with the densities of peripheral-type benzodiazepine binding sites in each tissue.	Benzodiazepines	221-235	translocator protein	Rattus norvegicus	28-32
2555677-1	1989	Chronic benzodiazepine administration has been reported to decrease gamma-aminobutyric acidA (GABAA) receptor function in animals and may alter benzodiazepine binding in neuronal cultures.	Benzodiazepines	8-22	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	68-109
2555358-11	1989	These studies suggest that PKBS comprises binding domains for benzodiazepines and isoquinoline carboxamides and hence is apparently responsible for the manifestation of peripheral-type benzodiazepine recognition sites.	Benzodiazepines	62-77	translocator protein	Rattus norvegicus	27-31
2555358-11	1989	These studies suggest that PKBS comprises binding domains for benzodiazepines and isoquinoline carboxamides and hence is apparently responsible for the manifestation of peripheral-type benzodiazepine recognition sites.	Benzodiazepines	62-76	translocator protein	Rattus norvegicus	27-31
2555030-3	1989	The GABAA receptor complex, the presumed site of benzodiazepine action, was altered in adult chickens previously exposed to lorazepam for 10 days in ovo.	Benzodiazepines	49-63	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	4-18
2562066-0	1989	The responsiveness of central benzodiazepine and GABA(A) receptors in vasopressin and spontaneously hypertensive rats.	Benzodiazepines	30-44	arginine vasopressin	Rattus norvegicus	70-81
2533078-1	1989	We used an in vitro radioligand receptor binding assay with rat cerebral cortex, hippocampus and striatum membrane preparations to show that 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554) had much higher affinity for 5-HT1A recognition sites than for 5-HT1-non-A, 5-HT2, benzodiazepine, dopamine D-2 and alpha 2-adrenergic recognition sites.	Benzodiazepines	293-307	5-hydroxytryptamine receptor 1A	Rattus norvegicus	239-245
2769267-4	1989	Synthetic TTN injected intracerebroventricularly into rats induces a proconflict activity (IC50 0.8 nmol/rat) that is prevented by the specific "peripheral" benzodiazepine (BZ) receptor antagonist isoquinoline carboxamide, PK 11195, but not by the "central" BZ receptor antagonist imidazobenzodiazepine, flumazenil.	Benzodiazepines	157-171	diazepam binding inhibitor	Rattus norvegicus	10-13
2769267-4	1989	Synthetic TTN injected intracerebroventricularly into rats induces a proconflict activity (IC50 0.8 nmol/rat) that is prevented by the specific "peripheral" benzodiazepine (BZ) receptor antagonist isoquinoline carboxamide, PK 11195, but not by the "central" BZ receptor antagonist imidazobenzodiazepine, flumazenil.	Benzodiazepines	173-175	diazepam binding inhibitor	Rattus norvegicus	10-13
2769267-7	1989	These data suggest that TTN, a natural DBI processing product acting at "Ro 5-4864 preferring" BZ binding site subtypes, might function as a putative neuromodulator of specific GABAA receptor-mediated effects.	Benzodiazepines	95-97	diazepam binding inhibitor	Rattus norvegicus	24-27
2769267-7	1989	These data suggest that TTN, a natural DBI processing product acting at "Ro 5-4864 preferring" BZ binding site subtypes, might function as a putative neuromodulator of specific GABAA receptor-mediated effects.	Benzodiazepines	95-97	diazepam binding inhibitor	Rattus norvegicus	39-42
2561970-3	1989	The gamma 2 subunit is the rat homolog of the human gamma 2 subunit recently shown to be important for benzodiazepine pharmacology.	Benzodiazepines	103-117	crystallin, gamma E	Rattus norvegicus	4-11
2561970-3	1989	The gamma 2 subunit is the rat homolog of the human gamma 2 subunit recently shown to be important for benzodiazepine pharmacology.	Benzodiazepines	103-117	crystallin, gamma E	Rattus norvegicus	52-59
2549847-1	1989	The neuropeptide diazepam binding inhibitor (DBI) is an endogeneous allosteric modulator of gamma-aminobutyric acid (GABA) receptors at the benzodiazepine recognition site.	Benzodiazepines	140-154	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	17-43
2550260-8	1989	Mast cells have high contents of calmodulin (602 +/- 20 ng/10(6) cells), and benzodiazepines inhibited calmodulin.	Benzodiazepines	77-92	calmodulin 1	Rattus norvegicus	103-113
2550260-9	1989	The benzodiazepine inhibitory effects on the serotonin release induced by A23187 seemed to be partly due to their calmodulin-inhibiting activities.	Benzodiazepines	4-18	calmodulin 1	Rattus norvegicus	114-124
2473653-0	1989	Benzodiazepine analogues L365,260 and L364,718 as gastrin and pancreatic CCK receptor antagonists.	Benzodiazepines	0-14	gastrin	Cavia porcellus	50-57
2473653-0	1989	Benzodiazepine analogues L365,260 and L364,718 as gastrin and pancreatic CCK receptor antagonists.	Benzodiazepines	0-14	cholecystokinin	Cavia porcellus	73-76
2549847-1	1989	The neuropeptide diazepam binding inhibitor (DBI) is an endogeneous allosteric modulator of gamma-aminobutyric acid (GABA) receptors at the benzodiazepine recognition site.	Benzodiazepines	140-154	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	45-48
2554616-1	1989	The paper deals with analysis of the influence of blockade of separate components of benzodiazepine-GABA-ionophore complex on the recovery of memory trace amnesia under GABA-A and GABA-B receptors activation in the experiments with conditioned reaction of passive avoidance of mice.	Benzodiazepines	85-99	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	169-175
2554616-7	1989	The obtained data testify that activation of GABA-A and GABA-B receptors changes the amnesia development and correction of amnesia memory trace by the blockade of separate components of benzodiazepine-GABA-ionophore complex.	Benzodiazepines	186-200	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	45-51
2542077-10	1989	BDZ-evoked WDS may relate to the unique predominance of BDZ II and 5-HT1A receptors in the hippocampus, an important site for WDS, but 5-HT1A agonists appear to modulate WDS by opposing pharmacologic actions rather than by direct receptor antagonism.	Benzodiazepines	0-3	5-hydroxytryptamine receptor 1A	Rattus norvegicus	67-73
2720404-0	1989	Cholecystokinin antagonism by anthramycin, a benzodiazepine antibiotic, in the central nervous system in mice.	Benzodiazepines	45-59	cholecystokinin	Mus musculus	0-15
2927661-1	1989	Diazepam binding inhibitor (DBI) is a novel neuropeptide purified from rat, cow, and human brain that allosterically modulates GABAergic transmission by binding to benzodiazepine (BDZ)-recognition sites.	Benzodiazepines	164-178	diazepam binding inhibitor	Rattus norvegicus	0-32
2571169-1	1989	Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2) can increase GABA-stimulated benzodiazepine binding in brain tissue can block the hypothermia induced by several other compounds.	Benzodiazepines	89-103	predicted gene 4924	Mus musculus	4-9
2571169-1	1989	Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2) can increase GABA-stimulated benzodiazepine binding in brain tissue can block the hypothermia induced by several other compounds.	Benzodiazepines	89-103	predicted gene 4924	Mus musculus	36-41
2571169-4	1989	The results indicate that the interaction of Tyr-MIF-1 and MIF-1 with benzodiazepines does not involve thermoregulation.	Benzodiazepines	70-85	predicted gene 4924	Mus musculus	49-54
2571169-4	1989	The results indicate that the interaction of Tyr-MIF-1 and MIF-1 with benzodiazepines does not involve thermoregulation.	Benzodiazepines	70-85	predicted gene 4924	Mus musculus	59-64
2553044-0	1989	Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary.	Benzodiazepines	38-52	corticotropin releasing hormone	Rattus norvegicus	66-96
2553044-1	1989	We examined the effects of chronic treatment with antidepressants (imipramine or desipramine) or benzodiazepines (diazepam, alprazolam, or adinazolam) on modulation of corticotropin-releasing-factor (CRF) receptors in discrete areas of rat brain and in anterior pituitary.	Benzodiazepines	97-112	corticotropin releasing hormone	Rattus norvegicus	168-198
2927661-1	1989	Diazepam binding inhibitor (DBI) is a novel neuropeptide purified from rat, cow, and human brain that allosterically modulates GABAergic transmission by binding to benzodiazepine (BDZ)-recognition sites.	Benzodiazepines	180-183	diazepam binding inhibitor	Rattus norvegicus	0-32
2538195-0	1989	The interaction of benzodiazepines with thyrotropin-releasing hormone receptors on clonal pituitary cells.	Benzodiazepines	19-34	thyrotropin releasing hormone	Rattus norvegicus	40-69
2538195-2	1989	Seven benzodiazepines were investigated for their ability to interact with receptors for thyrotropin-releasing hormone (TRH) on GH3 and GH4C1 pituitary tumour cells.	Benzodiazepines	6-21	thyrotropin releasing hormone	Rattus norvegicus	89-118
2538195-2	1989	Seven benzodiazepines were investigated for their ability to interact with receptors for thyrotropin-releasing hormone (TRH) on GH3 and GH4C1 pituitary tumour cells.	Benzodiazepines	6-21	thyrotropin releasing hormone	Rattus norvegicus	120-123
2848124-2	1988	Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effective ligands selective for peripheral (CCK-A) receptors, with binding affinities approaching or equaling that of the natural ligand CCK-8.	Benzodiazepines	59-74	cholecystokinin A receptor	Homo sapiens	166-171
2576913-0	1989	PAF-acether-induced mortality in mice: protection by benzodiazepines.	Benzodiazepines	53-68	patchy fur	Mus musculus	0-3
2576913-6	1989	Thus PAF-induced death in mice represents a useful model of systemic anaphylaxis; moreover, studies of benzodiazepine-related compounds may be interesting for investigating the mechanisms of the biological actions of PAF.	Benzodiazepines	103-117	patchy fur	Mus musculus	217-220
2535706-2	1989	In light of the recent demonstration of the mitochondrial localization of this receptor and its potential role in intermediary metabolism, we investigated the relationship between the benzodiazepines and the enzyme pyruvate dehydrogenase (PDH), a component of the mitochondrial membrane.	Benzodiazepines	184-199	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	215-237
2535706-2	1989	In light of the recent demonstration of the mitochondrial localization of this receptor and its potential role in intermediary metabolism, we investigated the relationship between the benzodiazepines and the enzyme pyruvate dehydrogenase (PDH), a component of the mitochondrial membrane.	Benzodiazepines	184-199	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	239-242
2567038-8	1989	In animal "conflict models" for anxiety, 5-HT-2-receptor antagonists are active, although they are weaker than the benzodiazepines.	Benzodiazepines	115-130	5-hydroxytryptamine receptor 2A	Homo sapiens	41-56
2544930-1	1989	The present study investigates the inhibitory effect of the novel potent benzodiazepine-related CCK-antagonist L-364,718 on pancreatic growth in the rat induced by chronic administration of caerulein and bombesin-like peptides.	Benzodiazepines	73-87	cholecystokinin	Rattus norvegicus	96-99
2905831-7	1988	For the benzodiazepine preparations, the psychic and neurologic ADR occurred at about the same rate as for the neuroleptic drugs studied, whereas "other ADR" related to benzodiazepines were observed in only 0.04% of treatments.	Benzodiazepines	169-184	aldo-keto reductase family 1 member B	Homo sapiens	153-157
2464483-4	1989	In Fp1, C3 and O1, PC-2, with a bipolarity of alpha 2 versus beta 1 and beta 2 in the wave percent-time in loading profile, could be a component showing characteristic changes common to the 2 benzodiazepines.	Benzodiazepines	192-207	chromobox 4	Homo sapiens	19-23
2550216-3	1989	Phenobarbital (PB) and the benzodiazepines (BZDs), diazepam (DZP), clonazepam (CZP), and lorazepam (LZP), also reduced SRF, but only at supratherapeutic free serum concentrations achieved in treatment of generalized tonic-clonic status epilepticus.	Benzodiazepines	27-42	serum response factor	Mus musculus	119-122
2550216-3	1989	Phenobarbital (PB) and the benzodiazepines (BZDs), diazepam (DZP), clonazepam (CZP), and lorazepam (LZP), also reduced SRF, but only at supratherapeutic free serum concentrations achieved in treatment of generalized tonic-clonic status epilepticus.	Benzodiazepines	44-48	serum response factor	Mus musculus	119-122
2552350-0	1989	Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro.	Benzodiazepines	13-28	proopiomelanocortin	Homo sapiens	105-141
2552350-6	1989	Only central-type benzodiazepine binding site agonists such as clonazepam (10(-4) M) modified alpha-melanocyte-stimulating hormone release.	Benzodiazepines	18-32	proopiomelanocortin	Homo sapiens	94-130
2552484-8	1989	P300 also seems to be useful to investigate the pharmacological effects of benzodiazepines.	Benzodiazepines	75-90	E1A binding protein p300	Homo sapiens	0-4
2848124-2	1988	Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effective ligands selective for peripheral (CCK-A) receptors, with binding affinities approaching or equaling that of the natural ligand CCK-8.	Benzodiazepines	59-74	cholecystokinin	Homo sapiens	166-169
3183966-1	1988	The neuronal manifestations and mechanisms of sedative-anticonvulsant (benzodiazepine) drug withdrawal have been investigated in the CA1 region of hippocampal slices prepared from rats administered clonazepam for 1 month.	Benzodiazepines	71-85	carbonic anhydrase 1	Rattus norvegicus	133-136
2852215-2	1988	Diazepam binding inhibitor (DBI), recently isolated from rat and human brain, has been proposed as an endogenous ligand at the benzodiazepine receptor.	Benzodiazepines	127-141	diazepam binding inhibitor	Rattus norvegicus	0-26
2852215-2	1988	Diazepam binding inhibitor (DBI), recently isolated from rat and human brain, has been proposed as an endogenous ligand at the benzodiazepine receptor.	Benzodiazepines	127-141	diazepam binding inhibitor	Rattus norvegicus	28-31
2908009-1	1988	The possibility of a linkage between endogenous peptides and the GABA-benzodiazepine system has been greatly strengthened by reports that the brain peptides MIF-1(Pro-Leu-Gly-NH2) and Tyr-MIF-1(Tyr-Pro-Leu-Gly-NH2) augment GABA-stimulated benzodiazepine binding.	Benzodiazepines	70-84	predicted gene 4924	Mus musculus	157-162
2908009-1	1988	The possibility of a linkage between endogenous peptides and the GABA-benzodiazepine system has been greatly strengthened by reports that the brain peptides MIF-1(Pro-Leu-Gly-NH2) and Tyr-MIF-1(Tyr-Pro-Leu-Gly-NH2) augment GABA-stimulated benzodiazepine binding.	Benzodiazepines	70-84	predicted gene 4924	Mus musculus	188-193
2908009-1	1988	The possibility of a linkage between endogenous peptides and the GABA-benzodiazepine system has been greatly strengthened by reports that the brain peptides MIF-1(Pro-Leu-Gly-NH2) and Tyr-MIF-1(Tyr-Pro-Leu-Gly-NH2) augment GABA-stimulated benzodiazepine binding.	Benzodiazepines	239-253	predicted gene 4924	Mus musculus	157-162
2908009-1	1988	The possibility of a linkage between endogenous peptides and the GABA-benzodiazepine system has been greatly strengthened by reports that the brain peptides MIF-1(Pro-Leu-Gly-NH2) and Tyr-MIF-1(Tyr-Pro-Leu-Gly-NH2) augment GABA-stimulated benzodiazepine binding.	Benzodiazepines	239-253	predicted gene 4924	Mus musculus	188-193
2908009-4	1988	These results demonstrate the specificity of the effects of MIF-1 and Tyr-MIF-1 on GABA-stimulated benzodiazepine binding.	Benzodiazepines	99-113	predicted gene 4924	Mus musculus	60-65
2908009-4	1988	These results demonstrate the specificity of the effects of MIF-1 and Tyr-MIF-1 on GABA-stimulated benzodiazepine binding.	Benzodiazepines	99-113	predicted gene 4924	Mus musculus	74-79
3055361-2	1988	Differing substantially both in its mode of action and in the clinical expression of its action from agents such as barbiturates and benzodiazepines, it would seem to operate chiefly via the 5-HT1A subtype of serotonin receptor.	Benzodiazepines	133-148	5-hydroxytryptamine receptor 1A	Homo sapiens	191-197
2908362-4	1988	The results suggest that chlordiazepoxide (and possibly other benzodiazepines) acts on two subgroups of benzodiazepine receptors, named BRI (high affinity) and BR2 (low affinity), while tofisopam acts specifically on BRI receptors.	Benzodiazepines	62-77	integral membrane protein 2B	Rattus norvegicus	136-139
2907488-6	1988	pretreatment with the benzodiazepine antagonists Ro 15-1788 (0.18-3.0 mg/kg) or AHR-11797 (1.0-5.6 mg/kg); in this regard, AHR-11797 was less potent than Ro 15-1788.	Benzodiazepines	22-36	aryl hydrocarbon receptor	Homo sapiens	123-126
2897649-5	1988	Benzodiazepine binding was significantly decreased in the cerebral cortex and increased in the CA1 subfield of the hippocampus.	Benzodiazepines	0-14	carbonic anhydrase 1	Mus musculus	95-98
3147122-9	1988	These results suggest that the central analgesic effects of the FSH-suppressing steroid, 3A4P, arise via benzodiazepine--GABA--opiate mechanisms and calcium channels.	Benzodiazepines	105-119	follicle stimulating hormone beta	Mus musculus	64-67
3054318-0	1988	Modification of the EMIT tox benzodiazepine assay for screening of alprazolam in serum.	Benzodiazepines	29-43	thymocyte selection associated high mobility group box	Homo sapiens	25-28
3054318-2	1988	The objective of this study was to optimize the reactivity of the EMIT tox serum benzodiazepine assay for toxicologic screening of alprazolam.	Benzodiazepines	81-95	thymocyte selection associated high mobility group box	Homo sapiens	71-74
2845442-4	1988	Thus, the inhibition of TRH receptor binding by the triazolobenzodiazepines is similar to that produced by other types of benzodiazepines.	Benzodiazepines	60-75	thyrotropin releasing hormone receptor	Homo sapiens	24-36
3413112-1	1988	We have used in situ chromosome hybridization and human-mouse somatic cell hybrids to map the gene(s) for human diazepam binding inhibitor (DBI), an endogenous putative modulator of the gamma-aminobutyric acid receptor acting at the allosteric regulatory center of this receptor that includes the benzodiazepine recognition site.	Benzodiazepines	297-311	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	112-138
3413112-1	1988	We have used in situ chromosome hybridization and human-mouse somatic cell hybrids to map the gene(s) for human diazepam binding inhibitor (DBI), an endogenous putative modulator of the gamma-aminobutyric acid receptor acting at the allosteric regulatory center of this receptor that includes the benzodiazepine recognition site.	Benzodiazepines	297-311	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	140-143
3413133-6	1988	In situ hybridizations also revealed high levels of DBI mRNA in the posterior lobe of the pituitary gland, liver, and germinal center of the white pulp of spleen, all tissues that are rich in peripheral benzodiazepine binding sites.	Benzodiazepines	203-217	diazepam binding inhibitor	Rattus norvegicus	52-55
3171600-2	1988	A single dose of TNF (30 micrograms/kg) to rats significantly reduced the plasma clearance of antipyrine and diazepam by about 30% and 25%, respectively; this resulted in concomitant prolongation of the elimination half-life (t1/2) of the two drugs, although of borderline significance for the benzodiazepine.	Benzodiazepines	294-308	tumor necrosis factor-like	Rattus norvegicus	17-20
3125983-3	1988	There is a dramatic increase in the FSE2 binding complex when Fos levels are induced with serum, benzodiazepine, and nerve growth factor or are expressed from a v-fos gene.	Benzodiazepines	97-111	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-65
3378169-6	1988	Octadecaneuropeptide (ODN), a putative neuroregulatory peptide for benzodiazepine recognition sites, was present in approximately 28% of all neurons.	Benzodiazepines	67-81	diazepam binding inhibitor	Rattus norvegicus	0-20
3378169-6	1988	Octadecaneuropeptide (ODN), a putative neuroregulatory peptide for benzodiazepine recognition sites, was present in approximately 28% of all neurons.	Benzodiazepines	67-81	diazepam binding inhibitor	Rattus norvegicus	22-25
3132026-2	1988	It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands.	Benzodiazepines	29-44	translocator protein	Homo sapiens	153-192
3125983-3	1988	There is a dramatic increase in the FSE2 binding complex when Fos levels are induced with serum, benzodiazepine, and nerve growth factor or are expressed from a v-fos gene.	Benzodiazepines	97-111	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-166
2450203-8	1988	We propose that the limitation of SRF may contribute to the efficacy of BDZs against generalized tonic-clonic seizures and status epilepticus.	Benzodiazepines	72-76	serum response factor	Mus musculus	34-37
3335854-0	1988	Characterization of a cytosolic protein (P36) isolated from pig brain by benzodiazepine-affinity chromatography.	Benzodiazepines	73-87	annexin A2	Sus scrofa	41-44
3335854-1	1988	Benzodiazepine-affinity chromatography, on a column of 1012S-Sepharose, resulted in the detection and purification of a binding protein (P36) from the cytosolic fraction of pig cerebral cortex.	Benzodiazepines	0-14	annexin A2	Sus scrofa	137-140
2450203-1	1988	Effects of benzodiazepines (BDZs) and beta carbolines (beta CCs) on sustained repetitive firing at high frequency (SRF) of action potentials of mouse spinal cord neurons in cell culture were examined using intracellular recording techniques.	Benzodiazepines	11-26	serum response factor	Mus musculus	115-118
3128805-0	1988	Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test.	Benzodiazepines	88-102	corticotropin releasing hormone	Rattus norvegicus	0-30
2450203-3	1988	Limitation of SRF was produced by the anticonvulsant BDZs (diazepam, clonazepam, nitrazepam and lorazepam) at low to mid nanomolar concentrations, by a convulsant BDZ which does not bind to high affinity BDZ receptors (Ro 5-4864) at high nanomolar concentrations and by a BDZ receptor weak partial agonist (Ro 15-1788) at micromolar concentrations.	Benzodiazepines	53-57	serum response factor	Mus musculus	14-17
2450203-3	1988	Limitation of SRF was produced by the anticonvulsant BDZs (diazepam, clonazepam, nitrazepam and lorazepam) at low to mid nanomolar concentrations, by a convulsant BDZ which does not bind to high affinity BDZ receptors (Ro 5-4864) at high nanomolar concentrations and by a BDZ receptor weak partial agonist (Ro 15-1788) at micromolar concentrations.	Benzodiazepines	53-56	serum response factor	Mus musculus	14-17
2848549-1	1988	Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases.	Benzodiazepines	16-30	choline O-acetyltransferase	Homo sapiens	137-141
2848549-1	1988	Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases.	Benzodiazepines	16-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-167
2848549-1	1988	Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases.	Benzodiazepines	16-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
2906158-11	1988	The results suggest that in the human brain 3H-2oxoquaz binds with high affinity to a subpopulation of BZD recognition sites (Type I sites) which are functionally linked to the GABA receptor and the chloride ionophore.	Benzodiazepines	103-106	GABA type A receptor-associated protein	Homo sapiens	177-190
3336017-5	1988	In vivo activity of selected compounds in mice is presented and the structure/activity profile of this class of benzodiazepines as CCK antagonists is discussed.	Benzodiazepines	112-127	cholecystokinin	Mus musculus	131-134
2448839-0	1988	High-affinity benzodiazepine binding sites on rat peritoneal mast cells and RBL-1 cells: binding characteristics and effects on granule secretion.	Benzodiazepines	14-28	RB transcriptional corepressor like 1	Rattus norvegicus	76-81
2906441-0	1988	Plasma prolactin response to gonadotropin-releasing hormone during benzodiazepine treatment.	Benzodiazepines	67-81	prolactin	Homo sapiens	7-16
2906441-0	1988	Plasma prolactin response to gonadotropin-releasing hormone during benzodiazepine treatment.	Benzodiazepines	67-81	gonadotropin releasing hormone 1	Homo sapiens	29-59
2906441-4	1988	In six premenopausal women treated with benzodiazepines, basal PRL concentrations were not influenced by the drug in four subjects (range 4.0-15.7 ng/ml) and were slightly elevated in two subjects (23 and 30 ng/ml).	Benzodiazepines	40-55	prolactin	Homo sapiens	63-66
2908516-13	1988	Blunting of the growth hormone response to diazepam was the most sensitive and reliable method of detecting tolerance to the benzodiazepines.	Benzodiazepines	125-140	growth hormone 1	Homo sapiens	16-30
2822333-5	1987	Therefore, benzodiazepines with high affinity for the benzodiazepine receptor sites in human brain tend to exhibit prolonged half-lives of elimination from the CSF which correlate with the prolonged duration of clinical and pharmacological effects and lower therapeutic doses of these drugs in vivo.	Benzodiazepines	11-26	colony stimulating factor 2	Homo sapiens	160-163
3689451-1	1987	The benzodiazepine [3H]Ro 5-4864 bound specifically and saturably to an apparently homogenous, univalent species of binding site on the calmodulin molecule with an associated equilibrium dissociation rate constant (Kd) of 644 +/- 121 nM.	Benzodiazepines	4-18	calmodulin 1	Homo sapiens	136-146
3689451-4	1987	Only benzodiazepine compounds (chlordiazepoxide, diazepam and Ro 5-4864) inhibited [3H]Ro 5-4864 binding to calmodulin with inhibitory equilibrium dissociation constants (Ki) less than 10 microM.	Benzodiazepines	5-19	calmodulin 1	Homo sapiens	108-118
2893390-2	1987	A previous study using in vitro techniques indicated that MIF-1 (Pro-Leu-Gly-NH2) and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), peptides with anti-opiate activity, enhanced GABA-stimulated benzodiazepine binding.	Benzodiazepines	180-194	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	58-63
2893390-2	1987	A previous study using in vitro techniques indicated that MIF-1 (Pro-Leu-Gly-NH2) and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), peptides with anti-opiate activity, enhanced GABA-stimulated benzodiazepine binding.	Benzodiazepines	180-194	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	90-95
2893390-4	1987	Tyr-MIF-1, at a dose of 1 mg/kg IP, significantly augmented benzodiazepine binding in cortex and hippocampus but not in cerebellum, hypothalamus, or pons-medulla.	Benzodiazepines	60-74	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	4-9
2889610-5	1987	The GABAA action could be enhanced by concurrent application of either benzodiazepine, midazolam or flurazepam.	Benzodiazepines	71-85	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	4-9
2825924-2	1987	Based upon this finding and literature data demonstrating a pronounced correlation between the distribution of "peripheral-type" benzodiazepine receptors and ANP receptors, it is suggested that ANP may be an allosteric regulator of the astrocytic benzodiazepine binding site.	Benzodiazepines	129-143	natriuretic peptide A	Homo sapiens	194-197
2449225-1	1987	The interaction of several phenothiazines, benzodiazepines, butyrophenones, polycyclic neuroleptics and tricyclic antidepressants with calmodulin and troponin C was investigated using the fluorescent dye 3,3"-dipropylthiocarbocyanine iodide.	Benzodiazepines	43-58	calmodulin 1	Homo sapiens	135-145
2887252-1	1987	The present study was designed to clarify the mechanism of action of benzodiazepines (BDZ) injected into the central amygdala (ACE) and mammillary body (MB).	Benzodiazepines	69-84	angiotensin I converting enzyme	Homo sapiens	127-130
3628621-4	1987	A reduction in brain 5-HT function may underlie some of the acute therapeutic actions of benzodiazepines.	Benzodiazepines	89-104	POU class 6 homeobox 1	Homo sapiens	15-22
2887252-1	1987	The present study was designed to clarify the mechanism of action of benzodiazepines (BDZ) injected into the central amygdala (ACE) and mammillary body (MB).	Benzodiazepines	86-89	angiotensin I converting enzyme	Homo sapiens	127-130
2887252-7	1987	The GABA-ergic, cholinergic, serotonergic and NA-ergic systems seem to be involved in the mechanism of anticonflict action of BDZ in ACE.	Benzodiazepines	126-129	angiotensin I converting enzyme	Homo sapiens	133-136
3033417-0	1987	The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric acid on alpha-MSH release from neurointermediate lobes in vitro.	Benzodiazepines	4-18	proopiomelanocortin	Homo sapiens	92-101
2853945-3	1987	Choline acetyltransferase activity was reduced significantly from control values at cyanide concentrations greater than 100 microM; there were similar reductions on a percentage basis in high-affinity uptake of beta-alanine and GABA and in clonazepam-displaceable benzodiazepine (BDZ) binding which reflected the neuronal BDZ receptor population.	Benzodiazepines	264-278	choline acetyltransferase	Mus musculus	0-25
2853945-3	1987	Choline acetyltransferase activity was reduced significantly from control values at cyanide concentrations greater than 100 microM; there were similar reductions on a percentage basis in high-affinity uptake of beta-alanine and GABA and in clonazepam-displaceable benzodiazepine (BDZ) binding which reflected the neuronal BDZ receptor population.	Benzodiazepines	280-283	choline acetyltransferase	Mus musculus	0-25
2821427-1	1987	Diazepam binding inhibitor (DBI) belongs to a family of newly discovered neuropeptides that, when acting on the benzodiazepine/beta-carboline recognition site, provide an allosteric modulation of the function of GABAA receptor.	Benzodiazepines	112-126	diazepam binding inhibitor	Rattus norvegicus	0-32
2821428-4	1987	The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.	Benzodiazepines	116-130	diazepam binding inhibitor	Rattus norvegicus	18-44
2821428-4	1987	The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.	Benzodiazepines	116-130	diazepam binding inhibitor	Rattus norvegicus	46-49
2821428-4	1987	The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.	Benzodiazepines	181-196	diazepam binding inhibitor	Rattus norvegicus	18-44
2821428-4	1987	The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.	Benzodiazepines	181-196	diazepam binding inhibitor	Rattus norvegicus	46-49
2439424-6	1987	If administered in anticonvulsively effective concentrations, phenobarbital and benzodiazepines enhance the GABAerg inhibition by direct attachment to the GABA receptor chloride ionophore complex of the postsynaptic neuronal membrane.	Benzodiazepines	80-95	GABA type A receptor-associated protein	Homo sapiens	155-168
3579913-2	1987	The benzodiazepines alprazolam and triazolam, but not diazepam (1-10 microM), inhibit PAF induced aggregation but have no effect on aggregation induced by other platelet agonists such as ADP, epinephrine and collagen.	Benzodiazepines	4-19	PCNA clamp associated factor	Homo sapiens	86-89
2836493-0	1987	Benzodiazepines inhibit in vitro free radical formation from human neutrophils induced by FMLP and A23187.	Benzodiazepines	0-15	formyl peptide receptor 1	Homo sapiens	90-94
3819722-1	1987	Diazepam binding inhibitor (DBI), a peptide located in CNS neurons, blocks the binding of benzodiazepines and beta-carbolines to the allosteric modulatory sites of gamma-aminobutyric acid (GABAA) receptors.	Benzodiazepines	90-105	diazepam binding inhibitor	Rattus norvegicus	0-32
3029781-3	1987	Both the content of DBI and DBI mRNA increased in the cerebellum and cerebral cortex but failed to change in the hippocampus and striatum of rats receiving this protracted benzodiazepine treatment.	Benzodiazepines	172-186	diazepam binding inhibitor	Rattus norvegicus	28-31
3029781-7	1987	It is inferred that tolerance to benzodiazepines is associated with an increase in the turnover rate of DBI, which may be responsible for the gamma-aminobutyric acid receptor desensitization that occurs after protracted benzodiazepine administration.	Benzodiazepines	33-48	diazepam binding inhibitor	Rattus norvegicus	104-107
3029781-7	1987	It is inferred that tolerance to benzodiazepines is associated with an increase in the turnover rate of DBI, which may be responsible for the gamma-aminobutyric acid receptor desensitization that occurs after protracted benzodiazepine administration.	Benzodiazepines	33-47	diazepam binding inhibitor	Rattus norvegicus	104-107
3035297-0	1987	Naloxone-sensitive and GABAA receptor mediated analgesic response of benzodiazepines in mice.	Benzodiazepines	69-84	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	23-28
3035297-6	1987	When the involvement of the GABAergic system in the analgesic response of BZ agonists was investigated, a potentiation of BZ action was seen as a combination of a subeffective dose of clonazepam with a subanalgesic dose of muscimol, a specific GABAA agonist, showed an enhanced effect.	Benzodiazepines	122-124	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	244-249
3815094-1	1987	The blood-brain transport and regional distribution of a tritium-labeled, brominated benzodiazepine (BFB) was determined for the rat brain in vivo.	Benzodiazepines	85-99	ring finger protein 112	Rattus norvegicus	101-104
2836493-3	1987	Ro 5-4864, a specific ligand for peripheral type benzodiazepine (BZ) binding site, inhibited superoxide generation induced by FMLP, while clonazepam (CNZ), which is selective for brain sites, did not possess any activity.	Benzodiazepines	65-67	formyl peptide receptor 1	Homo sapiens	126-130
3040981-1	1987	The GABA  receptor of mammalian brain is a ligand-gated channel protein with allosteric binding sites for the benzodiazepines and barbiturate drugs.	Benzodiazepines	110-125	GABA type A receptor-associated protein	Homo sapiens	4-18
20501189-0	1987	The GABA(A) receptor complex in the developing chick optic tectum: characterization of benzodiazepine and ionophore-linked convulsant/barbiturate recognition sites.	Benzodiazepines	87-101	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	4-20
20501189-1	1987	By use of membrane preparations and incubation conditions optimized for each binding site, we have characterized the benzodiazepine and ionophore-linked-convulsant/barbiturate modulatory sites within the chick tectal GABA(A) receptor complex.	Benzodiazepines	117-131	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	217-233
3502572-7	1987	Like c-fos, these TIS genes induced by NGF could also be superinduced by the combined administration of NGF and benzodiazepine.	Benzodiazepines	112-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	5-10
3502572-7	1987	Like c-fos, these TIS genes induced by NGF could also be superinduced by the combined administration of NGF and benzodiazepine.	Benzodiazepines	112-126	nerve growth factor	Rattus norvegicus	39-42
3022663-3	1986	Diazepam-binding inhibitor is present, though not exclusively, in gamma-aminobutyric acid (GABA)-containing neurons where it is believed to inhibit GABAergic neurotransmission mediated by GABA by binding to the benzodiazepine-GABA receptor complex.	Benzodiazepines	211-225	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
2883334-0	1987	Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.	Benzodiazepines	48-62	cholecystokinin	Mus musculus	28-31
2883334-0	1987	Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.	Benzodiazepines	48-62	cholecystokinin	Mus musculus	77-80
2883334-5	1987	From these results, it was considered that the antagonism, which was observed in the present work, of benzodiazepines and proglumide to CCK8 seemed to occur at the CCK receptor and not at the benzodiazepine receptor in the brain.	Benzodiazepines	102-117	cholecystokinin	Mus musculus	136-139
2431244-0	1986	Barbiturate and benzodiazepine modulation of GABA receptor binding and function.	Benzodiazepines	16-30	GABA type A receptor-associated protein	Homo sapiens	45-58
2430780-3	1986	The benzodiazepines dissociated the cochlear recorded potentials, increasing the cAP amplitude, in response to clicks, and decreasing the CM area, produced by a coherent pure tone pip.	Benzodiazepines	4-19	prolactin-inducible protein homolog	Cavia porcellus	180-183
3807051-4	1986	These results suggest that beta-CCM and beta-CCE, so-called inverse agonists of benzodiazepines (BZP), antagonize the CCK action in the gallbladder muscle in a competitive manner, and the antagonism takes place at CCK receptor sites.	Benzodiazepines	80-95	cholecystokinin	Cavia porcellus	118-121
3807051-4	1986	These results suggest that beta-CCM and beta-CCE, so-called inverse agonists of benzodiazepines (BZP), antagonize the CCK action in the gallbladder muscle in a competitive manner, and the antagonism takes place at CCK receptor sites.	Benzodiazepines	80-95	cholecystokinin	Cavia porcellus	214-217
3807051-4	1986	These results suggest that beta-CCM and beta-CCE, so-called inverse agonists of benzodiazepines (BZP), antagonize the CCK action in the gallbladder muscle in a competitive manner, and the antagonism takes place at CCK receptor sites.	Benzodiazepines	97-100	cholecystokinin	Cavia porcellus	118-121
3807051-4	1986	These results suggest that beta-CCM and beta-CCE, so-called inverse agonists of benzodiazepines (BZP), antagonize the CCK action in the gallbladder muscle in a competitive manner, and the antagonism takes place at CCK receptor sites.	Benzodiazepines	97-100	cholecystokinin	Cavia porcellus	214-217
3020548-1	1986	Diazepam binding inhibitor (DBI) is a protein that displaces ligands bound to the beta-carboline/benzodiazepine recognition site, an allosteric modulatory site of the type A gamma-aminobutyric acid receptor complex.	Benzodiazepines	97-111	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
3463960-4	1986	In addition to high levels of mRNA in various brain regions, RNA blot analysis reveals an abundance of diazepam binding inhibitor mRNA in many peripheral organs (e.g., testes, kidney, liver, and heart) that are known to be rich in peripheral benzodiazepine recognition sites.	Benzodiazepines	242-256	diazepam binding inhibitor	Rattus norvegicus	103-129
3020548-1	1986	Diazepam binding inhibitor (DBI) is a protein that displaces ligands bound to the beta-carboline/benzodiazepine recognition site, an allosteric modulatory site of the type A gamma-aminobutyric acid receptor complex.	Benzodiazepines	97-111	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	28-31
3745175-1	1986	A protein termed endozepine (EP) which inhibits the binding of benzodiazepines to synaptosomal membranes (Ki approximately 5 microM) has been purified to electrophoretic homogeneity from bovine and human brain using acidic ethanol/chloroform extraction, Bio-Sil TSK-250 gel permeation chromatography, and reverse-phase high performance liquid chromatographies.	Benzodiazepines	63-78	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	29-31
3749390-1	1986	Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers.	Benzodiazepines	62-76	growth hormone 1	Homo sapiens	85-99
3022619-8	1986	The benzodiazepines act by increasing the affinity of the GABA receptor for its ligand, thereby augmenting the inhibitory effect of a given concentration of GABA.	Benzodiazepines	4-19	GABA type A receptor-associated protein	Homo sapiens	58-71
2867816-1	1986	To investigate the mechanisms of gamma-aminobutyric acid (GABA) and benzodiazepine-induced growth hormone (GH) release, we studied the effects of GABA and a water-soluble benzodiazepine, midazolam, on basal immunoreactive somatostatin secretion from fetal rat brain in dispersed cell culture.	Benzodiazepines	68-82	gonadotropin releasing hormone receptor	Rattus norvegicus	91-105
2873849-0	1986	[Effect of benzodiazepines on the activity of AMP deaminase and adenosine deaminase in rat brain tissue in vivo].	Benzodiazepines	11-26	adenosine deaminase	Rattus norvegicus	64-83
2873044-0	1986	Effects of benzodiazepines on responses of guinea-pig ileum and gall-bladder and rat pancreatic acini to cholecystokinin.	Benzodiazepines	11-26	cholecystokinin	Rattus norvegicus	105-120
2873044-1	1986	Bradwejn and De Montigny have recently shown that benzodiazepines selectively inhibit excitation of hippocampal neurones by cholecystokinin (CCK).	Benzodiazepines	50-65	cholecystokinin	Rattus norvegicus	124-139
2873044-1	1986	Bradwejn and De Montigny have recently shown that benzodiazepines selectively inhibit excitation of hippocampal neurones by cholecystokinin (CCK).	Benzodiazepines	50-65	cholecystokinin	Rattus norvegicus	141-144
3010677-2	1986	The GABA receptor-ionophore complex also contains modulatory receptor sites for two classes of centrally acting drugs, one for the benzodiazepines, and a second for both barbiturates and related depressants and for picrotoxin and related convulsants.	Benzodiazepines	131-146	GABA type A receptor-associated protein	Homo sapiens	4-17
3010677-6	1986	We have examined the postsynaptic GABA receptor complex using receptor binding assays for GABA, benzodiazepine (BZ), and barbiturate receptor sites in the seizure-susceptible gerbil, a genetic model of generalized epilepsy.	Benzodiazepines	96-110	GABA type A receptor-associated protein	Homo sapiens	34-47
3010677-6	1986	We have examined the postsynaptic GABA receptor complex using receptor binding assays for GABA, benzodiazepine (BZ), and barbiturate receptor sites in the seizure-susceptible gerbil, a genetic model of generalized epilepsy.	Benzodiazepines	112-114	GABA type A receptor-associated protein	Homo sapiens	34-47
3010680-13	1986	The results demonstrate that phenytoin, carbamazepine, and the benzodiazepines were effective in inhibiting calcium calmodulin protein kinase activity in membrane and purified kinase preparations, vesicle neurotransmitter release, vesicle-membrane interactions, and voltage-sensitive calcium uptake in intact synaptosomes.	Benzodiazepines	63-78	calmodulin 1	Homo sapiens	116-126
3014114-7	1986	In three test procedures indicative of TRH agonist activity; thyroid-stimulating hormone release, reversal of pentobarbital sleeping time in mice and elevation of cerebellar cyclic GMP levels, the benzodiazepines were found to be devoid of activity, whereas TRH and related compounds produced their expected responses.	Benzodiazepines	197-212	thyrotropin releasing hormone	Mus musculus	39-42
3014114-7	1986	In three test procedures indicative of TRH agonist activity; thyroid-stimulating hormone release, reversal of pentobarbital sleeping time in mice and elevation of cerebellar cyclic GMP levels, the benzodiazepines were found to be devoid of activity, whereas TRH and related compounds produced their expected responses.	Benzodiazepines	197-212	5'-nucleotidase, cytosolic II	Mus musculus	181-184
3766273-10	1986	This site has certain features in common with the indole or benzodiazepine binding site of human serum albumin.	Benzodiazepines	60-74	albumin	Homo sapiens	97-110
2867816-1	1986	To investigate the mechanisms of gamma-aminobutyric acid (GABA) and benzodiazepine-induced growth hormone (GH) release, we studied the effects of GABA and a water-soluble benzodiazepine, midazolam, on basal immunoreactive somatostatin secretion from fetal rat brain in dispersed cell culture.	Benzodiazepines	68-82	gonadotropin releasing hormone receptor	Rattus norvegicus	107-109
2867816-5	1986	These results suggest that suppression of the GH inhibitory peptide, somatostatin, may be one of the mechanisms by which GABA and benzodiazepines stimulate GH secretion.	Benzodiazepines	130-145	gonadotropin releasing hormone receptor	Rattus norvegicus	46-48
2867816-5	1986	These results suggest that suppression of the GH inhibitory peptide, somatostatin, may be one of the mechanisms by which GABA and benzodiazepines stimulate GH secretion.	Benzodiazepines	130-145	gonadotropin releasing hormone receptor	Rattus norvegicus	156-158
2868969-2	1986	The interaction of the bicuculline-sensitive GABA receptor (GABA A) ionophore complex with barbiturates and benzodiazepines suggests that at least three binding sites are required to explain the independent GABA-mimetic, GABA-potentiating and picrotoxin-reversing effects of such agents.	Benzodiazepines	108-123	GABA type A receptor-associated protein	Homo sapiens	45-58
3032426-0	1986	Structure-activity relationship of peptide fragments derived from DBI (diazepam binding inhibitor), a putative endogenous ligand of benzodiazepine recognition sites.	Benzodiazepines	132-146	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	66-69
3032426-0	1986	Structure-activity relationship of peptide fragments derived from DBI (diazepam binding inhibitor), a putative endogenous ligand of benzodiazepine recognition sites.	Benzodiazepines	132-146	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	71-97
20493105-0	1986	Significance of the enhancement of GABA receptor binding with low affinity in the assessment of central effects of benzodiazepine derivatives: Analysis using a 1H-1,2,4-triazolyl benzophenone derivative (450191-S).	Benzodiazepines	115-129	GABA type A receptor-associated protein	Homo sapiens	35-48
3714803-1	1986	The binding of ethacrynic acid to human serum albumin was investigated by means of circular dichroism and equilibrium dialysis measurements, using native human serum albumin and albumin derivatives with chemical modifications impairing specifically drug binding to the indole and benzodiazepine binding site or the azapropazone-warfarin binding area, respectively.	Benzodiazepines	280-294	albumin	Homo sapiens	40-53
2868142-0	1985	Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines.	Benzodiazepines	94-109	cholecystokinin	Cavia porcellus	14-29
2869533-0	1986	Cholecystokinin antagonism by benzodiazepines in the food intake in mice.	Benzodiazepines	30-45	cholecystokinin	Mus musculus	0-15
2869533-1	1986	Three benzodiazepines, chlordiazepoxide, diazepam and flurazepam, were demonstrated to reverse the suppressed food intake in mice in response to cholecystokinin octapeptide (CCK8).	Benzodiazepines	6-21	cholecystokinin	Mus musculus	145-160
2994844-15	1985	It is concluded that stress-induced prolactin secretion is regulated by a benzodiazepine-mediated mechanism and that stress-induced renin but not prolactin secretion is mediated in part via beta-receptors.	Benzodiazepines	74-88	prolactin	Rattus norvegicus	36-45
2999338-2	1986	As previously reported, the highest levels of "peripheral-type" benzodiazepine binding sites and benzodiazepine receptors were found in the crude P1 and P2 fractions, respectively.	Benzodiazepines	64-78	perforin 1	Rattus norvegicus	146-155
3081931-0	1986	Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women.	Benzodiazepines	17-31	insulin	Homo sapiens	112-119
2864965-0	1985	[Effect of benzodiazepines on 5"-nucleotidase activity in rat brain].	Benzodiazepines	11-26	5' nucleotidase, ecto	Rattus norvegicus	30-45
2864965-1	1985	Experiments on 330 rats were made to study the influence of benzodiazepines (diazepam, dormicum and phenazepam) on 5"-nucleotidase activity in brain homogenates.	Benzodiazepines	60-75	5' nucleotidase, ecto	Rattus norvegicus	115-130
2868142-3	1985	These findings suggest that the binding of CCK to the CCK receptor can be inhibited by benzodiazepines.	Benzodiazepines	87-102	cholecystokinin	Cavia porcellus	43-46
2868142-3	1985	These findings suggest that the binding of CCK to the CCK receptor can be inhibited by benzodiazepines.	Benzodiazepines	87-102	cholecystokinin	Cavia porcellus	54-57
2868143-0	1985	Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.	Benzodiazepines	55-70	cholecystokinin	Mus musculus	36-51
4035354-0	1985	Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines.	Benzodiazepines	86-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
2868143-0	1985	Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.	Benzodiazepines	55-69	cholecystokinin	Mus musculus	36-51
2868143-1	1985	Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered intraperitoneally.	Benzodiazepines	149-164	cholecystokinin	Mus musculus	30-45
2868143-1	1985	Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered intraperitoneally.	Benzodiazepines	149-163	cholecystokinin	Mus musculus	30-45
4035354-0	1985	Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines.	Benzodiazepines	86-101	nerve growth factor	Rattus norvegicus	27-46
2863335-3	1985	The efficacies of modulation differ for "classical" benzodiazepines and novel nonbenzodiazepine drugs in a manner consistent with a model of control of GABA receptor action through a common receptor.	Benzodiazepines	52-67	GABA type A receptor-associated protein	Homo sapiens	152-165
3892688-3	1985	Previous studies have shown that DBI injected intraventricularly in rodents elicits "proconflict" responses and antagonizes the "anticonflict" action of benzodiazepines.	Benzodiazepines	153-168	diazepam binding inhibitor	Rattus norvegicus	33-36
2991912-0	1985	Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neurite outgrowth in PC12 cells.	Benzodiazepines	16-31	ornithine decarboxylase 1	Rattus norvegicus	42-65
2991912-1	1985	A number of the benzodiazepines (BZDs) inhibit nerve growth factor (NGF)-induced neurite outgrowth in a dose-dependent manner in PC12 cell cultures.	Benzodiazepines	16-31	nerve growth factor	Rattus norvegicus	68-71
2991912-1	1985	A number of the benzodiazepines (BZDs) inhibit nerve growth factor (NGF)-induced neurite outgrowth in a dose-dependent manner in PC12 cell cultures.	Benzodiazepines	33-37	nerve growth factor	Rattus norvegicus	68-71
2991912-7	1985	The OrnDCase response to BZDs is blocked by actinomycin D.	Benzodiazepines	25-29	ornithine decarboxylase 1	Rattus norvegicus	4-12
2991912-8	1985	Furthermore, the structural requirements of BZDs for induction of OrnDCase activity is not identical to that for the inhibition of NGF-induced neurite extension.	Benzodiazepines	44-48	ornithine decarboxylase 1	Rattus norvegicus	66-74
2991912-9	1985	Thus, unlike attenuation of neurite extension, BZD induction of OrnDCase is not stereospecific.	Benzodiazepines	47-50	ornithine decarboxylase 1	Rattus norvegicus	64-72
2987411-7	1985	These results suggest a close association between reversible and irreversible benzodiazepine binding sites and indicate that membrane-associated proteins P51 and P55 are differentially protected against degradation by trypsin.	Benzodiazepines	78-92	MAGUK p55 scaffold protein 1	Rattus norvegicus	162-165
2857784-0	1985	Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells.	Benzodiazepines	0-15	phospholipase A2 group IB	Homo sapiens	61-77
2859216-0	1985	Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea-pig gallbladder.	Benzodiazepines	30-45	cholecystokinin	Cavia porcellus	0-15
2859216-1	1985	Three benzodiazepines, chlordiazepoxide (CDP), diazepam (DZP) and medazepam (MZP), inhibited the contractile response of circular muscle strips from the isolated guinea-pig gallbladder to sulfated cholecystokinin octapeptide (CCK8) in the presence of atropine.	Benzodiazepines	6-21	cholecystokinin	Cavia porcellus	197-212
6095093-0	1984	Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurones.	Benzodiazepines	0-15	cholecystokinin	Rattus norvegicus	27-42
2983718-2	1985	In the presence of the benzodiazepine tranquillizer, chlordiazepoxide, the TRH concentration-response curves for these effects were shifted to the right in a parallel fashion.	Benzodiazepines	23-37	thyrotropin releasing hormone	Rattus norvegicus	75-78
2859382-0	1985	Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.	Benzodiazepines	57-72	cholecystokinin	Mus musculus	38-53
2859382-0	1985	Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.	Benzodiazepines	57-71	cholecystokinin	Mus musculus	38-53
2859382-5	1985	Benzodiazepines and Ro 15-1788 seem to inhibit the release of opioid peptides induced by cholecystokinin.	Benzodiazepines	0-15	cholecystokinin	Mus musculus	89-104
3001768-3	1985	In this test DBI acts like an anxiogenic endocoid for the benzodiazepine recognition sites.	Benzodiazepines	58-72	diazepam binding inhibitor	Rattus norvegicus	13-16
6146660-0	1984	Modulation of receptors for thyrotropin-releasing hormone by benzodiazepines: brain regional differences.	Benzodiazepines	61-76	thyrotropin releasing hormone	Homo sapiens	28-57
6098849-0	1984	A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites.	Benzodiazepines	133-147	diazepam binding inhibitor	Rattus norvegicus	63-66
6098849-0	1984	A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites.	Benzodiazepines	133-147	diazepam binding inhibitor	Rattus norvegicus	68-94
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Benzodiazepines	21-25	thyrotropin releasing hormone	Homo sapiens	150-153
6090223-6	1984	The complex of GABA receptor and chloride ion channel contains modulatory sites for barbiturates and benzodiazepines, drugs that enhance GABA responses in neurons.	Benzodiazepines	101-116	GABA type A receptor-associated protein	Homo sapiens	15-28
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Benzodiazepines	4-19	thyrotropin releasing hormone	Homo sapiens	119-148
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Benzodiazepines	4-19	thyrotropin releasing hormone	Homo sapiens	150-153
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Benzodiazepines	21-25	thyrotropin releasing hormone	Homo sapiens	119-148
6147122-0	1984	Interactions of cholinesterase inhibitors and corticosteroids with the hypnotic effect of benzodiazepines in mice.	Benzodiazepines	90-105	butyrylcholinesterase	Mus musculus	16-30
6089051-1	1984	Diazepam binding inhibitor (DBI), a brain neuropeptide putative ligand for benzodiazepine binding sites, has been isolated and purified to homogeneity.	Benzodiazepines	75-89	diazepam binding inhibitor	Rattus norvegicus	0-26
6089051-1	1984	Diazepam binding inhibitor (DBI), a brain neuropeptide putative ligand for benzodiazepine binding sites, has been isolated and purified to homogeneity.	Benzodiazepines	75-89	diazepam binding inhibitor	Rattus norvegicus	28-31
6089051-9	1984	The latter might be the natural effector of benzodiazepine recognition sites while DBI could be a polyprotein functioning as the precursor of the putative endogenous ligand of the benzodiazepine recognition site.	Benzodiazepines	180-194	diazepam binding inhibitor	Rattus norvegicus	83-86
6147122-1	1984	Interactions of cholinesterase inhibitors or dexamethasone with the hypnotic effect of benzodiazepines appear to be strongly dependent on the dose of the cholinesterase inhibitor used and to a lesser extent on the dose of the hypnotic.	Benzodiazepines	87-102	butyrylcholinesterase	Mus musculus	16-30
6147122-1	1984	Interactions of cholinesterase inhibitors or dexamethasone with the hypnotic effect of benzodiazepines appear to be strongly dependent on the dose of the cholinesterase inhibitor used and to a lesser extent on the dose of the hypnotic.	Benzodiazepines	87-102	butyrylcholinesterase	Mus musculus	154-168
6429801-5	1984	In fact, the presence of halogens at C-2, a methyl group at N-1 and a methylene substituent instead of a keto group at C-3 in the benzodiazepine structure increased the inhibitory effect.	Benzodiazepines	130-144	complement C2	Rattus norvegicus	37-40
6429801-5	1984	In fact, the presence of halogens at C-2, a methyl group at N-1 and a methylene substituent instead of a keto group at C-3 in the benzodiazepine structure increased the inhibitory effect.	Benzodiazepines	130-144	complement C3	Rattus norvegicus	119-122
6150680-5	1984	Phenytoin, carbamazepine, and the benzodiazepines inhibit Ca2+ -calmodulin-regulated protein phosphorylation and neurotransmitter release by synaptic vesicles.	Benzodiazepines	34-49	calmodulin 2	Mus musculus	64-74
6712779-3	1984	The studies presented here indicate that diazepam, the most widely used benzodiazepine, is an inhibitor of cholesterol esterification by ACAT in vitro in atheromatous rabbit aortas, in microsomes isolated from atheromatous rabbit aortas, and in normal rat aortas.	Benzodiazepines	72-86	sterol O-acyltransferase 1	Oryctolagus cuniculus	137-141
6325210-3	1984	Both Trp-P-1 and Trp-P-2 inhibited the specific binding of [3H]diazepam and [3H]muscimol in rat brain membranes mainly by increasing Kd, indicating that these gamma-carbolines bind on benzodiazepine and GABA receptors.	Benzodiazepines	184-198	polycystin 2, transient receptor potential cation channel	Rattus norvegicus	17-24
6319679-0	1984	Benzodiazepines: rat pinealocyte binding sites and augmentation of norepinephrine-stimulated N-acetyltransferase activity.	Benzodiazepines	0-15	N-acetyltransferase 1	Rattus norvegicus	93-112
6319679-9	1984	Although a relationship between the [3H]diazepam binding sites described here and the effect of benzodiazepines on NAT cannot be established from these studies, the data suggest that the benzodiazepines may alter melatonin levels through their action on NAT.	Benzodiazepines	96-111	N-acetyltransferase 1	Rattus norvegicus	115-118
6319679-9	1984	Although a relationship between the [3H]diazepam binding sites described here and the effect of benzodiazepines on NAT cannot be established from these studies, the data suggest that the benzodiazepines may alter melatonin levels through their action on NAT.	Benzodiazepines	187-202	N-acetyltransferase 1	Rattus norvegicus	254-257
6320963-1	1984	Benzodiazepines reduce basal and stimulated rat prolactin (PRL) serum levels in vivo.	Benzodiazepines	0-15	prolactin	Rattus norvegicus	59-62
6426979-2	1984	It was found that some, but not all, benzodiazepines displaced [3H]( 3MeHis2 )TRH from its binding site.	Benzodiazepines	37-52	thyrotropin releasing hormone	Homo sapiens	78-81
6150684-2	1984	In particular, two classes of anticonvulsant agents, the benzodiazepines and the barbiturates, have modulatory receptor sites on the GABA receptor-ionophore protein complex of the postsynaptic membrane.	Benzodiazepines	57-72	GABA type A receptor-associated protein	Homo sapiens	133-146
6322040-10	1983	Since most of the GABA agonists do not pass the blood-brain barrier, future trends in the pharmacology of GABA may be the development of drugs that will activate the GABA receptor system via picrotoxinin or benzodiazepine sites.	Benzodiazepines	207-221	GABA type A receptor-associated protein	Homo sapiens	166-179
6145182-6	1984	Comparison of follicular plasma samples during the placebo phase and fourth month of benzodiazepine found a significant increase in sex hormone binding globulin and a significant decrease in dehydroepiandrosterone sulphate with benzodiazepine therapy.	Benzodiazepines	85-99	sex hormone binding globulin	Homo sapiens	132-160
6322044-11	1983	However, the potency of analogues for inhibition of the release of prolactin and TSH following systemic administration indicates that benzodiazepines with affinity for the central subtype of receptors were the most potent.	Benzodiazepines	134-149	prolactin	Rattus norvegicus	67-76
6640316-5	1983	Methyl-beta-carboline-3-carboxylate seems to have effects on the firing of CA1 neurons which are similar to the effects reported for ethyl-beta-carboline-3-carboxylate and opposite to those reported for the benzodiazepines midazolam and diazepam.	Benzodiazepines	207-222	carbonic anhydrase 1	Rattus norvegicus	75-78
6320064-0	1983	Benzodiazepines compete for thyrotropin-releasing hormone receptor binding: micromolar potency in rat pituitary, retina and amygdala.	Benzodiazepines	0-15	thyrotropin releasing hormone receptor	Rattus norvegicus	28-66
6320064-1	1983	In screening neuroactive compounds for their possible interaction with rat thyrotropin-releasing hormone (TRH) receptors, some benzodiazepines were found to compete relatively potently for specific [3H](3-Me-His2)TRH [( 3H]MeTRH) binding.	Benzodiazepines	127-142	thyrotropin releasing hormone	Rattus norvegicus	106-109
6131706-0	1983	[Changes in the GABA-transaminase activity in various structures of the rat brain after administration of benzodiazepine tranquilizers].	Benzodiazepines	106-120	4-aminobutyrate aminotransferase	Rattus norvegicus	16-33
6320064-1	1983	In screening neuroactive compounds for their possible interaction with rat thyrotropin-releasing hormone (TRH) receptors, some benzodiazepines were found to compete relatively potently for specific [3H](3-Me-His2)TRH [( 3H]MeTRH) binding.	Benzodiazepines	127-142	thyrotropin releasing hormone	Rattus norvegicus	213-216
6320064-6	1983	These data support previous evidence for a close similarity of TRH receptors in the pituitary gland and central nervous system, and invoke the possibility of TRH receptor-mediated effects for some benzodiazepines.	Benzodiazepines	197-212	thyrotropin releasing hormone	Rattus norvegicus	158-161
6138009-8	1983	It may be that buspirone and benzodiazepine drugs stimulate GH secretion by a common mechanism that is related to their anxiolytic actions.	Benzodiazepines	29-43	growth hormone 1	Homo sapiens	60-62
6138010-0	1983	Long-term benzodiazepine administration blunts growth hormone response to diazepam.	Benzodiazepines	10-24	growth hormone 1	Homo sapiens	47-61
6138010-2	1983	The growth hormone response was significantly attenuated during benzodiazepine administration, but increased significantly after benzodiazepine treatment was discontinued.	Benzodiazepines	64-78	growth hormone 1	Homo sapiens	4-18
6138010-2	1983	The growth hormone response was significantly attenuated during benzodiazepine administration, but increased significantly after benzodiazepine treatment was discontinued.	Benzodiazepines	129-143	growth hormone 1	Homo sapiens	4-18
6311332-0	1983	Low-dose benzodiazepine neuronal inhibition: enhanced Ca2+-mediated K+-conductance.	Benzodiazepines	9-23	carbonic anhydrase 2	Homo sapiens	54-57
6311332-1	1983	The water-soluble inhibitory benzodiazepine, midazolam, was applied in low nanomolar concentrations to CA1 hippocampal neurons in vitro, recorded intracellularly.	Benzodiazepines	29-43	carbonic anhydrase 1	Homo sapiens	103-106
6841564-0	1983	Effect of the benzodiazepine derivative, diazepam, on the clonidine-stimulated human growth hormone secretion.	Benzodiazepines	14-28	growth hormone 1	Homo sapiens	85-99
6138271-1	1983	Low intravenous doses of two benzodiazepines, lorazepam and diazepam, antagonized the activation of dorsal hippocampus CA1 pyramidal neurons by kainate to a greater extent than the activations produced by glutamate and acetylcholine.	Benzodiazepines	29-44	carbonic anhydrase 1	Rattus norvegicus	119-122
6304714-1	1983	A brain polypeptide termed diazepam-binding inhibitor (DBI) and thought to be chemically and functionally related to the endogenous effector of the benzodiazepine recognition site was purified to homogeneity.	Benzodiazepines	148-162	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	27-53
6304714-1	1983	A brain polypeptide termed diazepam-binding inhibitor (DBI) and thought to be chemically and functionally related to the endogenous effector of the benzodiazepine recognition site was purified to homogeneity.	Benzodiazepines	148-162	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	55-58
6133770-0	1983	Interaction of histamine H2-receptor antagonists with GABA and benzodiazepine binding sites in the CNS.	Benzodiazepines	63-77	histamine receptor H 2	Rattus norvegicus	15-36
6136317-1	1983	In vivo binding of a benzodiazepine (flunitrazepam-C11) and a benzodiazepine antagonist (Ro 15-1788-C11) were studied with positron emission tomography.	Benzodiazepines	21-35	RNA polymerase III subunit K	Homo sapiens	51-54
6131706-3	1983	The degree of GABA-transaminase inhibition corresponded with pharmacological activity of the test benzodiazepines.	Benzodiazepines	98-113	4-aminobutyrate aminotransferase	Rattus norvegicus	14-31
6131706-4	1983	It is assumed that inhibition of brain GABA-transaminase by benzodiazepines is linked with their interaction with GABA-benzodiazepine receptor complex.	Benzodiazepines	60-75	4-aminobutyrate aminotransferase	Rattus norvegicus	39-56
6144509-1	1983	Benzodiazepines (BDZ) interact with specific receptors (R), whose activation improves Cl- -channel gating by the GABA receptor (GABA-R).	Benzodiazepines	0-15	GABA type A receptor-associated protein	Homo sapiens	113-126
6135742-5	1983	These examples are: 1. the modulation of the function of nicotinic receptors of chromaffin cells by endogenous opiate peptides stored in the splanchnic nerve and 2. the modulation of GABA receptor function by benzodiazepines.	Benzodiazepines	209-224	GABA type A receptor-associated protein	Homo sapiens	183-196
6886014-1	1983	Antibodies specific for benzodiazepines were raised in rabbits by immunization with a conjugate of a benzodiazepine derivative, Ro 7-1986/1, with bovine serum albumin.	Benzodiazepines	24-39	albumin	Oryctolagus cuniculus	153-166
6886014-1	1983	Antibodies specific for benzodiazepines were raised in rabbits by immunization with a conjugate of a benzodiazepine derivative, Ro 7-1986/1, with bovine serum albumin.	Benzodiazepines	24-38	albumin	Oryctolagus cuniculus	153-166
6144509-1	1983	Benzodiazepines (BDZ) interact with specific receptors (R), whose activation improves Cl- -channel gating by the GABA receptor (GABA-R).	Benzodiazepines	0-15	GABA type A receptor-associated protein	Homo sapiens	128-134
6144509-1	1983	Benzodiazepines (BDZ) interact with specific receptors (R), whose activation improves Cl- -channel gating by the GABA receptor (GABA-R).	Benzodiazepines	17-20	GABA type A receptor-associated protein	Homo sapiens	113-126
6144509-1	1983	Benzodiazepines (BDZ) interact with specific receptors (R), whose activation improves Cl- -channel gating by the GABA receptor (GABA-R).	Benzodiazepines	17-20	GABA type A receptor-associated protein	Homo sapiens	128-134
6138771-11	1983	These results indicate that ethanol, like pentobarbital, may modulate the benzodiazepine binding component of the benzodiazepine-GABA receptor-ionophore complex via the picrotoxinin site.	Benzodiazepines	74-88	GABA type A receptor-associated protein	Homo sapiens	129-142
6141552-1	1983	Temazepam, a benzodiazepine ataractic, given in a dose of 10 mg/kg ip to rats depressed the striatal contents of met-enkephalin and leu-enkephalin by 60 and 35% resp.	Benzodiazepines	13-27	proenkephalin	Rattus norvegicus	117-127
7043087-0	1982	Evaluation of the EMIT Tox enzyme immunoassay for toxicological analysis of benzodiazepines in serum.	Benzodiazepines	76-91	thymocyte selection associated high mobility group box	Homo sapiens	23-26
6129770-7	1982	Among a wide range of other CNS active compounds tested, CAR was inhibited by alpha 1-adrenergic antagonists, benzodiazepines, a barbiturate, GABA agonists, morphine and a serotonin agonist, but in doses inducing other motor disturbances.	Benzodiazepines	110-125	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	57-60
6286318-0	1982	Cerebellar cyclic GMP and behavioral effects after acute and repeated administration of benzodiazepines in mice.	Benzodiazepines	88-103	5'-nucleotidase, cytosolic II	Mus musculus	18-21
6286318-1	1982	The previous finding that benzodiazepine-induced changes in cyclic GMP in the cerebellum were poorly correlated with the impairment of motor function has now been extended further.	Benzodiazepines	26-40	5'-nucleotidase, cytosolic II	Mus musculus	67-70
6214305-4	1982	They act on the metabolism or synaptic release of GABA, or its reuptake into neurones of glia, or on various components of the GABA receptor complex (GABA recognition site, "benzodiazepine" receptor or chloride ionophore).	Benzodiazepines	174-188	GABA type A receptor-associated protein	Homo sapiens	127-140
7043087-1	1982	Immunoenzymatic test, EMIT Tox, proposed for qualitative and semi quantitative determination of toxicological levels of benzodiazepines in serum is compared with gas chromatography.	Benzodiazepines	120-135	thymocyte selection associated high mobility group box	Homo sapiens	27-30
7043087-3	1982	In semi quantitative determinations, the EMIT Tox test was applied to 139 sera with one or more of the three benzodiazepines (oxazepam, desmethyldiazepam, diazepam), showing a significant correlation with levels measured by gas chromatography; but the EMIT Tox test frequently yields values too low for elevated oxazepam and desmethyldiazepam concentrations.	Benzodiazepines	109-124	thymocyte selection associated high mobility group box	Homo sapiens	46-49
6287328-0	1982	Benzodiazepine antagonist Ro 15-1788 counteracts the prolactin-lowering effects of other benzodiazepines in rats.	Benzodiazepines	0-14	prolactin	Rattus norvegicus	53-62
6287328-1	1982	A number of centrally active benzodiazepines lowered baseline serum prolactin concentrations after oral administration to male rats.	Benzodiazepines	29-44	prolactin	Rattus norvegicus	68-77
6287328-2	1982	The increase of circulating prolactin levels elicited by oral administration of various neuroleptic agents was also reduced by prior or simultaneous oral administration of several benzodiazepines in a dose-dependent manner.	Benzodiazepines	180-195	prolactin	Rattus norvegicus	28-37
6979001-0	1982	Suppression of prolactin secretion by benzodiazepines in vivo.	Benzodiazepines	38-53	prolactin	Rattus norvegicus	15-24
6979001-1	1982	Administration of benzodiazepines to male or female rats was observed to inhibit prolactin release.	Benzodiazepines	18-33	prolactin	Rattus norvegicus	81-90
6287328-3	1982	Since both effects were prevented by simultaneous administration of the benzodiazepine antagonist Ro 15-1788 they are probably mediated by central benzodiazepine receptors which interfere with aminergic mechanisms governing serum prolactin.	Benzodiazepines	72-86	prolactin	Rattus norvegicus	230-239
6979001-2	1982	Basal secretion of prolactin was only slightly suppressed with the highest dose of benzodiazepines; however, the rise in prolactin release following a stimulus was prevented even at low doses (0.1-1 mg/kg).	Benzodiazepines	83-98	prolactin	Rattus norvegicus	19-28
6270544-6	1981	Of particular interest are the effects of GABA agonists on the binding of diazepam to the benzodiazepine binding site, assumed to be a structural unit of the GABA receptor complex.	Benzodiazepines	90-104	GABA type A receptor-associated protein	Homo sapiens	158-171
6979001-3	1982	The benzodiazepine diazepam blocked stress-induced prolactin release and, when given during the critical period of proestrus, the proestrus surge of prolactin.	Benzodiazepines	4-18	prolactin	Rattus norvegicus	51-60
6979001-3	1982	The benzodiazepine diazepam blocked stress-induced prolactin release and, when given during the critical period of proestrus, the proestrus surge of prolactin.	Benzodiazepines	4-18	prolactin	Rattus norvegicus	149-158
6979001-5	1982	Inhibition of prolactin release by benzodiazepine was dose related, and inhibition was still evident after repeated diazepam injection.	Benzodiazepines	35-49	prolactin	Rattus norvegicus	14-23
6979001-6	1982	The potency of three benzodiazepine analogues to inhibit prolactin release correlated with their potency to displace radiolabeled diazepam binding from brain membrane fractions or to induce other biological responses (clonazepam greater than diazepam greater than chlordiazepoxide).	Benzodiazepines	21-35	prolactin	Rattus norvegicus	57-66
6979001-7	1982	These actions of benzodiazepines on prolactin release are similar to those reported for gamma-aminobutyric acid (GABA).	Benzodiazepines	17-32	prolactin	Rattus norvegicus	36-45
6273709-8	1981	In this GABA receptor-ionophore system, other drug receptor sites, one for benzodiazepines and one for barbiturates/picrotoxinin (and related agents) appear to form a multicomponent complex.	Benzodiazepines	75-90	GABA type A receptor-associated protein	Homo sapiens	8-21
6110546-0	1980	Benzodiazepines modify the agonist responses at a presynaptic GABA receptor.	Benzodiazepines	0-15	GABA type A receptor-associated protein	Homo sapiens	62-75
6108979-0	1981	In vitro antagonism of benzodiazepine binding to cerebral receptors by H1 and H2 antihistamines.	Benzodiazepines	23-37	H1.5 linker histone, cluster member	Homo sapiens	71-80
6261143-4	1981	Theoretically, benzodiazepines could mimic the effect of hypothetical endogenous ligands for the benzodiazepine receptors, although there is no convincing evidence for their existence; in vitro studies indicate that benzodiazepines might compete with a modulatory peptide which is present in the supramolecular assembly formed by GABA receptor, chloride ionophore and benzodiazepine receptor and which reduces the affinity of the GABA receptor for its physiological ligand.	Benzodiazepines	15-30	GABA type A receptor-associated protein	Homo sapiens	330-343
6261143-4	1981	Theoretically, benzodiazepines could mimic the effect of hypothetical endogenous ligands for the benzodiazepine receptors, although there is no convincing evidence for their existence; in vitro studies indicate that benzodiazepines might compete with a modulatory peptide which is present in the supramolecular assembly formed by GABA receptor, chloride ionophore and benzodiazepine receptor and which reduces the affinity of the GABA receptor for its physiological ligand.	Benzodiazepines	15-30	GABA type A receptor-associated protein	Homo sapiens	430-443
6110546-2	1980	The agonist responses of this GABA receptor were modified stereoselectively by benzodiazepines at low concentrations.	Benzodiazepines	79-94	GABA type A receptor-associated protein	Homo sapiens	30-43
6110546-3	1980	The results correlate well with effects seen in [3H]GABA binding experiments and as they demonstrate benzodiazepine-induced changes in GABA receptor properties in a tissue prism preparation, these results suggest that the mechanisms described for extensively disrupted preparations may also apply to whole tissue.	Benzodiazepines	101-115	GABA type A receptor-associated protein	Homo sapiens	135-148
6252064-6	1980	Results of experiments with a convulsant benzodiazepine compound, which causes a specific reduction in GABA-mediated inhibition, are also presented, The data are discussed in terms of a model in which the benzodiazepine receptor, the GABA receptor, and the chloride ionophore are functionally linked.	Benzodiazepines	41-55	GABA type A receptor-associated protein	Homo sapiens	234-247
6106141-0	1980	Benzodiazepines modify synaptic depression, frequency facilitation and PTP an identified cholinergic synapse of Aplysia.	Benzodiazepines	0-15	protein tyrosine phosphatase receptor type U	Homo sapiens	71-74
6773525-0	1980	Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action.	Benzodiazepines	11-26	aldo-keto reductase family 1 member A1	Homo sapiens	54-72
6110313-9	1980	Benzodiazepines should be administered with caution during ECT, as they can impair the efficacy of treatments and consequently prolong the treatment period.	Benzodiazepines	0-15	ECT	Homo sapiens	59-62
29327-0	1978	Effect of benzodiazepine derivatives on human blood cholinesterase in vitro.	Benzodiazepines	10-24	butyrylcholinesterase	Homo sapiens	52-66
6103733-0	1980	Neurotransmitter receptor localizations: brain lesion induced alterations in benzodiazepine, GABA, beta-adrenergic and histamine H1-receptor binding.	Benzodiazepines	77-91	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	0-25
522892-7	1979	Whereas an increase in enkephalin concentrations in the hypothalamus may be discussed in terms of the anti-stress effect of benzodiazepines, the observed drop in striatal enkephalin is not obviously to be correlated to behavioural changes induced by these drugs.	Benzodiazepines	124-139	proenkephalin	Rattus norvegicus	23-33
38360-9	1979	By binding to their receptor, benzodiazepines appear to enhance the sensitivity of the GABA receptor, thus indirectly potentiating GABA-ergic neurotransmission in the brain.	Benzodiazepines	30-45	GABA type A receptor-associated protein	Homo sapiens	87-100
36951-0	1979	A functional antagonisms between benzodiazepines and ACTH? [proceedings].	Benzodiazepines	33-48	proopiomelanocortin	Homo sapiens	53-58
420938-0	1979	[Quantitative histochemical study of the effect of benzodiazepine tranquilizers on cerebral GABA-transaminase activity].	Benzodiazepines	51-65	4-aminobutyrate aminotransferase	Rattus norvegicus	92-109
33105065-2	2021	In this context, endozepines, endogenous analogs of benzodiazepine derived from diazepam-binding inhibitor, are now emerging as major players.	Benzodiazepines	52-66	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	80-106
22876-0	1977	[Effects of benzodiazepine derivatives on cholinesterase activity of rat blood].	Benzodiazepines	12-26	butyrylcholinesterase	Rattus norvegicus	42-56
12387-2	1976	Benzodiazepines affected the various neuronal connections of the intra-limbic, limbic-hypothalamic and midbrain-limbic systems; especially the amygdala (AMYG)-, ventromedial hypothalamus (VMH)- and central gray matter (SGC)-hippocampal (HIPP) evoked potentials were attenuated, whereas the AMYG-VMH, VMH-AMYG and the septum (SP)-VMH evoked potentials were facilitated.	Benzodiazepines	0-15	sarcoglycan beta	Homo sapiens	219-222
735610-0	1978	[Effect of benzodiazepines on the fluorescence of tryptophan in human serum albumin, hemoglobin and erythrocyte ghosts].	Benzodiazepines	11-26	albumin	Homo sapiens	70-83
863908-5	1977	The binding properties of the HSA derivatives have been tested with bilirubin, diazepam (a benzodiazepine drug), phenylbutazone, and indomethacin by circular dichroism.	Benzodiazepines	91-105	albumin	Homo sapiens	30-33
13240-7	1977	It was shown that benzodiazepines decrease the amount of L-tryptophan bound to serum albumin in vitro and in vivo and increased therewith the L-tryptophan concentration in the brain.	Benzodiazepines	18-33	albumin	Homo sapiens	85-92
34052299-3	2021	This study was designed to investigate if the differential expression of GABAA receptor subunits alpha1/alpha4/gamma2/delta across the postsynaptic sites could contribute to benzodiazepine resistance in patients with focal cortical dysplasia (FCD), the most common cause of drug resistant epilepsy in pediatric population.	Benzodiazepines	174-188	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	73-123
34014994-9	2021	Our data suggest that benzodiazepines influence T cell proliferation through both TSPO and GABA(A)Rs activation.	Benzodiazepines	22-37	translocator protein	Homo sapiens	82-86
34004209-9	2021	These findings suggest that diazepam induces the anxiety-like behavior under inflammation conditions, and may cause the GABAA receptor dysfunction associated with the chloride plasticity mediated by NKCC1, which contributes to benzodiazepine-induced delirium after surgery.	Benzodiazepines	227-241	solute carrier family 12, member 2	Mus musculus	199-204
33982976-0	2021	Is the Preoperative Use of Antidepressants and Benzodiazepines Associated with Opioid and Other Analgesic Use after Hip and Knee Arthroplasty?	Benzodiazepines	47-62	hedgehog interacting protein	Homo sapiens	116-119
33560206-11	2021	When accounting for the same factors, sedative benzodiazepines were associated with suicide attempts (OR 1.76 [1.06-2.87]), but not suicidal ideation (OR 1.37 [0.99-1.88]) or suicide planning (OR 1.39 [0.97-2.00]).	Benzodiazepines	47-62	olfactory receptor family 1 subfamily A member 2	Homo sapiens	102-109
33560206-11	2021	When accounting for the same factors, sedative benzodiazepines were associated with suicide attempts (OR 1.76 [1.06-2.87]), but not suicidal ideation (OR 1.37 [0.99-1.88]) or suicide planning (OR 1.39 [0.97-2.00]).	Benzodiazepines	47-62	olfactory receptor family 14 subfamily K member 1	Homo sapiens	193-200
33081562-7	2021	The benzodiazepines diazepam, midazolam and 7-aminoflunitrazepan were detected in 46% of the positive samples (0.02-1.12 microg/mL; midazolam only qualitative).	Benzodiazepines	4-19	thrombopoietin	Mus musculus	128-130
33872962-6	2021	We demonstrated that the use of benzodiazepines (HR = 1.87 [1.25; 2.81], p < 0.01) and hypnotics (HR = 1.49 [1.03; 2.17], p = 0.04) or a combination of both (HR = 1.80 [1.17; 2.72], p = 0.01) were associated with suicide reattempt within 14 months after a previous SA.	Benzodiazepines	32-47	acyl-CoA synthetase medium chain family member 3	Homo sapiens	265-267
33924822-1	2021	We sought to evaluate the success rate of a benzodiazepine-sparing analgosedation protocol (ASP) in mechanically ventilated children and determine the effect of compliance with ASP on in-hospital outcome measures.	Benzodiazepines	44-58	assembly factor for spindle microtubules	Homo sapiens	92-95
33924822-6	2021	Children sedated with the ASP had decrease in opiate withdrawal (OR 0.16, 0.08-0.32), decreased duration of mechanical ventilation (adjusted mean duration 1.81 vs. 3.39 days, p = 0.018), and decreased PICU length of stay (adjusted mean 3.15 vs. 4.7 days, p = 0.011), when compared to the cohort of children who received continuous benzodiazepine infusions.	Benzodiazepines	331-345	assembly factor for spindle microtubules	Homo sapiens	26-29
33921765-1	2021	INTRODUCTION: Benzodiazepines, including temazepam are described as TSPO antagonists.	Benzodiazepines	14-29	translocator protein	Homo sapiens	68-72
34043402-9	2021	In a participant with severe, treatment refractory opioid and benzodiazepine use disorder, DBS of the NAc/VC was safe, reduced substance use and craving, and improved frontal and executive functions.	Benzodiazepines	62-76	synuclein alpha	Homo sapiens	102-105
33769215-1	2021	Expression of the 18-kDa translocator protein (TSPO), originally identified as a peripheral benzodiazepine receptor, has been found to be altered in several psychiatric disorders.	Benzodiazepines	92-106	translocator protein	Homo sapiens	47-51
32830517-1	2021	BACKGROUND: Benzodiazepine is first-line therapy for alcohol withdrawal syndrome (AWS), and phenobarbital is an alternative therapy.	Benzodiazepines	12-26	jagged canonical Notch ligand 1	Homo sapiens	82-85
33769215-1	2021	Expression of the 18-kDa translocator protein (TSPO), originally identified as a peripheral benzodiazepine receptor, has been found to be altered in several psychiatric disorders.	Benzodiazepines	92-106	translocator protein	Homo sapiens	25-45
33643818-1	2021	The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in steroidogenic cells.	Benzodiazepines	75-89	translocator protein	Homo sapiens	33-37
33554986-4	2021	GABAA receptors are targets for numerous drugs, including benzodiazepines, which bind to alpha1beta2gamma2 GABAA receptors with high affinity to a site in the extracellular domain, between subunits alpha1 and gamma2.	Benzodiazepines	58-73	BCL2 related protein A1	Homo sapiens	89-95
33554986-4	2021	GABAA receptors are targets for numerous drugs, including benzodiazepines, which bind to alpha1beta2gamma2 GABAA receptors with high affinity to a site in the extracellular domain, between subunits alpha1 and gamma2.	Benzodiazepines	58-73	tryptophanyl-tRNA synthetase 1	Homo sapiens	100-106
33338971-2	2021	Less is known about ligands that modulate the peripheral benzodiazepine receptor - meanwhile known as the translocator protein 18 kDa (TSPO) - which constitute promising candidates in the search of novel anxiolytics.	Benzodiazepines	57-71	translocator protein	Homo sapiens	106-133
30504824-2	2021	Here, we find that systemic BZDs modulate central amygdala (CEA) microcircuit activity to gate amygdala output.	Benzodiazepines	28-32	CEA cell adhesion molecule 6	Homo sapiens	60-63
30504824-6	2021	We propose that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST+/PKCdelta- neurons and reshaping intra-CEA circuit dynamics.	Benzodiazepines	16-20	CEA cell adhesion molecule 6	Homo sapiens	69-72
30504824-6	2021	We propose that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST+/PKCdelta- neurons and reshaping intra-CEA circuit dynamics.	Benzodiazepines	16-20	CEA cell adhesion molecule 6	Homo sapiens	102-106
30504824-6	2021	We propose that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST+/PKCdelta- neurons and reshaping intra-CEA circuit dynamics.	Benzodiazepines	16-20	protein kinase C delta	Homo sapiens	112-120
30504824-6	2021	We propose that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST+/PKCdelta- neurons and reshaping intra-CEA circuit dynamics.	Benzodiazepines	16-20	CEA cell adhesion molecule 6	Homo sapiens	102-105
33338971-2	2021	Less is known about ligands that modulate the peripheral benzodiazepine receptor - meanwhile known as the translocator protein 18 kDa (TSPO) - which constitute promising candidates in the search of novel anxiolytics.	Benzodiazepines	57-71	translocator protein	Homo sapiens	135-139
32386503-4	2021	RESULTS: The results demonstrated that the neuropharmacological activities of beta-CBP may involve benzodiazepine/GABAergic receptors, since the pre-treatment of beta-CBP (200 mg/kg) associated with flumazenil (5 mg/kg, benzodiazepine receptor antagonist) and bicuculline (1 mg/kg, selective GABAA receptor antagonist) reestablished the anxiety parameters in the elevated plus-maze test, as well as the results of reduced latency to consume food in the novelty suppressed feeding test.	Benzodiazepines	99-113	CREB binding protein	Mus musculus	83-86
33301812-1	2021	AIMS: The 18 kDa translocator protein (TSPO) - also known as peripheral benzodiazepine receptor, is found to be expressed in lung epithelium and pneumocytes, which is closely associated with the mitochondrial permeability transition pore (mPTP) and apoptosis.	Benzodiazepines	72-86	translocator protein	Homo sapiens	17-37
33301812-1	2021	AIMS: The 18 kDa translocator protein (TSPO) - also known as peripheral benzodiazepine receptor, is found to be expressed in lung epithelium and pneumocytes, which is closely associated with the mitochondrial permeability transition pore (mPTP) and apoptosis.	Benzodiazepines	72-86	translocator protein	Homo sapiens	39-43
33221248-1	2021	The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a potential drug target for neuroinflammation and other disorders.	Benzodiazepines	68-82	translocator protein	Homo sapiens	4-24
33221248-1	2021	The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a potential drug target for neuroinflammation and other disorders.	Benzodiazepines	68-82	translocator protein	Homo sapiens	26-30
32453428-0	2021	Postmortem Analysis of Benzodiazepines in Human Bone by Gas Chromatography-Mass Spectrometry.	Benzodiazepines	23-38	gastrin	Homo sapiens	56-59
32453428-1	2021	A procedure based on gas chromatography-mass spectrometry was developed for the analysis of benzodiazepines (nordiazepam, oxazepam, lormetazepam, lorazepam, clonazepam, bromazepam and alprazolam) in postmortem human ribs.	Benzodiazepines	92-107	gastrin	Homo sapiens	21-24
33432839-3	2021	When taken during trauma other than ACS, benzodiazepines increase the risk of PTSS, but it is unknown if benzodiazepines increase the risk of PTSS in ACS.	Benzodiazepines	105-120	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	150-153
33432839-13	2021	Conclusions Notwithstanding short-term antianxiety effects during ACS, benzodiazepine use might increase the risk of ACS-induced PTSS with clinical significance, thereby compromising patients" quality of life and prognosis.	Benzodiazepines	71-85	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	117-120
32989663-1	2021	OBJECTIVE: The activation of microglia in various brain pathologies is accompanied by an increase in the expression of peripheral benzodiazepine receptor/18 kDa translocator protein (PBR/TSPO).	Benzodiazepines	130-144	translocator protein	Rattus norvegicus	183-186
32989663-1	2021	OBJECTIVE: The activation of microglia in various brain pathologies is accompanied by an increase in the expression of peripheral benzodiazepine receptor/18 kDa translocator protein (PBR/TSPO).	Benzodiazepines	130-144	translocator protein	Rattus norvegicus	187-191
32881658-1	2021	In 2020, it is already 43 years since Braestrup and Squires discovered 18 kDa translocator protein (TSPO), known until 2006 as "peripheral benzodiazepine receptor".	Benzodiazepines	139-153	translocator protein	Homo sapiens	78-98
32881658-1	2021	In 2020, it is already 43 years since Braestrup and Squires discovered 18 kDa translocator protein (TSPO), known until 2006 as "peripheral benzodiazepine receptor".	Benzodiazepines	139-153	translocator protein	Homo sapiens	100-104
32386503-4	2021	RESULTS: The results demonstrated that the neuropharmacological activities of beta-CBP may involve benzodiazepine/GABAergic receptors, since the pre-treatment of beta-CBP (200 mg/kg) associated with flumazenil (5 mg/kg, benzodiazepine receptor antagonist) and bicuculline (1 mg/kg, selective GABAA receptor antagonist) reestablished the anxiety parameters in the elevated plus-maze test, as well as the results of reduced latency to consume food in the novelty suppressed feeding test.	Benzodiazepines	99-113	CREB binding protein	Mus musculus	167-170
32386503-4	2021	RESULTS: The results demonstrated that the neuropharmacological activities of beta-CBP may involve benzodiazepine/GABAergic receptors, since the pre-treatment of beta-CBP (200 mg/kg) associated with flumazenil (5 mg/kg, benzodiazepine receptor antagonist) and bicuculline (1 mg/kg, selective GABAA receptor antagonist) reestablished the anxiety parameters in the elevated plus-maze test, as well as the results of reduced latency to consume food in the novelty suppressed feeding test.	Benzodiazepines	220-234	CREB binding protein	Mus musculus	83-86
33213094-2	2020	The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current emergency treatment including anticholinergics, benzodiazepines, and oxime reactivators.	Benzodiazepines	170-185	acetylcholinesterase	Danio rerio	87-107
33081988-1	2021	The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an alternative binding site for the benzodiazepine diazepam.	Benzodiazepines	106-120	translocator protein	Homo sapiens	4-31
33081988-1	2021	The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an alternative binding site for the benzodiazepine diazepam.	Benzodiazepines	106-120	translocator protein	Homo sapiens	33-37
32991989-0	2021	Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?	Benzodiazepines	14-28	peptidylprolyl isomerase G	Homo sapiens	56-59
33075418-1	2020	The translocator protein (TSPO), once known as peripheral-type benzodiazepine receptor, was reported to be related with several physiological functions.	Benzodiazepines	63-77	translocator protein	Mus musculus	4-24
33075418-1	2020	The translocator protein (TSPO), once known as peripheral-type benzodiazepine receptor, was reported to be related with several physiological functions.	Benzodiazepines	63-77	translocator protein	Mus musculus	26-30
32931814-13	2020	ERK inhibition could be used to manage anxiety symptoms in a benzodiazepine-sparing regimen for treatment of anxiety.	Benzodiazepines	61-75	mitogen-activated protein kinase 1	Mus musculus	0-3
33213189-7	2020	PLWH who had potentially inappropriate use of benzodiazepines had more inpatient (IRR: 1.46; 95% CI: 1.10, 1.94), outpatient (IRR: 1.14; 95% CI 1.02, 1.28), and emergency room (IRR: 1.32; 95% CI: 1.03, 1.68) visits.	Benzodiazepines	46-61	insulin receptor related receptor	Homo sapiens	82-85
33213189-7	2020	PLWH who had potentially inappropriate use of benzodiazepines had more inpatient (IRR: 1.46; 95% CI: 1.10, 1.94), outpatient (IRR: 1.14; 95% CI 1.02, 1.28), and emergency room (IRR: 1.32; 95% CI: 1.03, 1.68) visits.	Benzodiazepines	46-61	insulin receptor related receptor	Homo sapiens	126-129
33213189-7	2020	PLWH who had potentially inappropriate use of benzodiazepines had more inpatient (IRR: 1.46; 95% CI: 1.10, 1.94), outpatient (IRR: 1.14; 95% CI 1.02, 1.28), and emergency room (IRR: 1.32; 95% CI: 1.03, 1.68) visits.	Benzodiazepines	46-61	insulin receptor related receptor	Homo sapiens	126-129
33045469-4	2020	In the SPG7 animal model we evaluate the potential improvement of the motor defect, neuroinflammation and neurodegeneration by means of an mPTP inducer, the benzodiazepine Bz-423.	Benzodiazepines	157-171	SPG7, paraplegin matrix AAA peptidase subunit	Mus musculus	7-11
33252632-0	2020	Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10.	Benzodiazepines	36-51	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	124-128
32941854-11	2020	The presented findings may have clinical implications for the prediction of potential drug-drug interactions involving the asenapine-induced inhibition of metabolism of CYP1A2 substrates (e.g. caffeine, theophylline, melatonin, tricyclic antidepressants, phenacetin, propranolol) and iloperidone-induced inhibition of CYP3A4 substrates (e.g. antidepressants, benzodiazepines, atorvastatin, macrolide antibiotics, calcium channel antagonists).	Benzodiazepines	359-374	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	169-175
32980493-2	2020	Translocator protein 18kDa (TSPO), also known as peripheral benzodiazepine receptor, is a mitochondrial protein implicated in the synthesis of steroids in a variety of tissues.	Benzodiazepines	60-74	translocator protein	Homo sapiens	0-26
32980493-2	2020	Translocator protein 18kDa (TSPO), also known as peripheral benzodiazepine receptor, is a mitochondrial protein implicated in the synthesis of steroids in a variety of tissues.	Benzodiazepines	60-74	translocator protein	Homo sapiens	28-32
31845210-0	2020	Design and synthesis of benzodiazepine-1,2,3-triazole hybrid derivatives as selective butyrylcholinesterase inhibitors.	Benzodiazepines	24-53	butyrylcholinesterase	Homo sapiens	86-107
31845210-1	2020	A new series of compounds based on benzodiazepine-1,2,3-triazole were synthesized and evaluated as cholinesterase inhibitors by Ellman"s method.	Benzodiazepines	35-64	butyrylcholinesterase	Homo sapiens	99-113
32698131-1	2020	Despite being a highly conserved protein, the precise role of the mitochondrial translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), remains elusive.	Benzodiazepines	144-158	translocator protein	Mus musculus	102-106
28520370-0	2012	Diazepam Therapy and CYP2C19 Genotype Diazepam is a benzodiazepine with several clinical uses, including the management of anxiety, insomnia, muscle spasms, seizures, and alcohol withdrawal.	Benzodiazepines	52-66	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	21-28
33024171-10	2020	In contrast, a subset of benzodiazepines exacerbated p-tau cytotoxicity apparently via enhancing p-tau aggregation.	Benzodiazepines	25-40	microtubule associated protein tau	Homo sapiens	55-58
33024171-10	2020	In contrast, a subset of benzodiazepines exacerbated p-tau cytotoxicity apparently via enhancing p-tau aggregation.	Benzodiazepines	25-40	microtubule associated protein tau	Homo sapiens	99-102
32879488-1	2020	Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of gamma-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in the brain1-5.	Benzodiazepines	40-54	POU class 3 homeobox 3	Homo sapiens	180-188
32925928-12	2020	A concomitant use of benzodiazepines increased the odds for ED visits by 46% (OR 1.46, 1.41-1.52), infections by 44% (OR 1.44, 1.41-1.52), hospitalization by 12% (OR 1.12, 1.07-1.1), and death by 45% (OR 1.45, 1.37-1.53).	Benzodiazepines	21-36	olfactory receptor family 4 subfamily N member 1 pseudogene	Homo sapiens	78-85
32925928-12	2020	A concomitant use of benzodiazepines increased the odds for ED visits by 46% (OR 1.46, 1.41-1.52), infections by 44% (OR 1.44, 1.41-1.52), hospitalization by 12% (OR 1.12, 1.07-1.1), and death by 45% (OR 1.45, 1.37-1.53).	Benzodiazepines	21-36	olfactory receptor family 7 subfamily E member 11 pseudogene	Homo sapiens	163-170
32717030-3	2020	However, current benzodiazepine-derivative BET inhibitors (BETi) elicit disappointing responses and dose-limiting toxicity in relapsed/refractory lymphoma, potentially because of enrichment of high-risk molecular features and chemical backbone-associated toxicities.	Benzodiazepines	17-31	delta/notch-like EGF repeat containing	Mus musculus	43-46
32752296-0	2020	Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor.	Benzodiazepines	55-69	fatty acid binding protein 3, muscle and heart	Mus musculus	26-31
32752296-0	2020	Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor.	Benzodiazepines	55-69	forkhead box C1	Mus musculus	39-42
32752296-5	2020	MF1-promoted GABA currents were blocked by flumazenil (10 mum) treatment, suggesting that MF1 enhances receptor function via the benzodiazepine recognition site.	Benzodiazepines	129-143	forkhead box C1	Mus musculus	0-3
32752296-5	2020	MF1-promoted GABA currents were blocked by flumazenil (10 mum) treatment, suggesting that MF1 enhances receptor function via the benzodiazepine recognition site.	Benzodiazepines	129-143	forkhead box C1	Mus musculus	90-93
32752296-16	2020	Collectively, this suggests that MF1 is a mild enhancer of the GABAA receptor and exercises anti-epileptic effects through the receptor"s benzodiazepine recognition site in PILO-induced SE models.	Benzodiazepines	138-152	forkhead box C1	Mus musculus	33-36
32499732-5	2020	For example, benzodiazepines, including clonazepam and alprazolam, have been demonstrated to reduce the activity of corticotrophin releasing factor (CRF) neurons in the hypothalamus.	Benzodiazepines	13-28	corticotropin releasing hormone	Homo sapiens	116-147
31489462-8	2020	RESULTS: Patients treated with ECT showed higher mod-DBI values at TP0, mainly due to more frequent prescription of benzodiazepines (BZD), mood stabilizers (MS) and antipsychotic drugs (AP).	Benzodiazepines	116-131	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	53-56
31489462-8	2020	RESULTS: Patients treated with ECT showed higher mod-DBI values at TP0, mainly due to more frequent prescription of benzodiazepines (BZD), mood stabilizers (MS) and antipsychotic drugs (AP).	Benzodiazepines	133-136	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	53-56
31489462-9	2020	At the beginning of the inpatient treatment (TP0-TP1) there was an increase in BZD use (in both groups); in the ECT group MS were reduced and AP increased.	Benzodiazepines	79-82	transition protein 1	Homo sapiens	45-52
32511908-9	2020	A screen of 48 receptors identified the kappa-opioid receptor and to a lesser extent the micro-opioid receptor as molecular targets, with opioid receptor antagonist norbinaltorphimine reversing benzodiazepine induced reduction of microglial NO.	Benzodiazepines	194-208	opioid receptor kappa 1	Homo sapiens	40-61
32499386-11	2020	Risk was heightened in children initiating long-acting benzodiazepines versus SSRIs (adjusted IRR = 2.30 [95% CI: 1.08-4.91]).	Benzodiazepines	55-70	insulin receptor related receptor	Homo sapiens	94-97
32172519-5	2020	Translocator protein 18 kDa (TSPO) has been considered as one of the promising therapeutic biomarkers for neurological stress disorders (like PTSD, depression, anxiety, et al) without the benzodiazepine-like side effects.	Benzodiazepines	188-202	translocator protein	Homo sapiens	0-27
32172519-5	2020	Translocator protein 18 kDa (TSPO) has been considered as one of the promising therapeutic biomarkers for neurological stress disorders (like PTSD, depression, anxiety, et al) without the benzodiazepine-like side effects.	Benzodiazepines	188-202	translocator protein	Homo sapiens	29-33
32059939-6	2020	The anxiolytic-like effect of mast-L was attenuated by flumazenil (antagonist of benzodiazepine binding site) and WAY100635 (selective antagonist of 5-HT1A receptors) pretreatments.	Benzodiazepines	81-95	microtubule associated serine/threonine kinase-like	Mus musculus	30-36
32247113-8	2020	It is a potent general anesthetic that positively modulates agonist and benzodiazepine binding.	Benzodiazepines	72-86	amyloid beta precursor protein	Homo sapiens	6-7
31925934-11	2020	), the results indicate that Cx43 KD mice or wild-types injected with a shRNA-Cx43 in the amygdala, but not in the hippocampus, attenuated the anxiolytic-like effects of this benzodiazepine in the elevated plus maze.	Benzodiazepines	175-189	gap junction protein, alpha 3	Mus musculus	29-33
31925934-11	2020	), the results indicate that Cx43 KD mice or wild-types injected with a shRNA-Cx43 in the amygdala, but not in the hippocampus, attenuated the anxiolytic-like effects of this benzodiazepine in the elevated plus maze.	Benzodiazepines	175-189	gap junction protein, alpha 3	Mus musculus	78-82
32007495-3	2020	Benzodiazepines potentiate GABA responses by binding to GABAA receptors, which are mainly composed of alpha (1-3, 5), beta2, and gamma2 subunits.	Benzodiazepines	0-15	tetraspanin 7	Rattus norvegicus	102-115
31952869-12	2020	Management of SE with benzodiazepines and barbiturates may be more effective than lipids in cases of toxicity from intrathecal administration of bupivacaine.	Benzodiazepines	22-37	squalene epoxidase	Homo sapiens	14-16
32236428-3	2020	OBJECTIVE: To minimize the risk of delirium by implementing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) as the standard-of-care delirium assessment tool in the intensive care unit and by decreasing use of high-risk medications (ie, opioids and benzodiazepines).	Benzodiazepines	270-285	calmodulin 3	Homo sapiens	121-124
32105662-0	2020	The long-term but not short-term use of benzodiazepine impairs motoric function and upregulates amyloid beta in part through the suppression of translocator protein.	Benzodiazepines	40-54	translocator protein	Homo sapiens	144-164
32105662-4	2020	The aim of the current study is two-fold: 1) to determine a direct effect of TSPO (inhibition) on cBZD-induced Abeta42 and Abeta-associated molecules; Abeta-producing-protein presenilin-1 (PS1) and Abeta-degrading-enzyme neprilysin and 2) to determine whether Abeta42 upregulation and motoric deficit occur upon a long-term (cBZD) rather than a short-term BZD (sBZD) treatment.	Benzodiazepines	99-102	translocator protein	Homo sapiens	77-81
32007495-3	2020	Benzodiazepines potentiate GABA responses by binding to GABAA receptors, which are mainly composed of alpha (1-3, 5), beta2, and gamma2 subunits.	Benzodiazepines	0-15	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	118-135
32011968-1	2020	BACKGROUND: Concurrent use of opioids and benzodiazepines (COB) can lead to additive respiratory and central nervous system effects, putting patients at increased risk of fatal overdose.	Benzodiazepines	42-57	metabolism of cobalamin associated B	Homo sapiens	59-62
32054836-4	2020	Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABAARs and by an alpha1-to-alpha2GABAAR subunit switch, providing a mechanistic rationale for the analgesic action of the alpha2,3GABAAR benzodiazepine-site ligand L838,417 after nerve injury.	Benzodiazepines	222-236	brain derived neurotrophic factor	Homo sapiens	40-44
32054836-4	2020	Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABAARs and by an alpha1-to-alpha2GABAAR subunit switch, providing a mechanistic rationale for the analgesic action of the alpha2,3GABAAR benzodiazepine-site ligand L838,417 after nerve injury.	Benzodiazepines	222-236	neurotrophic receptor tyrosine kinase 2	Homo sapiens	45-49
32050449-5	2020	Prior work has demonstrated that inhibition of RUNX1 by the benzodiazepine (BDZ) Ro5-3335 synergizes with suberanilohydroxamic acid (SAHA) to activate HIV-1 transcription.	Benzodiazepines	60-74	RUNX family transcription factor 1	Homo sapiens	47-52
32050449-5	2020	Prior work has demonstrated that inhibition of RUNX1 by the benzodiazepine (BDZ) Ro5-3335 synergizes with suberanilohydroxamic acid (SAHA) to activate HIV-1 transcription.	Benzodiazepines	76-79	RUNX family transcription factor 1	Homo sapiens	47-52
32050449-9	2020	These findings shed further light on the mechanism by which RUNX proteins control HIV-1 transcription and suggest that BDZ compounds might be useful in activating HIV-1 transcription through STAT5 recruitment to the HIV-1 LTR.	Benzodiazepines	119-122	signal transducer and activator of transcription 5A	Homo sapiens	191-196
32011968-3	2020	From May 1, 2017, to December 4, 2017, a California Medicaid plan launched a COB-focused prescriber outreach intervention for members receiving recent opioid and benzodiazepine claims with the intent of decreasing concurrent use.	Benzodiazepines	162-176	metabolism of cobalamin associated B	Homo sapiens	77-80
31895969-0	2020	Let"s Talk About Benzodiazepine Use: Inpatient Psychiatric Nurses Initiating the Conversation.	Benzodiazepines	17-31	bone morphogenetic protein receptor type 2	Homo sapiens	6-10
31894752-4	2020	Receptors at most GABAergic synapses involve the gamma-2 subunit, which contributes to both phasic and tonic inhibition, and its presence assures benzodiazepine sensitivity.	Benzodiazepines	146-160	crystallin, gamma E	Rattus norvegicus	49-56
31818362-1	2020	Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain.	Benzodiazepines	54-68	translocator protein	Homo sapiens	0-20
31818362-1	2020	Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain.	Benzodiazepines	54-68	translocator protein	Homo sapiens	22-26
31386708-2	2019	Herein, we introduce different linkers to a BET bromodomain benzodiazepine ligand (I-BET762) to gauge its implications in the development of hybrid drugs, imaging probes and small molecule drug conjugates.	Benzodiazepines	60-74	delta/notch like EGF repeat containing	Homo sapiens	44-47
31171434-3	2019	Antiinflammatory drugs that interfere with the IL-1beta pathway, such as anakinra, can control benzodiazepine-refractory status epilepticus in animals, and there is recent proof-of-concept evidence for therapeutic effects in children with Febrile infection related epilepsy syndrome (FIRES).	Benzodiazepines	95-109	interleukin 1 beta	Homo sapiens	47-55
31720974-2	2019	Here, we utilized an integrated footprinting strategy incorporating both hydrogen-deuterium exchange (HDX) and hydroxyl radical footprinting (i.e., fast photochemical oxidation of proteins (FPOP)) for molecular-level characterization of the interaction of human bromodomain-containing protein 4 (BRD4) with a hydrophobic benzodiazepine inhibitor.	Benzodiazepines	321-335	bromodomain containing 4	Homo sapiens	262-294
31770388-11	2019	Benzodiazepine co-prescription was associated with increased risk of DRP (adjusted HR 2.96 [95% CI 1.97 to 4.43], p < 0.001), with evidence of a dose-response effect, but showed little evidence of an association with non-DRP (adjusted HR 0.91 [95% CI 0.66 to 1.25], p = 0.549).	Benzodiazepines	0-14	utrophin	Homo sapiens	69-72
31770388-11	2019	Benzodiazepine co-prescription was associated with increased risk of DRP (adjusted HR 2.96 [95% CI 1.97 to 4.43], p < 0.001), with evidence of a dose-response effect, but showed little evidence of an association with non-DRP (adjusted HR 0.91 [95% CI 0.66 to 1.25], p = 0.549).	Benzodiazepines	0-14	utrophin	Homo sapiens	221-224
31770388-14	2019	Concurrent benzodiazepine prescription also increased mortality risk after consideration of duration of OAT (adjusted HR for DRP with benzodiazepine concurrent prescription 3.34 [95% CI 2.14 to 5.20], p < 0.001).	Benzodiazepines	11-25	utrophin	Homo sapiens	125-128
31104504-0	2019	Association of Opioid and Benzodiazepine Use with Adverse Respiratory Events in Older Adults with COPD.	Benzodiazepines	26-40	COPD	Homo sapiens	98-102
31104504-4	2019	OBJECTIVES: The purpose of this study was to examine-among older adults with COPD-whether: 1) independent and concurrent use of opioid and benzodiazepine medications were associated with hospitalizations for respiratory events; and 2) this association was exacerbated by the presence of obstructive sleep apnea.	Benzodiazepines	139-153	COPD	Homo sapiens	77-81
31104504-10	2019	However, the adverse respiratory effects of concurrent opioid and benzodiazepine use were increased in patients with a high degree of COPD complexity.	Benzodiazepines	66-80	COPD	Homo sapiens	134-138
31104504-12	2019	CONCLUSIONS: Among older adults with COPD, use of opioid and benzodiazepine medications alone or in combination were associated with increased adverse respiratory events.	Benzodiazepines	61-75	COPD	Homo sapiens	37-41
31104504-14	2019	However, the adverse impact of dual opioid and benzodiazepine was greater in patients with high complexity COPD.	Benzodiazepines	47-61	COPD	Homo sapiens	107-111
31399842-2	2019	OBJECTIVE: The objective of this study was to compare SCAE incidence, types, and mortality between intravenous benzodiazepines (i.e., diazepam, lorazepam, and midazolam), dexmedetomidine, and propofol in the USA over 8 years regardless of the clinical setting where it was administered.	Benzodiazepines	111-126	DNA polymerase gamma, catalytic subunit	Homo sapiens	54-58
31399842-6	2019	The percentage of cases with one or more SCAE, the case mortality rate (%), and the incidence of each SCAE (per 106 days of sedative exposure), respectively, were benzodiazepines (14, 26, 13) [diazepam (13, 23, 31); lorazepam (15, 43, 14); midazolam (14, 20, 11)]; dexmedetomidine (40, 15, 13); and propofol (17, 39, 7).	Benzodiazepines	163-178	DNA polymerase gamma, catalytic subunit	Homo sapiens	102-106
31714426-7	2019	Secondary analyses explored neurocognitive correlates of positive BZD urine toxicology screens (TOX+) and specific BZD agents.	Benzodiazepines	66-69	thymocyte selection associated high mobility group box	Homo sapiens	96-99
31732737-11	2019	CONCLUSIONS: the association of PIM use and frailty seems to be restricted to drug classes, which can induce frailty symptoms (anticholinergics, benzodiazepines, z-substances and antipsychotics).	Benzodiazepines	145-160	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	32-35
31770388-14	2019	Concurrent benzodiazepine prescription also increased mortality risk after consideration of duration of OAT (adjusted HR for DRP with benzodiazepine concurrent prescription 3.34 [95% CI 2.14 to 5.20], p < 0.001).	Benzodiazepines	134-148	utrophin	Homo sapiens	125-128
31770388-15	2019	The main limitation of this study is the possibility that unmeasured confounding factors led to an association between benzodiazepine prescription and DRP that is not causal.	Benzodiazepines	119-133	utrophin	Homo sapiens	151-154
31770388-16	2019	CONCLUSIONS: In this study, co-prescription of benzodiazepine was specifically associated with increased risk of DRP in opioid-dependent individuals.	Benzodiazepines	47-61	utrophin	Homo sapiens	113-116
31601770-0	2019	Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions.	Benzodiazepines	57-71	shisa family member 7	Mus musculus	0-6
31601770-4	2019	Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs.	Benzodiazepines	64-78	shisa family member 7	Mus musculus	0-6
31601770-6	2019	Our data indicate that Shisa7 regulates GABAAR trafficking, function, and pharmacology and reveal a previously unknown molecular interaction that modulates benzodiazepine action in the brain.	Benzodiazepines	156-170	shisa family member 7	Mus musculus	23-29
31338540-13	2019	Both updated tools identified some pharmacological groups (benzodiazepines, PPIs, and opioids, among others) and certain health problems (insomnia, psychological disorders, and osteoarticular diseases) as factors of influence on PIM.	Benzodiazepines	59-74	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	229-232
31192335-5	2019	The MIP fibers were coated with a cross-linked bovine serum albumin (BSA) layer, resulting in RAMIP fibers that were used in the SPME of benzodiazepines directly from biological fluids.	Benzodiazepines	137-152	albumin	Homo sapiens	54-67
30954920-1	2019	The translocator protein 18 kDa (TSPO), initially characterized as peripheral benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated in cholesterol transport thereby affecting steroid hormone biosynthesis, as well as in general mitochondrial function related to bioenergetics, oxidative stress, and Ca2+ homeostasis.	Benzodiazepines	78-92	translocator protein	Mus musculus	33-37
31047979-8	2019	Furthermore, activation of the alpha1 subunit is not necessary for benzodiazepine hyperphagia and may instead contribute to the oromotor depressant and sedative properties of classic benzodiazepine agonists.	Benzodiazepines	183-197	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	31-37
31226874-9	2019	The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%).	Benzodiazepines	79-94	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	20-23
31226874-10	2019	Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed.	Benzodiazepines	95-110	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	76-79
31008713-3	2019	OBJECTIVE: The aim of this study was to evaluate the functionality, aesthetics, and quality of information of free or low-cost apps claiming to target alcohol, benzodiazepine, cocaine, crack/cocaine, crystal methamphetamine, and heroin use using the validated Mobile App Rating Scale (MARS) and critical content analysis.	Benzodiazepines	160-174	cathepsin B	Homo sapiens	127-131
30724097-1	2019	Ovarian cancer G protein-coupled receptor 1 (OGR1) is a recently deorphanized G protein-coupled receptor shown to signal in response to low extracellular pH ( pHo) or certain benzodiazepines.	Benzodiazepines	175-190	G protein-coupled receptor 68	Homo sapiens	0-43
30724097-1	2019	Ovarian cancer G protein-coupled receptor 1 (OGR1) is a recently deorphanized G protein-coupled receptor shown to signal in response to low extracellular pH ( pHo) or certain benzodiazepines.	Benzodiazepines	175-190	G protein-coupled receptor 68	Homo sapiens	45-49
30725256-10	2019	A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization.	Benzodiazepines	20-34	tumor protein p53	Homo sapiens	196-200
30725256-10	2019	A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization.	Benzodiazepines	20-34	tumor protein p53	Homo sapiens	218-221
31192221-2	2019	Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting.	Benzodiazepines	0-15	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	118-133
31192221-2	2019	Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting.	Benzodiazepines	0-15	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	135-142
31192221-2	2019	Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting.	Benzodiazepines	17-19	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	118-133
31192221-2	2019	Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting.	Benzodiazepines	17-19	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	135-142
31023995-3	2019	This study seeks to determine the prevalence of benzodiazepine use in a non-institutionalized older population over the age of 75 that is registered in Family Health Units (USF) in the region of Minho, Portugal, as well as to characterize these patients and understand the link between benzodiazepine use and chronic medication use, risk of falls, and level of physical and functional dependence.	Benzodiazepines	48-62	upstream transcription factor 1	Homo sapiens	173-176
30753076-4	2019	Finally, the co-crystal structure of GLP in complex with 12a provides the basis for the further development of benzodiazepine-based G9a/GLP inhibitors.	Benzodiazepines	111-125	euchromatic histone lysine methyltransferase 1	Homo sapiens	37-40
30753076-4	2019	Finally, the co-crystal structure of GLP in complex with 12a provides the basis for the further development of benzodiazepine-based G9a/GLP inhibitors.	Benzodiazepines	111-125	euchromatic histone lysine methyltransferase 2	Homo sapiens	132-135
30753076-4	2019	Finally, the co-crystal structure of GLP in complex with 12a provides the basis for the further development of benzodiazepine-based G9a/GLP inhibitors.	Benzodiazepines	111-125	euchromatic histone lysine methyltransferase 1	Homo sapiens	136-139
31058209-2	2019	Currently, GABAA receptor modulators such as benzodiazepines and barbiturates are used as medications for FSs with the aim of enhancing GABA-mediated inhibition of neuronal activity.	Benzodiazepines	45-60	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	11-16
30031883-3	2019	We have also previously demonstrated that the inverse benzodiazepine agonist MRK-016 (MRK) can protect against memory acquisition and consolidation errors in mice.	Benzodiazepines	54-68	mitogen-activated protein kinase kinase kinase 20	Mus musculus	77-84
30508732-0	2019	Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain.	Benzodiazepines	22-36	microtubule associated protein tau	Homo sapiens	57-60
30508732-2	2019	Although benzodiazepines have been suggested to increase the risk of incident dementia, their impact on tau pathology in vivo is unknown.	Benzodiazepines	9-24	microtubule associated protein tau	Homo sapiens	104-107
30508732-11	2019	Hence, future studies should focus on the impact of more prolonged or repeated benzodiazepine exposure on tau pathology and cognitive decline.	Benzodiazepines	79-93	microtubule associated protein tau	Homo sapiens	106-109
30031883-3	2019	We have also previously demonstrated that the inverse benzodiazepine agonist MRK-016 (MRK) can protect against memory acquisition and consolidation errors in mice.	Benzodiazepines	54-68	mitogen-activated protein kinase kinase kinase 20	Mus musculus	77-80
30391741-10	2019	These findings suggest that LPS enhances pentobarbital-induced LORR duration in mice treated with benzodiazepine via GABAA receptor activity.	Benzodiazepines	98-112	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	117-122
30834352-8	2019	The benzodiazepine zolpidem and local application of DAMGO to CA3 both mimicked the reduction in dominant frequency of CA3 slow gamma, but did not reduce the phase coupling.	Benzodiazepines	4-18	carbonic anhydrase 3	Rattus norvegicus	119-122
30454851-0	2019	Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.	Benzodiazepines	82-96	gephyrin	Rattus norvegicus	0-8
30454851-11	2019	Specifically, similar to the effect of BZD, the overexpression of DHHC12 in the BLA exerted a significant anxiolytic action, which was prevented by flumazenil.	Benzodiazepines	39-42	zinc finger DHHC-type palmitoyltransferase 12	Rattus norvegicus	66-72
30466968-5	2018	PURPOSE: The purpose is to investigate structure-activity relationships of flavonoids isolated from ACN and AKM, for binding to the benzodiazepine site (BZ-S) of gamma-aminobutyric acid type A (GABAA) receptor complex, and to search for anticonvulsant compounds without undesirable effects such as myorelaxation and sedation.	Benzodiazepines	132-146	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	194-199
30619611-7	2019	In contrast, several benzodiazepines positively modulated phenylephrine stimulation of a cAMP response element pathway by alpha1A- and alpha1B-ARs; however, this was shown to be caused by off-target inhibition of phosphodiesterases, known targets of diazepam.	Benzodiazepines	21-36	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	122-129
30546864-13	2018	Physicians should pay special attention before prescribing BZDs which keep being the major leading PIM.	Benzodiazepines	59-63	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	99-102
30205307-9	2018	Benzodiazepines were associated with longer LOS (beta = 4.94, 95% CI 2.86-7.03) and opioid treatment days (beta = 4.86, 95% CI 2.61-6.75), and more adjunctive medication treatment (aOR = 2.57, 95% CI 1.49-4.42).	Benzodiazepines	0-15	tubulin beta 3 class III	Homo sapiens	49-57
30205307-9	2018	Benzodiazepines were associated with longer LOS (beta = 4.94, 95% CI 2.86-7.03) and opioid treatment days (beta = 4.86, 95% CI 2.61-6.75), and more adjunctive medication treatment (aOR = 2.57, 95% CI 1.49-4.42).	Benzodiazepines	0-15	tubulin beta 3 class III	Homo sapiens	107-115
30112636-1	2018	This is the first study to examine the association between antidepressant and benzodiazepine use following a MOF and risk of subsequent fracture in those 65+.	Benzodiazepines	78-92	lysine acetyltransferase 8	Homo sapiens	109-112
29698632-2	2018	This protein has been identified as a peripheral binding site for benzodiazepines; in anamniotes, however, a second TSPO isoform that is absent in amniotes has been implicated in erythropoiesis.	Benzodiazepines	66-81	translocator protein	Danio rerio	116-120
30056012-10	2018	Use of benzodiazepines (46.7%) and omission of vitamin D (51.5%) were the most common PIM and PPO, respectively.	Benzodiazepines	7-22	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	86-89
30210295-5	2018	Herein, we investigated the effect of a BDZ (flurazepam) on the spontaneous and GABA-induced activity for wild-type (WT, alpha1beta2gamma2) and mutated (at the orthosteric binding site alpha1F64) GABAARs.	Benzodiazepines	40-43	adrenoceptor alpha 1D	Homo sapiens	121-138
30054195-6	2018	RESULTS: Seventeen months after starting the project, 66 seizures had been treated with a benzodiazepine in a median (p25-p75) time of 7.5 minutes (5 to 10), decreased from a baseline of 14 minutes (8-30) (P = 0.01).	Benzodiazepines	90-104	tubulin polymerization promoting protein	Homo sapiens	118-121
30054195-6	2018	RESULTS: Seventeen months after starting the project, 66 seizures had been treated with a benzodiazepine in a median (p25-p75) time of 7.5 minutes (5 to 10), decreased from a baseline of 14 minutes (8-30) (P = 0.01).	Benzodiazepines	90-104	PC4 and SFRS1 interacting protein 1	Homo sapiens	122-125
30030126-0	2018	Chronic benzodiazepine suppresses translocator protein and elevates amyloid beta in mice.	Benzodiazepines	8-22	translocator protein	Mus musculus	34-54
29698632-3	2018	Functional conservation of the central benzodiazepine-binding site located in the GABAA receptors has been demonstrated in anamniotes and amniotes alike; however, it was not previously demonstrated for TSPO.	Benzodiazepines	39-53	translocator protein	Danio rerio	202-206
29727298-11	2018	CONCLUSIONS: Experimental in silico and in vivo studies confirmed that the original Russian benzodiazepine phenazepam was the substrate of CYP3A4 isoenzyme.	Benzodiazepines	92-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
30294185-4	2018	Although a voluminous literature of studies is available evaluating the role of benzodiazepines (clonazepam and antidepressant (nortriptyline) in the treatment of RLS, but to the best of our knowledge, no comparative study is available comparing both of these drugs for efficacy and safety for the treatment of RLS QoL among 40 + years old women.	Benzodiazepines	80-95	RLS1	Homo sapiens	163-166
30065280-6	2018	Increasing GABA activity and resultant GABA receptor adaptations with prolonged use is postulated as a shared pharmacological mechanism between clozapine and benzodiazepines that underlie their association with withdrawal catatonia.	Benzodiazepines	158-173	GABA type A receptor-associated protein	Homo sapiens	39-52
30029159-4	2018	RESULTS: Among psychotherapy recipients, VA patients with markers of clinical complexity such as service connection for PTSD, comorbid bipolar or psychotic disorder, longer duration of PTSD diagnosis, and a benzodiazepine prescription for PTSD had lower odds of receiving a documented EBP.	Benzodiazepines	207-221	EBP cholestenol delta-isomerase	Homo sapiens	285-288
29533658-1	2018	The benzodiazepine benzomalvin A/D is a fungally derived specialized metabolite and inhibitor of the substance P receptor NK1, biosynthesized by a three-gene nonribosomal peptide synthetase cluster.	Benzodiazepines	4-18	tachykinin receptor 1	Homo sapiens	122-125
29875327-1	2018	TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral tissue binding sites for benzodiazepines, and was formerly called the peripheral benzodiazepine receptor.	Benzodiazepines	114-129	translocator protein	Homo sapiens	0-4
29600549-4	2018	Antiepileptic drugs remain the treatment of choice for PKD and episodic ataxia type 1, benzodiazepines are often useful for PNKD, and episodic ataxia type 2 benefits from acetazolamide regardless of the genetic etiology.	Benzodiazepines	87-102	PNKD metallo-beta-lactamase domain containing	Homo sapiens	124-128
29628509-1	2018	Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the anxiolytic effect of the benzodiazepine class of gamma-aminobutyric acid (GABA) receptor agonists and the recent discovery of anxiety-associated variants in the molecular components of inhibitory synapses.	Benzodiazepines	113-127	GABA type A receptor-associated protein	Homo sapiens	137-176
29732121-4	2018	We previously established a bump-&amp;-hole system for the BET bromodomains, pairing a leucine/alanine mutation with an ethyl-derived analogue of an established benzodiazepine scaffold.	Benzodiazepines	161-175	delta/notch like EGF repeat containing	Homo sapiens	59-62
29621539-9	2018	Our experimental findings and modeling suggest that AMIT preferentially blocks the open state of Kv7.1/KCNE1 channels by interacting with specific residues that were previously reported to be important for binding of other compounds, such as chromanol 293B and the benzodiazepine L7.	Benzodiazepines	265-279	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	97-102
29621539-9	2018	Our experimental findings and modeling suggest that AMIT preferentially blocks the open state of Kv7.1/KCNE1 channels by interacting with specific residues that were previously reported to be important for binding of other compounds, such as chromanol 293B and the benzodiazepine L7.	Benzodiazepines	265-279	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	103-108
29193847-3	2018	The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described.	Benzodiazepines	70-84	diazepam binding inhibitor	Mus musculus	12-38
29193847-3	2018	The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described.	Benzodiazepines	70-84	diazepam binding inhibitor	Mus musculus	40-43
29872302-4	2018	Recent findings have highlighted the importance of alpha1 containing GABAA receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments.	Benzodiazepines	133-147	adrenoceptor alpha 1D	Homo sapiens	51-57
29042451-0	2018	Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.	Benzodiazepines	56-71	G protein-coupled receptor 68	Homo sapiens	48-52
29042451-5	2018	Moreover, we recently discovered that the benzodiazepine lorazepam, more commonly recognized as an agonist of the gamma-aminobutyric acid A (GABAA) receptor, can function as an allosteric modulator of OGR1 and, similarly, can promote multiple signaling events.	Benzodiazepines	42-56	G protein-coupled receptor 68	Homo sapiens	201-205
29042451-6	2018	In this study, we demonstrated that different benzodiazepines exhibit a range of biases for OGR1, with sulazepam selectively activating the canonical Gs of the G protein signaling pathway, in heterologous expression systems, as well as in several primary cell types.	Benzodiazepines	46-61	G protein-coupled receptor 68	Homo sapiens	92-96
29325531-12	2018	The largest PIM costs arose from proton-pump inhibitors (34.4%), antipsychotics (21.0%) and benzodiazepines (18.7%).	Benzodiazepines	92-107	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	12-15
29184448-9	2017	Men were more likely than women to receive very high doses (RR 1.47, 95% CI 1.26-1.72), primarily due to BZDs (RR 2.12, 95% CI 2.07-2.16).	Benzodiazepines	105-109	ribonucleotide reductase regulatory subunit M2	Homo sapiens	111-115
29042260-5	2018	RESULTS: A clinically-approved benzodiazepine agonist (clorazepate; 10muM) increased time spent in the light whereas an inverse benzodiazepine agonist (FG-7142; 1, 10muM) produced the opposite response.	Benzodiazepines	31-45	latexin	Homo sapiens	70-73
29125291-1	2017	Compounds that can act on GABAA receptor subtype in a selective manner, without the side effects of classical benzodiazepine ligands, represent promising therapeutic tools in neurological disorder as well as for relief of pain or in comorbidity of anxiety states and depression.	Benzodiazepines	110-124	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	26-31
29211020-1	2017	Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys.	Benzodiazepines	216-230	translocator protein	Homo sapiens	119-139
29211020-1	2017	Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys.	Benzodiazepines	216-230	translocator protein	Homo sapiens	141-145
29138471-2	2017	The binding sites for the agonist GABA are located at the beta2+/alpha1- subunit interfaces and the modulatory site for benzodiazepines at alpha1+/gamma2-.	Benzodiazepines	120-135	adrenoceptor alpha 1D	Homo sapiens	139-145
29138471-2	2017	The binding sites for the agonist GABA are located at the beta2+/alpha1- subunit interfaces and the modulatory site for benzodiazepines at alpha1+/gamma2-.	Benzodiazepines	120-135	tryptophanyl-tRNA synthetase 1	Homo sapiens	147-153
29138471-5	2017	Point mutations were introduced in beta2 or gamma2 subunits at positions homologous to alpha1- benzodiazepine binding and GABA binding positions, respectively.	Benzodiazepines	95-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-40
29138471-5	2017	Point mutations were introduced in beta2 or gamma2 subunits at positions homologous to alpha1- benzodiazepine binding and GABA binding positions, respectively.	Benzodiazepines	95-109	adrenoceptor alpha 1D	Homo sapiens	87-93
28266783-2	2017	The separation of the studied designer benzodiazepines was achieved on C18 chromatographic column using gradient elution within 6 min without any significant matrix interferences.	Benzodiazepines	39-54	Bardet-Biedl syndrome 9	Homo sapiens	71-74
28426226-10	2017	Although SR extract contains flavones that are positive modulators of the benzodiazepine binding site of GABAA receptors (baicalein, wogonin, and baicalin), our behavioral study for the first time indicated that SR extract (a mixture of six flavones) did not elicit significant anxiolytic effect at the studied doses.	Benzodiazepines	74-88	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	105-110
28523461-6	2017	In multivariable-adjusted models, inappropriate use of benzodiazepines was significantly associated with older age (OR 1.7, 95% CI 1.1-2.7), middle education (OR 1.8, 95% CI 1.2-2.7), daily use (OR 1.4, 95% CI 1.1-2.0) and addiction awareness (OR 2.7, 95% CI 2.0-3.8).	Benzodiazepines	55-70	olfactory receptor family 10 subfamily R member 2	Homo sapiens	159-165
28523461-6	2017	In multivariable-adjusted models, inappropriate use of benzodiazepines was significantly associated with older age (OR 1.7, 95% CI 1.1-2.7), middle education (OR 1.8, 95% CI 1.2-2.7), daily use (OR 1.4, 95% CI 1.1-2.0) and addiction awareness (OR 2.7, 95% CI 2.0-3.8).	Benzodiazepines	55-70	olfactory receptor family 10 subfamily K member 2	Homo sapiens	195-201
28445782-3	2017	The alpha1-, beta2,3- and gamma2- subunits which combine to form a benzodiazepine sensitive GABAA receptor showed the most intense levels of staining and were the most common subunits found throughout the human thalamus especially in the ventral and posterior nuclear groups.	Benzodiazepines	67-81	adrenoceptor alpha 1D	Homo sapiens	4-10
28445782-3	2017	The alpha1-, beta2,3- and gamma2- subunits which combine to form a benzodiazepine sensitive GABAA receptor showed the most intense levels of staining and were the most common subunits found throughout the human thalamus especially in the ventral and posterior nuclear groups.	Benzodiazepines	67-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-20
28445782-3	2017	The alpha1-, beta2,3- and gamma2- subunits which combine to form a benzodiazepine sensitive GABAA receptor showed the most intense levels of staining and were the most common subunits found throughout the human thalamus especially in the ventral and posterior nuclear groups.	Benzodiazepines	67-81	tryptophanyl-tRNA synthetase 1	Homo sapiens	26-32
28377128-11	2017	Targeting NMDARs and AMPARs may provide novel strategies to treat benzodiazepine-refractory SE.	Benzodiazepines	66-80	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	21-27
28150939-2	2017	alpha2/alpha3-subtype GABAA receptors mediate the analgesic actions of benzodiazepines.	Benzodiazepines	71-86	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	0-13
28840991-6	2017	The overall percent agreement of the Triage TOX Drug Screen was 92.4-100% compared with UPLC-TMS; however, the Triage TOX Drug Screen results showed some discordant cases including acetaminophen, amphetamine, benzodiazepine, opiates, and tricyclic antidepressants.	Benzodiazepines	209-223	thymocyte selection associated high mobility group box	Homo sapiens	118-121
28334921-3	2017	Often in clinical testing an enzymatic hydrolysis step is implemented to increase the sensitivity of benzodiazepines by hydrolyzing beta-D-glucuronic acid from benzodiazepine-glucuronide conjugates in urine samples using the beta-Glucuronidase enzyme.	Benzodiazepines	101-116	glucuronidase beta	Homo sapiens	225-243
28334921-3	2017	Often in clinical testing an enzymatic hydrolysis step is implemented to increase the sensitivity of benzodiazepines by hydrolyzing beta-D-glucuronic acid from benzodiazepine-glucuronide conjugates in urine samples using the beta-Glucuronidase enzyme.	Benzodiazepines	101-115	glucuronidase beta	Homo sapiens	225-243
28334921-7	2017	The beta-Glucuronidase enzyme was used to hydrolyze the benzodiazepine analytes as well as resorufin beta-D-glucuronide.	Benzodiazepines	56-70	glucuronidase beta	Homo sapiens	4-22
29623189-3	2017	Benzodiazepines are also known to activate neurosteroidogenesis by binding to mitochondrial translocator protein (TSPO).	Benzodiazepines	0-15	translocator protein	Mus musculus	92-112
29623189-3	2017	Benzodiazepines are also known to activate neurosteroidogenesis by binding to mitochondrial translocator protein (TSPO).	Benzodiazepines	0-15	translocator protein	Mus musculus	114-118
28596835-1	2017	Benzodiazepines (BZDs), which bind with high affinity to gamma-aminobutyric acid type A receptors (GABAA-Rs) and potentiate the effects of GABA, are widely prescribed for anxiety, insomnia, epileptic discharge, and as anticonvulsants.	Benzodiazepines	0-15	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	99-104
28288483-9	2017	Topiramate, levetiracetam, zonisamide, and sodium valproate with benzodiazepine (clonazepam or nitrazepam) were found to be potential drugs for treating West syndrome besides adrenocorticotropic hormone, steroids, and vigabatrin.	Benzodiazepines	65-79	proopiomelanocortin	Homo sapiens	175-202
28192273-1	2017	Classical benzodiazepines, which are widely used as sedatives, anxiolytics and anticonvulsants, exert their therapeutic effects through interactions with heteropentameric GABAA receptors composed of two alpha, two beta and one gamma2 subunit.	Benzodiazepines	10-25	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	227-233
28174600-12	2017	RESULTS: There was a statistically significant (P &lt; 0.002) reduction of approximately 22% in the number of administered PRN benzodiazepines.	Benzodiazepines	127-142	cytosolic iron-sulfur assembly component 3	Homo sapiens	123-126
28174600-13	2017	Post-accreditation, the average number of PRN benzodiazepines administrations per patient, was 4.83 +- 2.1 compared to 6.19 +- 3.4 pre-accreditation.	Benzodiazepines	46-61	cytosolic iron-sulfur assembly component 3	Homo sapiens	42-45
28174600-15	2017	The highest average quantity of PRN benzodiazepines administered was during the time interval of 18-24 h. CONCLUSION: Accreditation may have a positive impact on the process of administering PRN benzodiazepine medications in psychiatric inpatients.	Benzodiazepines	36-51	cytosolic iron-sulfur assembly component 3	Homo sapiens	32-35
28174600-15	2017	The highest average quantity of PRN benzodiazepines administered was during the time interval of 18-24 h. CONCLUSION: Accreditation may have a positive impact on the process of administering PRN benzodiazepine medications in psychiatric inpatients.	Benzodiazepines	36-51	cytosolic iron-sulfur assembly component 3	Homo sapiens	191-194
28174600-15	2017	The highest average quantity of PRN benzodiazepines administered was during the time interval of 18-24 h. CONCLUSION: Accreditation may have a positive impact on the process of administering PRN benzodiazepine medications in psychiatric inpatients.	Benzodiazepines	36-50	cytosolic iron-sulfur assembly component 3	Homo sapiens	32-35
28174600-15	2017	The highest average quantity of PRN benzodiazepines administered was during the time interval of 18-24 h. CONCLUSION: Accreditation may have a positive impact on the process of administering PRN benzodiazepine medications in psychiatric inpatients.	Benzodiazepines	36-50	cytosolic iron-sulfur assembly component 3	Homo sapiens	191-194
28596835-1	2017	Benzodiazepines (BZDs), which bind with high affinity to gamma-aminobutyric acid type A receptors (GABAA-Rs) and potentiate the effects of GABA, are widely prescribed for anxiety, insomnia, epileptic discharge, and as anticonvulsants.	Benzodiazepines	17-21	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	99-104
28596835-4	2017	Unusual GABAA-R subunit expression and GABAA-R phosphorylation are induced by chronic BZD use.	Benzodiazepines	86-89	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	8-13
28596835-4	2017	Unusual GABAA-R subunit expression and GABAA-R phosphorylation are induced by chronic BZD use.	Benzodiazepines	86-89	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	39-44
27558677-0	2017	Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition.	Benzodiazepines	0-14	histone deacetylase 9	Homo sapiens	105-109
28123714-6	2017	For BDNF, a correlation was found in particular with the intake of benzodiazepine (P=0.0221).	Benzodiazepines	67-81	brain derived neurotrophic factor	Homo sapiens	4-8
27897203-6	2016	To test whether reductions in GABAergic signalling were causally involved in motor improvements, we treated animals during an early post-stroke period with a benzodiazepine inverse agonist, which impairs GABAA receptor function.	Benzodiazepines	158-172	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	204-209
27889507-0	2017	CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis.	Benzodiazepines	24-38	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-6
27889507-1	2017	OBJECTIVE: To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk.	Benzodiazepines	70-84	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	38-44
27889507-13	2017	CYP2C9*2 or *3 allele variants modified benzodiazepine-related fall risk.	Benzodiazepines	40-54	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-6
27889507-14	2017	Compared to nonusers, those carrying a CYP2C9*2 or *3 allele and using benzodiazepines had a 45% increased fall risk (HR, 1.45 95% CI, 1.21; 1.73), whereas CYP2C9*1 homozygotes using benzodiazepines had no increased fall risk (HR, 1.14; 95% CI, 0.90; 1.45).	Benzodiazepines	183-198	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	39-45
27889507-15	2017	Within benzodiazepine users, having a CYP2C9*2 or *3 allele was associated with an increased fall risk (HR, 1.35; 95% CI, 1.06; 1.72).	Benzodiazepines	7-21	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	38-44
27889507-17	2017	CONCLUSIONS: CYP2C9*2 and *3 allele variants modify benzodiazepine-related fall risk.	Benzodiazepines	52-66	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	13-19
27889507-20	2017	However, because the exact role of CYP2C9 in benzodiazepine metabolism is still unclear, additional research is warranted.	Benzodiazepines	45-59	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	35-41
30730638-7	2017	In addition, early symptoms of dementia can cause anx- iety, which may lead to benzodiazepine prescription in the period preceding diagnosis.The results of these studies do not, however, rule out a long-term risk of persistent cognitive impair- ment.	Benzodiazepines	79-93	chromosome 1 open reading frame 56	Homo sapiens	33-37
26626298-6	2016	LAO recipients were slightly younger and more likely than nonrecipients to have taken antibiotics, antidepressants, benzodiazepines, antihypertensives, sedatives, muscle relaxants, and short-acting opioids in the 60 days before surgery.	Benzodiazepines	116-131	interleukin 4 induced 1	Homo sapiens	0-3
27573669-4	2016	By combining in vivo sleep behavior, ex vivo electrophysiological recording from brain slices, and in silico molecular modeling, we demonstrate that (-)-alpha-pinene shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.	Benzodiazepines	231-245	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	225-230
27110106-2	2016	Although benzodiazepines (BZDs) can have adverse effects on respiratory response in COPD patients, these are the most common hypnotics.	Benzodiazepines	9-24	COPD	Homo sapiens	84-88
27999470-11	2016	The most commonly prescribed PIM was spironolactone in 15.7% patients followed by benzodiazepines in 15 patients.	Benzodiazepines	82-97	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-32
27490534-3	2016	Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA).	Benzodiazepines	96-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
27490534-3	2016	Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA).	Benzodiazepines	96-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-23
27490534-3	2016	Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA).	Benzodiazepines	113-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
27490534-3	2016	Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA).	Benzodiazepines	113-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-23
27110106-2	2016	Although benzodiazepines (BZDs) can have adverse effects on respiratory response in COPD patients, these are the most common hypnotics.	Benzodiazepines	26-30	COPD	Homo sapiens	84-88
27110106-3	2016	The aim of this study was to examine by meta-analysis the efficacy and safety of BZD to treat insomnia in COPD patients.	Benzodiazepines	81-84	COPD	Homo sapiens	106-110
27110106-5	2016	Studies were eligible if they compared the effects of BZD versus placebo on insomnia in COPD patients.	Benzodiazepines	54-57	COPD	Homo sapiens	88-92
27110106-16	2016	More randomized controlled trials are necessary to determine the potential effect of BZD in COPD patients with insomnia.	Benzodiazepines	85-88	COPD	Homo sapiens	92-96
26654202-9	2015	These ligands exhibited cooperativity with benzodiazepine binding across the CCK1R homodimeric complex, resulting in their ability to inhibit only a fraction of the saturable binding of a benzodiazepine radioligand, unlike other small molecule antagonists and agonists of this receptor.	Benzodiazepines	43-57	cholecystokinin A receptor	Homo sapiens	77-82
26715389-6	2016	First, benzodiazepines can decrease beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) and gamma-secretase activity and slow down the accumulation of Abeta oligomers in the brain.	Benzodiazepines	7-22	beta-secretase 1	Homo sapiens	36-89
26715389-6	2016	First, benzodiazepines can decrease beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) and gamma-secretase activity and slow down the accumulation of Abeta oligomers in the brain.	Benzodiazepines	7-22	beta-secretase 1	Homo sapiens	91-97
27804852-3	2016	For this purpose, a series of benzodiazepine derivatives were designed and synthesized as novel Hsp90 inhibitor.	Benzodiazepines	30-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	96-101
27804852-6	2016	In order to determine the anti-proliferative mechanism of the compounds, in silico molecular docking studies were performed between Hsp90 ATPase domain and the benzodiazepine derivatives.	Benzodiazepines	160-174	heat shock protein 90 alpha family class A member 1	Homo sapiens	132-137
27804852-10	2016	RESULTS: A representative Benzodiazepine derivative D5 binds Hsp90 with Kd value of 3,93 muM and with estimated free energy of binding -7.99 (kcal/mol).	Benzodiazepines	26-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
26518230-0	2016	ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis  Benzodiazepine Kit.	Benzodiazepines	122-136	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	137-140
26518230-4	2016	The purpose of this study was to evaluate whether the Immunalysis  Benzodiazepines ELISA kit could detect phenazepam, etizolam, pyrazolam, flubromazepam, diclazepam and its metabolite delorazepam.	Benzodiazepines	67-82	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	89-92
26518230-6	2016	This study found that these uncontrolled benzodiazepines cross-react sufficiently to produce a positive result with the Immunalysis  Benzodiazepine ELISA kit.	Benzodiazepines	41-56	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	154-157
26518230-6	2016	This study found that these uncontrolled benzodiazepines cross-react sufficiently to produce a positive result with the Immunalysis  Benzodiazepine ELISA kit.	Benzodiazepines	133-147	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	154-157
27956923-3	2016	The aim of this study was to assess the feasibility and the impact of a program including cognitive behavioural therapy, psychoeducation, and balneotherapy in a spa resort to facilitate long-term discontinuation of benzodiazepines.	Benzodiazepines	215-230	surfactant protein A2	Homo sapiens	161-164
26654202-9	2015	These ligands exhibited cooperativity with benzodiazepine binding across the CCK1R homodimeric complex, resulting in their ability to inhibit only a fraction of the saturable binding of a benzodiazepine radioligand, unlike other small molecule antagonists and agonists of this receptor.	Benzodiazepines	188-202	cholecystokinin A receptor	Homo sapiens	77-82
25968977-8	2015	Benzodiazepine diazepam partially prevented decrease in cell survival following exposure to CS and redox active iron containing media (saliva) while benzodiazepine clonazepam did not, indicating that this effect is TSPO-specific.	Benzodiazepines	0-14	translocator protein	Homo sapiens	215-219
26255765-6	2015	Functional studies evaluating the role of gamma2 and delta auxiliary subunits of GABAA receptors have made important advances in the understanding of the action of benzodiazepines, ethanol and neurosteroids.	Benzodiazepines	164-179	tryptophanyl-tRNA synthetase 1	Homo sapiens	42-58
26133962-6	2015	Increased extracellular GABA, through GAT1 blockade, enhances the affinity of GABAA receptors for benzodiazepine ligands, detected as an increase in [(11)C]flumazenil tissue distribution volume (VT).	Benzodiazepines	98-112	solute carrier family 6 member 1	Homo sapiens	38-42
26550826-3	2015	Using yeast-based screens against GPR68, here we identify the benzodiazepine drug lorazepam as a non-selective GPR68 positive allosteric modulator.	Benzodiazepines	62-76	G protein-coupled receptor 68	Mus musculus	34-39
26550826-3	2015	Using yeast-based screens against GPR68, here we identify the benzodiazepine drug lorazepam as a non-selective GPR68 positive allosteric modulator.	Benzodiazepines	62-76	G protein-coupled receptor 68	Mus musculus	111-116
26546136-11	2015	Non-COX-selective non-steroidal anti-inflammatory drugs in the Beers criteria and benzodiazepines in the PIM-Taiwan and PRISCUS criteria accounted for most leading PIMs.	Benzodiazepines	82-97	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-108
26013409-1	2015	PURPOSE: To investigate the association between the gamma-aminobutyric acid (GABA)ergic drugs, benzodiazepines or zopiclone and the occurrence of asthma exacerbations and subsequent mortality in a cohort of asthma patients.	Benzodiazepines	95-110	opioid receptor, mu 1	Mus musculus	111-113
26099997-6	2015	By inhibiting the mitochondrial Na+/Ca2+ exchanger using the benzodiazepine derivate, CGP37157 (CGP), a significant reduction in salinomycin neuronal toxicity has been observed.	Benzodiazepines	61-75	solute carrier family 8 member A1	Homo sapiens	32-50
26241038-9	2015	Since a large array of benzodiazepine analogues have been developed that interact with the peripheral benzodiazepine receptor, the mitochondrial TSPO might provide an important new target for treating AUDs.	Benzodiazepines	23-37	Translocator protein	Drosophila melanogaster	145-149
25843343-9	2015	Coadministration of a P2X7R antagonist with a benzodiazepine also provided seizure suppression in a model of drug-refractory status epilepticus when either treatment alone was minimally effective.	Benzodiazepines	46-60	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	22-27
26551691-1	2015	The mitochondrial 18-kDa translocator protein (TSPO) was originally discovered as a peripheral binding site of benzodiazepines to be later described as a core element of cholesterol trafficking between cytosol and mitochondria from which the current nomenclature originated.	Benzodiazepines	111-126	translocator protein	Homo sapiens	47-51
26551694-1	2015	The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands.	Benzodiazepines	162-177	translocator protein	Homo sapiens	58-62
26551694-1	2015	The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands.	Benzodiazepines	162-177	translocator protein	Homo sapiens	64-84
26551694-1	2015	The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands.	Benzodiazepines	162-177	translocator protein	Homo sapiens	86-89
26013409-3	2015	A nested case-control study probed the association between benzodiazepines or zopiclone and occurrence of asthma exacerbation (primary outcome) using conditional logistic regression.	Benzodiazepines	59-74	opioid receptor, mu 1	Mus musculus	75-77
26013409-6	2015	RESULTS: Current benzodiazepine use was associated with increased occurrence of asthma exacerbation (adj mOR 1.49; 95%CI [1.15, 1.93]; P = 0.001) as was current zopiclone use (adj mOR 1.59; 95%CI [1.37, 1.85]; P &lt; 0.001).	Benzodiazepines	17-31	opioid receptor, mu 1	Mus musculus	105-110
26013409-6	2015	RESULTS: Current benzodiazepine use was associated with increased occurrence of asthma exacerbation (adj mOR 1.49; 95%CI [1.15, 1.93]; P = 0.001) as was current zopiclone use (adj mOR 1.59; 95%CI [1.37, 1.85]; P &lt; 0.001).	Benzodiazepines	17-31	opioid receptor, mu 1	Mus musculus	180-185
25823763-0	2015	Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin.	Benzodiazepines	30-44	mitogen-activated protein kinase kinase kinase 20	Mus musculus	53-60
25823763-2	2015	We tested the ability of the inverse benzodiazepine agonist, MRK-016 (MRK) to protect against LPS-induced deficits in memory acquisition and consolidation, using a contextual fear conditioning (CFC) paradigm.	Benzodiazepines	37-51	mitogen-activated protein kinase kinase kinase 20	Mus musculus	61-68
25823763-2	2015	We tested the ability of the inverse benzodiazepine agonist, MRK-016 (MRK) to protect against LPS-induced deficits in memory acquisition and consolidation, using a contextual fear conditioning (CFC) paradigm.	Benzodiazepines	37-51	mitogen-activated protein kinase kinase kinase 20	Mus musculus	61-64
25307869-8	2015	Treatment with neuroleptics expressed in chlorpromazine equivalents and benzodiazepines expressed in diazepam equivalents correlated negatively with the number of oligodendrocytes in CA2/3 and CA4, respectively, suggesting that treatment with these drugs do not influence cell number.	Benzodiazepines	72-87	carbonic anhydrase 4	Homo sapiens	193-196
25784648-4	2015	However, there are indications that benzodiazepines promote neurosteroid synthesis via the 18-kDa cholesterol transporter protein (TSPO).	Benzodiazepines	36-51	translocator protein	Mus musculus	131-135
25864940-6	2015	For paroxysmal nonkinesigenic dyskinesia (PNKD), treatment with benzodiazepines is effective in many patients.	Benzodiazepines	64-79	PNKD metallo-beta-lactamase domain containing	Homo sapiens	42-46
25387562-6	2015	Despite treatment with benzodiazepines, her lower extremity rigidity persisted and CPK peaked at 47,906 U/L.	Benzodiazepines	23-38	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	83-86
25843781-10	2015	Results suggest significant caution is needed when ingesting GHB/GBL, particularly with alcohol, benzodiazepines, opiates, stimulants, and ketamine.	Benzodiazepines	97-112	MTOR associated protein, LST8 homolog	Homo sapiens	65-68
26061327-7	2015	Unfortunately, reintroduction of benzodiazepine was a source of rapid and high increase of CK, LDH, GADAb titer (up to 1:15,000), IGT, and SPS relapse.	Benzodiazepines	33-47	glutamate-ammonia ligase	Homo sapiens	100-105
25865415-1	2015	Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic inhibition through four subtypes (alpha1, alpha2, alpha3 and alpha5) of GABAA receptors (GABAAR).	Benzodiazepines	16-30	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	47-62
25903735-1	2015	Benzodiazepines increase vulnerability to infection through alpha1 subunit dependent Upsilon-amino-butyric-type-A (GABAA) signalling.	Benzodiazepines	0-15	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	115-120
25841786-2	2015	In the present study, we assessed the effects of prenatal stress and repeated benzodiazepine administration on dopamine receptor 2 expression in the nucleus accumbens of adult offspring.	Benzodiazepines	78-92	dopamine receptor D2	Rattus norvegicus	111-130
25865415-1	2015	Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic inhibition through four subtypes (alpha1, alpha2, alpha3 and alpha5) of GABAA receptors (GABAAR).	Benzodiazepines	16-30	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	129-154
25865415-1	2015	Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic inhibition through four subtypes (alpha1, alpha2, alpha3 and alpha5) of GABAA receptors (GABAAR).	Benzodiazepines	16-30	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	159-174
25635100-4	2015	Here we report crystal structures for Bacillus cereus TSPO (BcTSPO) down to 1.7 A resolution, including a complex with the benzodiazepine-like inhibitor PK11195.	Benzodiazepines	123-137	translocator protein	Homo sapiens	54-58
25865415-1	2015	Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic inhibition through four subtypes (alpha1, alpha2, alpha3 and alpha5) of GABAA receptors (GABAAR).	Benzodiazepines	16-30	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	176-182
25865415-4	2015	Here we use four lines of triple GABAAR point-mutated mice, which express only one benzodiazepine-sensitive GABAAR subtype at a time, to show that targeting only alpha2GABAARs achieves strong antihyperalgesia and reduced side effects (that is, no sedation, motor impairment and tolerance development).	Benzodiazepines	83-97	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	108-114
25653272-0	2015	Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD.	Benzodiazepines	0-14	COPD	Homo sapiens	81-85
25510230-5	2015	The currents were activated by THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and enhanced by the benzodiazepine diazepam (1 muM) and the general anesthetics etomidate and propofol (50 muM).	Benzodiazepines	105-119	latexin	Homo sapiens	132-135
25510230-5	2015	The currents were activated by THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and enhanced by the benzodiazepine diazepam (1 muM) and the general anesthetics etomidate and propofol (50 muM).	Benzodiazepines	105-119	latexin	Homo sapiens	192-195
25635101-3	2015	TSPO ligands, including benzodiazepine drugs, are implicated in regulating apoptosis and are extensively used in diagnostic imaging.	Benzodiazepines	24-38	translocator protein	Homo sapiens	0-4
25589712-1	2015	The mitochondrial 18kDa Translocation Protein (TSPO) was first identified in 1977 by its capability to bind benzodiazepines in peripheral tissues.	Benzodiazepines	108-123	translocator protein	Mus musculus	24-45
25589712-1	2015	The mitochondrial 18kDa Translocation Protein (TSPO) was first identified in 1977 by its capability to bind benzodiazepines in peripheral tissues.	Benzodiazepines	108-123	translocator protein	Mus musculus	47-51
25637438-5	2015	Recent data obtained from experiments in GABA(A)R point-mutated mice suggests dose-limiting sedative effects of classical nonspecific benzodiazepines as the underlying cause.	Benzodiazepines	134-149	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	41-49
26631092-7	2015	In all cases both benzodiazepines showed a higher effect on synapsin I phosphorylation than in glutamate release.	Benzodiazepines	18-33	synapsin I	Rattus norvegicus	60-70
25600369-4	2015	The romanticized quest for endozepines, endogenous ligands to the BZ-binding site, has uncovered a variety of ligands that might fulfill this role, including oleamides (Cravatt et al., 1995), nonpeptidic endozepines (Rothstein et al., 1992), and the protein diazepam-binding inhibitor (DBI) (Costa &amp; Guidotti, 1985).	Benzodiazepines	66-68	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	258-284
25600369-4	2015	The romanticized quest for endozepines, endogenous ligands to the BZ-binding site, has uncovered a variety of ligands that might fulfill this role, including oleamides (Cravatt et al., 1995), nonpeptidic endozepines (Rothstein et al., 1992), and the protein diazepam-binding inhibitor (DBI) (Costa &amp; Guidotti, 1985).	Benzodiazepines	66-68	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	286-289
25600373-6	2015	Contrastingly, actions of etomidate and benzodiazepines mediated via alpha2- and beta3-subunits modify rhythmic brain activity in vitro and in vivo at least in part by enhancing neuronal synchrony.	Benzodiazepines	40-55	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	69-86
25313240-10	2015	The use of benzodiazepines was associated with injurious falls when coupled with polypharmacy (aRR 1.40, 95% CI 1.04-1.87), but was associated with a greater number of falls (aIRR 1.32, 95% CI 1.05-1.65), independent of polypharmacy.	Benzodiazepines	11-26	arrestin beta 1	Homo sapiens	95-100
24845066-10	2014	The main difference in the prevalence of patients receiving a PIM according to the two versions of Beers" criteria involved prescriptions of benzodiazepines for insomnia or agitation, chronic use of non-benzodiazepine hypnotics, prescription of antipsychotics in people with dementia and oral iron at dosage higher than 325 mg/day.	Benzodiazepines	141-156	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-65
25500824-6	2015	Z-360, a benzodiazepine-derived CCK2R antagonist with subnanomolar affinity, was selected for complexation to (99m)Tc via multiple spacers.	Benzodiazepines	9-23	cholecystokinin B receptor	Homo sapiens	32-37
25437558-3	2014	In human neuroblastoma cells, either blockade of ARG1 or benzodiazepine-mediated activation of GABA-A receptors induced apoptosis and inhibited mitogenic signaling through AKT and MAPK.	Benzodiazepines	57-71	AKT serine/threonine kinase 1	Homo sapiens	172-175
24148353-0	2014	Impact of benzodiazepines on functional outcome and occurrence of pneumonia in stroke: evidence from VISTA.	Benzodiazepines	10-25	V-set immunoregulatory receptor	Homo sapiens	101-106
25540541-4	2014	Since alcohol and BZD act through the GABA receptor, we attempted to study the effect of Baclofen as maintenance treatment in a series of five cases with BZD dependence.	Benzodiazepines	18-21	GABA type A receptor-associated protein	Homo sapiens	38-51
25217555-0	2014	Rapid enzymatic hydrolysis using a novel recombinant beta-glucuronidase in benzodiazepine urinalysis.	Benzodiazepines	75-89	glucuronidase beta	Homo sapiens	53-71
25217555-4	2014	The assessment of a novel recombinant beta-glucuronidase for rapid hydrolysis in benzodiazepine urinalysis is presented.	Benzodiazepines	81-95	glucuronidase beta	Homo sapiens	38-56
25217555-12	2014	The unique potential of the IMCSzyme  recombinant beta-glucuronidase was demonstrated with fast benzodiazepine hydrolysis at RT leading to decreased processing time without the need for heat activation.	Benzodiazepines	96-110	glucuronidase beta	Homo sapiens	50-68
24845066-10	2014	The main difference in the prevalence of patients receiving a PIM according to the two versions of Beers" criteria involved prescriptions of benzodiazepines for insomnia or agitation, chronic use of non-benzodiazepine hypnotics, prescription of antipsychotics in people with dementia and oral iron at dosage higher than 325 mg/day.	Benzodiazepines	141-155	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-65
25207609-8	2014	The primary management paradigm for NBS is a structured opioid withdrawal program accompanied by centrally acting adjunctive therapy comprising antidepressants, benzodiazepines, and clonidine to target pain, anxiety, and depression, and prevent withdrawal effects, in addition to peripherally acting agents such as laxatives (e.g., osmotic laxatives and chloride channel activators) to control transient constipation.	Benzodiazepines	161-176	nibrin	Homo sapiens	36-39
24743966-5	2014	New benzodiazepine users were at significantly higher risk for outpatient respiratory exacerbations (RR 1.45, 95% CI 1.36-1.54) and emergency room visits for COPD or pneumonia (RR 1.92, 95% CI 1.69-2.18) compared to non-users.	Benzodiazepines	4-18	ribonucleotide reductase catalytic subunit M1	Homo sapiens	101-105
24743966-5	2014	New benzodiazepine users were at significantly higher risk for outpatient respiratory exacerbations (RR 1.45, 95% CI 1.36-1.54) and emergency room visits for COPD or pneumonia (RR 1.92, 95% CI 1.69-2.18) compared to non-users.	Benzodiazepines	4-18	ribonucleotide reductase catalytic subunit M1	Homo sapiens	177-181
24793772-4	2014	In addition, the benzodiazepine binding subtypes of the gamma-amino butyric acid type A (GABAA) receptor mediate a transient intracellular alkalinization when they are stimulated.	Benzodiazepines	17-31	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	89-94
24774720-0	2014	Rapid detoxification of benzodiazepine or Z-drugs dependence using acetylcholinesterase inhibitors.	Benzodiazepines	24-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-87
24774720-4	2014	Acetylcholinesterase inhibitors have been shown to reverse BZDs induced sedation.	Benzodiazepines	59-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
24774720-5	2014	We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence.	Benzodiazepines	240-244	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
24793772-6	2014	We show that the major benzodiazepine subtype (2alpha1, 2beta2, 1gamma2) is constitutively expressed in both undifferentiated P19 cells and retinoic acid (RA) differentiated P19 neurons.	Benzodiazepines	23-37	hemoglobin, beta adult minor chain	Mus musculus	57-71
23088350-6	2014	Regression models were used to determine the amount of variance in success in improving functional walking level, gains in walking speed, and declines in lower extremity, upper extremity, and cognitive impairment accounted for by alpha1 noradrenergic blockers + alpha2 noradrenergic agonists, benzodiazepines, voltage-sensitive sodium channel anticonvulsants, and alpha2delta voltage-sensitive calcium channel blockers.	Benzodiazepines	293-308	adrenoceptor alpha 1D	Homo sapiens	230-236
24786291-4	2014	CyPD binding affects ATP synthase activity, and most importantly, it decreases the threshold matrix Ca2+ required for PTP opening, in striking analogy with benzodiazepine 423, an apoptosis-inducing agent that also binds OSCP.	Benzodiazepines	156-170	ATP synthase peripheral stalk subunit OSCP	Homo sapiens	220-224
24500446-5	2014	In structural homology models beta3Y66 is the equivalent of gamma2T81 which is one of three critical residues lining the benzodiazepine binding site in the gamma2 subunit loop D, opposite to the "100H/R-site" benzodiazepine binding residue in GABAR alpha subunits.	Benzodiazepines	121-135	crystallin, gamma E	Rattus norvegicus	60-66
24500446-5	2014	In structural homology models beta3Y66 is the equivalent of gamma2T81 which is one of three critical residues lining the benzodiazepine binding site in the gamma2 subunit loop D, opposite to the "100H/R-site" benzodiazepine binding residue in GABAR alpha subunits.	Benzodiazepines	209-223	crystallin, gamma E	Rattus norvegicus	60-66
24067925-7	2014	Overall, these results indicate that YL-IPA08 is a more potent and selective TSPO ligand, which exerts antidepressant-like and anxiolytic-like effects on behaviors that are mediated by TSPO but does not cause the side effects that are typically associated with conventional benzodiazepines.	Benzodiazepines	274-289	translocator protein	Rattus norvegicus	77-81
24715673-1	2014	By binding to the benzodiazepine site, diazepam binding inhibitor (DBI) is associated with negative allosteric modulation (NAM) of GABAA receptors (Costa and Guidotti in Life Sci 49:325-344, 1991).	Benzodiazepines	18-32	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	39-65
24715673-1	2014	By binding to the benzodiazepine site, diazepam binding inhibitor (DBI) is associated with negative allosteric modulation (NAM) of GABAA receptors (Costa and Guidotti in Life Sci 49:325-344, 1991).	Benzodiazepines	18-32	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	67-70
24436974-10	2013	These data suggest that the stimulus effects of toluene may be at least partially mediated by benzodiazepine-like positive allosteric modulation of GABAA receptors containing alpha 2, 3 or 5 subunits.	Benzodiazepines	94-108	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	148-153
24367698-3	2013	Previous studies have demonstrated that both brain derived neurotrophic factor (BDNF) and c-Fos contribute to memory- and abuse-related processes that occur within the HIP, and their expression is altered in response to BZ exposure.	Benzodiazepines	220-222	brain derived neurotrophic factor	Mus musculus	45-78
24367698-3	2013	Previous studies have demonstrated that both brain derived neurotrophic factor (BDNF) and c-Fos contribute to memory- and abuse-related processes that occur within the HIP, and their expression is altered in response to BZ exposure.	Benzodiazepines	220-222	brain derived neurotrophic factor	Mus musculus	80-84
24367698-3	2013	Previous studies have demonstrated that both brain derived neurotrophic factor (BDNF) and c-Fos contribute to memory- and abuse-related processes that occur within the HIP, and their expression is altered in response to BZ exposure.	Benzodiazepines	220-222	FBJ osteosarcoma oncogene	Mus musculus	90-95
24262146-1	2013	Emerging evidence indicates that diazepam-binding inhibitor (DBI) mediates an endogenous benzodiazepine-mimicking (endozepine) effect on synaptic inhibition in the thalamic reticular nucleus (nRT).	Benzodiazepines	89-103	diazepam binding inhibitor	Mus musculus	33-59
24241181-4	2013	The structures of ten benzodiazepine type drugs and two non-benzodiazepine type drugs were then docked into the potential benzodiazepine binding site on the GABA(A)R. By analyzing the docking results, the critical residues His102 (alpha1), Phe77 (gamma2) and Phe100 (alpha1) were identified in the binding site.	Benzodiazepines	22-36	adrenoceptor alpha 1D	Homo sapiens	231-237
24241181-4	2013	The structures of ten benzodiazepine type drugs and two non-benzodiazepine type drugs were then docked into the potential benzodiazepine binding site on the GABA(A)R. By analyzing the docking results, the critical residues His102 (alpha1), Phe77 (gamma2) and Phe100 (alpha1) were identified in the binding site.	Benzodiazepines	22-36	adrenoceptor alpha 1D	Homo sapiens	267-273
24241181-4	2013	The structures of ten benzodiazepine type drugs and two non-benzodiazepine type drugs were then docked into the potential benzodiazepine binding site on the GABA(A)R. By analyzing the docking results, the critical residues His102 (alpha1), Phe77 (gamma2) and Phe100 (alpha1) were identified in the binding site.	Benzodiazepines	60-74	adrenoceptor alpha 1D	Homo sapiens	231-237
24241181-4	2013	The structures of ten benzodiazepine type drugs and two non-benzodiazepine type drugs were then docked into the potential benzodiazepine binding site on the GABA(A)R. By analyzing the docking results, the critical residues His102 (alpha1), Phe77 (gamma2) and Phe100 (alpha1) were identified in the binding site.	Benzodiazepines	60-74	adrenoceptor alpha 1D	Homo sapiens	231-237
24469112-1	2014	Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study.	Benzodiazepines	0-14	dihydrofolate reductase	Homo sapiens	41-45
24182621-7	2014	Midazolam, a short-acting benzodiazepine ligand, administered prior to stress prevented the increase in the p-ERK2 level in the BLA.	Benzodiazepines	26-40	mitogen-activated protein kinase 1	Homo sapiens	110-114
24262146-1	2013	Emerging evidence indicates that diazepam-binding inhibitor (DBI) mediates an endogenous benzodiazepine-mimicking (endozepine) effect on synaptic inhibition in the thalamic reticular nucleus (nRT).	Benzodiazepines	89-103	diazepam binding inhibitor	Mus musculus	61-64
24262146-4	2013	This effect was abolished by both a point mutation that inhibits classical benzodiazepine binding to GABAARs containing the alpha3 subunit (predominant in the nRT) and a chromosomal deletion that removes the Dbi gene.	Benzodiazepines	75-89	diazepam binding inhibitor	Mus musculus	208-211
24262146-5	2013	Thus, astrocytes are required for positive allosteric modulation via the alpha3 subunit benzodiazepine-binding site by DBI peptide family endozepines.	Benzodiazepines	88-102	diazepam binding inhibitor	Mus musculus	119-122
23666806-0	2013	Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?	Benzodiazepines	15-30	translocator protein	Homo sapiens	101-105
24436974-10	2013	These data suggest that the stimulus effects of toluene may be at least partially mediated by benzodiazepine-like positive allosteric modulation of GABAA receptors containing alpha 2, 3 or 5 subunits.	Benzodiazepines	94-108	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	175-190
24015967-2	2013	This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4).	Benzodiazepines	88-102	bromodomain containing 2	Homo sapiens	175-179
23928656-11	2013	It was also determined that the optimum MgCl2 concentration was 1.67 M. This method has shown the applicability of SERS for the detection of trace quantities of benzodiazepines in aqueous solutions as well as the optimization of the technique over a wide range of compounds.	Benzodiazepines	161-176	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	115-119
24015967-2	2013	This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4).	Benzodiazepines	88-102	bromodomain containing 3	Homo sapiens	181-185
24107192-3	2013	GlaxoSmithKline scientists have successfully optimized a class of benzodiazepines as inhibitors of BET bromodomains, without any prior knowledge of identified molecular targets.	Benzodiazepines	66-81	delta/notch like EGF repeat containing	Homo sapiens	99-102
24015967-2	2013	This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4).	Benzodiazepines	88-102	bromodomain containing 4	Homo sapiens	191-195
23524988-10	2013	For refractory RLS, the choice is to change to gabapentin or a different dopamine agonist, addition of a second agent like gabapentin or benzodiazepine to the existing drug or changing to a high-potency opioid or tramadol.	Benzodiazepines	137-151	RLS1	Homo sapiens	15-18
23787873-8	2013	Area p32 contains higher kainate, benzodiazepine (BZ), and serotonin (5-HT)1A but lower N-methyl-D-aspartate (NMDA) and alpha2 receptor densities.	Benzodiazepines	34-48	inhibitor of growth family member 2	Homo sapiens	5-8
23787873-8	2013	Area p32 contains higher kainate, benzodiazepine (BZ), and serotonin (5-HT)1A but lower N-methyl-D-aspartate (NMDA) and alpha2 receptor densities.	Benzodiazepines	50-52	inhibitor of growth family member 2	Homo sapiens	5-8
23752092-5	2013	The effect of MCP-1 was not dependent on the activation of its receptor CCR2, while it was blocked by flumazenil, the antagonist of benzodiazepine sites.	Benzodiazepines	132-146	C-C motif chemokine ligand 2	Homo sapiens	14-19
23752092-7	2013	Instead, in cultured spinal neurons MCP-1 induced a significant reduction of GABA-evoked currents, also through the benzodiazepine sites, indicating a region-specific mechanism of action.	Benzodiazepines	116-130	C-C motif chemokine ligand 2	Homo sapiens	36-41
23752092-9	2013	These findings provide the first evidence that MCP-1, acting on benzodiazepine sites, can modulate the GABA-evoked currents, depending on the subunit composition of GABA(A) receptor.	Benzodiazepines	64-78	C-C motif chemokine ligand 2	Homo sapiens	47-52
23478657-1	2013	OBJECTIVES: Benzodiazepines are used for treating anxiety, epilepsy, muscle spasm, alcohol withdrawal, palliation, insomnia, and sedation as they allosterically modulate gamma-amino-butyric acid type A (GABAA) receptors.	Benzodiazepines	12-27	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	203-208
23478657-13	2013	Macrophage and monocytes expressed benzodiazepine sensitive (alpha1-gamma2) GABAA receptors.	Benzodiazepines	35-49	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	61-74
23478657-13	2013	Macrophage and monocytes expressed benzodiazepine sensitive (alpha1-gamma2) GABAA receptors.	Benzodiazepines	35-49	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	76-81
23624119-3	2013	Previous studies have shown that changes in 18 kDa translocator protein (TSPO) expression (or function), a promising target for treating neurological disorders without benzodiazepine-like side effects, may correlate with PTSD.	Benzodiazepines	168-182	translocator protein	Mus musculus	73-77
23698091-0	2013	Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.	Benzodiazepines	111-125	BAI1-associated protein 3	Mus musculus	51-57
23698091-7	2013	By using a phenotype-based genetic association study, we identified two human BAIAP3 single-nucleotide polymorphism risk genotypes (AA for rs2235632, TT for rs1132358) that show a significant association with anxiety in women and, surprisingly, with benzodiazepine abuse in men.	Benzodiazepines	250-264	BAI1 associated protein 3	Homo sapiens	78-84
23698091-10	2013	Thus, Baiap3/BAIAP3 is gender specifically associated with anxiety and benzodiazepine use disorder, and the analysis of Baiap3/BAIAP3-related functions may help elucidate mechanisms underlying the development of both disorders.	Benzodiazepines	71-85	BAI1 associated protein 3	Homo sapiens	6-12
23698091-10	2013	Thus, Baiap3/BAIAP3 is gender specifically associated with anxiety and benzodiazepine use disorder, and the analysis of Baiap3/BAIAP3-related functions may help elucidate mechanisms underlying the development of both disorders.	Benzodiazepines	71-85	BAI1 associated protein 3	Homo sapiens	13-19
23524988-9	2013	For intermittent RLS, it is levodopa or dopamine agonists or low-potency opioids or benzodiazepines.	Benzodiazepines	84-99	RLS1	Homo sapiens	17-20
23751116-1	2013	An efficient, asymmetric synthesis of the 5-HT2C agonist vabicaserin in four chemical steps and 54% overall yield from commercially available benzodiazepine was achieved.	Benzodiazepines	142-156	5-hydroxytryptamine receptor 2C	Homo sapiens	42-48
23407108-8	2013	Mutations to the benzodiazepine-binding site (alpha1(H101C), gamma2(R144C), gamma2(R197C)) reduced or removed potentiation for all agonists, and an inverse agonist at the benzodiazepine site reduced responses to all agonists.	Benzodiazepines	17-31	tryptophanyl-tRNA synthetase 1	Homo sapiens	61-66
23727119-2	2013	Diazepam binding inhibitor (DBI) protein is a BZ site ligand expressed endogenously in the brain, but functional evidence for BZ-mimicking positive modulatory actions has been elusive.	Benzodiazepines	46-48	diazepam binding inhibitor	Mus musculus	0-32
23727119-6	2013	Together, these results indicate that DBI mediates endogenous nucleus-specific BZ-mimicking ("endozepine") roles to modulate nRT function and suppress thalamocortical oscillations.	Benzodiazepines	79-81	diazepam binding inhibitor	Mus musculus	38-41
23407108-8	2013	Mutations to the benzodiazepine-binding site (alpha1(H101C), gamma2(R144C), gamma2(R197C)) reduced or removed potentiation for all agonists, and an inverse agonist at the benzodiazepine site reduced responses to all agonists.	Benzodiazepines	17-31	tryptophanyl-tRNA synthetase 1	Homo sapiens	76-81
23407108-8	2013	Mutations to the benzodiazepine-binding site (alpha1(H101C), gamma2(R144C), gamma2(R197C)) reduced or removed potentiation for all agonists, and an inverse agonist at the benzodiazepine site reduced responses to all agonists.	Benzodiazepines	171-185	tryptophanyl-tRNA synthetase 1	Homo sapiens	61-66
23407108-8	2013	Mutations to the benzodiazepine-binding site (alpha1(H101C), gamma2(R144C), gamma2(R197C)) reduced or removed potentiation for all agonists, and an inverse agonist at the benzodiazepine site reduced responses to all agonists.	Benzodiazepines	171-185	tryptophanyl-tRNA synthetase 1	Homo sapiens	76-81
23984522-2	2013	In order to explore novel non-benzodiazepine sedative-hypnotic agents, HEA was treated as the lead compound.	Benzodiazepines	30-44	tetratricopeptide repeat domain 7	Mus musculus	71-74
23530243-3	2013	We show that CyPD binds the oligomycin sensitivity-conferring protein subunit of the enzyme at the same site as the ATP synthase inhibitor benzodiazepine 423 (Bz-423), that Bz-423 sensitizes the PTP to Ca(2+) like CyPD itself, and that decreasing oligomycin sensitivity-conferring protein expression by RNAi increases the sensitivity of the PTP to Ca(2+).	Benzodiazepines	139-153	peptidylprolyl isomerase F	Homo sapiens	13-17
23524167-2	2013	AIMS OF THE STUDY: The objective of the present study was to determine whether the GABAA/benzodiazepine complex or serotonin neurotransmission mediates the anxiolytic-like effect of lavender essential oil.	Benzodiazepines	89-103	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	83-88
23524167-5	2013	GABAA/benzodiazepine mediation was evaluated by pretreating the mice with the GABAA receptor antagonist picrotoxin before the marble burying test and [(3)H]flunitrazepam binding to the benzodiazepine site on the GABAA receptor.	Benzodiazepines	6-20	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	78-83
23524167-5	2013	GABAA/benzodiazepine mediation was evaluated by pretreating the mice with the GABAA receptor antagonist picrotoxin before the marble burying test and [(3)H]flunitrazepam binding to the benzodiazepine site on the GABAA receptor.	Benzodiazepines	6-20	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	78-83
23524167-5	2013	GABAA/benzodiazepine mediation was evaluated by pretreating the mice with the GABAA receptor antagonist picrotoxin before the marble burying test and [(3)H]flunitrazepam binding to the benzodiazepine site on the GABAA receptor.	Benzodiazepines	185-199	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	0-5
23360771-4	2013	Here we investigate how two distinct anxiolytic agents, buspirone, a partial 5-HT(1A) agonist, and diazepam, a benzodiazepine, influence phosphorylation of GluA1 subunits of AMPA receptors at the potentiating residue Ser(845) and Ser(831) in corticolimbic regions.	Benzodiazepines	111-125	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	156-161
23396146-1	2013	The aim of the present study was to examine the effects of nitric oxide synthase (NOS) inhibitors on responses, elicited by benzodiazepines (BZs) in a modified elevated plus-maze task in mice.	Benzodiazepines	124-139	nitric oxide synthase 1, neuronal	Mus musculus	59-80
23396146-1	2013	The aim of the present study was to examine the effects of nitric oxide synthase (NOS) inhibitors on responses, elicited by benzodiazepines (BZs) in a modified elevated plus-maze task in mice.	Benzodiazepines	141-144	nitric oxide synthase 1, neuronal	Mus musculus	59-80
23396146-2	2013	It was shown that acute doses of diazepam (DZ; 1 and 2 mg/kg) and flunitrazepam (FNZ; 0.05, 0.1 and 0.2 mg/kg) significantly increased the time of transfer latency (TL2) in a retention trial, thus confirming memory impairing effects of BZs.	Benzodiazepines	236-239	brachyury, T-box transcription factor T	Mus musculus	165-168
23530243-3	2013	We show that CyPD binds the oligomycin sensitivity-conferring protein subunit of the enzyme at the same site as the ATP synthase inhibitor benzodiazepine 423 (Bz-423), that Bz-423 sensitizes the PTP to Ca(2+) like CyPD itself, and that decreasing oligomycin sensitivity-conferring protein expression by RNAi increases the sensitivity of the PTP to Ca(2+).	Benzodiazepines	139-153	peptidylprolyl isomerase F	Homo sapiens	214-218
23266380-0	2013	Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells.	Benzodiazepines	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
23426784-2	2013	The present study used midazolam, a benzodiazepine class anesthesic, to pharmacologically intervene in the expression of TRPM7 and to inhibit cancer cell proliferation.	Benzodiazepines	36-50	transient receptor potential cation channel subfamily M member 7	Homo sapiens	121-126
23294828-0	2013	Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.	Benzodiazepines	35-49	vitamin D receptor	Homo sapiens	120-138
23294828-3	2013	We previously reported that benzodiazepine derivatives designed as LXXLL peptide mimetics inhibited the interaction of VDR and coactivators, and reduced VDR transcription.	Benzodiazepines	28-42	vitamin D receptor	Homo sapiens	119-122
23294828-3	2013	We previously reported that benzodiazepine derivatives designed as LXXLL peptide mimetics inhibited the interaction of VDR and coactivators, and reduced VDR transcription.	Benzodiazepines	28-42	vitamin D receptor	Homo sapiens	153-156
23266380-11	2013	In conclusion, this is the first study showing an inhibitory action of benzodiazepines on adenosine A(2B) receptor mediated interleukin-8 production in human mast (HMC1) cells.	Benzodiazepines	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
23266380-3	2013	Therefore, we investigated the effects of benzodiazepines on adenosine A(2B) receptor mediated interleukin-8 production in human mast cell leukaemia (HMC1) cells by an enzyme linked immunosorbent assay.	Benzodiazepines	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
24024214-4	2013	Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P = 0.009) and L-DOPA (P < 0.001) and significant reductions in patients taking benzodiazepines (P = 0.020).	Benzodiazepines	231-246	brain derived neurotrophic factor	Homo sapiens	81-85
23345228-2	2013	Recent studies have shown that the ligands of translocator protein (TSPO, 18 kDa), a peripheral receptor for benzodiazepine, modulate inflammatory pain.	Benzodiazepines	109-123	translocator protein	Rattus norvegicus	46-66
23345228-2	2013	Recent studies have shown that the ligands of translocator protein (TSPO, 18 kDa), a peripheral receptor for benzodiazepine, modulate inflammatory pain.	Benzodiazepines	109-123	translocator protein	Rattus norvegicus	68-72
29403788-2	2012	The three benzodiazepine compounds were separated on a reversed-phase C18 column at 50  C using a mobile phase containing 25% acetonitrile, 45% methanol and 30% ammonium acetate (0.05 M).	Benzodiazepines	10-24	Bardet-Biedl syndrome 9	Homo sapiens	70-73
23392308-4	2013	This study was performed to elucidate the role of mGluRs in benzodiazepine dependence.	Benzodiazepines	60-74	glutamyl-tRNA synthetase 2, mitochondrial	Mus musculus	50-56
23392308-10	2013	Our findings suggest that the reduction in the expression of group II mGluRs subunits may be involved in the development of benzodiazepine dependence.	Benzodiazepines	124-138	glutamyl-tRNA synthetase 2, mitochondrial	Mus musculus	70-76
23143088-1	2012	UNLABELLED: The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the gamma-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may confound interpretation of (11)C-flumazenil PET in epilepsy.	Benzodiazepines	123-137	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	291-305
23143088-1	2012	UNLABELLED: The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the gamma-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may confound interpretation of (11)C-flumazenil PET in epilepsy.	Benzodiazepines	123-137	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	307-311
22771461-9	2012	The sleep-promoting effects and changes in c-Fos induced by magnolol were reversed by flumazenil, an antagonist at the benzodiazepine site of the GABA(A) receptor.	Benzodiazepines	119-133	FBJ osteosarcoma oncogene	Mus musculus	43-48
23091016-4	2012	BZs bind at the interface between an alpha and gamma subunit of GABA(A)Rs, preferentially enhancing synaptic receptors largely composed of alpha(1-3, 5), beta3, and gamma2 subunits.	Benzodiazepines	0-3	tryptophanyl-tRNA synthetase 1	Homo sapiens	165-171
22917472-9	2012	Within the GABA-A/benzodiazepine ligand data set, PLS models of high predictivity resulted for our QM-based property fields, providing novel insights into key features of the SAR for two receptor subtypes and cross-receptor selectivity of the ligands.	Benzodiazepines	18-32	sarcosine dehydrogenase	Homo sapiens	175-178
22981367-3	2012	In contrast to the anxioselective profile displayed in preclinical models, compounds such as bretazenil, TPA023, and MRK 409 produced benzodiazepine-like side effects (sedation, dizziness) in Phase I studies, whereas alpidem and ocinaplon exhibited many of the characteristics of an anxioselective in the clinic.	Benzodiazepines	134-148	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	117-120
21919687-3	2012	In the current study, in vitro and in vivo inhibition effects of benzodiazepine drugs, diazepam and midazolam, on human erythrocytes carbonic anhydrase I and II isozymes were investigated.	Benzodiazepines	65-79	carbonic anhydrase 1	Homo sapiens	133-153
22763624-5	2012	To elucidate the alpha subunit(s) responsible for the reward-enhancing effects of benzodiazepines, we examined mice carrying a histidine-to-arginine point mutation in the alpha1, alpha2, or alpha3 subunit, which renders the targeted subunit nonresponsive to diazepam, other benzodiazepines and zolpidem.	Benzodiazepines	82-97	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	179-196
22014182-3	2012	Besides interacting with the benzodiazepine site associated with GABA(A) receptors, some benzodiazepines act as agonists of translocator protein (18 kDa) (TSPO) to enhance the synthesis of steroids, including neurosteroids with positive modulatory actions on GABA(A) receptors.	Benzodiazepines	29-43	translocator protein	Mus musculus	155-159
22912405-5	2012	Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFbeta directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos.	Benzodiazepines	12-26	RUNX family transcription factor 1	Danio rerio	186-191
22677273-1	2012	The gabra5 gene is associated with pharmacological properties (myorelaxant, amnesic, anxiolytic) of benzodiazepines.	Benzodiazepines	100-115	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5	Mus musculus	4-10
22197254-7	2012	The performance of the C18-silica glass 96-blade SPME system was evaluated for high-throughput analysis of benzodiazepines from phosphate-buffered saline solution (PBS) and human plasma, and the reusability, repeatability, and validity of the system were evaluated.	Benzodiazepines	107-122	Bardet-Biedl syndrome 9	Homo sapiens	23-26
22723702-7	2012	Moreover, the alpha3 GABA(A)R-selective benzodiazepine site agonist and anxiolytic compound TP003 increases tonic currents and dampens excitability markedly in wild-type BLA principal cells but fails to do so in alpha3KO BLA cells.	Benzodiazepines	40-54	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	21-29
22467877-4	2012	When all six residues within CCK1R were mutated to corresponding CCK2R residues, benzodiazepine selectivity was reversed, yet peptide binding selectivity was unaffected.	Benzodiazepines	81-95	cholecystokinin A receptor	Homo sapiens	29-34
22467877-4	2012	When all six residues within CCK1R were mutated to corresponding CCK2R residues, benzodiazepine selectivity was reversed, yet peptide binding selectivity was unaffected.	Benzodiazepines	81-95	cholecystokinin B receptor	Homo sapiens	65-70
22348610-1	2012	The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR).	Benzodiazepines	98-113	translocator protein	Homo sapiens	25-45
22348610-1	2012	The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR).	Benzodiazepines	98-113	translocator protein	Homo sapiens	47-51
22348610-1	2012	The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR).	Benzodiazepines	98-113	translocator protein	Homo sapiens	216-250
22348610-1	2012	The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR).	Benzodiazepines	98-113	translocator protein	Homo sapiens	252-255
22912405-0	2012	Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction.	Benzodiazepines	18-32	RUNX family transcription factor 1	Danio rerio	126-131
22912405-0	2012	Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction.	Benzodiazepines	18-32	core-binding factor subunit beta	Danio rerio	132-139
22912405-5	2012	Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFbeta directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos.	Benzodiazepines	12-26	RUNX family transcription factor 1	Danio rerio	81-86
22912405-5	2012	Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFbeta directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos.	Benzodiazepines	12-26	core-binding factor subunit beta	Danio rerio	91-98
22912405-5	2012	Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFbeta directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos.	Benzodiazepines	12-26	RUNX family transcription factor 1	Danio rerio	117-122
22912405-5	2012	Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFbeta directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos.	Benzodiazepines	12-26	core-binding factor subunit beta	Danio rerio	123-127
22666188-5	2012	BZ has both anxiolytic and sedative actions, which are mediated through GABA(A) receptors containing alpha2/alpha3 and alpha1 subunits, respectively.	Benzodiazepines	0-2	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	101-125
22189673-1	2012	AIM: (1) To describe the prevalence of benzodiazepine use in Belgian nursing homes, with specific attention to indications and dosages.	Benzodiazepines	39-53	crystallin beta-gamma domain containing 1	Homo sapiens	0-7
22226778-2	2012	Here we show the feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and anticonvulsant.	Benzodiazepines	153-167	prostaglandin D2 synthase (brain)	Mus musculus	78-84
22014182-3	2012	Besides interacting with the benzodiazepine site associated with GABA(A) receptors, some benzodiazepines act as agonists of translocator protein (18 kDa) (TSPO) to enhance the synthesis of steroids, including neurosteroids with positive modulatory actions on GABA(A) receptors.	Benzodiazepines	89-104	translocator protein	Mus musculus	155-159
22014182-14	2012	Enhanced neurosteroidogenesis may also be a factor in the actions of other benzodiazepines, even those that only weakly interact with TSPO.	Benzodiazepines	75-90	translocator protein	Mus musculus	134-138
21748330-2	2012	In this paper, 60 benzodiazepine derivatives displaying potent activities against ET(A) and ET(B) subtypes of endothelin receptor were selected to establish the 3D-QSAR models using CoMFA and CoMSIA approaches.	Benzodiazepines	18-32	endothelin receptor type A	Homo sapiens	82-87
21748330-2	2012	In this paper, 60 benzodiazepine derivatives displaying potent activities against ET(A) and ET(B) subtypes of endothelin receptor were selected to establish the 3D-QSAR models using CoMFA and CoMSIA approaches.	Benzodiazepines	18-32	endothelin receptor type B	Homo sapiens	92-97
22720038-6	2012	Nitrazepam, an agonist at the benzodiazepine-binding site of the GABA(A) receptor, which potentiates the action of GABA, produced a dose-dependent increase in TST immobility time in the Usp46 mutant mice without affecting general behaviors.	Benzodiazepines	30-44	ubiquitin specific peptidase 46	Mus musculus	186-191
22169949-7	2012	Muscimol, a GABA(A) receptor agonist, and diazepam, an agonist to benzodiazepine-binding site of GABA(A) receptor, blocked retention trial-induced ERK phosphorylation and impaired memory retrieval.	Benzodiazepines	66-80	mitogen-activated protein kinase 1	Mus musculus	147-150
22192380-8	2012	COMT KO mice showed increased anxiety, but benzodiazepine sensitivity was affected by COMT genotype.	Benzodiazepines	43-57	catechol-O-methyltransferase	Mus musculus	86-90
22305493-1	2012	A series of benzodiazepine antagonists of the human ghrelin receptor GHSR1a were synthesized and their antagonism and metabolic stability were evaluated.	Benzodiazepines	12-26	ghrelin and obestatin prepropeptide	Rattus norvegicus	52-59
22209795-3	2012	The present study investigated the ability of the specific TSPO ligands, the isoquinoline carboxamide PK11195 and benzodiazepine Ro5-4864, on neutrophil recruitment promoted by the N-formylmethionyl-leucyl-phenylalanine peptide (fMLP), an agonist of G-protein coupled receptor (GPCR).	Benzodiazepines	114-128	translocator protein	Homo sapiens	59-63
22204484-1	2012	The classical benzodiazepines (Bz) constitute a well-known class of therapeutics displaying hypnotic, anxiolytic and anticonvulsant effects acting upon a specific binding site (BzR) belonging to the GABAA receptor complex.	Benzodiazepines	14-29	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	199-204
22204484-1	2012	The classical benzodiazepines (Bz) constitute a well-known class of therapeutics displaying hypnotic, anxiolytic and anticonvulsant effects acting upon a specific binding site (BzR) belonging to the GABAA receptor complex.	Benzodiazepines	31-33	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	199-204
22204484-2	2012	Their usefulness, however, is limited by a broad range of side effects; consequently the fact that the action of GABA with the receptor complex could be allosterically modulated by a wide variety of chemical entities, made the Bz binding site, from late eighties to nowdays, the target of extensive research programmes directed to the identification of new ligands displaying varying degrees of affinity- and efficacy-selectivity for the different GABAA/BzR-subtypes.	Benzodiazepines	227-229	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	448-453
22137933-0	2012	Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.	Benzodiazepines	0-15	delta/notch like EGF repeat containing	Homo sapiens	101-104
22119506-8	2012	The concentrations of the benzodiazepines in the method span a broad range varying from the lowest concentration of 0.005 muM for flunitrazepam to the highest of 20 muM for oxazepam.	Benzodiazepines	26-41	latexin	Homo sapiens	122-125
22119506-8	2012	The concentrations of the benzodiazepines in the method span a broad range varying from the lowest concentration of 0.005 muM for flunitrazepam to the highest of 20 muM for oxazepam.	Benzodiazepines	26-41	latexin	Homo sapiens	165-168
22397285-13	2011	Anticonvulsants, benzodiazepines and opioides can be given to patients who are refractory to dopaminergic therapy, those suffering from RLS with emphasized painful sensory component and those with RLS connected with insomnia.	Benzodiazepines	17-32	RLS1	Homo sapiens	136-139
22384252-2	2012	To study GABA signaling in vivo, we recently used a novel positron emission tomography (PET) paradigm measuring the change in binding of the benzodiazepine (BDZ) site radiotracer [(11)C]flumazenil associated with increases in extracellular GABA induced via GABA membrane transporter (GAT1) blockade with tiagabine.	Benzodiazepines	141-155	solute carrier family 6 member 1	Homo sapiens	284-288
22384252-2	2012	To study GABA signaling in vivo, we recently used a novel positron emission tomography (PET) paradigm measuring the change in binding of the benzodiazepine (BDZ) site radiotracer [(11)C]flumazenil associated with increases in extracellular GABA induced via GABA membrane transporter (GAT1) blockade with tiagabine.	Benzodiazepines	157-160	solute carrier family 6 member 1	Homo sapiens	284-288
22397285-13	2011	Anticonvulsants, benzodiazepines and opioides can be given to patients who are refractory to dopaminergic therapy, those suffering from RLS with emphasized painful sensory component and those with RLS connected with insomnia.	Benzodiazepines	17-32	RLS1	Homo sapiens	197-200
21880742-4	2011	GABA(A)R alpha3 gephyrin binding-site mutants were unable to co-localize with endogenous gephyrin in transfected hippocampal neurons, despite being able to traffic to the cell membrane and form functional benzodiazepine-responsive GABA(A)Rs in recombinant systems.	Benzodiazepines	205-219	gephyrin	Homo sapiens	16-24
21715105-6	2011	In multivariate analysis, prolonged BZD use was associated with categorized overall CTQ-scores (OR 1.5), HCV-seropositivity (OR 4.0), psychiatric family history (OR 2.3), and opioid dose (mg methadone equivalents, OR 1.010).	Benzodiazepines	36-39	olfactory receptor family 3 subfamily A member 1	Homo sapiens	125-131
21930425-0	2011	Binding of benzodiazepine drugs to bovine serum albumin: a second derivative spectrophotometric study.	Benzodiazepines	11-25	albumin	Homo sapiens	42-55
21930425-1	2011	The binding constants (K values) of three benzodiazepine drugs to bovine serum albumin were determined by a second derivative spectrophotometric method.	Benzodiazepines	42-56	albumin	Homo sapiens	73-86
21930380-4	2011	We designed and synthesized a series of benzodiazepine-based SENP1 inhibitors, and they showed inhibitory activity as good as IC(50)=9.2muM (compound 38).	Benzodiazepines	40-54	SUMO specific peptidase 1	Homo sapiens	61-66
22018687-8	2011	Taken together, these findings suggest that blockade of TRPV1 might be a functional tool to prevent the risks associated with the long-term use of benzodiazepines.	Benzodiazepines	147-162	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-61
22654814-8	2011	Moreover, novel drugs interfering with neurosteroidogenesis such as ligands of the translocator protein (18 kDa) may represent an attractive pharmacological option for novel anxiolytics which lack the unwarranted side effects of benzodiazepines.	Benzodiazepines	229-244	translocator protein	Homo sapiens	83-103
21439354-7	2011	TSPO ligands increase neurosteroidogenesis and are a target of novel anxiolytic drugs producing anxiolytic effects without causing the side effects normally associated with conventional benzodiazepines such as sedation or tolerance.	Benzodiazepines	186-201	translocator protein	Homo sapiens	0-4
21616065-1	2011	The potent sedative-hypnotic zolpidem and the convulsant methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) act primarily by binding to the benzodiazepine site of the main inhibitory neurotransmitter receptor, the pentameric gamma-aminobutyric acid type A receptor (GABA(A)).	Benzodiazepines	154-168	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	280-287
21616065-7	2011	DMCM had an agonistic action through a secondary, low-affinity non-benzodiazepine binding site of the GABA(A) receptor in the forebrain of gamma2I77 mice, and this drug also fully displaced the residual benzodiazepine-site labeling.	Benzodiazepines	67-81	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	102-109
21616065-1	2011	The potent sedative-hypnotic zolpidem and the convulsant methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) act primarily by binding to the benzodiazepine site of the main inhibitory neurotransmitter receptor, the pentameric gamma-aminobutyric acid type A receptor (GABA(A)).	Benzodiazepines	154-168	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	239-278
21616065-7	2011	DMCM had an agonistic action through a secondary, low-affinity non-benzodiazepine binding site of the GABA(A) receptor in the forebrain of gamma2I77 mice, and this drug also fully displaced the residual benzodiazepine-site labeling.	Benzodiazepines	203-217	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	102-109
20981413-9	2011	CONCLUSIONS: These data indicate enhanced postsynaptic glutamate receptor sensitivity and decreased GABAergic inhibition by a benzodiazepine inverse agonist in CA1 hippocampal neurons of anxious mice are produced by deletion of the 5-HT(1A) receptor.	Benzodiazepines	126-140	carbonic anhydrase 1	Mus musculus	160-163
20943351-2	2011	Besides involvement of the benzodiazepine recognition site of GABA(A) receptor in the expression of anxiety-like behaviour, the roles of the beta(2)/beta(3) subunits are not well characterized.	Benzodiazepines	27-41	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	62-69
21430171-2	2011	These amyloid lesions provoke microglial activation, and recent neuroimaging technologies have enabled visualization of this response in living brains using radioligands for the peripheral benzodiazepine receptor also known as the 18 kDa translocator protein (TSPO).	Benzodiazepines	189-203	translocator protein	Mus musculus	238-258
21430171-2	2011	These amyloid lesions provoke microglial activation, and recent neuroimaging technologies have enabled visualization of this response in living brains using radioligands for the peripheral benzodiazepine receptor also known as the 18 kDa translocator protein (TSPO).	Benzodiazepines	189-203	translocator protein	Mus musculus	260-264
21299850-2	2011	The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein), in a rodent leptin-lacking mutant, the obese ob/ob mouse.	Benzodiazepines	187-201	translocator protein	Mus musculus	207-211
21299850-2	2011	The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein), in a rodent leptin-lacking mutant, the obese ob/ob mouse.	Benzodiazepines	187-201	translocator protein	Mus musculus	213-233
21492891-8	2011	Our work showed that adverse effects in epileptics under high doses of AVP was related to the association of the AVP with other antiepileptic in particular carbamazepine, phenobarbital and benzodiazepines rather than supra-therapeutic plasmatic concentrations of AVP.	Benzodiazepines	189-204	arginine vasopressin	Homo sapiens	71-74
21492891-8	2011	Our work showed that adverse effects in epileptics under high doses of AVP was related to the association of the AVP with other antiepileptic in particular carbamazepine, phenobarbital and benzodiazepines rather than supra-therapeutic plasmatic concentrations of AVP.	Benzodiazepines	189-204	arginine vasopressin	Homo sapiens	113-116
21492891-8	2011	Our work showed that adverse effects in epileptics under high doses of AVP was related to the association of the AVP with other antiepileptic in particular carbamazepine, phenobarbital and benzodiazepines rather than supra-therapeutic plasmatic concentrations of AVP.	Benzodiazepines	189-204	arginine vasopressin	Homo sapiens	113-116
21564163-10	2011	CONCLUSIONS: These data demonstrate an inhibitory effect of ALP in the regulation of the ACTH/cortisol response to physical exercise in man and suggest that GABAergic receptor activating benzodiazepines and opioids interact in the neuroendocrine secretion of ACTH/cortisol.	Benzodiazepines	187-202	proopiomelanocortin	Homo sapiens	89-93
21564163-10	2011	CONCLUSIONS: These data demonstrate an inhibitory effect of ALP in the regulation of the ACTH/cortisol response to physical exercise in man and suggest that GABAergic receptor activating benzodiazepines and opioids interact in the neuroendocrine secretion of ACTH/cortisol.	Benzodiazepines	187-202	proopiomelanocortin	Homo sapiens	259-263
21530274-0	2011	New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the gamma-aminobutyric acid type A (GABAA) receptor.	Benzodiazepines	151-165	defensin beta 103B	Homo sapiens	106-111
21530274-1	2011	The pharmacophoric model using ADLR procedure, based on pyrazolo[5,1-c][1,2,4]benzotriazine system, studied in our laboratory, allowed us to identify the essential interaction points (HBp-1, HBp-2, and Lp-1) and the important areas for affinity modulation (HBp-3 and Lp-2) for binding recognition at benzodiazepine (Bzs) site of GABA(A) receptors (GABA(A)-Rs).	Benzodiazepines	300-314	defensin beta 103B	Homo sapiens	257-262
21444611-8	2011	Users of benzodiazepines had a higher risk of death (RR 1.28, 95% CI 1.04-1.58) compared with users of atypical antipsychotics.	Benzodiazepines	9-24	ribonucleotide reductase catalytic subunit M1	Homo sapiens	53-57
20627473-8	2011	These data suggest that D(3)(-/-) mice exhibit low baseline anxiety levels and provide the evidence that the DRD3 is involved in the modulation of benzodiazepine anxiolytic effects.	Benzodiazepines	147-161	dopamine receptor D3	Mus musculus	109-113
21087553-6	2011	These data suggest that selective CRF1 receptor antagonists could be a novel target for developing anti-panic drugs that are as effective as benzodiazepines in acute treatment of a panic attack without the deleterious side-effects (e.g. sedation and cognitive impairment) associated with benzodiazepines.	Benzodiazepines	141-156	corticotropin releasing hormone receptor 1	Rattus norvegicus	34-38
21087553-6	2011	These data suggest that selective CRF1 receptor antagonists could be a novel target for developing anti-panic drugs that are as effective as benzodiazepines in acute treatment of a panic attack without the deleterious side-effects (e.g. sedation and cognitive impairment) associated with benzodiazepines.	Benzodiazepines	288-303	corticotropin releasing hormone receptor 1	Rattus norvegicus	34-38
21262851-5	2011	Allopregnanolone was the most potent inhibitor (IC(50), ~10 muM), followed by BDZs (IC(50), ~50 muM), pentobarbital (IC(50), 0.3-1 mM), and ethanol (IC(50), ~300 mM).	Benzodiazepines	78-82	latexin	Homo sapiens	96-99
20981413-9	2011	CONCLUSIONS: These data indicate enhanced postsynaptic glutamate receptor sensitivity and decreased GABAergic inhibition by a benzodiazepine inverse agonist in CA1 hippocampal neurons of anxious mice are produced by deletion of the 5-HT(1A) receptor.	Benzodiazepines	126-140	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	232-249
20935233-0	2011	Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors: a physiological brake on CA1 neuron alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyperexcitability during benzodiazepine withdrawal.	Benzodiazepines	204-218	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	28-34
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Benzodiazepines	110-124	translocator protein	Homo sapiens	13-33
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Benzodiazepines	110-124	translocator protein	Homo sapiens	35-39
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Benzodiazepines	110-124	translocator protein	Homo sapiens	144-184
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Benzodiazepines	110-124	translocator protein	Homo sapiens	186-189
20498136-1	2011	Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level.	Benzodiazepines	0-14	protein tyrosine kinase 7 (inactive)	Homo sapiens	56-61
21158011-5	2011	A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities.	Benzodiazepines	64-78	opioid receptor mu 1	Homo sapiens	102-107
32272540-1	2011	Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents.	Benzodiazepines	16-30	translocator protein	Rattus norvegicus	41-44
20935233-0	2011	Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors: a physiological brake on CA1 neuron alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyperexcitability during benzodiazepine withdrawal.	Benzodiazepines	204-218	carbonic anhydrase 1	Rattus norvegicus	111-114
20935233-1	2011	A significant link was previously established between benzodiazepine withdrawal anxiety and a progressive increase in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) potentiation in hippocampal CA1 neurons from rats withdrawn up to 2 days from 1-week oral administration of the benzodiazepine flurazepam (FZP).	Benzodiazepines	54-68	carbonic anhydrase 1	Rattus norvegicus	220-223
20935233-1	2011	A significant link was previously established between benzodiazepine withdrawal anxiety and a progressive increase in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) potentiation in hippocampal CA1 neurons from rats withdrawn up to 2 days from 1-week oral administration of the benzodiazepine flurazepam (FZP).	Benzodiazepines	304-318	carbonic anhydrase 1	Rattus norvegicus	220-223
20935233-9	2011	Collectively, these findings suggest that a reduction of GluN2B-containing NMDAR may serve as a homeostatic feedback mechanism to modulate glutamatergic synaptic strength during FZP withdrawal to alleviate benzodiazepine withdrawal symptoms.	Benzodiazepines	206-220	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	57-63
21159950-2	2010	Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing neurosteroids, the role of neurosteroids in the clinical effects of BDZs is unknown.	Benzodiazepines	14-18	translocator protein	Rattus norvegicus	85-89
20385173-7	2010	The effects of mGluR8 positive allosteric modulators, which only affect neurotransmission in the presence of extracellular glutamate, seem particularly promising for patients with anxiety disorders showing benzodiazepine insensitivity.	Benzodiazepines	206-220	glutamate receptor, metabotropic 8	Mus musculus	15-21
20846531-3	2010	However, recent studies showed that BZD also act on peripheral benzodiazepine receptor sites (PBR) or translocator protein 18 kDa (TSPO).	Benzodiazepines	36-39	translocator protein	Rattus norvegicus	94-97
20846531-3	2010	However, recent studies showed that BZD also act on peripheral benzodiazepine receptor sites (PBR) or translocator protein 18 kDa (TSPO).	Benzodiazepines	36-39	translocator protein	Rattus norvegicus	131-135
20853509-0	2010	Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	175-189	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	71-76
20853509-0	2010	Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	175-189	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	78-84
20853509-0	2010	Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	175-189	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	90-96
20853509-0	2010	Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	175-189	carbonic anhydrase 1	Rattus norvegicus	155-158
20853509-1	2010	Benzodiazepine withdrawal-anxiety is associated with enhanced alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)-mediated glutamatergic transmission in rat hippocampal CA1 synapses due to enhanced synaptic insertion and phosphorylation of GluA1 homomers.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	191-194
20853509-1	2010	Benzodiazepine withdrawal-anxiety is associated with enhanced alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)-mediated glutamatergic transmission in rat hippocampal CA1 synapses due to enhanced synaptic insertion and phosphorylation of GluA1 homomers.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	262-267
20621550-0	2010	Binding of several benzodiazepines to bovine serum albumin: Fluorescence study.	Benzodiazepines	19-34	albumin	Homo sapiens	45-58
20923553-14	2010	Nonetheless, based on strong specific associations between certain MAF profiles and specific geometric descriptors we identified, the shapes of the binding sites do have a crucial role in virtual drug design for certain drug categories, including morphine derivatives, benzodiazepines, barbiturates and antihistamines.	Benzodiazepines	269-284	MAF bZIP transcription factor	Homo sapiens	67-70
20621066-0	2010	TNF-alpha induced PMN apoptosis in whole human blood: protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand.	Benzodiazepines	120-134	tumor necrosis factor	Homo sapiens	0-9
20546699-0	2010	Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation.	Benzodiazepines	20-34	opsin 1, short wave sensitive	Homo sapiens	12-15
20668445-7	2010	In these methadone-related deaths, OPRM1 118GA was associated with higher postmortem benzodiazepine concentrations (P = 0.04), a finding not associated with morphine-related deaths.	Benzodiazepines	85-99	opioid receptor mu 1	Homo sapiens	35-40
20546699-2	2010	An exposure-based cognitive-behavioral treatment for BZ discontinuation, Panic Control Treatment for BZ Discontinuation (CBT) targets the fear of these sensations and has demonstrated efficacy in preventing disorder relapse and facilitating successful BZ discontinuation among patients with panic disorder.	Benzodiazepines	53-55	opsin 1, short wave sensitive	Homo sapiens	121-124
20546699-2	2010	An exposure-based cognitive-behavioral treatment for BZ discontinuation, Panic Control Treatment for BZ Discontinuation (CBT) targets the fear of these sensations and has demonstrated efficacy in preventing disorder relapse and facilitating successful BZ discontinuation among patients with panic disorder.	Benzodiazepines	101-103	opsin 1, short wave sensitive	Homo sapiens	121-124
20546699-2	2010	An exposure-based cognitive-behavioral treatment for BZ discontinuation, Panic Control Treatment for BZ Discontinuation (CBT) targets the fear of these sensations and has demonstrated efficacy in preventing disorder relapse and facilitating successful BZ discontinuation among patients with panic disorder.	Benzodiazepines	101-103	opsin 1, short wave sensitive	Homo sapiens	121-124
20546699-4	2010	Based on the primary outcome of successful discontinuation of BZ use, results indicate that adjunctive CBT provided additive benefits above both taper alone and taper plus relaxation, with consistently medium and large effect sizes over time that reached significance at the six month follow-up evaluation.	Benzodiazepines	62-64	opsin 1, short wave sensitive	Homo sapiens	103-106
20546699-6	2010	These findings suggest that CBT provides specific efficacy for the successful discontinuation from BZs, even when controlling for therapist contact and relaxation training.	Benzodiazepines	99-102	opsin 1, short wave sensitive	Homo sapiens	28-31
20445501-1	2010	Benzodiazepine withdrawal anxiety is associated with potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal neurons attributable to increased synaptic incorporation of GluA1-containing AMPARs.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	163-166
20445501-1	2010	Benzodiazepine withdrawal anxiety is associated with potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal neurons attributable to increased synaptic incorporation of GluA1-containing AMPARs.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	237-242
20445501-10	2010	Synaptic insertion and subsequent CaMKII alpha-mediated Ser(831) phosphorylation of GluA1 homomers contribute to benzodiazepine withdrawal-induced AMPAR potentiation and may represent an important hippocampal pathway mediating both drug-induced and activity-dependent plasticity.	Benzodiazepines	113-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
20445501-1	2010	Benzodiazepine withdrawal anxiety is associated with potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal neurons attributable to increased synaptic incorporation of GluA1-containing AMPARs.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	254-260
20223640-6	2010	Moreover, pre-treatment with midazolam, a benzodiazepine ligand, not only prevented the excessive anxiety but also attenuated the p35 increase in the BLA of stressed rats.	Benzodiazepines	42-56	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	130-133
20417252-0	2010	Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding.	Benzodiazepines	91-105	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	42-65
20417252-5	2010	The gamma2 subunit is essential for the formation of the binding site for benzodiazepines, allosteric modulators of GABA(A) receptors that are clinically often used as sedatives/hypnotics and anxiolytics.	Benzodiazepines	74-89	tryptophanyl-tRNA synthetase 1	Homo sapiens	4-10
20417252-9	2010	Our data suggest a species difference in the expression profiles of the alpha1 and gamma2 subunits in the locus coeruleus, with the sedation-related benzodiazepine sites being more important in man than rodents.	Benzodiazepines	149-163	adrenoceptor alpha 1D	Homo sapiens	72-89
20370325-8	2010	We describe the involvement of the 18-kDa translocator protein (TSPO; previously called peripheral benzodiazepine receptor), and of two new mitochondrial proteins, that is, 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) and p42(IP4) (also designated centaurin alpha1; ADAP 1), in the control of the PTP.	Benzodiazepines	99-113	translocator protein	Homo sapiens	64-68
20144901-1	2010	YF476 is a potent and highly selective cholecystokin 2 (CCK(2)) receptor antagonist of the benzodiazepine class.	Benzodiazepines	91-105	cholecystokinin B receptor	Homo sapiens	56-72
19825899-0	2010	The cannabinoid CB1 receptor is involved in the anxiolytic, sedative and amnesic actions of benzodiazepines.	Benzodiazepines	92-107	cannabinoid receptor 1	Homo sapiens	16-19
20485450-6	2010	The affected amino acid was located at residue 40 of the mature GABRG2 protein, which was near the first one of two high-affinity benzodiazepine-binding domains of the gamma2 subunit (Lys-41-Trp-82).	Benzodiazepines	130-144	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	64-70
20565516-7	2010	Current benzodiazepine use was, however, associated with a greater likelihood of concurrent heroin use (OR 2.77), crime (OR 2.04), poorer psychological health (beta = -4.47) and poorer physical health (beta = -2.33).	Benzodiazepines	8-22	tubulin beta 3 class III	Homo sapiens	160-169
20565516-7	2010	Current benzodiazepine use was, however, associated with a greater likelihood of concurrent heroin use (OR 2.77), crime (OR 2.04), poorer psychological health (beta = -4.47) and poorer physical health (beta = -2.33).	Benzodiazepines	8-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	202-211
20428767-6	2010	The mitochondrial Na+/Ca2+ exchanger was blocked by benzodiazepine, CGP37157 (CGP) leading to increased mitochondrial calcium and enhancing the apoptotic effects of TRAIL, TNFalpha related apoptosis inducing ligand.	Benzodiazepines	52-66	solute carrier family 8 member A1	Homo sapiens	18-36
20428767-6	2010	The mitochondrial Na+/Ca2+ exchanger was blocked by benzodiazepine, CGP37157 (CGP) leading to increased mitochondrial calcium and enhancing the apoptotic effects of TRAIL, TNFalpha related apoptosis inducing ligand.	Benzodiazepines	52-66	TNF superfamily member 10	Homo sapiens	165-170
20428767-6	2010	The mitochondrial Na+/Ca2+ exchanger was blocked by benzodiazepine, CGP37157 (CGP) leading to increased mitochondrial calcium and enhancing the apoptotic effects of TRAIL, TNFalpha related apoptosis inducing ligand.	Benzodiazepines	52-66	tumor necrosis factor	Homo sapiens	172-180
20163925-3	2010	There was no significant change in the proportion of alcohol positive cases, but the proportion of benzodiazepine positive cases increased across time (OR 1.11), as did methadone positive cases (OR 1.12).	Benzodiazepines	99-113	olfactory receptor family 7 subfamily E member 10 pseudogene	Homo sapiens	152-159
19825899-2	2010	These results suggest that the pharmacological effects of benzodiazepines may involve the participation of cannabinoid CB1 receptors.	Benzodiazepines	58-73	cannabinoid receptor 1	Homo sapiens	119-122
19825899-9	2010	Furthermore, these results suggest that blockade of cannabinoid CB1 receptors may be useful in the treatment of patients with problems related to the consumption of benzodiazepines.	Benzodiazepines	165-180	cannabinoid receptor 1	Homo sapiens	64-67
20467592-7	2010	Thus, presently available evidence tends to indicate that the association of a 5-HT(2A) receptor antagonist or a 5-HT(2A) receptor inverse agonist with a BZD or a non-BZD hypnotic could be a valid alternative to normalize SWS in patients with primary or comorbid insomnia.	Benzodiazepines	154-157	5-hydroxytryptamine receptor 2A	Homo sapiens	79-96
20140603-0	2010	BDNF plasma levels decrease during benzodiazepine withdrawal in patients suffering from comorbidity of depressive disorder and benzodiazepine dependence.	Benzodiazepines	35-49	brain derived neurotrophic factor	Homo sapiens	0-4
20140603-0	2010	BDNF plasma levels decrease during benzodiazepine withdrawal in patients suffering from comorbidity of depressive disorder and benzodiazepine dependence.	Benzodiazepines	127-141	brain derived neurotrophic factor	Homo sapiens	0-4
20080160-0	2010	Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.	Benzodiazepines	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105
20144545-4	2010	Based on the X-ray structure of VDR and an LXXLL-containing peptide fragment of the coactivator (where L is leucine and X is any amino acid), which adopts a partially alpha-helical conformation, benzodiazepine molecules were rationally designed as non-peptide coactivator mimetics.	Benzodiazepines	195-209	vitamin D receptor	Homo sapiens	32-35
20299026-2	2010	In particular, 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([BMIM][NTf2]) was the best IL additive for the separation system because its anionic moiety interacted favorably with the benzodiazepines.	Benzodiazepines	201-216	nuclear transport factor 2	Homo sapiens	86-90
20299026-5	2010	The optimal BGE, containing 170 mM [BMIM][NTf2] and 10 mM SDS, provided baseline separation, high efficiency, and satisfactory peak shapes for the benzodiazepines.	Benzodiazepines	147-162	nuclear transport factor 2	Homo sapiens	42-46
20299026-9	2010	Our experimental results reveal that the combination of [BMIM][NTf2] and SDS provides adequate separation efficiency for its application to CE analyses of benzodiazepines after SPE concentration.	Benzodiazepines	155-170	nuclear transport factor 2	Homo sapiens	63-67
20080160-0	2010	Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.	Benzodiazepines	0-15	nuclear receptor subfamily 1 group I member 2	Homo sapiens	58-77
19719748-2	2010	Midazolam, a short-acting benzodiazepine, has been considered a probe for estimating hepatic and intestinal cytochrome P450 (CYP) 3A activity in humans.	Benzodiazepines	26-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-132
20467592-7	2010	Thus, presently available evidence tends to indicate that the association of a 5-HT(2A) receptor antagonist or a 5-HT(2A) receptor inverse agonist with a BZD or a non-BZD hypnotic could be a valid alternative to normalize SWS in patients with primary or comorbid insomnia.	Benzodiazepines	154-157	5-hydroxytryptamine receptor 2A	Homo sapiens	113-130
20467592-7	2010	Thus, presently available evidence tends to indicate that the association of a 5-HT(2A) receptor antagonist or a 5-HT(2A) receptor inverse agonist with a BZD or a non-BZD hypnotic could be a valid alternative to normalize SWS in patients with primary or comorbid insomnia.	Benzodiazepines	167-170	5-hydroxytryptamine receptor 2A	Homo sapiens	113-130
19699782-0	2009	The anterior cingulate cortex is a target structure for the anxiolytic-like effects of benzodiazepines assessed by repeated exposure to the elevated plus maze and Fos immunoreactivity.	Benzodiazepines	87-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	163-166
19811773-5	2010	RESULTS: Pharmacologic 5-HT(1A) receptor blockade during the early postnatal period induced long-lasting effects on anxiety and benzodiazepine sensitivity in adolescent and adult mice on a Swiss-Webster background and resembles the SW 1AKO phenotype.	Benzodiazepines	128-142	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	23-40
19909275-2	2009	In the brain, most of the benzodiazepine-sensitive synaptic receptor subtypes are assembled from alpha(1-3), beta(1-3) and gamma(2) subunits.	Benzodiazepines	26-40	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	109-117
19909283-2	2009	BZ-induced potentiation of GABA(A)R (gamma-aminobutyric acid type-A receptor) function by 1-week oral administration of FZP (flurazepam) bi-directionally modulates excitatory glutamatergic synaptic transmission in hippocampal CA1 neurons during drug withdrawal.	Benzodiazepines	0-2	carbonic anhydrase 1	Rattus norvegicus	226-229
19914403-2	2010	In the present study, we revealed that diazepam, a mixed-type benzodiazepine, inhibited IFN-gamma production by human peripheral blood mononuclear cells (PBMCs) induced by anti-CD3 in dose-dependent manner.	Benzodiazepines	62-76	interferon gamma	Homo sapiens	88-97
19941877-6	2010	We tested their sensitivity to gabazine and two drugs acting at the benzodiazepine site of alpha1/alpha2/alpha3 or alpha5GABA(A)Rs (400 nM zolpidem and 20 nM L-655,708, respectively).	Benzodiazepines	68-82	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	91-111
20007010-5	2010	Despite the decrease in KCC2 expression, spinal administration of benzodiazepines has been shown to be anti-allodynic in neuropathic conditions.	Benzodiazepines	66-81	solute carrier family 12 member 5	Homo sapiens	24-28
21309116-1	2010	Nonselective benzodiazepines exert their pharmacological effects via GABAA receptors containing either an alpha1, alpha2, alpha3, or alpha5 subunit.	Benzodiazepines	13-28	adrenoceptor alpha 1D	Homo sapiens	106-112
20224918-0	2009	The actions of chloride channel blockers, barbiturates and a benzodiazepine on Caenorhabditis elegans glutamate- and ivermectin-gated chloride channel subunits expressed in Xenopus oocytes.	Benzodiazepines	61-75	Ig-like domain-containing protein	Caenorhabditis elegans	102-150
19699782-9	2009	Fos immunohistochemistry showed that midazolam injections were associated with a distinct pattern of action when administered before the test or retest session, and the anterior cingulate cortex, area 1 (Cg1), was the only structure targeted by the benzodiazepine in both situations.	Benzodiazepines	249-263	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
19497344-1	2009	AC-5216, a ligand for the translocator protein (18 kDa) (TSPO), produces anxiolytic-like effects in animal models of anxiety without causing the side effects normally associated with conventional benzodiazepines.	Benzodiazepines	196-211	translocator protein	Mus musculus	26-46
19903874-2	2009	While the pharmacological manipulation of GABA(A)R function by therapeutic agents, such as benzodiazepines can have profound effects on neuronal excitation and behavior, the endogenous mechanisms neurons use to regulate the efficacy of synaptic inhibition and their impact on behavior remains poorly understood.	Benzodiazepines	91-106	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	42-50
19639308-6	2009	Analysis of 61 patients using only CYP3A4 metabolised benzodiazepines showed this class to be associated with higher (R)-concentration/dose, which is consistent with a potential competitive inhibition of CYP3A4.	Benzodiazepines	54-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	35-41
19639308-6	2009	Analysis of 61 patients using only CYP3A4 metabolised benzodiazepines showed this class to be associated with higher (R)-concentration/dose, which is consistent with a potential competitive inhibition of CYP3A4.	Benzodiazepines	54-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	204-210
19747934-7	2009	Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system.	Benzodiazepines	167-181	aldehyde dehydrogenase 2 family member	Rattus norvegicus	45-51
19789311-3	2009	The goal of our study was to examine the expression and biological relevance of TSPO in prostate cancer and show that the commonly prescribed benzodiazepine lorazepam, a ligand for TSPO, exhibits anticancer properties.	Benzodiazepines	142-156	translocator protein	Homo sapiens	80-84
19789311-3	2009	The goal of our study was to examine the expression and biological relevance of TSPO in prostate cancer and show that the commonly prescribed benzodiazepine lorazepam, a ligand for TSPO, exhibits anticancer properties.	Benzodiazepines	142-156	translocator protein	Homo sapiens	181-185
19789311-10	2009	CONCLUSION: These data suggest that blocking TSPO function in tumor cells induces cell death and denotes a survival role for TSPO in prostate cancer and provides the first evidence for the use of benzodiazepines in prostate cancer therapeutics.	Benzodiazepines	196-211	translocator protein	Homo sapiens	45-49
19789311-10	2009	CONCLUSION: These data suggest that blocking TSPO function in tumor cells induces cell death and denotes a survival role for TSPO in prostate cancer and provides the first evidence for the use of benzodiazepines in prostate cancer therapeutics.	Benzodiazepines	196-211	translocator protein	Homo sapiens	125-129
19409385-4	2009	Translocator protein (TSPO) is an 18-kDa outer mitochondrial membrane protein that interacts with the mitochondria permeability transition pore and binds with high affinity to cholesterol and various classes of drug ligands, including some benzodiazepines such as 4"-chlorodiazepam (Ro5-4864).	Benzodiazepines	240-255	translocator protein	Homo sapiens	0-20
19409385-4	2009	Translocator protein (TSPO) is an 18-kDa outer mitochondrial membrane protein that interacts with the mitochondria permeability transition pore and binds with high affinity to cholesterol and various classes of drug ligands, including some benzodiazepines such as 4"-chlorodiazepam (Ro5-4864).	Benzodiazepines	240-255	translocator protein	Homo sapiens	22-26
19497344-1	2009	AC-5216, a ligand for the translocator protein (18 kDa) (TSPO), produces anxiolytic-like effects in animal models of anxiety without causing the side effects normally associated with conventional benzodiazepines.	Benzodiazepines	196-211	translocator protein	Mus musculus	57-61
19420124-5	2009	Typical of several drug classes and two cell types, in CA1 pyramidal neurons, the benzodiazepine diazepam doubled the total charge transfer (TCT) of miniature postsynaptic inhibitory currents (mIPSCs), whereas it quadrupled the TCT of tonic currents.	Benzodiazepines	82-96	carbonic anhydrase 1	Rattus norvegicus	55-58
19392661-7	2009	Specifically, benzodiazepine Ro5-4864 and protoporphyrin IX showed 5-13-fold lower affinity for duodenal TSPO.	Benzodiazepines	14-28	translocator protein	Rattus norvegicus	105-109
19358834-2	2009	Since benzodiazepines are commonly used to treat muscle spasticity in spinal cord injured subjects and the gamma2 subunit of the GABA(A) receptor is necessary for benzodiazepine binding, this subunit may be an important factor modulating sensorimotor function after an injury.	Benzodiazepines	6-21	crystallin, gamma E	Rattus norvegicus	107-113
19406876-8	2009	Application of benzodiazepines, which rescues OD plasticity, also increases NR2A levels.	Benzodiazepines	15-30	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	76-80
19358834-2	2009	Since benzodiazepines are commonly used to treat muscle spasticity in spinal cord injured subjects and the gamma2 subunit of the GABA(A) receptor is necessary for benzodiazepine binding, this subunit may be an important factor modulating sensorimotor function after an injury.	Benzodiazepines	6-20	crystallin, gamma E	Rattus norvegicus	107-113
19077109-2	2009	For example, positron emission tomography imaging employing radioligands for the mitochondrial translocator protein of 18 kDa (TSPO, formerly known as the peripheral benzodiazepine receptor) is being scrutinized to detect neuroinflammation in various diseases.	Benzodiazepines	166-180	translocator protein	Homo sapiens	127-131
19101875-6	2009	Also alterations in the expression of neuropeptides like Corticotropin Releasing Hormone and Neuropeptide Y are thought to be involved in the development of benzodiazepine dependence.	Benzodiazepines	157-171	corticotropin releasing hormone	Homo sapiens	57-88
19285093-3	2009	Increased expression of alpha4-containing GABAR was verified by a relative insensitivity of GABA (EC(20))-gated current to modulation by the benzodiazepine (BZ) lorazepam (0.01-100 microM), and potentiation of current by flumazenil and RO15-4513, characteristic of alpha4betagamma2 pharmacology.	Benzodiazepines	141-155	immunoglobulin binding protein 1	Homo sapiens	24-30
19285093-3	2009	Increased expression of alpha4-containing GABAR was verified by a relative insensitivity of GABA (EC(20))-gated current to modulation by the benzodiazepine (BZ) lorazepam (0.01-100 microM), and potentiation of current by flumazenil and RO15-4513, characteristic of alpha4betagamma2 pharmacology.	Benzodiazepines	157-159	immunoglobulin binding protein 1	Homo sapiens	24-30
19285093-4	2009	In contrast to THP, compounds which decrease GABA-gated current, such as the BZ inverse agonist DMCM, the GABAR antagonist gabazine and the open channel blocker penicillin, decreased alpha4 expression after a 48 h exposure, without changing BZ responsiveness.	Benzodiazepines	77-79	immunoglobulin binding protein 1	Homo sapiens	183-189
19400959-1	2009	BACKGROUND: Laboratory tests for routine drug of abuse and toxicology (DOA/Tox) screening, often used in emergency medicine, generally utilize antibody-based tests (immunoassays) to detect classes of drugs such as amphetamines, barbiturates, benzodiazepines, opiates, and tricyclic antidepressants, or individual drugs such as cocaine, methadone, and phencyclidine.	Benzodiazepines	242-257	thymocyte selection associated high mobility group box	Homo sapiens	75-78
19299782-0	2009	The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.	Benzodiazepines	15-30	urotensin 2	Rattus norvegicus	34-46
19299782-3	2009	We hypothesized that there was some interaction between benzodiazepines and the UII system in the cerebral cortex.	Benzodiazepines	56-71	urotensin 2	Rattus norvegicus	80-83
19299782-4	2009	METHODS: In the present study, we have examined the effects of benzodiazepines on UII-increased norepinephrine release from rat cerebrocortical slices and intracellular Ca(2+) concentrations ([Ca(2+)]i) in HEK293 cells expressing rat UT receptor (HEK293-rUT cells).	Benzodiazepines	63-78	urotensin 2	Rattus norvegicus	82-85
19299782-7	2009	The inhibitory effects of midazolam on UII-evoked norepinephrine release were significantly attenuated by flumazenil, a benzodiazepine site antagonist.	Benzodiazepines	120-134	urotensin 2	Rattus norvegicus	39-42
18810397-7	2009	The strongest predictors for being prescribed benzodiazepines were previous use of anxiolytics [odds ratio (OR) 1.8, 95% confidence interval (CI) 1.7-2.0] and male gender (OR 1.5, 95% CI 1.4-1.6).	Benzodiazepines	46-61	olfactory receptor family 10 subfamily R member 2	Homo sapiens	96-115
19302901-2	2009	Midazolam, a short-acting benzodiazepine, is metabolized by CYP3A4.	Benzodiazepines	26-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66
19302901-22	2009	Monitoring patients for adverse events, the need for dose adjustments, or both during coadministration with posaconazole may be warranted in patients being treated with benzodiazepines that are predominantly metabolized through CYP3A4 (eg, midazolam).	Benzodiazepines	169-184	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	228-234
19091469-12	2009	), an "anxioselective" benzodiazepine site agonist with preferential activity at alpha2/alpha3 subunits, significantly reduced formalin-induced flinching in wild-type mice.	Benzodiazepines	23-37	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	81-94
19368851-3	2009	Because benzodiazepines and ethanol have similar effect signatures, it has been hypothesized that these drugs share the gamma2-containing GABA(A) receptors as a mechanism of action.	Benzodiazepines	8-23	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	120-126
19514515-7	2009	Four categories of medications, namely, dopaminergic agents, opioids, anticonvulsants, and benzodiazepines were identified as frequently prescribed drugs for RLS.	Benzodiazepines	91-106	RLS1	Homo sapiens	158-161
19514515-12	2009	Benzodiazepines, including clonazepam and nitrazepam, are widely prescribed, but their therapeutic effects on RLS symptoms were rather modest.	Benzodiazepines	0-15	RLS1	Homo sapiens	110-113
19514515-13	2009	Therefore, benzodiazepines are mostly used to improve the sleep quality in patients with RLS.	Benzodiazepines	11-26	RLS1	Homo sapiens	89-92
19371318-1	2009	AIMS: Midazolam (MDZ) is a benzodiazepine used as a CYP3A4 probe in clinical and in vitro studies.	Benzodiazepines	27-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-58
19159673-8	2009	Finally, pre-treatment with the benzodiazepine anxiolytic chlordiazepoxide prevented the stress-induced increase in IL-10 and IL-19 expression.	Benzodiazepines	32-46	interleukin 10	Mus musculus	116-121
19159673-8	2009	Finally, pre-treatment with the benzodiazepine anxiolytic chlordiazepoxide prevented the stress-induced increase in IL-10 and IL-19 expression.	Benzodiazepines	32-46	interleukin 19	Mus musculus	126-131
19317385-6	2009	In one report, low-dose benzodiazepines and ropinirole were associated with resolution of RLS symptoms stating dopamine depletion as the likely etiology.	Benzodiazepines	24-39	RLS1	Homo sapiens	90-93
19317385-7	2009	In our patient, however, RLS due to olanzapine was refractory to the trial of both high-dose benzodiazepine and ropinirole.	Benzodiazepines	93-107	RLS1	Homo sapiens	25-28
19005028-0	2009	Metabolic activation of benzodiazepines by CYP3A4.	Benzodiazepines	24-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49
19005028-4	2009	To clarify whether benzodiazepines are metabolically activated, 14 benzodiazepines were investigated for their cytotoxic effects on HepG2 cells treated with recombinant CYP3A4.	Benzodiazepines	67-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-175
19005028-6	2009	In contrast, in the case of other benzodiazepines, the changes in the cell viability between CYP3A4 and control Supersomes were less than 10%.	Benzodiazepines	34-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
19005028-10	2009	Therefore, the presence of a nitro group in the side chain of benzodiazepines may play a crucial role in the metabolic activation by CYP3A4.	Benzodiazepines	62-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
19101875-6	2009	Also alterations in the expression of neuropeptides like Corticotropin Releasing Hormone and Neuropeptide Y are thought to be involved in the development of benzodiazepine dependence.	Benzodiazepines	157-171	neuropeptide Y	Homo sapiens	93-107
18812492-0	2008	Chronic benzodiazepine administration potentiates high voltage-activated calcium currents in hippocampal CA1 neurons.	Benzodiazepines	8-22	carbonic anhydrase 1	Homo sapiens	105-108
18924138-0	2008	Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	91-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	24-29
18924138-0	2008	Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	91-105	carbonic anhydrase 1	Rattus norvegicus	71-74
18924138-8	2008	Taken together with recent functional data from our laboratory, the current study suggests that the enhanced glutamatergic strength at CA1 neuron synapses during benzodiazepine withdrawal is mediated by increased incorporation of GluR1-containing AMPARs.	Benzodiazepines	162-176	carbonic anhydrase 1	Rattus norvegicus	135-138
18924138-8	2008	Taken together with recent functional data from our laboratory, the current study suggests that the enhanced glutamatergic strength at CA1 neuron synapses during benzodiazepine withdrawal is mediated by increased incorporation of GluR1-containing AMPARs.	Benzodiazepines	162-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
18924138-8	2008	Taken together with recent functional data from our laboratory, the current study suggests that the enhanced glutamatergic strength at CA1 neuron synapses during benzodiazepine withdrawal is mediated by increased incorporation of GluR1-containing AMPARs.	Benzodiazepines	162-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	247-253
18940236-6	2008	This neurophysiological signature, common to all classes of anxiolytic drugs (i.e. benzodiazepines, selective 5-HT reuptake inhibitors, 5-HT1A agonists) provides strong converging evidence for the anxiolytic-like characteristics of SST.	Benzodiazepines	83-98	somatostatin	Rattus norvegicus	232-235
19548867-5	2009	Unlike benzodiazepines (Bzs), which represent the most common anti-anxiety drugs administered around the world, selective TSPO ligands have shown anxiolytic effects in animal models without any of the side effects associated with Bzs.	Benzodiazepines	230-233	translocator protein	Homo sapiens	122-126
18563060-8	2009	A single injection of the GABA(A) receptor alpha1 subunit-preferring benzodiazepine-site ligand zolpidem also produced an increase in the AMPA/NMDA ratio in VTA dopamine neurons.	Benzodiazepines	69-83	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	26-49
19005054-4	2008	However, their response to flunitrazepam was not altered, suggesting that PKCdelta regulates benzodiazepine-insensitive GABA(A) receptors, most of which contain delta subunits and mediate tonic inhibitory currents in neurons.	Benzodiazepines	93-107	protein kinase C, delta	Mus musculus	74-82
18805463-0	2008	Chronic benzodiazepine-induced reduction in GABA(A) receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection.	Benzodiazepines	8-22	carbonic anhydrase 1	Rattus norvegicus	103-106
18805463-1	2008	One week oral flurazepam (FZP) administration in rats results in reduced GABA(A) receptor-mediated synaptic transmission in CA1 pyramidal neurons associated with benzodiazepine tolerance in vivo and in vitro.	Benzodiazepines	162-176	carbonic anhydrase 1	Rattus norvegicus	124-127
18805463-2	2008	Since voltage-gated calcium channel (VGCC) current density is enhanced twofold during chronic FZP treatment, the role of L-type VGCCs in regulating benzodiazepine-induced changes in CA1 neuron GABA(A) receptor-mediated function was evaluated.	Benzodiazepines	148-162	carbonic anhydrase 1	Rattus norvegicus	182-185
18698836-1	2008	A conjugable analogue of the benzodiazepine 5-(2-hydroxiphenyl)-7-nitro-benzo[ e][1,4]diazepin-2(3 H)-one N 1-substituted with an aliphatic chain (CNZ acyl derivative, CAd) was synthesized.	Benzodiazepines	29-43	aconitate decarboxylase 1	Homo sapiens	168-171
18216773-1	2008	Amygdala opioids such as enkephalin appear to play some role in the control of anxiety and the anxiolytic effects of benzodiazepines, although the opioid receptor subtypes mediating such effects are unclear.	Benzodiazepines	117-132	proenkephalin	Rattus norvegicus	25-35
18657554-1	2008	Recent genetic and pharmacological studies have demonstrated that alpha(2)-containing GABA(A) receptors mediate the anxiolytic effects of benzodiazepines, setting a new strategy in developing novel, non-sedative anxiolytic agents.	Benzodiazepines	138-153	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	66-71
18621527-2	2008	The molecular basis of CCK-receptor binding has been debated, with one prominent model suggesting occupation of the same region of the intramembranous helical bundle as benzodiazepines.	Benzodiazepines	169-184	cholecystokinin	Homo sapiens	23-26
18586237-10	2008	These findings suggest that the anxiolytic-like effects of N/OFQ may be related to the GABA/benzodiazepine system in the amygdala.	Benzodiazepines	92-106	prepronociceptin	Mus musculus	59-64
18621527-6	2008	Application of an allosteric model to the equilibrium interaction between a series of benzodiazepine ligands and CCK yielded quantitative estimates of each modulator"s affinity for the allosteric site, as well as the degree of negative cooperativity for the interaction between occupied orthosteric and allosteric sites.	Benzodiazepines	86-100	cholecystokinin	Homo sapiens	113-116
18621527-7	2008	The allosteric nature of benzodiazepine binding to the CCK(1) receptor provides new opportunities for small molecule drug development.	Benzodiazepines	25-39	cholecystokinin	Homo sapiens	55-58
18499303-16	2008	In addition, the effects on anxiety of N/OFQ, but not nocistatin, appear to be dependent on the benzodiazepine site of the GABA(A) receptor.	Benzodiazepines	96-110	prepronociceptin	Mus musculus	39-44
18499303-16	2008	In addition, the effects on anxiety of N/OFQ, but not nocistatin, appear to be dependent on the benzodiazepine site of the GABA(A) receptor.	Benzodiazepines	96-110	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	123-130
18190907-3	2008	The aim of this study was to examine the effects of some benzodiazepines (bromazepam, chlordiazepoxide, diazepam and flurazepam) able to bind to P-glycoprotein in proteoliposomes on its transport function and ATPase activity in the human cancer cell line, KB-V1.	Benzodiazepines	57-72	ATP binding cassette subfamily B member 1	Homo sapiens	145-159
18313124-0	2008	Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates.	Benzodiazepines	180-195	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	Mus musculus	25-31
18709269-1	2008	UNLABELLED: This study aimed to identify variables associated to the consumption of benzodiazepine among workers of a private company in the VIII Region, Chile.	Benzodiazepines	84-98	cytochrome c oxidase subunit 8A	Homo sapiens	141-145
18581012-0	2008	Employing mirtazapine to aid benzodiazepine withdrawal.	Benzodiazepines	29-43	activation induced cytidine deaminase	Homo sapiens	25-28
18581012-3	2008	This case describes the use of mirtazapine as an aid in benzodiazepine withdrawal and its potential benefits in alleviating insomnia and depression in a 32-year-old man.	Benzodiazepines	56-70	activation induced cytidine deaminase	Homo sapiens	49-52
18330770-7	2008	The most frequently prescribed medications were second-generation antipsychotics for regular use along with benzodiazepine for PRN use.	Benzodiazepines	108-122	cytosolic iron-sulfur assembly component 3	Homo sapiens	127-130
18088080-1	2008	Benzodiazepines are known to modulate the activity of the hypothalamo-pituitary-adrenocortical (HPA) axis by antagonizing the effects of corticotropin-releasing factor (CRH).	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	137-167
18088080-1	2008	Benzodiazepines are known to modulate the activity of the hypothalamo-pituitary-adrenocortical (HPA) axis by antagonizing the effects of corticotropin-releasing factor (CRH).	Benzodiazepines	0-15	corticotropin releasing hormone	Homo sapiens	169-172
18088080-4	2008	Benzodiazepine treatment interferes not only with the release of CRH but also with the release of NPY and CCK.	Benzodiazepines	0-14	corticotropin releasing hormone	Homo sapiens	65-68
18088080-4	2008	Benzodiazepine treatment interferes not only with the release of CRH but also with the release of NPY and CCK.	Benzodiazepines	0-14	neuropeptide Y	Homo sapiens	98-101
18088080-4	2008	Benzodiazepine treatment interferes not only with the release of CRH but also with the release of NPY and CCK.	Benzodiazepines	0-14	cholecystokinin	Homo sapiens	106-109
18088080-7	2008	Depending on the available results possible implications of NPY and CCK on benzodiazepine addiction and withdrawal symptoms are reviewed, thereby providing topics for further research.	Benzodiazepines	75-89	neuropeptide Y	Homo sapiens	60-63
18088080-7	2008	Depending on the available results possible implications of NPY and CCK on benzodiazepine addiction and withdrawal symptoms are reviewed, thereby providing topics for further research.	Benzodiazepines	75-89	cholecystokinin	Homo sapiens	68-71
18340561-3	2008	In the current study, the metabolite kinetics of a series of CYP3A4 substrates (benzodiazepines) in fresh human hepatocytes from five donors, via a major UK supplier, were investigated and compared with those previously reported (by the authors" laboratory) for cryopreserved human hepatocytes and hepatic microsomes.	Benzodiazepines	80-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67
18578363-7	2008	After adjustment for sex, age, change of weight, alcohol consumption, and smoking status, annual percentage change in BMD decreased by 0.61% among individuals taking angiotensin converting enzyme (ACE) inhibitors continuously in comparison with individuals who had not taken them (p = 0.002): also decreased 0.40% among individuals taking benzodiazepines (BZDs) continuously (p = 0.034).	Benzodiazepines	339-354	angiotensin I converting enzyme	Homo sapiens	166-195
18578363-7	2008	After adjustment for sex, age, change of weight, alcohol consumption, and smoking status, annual percentage change in BMD decreased by 0.61% among individuals taking angiotensin converting enzyme (ACE) inhibitors continuously in comparison with individuals who had not taken them (p = 0.002): also decreased 0.40% among individuals taking benzodiazepines (BZDs) continuously (p = 0.034).	Benzodiazepines	339-354	angiotensin I converting enzyme	Homo sapiens	197-200
18578363-7	2008	After adjustment for sex, age, change of weight, alcohol consumption, and smoking status, annual percentage change in BMD decreased by 0.61% among individuals taking angiotensin converting enzyme (ACE) inhibitors continuously in comparison with individuals who had not taken them (p = 0.002): also decreased 0.40% among individuals taking benzodiazepines (BZDs) continuously (p = 0.034).	Benzodiazepines	356-360	angiotensin I converting enzyme	Homo sapiens	166-195
18578363-7	2008	After adjustment for sex, age, change of weight, alcohol consumption, and smoking status, annual percentage change in BMD decreased by 0.61% among individuals taking angiotensin converting enzyme (ACE) inhibitors continuously in comparison with individuals who had not taken them (p = 0.002): also decreased 0.40% among individuals taking benzodiazepines (BZDs) continuously (p = 0.034).	Benzodiazepines	356-360	angiotensin I converting enzyme	Homo sapiens	197-200
18190907-3	2008	The aim of this study was to examine the effects of some benzodiazepines (bromazepam, chlordiazepoxide, diazepam and flurazepam) able to bind to P-glycoprotein in proteoliposomes on its transport function and ATPase activity in the human cancer cell line, KB-V1.	Benzodiazepines	57-72	dynein axonemal heavy chain 8	Homo sapiens	209-215
18212144-0	2008	S100B protein in benzodiazepine overdose.	Benzodiazepines	17-31	S100 calcium binding protein B	Homo sapiens	0-5
18256255-1	2008	Classical benzodiazepine sensitive GABA(A) receptor subtypes, the major mediators of fast synaptic inhibition in the brain are heteropentamers that can be assembled from alpha1-3/5, beta1-3, and gamma2 subunits, but how neurons orchestrate their selective accumulation at synapses remains obscure.	Benzodiazepines	10-24	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	182-189
18212144-2	2008	The aim of this study was to assess the possible role of S100B, a structural protein of astroglial cells, as a biochemical marker of brain injury in acute benzodiazepine overdose.	Benzodiazepines	155-169	S100 calcium binding protein B	Homo sapiens	57-62
18212144-3	2008	METHODS: Serum S100B determination was performed in 38 consecutive patients admitted to the emergency department (ED) in Ljubljana with benzodiazepine overdose.	Benzodiazepines	136-150	S100 calcium binding protein B	Homo sapiens	15-20
18212144-7	2008	RESULTS: There were significant differences in S100B levels between the control group and the patients with benzodiazepine overdose according to their responsiveness to a verbal stimulus.	Benzodiazepines	108-122	S100 calcium binding protein B	Homo sapiens	47-52
18212144-8	2008	Post hoc test results showed that S100B levels in patients with benzodiazepine overdose who were unresponsive to a verbal stimulus were significantly higher than those in patients responsive to a verbal stimulus (median 0.31 vs 0.11 microg/l; p = 0.001).	Benzodiazepines	64-78	S100 calcium binding protein B	Homo sapiens	34-39
18212144-9	2008	Both groups of patients with benzodiazepine overdose had significantly higher S100B levels than the control group (median 0.07 microg/; both p = 0.001).	Benzodiazepines	29-43	S100 calcium binding protein B	Homo sapiens	78-83
18212144-12	2008	CONCLUSION: Raised levels of S100B protein are associated with depressed levels of consciousness and respiratory insufficiency in patients with benzodiazepine overdose.	Benzodiazepines	144-158	S100 calcium binding protein B	Homo sapiens	29-34
17875639-0	2007	Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.	Benzodiazepines	98-113	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	141-147
18333964-1	2008	The translocator protein (18 kDa; TSPO), formerly known as the peripheral benzodiazepine receptor, is an outer mitochondrial membrane protein that associates with the mitochondrial permeability transition pore to regulate both steroidogenesis and apoptosis.	Benzodiazepines	74-88	translocator protein	Rattus norvegicus	34-38
17974564-0	2008	The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation.	Benzodiazepines	64-78	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	18-40
17953656-6	2007	The homologous residues to alpha(5) H105 in alpha(1) , alpha(2) , and alpha(3) are well-known determinants of the action of classical benzodiazepines.	Benzodiazepines	134-149	immunoglobulin binding protein 1	Homo sapiens	27-32
17953656-6	2007	The homologous residues to alpha(5) H105 in alpha(1) , alpha(2) , and alpha(3) are well-known determinants of the action of classical benzodiazepines.	Benzodiazepines	134-149	adrenoceptor alpha 1D	Homo sapiens	44-51
17953656-6	2007	The homologous residues to alpha(5) H105 in alpha(1) , alpha(2) , and alpha(3) are well-known determinants of the action of classical benzodiazepines.	Benzodiazepines	134-149	immunoglobulin binding protein 1	Homo sapiens	44-49
17953656-6	2007	The homologous residues to alpha(5) H105 in alpha(1) , alpha(2) , and alpha(3) are well-known determinants of the action of classical benzodiazepines.	Benzodiazepines	134-149	immunoglobulin binding protein 1	Homo sapiens	44-49
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Benzodiazepines	180-194	adrenoceptor alpha 1D	Homo sapiens	62-69
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Benzodiazepines	180-194	immunoglobulin binding protein 1	Homo sapiens	62-67
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Benzodiazepines	180-194	immunoglobulin binding protein 1	Homo sapiens	147-154
17953656-8	2007	Thus, the nature of the amino acid residue in this position is not only crucial for the action of classical benzodiazepines but in alpha(5) containing receptors also for the action of zolpidem.	Benzodiazepines	108-123	immunoglobulin binding protein 1	Homo sapiens	131-136
19300612-2	2007	Like other non-benzodiazepine hypnotics, its mechanism of action is to modulate subunits, especially the alpha-1 subunit, of the GABA receptor complex in order to induce sedation.	Benzodiazepines	15-29	adrenoceptor alpha 1D	Homo sapiens	105-112
17875639-4	2007	We used this mutant and PKCepsilon(-/-) mice to determine that PKCepsilon phosphorylates gamma2 subunits at serine 327 and that reduced phosphorylation of this site enhances the actions of ethanol and benzodiazepines at alpha1beta2gamma2 receptors, which is the most abundant GABA(A) receptor subtype in the brain.	Benzodiazepines	201-216	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	89-95
17762513-0	2007	Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid receptors.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	35-38
17705415-10	2007	Some of the mitochondrial localized photosensitizers showed a significant peripheral benzodiazepine binding (PBR) affinity.	Benzodiazepines	85-99	resistance to Paracoccidioides brasiliensis	Mus musculus	109-112
17919468-6	2007	Enhanced BDZ binding was found 1 week after SE in many cortical areas in P12 and also in the amygdala complex and dentate gyrus in both P12 and P25.	Benzodiazepines	9-12	lipocalin 2	Rattus norvegicus	144-147
17762513-1	2007	Withdrawal from 1-week oral administration of the benzodiazepine, flurazepam (FZP) is associated with increased alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor (AMPAR) miniature excitatory postsynaptic currents (mEPSCs) but reduction of N-methyl-D-aspartic acid (NMDA) receptor (NMDAR)-evoked (e)EPSCs in hippocampal CA1 neurons.	Benzodiazepines	50-64	carbonic anhydrase 1	Rattus norvegicus	342-345
17762513-6	2007	An evidence-based model of likely cellular mechanisms in the hippocampus contributing to benzodiazepine withdrawal anxiety was proposed implicating regulation of multiple CA1 neuron ion channels.	Benzodiazepines	89-103	carbonic anhydrase 1	Rattus norvegicus	171-174
17410605-1	2007	Midazolam (MDZ), a short-acting benzodiazepine, is a widely accepted probe drug for CYP3A phenotyping.	Benzodiazepines	32-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-89
17635335-0	2007	Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines.	Benzodiazepines	86-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	35-50
17635335-2	2007	Several benzodiazepines (BZPs) are metabolized predominantly or partly by polymorphic CYP2C19 and CYP3A4/5.	Benzodiazepines	8-23	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	86-93
17635335-2	2007	Several benzodiazepines (BZPs) are metabolized predominantly or partly by polymorphic CYP2C19 and CYP3A4/5.	Benzodiazepines	8-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104
17635335-2	2007	Several benzodiazepines (BZPs) are metabolized predominantly or partly by polymorphic CYP2C19 and CYP3A4/5.	Benzodiazepines	25-29	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	86-93
17635335-2	2007	Several benzodiazepines (BZPs) are metabolized predominantly or partly by polymorphic CYP2C19 and CYP3A4/5.	Benzodiazepines	25-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104
17635335-7	2007	Further studies on the effects of genetic polymorphisms of CYP enzymes on the pharmacokinetics and pharmacodynamics of BZPs are necessary to guide treatment individualization and optimization.	Benzodiazepines	119-123	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-62
17510319-0	2007	Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	85-90
17510319-0	2007	Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	184-187
17242090-4	2007	The IC50 of midazolam for orexin-A-evoked release (0.87 microM, P &lt; 0.01), which was insensitive to flumazenil, was significantly lower than that of diazepam and flunitrazepam (around 60 microM), whereas the IC50s for K+-evoked release were not different among the benzodiazepines.	Benzodiazepines	268-283	hypocretin neuropeptide precursor	Rattus norvegicus	26-34
17302280-1	2007	Imaging of microglia cells using the radiolabeled ligand toward peripheral benzodiazepine receptor(PBR) is applied to brain injury and neurodegenerative diseases.	Benzodiazepines	75-89	translocator protein	Homo sapiens	99-102
16919386-0	2007	Sensitivity of P-glycoprotein tryptophan residues to benzodiazepines and ATP interaction.	Benzodiazepines	53-68	ATP binding cassette subfamily B member 1	Homo sapiens	15-29
16919386-2	2007	In the present study tryptophan intrinsic fluorescence was used to understand the P-glycoprotein response to three benzodiazepines (bromazepam, chlordiazepoxide and flurazepam) in the presence and absence of ATP.	Benzodiazepines	115-130	ATP binding cassette subfamily B member 1	Homo sapiens	82-96
16919386-3	2007	Fluorescence emission spectra showed a red shift on the maximal emission wavelength upon interaction of P-glycoprotein with all benzodiazepines.	Benzodiazepines	128-143	ATP binding cassette subfamily B member 1	Homo sapiens	104-118
16919386-4	2007	Benzodiazepine association with nucleotide-bound P-glycoprotein also showed this trend and the quenching profile was attributed to a sphere-of-action model, for static fluorescence.	Benzodiazepines	0-14	ATP binding cassette subfamily B member 1	Homo sapiens	49-63
16919386-5	2007	Furthermore, quenching data of benzodiazepine-bound P-glycoprotein with ATP were concentration dependent and saturable, indicating that nucleotide binds to P-glycoprotein whether drug is present or not.	Benzodiazepines	31-45	ATP binding cassette subfamily B member 1	Homo sapiens	52-66
16919386-5	2007	Furthermore, quenching data of benzodiazepine-bound P-glycoprotein with ATP were concentration dependent and saturable, indicating that nucleotide binds to P-glycoprotein whether drug is present or not.	Benzodiazepines	31-45	ATP binding cassette subfamily B member 1	Homo sapiens	156-170
17927298-5	2007	The prescription of dependency-producing drugs (including benzodiazepine/cyclopyrrolone agents) in Denmark is regulated according to Danish directive CIR nr 12, introduced on 13 January 2003, which aimed for restrictions in the prescribing of benzodiazepine and cyclopyrrolone drugs while setting revised guidelines for the re-evaluation of these agents.	Benzodiazepines	58-72	corepressor interacting with RBPJ, CIR1	Homo sapiens	150-153
17927298-5	2007	The prescription of dependency-producing drugs (including benzodiazepine/cyclopyrrolone agents) in Denmark is regulated according to Danish directive CIR nr 12, introduced on 13 January 2003, which aimed for restrictions in the prescribing of benzodiazepine and cyclopyrrolone drugs while setting revised guidelines for the re-evaluation of these agents.	Benzodiazepines	243-257	corepressor interacting with RBPJ, CIR1	Homo sapiens	150-153
17696808-6	2007	The drug groups most implicated in CYP-mediated interactions with ARV drugs include: rifamycins; statins; antibiotics; antifungals; antiulcer drugs; contraceptives; immunosuppressant drugs; drugs for erectile dysfunction; drugs of abuse; drugs for treatment of addiction; benzodiazepines; anticonvulsants; psychotropic agents; herbal products; antiarrhythmias; antimalarials; anticoagulants; and antiasthma drugs.	Benzodiazepines	272-287	peptidylprolyl isomerase G	Homo sapiens	35-38
17484843-4	2007	Benzodiazepines, anticonvulsants and lithium salts should be avoided during treatment with ECT.	Benzodiazepines	0-15	ECT	Homo sapiens	91-94
17539703-9	2007	Receptors containing the alpha1, alpha2, or alpha3 subunits with gamma2 are usually found at synapses and are sensitive to benzodiazepines and zolpidem, whereas alpha4 and alpha6 subunits are often found with delta and play a role in extrasynaptic receptors (in thalamus and dentate), as does the alpha5 subunit (in CA1).	Benzodiazepines	123-138	adrenoceptor alpha 1D	Homo sapiens	25-39
17539703-9	2007	Receptors containing the alpha1, alpha2, or alpha3 subunits with gamma2 are usually found at synapses and are sensitive to benzodiazepines and zolpidem, whereas alpha4 and alpha6 subunits are often found with delta and play a role in extrasynaptic receptors (in thalamus and dentate), as does the alpha5 subunit (in CA1).	Benzodiazepines	123-138	carbonic anhydrase 1	Homo sapiens	316-319
16710315-0	2007	Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice.	Benzodiazepines	13-27	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	Mus musculus	105-117
17132386-0	2006	GPs" attitudes to benzodiazepine and "Z-drug" prescribing: a barrier to implementation of evidence and guidance on hypnotics.	Benzodiazepines	18-32	neurobeachin like 2	Homo sapiens	0-4
19412490-1	2006	Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient"s sleep, mood, daytime function, and quality of life.	Benzodiazepines	38-53	RLS1	Homo sapiens	172-175
16395302-0	2006	Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress.	Benzodiazepines	116-130	arginine vasopressin	Rattus norvegicus	34-45
17105517-2	2006	The medications used most commonly to treat RLS include dopaminergic drugs (levodopa, dopamine agonists), benzodiazepines, and narcotic analgesics.	Benzodiazepines	106-121	RLS1	Homo sapiens	44-47
17085856-4	2006	The non-selective adenosine receptor antagonist (caffeine), and the selective adenosine A1 receptor antagonist (DPCPX), injected 15 min before the application of pentetrazole and flumazenil, were able to intensify BDZ withdrawal signs in mice.	Benzodiazepines	214-217	adenosine A1 receptor	Mus musculus	78-99
17109943-2	2006	In previous experiments, overexpression of enkephalin in the amygdala enhanced the anxiolytic actions of the benzodiazepine agonist diazepam in the elevated plus maze.	Benzodiazepines	109-123	proenkephalin	Rattus norvegicus	43-53
16884554-0	2006	Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo.	Benzodiazepines	71-86	amyloid beta precursor protein	Rattus norvegicus	20-45
17156911-0	2006	The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.	Benzodiazepines	15-29	translocator protein	Homo sapiens	40-66
17156911-3	2006	Recent studies suggest that activated microglia in the CNS may be detected in vivo using positron emission tomography (PET) utilizing pharmacological ligands of the mitochondrial peripheral benzodiazepine receptor (PBR (recently renamed as Translocator protein (18kDa)).	Benzodiazepines	190-204	translocator protein	Homo sapiens	215-218
16889959-2	2006	In this regard, we have identified the piperidinyl-azabenzimidazolone and phenylimidazolinone structures which, when incorporated into the benzodiazepine core, afford potent CGRP receptor antagonists (e.g., 18 and 29).	Benzodiazepines	139-153	calcitonin related polypeptide alpha	Homo sapiens	174-178
16751446-9	2006	Deprivation gradients were particularly steep for benzodiazepines (IRR 5.63, 95% CI 1.72 to 18.40), antidepressants (IRR 4.58, 95% CI 1.80 to 11.66), cough and cold remedies (IRR 3.93, 95% CI 1.67 to 9.24), and organic solvents (IRR 3.69, 95% CI 1.83 to 7.44).	Benzodiazepines	50-65	insulin receptor related receptor	Homo sapiens	67-70
16945016-0	2006	Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).	Benzodiazepines	79-93	potassium voltage-gated channel subfamily KQT member 1	Cricetulus griseus	52-57
16205776-0	2006	A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.	Benzodiazepines	147-161	angiotensinogen	Rattus norvegicus	31-45
16205776-0	2006	A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.	Benzodiazepines	147-161	angiotensin II receptor, type 1a	Rattus norvegicus	46-49
16205776-8	2006	Pretreatment with the AT1 receptor antagonist completely prevented the decrease in cortical CRF1 receptor and benzodiazepine binding produced by isolation stress.	Benzodiazepines	110-124	angiotensin II receptor, type 1a	Rattus norvegicus	22-25
16554486-6	2006	An examination of synaptic and extrasynaptic GABA-mediated currents in cerebellar granule cells from Gabra6(100R/100R) and Gabra6(100Q/100Q) rats uncovered marked allele-dependent differences in benzodiazepine sensitivity.	Benzodiazepines	195-209	gamma-aminobutyric acid type A receptor subunit alpha6	Rattus norvegicus	101-117
16649882-5	2006	Benzodiazepine use during follow-up was associated with greater panic severity for those clients who received PCT, but no such relationship was found for TAU clients.	Benzodiazepines	0-14	calcitonin related polypeptide alpha	Homo sapiens	110-113
16554486-7	2006	Unexpectedly, we found that the benzodiazepines flunitrazepam and diazepam enhanced extrasynaptic inhibition mediated by delta subunit-containing GABARs in Gabra6(100Q/100Q) rats.	Benzodiazepines	32-47	gamma-aminobutyric acid type A receptor subunit alpha6	Rattus norvegicus	156-162
16452238-0	2006	The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation.	Benzodiazepines	21-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	86-91
16278829-0	2006	Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin.	Benzodiazepines	69-84	albumin	Homo sapiens	94-107
16278829-1	2006	The effects of (R)- and (S)-ibuprofen on the binding of benzodiazepines to human serum albumin (HSA) were examined by biointeraction chromatography.	Benzodiazepines	56-71	albumin	Homo sapiens	81-94
16168444-2	2006	An attempt has been made to investigate the role of GABA(A) receptors and their benzodiazepine site on the orexin-A induced response to feeding.	Benzodiazepines	80-94	hypocretin neuropeptide precursor	Rattus norvegicus	107-115
16842193-5	2006	There are several classes of PBR ligands available including benzodiazepines (Ro5-4864), isoquinoline carboxamides (PK 11195), indoleacetamides (FGIN-1-27), phenoxyphenyl-acetamides (DAA1106) and pyrazolopyrimidines (DPA-713).	Benzodiazepines	61-76	translocator protein	Homo sapiens	29-32
16189299-8	2006	It is noteworthy that the position of alpha4Glu59 within the neuronal nAChR is identical to that of a residue that lines the benzodiazepine-binding site on GABA(A) receptors.	Benzodiazepines	125-139	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	70-75
16684660-0	2006	On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.	Benzodiazepines	44-59	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	101-106
16185722-5	2006	Expression of egr-1 in the CeA and lateral nucleus of the amygdala following administration of anxiolytic and anxiogenic benzodiazepine and serotonin agonists and antagonists was investigated.	Benzodiazepines	121-135	early growth response 1	Homo sapiens	14-19
16174807-2	2005	In this study, a series of five benzodiazepines was used as prototypic CYP3A4 substrates to investigate the prediction of clearance from the less studied alternative in vitro system, cryopreserved human hepatocytes.	Benzodiazepines	32-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	71-77
16266690-0	2005	Benzodiazepine involvement in LTP of the GABA-ergic IPSC in rat hippocampal CA1 neurons.	Benzodiazepines	0-14	carbonic anhydrase 1	Rattus norvegicus	76-79
16382339-3	2005	Oxidative stress and protein tyrosine nitration (PTN) are also observed in response to ammonia, inflammatory cytokines, such as TNF-alpha or interferons, and benzodiazepines with affinity to the peripheral benzodiazepine receptor (PBR).	Benzodiazepines	158-173	pleiotrophin	Rattus norvegicus	49-52
16382339-3	2005	Oxidative stress and protein tyrosine nitration (PTN) are also observed in response to ammonia, inflammatory cytokines, such as TNF-alpha or interferons, and benzodiazepines with affinity to the peripheral benzodiazepine receptor (PBR).	Benzodiazepines	158-173	translocator protein	Rattus norvegicus	195-229
16382339-3	2005	Oxidative stress and protein tyrosine nitration (PTN) are also observed in response to ammonia, inflammatory cytokines, such as TNF-alpha or interferons, and benzodiazepines with affinity to the peripheral benzodiazepine receptor (PBR).	Benzodiazepines	158-173	translocator protein	Rattus norvegicus	231-234
16382339-5	2005	Cerebral PTN is also found in vivo after administration of ammonia, benzodiazepines or lipopolysaccharide and in portocaval shunted rats.	Benzodiazepines	68-83	pleiotrophin	Rattus norvegicus	9-12
16291941-5	2005	Together, these data show that potentiation of alpha3-containing GABA(A) receptors is sufficient to produce the anxiolytic effects of BZs and that alpha2 potentiation may not be necessary.	Benzodiazepines	134-137	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	47-53
16184188-1	2005	Classical benzodiazepines (BZs), such as diazepam, bind to GABAA receptors containing alpha1, alpha2, alpha3 or alpha5 subunits that are therefore described as diazepam-sensitive (DS) receptors.	Benzodiazepines	10-25	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	94-118
16184188-1	2005	Classical benzodiazepines (BZs), such as diazepam, bind to GABAA receptors containing alpha1, alpha2, alpha3 or alpha5 subunits that are therefore described as diazepam-sensitive (DS) receptors.	Benzodiazepines	27-30	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	94-118
15931077-1	2005	We compared the effects of midazolam, one of the popular benzodiazepines, on inhibitory postsynaptic currents in CA3 pyramidal cells with those in CA1 pyramidal cells in rat hippocampal slices.	Benzodiazepines	57-72	carbonic anhydrase 3	Rattus norvegicus	113-116
16195550-0	2005	Topology characterization of a benzodiazepine-binding beta-rich domain of the GABAA receptor alpha1 subunit.	Benzodiazepines	31-45	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	78-99
15814572-5	2005	GABARAP coexpression did not alter the general properties of GABA(A) receptors such as sensitivity to GABA or benzodiazepines, but it increased surface levels of receptor protein in oocytes.	Benzodiazepines	110-125	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	0-7
15342470-8	2004	The differences observed in the benzodiazepine metabolite pathway ratios between CYP3A4 and CYP3A5, particularly for 1"- to 4-hydroxymidazolam and alprazolam, provided a useful measure of interindividual differences within the CYP3A family.	Benzodiazepines	32-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
15926867-1	2005	Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of GABA at GABA(A) receptors containing either an alpha1, -2, -3 or -5 subunit.	Benzodiazepines	14-28	adrenoceptor alpha 1D	Homo sapiens	177-197
15926867-1	2005	Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of GABA at GABA(A) receptors containing either an alpha1, -2, -3 or -5 subunit.	Benzodiazepines	30-32	adrenoceptor alpha 1D	Homo sapiens	177-197
15842763-0	2005	Urine benzodiazepine screening using Roche Online KIMS immunoassay with beta-glucuronidase hydrolysis and confirmation by gas chromatography- mass spectrometry.	Benzodiazepines	6-20	glucuronidase beta	Homo sapiens	72-90
15716217-3	2005	Previous studies have suggested that dopaminergic drugs such as L-dopa and dopamine agonists, as well as benzodiazepines and opioids, can treat RLS successfully.	Benzodiazepines	105-120	RLS1	Homo sapiens	144-147
15618944-1	2005	Drugs modulating gamma-aminobutyric acid (GABA) transmission via the benzodiazepine (BZ) site on the gamma-aminobutyric acid type A (GABAA) receptor have been in widespread use for more than 40 years to treat anxiety, epilepsy, and sleep disorders.	Benzodiazepines	69-83	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	133-138
15618944-1	2005	Drugs modulating gamma-aminobutyric acid (GABA) transmission via the benzodiazepine (BZ) site on the gamma-aminobutyric acid type A (GABAA) receptor have been in widespread use for more than 40 years to treat anxiety, epilepsy, and sleep disorders.	Benzodiazepines	85-87	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	133-138
15618946-0	2005	Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs.	Benzodiazepines	118-132	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	24-29
15618946-2	2005	Research using transgenic mouse models has suggested that the effects of BZs involve multiple subtypes of the gamma-aminobutyric acid type A (GABAA) receptor, identified by specific a subunits (alpha1, alpha2, alpha3, alpha5).	Benzodiazepines	73-76	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	142-147
15618946-2	2005	Research using transgenic mouse models has suggested that the effects of BZs involve multiple subtypes of the gamma-aminobutyric acid type A (GABAA) receptor, identified by specific a subunits (alpha1, alpha2, alpha3, alpha5).	Benzodiazepines	73-76	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	210-224
16095696-6	2005	Local infusion into the dlPAG of a glutamate NMDA-receptor antagonist (AP7) or a benzodiazepine agonist (midazolam) completely prevented the flight reactions induced by intra-dlPAG administration of SIN-1, a NO donor.	Benzodiazepines	81-95	MAPK associated protein 1	Homo sapiens	199-204
15850489-1	2005	BACKGROUND: Gamma-aminobutyric acid type A receptors (GABAA-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics.	Benzodiazepines	189-204	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	54-59
15850489-14	2005	CONCLUSION: We conclude that: 1) insertion of a neomycin resistance gene into intron 8 of the gamma2 gene variably reduced the amount of gamma2, and that 2) attenuated expression of gamma2 increased anxiety-like behaviors but did not lead to differences in the hypnotic response to benzodiazepine site ligands.	Benzodiazepines	282-296	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	94-100
15850659-1	2005	Within the diseased brain, glial cells and in particular, microglia, express a multimeric protein complex termed "peripheral benzodiazepine binding sites (PBBS)" or "peripheral benzodiazepine receptor (PBR)".	Benzodiazepines	125-139	translocator protein	Homo sapiens	165-200
15666084-2	2005	PKC modulates GABA(A) receptor surface density, chloride conductance and receptor sensitivity to positive allosteric modulators such as neurosteroids, ethanol, benzodiazepines and barbiturates.	Benzodiazepines	160-175	protein kinase C, gamma	Mus musculus	0-3
15683150-2	2004	Presentation of patients with recurrent stupor associated with apparently elevated levels of an endogenous benzodiazepine-like agent, endozepine-4, has been reported from several centers, and a new syndrome, endozepine stupor has been proposed.	Benzodiazepines	107-121	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	134-144
15342470-1	2004	A systematic kinetic analysis of the metabolism of five benzodiazepines (low to high clearance compounds) was performed in CYP3A4, CYP3A5, and CYP2C19 baculovirus-expressed recombinant systems.	Benzodiazepines	56-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	143-150
15342470-6	2004	The use of quinidine 3-hydroxylation and alprazolam 1"-hydroxylation as RAF markers for CYP3A4 and CYP3A5 activity, respectively, and the incorporation of variability improved the clearance prediction of the selected benzodiazepines (apart from flunitrazepam) to within 2-fold of the in vivo value.	Benzodiazepines	217-232	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	99-105
15342470-8	2004	The differences observed in the benzodiazepine metabolite pathway ratios between CYP3A4 and CYP3A5, particularly for 1"- to 4-hydroxymidazolam and alprazolam, provided a useful measure of interindividual differences within the CYP3A family.	Benzodiazepines	32-46	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	92-98
15266351-0	2004	Transient plasticity of hippocampal CA1 neuron glutamate receptors contributes to benzodiazepine withdrawal-anxiety.	Benzodiazepines	82-96	carbonic anhydrase 1	Rattus norvegicus	36-39
15536461-1	2004	Sixty-one healthy men and women, aged 20 to 75 years, received single 0.25-mg doses of triazolam, a cytochrome P450 (CYP) 3A substrate benzodiazepine, and placebo in a double-blind crossover study.	Benzodiazepines	135-149	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-124
15266351-1	2004	Withdrawal from 1-week oral administration of the benzodiazepine (BZ), flurazepam (FZP) is associated with enhanced AMPA receptor (AMPAR)-mediated and reduced NMDA receptor (NMDAR)-mediated excitation in CA1 pyramidal neurons 2-days after cessation of FZP administration.	Benzodiazepines	50-64	carbonic anhydrase 1	Rattus norvegicus	204-207
15266351-1	2004	Withdrawal from 1-week oral administration of the benzodiazepine (BZ), flurazepam (FZP) is associated with enhanced AMPA receptor (AMPAR)-mediated and reduced NMDA receptor (NMDAR)-mediated excitation in CA1 pyramidal neurons 2-days after cessation of FZP administration.	Benzodiazepines	66-68	carbonic anhydrase 1	Rattus norvegicus	204-207
15266351-9	2004	These findings suggest that increased CA1 neuron AMPAR-mediated excitation may contribute to hippocampal hyperexcitability and expression of withdrawal-anxiety after prolonged BZ exposure via NMDAR-mediated neural circuits.	Benzodiazepines	176-178	carbonic anhydrase 1	Rattus norvegicus	38-41
15470333-3	2004	Accordingly, the disposition of 3 closely related benzodiazepines with extensive and similar CYP3A-mediated metabolism characteristics but different pharmacokinetics was investigated, and correlations between the drugs were examined.	Benzodiazepines	50-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-98
15258104-1	2004	The role of P-glycoprotein (P-gp) on the distribution of the benzodiazepine triazolam (TRZ) and the azole antifungal agent ketoconazole (KET), and on the TRZ-KET interaction, was studied using mdr1a(-) or mdr1a/b(-/-) mice (P-gp-deficient mice) and matched controls.	Benzodiazepines	61-75	phosphoglycolate phosphatase	Mus musculus	12-26
15248604-2	2004	Esters with chloro or acetyl groups at C-1 showed high affinity for the brain benzodiazepine recognition site.	Benzodiazepines	78-92	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	39-42
15219633-8	2004	Patients with more severe benzodiazepine withdrawal (CIWA-B-increase &gt; 14 pts; n = 7) showed a significant higher cortisol and ACTH response in the dexamethasone/CRH test preceding the discontinuation of benzodiazepines than patients displaying less severe withdrawal symptoms (CIWA-B-increase &lt;14 pts.	Benzodiazepines	26-40	corticotropin releasing hormone	Homo sapiens	165-168
15219633-8	2004	Patients with more severe benzodiazepine withdrawal (CIWA-B-increase &gt; 14 pts; n = 7) showed a significant higher cortisol and ACTH response in the dexamethasone/CRH test preceding the discontinuation of benzodiazepines than patients displaying less severe withdrawal symptoms (CIWA-B-increase &lt;14 pts.	Benzodiazepines	207-222	corticotropin releasing hormone	Homo sapiens	165-168
15261259-0	2004	Benzodiazepine inhibitors of the MMPs and TACE.	Benzodiazepines	0-14	ADAM metallopeptidase domain 17	Homo sapiens	42-46
15261259-2	2004	A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model.	Benzodiazepines	12-26	ADAM metallopeptidase domain 17	Homo sapiens	31-35
15261259-2	2004	A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model.	Benzodiazepines	12-26	tumor necrosis factor	Homo sapiens	159-162
15219633-11	2004	In view of the GABAergic inhibition of HPA system activity and the anxiogenic effect of CRH, benzodiazepine withdrawal symptoms may be partly due to a disinhibition of the HPA system during discontinuation of benzodiazepines.	Benzodiazepines	93-107	corticotropin releasing hormone	Homo sapiens	88-91
15219633-11	2004	In view of the GABAergic inhibition of HPA system activity and the anxiogenic effect of CRH, benzodiazepine withdrawal symptoms may be partly due to a disinhibition of the HPA system during discontinuation of benzodiazepines.	Benzodiazepines	209-224	corticotropin releasing hormone	Homo sapiens	88-91
15258104-1	2004	The role of P-glycoprotein (P-gp) on the distribution of the benzodiazepine triazolam (TRZ) and the azole antifungal agent ketoconazole (KET), and on the TRZ-KET interaction, was studied using mdr1a(-) or mdr1a/b(-/-) mice (P-gp-deficient mice) and matched controls.	Benzodiazepines	61-75	phosphoglycolate phosphatase	Mus musculus	28-32
15125950-2	2004	These compounds have consistently higher binding affinity for the GABAA alpha5 receptor subtype over the other benzodiazepine-sensitive GABAA receptor subtypes (alpha1, alpha2 and alpha3).	Benzodiazepines	111-125	adrenoceptor alpha 1D	Homo sapiens	161-167
15254090-0	2004	Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors.	Benzodiazepines	19-33	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	56-71
15254090-9	2004	These data indicate that BZ-resistant anxiety results from a developmental arrest of GABA(A)R expression in SW-R-/- mice, and a similar mechanism may be responsible for the BZ insensitivity of some anxiety patients.	Benzodiazepines	25-27	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	85-93
15273980-5	2004	In CEC with NAIP, the benzodiazepines were separated by the combination of hydrophobic and pi-pi interactions, whereas the separation of the barbiturates was based on the hydrophobic interaction.	Benzodiazepines	22-37	NLR family apoptosis inhibitory protein	Homo sapiens	12-16
15136793-2	2004	Since benzodiazepines work through facilitation of GABAergic inhibitory neurotransmission, this study was designed to determine whether the direct-acting gamma-aminobutyric acidA (GABAA) receptor agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) evokes behavioral effects similar to those of benzodiazepines and whether behavioral effects of THIP are also NO dependent.	Benzodiazepines	6-21	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	180-185
15148255-9	2004	4 There are similarities between amino-acid sequences in human glucose transport protein isoform 1 (GLUT1) and the benzodiazepine-binding domains of GABAA (gamma amino butyric acid) receptor subunits.	Benzodiazepines	115-129	solute carrier family 2 member 1	Homo sapiens	63-98
15157182-6	2004	Ideally, the mutation should leave normal receptor function intact, and this is the case with mutations affecting the BZ-binding site of the GABAA receptor.	Benzodiazepines	118-120	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	141-146
15148255-9	2004	4 There are similarities between amino-acid sequences in human glucose transport protein isoform 1 (GLUT1) and the benzodiazepine-binding domains of GABAA (gamma amino butyric acid) receptor subunits.	Benzodiazepines	115-129	solute carrier family 2 member 1	Homo sapiens	100-105
15130769-5	2004	PBR-specific drug ligands, the isoquinoline carboxamide PK 11195 and the benzodiazepine Ro5-4864, at relative high concentrations (10(-4)M), exert a strong inhibitory effect on cell proliferation by arresting the cells at the G0/G1 phase of the cell cycle, while no apoptotic cell death was observed.	Benzodiazepines	73-87	translocator protein	Homo sapiens	0-3
15291240-2	2004	Diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide, significantly increases in brains only after treatment with psychological stress, and this increase is completely abolished by benzodiazepines.	Benzodiazepines	200-215	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-26
15291240-2	2004	Diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide, significantly increases in brains only after treatment with psychological stress, and this increase is completely abolished by benzodiazepines.	Benzodiazepines	200-215	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	28-31
15291242-5	2004	Recently it has been suggested that the combination of SSRI and benzodiazepine is rational, because each drug has a different mechanism of action, the benzodiazepines enhancing GABAergic transmission, and the SSRIs stimulating the 5-HT1A receptor that may inhibit the postsynaptic neuronal excitability in the amygdala and the prefrontal cortex that comprise the brain circuit of fear and anxiety.	Benzodiazepines	64-78	5-hydroxytryptamine receptor 1A	Homo sapiens	231-246
15067724-1	2004	The basolateral amygdala (ABL) is essential for the amnestic effects of benzodiazepines in aversive learning tasks.	Benzodiazepines	72-87	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-29
15067724-10	2004	The activation of alpha1-containing GABA(A) receptors in the ABL by benzodiazepines may disrupt rhythmic oscillations critical for memory consolidation.	Benzodiazepines	68-83	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-64
15134514-5	2004	Up to now, a large number of potent and selective GP IIb/IIIa antagonists, including non-peptide inhibitors are identified (derivatives of benzodiazepines, aminobenzamidinosuccinyles, isoxazolines, isoquinolines).	Benzodiazepines	139-154	integrin subunit alpha 2b	Homo sapiens	50-56
14742750-1	2004	Corticotropin-releasing factor(1) (CRF(1)) antagonists may be effective in the treatment of anxiety disorders with fewer side effects compared with classic benzodiazepines.	Benzodiazepines	156-171	corticotropin releasing hormone receptor 1	Rattus norvegicus	35-41
15109994-7	2004	A possible role for the deleted beta(3) subunit gene in PWS is supported in part by the wide cortical distribution of its mRNA expression and the effects of experimental knockouts on benzodiazepine binding described in prior studies.	Benzodiazepines	183-197	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	32-39
14742750-13	2004	This level of CRF(1) receptor occupancy resulted in fewer motoric side effects compared with classic benzodiazepines.	Benzodiazepines	101-116	corticotropin releasing hormone receptor 1	Rattus norvegicus	14-20
15082872-6	2004	The above results indicate that selective mGluR1 antagonist AIDA induces antianxiety-like effects at a low risk of acute side effects characteristic of benzodiazepines.	Benzodiazepines	152-167	glutamate metabotropic receptor 1	Rattus norvegicus	42-48
15102335-0	2004	Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124].	Benzodiazepines	26-41	insulin	Homo sapiens	45-52
14647970-11	2004	CONCLUSIONS: Benzodiazepine antagonists, particularly those acting preferentially at GABAA/alpha1 subunit-containing receptors, decrease alcohol-heightened and species-typical aggressive behavior, but are ineffective in attenuating the sedative effects of alcohol.	Benzodiazepines	13-27	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	85-90
15822631-8	2004	The most important pharmacologic treatment used in RLS includes L-DOPA, dopamine agonists, opiates, anticonvulsants and benzodiazepines.	Benzodiazepines	120-135	RLS1	Homo sapiens	51-54
14761188-1	2004	Three angiotensin II (Ang II) analogues encompassing a benzodiazepine-based gamma-turn-like scaffold have been synthesized.	Benzodiazepines	55-69	angiotensinogen	Rattus norvegicus	6-20
14761188-1	2004	Three angiotensin II (Ang II) analogues encompassing a benzodiazepine-based gamma-turn-like scaffold have been synthesized.	Benzodiazepines	55-69	angiotensinogen	Rattus norvegicus	22-28
14723961-4	2004	The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives.	Benzodiazepines	92-106	translocator protein	Rattus norvegicus	72-75
14697893-3	2004	Several components selectively inhibiting MAO A, MAO B, central and peripheral benzodiazepine binding (tribulins A, B, BZc and BZp, respectively) have been recognised.	Benzodiazepines	79-93	zinc finger E-box binding homeobox 1	Homo sapiens	127-130
14678758-3	2003	Because the functional role of the PBR is unknown, we confirm by immunohistochemistry and PCR (I) that this receptor is expressed on microglia in vitro and (II) that benzodiazepines modulate proliferation of microglial cells and the release of the inflammatory molecules nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in cell culture supernatants of primary rat microglia.	Benzodiazepines	166-181	translocator protein	Rattus norvegicus	35-38
15669223-3	2004	Recently it has been suggested that the combination of SSRI and benzodiazepine is rational, because each drug has a different mechanism of action, the benzodiazepine enhancing GABAergic transmission, the SSRIs stimulating the 5-HT1A receptor that may inhibit the postsynaptic neuronal excitability in the amygdala and the prefrontal cortex that comprise the brain circuit of fear and anxiety.	Benzodiazepines	64-78	5-hydroxytryptamine receptor 1A	Homo sapiens	226-241
15505688-2	2004	Molecular studies have shown that binding benzodiazepines to GABAA receptors containing the Alpha1 subunit mediates the sedative properties of benzodiazepines.	Benzodiazepines	42-57	adrenoceptor alpha 1D	Homo sapiens	92-98
15505688-2	2004	Molecular studies have shown that binding benzodiazepines to GABAA receptors containing the Alpha1 subunit mediates the sedative properties of benzodiazepines.	Benzodiazepines	143-158	adrenoceptor alpha 1D	Homo sapiens	92-98
14678758-3	2003	Because the functional role of the PBR is unknown, we confirm by immunohistochemistry and PCR (I) that this receptor is expressed on microglia in vitro and (II) that benzodiazepines modulate proliferation of microglial cells and the release of the inflammatory molecules nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in cell culture supernatants of primary rat microglia.	Benzodiazepines	166-181	tumor necrosis factor	Rattus norvegicus	293-320
14678758-3	2003	Because the functional role of the PBR is unknown, we confirm by immunohistochemistry and PCR (I) that this receptor is expressed on microglia in vitro and (II) that benzodiazepines modulate proliferation of microglial cells and the release of the inflammatory molecules nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in cell culture supernatants of primary rat microglia.	Benzodiazepines	166-181	tumor necrosis factor	Rattus norvegicus	322-331
14678758-5	2003	Moreover, release of TNF-alpha and proliferation was significantly inhibited in the benzodiazepine-treated groups.	Benzodiazepines	84-98	tumor necrosis factor	Rattus norvegicus	21-30
14597328-2	2003	When expressed in Xenopus oocytes, the gamma2 subunit R43Q mutation abolished current enhancement by the benzodiazepine, diazepam, and the gamma2 subunit K289M mutation decreased current amplitudes.	Benzodiazepines	105-119	tryptophanyl-tRNA synthetase 1	Homo sapiens	39-45
15206488-6	2003	Our data show that patients with levels of beta-endorphin over 8 pmol/L were less sensitive to pain, so that they become candidates for a traditional utilization of the benzodiazepines.	Benzodiazepines	169-184	proopiomelanocortin	Homo sapiens	43-57
14687385-8	2003	After adjustment for baseline physical performance score and potential confounders, benzodiazepine use was associated with a greater decline in physical performance over 4 years than nonuse (beta=-1.16; standard error (SE)=0.25; P&lt;.001).	Benzodiazepines	84-98	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	191-198
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	17-31	adrenoceptor alpha 1D	Homo sapiens	185-193
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	17-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	195-202
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	367-369	adrenoceptor alpha 1D	Homo sapiens	185-193
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	33-35	adrenoceptor alpha 1D	Homo sapiens	185-193
14573876-7	2003	The finding that the BZ binding affinity of these recombinant domains was highest for the gamma(2) subunit and lowest for the beta(2) subunit is consistent with results from previous binding studies using hetero-oligomeric receptors.	Benzodiazepines	21-23	tryptophanyl-tRNA synthetase 1	Homo sapiens	90-98
14573876-7	2003	The finding that the BZ binding affinity of these recombinant domains was highest for the gamma(2) subunit and lowest for the beta(2) subunit is consistent with results from previous binding studies using hetero-oligomeric receptors.	Benzodiazepines	21-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	126-133
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	33-35	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	195-202
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	33-35	tryptophanyl-tRNA synthetase 1	Homo sapiens	208-216
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	33-35	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	320-327
14573876-6	2003	In addition, the benzodiazepine (BZ)-binding affinity of the recombinant fragments were measured using fluorescence polarization to be 2.16 microM, 3.63 microM, and 1.34 microM for the alpha(1), beta(2), and gamma(2) subunit fragments, respectively, indicating that all three homomeric assemblies, including that of the beta(2) subunit, generally not associated with BZ binding, can bind BZ in the micromolar range.	Benzodiazepines	367-369	adrenoceptor alpha 1D	Homo sapiens	185-193
12871032-3	2003	The molecular mechanisms of BZs are now well defined in that they enhance the actions of the inhibitory neurotransmitter GABA by binding to a specific recognition site on GABA(A) receptors containing alpha1, alpha2, alpha3 and alpha5 subunits.	Benzodiazepines	28-31	adrenoceptor alpha 1D	Homo sapiens	200-233
12919154-0	2003	Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans.	Benzodiazepines	14-28	GABA type A receptor-associated protein	Homo sapiens	40-53
12723943-2	2003	Novel benzodiazepines were designed that display subnanomolar affinity for the bradykinin B(1) receptor (K(i) = 0.59 nM) and high selectivity against the bradykinin B(2) receptor (K(i) &gt; 10 microM).	Benzodiazepines	6-21	bradykinin receptor B1	Homo sapiens	79-103
12815162-0	2003	Molecular determinants of KCNQ1 channel block by a benzodiazepine.	Benzodiazepines	51-65	potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog	Xenopus laevis	26-31
12927097-5	2003	In order to demonstrate this method, the data set of benzodiazepine derivatives, antagonists of (CCK-B), was used as a test sample.	Benzodiazepines	53-67	cholecystokinin B receptor	Homo sapiens	97-102
12716430-0	2003	Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine treatment.	Benzodiazepines	96-110	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	8-24
12717139-0	2003	Potentiation of proopiomelanocortin gene expression in cultured pituitary cells by benzodiazepines.	Benzodiazepines	83-98	pro-opiomelanocortin-alpha	Mus musculus	16-35
12717139-12	2003	CONCLUSIONS: Benzodiazepines potentiate the effect of CRH or forskolin on proopiomelanocortin gene expression.	Benzodiazepines	13-28	corticotropin releasing hormone	Mus musculus	54-57
12717139-12	2003	CONCLUSIONS: Benzodiazepines potentiate the effect of CRH or forskolin on proopiomelanocortin gene expression.	Benzodiazepines	13-28	pro-opiomelanocortin-alpha	Mus musculus	74-93
12716430-0	2003	Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine treatment.	Benzodiazepines	96-110	carbonic anhydrase 1	Rattus norvegicus	58-61
12716430-1	2003	One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus.	Benzodiazepines	28-42	carbonic anhydrase 1	Rattus norvegicus	234-237
12716430-1	2003	One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus.	Benzodiazepines	44-46	carbonic anhydrase 1	Rattus norvegicus	234-237
12743621-2	2003	The observed modulation of benzodiazepine receptors by CCK-8 in vitro might explain some of the functional interactions between CCK and benzodiazepine systems.	Benzodiazepines	27-41	cholecystokinin	Rattus norvegicus	55-58
12716027-4	2003	Ligand autoradiography revealed a significant reduction in baseline benzodiazepine and chloride channel site-bindings in various regions of the alpha6 -/- brains, but the chronic diazepam treatment did not consistently alter baseline or benzodiazepine site agonist and inverse agonist-modulated binding in the alpha6 -/- and wildtype mice.	Benzodiazepines	68-82	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	144-150
14593758-4	2003	Favorable outcomes attained in the treatment of RLS with the opioid receptor agonists, anticonvulsants, benzodiazepines, and adrenolytic agents are also reported.	Benzodiazepines	104-119	RLS1	Homo sapiens	48-51
12672542-4	2003	Binding of GABA(A) receptor channel ([(35)S]t-butylbicyclophosphorothionate) and benzodiazepine ([(3)H]Ro 15-4513) site ligands was reduced in selected brain regions of the beta3-deficient mice as compared to controls, while the UBE3A-deficient mice failed to show reduced GABA(A) receptors.	Benzodiazepines	81-95	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	173-178
12672542-4	2003	Binding of GABA(A) receptor channel ([(35)S]t-butylbicyclophosphorothionate) and benzodiazepine ([(3)H]Ro 15-4513) site ligands was reduced in selected brain regions of the beta3-deficient mice as compared to controls, while the UBE3A-deficient mice failed to show reduced GABA(A) receptors.	Benzodiazepines	81-95	ubiquitin protein ligase E3A	Mus musculus	229-234
12743621-2	2003	The observed modulation of benzodiazepine receptors by CCK-8 in vitro might explain some of the functional interactions between CCK and benzodiazepine systems.	Benzodiazepines	27-41	cholecystokinin	Rattus norvegicus	128-131
12474122-11	2002	CONCLUSIONS: These data suggest that the CRF(1) antagonist DMP696 might retain the therapeutic benefits of classical benzodiazepines but have fewer motoric side effects.	Benzodiazepines	117-132	corticotropin releasing hormone receptor 1	Rattus norvegicus	41-47
12642390-4	2003	(2) The UNC-49 subunits are most closely related to the bicuculline- and benzodiazepine-insensitive RDL GABA receptors of insects.	Benzodiazepines	73-87	Neur_chan_LBD domain-containing protein;Neur_chan_memb domain-containing protein;Uncharacterized protein	Caenorhabditis elegans	8-14
12614388-15	2003	This strongly suggests that allosteric modulation of the antiseizure activity of a GAT-1 inhibitor by a benzodiazepine does not offer a therapeutic advantage.	Benzodiazepines	104-118	solute carrier family 6 member 12	Rattus norvegicus	83-88
24930414-7	2003	A less likely explanation for the interaction between venlafaxine and benzodiazepines would be CYP 3A3/4 deficiency, which might potentiate the increase in plasma levels of benzodiazepines, thereby increasing their adverse effect potential.	Benzodiazepines	70-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-102
24930414-7	2003	A less likely explanation for the interaction between venlafaxine and benzodiazepines would be CYP 3A3/4 deficiency, which might potentiate the increase in plasma levels of benzodiazepines, thereby increasing their adverse effect potential.	Benzodiazepines	173-188	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-102
12490572-3	2003	Both alpha1 (-/-) and beta2 (-/-) null mutant mice showed markedly decreased sleep time induced by nonselective benzodiazepine, flurazepam, and GABAA agonist, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol.	Benzodiazepines	112-126	hemoglobin, beta adult minor chain	Mus musculus	5-27
12926546-0	2003	Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice.	Benzodiazepines	132-147	nitric oxide synthase 1, neuronal	Mus musculus	47-77
12540783-3	2003	In cultured rat astrocytes, diazepam, PK11195, Ro5-4864, and the benzodiazepine binding inhibitor (DBI), which acts on peripheral-type benzodiazepine receptors, induced PTN.	Benzodiazepines	65-79	pleiotrophin	Rattus norvegicus	169-172
12540783-10	2003	In conclusion, production of ROIs and increased PTN by benzodiazepines may alter astrocyte function and thereby contribute to the precipitation of HE episodes.	Benzodiazepines	55-70	pleiotrophin	Rattus norvegicus	48-51
12543492-1	2002	Stereoselective binding of benzodiazepine and coumarin drugs to serum albumin from human and six mammalian species were studied by chiral chromatographic techniques.	Benzodiazepines	27-41	albumin	Homo sapiens	64-77
12433804-4	2002	Data showing several benzodiazepines and alternative substrates interacting competitively support previous work, which indicates a single binding domain within UGT2B7.	Benzodiazepines	21-36	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	160-166
12472946-7	2002	Several proteins, which are nitrated in response to ammonia, benzodiazepines, hypoosmotic astrocyte swelling or inflammatory cytokines have been identified, including glutamine synthetase and the peripheral type benzodiazepine receptor.	Benzodiazepines	61-76	glutamate-ammonia ligase	Homo sapiens	167-187
12472946-7	2002	Several proteins, which are nitrated in response to ammonia, benzodiazepines, hypoosmotic astrocyte swelling or inflammatory cytokines have been identified, including glutamine synthetase and the peripheral type benzodiazepine receptor.	Benzodiazepines	61-76	translocator protein	Homo sapiens	196-235
12474122-1	2002	RATIONALE: CRF(1) antagonists may be effective in the treatment of anxiety disorders while having fewer side effects compared with classical benzodiazepines.	Benzodiazepines	141-156	corticotropin releasing hormone receptor 1	Rattus norvegicus	11-16
12451290-1	2002	The authors report preliminary findings on the potential contribution of CYP2C19 isoenzyme to the human metabolism of N-desmethylclobazam (N-CLB), the main active metabolite of clobazam (CLB), a benzodiazepine frequently used as add-on therapy in patients with refractory epilepsy.	Benzodiazepines	195-209	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	73-80
12171574-5	2002	The binding pocket for benzodiazepines is located in a subunit cleft between gamma2 and alpha1 subunits in a position homologous to the agonist binding site for GABA that is located between alpha1 and beta2 subunits.	Benzodiazepines	23-38	tryptophanyl-tRNA synthetase 1	Homo sapiens	77-94
12530641-8	2002	A 7-mer competitive PBR peptide antagonist was identified, which when transduced into Leydig cells inhibited the benzodiazepine and hormone-stimulated steroid production suggesting that the endogenous PBR agonist/receptor interaction is critical for the hormone-dependent steroidogenesis.	Benzodiazepines	113-127	translocator protein	Mus musculus	20-23
12530641-8	2002	A 7-mer competitive PBR peptide antagonist was identified, which when transduced into Leydig cells inhibited the benzodiazepine and hormone-stimulated steroid production suggesting that the endogenous PBR agonist/receptor interaction is critical for the hormone-dependent steroidogenesis.	Benzodiazepines	113-127	translocator protein	Mus musculus	201-204
12404077-9	2002	CONCLUSIONS: GABAA/alpha1 receptor mechanisms appear to play a key role in the ataxic effects of benzodiazepine agonists in squirrel monkeys, similar to recent results with transgenic mice.	Benzodiazepines	97-111	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	13-18
12404077-10	2002	In contrast to the findings of these recent studies, GABAA mechanisms other than or in addition to those mediated at the alpha1 subunit may play a more important role in the sedative/hypnotic effects of benzodiazepines in squirrel monkeys.	Benzodiazepines	203-218	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	53-58
12270165-0	2002	Benzodiazepine inhibitors of the MMPs and TACE.	Benzodiazepines	0-14	ADAM metallopeptidase domain 17	Homo sapiens	42-46
12270165-1	2002	A series of benzodiazepine inhibitors of the MMPs and TACE has been developed.	Benzodiazepines	12-26	ADAM metallopeptidase domain 17	Homo sapiens	54-58
12358754-0	2002	Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor alpha1 subunit modulates benzodiazepine binding.	Benzodiazepines	102-116	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	62-83
12367605-0	2002	Chronic benzodiazepine administration alters hippocampal CA1 neuron excitability: NMDA receptor function and expression(1).	Benzodiazepines	8-22	carbonic anhydrase 1	Rattus norvegicus	57-60
12367605-8	2002	These findings suggest that reduced NMDAR-mediated currents associated with chronic BZ treatment may be related to reduced NR2B subunit-containing NMDARs in the CA1 and CA2 regions.	Benzodiazepines	84-86	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	123-127
12367605-8	2002	These findings suggest that reduced NMDAR-mediated currents associated with chronic BZ treatment may be related to reduced NR2B subunit-containing NMDARs in the CA1 and CA2 regions.	Benzodiazepines	84-86	carbonic anhydrase 1	Rattus norvegicus	161-164
12367605-8	2002	These findings suggest that reduced NMDAR-mediated currents associated with chronic BZ treatment may be related to reduced NR2B subunit-containing NMDARs in the CA1 and CA2 regions.	Benzodiazepines	84-86	carbonic anhydrase 2	Rattus norvegicus	169-172
12367615-0	2002	The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes.	Benzodiazepines	78-93	tryptophanyl-tRNA synthetase 1 S homeolog	Xenopus laevis	39-45
12171574-5	2002	The binding pocket for benzodiazepines is located in a subunit cleft between gamma2 and alpha1 subunits in a position homologous to the agonist binding site for GABA that is located between alpha1 and beta2 subunits.	Benzodiazepines	23-38	adrenoceptor alpha 1D	Homo sapiens	88-94
12171574-5	2002	The binding pocket for benzodiazepines is located in a subunit cleft between gamma2 and alpha1 subunits in a position homologous to the agonist binding site for GABA that is located between alpha1 and beta2 subunits.	Benzodiazepines	23-38	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	201-206
12211123-9	2002	Predictors of BZD-use and clustering of traits: Dysthymic disorder was predictive of BZD-use (odds ratio (OR) 6.3 [95% confidence intervals (CI) 2.2-18.2]).	Benzodiazepines	85-88	olfactory receptor family 2 subfamily H member 4 pseudogene	Homo sapiens	94-113
12213255-0	2002	Selective enhancement of AMPA receptor-mediated function in hippocampal CA1 neurons from chronic benzodiazepine-treated rats.	Benzodiazepines	97-111	carbonic anhydrase 1	Rattus norvegicus	72-75
12404077-3	2002	The purpose of the present study was to investigate the role of GABAA/alpha1 receptors in the sedative and motor-impairing effects of benzodiazepines.	Benzodiazepines	134-149	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	Mus musculus	64-76
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Benzodiazepines	256-270	glutamic acid decarboxylase 2	Mus musculus	106-112
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Benzodiazepines	256-270	glutamic acid decarboxylase 2	Mus musculus	186-192
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Benzodiazepines	256-270	glutamic acid decarboxylase 2	Mus musculus	186-192
12213255-1	2002	Two days following one-week administration of the benzodiazepine, flurazepam (FZP), rats exhibit anticonvulsant tolerance in vivo, while reduced GABA(A) receptor-mediated inhibition and enhanced EPSP amplitude are present in CA1 pyramidal neurons in vitro.	Benzodiazepines	50-64	carbonic anhydrase 1	Rattus norvegicus	225-228
12035937-3	2002	However, the effect of benzodiazepines on the HPA response to CRH or AVP is contradictory.	Benzodiazepines	23-38	corticotropin releasing hormone	Homo sapiens	62-65
12023539-1	2002	In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand, 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575), in models of central and peripheral neurodegeneration in vivo and its effect on steroid concentrations in plasma and nervous tissue.	Benzodiazepines	103-117	translocator protein	Rattus norvegicus	132-135
12002608-1	2002	The diazepam binding inhibitor (DBI) was originally isolated from the brain as an intrinsic ligand of the benzodiazepine binding site on the type-A gamma-aminobutyric acid receptor (GABA(A) receptor).	Benzodiazepines	106-120	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	4-36
11850104-6	2002	The benzodiazepine Ro5-4864 and the isoquinoline carboxamide PK11195 exhibit nanomolar affinity for the PBR, and are the archtypic pharmacological tools for characterizing the receptor and its function.	Benzodiazepines	4-18	translocator protein	Homo sapiens	104-107
11792462-0	2002	Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells.	Benzodiazepines	0-15	excitatory amino acid transporter 1	Cricetulus griseus	43-48
11812253-6	2002	QSAR studies have been reported on different classes of CCK antagonists, e.g., benzodiazepine derivatives, amino acid derivatives, quinazolinones, and peptides and pseudopeptide analogs.	Benzodiazepines	79-93	cholecystokinin	Homo sapiens	56-59
11740952-0	2001	Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.	Benzodiazepines	15-29	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	75-92
12043833-13	2001	Rasagiline interacts with and prevents the binding of PKI 1195 to the pro-apoptotic peripheral benzodiazepine receptor, which together with Bcl-2, hexokinase, porin, and adenine nucleotide translocator constitutes part of the VDAC.	Benzodiazepines	95-109	BCL2, apoptosis regulator	Rattus norvegicus	140-145
11600302-4	2001	Column switching was employed to elute the extracted analytes from the ADS column into a high-performance liquid chromatography reverse-phase C18 column for the isocratic separation and UV detection of the benzodiazepines.	Benzodiazepines	206-221	Bardet-Biedl syndrome 9	Homo sapiens	142-145
11353808-4	2001	R1 compounds competitively inhibited binding of benzodiazepines in alpha1beta2gamma2 receptors, and their functional effects were partially inhibited by the benzodiazepine antagonist Ro15-1788 in a noncompetitive manner.	Benzodiazepines	48-63	CD1b molecule	Homo sapiens	0-2
11731013-0	2001	Structural requirements of benzodiazepines for the inhibition of pig brain nitric oxide synthase.	Benzodiazepines	27-42	nitric oxide synthase 2	Sus scrofa	75-96
11757913-1	2001	The diazepam binding inhibitor (DBI), initially isolated as an endogenous 10-kDa polypeptide from the brain, has the ability to displace ligands from benzodiazepine binding sites on gamma-aminobutyric acid (GABA) receptors.	Benzodiazepines	150-164	diazepam binding inhibitor	Mus musculus	4-30
11757913-1	2001	The diazepam binding inhibitor (DBI), initially isolated as an endogenous 10-kDa polypeptide from the brain, has the ability to displace ligands from benzodiazepine binding sites on gamma-aminobutyric acid (GABA) receptors.	Benzodiazepines	150-164	diazepam binding inhibitor	Mus musculus	32-35
15965850-3	2001	The 5-HT1A partial agonist, buspirone (Bristol-Myers-Squibb), is one of the few compounds developed principally as an anxiolytic since the benzodiazepines.	Benzodiazepines	139-154	5-hydroxytryptamine receptor 1A	Homo sapiens	4-10
11776290-5	2001	As expected, the CoMSIA 3D contour maps have provided more information on the benzodiazepine interaction mode with the PDE4 active site whereas CoMFA has built the best tool for activity prediction.	Benzodiazepines	78-92	phosphodiesterase 4A	Homo sapiens	119-123
11480834-4	2001	This case series suggests that manualized CBT for discontinuation of benzodiazepine treatment for panic disorder may be successfully applied to SSRI discontinuation as well.	Benzodiazepines	69-83	opsin 1, short wave sensitive	Homo sapiens	42-45
11595757-0	2001	Mutagenesis of the GABA(A) receptor alpha1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine-site ligands.	Benzodiazepines	105-119	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	19-42
11595770-3	2001	The hippocampal formation expresses high levels of alpha subunits with different benzodiazepine binding properties (alpha1, alpha2 and alpha5).	Benzodiazepines	81-95	adrenoceptor alpha 1D	Homo sapiens	116-122
12397859-3	2001	A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.	Benzodiazepines	49-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-173
11495945-3	2001	The other is a novel type of ionotropic GABA receptor that is less sensitive to bicuculline but blocked by the GABA(C) receptor antagonist (1,2,5,6-tetrohydropyridine-4-yl) methylphosphinic acid (TPMPA) and by benzodiazepines.	Benzodiazepines	210-225	GABA type A receptor-associated protein	Homo sapiens	40-53
11495945-3	2001	The other is a novel type of ionotropic GABA receptor that is less sensitive to bicuculline but blocked by the GABA(C) receptor antagonist (1,2,5,6-tetrohydropyridine-4-yl) methylphosphinic acid (TPMPA) and by benzodiazepines.	Benzodiazepines	210-225	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	111-127
11353808-12	2001	We conclude that R1 type compounds act at the benzodiazepine binding site and additionally at a different R1 site, and that the R1, but not the R2 site is allosterically coupled to the benzodiazepine binding site.	Benzodiazepines	46-60	CD1b molecule	Homo sapiens	17-19
11353808-12	2001	We conclude that R1 type compounds act at the benzodiazepine binding site and additionally at a different R1 site, and that the R1, but not the R2 site is allosterically coupled to the benzodiazepine binding site.	Benzodiazepines	185-199	CD1b molecule	Homo sapiens	17-19
11353808-13	2001	ROD178B is a competitive antagonist at the R1 site in that it shows allosteric interaction with the benzodiazepine binding site and displacement of benzodiazepines, and a negative allosteric modulator at the R2 site.	Benzodiazepines	100-114	CD1b molecule	Homo sapiens	43-45
11353808-13	2001	ROD178B is a competitive antagonist at the R1 site in that it shows allosteric interaction with the benzodiazepine binding site and displacement of benzodiazepines, and a negative allosteric modulator at the R2 site.	Benzodiazepines	148-163	CD1b molecule	Homo sapiens	43-45
11353808-4	2001	R1 compounds competitively inhibited binding of benzodiazepines in alpha1beta2gamma2 receptors, and their functional effects were partially inhibited by the benzodiazepine antagonist Ro15-1788 in a noncompetitive manner.	Benzodiazepines	48-62	CD1b molecule	Homo sapiens	0-2
11331142-6	2001	The benzodiazepine alprazolam, also a positive modulator of GABAergic function, similarly decreases CRF mRNA expression in the CeA.	Benzodiazepines	4-18	carcinoembryonic antigen gene family 4	Rattus norvegicus	127-130
11306694-7	2001	Benzodiazepine potentiation at alpha3beta3gamma2s with nonselective agonist chlordiazepoxide was greater than at alpha1, alpha2, or alpha5 (P &lt; 0.001).	Benzodiazepines	0-14	adrenoceptor alpha 1D	Homo sapiens	113-119
11353839-1	2001	Ligands acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABA(A)) receptors currently are the most widely used hypnotics.	Benzodiazepines	22-36	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	50-80
11353839-1	2001	Ligands acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABA(A)) receptors currently are the most widely used hypnotics.	Benzodiazepines	22-36	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	82-89
11353839-1	2001	Ligands acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABA(A)) receptors currently are the most widely used hypnotics.	Benzodiazepines	38-40	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	50-80
11353839-1	2001	Ligands acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABA(A)) receptors currently are the most widely used hypnotics.	Benzodiazepines	38-40	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	82-89
11299307-1	2001	L-655,708 is a ligand for the benzodiazepine site of the gamma-aminobutyric acid type A (GABA(A)) receptor that exhibits a 100-fold higher affinity for alpha5-containing receptors compared with alpha1-containing receptors.	Benzodiazepines	30-44	adrenoceptor alpha 1D	Homo sapiens	194-200
11295439-1	2001	Benzodiazepine (BDZ) is generally thought to bind to site II of human serum albumin (HSA), also known as the indole-BDZ site, which is located at subdomain III A of the molecule.	Benzodiazepines	0-14	albumin	Homo sapiens	70-83
11295439-1	2001	Benzodiazepine (BDZ) is generally thought to bind to site II of human serum albumin (HSA), also known as the indole-BDZ site, which is located at subdomain III A of the molecule.	Benzodiazepines	16-19	albumin	Homo sapiens	70-83
11349394-7	2001	CONCLUSIONS: Our results suggest that the inhibition of melatonin production induced by diazepam in vivo may be due to a direct action of this benzodiazepine on the pineal gland, through its action on NAT, the key enzyme of melatonin synthesis, and that the control of melatonin production in the Harderian glands may be different from that observed in the pineal gland.	Benzodiazepines	143-157	N-acetyltransferase 1	Rattus norvegicus	201-204
11166325-1	2001	Previous studies have suggested that activation of calcium-phospholipid-dependent protein kinase (PKC) enhances benzodiazepine (BZD)- and pentobarbital (PB)- mediated potentiation of alpha(1)beta(1)gamma(2) GABA(A) receptors (GABA(A)-Rs).	Benzodiazepines	112-126	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	207-214
11166325-1	2001	Previous studies have suggested that activation of calcium-phospholipid-dependent protein kinase (PKC) enhances benzodiazepine (BZD)- and pentobarbital (PB)- mediated potentiation of alpha(1)beta(1)gamma(2) GABA(A) receptors (GABA(A)-Rs).	Benzodiazepines	112-126	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	226-233
11166325-1	2001	Previous studies have suggested that activation of calcium-phospholipid-dependent protein kinase (PKC) enhances benzodiazepine (BZD)- and pentobarbital (PB)- mediated potentiation of alpha(1)beta(1)gamma(2) GABA(A) receptors (GABA(A)-Rs).	Benzodiazepines	128-131	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	207-214
11166325-1	2001	Previous studies have suggested that activation of calcium-phospholipid-dependent protein kinase (PKC) enhances benzodiazepine (BZD)- and pentobarbital (PB)- mediated potentiation of alpha(1)beta(1)gamma(2) GABA(A) receptors (GABA(A)-Rs).	Benzodiazepines	128-131	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	226-233
11225506-8	2001	Across varied methodology, data suggest gender-related differences in the metabolism and potentially in the effects and side effects of the various benzodiazepines and antidepressant psychopharmacologic treatments of GAD.	Benzodiazepines	148-163	glutamate decarboxylase 1	Homo sapiens	217-220
11159802-9	2001	Thus, CYP-dependent FNTZ biotransformation, like that of many benzodiazepine derivatives, is mediated mainly by CYP3A.	Benzodiazepines	62-76	peptidylprolyl isomerase G	Homo sapiens	6-9
11159802-9	2001	Thus, CYP-dependent FNTZ biotransformation, like that of many benzodiazepine derivatives, is mediated mainly by CYP3A.	Benzodiazepines	62-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	112-117
11440203-6	2001	In contrast to receptors that contain alpha4 and alpha6 subunits, which are diazepam-insensitive, both BZ(I) and -(II) bind diazepam and other benzodiazepines.	Benzodiazepines	103-105	immunoglobulin binding protein 1	Homo sapiens	38-55
11100148-1	2000	Benzodiazepines (BZs) act on gamma-aminobutyric acid type A (GABAA) receptors such as alpha1beta2gamma2 through key residues within the N-terminal region of alpha subunits, to render their sedative and anxiolytic actions.	Benzodiazepines	0-15	adrenoceptor alpha 1D	Homo sapiens	86-103
11100148-1	2000	Benzodiazepines (BZs) act on gamma-aminobutyric acid type A (GABAA) receptors such as alpha1beta2gamma2 through key residues within the N-terminal region of alpha subunits, to render their sedative and anxiolytic actions.	Benzodiazepines	17-20	adrenoceptor alpha 1D	Homo sapiens	86-103
11117652-2	2000	For the past 4 decades, treatment of insomnia has shifted away from the use of barbiturates toward the use of hypnotic agents of the benzodiazepine class.	Benzodiazepines	133-147	EH domain containing 4	Homo sapiens	8-14
11046107-0	2000	Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric Acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region.	Benzodiazepines	19-33	carbonic anhydrase 1	Rattus norvegicus	183-186
11046107-13	2000	These data indicate that synapses in the hippocampal CA1 region are particularly involved in the adaptive response to chronic benzodiazepine treatments.	Benzodiazepines	126-140	carbonic anhydrase 1	Rattus norvegicus	53-56
11008192-6	2000	Up to now only three classes of drugs have been systematically evaluated for treatment of RLS: benzodiazepines, opioids and dopaminergic agents.The most consistent results have been obtained with dopaminergic drugs.	Benzodiazepines	95-110	RLS1	Homo sapiens	90-93
11164073-1	2000	The possible involvement of an endogenous benzodiazepine (BZ) inverse agonist in the activational effects of corticotrophin-releasing hormone (CRH) on behaviour was examined in pigs given porcine CRH (75 microg) intracerebroventricularly (i.c.v.)	Benzodiazepines	42-56	corticotropin releasing hormone	Sus scrofa	109-141
11164073-1	2000	The possible involvement of an endogenous benzodiazepine (BZ) inverse agonist in the activational effects of corticotrophin-releasing hormone (CRH) on behaviour was examined in pigs given porcine CRH (75 microg) intracerebroventricularly (i.c.v.)	Benzodiazepines	42-56	corticotropin releasing hormone	Sus scrofa	143-146
11164073-1	2000	The possible involvement of an endogenous benzodiazepine (BZ) inverse agonist in the activational effects of corticotrophin-releasing hormone (CRH) on behaviour was examined in pigs given porcine CRH (75 microg) intracerebroventricularly (i.c.v.)	Benzodiazepines	58-60	corticotropin releasing hormone	Sus scrofa	109-141
11164073-1	2000	The possible involvement of an endogenous benzodiazepine (BZ) inverse agonist in the activational effects of corticotrophin-releasing hormone (CRH) on behaviour was examined in pigs given porcine CRH (75 microg) intracerebroventricularly (i.c.v.)	Benzodiazepines	58-60	corticotropin releasing hormone	Sus scrofa	143-146
11164091-8	2000	Taken together, these results suggest that this analog of honokiol acts at the benzodiazepine recognition site of the GABA(A)-benzodiazepine receptor complex.	Benzodiazepines	79-93	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	118-125
11057525-8	2000	Subsequent testing with DMCM confirmed that a benzodiazepine inverse agonist can induce Fos-LI in most of the same brain regions as observed following ethanol withdrawal, and that this change in Fos protein can be attenuated by pretreatment with flumazenil (5.0 mg/kg).	Benzodiazepines	46-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-91
11057525-8	2000	Subsequent testing with DMCM confirmed that a benzodiazepine inverse agonist can induce Fos-LI in most of the same brain regions as observed following ethanol withdrawal, and that this change in Fos protein can be attenuated by pretreatment with flumazenil (5.0 mg/kg).	Benzodiazepines	46-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	195-198
10884565-1	2000	Compounds varying in selectivity as 5-HT(1A) receptor antagonists have recently been reported to produce benzodiazepine-like antianxiety effects in mice.	Benzodiazepines	105-119	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	36-53
10905782-10	2000	Pharmacologic treatment of RLS includes dopaminergic agents, opioids, benzodiazepines and anticonvulsants.	Benzodiazepines	70-85	RLS1	Homo sapiens	27-30
10947838-1	2000	The gamma2 subunit is an important functional determinant of GABAA receptors and is essential for formation of high-affinity benzodiazepine binding sites and for synaptic clustering of major GABAA receptor subtypes along with gephyrin.	Benzodiazepines	125-139	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	4-10
10947838-1	2000	The gamma2 subunit is an important functional determinant of GABAA receptors and is essential for formation of high-affinity benzodiazepine binding sites and for synaptic clustering of major GABAA receptor subtypes along with gephyrin.	Benzodiazepines	125-139	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	61-66
10856895-1	2000	Peripheral benzodiazepine (BDZ) receptor (PBR) and diazepam-binding inhibitor/acyl-CoA-binding protein (DBI/ACBP) characterized as a ligand at central BDZ receptors, at PBR with involvement in the regulation of steroidogenesis, and as an intracellular acyl-CoA transporter, are both known to interact with BDZ in adult systems.	Benzodiazepines	27-30	translocator protein	Rattus norvegicus	42-45
10856895-1	2000	Peripheral benzodiazepine (BDZ) receptor (PBR) and diazepam-binding inhibitor/acyl-CoA-binding protein (DBI/ACBP) characterized as a ligand at central BDZ receptors, at PBR with involvement in the regulation of steroidogenesis, and as an intracellular acyl-CoA transporter, are both known to interact with BDZ in adult systems.	Benzodiazepines	27-30	translocator protein	Rattus norvegicus	169-172
10861014-1	2000	Two distinct benzodiazepine binding sites have been identified, (i) a central site restricted to brain and (ii) a ubiquitously expressed mitochondrial binding site, the so-called peripheral-type benzodiazepine receptor (PBR).	Benzodiazepines	13-27	translocator protein	Homo sapiens	179-218
11104938-12	2000	For example, the prescription of HDB at a daily dose of less than 6.2mg was associated with a higher rate of benzodiazepine use; and prescription of several daily doses of HDB was associated with a higher percentage of injecting patients.	Benzodiazepines	109-123	integrator complex subunit 6	Homo sapiens	33-36
10959491-0	2000	New benzodiazepines alter acetylcholinesterase and ATPDase activities.	Benzodiazepines	4-19	acetylcholinesterase	Rattus norvegicus	26-46
10959491-0	2000	New benzodiazepines alter acetylcholinesterase and ATPDase activities.	Benzodiazepines	4-19	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	51-58
10959491-7	2000	Our results suggest that, although diazepam and the new benzodiazepines have chemical differences, they both presented an inhibitory effect on acetylcholinesterase and ATPDase activities.	Benzodiazepines	56-71	acetylcholinesterase	Rattus norvegicus	143-163
10959491-7	2000	Our results suggest that, although diazepam and the new benzodiazepines have chemical differences, they both presented an inhibitory effect on acetylcholinesterase and ATPDase activities.	Benzodiazepines	56-71	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	168-175
10854572-0	2000	Role of bicarbonate ion in mediating decreased synaptic conductance in benzodiazepine tolerant hippocampal CA1 pyramidal neurons.	Benzodiazepines	71-85	carbonic anhydrase 1	Rattus norvegicus	107-110
10861014-1	2000	Two distinct benzodiazepine binding sites have been identified, (i) a central site restricted to brain and (ii) a ubiquitously expressed mitochondrial binding site, the so-called peripheral-type benzodiazepine receptor (PBR).	Benzodiazepines	13-27	translocator protein	Homo sapiens	220-223
10888318-9	2000	These measurements detect binding to the warfarin and benzodiazepine binding sites of human serum albumin.	Benzodiazepines	54-68	albumin	Homo sapiens	92-105
10882360-2	2000	To date, three general classes of CCK-A agonists have been reported, the full-length, sulfated hepta- and hexapeptides, a series of tetrapeptides, and most recently a series of benzodiazepines.	Benzodiazepines	177-192	cholecystokinin A receptor	Homo sapiens	34-39
10843459-5	2000	However, for the thienobenzodiazepine olanzapine a main metabolic route is direct conjugation at the benzodiazepine nucleus, whereas for the dibenzothiazepine quetiapine and the dibenzothiepine zotepine it is CYP3A4-mediated oxidation, leading to sulfoxidation, hydroxylation and dealkylation for quetiapine, but N-demethylation to the active nor-derivative for zotepine.	Benzodiazepines	23-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	209-215
10858841-9	2000	However, clinically relevant concentrations of both benzodiazepines significantly enhanced beta-glucuronidase activity.	Benzodiazepines	52-67	glucuronidase beta	Homo sapiens	91-109
10720275-10	2000	RLS-positive individuals took more benzodiazepines and estrogen compared with non-RLS cases, but the differences were not statistically significant.	Benzodiazepines	35-50	RLS1	Homo sapiens	0-3
10751426-7	2000	These data suggest a pathological pathway, initiated by a 5-HT(1A) receptor deficit, leading to abnormalities in GABA(A) receptor composition and level, which in turn result in BZ-insensitivity and anxiety.	Benzodiazepines	177-179	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	58-75
11218808-11	2000	The above observations suggest that in epilepsy, L-deprenyl might be acting partially by influencing the GABAA/benzodiazepine mechanism in the brain (similar to diazepam and phenytoin), and in cognition enhancing effect, the cholinergic system might be playing a role.	Benzodiazepines	111-125	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	105-110
10727623-8	2000	The results reveal differential regulation of EGR-1 by diazepam in the central and lateral nuclei of the amygdala suggesting that these two amygdala nuclei act in a reciprocal manner during the anxiolytic and amnesic action of the benzodiazepine agonist.	Benzodiazepines	231-245	early growth response 1	Rattus norvegicus	46-51
10724170-5	2000	In mice of all ages lacking an isoform of GABA (gamma-aminobutyric acid) synthetic enzyme (GAD65), as well as in immature wild-type animals before the onset of their natural critical period, benzodiazepines selectively reduced a prolonged discharge phenotype to unmask plasticity.	Benzodiazepines	191-206	glutamic acid decarboxylase 2	Mus musculus	91-96
10755464-3	2000	Since buprenorphine and many benzodiazepines are CYP3A substrates, the effect of buprenorphine on CYP3A activity was examined in order to assess the likelihood of a pharmacokinetic interaction.	Benzodiazepines	29-44	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-54