PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27399668-5	2016	Gingerol significantly enhanced the cytotoxic profile of doxorubicin against HepG2 and Huh7, cells decreasing its IC50s by 10- and 4-fold, respectively.	gingerol	0-8	MIR7-3 host gene	Homo sapiens	87-91
27606946-6	2016	In addition, in silico docking simulation and a subsequent mutational study suggested that [6]-gingerol might bind to and activate TRPV1 in a unique manner.	gingerol	91-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	131-136
27645308-0	2016	Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3beta and beta-catenin pathway in A549 cell line.	gingerol	24-34	prostaglandin E synthase	Mus musculus	62-69
27451028-8	2016	It has been demonstrated that 6-gingerol suppressed the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, increased the expression of Beclin1 to promote autophagy, and increased Bcl-2 expression to inhibit apoptosis.	gingerol	30-40	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	56-85
27451028-8	2016	It has been demonstrated that 6-gingerol suppressed the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, increased the expression of Beclin1 to promote autophagy, and increased Bcl-2 expression to inhibit apoptosis.	gingerol	30-40	AKT serine/threonine kinase 1	Homo sapiens	93-96
27451028-8	2016	It has been demonstrated that 6-gingerol suppressed the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, increased the expression of Beclin1 to promote autophagy, and increased Bcl-2 expression to inhibit apoptosis.	gingerol	30-40	mechanistic target of rapamycin kinase	Homo sapiens	97-101
27451028-8	2016	It has been demonstrated that 6-gingerol suppressed the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, increased the expression of Beclin1 to promote autophagy, and increased Bcl-2 expression to inhibit apoptosis.	gingerol	30-40	beclin 1	Homo sapiens	149-156
27451028-8	2016	It has been demonstrated that 6-gingerol suppressed the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, increased the expression of Beclin1 to promote autophagy, and increased Bcl-2 expression to inhibit apoptosis.	gingerol	30-40	BCL2 apoptosis regulator	Homo sapiens	193-198
27493480-0	2016	Effect of Gingerol on Cisplatin-Induced Pica Analogous to Emesis Via Modulating Expressions of Dopamine 2 Receptor, Dopamine Transporter and Tyrosine Hydroxylase in the Vomiting Model of Rats.	gingerol	10-18	solute carrier family 6 member 3	Rattus norvegicus	116-136
27493480-14	2016	Gingerol markedly improved gastric emptying induced by cisplatin in a dose-dependent manner (P < 0.05), and exhibited effective dose-dependent inhibition on the increase of expression levels of D2R and TH and the decrease of expression levels of DAT in both the ileum and area postrema (P < 0.05).	gingerol	0-8	solute carrier family 6 member 3	Rattus norvegicus	249-252
27493480-15	2016	CONCLUSION: Gingerol is effective on cisplatin-induced emesis in rats possibly by inhibiting central or peripheral increase of DA by inhibiting D2R, TH and accelerating DAT.	gingerol	12-20	solute carrier family 6 member 3	Rattus norvegicus	169-172
26809353-6	2016	Gin significantly ameliorated the increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, albumin, total cholesterol (TC) and triglyceride (TG) concentrations, and liver index.	gingerol	0-3	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	87-113
26809353-6	2016	Gin significantly ameliorated the increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, albumin, total cholesterol (TC) and triglyceride (TG) concentrations, and liver index.	gingerol	0-3	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	115-118
26809353-9	2016	Further, Gin administration hampered alpha-smooth muscle actin (alpha-SMA) expression and significantly reduced hepatic content of transforming growth factor-beta (TGF-beta).	gingerol	9-12	actin gamma 2, smooth muscle	Rattus norvegicus	37-62
26809353-9	2016	Further, Gin administration hampered alpha-smooth muscle actin (alpha-SMA) expression and significantly reduced hepatic content of transforming growth factor-beta (TGF-beta).	gingerol	9-12	actin gamma 2, smooth muscle	Rattus norvegicus	64-73
26554741-0	2016	10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity.	gingerol	0-11	AKT serine/threonine kinase 1	Homo sapiens	105-108
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	15-18	nitric oxide synthase 2	Rattus norvegicus	90-121
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	15-18	nitric oxide synthase 2	Rattus norvegicus	123-127
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	15-18	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	133-149
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	15-18	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	151-156
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	192-195	nitric oxide synthase 2	Rattus norvegicus	90-121
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	192-195	nitric oxide synthase 2	Rattus norvegicus	123-127
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	192-195	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	133-149
26809353-12	2016	Involvement of Gin anti-inflammatory activity was verified by the decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in livers of animals treated with Gin.	gingerol	192-195	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	151-156
26809353-13	2016	Thus, it can be concluded that Gin protects against CCl4-induced liver fibrosis in rats.	gingerol	31-34	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
26240073-0	2016	Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation.	gingerol	0-8	mitogen activated protein kinase 14	Rattus norvegicus	131-134
26240073-5	2016	The FBS-induced proliferating cell nuclear antigen (PCNA) upregulation and p27(Kip1) downregulation were also attenuated in gingerol (200 mumol/L) pretreated cells.	gingerol	124-132	proliferating cell nuclear antigen	Rattus norvegicus	16-50
26240073-5	2016	The FBS-induced proliferating cell nuclear antigen (PCNA) upregulation and p27(Kip1) downregulation were also attenuated in gingerol (200 mumol/L) pretreated cells.	gingerol	124-132	proliferating cell nuclear antigen	Rattus norvegicus	52-56
26240073-5	2016	The FBS-induced proliferating cell nuclear antigen (PCNA) upregulation and p27(Kip1) downregulation were also attenuated in gingerol (200 mumol/L) pretreated cells.	gingerol	124-132	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	75-78
26240073-5	2016	The FBS-induced proliferating cell nuclear antigen (PCNA) upregulation and p27(Kip1) downregulation were also attenuated in gingerol (200 mumol/L) pretreated cells.	gingerol	124-132	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	79-83
26240073-6	2016	Fetal bovine serum-induced p38 mitogen-activated protein kinase (MAPK) activation, PCNA upregulation, and p27(Kip1) downregulation were abrogated in gingerol (200 mumol/L) and p38 MAPK inhibitor (SB203580, 10 mumol/L) pretreated cells.	gingerol	149-157	mitogen activated protein kinase 14	Rattus norvegicus	27-30
26240073-6	2016	Fetal bovine serum-induced p38 mitogen-activated protein kinase (MAPK) activation, PCNA upregulation, and p27(Kip1) downregulation were abrogated in gingerol (200 mumol/L) and p38 MAPK inhibitor (SB203580, 10 mumol/L) pretreated cells.	gingerol	149-157	proliferating cell nuclear antigen	Rattus norvegicus	83-87
26240073-6	2016	Fetal bovine serum-induced p38 mitogen-activated protein kinase (MAPK) activation, PCNA upregulation, and p27(Kip1) downregulation were abrogated in gingerol (200 mumol/L) and p38 MAPK inhibitor (SB203580, 10 mumol/L) pretreated cells.	gingerol	149-157	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	106-109
26240073-6	2016	Fetal bovine serum-induced p38 mitogen-activated protein kinase (MAPK) activation, PCNA upregulation, and p27(Kip1) downregulation were abrogated in gingerol (200 mumol/L) and p38 MAPK inhibitor (SB203580, 10 mumol/L) pretreated cells.	gingerol	149-157	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	110-114
26240073-6	2016	Fetal bovine serum-induced p38 mitogen-activated protein kinase (MAPK) activation, PCNA upregulation, and p27(Kip1) downregulation were abrogated in gingerol (200 mumol/L) and p38 MAPK inhibitor (SB203580, 10 mumol/L) pretreated cells.	gingerol	149-157	mitogen activated protein kinase 14	Rattus norvegicus	176-179
26240073-8	2016	Pretreatment with gingerol (200 mumol/L) significantly attenuated injury-induced p38 MAPK activation, PCNA upregulation, and p27(Kip1) downregulation.	gingerol	18-26	mitogen activated protein kinase 14	Rattus norvegicus	81-84
26240073-8	2016	Pretreatment with gingerol (200 mumol/L) significantly attenuated injury-induced p38 MAPK activation, PCNA upregulation, and p27(Kip1) downregulation.	gingerol	18-26	proliferating cell nuclear antigen	Rattus norvegicus	102-106
26240073-8	2016	Pretreatment with gingerol (200 mumol/L) significantly attenuated injury-induced p38 MAPK activation, PCNA upregulation, and p27(Kip1) downregulation.	gingerol	18-26	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	125-128
26240073-8	2016	Pretreatment with gingerol (200 mumol/L) significantly attenuated injury-induced p38 MAPK activation, PCNA upregulation, and p27(Kip1) downregulation.	gingerol	18-26	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	129-133
26240073-11	2016	CONCLUSION: Gingerol prevented FBS-induced VSMC proliferation and balloon injury-induced neointima formation by regulating p38 MAPK.	gingerol	12-20	mitogen activated protein kinase 14	Rattus norvegicus	123-126
26554741-4	2016	These antitumor activities of 10-gingerol were mediated through inactivation of Akt and p38MAPK activity, and suppression of epidermal growth factor receptor expression.	gingerol	30-41	epidermal growth factor receptor	Homo sapiens	125-157
26544119-4	2016	Kinetic parameters of SULT1A1, SULT1A3, SULT1C4, and SULT1E1 that showed stronger 6-gingerol-sulfating activity were determined.	gingerol	82-92	sulfotransferase family 1A member 1	Homo sapiens	22-29
26544119-4	2016	Kinetic parameters of SULT1A1, SULT1A3, SULT1C4, and SULT1E1 that showed stronger 6-gingerol-sulfating activity were determined.	gingerol	82-92	sulfotransferase family 1A member 3	Homo sapiens	31-38
26749462-2	2016	In this study, we evaluated antitumor activities of 6-gingerol on human oral (SCC4, KB) and cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin.	gingerol	52-62	MAU2 sister chromatid cohesion factor	Homo sapiens	78-82
26749462-6	2016	Treatment with 6-gingerol resulted in G2-phase arrest in KB and HeLa cells and S-phase arrest in SCC4 cells.	gingerol	15-25	MAU2 sister chromatid cohesion factor	Homo sapiens	97-101
26749462-7	2016	6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of caspase 3 in all cell lines.	gingerol	0-10	caspase 3	Homo sapiens	92-101
26939769-4	2016	Incubation of activated human T lymphocytes with gingerols increased the intracellular Ca(2+) concentration as well as the IFN-gamma secretion by about 20-30%.	gingerol	49-58	interferon gamma	Homo sapiens	123-132
26939769-5	2016	This gingerol-induced increase of IFN-gamma secretion could be blocked by the specific TRPV1 antagonist SB-366791.	gingerol	5-13	interferon gamma	Homo sapiens	34-43
26939769-5	2016	This gingerol-induced increase of IFN-gamma secretion could be blocked by the specific TRPV1 antagonist SB-366791.	gingerol	5-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
26939769-6	2016	The results of the present study point to an interaction of gingerols with TRPV1 in activated T lymphocytes leading to an augmentation of IFN-gamma secretion.	gingerol	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
26939769-6	2016	The results of the present study point to an interaction of gingerols with TRPV1 in activated T lymphocytes leading to an augmentation of IFN-gamma secretion.	gingerol	60-69	interferon gamma	Homo sapiens	138-147
26544119-4	2016	Kinetic parameters of SULT1A1, SULT1A3, SULT1C4, and SULT1E1 that showed stronger 6-gingerol-sulfating activity were determined.	gingerol	82-92	sulfotransferase family 1C member 4	Homo sapiens	40-47
26554741-4	2016	These antitumor activities of 10-gingerol were mediated through inactivation of Akt and p38MAPK activity, and suppression of epidermal growth factor receptor expression.	gingerol	30-41	AKT serine/threonine kinase 1	Homo sapiens	80-83
26178781-4	2015	In contrast, only [8]-gingerol and [10]-gingerol inhibited CD25 and CD69 expression, and IL-2 synthesis.	gingerol	20-30	interleukin 2 receptor, alpha chain	Mus musculus	59-63
26544119-4	2016	Kinetic parameters of SULT1A1, SULT1A3, SULT1C4, and SULT1E1 that showed stronger 6-gingerol-sulfating activity were determined.	gingerol	82-92	sulfotransferase family 1E member 1	Homo sapiens	53-60
26498061-0	2015	Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/beta-catenin signaling pathway in 3T3-L1 adipocytes.	gingerol	18-28	catenin (cadherin associated protein), beta 1	Mus musculus	75-87
26498061-5	2015	The extent of suppression of differentiation by 6-gingerol was characterized by measuring the triglyceride content and GPDH activity.	gingerol	48-58	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	119-123
26498061-8	2015	Small interfering RNA transfection was conducted to elucidate the crucial role of beta-catenin in anti-adipogenic effect of 6-gingerol.	gingerol	124-134	catenin (cadherin associated protein), beta 1	Mus musculus	82-94
26498061-10	2015	The effect of 6-gingerol on adipogenic differentiation was accompanied by stimulating the activation of the Wnt/beta-catenin signaling.	gingerol	14-24	catenin (cadherin associated protein), beta 1	Mus musculus	112-124
26498061-11	2015	In addition, we found that 6-gingerol induced phosphorylations of glycogen synthase kinase-3beta(GSK-3beta), and promoted the nuclear accumulation of beta-catenin.	gingerol	27-37	glycogen synthase kinase 3 beta	Mus musculus	66-96
26498061-11	2015	In addition, we found that 6-gingerol induced phosphorylations of glycogen synthase kinase-3beta(GSK-3beta), and promoted the nuclear accumulation of beta-catenin.	gingerol	27-37	glycogen synthase kinase 3 beta	Mus musculus	97-106
26498061-11	2015	In addition, we found that 6-gingerol induced phosphorylations of glycogen synthase kinase-3beta(GSK-3beta), and promoted the nuclear accumulation of beta-catenin.	gingerol	27-37	catenin (cadherin associated protein), beta 1	Mus musculus	150-162
26498061-12	2015	Importantly, the inhibitory effect of 6-gingerol on adipogenic differentiation was reversed after the siRNA knockdown of beta-catenin was added.	gingerol	38-48	catenin (cadherin associated protein), beta 1	Mus musculus	121-133
26498061-13	2015	Our findings demonstrated that 6-gingerol inhibits the adipogenic differentiation of 3T3-L1 cells through activating the Wnt/beta-catenin signaling pathway.	gingerol	31-41	catenin (cadherin associated protein), beta 1	Mus musculus	125-137
26178781-6	2015	Exogenous IL-2 enhanced T lymphocyte proliferation in the presence of [6]-gingerol but did not significantly increase T lymphocyte proliferation in the presence of [8]-gingerol or [10]-gingerol.	gingerol	70-82	interleukin 2	Mus musculus	10-14
26178781-6	2015	Exogenous IL-2 enhanced T lymphocyte proliferation in the presence of [6]-gingerol but did not significantly increase T lymphocyte proliferation in the presence of [8]-gingerol or [10]-gingerol.	gingerol	72-82	interleukin 2	Mus musculus	10-14
26178781-7	2015	In line with this finding, [8]-gingerol and [10]-gingerol impaired IL-2-induced proliferation of CTLL-2 cells, but constitutive CD25 expression was unaffected, indicating inhibition of IL-2 receptor signaling.	gingerol	31-39	interleukin 2	Mus musculus	67-71
26178781-7	2015	In line with this finding, [8]-gingerol and [10]-gingerol impaired IL-2-induced proliferation of CTLL-2 cells, but constitutive CD25 expression was unaffected, indicating inhibition of IL-2 receptor signaling.	gingerol	31-39	interleukin 2	Mus musculus	185-189
26178781-4	2015	In contrast, only [8]-gingerol and [10]-gingerol inhibited CD25 and CD69 expression, and IL-2 synthesis.	gingerol	20-30	CD69 antigen	Mus musculus	68-72
26178781-4	2015	In contrast, only [8]-gingerol and [10]-gingerol inhibited CD25 and CD69 expression, and IL-2 synthesis.	gingerol	20-30	interleukin 2	Mus musculus	89-93
26101135-8	2015	6-Shogaol and 6-gingerol acted as specific PPARdelta ligands and stimulated PPARdelta-dependent gene expression in cultured human skeletal muscle myotubes.	gingerol	14-24	peroxisome proliferator activated receptor delta	Homo sapiens	43-52
26101135-8	2015	6-Shogaol and 6-gingerol acted as specific PPARdelta ligands and stimulated PPARdelta-dependent gene expression in cultured human skeletal muscle myotubes.	gingerol	14-24	peroxisome proliferator activated receptor delta	Homo sapiens	76-85
26101135-11	2015	6-Shogaol and 6-gingerol may be responsible for the regulatory effects of dietary ginger on PPARdelta signaling.	gingerol	14-24	peroxisome proliferator activated receptor delta	Homo sapiens	92-101
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
24962868-7	2015	Compared with other analogues of 6SG, such as 6-gingerol (6G), 8-gingerol (8G), and 10-gingerol (10G), 6SG was found to be the most potent blocker of STAT3 activation.	gingerol	84-95	signal transducer and activator of transcription 3	Homo sapiens	150-155
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	gingerol	13-23	interleukin 1 beta	Mus musculus	89-97
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	gingerol	13-23	tumor necrosis factor	Mus musculus	99-107
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	glycogen synthase kinase 3 beta	Rattus norvegicus	118-148
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	glycogen synthase kinase 3 beta	Rattus norvegicus	152-161
25811848-7	2015	Overall, these results indicate that 6-gingerol exhibited protective effects on apoptosis induced by Abeta1-42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3beta and enhancing the activation of Akt, thereby exerting neuroprotective effects.	gingerol	37-47	glycogen synthase kinase 3 beta	Rattus norvegicus	221-230
25811848-7	2015	Overall, these results indicate that 6-gingerol exhibited protective effects on apoptosis induced by Abeta1-42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3beta and enhancing the activation of Akt, thereby exerting neuroprotective effects.	gingerol	37-47	AKT serine/threonine kinase 1	Rattus norvegicus	263-266
24794903-7	2015	Promotion by [6]-gingerol of glucose transporter 4 (GLUT4) translocation to plasma membrane was visually demonstrated by immunocytochemistry in L6 myoblasts transfected with glut4 cDNA-coding vector.	gingerol	13-25	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	29-50
25864108-7	2015	Results indicated that treatments of IOMM-Lee and CH157MN meningioma cells with Limonin, Tangeritin, Zerumbone, 6-Gingerol, Ganoderic Acid A, and Ganoderic Acid DM induced apoptosis with enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) via inhibition of the Wnt5/beta-catenin pathway.	gingerol	112-122	glycogen synthase kinase 3 beta	Homo sapiens	215-246
25864108-7	2015	Results indicated that treatments of IOMM-Lee and CH157MN meningioma cells with Limonin, Tangeritin, Zerumbone, 6-Gingerol, Ganoderic Acid A, and Ganoderic Acid DM induced apoptosis with enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) via inhibition of the Wnt5/beta-catenin pathway.	gingerol	112-122	glycogen synthase kinase 3 beta	Homo sapiens	248-256
25864108-7	2015	Results indicated that treatments of IOMM-Lee and CH157MN meningioma cells with Limonin, Tangeritin, Zerumbone, 6-Gingerol, Ganoderic Acid A, and Ganoderic Acid DM induced apoptosis with enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) via inhibition of the Wnt5/beta-catenin pathway.	gingerol	112-122	catenin beta 1	Homo sapiens	285-297
26033206-0	2015	Paradoxical effects of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) activator gingerol on NG115-401L neuronal cells: failure to augment ER Ca(2+) uptake and protect against ER stress-induced cell death.	gingerol	83-91	ATPase, Ca++ transporting, ubiquitous	Mus musculus	66-71
26033206-3	2015	We report that the SERCA activator gingerol stimulates SR microsomal Ca(2+)-ATPase activity and restores enzymatic function in the presence of potent SERCA blockers.	gingerol	35-43	ATPase, Ca++ transporting, ubiquitous	Mus musculus	19-24
26033206-3	2015	We report that the SERCA activator gingerol stimulates SR microsomal Ca(2+)-ATPase activity and restores enzymatic function in the presence of potent SERCA blockers.	gingerol	35-43	ATPase, Ca++ transporting, ubiquitous	Mus musculus	150-155
24794903-7	2015	Promotion by [6]-gingerol of glucose transporter 4 (GLUT4) translocation to plasma membrane was visually demonstrated by immunocytochemistry in L6 myoblasts transfected with glut4 cDNA-coding vector.	gingerol	13-25	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	52-57
24794903-7	2015	Promotion by [6]-gingerol of glucose transporter 4 (GLUT4) translocation to plasma membrane was visually demonstrated by immunocytochemistry in L6 myoblasts transfected with glut4 cDNA-coding vector.	gingerol	13-25	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	174-179
25694332-3	2015	Stimulation of glucose uptake by [6]-gingerol was dependent on AMPKalpha2.	gingerol	33-45	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	63-73
25923459-6	2015	6-Gingerol induced the differentiation of osteoblast-like cells with increased transcription levels of osteogenic markers, upregulated ALP enzyme activity, and enhanced mineralized nodule formation.	gingerol	0-10	alkaline phosphatase, placental	Homo sapiens	135-138
25923459-8	2015	6-Gingerol reduced the degree of inflammation in TNF-alpha-treated MG-63 cells.	gingerol	0-10	tumor necrosis factor	Homo sapiens	49-58
25694332-0	2015	[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKalpha2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.	gingerol	4-12	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	67-77
25694332-4	2015	Moreover, both Inhibition and knockdown of AMPKalpha2 blocked [6]-gingerol-induced glucose uptake.	gingerol	62-74	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	43-53
25694332-5	2015	[6]-Gingerol significantly decreased the activity of protein phosphatase 2A (PP2A).	gingerol	0-12	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	77-81
25694332-0	2015	[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKalpha2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.	gingerol	4-12	TBC1 domain family, member 4	Mus musculus	87-92
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	71-83	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	34-44
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	71-83	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	49-53
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	71-83	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	101-105
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	129-141	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	34-44
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	129-141	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	49-53
25694332-7	2015	Moreover, the interaction between AMPKalpha2 and PP2A was increased by [6]-gingerol, suggesting that PP2A mediates the effect of [6]-gingerol on AMPK phosphorylation.	gingerol	129-141	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	101-105
25694332-8	2015	In addition, [6]-gingerol increased the phosphorylation of Akt-substrate 160 (AS160), which is a Rab GTPase-activating protein.	gingerol	13-25	TBC1 domain family, member 4	Mus musculus	59-76
25694332-8	2015	In addition, [6]-gingerol increased the phosphorylation of Akt-substrate 160 (AS160), which is a Rab GTPase-activating protein.	gingerol	13-25	TBC1 domain family, member 4	Mus musculus	78-83
25694332-9	2015	Inhibition of AMPKalpha2 blocked [6]-gingerol-induced AS160 phosphorylation.	gingerol	37-45	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	14-24
25694332-9	2015	Inhibition of AMPKalpha2 blocked [6]-gingerol-induced AS160 phosphorylation.	gingerol	37-45	TBC1 domain family, member 4	Mus musculus	54-59
25694332-13	2015	This potentiation was not observed in the presence of AMPK inhibitor compound C. In summary, our results suggest that [6]-gingerol plays an important role in glucose metabolism via the AMPKalpha2-mediated AS160-Rab5 pathway and through potentiation of insulin-mediated glucose regulation.	gingerol	118-130	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	185-195
25694332-13	2015	This potentiation was not observed in the presence of AMPK inhibitor compound C. In summary, our results suggest that [6]-gingerol plays an important role in glucose metabolism via the AMPKalpha2-mediated AS160-Rab5 pathway and through potentiation of insulin-mediated glucose regulation.	gingerol	118-130	TBC1 domain family, member 4	Mus musculus	205-210
25496264-0	2015	Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.	gingerol	34-43	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	84-111
25925967-6	2015	The expression of inflammatory cytokine genes and nuclear transcription factor-kappaB (NF-kappaB) were increased in the HFD group; these effects were attenuated by [6]-gingerol.	gingerol	164-176	nuclear factor kappa B subunit 1	Homo sapiens	50-85
25925967-6	2015	The expression of inflammatory cytokine genes and nuclear transcription factor-kappaB (NF-kappaB) were increased in the HFD group; these effects were attenuated by [6]-gingerol.	gingerol	164-176	nuclear factor kappa B subunit 1	Homo sapiens	87-96
25925967-8	2015	[6]-Gingerol may attenuate HFD-induced steatohepatitis by downregulating NF-kappaB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.	gingerol	0-12	nuclear factor kappa B subunit 1	Homo sapiens	73-82
25813697-0	2015	Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death.	gingerol	36-44	TNF superfamily member 10	Homo sapiens	54-59
25813697-6	2015	In the present study, we showed that treatment with TRAIL slightly induced cell death, but gingerol treatment enhanced the TRAIL-induced cell death in human lung cancer cells.	gingerol	91-99	TNF superfamily member 10	Homo sapiens	123-128
25813697-7	2015	The combination of gingerol and TRAIL increased accumulation of microtubule-associated protein light chain 3-II and p62, confirming the inhibited autophagy flux.	gingerol	19-27	nucleoporin 62	Homo sapiens	116-119
25813697-8	2015	Collectively, our results suggest that gingerol sensitizes human lung cancer cells to TRAIL-induced apoptosis by inhibiting the autophagy flux.	gingerol	39-47	TNF superfamily member 10	Homo sapiens	86-91
25496264-0	2015	Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.	gingerol	34-43	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	177-183
25496264-0	2015	Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.	gingerol	34-43	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	188-194
25496264-1	2015	OBJECTIVES: To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and to identify the main UGT enzymes involved in regioselective glucuronidation of gingerols.	gingerol	85-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	165-192
25496264-1	2015	OBJECTIVES: To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and to identify the main UGT enzymes involved in regioselective glucuronidation of gingerols.	gingerol	85-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	194-197
25496264-1	2015	OBJECTIVES: To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and to identify the main UGT enzymes involved in regioselective glucuronidation of gingerols.	gingerol	85-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	233-236
25496264-4	2015	Activity correlation analyses were performed to identify the main UGT enzymes contributing to hepatic metabolism of gingerols.	gingerol	116-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	66-69
25496264-7	2015	UGT1A8 (an intestinal enzyme), UGT1A9 and UGT2B7 were the enzymes showing the highest activity towards gingerols.	gingerol	103-112	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	0-6
25496264-7	2015	UGT1A8 (an intestinal enzyme), UGT1A9 and UGT2B7 were the enzymes showing the highest activity towards gingerols.	gingerol	103-112	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	31-37
25496264-7	2015	UGT1A8 (an intestinal enzyme), UGT1A9 and UGT2B7 were the enzymes showing the highest activity towards gingerols.	gingerol	103-112	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	42-48
25496264-10	2015	Further, activity correlation analyses indicated that UGT2B7 and UGT1A9 were primarily responsible for 4"-O-glucuronidation and 5-O-glucuronidation of gingerols in the liver, respectively.	gingerol	151-160	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	54-60
25496264-10	2015	Further, activity correlation analyses indicated that UGT2B7 and UGT1A9 were primarily responsible for 4"-O-glucuronidation and 5-O-glucuronidation of gingerols in the liver, respectively.	gingerol	151-160	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	65-71
25496264-11	2015	CONCLUSIONS: Gingerols were metabolized by multiple hepatic and gastrointestinal UGT enzymes.	gingerol	13-22	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	81-84
25496264-12	2015	Also, UGT1A9 and 2B7 were the main contributors to regioselective glucuronidation of gingerols in the liver.	gingerol	85-94	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	6-12
25631463-6	2015	Moreover, 6-gingerol significantly suppressed the circulating concentrations of interleukin-1beta and tumor necrosis factor alpha and restored the colonic nitric oxide concentration and myeloperoxidase activity to normal in DSS-treated mice.	gingerol	10-20	interleukin 1 beta	Mus musculus	80-129
25631463-6	2015	Moreover, 6-gingerol significantly suppressed the circulating concentrations of interleukin-1beta and tumor necrosis factor alpha and restored the colonic nitric oxide concentration and myeloperoxidase activity to normal in DSS-treated mice.	gingerol	10-20	myeloperoxidase	Mus musculus	186-201
25686711-3	2015	The results showed that 6-G, 6-S, and PTE selectively killed BCSCs and had high sensitivity for BCSCs isolated from MCF-7 cells that expressed the surface antigen CD44(+)/CD24(-).	gingerol	24-27	CD44 molecule (Indian blood group)	Homo sapiens	163-167
26101700-4	2015	[6]-gingerol administration manifested inhibition of FASN expression, indicating FASN is a major target of [6]-gingerol inducing apoptosis in HepG2 cells.	gingerol	3-12	fatty acid synthase	Homo sapiens	53-57
26101700-4	2015	[6]-gingerol administration manifested inhibition of FASN expression, indicating FASN is a major target of [6]-gingerol inducing apoptosis in HepG2 cells.	gingerol	0-12	fatty acid synthase	Homo sapiens	53-57
25686711-3	2015	The results showed that 6-G, 6-S, and PTE selectively killed BCSCs and had high sensitivity for BCSCs isolated from MCF-7 cells that expressed the surface antigen CD44(+)/CD24(-).	gingerol	24-27	CD24 molecule	Homo sapiens	171-175
25658238-7	2015	The expressions of inflammatory cytokine genes, including those for monocyte chemoattractant protein-1, tumor necrosis factor-alpha, and interleukin-6, and nuclear transcription factor (NF-kappaB), which were increased in the livers of MCD diet-fed mice, were attenuated by 6-gingerol.	gingerol	274-284	chemokine (C-C motif) ligand 2	Mus musculus	68-131
25658238-8	2015	6-Gingerol possesses a repressive property on hepatic steatosis, which is associated with induction of peroxisome proliferator-activated receptor alpha.	gingerol	0-10	peroxisome proliferator activated receptor alpha	Mus musculus	103-151
25148824-0	2015	[10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells.	gingerol	5-13	mitogen-activated protein kinase 1	Homo sapiens	68-72
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	BCL2 apoptosis regulator	Homo sapiens	121-126
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	caspase 9	Homo sapiens	159-168
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	caspase 3	Homo sapiens	170-179
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	poly(ADP-ribose) polymerase 1	Homo sapiens	185-211
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 8	Homo sapiens	133-156
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 8	Homo sapiens	158-161
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 14	Homo sapiens	164-167
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 14	Homo sapiens	174-177
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 1	Homo sapiens	184-221
25148824-5	2015	Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).	gingerol	15-23	mitogen-activated protein kinase 1	Homo sapiens	223-226
25221872-7	2014	Combined EGCG + GING induced apoptosis in both 1321N1 and LN18 cells, as evidenced by Annexin-V FITC/PI staining and increased active caspase-3.	gingerol	16-20	annexin A5	Homo sapiens	86-95
24615565-7	2014	Rats treated with gingerol and fed a HFD showed significantly (P < 0.05) decreased glucose level, body weight, leptin, insulin, amylase, lipase plasma and tissue lipids when compared to normal control.	gingerol	18-26	leptin	Rattus norvegicus	114-120
24615565-7	2014	Rats treated with gingerol and fed a HFD showed significantly (P < 0.05) decreased glucose level, body weight, leptin, insulin, amylase, lipase plasma and tissue lipids when compared to normal control.	gingerol	18-26	lipase G, endothelial type	Rattus norvegicus	140-146
25323950-5	2014	The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6-gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin-3 as well as MMP-9 activity regardless of their concentration in SCRT water extract.	gingerol	118-128	C-C motif chemokine ligand 5	Homo sapiens	187-193
25323950-5	2014	The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6-gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin-3 as well as MMP-9 activity regardless of their concentration in SCRT water extract.	gingerol	118-128	C-C motif chemokine ligand 11	Homo sapiens	195-202
25323950-5	2014	The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6-gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin-3 as well as MMP-9 activity regardless of their concentration in SCRT water extract.	gingerol	118-128	C-C motif chemokine ligand 26	Homo sapiens	207-216
25323950-5	2014	The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6-gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin-3 as well as MMP-9 activity regardless of their concentration in SCRT water extract.	gingerol	118-128	matrix metallopeptidase 9	Homo sapiens	228-233
24615565-0	2014	Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet.	gingerol	23-31	leptin	Rattus norvegicus	67-73
24615565-0	2014	Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet.	gingerol	23-31	lipase G, endothelial type	Rattus norvegicus	87-93
25221872-7	2014	Combined EGCG + GING induced apoptosis in both 1321N1 and LN18 cells, as evidenced by Annexin-V FITC/PI staining and increased active caspase-3.	gingerol	16-20	caspase 3	Homo sapiens	134-143
25157570-8	2014	We report the inhibition of ERK1/2/JNK/AP-1 pathway as a possible mechanism behind the anticancer as well as chemopreventive efficacy of [6]-gingerol against colon cancer.	gingerol	137-149	mitogen-activated protein kinase 3	Homo sapiens	28-34
25157570-8	2014	We report the inhibition of ERK1/2/JNK/AP-1 pathway as a possible mechanism behind the anticancer as well as chemopreventive efficacy of [6]-gingerol against colon cancer.	gingerol	137-149	mitogen-activated protein kinase 8	Homo sapiens	35-38
25157570-0	2014	[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling.	gingerol	4-12	mitogen-activated protein kinase 3	Homo sapiens	124-128
23519881-7	2014	Treatment of differentiated 3T3-L1 cells with 6-gingerol (50 micromol/l) antagonized RGZ-induced gene expression of peroxisome proliferator-activated receptor (PPAR)gamma and CCAAT/enhancer-binding protein alpha.	gingerol	46-56	peroxisome proliferator activated receptor gamma	Mus musculus	160-170
25157570-5	2014	Sensitivity to [6]-gingerol in SW-480 cells was associated with activation of caspases 8, 9, 3 &7 and cleavage of PARP, which attests induction of apoptotic cell death.	gingerol	15-27	collagen type XI alpha 2 chain	Homo sapiens	118-122
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	gingerol	17-29	mitogen-activated protein kinase 3	Homo sapiens	104-110
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	gingerol	17-29	mitogen-activated protein kinase 8	Homo sapiens	115-118
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	gingerol	17-29	nuclear factor kappa B subunit 1	Homo sapiens	259-269
23519881-7	2014	Treatment of differentiated 3T3-L1 cells with 6-gingerol (50 micromol/l) antagonized RGZ-induced gene expression of peroxisome proliferator-activated receptor (PPAR)gamma and CCAAT/enhancer-binding protein alpha.	gingerol	46-56	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	175-211
23519881-8	2014	Additionally, the increased levels of mRNA and protein in adipocyte-specific fatty acid binding protein 4 and fatty acid synthase induced by RGZ in 3T3-L1 cells were decreased upon treatment with 6-gingerol.	gingerol	196-206	fatty acid binding protein 4, adipocyte	Mus musculus	77-105
23770984-5	2013	RESULTS: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6.	gingerol	19-28	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	48-54
23519881-8	2014	Additionally, the increased levels of mRNA and protein in adipocyte-specific fatty acid binding protein 4 and fatty acid synthase induced by RGZ in 3T3-L1 cells were decreased upon treatment with 6-gingerol.	gingerol	196-206	fatty acid synthase	Mus musculus	110-129
23519881-9	2014	Our data suggests that 6-gingerol may be beneficial in obesity, by reducing adipogenesis partly through the down-regulating PPARgamma activity.	gingerol	23-33	peroxisome proliferator activated receptor gamma	Mus musculus	124-133
24302912-0	2013	The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK.	gingerol	44-54	potassium two pore domain channel subfamily K member 18	Homo sapiens	142-147
24302912-4	2013	We investigated whether the pungent substances piperine, capsaicin, 6-gingerol and polygodial have an effect on human K2P channels.	gingerol	68-78	keratin 76	Homo sapiens	118-121
24624885-8	2013	Along with the growth inhibition of DPCs by 6-gingerol, the Bax/Bcl-2 ratio increased obviously.	gingerol	44-54	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
24624885-8	2013	Along with the growth inhibition of DPCs by 6-gingerol, the Bax/Bcl-2 ratio increased obviously.	gingerol	44-54	BCL2 apoptosis regulator	Homo sapiens	64-69
24624885-10	2013	CONCLUSIONS: 6-Gingerol can suppress human hair shaft elongation because it has pro-apoptotic effects on DPCs via increasing Bax/Bcl-2 ratio.	gingerol	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
24624885-10	2013	CONCLUSIONS: 6-Gingerol can suppress human hair shaft elongation because it has pro-apoptotic effects on DPCs via increasing Bax/Bcl-2 ratio.	gingerol	13-23	BCL2 apoptosis regulator	Homo sapiens	129-134
25866303-0	2014	[6]-gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1.	gingerol	4-12	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
25866303-6	2014	In addition, DeltaPD induction by [6]-gingerol was greatly diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1.	gingerol	34-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-130
25866303-7	2014	These results suggest that [6]-gingerol induced the electrogenic absorption of sodium in the rat colon via TRPV1.	gingerol	27-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-112
23770984-5	2013	RESULTS: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6.	gingerol	19-28	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	96-103
23770984-5	2013	RESULTS: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6.	gingerol	19-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
23770984-5	2013	RESULTS: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6.	gingerol	19-28	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	137-143
23770984-7	2013	By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence.	gingerol	142-151	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161
23770984-8	2013	In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4.	gingerol	58-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102
23499698-0	2013	Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca2+-ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia.	gingerol	17-25	ATPase, Ca++ transporting, ubiquitous	Mus musculus	45-84
23738730-0	2013	(S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.	gingerol	0-16	transforming growth factor beta 1	Homo sapiens	26-34
23738730-0	2013	(S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.	gingerol	0-16	biglycan	Homo sapiens	46-54
23738730-3	2013	We evaluated the effects of (S)-[6]-gingerol on these TGF-beta-mediated proteoglycan changes to explore its potential as an anti-atherosclerotic agent.	gingerol	28-44	transforming growth factor beta 1	Homo sapiens	54-62
23738730-5	2013	Biglycan level was assessed by real-time quantitative polymerase chain reactions and the effects of (S)-[6]-gingerol on TGF-beta signalling by assessment of the phosphorylation of Smads and Akt by western blotting.	gingerol	100-116	transforming growth factor beta 1	Homo sapiens	120-128
23738730-6	2013	KEY FINDINGS: (S)-[6]-Gingerol concentration-dependently inhibited TGF-beta-stimulated proteoglycan core protein synthesis, and this was not secondary to inhibition of total protein synthesis.	gingerol	14-30	transforming growth factor beta 1	Homo sapiens	67-75
23738730-7	2013	(S)-[6]-Gingerol inhibited biglycan mRNA expression.	gingerol	0-16	biglycan	Homo sapiens	27-35
23738730-9	2013	CONCLUSIONS: The activity of (S)-[6]-gingerol to inhibit TGF-beta-stimulated biglycan synthesis suggests a potential role for ginger in the prevention of atherosclerosis or other lipid-binding diseases.	gingerol	29-45	transforming growth factor beta 1	Homo sapiens	57-65
23738730-9	2013	CONCLUSIONS: The activity of (S)-[6]-gingerol to inhibit TGF-beta-stimulated biglycan synthesis suggests a potential role for ginger in the prevention of atherosclerosis or other lipid-binding diseases.	gingerol	29-45	biglycan	Homo sapiens	77-85
23738730-10	2013	The signalling studies indicate a novel site of action of (S)-[6]-gingerol in inhibiting TGF-beta responses.	gingerol	58-74	transforming growth factor beta 1	Homo sapiens	89-97
23065130-7	2013	Four purified constituents of ginger were subsequently tested for ASM relaxant properties in both guinea pig and human tracheas: [6]-gingerol, [8]-gingerol, and [6]-shogaol induced rapid relaxation of precontracted ASM (100-300 muM), whereas [10]-gingerol failed to induce relaxation.	gingerol	129-141	latexin	Homo sapiens	228-231
23369342-12	2013	6-Gingerol also inhibited differentiation in 3T3-L1 cells by attenuating the Akt/GSK3beta pathway.	gingerol	0-10	glycogen synthase kinase 3 beta	Mus musculus	81-89
23369342-8	2013	Treatment of 3T3-L1 cells with 6-gingerol reduced the protein levels of peroxisome proliferator-activated receptor (PPAR)gamma and CCAAT/enhancer-binding protein (C/EBP)alpha.	gingerol	31-41	peroxisome proliferator activated receptor gamma	Mus musculus	116-126
23369342-8	2013	Treatment of 3T3-L1 cells with 6-gingerol reduced the protein levels of peroxisome proliferator-activated receptor (PPAR)gamma and CCAAT/enhancer-binding protein (C/EBP)alpha.	gingerol	31-41	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	163-174
23369342-9	2013	Additionally, the protein levels of fatty acid synthase (FAS) and adipocyte-specific fatty acid binding protein (aP2) decreased upon treatment with 6-gingerol.	gingerol	148-158	fatty acid synthase	Mus musculus	36-55
23369342-9	2013	Additionally, the protein levels of fatty acid synthase (FAS) and adipocyte-specific fatty acid binding protein (aP2) decreased upon treatment with 6-gingerol.	gingerol	148-158	fatty acid synthase	Mus musculus	57-60
23369342-9	2013	Additionally, the protein levels of fatty acid synthase (FAS) and adipocyte-specific fatty acid binding protein (aP2) decreased upon treatment with 6-gingerol.	gingerol	148-158	fatty acid binding protein 4, adipocyte	Mus musculus	113-116
23369342-10	2013	Meanwhile, 6-gingerol diminished the insulin-stimulated serine phosphorylation of Akt (Ser473) and GSK3beta (Ser9).	gingerol	11-21	thymoma viral proto-oncogene 1	Mus musculus	82-85
23369342-10	2013	Meanwhile, 6-gingerol diminished the insulin-stimulated serine phosphorylation of Akt (Ser473) and GSK3beta (Ser9).	gingerol	11-21	glycogen synthase kinase 3 beta	Mus musculus	99-107
23369342-11	2013	These results suggest that 6-gingerol effectively suppresses adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARgamma and C/EBPalpha and subsequently inhibits FAS and aP2 expression.	gingerol	27-37	peroxisome proliferator activated receptor gamma	Mus musculus	152-161
23369342-11	2013	These results suggest that 6-gingerol effectively suppresses adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARgamma and C/EBPalpha and subsequently inhibits FAS and aP2 expression.	gingerol	27-37	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	166-176
23369342-11	2013	These results suggest that 6-gingerol effectively suppresses adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARgamma and C/EBPalpha and subsequently inhibits FAS and aP2 expression.	gingerol	27-37	fatty acid synthase	Mus musculus	203-206
23369342-11	2013	These results suggest that 6-gingerol effectively suppresses adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARgamma and C/EBPalpha and subsequently inhibits FAS and aP2 expression.	gingerol	27-37	fatty acid binding protein 4, adipocyte	Mus musculus	211-214
23369342-12	2013	6-Gingerol also inhibited differentiation in 3T3-L1 cells by attenuating the Akt/GSK3beta pathway.	gingerol	0-10	thymoma viral proto-oncogene 1	Mus musculus	77-80
23065130-7	2013	Four purified constituents of ginger were subsequently tested for ASM relaxant properties in both guinea pig and human tracheas: [6]-gingerol, [8]-gingerol, and [6]-shogaol induced rapid relaxation of precontracted ASM (100-300 muM), whereas [10]-gingerol failed to induce relaxation.	gingerol	132-141	latexin	Homo sapiens	228-231
23065130-8	2013	In human ASM cells, exposure to [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol (100 muM), blunted subsequent Ca(2+) responses to bradykinin (10 muM) and S-(-)-Bay K 8644 (10 muM).	gingerol	32-44	kininogen 1	Homo sapiens	149-159
23065130-8	2013	In human ASM cells, exposure to [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol (100 muM), blunted subsequent Ca(2+) responses to bradykinin (10 muM) and S-(-)-Bay K 8644 (10 muM).	gingerol	32-44	latexin	Homo sapiens	164-167
23065130-8	2013	In human ASM cells, exposure to [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol (100 muM), blunted subsequent Ca(2+) responses to bradykinin (10 muM) and S-(-)-Bay K 8644 (10 muM).	gingerol	32-44	latexin	Homo sapiens	164-167
23861719-9	2013	In conclusion, combination of higenamine and [6]-gingerol exerts cardioprotective effect against doxorubicin-induced cardiotoxicity through activating the PI3K/Akt signaling pathway.	gingerol	45-57	AKT serine/threonine kinase 1	Rattus norvegicus	160-163
23956783-4	2013	Previously, we reported that S-[6]-gingerol is an efficacious agonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1) in neurones.	gingerol	29-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-141
23843863-0	2013	Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells.	gingerol	44-58	nuclear factor kappa B subunit 1	Homo sapiens	81-91
23843863-0	2013	Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells.	gingerol	44-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-96
23843863-0	2013	Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells.	gingerol	44-58	MIR7-3 host gene	Homo sapiens	111-115
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	interleukin 1 beta	Homo sapiens	26-33
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	MIR7-3 host gene	Homo sapiens	79-83
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	interleukin 6	Homo sapiens	153-156
23843863-13	2013	Of particular note, the protective effect of S-[6]-gingerol against the IL1beta-induced inflammatory response was similar to that of BHT, an ROS scavenger.	gingerol	45-59	interleukin 1 beta	Homo sapiens	72-79
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	gingerol	44-58	MIR7-3 host gene	Homo sapiens	68-72
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	gingerol	44-58	interleukin 1 beta	Homo sapiens	87-94
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	gingerol	44-58	nuclear factor kappa B subunit 1	Homo sapiens	154-164
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	gingerol	44-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	165-169
23956783-9	2013	We found that S-[6]-gingerol induced rapid NF kappa B activation through TRPV1 in HuH-7 cells.	gingerol	14-28	nuclear factor kappa B subunit 1	Homo sapiens	43-53
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
23956783-4	2013	Previously, we reported that S-[6]-gingerol is an efficacious agonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1) in neurones.	gingerol	29-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
23956783-9	2013	We found that S-[6]-gingerol induced rapid NF kappa B activation through TRPV1 in HuH-7 cells.	gingerol	14-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	serum amyloid A1	Homo sapiens	167-171
23956783-10	2013	Furthermore, S-[6]-gingerol-induced NF kappa B activation was dependent on the calcium gradient and TRPV1.	gingerol	13-27	nuclear factor kappa B subunit 1	Homo sapiens	36-46
23956783-7	2013	The increase in [Ca(2+)] i induced by S-[6]-gingerol was abolished by preincubation with EGTA and was also inhibited by the TRPV1 channel antagonist capsazepine.	gingerol	38-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	124-129
23956783-10	2013	Furthermore, S-[6]-gingerol-induced NF kappa B activation was dependent on the calcium gradient and TRPV1.	gingerol	13-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
23014738-9	2012	Notably, pretreatment with 6-gingerol significantly ameliorated the changes in sRAGE, NF-kappaB and cardiac caspase-3.	gingerol	27-37	caspase 3	Rattus norvegicus	108-117
23956783-11	2013	The rapid NF kappa B activation by S-[6]-gingerol was associated with an increase in mRNA levels of NF kappa B-target genes: cIAP-2, XIAP, and Bcl-2 that encode antiapoptotic proteins.	gingerol	35-49	nuclear factor kappa B subunit 1	Homo sapiens	10-20
23956783-11	2013	The rapid NF kappa B activation by S-[6]-gingerol was associated with an increase in mRNA levels of NF kappa B-target genes: cIAP-2, XIAP, and Bcl-2 that encode antiapoptotic proteins.	gingerol	35-49	nuclear factor kappa B subunit 1	Homo sapiens	100-110
23956783-11	2013	The rapid NF kappa B activation by S-[6]-gingerol was associated with an increase in mRNA levels of NF kappa B-target genes: cIAP-2, XIAP, and Bcl-2 that encode antiapoptotic proteins.	gingerol	35-49	baculoviral IAP repeat containing 3	Homo sapiens	125-131
23956783-11	2013	The rapid NF kappa B activation by S-[6]-gingerol was associated with an increase in mRNA levels of NF kappa B-target genes: cIAP-2, XIAP, and Bcl-2 that encode antiapoptotic proteins.	gingerol	35-49	X-linked inhibitor of apoptosis	Homo sapiens	133-137
23956783-11	2013	The rapid NF kappa B activation by S-[6]-gingerol was associated with an increase in mRNA levels of NF kappa B-target genes: cIAP-2, XIAP, and Bcl-2 that encode antiapoptotic proteins.	gingerol	35-49	BCL2 apoptosis regulator	Homo sapiens	143-148
23437345-6	2013	The growth inhibition of DPCs by 6-gingerol in vitro may reflect a decrease in the Bcl-2/Bax ratio.	gingerol	33-43	BCL2 apoptosis regulator	Homo sapiens	83-88
23437345-6	2013	The growth inhibition of DPCs by 6-gingerol in vitro may reflect a decrease in the Bcl-2/Bax ratio.	gingerol	33-43	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	24-dehydrocholesterol reductase	Homo sapiens	234-240
23843863-10	2013	In addition, S-[6]-gingerol reduced IL1beta-induced COX2 upregulation as well as NF kappa B activity.	gingerol	13-27	interleukin 1 beta	Homo sapiens	36-43
23843863-10	2013	In addition, S-[6]-gingerol reduced IL1beta-induced COX2 upregulation as well as NF kappa B activity.	gingerol	13-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-56
23843863-10	2013	In addition, S-[6]-gingerol reduced IL1beta-induced COX2 upregulation as well as NF kappa B activity.	gingerol	13-27	nuclear factor kappa B subunit 1	Homo sapiens	81-91
24204396-0	2013	[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- kappa B/Snail Signal Transduction Pathway.	gingerol	0-12	matrix metallopeptidase 9	Homo sapiens	70-74
24204396-0	2013	[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- kappa B/Snail Signal Transduction Pathway.	gingerol	0-12	mitogen-activated protein kinase 1	Homo sapiens	123-126
24204396-0	2013	[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- kappa B/Snail Signal Transduction Pathway.	gingerol	0-12	nuclear factor kappa B subunit 1	Homo sapiens	127-138
24204396-0	2013	[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- kappa B/Snail Signal Transduction Pathway.	gingerol	0-12	snail family transcriptional repressor 1	Homo sapiens	139-144
24204396-4	2013	TJ protein levels, including zonula occludens (ZO-) 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity.	gingerol	98-106	tight junction protein 1	Homo sapiens	29-53
24204396-4	2013	TJ protein levels, including zonula occludens (ZO-) 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity.	gingerol	98-106	occludin	Homo sapiens	55-63
24204396-4	2013	TJ protein levels, including zonula occludens (ZO-) 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity.	gingerol	98-106	cadherin 1	Homo sapiens	69-79
24204396-4	2013	TJ protein levels, including zonula occludens (ZO-) 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity.	gingerol	98-106	matrix metallopeptidase 9	Homo sapiens	180-183
24204396-5	2013	Furthermore, NF- kappa B/Snail nuclear translocation was suppressed via downregulation of the extracellular signal-regulated kinase (ERK) pathway in response to [6]-gingerol treatment.	gingerol	165-173	nuclear factor kappa B subunit 1	Homo sapiens	13-24
24204396-5	2013	Furthermore, NF- kappa B/Snail nuclear translocation was suppressed via downregulation of the extracellular signal-regulated kinase (ERK) pathway in response to [6]-gingerol treatment.	gingerol	165-173	snail family transcriptional repressor 1	Homo sapiens	25-30
24204396-5	2013	Furthermore, NF- kappa B/Snail nuclear translocation was suppressed via downregulation of the extracellular signal-regulated kinase (ERK) pathway in response to [6]-gingerol treatment.	gingerol	165-173	mitogen-activated protein kinase 1	Homo sapiens	94-131
24204396-5	2013	Furthermore, NF- kappa B/Snail nuclear translocation was suppressed via downregulation of the extracellular signal-regulated kinase (ERK) pathway in response to [6]-gingerol treatment.	gingerol	165-173	mitogen-activated protein kinase 1	Homo sapiens	133-136
24204396-7	2013	In conclusion, these findings demonstrate that [6]-gingerol regulates TJ-related proteins and suppresses invasion and metastasis through NF- kappa B/Snail inhibition via inhibition of the ERK pathway.	gingerol	47-59	nuclear factor kappa B subunit 1	Homo sapiens	137-148
24204396-7	2013	In conclusion, these findings demonstrate that [6]-gingerol regulates TJ-related proteins and suppresses invasion and metastasis through NF- kappa B/Snail inhibition via inhibition of the ERK pathway.	gingerol	47-59	snail family transcriptional repressor 1	Homo sapiens	149-154
24204396-7	2013	In conclusion, these findings demonstrate that [6]-gingerol regulates TJ-related proteins and suppresses invasion and metastasis through NF- kappa B/Snail inhibition via inhibition of the ERK pathway.	gingerol	47-59	mitogen-activated protein kinase 1	Homo sapiens	188-191
22761764-7	2012	We confirmed that ginger and 10-gingerol promote the expression of gata1 in erythroid cells and increase the expression of hematopoietic progenitor markers cmyb and scl.	gingerol	29-40	GATA binding protein 1a	Danio rerio	67-72
21792901-5	2012	6-Gingerol treatment of tumor-bearing mice caused massive infiltration of CD4 and CD8 T-cells and B220(+)  B-cells, but reduced the number of CD4(+) Foxp3(+)  regulatory T-cells.	gingerol	0-10	CD4 antigen	Mus musculus	74-77
21792901-5	2012	6-Gingerol treatment of tumor-bearing mice caused massive infiltration of CD4 and CD8 T-cells and B220(+)  B-cells, but reduced the number of CD4(+) Foxp3(+)  regulatory T-cells.	gingerol	0-10	CD4 antigen	Mus musculus	142-145
21792901-5	2012	6-Gingerol treatment of tumor-bearing mice caused massive infiltration of CD4 and CD8 T-cells and B220(+)  B-cells, but reduced the number of CD4(+) Foxp3(+)  regulatory T-cells.	gingerol	0-10	forkhead box P3	Mus musculus	149-154
21792901-6	2012	The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-gamma, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on T(H) 1 cells, such as CXCR3 and CCR5.	gingerol	44-54	interferon gamma	Mus musculus	87-96
21792901-6	2012	The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-gamma, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on T(H) 1 cells, such as CXCR3 and CCR5.	gingerol	44-54	lysosomal-associated membrane protein 1	Mus musculus	154-160
21792901-6	2012	The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-gamma, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on T(H) 1 cells, such as CXCR3 and CCR5.	gingerol	44-54	chemokine (C-X-C motif) receptor 3	Mus musculus	229-234
21792901-6	2012	The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-gamma, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on T(H) 1 cells, such as CXCR3 and CCR5.	gingerol	44-54	chemokine (C-C motif) receptor 5	Mus musculus	239-243
21698672-4	2012	An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	gingerol	267-275	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	116-119
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	120-124
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin dependent kinase 1	Homo sapiens	167-171
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin A2	Homo sapiens	173-181
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin B1	Homo sapiens	187-196
23034900-0	2012	[6]-Gingerol induces bone loss in ovary intact adult mice and augments osteoclast function via the transient receptor potential vanilloid 1 channel.	gingerol	4-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	99-139
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	gingerol	133-143	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	gingerol	133-143	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-76
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	gingerol	133-143	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	172-177
23034900-12	2012	CONCLUSION: Daily feeding of 6-gingerol to skeletally mature female mice caused trabecular osteopenia, and the mechanism appeared to be activation of osteoclast formation via the TRPV1 channel.	gingerol	29-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	179-184
22939973-0	2012	[6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells.	gingerol	0-12	caspase 3	Homo sapiens	21-30
22939973-5	2012	The expression of caspase 3 and PARP was increased in cells exposed to [6]-gingerol.	gingerol	71-83	caspase 3	Homo sapiens	18-27
22939973-5	2012	The expression of caspase 3 and PARP was increased in cells exposed to [6]-gingerol.	gingerol	71-83	collagen type XI alpha 2 chain	Homo sapiens	32-36
22939973-7	2012	The over-expression of NFkbeta, AKT and Bcl2 genes in cancer cells was down-regulated by [6]-gingerol treatment.	gingerol	93-101	AKT serine/threonine kinase 1	Homo sapiens	32-35
22939973-7	2012	The over-expression of NFkbeta, AKT and Bcl2 genes in cancer cells was down-regulated by [6]-gingerol treatment.	gingerol	93-101	BCL2 apoptosis regulator	Homo sapiens	40-44
22939973-8	2012	On the other hand the expression levels of TNFalpha, Bax and cytochrome c were enhanced in [6]-gingerol treated cells.	gingerol	95-103	tumor necrosis factor	Homo sapiens	43-51
22939973-8	2012	On the other hand the expression levels of TNFalpha, Bax and cytochrome c were enhanced in [6]-gingerol treated cells.	gingerol	95-103	BCL2 associated X, apoptosis regulator	Homo sapiens	53-56
22939973-8	2012	On the other hand the expression levels of TNFalpha, Bax and cytochrome c were enhanced in [6]-gingerol treated cells.	gingerol	95-103	cytochrome c, somatic	Homo sapiens	61-73
22939973-9	2012	Thus, overall results suggest that [6]-gingerol has potential to bind with DNA and induce cell death by autophagy and caspase 3 mediated apoptosis.	gingerol	39-47	caspase 3	Homo sapiens	118-127
22389213-10	2012	Taken together, these results suggest that cathepsin D may be a positive mediator of 6-gingerol induced apoptosis in HepG2 cells, acting upstream of cytochrome c release, and the apoptosis may be associated with oxidative stress.	gingerol	85-95	cathepsin D	Homo sapiens	43-54
22389213-10	2012	Taken together, these results suggest that cathepsin D may be a positive mediator of 6-gingerol induced apoptosis in HepG2 cells, acting upstream of cytochrome c release, and the apoptosis may be associated with oxidative stress.	gingerol	85-95	cytochrome c, somatic	Homo sapiens	149-161
22858304-4	2012	[6]-, [8]- and [10]-Gingerol purified by this methodology inhibited the proliferation of MDA-MB-231 tumor cell line with IC50 of 666.2+-134.6 muM, 135.6+-22.6 muM and 12.1+-0.3 muM, respectively.	gingerol	20-28	latexin	Homo sapiens	142-145
22858304-4	2012	[6]-, [8]- and [10]-Gingerol purified by this methodology inhibited the proliferation of MDA-MB-231 tumor cell line with IC50 of 666.2+-134.6 muM, 135.6+-22.6 muM and 12.1+-0.3 muM, respectively.	gingerol	20-28	latexin	Homo sapiens	159-162
22858304-4	2012	[6]-, [8]- and [10]-Gingerol purified by this methodology inhibited the proliferation of MDA-MB-231 tumor cell line with IC50 of 666.2+-134.6 muM, 135.6+-22.6 muM and 12.1+-0.3 muM, respectively.	gingerol	20-28	latexin	Homo sapiens	159-162
22714996-2	2012	The aims of this study were to evaluate the inhibitory effect and molecular mechanism underlying the transcription and translation of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA) in Hep3B cells as well as the antiangiogenic activity of 6-gingerol and 6-shogaol.	gingerol	271-281	matrix metallopeptidase 2	Homo sapiens	161-165
22714996-3	2012	METHODS AND RESULTS: By gelatin zymography and luciferase reporter gene assays, we found that 6-gingerol and 6-shogaol regulate MMP-2/-9 transcription.	gingerol	94-104	matrix metallopeptidase 2	Homo sapiens	128-136
22714996-4	2012	Moreover, 6-gingerol directly decreased expression of uPA, but the 6-shogaol-mediated decrease in uPA was accompanied by up-regulation of plasminogen activator inhibitor (PAI)-1.	gingerol	10-20	plasminogen activator, urokinase	Homo sapiens	54-57
22714996-5	2012	6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3.	gingerol	0-10	AKT serine/threonine kinase 1	Homo sapiens	185-188
22714996-5	2012	6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3.	gingerol	0-10	nuclear factor kappa B subunit 1	Homo sapiens	218-227
22714996-5	2012	6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3.	gingerol	0-10	nuclear factor kappa B subunit 1	Homo sapiens	254-263
22714996-5	2012	6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3.	gingerol	0-10	signal transducer and activator of transcription 3	Homo sapiens	268-273
22714996-7	2012	CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis.	gingerol	26-36	AKT serine/threonine kinase 1	Homo sapiens	189-192
22714996-7	2012	CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis.	gingerol	26-36	nuclear factor kappa B subunit 1	Homo sapiens	206-215
22714996-7	2012	CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis.	gingerol	26-36	signal transducer and activator of transcription 3	Homo sapiens	220-225
22714996-7	2012	CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis.	gingerol	26-36	matrix metallopeptidase 2	Homo sapiens	263-271
22714996-7	2012	CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis.	gingerol	26-36	plasminogen activator, urokinase	Homo sapiens	276-279
22285432-3	2012	[6]-Gingerol treatment reduced elevated blood glucose level and oxidative stress by enhancing activity of super oxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and GSH.	gingerol	4-12	catalase	Mus musculus	135-143
22285432-7	2012	The over-expression of TNFalpha and IL6 in iAs intoxicated mice was down-regulated by [6]-gingerol treatment.	gingerol	90-98	tumor necrosis factor	Mus musculus	23-31
22285432-7	2012	The over-expression of TNFalpha and IL6 in iAs intoxicated mice was down-regulated by [6]-gingerol treatment.	gingerol	90-98	interleukin 6	Mus musculus	36-39
22257892-0	2012	Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.	gingerol	43-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
22257892-0	2012	Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.	gingerol	43-51	transient receptor potential cation channel subfamily A member 1	Homo sapiens	112-117
22257892-2	2012	The exploration of the structure-activity relationships, by modulating the three pharmacophoric regions of [6]-gingerol, led to the identification of some selective TRPV1 agonists/desensitizers of TRPV1 channels (3a, 3f, and 4) and of some full TRPA1 antagonists (2c, 2d, 3b, and 3d).	gingerol	107-119	transient receptor potential cation channel subfamily V member 1	Homo sapiens	165-170
22257892-2	2012	The exploration of the structure-activity relationships, by modulating the three pharmacophoric regions of [6]-gingerol, led to the identification of some selective TRPV1 agonists/desensitizers of TRPV1 channels (3a, 3f, and 4) and of some full TRPA1 antagonists (2c, 2d, 3b, and 3d).	gingerol	107-119	transient receptor potential cation channel subfamily V member 1	Homo sapiens	197-202
22257892-2	2012	The exploration of the structure-activity relationships, by modulating the three pharmacophoric regions of [6]-gingerol, led to the identification of some selective TRPV1 agonists/desensitizers of TRPV1 channels (3a, 3f, and 4) and of some full TRPA1 antagonists (2c, 2d, 3b, and 3d).	gingerol	107-119	transient receptor potential cation channel subfamily A member 1	Homo sapiens	245-250
22297756-7	2012	However, the decreases in mRNA levels of antioxidant enzymes and SOD activity were significantly restored to the control levels by [6]-gingerol supplement.	gingerol	131-143	superoxide dismutase 1, soluble	Mus musculus	65-68
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin A2	Homo sapiens	37-45
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin dependent kinase 1	Homo sapiens	62-66
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	interferon alpha inducible protein 27	Homo sapiens	142-145
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin dependent kinase inhibitor 1B	Homo sapiens	146-150
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin dependent kinase inhibitor 1A	Homo sapiens	156-159
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin dependent kinase inhibitor 1A	Homo sapiens	160-164
22719783-8	2012	In addition, 6-gingerol treatment elevated intracellular reactive oxygen species (ROS) and phosphorylation level of p53.	gingerol	13-23	tumor protein p53	Homo sapiens	116-119
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	tumor protein p53	Homo sapiens	96-99
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	interferon alpha inducible protein 27	Homo sapiens	101-104
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin dependent kinase inhibitor 1B	Homo sapiens	105-109
22088594-4	2011	RESULTS: The treatment of 6-gingerol and silymarin to acetaminophen-induced hepatotoxicity showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, and ALP) and total bilirubin in serum (P<0.05).	gingerol	26-36	glutamic pyruvic transaminase, soluble	Mus musculus	179-182
21846463-0	2011	10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.	gingerol	0-11	ghrelin and obestatin prepropeptide	Rattus norvegicus	100-107
22088594-4	2011	RESULTS: The treatment of 6-gingerol and silymarin to acetaminophen-induced hepatotoxicity showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, and ALP) and total bilirubin in serum (P<0.05).	gingerol	26-36	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	174-177
21846463-5	2011	In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation.	gingerol	13-24	ghrelin and obestatin prepropeptide	Rattus norvegicus	66-73
21382473-0	2011	Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1alpha and intracellular superoxide dismutases.	gingerol	11-23	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-147
21396424-3	2011	[6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3.	gingerol	4-12	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190
21396424-3	2011	[6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3.	gingerol	4-12	BCL2 apoptosis regulator	Homo sapiens	191-196
21396424-3	2011	[6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3.	gingerol	4-12	caspase 3	Homo sapiens	222-231
21396424-6	2011	Furthermore, [6]-gingerol treatment up-regulated the mRNA and protein expression of antioxidant enzymes such as gamma-glutamylcysteine ligase (GCL) and heme oxygenase-1 (HO-1), the rate limiting enzymes in the glutathione biosynthesis and the degradation of heme, respectively.	gingerol	17-25	glutamate-cysteine ligase catalytic subunit	Homo sapiens	112-141
21396424-6	2011	Furthermore, [6]-gingerol treatment up-regulated the mRNA and protein expression of antioxidant enzymes such as gamma-glutamylcysteine ligase (GCL) and heme oxygenase-1 (HO-1), the rate limiting enzymes in the glutathione biosynthesis and the degradation of heme, respectively.	gingerol	17-25	glutamate-cysteine ligase catalytic subunit	Homo sapiens	143-146
21396424-6	2011	Furthermore, [6]-gingerol treatment up-regulated the mRNA and protein expression of antioxidant enzymes such as gamma-glutamylcysteine ligase (GCL) and heme oxygenase-1 (HO-1), the rate limiting enzymes in the glutathione biosynthesis and the degradation of heme, respectively.	gingerol	17-25	heme oxygenase 1	Homo sapiens	152-168
21382473-4	2011	Our findings indicate that antioxidants such as emodin, [6]-gingerol, and MnTBAP lessen hypoxia-induced embryotoxicities via upregulation of HIF-1alpha and intracellular SODs.	gingerol	56-68	hypoxia inducible factor 1, alpha subunit	Mus musculus	141-151
19531649-4	2009	Our in silico prediction using a reverse-docking approach revealed that LTA(4)H might be a potential target of [6]-gingerol.	gingerol	111-123	leukotriene A4 hydrolase	Homo sapiens	72-79
21670536-5	2011	The results revealed that [6]-gingerol (25-100 microM) effectively suppresses murine tyrosinase activity and decreases the amount of melanin in a dose-dependent manner.	gingerol	26-38	tyrosinase	Mus musculus	85-95
20521273-6	2010	Upon incubation of PMA-treated HepG2 cells and PMA-untreated Hep3B cells with 6-shogaol and 6-gingerol, matrix metalloproteinase (MMP)-9 activity decreased, whereas the expression of tissue inhibitor metalloproteinase protein (TIMP)-1 increased in both cell types.	gingerol	92-102	matrix metallopeptidase 9	Homo sapiens	104-136
19671252-0	2009	[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.	gingerol	4-12	interleukin 1 beta	Homo sapiens	24-42
19671252-0	2009	[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.	gingerol	4-12	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
19671252-2	2009	The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathway.	gingerol	39-51	interleukin 1 beta	Homo sapiens	63-86
19671252-2	2009	The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathway.	gingerol	39-51	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	95-101
19671252-6	2009	When the cells were pretreated with 10 microM of [6]-gingerol, expression of IL-1 beta-induced MUC5AC mRNA and protein was significantly suppressed.	gingerol	49-61	interleukin 1 beta	Homo sapiens	77-86
19671252-6	2009	When the cells were pretreated with 10 microM of [6]-gingerol, expression of IL-1 beta-induced MUC5AC mRNA and protein was significantly suppressed.	gingerol	49-61	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	95-101
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	interleukin 1 beta	Homo sapiens	15-24
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	33-39
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	mitogen-activated protein kinase 1	Homo sapiens	88-91
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	interleukin 1 beta	Homo sapiens	179-188
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	197-203
19671252-7	2009	Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways.	gingerol	146-154	mitogen-activated protein kinase 1	Homo sapiens	226-229
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	17-25	interleukin 1 beta	Homo sapiens	37-46
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	17-25	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	56-62
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	17-25	mitogen-activated protein kinase 1	Homo sapiens	120-123
19671252-8	2009	CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.	gingerol	173-181	interleukin 1 beta	Homo sapiens	37-46
20521273-6	2010	Upon incubation of PMA-treated HepG2 cells and PMA-untreated Hep3B cells with 6-shogaol and 6-gingerol, matrix metalloproteinase (MMP)-9 activity decreased, whereas the expression of tissue inhibitor metalloproteinase protein (TIMP)-1 increased in both cell types.	gingerol	92-102	TIMP metallopeptidase inhibitor 1	Homo sapiens	183-234
20521273-7	2010	Additionally, urokinase-type plasminogen activator activity was dose-dependently decreased in Hep3B cells after incubation with 6-shogaol for 24 h. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-shogaol and 6-gingerol and the regulation of TIMP-1 by 6-shogaol in Hep3B cells may on the transcriptional level.	gingerol	259-269	plasminogen activator, urokinase	Homo sapiens	14-50
20521273-7	2010	Additionally, urokinase-type plasminogen activator activity was dose-dependently decreased in Hep3B cells after incubation with 6-shogaol for 24 h. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-shogaol and 6-gingerol and the regulation of TIMP-1 by 6-shogaol in Hep3B cells may on the transcriptional level.	gingerol	259-269	matrix metallopeptidase 9	Homo sapiens	236-241
20521273-8	2010	CONCLUSIONS: These results suggest that 6-shogaol and 6-gingerol might both exert anti-invasive activity against hepatoma cells through regulation of MMP-9 and TIMP-1 and that 6-shogaol could further regulate urokinase-type plasminogen activity.	gingerol	54-64	matrix metallopeptidase 9	Homo sapiens	150-155
20521273-8	2010	CONCLUSIONS: These results suggest that 6-shogaol and 6-gingerol might both exert anti-invasive activity against hepatoma cells through regulation of MMP-9 and TIMP-1 and that 6-shogaol could further regulate urokinase-type plasminogen activity.	gingerol	54-64	TIMP metallopeptidase inhibitor 1	Homo sapiens	160-166
20338103-8	2010	RESULTS: Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM.	gingerol	110-122	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
19629484-0	2010	Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis.	gingerol	26-38	transformation related protein 53, pseudogene	Mus musculus	73-76
19629484-8	2010	Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin.	gingerol	75-87	transformation related protein 53, pseudogene	Mus musculus	130-133
19629484-8	2010	Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin.	gingerol	75-87	BCL2-associated X protein	Mus musculus	184-187
19629484-8	2010	Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin.	gingerol	75-87	B cell leukemia/lymphoma 2	Mus musculus	223-228
19629484-8	2010	Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin.	gingerol	75-87	baculoviral IAP repeat-containing 5	Mus musculus	233-241
19629484-9	2010	Further, [6]-gingerol treatment resulted in release of Cytochrome c, Caspases activation, increase in apoptotic protease-activating factor-1 (Apaf-1) as mechanism of apoptosis induction.	gingerol	13-21	apoptotic peptidase activating factor 1	Mus musculus	102-140
19629484-9	2010	Further, [6]-gingerol treatment resulted in release of Cytochrome c, Caspases activation, increase in apoptotic protease-activating factor-1 (Apaf-1) as mechanism of apoptosis induction.	gingerol	13-21	apoptotic peptidase activating factor 1	Mus musculus	142-148
19531649-5	2009	We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA(4)H activity in HCT116 colorectal cancer cells.	gingerol	44-56	leukotriene A4 hydrolase	Homo sapiens	123-130
19531649-6	2009	We showed that [6]-gingerol effectively suppressed tumor growth in vivo in nude mice, an effect that was mediated by inhibition of LTA(4)H activity.	gingerol	15-27	leukotriene A4 hydrolase	Mus musculus	131-138
19531649-7	2009	Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer.	gingerol	118-130	leukotriene A4 hydrolase	Homo sapiens	144-151
19268427-6	2009	6-Gingerol could decrease inducible nitric oxide synthase and TNF-alpha expression through suppression of I-kappaB alpha phosphorylation, NF-kappaB nuclear activation and PKC-alpha translocation, which in turn inhibits Ca(2+) mobilization and disruption of mitochondrial membrane potential in LPS-stimulated macrophages.	gingerol	0-10	tumor necrosis factor	Mus musculus	62-71
19217234-8	2009	Glucuronide of 6-gingerol, the major metabolite of 6-gingerol, was further determined after beta-glucuronidase hydrolyzation.	gingerol	15-25	glucuronidase, beta	Rattus norvegicus	92-110
19217234-8	2009	Glucuronide of 6-gingerol, the major metabolite of 6-gingerol, was further determined after beta-glucuronidase hydrolyzation.	gingerol	51-61	glucuronidase, beta	Rattus norvegicus	92-110
19268427-0	2009	6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages.	gingerol	0-10	nitric oxide synthase 2, inducible	Mus musculus	28-32
19268427-0	2009	6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages.	gingerol	0-10	protein kinase C, alpha	Mus musculus	60-69
19268427-6	2009	6-Gingerol could decrease inducible nitric oxide synthase and TNF-alpha expression through suppression of I-kappaB alpha phosphorylation, NF-kappaB nuclear activation and PKC-alpha translocation, which in turn inhibits Ca(2+) mobilization and disruption of mitochondrial membrane potential in LPS-stimulated macrophages.	gingerol	0-10	protein kinase C, alpha	Mus musculus	171-180
19268427-7	2009	Here, we demonstrate that 6-gingerol acts as an anti-inflammatory agent by blocking NF-kappaB and PKC signaling, and may be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases.	gingerol	26-36	protein kinase C, alpha	Mus musculus	98-101
18683823-2	2008	In this study, we investigated the inhibitory effects of 6-shogaol and a related compound, 6-gingerol, on the induction of nitric oxide synthase (NOS) and cyclooxygenase-2 (COX-2) in murine RAW 264.7 cells activated with LPS.	gingerol	91-101	nitric oxide synthase 1, neuronal	Mus musculus	123-144
18683823-2	2008	In this study, we investigated the inhibitory effects of 6-shogaol and a related compound, 6-gingerol, on the induction of nitric oxide synthase (NOS) and cyclooxygenase-2 (COX-2) in murine RAW 264.7 cells activated with LPS.	gingerol	91-101	prostaglandin-endoperoxide synthase 2	Mus musculus	155-171
18683823-2	2008	In this study, we investigated the inhibitory effects of 6-shogaol and a related compound, 6-gingerol, on the induction of nitric oxide synthase (NOS) and cyclooxygenase-2 (COX-2) in murine RAW 264.7 cells activated with LPS.	gingerol	91-101	prostaglandin-endoperoxide synthase 2	Mus musculus	173-178
18385293-3	2008	Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells.	gingerol	48-58	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
18385293-3	2008	Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells.	gingerol	48-58	ATP binding cassette subfamily B member 1	Homo sapiens	162-166
17683926-8	2008	The activities of MMP-2 or MMP-9 in MDA-MB-231 cells were decreased by treatment with [6]-gingerol and occurred in a dose-dependent manner.	gingerol	86-98	matrix metallopeptidase 2	Homo sapiens	18-23
17683926-8	2008	The activities of MMP-2 or MMP-9 in MDA-MB-231 cells were decreased by treatment with [6]-gingerol and occurred in a dose-dependent manner.	gingerol	86-98	matrix metallopeptidase 9	Homo sapiens	27-32
17683926-10	2008	MMP-2 and MMP-9 mRNA expression were decreased by [6]-gingerol treatment.	gingerol	54-62	matrix metallopeptidase 2	Homo sapiens	0-5
17683926-10	2008	MMP-2 and MMP-9 mRNA expression were decreased by [6]-gingerol treatment.	gingerol	54-62	matrix metallopeptidase 9	Homo sapiens	10-15
17683926-11	2008	In conclusion, we have shown that [6]-gingerol inhibits cell adhesion, invasion, motility and activities of MMP-2 and MMP-9 in MDA-MB-231 human breast cancer cell lines.	gingerol	34-46	matrix metallopeptidase 2	Homo sapiens	108-113
17683926-11	2008	In conclusion, we have shown that [6]-gingerol inhibits cell adhesion, invasion, motility and activities of MMP-2 and MMP-9 in MDA-MB-231 human breast cancer cell lines.	gingerol	34-46	matrix metallopeptidase 9	Homo sapiens	118-123
17291534-5	2007	We hypothesized that the anti-inflammatory effect of 6-gingerol is because of inhibition of macrophage activation, more specifically by an inhibition of pro-inflammatory cytokines and antigen presentation by lipopolysaccharide (LPS) activated macrophages.	gingerol	53-63	toll-like receptor 4	Mus musculus	228-231
18166202-3	2008	The ferulamides with an aromatic ring in the N-substituent are very active in inducing adiponectin as compared with the known active compounds, curcumin, [6]-gingerol, and capsaicin, and furthermore the activities of these ferulamides are remarkably stronger than those of the corresponding esters or the straight chain octylamide.	gingerol	154-166	adiponectin, C1Q and collagen domain containing	Mus musculus	87-98
18058799-7	2008	Subsequently, 6-gingerol suppressed cyclin D1 expression and induced NAG-1 expression.	gingerol	14-24	cyclin D1	Homo sapiens	36-45
18058799-7	2008	Subsequently, 6-gingerol suppressed cyclin D1 expression and induced NAG-1 expression.	gingerol	14-24	growth differentiation factor 15	Homo sapiens	69-74
18058799-9	2008	Furthermore, experiments using inhibitors and siRNA transfection confirm the involvement of the PKCepsilon and glycogen synthase kinase (GSK)-3beta pathways in 6-gingerol-induced NAG-1 expression.	gingerol	160-170	protein kinase C epsilon	Homo sapiens	96-106
18058799-9	2008	Furthermore, experiments using inhibitors and siRNA transfection confirm the involvement of the PKCepsilon and glycogen synthase kinase (GSK)-3beta pathways in 6-gingerol-induced NAG-1 expression.	gingerol	160-170	growth differentiation factor 15	Homo sapiens	179-184
18058799-10	2008	The results suggest that 6-gingerol stimulates apoptosis through upregulation of NAG-1 and G(1) cell cycle arrest through downregulation of cyclin D1.	gingerol	25-35	growth differentiation factor 15	Homo sapiens	81-86
18058799-10	2008	The results suggest that 6-gingerol stimulates apoptosis through upregulation of NAG-1 and G(1) cell cycle arrest through downregulation of cyclin D1.	gingerol	25-35	cyclin D1	Homo sapiens	140-149
18058799-11	2008	Multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as beta-catenin, PKCepsilon, and GSK-3beta pathways.	gingerol	45-55	catenin beta 1	Homo sapiens	105-117
18058799-11	2008	Multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as beta-catenin, PKCepsilon, and GSK-3beta pathways.	gingerol	45-55	protein kinase C epsilon	Homo sapiens	119-129
18058799-11	2008	Multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as beta-catenin, PKCepsilon, and GSK-3beta pathways.	gingerol	45-55	glycogen synthase kinase 3 beta	Homo sapiens	135-144
18030663-6	2007	Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate.	gingerol	45-57	transformation related protein 53, pseudogene	Mus musculus	106-109
18030663-6	2007	Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate.	gingerol	45-57	BCL2-associated X protein	Mus musculus	169-172
18030663-6	2007	Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate.	gingerol	45-57	caspase 9	Mus musculus	195-204
18030663-6	2007	Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate.	gingerol	45-57	caspase 3	Mus musculus	209-218
18030663-7	2007	We also found downregulation of testosterone induced antiapoptotic proteins, Bcl-2 and Survivin expression by [6]-gingerol in both LNCaP cells and in mouse ventral prostate.	gingerol	110-122	BCL2 apoptosis regulator	Homo sapiens	77-82
17454143-0	2007	[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo.	gingerol	4-12	cytochrome c oxidase II, mitochondrial	Mus musculus	53-58
17454143-5	2007	Translocation of NF-kappaB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of IkappaBalpha phosphorylation (ser-32).	gingerol	83-95	nuclear factor kappa B subunit 1	Homo sapiens	17-26
17454143-5	2007	Translocation of NF-kappaB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of IkappaBalpha phosphorylation (ser-32).	gingerol	83-95	NFKB inhibitor alpha	Homo sapiens	115-127
17454143-6	2007	Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 microM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappaB translocation.	gingerol	81-93	cytochrome c oxidase II, mitochondrial	Mus musculus	193-198
17454143-6	2007	Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 microM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappaB translocation.	gingerol	81-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-237
17291534-7	2007	We also studied the effect of 6-gingerol on the cell surface expression of B7.1, B7.2, and MHC II.	gingerol	30-40	CD80 antigen	Mus musculus	75-79
17291534-9	2007	RESULTS: 6-gingerol inhibited the production of pro-inflammatory cytokines from LPS stimulated macrophages but had no effect on the LPS-induced expression of B7.1, B7.2, and MHC II.	gingerol	9-19	toll-like receptor 4	Mus musculus	80-83
17066513-0	2006	[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.	gingerol	4-12	tumor protein p53	Homo sapiens	64-67
17066513-3	2006	The purpose of this study was to investigate the action of [6]-gingerol on two human pancreatic cancer cell lines, HPAC expressing wild- type (wt) p53 and BxPC-3 expressing mutated p53.	gingerol	59-71	tumor protein p53	Homo sapiens	181-184
17066513-5	2006	Western blot analyses indicated that [6]-gingerol decreased both Cyclin A and Cyclin-dependent kinase (Cdk) expression.	gingerol	37-49	cyclin A2	Homo sapiens	65-73
17066513-7	2006	p53 expression was decreased by [6]-gingerol treatment in both cell lines suggesting that the induction of Cyclin-dependent kinase inhibitor, p21cip1, was p53-independent.	gingerol	36-44	tumor protein p53	Homo sapiens	0-3
17066513-8	2006	[6]-Gingerol induced mostly apoptotic death in the mutant p53-expressing cells, while no signs of early apoptosis were detected in wild type p53-expressing cells and this was related to the increased phosphorylation of AKT.	gingerol	4-12	tumor protein p53	Homo sapiens	58-61
17066513-8	2006	[6]-Gingerol induced mostly apoptotic death in the mutant p53-expressing cells, while no signs of early apoptosis were detected in wild type p53-expressing cells and this was related to the increased phosphorylation of AKT.	gingerol	4-12	AKT serine/threonine kinase 1	Homo sapiens	219-222
17066513-9	2006	These results suggest that [6]-gingerol can circumvent the resistance of mutant p53- expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53- expressing cells by inducing temporal growth arrest.	gingerol	27-39	tumor protein p53	Homo sapiens	80-83
17066513-9	2006	These results suggest that [6]-gingerol can circumvent the resistance of mutant p53- expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53- expressing cells by inducing temporal growth arrest.	gingerol	27-39	tumor protein p53	Homo sapiens	203-206
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	gingerol	59-71	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
17176640-3	2006	All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1.	gingerol	8-17	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-132
17176640-3	2006	All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1.	gingerol	8-17	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-139
17176640-3	2006	All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1.	gingerol	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	169-174
17176640-9	2006	In conclusion, gingerols and shogaols activated TRPV1 and increased adrenaline secretion.	gingerol	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
16081047-3	2005	In vitro, [6]-gingerol inhibited both the VEGF- and bFGF-induced proliferation of human endothelial cells and caused cell cycle arrest in the G1 phase.	gingerol	10-22	vascular endothelial growth factor A	Homo sapiens	42-47
16081047-3	2005	In vitro, [6]-gingerol inhibited both the VEGF- and bFGF-induced proliferation of human endothelial cells and caused cell cycle arrest in the G1 phase.	gingerol	10-22	fibroblast growth factor 2	Homo sapiens	52-56
16732525-0	2006	Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity.	gingerol	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
16732525-0	2006	Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity.	gingerol	0-8	nitric oxide synthase 2, inducible	Mus musculus	92-96
16732525-7	2006	This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.	gingerol	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	95-108
16732525-7	2006	This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.	gingerol	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
16732525-7	2006	This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.	gingerol	54-62	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	167-170
16732525-7	2006	This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.	gingerol	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
16971750-9	2006	6-Gingerol treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation and enhanced the levels of reduced glutathione and activities of superoxide dismutase and catalase.	gingerol	0-10	catalase	Rattus norvegicus	199-207
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	gingerol	59-71	transforming growth factor beta 1	Homo sapiens	119-128
15735738-4	2005	In our present study, topical application of [6]-gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	gingerol	45-57	prostaglandin-endoperoxide synthase 2	Mus musculus	68-73
14758732-4	2003	These results suggested that the inhibition of Bcl-2 expression in HL-60 cells might account for the mechanism of 6-gingerol-induced apoptosis.	gingerol	114-124	BCL2 apoptosis regulator	Homo sapiens	47-52
15735738-0	2005	[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.	gingerol	4-12	prostaglandin-endoperoxide synthase 2	Mus musculus	22-27
15735738-0	2005	[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.	gingerol	4-12	mitogen-activated protein kinase 14	Mus musculus	69-72
15735738-0	2005	[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.	gingerol	4-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
15649425-6	2005	These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions.	gingerol	80-92	ATP binding cassette subfamily B member 1	Homo sapiens	138-152
15125461-7	2004	It is reported that resiniferatoxin, [6]-gingerol and lafutidine are compounds that activate VR1 and/or capsaicin-sensitive afferent neurons.	gingerol	37-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	93-96
15630166-0	2004	Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.	gingerol	22-34	prostaglandin-endoperoxide synthase 2	Mus musculus	50-55
15630166-0	2004	Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.	gingerol	22-34	mitogen-activated protein kinase 14	Mus musculus	99-102
15630166-4	2004	Topical application of [6]-gingerol inhibited phorbol 12-myristate 13-acetate -induced COX-2 expression.	gingerol	23-35	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
15630166-7	2004	In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression.	gingerol	13-25	mitogen-activated protein kinase 14	Mus musculus	58-61
15630166-7	2004	In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression.	gingerol	13-25	prostaglandin-endoperoxide synthase 2	Mus musculus	166-171
14572883-4	2003	Moreover, [6]-gingerol effectively suppressed peroxynitrite-induced oxidation of dichlorodihydrofluorescein, oxidative single strand breaks in supercoiled pTZ 18U plasmid DNA, and formation of 3-nitrotyrosine in bovine serum albumin (BSA) and J774.1 cells.	gingerol	10-22	albumin	Mus musculus	219-232
15735738-5	2005	Since the transcription factor nuclear factor-kappaB (NF-kappaB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-kappaB.	gingerol	143-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-52
15735738-5	2005	Since the transcription factor nuclear factor-kappaB (NF-kappaB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-kappaB.	gingerol	143-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-194
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	gingerol	18-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	gingerol	18-30	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	153-165
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	gingerol	18-30	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	182-185
15735738-7	2005	Phosphorylation of both IkappaBalpha and p65 was substantially blocked by [6]-gingerol.	gingerol	74-86	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	24-36
15735738-7	2005	Phosphorylation of both IkappaBalpha and p65 was substantially blocked by [6]-gingerol.	gingerol	74-86	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	41-44
15735738-8	2005	In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB.	gingerol	13-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	74-77
15735738-8	2005	In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB.	gingerol	13-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
15735738-9	2005	Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin.	gingerol	14-22	mitogen-activated protein kinase 14	Mus musculus	87-90
15735738-9	2005	Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin.	gingerol	14-22	prostaglandin-endoperoxide synthase 2	Mus musculus	145-150
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	gingerol	38-50	prostaglandin-endoperoxide synthase 2	Mus musculus	72-77
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	gingerol	38-50	mitogen-activated protein kinase 14	Mus musculus	127-130
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	gingerol	38-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
14758732-5	2003	In the inhibitory assay, the cytotoxic effect of 6-gingerol could be prevented by catalase.	gingerol	49-59	catalase	Homo sapiens	82-90
7791032-2	1995	Gingerol concentration-dependently (0.5-20 microM) inhibited the aggregation and release reaction of rabbit washed platelets induced by arachidonic acid and collagen, but not those induced by platelet-activating factor (PAF), U46619 (9,11-dideoxy-9 alpha,11 alpha-methano-epoxy-PGF2 alpha) and thrombin.	gingerol	0-8	prothrombin	Oryctolagus cuniculus	294-302
14599363-6	2002	However, a subset of agonists (tinyatoxin, gingerol, and zingerone) was approximately 10-fold more potent for rVR1 compared to hVR1.	gingerol	43-51	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-114
14599363-6	2002	However, a subset of agonists (tinyatoxin, gingerol, and zingerone) was approximately 10-fold more potent for rVR1 compared to hVR1.	gingerol	43-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-131
8190011-3	1994	The ratio of two isomers formed in the above reaction was about 1:5, suggesting the stereospecific reduction of S-(+)-[6]-gingerol by carbonyl reductase activity present in the postmitochondrial supernatant fraction of rat liver.	gingerol	112-130	dehydrogenase/reductase 4	Rattus norvegicus	134-152
8406230-4	1993	Gingerol was found to facilitate the action of the ATPase.	gingerol	0-8	dynein axonemal heavy chain 8	Homo sapiens	51-57
1394650-5	1992	In contrast, hepatic intoxication with CCl4 elevated the plasma concentration of [6]-gingerol at the terminal phase.	gingerol	81-93	C-C motif chemokine ligand 4	Rattus norvegicus	39-43
1394650-7	1992	The extent of [6]-gingerol bound to serum protein was more than 90% and was affected very slightly by the CCl4-intoxication.	gingerol	18-26	C-C motif chemokine ligand 4	Rattus norvegicus	106-110
34688150-4	2021	The binding affinity of 6-gingerol and IFN-gamma was the basis for docking conformations.	gingerol	24-34	interferon gamma	Mus musculus	39-48
33806914-5	2021	The obtained results revealed that curcumin, 6-gingerol, capsaicin, and resveratrol represent potential PDE4D inhibitors; however, the predicted binding free energies of 6-gingerol, capsaicin, and resveratrol were less negative than in the case of curcumin, which exhibited the highest inhibitory potency in comparison with a positive control rolipram.	gingerol	45-55	phosphodiesterase 4D	Homo sapiens	104-109
33806914-5	2021	The obtained results revealed that curcumin, 6-gingerol, capsaicin, and resveratrol represent potential PDE4D inhibitors; however, the predicted binding free energies of 6-gingerol, capsaicin, and resveratrol were less negative than in the case of curcumin, which exhibited the highest inhibitory potency in comparison with a positive control rolipram.	gingerol	170-180	phosphodiesterase 4D	Homo sapiens	104-109
33806914-9	2021	The uncovered molecular inhibitory mechanisms of four investigated natural polyphenols, curcumin, 6-gingerol, capsaicin, and resveratrol, form the basis for the design of novel PDE4D inhibitors for the treatment of Alzheimer"s disease with a potentially wider therapeutic window and fewer adverse side effects.	gingerol	98-108	phosphodiesterase 4D	Homo sapiens	177-182
33808773-0	2021	Nutraceutical Screening in a Zebrafish Model of Muscular Dystrophy: Gingerol as a Possible Food Aid.	gingerol	68-76	activation-induced cytidine deaminase	Danio rerio	96-99
34818732-0	2022	The interaction between bovine serum albumin and (6)-,(8)- and (10)-gingerol: An effective strategy to improve the solubility and stability of gingerol.	gingerol	143-151	albumin	Homo sapiens	31-44
34818732-1	2022	In this study, the binding mechanism between bovine serum albumin (BSA) and three gingerols ((6)-, (8)- and (10)-gingerol) was evaluated to explore an effective strategy for improving solubility and stability of gingerols.	gingerol	82-91	albumin	Homo sapiens	52-65
34818732-1	2022	In this study, the binding mechanism between bovine serum albumin (BSA) and three gingerols ((6)-, (8)- and (10)-gingerol) was evaluated to explore an effective strategy for improving solubility and stability of gingerols.	gingerol	212-221	albumin	Homo sapiens	52-65
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	peroxisome proliferator activated receptor gamma	Mus musculus	208-217
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	219-229
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	fatty acid binding protein 4, adipocyte	Mus musculus	231-236
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	adiponectin, C1Q and collagen domain containing	Mus musculus	241-252
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	toll-like receptor 3	Mus musculus	262-266
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	interleukin 6	Mus musculus	267-271
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	Janus kinase 1	Mus musculus	272-276
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	signal transducer and activator of transcription 3	Mus musculus	277-282
34896967-11	2022	Moreover, 6-gingerol treatment suppressed the expressions of IL-1beta and CD68 in the liver and AKT/INSR/IRS-1 in epididymal WAT.	gingerol	10-20	interleukin 1 alpha	Mus musculus	61-69
34896967-11	2022	Moreover, 6-gingerol treatment suppressed the expressions of IL-1beta and CD68 in the liver and AKT/INSR/IRS-1 in epididymal WAT.	gingerol	10-20	CD68 antigen	Mus musculus	74-78
34896967-11	2022	Moreover, 6-gingerol treatment suppressed the expressions of IL-1beta and CD68 in the liver and AKT/INSR/IRS-1 in epididymal WAT.	gingerol	10-20	thymoma viral proto-oncogene 1	Mus musculus	96-99
34896967-11	2022	Moreover, 6-gingerol treatment suppressed the expressions of IL-1beta and CD68 in the liver and AKT/INSR/IRS-1 in epididymal WAT.	gingerol	10-20	insulin receptor	Mus musculus	100-104
34896967-11	2022	Moreover, 6-gingerol treatment suppressed the expressions of IL-1beta and CD68 in the liver and AKT/INSR/IRS-1 in epididymal WAT.	gingerol	10-20	insulin receptor substrate 1	Mus musculus	105-110
34934427-3	2022	Therefore, the present study demonstrated the anti-asthmatic effects of SHO and GIN on the T-helper (Th) 2 cell-mediated allergic response pathway in an ovalbumin (OVA)-induced asthma mouse model.	gingerol	80-83	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	153-162
34934427-3	2022	Therefore, the present study demonstrated the anti-asthmatic effects of SHO and GIN on the T-helper (Th) 2 cell-mediated allergic response pathway in an ovalbumin (OVA)-induced asthma mouse model.	gingerol	80-83	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	164-167
34962339-0	2022	Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis.	gingerol	0-8	microRNA 210	Mus musculus	78-85
34962339-0	2022	Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis.	gingerol	0-8	brain derived neurotrophic factor	Mus musculus	86-119
34962339-4	2022	This investigation aimed to determine whether gingerol plays a neuroprotective role in cerebral ischemia via the miR-210/BDNF axis.	gingerol	46-54	microRNA 210	Mus musculus	113-120
34962339-4	2022	This investigation aimed to determine whether gingerol plays a neuroprotective role in cerebral ischemia via the miR-210/BDNF axis.	gingerol	46-54	brain derived neurotrophic factor	Mus musculus	121-125
34962339-10	2022	Gingerol increased Bcl-2, BDNF, and TrkB levels and reduced Bax and cleaved caspase 3 levels after hypoxia/reoxygenation.	gingerol	0-8	B cell leukemia/lymphoma 2	Mus musculus	19-24
34962339-10	2022	Gingerol increased Bcl-2, BDNF, and TrkB levels and reduced Bax and cleaved caspase 3 levels after hypoxia/reoxygenation.	gingerol	0-8	brain derived neurotrophic factor	Mus musculus	26-30
34962339-10	2022	Gingerol increased Bcl-2, BDNF, and TrkB levels and reduced Bax and cleaved caspase 3 levels after hypoxia/reoxygenation.	gingerol	0-8	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	36-40
34962339-10	2022	Gingerol increased Bcl-2, BDNF, and TrkB levels and reduced Bax and cleaved caspase 3 levels after hypoxia/reoxygenation.	gingerol	0-8	BCL2-associated X protein	Mus musculus	60-63
34962339-11	2022	Gingerol evoked decreased expression of miR-210.	gingerol	0-8	microRNA 210	Mus musculus	40-47
34962339-13	2022	Additionally, the miR-210 mimic reversed changes induced by gingerol.	gingerol	60-68	microRNA 210	Mus musculus	18-25
34962339-17	2022	Gingerol ameliorated hypoxia/reoxygenation-stimulated neuronal damage by regulating the miR-210/BDNF axis, indicating that gingerol is worthy of further application in cerebral ischemia therapy.	gingerol	0-8	microRNA 210	Mus musculus	88-95
34962339-17	2022	Gingerol ameliorated hypoxia/reoxygenation-stimulated neuronal damage by regulating the miR-210/BDNF axis, indicating that gingerol is worthy of further application in cerebral ischemia therapy.	gingerol	0-8	brain derived neurotrophic factor	Mus musculus	96-100
34962339-17	2022	Gingerol ameliorated hypoxia/reoxygenation-stimulated neuronal damage by regulating the miR-210/BDNF axis, indicating that gingerol is worthy of further application in cerebral ischemia therapy.	gingerol	123-131	microRNA 210	Mus musculus	88-95
34962339-17	2022	Gingerol ameliorated hypoxia/reoxygenation-stimulated neuronal damage by regulating the miR-210/BDNF axis, indicating that gingerol is worthy of further application in cerebral ischemia therapy.	gingerol	123-131	brain derived neurotrophic factor	Mus musculus	96-100
34599795-0	2021	6-Gingerol and semisynthetic 6-Gingerdione counteract oxidative stress induced by ROS in zebrafish.	gingerol	0-10	endothelin receptor Ba	Danio rerio	82-85
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	negative elongation factor complex member C/D, Th1l	Mus musculus	200-203
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	interleukin 12b	Mus musculus	223-231
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	interferon gamma	Mus musculus	233-242
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	tumor necrosis factor	Mus musculus	248-258
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	nitric oxide synthase 2, inducible	Mus musculus	261-265
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	signal transducer and activator of transcription 1	Mus musculus	294-299
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	FBJ osteosarcoma oncogene	Mus musculus	301-306
34688150-5	2021	6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1).	gingerol	0-10	ELK1, member of ETS oncogene family	Mus musculus	312-317
34688150-10	2021	In conclusion, 6-gingerol with amphotericin B synergistically exerted anti-leishmanial activity in vitro and in vivo and potentiated macrophages" leishmanicidal activity, modulated Th1- and Th2-related phenotypes improved the histopathological changes in the BALB/c mice infected with L. major.	gingerol	15-25	negative elongation factor complex member C/D, Th1l	Mus musculus	181-184
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	24-34	mitogen-activated protein kinase 9	Rattus norvegicus	119-123
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	24-34	mitogen-activated protein kinase 8	Rattus norvegicus	124-127
34783140-0	2022	Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation.	gingerol	22-32	mitogen-activated protein kinase 9	Rattus norvegicus	108-112
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	24-34	mitogen-activated protein kinase 9	Rattus norvegicus	130-138
34783140-0	2022	Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation.	gingerol	22-32	mitogen-activated protein kinase 8	Rattus norvegicus	113-116
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	83-93	mitogen-activated protein kinase 9	Rattus norvegicus	119-123
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	83-93	mitogen-activated protein kinase 8	Rattus norvegicus	124-127
34783140-7	2022	Also, pretreatment with 6-gingerol at 2.5 and 5 microM increased survivin whereas, 6-gingerol at 2.5 microM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control.	gingerol	83-93	mitogen-activated protein kinase 9	Rattus norvegicus	130-138
34537481-11	2021	In addition, 6-Gingerol significantly reduced NLRP3 inflammasome-derived inflammation and neuronal apoptosis and upregulated autophagy.	gingerol	13-23	NLR family, pyrin domain containing 3	Rattus norvegicus	46-51
34804985-10	2021	The induction of PTEN also mediated the downregulation of microRNAs miR-20b, miR-21, and miR-130b to result in PD-L1 suppression by 6-gingerol.	gingerol	132-142	microRNA 20b	Homo sapiens	68-75
34804985-10	2021	The induction of PTEN also mediated the downregulation of microRNAs miR-20b, miR-21, and miR-130b to result in PD-L1 suppression by 6-gingerol.	gingerol	132-142	microRNA 21	Homo sapiens	77-83
34804985-10	2021	The induction of PTEN also mediated the downregulation of microRNAs miR-20b, miR-21, and miR-130b to result in PD-L1 suppression by 6-gingerol.	gingerol	132-142	microRNA 130b	Homo sapiens	89-97
34804985-10	2021	The induction of PTEN also mediated the downregulation of microRNAs miR-20b, miR-21, and miR-130b to result in PD-L1 suppression by 6-gingerol.	gingerol	132-142	CD274 molecule	Homo sapiens	111-116
34804985-11	2021	Hence, 6-gingerol may be a promising candidate to target CSCs by regulating PTEN-mediated PD-L1 expression.	gingerol	7-17	phosphatase and tensin homolog	Homo sapiens	76-80
34804985-11	2021	Hence, 6-gingerol may be a promising candidate to target CSCs by regulating PTEN-mediated PD-L1 expression.	gingerol	7-17	CD274 molecule	Homo sapiens	90-95
34537481-0	2021	6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.	gingerol	0-10	NLR family, pyrin domain containing 3	Rattus norvegicus	79-84
34537481-0	2021	6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.	gingerol	0-10	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
34804985-0	2021	Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells.	gingerol	80-90	phosphatase and tensin homolog	Homo sapiens	99-103
34804985-0	2021	Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells.	gingerol	80-90	CD274 molecule	Homo sapiens	114-119
34804985-6	2021	Our results suggested an inhibition of CSC marker expression and Wnt/beta-catenin signaling by 6-gingerol in NCCIT and NTERA-2 cells.	gingerol	95-105	catenin beta 1	Homo sapiens	69-81
34804985-8	2021	Furthermore, 6-gingerol inhibited iron metabolism and induced PTEN, which both played vital roles in the induction of cell death.	gingerol	13-23	phosphatase and tensin homolog	Homo sapiens	62-66
34804985-10	2021	The induction of PTEN also mediated the downregulation of microRNAs miR-20b, miR-21, and miR-130b to result in PD-L1 suppression by 6-gingerol.	gingerol	132-142	phosphatase and tensin homolog	Homo sapiens	17-21
34697150-0	2021	(6)-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway.	gingerol	0-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	78-82
34697150-0	2021	(6)-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway.	gingerol	0-12	AKT serine/threonine kinase 1	Homo sapiens	103-106
34697150-0	2021	(6)-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway.	gingerol	0-12	mechanistic target of rapamycin kinase	Homo sapiens	107-111
34697150-7	2021	(6)-Gingerol also inhibited oral cancer cell migration and invasion by up-regulating E-cadherin and down-regulating N-cadherin and vimentin.	gingerol	0-12	cadherin 1	Homo sapiens	85-95
34697150-7	2021	(6)-Gingerol also inhibited oral cancer cell migration and invasion by up-regulating E-cadherin and down-regulating N-cadherin and vimentin.	gingerol	0-12	cadherin 2	Homo sapiens	116-126
34697150-7	2021	(6)-Gingerol also inhibited oral cancer cell migration and invasion by up-regulating E-cadherin and down-regulating N-cadherin and vimentin.	gingerol	0-12	vimentin	Homo sapiens	131-139
34697150-8	2021	Moreover, (6)-gingerol induced the activation of AMPK and suppressed the AKT/mTOR signaling pathway in YD10B and Ca9-22 cells.	gingerol	10-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	49-53
34697150-8	2021	Moreover, (6)-gingerol induced the activation of AMPK and suppressed the AKT/mTOR signaling pathway in YD10B and Ca9-22 cells.	gingerol	10-22	AKT serine/threonine kinase 1	Homo sapiens	73-76
34697150-8	2021	Moreover, (6)-gingerol induced the activation of AMPK and suppressed the AKT/mTOR signaling pathway in YD10B and Ca9-22 cells.	gingerol	10-22	mechanistic target of rapamycin kinase	Homo sapiens	77-81
34697150-9	2021	CONCLUSION: (6)-Gingerol exerts anticancer activity by activating AMPK and suppressing the AKT/mTOR signaling pathway in oral cancer cells.	gingerol	12-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	66-70
34697150-9	2021	CONCLUSION: (6)-Gingerol exerts anticancer activity by activating AMPK and suppressing the AKT/mTOR signaling pathway in oral cancer cells.	gingerol	12-24	AKT serine/threonine kinase 1	Homo sapiens	91-94
34697150-9	2021	CONCLUSION: (6)-Gingerol exerts anticancer activity by activating AMPK and suppressing the AKT/mTOR signaling pathway in oral cancer cells.	gingerol	12-24	mechanistic target of rapamycin kinase	Homo sapiens	95-99
34537481-0	2021	6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.	gingerol	0-10	Fas associated factor 1	Rattus norvegicus	124-128
34537481-12	2021	The autophagy inhibitor 3-MA rescued the effects of 6-Gingerol on the NLRP3 inflammasome and apoptosis.	gingerol	52-62	NLR family, pyrin domain containing 3	Rattus norvegicus	70-75
34537481-13	2021	Moreover, the findings illustrated that 6-Gingerol inhibited autophagy-induced NLRP3 inflammasome activation and apoptosis through the dissociation of TRPV1 from FAF1.	gingerol	40-50	NLR family, pyrin domain containing 3	Rattus norvegicus	79-84
34537481-13	2021	Moreover, the findings illustrated that 6-Gingerol inhibited autophagy-induced NLRP3 inflammasome activation and apoptosis through the dissociation of TRPV1 from FAF1.	gingerol	40-50	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	151-156
34537481-13	2021	Moreover, the findings illustrated that 6-Gingerol inhibited autophagy-induced NLRP3 inflammasome activation and apoptosis through the dissociation of TRPV1 from FAF1.	gingerol	40-50	Fas associated factor 1	Rattus norvegicus	162-166
34537481-14	2021	CONCLUSION: In brief, 6-Gingerol exerts antiapoptotic and anti-inflammatory effects via TRPV1/FAF1 complex dissociation-mediated autophagy during cerebral I/R injury.	gingerol	22-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
34537481-14	2021	CONCLUSION: In brief, 6-Gingerol exerts antiapoptotic and anti-inflammatory effects via TRPV1/FAF1 complex dissociation-mediated autophagy during cerebral I/R injury.	gingerol	22-32	Fas associated factor 1	Rattus norvegicus	94-98
34917289-7	2021	Conclusion: According to obtained results, gingerol may improve hippocampal BDNF and NGF levels in rats exposed to AuNPs, probably by reducing apoptosis and oxidative DNA damage.	gingerol	43-51	brain-derived neurotrophic factor	Rattus norvegicus	76-80
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	gingerol	308-316	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	gingerol	308-316	angiotensin converting enzyme 2	Homo sapiens	225-229
34299361-9	2021	Molecular docking to the human NR2B-containing N-methyl-D-aspartate (NMDA) receptor suggests that 6-GIN might act as an inhibitor and interact with the amino terminal domain, the glutamate-binding site, as well as within the ion channel of the NR2B-containing NMDA receptor.	gingerol	98-103	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	31-35
34299361-9	2021	Molecular docking to the human NR2B-containing N-methyl-D-aspartate (NMDA) receptor suggests that 6-GIN might act as an inhibitor and interact with the amino terminal domain, the glutamate-binding site, as well as within the ion channel of the NR2B-containing NMDA receptor.	gingerol	98-103	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	244-248
34917289-2	2021	Given the antioxidant properties of Gingerol (GING), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), DNA oxidative damage, and the amount of Bax and Bcl2 apoptosis indices of rats exposed to AuNPs.	gingerol	108-118	brain-derived neurotrophic factor	Rattus norvegicus	144-177
34630084-10	2021	In terms of mechanism, we found that 6-Gingerol decreased histone H3K27me3 levels, activated AKT pathway and inhibited the activation of ERK and NF-kappaB pathway at 3 days post-HIBI.	gingerol	37-47	thymoma viral proto-oncogene 1	Mus musculus	93-96
34630084-10	2021	In terms of mechanism, we found that 6-Gingerol decreased histone H3K27me3 levels, activated AKT pathway and inhibited the activation of ERK and NF-kappaB pathway at 3 days post-HIBI.	gingerol	37-47	mitogen-activated protein kinase 1	Mus musculus	137-140
34630084-11	2021	Taken together, our data clearly indicate that 6-Gingerol plays a neuroprotective role against HIBI by epigenetic modification and regulation of AKT, ERK, and NF-kappaB pathways, inhibiting inflammatory responses and reducing cell death.	gingerol	47-57	thymoma viral proto-oncogene 1	Mus musculus	145-148
34630084-11	2021	Taken together, our data clearly indicate that 6-Gingerol plays a neuroprotective role against HIBI by epigenetic modification and regulation of AKT, ERK, and NF-kappaB pathways, inhibiting inflammatory responses and reducing cell death.	gingerol	47-57	mitogen-activated protein kinase 1	Mus musculus	150-153
34917289-7	2021	Conclusion: According to obtained results, gingerol may improve hippocampal BDNF and NGF levels in rats exposed to AuNPs, probably by reducing apoptosis and oxidative DNA damage.	gingerol	43-51	nerve growth factor	Rattus norvegicus	85-88
35429380-10	2022	The results of molecular docking show that the binding energy of gingerol derivatives has good binding activity with PI3K and Akt.	gingerol	65-73	AKT serine/threonine kinase 1	Homo sapiens	126-129
34139323-0	2021	6-gingerol ameliorates hepatic steatosis via HNF4alpha/miR-467b-3p/GPAT1 cascade.	gingerol	0-10	hepatic nuclear factor 4, alpha	Mus musculus	45-54
34139323-0	2021	6-gingerol ameliorates hepatic steatosis via HNF4alpha/miR-467b-3p/GPAT1 cascade.	gingerol	0-10	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	67-72
35569350-0	2022	Protective mechanisms of 10-gingerol against myocardial ischemia may involve activation of JAK2/STAT3 pathway and regulation of Ca2+ homeostasis.	gingerol	25-36	Janus kinase 2	Rattus norvegicus	91-95
35569350-0	2022	Protective mechanisms of 10-gingerol against myocardial ischemia may involve activation of JAK2/STAT3 pathway and regulation of Ca2+ homeostasis.	gingerol	25-36	signal transducer and activator of transcription 3	Rattus norvegicus	96-101
35569350-11	2022	Our results suggest that 10-Gin exerts cardioprotective effects on MI in vivo and in vitro in connection with the inhibition of oxidative stress and apoptosis via activation of the JAK2/STAT3 signalling pathway, and regulation of Ca2+ homeostasis by LTCCs.	gingerol	25-31	Janus kinase 2	Rattus norvegicus	181-185
35569350-11	2022	Our results suggest that 10-Gin exerts cardioprotective effects on MI in vivo and in vitro in connection with the inhibition of oxidative stress and apoptosis via activation of the JAK2/STAT3 signalling pathway, and regulation of Ca2+ homeostasis by LTCCs.	gingerol	25-31	signal transducer and activator of transcription 3	Rattus norvegicus	186-191
35429380-13	2022	CONCLUSIONS: The results of network pharmacology and experimental validation suggest that gingerol derivatives and compound gingerol can act against liver cancer by acting on the PI3K-Akt signalling pathway.	gingerol	90-98	AKT serine/threonine kinase 1	Homo sapiens	184-187
35429380-13	2022	CONCLUSIONS: The results of network pharmacology and experimental validation suggest that gingerol derivatives and compound gingerol can act against liver cancer by acting on the PI3K-Akt signalling pathway.	gingerol	124-132	AKT serine/threonine kinase 1	Homo sapiens	184-187
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	synaptotagmin 1	Rattus norvegicus	158-161
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	heme oxygenase 1	Rattus norvegicus	189-193
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	199-209
35245652-12	2022	However, treatment with specific Nrf2 inhibitor blunted the activation of Nrf2 signaling and removed the protective effects of 6-gingerol.	gingerol	127-137	NFE2 like bZIP transcription factor 2	Rattus norvegicus	33-37
35245652-13	2022	These experiments provide evidence that 6-gingerol exerts cytoprotective effects, which may be associated with the regulation of oxidative stress and apoptosis, potentially through activating the Nrf2 pathway and inhibiting the p38/NF-kappaB pathways.	gingerol	40-50	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-200
35245652-13	2022	These experiments provide evidence that 6-gingerol exerts cytoprotective effects, which may be associated with the regulation of oxidative stress and apoptosis, potentially through activating the Nrf2 pathway and inhibiting the p38/NF-kappaB pathways.	gingerol	40-50	mitogen activated protein kinase 14	Rattus norvegicus	228-231
35527779-9	2022	Furthermore, 6-Gingerol significantly decreased the protein expression levels of glutathione (GSH) peroxidase 4 and nuclear factor erythroid 2-related factor 2 in prostate cancer cells.	gingerol	13-23	NFE2 like bZIP transcription factor 2	Homo sapiens	81-159
35077967-6	2022	Of these, (10)-gingerol, angelicin, corticosterone, eupatilin, etofenprox, oxadixyl, and tretinoin were identified as novel AhR agonists.	gingerol	10-23	aryl hydrocarbon receptor	Homo sapiens	124-127
35511715-1	2022	OBJECTIVES: Gingerols are bioactive compounds derived from ginger, our experiment investigates the effects of 6-, 8- and 10-Gin on the human ether-a-go-go-related gene (hERG) K+ channels by using patch clamp technology.	gingerol	12-21	ETS transcription factor ERG	Homo sapiens	169-173
35408505-0	2022	Reduced HIF-1alpha Stability Induced by 6-Gingerol Inhibits Lung Cancer Growth through the Induction of Cell Death.	gingerol	40-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-18
35408505-9	2022	Interestingly, we found that 6-gingerol treatment suppressed activation of the transcription factor HIF-1alpha by downregulating HSP90 under both normoxic and hypoxic conditions.	gingerol	29-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
35408505-9	2022	Interestingly, we found that 6-gingerol treatment suppressed activation of the transcription factor HIF-1alpha by downregulating HSP90 under both normoxic and hypoxic conditions.	gingerol	29-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	129-134
35408505-11	2022	Both in vitro and in vivo analyses showed the inhibition of metastasis through HIF-1alpha/HSP90 after 6-gingerol treatment.	gingerol	102-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
35408505-12	2022	In summary, our study demonstrates that 6-gingerol suppresses proliferation and blocks the nuclear translocation of HIF-1alpha and activation of the EMT pathway.	gingerol	40-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	alanyl aminopeptidase, membrane	Rattus norvegicus	99-102
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	adiponectin receptor 1	Rattus norvegicus	104-111
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	PPARG coactivator 1 alpha	Rattus norvegicus	113-123
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	182-186
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	AKT serine/threonine kinase 1	Rattus norvegicus	202-205
35381876-0	2022	Editorial Expression of Concern for: Induction of apoptosis by (6)-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B(a)P-induced mouse skin tumorigenesis.	gingerol	63-75	transformation related protein 53, pseudogene	Mus musculus	110-113
35245652-0	2022	6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-kappaB pathway in H9c2 cells.	gingerol	0-10	mitogen activated protein kinase 14	Rattus norvegicus	73-76
35245652-0	2022	6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-kappaB pathway in H9c2 cells.	gingerol	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81
35245652-0	2022	6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-kappaB pathway in H9c2 cells.	gingerol	0-10	heme oxygenase 1	Rattus norvegicus	82-86
35245652-0	2022	6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-kappaB pathway in H9c2 cells.	gingerol	0-10	mitogen activated protein kinase 14	Rattus norvegicus	91-94
35245652-3	2022	The purpose of this study was to characterize the effect of 6-gingerol on the p38/Nrf2/HO-1 and p38/NF-kappaB signaling pathway, as a possible means of combating hypoxia-related oxidative stress.	gingerol	60-70	mitogen activated protein kinase 14	Rattus norvegicus	78-81
35245652-3	2022	The purpose of this study was to characterize the effect of 6-gingerol on the p38/Nrf2/HO-1 and p38/NF-kappaB signaling pathway, as a possible means of combating hypoxia-related oxidative stress.	gingerol	60-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
35245652-3	2022	The purpose of this study was to characterize the effect of 6-gingerol on the p38/Nrf2/HO-1 and p38/NF-kappaB signaling pathway, as a possible means of combating hypoxia-related oxidative stress.	gingerol	60-70	heme oxygenase 1	Rattus norvegicus	87-91
35245652-3	2022	The purpose of this study was to characterize the effect of 6-gingerol on the p38/Nrf2/HO-1 and p38/NF-kappaB signaling pathway, as a possible means of combating hypoxia-related oxidative stress.	gingerol	60-70	mitogen activated protein kinase 14	Rattus norvegicus	96-99
35245652-7	2022	The antioxidative property of 6-gingerol was measured by estimating the activities of superoxide dismutase, catalase, glutathione and glutathione disulfide.	gingerol	30-40	catalase	Rattus norvegicus	108-116
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	mitogen activated protein kinase 14	Rattus norvegicus	52-55
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	mitogen activated protein kinase 14	Rattus norvegicus	56-59
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	synaptotagmin 1	Rattus norvegicus	69-72
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	synaptotagmin 1	Rattus norvegicus	80-83
35245652-11	2022	Furthermore, 6-gingerol was able to down-regulate p-p38/p38, nuclear p65, total p65 and Keap1 expression induced by CoCl2 stimulation and increased cytoplasm p65, nuclear Nrf2, total Nrf2, HO-1, and HIF-1alpha expression.	gingerol	13-23	Kelch-like ECH-associated protein 1	Rattus norvegicus	88-93
35527779-7	2022	6-Gingerol also induced autophagy by significantly increasing LC3B-II and Beclin-1 protein expression levels in prostate cancer cells.	gingerol	0-10	beclin 1	Homo sapiens	74-82
35571130-0	2022	Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1alpha Signaling Pathway.	gingerol	22-32	sirtuin 1	Mus musculus	92-97
35571130-0	2022	Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1alpha Signaling Pathway.	gingerol	22-32	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	98-108
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	gingerol	312-320	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	gingerol	312-320	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	159-164
35474281-9	2022	The larger exposure (the mean AUC0-t of ginsenoside Re, ginsenoside Rg1, ginsenoside Rb1, and 6-gingerol were increased by 50.93, 141.90, 3.68, and 37.25%, respectively) and slower elimination (the CLz/F of ginsenoside Re, ginsenoside Rg1, and 6-gingerol were decreased by 52.94, 83.64, and 32.18%, respectively) were observed in ulcerative colitis rats.	gingerol	244-254	RB transcriptional corepressor 1	Rattus norvegicus	85-88
35566044-7	2022	After 72 h of incubation, the mitochondrial activity showed that the combination of 5 nM Paclitaxel with 10 microM 6-Gingerol led to the same decrease in viability as the use of 20 nM Paclitaxel alone; 10 microM 6-Gingerol led to an enhancement of caspase 7 activity, with the highest activity observed after 24 h of incubation.	gingerol	115-125	caspase 7	Homo sapiens	248-257
35566044-8	2022	A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2.	gingerol	34-44	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
35566044-8	2022	A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2.	gingerol	34-44	tumor protein p53	Homo sapiens	96-100
35566044-8	2022	A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2.	gingerol	34-44	BCL2 apoptosis regulator	Homo sapiens	126-131
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	alanyl aminopeptidase, membrane	Rattus norvegicus	274-277
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	tumor necrosis factor	Rattus norvegicus	260-269
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	adiponectin receptor 1	Rattus norvegicus	299-306
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	349-353
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	interleukin 6	Rattus norvegicus	281-285
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	PPARG coactivator 1 alpha	Rattus norvegicus	354-364
33758383-0	2021	6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy.	gingerol	0-10	microRNA 143	Mus musculus	85-92
34853442-0	2022	Correction: 6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy.	gingerol	12-22	microRNA 143	Homo sapiens	97-104
34853442-0	2022	Correction: 6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy.	gingerol	12-22	autophagy related 7	Homo sapiens	105-109
3210448-1	1988	The suppression of spontaneous Ca2+ spikes and isometric contractions by gingerols and their chemically related compounds was examined using the single sucrose gap method.	gingerol	73-82	carbonic anhydrase 2	Mus musculus	31-34
3210448-3	1988	The most potent analogues for Ca2+ spike suppression were (+/-)-[6]-gingerol (0.3 mM) and (+/-)-yakuchinone-A (0.3 mM).	gingerol	58-76	carbonic anhydrase 2	Mus musculus	30-33
3210448-6	1988	These results suggest that the inhibition of spontaneous contraction induced by (+/-)-[6]-gingerol, but not by (+/-)-[8]-gingerol, is due to the Ca2+ spike suppression.	gingerol	80-98	carbonic anhydrase 2	Mus musculus	145-148
33652057-11	2021	Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties.	gingerol	49-58	butyrylcholinesterase	Homo sapiens	186-200
33925065-0	2021	Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells.	gingerol	31-41	tumor protein p53	Homo sapiens	45-48
33925065-7	2021	6-Gingerol induced cellular and mitochondrial ROS that elevated DDR through ataxia-telangiectasia mutated and p53 activation.	gingerol	0-10	tumor protein p53	Homo sapiens	110-113
33925065-8	2021	6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c.	gingerol	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96
33925065-8	2021	6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c.	gingerol	0-10	BCL2 apoptosis regulator	Homo sapiens	97-102
33925065-8	2021	6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c.	gingerol	0-10	cytochrome c, somatic	Homo sapiens	124-136
33925065-10	2021	EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells.	gingerol	91-101	epidermal growth factor receptor	Homo sapiens	0-4
33925065-10	2021	EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells.	gingerol	91-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	5-8
33925065-10	2021	EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells.	gingerol	91-101	tumor protein p53	Homo sapiens	110-113
2761127-5	1989	The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE.	gingerol	4-13	prostaglandin I receptor (IP)	Mus musculus	104-108
2761127-5	1989	The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE.	gingerol	4-13	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	117-120
33561649-11	2021	In contrast, gingerol has shown strong interactions with spike protein, and RdRp and quercetin with main protease (Mpro) of SARS-CoV-2.	gingerol	13-21	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
33561649-11	2021	In contrast, gingerol has shown strong interactions with spike protein, and RdRp and quercetin with main protease (Mpro) of SARS-CoV-2.	gingerol	13-21	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	76-80
33561649-11	2021	In contrast, gingerol has shown strong interactions with spike protein, and RdRp and quercetin with main protease (Mpro) of SARS-CoV-2.	gingerol	13-21	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	115-119
33758383-0	2021	6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy.	gingerol	0-10	autophagy related 7	Mus musculus	93-97
33461160-0	2021	6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARgamma/NF-kappaBsignalling pathway in rats.	gingerol	0-10	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	118-127
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	dendrocyte expressed seven transmembrane protein	Mus musculus	152-200
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	matrix metallopeptidase 9	Mus musculus	206-231
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	matrix metallopeptidase 9	Mus musculus	233-237
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	cathepsin K	Danio rerio	282-293
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	cathepsin K	Danio rerio	295-299
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	matrix metallopeptidase 2	Danio rerio	302-306
33748100-7	2021	Gene expression analysis revealed that 10-gingerol suppressed osteoclast markers in RAW264.7 cells [osteoclast-associated immunoglobulin-like receptor, dendrocyte-expressed seven transmembrane protein, and matrix metallopeptidase-9 (Mmp9)] and zebrafish scales [osteoclast-specific cathepsin K (CTSK), mmp2, and mmp9].	gingerol	39-50	matrix metallopeptidase 9	Danio rerio	312-316
33748100-9	2021	In addition, 10-gingerol inhibited CTSK activity under cell-free conditions.	gingerol	13-24	cathepsin K	Mus musculus	35-39
33461160-6	2021	Furthermore, GW9662, a specific PPARgamma inhibitor, was demonstrated to activatethe NF-kappaB pathway and cancele the protective role of 6-gingerol in VILI.	gingerol	138-148	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	32-41
33461160-7	2021	This indicates that 6-gingerol exerted anti-inflammatory and antioxidative stress effects in VILI by activating PPARgamma and inhibiting the NF-kappaBsignalling pathway.	gingerol	20-30	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	112-121
33461160-4	2021	In the study, we found that pre-treatment with 6-gingerol significantly improved the histological changes and pulmonary oedema, inhibited neutrophil accumulation and the release of early pro-inflammatory cytokines and MPO, and reduced oxidative stress reactions after high MV.	gingerol	47-57	myeloperoxidase	Rattus norvegicus	218-221
33461160-5	2021	Moreover, 6-gingerol treatment also increased PPARgamma expression and decreased NF-kappaB activation in rats subjected to high MV.	gingerol	10-20	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	46-55
32926756-6	2021	Moreover, reduction in MMP2, Slug, and Vimentin protein levels was observed following 6-gingerol treatment of 786-O and ACHN cells.	gingerol	86-96	matrix metallopeptidase 2	Homo sapiens	23-27
33462378-7	2021	In the in vitro study, we showed that treatment with 6-gingerol (20 muM) blocked PE-induced-cardiomyocyte hypertrophy and TGF-beta-induced cardiac fibroblast activation.	gingerol	53-63	transforming growth factor alpha	Mus musculus	122-130
33462378-8	2021	Furthermore, 6-gingerol treatment significantly decreased mitogen-activated protein kinase p38 (p38) phosphorylation in response to pressure overload in vivo and extracellular stimuli in vitro, which was upregulated in the absence of 6-gingerol treatment.	gingerol	13-23	mitogen-activated protein kinase 14	Mus musculus	91-94
33462378-8	2021	Furthermore, 6-gingerol treatment significantly decreased mitogen-activated protein kinase p38 (p38) phosphorylation in response to pressure overload in vivo and extracellular stimuli in vitro, which was upregulated in the absence of 6-gingerol treatment.	gingerol	13-23	mitogen-activated protein kinase 14	Mus musculus	96-99
33462378-9	2021	Moreover, transfection with mitogen-activated protein kinase kinase 6 expressing adenoviruses (Ad-MKK6), which specifically activated p38, abolished the protective effects of 6-gingerol in both in vitro and in vivo models.	gingerol	175-185	mitogen-activated protein kinase kinase 6	Mus musculus	28-69
33462378-9	2021	Moreover, transfection with mitogen-activated protein kinase kinase 6 expressing adenoviruses (Ad-MKK6), which specifically activated p38, abolished the protective effects of 6-gingerol in both in vitro and in vivo models.	gingerol	175-185	mitogen-activated protein kinase kinase 6	Mus musculus	98-102
33462378-9	2021	Moreover, transfection with mitogen-activated protein kinase kinase 6 expressing adenoviruses (Ad-MKK6), which specifically activated p38, abolished the protective effects of 6-gingerol in both in vitro and in vivo models.	gingerol	175-185	mitogen-activated protein kinase 14	Mus musculus	134-137
33462378-10	2021	In conclusion, 6-gingerol improves cardiac function and alleviates cardiac remodeling induced by pressure overload in a p38-dependent manner.	gingerol	15-25	mitogen-activated protein kinase 14	Mus musculus	120-123
32926756-6	2021	Moreover, reduction in MMP2, Slug, and Vimentin protein levels was observed following 6-gingerol treatment of 786-O and ACHN cells.	gingerol	86-96	snail family transcriptional repressor 2	Homo sapiens	29-33
32926756-6	2021	Moreover, reduction in MMP2, Slug, and Vimentin protein levels was observed following 6-gingerol treatment of 786-O and ACHN cells.	gingerol	86-96	vimentin	Homo sapiens	39-47
32926756-8	2021	6-Gingerol increased yes-associated protein (YAP)ser127 phosphorylation and reduced YAP levels in cell nuclei.	gingerol	0-10	Yes1 associated transcriptional regulator	Homo sapiens	45-48
32926756-8	2021	6-Gingerol increased yes-associated protein (YAP)ser127 phosphorylation and reduced YAP levels in cell nuclei.	gingerol	0-10	Yes1 associated transcriptional regulator	Homo sapiens	84-87
32926756-12	2021	Immunofluorescence images showed that 6-gingerol decreased YAP levels, leading to disordered F-actin and a reduction in cell lamellipodia.	gingerol	38-48	Yes1 associated transcriptional regulator	Homo sapiens	59-62
32737772-6	2020	Interestingly, we also found that [6]-gingerol, an anti-OA drug, could upregulate the protein level of Usp49 and suppress the Wnt/beta-catenin signaling cascade in primary rat chondrocytes.	gingerol	34-46	ubiquitin specific peptidase 49	Rattus norvegicus	103-108
33281606-0	2020	The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro.	gingerol	25-35	ubiquitin specific peptidase 14	Mus musculus	39-70
33281606-10	2020	It was found that the administration of 6-Gingerol decreased the expression of USP14, greatly increased the number of autophagosomes, reactive oxygen species (ROS) and iron concentration, decreased the survival and proliferation rate of A549 cells, and significantly decreased tumor volume and weight.	gingerol	40-50	ubiquitin specific peptidase 14	Mus musculus	79-84
33281606-11	2020	The results indicate that 6-Gingerol inhibits lung cancer cell growth via suppression of USP14 expression and its downstream regulation of autophagy-dependent ferroptosis, revealing the function and efficacy of 6-Gingerol as a therapeutic compound in A549 and its possible mechanism of action.	gingerol	26-36	ubiquitin specific peptidase 14	Mus musculus	89-94
33281606-11	2020	The results indicate that 6-Gingerol inhibits lung cancer cell growth via suppression of USP14 expression and its downstream regulation of autophagy-dependent ferroptosis, revealing the function and efficacy of 6-Gingerol as a therapeutic compound in A549 and its possible mechanism of action.	gingerol	211-221	ubiquitin specific peptidase 14	Mus musculus	89-94
33505603-14	2020	6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.	gingerol	0-5	BCL2 apoptosis regulator	Homo sapiens	21-26
33505603-14	2020	6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.	gingerol	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
33505603-14	2020	6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.	gingerol	0-5	caspase 3	Homo sapiens	59-68
33505603-15	2020	The MMP, Annexin V-FITC/PI flow cytometry and TUNEL assay results further confirmed that 6-GIN treatment significantly inhibited NPMSC apoptosis induced by hydrogen peroxide.	gingerol	89-94	matrix metallopeptidase 13	Homo sapiens	4-7
33505603-15	2020	The MMP, Annexin V-FITC/PI flow cytometry and TUNEL assay results further confirmed that 6-GIN treatment significantly inhibited NPMSC apoptosis induced by hydrogen peroxide.	gingerol	89-94	annexin A5	Homo sapiens	9-18
33505603-16	2020	6-GIN treatment promoted extracellular matrix (ECM) expression by reducing the oxidative stress injury-induced increase in MMP-13 expression.	gingerol	0-5	matrix metallopeptidase 13	Homo sapiens	123-129
33505603-17	2020	6-GIN activated autophagy by increasing the expression of autophagy-related markers (Beclin-1 and LC-3) and decreasing the expression of p62.	gingerol	0-5	beclin 1	Homo sapiens	85-93
33505603-17	2020	6-GIN activated autophagy by increasing the expression of autophagy-related markers (Beclin-1 and LC-3) and decreasing the expression of p62.	gingerol	0-5	nucleoporin 62	Homo sapiens	137-140
33505603-20	2020	The PI3K/Akt pathway was also found to be activated by 6-GIN.	gingerol	55-60	AKT serine/threonine kinase 1	Homo sapiens	9-12
33505603-21	2020	6-GIN inhibited NPMSC apoptosis and ECM degeneration, in which autophagy and the PI3K/Akt pathway were involved.	gingerol	0-5	AKT serine/threonine kinase 1	Homo sapiens	86-89
33496116-9	2020	The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6.	gingerol	84-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	120-123
33496116-9	2020	The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6.	gingerol	84-94	signal transducer and activator of transcription 3	Homo sapiens	124-129
33496116-9	2020	The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6.	gingerol	84-94	tumor necrosis factor	Homo sapiens	130-133
33496116-9	2020	The results of molecular docking showed that baicalein,berberine,licochalcone A and 6-gingerol had a high affinity with SRC,STAT3,TNF and IL6.	gingerol	84-94	interleukin 6	Homo sapiens	138-141
32737772-6	2020	Interestingly, we also found that [6]-gingerol, an anti-OA drug, could upregulate the protein level of Usp49 and suppress the Wnt/beta-catenin signaling cascade in primary rat chondrocytes.	gingerol	34-46	catenin beta 1	Rattus norvegicus	130-142
32846405-10	2020	In BV2 cells and spinal cord samples, ZOE, 6-gingerol and 6-shogaol reduced pERK levels, whereas ZOE and terpene fraction reduced HDAC1 protein levels, inhibited NF-kappaB signalling activation and decreased IL-1beta, TNF-alpha and IL-6 release.	gingerol	43-53	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	76-80
32928188-15	2020	Western blot and RT-qPCR showed that 6-gingerol inhibited the expression of proinflammatory factors (TNF-alpha, IL-6, iNOS) in CECs, and inhibition of IkappaBalpha degradation and phosphorylation of p65 involved in NF-kappaB pathway.	gingerol	37-47	tumor necrosis factor	Rattus norvegicus	101-110
33061309-17	2020	TPH, MAO-A, SERT, and 5-HT3 receptor are important in 5-HT metabolism, and cisplatin-induced alterations in the associated protein/mRNA levels were restored when treated with [6]-gingerol.	gingerol	177-187	tryptophan hydroxylase 1	Rattus norvegicus	0-3
33061309-17	2020	TPH, MAO-A, SERT, and 5-HT3 receptor are important in 5-HT metabolism, and cisplatin-induced alterations in the associated protein/mRNA levels were restored when treated with [6]-gingerol.	gingerol	177-187	monoamine oxidase A	Rattus norvegicus	5-10
33061309-17	2020	TPH, MAO-A, SERT, and 5-HT3 receptor are important in 5-HT metabolism, and cisplatin-induced alterations in the associated protein/mRNA levels were restored when treated with [6]-gingerol.	gingerol	177-187	solute carrier family 6 member 4	Rattus norvegicus	12-16
33061309-17	2020	TPH, MAO-A, SERT, and 5-HT3 receptor are important in 5-HT metabolism, and cisplatin-induced alterations in the associated protein/mRNA levels were restored when treated with [6]-gingerol.	gingerol	177-187	5-hydroxytryptamine receptor 3A	Rattus norvegicus	22-36
33061309-18	2020	Conclusion: This suggests that the antiemetic effect of [6]-gingerol against cisplatin-induced emesis may be due to 5-HT attenuation via modulating the TPH/MAO-A/SERT/5-HT/5-HT3 receptor system.	gingerol	56-68	tryptophan hydroxylase 1	Rattus norvegicus	152-155
33061309-18	2020	Conclusion: This suggests that the antiemetic effect of [6]-gingerol against cisplatin-induced emesis may be due to 5-HT attenuation via modulating the TPH/MAO-A/SERT/5-HT/5-HT3 receptor system.	gingerol	56-68	monoamine oxidase A	Rattus norvegicus	156-161
33061309-18	2020	Conclusion: This suggests that the antiemetic effect of [6]-gingerol against cisplatin-induced emesis may be due to 5-HT attenuation via modulating the TPH/MAO-A/SERT/5-HT/5-HT3 receptor system.	gingerol	56-68	5-hydroxytryptamine receptor 3A	Rattus norvegicus	172-186
32681941-0	2020	6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway.	gingerol	0-10	AKT serine/threonine kinase 1	Homo sapiens	95-98
32681941-0	2020	6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway.	gingerol	0-10	mechanistic target of rapamycin kinase	Homo sapiens	99-103
32681941-0	2020	6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway.	gingerol	0-10	signal transducer and activator of transcription 3	Homo sapiens	104-109
32681941-8	2020	In terms of mechanism, 6-Gingerol potently suppressed phosphorylation of serine-threonine protein kinase (Akt) - mammalian target of rapamycin (mTOR) - signal transducer and activator of transcription 3 (STAT3) in LPS-treated microglia.	gingerol	23-33	AKT serine/threonine kinase 1	Homo sapiens	106-109
32681941-8	2020	In terms of mechanism, 6-Gingerol potently suppressed phosphorylation of serine-threonine protein kinase (Akt) - mammalian target of rapamycin (mTOR) - signal transducer and activator of transcription 3 (STAT3) in LPS-treated microglia.	gingerol	23-33	mechanistic target of rapamycin kinase	Homo sapiens	113-142
32681941-8	2020	In terms of mechanism, 6-Gingerol potently suppressed phosphorylation of serine-threonine protein kinase (Akt) - mammalian target of rapamycin (mTOR) - signal transducer and activator of transcription 3 (STAT3) in LPS-treated microglia.	gingerol	23-33	mechanistic target of rapamycin kinase	Homo sapiens	144-148
32681941-8	2020	In terms of mechanism, 6-Gingerol potently suppressed phosphorylation of serine-threonine protein kinase (Akt) - mammalian target of rapamycin (mTOR) - signal transducer and activator of transcription 3 (STAT3) in LPS-treated microglia.	gingerol	23-33	signal transducer and activator of transcription 3	Homo sapiens	152-202
32681941-8	2020	In terms of mechanism, 6-Gingerol potently suppressed phosphorylation of serine-threonine protein kinase (Akt) - mammalian target of rapamycin (mTOR) - signal transducer and activator of transcription 3 (STAT3) in LPS-treated microglia.	gingerol	23-33	signal transducer and activator of transcription 3	Homo sapiens	204-209
32681941-9	2020	Taken together, the present study suggested that 6-Gingerol improved cerebral ischemia injury by suppressing microglia-mediated neuroinflammation by down-regulating Akt-mTOR-STAT3 pathway.	gingerol	49-59	AKT serine/threonine kinase 1	Homo sapiens	165-168
32681941-9	2020	Taken together, the present study suggested that 6-Gingerol improved cerebral ischemia injury by suppressing microglia-mediated neuroinflammation by down-regulating Akt-mTOR-STAT3 pathway.	gingerol	49-59	mechanistic target of rapamycin kinase	Homo sapiens	169-173
32681941-9	2020	Taken together, the present study suggested that 6-Gingerol improved cerebral ischemia injury by suppressing microglia-mediated neuroinflammation by down-regulating Akt-mTOR-STAT3 pathway.	gingerol	49-59	signal transducer and activator of transcription 3	Homo sapiens	174-179
33061309-0	2020	[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats.	gingerol	0-12	tryptophan hydroxylase 1	Rattus norvegicus	66-69
33061309-0	2020	[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats.	gingerol	0-12	monoamine oxidase A	Rattus norvegicus	70-75
33061309-0	2020	[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats.	gingerol	0-12	5-hydroxytryptamine receptor 3A	Rattus norvegicus	86-100
33061309-3	2020	This study is designed to investigate [6]-gingerol"s antiemetic mechanism focusing on the 5-hydroxytryptamine (serotonin, 5-HT) system by evaluating the synthesis, metabolism and reuptake of 5-HT, as well as the mechanism of 5-hydroxytryptamine type 3 receptor (5-HT3 receptor), in a cisplatin-induced pica model of rats.	gingerol	38-50	5-hydroxytryptamine receptor 3A	Rattus norvegicus	225-260
33061309-3	2020	This study is designed to investigate [6]-gingerol"s antiemetic mechanism focusing on the 5-hydroxytryptamine (serotonin, 5-HT) system by evaluating the synthesis, metabolism and reuptake of 5-HT, as well as the mechanism of 5-hydroxytryptamine type 3 receptor (5-HT3 receptor), in a cisplatin-induced pica model of rats.	gingerol	38-50	5-hydroxytryptamine receptor 3A	Rattus norvegicus	262-276
32928188-15	2020	Western blot and RT-qPCR showed that 6-gingerol inhibited the expression of proinflammatory factors (TNF-alpha, IL-6, iNOS) in CECs, and inhibition of IkappaBalpha degradation and phosphorylation of p65 involved in NF-kappaB pathway.	gingerol	37-47	interleukin 6	Rattus norvegicus	112-116
32928188-15	2020	Western blot and RT-qPCR showed that 6-gingerol inhibited the expression of proinflammatory factors (TNF-alpha, IL-6, iNOS) in CECs, and inhibition of IkappaBalpha degradation and phosphorylation of p65 involved in NF-kappaB pathway.	gingerol	37-47	nitric oxide synthase 2	Rattus norvegicus	118-122
32928188-15	2020	Western blot and RT-qPCR showed that 6-gingerol inhibited the expression of proinflammatory factors (TNF-alpha, IL-6, iNOS) in CECs, and inhibition of IkappaBalpha degradation and phosphorylation of p65 involved in NF-kappaB pathway.	gingerol	37-47	synaptotagmin 1	Rattus norvegicus	199-202
32876538-2	2022	This study demonstrated the putative inhibitory potential of curcumin, allicin, and gingerol towards cathepsin K, COVID-19 main protease, and SARS-CoV 3 C-like protease.	gingerol	84-92	cathepsin K	Homo sapiens	101-112
32483405-0	2020	Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway.	gingerol	71-81	tumor protein p53	Homo sapiens	106-109
32223496-5	2020	Upon continuous computational exploration with induced fit docking (IFD), 6-Gingerol, Yakuchinone A and Yakuchinone B were identified as the best inhibitors of COX-2, IKK, and TBK-1 respectively.	gingerol	74-84	TANK binding kinase 1	Homo sapiens	176-181
32720790-0	2021	6-Gingerol protects cardiomyocytes against hypoxia-induced injury by regulating the KCNQ1OT1/miR-340-5p/ PI3K/AKT pathway.	gingerol	0-10	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	84-92
32720790-0	2021	6-Gingerol protects cardiomyocytes against hypoxia-induced injury by regulating the KCNQ1OT1/miR-340-5p/ PI3K/AKT pathway.	gingerol	0-10	AKT serine/threonine kinase 1	Homo sapiens	110-113
32720790-9	2021	Overexpression of KCNQ1OT1 aggravated hypoxia-induced cardiomyocytes injury and reversed the protective effect of 6-Gingerol on cardiomyocytes injury.	gingerol	114-124	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	18-26
32720790-13	2021	CONCLUSIONS: 6-Gingerol could hinder the expression of KCNQ1OT1 to protect cardiomyocytes from hypoxia-induced injury through regulation of the miR-340-5p/ PI3K/AKT pathway, providing a new mechanism of 6-Gingerol protecting cardiomyocytes from injury.	gingerol	13-23	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	55-63
32720790-13	2021	CONCLUSIONS: 6-Gingerol could hinder the expression of KCNQ1OT1 to protect cardiomyocytes from hypoxia-induced injury through regulation of the miR-340-5p/ PI3K/AKT pathway, providing a new mechanism of 6-Gingerol protecting cardiomyocytes from injury.	gingerol	13-23	AKT serine/threonine kinase 1	Homo sapiens	161-164
32720790-13	2021	CONCLUSIONS: 6-Gingerol could hinder the expression of KCNQ1OT1 to protect cardiomyocytes from hypoxia-induced injury through regulation of the miR-340-5p/ PI3K/AKT pathway, providing a new mechanism of 6-Gingerol protecting cardiomyocytes from injury.	gingerol	203-213	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	55-63
32664351-0	2020	10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells.	gingerol	0-11	AKT serine/threonine kinase 1	Homo sapiens	48-51
32664351-8	2020	10-gingerol suppressed the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells.	gingerol	0-11	AKT serine/threonine kinase 1	Homo sapiens	112-115
32664351-9	2020	Moreover, 10-gingerol was found to modulate the lipid rafts of MDA-MB-231/IR cells and attenuate the key PI3K/Akt signaling components in lipid rafts.	gingerol	10-21	AKT serine/threonine kinase 1	Homo sapiens	110-113
32664351-10	2020	The cholesterol content of the lipid rafts and rafts-resident Akt signaling were also affected by exposure to 10-gingerol.	gingerol	110-121	AKT serine/threonine kinase 1	Homo sapiens	62-65
32664351-11	2020	The results of the present study highlight rafts-associated PI3K/Akt signaling as a new target of 10-gingerol in MDA-MB-231/IR cells, thus rationalizing a new rafts-mediated treatment approach for radio-resistant triple negative breast cancer cells.	gingerol	98-109	AKT serine/threonine kinase 1	Homo sapiens	65-68
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	caspase 3	Mus musculus	132-141
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	toll-like receptor 4	Mus musculus	143-147
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 14	Mus musculus	160-163
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 14	Mus musculus	167-170
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 3	Mus musculus	172-178
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 3	Mus musculus	182-188
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 8	Mus musculus	190-193
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 8	Mus musculus	201-204
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	B cell leukemia/lymphoma 2	Mus musculus	220-225
32438504-10	2020	CONCLUSION: The protective effect of [6]-gingerol in mice with ISO-induced myocardial fibrosis may be related to the inhibition of oxidative stress, inflammation, and apoptosis, potentially through the TLR4/MAPKs/NF-kappaB signaling pathway.	gingerol	37-49	toll-like receptor 4	Mus musculus	202-206
32438504-10	2020	CONCLUSION: The protective effect of [6]-gingerol in mice with ISO-induced myocardial fibrosis may be related to the inhibition of oxidative stress, inflammation, and apoptosis, potentially through the TLR4/MAPKs/NF-kappaB signaling pathway.	gingerol	37-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	213-222
32531697-11	2020	We found that the NF-kappaB/MAPK signaling pathways, formation of ECM, production of inflammatory cytokines and injury to mammary gland cells were attenuated both in vivo and in vitro when 6-gingerol was administered.	gingerol	189-199	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-27
32692218-0	2020	6-gingerol alleviates inflammatory injury in DSS-induced ulcerative colitis mice by regulating NF-kappaB signaling.	gingerol	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
32692218-3	2020	METHODS: In this study, dextran sulfate sodium (DSS)-induced colitis mice models were established to examine the effects of 6-gingerol on IL-17 and IL-10 secretion, and the activation of NF-kappaB signaling was evaluated using enzyme-linked immunosorbent assay (ELISA), Western blotting, and immunohistochemistry.	gingerol	124-134	interleukin 17A	Mus musculus	138-143
32692218-3	2020	METHODS: In this study, dextran sulfate sodium (DSS)-induced colitis mice models were established to examine the effects of 6-gingerol on IL-17 and IL-10 secretion, and the activation of NF-kappaB signaling was evaluated using enzyme-linked immunosorbent assay (ELISA), Western blotting, and immunohistochemistry.	gingerol	124-134	interleukin 10	Mus musculus	148-153
32692218-5	2020	Immunohistochemistry showed that 6-gingerol can repair the damaged glandular structure gradually caused by DSS, significantly decrease the IL-17 level, and increase IL-10 level in bowel tissue.	gingerol	33-43	interleukin 17A	Mus musculus	139-144
32692218-5	2020	Immunohistochemistry showed that 6-gingerol can repair the damaged glandular structure gradually caused by DSS, significantly decrease the IL-17 level, and increase IL-10 level in bowel tissue.	gingerol	33-43	interleukin 10	Mus musculus	165-170
32692218-6	2020	ELISA revealed that 6-gingerol could significantly decrease the IL17 level and increase IL-10 level in both serum and bowel tissue, and the differences were all statistically significant (P<0.05).	gingerol	20-30	interleukin 17A	Mus musculus	64-68
32692218-6	2020	ELISA revealed that 6-gingerol could significantly decrease the IL17 level and increase IL-10 level in both serum and bowel tissue, and the differences were all statistically significant (P<0.05).	gingerol	20-30	interleukin 10	Mus musculus	88-93
32692218-7	2020	In addition, 6-gingerol could suppress the phosphorylation level of IkappaBalpha and p65, which was up-regulated by DSS.	gingerol	13-23	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	68-80
32692218-7	2020	In addition, 6-gingerol could suppress the phosphorylation level of IkappaBalpha and p65, which was up-regulated by DSS.	gingerol	13-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	85-88
32692218-8	2020	Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus.	gingerol	165-175	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	55-58
32692218-8	2020	Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus.	gingerol	165-175	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	220-223
32692218-9	2020	CONCLUSIONS: Our study suggests that 6-gingerol may alleviate inflammatory injury in UC mice by regulating NF-kappaB signaling pathway.	gingerol	37-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
32438504-0	2020	[6]-Gingerol Ameliorates ISO-induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation and Apoptosis Through Inhibition of TLR4/MAPKs/NF-kappaB Pathway.	gingerol	0-12	toll-like receptor 4	Mus musculus	136-140
32438504-0	2020	[6]-Gingerol Ameliorates ISO-induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation and Apoptosis Through Inhibition of TLR4/MAPKs/NF-kappaB Pathway.	gingerol	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	147-156
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	tumor necrosis factor	Mus musculus	96-105
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	interleukin 6	Mus musculus	107-111
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	FBJ osteosarcoma oncogene	Mus musculus	113-118
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	jun proto-oncogene	Mus musculus	120-125
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	BCL2-associated X protein	Mus musculus	127-130
32483405-9	2020	Moreover, it was found that 6-gingerol could increase the levels of p53 mRNA in all leukemic cell lines.	gingerol	28-38	tumor protein p53	Homo sapiens	68-71
31978803-7	2020	6-Gingerol was shown to activate the Nrf2 pathway in vivo and in vitro.	gingerol	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	37-41
32395486-9	2020	Furthermore, 6-gingerol was found to inhibit the increase of mRNA levels and serum and bowel levels of IL-6 and IL-17 induced by DSS, which is similar with mesalazine.	gingerol	13-23	interleukin 6	Mus musculus	103-107
32395486-9	2020	Furthermore, 6-gingerol was found to inhibit the increase of mRNA levels and serum and bowel levels of IL-6 and IL-17 induced by DSS, which is similar with mesalazine.	gingerol	13-23	interleukin 17A	Mus musculus	112-117
32395486-11	2020	6-gingerol could also inhibit the decrease of mRNA levels and serum and bowel levels of IL-10 induced by DSS, which is also similar to mesalazine.	gingerol	0-10	interleukin 10	Mus musculus	88-93
32395486-15	2020	Furthermore, 6-gingerol could significantly (P<0.05) inhibit the up-regulation of RORgammaT mRNA and protein, and the down-regulation of FOXP3 mRNA and protein induced by DSS, which is similar to the effect of mesalazine.	gingerol	13-23	forkhead box P3	Mus musculus	137-142
31978803-0	2020	6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.	gingerol	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	NLR family, pyrin domain containing 3	Mus musculus	98-125
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	NLR family, pyrin domain containing 3	Mus musculus	127-132
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	interleukin 1 alpha	Mus musculus	135-143
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	caspase 1	Mus musculus	149-158
31978803-8	2020	Notably, Nrf2 siRNA transfection nullified the inhibitory effects of 6-gingerol on pyroptosis in vitro.	gingerol	69-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
31978803-9	2020	In summary, these findings suggested that 6-gingerol alleviated sepsis-induced liver injury by inhibiting pyroptosis through the Nrf2 pathway.	gingerol	42-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
31789021-4	2019	6G promoted adipocyte browning, as evidenced by increases in some brown/beige fat-specific genes (PGC-1alpha, Cidea, Prdm16, Cited1, SIRT1, Tmem26 and Ucp1) and protein (UCP1, CEBP/beta, PGC-1alpha and PRDM16) expression levels.	gingerol	0-2	sirtuin 1	Mus musculus	133-138
31978803-6	2020	Consistent with these findings, 6-gingerol reduced the effects of pyroptosis induced by lipopolysaccharide (LPS) and adenosine 5"-triphosphate (ATP) in RAW 264.7 cells, as evidenced by IL-1beta and caspase-1 protein levels in the supernatant and propidium iodide (PI) staining.	gingerol	32-42	interleukin 1 alpha	Mus musculus	185-193
31978803-6	2020	Consistent with these findings, 6-gingerol reduced the effects of pyroptosis induced by lipopolysaccharide (LPS) and adenosine 5"-triphosphate (ATP) in RAW 264.7 cells, as evidenced by IL-1beta and caspase-1 protein levels in the supernatant and propidium iodide (PI) staining.	gingerol	32-42	caspase 1	Mus musculus	198-207
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	5-hydroxytryptamine receptor 3A	Rattus norvegicus	237-251
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	tryptophan hydroxylase 1	Rattus norvegicus	253-256
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	tachykinin receptor 1	Rattus norvegicus	262-274
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	tachykinin, precursor 1	Rattus norvegicus	276-279
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	solute carrier family 6 member 4	Rattus norvegicus	378-382
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	membrane metallo-endopeptidase	Rattus norvegicus	384-387
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	114-122	solute carrier family 6 member 3	Rattus norvegicus	389-392
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	5-hydroxytryptamine receptor 3A	Rattus norvegicus	237-251
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	tryptophan hydroxylase 1	Rattus norvegicus	253-256
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	tachykinin receptor 1	Rattus norvegicus	262-274
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	tachykinin, precursor 1	Rattus norvegicus	276-279
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	solute carrier family 6 member 4	Rattus norvegicus	378-382
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	membrane metallo-endopeptidase	Rattus norvegicus	384-387
31768887-7	2020	The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0-24-h and 24-72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks.	gingerol	189-197	solute carrier family 6 member 3	Rattus norvegicus	389-392
31832810-0	2020	6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3beta-cyclin D1 pathway in renal-cell carcinoma.	gingerol	0-10	AKT serine/threonine kinase 1	Homo sapiens	54-57
31832810-0	2020	6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3beta-cyclin D1 pathway in renal-cell carcinoma.	gingerol	0-10	glycogen synthase kinase 3 beta	Homo sapiens	58-67
31832810-0	2020	6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3beta-cyclin D1 pathway in renal-cell carcinoma.	gingerol	0-10	cyclin D1	Homo sapiens	68-77
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	AKT serine/threonine kinase 1	Homo sapiens	93-96
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	cyclin dependent kinase 4	Homo sapiens	133-137
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	cyclin D1	Homo sapiens	144-153
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	glycogen synthase kinase 3 beta	Homo sapiens	206-215
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	44-54	AKT serine/threonine kinase 1	Homo sapiens	123-126
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	44-54	glycogen synthase kinase 3 beta	Homo sapiens	127-136
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	44-54	cyclin D1	Homo sapiens	137-146
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	203-213	AKT serine/threonine kinase 1	Homo sapiens	123-126
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	203-213	cyclin D1	Homo sapiens	137-146
31539844-0	2020	6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis.	gingerol	0-10	mitogen-activated protein kinase 1	Mus musculus	67-71
31539844-9	2020	In addition, we assessed the role of MAPK signaling in 6-gingerol-induced effects in BMDMs and RAW264.7 cells.	gingerol	55-65	mitogen-activated protein kinase 1	Mus musculus	37-41
31539844-10	2020	RESULTS: In CLP mice, 6-gingerol significantly ameliorated sepsis development, which was associated with the reduction of serum IL-1beta.	gingerol	22-32	interleukin 1 beta	Mus musculus	128-136
31539844-11	2020	In BMDMs and RAW264.7 cells, 6-gingerol strongly attenuated pyroptosis as well as the release of caspase-1p20, HMGB1, mature IL-1beta, IL-18 in response to ATP and LPS treatment.	gingerol	29-39	high mobility group box 1	Mus musculus	111-116
31539844-11	2020	In BMDMs and RAW264.7 cells, 6-gingerol strongly attenuated pyroptosis as well as the release of caspase-1p20, HMGB1, mature IL-1beta, IL-18 in response to ATP and LPS treatment.	gingerol	29-39	interleukin 1 beta	Mus musculus	125-133
31539844-11	2020	In BMDMs and RAW264.7 cells, 6-gingerol strongly attenuated pyroptosis as well as the release of caspase-1p20, HMGB1, mature IL-1beta, IL-18 in response to ATP and LPS treatment.	gingerol	29-39	interleukin 18	Mus musculus	135-140
31539844-12	2020	6-Gingerol conferred these effects by blocking MAPK activation.	gingerol	0-10	mitogen-activated protein kinase 1	Mus musculus	47-51
31539844-13	2020	Exposure to an ERK agonist (EGF) reversed effects of 6-gingerol, causing pyroptosis, LDH and caspase-1p20 release.	gingerol	53-63	mitogen-activated protein kinase 1	Mus musculus	15-18
31539844-14	2020	CONCLUSIONS: By targeting MAPK signaling, 6-gingerol significantly suppressed secretion of pro-inflammatory cytokines and inhibited macrophage cells pyroptosis resulting in overall inhibition of sepsis development.	gingerol	42-52	mitogen-activated protein kinase 1	Mus musculus	26-30
31474506-0	2020	Corrigendum to "(6)-Gingerol induced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression" [Free Radic.	gingerol	16-28	microRNA 27b	Homo sapiens	123-130
31789021-5	2019	Moreover, 6G greatly improved mitochondrial respiration and energy metabolism by upregulating the expression levels of some mitochondrial biogenesis markers (Tfam, Nrf1, SIRT1 and p-AMPK/AMPK) and increasing the uncoupled oxygen consumption rate (OCR) of protons leaked in 3T3-L1 cells.	gingerol	10-12	transcription factor A, mitochondrial	Mus musculus	158-162
31789021-5	2019	Moreover, 6G greatly improved mitochondrial respiration and energy metabolism by upregulating the expression levels of some mitochondrial biogenesis markers (Tfam, Nrf1, SIRT1 and p-AMPK/AMPK) and increasing the uncoupled oxygen consumption rate (OCR) of protons leaked in 3T3-L1 cells.	gingerol	10-12	nuclear respiratory factor 1	Mus musculus	164-168
31789021-5	2019	Moreover, 6G greatly improved mitochondrial respiration and energy metabolism by upregulating the expression levels of some mitochondrial biogenesis markers (Tfam, Nrf1, SIRT1 and p-AMPK/AMPK) and increasing the uncoupled oxygen consumption rate (OCR) of protons leaked in 3T3-L1 cells.	gingerol	10-12	sirtuin 1	Mus musculus	170-175
31223035-0	2019	6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression.	gingerol	0-10	BCL2 interacting protein 3	Rattus norvegicus	83-88
31022566-11	2019	Capsaicin, 6-gingerol and 6-shogaol had good broad antibacterial activity with MIC values ranging from 8 to 256 mg/L against effluxing MRSA strains SA1199B (NorA), XU212 (TetK) and RN4220 (MsrA).	gingerol	11-21	methionine sulfoxide reductase A	Homo sapiens	189-193
31022566-13	2019	The effect of 6-gingerol, 6-shogaol and nonivamide on the plasmids were very active on PKM 101 (6.24-22.16%), PUB 307 (1.22-45.63%) and TP114 (0.1-7.19%) comparative to the positive control plumbagin (5.70-31.76%).	gingerol	14-24	pyruvate kinase M1/2	Homo sapiens	87-90
31043087-0	2019	6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3.	gingerol	0-11	BCL2 interacting protein 3	Rattus norvegicus	107-112
30826930-9	2019	Gingerol significantly (P &lt; 0.001) down-regulated the blood glucose level, creatinine and BUN level in a dose-dependent manner with further significantly (P &lt; 0.001) alteration in pro-inflammatory cytokines, nuclear factor kappa B (N-kappaB) activation, renal p38MAPK, and TGF-beta.	gingerol	0-8	transforming growth factor, beta 1	Rattus norvegicus	279-287
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	myeloperoxidase	Mus musculus	75-78
31576251-9	2019	Thus, 6-shogaol, and other gingerols and shogaols inhibit cPLA2 activity and reduce LPS-induced PGE2 production via a different mechanism from traditional anti-inflammatory drugs.	gingerol	27-36	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	58-63
31857975-6	2019	Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol.	gingerol	97-108	cyclin A2	Homo sapiens	43-51
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	tumor necrosis factor	Mus musculus	109-118
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	interleukin 1 beta	Mus musculus	120-128
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	prostaglandin-endoperoxide synthase 2	Mus musculus	130-135
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	nitric oxide synthase 2, inducible	Mus musculus	140-144
30811726-0	2019	[6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway.	gingerol	0-12	AKT serine/threonine kinase 1	Homo sapiens	130-133
31316575-0	2019	Corrigendum to "6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats".	gingerol	16-26	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
30811726-10	2019	Our study demonstrates that [6]-gingerol enhances the cisplatin sensitivity of gastric cancer cells and that the mechanisms involve G1 phase arrest, migration and invasion suppression via PI3K/AKT signaling pathway.	gingerol	28-40	AKT serine/threonine kinase 1	Homo sapiens	193-196
30963995-0	2019	Retraction: 6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro.	gingerol	12-22	signal transducer and activator of transcription 3	Homo sapiens	72-77
30942163-0	2019	6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro.	gingerol	0-10	signal transducer and activator of transcription 3	Homo sapiens	60-65
30886640-0	2019	6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK1/2-NF-kappaB Pathway.	gingerol	0-10	high mobility group box 2	Homo sapiens	103-108
30575271-0	2019	6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1alpha Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.	gingerol	0-10	PPARG coactivator 1 alpha	Rattus norvegicus	162-172
30575271-0	2019	6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1alpha Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.	gingerol	0-10	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	202-213
30575271-0	2019	6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1alpha Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.	gingerol	0-10	adiponectin receptor 1	Rattus norvegicus	227-234
30575271-1	2019	SCOPE: This study investigates the dual actions of 6-gingerol in stimulating both plasma adiponectin and muscular adiponectin receptor signaling in naturally ageing rats.	gingerol	51-61	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	89-100
30575271-1	2019	SCOPE: This study investigates the dual actions of 6-gingerol in stimulating both plasma adiponectin and muscular adiponectin receptor signaling in naturally ageing rats.	gingerol	51-61	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	114-125
30575271-3	2019	6-Gingerol can attenuate age-associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA-IR index and inhibit the decrease of muscular p-Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	220-223
30575271-3	2019	6-Gingerol can attenuate age-associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA-IR index and inhibit the decrease of muscular p-Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	224-227
30575271-5	2019	More importantly, 6-gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC-1alpha in vivo and in vitro.	gingerol	18-28	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	78-89
30575271-5	2019	More importantly, 6-gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC-1alpha in vivo and in vitro.	gingerol	18-28	adiponectin receptor 1	Rattus norvegicus	133-140
30575271-5	2019	More importantly, 6-gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC-1alpha in vivo and in vitro.	gingerol	18-28	PPARG coactivator 1 alpha	Rattus norvegicus	221-231
30886640-0	2019	6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK1/2-NF-kappaB Pathway.	gingerol	0-10	mitogen-activated protein kinase 8	Homo sapiens	109-113
30886640-0	2019	6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK1/2-NF-kappaB Pathway.	gingerol	0-10	nuclear factor kappa B subunit 1	Homo sapiens	116-125
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	high mobility group box 2	Homo sapiens	53-58
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	mitogen-activated protein kinase 8	Homo sapiens	87-90
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	122-150
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	poly(ADP-ribose) polymerase 1	Homo sapiens	152-156
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	caspase 3	Homo sapiens	162-171
30886640-8	2019	HMGB2 treatment mimicked the effect of I/R-induced cell damage, which was reversed by 6-gingerol administration.	gingerol	86-96	high mobility group box 2	Homo sapiens	0-5
30886640-9	2019	On the other hand, transcriptional activity of NF-kappaB was reduced in 6-gingerol treated cells.	gingerol	72-82	nuclear factor kappa B subunit 1	Homo sapiens	47-56
30886640-10	2019	Thus, overall results indicated that 6-gingerol administration protected I/R-induced cardiomyocytes apoptosis via JNK/NF-kappaB pathway in the regulation of HMGB2.	gingerol	37-47	mitogen-activated protein kinase 8	Homo sapiens	114-117
30886640-10	2019	Thus, overall results indicated that 6-gingerol administration protected I/R-induced cardiomyocytes apoptosis via JNK/NF-kappaB pathway in the regulation of HMGB2.	gingerol	37-47	nuclear factor kappa B subunit 1	Homo sapiens	118-127
30886640-10	2019	Thus, overall results indicated that 6-gingerol administration protected I/R-induced cardiomyocytes apoptosis via JNK/NF-kappaB pathway in the regulation of HMGB2.	gingerol	37-47	high mobility group box 2	Homo sapiens	157-162
30251306-8	2018	These data suggest that the antiallodynic effect induced by [6]-gingerol is mediated by the serotoninergic system involving the activation of 5-HT1A/1B/1D/5A receptors, as well as the NO-cyclic guanosine monophosphate-ATP-sensitive K+ channel pathway but not by the opioidergic system.	gingerol	60-72	5-hydroxytryptamine receptor 1A	Rattus norvegicus	142-148
30408433-6	2019	Mechanistically, 6-gingerol affected lipid metabolism by increasing beta-oxidation and decreasing lipogenesis through activation of PPARalpha and CPT1alpha and inhibition of DGAT-2.	gingerol	17-27	peroxisome proliferator activated receptor alpha	Rattus norvegicus	132-141
30408433-6	2019	Mechanistically, 6-gingerol affected lipid metabolism by increasing beta-oxidation and decreasing lipogenesis through activation of PPARalpha and CPT1alpha and inhibition of DGAT-2.	gingerol	17-27	carnitine palmitoyltransferase 1A	Rattus norvegicus	146-155
30408433-6	2019	Mechanistically, 6-gingerol affected lipid metabolism by increasing beta-oxidation and decreasing lipogenesis through activation of PPARalpha and CPT1alpha and inhibition of DGAT-2.	gingerol	17-27	diacylglycerol O-acyltransferase 2	Rattus norvegicus	174-180
30408433-7	2019	Furthermore, 6-gingerol reversed the decreases in citrate, Cs and ATP, lessened the damage caused by ROS, and upregulated mitochondrial marker enzymes NOX, SDH, and SIRT3 in the ageing liver, indicating its ability to strengthen mitochondrial function.	gingerol	13-23	sirtuin 3	Rattus norvegicus	165-170
30408433-8	2019	Our results showed 6-gingerol exerted a positive effect on insulin sensitivity by regulating Akt.	gingerol	19-29	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
30643517-0	2018	6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARdelta in HUVECs, HEK293, and Differentiated 3T3-L1 Cells.	gingerol	0-10	peroxisome proliferator activated receptor delta	Homo sapiens	79-88
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	nitric oxide synthase 3, endothelial cell	Mus musculus	50-83
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	nitric oxide synthase 3, endothelial cell	Mus musculus	85-89
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	vascular cell adhesion molecule 1	Mus musculus	121-153
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	vascular cell adhesion molecule 1	Mus musculus	155-160
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	tumor necrosis factor	Mus musculus	166-193
30643517-8	2018	6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFalpha) in HUVECs.	gingerol	0-11	tumor necrosis factor	Mus musculus	195-203
30643517-12	2018	6-Gingerol ameliorated the expression of biomarkers involved in the development of hypertension through PPARdelta in HUVECs, HEK293, and differentiated 3T3-L1 cells.	gingerol	0-10	peroxisome proliferator activated receptor delta	Homo sapiens	104-113
30806289-0	2019	Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats.	gingerol	32-42	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	82-87
30806289-0	2019	Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats.	gingerol	32-42	nuclear factor of activated T-cells 1	Rattus norvegicus	93-98
30806289-5	2019	6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-?.	gingerol	0-10	interleukin 4	Rattus norvegicus	72-76
30806289-5	2019	6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-?.	gingerol	0-10	interleukin 5	Rattus norvegicus	78-82
30806289-5	2019	6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-?.	gingerol	0-10	interleukin 13	Rattus norvegicus	88-93
30806289-6	2019	Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline.	gingerol	200-210	taste receptor, type 2, member 110	Rattus norvegicus	31-36
30806289-6	2019	Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline.	gingerol	200-210	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	74-79
30806289-6	2019	Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline.	gingerol	200-210	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	84-89
30595604-0	2018	Retracted: Anticancer Effects of Gingerol in Retinoblastoma Cancer Cells (RB355 Cell Line) Are Mediated via Apoptosis Induction, Cell Cycle Arrest and Upregulation of PI3K/Akt Signaling Pathway.	gingerol	33-41	AKT serine/threonine kinase 1	Homo sapiens	172-175
30864424-2	2018	Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the chlorpyrifos-induced toxicity in rats.	gingerol	47-57	growth hormone releasing hormone	Rattus norvegicus	106-109
30257370-9	2018	Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF-alpha in the rat brain.	gingerol	9-19	glial fibrillary acidic protein	Rattus norvegicus	65-69
30519268-0	2018	6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
29534560-5	2018	Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3).	gingerol	68-78	Heat shock protein 110	Caenorhabditis elegans	164-182
29534560-5	2018	Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3).	gingerol	68-78	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	184-192
29534560-5	2018	Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3).	gingerol	68-78	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	220-225
30257370-9	2018	Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF-alpha in the rat brain.	gingerol	9-19	tumor necrosis factor	Rattus norvegicus	74-83
30187878-0	2018	[10-gingerol inhibits proliferation of hepatocellular carcinoma HepG2 cells via Src/STAT3 signaling pathway].	gingerol	1-12	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	80-83
29605868-0	2018	6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress.	gingerol	0-10	apolipoprotein E	Mus musculus	73-77
30091159-3	2018	Furthermore, [6]-gingerol was assessed for its antiapoptotic effects in human gastric adenocarcinoma (AGS) cells evidenced by acridine orange/ethidium bromide staining technique and Annexin-V assay.	gingerol	13-25	annexin A5	Homo sapiens	182-191
30187878-0	2018	[10-gingerol inhibits proliferation of hepatocellular carcinoma HepG2 cells via Src/STAT3 signaling pathway].	gingerol	1-12	signal transducer and activator of transcription 3	Homo sapiens	84-89
30187878-2	2018	METHODS: SYBYL-X2.1 software was used to simulate the interaction between 10-gingerol and Src.	gingerol	74-85	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-93
30187878-5	2018	RESULTS: 10-gingerol was capable of forming hydrogen bond with such Src residues as TRY-340, MET-341, MET-314, ASP-404, and ILE-336.	gingerol	9-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
30187878-8	2018	Western blotting showed that 10-gingerol at 3 and 10 mumol/L significantly decreased the phosphorylation levels of Src and STAT3 in HepG2 cells (P &lt; 0.01).	gingerol	29-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
30187878-8	2018	Western blotting showed that 10-gingerol at 3 and 10 mumol/L significantly decreased the phosphorylation levels of Src and STAT3 in HepG2 cells (P &lt; 0.01).	gingerol	29-40	signal transducer and activator of transcription 3	Homo sapiens	123-128
30187878-9	2018	10-gingerol at 1, 3, and 10 mumol/L significantly decreased the mRNA expressions of cyclin D1 and CMCC as shown by qPCR (P &lt; 0.01).	gingerol	0-11	cyclin D1	Homo sapiens	84-93
30187878-10	2018	CONCLUSIONS: 10-gingerol can dose-dependently inhibit the proliferation of HepG2 cells and suppress the activation of Src and STAT3.	gingerol	13-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	118-121
30187878-10	2018	CONCLUSIONS: 10-gingerol can dose-dependently inhibit the proliferation of HepG2 cells and suppress the activation of Src and STAT3.	gingerol	13-24	signal transducer and activator of transcription 3	Homo sapiens	126-131
29615601-0	2018	Anticancer Effects of Gingerol in Retinoblastoma Cancer Cells (RB355 Cell Line) Are Mediated via Apoptosis Induction, Cell Cycle Arrest and Upregulation of PI3K/Akt Signaling Pathway.	gingerol	22-30	AKT serine/threonine kinase 1	Homo sapiens	161-164
29508185-0	2018	Anti-Inflammatory Effects of Gingerol on Lipopolysaccharide-Stimulated RAW 264.7 Cells by Inhibiting NF-kappaB Signaling Pathway.	gingerol	29-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
29508185-11	2018	In addition, gingerol also observably inhibited LPS-induced TNF-alpha, IL-1beta, IL-6, and PGE2 (p &lt; 0.01) expression and secretion in a dose-dependent manner.	gingerol	13-21	tumor necrosis factor	Mus musculus	60-69
29508185-11	2018	In addition, gingerol also observably inhibited LPS-induced TNF-alpha, IL-1beta, IL-6, and PGE2 (p &lt; 0.01) expression and secretion in a dose-dependent manner.	gingerol	13-21	interleukin 1 beta	Mus musculus	71-79
29508185-11	2018	In addition, gingerol also observably inhibited LPS-induced TNF-alpha, IL-1beta, IL-6, and PGE2 (p &lt; 0.01) expression and secretion in a dose-dependent manner.	gingerol	13-21	interleukin 6	Mus musculus	81-85
29508185-12	2018	At the genetic level, after the intervention of gingerol, mRNA transcriptions of iNOS, COX-2, IL-6, and IL-1beta were all decreased.	gingerol	48-56	nitric oxide synthase 2, inducible	Mus musculus	81-85
29508185-12	2018	At the genetic level, after the intervention of gingerol, mRNA transcriptions of iNOS, COX-2, IL-6, and IL-1beta were all decreased.	gingerol	48-56	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
29508185-12	2018	At the genetic level, after the intervention of gingerol, mRNA transcriptions of iNOS, COX-2, IL-6, and IL-1beta were all decreased.	gingerol	48-56	interleukin 6	Mus musculus	94-98
29508185-12	2018	At the genetic level, after the intervention of gingerol, mRNA transcriptions of iNOS, COX-2, IL-6, and IL-1beta were all decreased.	gingerol	48-56	interleukin 1 beta	Mus musculus	104-112
29508185-13	2018	The protein expressions of iNOS, NF-kappaB, p-p65, and p-IkappaB were significantly increased in LPS-induced cells, while these changes were reversed by the treatment with gingerol.	gingerol	172-180	nitric oxide synthase 2, inducible	Mus musculus	27-31
29508185-13	2018	The protein expressions of iNOS, NF-kappaB, p-p65, and p-IkappaB were significantly increased in LPS-induced cells, while these changes were reversed by the treatment with gingerol.	gingerol	172-180	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
29508185-14	2018	This study suggested that gingerol exerts its anti-inflammatory activities in LPS-induced macrophages which can inhibit the production of inflammatory cytokines by targeting the NF-kappaB signaling pathway.	gingerol	26-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
29356228-7	2018	Also, an investigation using 6-shogaol and 6-gingerol supported the concept that the alpha, beta-unsaturated carbonyl structure plays an important role in the interaction with Keap1.	gingerol	43-53	kelch like ECH associated protein 1	Homo sapiens	176-181
29957939-2	2018	Orosensory intervention with 6-gingerol induced a significant increase in the abundance of salivary sulfhydryl oxidase 1, which was found to catalyze the oxidative decline of odor-active 2-furfurylthiol, thus resulting in a decrease in the odorant levels in exhaled breath, as shown by PTR-MS, and a reduction of the perceived sulfury after-smell.	gingerol	29-39	quiescin sulfhydryl oxidase 1	Homo sapiens	100-120
29615601-12	2018	CONCLUSIONS Gingerol exhibits potent anticancer effects in RB355 human retinoblastoma cancer cells and these effects were mediated via apoptosis induction, cell cycle arrest, and modulation of the PI3K/Akt signaling pathway.	gingerol	12-20	AKT serine/threonine kinase 1	Homo sapiens	202-205
29535632-0	2018	6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells.	gingerol	0-10	low density lipoprotein receptor	Homo sapiens	72-76
29743926-0	2018	6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
29743926-7	2018	Moreover, pretreatment with 6-G significantly inhibited myocardial apoptosis and caspase-3 activation induced by I/R.	gingerol	28-31	caspase 3	Rattus norvegicus	81-90
29743926-9	2018	Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart.	gingerol	44-47	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
29535632-4	2018	HepG2 cells were incubated with various concentrations of 6-GN ranging from 50 to 200 muM for 24 h. Results showed that both cellular total cholesterol and free cholesterol decreased in a dose-dependent manner.	gingerol	58-62	latexin	Homo sapiens	86-89
29535632-5	2018	Besides, 6-GN ranging from 100 to 200 muM increased the LDLR protein and uptake of fluorescent-labeled LDL.	gingerol	9-13	latexin	Homo sapiens	38-41
29535632-5	2018	Besides, 6-GN ranging from 100 to 200 muM increased the LDLR protein and uptake of fluorescent-labeled LDL.	gingerol	9-13	low density lipoprotein receptor	Homo sapiens	56-60
29535632-7	2018	It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRalpha and ABCA1.	gingerol	18-22	low density lipoprotein receptor	Homo sapiens	77-81
29535632-7	2018	It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRalpha and ABCA1.	gingerol	18-22	sterol regulatory element binding transcription factor 2	Homo sapiens	104-110
29535632-7	2018	It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRalpha and ABCA1.	gingerol	18-22	nuclear receptor subfamily 1 group H member 3	Homo sapiens	172-180
29535632-7	2018	It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRalpha and ABCA1.	gingerol	18-22	ATP binding cassette subfamily A member 1	Homo sapiens	185-190
29267793-0	2017	6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.	gingerol	0-10	matrix metallopeptidase 2	Mus musculus	48-52
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	brain derived neurotrophic factor	Mus musculus	61-65
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	thymoma viral proto-oncogene 1	Mus musculus	125-128
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	cAMP responsive element binding protein 1	Mus musculus	134-171
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	cAMP responsive element binding protein 1	Mus musculus	173-177
30175793-0	2018	[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa.	gingerol	3-12	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-102
30175793-0	2018	[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa.	gingerol	3-12	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
30175793-2	2018	Recently, our group observed that the serosal administration of [6]-gingerol stimulated electrogenic sodium absorption in the rat colon via the capsaicin receptor, TRPV1.	gingerol	64-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-162
30175793-2	2018	Recently, our group observed that the serosal administration of [6]-gingerol stimulated electrogenic sodium absorption in the rat colon via the capsaicin receptor, TRPV1.	gingerol	64-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	164-169
30175793-4	2018	In the present study, we assessed whether [6]-gingerol stimulated sodium absorption via TRPV1 in the colonic mucosal epithelium.	gingerol	46-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
30175793-5	2018	We compared the effect of [6]-gingerol on TRPV1-dependent colonic sodium absorption in the colon preparation with or without muscle layer.	gingerol	26-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
30175793-9	2018	DeltaPD induction by [6]-gingerol was considerably diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1, but not by AP-18, an inhibitor of TRPA1.	gingerol	21-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-116
30175793-9	2018	DeltaPD induction by [6]-gingerol was considerably diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1, but not by AP-18, an inhibitor of TRPA1.	gingerol	21-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-122
30175793-10	2018	These results suggest that [6]-gingerol induces amiloride-sensitive electrogenic sodium absorption in the rat colon via TRPV1 expressed in the colonic mucosal epithelium, and that this effect is independent of TRPV1 in the colonic muscle layer.	gingerol	27-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
28051355-9	2018	The Caco-2 cell monolayer model and Rhodamine-123 uptake assay indicated that both liquiritin and 6-gingerol could increase the absorption of aconitine by inhibiting the activity of P-gp.	gingerol	98-108	phosphoglycolate phosphatase	Homo sapiens	182-186
28051355-11	2018	These results indicated that both liquiritin and 6-gingerol could promote the absorption of aconitine and increase its drug concentration in blood by inhibiting the activity of P-gp, and it could also provide evidence for compatibility mechanism of the traditional Chinese herbal formula, Sini Decoction.	gingerol	49-59	phosphoglycolate phosphatase	Homo sapiens	177-181
29267793-7	2017	Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9.	gingerol	10-20	matrix metallopeptidase 9	Mus musculus	183-187
29267793-9	2017	We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-beta concentration.	gingerol	92-102	fibroblast growth factor 7	Mus musculus	118-121
29267793-9	2017	We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-beta concentration.	gingerol	92-102	vascular endothelial growth factor A	Mus musculus	123-127
29267793-9	2017	We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-beta concentration.	gingerol	92-102	insulin-like growth factor 1	Mus musculus	133-138
29267793-9	2017	We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-beta concentration.	gingerol	92-102	transforming growth factor, beta 1	Mus musculus	169-177
29267793-10	2017	Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.	gingerol	29-39	matrix metallopeptidase 2	Mus musculus	101-105
29267793-10	2017	Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.	gingerol	29-39	matrix metallopeptidase 9	Mus musculus	110-114
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	gingerol	106-118	phosphoglycolate phosphatase	Mus musculus	59-63
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	gingerol	106-118	phosphoglycolate phosphatase	Mus musculus	194-198
28249781-5	2017	6-Gingerol activated AMPK, but inhibited PI3K/AKT phosphorylation with reduced P70S6K expression and also suppressed the mTOR phosphorylation.	gingerol	0-10	AKT serine/threonine kinase 1	Homo sapiens	46-49
28249781-5	2017	6-Gingerol activated AMPK, but inhibited PI3K/AKT phosphorylation with reduced P70S6K expression and also suppressed the mTOR phosphorylation.	gingerol	0-10	ribosomal protein S6 kinase B1	Homo sapiens	79-85
28249781-5	2017	6-Gingerol activated AMPK, but inhibited PI3K/AKT phosphorylation with reduced P70S6K expression and also suppressed the mTOR phosphorylation.	gingerol	0-10	mechanistic target of rapamycin kinase	Homo sapiens	121-125
29267793-0	2017	6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.	gingerol	0-10	matrix metallopeptidase 9	Mus musculus	57-61
29267793-7	2017	Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9.	gingerol	10-20	matrix metallopeptidase 2	Mus musculus	174-178
28872603-6	2017	6-gingerol, 10-gingerol, 6-shogaol, and 10-shogaol at the concentration of 100 muM significantly inhibited the proliferation in PC3R but 6-gingerol, 6-shogaol, and 10-shogaol displayed similar activity in PC3.	gingerol	0-10	proprotein convertase subtilisin/kexin type 1	Homo sapiens	128-131
28872603-6	2017	6-gingerol, 10-gingerol, 6-shogaol, and 10-shogaol at the concentration of 100 muM significantly inhibited the proliferation in PC3R but 6-gingerol, 6-shogaol, and 10-shogaol displayed similar activity in PC3.	gingerol	12-23	proprotein convertase subtilisin/kexin type 1	Homo sapiens	128-131
28254022-3	2017	We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2-related-factor-2 (Nrf2)-dependent pathway.	gingerol	46-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-219
28709132-0	2017	Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells.	gingerol	22-32	AKT serine/threonine kinase 1	Homo sapiens	116-119
28709132-10	2017	However, the protective effects of 6-Gin were abolished by co-treatment with LY294002, AKT inhibitor IV or L-NAME at the HG state.	gingerol	35-40	AKT serine/threonine kinase 1	Homo sapiens	87-90
28709132-11	2017	Collectively, 6-Gin attenuated the injury of HUVECs induced by HG through the activation of PI3K-AKT-eNOS signal pathway.	gingerol	14-19	AKT serine/threonine kinase 1	Homo sapiens	97-100
28793909-0	2017	[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic beta-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.	gingerol	4-12	glucagon	Mus musculus	52-57
28793909-0	2017	[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic beta-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.	gingerol	4-12	RAB10, member RAS oncogene family	Mus musculus	156-161
28793909-0	2017	[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic beta-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.	gingerol	4-12	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	197-202
28793909-11	2017	Pharmacological intervention of GLP-1 levels regulated the effect of [6]-Gingerol on insulin secretion.	gingerol	69-81	glucagon	Mus musculus	32-37
28793909-12	2017	Mechanistically, [6]-Gingerol treatment upregulated and activated cAMP, PKA, and CREB in the pancreatic islets, which are critical components of GLP-1-mediated insulin secretion pathway.	gingerol	21-29	cAMP responsive element binding protein 1	Mus musculus	81-85
28793909-12	2017	Mechanistically, [6]-Gingerol treatment upregulated and activated cAMP, PKA, and CREB in the pancreatic islets, which are critical components of GLP-1-mediated insulin secretion pathway.	gingerol	21-29	glucagon	Mus musculus	145-150
28793909-13	2017	[6]-Gingerol upregulated both Rab27a GTPase and its effector protein Slp4-a expression in isolated islets, which regulates the exocytosis of insulin-containing dense-core granules.	gingerol	4-12	synaptotagmin-like 4	Mus musculus	69-73
28793909-16	2017	CONCLUSIONS: Collectively, our study reports that GLP-1 mediates the insulinotropic activity of [6]-Gingerol, and [6]-Gingerol treatment facilitates glucose disposal in skeletal muscles through increased activity of glycogen synthase 1 and enhanced cell surface presentation of GLUT4 transporters.	gingerol	96-108	glucagon	Mus musculus	50-55
28793909-16	2017	CONCLUSIONS: Collectively, our study reports that GLP-1 mediates the insulinotropic activity of [6]-Gingerol, and [6]-Gingerol treatment facilitates glucose disposal in skeletal muscles through increased activity of glycogen synthase 1 and enhanced cell surface presentation of GLUT4 transporters.	gingerol	100-108	glucagon	Mus musculus	50-55
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	gingerol	54-62	myostatin	Mus musculus	67-76
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	gingerol	54-62	myostatin	Mus musculus	78-82
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	gingerol	205-213	activin receptor IIB	Mus musculus	146-171
29069785-5	2017	In addition, [10]-gingerol is well tolerated in vivo, induces a marked increase in caspase-3 activation and inhibits orthotopic tumour growth in a syngeneic mouse model of spontaneous breast cancer metastasis.	gingerol	18-26	caspase 3	Mus musculus	83-92
28254022-6	2017	Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue.	gingerol	14-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
28254022-6	2017	Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue.	gingerol	14-26	glyoxalase 1	Mus musculus	142-154
28588301-0	2017	Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer"s disease: emphasis on inhibition of beta-amyloid, COX-2, alpha-, beta - secretases and APH1a.	gingerol	22-30	aph1 homolog A, gamma secretase subunit	Mus musculus	164-169
28588301-4	2017	The curative effects of gingerol were assessed through measurement of beta-amyloid (Abeta-42), alpha-, beta- secretases, APH1a and COX-2 levels.	gingerol	24-32	aph1 homolog A, gamma secretase subunit	Mus musculus	121-126
28167239-0	2017	6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-kappaB signalling.	gingerol	0-10	mitogen activated protein kinase 14	Rattus norvegicus	98-101
28349496-2	2017	Preclinical studies demonstrated that 6-gingerol has an anti-emetic activity by inhibiting neurokinin-1, serotonin, and dopamine receptors.	gingerol	38-48	tachykinin precursor 1	Homo sapiens	91-103
28315687-5	2017	The inhibitory effect of [10]-gingerol on the growth of MDA-MB-231 cells was associated with a reduction in the number of rounds of cell division and evidence of S phase-cell cycle arrest, as well as induction of apoptosis due to mitochondrial outer membrane permeabilization and the release of proapoptotic mitochondrial cytochrome c and SMAC/DIABLO into the cytoplasm.	gingerol	25-38	cytochrome c, somatic	Homo sapiens	322-334
28315687-5	2017	The inhibitory effect of [10]-gingerol on the growth of MDA-MB-231 cells was associated with a reduction in the number of rounds of cell division and evidence of S phase-cell cycle arrest, as well as induction of apoptosis due to mitochondrial outer membrane permeabilization and the release of proapoptotic mitochondrial cytochrome c and SMAC/DIABLO into the cytoplasm.	gingerol	25-38	diablo IAP-binding mitochondrial protein	Homo sapiens	339-343
28315687-5	2017	The inhibitory effect of [10]-gingerol on the growth of MDA-MB-231 cells was associated with a reduction in the number of rounds of cell division and evidence of S phase-cell cycle arrest, as well as induction of apoptosis due to mitochondrial outer membrane permeabilization and the release of proapoptotic mitochondrial cytochrome c and SMAC/DIABLO into the cytoplasm.	gingerol	25-38	diablo IAP-binding mitochondrial protein	Homo sapiens	344-350
28113081-0	2017	Effect of 6-gingerol on AMPK- NF-kappaB axis in high fat diet fed rats.	gingerol	10-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	24-28
28113081-2	2017	We examined the effect of 6-gingerol, an active ingredient of ginger on AMPK-NF-kappaB pathway in high fat diet (HFD) rats in comparison to fish oil.	gingerol	26-36	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	72-76
28113081-4	2017	RESULTS: 6-Gingerol substantially enhanced phosphorylated AMPK-alpha1 more than fish oil and reduced the P65 via upregulation of Sirt-6 and downregulation of resistin, and resulted in attenuation of the inflammatory molecules P65, FFAs and TNF-alpha more than fish oil treated groups but in an insignificant statistical manner, those effects were accompanied by a substantial hypoglycemic effect.	gingerol	9-19	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	58-69
28113081-4	2017	RESULTS: 6-Gingerol substantially enhanced phosphorylated AMPK-alpha1 more than fish oil and reduced the P65 via upregulation of Sirt-6 and downregulation of resistin, and resulted in attenuation of the inflammatory molecules P65, FFAs and TNF-alpha more than fish oil treated groups but in an insignificant statistical manner, those effects were accompanied by a substantial hypoglycemic effect.	gingerol	9-19	sirtuin 6	Rattus norvegicus	129-135
28113081-4	2017	RESULTS: 6-Gingerol substantially enhanced phosphorylated AMPK-alpha1 more than fish oil and reduced the P65 via upregulation of Sirt-6 and downregulation of resistin, and resulted in attenuation of the inflammatory molecules P65, FFAs and TNF-alpha more than fish oil treated groups but in an insignificant statistical manner, those effects were accompanied by a substantial hypoglycemic effect.	gingerol	9-19	tumor necrosis factor	Rattus norvegicus	240-249
28113081-5	2017	CONCLUSION: Gingerol treatment effectively modulated the state of inflammatory privilege in HFD group and the metabolic disorders via targeting the AMPK-NF-kappaB pathway, through an increment in the SIRT-6 and substantial decrement in resistin levels.	gingerol	12-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	148-152
28113081-5	2017	CONCLUSION: Gingerol treatment effectively modulated the state of inflammatory privilege in HFD group and the metabolic disorders via targeting the AMPK-NF-kappaB pathway, through an increment in the SIRT-6 and substantial decrement in resistin levels.	gingerol	12-20	sirtuin 6	Rattus norvegicus	200-206
28065501-0	2017	Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.	gingerol	71-79	leukotriene A4 hydrolase	Homo sapiens	38-43
28093231-6	2017	6-gingerol showed beneficial effects in the EV induced PCOS rats via decreased expression of COX-2, restored biochemical parameters to normal and decreased of cysts in the ovaries.	gingerol	0-10	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	93-98
28065501-2	2017	[6]-gingerol, the major bioactive compound of Zingiber officinale, is a potential inhibitor of LTA4H, a highly expressed enzyme in colorectal carcinoma.	gingerol	0-12	leukotriene A4 hydrolase	Homo sapiens	95-100
28065501-6	2017	Furthermore [6]-gingerol derivatives showed potent LTA4H inhibitory activities in comparison to the universal positive controls (bestatin and 4BSA).	gingerol	16-24	leukotriene A4 hydrolase	Homo sapiens	51-56
28065501-7	2017	Among the natural gingerols, [10]-gingerol (N3) exhibited the highest LTA4H aminopeptidase and epoxide hydrolase inhibitory activities with IC50; 21.59 and 15.24muM, respectively.	gingerol	29-42	leukotriene A4 hydrolase	Homo sapiens	70-75
28065501-7	2017	Among the natural gingerols, [10]-gingerol (N3) exhibited the highest LTA4H aminopeptidase and epoxide hydrolase inhibitory activities with IC50; 21.59 and 15.24muM, respectively.	gingerol	29-42	carboxypeptidase Q	Homo sapiens	76-90
29199237-0	2017	Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development.	gingerol	55-65	chemokine (C-X-C motif) ligand 1	Mus musculus	114-119
27525509-2	2017	6-Gingerol decreased adipogenesis due to the suppression of adipocyte differentiation markers, including peroxisome proliferator-activated receptor gamma, CCAATT enhancer binding protein alpha, and adipocyte protein 2, and triglyceride synthesis enzymes, including sterol regulatory element-binding protein-1, fatty acid synthase, lysophosphatidic acid acyltransferase, and acyl-coA : diacylglycerol acyltransferase 1, in 3T3-L1.	gingerol	0-10	peroxisome proliferator-activated receptor gamma	Danio rerio	105-153
27525509-2	2017	6-Gingerol decreased adipogenesis due to the suppression of adipocyte differentiation markers, including peroxisome proliferator-activated receptor gamma, CCAATT enhancer binding protein alpha, and adipocyte protein 2, and triglyceride synthesis enzymes, including sterol regulatory element-binding protein-1, fatty acid synthase, lysophosphatidic acid acyltransferase, and acyl-coA : diacylglycerol acyltransferase 1, in 3T3-L1.	gingerol	0-10	sterol regulatory element binding transcription factor 1	Danio rerio	265-308
27525509-2	2017	6-Gingerol decreased adipogenesis due to the suppression of adipocyte differentiation markers, including peroxisome proliferator-activated receptor gamma, CCAATT enhancer binding protein alpha, and adipocyte protein 2, and triglyceride synthesis enzymes, including sterol regulatory element-binding protein-1, fatty acid synthase, lysophosphatidic acid acyltransferase, and acyl-coA : diacylglycerol acyltransferase 1, in 3T3-L1.	gingerol	0-10	fatty acid synthase	Danio rerio	310-329
27525509-3	2017	A coculture insert system using 3T3-L1 with RAW 264.7 (coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages) revealed that 6-gingerol increased anti-inflammatory cytokine interleukin-10.	gingerol	161-171	interleukin 10	Mus musculus	209-223
27525509-4	2017	The expression of TNFalpha, monocyte chemotactic protein-1, interleukin-1beta, and interleukin-6 were decreased in the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages treated with 6-gingerol.	gingerol	223-233	tumor necrosis factor	Mus musculus	18-26
27525509-4	2017	The expression of TNFalpha, monocyte chemotactic protein-1, interleukin-1beta, and interleukin-6 were decreased in the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages treated with 6-gingerol.	gingerol	223-233	chemokine (C-C motif) ligand 2	Mus musculus	28-58
27525509-4	2017	The expression of TNFalpha, monocyte chemotactic protein-1, interleukin-1beta, and interleukin-6 were decreased in the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages treated with 6-gingerol.	gingerol	223-233	interleukin 6	Mus musculus	83-96
27525509-5	2017	Moreover, the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages treated with 6-gingerol inhibited the protein expression of TNFalpha and monocyte chemotactic protein-1 in RAW 264.7.	gingerol	118-128	tumor necrosis factor	Mus musculus	165-173
27525509-5	2017	Moreover, the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages treated with 6-gingerol inhibited the protein expression of TNFalpha and monocyte chemotactic protein-1 in RAW 264.7.	gingerol	118-128	chemokine (C-C motif) ligand 2	Mus musculus	178-208
27525509-6	2017	6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta and its downstream target AP-1 expression in the coculture insert system using fully differentiated 3T3-L1 cells with RAW 264.7 macrophages.	gingerol	0-10	inhibitor of kappaB kinase beta	Mus musculus	49-70
27525509-8	2017	Our results suggest that 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets.	gingerol	25-35	inhibitor of kappaB kinase beta	Mus musculus	114-135
29199237-12	2017	Nuclear factor kappa B (NF-kappaB) was activated by 5-FU treatment in cultured colon tissue, which was also suppressed by HST and the combination of baicalein and 6-gingerol.	gingerol	163-173	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-22
29199237-12	2017	Nuclear factor kappa B (NF-kappaB) was activated by 5-FU treatment in cultured colon tissue, which was also suppressed by HST and the combination of baicalein and 6-gingerol.	gingerol	163-173	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-33
29199237-15	2017	These findings suggest that HST, especially baicalein and 6-gingerol, prevent the development of neutrophil recruitment and diarrhea by the inhibition of NF-kappaB activity.	gingerol	58-68	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	154-163
27685794-0	2016	In vitro and in vivo inhibition of aldose reductase and advanced glycation end products by phloretin, epigallocatechin 3-gallate and [6]-gingerol.	gingerol	133-145	aldo-keto reductase family 1 member B	Homo sapiens	35-51
27685794-2	2016	In this study the therapeutic potential of phloretin, epigallocatechin 3-gallate (EGCG) and [6]-gingerol were evaluated for anti-glycating and AR inhibitory activity in vitro and in vivo systems.	gingerol	92-104	aldo-keto reductase family 1 member B	Homo sapiens	143-145
27685794-8	2016	Pre-treatment of cells with phloretin, EGCG and [6]-gingerol improved cell viability and inhibited AR activity.	gingerol	48-60	aldo-keto reductase family 1 member B	Homo sapiens	99-101
27685794-9	2016	The enzyme inhibition kinetics followed a non-competitive mode of inhibition for phloretin and EGCG whereas [6]-gingerol indicated uncompetitive type of inhibition against AR.	gingerol	108-120	aldo-keto reductase family 1 member B	Homo sapiens	172-174
27685794-12	2016	Administration of EGCG, phloretin and [6]-gingerol significantly reduced blood sugar levels, AGEs accumulation, and AR activity.	gingerol	38-50	aldo-keto reductase family 1 member B	Homo sapiens	116-118