PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14563495-0	2003	Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression.	fangchinoline	0-13	mitogen activated protein kinase 3	Rattus norvegicus	125-131
16204959-1	2005	We examined the ability of partially synthesized new compounds from fangchinoline and tetrandrine to reverse P-glycoprotein (P-gp)-dependent multidrug resistance (MDR) in vitro and in vivo.	fangchinoline	68-81	phosphoglycolate phosphatase	Mus musculus	109-123
16204959-1	2005	We examined the ability of partially synthesized new compounds from fangchinoline and tetrandrine to reverse P-glycoprotein (P-gp)-dependent multidrug resistance (MDR) in vitro and in vivo.	fangchinoline	68-81	phosphoglycolate phosphatase	Mus musculus	125-129
18330294-0	2007	[Study on the interaction between fangchinoline and bovine serum albumin].	fangchinoline	34-47	albumin	Homo sapiens	59-73
18330294-1	2007	The binding reaction of fangchinoline with bovine serum albumin was studied at different temperatures by fluorescence quenching spectra, synchronous fluorescence spectra and ultra-violet spectra.	fangchinoline	24-37	albumin	Homo sapiens	56-63
14563495-0	2003	Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression.	fangchinoline	0-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	147-152
12608643-14	2003	CONCLUSIONS: The result suggest that fangchinoline due mainly to its ability to downregulate TNF-alpha production might have protective effect in murine models of zymosan-induced MODS and E. coli-induced septic shock.	fangchinoline	37-50	tumor necrosis factor	Mus musculus	93-102
10687873-6	2000	However, 4 microM of fangchinoline and 6 microM of tetrandrine showed 63 and 86% of inhibitions on hIL-6 activity, respectively.	fangchinoline	21-34	interleukin 6	Homo sapiens	99-104
34195076-0	2021	Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis.	fangchinoline	0-13	activating transcription factor 4	Homo sapiens	66-70
9625436-0	1998	The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein.	fangchinoline	52-65	ATP binding cassette subfamily B member 1	Homo sapiens	148-162
8824940-2	1995	This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflammatory cytokines, interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-alpha), by Staphylococcus aureus Cowan 1 (SAC)-stimulated human peripheral blood mononuclear cells.	fangchinoline	76-89	tumor necrosis factor	Homo sapiens	216-225
34486935-5	2021	Following computational approaches, we identified fangchinoline and versicolactone C as the compounds to exhibit strong binding to the target proteins and causing structural deformation of three structural proteins (N, S and M).	fangchinoline	50-63	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	219-220
34195076-0	2021	Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis.	fangchinoline	0-13	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	87-91
34195076-0	2021	Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis.	fangchinoline	0-13	TNF receptor superfamily member 10b	Homo sapiens	116-119
34195076-5	2021	Mechanistic studies revealed that FCL-induced G1 phase cell-cycle arrest in ESCC which is dependent on p21 and p27.	fangchinoline	34-37	H3 histone pseudogene 16	Homo sapiens	103-106
34195076-5	2021	Mechanistic studies revealed that FCL-induced G1 phase cell-cycle arrest in ESCC which is dependent on p21 and p27.	fangchinoline	34-37	dynactin subunit 6	Homo sapiens	111-114
34195076-6	2021	Moreover, we found that FCL coordinatively triggered Noxa-dependent intrinsic apoptosis and DR5-dependent extrinsic apoptosis by transactivating ATF4, which is a novel mechanism.	fangchinoline	24-27	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	53-57
34195076-6	2021	Moreover, we found that FCL coordinatively triggered Noxa-dependent intrinsic apoptosis and DR5-dependent extrinsic apoptosis by transactivating ATF4, which is a novel mechanism.	fangchinoline	24-27	TNF receptor superfamily member 10b	Homo sapiens	92-95
34195076-6	2021	Moreover, we found that FCL coordinatively triggered Noxa-dependent intrinsic apoptosis and DR5-dependent extrinsic apoptosis by transactivating ATF4, which is a novel mechanism.	fangchinoline	24-27	activating transcription factor 4	Homo sapiens	145-149
35621239-11	2022	However, FCN markedly enhanced the expression of epithelial markers such as occludin and E-cadherin.	fangchinoline	9-12	occludin	Homo sapiens	76-84
35621239-11	2022	However, FCN markedly enhanced the expression of epithelial markers such as occludin and E-cadherin.	fangchinoline	9-12	cadherin 1	Homo sapiens	89-99
35446864-0	2022	Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	76-79
35563670-2	2022	In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells.	fangchinoline	42-55	nuclear receptor subfamily 4 group A member 1	Homo sapiens	94-99
35563670-2	2022	In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells.	fangchinoline	42-55	nuclear receptor subfamily 4 group A member 1	Homo sapiens	109-114
35563670-2	2022	In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells.	fangchinoline	57-60	nuclear receptor subfamily 4 group A member 1	Homo sapiens	94-99
35563670-2	2022	In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells.	fangchinoline	57-60	nuclear receptor subfamily 4 group A member 1	Homo sapiens	109-114
35563670-3	2022	In this study, we evaluated FCN and its structural analogs (berbamine, isotetrandrine, tetrandrine, and tubocurarine) for their inhibitory effects on NR4A1 transactivity, and confirmed that tetrandrine (TTD) showed the highest inhibitory effect in pancreatic cancer cells.	fangchinoline	28-31	nuclear receptor subfamily 4 group A member 1	Homo sapiens	150-155
35446864-0	2022	Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.	fangchinoline	0-13	X-linked inhibitor of apoptosis	Homo sapiens	80-84
35446864-5	2022	Further studies found that an anti-apoptotic pathway, the PI3K/Akt/XIAP axis, was significantly inhibited in GBC cells after treating with fangchinoline.	fangchinoline	139-152	AKT serine/threonine kinase 1	Homo sapiens	63-66
35446864-5	2022	Further studies found that an anti-apoptotic pathway, the PI3K/Akt/XIAP axis, was significantly inhibited in GBC cells after treating with fangchinoline.	fangchinoline	139-152	X-linked inhibitor of apoptosis	Homo sapiens	67-71
35176991-0	2022	Fangchinoline inhibited proliferation of neoplastic B-lymphoid cells and alleviated Sjogren"s syndrome-like responses in NOD/Ltj mice via the Akt/mTOR pathway.	fangchinoline	0-13	thymoma viral proto-oncogene 1	Mus musculus	142-145
35176991-0	2022	Fangchinoline inhibited proliferation of neoplastic B-lymphoid cells and alleviated Sjogren"s syndrome-like responses in NOD/Ltj mice via the Akt/mTOR pathway.	fangchinoline	0-13	mechanistic target of rapamycin kinase	Mus musculus	146-150
35176991-3	2022	OBJECTIVE: This study aimed to identify the potential role of Fangchinoline in the treatment of SS via altering Akt/mTOR signaling.	fangchinoline	62-75	AKT serine/threonine kinase 1	Homo sapiens	112-115
35176991-3	2022	OBJECTIVE: This study aimed to identify the potential role of Fangchinoline in the treatment of SS via altering Akt/mTOR signaling.	fangchinoline	62-75	mechanistic target of rapamycin kinase	Homo sapiens	116-120
35176991-10	2022	In vitro, Fangchinoline and LY294002 inhibited proliferation, induced cell cycle arrest, and promoted apoptosis in Raji and Daudi cells by altering Akt/mTOR signaling.	fangchinoline	10-23	AKT serine/threonine kinase 1	Homo sapiens	148-151
35176991-10	2022	In vitro, Fangchinoline and LY294002 inhibited proliferation, induced cell cycle arrest, and promoted apoptosis in Raji and Daudi cells by altering Akt/mTOR signaling.	fangchinoline	10-23	mechanistic target of rapamycin kinase	Homo sapiens	152-156
35024200-0	2022	Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model.	fangchinoline	0-13	signal transducer and activator of transcription 3	Homo sapiens	25-30
35163790-5	2022	In the present study, we identified natural compounds with higher docking scores than the known Aurora A ligand through structure-based virtual screening, including the natural compound fangchinoline, which has been associated with anticancer activities but not yet investigated in ovarian cancer.	fangchinoline	186-199	aurora kinase A	Homo sapiens	96-104
35163790-6	2022	The binding and inhibition of Aurora A by fangchinoline were verified using cellular thermal shift and enzyme activity assays.	fangchinoline	42-55	aurora kinase A	Homo sapiens	30-38
35163790-11	2022	This study reveals a novel Aurora A inhibitor, fangchinoline, as a potentially viable adjuvant for ovarian cancer therapy.	fangchinoline	47-60	aurora kinase A	Homo sapiens	27-35
35024200-0	2022	Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model.	fangchinoline	0-13	nuclear receptor subfamily 0 group B member 2	Homo sapiens	88-93
35024200-3	2022	Objectives: Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogenic STAT3 signaling pathway using diverse tumor cell lines and a xenograft mouse model.	fangchinoline	45-58	signal transducer and activator of transcription 3	Mus musculus	136-141
35024200-3	2022	Objectives: Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogenic STAT3 signaling pathway using diverse tumor cell lines and a xenograft mouse model.	fangchinoline	60-63	signal transducer and activator of transcription 3	Mus musculus	136-141
35024200-10	2022	In addition, FCN also attenuated DNA binding ability of STAT3 and its translocation into the nucleus.	fangchinoline	13-16	signal transducer and activator of transcription 3	Mus musculus	56-61
33828201-0	2021	Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway.	fangchinoline	0-13	KH-type splicing regulatory protein	Homo sapiens	67-72
33828201-5	2021	Further mechanistic experiments indicated that fangchinoline suppressed the homologous recombination (HR)-directed DNA repair by binding with far upstream element binding protein 2 (FUBP2) and downregulating the expression of HR factors BRCA1 and RAD51.	fangchinoline	47-60	KH-type splicing regulatory protein	Homo sapiens	142-180
33828201-5	2021	Further mechanistic experiments indicated that fangchinoline suppressed the homologous recombination (HR)-directed DNA repair by binding with far upstream element binding protein 2 (FUBP2) and downregulating the expression of HR factors BRCA1 and RAD51.	fangchinoline	47-60	KH-type splicing regulatory protein	Homo sapiens	182-187
33828201-5	2021	Further mechanistic experiments indicated that fangchinoline suppressed the homologous recombination (HR)-directed DNA repair by binding with far upstream element binding protein 2 (FUBP2) and downregulating the expression of HR factors BRCA1 and RAD51.	fangchinoline	47-60	BRCA1 DNA repair associated	Homo sapiens	237-242
33828201-5	2021	Further mechanistic experiments indicated that fangchinoline suppressed the homologous recombination (HR)-directed DNA repair by binding with far upstream element binding protein 2 (FUBP2) and downregulating the expression of HR factors BRCA1 and RAD51.	fangchinoline	47-60	RAD51 recombinase	Homo sapiens	247-252
33609560-0	2021	Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK/mTOR/ULK1 pathway.	fangchinoline	0-13	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	98-102
33609560-0	2021	Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK/mTOR/ULK1 pathway.	fangchinoline	0-13	mechanistic target of rapamycin kinase	Homo sapiens	103-107
33609560-0	2021	Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK/mTOR/ULK1 pathway.	fangchinoline	0-13	unc-51 like autophagy activating kinase 1	Homo sapiens	108-112
33416119-0	2021	Fangchinoline exerts antitumour activity by suppressing the EGFR-PI3K/AKT signalling pathway in colon adenocarcinoma.	fangchinoline	0-13	epidermal growth factor receptor	Homo sapiens	60-64
33416119-0	2021	Fangchinoline exerts antitumour activity by suppressing the EGFR-PI3K/AKT signalling pathway in colon adenocarcinoma.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	70-73
32713853-0	2020	Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1beta-Stimulated Human FLS Cells.	fangchinoline	0-13	interleukin 1 alpha	Homo sapiens	71-79
33327436-7	2020	Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition.	fangchinoline	21-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
33327436-7	2020	Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition.	fangchinoline	21-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
33327436-10	2020	The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5.	fangchinoline	24-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-93
33327436-11	2020	Furthermore, the molecular docking results showed that fangchinoline bound with AChE residues in the peripheral anionic site, and cyclanoline bound with AChE residues in the peripheral anionic site, anionic site, and catalytic site.	fangchinoline	55-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
33327436-13	2020	The results support that fangchinoline and cyclanoline, alkaloids derived from STR, could account for the anti-AChE function of STR.	fangchinoline	25-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
33241016-0	2020	Fangchinoline attenuates cardiac dysfunction in rats with endotoxemia via the inhibition of ERK1/2 and NF-kappaB p65 phosphorylation.	fangchinoline	0-13	mitogen activated protein kinase 3	Rattus norvegicus	92-98
30739905-0	2019	Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kappaB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats.	fangchinoline	0-13	advanced glycosylation end product-specific receptor	Rattus norvegicus	61-105
30049003-8	2020	Immunohistochemical analyses also revealed that treatment with fangchinoline significantly reduced the expression of collagen IV and CD31 in the kidneys compared to the control group.	fangchinoline	63-76	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	133-137
30049003-9	2020	The expression of p38 MAPK, TNF-alpha, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats.	fangchinoline	79-92	mitogen activated protein kinase 14	Rattus norvegicus	18-21
30049003-9	2020	The expression of p38 MAPK, TNF-alpha, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats.	fangchinoline	79-92	tumor necrosis factor	Rattus norvegicus	28-37
30049003-9	2020	The expression of p38 MAPK, TNF-alpha, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats.	fangchinoline	79-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	39-44
30049003-9	2020	The expression of p38 MAPK, TNF-alpha, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats.	fangchinoline	79-92	matrix metallopeptidase 9	Rattus norvegicus	50-55
30049003-10	2020	Together, the results of this study suggest that fangchinoline protects against nephron damage by attenuating alterations in the p38 MAPK pathway, thereby reducing oxidative stress and inflammation in DN rats.	fangchinoline	49-62	mitogen activated protein kinase 14	Rattus norvegicus	129-132
32201213-3	2020	Here, we revealed that fangchinoline (FCL), an active alkaloid that purified from the traditional Chinese medicine Stephania tetrandra S. Moore, enhanced the anti-lung cancer effect of mTOR inhibitor everolimus (EVE).	fangchinoline	23-36	mechanistic target of rapamycin kinase	Homo sapiens	185-189
32201213-3	2020	Here, we revealed that fangchinoline (FCL), an active alkaloid that purified from the traditional Chinese medicine Stephania tetrandra S. Moore, enhanced the anti-lung cancer effect of mTOR inhibitor everolimus (EVE).	fangchinoline	38-41	mechanistic target of rapamycin kinase	Homo sapiens	185-189
31847089-3	2019	Fangchinoline from STR and coptisine and/or berberine from CR and/or PCC are active alkaloids in inhibiting AChE.	fangchinoline	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
31847089-4	2019	The traditional usage of paired herbs suggests the synergistic effect of fangchinoline-coptisine or fangchinoline-berberine pairing in AChE inhibition.	fangchinoline	100-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
31847089-8	2019	It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE.	fangchinoline	18-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
31847089-8	2019	It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE.	fangchinoline	77-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
31847089-8	2019	It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE.	fangchinoline	77-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
31270710-0	2019	Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.	fangchinoline	43-56	kelch-like ECH-associated protein 1	Mus musculus	110-115
31270710-0	2019	Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.	fangchinoline	43-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
31660888-0	2019	Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.	fangchinoline	103-116	BLM RecQ like helicase	Homo sapiens	142-145
31466313-0	2019	Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-kappaB and AP-1 Pathways.	fangchinoline	0-13	nuclear factor kappa B subunit 1	Homo sapiens	116-125
31466313-0	2019	Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-kappaB and AP-1 Pathways.	fangchinoline	0-13	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
31466313-3	2019	Nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells.	fangchinoline	145-148	nuclear factor kappa B subunit 1	Homo sapiens	0-21
31466313-3	2019	Nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumor cells.	fangchinoline	145-148	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-63
31466313-5	2019	FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-kappaB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IkappaB kinase (IKK) and p65.	fangchinoline	0-3	nuclear factor kappa B subunit 1	Homo sapiens	80-89
31466313-5	2019	FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-kappaB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IkappaB kinase (IKK) and p65.	fangchinoline	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-99
31466313-5	2019	FCN attenuated growth of both leukemic and multiple myeloma cells and repressed NF-kappaB, and AP-1 activation through diverse mechanisms, including attenuation of phosphorylation of IkappaB kinase (IKK) and p65.	fangchinoline	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	208-211
31466313-6	2019	Furthermore, FCN could also cause significant enhancement in TNFalpha-driven apoptosis as studied by various molecular techniques.	fangchinoline	13-16	tumor necrosis factor	Homo sapiens	61-69
31784186-0	2020	Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	122-125
31929758-0	2020	Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling.	fangchinoline	0-13	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	110-115
31929758-6	2020	We found that fangchinoline down regulated NFATc1 activity and expression.	fangchinoline	14-27	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	43-49
30579253-5	2019	Lipid peroxidation, GSH, SOD, catalase, and Gpx levels recovered to near normal levels by fangchinoline treatment.	fangchinoline	90-103	catalase	Rattus norvegicus	30-38
30579253-6	2019	Fangchinoline treatment significantly reduced the TNF-alpha level by 17.8% and 40.8% in groups III and IV respectively, whereas IL-6 was significantly decreased by 23.2% and 45%, respectively.	fangchinoline	0-13	tumor necrosis factor	Rattus norvegicus	50-59
30579253-7	2019	Fangchinoline treatment significantly decreased the MMP-3 level by 23.1% and 65.1% in groups III and IV respectively, whereas PGE2 was significantly decreased by 31.8% and 63.8%, respectively.	fangchinoline	0-13	matrix metallopeptidase 3	Rattus norvegicus	52-57
30579253-8	2019	Fangchinoline treatment decreased NO, uric acid, ceruloplasmin, and copper levels, whereas the zinc content was increased.	fangchinoline	0-13	ceruloplasmin	Rattus norvegicus	49-62
30579253-11	2019	Protein expression of TNF-alpha was significantly decreased by 0.27-, 0.53-, and 0.67-fold at 2 muM, 4 muM, and 6 muM fangchinoline treatment respectively.	fangchinoline	118-131	tumor necrosis factor	Rattus norvegicus	22-31
30391811-8	2019	As a result, epiberberine and fangchinoline with certain ACE inhibitory activities were screened out in the assay and validated.	fangchinoline	30-43	angiotensin I converting enzyme	Homo sapiens	57-60
30739905-0	2019	Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kappaB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats.	fangchinoline	0-13	advanced glycosylation end product-specific receptor	Rattus norvegicus	107-111
30739905-10	2019	Moreover, treatment with fangchinoline attenuated the altered retinal morphology and expression of inflammatory mediators and RAGE in the retinal tissues of DR rats.	fangchinoline	25-38	advanced glycosylation end product-specific receptor	Rattus norvegicus	126-130
30739905-12	2019	CONCLUSIONS Our investigation shows that fangchinoline attenuates the apoptosis of retinal cells in STZ-induced diabetic retinopathy rats by inhibiting the RAGE/NF-kappaB pathway.	fangchinoline	41-54	advanced glycosylation end product-specific receptor	Rattus norvegicus	156-160
30687543-6	2018	Results: Result of this investigation reveals that the percentage of brain injury significantly reduces and enhancement of myelin basic protein in the cerebral tissues of fangchinoline than ischemic group.	fangchinoline	171-184	myelin basic protein	Rattus norvegicus	123-143
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	annexin A3	Rattus norvegicus	86-89
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	BCL2, apoptosis regulator	Rattus norvegicus	91-96
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	caspase 3	Rattus norvegicus	98-107
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	bone morphogenetic protein 2	Rattus norvegicus	109-113
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	beclin 1	Rattus norvegicus	115-123
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	autophagy related 5	Rattus norvegicus	125-130
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	RUNX family transcription factor 2	Rattus norvegicus	132-138
30632520-9	2019	We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats.	fangchinoline	34-47	TNF superfamily member 11	Rattus norvegicus	144-149
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	nitric oxide synthase 2	Rattus norvegicus	58-62
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	vascular endothelial growth factor A	Rattus norvegicus	65-99
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	vascular endothelial growth factor A	Rattus norvegicus	101-105
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	108-111
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-141
30687543-8	2018	Moreover expressions of inducible nitric oxide synthtase (iNOS), vascular endothelial growth factor (VEGF), p53 and nuclear receptor factor-2 (Nrf2) in the brain tissue attenuated by fangchinoline treated group.	fangchinoline	183-196	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
28754437-0	2017	Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells.	fangchinoline	88-101	nuclear receptor subfamily 4 group A member 1	Homo sapiens	44-49
28754437-2	2017	In the present study, we identified fangchinoline, a bisbenzyltetrahydroisoquinoline alkaloid from Stephania tetrandra, as a new inactivator of nuclear NR4A1 and demonstrated that fangchinoline inhibits cell proliferation and induces apoptosis, in part, via the NR4A1-dependent pro-apoptotic pathways in human pancreatic cancer cells.	fangchinoline	180-193	nuclear receptor subfamily 4 group A member 1	Homo sapiens	262-267
28754437-4	2017	These results suggest that inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline, and fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.	fangchinoline	123-136	nuclear receptor subfamily 4 group A member 1	Homo sapiens	41-46
28754437-2	2017	In the present study, we identified fangchinoline, a bisbenzyltetrahydroisoquinoline alkaloid from Stephania tetrandra, as a new inactivator of nuclear NR4A1 and demonstrated that fangchinoline inhibits cell proliferation and induces apoptosis, in part, via the NR4A1-dependent pro-apoptotic pathways in human pancreatic cancer cells.	fangchinoline	36-49	nuclear receptor subfamily 4 group A member 1	Homo sapiens	152-157
28754437-4	2017	These results suggest that inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline, and fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.	fangchinoline	123-136	nuclear receptor subfamily 4 group A member 1	Homo sapiens	228-233
28754437-4	2017	These results suggest that inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline, and fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.	fangchinoline	142-155	nuclear receptor subfamily 4 group A member 1	Homo sapiens	228-233
28754437-2	2017	In the present study, we identified fangchinoline, a bisbenzyltetrahydroisoquinoline alkaloid from Stephania tetrandra, as a new inactivator of nuclear NR4A1 and demonstrated that fangchinoline inhibits cell proliferation and induces apoptosis, in part, via the NR4A1-dependent pro-apoptotic pathways in human pancreatic cancer cells.	fangchinoline	36-49	nuclear receptor subfamily 4 group A member 1	Homo sapiens	262-267
28586029-10	2017	Fangchinoline-treated MG63 cells showed significantly decreased expression of phosphoinositide 3-kinase (PI3K) and Aktp-Thr308.	fangchinoline	0-13	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	78-103
28586029-11	2017	Moreover, fangchinoline-treated MG63 cells showed downregulated expression of cyclin D1 and matrix metalloproteinase 2 and 9, which act downstream of PI3K, and upregulated expression of caspase-3 and caspase-8.	fangchinoline	10-23	cyclin D1	Homo sapiens	78-87
28586029-11	2017	Moreover, fangchinoline-treated MG63 cells showed downregulated expression of cyclin D1 and matrix metalloproteinase 2 and 9, which act downstream of PI3K, and upregulated expression of caspase-3 and caspase-8.	fangchinoline	10-23	matrix metallopeptidase 2	Homo sapiens	92-124
28586029-11	2017	Moreover, fangchinoline-treated MG63 cells showed downregulated expression of cyclin D1 and matrix metalloproteinase 2 and 9, which act downstream of PI3K, and upregulated expression of caspase-3 and caspase-8.	fangchinoline	10-23	caspase 3	Homo sapiens	186-195
28586029-11	2017	Moreover, fangchinoline-treated MG63 cells showed downregulated expression of cyclin D1 and matrix metalloproteinase 2 and 9, which act downstream of PI3K, and upregulated expression of caspase-3 and caspase-8.	fangchinoline	10-23	caspase 8	Homo sapiens	200-209
28560386-0	2017	Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	102-105
28560386-7	2017	We also found that fangchinoline could significantly reduce the phosphorylation of Focal adhesion kinase (FAK).	fangchinoline	19-32	protein tyrosine kinase 2	Homo sapiens	83-104
28560386-7	2017	We also found that fangchinoline could significantly reduce the phosphorylation of Focal adhesion kinase (FAK).	fangchinoline	19-32	protein tyrosine kinase 2	Homo sapiens	106-109
28560386-8	2017	In summary, we demonstrated that fangchinoline inhibits the proliferation and metastasis of melanoma cells by suppressing FAK and its downstream signaling pathway.	fangchinoline	33-46	protein tyrosine kinase 2	Homo sapiens	122-125
26408176-0	2016	Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	114-117
28356942-5	2017	Our results also indicated that FCL repressed the phosphorylation of AKT in gastric cancer AGS cells.	fangchinoline	32-35	AKT serine/threonine kinase 1	Homo sapiens	69-72
28356942-6	2017	In summary, FCL may exert its anti-metastatic property in human gastric cancer cells in vitro by suppression of MMP-2 and MMP-9, increase of TIMP1 and TIMP2 genes, and inhibition of AKT phosphorylation.	fangchinoline	12-15	matrix metallopeptidase 2	Homo sapiens	112-117
28356942-6	2017	In summary, FCL may exert its anti-metastatic property in human gastric cancer cells in vitro by suppression of MMP-2 and MMP-9, increase of TIMP1 and TIMP2 genes, and inhibition of AKT phosphorylation.	fangchinoline	12-15	matrix metallopeptidase 9	Homo sapiens	122-127
28356942-6	2017	In summary, FCL may exert its anti-metastatic property in human gastric cancer cells in vitro by suppression of MMP-2 and MMP-9, increase of TIMP1 and TIMP2 genes, and inhibition of AKT phosphorylation.	fangchinoline	12-15	TIMP metallopeptidase inhibitor 1	Homo sapiens	141-146
28356942-6	2017	In summary, FCL may exert its anti-metastatic property in human gastric cancer cells in vitro by suppression of MMP-2 and MMP-9, increase of TIMP1 and TIMP2 genes, and inhibition of AKT phosphorylation.	fangchinoline	12-15	TIMP metallopeptidase inhibitor 2	Homo sapiens	151-156
28356942-6	2017	In summary, FCL may exert its anti-metastatic property in human gastric cancer cells in vitro by suppression of MMP-2 and MMP-9, increase of TIMP1 and TIMP2 genes, and inhibition of AKT phosphorylation.	fangchinoline	12-15	AKT serine/threonine kinase 1	Homo sapiens	182-185
28968601-7	2017	Fcn treatment induced both apoptosis and autophagy in bladder cancer cells, as shown by the increased cleavage of caspase-3, an up-regulated LC3-II/LC3-I ratio and the down-regulated p62 level.	fangchinoline	0-3	caspase 3	Homo sapiens	114-123
28968601-7	2017	Fcn treatment induced both apoptosis and autophagy in bladder cancer cells, as shown by the increased cleavage of caspase-3, an up-regulated LC3-II/LC3-I ratio and the down-regulated p62 level.	fangchinoline	0-3	nucleoporin 62	Homo sapiens	183-186
28968601-9	2017	Additionally, we observed that Fcn treatment inhibited mTOR and reduced the intracellular ATP levels.	fangchinoline	31-34	mechanistic target of rapamycin kinase	Homo sapiens	55-59
26408176-5	2016	We also observed that fangchinoline inhibits tumor cell proliferation and invasiveness and induces apoptosis through suppressing the Akt-mediated signaling cascades, including Akt/p21, Akt/Bad, and Akt/matrix metalloproteinases (MMPs).	fangchinoline	22-35	H3 histone pseudogene 16	Homo sapiens	180-183
26408176-5	2016	We also observed that fangchinoline inhibits tumor cell proliferation and invasiveness and induces apoptosis through suppressing the Akt-mediated signaling cascades, including Akt/p21, Akt/Bad, and Akt/matrix metalloproteinases (MMPs).	fangchinoline	22-35	AKT serine/threonine kinase 1	Homo sapiens	176-179
26408176-5	2016	We also observed that fangchinoline inhibits tumor cell proliferation and invasiveness and induces apoptosis through suppressing the Akt-mediated signaling cascades, including Akt/p21, Akt/Bad, and Akt/matrix metalloproteinases (MMPs).	fangchinoline	22-35	AKT serine/threonine kinase 1	Homo sapiens	176-179
26408176-6	2016	These data demonstrated that fangchinoline exerts its anti-tumor effects in human glioblastoma cells, at least partly by inhibiting the kinase activity of Akt and suppressing Akt-mediated signaling cascades.	fangchinoline	29-42	AKT serine/threonine kinase 1	Homo sapiens	155-158
26408176-0	2016	Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	122-125
26408176-6	2016	These data demonstrated that fangchinoline exerts its anti-tumor effects in human glioblastoma cells, at least partly by inhibiting the kinase activity of Akt and suppressing Akt-mediated signaling cascades.	fangchinoline	29-42	AKT serine/threonine kinase 1	Homo sapiens	175-178
26408176-4	2016	In this study, two WHO grade IV human GBM cell lines (U87 MG and U118 MG) were exposed to fangchinoline, and we found that fangchinoline specifically inhibits the kinase activity of Akt and markedly suppresses the phosphorylation of Thr308 and Ser473 of Akt in human GBM cells.	fangchinoline	123-136	AKT serine/threonine kinase 1	Homo sapiens	182-185
26408176-4	2016	In this study, two WHO grade IV human GBM cell lines (U87 MG and U118 MG) were exposed to fangchinoline, and we found that fangchinoline specifically inhibits the kinase activity of Akt and markedly suppresses the phosphorylation of Thr308 and Ser473 of Akt in human GBM cells.	fangchinoline	123-136	AKT serine/threonine kinase 1	Homo sapiens	254-257
26408176-5	2016	We also observed that fangchinoline inhibits tumor cell proliferation and invasiveness and induces apoptosis through suppressing the Akt-mediated signaling cascades, including Akt/p21, Akt/Bad, and Akt/matrix metalloproteinases (MMPs).	fangchinoline	22-35	AKT serine/threonine kinase 1	Homo sapiens	133-136
26408176-5	2016	We also observed that fangchinoline inhibits tumor cell proliferation and invasiveness and induces apoptosis through suppressing the Akt-mediated signaling cascades, including Akt/p21, Akt/Bad, and Akt/matrix metalloproteinases (MMPs).	fangchinoline	22-35	AKT serine/threonine kinase 1	Homo sapiens	176-179
26512898-0	2015	Inhibition on Proteasome beta1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells.	fangchinoline	86-99	proteasome 20S subunit beta 1	Homo sapiens	14-38
26512898-2	2015	Fangchinoline and its structure analogue, tetrandrine, exhibited direct binding affinity with recombinant human proteasome beta1 subunit and also inhibited its activity in vitro.	fangchinoline	0-13	proteasome 20S subunit beta 1	Homo sapiens	112-136
26512898-3	2015	In cultured prostate PC-3 cells and LnCap cells, fangchinoline could dose-dependently inhibit cell proliferation and caspase-like activity of cellular proteasome which was mediated by proteasome beta1 subunit.	fangchinoline	49-62	proteasome 20S subunit beta 1	Homo sapiens	184-208
26512898-7	2015	Dose-dependent and time-dependent accumulation of ubiquitinated proteins and important proteasome substrates such as p27, Bax and IkappaB-alpha were observed in fangchinoline-treated cells.	fangchinoline	161-174	interferon alpha inducible protein 27	Homo sapiens	117-120
26512898-7	2015	Dose-dependent and time-dependent accumulation of ubiquitinated proteins and important proteasome substrates such as p27, Bax and IkappaB-alpha were observed in fangchinoline-treated cells.	fangchinoline	161-174	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
26512898-7	2015	Dose-dependent and time-dependent accumulation of ubiquitinated proteins and important proteasome substrates such as p27, Bax and IkappaB-alpha were observed in fangchinoline-treated cells.	fangchinoline	161-174	NFKB inhibitor alpha	Homo sapiens	130-143
26512898-8	2015	Over-expression of proteasome beta1 subunit by plasmid transfection increased sensitivity of cells to the cytotoxicity of fangchinoline while knockdown of proteasome beta1 subunit ameliorated cytotoxicity of fangchinoline in PC-3 cells.	fangchinoline	122-135	proteasome 20S subunit beta 1	Homo sapiens	19-43
26512898-8	2015	Over-expression of proteasome beta1 subunit by plasmid transfection increased sensitivity of cells to the cytotoxicity of fangchinoline while knockdown of proteasome beta1 subunit ameliorated cytotoxicity of fangchinoline in PC-3 cells.	fangchinoline	208-221	proteasome 20S subunit beta 1	Homo sapiens	19-43
26512898-8	2015	Over-expression of proteasome beta1 subunit by plasmid transfection increased sensitivity of cells to the cytotoxicity of fangchinoline while knockdown of proteasome beta1 subunit ameliorated cytotoxicity of fangchinoline in PC-3 cells.	fangchinoline	208-221	proteasome 20S subunit beta 1	Homo sapiens	155-179
26512898-10	2015	Fangchinoline and its structure analogues might be new natural proteasome inhibitors targeting beta1 subunit.	fangchinoline	0-13	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	95-100
25539072-0	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	44-47
25539072-0	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66
25539072-5	2015	RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines.	fangchinoline	9-22	protein tyrosine kinase 2	Homo sapiens	180-183
25539072-5	2015	RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines.	fangchinoline	9-22	protein tyrosine kinase 2	Homo sapiens	260-263
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	8-11
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	matrix metallopeptidase 2	Homo sapiens	21-25
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	matrix metallopeptidase 9	Homo sapiens	26-30
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	40-43
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	AKT serine/threonine kinase 1	Homo sapiens	44-47
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	40-43
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	mitogen-activated protein kinase kinase 7	Homo sapiens	65-68
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	mitogen-activated protein kinase 3	Homo sapiens	69-75
25539072-7	2015	DISCUSSION: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways.	fangchinoline	12-25	protein tyrosine kinase 2	Homo sapiens	131-134
25539072-8	2015	CONCLUSION: Fangchinoline could inhibit the phosphorylation of FAK(p-Tyr397), at least partially.	fangchinoline	12-25	protein tyrosine kinase 2	Homo sapiens	63-66
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	44-47
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66
25559449-6	2014	The IC50 values of celecoxib, rofecoxib, sinomenine, bulleyaconitine A, tetrandrine, fangchinoline, berberine hydrochloride and sophocarpidine towards COX-2 were determined.	fangchinoline	85-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25872479-0	2015	Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	47-50
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	AKT serine/threonine kinase 1	Homo sapiens	11-14
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	matrix metallopeptidase 2	Homo sapiens	15-19
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	matrix metallopeptidase 9	Homo sapiens	20-24
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	AKT serine/threonine kinase 1	Homo sapiens	34-37
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	AKT serine/threonine kinase 1	Homo sapiens	34-37
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	glycogen synthase kinase 3 beta	Homo sapiens	59-67
25872479-4	2015	All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3beta/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K.	fangchinoline	103-116	cyclin dependent kinase 2	Homo sapiens	68-72
24856768-3	2014	Furthermore, tetrandrine and fangchinoline increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrate rhodamine 123 (Rho123) and inhibited its efflux in Caco-2 and CEM/ADR5000 cells.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
24856768-4	2014	In addition, tetrandrine and fangchinoline significantly reduced P-gp expression in a concentration-dependent manner.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
24856768-5	2014	These results suggest that tetrandrine and fangchinoline can reverse MDR by increasing the intracellular concentration of anticancer drugs, and thus they could serve as a lead for developing new drugs to overcome P-gp mediated drug resistance in clinic cancer therapy.	fangchinoline	43-56	ATP binding cassette subfamily B member 1	Homo sapiens	213-217
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin D1	Homo sapiens	123-132
24568493-0	2014	Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells.	fangchinoline	0-13	AKT serine/threonine kinase 1	Homo sapiens	46-49
24568493-0	2014	Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells.	fangchinoline	0-13	glycogen synthase kinase 3 beta	Homo sapiens	50-59
24568493-0	2014	Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells.	fangchinoline	0-13	cyclin D1	Homo sapiens	61-70
24856768-0	2014	Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells.	fangchinoline	16-29	ATP binding cassette subfamily B member 1	Homo sapiens	135-149
24856768-3	2014	Furthermore, tetrandrine and fangchinoline increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrate rhodamine 123 (Rho123) and inhibited its efflux in Caco-2 and CEM/ADR5000 cells.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	103-117
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin D3	Homo sapiens	134-143
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin dependent kinase inhibitor 1A	Homo sapiens	233-236
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin dependent kinase inhibitor 1A	Homo sapiens	237-241
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	dynactin subunit 6	Homo sapiens	247-250
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin dependent kinase inhibitor 1B	Homo sapiens	251-255
23401195-6	2013	Moreover, Fangchinoline also inhibited the kinase activities of CDK2, CDK4, and CDK6.	fangchinoline	10-23	cyclin dependent kinase 2	Homo sapiens	64-68
23401195-6	2013	Moreover, Fangchinoline also inhibited the kinase activities of CDK2, CDK4, and CDK6.	fangchinoline	10-23	cyclin dependent kinase 4	Homo sapiens	70-74
23401195-6	2013	Moreover, Fangchinoline also inhibited the kinase activities of CDK2, CDK4, and CDK6.	fangchinoline	10-23	cyclin dependent kinase 6	Homo sapiens	80-84
23596478-0	2013	Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells.	fangchinoline	0-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	67-73
23596478-0	2013	Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells.	fangchinoline	0-13	cyclin D2	Homo sapiens	78-83
23596478-7	2013	Additional experiments revealed that fangchinoline induces cell cycle arrest at the G0/G1 phase and has no effect on apoptosis, which is mediated through the upregulation of cyclin-dependent kinase (CDK)-N1A and MCL-1 mRNA levels, as well as the downregulation of cyclin D2 (CCND2) mRNA levels.	fangchinoline	37-50	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	212-217
23596478-7	2013	Additional experiments revealed that fangchinoline induces cell cycle arrest at the G0/G1 phase and has no effect on apoptosis, which is mediated through the upregulation of cyclin-dependent kinase (CDK)-N1A and MCL-1 mRNA levels, as well as the downregulation of cyclin D2 (CCND2) mRNA levels.	fangchinoline	37-50	cyclin D2	Homo sapiens	264-273
23596478-7	2013	Additional experiments revealed that fangchinoline induces cell cycle arrest at the G0/G1 phase and has no effect on apoptosis, which is mediated through the upregulation of cyclin-dependent kinase (CDK)-N1A and MCL-1 mRNA levels, as well as the downregulation of cyclin D2 (CCND2) mRNA levels.	fangchinoline	37-50	cyclin D2	Homo sapiens	275-280
22720080-0	2012	Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing.	fangchinoline	0-13	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	91-96
22720080-7	2012	Western blot analysis of HIV envelope proteins expressed in transfected 293T cells and in isolated virions showed that fangchinoline inhibited HIV-1 gp160 processing, resulting in reduced envelope glycoprotein incorporation into nascent virions.	fangchinoline	119-132	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	149-154
22720080-8	2012	Collectively, our results demonstrate that fangchinoline inhibits HIV-1 replication by interfering with gp160 proteolytic processing.	fangchinoline	43-56	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	104-109
20822025-3	2010	Verapamil hydrochloride was adopted as the active control to investigate the bilateral transport activity of paclitaxel regulated by fangchinoline in MDR1-MDCK II cells.	fangchinoline	133-146	ATP binding cassette subfamily B member 1	Homo sapiens	150-154
21418191-0	2011	Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.	fangchinoline	0-13	tumor protein p53	Homo sapiens	48-51
21418191-0	2011	Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.	fangchinoline	0-13	sestrin 2	Homo sapiens	52-60
21418191-0	2011	Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.	fangchinoline	0-13	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	61-65
21418191-2	2011	Here we have investigated the mode of cell death induced by fangchinoline and its underlying mechanism in two human hepatocellular carcinoma cell lines, HepG2 and PLC/PRF/5.	fangchinoline	60-73	heparan sulfate proteoglycan 2	Homo sapiens	163-166
21418191-6	2011	Nuclear translocation of p53 was involved in induction of autophagy by fangchinoline, followed by selective transactivation of the autophagy-related gene sestrin2 and initiation of the autophagic process.	fangchinoline	71-84	tumor protein p53	Homo sapiens	25-28
21418191-8	2011	siRNA for Atg 5 or pharmacological block of p53 abolished fangchinoline-induced autophagy and inhibition of autophagy switched cell death to apoptosis in these cells, suggesting that cell death is irreversible once autophagy is induced by fangchinoline.	fangchinoline	58-71	autophagy related 5	Homo sapiens	10-15
21418191-8	2011	siRNA for Atg 5 or pharmacological block of p53 abolished fangchinoline-induced autophagy and inhibition of autophagy switched cell death to apoptosis in these cells, suggesting that cell death is irreversible once autophagy is induced by fangchinoline.	fangchinoline	58-71	tumor protein p53	Homo sapiens	44-47
22130369-6	2011	Fangchinoline induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspases-3, -8, and -9, and cleavage of poly(ADP ribose) polymerase, as well as enhanced mitochondrial cytochrome c release.	fangchinoline	0-13	caspase 3	Homo sapiens	96-118
22130369-6	2011	Fangchinoline induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspases-3, -8, and -9, and cleavage of poly(ADP ribose) polymerase, as well as enhanced mitochondrial cytochrome c release.	fangchinoline	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	136-163
22130369-6	2011	Fangchinoline induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspases-3, -8, and -9, and cleavage of poly(ADP ribose) polymerase, as well as enhanced mitochondrial cytochrome c release.	fangchinoline	0-13	cytochrome c, somatic	Homo sapiens	199-211
22130369-7	2011	Furthermore, fangchinoline increased the expression of the proapoptotic protein B cell lymphoma-2 associated X (Bax) and decreased the expression of the antiapoptotic protein B cell lymphoma-2 (Bcl-2).	fangchinoline	13-26	BCL2 apoptosis regulator	Homo sapiens	80-97
22130369-7	2011	Furthermore, fangchinoline increased the expression of the proapoptotic protein B cell lymphoma-2 associated X (Bax) and decreased the expression of the antiapoptotic protein B cell lymphoma-2 (Bcl-2).	fangchinoline	13-26	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
22130369-7	2011	Furthermore, fangchinoline increased the expression of the proapoptotic protein B cell lymphoma-2 associated X (Bax) and decreased the expression of the antiapoptotic protein B cell lymphoma-2 (Bcl-2).	fangchinoline	13-26	BCL2 apoptosis regulator	Homo sapiens	175-192
22130369-7	2011	Furthermore, fangchinoline increased the expression of the proapoptotic protein B cell lymphoma-2 associated X (Bax) and decreased the expression of the antiapoptotic protein B cell lymphoma-2 (Bcl-2).	fangchinoline	13-26	BCL2 apoptosis regulator	Homo sapiens	194-199
22130369-8	2011	In addition, the proliferation-inhibitory effect of fangchinoline was associated with decreased levels of phosphorylated Akt.	fangchinoline	52-65	AKT serine/threonine kinase 1	Homo sapiens	121-124
22130369-9	2011	Our results indicate that fangchinoline can inhibit breast cancer cell proliferation by inducing apoptosis via the mitochondrial apoptotic pathway and decreasing phosphorylated Akt.	fangchinoline	26-39	AKT serine/threonine kinase 1	Homo sapiens	177-180
20822025-0	2010	[Transmembrane transport activity of paclitaxel regulated by fangchinoline in MDR1-mDCK II cells].	fangchinoline	61-74	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
20822025-1	2010	OBJECTIVE: To research the regulation of transmembrane transport activity of paclitaxel influenced by fangchinoline in MDR1-MDCK II cells.	fangchinoline	102-115	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
20822025-8	2010	CONCLUSION: Fangchinoline can apparently decrease the efflux of paclitaxel and inhibit the multidrug resistance of antitumor drug mediated by P-gp.	fangchinoline	12-25	phosphoglycolate phosphatase	Homo sapiens	142-146
20208355-0	2010	Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.	fangchinoline	0-13	interferon alpha inducible protein 27	Homo sapiens	62-65
20208355-0	2010	Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.	fangchinoline	0-13	proliferating cell nuclear antigen	Homo sapiens	67-71
20208355-0	2010	Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft.	fangchinoline	0-13	proliferating cell nuclear antigen	Homo sapiens	77-83