PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18853423-6	2008	alpha-Aminoadipic acid (a specific astroglial toxin) infusion into the entorhinal cortex induced astroglial damage and changed the electrophysiological properties in the CA1 region.	2-Aminoadipic Acid	0-22	carbonic anhydrase 1	Rattus norvegicus	170-173
20722971-9	2010	Furthermore, L-alpha-aminoadipate, the glial inhibitor fluorocitrate, and a peptide inhibitor of c-Jun N-terminal Kinase all reduced light touch-evoked ERK activation ipsilateral to touch.	2-Aminoadipic Acid	13-33	mitogen-activated protein kinase 1	Homo sapiens	152-155
20815929-7	2010	Phosphorylated NR1 (pNR1) or glial fibrillary acidic protein (GFAP) expression was down-regulated by intrathecal ketamine (100, 1000 mug/kg) or LAA (50, 100 nmol) respectively.	2-Aminoadipic Acid	144-147	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	15-18
20815929-7	2010	Phosphorylated NR1 (pNR1) or glial fibrillary acidic protein (GFAP) expression was down-regulated by intrathecal ketamine (100, 1000 mug/kg) or LAA (50, 100 nmol) respectively.	2-Aminoadipic Acid	144-147	glial fibrillary acidic protein	Homo sapiens	29-60
20815929-7	2010	Phosphorylated NR1 (pNR1) or glial fibrillary acidic protein (GFAP) expression was down-regulated by intrathecal ketamine (100, 1000 mug/kg) or LAA (50, 100 nmol) respectively.	2-Aminoadipic Acid	144-147	glial fibrillary acidic protein	Homo sapiens	62-66
19187440-3	2009	iNOS expression was attenuated by the MAPK/extracellular signal-regulated kinase pathway inhibitor U0126 and the phosphorylated forms of extracellular signal-regulated kinase 1 and 2 were detectable in microglia treated with albumin or fraction V. Glutamate release was prevented by l-alpha-aminoadipate and glutathione levels in microglia rose on exposure to albumin.	2-Aminoadipic Acid	283-303	nitric oxide synthase 2	Rattus norvegicus	0-4
19187440-3	2009	iNOS expression was attenuated by the MAPK/extracellular signal-regulated kinase pathway inhibitor U0126 and the phosphorylated forms of extracellular signal-regulated kinase 1 and 2 were detectable in microglia treated with albumin or fraction V. Glutamate release was prevented by l-alpha-aminoadipate and glutathione levels in microglia rose on exposure to albumin.	2-Aminoadipic Acid	283-303	mitogen activated protein kinase 3	Rattus norvegicus	137-182
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	160-178	aminoadipate aminotransferase	Homo sapiens	0-35
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	160-178	aminoadipate aminotransferase	Homo sapiens	37-43
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	160-178	aminoadipate aminotransferase	Homo sapiens	69-99
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	160-178	aminoadipate aminotransferase	Homo sapiens	101-107
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	214-232	aminoadipate aminotransferase	Homo sapiens	0-35
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	214-232	aminoadipate aminotransferase	Homo sapiens	37-43
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	214-232	aminoadipate aminotransferase	Homo sapiens	69-99
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	2-Aminoadipic Acid	214-232	aminoadipate aminotransferase	Homo sapiens	101-107
17116397-1	2007	Homoisocitrate dehydrogenase is involved in the alpha-aminoadipate pathway of biosynthesis of l-lysine in fungi, yeast, some prokaryotic bacteria, and archaea.	2-Aminoadipic Acid	48-66	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
18086528-0	2008	Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway.	2-Aminoadipic Acid	94-112	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	49-77
18086528-1	2008	Homoisocitrate dehydrogenase is involved in the alpha-aminoadipate pathway of L-lysine biosynthesis in higher fungi such as yeast and human pathogenic fungi.	2-Aminoadipic Acid	48-66	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
17442055-4	2007	The novel KAT had a pH optimum of 8.0 and a low capacity to transaminate glutamine or alpha-aminoadipate (the classic substrates of KAT I and KAT II, respectively).	2-Aminoadipic Acid	86-104	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	10-13
17442055-4	2007	The novel KAT had a pH optimum of 8.0 and a low capacity to transaminate glutamine or alpha-aminoadipate (the classic substrates of KAT I and KAT II, respectively).	2-Aminoadipic Acid	86-104	kynurenine aminotransferase 1	Homo sapiens	132-148
17881610-9	2007	NFATc3 nuclear accumulation in pericytes was prevented when astrocytic function was abolished with the gliotoxin L-alpha-aminoadipate or by the inhibition of calcineurin, cyclooxygenase, and nitric oxide synthase.	2-Aminoadipic Acid	113-133	nuclear factor of activated T-cells 3	Rattus norvegicus	0-6
16091367-12	2005	Specifically, we detected apoAI tryptophan oxidation to mono- and dihydroxytryptophan and apoAI lysine modification to chlorolysine and 2-aminoadipic acid.	2-Aminoadipic Acid	136-154	apolipoprotein A1	Homo sapiens	26-31
17023168-5	2006	The LKR/SDH activity produces alpha-aminoadipate semialdehyde which could be further converted into alpha-aminoadipate and acetyl CoA.	2-Aminoadipic Acid	30-48	alpha-aminoadipic semialdehyde synthase	Brassica napus	4-7
17023168-5	2006	The LKR/SDH activity produces alpha-aminoadipate semialdehyde which could be further converted into alpha-aminoadipate and acetyl CoA.	2-Aminoadipic Acid	30-48	alpha-aminoadipic semialdehyde synthase	Brassica napus	8-11
16091367-12	2005	Specifically, we detected apoAI tryptophan oxidation to mono- and dihydroxytryptophan and apoAI lysine modification to chlorolysine and 2-aminoadipic acid.	2-Aminoadipic Acid	136-154	apolipoprotein A1	Homo sapiens	90-95
18634602-4	2004	Pigment epithelium-derived factor is able to support proper membrane folding after inhibition of Muller cell metabolism by alpha-aminoadipic acid, while isopropyl beta-D-thiogalactoside, a permissive glycan, requires intact Muller cell function.	2-Aminoadipic Acid	123-145	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog	Xenopus laevis	0-33
12632405-7	2003	Relative specificity of immobilized VHb-DAO on D-alpha-aminoadipic acid, a precursor in cephalosporin C biosynthesis, increased twofold, compared with that of immobilized DAO, suggesting that conformational modification of the VHb-DAO fusion protein may be altered in favor of cephalosporin C.	2-Aminoadipic Acid	47-71	D-amino acid oxidase	Homo sapiens	40-43
14587101-6	2003	Therefore, the positive selection procedure for the isolation of lys2 mutants on alpha-aminoadipate, as practised in S. cerevisiae, cannot be applied to K. lactis.	2-Aminoadipic Acid	81-99	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	65-69
12824766-3	2003	An intravitreal injection of 2.5 microM L-alpha-aminoadipic acid inhibited the ERG ON response and inhibited refractive compensation to negative lens defocus, but not to positive or zero power lens defocus.	2-Aminoadipic Acid	40-64	ETS transcription factor ERG	Homo sapiens	79-82
12126930-1	2002	In mammals, the conversion of alpha-aminoadipate to alpha-ketoadipate by alpha-aminoadipate aminotransferase (AADAT) is an intermediate step in lysine degradation.	2-Aminoadipic Acid	30-48	aminoadipate aminotransferase	Homo sapiens	73-108
12756539-4	2003	Sequence alignments indicate the presence of all functional domains required for the activation, adenylation, dehydrogenation and alpha-aminoadipic acid binding in the Lys2p.	2-Aminoadipic Acid	130-152	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	168-173
12126930-1	2002	In mammals, the conversion of alpha-aminoadipate to alpha-ketoadipate by alpha-aminoadipate aminotransferase (AADAT) is an intermediate step in lysine degradation.	2-Aminoadipic Acid	30-48	aminoadipate aminotransferase	Homo sapiens	110-115
10998364-8	2000	Our results suggest that the uni-directional activity of LKR plays an important role in regulating the catabolic function of the alpha-amino adipic acid pathway in plants.	2-Aminoadipic Acid	129-152	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	57-60
11907033-8	2002	Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 did not accept cystine, homocysteate, and l-alpha-aminoadipate and exhibited high affinity to aspartate as well as glutamate, suggesting that the negative charge recognition site in the side chain-binding site of AGT1 would be closer to the alpha-carbon binding site compared with that of xCT.	2-Aminoadipic Acid	147-167	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	100-104
11907033-8	2002	Distinct from the Na(+)-independent cystine/glutamate transporter xCT structurally related to AGT1, AGT1 did not accept cystine, homocysteate, and l-alpha-aminoadipate and exhibited high affinity to aspartate as well as glutamate, suggesting that the negative charge recognition site in the side chain-binding site of AGT1 would be closer to the alpha-carbon binding site compared with that of xCT.	2-Aminoadipic Acid	147-167	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	Mus musculus	100-104
11286508-1	2001	In mammals, L-lysine is first catabolized to alpha-aminoadipate semialdehyde by the bifunctional enzyme alpha-aminoadipate semialdehyde synthase (AASS), followed by a conversion to alpha-aminoadipate by alpha-aminoadipate semialdehyde dehydrogenase.	2-Aminoadipic Acid	45-63	aminoadipate-semialdehyde synthase	Homo sapiens	104-144
11083877-10	2001	Adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate were also transported by the human ODC.	2-Aminoadipic Acid	69-83	solute carrier family 25 member 21	Homo sapiens	146-149
11008218-12	2000	The steady-state level of opsin in retinas exposed to alpha-aminoadipic acid was unchanged compared with control eyes, whereas, in eyes exposed to fluorocitrate, opsin levels were slightly reduced.	2-Aminoadipic Acid	54-76	rhodopsin, gene2 L homeolog	Xenopus laevis	26-31
10544028-6	1999	Using SPR binding assays, a submicromolar inhibitor (IC(50) = 0.70 microM) was obtained when Glu(1) was replaced with alpha-aminoadipate and Tyr(3) was replaced with 4-carboxymethyl-Phe, providing peptide 14, G1TE(Adi(1), cmPhe(3)).	2-Aminoadipic Acid	118-136	sepiapterin reductase	Homo sapiens	6-9
10517698-0	1999	Expression of beta-amyloid precursor and Bcl-2 proto-oncogene proteins in rat retinas after intravitreal injection of aminoadipic acid.	2-Aminoadipic Acid	118-134	BCL2, apoptosis regulator	Rattus norvegicus	41-46
9242889-13	1997	When the glia cell-specific toxin alpha-aminoadipic acid (alpha AAA) was applied, the pattern of vimentin-positive Muller cells became irregular, or even locally missing.	2-Aminoadipic Acid	34-56	vimentin	Oryctolagus cuniculus	97-105
10320345-1	1999	A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5.	2-Aminoadipic Acid	68-86	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	170-174
10320345-1	1999	A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5.	2-Aminoadipic Acid	68-86	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	179-183
10215921-6	1999	After alpha-aminoadipate, loss of astrocytes in the dentate gyrus was demonstrated by loss of staining for GFAP.	2-Aminoadipic Acid	6-24	glial fibrillary acidic protein	Rattus norvegicus	107-111
10022564-9	1999	This is consistent with the fact that the BMP-2 effect on dopaminergic neurons was observed even when the cultures were treated with alpha-aminoadipic acid to exclude the presence of glial cells.	2-Aminoadipic Acid	133-155	bone morphogenetic protein 2	Homo sapiens	42-47
9283824-10	1997	Suppression of cell proliferation and subsequent maturation of GFAP-positive cells by 5-fluorodeoxyuridine or aminoadipic acid abolished the neuron survival-promoting effect of BMP 2.	2-Aminoadipic Acid	110-126	glial fibrillary acidic protein	Rattus norvegicus	63-67
9283824-10	1997	Suppression of cell proliferation and subsequent maturation of GFAP-positive cells by 5-fluorodeoxyuridine or aminoadipic acid abolished the neuron survival-promoting effect of BMP 2.	2-Aminoadipic Acid	110-126	bone morphogenetic protein 2	Rattus norvegicus	177-182
8896828-8	1996	We now report that L-alpha-aminoadipate also blocks or reverses the persistent depolarization of quisqualate-sensitized neurons which is induced by exposure to the hydroxamates or L-AP3.	2-Aminoadipic Acid	19-39	leucine aminopeptidase 3	Rattus norvegicus	180-185
9058424-0	1997	Induction of glutamine synthetase by L-alpha-aminoadipate in developmental stages of cultured astrocytes.	2-Aminoadipic Acid	37-57	glutamate-ammonia ligase	Rattus norvegicus	13-33
8764822-2	1996	A significant increase in alpha-aminoadipic acid (AAA) occurred in plasma and urine of VGB-treated children, thus mimicking a known rare metabolic disease, alpha-aminoadipic aciduria (AAAuria).	2-Aminoadipic Acid	26-48	amyloid beta precursor protein	Homo sapiens	50-53
7834205-7	1994	L-alpha Aminoadipate was a competitive inhibitor of both glutamine synthetase, and gamma-glutamylcysteine synthetase, with Ki values of 209 microM and 7 mM respectively.	2-Aminoadipic Acid	0-20	glutamate-ammonia ligase	Rattus norvegicus	57-77
8847551-5	1995	injections of DL-alpha-aminoadipic acid (DLaAA), which exerts specific gliotoxicity through glutamine synthetase (GS) inhibition, and of 3-mercaptoproprionic acid (3MP), a potent inhibitor of glutamic acid decarboxylase (GAD: the rate-limiting enzyme in the biosynthesis of gamma-aminobutyric acid [GABA]), were also examined.	2-Aminoadipic Acid	14-39	glutamate-ammonia ligase	Rattus norvegicus	92-112
8847551-5	1995	injections of DL-alpha-aminoadipic acid (DLaAA), which exerts specific gliotoxicity through glutamine synthetase (GS) inhibition, and of 3-mercaptoproprionic acid (3MP), a potent inhibitor of glutamic acid decarboxylase (GAD: the rate-limiting enzyme in the biosynthesis of gamma-aminobutyric acid [GABA]), were also examined.	2-Aminoadipic Acid	41-46	glutamate-ammonia ligase	Rattus norvegicus	92-112
8563976-8	1995	After selective damage of Muller cells by the gliotoxin DL-alpha-aminoadipic acid, the columnar organization is destabilized, as evidenced by a decrease in vimentin expression and by the migration of individual neurons out of their cell column.	2-Aminoadipic Acid	56-81	vimentin	Gallus gallus	156-164
7500375-5	1995	However, the elimination of astroglia in our cultures by alpha-aminoadipic acid treatment blocks EGF"s effects on the cholinergic neurons.	2-Aminoadipic Acid	57-79	epidermal growth factor	Rattus norvegicus	97-100
7834205-7	1994	L-alpha Aminoadipate was a competitive inhibitor of both glutamine synthetase, and gamma-glutamylcysteine synthetase, with Ki values of 209 microM and 7 mM respectively.	2-Aminoadipic Acid	0-20	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	83-116
1473456-1	1992	The ability of the gliotoxic compounds D,L-, D- or L-2-aminoadipic acid (AAA) to increase selectively the intracellular concentration of free calcium ion ([Ca2+]i) was examined in Muller cells cultured with or without retinal neurons.	2-Aminoadipic Acid	73-76	immunoglobulin kappa variable 3-15	Homo sapiens	51-54
7509049-5	1993	Tonic channel activity was enhanced by the glutamate uptake inhibitor L-alpha-aminoadipate (L-alpha-AA), the degree of enhancement being greater in the EGL than the GCL.	2-Aminoadipic Acid	70-90	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	165-168
7509049-5	1993	Tonic channel activity was enhanced by the glutamate uptake inhibitor L-alpha-aminoadipate (L-alpha-AA), the degree of enhancement being greater in the EGL than the GCL.	2-Aminoadipic Acid	92-102	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	165-168
7953634-10	1994	As with AP4 and AP5, sensitization to L-AP6 was reversed by L-alpha-aminoadipate.	2-Aminoadipic Acid	60-80	replication initiator 1	Rattus norvegicus	8-11
1973584-1	1990	DL-alpha-aminoadipic acid (DL-alpha AA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA) level in the hypothalamus of rats 2 and 4 h after single intracerebroventricular (i.c.v.)	2-Aminoadipic Acid	0-25	histamine N-methyltransferase	Rattus norvegicus	104-134
2055241-2	1991	This sensitization to L-AP4 is known to be blocked by simultaneous exposure to L-homocysteinesulfinic acid, L-alpha-aminoadipic acid and L-serine-O-sulfate during exposure to quisqualate.	2-Aminoadipic Acid	108-132	transcription factor AP-4	Homo sapiens	24-27
1707214-7	1990	The new vessels in the vitreous of rabbits were seen in 9 out of 10 eyes when b-FGF was implanted in the vitreous with an intravitreal injection of amino adipic acid solution (1 mg in 0.2 ml of physical saline), although none of the 8 eyes formed new vessels when sodium iodate was injected intravenously after implantation of b-FGF with aminoadipic acid.	2-Aminoadipic Acid	148-165	fibroblast growth factor 2	Cavia porcellus	78-83
1707214-7	1990	The new vessels in the vitreous of rabbits were seen in 9 out of 10 eyes when b-FGF was implanted in the vitreous with an intravitreal injection of amino adipic acid solution (1 mg in 0.2 ml of physical saline), although none of the 8 eyes formed new vessels when sodium iodate was injected intravenously after implantation of b-FGF with aminoadipic acid.	2-Aminoadipic Acid	338-354	fibroblast growth factor 2	Cavia porcellus	78-83
2340290-5	1990	The pit fall of an indirect assay of L-pipecolate oxidase by means of the assay of alpha-aminoadipic acid formation was discussed.	2-Aminoadipic Acid	83-105	pipecolic acid and sarcosine oxidase	Homo sapiens	37-57
1973584-1	1990	DL-alpha-aminoadipic acid (DL-alpha AA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA) level in the hypothalamus of rats 2 and 4 h after single intracerebroventricular (i.c.v.)	2-Aminoadipic Acid	0-25	histamine N-methyltransferase	Rattus norvegicus	136-140
1973584-1	1990	DL-alpha-aminoadipic acid (DL-alpha AA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA) level in the hypothalamus of rats 2 and 4 h after single intracerebroventricular (i.c.v.)	2-Aminoadipic Acid	0-25	monoamine oxidase B	Rattus norvegicus	146-165
1973584-1	1990	DL-alpha-aminoadipic acid (DL-alpha AA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA) level in the hypothalamus of rats 2 and 4 h after single intracerebroventricular (i.c.v.)	2-Aminoadipic Acid	0-25	monoamine oxidase B	Rattus norvegicus	167-172
35621206-1	2022	Background Elevated plasma levels of alpha-aminoadipic acid (2-AAA) have been associated with the development of type 2 diabetes and atherosclerosis.	2-Aminoadipic Acid	37-59	AAA1	Homo sapiens	63-66
1970137-1	1990	Intrastriatal injection of the excitatory amino acid analogue DL-alpha-aminoadipate (100 micrograms in 2 microliters saline, pH 7.4) into anesthetized rats caused a significant reduction in striatal glutamine synthetase activity in the ipsilateral compared to the contralateral striatum 6 h after the injection.	2-Aminoadipic Acid	62-83	glutamate-ammonia ligase	Rattus norvegicus	199-219
33802856-0	2021	Allysine and alpha-Aminoadipic Acid as Markers of the Glyco-Oxidative Damage to Human Serum Albumin under Pathological Glucose Concentrations.	2-Aminoadipic Acid	13-35	albumin	Homo sapiens	92-99
35157758-8	2022	Among the IDH-mutated subtypes, we observed high levels of amino acids, especially glycine and 2-aminoadipic acid, in grade 4 glioma, and N-acetyl aspartic acid in low-grade astrocytoma and oligodendroglioma.	2-Aminoadipic Acid	95-113	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	10-13
3859458-4	1985	The ability to utilize alpha-aminoadipate was used for lys2 mutant screening.	2-Aminoadipic Acid	23-41	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	55-59
2696980-8	1989	The injection of D-alpha-aminoadipic acid into the SI/LPO produced a significant inhibition of the hypermotility response produced by N-methyl-D-aspartic acid at a dose that did not produce a significant inhibition of the hypermotility response produced by AMPA.	2-Aminoadipic Acid	17-41	lactoperoxidase	Homo sapiens	54-57
2542463-6	1989	When these compounds were examined for their ability to inhibit [3H]NAAG binding to membranes of rat forebrain, the relative order of potency was L-alpha-aminoadipate = D-alpha-aminoadipate greater than L-AP4 greater than L-serine-O-phosphate greater than D-AP4 much greater than D,L-AP3.	2-Aminoadipic Acid	146-166	replication initiator 1	Rattus norvegicus	258-261
3921525-1	1985	In contrast to wild-type strains of the yeast Saccharomyces cerevisiae, lys2 and lys5 mutants are able to utilize alpha-aminoadipate as a primary source of nitrogen.	2-Aminoadipic Acid	114-132	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	72-76
3921525-1	1985	In contrast to wild-type strains of the yeast Saccharomyces cerevisiae, lys2 and lys5 mutants are able to utilize alpha-aminoadipate as a primary source of nitrogen.	2-Aminoadipic Acid	114-132	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	81-85
3921525-6	1985	Our results demonstrate that the anabolism of high levels of alpha-aminoadipate through the biosynthetic pathway of lysine results in the accumulation of a toxic intermediate and, furthermore, that lys2 and lys5 mutants contain blocks leading to the formation of this intermediate.	2-Aminoadipic Acid	61-79	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	198-202
3921525-6	1985	Our results demonstrate that the anabolism of high levels of alpha-aminoadipate through the biosynthetic pathway of lysine results in the accumulation of a toxic intermediate and, furthermore, that lys2 and lys5 mutants contain blocks leading to the formation of this intermediate.	2-Aminoadipic Acid	61-79	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	207-211
2542463-5	1989	The L-isomers of serine-O-phosphate and alpha-aminoadipate were selective inhibitors of IBO-stimulated phosphoinositide hydrolysis, but were less potent than L-AP4 or D,L-AP3.	2-Aminoadipic Acid	40-58	replication initiator 1	Rattus norvegicus	160-163
3023949-7	1986	Because all fungi synthesize lysine via the alpha-aminoadipate pathway, the techniques developed here for using the S. cerevisiae LYS2 gene should be directly applicable to other fungal systems.	2-Aminoadipic Acid	44-62	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	130-134
6752121-5	1982	Glutamate:keto-adipate transaminase levels were derepressed two- to fivefold in lys2 mutants using alpha-aminoadipate as a nitrogen source.	2-Aminoadipic Acid	99-117	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	80-84
6143333-1	1984	The effect of kainic acid and related compounds, gamma-D-glutamylglycine, cis-2,3-piperidine dicarboxylic acid and DL alpha-aminoadipic acid, was investigated on purified and membrane bound gamma-glutamyl transpeptidase [GGT].	2-Aminoadipic Acid	115-140	inactive glutathione hydrolase 2	Homo sapiens	190-219
6752121-3	1982	Mutants belonging to the lys2 and lys14 loci were able to grow in lysine-supplemented alpha-aminoadipate medium, although not as well as when selected amino acids were added.	2-Aminoadipic Acid	86-104	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	25-29
574371-0	1979	Isolation and nature of intracellular alpha-aminoadipic acid-containing peptides from Paecilomyces persicinus P-10.	2-Aminoadipic Acid	38-60	S100 calcium binding protein A10	Homo sapiens	110-114
6110468-0	1981	Induction of glutamine synthetase in embryonic neural retina: its suppression by the gliatoxic agent alpha-aminoadipic acid.	2-Aminoadipic Acid	101-123	glutamate-ammonia ligase	Gallus gallus	13-33
6133238-1	1980	D- and L-5-aminohex-2-enedioic acid (AHED) and the DL-2-bromo derivative, which are conformationally restricted analogues of the excitatory amino acid antagonist D-alpha-aminoadipic acid (D alpha AA), were tested microelectrophoretically on cat spinal neurones.	2-Aminoadipic Acid	162-186	ribosomal protein L5	Homo sapiens	7-10
5972332-0	1966	Acitivity of glutamine synthetase toward the optical isomers of alpha-aminoadipic acid.	2-Aminoadipic Acid	64-86	glutamate-ammonia ligase	Homo sapiens	13-33
17248969-0	1979	Selection of lys2 Mutants of the Yeast SACCHAROMYCES CEREVISIAE by the Utilization of alpha-AMINOADIPATE.	2-Aminoadipic Acid	86-104	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	13-17
17248969-2	1979	However, alpha-aminoadipate is utilized as a nitrogen source by lys2 and lys5 strains having complete or partial deficiencies of alpha-aminoadipate reductase and, to a limited extent, by heterozygous lys2/+ strains.	2-Aminoadipic Acid	9-27	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	64-68
17248969-2	1979	However, alpha-aminoadipate is utilized as a nitrogen source by lys2 and lys5 strains having complete or partial deficiencies of alpha-aminoadipate reductase and, to a limited extent, by heterozygous lys2/+ strains.	2-Aminoadipic Acid	9-27	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	73-77
17248969-2	1979	However, alpha-aminoadipate is utilized as a nitrogen source by lys2 and lys5 strains having complete or partial deficiencies of alpha-aminoadipate reductase and, to a limited extent, by heterozygous lys2/+ strains.	2-Aminoadipic Acid	9-27	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	200-204
17248969-3	1979	Lys2 mutants were conveniently selected on media containing alpha-aminoadipate as a nitrogen source, lysine, and other supplements to furnish other possible auxotrophic requirements.	2-Aminoadipic Acid	60-78	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	0-4
17248969-5	1979	In addition to the predominant class of lys2 mutants, low frequencies of lys5 mutants and mutants not having any obvious lysine requirement were recovered on alpha-aminoadipate medium.	2-Aminoadipic Acid	158-176	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	73-77
336041-0	1977	Isolation of alpha-amino adipic acid from mature dermal collagen and elastin.	2-Aminoadipic Acid	13-36	elastin	Homo sapiens	69-76
31541119-0	2019	2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity.	2-Aminoadipic Acid	0-18	insulin	Homo sapiens	56-63
32738373-6	2020	Stimulation of cells with cholecystokinin in the absence of Ca2+ in the extracellular medium abolished further mobilization of Ca2+ by alpha-aminoadipic acid.	2-Aminoadipic Acid	135-157	cholecystokinin	Mus musculus	26-41
31513788-5	2019	Pretreatment with astrocytes toxin, L-alpha-aminoadipate (L-AAA) reduced anxiety-like behaviors and the GFAP expression in the PVN.	2-Aminoadipic Acid	36-56	glial fibrillary acidic protein	Homo sapiens	104-108
32200226-11	2020	In addition, plasma alpha-amino adipic acid levels were elevated in both untreated and IGF-I-treated patients.	2-Aminoadipic Acid	20-43	insulin like growth factor 1	Homo sapiens	87-92
32157124-8	2020	Aminoadipic acid was found to be significantly correlated with CRP levels and 2-Hydroxy-3-methylbutyric acid and Palmitoleic acid with PCT levels.	2-Aminoadipic Acid	0-16	C-reactive protein	Homo sapiens	63-66
31239324-8	2019	When ESCs were induced to undergo ectodermal differentiation, the abundance of kynurenine in the medium was reduced through activation of the main kynurenine catabolic pathway mediated by kynurenine aminotransferase 2 (KAT2, also known as AADAT), resulting in the secretion of 2-aminoadipic acid (2-AAA) into the culture medium.	2-Aminoadipic Acid	277-295	aminoadipate aminotransferase	Homo sapiens	188-217
31239324-8	2019	When ESCs were induced to undergo ectodermal differentiation, the abundance of kynurenine in the medium was reduced through activation of the main kynurenine catabolic pathway mediated by kynurenine aminotransferase 2 (KAT2, also known as AADAT), resulting in the secretion of 2-aminoadipic acid (2-AAA) into the culture medium.	2-Aminoadipic Acid	277-295	aminoadipate aminotransferase	Homo sapiens	219-223
31239324-8	2019	When ESCs were induced to undergo ectodermal differentiation, the abundance of kynurenine in the medium was reduced through activation of the main kynurenine catabolic pathway mediated by kynurenine aminotransferase 2 (KAT2, also known as AADAT), resulting in the secretion of 2-aminoadipic acid (2-AAA) into the culture medium.	2-Aminoadipic Acid	277-295	aminoadipate aminotransferase	Homo sapiens	239-244
31056353-6	2019	A similar effect was seen in Rgr+/+ retinas following treatment with the glial cell toxin, alpha-aminoadipic acid.	2-Aminoadipic Acid	91-113	retinal G protein coupled receptor	Mus musculus	29-32
30592974-9	2019	However, AG490 or astrocytic inhibition (by GFAP antisense oligonucleotide and alpha-aminoadipate) significantly increased Iba-1-labeled microglial activity and M1 phenotype microglial mRNA levels, reflecting that proinflammatory potentials were mediated by AG490 or astrocytic inhibition.	2-Aminoadipic Acid	79-97	induction of brown adipocytes 1	Mus musculus	123-128
30065264-0	2018	GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate.	2-Aminoadipic Acid	103-117	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
30429952-1	2018	The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported.	2-Aminoadipic Acid	91-109	folate hydrolase 1	Homo sapiens	28-62
30429952-1	2018	The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported.	2-Aminoadipic Acid	91-109	folate hydrolase 1	Homo sapiens	64-68
30429952-1	2018	The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported.	2-Aminoadipic Acid	91-109	folate hydrolase 1	Homo sapiens	175-179
30197589-5	2018	L-alpha-aminoadipic acid (L-alpha-AAA), an astrocyte-selective gliotoxin, was injected into the hippocampal CA3 region of rats through a cranial window to selectively damage astrocytes.	2-Aminoadipic Acid	0-24	carbonic anhydrase 3	Rattus norvegicus	108-111
30065264-5	2018	Lack of GM-CSF driven myeloid cells lead to reduced adipose tissue 2-oxoglutarate dehydrogenase complex (DHTKD1) levels and subsequent increase in plasma 2-aminoadipate (2-AA) levels, both of which are reported to correlate with insulin resistance.	2-Aminoadipic Acid	154-168	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	8-14
30065264-5	2018	Lack of GM-CSF driven myeloid cells lead to reduced adipose tissue 2-oxoglutarate dehydrogenase complex (DHTKD1) levels and subsequent increase in plasma 2-aminoadipate (2-AA) levels, both of which are reported to correlate with insulin resistance.	2-Aminoadipic Acid	170-174	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	8-14
26708453-1	2016	In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.	2-Aminoadipic Acid	169-183	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	80-86
29661920-6	2018	Moreover, DHTKD1 deficiency causes severe metabolic abnormalities and dramatically increased levels of 2-ketoadipic acid (2-KAA) and 2-aminoadipic acid (2-AAA) in urine.	2-Aminoadipic Acid	133-151	dehydrogenase E1 and transketolase domain containing 1	Mus musculus	10-16
29661920-6	2018	Moreover, DHTKD1 deficiency causes severe metabolic abnormalities and dramatically increased levels of 2-ketoadipic acid (2-KAA) and 2-aminoadipic acid (2-AAA) in urine.	2-Aminoadipic Acid	153-158	dehydrogenase E1 and transketolase domain containing 1	Mus musculus	10-16
26842543-5	2017	RESULTS: After 3 months, AAD treatment statistically significantly improved BS (P < 0.05); at 6 months, AAD treatment statistically significantly improved indexes PD, PI, BOP and BS (P < 0.05).	2-Aminoadipic Acid	107-110	BOP	Homo sapiens	174-177
28069522-0	2017	Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.	2-Aminoadipic Acid	60-78	myeloperoxidase	Homo sapiens	0-15
27175011-6	2016	Intrathecal co-administration of L-alpha-aminoadipate, an astroglial toxin, with PACAP or maxadilan almost completely prevented the induction of the mechanical allodynia.	2-Aminoadipic Acid	33-53	adenylate cyclase activating polypeptide 1	Mus musculus	81-86
27175011-7	2016	Furthermore, intrathecal treatment of L-alpha-aminoadipate at 84 days after the PAC1 stimulation transiently reversed the mechanical allodynia accompanied by the reduction of glial fibrillary acidic protein expression level.	2-Aminoadipic Acid	38-58	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	80-84
26829444-9	2016	Eleven metabolites allowed differentiation between both diabetes types and alanine, alpha-amino-adipic acid, isoleucin, and stearic acid showed an inverse association with insulin sensitivity in both T2D and T1D combined.	2-Aminoadipic Acid	84-107	insulin	Homo sapiens	172-179
26967762-10	2016	Growth on pipecolate was retarded in the gcdG and gcdH mutants, suggesting the importance of glutarate in pipecolate and 2-aminoadipate utilization.	2-Aminoadipic Acid	121-135	glutaryl-CoA dehydrogenase	Pseudomonas aeruginosa PAO1	50-54
29045138-1	2017	Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	2-Aminoadipic Acid	119-137	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-26
29045138-1	2017	Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	2-Aminoadipic Acid	119-137	aldehyde dehydrogenase 7 family member A1	Homo sapiens	28-35
29045138-2	2017	Structures of ALDH7A1 reveal the C-terminus is a gate that opens and closes in response to the binding of alpha-aminoadipate.	2-Aminoadipic Acid	106-124	aldehyde dehydrogenase 7 family member A1	Homo sapiens	14-21
28625859-7	2017	This opinion was proved by the results that administration of mice with l-Alpha-Aminoadipic Acid (L-AAA), a gliotoxin specific for astrocytes, attenuated the antidepressant-like effects of harmine, and prevented the improvement effects of harmine on BDNF protein levels and hippocampal neurogenesis.	2-Aminoadipic Acid	72-96	brain derived neurotrophic factor	Mus musculus	250-254
28625859-7	2017	This opinion was proved by the results that administration of mice with l-Alpha-Aminoadipic Acid (L-AAA), a gliotoxin specific for astrocytes, attenuated the antidepressant-like effects of harmine, and prevented the improvement effects of harmine on BDNF protein levels and hippocampal neurogenesis.	2-Aminoadipic Acid	98-103	brain derived neurotrophic factor	Mus musculus	250-254
26977812-0	2016	Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping.	2-Aminoadipic Acid	104-129	tight junction protein 1	Rattus norvegicus	85-89
26977812-4	2016	Thus, we hypothesized that AAA treatment alters the cone mosaic rings by disrupting the distal sealing formed by these fibrotic processes, either directly or indirectly, by down regulating the expression of ZO-1.	2-Aminoadipic Acid	27-30	tight junction protein 1	Rattus norvegicus	207-211
26977812-6	2016	Moreover, ZO-1 expression is actively suppressed after 3 days of AAA treatment, which coincided with cone ring disruption.	2-Aminoadipic Acid	65-68	tight junction protein 1	Rattus norvegicus	10-14
26209257-8	2015	The nociceptive behavior produced by Ang II or III was also attenuated by the administration of the astrocytic inhibitor L-alpha-aminoadipic acid, but not by the microglial inhibitor minocycline.	2-Aminoadipic Acid	121-145	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	37-43
26400963-10	2015	The greater postprandial rise in 2-aminoadipic acid after the beef meal, coupled to its proposed role in stimulating insulin secretion, may have importance in the context of red meat intake and increased diabetes risk.	2-Aminoadipic Acid	33-51	insulin	Homo sapiens	117-124
26260980-1	2015	Aldehyde dehydrogenase 7A1 (ALDH7A1) is part of lysine catabolism and catalyzes the NAD(+)-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	2-Aminoadipic Acid	114-132	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-26
26325079-1	2015	Homoisocitrate dehydrogenase (HIcDH) catalyzes the NAD(+)-dependent oxidative decarboxylation of HIc to alpha-ketoadipate, the fourth step in the alpha-aminoadipate pathway responsible for the de novo synthesis of l-lysine in fungi.	2-Aminoadipic Acid	146-164	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
26325079-1	2015	Homoisocitrate dehydrogenase (HIcDH) catalyzes the NAD(+)-dependent oxidative decarboxylation of HIc to alpha-ketoadipate, the fourth step in the alpha-aminoadipate pathway responsible for the de novo synthesis of l-lysine in fungi.	2-Aminoadipic Acid	146-164	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	30-35
26260980-1	2015	Aldehyde dehydrogenase 7A1 (ALDH7A1) is part of lysine catabolism and catalyzes the NAD(+)-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	2-Aminoadipic Acid	114-132	aldehyde dehydrogenase 7 family member A1	Homo sapiens	28-35
26135545-6	2015	A further analysis was undertaken to investigate the contribution of SGCs; the expression of interleukin-1beta (IL-1beta) in SGCs and interleukin-1 receptor I (IL-1RI) in neurons was significantly increased after chronic restraint stress, whereas injection of L-alpha-aminoadipate (a SGC inhibitor, LAA) into the TG dramatically inhibited the overexpression of these proteins.	2-Aminoadipic Acid	260-280	interleukin 1 beta	Rattus norvegicus	112-120
24216329-6	2014	The intracisternal infusion of minocycline, a microglia inhibitor, and l-alpha-aminoadipic acid, an astrocytic specific inhibitor, also blocked the induced mechanical allodynia and downregulated neuronal GRK2 expression, respectively.	2-Aminoadipic Acid	71-95	G protein-coupled receptor kinase 2	Rattus norvegicus	204-208
25733201-7	2015	Moreover, insulin sensitizer therapy significantly reduced three functionally clustered AA and metabolite pairs: i) phenylalanine/tyrosine, ii) citrulline/arginine, and iii) lysine/alpha-aminoadipic acid.	2-Aminoadipic Acid	181-203	insulin	Homo sapiens	10-17
25686916-0	2015	PEDF counteracts DL-alpha-aminoadipate toxicity and rescues gliotoxic damages in RPE-free chicken retinal explants.	2-Aminoadipic Acid	17-38	serpin family F member 1	Homo sapiens	0-4
25215496-4	2014	Most prominently, Dhtkd1 was identified as a primary regulator of 2-aminoadipate, explaining variance in fasted glucose and diabetes status in both mice and humans.	2-Aminoadipic Acid	66-80	dehydrogenase E1 and transketolase domain containing 1	Mus musculus	18-24
25581615-4	2015	A first subset (n=12) of GSCs exhibited a dramatic accumulation of the metabolite alpha-aminoadipate (alphaAAD), product of the oxidation of alpha-aminoadipic semialdehyde catalyzed by the ALDH7A1 aldehyde dehydrogenase (ALDH) family in lysine catabolism.	2-Aminoadipic Acid	82-100	aldehyde dehydrogenase 7 family member A1	Homo sapiens	189-196
25581615-4	2015	A first subset (n=12) of GSCs exhibited a dramatic accumulation of the metabolite alpha-aminoadipate (alphaAAD), product of the oxidation of alpha-aminoadipic semialdehyde catalyzed by the ALDH7A1 aldehyde dehydrogenase (ALDH) family in lysine catabolism.	2-Aminoadipic Acid	82-100	aldehyde dehydrogenase 7 family member A1	Homo sapiens	189-193
23737455-7	2013	Univariate Cox regression and Kaplan-Meier analyses showed that levels of aminoadipic acid, gluconic acid and maltotriose were associated with the biochemical tumor recurrence (prostate-specific antigen > 0.2 ng/mL).	2-Aminoadipic Acid	74-90	kallikrein related peptidase 3	Homo sapiens	177-202
21982920-2	2011	An as yet unidentified PLP-containing aminotransferase is thought to catalyze the formation of alpha-aminoadipate from alpha-ketoadipate in the L-lysine biosynthetic pathway that could be the yeast Aro8 gene product.	2-Aminoadipic Acid	95-113	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	198-202
22842522-0	2012	Oncosecretomics coupled to bioenergetics identifies alpha-amino adipic acid, isoleucine and GABA as potential biomarkers of cancer: Differential expression of c-Myc, Oct1 and KLF4 coordinates metabolic changes.	2-Aminoadipic Acid	52-75	Kruppel like factor 4	Homo sapiens	175-179
21439022-4	2011	The transamination and the beta-lytic activity of KATII towards the substrates kynurenine and alpha-aminoadipate, the substrate analog beta-chloroalanine and the inhibitors (R)-2-amino-4-(4-(ethylsulfonyl))-4-oxobutanoic acid and cysteine sulfinate were investigated with both conventional assays and a novel continuous spectrophotometric assay.	2-Aminoadipic Acid	94-112	aminoadipate aminotransferase	Homo sapiens	50-55