PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33857805-0	2021	Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	high mobility group box 1	Rattus norvegicus	97-102
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	dynactin subunit 6	Homo sapiens	139-142
33883905-9	2021	Similarly, calycosin also downregulated Snail family transcriptional repressor 1, E-cadherin, and beta-catenin and inhibited cell migration.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	snail family transcriptional repressor 1	Homo sapiens	40-80
33883905-9	2021	Similarly, calycosin also downregulated Snail family transcriptional repressor 1, E-cadherin, and beta-catenin and inhibited cell migration.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	cadherin 1	Homo sapiens	82-92
33883905-9	2021	Similarly, calycosin also downregulated Snail family transcriptional repressor 1, E-cadherin, and beta-catenin and inhibited cell migration.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	catenin beta 1	Homo sapiens	98-110
33883905-11	2021	Conclusion: In summary, calycosin induces apoptosis via ROS-mediated MAPK/STAT3/NF-kappaB pathways, thereby exerting its anti-carcinogenic functions in GC cells.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	signal transducer and activator of transcription 3	Homo sapiens	74-79
33883905-11	2021	Conclusion: In summary, calycosin induces apoptosis via ROS-mediated MAPK/STAT3/NF-kappaB pathways, thereby exerting its anti-carcinogenic functions in GC cells.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	nuclear factor kappa B subunit 1	Homo sapiens	80-89
33883905-0	2021	Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-kappaB Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Homo sapiens	74-79
33883905-0	2021	Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-kappaB Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor kappa B subunit 1	Homo sapiens	80-89
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor kappa B subunit 1	Homo sapiens	82-104
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor kappa B subunit 1	Homo sapiens	106-115
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Homo sapiens	122-172
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Homo sapiens	174-179
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 14	Homo sapiens	226-229
33883905-6	2021	Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor kappa B subunit 1	Homo sapiens	273-282
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin dependent kinase 2	Homo sapiens	48-73
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin dependent kinase 2	Homo sapiens	75-79
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin dependent kinase 4	Homo sapiens	82-86
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin dependent kinase 6	Homo sapiens	88-92
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin D1	Homo sapiens	94-103
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	H3 histone pseudogene 16	Homo sapiens	131-134
33857805-0	2021	Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	103-108
33857805-0	2021	Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	NLR family, pyrin domain containing 3	Rattus norvegicus	131-136
33857805-16	2021	CONCLUSION: CAL alleviates sepsis-induced ALI in young rats by inhibiting the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation.	7,3'-dihydroxy-4'-methoxyisoflavone	12-15	high mobility group box 1	Rattus norvegicus	78-83
33857805-16	2021	CONCLUSION: CAL alleviates sepsis-induced ALI in young rats by inhibiting the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation.	7,3'-dihydroxy-4'-methoxyisoflavone	12-15	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	84-89
33857805-16	2021	CONCLUSION: CAL alleviates sepsis-induced ALI in young rats by inhibiting the HMGB1/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation.	7,3'-dihydroxy-4'-methoxyisoflavone	12-15	NLR family, pyrin domain containing 3	Rattus norvegicus	112-117
33647882-4	2021	Here we provide evidence for the presence of a positive feedback loop between ERalpha and long noncoding RNA RP11-65M17.3 in both normal and cancer cells, and calycosin stimulated this feedback loop in ECs but decreased RP11-65M17.3 expression in BCCs.	7,3'-dihydroxy-4'-methoxyisoflavone	159-168	DNA segment, Chr 17, Roswell Park 11, expressed	Mus musculus	220-224
33647882-0	2021	Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	DNA segment, Chr 17, Roswell Park 11, expressed	Mus musculus	120-124
33647882-5	2021	Subsequently, the calycosin-induced activation of this loop decreased the expression of the target of BRIP1 (BRCA1 interacting protein C-terminal helicase 1), increased the phosphorylation of Akt and ERK1/2, and finally inhibited the cleavage of PARP-1 in ECs.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	BRCA1 interacting protein C-terminal helicase 1	Mus musculus	102-107
33647882-0	2021	Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	BRCA1 interacting protein C-terminal helicase 1	Mus musculus	134-139
33647882-0	2021	Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1 (alpha)	Mus musculus	144-151
33647882-3	2021	In the present study, we show that the phytoestrogen calycosin (20 muM) stimulated the proliferation of ECs (HUVECs and HMEC-1) but inhibited the growth of breast cancer cells (BCCs) expressing ERalpha (MCF-7 and T47D).	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	estrogen receptor 1 (alpha)	Mus musculus	194-201
33647882-5	2021	Subsequently, the calycosin-induced activation of this loop decreased the expression of the target of BRIP1 (BRCA1 interacting protein C-terminal helicase 1), increased the phosphorylation of Akt and ERK1/2, and finally inhibited the cleavage of PARP-1 in ECs.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	BRCA1 interacting protein C-terminal helicase 1	Mus musculus	109-156
33647882-5	2021	Subsequently, the calycosin-induced activation of this loop decreased the expression of the target of BRIP1 (BRCA1 interacting protein C-terminal helicase 1), increased the phosphorylation of Akt and ERK1/2, and finally inhibited the cleavage of PARP-1 in ECs.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	thymoma viral proto-oncogene 1	Mus musculus	192-195
33647882-5	2021	Subsequently, the calycosin-induced activation of this loop decreased the expression of the target of BRIP1 (BRCA1 interacting protein C-terminal helicase 1), increased the phosphorylation of Akt and ERK1/2, and finally inhibited the cleavage of PARP-1 in ECs.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	mitogen-activated protein kinase 3	Mus musculus	200-206
33647882-5	2021	Subsequently, the calycosin-induced activation of this loop decreased the expression of the target of BRIP1 (BRCA1 interacting protein C-terminal helicase 1), increased the phosphorylation of Akt and ERK1/2, and finally inhibited the cleavage of PARP-1 in ECs.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	poly (ADP-ribose) polymerase family, member 1	Mus musculus	246-252
33301850-0	2021	Inhibition of tau aggregation and associated cytotoxicity on neuron-like cells by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	microtubule associated protein tau	Homo sapiens	14-17
33301850-1	2021	In this study, the in vitro assembly of tau and anti-amyloidogenic properties of one naturally occurring phytoestrogen, calycosin, was investigated by spectroscopic techniques including ThT and ANS fluorescence, CD, Congo red absorbance as well as TEM analysis.	7,3'-dihydroxy-4'-methoxyisoflavone	120-129	microtubule associated protein tau	Homo sapiens	40-43
33301850-4	2021	Congo red absorbance and CD studies indicated that calycosin prevented the formation of tau aggregate species and beta-sheets structures, respectively.	7,3'-dihydroxy-4'-methoxyisoflavone	51-60	microtubule associated protein tau	Homo sapiens	88-91
33301850-5	2021	TEM analysis also determined the capacity of calycosin to inhibit tau fibrillogenesis through formation of large amorphous aggregates.	7,3'-dihydroxy-4'-methoxyisoflavone	45-54	microtubule associated protein tau	Homo sapiens	66-69
33301850-6	2021	Furthermore, cellular assays disclosed that calycosin mitigated the cell mortality, LDH release, ROS level, and expression of Bax, Bcl-2, and Caspase-3 in both mRNA and protein levels induced by tau amyloid fibrils.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
33301850-6	2021	Furthermore, cellular assays disclosed that calycosin mitigated the cell mortality, LDH release, ROS level, and expression of Bax, Bcl-2, and Caspase-3 in both mRNA and protein levels induced by tau amyloid fibrils.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	BCL2 apoptosis regulator	Homo sapiens	131-136
33301850-6	2021	Furthermore, cellular assays disclosed that calycosin mitigated the cell mortality, LDH release, ROS level, and expression of Bax, Bcl-2, and Caspase-3 in both mRNA and protein levels induced by tau amyloid fibrils.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	caspase 3	Homo sapiens	142-151
33301850-6	2021	Furthermore, cellular assays disclosed that calycosin mitigated the cell mortality, LDH release, ROS level, and expression of Bax, Bcl-2, and Caspase-3 in both mRNA and protein levels induced by tau amyloid fibrils.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	microtubule associated protein tau	Homo sapiens	195-198
33301850-7	2021	In conclusion, this data may suggest that calycosin can prevent tau amyloid fibrillation and the associated cytotoxicity, mainly due to its effects on formation of lower content of oligomeric and fibrillar aggregates with lower solvent-exposed hydrophobic patches compared to those produced in the absence of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	microtubule associated protein tau	Homo sapiens	64-67
33188878-6	2021	The western blot assay showed calycosin decreased the expression of Bcl-2 and increased the expression of Bax, caspase-3, and PARP.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	BCL2 apoptosis regulator	Homo sapiens	68-73
33188878-6	2021	The western blot assay showed calycosin decreased the expression of Bcl-2 and increased the expression of Bax, caspase-3, and PARP.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
33188878-6	2021	The western blot assay showed calycosin decreased the expression of Bcl-2 and increased the expression of Bax, caspase-3, and PARP.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	caspase 3	Homo sapiens	111-120
33188878-6	2021	The western blot assay showed calycosin decreased the expression of Bcl-2 and increased the expression of Bax, caspase-3, and PARP.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	collagen type XI alpha 2 chain	Homo sapiens	126-130
33188878-7	2021	Calycosin induced the activation of MAPK, STAT3, NF-kappaB, apoptosis-related proteins, and induced cell cycle arrest in the G0/G1 phase by regulating AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Homo sapiens	42-47
33188878-7	2021	Calycosin induced the activation of MAPK, STAT3, NF-kappaB, apoptosis-related proteins, and induced cell cycle arrest in the G0/G1 phase by regulating AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	151-154
33188878-8	2021	In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	transforming growth factor beta 1	Homo sapiens	49-58
33188878-8	2021	In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	SMAD family member 2	Homo sapiens	60-67
33188878-8	2021	In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	snail family transcriptional repressor 2	Homo sapiens	69-73
33188878-8	2021	In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	vimentin	Homo sapiens	79-87
33188878-11	2021	Calycosin resisted HCC by activating ROS-mediated MAPK, STAT3, and NF-kappaB signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Homo sapiens	56-61
32999213-6	2020	In conclusion, calycosin may alleviate Ang II-induced pro-proliferative and anti-apoptotic effects on glomerular mesangial cells at least partially via inhibiting autophagy and ERK signaling pathway, suggesting that calycosin may function as a potential alternative medication for the management of chronic kidney diseases.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	angiotensinogen	Homo sapiens	39-45
33431034-11	2021	In addition to pBD3, other porcine HDP genes such as pBD2, PG1-5, and pEP2C were induced to different magnitudes by xanthohumol, deoxyshikonin, isorhapontigenin, and calycosin, although clear gene- and cell type-specific patterns of regulation were observed.	7,3'-dihydroxy-4'-methoxyisoflavone	166-175	defensin beta 1	Sus scrofa	53-57
33431034-11	2021	In addition to pBD3, other porcine HDP genes such as pBD2, PG1-5, and pEP2C were induced to different magnitudes by xanthohumol, deoxyshikonin, isorhapontigenin, and calycosin, although clear gene- and cell type-specific patterns of regulation were observed.	7,3'-dihydroxy-4'-methoxyisoflavone	166-175	protegrin-1	Sus scrofa	59-64
32474674-8	2021	Calycosin significantly reduced liver index, MDA level, and ALT and AST activity and increased SOD activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	glutamic pyruvic transaminase, soluble	Mus musculus	60-63
32474674-8	2021	Calycosin significantly reduced liver index, MDA level, and ALT and AST activity and increased SOD activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	68-71
32474674-9	2021	The alpha-SMA, Col-I, and Hyp of the calycosin group were significantly lower than those of the model group.	7,3'-dihydroxy-4'-methoxyisoflavone	37-46	actin alpha 2, smooth muscle, aorta	Mus musculus	4-13
32474674-10	2021	Calycosin increased MMP-1 and inhibited TIMP-1 expression resulting in the improvement of MMP-1/TIMP-1 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 13	Mus musculus	20-25
32474674-10	2021	Calycosin increased MMP-1 and inhibited TIMP-1 expression resulting in the improvement of MMP-1/TIMP-1 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tissue inhibitor of metalloproteinase 1	Mus musculus	40-46
32474674-10	2021	Calycosin increased MMP-1 and inhibited TIMP-1 expression resulting in the improvement of MMP-1/TIMP-1 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 13	Mus musculus	90-95
32474674-10	2021	Calycosin increased MMP-1 and inhibited TIMP-1 expression resulting in the improvement of MMP-1/TIMP-1 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tissue inhibitor of metalloproteinase 1	Mus musculus	96-102
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	estrogen receptor 1 (alpha)	Mus musculus	32-38
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	Janus kinase 2	Mus musculus	59-63
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	68-73
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	Janus kinase 2	Mus musculus	94-98
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	Janus kinase 2	Mus musculus	94-98
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	111-116
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	111-116
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 13	Mus musculus	190-195
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tissue inhibitor of metalloproteinase 1	Mus musculus	196-202
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1 (alpha)	Mus musculus	231-237
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Janus kinase 2	Mus musculus	263-267
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Mus musculus	268-273
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	matrix metallopeptidase 13	Mus musculus	190-195
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	tissue inhibitor of metalloproteinase 1	Mus musculus	196-202
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	estrogen receptor 1 (alpha)	Mus musculus	231-237
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	Janus kinase 2	Mus musculus	263-267
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	signal transducer and activator of transcription 3	Mus musculus	268-273
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	matrix metallopeptidase 13	Mus musculus	190-195
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	tissue inhibitor of metalloproteinase 1	Mus musculus	196-202
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	estrogen receptor 1 (alpha)	Mus musculus	231-237
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	Janus kinase 2	Mus musculus	263-267
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	signal transducer and activator of transcription 3	Mus musculus	268-273
32999213-0	2020	Calycosin may alleviate Ang II-induced pro-proliferative effects on glomerular mesangial cells via partially inhibiting autophagy and ERK signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	angiotensinogen	Homo sapiens	24-30
32999213-0	2020	Calycosin may alleviate Ang II-induced pro-proliferative effects on glomerular mesangial cells via partially inhibiting autophagy and ERK signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 1	Homo sapiens	134-137
32999213-3	2020	The present work aims to explore whether calycosin could affect the growth and apoptosis ability of the Ang II treated glomerular mesangial cells and the underlying mechanism.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	angiotensinogen	Homo sapiens	104-110
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	angiotensinogen	Homo sapiens	14-20
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	angiotensinogen	Homo sapiens	224-230
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	mitogen-activated protein kinase 1	Homo sapiens	267-270
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	angiotensinogen	Homo sapiens	224-230
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	angiotensinogen	Homo sapiens	224-230
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	242-251	angiotensinogen	Homo sapiens	14-20
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	242-251	angiotensinogen	Homo sapiens	14-20
33484002-0	2021	Calycosin modulates inflammation via suppressing TLR4/NF-kappaB pathway and promotes bone formation to ameliorate glucocorticoid-induced osteonecrosis of the femoral head in rat.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	toll-like receptor 4	Rattus norvegicus	49-53
33484002-3	2021	Calycosin, the main bioactive extract of Astragali Radix, could substantially regulate the TLR4/NF-kappaB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	toll-like receptor 4	Rattus norvegicus	91-95
32999213-6	2020	In conclusion, calycosin may alleviate Ang II-induced pro-proliferative and anti-apoptotic effects on glomerular mesangial cells at least partially via inhibiting autophagy and ERK signaling pathway, suggesting that calycosin may function as a potential alternative medication for the management of chronic kidney diseases.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	mitogen-activated protein kinase 1	Homo sapiens	177-180
32999213-6	2020	In conclusion, calycosin may alleviate Ang II-induced pro-proliferative and anti-apoptotic effects on glomerular mesangial cells at least partially via inhibiting autophagy and ERK signaling pathway, suggesting that calycosin may function as a potential alternative medication for the management of chronic kidney diseases.	7,3'-dihydroxy-4'-methoxyisoflavone	216-225	angiotensinogen	Homo sapiens	39-45
32901836-0	2020	Calycosin induces apoptosis via p38-MAPK pathway-mediated activation of the mitochondrial apoptotic pathway in human osteosarcoma 143B cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 14	Homo sapiens	32-35
32901836-0	2020	Calycosin induces apoptosis via p38-MAPK pathway-mediated activation of the mitochondrial apoptotic pathway in human osteosarcoma 143B cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 14	Homo sapiens	36-40
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	caspase 3	Homo sapiens	99-108
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	caspase 9	Homo sapiens	118-127
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	poly(ADP-ribose) polymerase 1	Homo sapiens	137-164
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	169-195
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	197-200
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	BCL2 apoptosis regulator	Homo sapiens	169-174
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	319-322
32901836-8	2020	In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	BCL2 apoptosis regulator	Homo sapiens	293-298
32901836-9	2020	In addition, the expression levels of cytochrome c were markedly decreased in the mitochondria and increased in the cytoplasm following calycosin treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	136-145	cytochrome c, somatic	Homo sapiens	38-50
32901836-10	2020	Furthermore, calycosin treatment induced p38-mitogen-activated protein kinase (MAPK) phosphorylation, whereas the p38-MAPK inhibitor BIRB 796 markedly reversed cell viability, apoptosis and loss of MMP in 143B cells.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	mitogen-activated protein kinase 14	Homo sapiens	41-77
32901836-10	2020	Furthermore, calycosin treatment induced p38-mitogen-activated protein kinase (MAPK) phosphorylation, whereas the p38-MAPK inhibitor BIRB 796 markedly reversed cell viability, apoptosis and loss of MMP in 143B cells.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	mitogen-activated protein kinase 14	Homo sapiens	79-83
32901836-11	2020	These results suggested that calycosin inhibited osteosarcoma 143B cell growth via p38-MAPK regulation of mitochondrial-dependent intrinsic apoptotic pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	mitogen-activated protein kinase 14	Homo sapiens	83-86
32901836-11	2020	These results suggested that calycosin inhibited osteosarcoma 143B cell growth via p38-MAPK regulation of mitochondrial-dependent intrinsic apoptotic pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	mitogen-activated protein kinase 14	Homo sapiens	87-91
32910538-0	2020	Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	115-119
32910538-0	2020	Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	S-phase kinase associated protein 2	Rattus norvegicus	120-124
32910538-9	2020	Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	autophagy related 7	Rattus norvegicus	100-104
32910538-9	2020	Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	127-131
32910538-0	2020	Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	125-130
32910538-9	2020	Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	forkhead box O3	Rattus norvegicus	136-142
32910538-9	2020	Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	S-phase kinase associated protein 2	Rattus norvegicus	158-162
32910538-9	2020	Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	206-211
32910538-8	2020	Calycosin treatment improved bodyweight and renal function, alleviated muscle atrophy (decreased the levels of MuRF1 and MAFbx), increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity and reduced malondialdehyde (MDA) levels in skeletal muscle of CKD rats.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tripartite motif containing 63	Rattus norvegicus	111-116
32910538-11	2020	Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF-alpha-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	tumor necrosis factor	Mus musculus	122-131
32910538-11	2020	Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF-alpha-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	191-195
32910538-8	2020	Calycosin treatment improved bodyweight and renal function, alleviated muscle atrophy (decreased the levels of MuRF1 and MAFbx), increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity and reduced malondialdehyde (MDA) levels in skeletal muscle of CKD rats.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	F-box protein 32	Rattus norvegicus	121-126
32910538-11	2020	Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF-alpha-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	S-phase kinase associated protein 2	Rattus norvegicus	196-200
32910538-11	2020	Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF-alpha-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	201-206
32910538-8	2020	Calycosin treatment improved bodyweight and renal function, alleviated muscle atrophy (decreased the levels of MuRF1 and MAFbx), increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity and reduced malondialdehyde (MDA) levels in skeletal muscle of CKD rats.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	catalase	Rattus norvegicus	167-175
32910538-8	2020	Calycosin treatment improved bodyweight and renal function, alleviated muscle atrophy (decreased the levels of MuRF1 and MAFbx), increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity and reduced malondialdehyde (MDA) levels in skeletal muscle of CKD rats.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	catalase	Rattus norvegicus	177-180
32538204-0	2020	The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	17-26	ring finger protein 38	Mus musculus	129-134
32712290-3	2020	It has been demonstrated that tumor suppressor miR-375 was downregulated in CC and calycosin upregulated miR-375 expression in cerebral ischemia/reperfusion.	7,3'-dihydroxy-4'-methoxyisoflavone	83-92	microRNA 375	Homo sapiens	47-54
32712290-3	2020	It has been demonstrated that tumor suppressor miR-375 was downregulated in CC and calycosin upregulated miR-375 expression in cerebral ischemia/reperfusion.	7,3'-dihydroxy-4'-methoxyisoflavone	83-92	microRNA 375	Homo sapiens	105-112
32712290-4	2020	Thus we supposed that calycosin exerted anti-cancer effect by upregulating miR-375 expression in CC cells.	7,3'-dihydroxy-4'-methoxyisoflavone	22-31	microRNA 375	Homo sapiens	75-82
32712290-9	2020	Calycosin enhanced the apoptotic rate and caspase-3 activity and decreased the number of invaded cells in CC cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	caspase 3	Homo sapiens	42-51
32712290-10	2020	In addition, we found that miR-375 expression was decreased in CC cells but was upregulated in response to calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	107-116	microRNA 375	Homo sapiens	27-34
32712290-11	2020	Mechanistically, knockdown of miR-375 significantly reversed the anti-cancer effect of calycosin on CC cells.	7,3'-dihydroxy-4'-methoxyisoflavone	87-96	microRNA 375	Homo sapiens	30-37
32538204-6	2020	Beta cell proliferation was assessed by CCK-8 assay.Results: Our data indicated that administration of calycosin significantly improved the GDM symptoms in pregnant db/+ mice as demonstrated by reduced blood glucose, TNF-a, and IL-6 levels as well as increased insulin level, and body weight.	7,3'-dihydroxy-4'-methoxyisoflavone	103-112	tumor necrosis factor	Mus musculus	217-222
32538204-6	2020	Beta cell proliferation was assessed by CCK-8 assay.Results: Our data indicated that administration of calycosin significantly improved the GDM symptoms in pregnant db/+ mice as demonstrated by reduced blood glucose, TNF-a, and IL-6 levels as well as increased insulin level, and body weight.	7,3'-dihydroxy-4'-methoxyisoflavone	103-112	interleukin 6	Mus musculus	228-232
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	89-98	ring finger protein 38	Mus musculus	30-35
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	89-98	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	36-41
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	89-98	signal transducer and activator of transcription 3	Mus musculus	42-47
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	194-203	ring finger protein 38	Mus musculus	153-158
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	194-203	ring finger protein 38	Mus musculus	153-158
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	tumor protein p53	Homo sapiens	115-118
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	tumor protein p53	Homo sapiens	120-124
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	mitogen-activated protein kinase 14	Homo sapiens	127-162
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	mitogen-activated protein kinase 14	Homo sapiens	164-170
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	caspase 8	Homo sapiens	173-182
32417523-9	2020	In a study in vivo, calycosin-treated high fat diet (HFD)-fed mice exhibited reduced liver weights, decreased fasting serum glucose and insulin, liver functional transaminases, blood lipids, metabolic enzymes, and inflammatory cytokines.	7,3'-dihydroxy-4'-methoxyisoflavone	20-29	insulin	Homo sapiens	136-143
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	caspase 8	Homo sapiens	184-189
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	mitogen-activated protein kinase 3	Homo sapiens	192-226
32417523-10	2020	And the data in gene tests displayed up-regulations of ALDH2, NPC1 mRNAs, and down-regulation of HMGB1 mRNA in calycosin-treated liver samples.	7,3'-dihydroxy-4'-methoxyisoflavone	111-120	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	55-60
32417523-10	2020	And the data in gene tests displayed up-regulations of ALDH2, NPC1 mRNAs, and down-regulation of HMGB1 mRNA in calycosin-treated liver samples.	7,3'-dihydroxy-4'-methoxyisoflavone	111-120	NPC intracellular cholesterol transporter 1	Mus musculus	62-66
32417523-10	2020	And the data in gene tests displayed up-regulations of ALDH2, NPC1 mRNAs, and down-regulation of HMGB1 mRNA in calycosin-treated liver samples.	7,3'-dihydroxy-4'-methoxyisoflavone	111-120	high mobility group box 1	Mus musculus	97-102
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	mitogen-activated protein kinase 3	Homo sapiens	228-233
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	caspase 3	Homo sapiens	236-245
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	caspase 3	Homo sapiens	247-252
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	receptor interacting serine/threonine kinase 1	Homo sapiens	255-292
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	receptor interacting serine/threonine kinase 1	Homo sapiens	294-299
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	estrogen receptor 1	Homo sapiens	330-349
32449282-5	2020	As results, the bioinformatic findings showed the core anti-NPC targets played by calycosin included tumor protein p53 (TP53), mitogen-activated protein kinase 14 (MAPK14), caspase 8 (CASP8), mitogen-activated protein kinase 3 (MAPK3), caspase 3 (CASP3), receptor interacting protein kinase 1 (RIPK1), proto-oncogene c (JUN), and estrogen receptor 1 (ESR1).	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	estrogen receptor 1	Homo sapiens	351-355
32449282-10	2020	Following the immunostaining assays, the results indicated increased TP53-, CASP8-positive cells, and reduced MAPK14-positive cells in calycosin-treated NPC cells and xenograft tumor sections.	7,3'-dihydroxy-4'-methoxyisoflavone	135-144	mitogen-activated protein kinase 14	Homo sapiens	110-116
32116027-5	2020	It was observed that calycosin repressed oxidative stress by enhancing Nrf2 anti-oxidative pathway and suppressed inflammation by blocking NACHT, NALP3 inflammasome and NF-kappaB pathway activation.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75
32179199-10	2020	As showed in immunostaining, calycosin-treated OS cells exhibited intracellular up-regulation of TP53, CASP3 expressions, and decreased XIAP expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	tumor protein p53	Homo sapiens	97-101
32179199-10	2020	As showed in immunostaining, calycosin-treated OS cells exhibited intracellular up-regulation of TP53, CASP3 expressions, and decreased XIAP expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	caspase 3	Homo sapiens	103-108
32179199-10	2020	As showed in immunostaining, calycosin-treated OS cells exhibited intracellular up-regulation of TP53, CASP3 expressions, and decreased XIAP expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	X-linked inhibitor of apoptosis	Homo sapiens	136-140
32236598-6	2020	Furthermore, increased ERbeta expression was detected in OS MG-63 cells treated with calycosin, and an ERbeta inhibitor (PHTPP) reversed calycosin-induced cytotoxicity and apoptosis.	7,3'-dihydroxy-4'-methoxyisoflavone	85-94	estrogen receptor 1	Homo sapiens	23-29
32236598-6	2020	Furthermore, increased ERbeta expression was detected in OS MG-63 cells treated with calycosin, and an ERbeta inhibitor (PHTPP) reversed calycosin-induced cytotoxicity and apoptosis.	7,3'-dihydroxy-4'-methoxyisoflavone	137-146	estrogen receptor 1	Homo sapiens	23-29
32236598-6	2020	Furthermore, increased ERbeta expression was detected in OS MG-63 cells treated with calycosin, and an ERbeta inhibitor (PHTPP) reversed calycosin-induced cytotoxicity and apoptosis.	7,3'-dihydroxy-4'-methoxyisoflavone	137-146	estrogen receptor 1	Homo sapiens	103-109
32236598-7	2020	Moreover, phosphorylation levels of PI3K and Akt were significantly downregulated after calycosin treatment, whereas PHTPP reversed their phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	88-97	AKT serine/threonine kinase 1	Homo sapiens	45-48
32236598-9	2020	Thus, the present results indicated that calycosin inhibited proliferation and induced apoptosis in OS MG-63 cells, and that these effects were mediated by ERbeta-dependent inhibition of the PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	estrogen receptor 1	Homo sapiens	156-162
32236598-9	2020	Thus, the present results indicated that calycosin inhibited proliferation and induced apoptosis in OS MG-63 cells, and that these effects were mediated by ERbeta-dependent inhibition of the PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	AKT serine/threonine kinase 1	Homo sapiens	196-199
32606591-11	2020	Western blot and immunohistochemistry analysis showed that the increased protein expression levels of NF-kappaB, p-NF-kappaB, DARPP-32 and STAT3 in the model group were downregulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	186-195	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	126-134
32606591-11	2020	Western blot and immunohistochemistry analysis showed that the increased protein expression levels of NF-kappaB, p-NF-kappaB, DARPP-32 and STAT3 in the model group were downregulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	186-195	signal transducer and activator of transcription 3	Rattus norvegicus	139-144
32606591-12	2020	The upregulation of integrin beta1 expression induced by MNNG was decreased in the calycosin groups.	7,3'-dihydroxy-4'-methoxyisoflavone	83-92	integrin subunit beta 1	Rattus norvegicus	20-34
32606591-13	2020	Conclusion: Collectively, calycosin protected against gastric mucosal injury in part via regulation of the integrin beta1/NF-kappaB/DARPP-32 pathway and suppressed the expression of STAT3 in PLGC.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	integrin subunit beta 1	Rattus norvegicus	107-121
32606591-13	2020	Conclusion: Collectively, calycosin protected against gastric mucosal injury in part via regulation of the integrin beta1/NF-kappaB/DARPP-32 pathway and suppressed the expression of STAT3 in PLGC.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	132-140
32606591-13	2020	Conclusion: Collectively, calycosin protected against gastric mucosal injury in part via regulation of the integrin beta1/NF-kappaB/DARPP-32 pathway and suppressed the expression of STAT3 in PLGC.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	signal transducer and activator of transcription 3	Rattus norvegicus	182-187
32236598-0	2020	Calycosin induces apoptosis in osteosarcoma cell line via ERbeta-mediated PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Homo sapiens	58-64
32236598-0	2020	Calycosin induces apoptosis in osteosarcoma cell line via ERbeta-mediated PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	79-82
32236598-1	2020	Previous studies have shown that calycosin, a natural phytoestrogen which is structurally similar to estrogen, inhibits proliferation and induces apoptosis in estrogen-dependent cancer types via the estrogen receptor (ER)beta-induced inhibition of PI3K/Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	33-42	estrogen receptor 1	Homo sapiens	199-216
32236598-1	2020	Previous studies have shown that calycosin, a natural phytoestrogen which is structurally similar to estrogen, inhibits proliferation and induces apoptosis in estrogen-dependent cancer types via the estrogen receptor (ER)beta-induced inhibition of PI3K/Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	33-42	estrogen receptor 1	Homo sapiens	218-225
32236598-1	2020	Previous studies have shown that calycosin, a natural phytoestrogen which is structurally similar to estrogen, inhibits proliferation and induces apoptosis in estrogen-dependent cancer types via the estrogen receptor (ER)beta-induced inhibition of PI3K/Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	33-42	AKT serine/threonine kinase 1	Homo sapiens	253-256
32087226-0	2020	Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	monoamine oxidase B	Homo sapiens	119-138
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	monoamine oxidase B	Homo sapiens	128-134
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	latexin	Homo sapiens	157-160
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	monoamine oxidase A	Homo sapiens	184-190
32116027-5	2020	It was observed that calycosin repressed oxidative stress by enhancing Nrf2 anti-oxidative pathway and suppressed inflammation by blocking NACHT, NALP3 inflammasome and NF-kappaB pathway activation.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	NLR family, pyrin domain containing 3	Mus musculus	146-151
32106002-11	2020	Further mechanistic study suggests that induction of the Raf/MEK/ERK pathway and facilitated polarization of M2 tumor-associated macrophage in the tumor microenvironment both contribute to the pro-metastatic potential of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	221-230	mitogen-activated protein kinase 1	Homo sapiens	65-68
32099327-9	2020	Conclusion: Calycosin inhibits the catalytic activities of CYP1A2, CYP2D6 and CYP2C9.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	59-65
32106002-0	2020	The dual roles of calycosin in growth inhibition and metastatic progression during pancreatic cancer development: A "TGF-beta paradox".	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	transforming growth factor alpha	Homo sapiens	117-125
32106002-8	2020	RESULTS: Calycosin inhibited the growth of pancreatic cancer cells by inducing p21Waf1/Cip1-induced cell cycle arrest and caspase-dependent apoptosis.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-91
32106002-11	2020	Further mechanistic study suggests that induction of the Raf/MEK/ERK pathway and facilitated polarization of M2 tumor-associated macrophage in the tumor microenvironment both contribute to the pro-metastatic potential of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	221-230	mitogen-activated protein kinase kinase 7	Homo sapiens	61-64
31858651-0	2020	Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	sirtuin 1	Rattus norvegicus	114-123
32099327-9	2020	Conclusion: Calycosin inhibits the catalytic activities of CYP1A2, CYP2D6 and CYP2C9.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	67-73
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	sirtuin 1	Homo sapiens	101-106
31726037-0	2020	Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	interleukin 33	Rattus norvegicus	85-90
31726037-0	2020	Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression.	7,3'-dihydroxy-4'-methoxyisoflavone	25-34	interleukin 1 receptor-like 1	Rattus norvegicus	91-94
31726037-6	2020	Calycosin is an isoflavone with reported IL33 signaling inhibitory activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 33	Rattus norvegicus	41-45
31726037-10	2020	Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling, inflammatory cytokines, oxidative stress and fibrotic processes.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 33	Rattus norvegicus	107-111
31726037-10	2020	Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling, inflammatory cytokines, oxidative stress and fibrotic processes.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 1 receptor-like 1	Rattus norvegicus	112-115
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	107-111
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	134-137
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	138-142
31276230-7	2019	Calycosin inhibited cell growth, proliferation and invasion and increased protein levels of Beclin-1 and LC3II, markers of autophagy.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	beclin 1	Homo sapiens	92-100
31276230-11	2019	Interestingly, co-incubating the cells with either EX-527 or IGF-1 completely prevented Calycosin-induced autophagy and all other associated effects and increased cell invasion.	7,3'-dihydroxy-4'-methoxyisoflavone	88-97	insulin like growth factor 1	Homo sapiens	61-66
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	sirtuin 1	Homo sapiens	96-101
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	140-144
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	AKT serine/threonine kinase 1	Homo sapiens	167-170
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	mechanistic target of rapamycin kinase	Homo sapiens	171-175
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	AKT serine/threonine kinase 1	Homo sapiens	154-159
31502574-7	2019	Additionally, the expression levels of c-Met, MMP9 and p-AKT were inhibited by calycosin in c-Met overexpressed cells.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	39-44
31502574-0	2019	Calycosin down-regulates c-Met to suppress development of glioblastomas.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	25-30
31502574-7	2019	Additionally, the expression levels of c-Met, MMP9 and p-AKT were inhibited by calycosin in c-Met overexpressed cells.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	matrix metallopeptidase 9	Homo sapiens	46-50
31502574-2	2019	In this study we focused on revealing c-Met as a potential target of calycosin suppressing glioblastomas.	7,3'-dihydroxy-4'-methoxyisoflavone	69-78	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	38-43
31502574-7	2019	Additionally, the expression levels of c-Met, MMP9 and p-AKT were inhibited by calycosin in c-Met overexpressed cells.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	AKT serine/threonine kinase 1	Homo sapiens	57-60
31502574-7	2019	Additionally, the expression levels of c-Met, MMP9 and p-AKT were inhibited by calycosin in c-Met overexpressed cells.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	92-97
31502574-9	2019	These data collectively indicated that calycosin possibility targeting on c-Met and exert an anti-tumor role via MMP9 and AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	74-79
31502574-9	2019	These data collectively indicated that calycosin possibility targeting on c-Met and exert an anti-tumor role via MMP9 and AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	matrix metallopeptidase 9	Homo sapiens	113-117
31502574-4	2019	Under treatment of calycosin, the mRNA expression levels of Dtk, c-Met, Lyn and PYK2 were observed in U87 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	TYRO3 protein tyrosine kinase	Homo sapiens	60-63
31502574-9	2019	These data collectively indicated that calycosin possibility targeting on c-Met and exert an anti-tumor role via MMP9 and AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	AKT serine/threonine kinase 1	Homo sapiens	122-125
31502574-4	2019	Under treatment of calycosin, the mRNA expression levels of Dtk, c-Met, Lyn and PYK2 were observed in U87 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	65-70
31551766-9	2019	FRA and CAL improved the content of GM-CSF.	7,3'-dihydroxy-4'-methoxyisoflavone	8-11	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	36-42
31502574-4	2019	Under treatment of calycosin, the mRNA expression levels of Dtk, c-Met, Lyn and PYK2 were observed in U87 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
31502574-4	2019	Under treatment of calycosin, the mRNA expression levels of Dtk, c-Met, Lyn and PYK2 were observed in U87 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	protein tyrosine kinase 2 beta	Homo sapiens	80-84
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	43-48
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	matrix metallopeptidase 9	Homo sapiens	63-90
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	matrix metallopeptidase 9	Homo sapiens	92-96
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	AKT serine/threonine kinase 1	Homo sapiens	149-152
31551766-10	2019	FRA, CAL, and CLG improved the content of EPO.	7,3'-dihydroxy-4'-methoxyisoflavone	5-8	erythropoietin	Mus musculus	42-45
31002890-0	2019	Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	RAB27B, member RAS oncogene family	Homo sapiens	16-22
31002890-0	2019	Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	estrogen receptor 1	Homo sapiens	99-101
31002890-7	2019	Notably, the suppressed expression of Rab27B, beta-catenin and VEGF was found in calycosin-treated MDA-MB-231 cells, accompanied with decreased invasive and migratory potential of these cells.	7,3'-dihydroxy-4'-methoxyisoflavone	81-90	RAB27B, member RAS oncogene family	Homo sapiens	38-44
31002890-7	2019	Notably, the suppressed expression of Rab27B, beta-catenin and VEGF was found in calycosin-treated MDA-MB-231 cells, accompanied with decreased invasive and migratory potential of these cells.	7,3'-dihydroxy-4'-methoxyisoflavone	81-90	catenin beta 1	Homo sapiens	46-58
31002890-7	2019	Notably, the suppressed expression of Rab27B, beta-catenin and VEGF was found in calycosin-treated MDA-MB-231 cells, accompanied with decreased invasive and migratory potential of these cells.	7,3'-dihydroxy-4'-methoxyisoflavone	81-90	vascular endothelial growth factor A	Homo sapiens	63-67
31002890-8	2019	What"s more, these inhibitory effects of calycosin were all attenuated by Rab27B overexpression.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	RAB27B, member RAS oncogene family	Homo sapiens	74-80
31002890-9	2019	The results demonstrated that calycosin-induced inhibition of migration and invasion in ER-negative breast cancer cells may be associated with the inactivation of Rab27B-dependent signaling, and suggest that antagonism of this pathway by calycosin may offer alternative therapeutic strategy for the aggressive breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	RAB27B, member RAS oncogene family	Homo sapiens	163-169
31277716-0	2019	Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	transforming growth factor beta 1	Homo sapiens	36-44
31277716-0	2019	Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	120-125
31277716-0	2019	Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	serpin family E member 1	Homo sapiens	136-141
31277716-0	2019	Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	AKT serine/threonine kinase 1	Homo sapiens	163-166
31163422-0	2019	Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor-beta/Smad Signaling Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	transforming growth factor beta 1	Homo sapiens	72-103
31174572-0	2019	Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	transforming growth factor beta 1	Homo sapiens	21-29
31174572-0	2019	Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	105-110
31174572-0	2019	Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	serpin family E member 1	Homo sapiens	121-126
31174572-1	2019	OBJECTIVES: To determine whether the upregulation of basic leucine zipper ATF-like transcription factor 2 (BATF2) by calycosin suppresses the growth and epithelial-to-mesenchymal transition (EMT) in human colorectal cancer (CRC) cells.	7,3'-dihydroxy-4'-methoxyisoflavone	117-126	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	107-112
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	50-55
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	signal transducer and activator of transcription 3	Homo sapiens	64-114
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	signal transducer and activator of transcription 3	Homo sapiens	116-121
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	transforming growth factor beta 1	Homo sapiens	157-188
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	transforming growth factor beta 1	Homo sapiens	190-198
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	201-210	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	50-55
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	201-210	signal transducer and activator of transcription 3	Homo sapiens	64-114
31174572-8	2019	RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	201-210	signal transducer and activator of transcription 3	Homo sapiens	116-121
31174572-9	2019	TGF-beta promoted cell growth, which was inhibited by calycosin regulating the expression of proliferating cell nuclear antigen (PCNA) via the phosphoinositide 3-kinase pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	transforming growth factor beta 1	Homo sapiens	0-8
31174572-9	2019	TGF-beta promoted cell growth, which was inhibited by calycosin regulating the expression of proliferating cell nuclear antigen (PCNA) via the phosphoinositide 3-kinase pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	proliferating cell nuclear antigen	Homo sapiens	93-127
31174572-9	2019	TGF-beta promoted cell growth, which was inhibited by calycosin regulating the expression of proliferating cell nuclear antigen (PCNA) via the phosphoinositide 3-kinase pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	proliferating cell nuclear antigen	Homo sapiens	129-133
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	108-117	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	108-117	transforming growth factor beta 1	Homo sapiens	141-149
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	108-117	transforming growth factor beta 1	Homo sapiens	141-149
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	108-117	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	248-253
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	108-117	serpin family E member 1	Homo sapiens	264-269
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	transforming growth factor beta 1	Homo sapiens	0-8
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	transforming growth factor beta 1	Homo sapiens	141-149
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	transforming growth factor beta 1	Homo sapiens	141-149
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	248-253
31174572-10	2019	TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1.	7,3'-dihydroxy-4'-methoxyisoflavone	181-190	serpin family E member 1	Homo sapiens	264-269
31174572-11	2019	TGF-beta-induced EMT was inhibited by calycosin in human CRC LoVo and HCT116 cell lines via the Wnt signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	transforming growth factor beta 1	Homo sapiens	0-8
31174572-12	2019	CONCLUSIONS: The induction of BATF2 by calycosin may be a feasible therapeutic option for CRC.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	30-35
31163422-0	2019	Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor-beta/Smad Signaling Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	SMAD family member 4	Homo sapiens	104-108
30632644-0	2019	Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	insulin-like growth factor 1 receptor	Rattus norvegicus	99-104
30830898-0	2019	Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-kappaB Pathway In Vitro and In Vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
30830898-9	2019	Mechanistically, we identified calycosin inhibited diabetes-induced inflammation in kidneys by suppressing the phosphorylation of IKBa and NF-kappaB p65 in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
30830898-9	2019	Mechanistically, we identified calycosin inhibited diabetes-induced inflammation in kidneys by suppressing the phosphorylation of IKBa and NF-kappaB p65 in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	149-152
30830898-10	2019	CONCLUSIONS Calycosin significantly ameliorated diabetes-induced renal inflammation in diabetic renal injury by inhibition of the NF-kappaB-dependent signaling pathway in vivo and in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
30632644-0	2019	Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
30632644-3	2019	Since insulin-like growth factor 1 receptor (IGF1R) signaling and phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling have been shown to play a pivotal role in regulating osteogenesis, we hypothesized that the osteogenic activity of calycosin is mediated by these signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	236-245	insulin-like growth factor 1 receptor	Rattus norvegicus	6-43
30632644-3	2019	Since insulin-like growth factor 1 receptor (IGF1R) signaling and phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling have been shown to play a pivotal role in regulating osteogenesis, we hypothesized that the osteogenic activity of calycosin is mediated by these signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	236-245	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	101-109
30632644-6	2019	The present results showed that calycosin enhanced cell proliferation, ALP activity and Alizarin Red-S staining in a dose-dependent manner in the range of 10-8 -10-6  M, while an inhibitory effect was observed at 10-5  M. Treatment at the optimal concentration (10-6  M, a physiologically achievable concentration) increased mRNA levels of osteogenic genes and phosphorylation of IGF1R and Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	32-41	insulin-like growth factor 1 receptor	Rattus norvegicus	380-385
30632644-6	2019	The present results showed that calycosin enhanced cell proliferation, ALP activity and Alizarin Red-S staining in a dose-dependent manner in the range of 10-8 -10-6  M, while an inhibitory effect was observed at 10-5  M. Treatment at the optimal concentration (10-6  M, a physiologically achievable concentration) increased mRNA levels of osteogenic genes and phosphorylation of IGF1R and Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	32-41	AKT serine/threonine kinase 1	Rattus norvegicus	390-393
30632644-8	2019	These results suggest that the osteogenic effect of calycosin partly involves the IGF1R/PI3K/Akt signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	52-61	insulin-like growth factor 1 receptor	Rattus norvegicus	82-87
30632644-8	2019	These results suggest that the osteogenic effect of calycosin partly involves the IGF1R/PI3K/Akt signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	52-61	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
29849130-6	2018	In this study we evaluated 14 ingredients from DBT in human hepatic stellate cell line LX-2, and found that astragaloside I (A), levistilide A (L) and calycosin (C) produced synergistic proliferation inhibition on LX-2 cells and TGF-beta1-activated LX-2 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	151-160	transforming growth factor beta 1	Homo sapiens	229-238
30421460-0	2019	Calycosin attenuates MPTP-induced Parkinson"s disease by suppressing the activation of TLR/NF-kappaB and MAPK pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
30421460-13	2019	The TLR/NF-kappaB and MAPK pathways in MPTP-induced PD mice were inhibited by calycosin treatment, which was coincident with experiments in LPS-induced BV2 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	78-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	8-17
30421460-14	2019	Above all, calycosin mitigates PD symptoms through TLR/NF-kappaB and MAPK pathways in mice and cell lines.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
30243825-4	2019	We previously observed that HQ and its three main bioactive compounds, including Astragaloside IV (AS-IV), calycosin (CS) and formononetin (FMNT), could significantly induce the expression of P-gp and BCRP in HepG2 cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	107-116	phosphoglycolate phosphatase	Homo sapiens	192-196
30243825-4	2019	We previously observed that HQ and its three main bioactive compounds, including Astragaloside IV (AS-IV), calycosin (CS) and formononetin (FMNT), could significantly induce the expression of P-gp and BCRP in HepG2 cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	107-116	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	201-205
30243825-4	2019	We previously observed that HQ and its three main bioactive compounds, including Astragaloside IV (AS-IV), calycosin (CS) and formononetin (FMNT), could significantly induce the expression of P-gp and BCRP in HepG2 cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	118-120	phosphoglycolate phosphatase	Homo sapiens	192-196
30243825-4	2019	We previously observed that HQ and its three main bioactive compounds, including Astragaloside IV (AS-IV), calycosin (CS) and formononetin (FMNT), could significantly induce the expression of P-gp and BCRP in HepG2 cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	118-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	201-205
30243825-13	2019	RESULTS: HQ, AS-IV, CS and FMNT significantly upregulated the P-gp and BCRP expression in the liver of wild-type mice.	7,3'-dihydroxy-4'-methoxyisoflavone	20-22	phosphoglycolate phosphatase	Mus musculus	62-66
30243825-13	2019	RESULTS: HQ, AS-IV, CS and FMNT significantly upregulated the P-gp and BCRP expression in the liver of wild-type mice.	7,3'-dihydroxy-4'-methoxyisoflavone	20-22	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	71-75
30312543-0	2018	Inhibition effect of phytoestrogen calycosin on TGF-beta1-induced hepatic stellate cell activation, proliferation, and migration via estrogen receptor beta.	7,3'-dihydroxy-4'-methoxyisoflavone	35-44	transforming growth factor beta 1	Homo sapiens	48-57
30312543-0	2018	Inhibition effect of phytoestrogen calycosin on TGF-beta1-induced hepatic stellate cell activation, proliferation, and migration via estrogen receptor beta.	7,3'-dihydroxy-4'-methoxyisoflavone	35-44	estrogen receptor 2	Homo sapiens	133-155
30312543-9	2018	Importantly, calycosin significantly downregulated the expression of ERbeta protein, while co-treatment with ICI 182,780 partially reversed the ERbeta downregulation.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	estrogen receptor 2	Homo sapiens	69-75
30312543-11	2018	In conclusion, calycosin inhibits proliferation, activation, and migration of TGF-beta1-induced HSCs.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	transforming growth factor beta 1	Homo sapiens	78-87
30182951-3	2018	The aim of this study was to investigate the effects of calycosin on apoptosis of estrogen receptor (ER)-positive and ER-negative human osteosarcoma cell lines and tumor xenografts in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	estrogen receptor 1	Homo sapiens	82-99
30182951-3	2018	The aim of this study was to investigate the effects of calycosin on apoptosis of estrogen receptor (ER)-positive and ER-negative human osteosarcoma cell lines and tumor xenografts in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	estrogen receptor 1	Homo sapiens	101-103
30182951-3	2018	The aim of this study was to investigate the effects of calycosin on apoptosis of estrogen receptor (ER)-positive and ER-negative human osteosarcoma cell lines and tumor xenografts in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	estrogen receptor 1	Homo sapiens	118-120
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	AKT serine/threonine kinase 1	Homo sapiens	73-76
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	mechanistic target of rapamycin kinase	Homo sapiens	77-81
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	219-228	mechanistic target of rapamycin kinase	Homo sapiens	77-81
30182951-10	2018	In the nude mouse MG-63 tumor xenografts, calycosin inhibited tumor growth and regulated the expression levels of apoptosis-related PI3K/AKT/mTOR pathway proteins.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	thymoma viral proto-oncogene 1	Mus musculus	137-140
30182951-10	2018	In the nude mouse MG-63 tumor xenografts, calycosin inhibited tumor growth and regulated the expression levels of apoptosis-related PI3K/AKT/mTOR pathway proteins.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	mechanistic target of rapamycin kinase	Mus musculus	141-145
30182951-11	2018	CONCLUSIONS The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	estrogen receptor 1	Homo sapiens	76-78
30182951-11	2018	CONCLUSIONS The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	AKT serine/threonine kinase 1	Homo sapiens	132-135
30182951-11	2018	CONCLUSIONS The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	mechanistic target of rapamycin kinase	Homo sapiens	136-140
30973105-6	2019	CONCLUSION: Hairy Calycosin can effectively control the lipid peroxidation in liver tissues of rats with NAFLD, and reduce the levels of serum TNF-alpha, IL-6, MDA and FFA, effectively improve the steatosis and inflammation of liver tissue, and down-regulate the expression of CYP2E1, inhibit apoptosis of hepatocytes.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	tumor necrosis factor	Rattus norvegicus	143-152
30973105-6	2019	CONCLUSION: Hairy Calycosin can effectively control the lipid peroxidation in liver tissues of rats with NAFLD, and reduce the levels of serum TNF-alpha, IL-6, MDA and FFA, effectively improve the steatosis and inflammation of liver tissue, and down-regulate the expression of CYP2E1, inhibit apoptosis of hepatocytes.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	interleukin 6	Rattus norvegicus	154-158
30973105-6	2019	CONCLUSION: Hairy Calycosin can effectively control the lipid peroxidation in liver tissues of rats with NAFLD, and reduce the levels of serum TNF-alpha, IL-6, MDA and FFA, effectively improve the steatosis and inflammation of liver tissue, and down-regulate the expression of CYP2E1, inhibit apoptosis of hepatocytes.	7,3'-dihydroxy-4'-methoxyisoflavone	18-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	277-283
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Homo sapiens	60-77
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	120-149
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	157-160
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	161-190
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	192-196
29890468-10	2018	These results suggested that calycosin protects against AP by exerting anti-inflammatory and anti-oxidative stress effects via the p38 MAPK and NF-kappaB signal pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	mitogen-activated protein kinase 14	Mus musculus	131-139
29890468-0	2018	Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-kappaB signal pathways in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 14	Mus musculus	126-134
29890468-0	2018	Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-kappaB signal pathways in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
29890468-8	2018	Calycosin treatment reversed the increased serum levels of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in mice with AP.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	lipase, endothelial	Mus musculus	71-77
29890468-8	2018	Calycosin treatment reversed the increased serum levels of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in mice with AP.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tumor necrosis factor	Mus musculus	159-192
29890468-10	2018	These results suggested that calycosin protects against AP by exerting anti-inflammatory and anti-oxidative stress effects via the p38 MAPK and NF-kappaB signal pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
29890468-8	2018	Calycosin treatment reversed the increased serum levels of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in mice with AP.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 6	Mus musculus	194-212
29595858-0	2018	Calycosin directly improves perivascular adipose tissue dysfunction by upregulating the adiponectin/AMPK/eNOS pathway in obese mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	adiponectin, C1Q and collagen domain containing	Mus musculus	88-99
29890468-8	2018	Calycosin treatment reversed the increased serum levels of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in mice with AP.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 1 beta	Mus musculus	218-226
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	myeloperoxidase	Mus musculus	91-94
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	187-196
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	197-200
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	241-250
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	252-264
29890468-9	2018	Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK.	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	mitogen-activated protein kinase 14	Mus musculus	270-278
29993193-0	2018	Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1alpha.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	109-119
29993193-5	2018	Herein, we have demonstrated that allergic inflammation and the Th2 cytokines in ACD mice were reduced significantly by calycosin treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	120-129	heart and neural crest derivatives expressed 2	Mus musculus	64-67
29993193-6	2018	Meanwhile, calycosin obviously decreased the expression of HIF-1alpha and repaired TJs both in vivo and in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	59-69
29993193-10	2018	These results revealed that calycosin may act as a potential anti-allergy and barrier-repair agent via regulating HIF-1alpha in AD and suggested that HIF-1alpha and TJs might be possible therapy targets for allergic dermatitis.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	hypoxia inducible factor 1, alpha subunit	Mus musculus	114-124
29993193-10	2018	These results revealed that calycosin may act as a potential anti-allergy and barrier-repair agent via regulating HIF-1alpha in AD and suggested that HIF-1alpha and TJs might be possible therapy targets for allergic dermatitis.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	hypoxia inducible factor 1, alpha subunit	Mus musculus	150-160
29595858-10	2018	This beneficial effect of calycosin was eliminated by treatments of blocking adiponectin, AMPK or eNOS.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	adiponectin, C1Q and collagen domain containing	Mus musculus	77-88
29595858-10	2018	This beneficial effect of calycosin was eliminated by treatments of blocking adiponectin, AMPK or eNOS.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	nitric oxide synthase 3, endothelial cell	Mus musculus	98-102
29595858-12	2018	Treatment of obese mice with calycosin significantly increased adiponectin levels, activated AMPK and eNOS phosphorylation and reduced superoxide production and TNF-alpha levels in PVAT.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	adiponectin, C1Q and collagen domain containing	Mus musculus	63-74
29595858-12	2018	Treatment of obese mice with calycosin significantly increased adiponectin levels, activated AMPK and eNOS phosphorylation and reduced superoxide production and TNF-alpha levels in PVAT.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	nitric oxide synthase 3, endothelial cell	Mus musculus	102-106
29595858-12	2018	Treatment of obese mice with calycosin significantly increased adiponectin levels, activated AMPK and eNOS phosphorylation and reduced superoxide production and TNF-alpha levels in PVAT.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	tumor necrosis factor	Mus musculus	161-170
29595858-13	2018	Our results indicated that calycosin restored PVAT induced anti-contractile activity and affected PVAT function through the adiponectin/AMPK/eNOS pathway in obese mice.	7,3'-dihydroxy-4'-methoxyisoflavone	27-36	adiponectin, C1Q and collagen domain containing	Mus musculus	124-135
29595858-13	2018	Our results indicated that calycosin restored PVAT induced anti-contractile activity and affected PVAT function through the adiponectin/AMPK/eNOS pathway in obese mice.	7,3'-dihydroxy-4'-methoxyisoflavone	27-36	nitric oxide synthase 3, endothelial cell	Mus musculus	141-145
29595858-0	2018	Calycosin directly improves perivascular adipose tissue dysfunction by upregulating the adiponectin/AMPK/eNOS pathway in obese mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	105-109
28434978-0	2017	Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	92-98
29643037-7	2018	The cells exposed to high glucose and calycosin treatment showed significantly decreased mRNA levels of alpha-SMA and vimentin (P<0.05) and inhibited phosphorylation of SMAD2/3.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	vimentin	Homo sapiens	118-126
29643037-7	2018	The cells exposed to high glucose and calycosin treatment showed significantly decreased mRNA levels of alpha-SMA and vimentin (P<0.05) and inhibited phosphorylation of SMAD2/3.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	SMAD family member 2	Homo sapiens	172-179
29643037-9	2018	CONCLUSION: In endothelial cells with high glucose-induced injury, calycosin can inhibit the up-regulation of alpha-SMA and vimentin and inhibit phosphorylation of SMAD2/3 to regulate endothelial-mesenchymal transition and improve diabetic nephropathy.	7,3'-dihydroxy-4'-methoxyisoflavone	67-76	vimentin	Homo sapiens	124-132
29643037-9	2018	CONCLUSION: In endothelial cells with high glucose-induced injury, calycosin can inhibit the up-regulation of alpha-SMA and vimentin and inhibit phosphorylation of SMAD2/3 to regulate endothelial-mesenchymal transition and improve diabetic nephropathy.	7,3'-dihydroxy-4'-methoxyisoflavone	67-76	SMAD family member 2	Homo sapiens	164-171
29449812-8	2018	In cultured osteoblasts, the DBT-activated Wnt/beta-catenin and MAPK/Erk and signaling pathways were greatly affected when calycosin was depleted.	7,3'-dihydroxy-4'-methoxyisoflavone	123-132	catenin beta 1	Homo sapiens	47-59
29449812-8	2018	In cultured osteoblasts, the DBT-activated Wnt/beta-catenin and MAPK/Erk and signaling pathways were greatly affected when calycosin was depleted.	7,3'-dihydroxy-4'-methoxyisoflavone	123-132	mitogen-activated protein kinase 1	Homo sapiens	69-72
28699662-8	2018	RESULTS: Calycosin effectively decreased the levels of ALT and AST, increased the levels of adiponectin and insulin.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	glutamic pyruvic transaminase, soluble	Mus musculus	55-58
28699662-8	2018	RESULTS: Calycosin effectively decreased the levels of ALT and AST, increased the levels of adiponectin and insulin.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	63-66
28699662-8	2018	RESULTS: Calycosin effectively decreased the levels of ALT and AST, increased the levels of adiponectin and insulin.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	adiponectin, C1Q and collagen domain containing	Mus musculus	92-103
28699662-12	2018	Further, calycosin suppressed phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, sterol-regulatory element binding protein 1c, and FASN involved in gluconeogenesis and triglyceride synthesis.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	glucose-6-phosphatase, catalytic	Mus musculus	65-86
28699662-12	2018	Further, calycosin suppressed phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, sterol-regulatory element binding protein 1c, and FASN involved in gluconeogenesis and triglyceride synthesis.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	fatty acid synthase	Mus musculus	138-142
28699662-13	2018	Calycosin increased glycogen synthase kinase 3 beta, glucose transporter 4, and phosphorylated insulin receptor substrates 1 and 2 expressions involved in glucose metabolism.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	glycogen synthase kinase 3 beta	Mus musculus	20-51
29402799-9	2018	However, calycosin administration dramatically upregulated the expression of p62, NBR1 and Bcl-2, and downregulated the level of TNF-alpha.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	77-80
29402799-9	2018	However, calycosin administration dramatically upregulated the expression of p62, NBR1 and Bcl-2, and downregulated the level of TNF-alpha.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	NBR1, autophagy cargo receptor	Rattus norvegicus	82-86
29402799-9	2018	However, calycosin administration dramatically upregulated the expression of p62, NBR1 and Bcl-2, and downregulated the level of TNF-alpha.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	BCL2, apoptosis regulator	Rattus norvegicus	91-96
29402799-9	2018	However, calycosin administration dramatically upregulated the expression of p62, NBR1 and Bcl-2, and downregulated the level of TNF-alpha.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	tumor necrosis factor	Rattus norvegicus	129-138
29298702-0	2017	Correction to: Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	WD repeat domain 7	Homo sapiens	97-101
29298702-0	2017	Correction to: Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	G protein-coupled estrogen receptor 1	Homo sapiens	104-109
29096683-0	2017	Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	WD repeat domain 7	Homo sapiens	82-86
29096683-0	2017	Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	89-94
29096683-4	2017	RESULTS: Here, we show that calycosin inhibited the proliferation of both ER- (MDA-MB-468 and SKBR3) and ER+ breast cancer cells (MCF-7 and T47D) and that these inhibitory effects were associated with the up-regulation of the long non-coding RNA (lncRNA) WDR7-7.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	WD repeat domain 7	Homo sapiens	255-259
29096683-6	2017	Meanwhile, we show that calycosin stimulated the WDR7-7-GPR30 signaling pathway in MCF-7, T47D, MDA-MB-468, and SKBR3 breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	WD repeat domain 7	Homo sapiens	49-53
29096683-6	2017	Meanwhile, we show that calycosin stimulated the WDR7-7-GPR30 signaling pathway in MCF-7, T47D, MDA-MB-468, and SKBR3 breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	G protein-coupled estrogen receptor 1	Homo sapiens	56-61
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	G protein-coupled estrogen receptor 1	Homo sapiens	26-31
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	112-115
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	epidermal growth factor receptor	Homo sapiens	117-121
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	mitogen-activated protein kinase 3	Homo sapiens	123-129
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	AKT serine/threonine kinase 1	Homo sapiens	134-137
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	WD repeat domain 7	Homo sapiens	146-150
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	192-201	WD repeat domain 7	Homo sapiens	146-150
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	192-201	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
29239334-7	2017	Calycosin diminished hippocampal beta amyloid, Tau protein, interleukin-1beta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 1 beta	Mus musculus	60-106
29239334-7	2017	Calycosin diminished hippocampal beta amyloid, Tau protein, interleukin-1beta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	acetylcholinesterase	Mus musculus	108-128
28445053-0	2017	Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	84-93	ATP binding cassette subfamily G member 2	Canis lupus familiaris	22-54
29085602-10	2017	Western blot assay was further used to determine the effect of calycosin on both NF-kappaB and mitogen activated protein kinases (MAPK) pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	63-72	mitogen-activated protein kinase 1	Mus musculus	130-134
29085602-14	2017	CONCLUSION: These findings revealed that calycosin successfully ameliorated the effect of DSS-induced colitis in mice, which could be associated with NF-kappaB and JNK pathway modulations.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	mitogen-activated protein kinase 8	Mus musculus	164-167
28434978-0	2017	Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	100-105
28434978-0	2017	Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	110-115
28434978-6	2017	On the other hand, we observed that calycosin could enhance the nuclear translocation of the core transcription factor DAF-16/FoXO instead of the conserved stress-responsive transcription factor SKN-1/Nrf-2.	7,3'-dihydroxy-4'-methoxyisoflavone	36-45	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	119-125
28434978-9	2017	Collectively, our results strongly suggest that calycosin could function as an antioxidant to extend the lifespan of C. elegans by enhancing nucleus translocation of DAF-16 through the insulin-signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	48-57	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	166-172
28368679-0	2017	Calycosin Enhances Some Chemotherapeutic Drugs Inhibition of Akt Signaling Pathway in Gastric Cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	61-64
28596571-0	2017	The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	12-17
28596571-3	2017	The aim of the present study is to test whether calycosin protects against cerebral ischemic injury through TRPC6-CREB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	48-57	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	108-113
28596571-3	2017	The aim of the present study is to test whether calycosin protects against cerebral ischemic injury through TRPC6-CREB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	48-57	cAMP responsive element binding protein 1	Rattus norvegicus	114-118
28596571-6	2017	Our results showed that treatment with calycosin protected against ischemia-induced damages by increasing TRPC6 and P-CREB expression and inhibiting calpain activation.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	106-111
28596571-6	2017	Our results showed that treatment with calycosin protected against ischemia-induced damages by increasing TRPC6 and P-CREB expression and inhibiting calpain activation.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	cAMP responsive element binding protein 1	Rattus norvegicus	118-122
28596571-7	2017	The neuroprotection effect of calycosin was diminished by inhibition or knockdown of TRPC6 and CREB.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	85-90
28596571-7	2017	The neuroprotection effect of calycosin was diminished by inhibition or knockdown of TRPC6 and CREB.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	cAMP responsive element binding protein 1	Rattus norvegicus	95-99
28596571-8	2017	These findings indicated that the potential neuroprotection mechanism of calycosin was involved with TRPC6-CREB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	73-82	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	101-106
28596571-8	2017	These findings indicated that the potential neuroprotection mechanism of calycosin was involved with TRPC6-CREB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	73-82	cAMP responsive element binding protein 1	Rattus norvegicus	107-111
28368679-8	2017	We found that calycosin can enhance the suppression of cisplatin to gastric cell line by inhibiting the phosphorylation of protein kinase B (Akt).	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	AKT serine/threonine kinase 1	Homo sapiens	141-144
28190475-10	2017	RESULTS: Calycosin significantly inhibited body weight loss induced by MCD diet, decreased the ALT and AST activities, MCP-1 and mKC in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	glutamic pyruvic transaminase, soluble	Mus musculus	95-98
28190475-10	2017	RESULTS: Calycosin significantly inhibited body weight loss induced by MCD diet, decreased the ALT and AST activities, MCP-1 and mKC in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	103-106
28190475-10	2017	RESULTS: Calycosin significantly inhibited body weight loss induced by MCD diet, decreased the ALT and AST activities, MCP-1 and mKC in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	mast cell protease 1	Mus musculus	119-124
28190475-13	2017	Immunohistochemistry of a-SMA demonstrated that calycosin attenuated hepatic fibrosis by inhibiting hepatic stellate cell activation.	7,3'-dihydroxy-4'-methoxyisoflavone	48-57	actin alpha 2, smooth muscle, aorta	Mus musculus	24-29
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	sterol regulatory element binding transcription factor 1	Mus musculus	47-55
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	fatty acid synthase	Mus musculus	57-61
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	stearoyl-Coenzyme A desaturase 1	Mus musculus	71-75
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	peroxisome proliferator activated receptor alpha	Mus musculus	139-144
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	carnitine palmitoyltransferase 1b, muscle	Mus musculus	146-150
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	syndecan 1	Mus musculus	152-162
28190475-14	2017	Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	lipoprotein lipase	Mus musculus	167-170
28190475-15	2017	The above effects of calycosin were attributed to FXR activation.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	nuclear receptor subfamily 1, group H, member 4	Mus musculus	50-53
28190475-16	2017	CONCLUSION: Calycosin attenuates triglyceride accumulation and hepatic fibrosis to protect against NASH via FXR activation.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	nuclear receptor subfamily 1, group H, member 4	Mus musculus	108-111
29179209-0	2017	Calycosin Suppresses Epithelial Derived Initiative Key Factors and Maintains Epithelial Barrier in Allergic Inflammation via TLR4 Mediated NF-kappaB Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	toll like receptor 4	Homo sapiens	125-129
28286727-1	2017	By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-beta-d-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast.	7,3'-dihydroxy-4'-methoxyisoflavone	89-98	erythropoietin	Rattus norvegicus	246-249
29241196-0	2017	Calycosin Inhibits the Migration and Invasion of Human Breast Cancer Cells by Down-Regulation of Foxp3 Expression.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	forkhead box P3	Homo sapiens	97-102
29241196-5	2017	Next, the inhibitory effect of higher doses (50, 100 or 150 muM) of calycosin on migration and invasion of the two cell lines was determined by wound healing and transwell assay.	7,3'-dihydroxy-4'-methoxyisoflavone	68-77	latexin	Homo sapiens	60-63
29241196-9	2017	Additionally, treatment with a higher dose of calycosin significantly reduced the expression levels of Foxp3, followed by down-regulation of VEGF and MMP-9 in both MCF-7 and T47D breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	46-55	forkhead box P3	Homo sapiens	103-108
29241196-9	2017	Additionally, treatment with a higher dose of calycosin significantly reduced the expression levels of Foxp3, followed by down-regulation of VEGF and MMP-9 in both MCF-7 and T47D breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	46-55	vascular endothelial growth factor A	Homo sapiens	141-145
29241196-9	2017	Additionally, treatment with a higher dose of calycosin significantly reduced the expression levels of Foxp3, followed by down-regulation of VEGF and MMP-9 in both MCF-7 and T47D breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	46-55	matrix metallopeptidase 9	Homo sapiens	150-155
29241196-10	2017	CONCLUSION: Treatment with a higher dose of calycosin tends to reduce migration and invasion capacity of human breast cancer cells, by targeting Foxp3-mediated VEGF and MMP-9 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	forkhead box P3	Homo sapiens	145-150
29241196-10	2017	CONCLUSION: Treatment with a higher dose of calycosin tends to reduce migration and invasion capacity of human breast cancer cells, by targeting Foxp3-mediated VEGF and MMP-9 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	vascular endothelial growth factor A	Homo sapiens	160-164
29241196-10	2017	CONCLUSION: Treatment with a higher dose of calycosin tends to reduce migration and invasion capacity of human breast cancer cells, by targeting Foxp3-mediated VEGF and MMP-9 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	matrix metallopeptidase 9	Homo sapiens	169-174
29179209-8	2017	RESULTS: The results showed that TSLP and IL-33 were inhibited significantly by calycosin in the initial stage of AD model.	7,3'-dihydroxy-4'-methoxyisoflavone	80-89	thymic stromal lymphopoietin	Homo sapiens	33-37
29179209-8	2017	RESULTS: The results showed that TSLP and IL-33 were inhibited significantly by calycosin in the initial stage of AD model.	7,3'-dihydroxy-4'-methoxyisoflavone	80-89	interleukin 33	Homo sapiens	42-47
29179209-11	2017	Meanwhile, calycosin not only inhibited the expressions of TLR4, MyD88, TAK1 and TIRAP, but also reduced NF-kappaB activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	toll like receptor 4	Homo sapiens	59-63
29179209-11	2017	Meanwhile, calycosin not only inhibited the expressions of TLR4, MyD88, TAK1 and TIRAP, but also reduced NF-kappaB activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	MYD88 innate immune signal transduction adaptor	Homo sapiens	65-70
29179209-11	2017	Meanwhile, calycosin not only inhibited the expressions of TLR4, MyD88, TAK1 and TIRAP, but also reduced NF-kappaB activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	72-76
29179209-11	2017	Meanwhile, calycosin not only inhibited the expressions of TLR4, MyD88, TAK1 and TIRAP, but also reduced NF-kappaB activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	TIR domain containing adaptor protein	Homo sapiens	81-86
29179209-13	2017	CONCLUSION: These results indicated that calycosin reduced the secretion of TSLP/IL-33 and attenuated the disruption of epithelial TJs by inhibiting TLR4 mediated NF-kappaB signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	thymic stromal lymphopoietin	Homo sapiens	76-80
29179209-13	2017	CONCLUSION: These results indicated that calycosin reduced the secretion of TSLP/IL-33 and attenuated the disruption of epithelial TJs by inhibiting TLR4 mediated NF-kappaB signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	interleukin 33	Homo sapiens	81-86
29179209-13	2017	CONCLUSION: These results indicated that calycosin reduced the secretion of TSLP/IL-33 and attenuated the disruption of epithelial TJs by inhibiting TLR4 mediated NF-kappaB signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	toll like receptor 4	Homo sapiens	149-153
27019979-4	2016	Eleven flavonoids showed the induction, and five of them had robust activation of AChE expression, including baicalin, calycosin, genistin, hyperin and pratensein: the induction of AChE included the levels of mRNA, protein and enzymatic activity.	7,3'-dihydroxy-4'-methoxyisoflavone	119-128	acetylcholinesterase	Rattus norvegicus	181-185
27393650-0	2016	Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 2	Homo sapiens	79-85
27678042-0	2016	Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	sequestosome 1	Homo sapiens	84-87
27678042-0	2016	Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
27678042-0	2016	Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	heme oxygenase 1	Homo sapiens	100-116
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	sequestosome 1	Homo sapiens	49-63
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	sequestosome 1	Homo sapiens	65-71
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	sequestosome 1	Homo sapiens	73-76
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	kelch like ECH associated protein 1	Homo sapiens	101-136
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	kelch like ECH associated protein 1	Homo sapiens	138-143
27678042-7	2016	Furthermore, CAL potentiated the accumulation of sequestosome 1 (SQSTM1, p62) and the degradation of Kelch-like ECH-associated protein 1 (Keap1), thereby inducing Nrf2 translocation from the cytoplasm to the nucleus.	7,3'-dihydroxy-4'-methoxyisoflavone	13-16	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
27678042-8	2016	Thus, CAL suppresses the expression of pro-inflammatory cytokines via p62/Nrf2-linked HO-1 induction in RASFs, which suggests that the compound should be further investigated as a candidate anti-inflammatory and anti-arthritic agent.	7,3'-dihydroxy-4'-methoxyisoflavone	6-9	sequestosome 1	Homo sapiens	70-73
27678042-8	2016	Thus, CAL suppresses the expression of pro-inflammatory cytokines via p62/Nrf2-linked HO-1 induction in RASFs, which suggests that the compound should be further investigated as a candidate anti-inflammatory and anti-arthritic agent.	7,3'-dihydroxy-4'-methoxyisoflavone	6-9	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
27393650-0	2016	Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	microRNA 95	Homo sapiens	86-92
27393650-0	2016	Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	insulin like growth factor 1 receptor	Homo sapiens	97-103
29441931-0	2016	Calycosin attenuates osteoporosis and regulates the expression of OPG/RANKL in ovariectomized rats via MAPK signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	TNF receptor superfamily member 11B	Rattus norvegicus	66-69
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	sulfotransferase family 1A member 3	Homo sapiens	151-158
27393650-8	2016	Calycosin increased ERbeta expression and reduced the ERalpha, IGF-1R, and p-Akt expression alongside down-regulation of miR-95 in SW480 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 2	Homo sapiens	20-26
27393650-8	2016	Calycosin increased ERbeta expression and reduced the ERalpha, IGF-1R, and p-Akt expression alongside down-regulation of miR-95 in SW480 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Homo sapiens	54-61
27393650-8	2016	Calycosin increased ERbeta expression and reduced the ERalpha, IGF-1R, and p-Akt expression alongside down-regulation of miR-95 in SW480 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	insulin like growth factor 1 receptor	Homo sapiens	63-69
27393650-8	2016	Calycosin increased ERbeta expression and reduced the ERalpha, IGF-1R, and p-Akt expression alongside down-regulation of miR-95 in SW480 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	microRNA 95	Homo sapiens	121-127
27393650-11	2016	In conclusion, calycosin exerts an inhibitory effect on proliferation of CRC cells in vivo and in vitro, through ERbeta-mediated regulation of the IGF-1R, PI3K/Akt signaling pathways and of miR-95 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	estrogen receptor 2	Homo sapiens	113-119
27393650-11	2016	In conclusion, calycosin exerts an inhibitory effect on proliferation of CRC cells in vivo and in vitro, through ERbeta-mediated regulation of the IGF-1R, PI3K/Akt signaling pathways and of miR-95 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	insulin like growth factor 1 receptor	Homo sapiens	147-153
27393650-11	2016	In conclusion, calycosin exerts an inhibitory effect on proliferation of CRC cells in vivo and in vitro, through ERbeta-mediated regulation of the IGF-1R, PI3K/Akt signaling pathways and of miR-95 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	microRNA 95	Homo sapiens	190-196
26970304-0	2016	Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3beta signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	111-114
26970304-0	2016	Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3beta signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	glycogen synthase kinase 3 beta	Rattus norvegicus	115-124
26970304-6	2016	Treatment with calycosin promoted a reduction in the expression of SYN, PSD-95 and BDNF.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	discs large MAGUK scaffold protein 4	Rattus norvegicus	72-78
26970304-6	2016	Treatment with calycosin promoted a reduction in the expression of SYN, PSD-95 and BDNF.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	brain-derived neurotrophic factor	Rattus norvegicus	83-87
26970304-7	2016	In addition, diabetic rats showed increased MDA levels, and decreased SOD levels and GSH-Px activities in the hippocampus, as well as increased AChE activity in the cerebral cortex; these changes were reversed by calycosin supplementation.	7,3'-dihydroxy-4'-methoxyisoflavone	213-222	acetylcholinesterase	Rattus norvegicus	144-148
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	glycogen synthase kinase 3 beta	Rattus norvegicus	98-107
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	AKT serine/threonine kinase 1	Rattus norvegicus	186-189
26970304-10	2016	In conclusion, calycosin had a beneficial effect on the amelioration, prevention and treatment of diabetes-associated cognitive deficits, through its involvement in oxidative stress, synaptic function and the PI3K/Akt/GSK-3beta pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	AKT serine/threonine kinase 1	Rattus norvegicus	214-217
26970304-10	2016	In conclusion, calycosin had a beneficial effect on the amelioration, prevention and treatment of diabetes-associated cognitive deficits, through its involvement in oxidative stress, synaptic function and the PI3K/Akt/GSK-3beta pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	glycogen synthase kinase 3 beta	Rattus norvegicus	218-227
26956998-0	2016	Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-alpha/ERK1/2 pathway: An in vitro investigation.	7,3'-dihydroxy-4'-methoxyisoflavone	57-66	protein kinase C alpha	Homo sapiens	89-98
26956998-0	2016	Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-alpha/ERK1/2 pathway: An in vitro investigation.	7,3'-dihydroxy-4'-methoxyisoflavone	57-66	mitogen-activated protein kinase 3	Homo sapiens	99-105
29441931-0	2016	Calycosin attenuates osteoporosis and regulates the expression of OPG/RANKL in ovariectomized rats via MAPK signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	TNF superfamily member 11	Rattus norvegicus	70-75
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-31
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	33-38
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	sulfotransferase family 1A member 1	Homo sapiens	40-47
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	phosphoglycolate phosphatase	Homo sapiens	49-53
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	ATP binding cassette subfamily C member 2	Homo sapiens	55-59
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	ATP binding cassette subfamily C member 3	Homo sapiens	65-69
26805467-11	2016	The expression levels of CYP3A4, UGT1A, SULT1A1, P-gp, MRP2, and MRP3 were remarkably increased in the CS-treated cells, whereas the protein levels of SULT1A3 and BCRP were decreased.	7,3'-dihydroxy-4'-methoxyisoflavone	103-105	BCR pseudogene 1	Homo sapiens	163-167
26620254-8	2016	In addition, Akt phosphorylation was upregulated by calycosin mono treatment and downregulated by co-treatment with calycosin and ICI 182,780.	7,3'-dihydroxy-4'-methoxyisoflavone	52-61	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
26620254-8	2016	In addition, Akt phosphorylation was upregulated by calycosin mono treatment and downregulated by co-treatment with calycosin and ICI 182,780.	7,3'-dihydroxy-4'-methoxyisoflavone	116-125	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
26620254-9	2016	These data demonstrated that calycosin exhibits anti-apoptotic effects by activating ERalpha/beta and enhancing Akt phosphorylation in cardiomyocytes.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	estrogen receptor 1	Rattus norvegicus	85-97
26620254-9	2016	These data demonstrated that calycosin exhibits anti-apoptotic effects by activating ERalpha/beta and enhancing Akt phosphorylation in cardiomyocytes.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
26498639-0	2015	Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-alpha/ERK1/2 pathway: An in vitro investigation.	7,3'-dihydroxy-4'-methoxyisoflavone	57-66	protein kinase C alpha	Homo sapiens	89-98
26690415-0	2015	Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-kappaB.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	TNF superfamily member 11	Homo sapiens	21-26
26690415-2	2015	In this study, we examined the effects of calycosin on osteoclastogenesis induced by RANKL.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	TNF superfamily member 11	Homo sapiens	85-90
26690415-3	2015	The results showed that calycosin significantly inhibited RANKL-induced osteoclast formation from primary bone marrow macrophages (BMMs).	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	TNF superfamily member 11	Homo sapiens	58-63
26690415-5	2015	In addition, the expression of osteoclatogenesis-related genes, including cathepsin K (CtsK), tartrate-resistant acid phosphatase (TRAP), and MMP-9, was significantly inhibited by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	180-189	cathepsin K	Homo sapiens	74-85
26690415-5	2015	In addition, the expression of osteoclatogenesis-related genes, including cathepsin K (CtsK), tartrate-resistant acid phosphatase (TRAP), and MMP-9, was significantly inhibited by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	180-189	cathepsin K	Homo sapiens	87-91
26690415-5	2015	In addition, the expression of osteoclatogenesis-related genes, including cathepsin K (CtsK), tartrate-resistant acid phosphatase (TRAP), and MMP-9, was significantly inhibited by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	180-189	matrix metallopeptidase 9	Homo sapiens	142-147
26498639-0	2015	Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-alpha/ERK1/2 pathway: An in vitro investigation.	7,3'-dihydroxy-4'-methoxyisoflavone	57-66	mitogen-activated protein kinase 3	Homo sapiens	99-105
26498639-3	2015	Calycosin (Cal), an effector chemical from Astragalus has been reported to affect the recurrence and metastasis of cancer cells via the regulation of the protein expression of matrix metalloproteinases (MMPs).	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 2	Homo sapiens	203-207
26498639-3	2015	Calycosin (Cal), an effector chemical from Astragalus has been reported to affect the recurrence and metastasis of cancer cells via the regulation of the protein expression of matrix metalloproteinases (MMPs).	7,3'-dihydroxy-4'-methoxyisoflavone	0-3	matrix metallopeptidase 2	Homo sapiens	203-207
25450186-2	2015	METHODS: The effects of VEGFR1/2 kinase inhibitor (VRI) and calycosin on Flt1 tyrosine kinase (TK) activity were evaluated by molecular docking, enzymatic inhibition assay, protein co-immunoprecipitation and siRNA gene knock-down analysis in HUVECs.	7,3'-dihydroxy-4'-methoxyisoflavone	60-69	fms related receptor tyrosine kinase 1	Danio rerio	73-77
26215320-0	2015	Calycosin induces apoptosis by the regulation of ERbeta/miR-17 signaling pathway in human colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	microRNA 17	Homo sapiens	56-62
26215320-2	2015	Calycosin, a main component of isoflavones, has been shown to suppress the growth of hormone-dependent tumors through an ERbeta-mediated signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 2	Homo sapiens	121-127
26215320-10	2015	In addition, ERbeta expression significantly increased in calycosin-treated HCT-116 cells, followed by a decrease of miR-17, and up-regulation of PTEN.	7,3'-dihydroxy-4'-methoxyisoflavone	58-67	estrogen receptor 2	Homo sapiens	13-19
26215320-11	2015	Our results indicate that calycosin has an inhibitory effect on CRC, which might be obtained by ERbeta-mediated regulation of miR-17 and PTEN expression.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	estrogen receptor 2	Homo sapiens	96-102
26215320-11	2015	Our results indicate that calycosin has an inhibitory effect on CRC, which might be obtained by ERbeta-mediated regulation of miR-17 and PTEN expression.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	microRNA 17	Homo sapiens	126-132
26215320-11	2015	Our results indicate that calycosin has an inhibitory effect on CRC, which might be obtained by ERbeta-mediated regulation of miR-17 and PTEN expression.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	phosphatase and tensin homolog	Homo sapiens	137-141
26591530-0	2015	[Study on inhibitory effect of calycosin on hepatic stellate cell activation in rats by up-regulating peroxisome proliferator-activated receptor gamma].	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	102-150
26591530-1	2015	To observe the effect of calycosin on the proliferation and activation of primary hepatic stellate cells (HSCs) in rats, and prove calycosin shows the effects through peroxisome proliferator-activated receptor gamma(PPARgamma) and farnesoid X receptor (FXR).	7,3'-dihydroxy-4'-methoxyisoflavone	131-140	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	167-215
26591530-1	2015	To observe the effect of calycosin on the proliferation and activation of primary hepatic stellate cells (HSCs) in rats, and prove calycosin shows the effects through peroxisome proliferator-activated receptor gamma(PPARgamma) and farnesoid X receptor (FXR).	7,3'-dihydroxy-4'-methoxyisoflavone	131-140	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	216-225
26591530-1	2015	To observe the effect of calycosin on the proliferation and activation of primary hepatic stellate cells (HSCs) in rats, and prove calycosin shows the effects through peroxisome proliferator-activated receptor gamma(PPARgamma) and farnesoid X receptor (FXR).	7,3'-dihydroxy-4'-methoxyisoflavone	131-140	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	253-256
26591530-4	2015	Calycosin could up-regulate PPARgamma expression and its nuclear transition in a concentration-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	28-37
26591530-6	2015	In conclusion, calycosin could inhibit HSC activation and proliferation, which may be related with the up-regulation of PPARgamma signal pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	120-129
26215320-0	2015	Calycosin induces apoptosis by the regulation of ERbeta/miR-17 signaling pathway in human colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 2	Homo sapiens	49-55
25672608-0	2015	Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	BCL2 apoptosis regulator	Homo sapiens	91-96
25672608-10	2015	In summary, calycosin might exert anti-growth and induce-apoptosis activity against ovarian cancer SKOV3 cells through activating caspases and Bcl-2 family proteins, therefore presenting as a promising therapeutic agent for the treatment of ovarian cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	BCL2 apoptosis regulator	Homo sapiens	143-148
25975048-8	2015	The expression of VEGF and CD31 showed a dose-dependent manner when calycosin was administrated.	7,3'-dihydroxy-4'-methoxyisoflavone	68-77	vascular endothelial growth factor A	Rattus norvegicus	18-22
25975048-9	2015	The calycosin-treated (4 mg/kg) group displayed a two-fold increase in VEGF expression at both the mRNA and protein levels compared with the DMSO group.	7,3'-dihydroxy-4'-methoxyisoflavone	4-13	vascular endothelial growth factor A	Rattus norvegicus	71-75
25975048-11	2015	CONCLUSION: Calycosin improved left ventricular ejection fraction in the MI rat models, induced VEGF expression in the ischaemic myocardium, increased CD31 expression and promoted angiogenesis.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	vascular endothelial growth factor A	Rattus norvegicus	96-100
25450186-9	2015	Docking and kinase inhibition assay revealed that calycosin competed with VRI for the tyrosine kinase domain of Flt1 without affecting ATP binding.	7,3'-dihydroxy-4'-methoxyisoflavone	50-59	fms related receptor tyrosine kinase 1	Danio rerio	112-116
25450186-11	2015	Consistent with these results, calycosin counteracted the inhibition of Flt1-TK and PI3K phosphorylation induced by VRI in HUVECs.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	fms related receptor tyrosine kinase 1	Danio rerio	72-76
25450186-13	2015	The impeding effect of calycosin on VRI-induced blood vessel loss was absent in zebrafish embryos injected with Flt1 MO.	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	fms related receptor tyrosine kinase 1	Danio rerio	112-116
26265982-0	2015	Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	prostaglandin reductase 1	Homo sapiens	189-227
25143196-0	2015	Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	22-31	chemokine (C-C motif) ligand 4	Mus musculus	40-44
25143196-0	2015	Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	22-31	nuclear receptor subfamily 1, group H, member 4	Mus musculus	85-88
25143196-0	2015	Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	22-31	signal transducer and activator of transcription 3	Mus musculus	93-98
25143196-1	2015	PURPOSE: Investigating the hepatoprotective effect of calycosin against acute liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	nuclear receptor subfamily 1, group H, member 4	Mus musculus	111-114
25143196-1	2015	PURPOSE: Investigating the hepatoprotective effect of calycosin against acute liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	signal transducer and activator of transcription 3	Mus musculus	130-135
25143196-5	2015	The relation between calycosin and activation of FXR and STAT3 was comfirmed using the Luciferase assay, Molecular docking, Real-time PCR and Western Blot in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	nuclear receptor subfamily 1, group H, member 4	Mus musculus	49-52
25143196-5	2015	The relation between calycosin and activation of FXR and STAT3 was comfirmed using the Luciferase assay, Molecular docking, Real-time PCR and Western Blot in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	signal transducer and activator of transcription 3	Mus musculus	57-62
25143196-7	2015	Calycosin promoted the expression of FXR target genes such as FoxM1B and SHP but the effect was reversed by FXR suppressor guggulsterone.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear receptor subfamily 1, group H, member 4	Mus musculus	37-40
25143196-7	2015	Calycosin promoted the expression of FXR target genes such as FoxM1B and SHP but the effect was reversed by FXR suppressor guggulsterone.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	forkhead box M1	Mus musculus	62-68
25423498-1	2015	AIM: The aim of this paper was to compare the efficacy of in vitro calycosin and irbesartan for the treatment of angiotensin II (AngII)-induced renin angiotensin system (RAS) disorder in human umbilical vein endothelial cells (HUVECs).	7,3'-dihydroxy-4'-methoxyisoflavone	67-76	angiotensinogen	Homo sapiens	113-127
25423498-1	2015	AIM: The aim of this paper was to compare the efficacy of in vitro calycosin and irbesartan for the treatment of angiotensin II (AngII)-induced renin angiotensin system (RAS) disorder in human umbilical vein endothelial cells (HUVECs).	7,3'-dihydroxy-4'-methoxyisoflavone	67-76	angiotensinogen	Homo sapiens	129-134
25423498-6	2015	Interestingly, Calycosin was able to inhibit the effect of AngII in a concentration dependent manner, and its effect at concentration of 35 mumol was equal to that of positive control Irbesartan (10mumol).	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	angiotensinogen	Homo sapiens	59-64
25423498-7	2015	CONCLUSION: Calycosin from Radix Astragali from Gansu province could protect HUVECs from AngII induced RAS disorder by downregulation of ACE expression and increased ACE2 expression, which is similar to irbesartan.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	angiotensinogen	Homo sapiens	89-94
25423498-7	2015	CONCLUSION: Calycosin from Radix Astragali from Gansu province could protect HUVECs from AngII induced RAS disorder by downregulation of ACE expression and increased ACE2 expression, which is similar to irbesartan.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	angiotensin I converting enzyme	Homo sapiens	137-140
25423498-7	2015	CONCLUSION: Calycosin from Radix Astragali from Gansu province could protect HUVECs from AngII induced RAS disorder by downregulation of ACE expression and increased ACE2 expression, which is similar to irbesartan.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	angiotensin converting enzyme 2	Homo sapiens	166-170
25143196-7	2015	Calycosin promoted the expression of FXR target genes such as FoxM1B and SHP but the effect was reversed by FXR suppressor guggulsterone.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear receptor subfamily 0, group B, member 2	Mus musculus	73-76
25143196-7	2015	Calycosin promoted the expression of FXR target genes such as FoxM1B and SHP but the effect was reversed by FXR suppressor guggulsterone.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nuclear receptor subfamily 1, group H, member 4	Mus musculus	108-111
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	nuclear receptor subfamily 1, group H, member 4	Mus musculus	96-99
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	signal transducer and activator of transcription 3	Mus musculus	139-144
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	BCL2-like 1	Mus musculus	192-198
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	suppressor of cytokine signaling 3	Mus musculus	203-208
25143196-9	2015	CONCLUSIONS: Calycosin plays a critical role in hepatoprotection against liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	nuclear receptor subfamily 1, group H, member 4	Mus musculus	106-109
25143196-9	2015	CONCLUSIONS: Calycosin plays a critical role in hepatoprotection against liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	125-130
25613518-0	2015	Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	HOX transcript antisense RNA	Homo sapiens	60-66
25613518-0	2015	Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	69-72
25613518-9	2015	Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	AKT serine/threonine kinase 1	Homo sapiens	94-97
25613518-9	2015	Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	HOX transcript antisense RNA	Homo sapiens	150-156
25613518-10	2015	CONCLUSION: Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	AKT serine/threonine kinase 1	Homo sapiens	131-134
25613518-10	2015	CONCLUSION: Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	HOX transcript antisense RNA	Homo sapiens	158-164
26265982-7	2015	We confirmed that gallic acid and commercial calycosin or formononetin could synergistically induce LTB4DH expression in HepG2 cells and human neutrophils.	7,3'-dihydroxy-4'-methoxyisoflavone	45-54	prostaglandin reductase 1	Homo sapiens	100-106
26265982-10	2015	Calycosin and gallic acid dramatically suppressed isoproterenol-induced increase in myeloperoxidase (MPO) activity and malondialdehyde (MDA) level.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	myeloperoxidase	Homo sapiens	84-99
26265982-10	2015	Calycosin and gallic acid dramatically suppressed isoproterenol-induced increase in myeloperoxidase (MPO) activity and malondialdehyde (MDA) level.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	myeloperoxidase	Homo sapiens	101-104
26265982-11	2015	Collectively, our results suggest that LTB4DH inducers (i.e., calycosin and gallic acid) may be a novel combined therapy for the treatment of neutrophil-mediated myocardial injury.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	prostaglandin reductase 1	Homo sapiens	39-45
26265982-6	2015	By evaluating LTB4DH induction, we identified calycosin and formononetin from Radix Astragali by HPLC-ESI-MS technique.	7,3'-dihydroxy-4'-methoxyisoflavone	46-55	prostaglandin reductase 1	Homo sapiens	14-20
24548484-0	2014	Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats.	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	ras related dexamethasone induced 1	Rattus norvegicus	14-19
24797937-5	2014	In addition, calycosin effectively down-regulated cellular mRNA expressions of IkappaBalpha, NF-kappaB p65 and cyclin D1 through RT-PCR assay (P<0.01).	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	NFKB inhibitor alpha	Homo sapiens	79-91
24797937-5	2014	In addition, calycosin effectively down-regulated cellular mRNA expressions of IkappaBalpha, NF-kappaB p65 and cyclin D1 through RT-PCR assay (P<0.01).	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	93-106
24797937-5	2014	In addition, calycosin effectively down-regulated cellular mRNA expressions of IkappaBalpha, NF-kappaB p65 and cyclin D1 through RT-PCR assay (P<0.01).	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	cyclin D1	Homo sapiens	111-120
25044472-7	2014	UGT1A1, 1A3 and 1A10 showed activities on both 3"-OH and 7-OH, whereas UGT1A7, 1A8, 1A9, and 2B7 were only capable of catalyzing 3"-OH glucuronidation of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	154-163	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
25044472-7	2014	UGT1A1, 1A3 and 1A10 showed activities on both 3"-OH and 7-OH, whereas UGT1A7, 1A8, 1A9, and 2B7 were only capable of catalyzing 3"-OH glucuronidation of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	154-163	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	71-77
25044472-11	2014	These findings demonstrated the regioselective glucuronidation at the 3"-OH of the isoflavone calycosin in HLMs and shed light on potential drug interactions of calycosin with other UGT1A9 substrates.	7,3'-dihydroxy-4'-methoxyisoflavone	94-103	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	182-188
25044472-11	2014	These findings demonstrated the regioselective glucuronidation at the 3"-OH of the isoflavone calycosin in HLMs and shed light on potential drug interactions of calycosin with other UGT1A9 substrates.	7,3'-dihydroxy-4'-methoxyisoflavone	161-170	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	182-188
24548484-0	2014	Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats.	7,3'-dihydroxy-4'-methoxyisoflavone	82-91	microRNA 375	Rattus norvegicus	36-43
24548484-6	2014	To provide insight into the functions of estrogen receptor (ER)-mediated signaling pathway in neuroprotection by calycosin, the expression of miR-375, ER-alpha, RASD1 (Dexamethasone-induced Ras-related protein 1) and Bcl-2 was determined by RT-PCR or western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	113-122	ras related dexamethasone induced 1	Rattus norvegicus	168-211
24548484-7	2014	Calycosin exhibited a downregulation of RASD1, and an upregulation of ER-alpha, miR-375 and Bcl-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	ras related dexamethasone induced 1	Rattus norvegicus	40-45
24548484-7	2014	Calycosin exhibited a downregulation of RASD1, and an upregulation of ER-alpha, miR-375 and Bcl-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Rattus norvegicus	70-78
24548484-7	2014	Calycosin exhibited a downregulation of RASD1, and an upregulation of ER-alpha, miR-375 and Bcl-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	microRNA 375	Rattus norvegicus	80-87
24548484-7	2014	Calycosin exhibited a downregulation of RASD1, and an upregulation of ER-alpha, miR-375 and Bcl-2.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	BCL2, apoptosis regulator	Rattus norvegicus	92-97
24548484-8	2014	Our finding illustrated that calycosin had been shown neuroprotective effects in cerebral ischemia/reperfusion rats, and the molecular mechanisms may correlate with the positive feedback between ER-alpha and miR-375, along with the regulation of downstream targets.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	estrogen receptor 1	Rattus norvegicus	195-203
24548484-8	2014	Our finding illustrated that calycosin had been shown neuroprotective effects in cerebral ischemia/reperfusion rats, and the molecular mechanisms may correlate with the positive feedback between ER-alpha and miR-375, along with the regulation of downstream targets.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	microRNA 375	Rattus norvegicus	208-215
23417504-0	2013	Calycosin and formononetin from astragalus root enhance dimethylarginine dimethylaminohydrolase 2 and nitric oxide synthase expressions in Madin Darby Canine Kidney II cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	dimethylarginine dimethylaminohydrolase 2	Canis lupus familiaris	56-97
23797737-7	2014	Further studies found that pre-incubation with calycosin at 1 x 10(-8) M dramatically increased anti-apoptotic Bcl-2 while decreased pro-apoptotic Bax and Bad expressions as detected by immunocytochemistry, and the effect of calycosin on rebalancing the ratio of Bcl-2/Bax was more significant than that of its glycoside, calycosin-7-O-beta-D-glucopyranoside (CG).	7,3'-dihydroxy-4'-methoxyisoflavone	47-56	BCL2 apoptosis regulator	Homo sapiens	111-116
23797737-7	2014	Further studies found that pre-incubation with calycosin at 1 x 10(-8) M dramatically increased anti-apoptotic Bcl-2 while decreased pro-apoptotic Bax and Bad expressions as detected by immunocytochemistry, and the effect of calycosin on rebalancing the ratio of Bcl-2/Bax was more significant than that of its glycoside, calycosin-7-O-beta-D-glucopyranoside (CG).	7,3'-dihydroxy-4'-methoxyisoflavone	47-56	BCL2 apoptosis regulator	Homo sapiens	263-268
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 2	Homo sapiens	51-57
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	insulin like growth factor 1 receptor	Homo sapiens	82-88
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 1	Homo sapiens	90-93
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 3	Homo sapiens	94-98
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	108-111
24618835-1	2014	We previously reported that calycosin, a natural phytoestrogen structurally similar to estrogen, successfully triggered apoptosis of estrogen receptor (ER)-positive breast cancer cell line, MCF-7.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	estrogen receptor 1	Homo sapiens	133-150
24618835-1	2014	We previously reported that calycosin, a natural phytoestrogen structurally similar to estrogen, successfully triggered apoptosis of estrogen receptor (ER)-positive breast cancer cell line, MCF-7.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	estrogen receptor 1	Homo sapiens	152-154
24618835-3	2014	Notably, calycosin led to inhibited cell proliferation and apoptosis only in ER-positive cells, particularly in MCF-7 cells, whereas no such effect was observed in ER-negative cells.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	estrogen receptor 1	Homo sapiens	77-79
24618835-4	2014	Then we investigated whether regulation of ERbeta, a subtype of ER, contributed to calycosin-induced apoptosis in breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	83-92	estrogen receptor 2	Homo sapiens	43-49
24618835-5	2014	The results showed that incubation of calycosin resulted in enhanced expression ERbeta in MCF-7 and T-47D cells, rather than MDA-231 and MDA-435 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	estrogen receptor 2	Homo sapiens	80-86
24618835-7	2014	However, the other two members of the mitogen-activated protein kinase (MAPK) family, extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK), were not consequently regulated by downregulated IGF-1R, indicating ERK 1/2 and JNK pathways were not necessary to allow proliferation inhibition by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	318-327	mitogen-activated protein kinase 3	Homo sapiens	72-76
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	estrogen receptor 1	Homo sapiens	100-102
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	estrogen receptor 2	Homo sapiens	154-160
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	insulin like growth factor 1 receptor	Homo sapiens	183-189
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	mitogen-activated protein kinase 3	Homo sapiens	230-234
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	AKT serine/threonine kinase 1	Homo sapiens	276-279
24991562-7	2014	The TCM candidate compound, calycosin, has potent binding affinity with IL6R protein.	7,3'-dihydroxy-4'-methoxyisoflavone	28-37	interleukin 6 receptor	Homo sapiens	72-76
24991562-11	2014	Therefore, calycosin is a potential candidate as lead compounds for further study in drug development process with IL6R protein against rheumatoid arthritis.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	interleukin 6 receptor	Homo sapiens	115-119
25170541-2	2014	In view of the expression of ER in human osteosarcoma cells, the purpose of this study is to investigate whether formononetin and calycosin, two of the major isoflavones in Radix astragali, could also elicit anti-tumor activity against osteosarcoma, along with the underlying mechanism.	7,3'-dihydroxy-4'-methoxyisoflavone	130-139	estrogen receptor 1	Homo sapiens	29-31
23417504-0	2013	Calycosin and formononetin from astragalus root enhance dimethylarginine dimethylaminohydrolase 2 and nitric oxide synthase expressions in Madin Darby Canine Kidney II cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	nitric oxide synthase 3	Canis lupus familiaris	102-123
23417504-5	2013	We isolated two isoflavones, calycosin and formononetin from astragalus root, one of the components of SKT, which can promote DDAH2 protein and mRNA expressions in MDCK II cells.	7,3'-dihydroxy-4'-methoxyisoflavone	29-38	dimethylarginine dimethylaminohydrolase 2	Canis lupus familiaris	126-131
24355881-0	2013	Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calycosin and formononetin.	7,3'-dihydroxy-4'-methoxyisoflavone	97-106	estrogen receptor 2	Homo sapiens	0-22
23609007-0	2013	Calycosin induces apoptosis by upregulation of RASD1 in human breast cancer cells MCF-7.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	ras related dexamethasone induced 1	Homo sapiens	47-52
23609007-7	2013	To provide insight into the functions of RASD1 signaling pathway in calycosin-induced apoptosis, the expression of Bcl-2, Bax, and RASD1 in calycosin-treated cells were determined by Western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	68-77	ras related dexamethasone induced 1	Homo sapiens	41-46
23609007-7	2013	To provide insight into the functions of RASD1 signaling pathway in calycosin-induced apoptosis, the expression of Bcl-2, Bax, and RASD1 in calycosin-treated cells were determined by Western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	140-149	ras related dexamethasone induced 1	Homo sapiens	41-46
23609007-7	2013	To provide insight into the functions of RASD1 signaling pathway in calycosin-induced apoptosis, the expression of Bcl-2, Bax, and RASD1 in calycosin-treated cells were determined by Western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	140-149	BCL2 apoptosis regulator	Homo sapiens	115-120
23609007-7	2013	To provide insight into the functions of RASD1 signaling pathway in calycosin-induced apoptosis, the expression of Bcl-2, Bax, and RASD1 in calycosin-treated cells were determined by Western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	140-149	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
23609007-7	2013	To provide insight into the functions of RASD1 signaling pathway in calycosin-induced apoptosis, the expression of Bcl-2, Bax, and RASD1 in calycosin-treated cells were determined by Western blot assay.	7,3'-dihydroxy-4'-methoxyisoflavone	140-149	ras related dexamethasone induced 1	Homo sapiens	131-136
23609007-9	2013	Moreover, compared with control group, the expression of Bcl-2 decreased with calycosin in MCF-7 cells, while Bax increased, which was significantly correlated with elevated expression of RASD1.	7,3'-dihydroxy-4'-methoxyisoflavone	78-87	BCL2 apoptosis regulator	Homo sapiens	57-62
23609007-10	2013	Together, we present evidence that at relatively high concentration calycosin triggered cell apoptosis through the mitochondrial apoptotic pathway by upregulating RASD1.	7,3'-dihydroxy-4'-methoxyisoflavone	68-77	ras related dexamethasone induced 1	Homo sapiens	163-168
24355881-11	2013	After the treatment of calycosin, ERbeta expression was significantly increased in MCF-7 cells, followed by decrease of IGF-1R, activation of PARP-1 cleavage and downregulation of miR-375.	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	estrogen receptor 2	Homo sapiens	34-40
24355881-11	2013	After the treatment of calycosin, ERbeta expression was significantly increased in MCF-7 cells, followed by decrease of IGF-1R, activation of PARP-1 cleavage and downregulation of miR-375.	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	insulin like growth factor 1 receptor	Homo sapiens	120-126
24355881-11	2013	After the treatment of calycosin, ERbeta expression was significantly increased in MCF-7 cells, followed by decrease of IGF-1R, activation of PARP-1 cleavage and downregulation of miR-375.	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	poly(ADP-ribose) polymerase 1	Homo sapiens	142-148
24355881-11	2013	After the treatment of calycosin, ERbeta expression was significantly increased in MCF-7 cells, followed by decrease of IGF-1R, activation of PARP-1 cleavage and downregulation of miR-375.	7,3'-dihydroxy-4'-methoxyisoflavone	23-32	microRNA 375	Homo sapiens	180-187
24355881-12	2013	CONCLUSION: Calycosin has an advantage on inhibiting breast cancer growth in comparison with formononetin, which is obtained by ERbeta-mediated regulation of IGF-1R signaling pathways and miR-375 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	estrogen receptor 2	Homo sapiens	128-134
24355881-12	2013	CONCLUSION: Calycosin has an advantage on inhibiting breast cancer growth in comparison with formononetin, which is obtained by ERbeta-mediated regulation of IGF-1R signaling pathways and miR-375 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	insulin like growth factor 1 receptor	Homo sapiens	158-164
24355881-12	2013	CONCLUSION: Calycosin has an advantage on inhibiting breast cancer growth in comparison with formononetin, which is obtained by ERbeta-mediated regulation of IGF-1R signaling pathways and miR-375 expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	microRNA 375	Homo sapiens	188-195
23878590-6	2013	Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF).	7,3'-dihydroxy-4'-methoxyisoflavone	59-68	brain-derived neurotrophic factor	Rattus norvegicus	292-325
23878590-6	2013	Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF).	7,3'-dihydroxy-4'-methoxyisoflavone	59-68	brain-derived neurotrophic factor	Rattus norvegicus	327-331
22848779-7	2012	The level of cyclin D1 mRNA in K562 cells decreased after the treatment with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	85-94	cyclin D1	Homo sapiens	13-22
23878590-6	2013	Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF).	7,3'-dihydroxy-4'-methoxyisoflavone	59-68	glial cell derived neurotrophic factor	Rattus norvegicus	246-279
23878590-6	2013	Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF).	7,3'-dihydroxy-4'-methoxyisoflavone	59-68	glial cell derived neurotrophic factor	Rattus norvegicus	281-285
23123262-6	2012	Calycosin also reduced the content of malondialdehyde (MDA), protein carbonyl and reactive oxygen species (ROS), and up-regulated the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	catalase	Rattus norvegicus	176-184
21909574-5	2011	Our findings using transcriptional profiling by deep sequencing, and confirmed by quantitative real-time PCR (qPCR), demonstrate that calycosin modulated vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and ErbB signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	134-143	vascular endothelial growth factor Aa	Danio rerio	190-194
22368866-5	2011	RT-PCR was used to determine the level of Cyclin D1 mRNA in K562 cells after treated with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	98-107	cyclin D1	Homo sapiens	42-51
22368866-8	2011	The level of Cyclin D1 mRNA in K562 cells decreased after treated with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	cyclin D1	Homo sapiens	13-22
21799188-0	2011	Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Homo sapiens	38-55
21799188-0	2011	Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
21799188-0	2011	Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	BCL2 apoptosis regulator	Homo sapiens	157-162
21799188-3	2011	This study investigated the effects and mechanisms of calycosin on estrogen receptor (ER)-positive human breast cancer (MCF-7) cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	estrogen receptor 1	Homo sapiens	67-84
21799188-3	2011	This study investigated the effects and mechanisms of calycosin on estrogen receptor (ER)-positive human breast cancer (MCF-7) cells in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	estrogen receptor 1	Homo sapiens	86-88
21799188-4	2011	METHODS: ER-positive MCF-7 cells were treated with different concentrations of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	estrogen receptor 1	Homo sapiens	9-11
21799188-5	2011	Effects of calycosin on the proliferation of ER-positive MCF-7 cells were determined by the MTT assay.	7,3'-dihydroxy-4'-methoxyisoflavone	11-20	estrogen receptor 1	Homo sapiens	45-47
21799188-8	2011	RESULTS: Compared with the vehicle control, calycosin stimulated proliferation of ER-positive MCF-7 cells at low concentrations (2, 4, and 8 micromol/L).	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	estrogen receptor 1	Homo sapiens	82-84
21799188-9	2011	Furthermore, at these concentrations, calycosin decreased the percentage of early apoptosis in MCF-7 cells, downregulated mRNA and protein levels of Bax, and upregulated those of Bcl-2 at low concentrations.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
21799188-9	2011	Furthermore, at these concentrations, calycosin decreased the percentage of early apoptosis in MCF-7 cells, downregulated mRNA and protein levels of Bax, and upregulated those of Bcl-2 at low concentrations.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	BCL2 apoptosis regulator	Homo sapiens	179-184
21909574-6	2011	The inhibitory effects of calycosin-induced phenotypic responses by several pathway-specific inhibitors (VRI, SU5402, MEK1/2 Inhibitor, Wortmannin and LY294002) further identified the potential involvement of VEGF(R) and FGF(R) signaling pathways in the angiogenic activities of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	26-35	vascular endothelial growth factor Aa	Danio rerio	209-213
34186122-5	2021	ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	154-163
21612861-0	2011	Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	estrogen receptor 1	Homo sapiens	36-53
21612861-0	2011	Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 3	Homo sapiens	96-102
21612861-3	2011	This study was a continuation of our investigations of calycosin"s promotion of the proliferation of estrogen receptor (ER)-positive cells via ERs and ERK1/2 activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	55-64	estrogen receptor 1	Homo sapiens	101-118
21612861-3	2011	This study was a continuation of our investigations of calycosin"s promotion of the proliferation of estrogen receptor (ER)-positive cells via ERs and ERK1/2 activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	55-64	estrogen receptor 1	Homo sapiens	120-122
21612861-3	2011	This study was a continuation of our investigations of calycosin"s promotion of the proliferation of estrogen receptor (ER)-positive cells via ERs and ERK1/2 activation in vitro and in vivo.	7,3'-dihydroxy-4'-methoxyisoflavone	55-64	mitogen-activated protein kinase 3	Homo sapiens	151-157
21612861-4	2011	ER-positive MCF-7 (human breast cancer) cells were treated with different concentrations of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	92-101	estrogen receptor 1	Homo sapiens	0-2
21612861-11	2011	Furthermore, we found that an ERK1/2 inhibitor significantly blocked the effect of calycosin in MCF-7 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	83-92	mitogen-activated protein kinase 3	Homo sapiens	30-36
21612861-12	2011	In the in vivo studies, calycosin stimulated a dramatic increase in uterine weight and downregulated the level of ERalpha protein in OVX mice.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	estrogen receptor 1 (alpha)	Mus musculus	114-121
21669275-9	2011	Pre-treatment with calycosin strikingly down-regulated HUVEC TGF-beta1, ICAM-1 and RAGE expressions in both protein and mRNA levels.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	transforming growth factor beta 1	Homo sapiens	61-70
21669275-9	2011	Pre-treatment with calycosin strikingly down-regulated HUVEC TGF-beta1, ICAM-1 and RAGE expressions in both protein and mRNA levels.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	intercellular adhesion molecule 1	Homo sapiens	72-78
21669275-9	2011	Pre-treatment with calycosin strikingly down-regulated HUVEC TGF-beta1, ICAM-1 and RAGE expressions in both protein and mRNA levels.	7,3'-dihydroxy-4'-methoxyisoflavone	19-28	long intergenic non-protein coding RNA 914	Homo sapiens	83-87
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	estrogen receptor 1	Homo sapiens	58-75
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	mitogen-activated protein kinase 3	Homo sapiens	113-119
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	nuclear factor kappa B subunit 1	Homo sapiens	124-133
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	estrogen receptor 1	Homo sapiens	237-254
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	205-214	estrogen receptor 1	Homo sapiens	58-75
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	205-214	mitogen-activated protein kinase 3	Homo sapiens	113-119
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	205-214	nuclear factor kappa B subunit 1	Homo sapiens	124-133
21669275-10	2011	Furthermore, calycosin incubation significantly increased estrogen receptor expression and reversed AGEs-induced ERK1/2 and NF-kappaB phosphorylation and nuclear translocation in HUVEC, and this effect of calycosin could be inhibited by estrogen receptor inhibitor, ICI182780.	7,3'-dihydroxy-4'-methoxyisoflavone	205-214	estrogen receptor 1	Homo sapiens	237-254
20686605-0	2010	Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 1	Danio rerio	98-102
20686605-10	2010	The role of MAPK signaling in calycosin-induced angiogenesis was evaluated using western blotting.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	mitogen-activated protein kinase 1	Danio rerio	12-16
20686605-11	2010	CONCLUSION: Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	vascular endothelial growth factor Aa	Danio rerio	177-211
20686605-11	2010	CONCLUSION: Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	vascular endothelial growth factor Aa	Danio rerio	213-217
20686605-11	2010	CONCLUSION: Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	fms related receptor tyrosine kinase 1	Danio rerio	220-226
20686605-11	2010	CONCLUSION: Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	kinase insert domain receptor like	Danio rerio	231-237
20686605-13	2010	Our results further indicated that calycosin promotes angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER.	7,3'-dihydroxy-4'-methoxyisoflavone	35-44	mitogen-activated protein kinase 1	Danio rerio	85-89
20686605-13	2010	Our results further indicated that calycosin promotes angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER.	7,3'-dihydroxy-4'-methoxyisoflavone	35-44	mitogen-activated protein kinase 3	Danio rerio	114-120
20686605-14	2010	Together, this study revealed, for the first time, that calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	vascular endothelial growth factor Aa	Danio rerio	171-175
20686605-14	2010	Together, this study revealed, for the first time, that calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	kinase insert domain receptor like	Danio rerio	176-182
20686605-14	2010	Together, this study revealed, for the first time, that calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	mitogen-activated protein kinase 1	Danio rerio	187-191
15810591-3	2004	CFP was referenced to formononetin, calycosin and then the contents of astragaloside IV, formononetin and calycosin was determinted.	7,3'-dihydroxy-4'-methoxyisoflavone	36-45	complement factor properdin	Homo sapiens	0-3
15810591-3	2004	CFP was referenced to formononetin, calycosin and then the contents of astragaloside IV, formononetin and calycosin was determinted.	7,3'-dihydroxy-4'-methoxyisoflavone	106-115	complement factor properdin	Homo sapiens	0-3
33798579-0	2021	Antioxidant activity of calycosin against alpha-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson"s disease.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	synuclein alpha	Homo sapiens	42-57
33798579-2	2021	In the present study, the anti-fibrillation activity of calycosin and its influence on the kinetics of amyloid formation of alpha-synuclein (alpha-syn) and associated cytotoxicity on neuron-like cells (PC-12) as a model of Parkinson"s disease were explored.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	synuclein alpha	Homo sapiens	124-139
33798579-2	2021	In the present study, the anti-fibrillation activity of calycosin and its influence on the kinetics of amyloid formation of alpha-synuclein (alpha-syn) and associated cytotoxicity on neuron-like cells (PC-12) as a model of Parkinson"s disease were explored.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	synuclein alpha	Homo sapiens	124-133
34713437-0	2022	Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apoE-/- mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Kruppel-like factor 2 (lung)	Mus musculus	100-104
34713437-0	2022	Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apoE-/- mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mixed lineage kinase domain-like	Mus musculus	109-113
34713437-0	2022	Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apoE-/- mice.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	apolipoprotein E	Mus musculus	117-121
34713437-12	2022	Mechanistically, inhibitory effects of calycosin on atherogenesis were via improving autophagy through modulating KLF2-MLKL signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	Kruppel-like factor 2 (lung)	Mus musculus	114-118
34713437-12	2022	Mechanistically, inhibitory effects of calycosin on atherogenesis were via improving autophagy through modulating KLF2-MLKL signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	mixed lineage kinase domain-like	Mus musculus	119-123
34713437-13	2022	CONCLUSIONS AND IMPLICATIONS: This study demonstrated the atheroprotective effect of calycosin was through upregulating KLF2-MLKL-mediated autophagy, which not only proposed novel mechanistic insights into the atherogenesis but also identified calycosin as a potential drug candidate for atherosclerosis treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	85-94	Kruppel-like factor 2 (lung)	Mus musculus	120-124
34713437-13	2022	CONCLUSIONS AND IMPLICATIONS: This study demonstrated the atheroprotective effect of calycosin was through upregulating KLF2-MLKL-mediated autophagy, which not only proposed novel mechanistic insights into the atherogenesis but also identified calycosin as a potential drug candidate for atherosclerosis treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	85-94	mixed lineage kinase domain-like	Mus musculus	125-129
34713437-13	2022	CONCLUSIONS AND IMPLICATIONS: This study demonstrated the atheroprotective effect of calycosin was through upregulating KLF2-MLKL-mediated autophagy, which not only proposed novel mechanistic insights into the atherogenesis but also identified calycosin as a potential drug candidate for atherosclerosis treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	244-253	Kruppel-like factor 2 (lung)	Mus musculus	120-124
34713437-13	2022	CONCLUSIONS AND IMPLICATIONS: This study demonstrated the atheroprotective effect of calycosin was through upregulating KLF2-MLKL-mediated autophagy, which not only proposed novel mechanistic insights into the atherogenesis but also identified calycosin as a potential drug candidate for atherosclerosis treatment.	7,3'-dihydroxy-4'-methoxyisoflavone	244-253	mixed lineage kinase domain-like	Mus musculus	125-129
34908806-15	2021	CONCLUSION: Cal protects mice against L-arg-induced SAP and associated ALI by attenuating local and systemic neutrophil infiltration and inflammatory response via inhibition of HGMB1 and the NF-kappaB signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	12-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	191-200
34186122-0	2021	Enhancement of interferon gamma stability as an anticancer therapeutic protein against hepatocellular carcinoma upon interaction with calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	134-143	interferon gamma	Homo sapiens	15-31
34186122-2	2021	Herein, we explored the thermodynamic parameters and conformational stability of IFN-gamma in the presence of calycosin, the main active compound of Radix astragali, by different biophysical and theoretical analysis.	7,3'-dihydroxy-4'-methoxyisoflavone	110-119	interferon gamma	Homo sapiens	81-90
34186122-4	2021	ITC data indicated that upon interaction of calycosin with IFN-gamma the binding and thermodynamic parameters were as follows: Kd = 1.9 muM, DeltaG  = -32.45 kJ/mol, DeltaH  = -11.91 kJ/mol, and TDeltaS  = 20.54 kJ/mol.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	interferon gamma	Homo sapiens	59-68
34186122-5	2021	ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	118-127
21669275-11	2011	CONCLUSIONS: These findings suggest that calycosin can reduce AGEs-induced macrophage migration and adhesion to endothelial cells and relieve the local inflammation; furthermore, this effect was via estrogen receptor-ERK1/2-NF-kappaB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	estrogen receptor 1	Homo sapiens	199-216
21669275-11	2011	CONCLUSIONS: These findings suggest that calycosin can reduce AGEs-induced macrophage migration and adhesion to endothelial cells and relieve the local inflammation; furthermore, this effect was via estrogen receptor-ERK1/2-NF-kappaB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	mitogen-activated protein kinase 3	Homo sapiens	217-223
21669275-11	2011	CONCLUSIONS: These findings suggest that calycosin can reduce AGEs-induced macrophage migration and adhesion to endothelial cells and relieve the local inflammation; furthermore, this effect was via estrogen receptor-ERK1/2-NF-kappaB pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	nuclear factor kappa B subunit 1	Homo sapiens	224-233
33798579-4	2021	The experimental analysis indicated that calycosin exert its antioxidant effects against alpha-syn amyloid-triggered neurotoxicity by modifying the aggregation pathway toward formation of nontoxic spices via recovering the activity of SOD/CAT and GSH content and reducing the ROS content and caspase-3 activity.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	synuclein alpha	Homo sapiens	89-98
33798579-4	2021	The experimental analysis indicated that calycosin exert its antioxidant effects against alpha-syn amyloid-triggered neurotoxicity by modifying the aggregation pathway toward formation of nontoxic spices via recovering the activity of SOD/CAT and GSH content and reducing the ROS content and caspase-3 activity.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	catalase	Homo sapiens	239-242
33798579-4	2021	The experimental analysis indicated that calycosin exert its antioxidant effects against alpha-syn amyloid-triggered neurotoxicity by modifying the aggregation pathway toward formation of nontoxic spices via recovering the activity of SOD/CAT and GSH content and reducing the ROS content and caspase-3 activity.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	caspase 3	Homo sapiens	292-301
33798579-5	2021	This work may provide useful information about the mechanism of alpha-syn amyloid inhibition by calycosin and pave the way for developing some small molecules-based therapeutic platforms against Parkinson"s diseases.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	synuclein alpha	Homo sapiens	64-73
33031061-6	2020	Furthermore, the molecular pathways of calycosin-anti-meningitis were revealed, including suppression of NF-kappa B, Toll-like receptor, TNF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	nuclear factor kappa B subunit 1	Homo sapiens	105-115
33031061-6	2020	Furthermore, the molecular pathways of calycosin-anti-meningitis were revealed, including suppression of NF-kappa B, Toll-like receptor, TNF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	tumor necrosis factor	Homo sapiens	137-140
34834088-5	2021	Moreover, the inhibitory kinetics of calycosin on tyrosinase and their binding mechanisms are determined using molecular docking techniques, molecular dynamic simulations, and free energy analysis.	7,3'-dihydroxy-4'-methoxyisoflavone	37-46	tyrosinase	Danio rerio	50-60
34834088-8	2021	Furthermore, all the results of molecular docking, molecular dynamics simulations, and free energy analysis suggest that calycosin can directly bind to the active site of tyrosinase with very good binding affinity.	7,3'-dihydroxy-4'-methoxyisoflavone	121-130	tyrosinase	Danio rerio	171-181
34186122-7	2021	It was also shown that after incubation of the IFN-gamma samples at 50  C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	47-56
34186122-7	2021	It was also shown that after incubation of the IFN-gamma samples at 50  C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	127-136
34186122-7	2021	It was also shown that after incubation of the IFN-gamma samples at 50  C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	caspase 9	Homo sapiens	256-267
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cadherin 1	Homo sapiens	121-131
34217047-0	2021	Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3beta/beta-catenin signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	thymoma viral proto-oncogene 1	Mus musculus	112-115
34217047-0	2021	Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3beta/beta-catenin signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	glycogen synthase kinase 3 alpha	Mus musculus	116-124
34217047-0	2021	Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3beta/beta-catenin signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	catenin (cadherin associated protein), beta 1	Mus musculus	125-137
34176787-4	2021	Molecular docking analysis indicated the binding efficacy of calycosin with three of the targets, namely TP53, AKT1, and VEGFA.	7,3'-dihydroxy-4'-methoxyisoflavone	61-70	tumor protein p53	Homo sapiens	105-109
34176787-4	2021	Molecular docking analysis indicated the binding efficacy of calycosin with three of the targets, namely TP53, AKT1, and VEGFA.	7,3'-dihydroxy-4'-methoxyisoflavone	61-70	AKT serine/threonine kinase 1	Homo sapiens	111-115
34176787-4	2021	Molecular docking analysis indicated the binding efficacy of calycosin with three of the targets, namely TP53, AKT1, and VEGFA.	7,3'-dihydroxy-4'-methoxyisoflavone	61-70	vascular endothelial growth factor A	Homo sapiens	121-126
34176787-6	2021	In addition, the anti-CIRI actions of calycosin were primarily through suppression of the toll-like receptor, PI3K-AKT, TNF, MAPK, and VEGF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	AKT serine/threonine kinase 1	Homo sapiens	115-118
34176787-6	2021	In addition, the anti-CIRI actions of calycosin were primarily through suppression of the toll-like receptor, PI3K-AKT, TNF, MAPK, and VEGF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	tumor necrosis factor	Homo sapiens	120-123
34176787-6	2021	In addition, the anti-CIRI actions of calycosin were primarily through suppression of the toll-like receptor, PI3K-AKT, TNF, MAPK, and VEGF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	vascular endothelial growth factor A	Homo sapiens	135-139
34096887-0	2021	Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-beta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basic leucine zipper ATF-like transcription factor	Homo sapiens	84-88
34096887-0	2021	Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-beta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	transforming growth factor beta 1	Homo sapiens	89-98
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cadherin 2	Homo sapiens	154-164
34096887-2	2021	Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor (BATF) expression.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basic leucine zipper ATF-like transcription factor	Homo sapiens	194-198
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	vimentin	Homo sapiens	166-174
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basigin (Ok blood group)	Homo sapiens	176-181
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 2	Homo sapiens	183-188
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	matrix metallopeptidase 9	Homo sapiens	194-199
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basic leucine zipper ATF-like transcription factor	Homo sapiens	233-237
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	transforming growth factor beta 1	Homo sapiens	242-250
34096887-6	2021	TGFbeta1 knockdown reduced the migration and invasiveness of BATF-overexpressing breast cancer cells, whereas incubation with TGFbeta1 enhanced the migration and invasiveness of calycosin-treated breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	178-187	transforming growth factor beta 1	Homo sapiens	126-134
34096887-7	2021	Our findings demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFbeta1 signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	basic leucine zipper ATF-like transcription factor	Homo sapiens	109-113
34096887-7	2021	Our findings demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFbeta1 signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	transforming growth factor beta 1	Homo sapiens	114-122
35584953-13	2022	Overall, calycosin alleviated oxidative injury in spinal astrocytes by mediating the GP130/JAK/STAT pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	interleukin 6 cytokine family signal transducer	Rattus norvegicus	85-90
35264961-0	2022	Calycosin as a Novel PI3K Activator Reduces Inflammation and Fibrosis in Heart Failure Through AKT-IKK/STAT3 Axis.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
35288485-0	2022	Correction for: Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	pre-mRNA processing factor 31	Homo sapiens	136-140
35288485-0	2022	Correction for: Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	BRCA1 interacting helicase 1	Homo sapiens	150-155
35288485-0	2022	Correction for: Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERalpha.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	estrogen receptor 1	Homo sapiens	160-167
35584953-0	2022	Calycosin Alleviates Oxidative Injury in Spinal Astrocytes by Regulating the GP130/JAK/STAT Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 6 cytokine family signal transducer	Rattus norvegicus	77-82
35264961-0	2022	Calycosin as a Novel PI3K Activator Reduces Inflammation and Fibrosis in Heart Failure Through AKT-IKK/STAT3 Axis.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	103-108
35264961-7	2022	For further mechanistic study, proinflammatory-conditioned media (conditioned media)-induced H9C2 cell injury model and TGFbeta-stimulated cardiac fibroblast model were applied to determine the regulatory mechanisms of Cal.	7,3'-dihydroxy-4'-methoxyisoflavone	219-222	transforming growth factor alpha	Rattus norvegicus	120-127
35264961-13	2022	In the in vitro experiments, the phosphatidylinositol three kinase (PI3K) inhibitor LY294002 could abrogate the anti-inflammation and antifibrosis therapeutic effects of Cal, demonstrating that the cardioprotective effects of Cal were mediated through upregulations of PI3K and serine/threonine kinase (AKT).	7,3'-dihydroxy-4'-methoxyisoflavone	170-173	AKT serine/threonine kinase 1	Rattus norvegicus	303-306
35264961-14	2022	Conclusion: Cal inhibited inflammation and fibrosis via activation of the PI3K-AKT pathway in H9C2 cells, fibroblasts, and heart failure in postacute myocardial infarction rats.	7,3'-dihydroxy-4'-methoxyisoflavone	12-15	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
35163281-0	2022	Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cAMP responsive element binding protein 1	Mus musculus	101-105
35163281-0	2022	Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 14	Mus musculus	110-118
35163281-3	2022	Calycosin was effective in protecting B16F10 cells from alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis and tyrosinase activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	pro-opiomelanocortin-alpha	Mus musculus	56-92
35163281-3	2022	Calycosin was effective in protecting B16F10 cells from alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis and tyrosinase activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	STAM binding protein	Mus musculus	94-103
35163281-3	2022	Calycosin was effective in protecting B16F10 cells from alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis and tyrosinase activity.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	tyrosinase	Mus musculus	131-141
35163281-4	2022	This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells.	7,3'-dihydroxy-4'-methoxyisoflavone	255-264	melanogenesis associated transcription factor	Mus musculus	79-125
35163281-4	2022	This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells.	7,3'-dihydroxy-4'-methoxyisoflavone	255-264	melanogenesis associated transcription factor	Mus musculus	127-131
35204105-7	2022	Calycosin-fed PQ-exposed flies exhibit significant resistance against PQ-induced mortality and locomotor deficits in terms of reduced oxidative stress, loss of DA neurons, the depletion of dopamine content, and phosphorylated JNK-caspase-3 levels.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basket	Drosophila melanogaster	226-229
35163281-4	2022	This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells.	7,3'-dihydroxy-4'-methoxyisoflavone	255-264	tyrosinase	Mus musculus	200-210
35163281-4	2022	This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells.	7,3'-dihydroxy-4'-methoxyisoflavone	255-264	dopachrome tautomerase	Mus musculus	215-243
35204105-7	2022	Calycosin-fed PQ-exposed flies exhibit significant resistance against PQ-induced mortality and locomotor deficits in terms of reduced oxidative stress, loss of DA neurons, the depletion of dopamine content, and phosphorylated JNK-caspase-3 levels.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	Death executioner caspase related to Apopain/Yama	Drosophila melanogaster	230-239
35204105-8	2022	Additionally, mechanistic studies show that calycosin administration improves PQ-induced mitochondrial dysfunction and stimulates mitophagy and general autophagy with reduced pS6K and p4EBP1 levels, suggestive of a maintained energy balance between anabolic and catabolic processes, resulting in the inhibition of neuronal cell death.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	Ribosomal protein S6 kinase	Drosophila melanogaster	175-179
35163281-4	2022	This anti-melanogenic effect was accompanied by decreased expression levels of microphthalmia-associated transcription factor (MITF), a key protein controlling melanin synthesis, and its target genes tyrosinase and tyrosinase-related protein-2 (TRP-2) in calycosin-treated cells.	7,3'-dihydroxy-4'-methoxyisoflavone	255-264	dopachrome tautomerase	Mus musculus	245-250
35163281-5	2022	Mechanistically, we obtained the first evidence that calycosin-mediated MITF downregulation was attributable to its ability to block signaling pathways mediated by cAMP response element-binding protein (CREB) and p38 MAP kinase.	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	melanogenesis associated transcription factor	Mus musculus	72-76
35163281-5	2022	Mechanistically, we obtained the first evidence that calycosin-mediated MITF downregulation was attributable to its ability to block signaling pathways mediated by cAMP response element-binding protein (CREB) and p38 MAP kinase.	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	cAMP responsive element binding protein 1	Mus musculus	164-201
35163281-5	2022	Mechanistically, we obtained the first evidence that calycosin-mediated MITF downregulation was attributable to its ability to block signaling pathways mediated by cAMP response element-binding protein (CREB) and p38 MAP kinase.	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	cAMP responsive element binding protein 1	Mus musculus	203-207
35163281-6	2022	The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	mitogen-activated protein kinase 14	Mus musculus	46-49
35163281-6	2022	The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	tyrosinase	Mus musculus	137-147
35163281-6	2022	The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	cAMP responsive element binding protein 1	Mus musculus	179-183
35163281-6	2022	The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	mitogen-activated protein kinase 14	Mus musculus	188-196
35163281-7	2022	Moreover, the in vivo anti-melanogenic efficacy of calycosin was manifested by its ability to suppress body pigmentation and tyrosinase activity in zebrafish embryos.	7,3'-dihydroxy-4'-methoxyisoflavone	51-60	tyrosinase	Danio rerio	125-135
35035656-0	2022	Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	85-90
35035656-10	2022	In vivo, CAL afforded a protective effect against DOX-induced cardiac injury by improving myocardial function, inhibiting brain natriuretic peptide, and improving the changes of the histological morphology of DOX-treated mice.	7,3'-dihydroxy-4'-methoxyisoflavone	9-12	natriuretic peptide type B	Mus musculus	122-147
35035656-11	2022	Collectively, our findings confirmed that CAL alleviates DOX-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation in vivo and in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	42-45	NLR family, pyrin domain containing 3	Mus musculus	113-118