PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23851690-5	2013	Induction of 14-3-3gamma was rapid, peaking within 3 h of stimulation by LPSs, and sustained over the course of AID and CSR induction.	lpss	73-77	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	13-24
26324774-1	2015	LPSs are widely used to stimulate TLR4, but their effects on ion channels in immune cells are poorly known.	lpss	0-4	toll like receptor 4	Homo sapiens	34-38
23959899-5	2013	In the present work, we investigated the function of the crucial Toll-like receptor (TLR) adaptor protein myeloid differentiation factor 88 (MyD88) in systemic and local activation of adrenal gland inflammation and glucocorticoid production mediated by lipopolysachharides (LPSs).	lpss	274-278	myeloid differentiation primary response gene 88	Mus musculus	106-139
23959899-5	2013	In the present work, we investigated the function of the crucial Toll-like receptor (TLR) adaptor protein myeloid differentiation factor 88 (MyD88) in systemic and local activation of adrenal gland inflammation and glucocorticoid production mediated by lipopolysachharides (LPSs).	lpss	274-278	myeloid differentiation primary response gene 88	Mus musculus	141-146
22039958-6	2011	Comparative analysis of the immune responses induced by purified mutant and wild type LPSs showed that the mutant LPS induced significantly higher degrees of expression of TNF-alpha and IL-10 mRNA than did the wild type.	lpss	86-90	tumor necrosis factor	Mus musculus	172-181
22039958-6	2011	Comparative analysis of the immune responses induced by purified mutant and wild type LPSs showed that the mutant LPS induced significantly higher degrees of expression of TNF-alpha and IL-10 mRNA than did the wild type.	lpss	86-90	interleukin 10	Mus musculus	186-191
17967352-3	2007	The results clearly indicate that a polymer form of PGN in the LPSs elicited CecB.	lpss	63-67	cecropin B	Bombyx mori	77-81
20368351-6	2010	Reactivation of His(6)-Pla was higher with Y. pestis LPSs isolated from bacteria grown at 37 degrees C than with LPSs from cells grown at 25 degrees C. Lack of O antigens and the presence of the outer core region as well as a lowered level of acylation in LPS were found to enhance the Pla-LPS interaction.	lpss	53-57	plasminogen activator protease precursor	Yersinia pestis	23-26
16049662-6	2005	LPS may react directly with thiols, since after incubation of LPSs with glutathione alone (in reduced form) we observed a distinct decrease of the level of platelet GSH.	lpss	62-66	interferon regulatory factor 6	Homo sapiens	0-3
16672668-4	2006	Bacterial lipopolysachharides (LPSs) induced the production of NO and the expression of GFAP in mouse primary astrocytes.	lpss	31-35	glial fibrillary acidic protein	Mus musculus	88-92
16162968-4	2005	TRD significantly reduces the pathogenicity of prokaryotes, leading to a degeneration of the bacterial wall, and binds free lipoplysaccharides (LPSs) and exotoxins.	lpss	144-148	T cell receptor delta locus	Homo sapiens	0-3
11212586-1	2000	We compared the effects of LPSs from P. gingivalis and P. heparinolytica on the induction of tumor necrosis factor-alpha (TNF-alpha) production by murine peritoneal macrophages.	lpss	27-31	tumor necrosis factor	Mus musculus	122-131
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	0-22
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	24-27
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	44-47
14636417-4	2003	Pretreatment with LPSs inhibited the protein level of TNF-alpha in bronchoalveolar lavage fluid (BALF) and mRNA expression of CINC in lung tissue in response to subsequent LPS stimulation.	lpss	18-22	tumor necrosis factor	Rattus norvegicus	54-63
1283089-3	1992	The R-form part of the LPSs was separated by SDS-polyacrylamide gel electrophoresis and its antigen specificity analyzed by subsequent immunoblotting using Salmonella R-antisera (anti-Ra, -Rb1, -Rb2, -Rc).	lpss	23-27	RB transcriptional corepressor 1	Homo sapiens	189-192
8874768-4	1996	E. coli O55:B5, S. typhimurium, P. mirabilis O3, and C. burnetii LPSs, at dose 10 micrograms/mouse, decrease cytochrome P-450 level from 56 to 69%.	lpss	65-69	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	109-125
8874768-6	1996	The comparison of inhibitory activity of P. mirabilis complete, S and R types of LPSs indicate that lipid A portion of LPSs are sufficient to decrease the cytochrome P-450 level.	lpss	81-85	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	155-171
8874768-6	1996	The comparison of inhibitory activity of P. mirabilis complete, S and R types of LPSs indicate that lipid A portion of LPSs are sufficient to decrease the cytochrome P-450 level.	lpss	119-123	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	155-171
7669775-6	1995	Production of methemoglobin was prominent with chemically modified, partially deacetylated rough LPS, and was observed to a lesser extent both with native, complete rough and with native smooth LPSs.	lpss	194-198	hemoglobin subunit gamma 2	Homo sapiens	14-27
7642293-5	1995	The synthesis of IL-6 and IL-8 was also stimulated by 10 and 100 micrograms of both LPSs per ml, but IL-8 synthesis was not stimulated with E-LPS at 1 microgram/ml.	lpss	84-88	interleukin 6	Homo sapiens	17-21
7642293-5	1995	The synthesis of IL-6 and IL-8 was also stimulated by 10 and 100 micrograms of both LPSs per ml, but IL-8 synthesis was not stimulated with E-LPS at 1 microgram/ml.	lpss	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7532627-10	1995	In all cell populations, there was a peak of TNF production after approximately 4 h of stimulation with all LPSs tested.	lpss	108-112	tumor necrosis factor	Homo sapiens	45-48
1283089-8	1992	In contrast, almost all R-form LPSs showed a significant reaction with Rb1 antiserum.	lpss	31-35	RB transcriptional corepressor 1	Homo sapiens	71-74
2134298-4	1990	LPSs from A. actinomycetemcomitans ATCC 29522 and 29523 exhibited the same inducing activity for IL-1 production as did A-LPS.	lpss	0-4	interleukin 1 complex	Mus musculus	97-101
2731990-4	1989	By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes.	lpss	68-72	tumor necrosis factor	Homo sapiens	18-27
2731990-4	1989	By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes.	lpss	68-72	interleukin 6	Homo sapiens	33-37
30551352-7	2019	Increased secretion of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6, caused by LPSs was reversed by TFE; on the contrary, the anti-inflammatory cytokine IL-10 was upregulated.	lpss	90-94	tumor necrosis factor	Mus musculus	50-59
30551352-7	2019	Increased secretion of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6, caused by LPSs was reversed by TFE; on the contrary, the anti-inflammatory cytokine IL-10 was upregulated.	lpss	90-94	interleukin 1 beta	Mus musculus	61-69
30551352-7	2019	Increased secretion of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6, caused by LPSs was reversed by TFE; on the contrary, the anti-inflammatory cytokine IL-10 was upregulated.	lpss	90-94	interleukin 6	Mus musculus	74-78
30551352-8	2019	The proteins expressions of pro-inflammatory mediators iNOS and COX-2 induced by LPSs, were down-regulated by TFE.	lpss	81-85	cytochrome c oxidase II, mitochondrial	Mus musculus	64-69
28184004-3	2017	Additionally, persistent microbial insult (e.g. LPSs) induces cyclin-dependent kinase inhibitor 2A (CDKN2A/p16INK4a) expression and senescence in cultured cholangiocytes in an NRAS-dependent manner.	lpss	48-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	62-98
28184004-3	2017	Additionally, persistent microbial insult (e.g. LPSs) induces cyclin-dependent kinase inhibitor 2A (CDKN2A/p16INK4a) expression and senescence in cultured cholangiocytes in an NRAS-dependent manner.	lpss	48-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	100-106
28184004-3	2017	Additionally, persistent microbial insult (e.g. LPSs) induces cyclin-dependent kinase inhibitor 2A (CDKN2A/p16INK4a) expression and senescence in cultured cholangiocytes in an NRAS-dependent manner.	lpss	48-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	107-115
28184004-3	2017	Additionally, persistent microbial insult (e.g. LPSs) induces cyclin-dependent kinase inhibitor 2A (CDKN2A/p16INK4a) expression and senescence in cultured cholangiocytes in an NRAS-dependent manner.	lpss	48-52	NRAS proto-oncogene, GTPase	Homo sapiens	176-180
27669113-2	2016	Although TLR4 agonists (lipopolysaccharides; LPSs) derived from different bacterial species have different endotoxic activity, the impact of LPS chemotype on the downstream signalling is not fully understood.	lpss	45-49	toll like receptor 4	Homo sapiens	9-13