PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28137282-6	2017	In addition, we found that direct down-regulation of ERG20 expression, the branch point regulating geranyl diphosphate flux, does not improve geraniol production.	geranyl diphosphate	99-118	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	53-58
30095192-4	2018	It has been revealed that the best composite (40 % GPP@CdS composite) exhibits hydrogen production activity of 1321 mumol, which exceeds that of CdS by a factor of more than two, and can be used in at least seven cycles with negligible loss of activity.	geranyl diphosphate	51-54	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
30095192-4	2018	It has been revealed that the best composite (40 % GPP@CdS composite) exhibits hydrogen production activity of 1321 mumol, which exceeds that of CdS by a factor of more than two, and can be used in at least seven cycles with negligible loss of activity.	geranyl diphosphate	51-54	CDP-diacylglycerol synthase 1	Homo sapiens	145-148
29251770-0	2018	Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.	geranyl diphosphate	44-47	radical S-adenosyl methionine domain containing 2	Homo sapiens	6-13
29866124-5	2018	By expressing an Erg20 mutant to divert carbon flux from FPP to GPP, the geranyl acetate production increased to 2.64 mg/L.	geranyl diphosphate	64-67	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	17-22
28137282-7	2017	Therefore, we explored dynamic control of ERG20 expression to redistribute the precursor geranyl diphosphate flux and achieved a 3.4-fold increase in geraniol production after optimizing carbon source feeding.	geranyl diphosphate	89-108	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	42-47
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	geranyl diphosphate	137-156	terpene synthase 4	Zea mays	31-39
26781029-1	2016	INTRODUCTION: Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate to give rise to one molecule of geranyl diphosphate, which on a further reaction with another molecule of isopentenyl diphosphate forms the 15-carbon isoprenoid farnesyl diphosphate.	geranyl diphosphate	170-189	farnesyl diphosphate synthase	Homo sapiens	14-45
26781029-1	2016	INTRODUCTION: Farnesyl pyrophosphate synthase (FPPS) catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate to give rise to one molecule of geranyl diphosphate, which on a further reaction with another molecule of isopentenyl diphosphate forms the 15-carbon isoprenoid farnesyl diphosphate.	geranyl diphosphate	170-189	farnesyl diphosphate synthase	Homo sapiens	47-51
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	geranyl diphosphate	137-156	Inactive sesquithujene synthase	Zea mays	44-48
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	geranyl diphosphate	158-161	terpene synthase 4	Zea mays	31-39
25940560-1	2015	Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from maize (Zea mays) catalyze the conversion of farnesyl diphosphate (FDP) and geranyl diphosphate (GDP) into a complex mixture of sesquiterpenes and monoterpenes, respectively.	geranyl diphosphate	158-161	Inactive sesquithujene synthase	Zea mays	44-48
20516016-9	2010	Anti-CCP2 but not anti-CCP3 significantly distinguished the HBD from the GPP (95% CI).	geranyl diphosphate	73-76	AGBL carboxypeptidase 2	Homo sapiens	5-9
24777789-1	2014	Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15).	geranyl diphosphate	171-190	farnesyl diphosphate synthase	Homo sapiens	0-29
24777789-1	2014	Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15).	geranyl diphosphate	192-195	farnesyl diphosphate synthase	Homo sapiens	0-29
24752813-4	2014	Considering the compartments of these TPS proteins and available substrates, the linalool peak induced by geraniol might be attributed to TPS5 and TPS37, both of them putatively localized in the plastids where high levels of monoterpene substrate geranyl diphosphate exist.	geranyl diphosphate	247-266	(3S,6E)-nerolidol synthase 1-like	Solanum lycopersicum	147-152
24831707-1	2014	Recently it was shown that monoterpenes in tomato trichomes (Solanum lycopersicum) are synthesized by phellandrene synthase 1 (PHS1) from the non-canonical substrate neryl diphosphate (NPP), the cis-isomer of geranyl diphosphate (GPP).	geranyl diphosphate	209-228	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic	Solanum lycopersicum	127-131
24831707-1	2014	Recently it was shown that monoterpenes in tomato trichomes (Solanum lycopersicum) are synthesized by phellandrene synthase 1 (PHS1) from the non-canonical substrate neryl diphosphate (NPP), the cis-isomer of geranyl diphosphate (GPP).	geranyl diphosphate	230-233	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic	Solanum lycopersicum	127-131
24831707-2	2014	As PHS1 accepts both NPP and GPP substrates forming different monoterpenes, it was overexpressed in tomato fruits to test if NPP is also available in a tissue highly active in carotenoid production.	geranyl diphosphate	29-32	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic	Solanum lycopersicum	3-7
21757687-7	2011	In RNA interference experiments, P3H2 protein synthesis was suppressed coordinately with prolyl 3-hydroxylation at Pro-944, Pro-707, and the C-terminal GPP repeat of the pNalpha1(II) chain, but Pro-986 remained fully hydroxylated.	geranyl diphosphate	152-155	prolyl 3-hydroxylase 2	Homo sapiens	33-37
19856009-8	2009	Treatment of cells with inhibitors of the isoprenoid biosynthetic pathway results in marked changes in GPP levels: the HMG-CoA reductase inhibitor lovastatin decreases GPP levels by over 50%, while the FPP synthase inhibitor zoledronic acid increases GPP levels 16- to 107-fold.	geranyl diphosphate	103-106	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	119-136
19633972-3	2009	The reactions leading to the production of geranyl diphosphate (C10), farnesyl diphosphate (C15) and geranylgeranyl diphosphate (C20), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases.	geranyl diphosphate	43-62	homeobox C10	Homo sapiens	64-67
19633972-3	2009	The reactions leading to the production of geranyl diphosphate (C10), farnesyl diphosphate (C15) and geranylgeranyl diphosphate (C20), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases.	geranyl diphosphate	43-62	placenta associated 8	Homo sapiens	92-95
19856009-8	2009	Treatment of cells with inhibitors of the isoprenoid biosynthetic pathway results in marked changes in GPP levels: the HMG-CoA reductase inhibitor lovastatin decreases GPP levels by over 50%, while the FPP synthase inhibitor zoledronic acid increases GPP levels 16- to 107-fold.	geranyl diphosphate	103-106	farnesyl diphosphate synthase	Homo sapiens	202-214
19856009-8	2009	Treatment of cells with inhibitors of the isoprenoid biosynthetic pathway results in marked changes in GPP levels: the HMG-CoA reductase inhibitor lovastatin decreases GPP levels by over 50%, while the FPP synthase inhibitor zoledronic acid increases GPP levels 16- to 107-fold.	geranyl diphosphate	168-171	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	119-136
15548532-6	2005	Yeast Deltacoq1 mutants harboring diverse Coq1 orthologs from prokaryotic species produce distinct sizes of polyprenyl diphosphate and hence distinct isoforms of Q including Q(7), Q(8), Q(9), or Q(10) (Okada, K., Kainou, T., Matsuda, H., and Kawamukai, M. (1998) FEBS Lett.	geranyl diphosphate	108-130	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	42-46
15765206-6	2005	Cloning of the gene reveals that it is the only gene in C. elegans for isopentenyl-diphosphate isomerase, an enzyme that is important for the synthesis of lipophilic molecules, including farnesyl and geranyl diphosphates.	geranyl diphosphate	200-220	Isopentenyl-diphosphate Delta-isomerase	Caenorhabditis elegans	71-104
15548532-9	2005	These data suggest that the lipid product of Coq1p or a Q-intermediate derived from polyprenyl diphosphate is involved in stabilizing the Coq3, Coq4, and Coq6 polypeptides.	geranyl diphosphate	84-106	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	45-50
15548532-9	2005	These data suggest that the lipid product of Coq1p or a Q-intermediate derived from polyprenyl diphosphate is involved in stabilizing the Coq3, Coq4, and Coq6 polypeptides.	geranyl diphosphate	84-106	hexaprenyldihydroxybenzoate methyltransferase	Saccharomyces cerevisiae S288C	138-142
15548532-9	2005	These data suggest that the lipid product of Coq1p or a Q-intermediate derived from polyprenyl diphosphate is involved in stabilizing the Coq3, Coq4, and Coq6 polypeptides.	geranyl diphosphate	84-106	ubiquinone biosynthesis protein COQ4	Saccharomyces cerevisiae S288C	144-148
15548532-9	2005	These data suggest that the lipid product of Coq1p or a Q-intermediate derived from polyprenyl diphosphate is involved in stabilizing the Coq3, Coq4, and Coq6 polypeptides.	geranyl diphosphate	84-106	putative N,N-dimethylaniline monooxygenase COQ6	Saccharomyces cerevisiae S288C	154-158
15604701-4	2004	The mitochondrial fraction that was prepared from the yeast mutant, which expressed the AtPPT1 gene, exhibited 4HPT enzymatic activity with geranyl diphosphate (GPP) as the prenyl substrate.	geranyl diphosphate	140-159	polyprenyltransferase 1	Arabidopsis thaliana	88-94
15299125-7	2004	The purified recombinant AtTPS-Cin displayed similar biochemical properties to other known monoterpene synthases, except for a relatively low K(m) value for geranyl diphosphate of 0.2 microm.	geranyl diphosphate	157-176	terpene synthase-like sequence-1,8-cineole	Arabidopsis thaliana	25-34
15604701-4	2004	The mitochondrial fraction that was prepared from the yeast mutant, which expressed the AtPPT1 gene, exhibited 4HPT enzymatic activity with geranyl diphosphate (GPP) as the prenyl substrate.	geranyl diphosphate	161-164	polyprenyltransferase 1	Arabidopsis thaliana	88-94
11111075-3	2000	Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate.	geranyl diphosphate	181-199	mevalonate kinase	Homo sapiens	22-39
11744717-3	2002	They were functionally expressed in yeast COQ2 disruptant and showed a strict substrate specificity for geranyl diphosphate as the prenyl donor, in contrast to ubiquinone biosynthetic enzymes, suggesting that they are involved in the biosynthesis of shikonin, a naphthoquinone secondary metabolite.	geranyl diphosphate	104-123	4-hydroxybenzoate octaprenyltransferase	Saccharomyces cerevisiae S288C	42-46
7856400-9	1994	FPP synthase catalyzing the formation of FPP from DMAPP and IPP was also purified to homogeneity from the same organ by a similar affinity chromatography procedure using a GPP analog, O-(6-amino-1-hexyl)-P-geranylmethyl phosphonophosphate as a ligand.	geranyl diphosphate	172-175	farnesyl pyrophosphate synthase	Bos taurus	0-12
10700382-6	2000	Functional expression of AtTPS10 in Escherichia coli yielded an active monoterpene synthase enzyme, which converted geranyl diphosphate (C(10)) into the acyclic monoterpenes beta-myrcene and (E)-beta-ocimene and small amounts of cyclic monoterpenes.	geranyl diphosphate	116-135	terpene synthase 10	Arabidopsis thaliana	25-32
8631820-15	1996	We demonstrate that FPS2 catalyzes the two successive condensations of IPP with both DMAPP and geranyl diphosphate leading to FPP.	geranyl diphosphate	95-114	farnesyl diphosphate synthase 2	Arabidopsis thaliana	20-24
8051156-10	1994	Farnesyl-diphosphate synthase catalyzing the formation of farnesyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate was also purified to homogeneity from the same organ by similar affinity chromatography using a geranyl diphosphate analog, O-(6-amino-1-hexyl)-P-geranylmethyl phosphonophosphate, as a ligand.	geranyl diphosphate	234-253	farnesyl pyrophosphate synthase	Bos taurus	0-29
1725762-5	1991	VIP (10 nM) induced a potent and reversible inhibition of the contractions of GPP induced by LTD4 (1-30 pmol) but did not affect those due to ACh (1-100 nmol) or histamine (1-30 nmol).	geranyl diphosphate	78-81	VIP peptides	Cavia porcellus	0-3
35285188-4	2022	In S. cerevisiae, the production of geranyl pyrophosphate(GPP) and farnesyl pyrophosphate(FPP) is catalyzed by a bifunctional enzyme farnesyl pyrophosphate synthetase(encoded by ERG20 gene) which is inclined to synthesize FPP essential for yeast growth.	geranyl diphosphate	58-61	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	178-183
2018485-7	1991	The purified fusion protein has FPP synthase condensation activities in the presence of both substrates, isopentenyl diphosphate and geranyl diphosphate.	geranyl diphosphate	133-152	farnesyl diphosphate synthase	Homo sapiens	32-44
35285188-7	2022	Further, we reconstructed the metabolic pathway by using GPP and neryl diphosphate(NPP), cis-GPP as substrates in HP001-pERG1-ERG20.	geranyl diphosphate	57-60	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	126-131
2861030-10	1985	(ii) The calmodulin antagonist, trifluoperazine (10(-5)M), completely abolishes the response to 5-HT, even in fibres preinjected with Gpp(NH)p. (iii) Diphenylhydantoin is less effective than trifluoperazine (TFP).	geranyl diphosphate	134-137	calmodulin 1	Homo sapiens	9-19
6150553-3	1984	Thyroid-stimulating hormone (0.3 IU/ml), guanosine triphosphate (10(-4) M), and Gpp (NH)p(10(-4) M) stimulated AC in all thyroid tissues, although in two tissues (normal) Gpp (NH)p failed to cause a significant increase.	geranyl diphosphate	80-83	adenylate cyclase 1	Homo sapiens	111-113
6300646-4	1983	To define further the mechanisms by which Ca2+ and ACTH interact with guanine nucleotides, we have correlated the binding of [3H]Gpp(NH)p to adrenal membranes and solubilized membrane proteins with activation of membrane-bound and solubilized adenylate cyclase.	geranyl diphosphate	129-132	proopiomelanocortin	Homo sapiens	51-55
33857581-5	2021	Geranyl diphosphate (GPP), the most important precursor for monoterpenes, was enhanced by replacing the wild farnesyl diphosphate synthase (Erg20) with the mutant Erg20F96W, increasing the citronellol titer to 406.01 mg/L without negative influence on cell growth.	geranyl diphosphate	0-19	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	140-145
33857581-5	2021	Geranyl diphosphate (GPP), the most important precursor for monoterpenes, was enhanced by replacing the wild farnesyl diphosphate synthase (Erg20) with the mutant Erg20F96W, increasing the citronellol titer to 406.01 mg/L without negative influence on cell growth.	geranyl diphosphate	0-19	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	163-168
33857581-5	2021	Geranyl diphosphate (GPP), the most important precursor for monoterpenes, was enhanced by replacing the wild farnesyl diphosphate synthase (Erg20) with the mutant Erg20F96W, increasing the citronellol titer to 406.01 mg/L without negative influence on cell growth.	geranyl diphosphate	21-24	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	140-145
33857581-5	2021	Geranyl diphosphate (GPP), the most important precursor for monoterpenes, was enhanced by replacing the wild farnesyl diphosphate synthase (Erg20) with the mutant Erg20F96W, increasing the citronellol titer to 406.01 mg/L without negative influence on cell growth.	geranyl diphosphate	21-24	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	163-168