PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33786819-8	2021	Conversely, 1, 25-dihydroxyvitamin D3, as agonists of TRPV5, reversed the oxoglaucine induced calcium influx inhibition and autophagy activation, demonstrating the association of oxoglaucine with TRPV5.	oxoglaucine	179-190	transient receptor potential cation channel subfamily V member 5	Homo sapiens	196-201
33877422-5	2021	Applying the CAA approach with a combination of pleconaril (capsid binder), guanidine HCl (viral 2C inhibitor), and oxoglaucine (PI4KB inhibitor) (PGO) was found to be effective in the treatment of newborn mice infected with a massive inoculum (20 MLD50) of the coxsackievirus B3 cardiotropic Woodruff or neurotropic Nancy strain.	oxoglaucine	116-127	phosphatidylinositol 4-kinase beta	Mus musculus	129-134
33786819-0	2021	Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/Calmodulin/CAMK-II pathway.	oxoglaucine	0-11	transient receptor potential cation channel subfamily V member 5	Homo sapiens	97-102
33786819-0	2021	Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/Calmodulin/CAMK-II pathway.	oxoglaucine	0-11	calmodulin 1	Homo sapiens	103-113
33786819-10	2021	CONCLUSION AND IMPLICATIONS: Oxoglaucine protects against cartilage damage by blocking TRPV5/CAMK-II/Calmodulin pathway to inhibit Ca2+ influx and activate autophagy.	oxoglaucine	29-40	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	87-92
33786819-0	2021	Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/Calmodulin/CAMK-II pathway.	oxoglaucine	0-11	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	114-121
33786819-2	2021	In this study, we use a novel TRPV5 inhibitor - oxoglaucine to attenuate progression of deterioration and pathological changes on OA patient-derived chondrocytes and OA animal model by activating autophagy.	oxoglaucine	48-59	transient receptor potential cation channel subfamily V member 5	Homo sapiens	30-35
33786819-10	2021	CONCLUSION AND IMPLICATIONS: Oxoglaucine protects against cartilage damage by blocking TRPV5/CAMK-II/Calmodulin pathway to inhibit Ca2+ influx and activate autophagy.	oxoglaucine	29-40	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	93-100
33786819-10	2021	CONCLUSION AND IMPLICATIONS: Oxoglaucine protects against cartilage damage by blocking TRPV5/CAMK-II/Calmodulin pathway to inhibit Ca2+ influx and activate autophagy.	oxoglaucine	29-40	calmodulin 1	Homo sapiens	101-111
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	tumor necrosis factor	Homo sapiens	112-121
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	interleukin 6	Homo sapiens	123-127
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	interleukin 1 alpha	Homo sapiens	129-137
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	matrix metallopeptidase 13	Homo sapiens	139-145
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	caspase 3	Homo sapiens	147-153
33786819-5	2021	KEY RESULTS: Oxoglaucine suppressed the expression of pro-inflammatory and apoptosis-related cytokines, such as TNF-alpha, IL-6, IL-1beta, MMP-13, CASP-3, BAX, and prevented matrix degradation in OA chondrocytes.	oxoglaucine	13-24	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
33786819-8	2021	Conversely, 1, 25-dihydroxyvitamin D3, as agonists of TRPV5, reversed the oxoglaucine induced calcium influx inhibition and autophagy activation, demonstrating the association of oxoglaucine with TRPV5.	oxoglaucine	74-85	transient receptor potential cation channel subfamily V member 5	Homo sapiens	54-59
33786819-8	2021	Conversely, 1, 25-dihydroxyvitamin D3, as agonists of TRPV5, reversed the oxoglaucine induced calcium influx inhibition and autophagy activation, demonstrating the association of oxoglaucine with TRPV5.	oxoglaucine	74-85	transient receptor potential cation channel subfamily V member 5	Homo sapiens	196-201
33786819-8	2021	Conversely, 1, 25-dihydroxyvitamin D3, as agonists of TRPV5, reversed the oxoglaucine induced calcium influx inhibition and autophagy activation, demonstrating the association of oxoglaucine with TRPV5.	oxoglaucine	179-190	transient receptor potential cation channel subfamily V member 5	Homo sapiens	54-59
34734425-0	2022	Oxoglaucine alleviates osteoarthritis by activation of autophagy via blockade of Ca2+ influx and TRPV5/calmodulin/CAMK-II pathway.	oxoglaucine	0-11	transient receptor potential cation channel subfamily V member 5	Homo sapiens	97-102
34734425-0	2022	Oxoglaucine alleviates osteoarthritis by activation of autophagy via blockade of Ca2+ influx and TRPV5/calmodulin/CAMK-II pathway.	oxoglaucine	0-11	calmodulin 1	Homo sapiens	103-113
34734425-0	2022	Oxoglaucine alleviates osteoarthritis by activation of autophagy via blockade of Ca2+ influx and TRPV5/calmodulin/CAMK-II pathway.	oxoglaucine	0-11	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	114-121
25891300-2	2015	In the present study, PI4KB was identified as the direct target of the plant-derived anti-picornavirus compounds, oxoglaucine and pachypodol (also known as Ro 09-0179).	oxoglaucine	114-125	phosphatidylinositol 4-kinase beta	Homo sapiens	22-27
11025179-1	2000	The alkaloid oxoglaucine reduced CD4+ cell clones in adult mice and decreased CD4+, CD8+ and Ig+ levels in newborn mice.	oxoglaucine	13-24	CD4 antigen	Mus musculus	33-36
11025179-1	2000	The alkaloid oxoglaucine reduced CD4+ cell clones in adult mice and decreased CD4+, CD8+ and Ig+ levels in newborn mice.	oxoglaucine	13-24	CD4 antigen	Mus musculus	78-81