PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35035671-0	2022	Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS.	forsythiaside	0-15	NADPH oxidase 4	Homo sapiens	77-81
35055377-0	2022	Forsythoside A Alleviates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Regulating Th17 Cells and IL-17A Expression.	forsythiaside	0-14	interleukin 17A	Mus musculus	107-113
35055377-11	2022	The expression of IL-6, IL-17, and Ki-67 was downregulated in the forsythoside-A-treated groups.	forsythiaside	66-80	interleukin 6	Mus musculus	18-22
35055377-11	2022	The expression of IL-6, IL-17, and Ki-67 was downregulated in the forsythoside-A-treated groups.	forsythiaside	66-80	interleukin 17A	Mus musculus	24-29
35055377-11	2022	The expression of IL-6, IL-17, and Ki-67 was downregulated in the forsythoside-A-treated groups.	forsythiaside	66-80	antigen identified by monoclonal antibody Ki 67	Mus musculus	35-40
35055377-12	2022	Th17 cell expression in inguinal lymph nodes and IL-17A secretion was suppressed by forsythoside A.	forsythiaside	84-98	interleukin 17A	Mus musculus	49-55
35055377-13	2022	In conclusion, forsythoside A was found to alleviate imiquimod-induced psoriasis-like dermatitis in mice by suppressing Th17 development and IL-17A secretion.	forsythiaside	15-29	interleukin 17A	Mus musculus	141-147
31757053-4	2019	Forsythiaside A was used to treat C57BL/6J mice and MAVS-/- mice infected with mouse-adapted influenza A virus FM1 (H1N1, A/FM1/1/47 strain), and the physical parameters (body weight and lung index) and the expression of key factors in the RLRs/NF-kappaB signaling pathway were evaluated.	forsythiaside	0-15	mitochondrial antiviral signaling protein	Mus musculus	52-56
33953587-0	2021	Forsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition.	forsythiaside	0-14	matrix metallopeptidase 12	Mus musculus	129-134
33072499-6	2021	Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2.	forsythiaside	25-39	angiotensin converting enzyme 2	Homo sapiens	129-133
31842335-0	2019	Forsythoside A and Forsythoside B Contribute to Shuanghuanglian Injection-Induced Pseudoallergic Reactions through the RhoA/ROCK Signaling Pathway.	forsythiaside	0-14	ras homolog family member A	Mus musculus	119-123
31842335-4	2019	We demonstrated that forsythoside A and forsythoside B contributed to Shuanghuanglian injection-induced pseudoallergic reactions through activation of the RhoA/ROCK signaling pathway.	forsythiaside	21-35	ras homolog family member A	Mus musculus	155-159
31842335-7	2019	Correspondingly, treatment with forsythoside A and forsythoside B disrupted the endothelial barrier and augmented the expression of GTP-RhoA, p-MYPT1, and p-MLC2 in a concentration-dependent manner.	forsythiaside	32-46	ras homolog family member A	Mus musculus	136-140
31842335-7	2019	Correspondingly, treatment with forsythoside A and forsythoside B disrupted the endothelial barrier and augmented the expression of GTP-RhoA, p-MYPT1, and p-MLC2 in a concentration-dependent manner.	forsythiaside	32-46	protein phosphatase 1, regulatory subunit 12A	Mus musculus	144-149
31842335-7	2019	Correspondingly, treatment with forsythoside A and forsythoside B disrupted the endothelial barrier and augmented the expression of GTP-RhoA, p-MYPT1, and p-MLC2 in a concentration-dependent manner.	forsythiaside	32-46	myosin, light polypeptide 2, regulatory, cardiac, slow	Mus musculus	157-161
30048725-0	2018	Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE).	forsythiaside	29-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78
31173213-0	2019	Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways.	forsythiaside	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-0	2018	Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE).	forsythiaside	29-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	54-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	54-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
28687196-0	2017	Protective effects of Forsythoside A on amyloid beta-induced apoptosis in PC12 cells by downregulating acetylcholinesterase.	forsythiaside	22-36	acetylcholinesterase	Rattus norvegicus	103-123
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	54-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	forsythiaside	54-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-5	2018	Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
30048725-5	2018	Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence.	forsythiaside	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
30048725-7	2018	Spectroscopy data and docking analysis powerfully support the findings that forsythiaside inhibit AChE activity more strongly than rutin.	forsythiaside	76-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
28687196-4	2017	This study examined the inhibitory acetylcholinesterase activities of Forsythoside A at chemical and biological level.	forsythiaside	70-84	acetylcholinesterase	Rattus norvegicus	35-55
28687196-5	2017	Forsythoside A inhibited acetylcholinesterase in a mixed type of inhibition, with Ki of 47.68muM.	forsythiaside	0-14	acetylcholinesterase	Rattus norvegicus	25-45
28687196-7	2017	In PC12 cells Forsythoside A increased cell viability and suppressed acetylcholinesterase increased by Abeta25-35, thus alleviated the corresponding apoptosis.	forsythiaside	14-28	acetylcholinesterase	Rattus norvegicus	69-89
28687196-8	2017	Taken together, these results suggest that Forsythoside A has the protective effects on Abeta25-35-induced apoptosis in PC12 cells by downregulating acetylcholinesterase, making it a potential functional food ingredient or drug candidate for the treatment of AD.	forsythiaside	43-57	acetylcholinesterase	Rattus norvegicus	149-169
26209933-0	2015	Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-kappaB.	forsythiaside	0-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
28534936-0	2017	Forsythoside A exerts an anti-endotoxin effect by blocking the LPS/TLR4 signaling pathway and inhibiting Tregs in vitro.	forsythiaside	0-14	toll-like receptor 4	Mus musculus	67-71
28534936-2	2017	Forsythoside A (FTA), a monomer of phenethyl alcohol glycosides extracted from Forsythia suspensa, has been shown to possess anti-bacterial and immunomodulatory properties.	forsythiaside	0-14	farnesyltransferase, CAAX box, alpha	Mus musculus	16-19
27310729-0	2017	Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro.	forsythiaside	25-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	47-62
27310729-3	2017	However, the effects of phillyrin and forsythoside A on the activities of cytochrome P450 (CYP450) remain unclear.	forsythiaside	38-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	74-89
27310729-3	2017	However, the effects of phillyrin and forsythoside A on the activities of cytochrome P450 (CYP450) remain unclear.	forsythiaside	38-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	91-97
27310729-5	2017	This study aimed to investigate the effects of phillyrin and forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro.	forsythiaside	61-75	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	97-103
27310729-5	2017	This study aimed to investigate the effects of phillyrin and forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro.	forsythiaside	61-75	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	105-112
27310729-5	2017	This study aimed to investigate the effects of phillyrin and forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro.	forsythiaside	61-75	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	114-120
27310729-5	2017	This study aimed to investigate the effects of phillyrin and forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro.	forsythiaside	61-75	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	125-131
27310729-12	2017	Moreover, forsythoside A had inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.	forsythiaside	10-24	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	68-74
27310729-12	2017	Moreover, forsythoside A had inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.	forsythiaside	10-24	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	79-86
28123347-0	2017	Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function.	forsythiaside	0-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-126
28123347-2	2017	Forsythoside A (FT-A) is the most abundant phenylethanoid glycosides in Fructus Forsythiae, which has been prescribed as a medicinal herb for treating fever in China for a long history.	forsythiaside	0-14	farnesyltransferase, CAAX box, alpha	Mus musculus	16-20
27617959-6	2016	At same time, FTA can enhance the secretion of IL-2.	forsythiaside	14-17	interleukin 2	Homo sapiens	47-51
26498935-0	2016	Forsythiaside A Exhibits Anti-inflammatory Effects in LPS-Stimulated BV2 Microglia Cells Through Activation of Nrf2/HO-1 Signaling Pathway.	forsythiaside	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
26498935-0	2016	Forsythiaside A Exhibits Anti-inflammatory Effects in LPS-Stimulated BV2 Microglia Cells Through Activation of Nrf2/HO-1 Signaling Pathway.	forsythiaside	0-15	heme oxygenase 1	Mus musculus	116-120
26498935-6	2016	Our results showed that forsythiaside A significantly inhibited LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production.	forsythiaside	24-37	tumor necrosis factor	Mus musculus	99-108
26498935-6	2016	Our results showed that forsythiaside A significantly inhibited LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production.	forsythiaside	24-37	interleukin 1 beta	Mus musculus	110-118
26498935-9	2016	In conclusion, this study demonstrates that forsythiaside A inhibits LPS-induced inflammatory responses in BV2 microglia cells and primary microglia cells through inhibition of NF-kappaB activation and activation of Nrf2/HO-1 signaling pathway.	forsythiaside	44-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	216-220
26498935-9	2016	In conclusion, this study demonstrates that forsythiaside A inhibits LPS-induced inflammatory responses in BV2 microglia cells and primary microglia cells through inhibition of NF-kappaB activation and activation of Nrf2/HO-1 signaling pathway.	forsythiaside	44-59	heme oxygenase 1	Mus musculus	221-225
26209933-0	2015	Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-kappaB.	forsythiaside	0-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
26209933-9	2015	Western blot analysis showed that forsythiaside inhibited cigarette smoke-induced NF-kappaB activation.	forsythiaside	34-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
26209933-10	2015	In addition, forsythiaside dose-dependently up-regulated the expression of Nrf2 and HO-1.	forsythiaside	13-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
26209933-10	2015	In addition, forsythiaside dose-dependently up-regulated the expression of Nrf2 and HO-1.	forsythiaside	13-26	heme oxygenase 1	Mus musculus	84-88
25797347-2	2015	In the present study, the hepatoprotective effect of forsythiaside A was investigated in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced acute liver injury in mice.	forsythiaside	53-68	toll-like receptor 4	Mus musculus	109-112
25797347-4	2015	Forsythiaside A was administrated 1h prior to LPS/GalN exposure.	forsythiaside	0-15	toll-like receptor 4	Mus musculus	46-49
25797347-6	2015	Moreover, forsythiaside A inhibited NF-kappaB activation, serum TNF-alpha and hepatic TNF-alpha levels induced by LPS/GalN.	forsythiaside	10-25	tumor necrosis factor	Mus musculus	64-73
25797347-6	2015	Moreover, forsythiaside A inhibited NF-kappaB activation, serum TNF-alpha and hepatic TNF-alpha levels induced by LPS/GalN.	forsythiaside	10-25	tumor necrosis factor	Mus musculus	86-95
25797347-6	2015	Moreover, forsythiaside A inhibited NF-kappaB activation, serum TNF-alpha and hepatic TNF-alpha levels induced by LPS/GalN.	forsythiaside	10-25	toll-like receptor 4	Mus musculus	114-117
25797347-7	2015	Furthermore, we found that forsythiaside A up-regulated the expression of Nrf2 and heme oxygenase-1.	forsythiaside	27-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
25797347-7	2015	Furthermore, we found that forsythiaside A up-regulated the expression of Nrf2 and heme oxygenase-1.	forsythiaside	27-42	heme oxygenase 1	Mus musculus	83-99
21361037-1	2010	This study is to investigate the effects of concentration, intestinal section, pH, paracellular route, substrate/inhibitor of enzyme (CYP3A) and proteins (P-gp, MRP2, SGL1) on the absorption of forsythoside A.	forsythiaside	194-208	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	134-139
25344274-8	2015	Further, increased nuclear levels of Nrf2 and up-regulation of antioxidant enzymes (Mn/SOD and CAT) were detected in forsythiaside-treated cells, indicating the anti-oxidative effects of forsythiaside might be associated with activation of Nrf2 pathway.	forsythiaside	117-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
25344274-8	2015	Further, increased nuclear levels of Nrf2 and up-regulation of antioxidant enzymes (Mn/SOD and CAT) were detected in forsythiaside-treated cells, indicating the anti-oxidative effects of forsythiaside might be associated with activation of Nrf2 pathway.	forsythiaside	117-130	catalase	Rattus norvegicus	95-98
25344274-8	2015	Further, increased nuclear levels of Nrf2 and up-regulation of antioxidant enzymes (Mn/SOD and CAT) were detected in forsythiaside-treated cells, indicating the anti-oxidative effects of forsythiaside might be associated with activation of Nrf2 pathway.	forsythiaside	117-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	240-244
25344274-8	2015	Further, increased nuclear levels of Nrf2 and up-regulation of antioxidant enzymes (Mn/SOD and CAT) were detected in forsythiaside-treated cells, indicating the anti-oxidative effects of forsythiaside might be associated with activation of Nrf2 pathway.	forsythiaside	187-200	NFE2 like bZIP transcription factor 2	Rattus norvegicus	240-244
22430364-7	2012	The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively.	forsythiaside	63-76	ATP binding cassette subfamily C member 2	Canis lupus familiaris	11-15
22430364-7	2012	The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively.	forsythiaside	63-76	BAF nuclear assembly factor 1	Mus musculus	27-32
22430364-7	2012	The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively.	forsythiaside	63-76	ATP binding cassette subfamily C member 2	Canis lupus familiaris	165-169
22430364-7	2012	The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively.	forsythiaside	63-76	BAF nuclear assembly factor 1	Mus musculus	174-179
22430364-8	2012	The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors.	forsythiaside	154-167	ATP binding cassette subfamily C member 2	Canis lupus familiaris	21-25
22430364-8	2012	The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors.	forsythiaside	154-167	BAF nuclear assembly factor 1	Mus musculus	30-35
22430364-8	2012	The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors.	forsythiaside	154-167	ATP binding cassette subfamily C member 2	Canis lupus familiaris	178-182
22430364-8	2012	The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors.	forsythiaside	154-167	BAF nuclear assembly factor 1	Mus musculus	187-192
22430364-11	2012	This study presents direct evidence that forsythiaside is effluxed by both MRP2 and Bcrp1, which may contribute to its poor oral bioavailability.	forsythiaside	41-54	ATP binding cassette subfamily C member 2	Canis lupus familiaris	75-79
22430364-11	2012	This study presents direct evidence that forsythiaside is effluxed by both MRP2 and Bcrp1, which may contribute to its poor oral bioavailability.	forsythiaside	41-54	BAF nuclear assembly factor 1	Mus musculus	84-89
21501605-5	2011	The forsythiaside administration significantly increased the number of viable neurons detected by neuronal nuclei immunostaining and decreased degenerating neuronal cells detected by Fluoro-Jade B staining in the hippocampal CA1 region, at the 7th day post-ischemia (P<0.05).	forsythiaside	4-17	carbonic anhydrase 1	Homo sapiens	225-228
21501605-6	2011	Forsythiaside also significantly decreased the number of ionized calcium-binding adaptor molecule-1-detected activated microglia and glial fibrillary acidic protein-detected astrocytes, both of which were increased after ischemic insults, and decreased interleukin-1beta and tumor necrosis factor-alpha expression levels, which were also increased after the insults (P<0.05).	forsythiaside	0-13	interleukin 1 beta	Homo sapiens	253-302
21501605-8	2011	These results suggest that forsythiaside exhibits neuroprotective properties, which are, in part, mediated by its anti-inflammatory activities supported by forsythiaside-induced reductions of activated glial cells and expression levels of interleukin-1beta and tumor necrosis factor-alpha.	forsythiaside	27-40	interleukin 1 beta	Homo sapiens	239-288
21501605-8	2011	These results suggest that forsythiaside exhibits neuroprotective properties, which are, in part, mediated by its anti-inflammatory activities supported by forsythiaside-induced reductions of activated glial cells and expression levels of interleukin-1beta and tumor necrosis factor-alpha.	forsythiaside	156-169	interleukin 1 beta	Homo sapiens	239-288
21361037-1	2010	This study is to investigate the effects of concentration, intestinal section, pH, paracellular route, substrate/inhibitor of enzyme (CYP3A) and proteins (P-gp, MRP2, SGL1) on the absorption of forsythoside A.	forsythiaside	194-208	ATP binding cassette subfamily C member 2	Rattus norvegicus	161-165
21361037-10	2010	In addition, the substrates of P-gp or CYP3A had dose-dependent effect on the absorption of forsythoside A.	forsythiaside	92-106	phosphoglycolate phosphatase	Rattus norvegicus	31-35
21361037-10	2010	In addition, the substrates of P-gp or CYP3A had dose-dependent effect on the absorption of forsythoside A.	forsythiaside	92-106	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	39-44
21361037-1	2010	This study is to investigate the effects of concentration, intestinal section, pH, paracellular route, substrate/inhibitor of enzyme (CYP3A) and proteins (P-gp, MRP2, SGL1) on the absorption of forsythoside A.	forsythiaside	194-208	phosphoglycolate phosphatase	Rattus norvegicus	155-159
20214575-5	2010	Finally, in vitro testing of selected compounds led to the identification of forsythoside A and (+)-sesamolin as novel AChE inhibitors.	forsythiaside	77-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123
33234322-8	2021	Forsythoside A significantly improved the CD3+, CD4+, and CD8+ T-lymphocyte of infected chickens.	forsythiaside	0-14	CD3d molecule	Gallus gallus	42-45
19938549-0	2009	[Determination of forsythoside A in fructus forsythiae by NIR].	forsythiaside	18-32	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	58-61
15714797-3	2005	The determination of forsythoside A was carried out with YWG-C18 column(4.6 mm x 250 mm,10 microm), using acetonitrile-water-Acetic acid (17:83:0.4) as mobile phase at a flow rate of 1.0 mL x min(-1) and detected at the wavelength 280 nm.	forsythiaside	21-35	CD59 molecule (CD59 blood group)	Homo sapiens	192-198
33799169-0	2021	Forsythiaside a plays an anti-inflammatory role in LPS-induced mastitis in a mouse model by modulating the MAPK and NF-kappaB signaling pathways.	forsythiaside	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
33799169-5	2021	These results indicated that forsythiaside A effectively inhibited LPS-induced mammary inflammation in mice by attenuating the activation of the NF-kappaB and p38 MAPK signaling pathways.	forsythiaside	29-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
33799169-5	2021	These results indicated that forsythiaside A effectively inhibited LPS-induced mammary inflammation in mice by attenuating the activation of the NF-kappaB and p38 MAPK signaling pathways.	forsythiaside	29-44	mitogen-activated protein kinase 14	Mus musculus	159-167
33234322-8	2021	Forsythoside A significantly improved the CD3+, CD4+, and CD8+ T-lymphocyte of infected chickens.	forsythiaside	0-14	T-cell surface glycoprotein CD4	Gallus gallus	48-51
33234322-8	2021	Forsythoside A significantly improved the CD3+, CD4+, and CD8+ T-lymphocyte of infected chickens.	forsythiaside	0-14	CD8a molecule	Gallus gallus	58-61
34933162-0	2022	Forsythiaside A alleviates methotrexate-induced intestinal mucositis in rats by modulating the NLRP3 signaling pathways.	forsythiaside	0-15	NLR family, pyrin domain containing 3	Rattus norvegicus	95-100
34731296-8	2021	As a result, we are showing that forsythiaside A is the most stable molecule and it is likely to possess the highest inhibitory effect against SARS-CoV-2 Mpro.	forsythiaside	33-48	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	154-158
35533916-14	2022	The combined administration of peimine, peiminine, and forsythoside A had a strongly inhibitory effects on the W/D weight ratio, total protein (TP) level and the inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and IL-17) level in acute lung injury mice, compared to combined administration of two compounds or individual administration.	forsythiaside	55-69	tumor necrosis factor	Mus musculus	186-195
35533916-14	2022	The combined administration of peimine, peiminine, and forsythoside A had a strongly inhibitory effects on the W/D weight ratio, total protein (TP) level and the inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and IL-17) level in acute lung injury mice, compared to combined administration of two compounds or individual administration.	forsythiaside	55-69	interleukin 6	Mus musculus	197-201
35533916-14	2022	The combined administration of peimine, peiminine, and forsythoside A had a strongly inhibitory effects on the W/D weight ratio, total protein (TP) level and the inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and IL-17) level in acute lung injury mice, compared to combined administration of two compounds or individual administration.	forsythiaside	55-69	interleukin 1 alpha	Mus musculus	203-211
35533916-14	2022	The combined administration of peimine, peiminine, and forsythoside A had a strongly inhibitory effects on the W/D weight ratio, total protein (TP) level and the inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and IL-17) level in acute lung injury mice, compared to combined administration of two compounds or individual administration.	forsythiaside	55-69	interleukin 17A	Mus musculus	217-222
35533916-17	2022	CONCLUSION: The combined administration of peimine, peiminine, and forsythoside A ameliorated inflammatory response in acute lung injury mice induced by LPS in a synergistic manner, the mechanism may be related to the dampening of the TLR4/MAPK/NF-kappaB signaling pathway and IL-17 activation.	forsythiaside	67-81	toll-like receptor 4	Mus musculus	235-239
35533916-17	2022	CONCLUSION: The combined administration of peimine, peiminine, and forsythoside A ameliorated inflammatory response in acute lung injury mice induced by LPS in a synergistic manner, the mechanism may be related to the dampening of the TLR4/MAPK/NF-kappaB signaling pathway and IL-17 activation.	forsythiaside	67-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	245-254
35533916-17	2022	CONCLUSION: The combined administration of peimine, peiminine, and forsythoside A ameliorated inflammatory response in acute lung injury mice induced by LPS in a synergistic manner, the mechanism may be related to the dampening of the TLR4/MAPK/NF-kappaB signaling pathway and IL-17 activation.	forsythiaside	67-81	interleukin 17A	Mus musculus	277-282
35623173-2	2022	Forsythiaside A (FTA), isolated from the traditional Chinese medicine Forsythiae Fructus (Lian Qiao), is a natural hepatoprotective agent.	forsythiaside	0-15	farnesyltransferase, CAAX box, alpha	Mus musculus	17-20
35346677-4	2022	Results showed that, among the main ingredients in the leaves, forsythoside A showed the strongest docking affinities with the proteins SARS-CoV-2-RBD-hACE2 of COVID-19 and its variants (Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617)), as well as neuropilin-1 (NRP1), and SARS-CoV-2 main protease (MPro) to interfere coronavirus entering into the human body.	forsythiaside	63-77	angiotensin converting enzyme 2	Homo sapiens	151-156
35346677-4	2022	Results showed that, among the main ingredients in the leaves, forsythoside A showed the strongest docking affinities with the proteins SARS-CoV-2-RBD-hACE2 of COVID-19 and its variants (Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617)), as well as neuropilin-1 (NRP1), and SARS-CoV-2 main protease (MPro) to interfere coronavirus entering into the human body.	forsythiaside	63-77	neuropilin 1	Homo sapiens	253-265
35346677-4	2022	Results showed that, among the main ingredients in the leaves, forsythoside A showed the strongest docking affinities with the proteins SARS-CoV-2-RBD-hACE2 of COVID-19 and its variants (Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617)), as well as neuropilin-1 (NRP1), and SARS-CoV-2 main protease (MPro) to interfere coronavirus entering into the human body.	forsythiaside	63-77	neuropilin 1	Homo sapiens	267-271
35346677-7	2022	In addition, forsythoside A reduced ROS production in AGEs-induced EA.hy926 cells, maintained endothelial integrity, and bound closely to protein profilin-1 (PFN1) receptor.	forsythiaside	13-27	profilin 1	Homo sapiens	146-156
35346677-7	2022	In addition, forsythoside A reduced ROS production in AGEs-induced EA.hy926 cells, maintained endothelial integrity, and bound closely to protein profilin-1 (PFN1) receptor.	forsythiaside	13-27	profilin 1	Homo sapiens	158-162