PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25794333-3	2015	Methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (SERT and DAT, respectively).	methylone	0-9	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	120-124
33609514-6	2021	It was also observed an enantioselectivity in the binding to P-glycoprotein (P-gp), another efflux protein, being the R-(-)-pentedrone and S-(-)-methylone the most transported enantiomeric compounds.	methylone	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	61-75
33609514-6	2021	It was also observed an enantioselectivity in the binding to P-glycoprotein (P-gp), another efflux protein, being the R-(-)-pentedrone and S-(-)-methylone the most transported enantiomeric compounds.	methylone	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
33609514-7	2021	These results were confirmed, in silico, by docking studies, revealing that R-(-)-pentedrone is the enantiomer with highest affinity to MRP1 and S-(-)-methylone and R-(-)-pentedrone are the enantiomers with highest affinity to P-gp.	methylone	145-160	ATP binding cassette subfamily B member 1	Homo sapiens	227-231
33609514-8	2021	In conclusion, our data demonstrated that pentedrone and methylone present enantioselectivity in their cytotoxicity, which seems to involve, different oxidative reactivity as well as different affinity to the P-gp and MRP1 that together with GSH, play a protective role.	methylone	57-66	ATP binding cassette subfamily B member 1	Homo sapiens	209-213
33609514-8	2021	In conclusion, our data demonstrated that pentedrone and methylone present enantioselectivity in their cytotoxicity, which seems to involve, different oxidative reactivity as well as different affinity to the P-gp and MRP1 that together with GSH, play a protective role.	methylone	57-66	ATP binding cassette subfamily C member 1	Homo sapiens	218-222
31934604-9	2019	Tissue samples collected after treatment on the sixth week indicate that chronic exposure to methylone reduced UCP1 expression in SKM and BAT of the female rats.	methylone	93-102	uncoupling protein 1	Rattus norvegicus	111-115
25794333-8	2015	Administration of the selective D1 receptor antagonist SCH 23390 and the D2 receptor antagonist raclopride reduced methylone-induced hyperthermia, but these drugs also had hypothermic effects in saline-treated mice, albeit to a smaller extent than the effects observed in methylone-treated mice.	methylone	115-124	dopamine receptor D1	Mus musculus	32-43
25794333-8	2015	Administration of the selective D1 receptor antagonist SCH 23390 and the D2 receptor antagonist raclopride reduced methylone-induced hyperthermia, but these drugs also had hypothermic effects in saline-treated mice, albeit to a smaller extent than the effects observed in methylone-treated mice.	methylone	115-124	dopamine receptor D2	Mus musculus	73-84
25794333-9	2015	In contradistinction to 3,4-methylenedioxymethamphetamine, which induces its toxicity through SERT and DAT, these data indicate that DAT, but not SERT, is strongly associated with the lethal toxicity produced by methylone, which did not seem to be dependent on the hyperthermic effects of methylone.	methylone	212-221	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	133-136
25794333-3	2015	Methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (SERT and DAT, respectively).	methylone	0-9	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	129-132
25794333-9	2015	In contradistinction to 3,4-methylenedioxymethamphetamine, which induces its toxicity through SERT and DAT, these data indicate that DAT, but not SERT, is strongly associated with the lethal toxicity produced by methylone, which did not seem to be dependent on the hyperthermic effects of methylone.	methylone	289-298	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	133-136
25794333-10	2015	DAT is therefore a strong candidate molecule for interventions aimed at preventing acute neurotoxic and lethal effects of methylone.	methylone	122-131	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	0-3
25794333-7	2015	By contrast, only a slight diminution in the hyperthermic effects of methylone was observed in DAT KO mice, whereas a slight enhancement of these effects was observed in SERT KO mice.	methylone	69-78	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	95-98
25626880-15	2015	Methylone (METHY) and mephedrone (MEPH; b), like METH, are substrates for the DAT but release DA from cytoplasmic pools selectively.	methylone	0-9	solute carrier family 6 member 3	Homo sapiens	78-81
25626880-15	2015	Methylone (METHY) and mephedrone (MEPH; b), like METH, are substrates for the DAT but release DA from cytoplasmic pools selectively.	methylone	11-16	solute carrier family 6 member 3	Homo sapiens	78-81
23099177-7	2013	Methylone had little effect on behavior or neurotransmitter levels in mice but produced a widespread depletion of 5-HT and 5-HTT levels in rats.	methylone	0-9	huntingtin	Mus musculus	125-128
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	106-115	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	39-45
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	106-115	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	251-257
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	165-174	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	39-45
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	165-174	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	251-257
23545806-3	2013	Using in vitro studies, CYP2D6 was determined to be the primary enzyme that metabolizes methylone, with minor contributions from CYP1A2, CYP2B6, and CYP2C19.	methylone	88-97	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	24-30