PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33086897-0	2020	Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors.	imidazopyridine	79-94	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	98-102
33738077-3	2021	Detailed subsequently are efforts to identify a structurally differentiated IDO1 inhibitor via the pursuit of a variety of heterocyclic isosteres, leading to the discovery of highly potent, imidazopyridine-containing IDO1 inhibitors.	imidazopyridine	190-205	indoleamine 2,3-dioxygenase 1	Homo sapiens	76-80
33738077-3	2021	Detailed subsequently are efforts to identify a structurally differentiated IDO1 inhibitor via the pursuit of a variety of heterocyclic isosteres, leading to the discovery of highly potent, imidazopyridine-containing IDO1 inhibitors.	imidazopyridine	190-205	indoleamine 2,3-dioxygenase 1	Homo sapiens	217-221
33391507-3	2021	W2014-S with pharmacophore structure of imidazopyridine, which was firstly reported to be utilized in STAT3 inhibitor discovery, was screened out as a potent STAT3 inhibitor from a library of small molecules.	imidazopyridine	40-55	signal transducer and activator of transcription 3	Homo sapiens	102-107
33391507-3	2021	W2014-S with pharmacophore structure of imidazopyridine, which was firstly reported to be utilized in STAT3 inhibitor discovery, was screened out as a potent STAT3 inhibitor from a library of small molecules.	imidazopyridine	40-55	signal transducer and activator of transcription 3	Homo sapiens	158-163
34055224-0	2021	Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.	imidazopyridine	48-64	programmed cell death 1	Homo sapiens	68-72
34055224-0	2021	Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.	imidazopyridine	48-64	CD274 molecule	Homo sapiens	73-78
33086897-6	2020	We synthesised imidazopyridine derivatives as novel TAK1 inhibitors, which have 2-cyanoacrylamide moiety that can form reversible covalent bonding.	imidazopyridine	15-30	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	52-56
33116593-0	2020	A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/beta-catenin Signaling.	imidazopyridine	8-23	catenin beta 1	Homo sapiens	99-111
33153423-1	2021	The present protocol is a simple and eco-friendly approach for the one-pot procedure by using a sonicator for the synthesis of substituted imidazopyridines ranging from important feedstock"s like styrene promoted by NBS.	imidazopyridine	139-155	nibrin	Homo sapiens	216-219
28800461-7	2017	The western blot assay indicated that 1i is more effective than HS-173, an imidazopyridine-based PI3Ka inhibitor, in reducing the levels of phospho-Akt.	imidazopyridine	75-90	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	97-102
32806205-2	2020	The coordination effect of Lewis acid was the dominant factor controlling the regioselective addition of silyl radical to imidazopyridines, and the corresponding C-5 silylated imidazo[1,2-a]pyridines were obtained in moderate to high yields with a broad substrate scope.	imidazopyridine	122-138	complement C5	Homo sapiens	162-165
31422171-5	2019	In this study, we performed the one-step synthesis of water-dispersible ultra-small iron oxide nanoparticles (USPIONs) and combine them with an imidazopyridine based TSPO ligand and a fluorescent dye.	imidazopyridine	144-159	translocator protein	Homo sapiens	166-170
30261753-0	2018	Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1.	imidazopyridine	6-21	signal transducer and activator of transcription 3	Homo sapiens	33-38
30261753-0	2018	Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1.	imidazopyridine	6-21	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	63-68
30261753-3	2018	Novel imidazopyridine compounds were synthesized to evaluate the inhibition of STAT3 at Y705.	imidazopyridine	6-21	signal transducer and activator of transcription 3	Homo sapiens	79-84
32806205-0	2020	Selective C-5 Oxidative Radical Silylation of Imidazopyridines Promoted by Lewis Acid.	imidazopyridine	46-62	complement C5	Homo sapiens	10-13
32781957-4	2020	There are several natural and synthetic FASN inhibitors reported in the literature, a few examples are GSK 2194069 (7.7 nM), imidazopyridine (16 nM), epigallocatechin-3-gallate (42.0 microg/ml) and platensimycin (300 nM) but except for TVB-2640, none of the aforementioned inhibitors have made into clinical trials.	imidazopyridine	125-140	fatty acid synthase	Homo sapiens	40-44
30422629-5	2018	Herein, we describe imidazopyridines represented by PF-06424439 (1) and 2 as long residence time inhibitors of DGAT2.	imidazopyridine	20-36	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	111-116
30422629-9	2018	A binding assay utilizing 125I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2.	imidazopyridine	39-54	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	113-118
30422629-9	2018	A binding assay utilizing 125I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2.	imidazopyridine	86-101	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	113-118
30422629-9	2018	A binding assay utilizing 125I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2.	imidazopyridine	86-101	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	294-299
30422629-9	2018	A binding assay utilizing 125I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2.	imidazopyridine	266-282	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	113-118
30422629-10	2018	Taken together, imidazopyridines may thus represent a promising lead series for the development of DGAT2 inhibitors that display an unprecedented combination of potency, selectivity, and in vivo efficacy.	imidazopyridine	16-32	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	99-104
30132331-0	2018	Visible-Light-Promoted C(sp3)-C(sp2) Cross-Dehydrogenative Coupling of Tertiary Amine with Imidazopyridine.	imidazopyridine	91-106	Sp2 transcription factor	Homo sapiens	30-35
30088508-0	2018	Palladium-catalyzed oxidative C-H/C-H cross-coupling of imidazopyridines with azoles.	imidazopyridine	56-72	churchill domain containing 1	Homo sapiens	30-37
30088508-1	2018	An effective palladium-catalyzed oxidative C-H/C-H cross-coupling of imidazopyridines with azoles using air as the oxidant has been developed.	imidazopyridine	69-85	churchill domain containing 1	Homo sapiens	43-50
29243330-0	2018	Direct, Metal-free C(sp2 )-H Chalcogenation of Indoles and Imidazopyridines with Dichalcogenides Catalysed by KIO3.	imidazopyridine	59-75	Sp2 transcription factor	Homo sapiens	19-24
28678513-1	2017	A hitherto unreported aminomethylation occurs at C-3 of imidazopyridines with morpholine in the presence of (diacetoxyiodo)benzene at ambient temperature in short reaction times.	imidazopyridine	56-72	complement C3	Homo sapiens	49-52
28728105-0	2017	Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.	imidazopyridine	13-29	beta-secretase 1	Homo sapiens	91-96
28728105-4	2017	We designed a series of imidazopyridines-based compounds bearing phthalimide moieties as inhibitors of BACE1.	imidazopyridine	24-40	beta-secretase 1	Homo sapiens	103-108
28728105-6	2017	Evaluating the BACE1 inhibitory effects of the synthesized compounds revealed that introducing an aminocyclohexyl moiety in the imidazopyridine core resulted in a significant improvement in its BACE1 inhibitory potential.	imidazopyridine	128-143	beta-secretase 1	Homo sapiens	15-20
28728105-6	2017	Evaluating the BACE1 inhibitory effects of the synthesized compounds revealed that introducing an aminocyclohexyl moiety in the imidazopyridine core resulted in a significant improvement in its BACE1 inhibitory potential.	imidazopyridine	128-143	beta-secretase 1	Homo sapiens	194-199
28728105-8	2017	Molecular docking revealed that the nitrogen atom of imidazopyridines and the oxygen atom of the phenoxypropyl linker were involved in hydrogen bound interactions with Asp228 and Asp32 of BACE1 active site, respectively.	imidazopyridine	53-69	beta-secretase 1	Homo sapiens	188-193
28830649-0	2017	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.	imidazopyridine	21-36	tyrosine kinase 2	Homo sapiens	79-83
28830649-1	2017	Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1.	imidazopyridine	38-53	tyrosine kinase 2	Homo sapiens	84-88
28470069-1	2017	3-Cyanomethylated imidazopyridines were synthesized via a visible light-promoted reaction of imidazopyridines with bromoacetonitrile or iodoacetonitrile catalyzed by fac-Ir(ppy)3 under mild conditions.	imidazopyridine	18-34	FA complementation group C	Homo sapiens	166-169
28650506-2	2017	This communication discloses an oxidative radical dual sp2/sp3 C-H thiolation strategy for the coupling of imidazopyridines with ethers or alkanes using elemental sulphur.	imidazopyridine	107-123	Sp2 transcription factor	Homo sapiens	55-58
28650506-2	2017	This communication discloses an oxidative radical dual sp2/sp3 C-H thiolation strategy for the coupling of imidazopyridines with ethers or alkanes using elemental sulphur.	imidazopyridine	107-123	Sp3 transcription factor	Homo sapiens	59-62
27992115-2	2017	This heteroarene   peptide bond stacking was supported by a co-crystal structure of an imidazopyridine ligand with hCatL.	imidazopyridine	87-102	cathepsin L	Homo sapiens	115-120
27607364-6	2016	Moreover, bicyclic ring structures such as imidazopyridine, pyrazolopyrimidine, and phenylpurine will be highlighted as promising scaffolds for TSPO ligands.	imidazopyridine	43-58	translocator protein	Homo sapiens	144-148
30108796-2	2017	Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated with imidazopyridine 1 can be mitigated with small structural modifications, and is thus not mechanism related.	imidazopyridine	56-71	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	78-83
28043720-0	2017	Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.	imidazopyridine	13-28	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	50-55
28043720-0	2017	Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.	imidazopyridine	13-28	sarcosine dehydrogenase	Homo sapiens	86-89
28043720-2	2017	A series of imidazopyridine derivatives were designed and synthesized according to the established docking studies as possible c-Met inhibitors.	imidazopyridine	12-27	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	127-132
28043720-3	2017	Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochemical enzymatic screens and cellular pharmacology studies.	imidazopyridine	14-29	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	78-83
28043720-6	2017	These findings indicated that the novel imidazopyridine derivative compound 7g was a potential c-Met inhibitor deserving further investigation for cancer treatment.	imidazopyridine	40-55	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	95-100
27979595-2	2017	Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.	imidazopyridine	82-98	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	34-41
27979595-2	2017	Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.	imidazopyridine	82-98	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	139-146
27213958-0	2016	Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase.	imidazopyridine	0-15	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	74-102
27399688-2	2016	In order to develop highly selective and active ligands with a high affinity for TSPO, imidazopyridine-based TSPO ligand (CB256, 3) was prepared as the precursor.	imidazopyridine	87-102	translocator protein	Homo sapiens	81-85
27399688-2	2016	In order to develop highly selective and active ligands with a high affinity for TSPO, imidazopyridine-based TSPO ligand (CB256, 3) was prepared as the precursor.	imidazopyridine	87-102	translocator protein	Homo sapiens	109-113
26856922-0	2016	Synthesis of carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives as new potential PET tracers for imaging of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).	imidazopyridine	31-46	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	129-175
27117431-5	2016	The crystal structure illustrates that the pyrazole and imidazopyridine rings of KY-04045 are sufficient for mediating PAK4 hinge loop interaction.	imidazopyridine	56-71	p21 (RAC1) activated kinase 4	Homo sapiens	119-123
26856922-0	2016	Synthesis of carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives as new potential PET tracers for imaging of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).	imidazopyridine	31-46	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	177-181
25529740-3	2015	Further structural optimization on type II inhibitors by truncation of the imidazonaphthyridinone core and incorporation of an N-phenyl cyclopropane-1,1-dicarboxamide pharmacophore led to the discovery of novel imidazopyridine-based c-Met kinase inhibitors, displaying nanomolar enzyme inhibitory activity and improved Met kinase selectivity.	imidazopyridine	211-226	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	233-238
26774655-4	2016	With a hypothesis that a planar conformation between the core and the 6-heteroaryl ring will allow for the accommodation of larger 5"-substituents in a hydrophobic area under P-loop, SAR efforts focused on 5"-alkoxy heteroaryl rings at the 6-position of imidazopyridine and imidazopyridazine cores that have the same dihedral angle of zero degrees.	imidazopyridine	254-269	sarcosinemia autosomal recessive	Mus musculus	183-186
26490333-3	2016	The radio-iodinated imidazopyridine derivative (123)I-ABC577 was designed as a candidate for a novel amyloid-beta imaging agent.	imidazopyridine	20-35	amyloid beta precursor protein	Homo sapiens	101-113
26196520-3	2015	Subsequently, we performed in silico mode-of-action analysis and predicted that the synthesized imidazopyridines targets Phospholipase A2 (PLA2).	imidazopyridine	96-112	phospholipase A2 group IB	Homo sapiens	121-137
26196520-3	2015	Subsequently, we performed in silico mode-of-action analysis and predicted that the synthesized imidazopyridines targets Phospholipase A2 (PLA2).	imidazopyridine	96-112	phospholipase A2 group IB	Homo sapiens	139-143
26580609-0	2015	An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors.	imidazopyridine	74-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	94-99
26580609-2	2015	Nowadays, a group of imidazopyridines as B-Raf kinase inhibitors have been reported.	imidazopyridine	21-37	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	41-46
26580609-8	2015	These results are expected to understand the binding between B-Raf and imidazopyridines and provide some useful information to design potential B-Raf inhibitors.	imidazopyridine	71-87	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	61-66
26580609-8	2015	These results are expected to understand the binding between B-Raf and imidazopyridines and provide some useful information to design potential B-Raf inhibitors.	imidazopyridine	71-87	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	144-149
26349027-0	2015	Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).	imidazopyridine	30-45	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	66-98
26349027-0	2015	Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).	imidazopyridine	30-45	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	100-105
26349027-1	2015	The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.	imidazopyridine	51-66	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	87-119
26349027-1	2015	The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.	imidazopyridine	51-66	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	121-126
26121643-5	2015	Imidazopyridines have recently been shown to possess Akt kinase inhibitory activity; thus in this study, we investigated the inhibitory effect of novel imidazopyridine derivatives HIMP, M-MeI, OMP, and EtOP on different human castration-resistant PCa cells.	imidazopyridine	0-16	AKT serine/threonine kinase 1	Homo sapiens	53-56
26070068-2	2015	In the present study, we characterized some imidazopyridine compounds as GPR4 modulators that modify GPR4 receptor function.	imidazopyridine	44-59	G protein-coupled receptor 4	Homo sapiens	73-77
26070068-2	2015	In the present study, we characterized some imidazopyridine compounds as GPR4 modulators that modify GPR4 receptor function.	imidazopyridine	44-59	G protein-coupled receptor 4	Homo sapiens	101-105
26070068-4	2015	Imidazopyridine compounds inhibited the moderately acidic pH-induced SRE activity only in GPR4-expressing cells.	imidazopyridine	0-15	G protein-coupled receptor 4	Homo sapiens	90-94
26070068-6	2015	We further compared the inhibition property of the imidazopyridine compound with psychosine, which has been shown to selectively inhibit actions induced by proton-sensing GPCRs, including GPR4.	imidazopyridine	51-66	G protein-coupled receptor 4	Homo sapiens	188-192
26070068-8	2015	On the other hand, the imidazopyridine compound almost completely inhibited acidic pH-induced action in mutant GPR4.	imidazopyridine	23-38	G protein-coupled receptor 4	Homo sapiens	111-115
26070068-9	2015	We conclude that some imidazopyridine compounds show specificity to GPR4 as negative allosteric modulators with a different action mode from psychosine, an antagonist susceptible to histidine residues, and are useful for characterizing GPR4-mediated acidic pH-induced biological actions.	imidazopyridine	22-37	G protein-coupled receptor 4	Homo sapiens	68-72
26070068-9	2015	We conclude that some imidazopyridine compounds show specificity to GPR4 as negative allosteric modulators with a different action mode from psychosine, an antagonist susceptible to histidine residues, and are useful for characterizing GPR4-mediated acidic pH-induced biological actions.	imidazopyridine	22-37	G protein-coupled receptor 4	Homo sapiens	236-240
25616581-1	2015	OBJECTIVE: We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [(11)C]CB184 and [(11)C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor.	imidazopyridine	56-72	translocator protein	Rattus norvegicus	73-77
25765758-0	2015	Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.	imidazopyridine	79-94	fms related receptor tyrosine kinase 3	Homo sapiens	106-110
25577039-4	2015	The SAR knowledge gleaned in the optimization of scaffolds containing benzoxazoles was parlayed toward the identification of potent NS5A inhibitors containing other heteroaromatic replacements such as indoles and imidazopyridines.	imidazopyridine	213-229	sarcosine dehydrogenase	Homo sapiens	4-7
25431995-4	2015	Recently, we have designed and synthesized a series of novel imidazopyridine and imidazopyrazine derivatives that inhibit Mnk1/2 kinases with a potency in the nanomolar to micromolar range.	imidazopyridine	61-76	MAPK interacting serine/threonine kinase 1	Homo sapiens	122-128
24479199-0	2010	ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4 Here we report the first highly selective CYP3A4 inhibitor optimized from an initial lead with  30-fold selectivity over CYP3A5 to yield a series of compounds with greater than 1000-fold selectivity.	imidazopyridine	24-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-100
25069996-5	2014	The results of the present investigation are essential for the design of new imidazopyridine bifunctional chelate ligands targeted to TSPO.	imidazopyridine	77-92	translocator protein	Homo sapiens	134-138
25205195-1	2014	We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors.	imidazopyridine	62-77	AKT serine/threonine kinase 1	Homo sapiens	145-148
24909730-0	2014	QSAR models for thiophene and imidazopyridine derivatives inhibitors of the Polo-Like Kinase 1.	imidazopyridine	30-45	polo like kinase 1	Homo sapiens	76-94
25231248-1	2015	PURPOSE: The in vivo binding parameters of the novel imidazopyridine TSPO ligand [(18)F]PBR102 were assessed and compared with those of [(18)F]PBR111 in a rodent model of neuroinflammation.	imidazopyridine	53-68	translocator protein	Rattus norvegicus	69-73
24909730-1	2014	The inhibitory activity of 103 thiophene and 33 imidazopyridine derivatives against Polo-Like Kinase 1 (PLK1) expressed as pIC50 (-logIC50) was predicted by QSAR modeling.	imidazopyridine	48-63	polo like kinase 1	Homo sapiens	84-102
24909730-1	2014	The inhibitory activity of 103 thiophene and 33 imidazopyridine derivatives against Polo-Like Kinase 1 (PLK1) expressed as pIC50 (-logIC50) was predicted by QSAR modeling.	imidazopyridine	48-63	polo like kinase 1	Homo sapiens	104-108
24479199-0	2010	ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4 Here we report the first highly selective CYP3A4 inhibitor optimized from an initial lead with  30-fold selectivity over CYP3A5 to yield a series of compounds with greater than 1000-fold selectivity.	imidazopyridine	24-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-101
24479199-0	2010	ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4 Here we report the first highly selective CYP3A4 inhibitor optimized from an initial lead with  30-fold selectivity over CYP3A5 to yield a series of compounds with greater than 1000-fold selectivity.	imidazopyridine	24-40	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	223-229
24479199-1	2010	During our medicinal chemistry and biology effort pursued under our existing LRH1 inverse agonist Extended Characterization (EC) project, we identified several compounds belonging to the imidazopyridine scaffold with activity against the cytochrome enzymes.	imidazopyridine	187-202	purinergic receptor P2X 5	Homo sapiens	77-81
24685494-0	2014	Synthesis of [11C]PBR170, a novel imidazopyridine, for imaging the translocator protein with PET.	imidazopyridine	34-49	translocator protein	Homo sapiens	67-87
24931274-0	2014	Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-beta imaging in Alzheimer"s disease.	imidazopyridine	60-75	amyloid beta precursor protein	Homo sapiens	92-104
24922544-0	2014	Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.	imidazopyridine	40-55	cell division cycle 25C	Homo sapiens	86-91
24922544-4	2014	In this article, refinement of the initial hit XDW-1 by synthesis and screening of a focused compound library led to the identification of a novel set of imidazopyridine derivatives as potent CDC25 inhibitors.	imidazopyridine	154-169	cell division cycle 25C	Homo sapiens	192-197
23085493-0	2013	A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway.	imidazopyridine	8-23	mechanistic target of rapamycin kinase	Homo sapiens	134-138
24102269-5	2013	We herein report the design and synthesis of new imidazopyridine based potent dual inhibitors of HIF-1alpha and STAT3 pathways.	imidazopyridine	49-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
24102269-5	2013	We herein report the design and synthesis of new imidazopyridine based potent dual inhibitors of HIF-1alpha and STAT3 pathways.	imidazopyridine	49-64	signal transducer and activator of transcription 3	Homo sapiens	112-117
24021463-3	2013	This molecule also exhibited reduced rat retinal exposures relative to a previously studied imidazo-pyridine-containing NAMPT inhibitor.	imidazopyridine	92-108	nicotinamide phosphoribosyltransferase	Rattus norvegicus	120-125
24021463-5	2013	The compound also exhibited only minimal effects on in vivo NAD levels in mice, and these changes were considerably less profound than those produced by an imidazo-pyridine-containing NAMPT inhibitor.	imidazopyridine	156-172	nicotinamide phosphoribosyltransferase	Mus musculus	184-189
23752769-1	2013	A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new (99m)Tc or (188/186)Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively.	imidazopyridine	34-49	translocator protein	Homo sapiens	82-86
24282133-0	2014	Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands.	imidazopyridine	108-123	G protein-coupled receptor 166 pseudogene	Homo sapiens	124-128
22929971-1	2013	We synthesized a novel imidazopyridine analogue, a PI3Kalpha inhibitor HS-173 and investigated anti-cancer capacity in human cancer cells.	imidazopyridine	23-38	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	51-60
24900571-1	2013	Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described.	imidazopyridine	7-22	fatty acid synthase	Rattus norvegicus	43-62
24900571-1	2013	Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described.	imidazopyridine	7-22	fatty acid synthase	Rattus norvegicus	64-68
22264486-0	2012	Imidazopyridines as selective CYP3A4 inhibitors.	imidazopyridine	0-16	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
22765895-4	2012	Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.	imidazopyridine	54-69	sarcosine dehydrogenase	Homo sapiens	17-20
22765895-4	2012	Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.	imidazopyridine	54-69	mechanistic target of rapamycin kinase	Homo sapiens	159-163
24900520-0	2012	Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight.	imidazopyridine	30-45	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	66-71
22672803-0	2012	Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3beta inhibitors.	imidazopyridine	53-69	glycogen synthase kinase 3 beta	Mus musculus	96-104
22672803-1	2012	Design, synthesis and biological evaluation of the imidazopyridine analogs as novel GSK3beta inhibitors for treatment of type 2 diabetes mellitus are described.	imidazopyridine	51-66	glycogen synthase kinase 3 beta	Mus musculus	84-92
22672803-3	2012	The structure-activity relationship (SAR) of the imidazopyridine analogs and the binding mode of analog 23 in the catalytic domain of GSK3beta, based on our X-ray crystallography study, are described.	imidazopyridine	49-64	glycogen synthase kinase 3 beta	Mus musculus	134-142
22155744-1	2012	Potentiation of anti-breast cancer activity of an imidazopyridine-based PI3Kalpha inhibitor, HS-104, was investigated in human breast cancer cells.	imidazopyridine	50-65	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	72-81
21420860-0	2011	Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.	imidazopyridine	0-15	cannabinoid receptor 2	Rattus norvegicus	16-19
21420860-0	2011	Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.	imidazopyridine	0-15	cannabinoid receptor 2	Rattus norvegicus	46-49
21420860-0	2011	Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.	imidazopyridine	0-15	cannabinoid receptor 1	Rattus norvegicus	50-53
19539471-1	2009	A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described.	imidazopyridine	82-98	dipeptidyl peptidase 4	Homo sapiens	16-21
20660795-9	2010	In a small-scale screen, a series of imidazopyridine compounds was tested to identify the small molecules that modulate eIF5A-mediated phagocytic activity.	imidazopyridine	37-52	eukaryotic translation initiation factor 5A	Mus musculus	120-125
19589677-0	2009	Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.	imidazopyridine	0-15	polo-like kinase 1	Rattus norvegicus	52-68
19589677-0	2009	Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.	imidazopyridine	0-15	polo-like kinase 1	Rattus norvegicus	70-73
19589677-1	2009	A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors.	imidazopyridine	17-32	polo-like kinase 1	Rattus norvegicus	61-65
19952121-1	2009	CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.	imidazopyridine	67-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-35
19952121-1	2009	CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.	imidazopyridine	67-82	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-42
19539471-2	2009	Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34.	imidazopyridine	71-86	dipeptidyl peptidase 4	Homo sapiens	30-35
18282708-0	2008	Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1" substituents.	imidazopyridine	140-155	ADAM metallopeptidase domain 17	Homo sapiens	53-98
19509149-1	2009	PURPOSE: We designed and synthesized CUDC-305, an HSP90 inhibitor of the novel imidazopyridine class.	imidazopyridine	79-94	heat shock protein 90 alpha family class A member 1	Homo sapiens	50-55
18178668-1	2008	Imidazopyridine derivates were recently shown to be a novel class of selective and arginine-competitive inhibitors of inducible nitric-oxide synthase (iNOS), and 2-[2-(4-methoxypyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) was found to have very high selectivity in enzymatic and cellular models ( Mol Pharmacol 69: 328-337, 2006 ).	imidazopyridine	0-15	nitric oxide synthase 2	Homo sapiens	118-149
18178668-1	2008	Imidazopyridine derivates were recently shown to be a novel class of selective and arginine-competitive inhibitors of inducible nitric-oxide synthase (iNOS), and 2-[2-(4-methoxypyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) was found to have very high selectivity in enzymatic and cellular models ( Mol Pharmacol 69: 328-337, 2006 ).	imidazopyridine	0-15	nitric oxide synthase 2	Homo sapiens	151-155
18809672-0	2008	Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.	imidazopyridine	20-35	poly(ADP-ribose) polymerase 1	Homo sapiens	108-135
18809672-0	2008	Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.	imidazopyridine	20-35	poly(ADP-ribose) polymerase 1	Homo sapiens	137-141
19133222-4	2008	Its imidazopyridine structure interacts with CCR5 and induces a co-receptor conformation that prevents glycoproteins binding to the viral envelope.	imidazopyridine	4-19	C-C motif chemokine receptor 5	Homo sapiens	45-49
18282708-0	2008	Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1" substituents.	imidazopyridine	140-155	ADAM metallopeptidase domain 17	Homo sapiens	100-104
18243692-0	2008	Imidazopyridines: a novel class of hNav1.7 channel blockers.	imidazopyridine	0-16	neuron navigator 1	Homo sapiens	35-40
17722875-3	2007	For the mentioned purpose, imidazopyridine and imidazopyrimidine compounds 5-20 were synthesized, and their affinity for PBR was determined.	imidazopyridine	27-42	translocator protein	Homo sapiens	121-124
16700898-6	2006	Pantoprazole and tenatoprazole, a novel proton pump inhibitor which has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors, are activated more slowly than other proton pump inhibitors but their inhibition is resistant to reversal.	imidazopyridine	75-90	ATPase H+/K+ transporting subunit alpha	Homo sapiens	40-51
16368897-0	2006	In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.	imidazopyridine	38-53	nitric oxide synthase 2	Rattus norvegicus	173-204
10508441-3	1999	Substitution on the imidazopyridine nucleus at position 8 with lipophilic substituents and the presence of one chlorine atom at the para position of the phenyl ring at C(2) are crucial features for high binding affinity and selectivity toward PBR.	imidazopyridine	20-35	translocator protein	Homo sapiens	243-246
9433391-1	1997	BACKGROUND: Zolpidem is a short-acting imidazopyridine hypnotic drug that is metabolized mainly by CYP3A4.	imidazopyridine	39-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105
8863805-1	1996	Alpidem (1), the anxiolytic imidazopyridine, has nanomolar binding affinity for both the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor (PBR).	imidazopyridine	28-43	cannabinoid receptor 1	Homo sapiens	89-120
8863805-1	1996	Alpidem (1), the anxiolytic imidazopyridine, has nanomolar binding affinity for both the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor (PBR).	imidazopyridine	28-43	cannabinoid receptor 1	Homo sapiens	122-125
8863805-1	1996	Alpidem (1), the anxiolytic imidazopyridine, has nanomolar binding affinity for both the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor (PBR).	imidazopyridine	28-43	translocator protein	Homo sapiens	135-169
8863805-1	1996	Alpidem (1), the anxiolytic imidazopyridine, has nanomolar binding affinity for both the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor (PBR).	imidazopyridine	28-43	translocator protein	Homo sapiens	171-174
33971490-4	2021	Series of imidazopyrazines, imidazopyridazines and imidazopyridines derivatives were synthesized and evaluated as MNK1/2 inhibitors.	imidazopyridine	51-67	MAPK interacting serine/threonine kinase 1	Homo sapiens	114-120
15012992-2	2004	A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.	imidazopyridine	13-29	kinase insert domain receptor	Homo sapiens	72-75
12688761-2	2003	Several synthetic approaches that describe the introduction of a C-3 pyrimidine substituent on the imidazopyridine core via construction of the pyrimidine or Stille coupling are outlined.	imidazopyridine	99-114	complement C3	Homo sapiens	65-68
12643929-0	2003	Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.	imidazopyridine	13-29	leukotriene A4 hydrolase	Mus musculus	66-90
9626922-1	1998	OBJECTIVE: Zolpidem is a short-acting imidazopyridine hypnotic which is biotransformed in humans mainly by CYP3A4.	imidazopyridine	38-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113
8388468-0	1993	Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.	imidazopyridine	50-66	phosphodiesterase 3B	Homo sapiens	0-35
34545902-2	2021	Under the irradiation of a blue LED, a series of C3-perfluoroalkyl-substituted imidazopyridines were synthesized from the corresponding imidazopyridines and perfluoroalkyl iodides in moderate to good yields at room temperature.	imidazopyridine	136-152	small integral membrane protein 10 like 2A	Homo sapiens	32-35
35424560-0	2022	A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization.	imidazopyridine	71-87	Sp3 transcription factor	Homo sapiens	106-109
35424560-0	2022	A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization.	imidazopyridine	71-87	Sp2 transcription factor	Homo sapiens	111-114