PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18558344-5	2008	The transformants showed increase in the content of various isoprenoids such as chlorophyll a, beta-carotene, lutein, antheraxanthin, solanesol and beta-sitosterol, indicating that the DXR reaction is one of the key steps controlling isoprenoid level in tobacco leaves.	Lutein	110-116	1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic	Nicotiana tabacum	185-188
19164258-7	2009	beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations.	Lutein	34-40	interleukin 6	Homo sapiens	93-106
16306311-7	2006	Those with the lowest levels of alpha- and beta-carotene, lutein/zeaxanthin, and total carotenoids were significantly more likely to have increasing IL-6 levels over a period of 2 years.	Lutein	58-64	interleukin 6	Homo sapiens	149-153
16716595-0	2006	Molecular modeling of non-covalent binding of homochiral (3S,3"S)-astaxanthin to matrix metalloproteinase-13 (MMP-13).	Lutein	57-65	matrix metallopeptidase 13	Homo sapiens	81-108
16716595-0	2006	Molecular modeling of non-covalent binding of homochiral (3S,3"S)-astaxanthin to matrix metalloproteinase-13 (MMP-13).	Lutein	57-65	matrix metallopeptidase 13	Homo sapiens	110-116
9075202-5	1997	In contrast, the phenoxyl radicals generated from phenol (by native myeloperoxidase in HL-60 cells or HRP/H2O2 in model systems) effectively oxidized beta-carotene and other carotenoids (canthaxanthin, lutein, lycopene).	Lutein	202-208	myeloperoxidase	Homo sapiens	68-83
15355982-12	2004	These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3"S-meso)-zeaxanthin and dietary (3R,3"R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3"R,6"R)-lutein.	Lutein	196-215	glutathione S-transferase pi 1	Homo sapiens	28-33
15355982-12	2004	These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3"S-meso)-zeaxanthin and dietary (3R,3"R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3"R,6"R)-lutein.	Lutein	196-215	X-box binding protein 1 pseudogene 1	Homo sapiens	48-51
12947436-5	2003	RESULTS: C-reactive protein concentration (dichotomized at the sex-specific 85th percentile) was inversely and significantly associated with concentrations of retinol, retinyl esters, vitamin C, alpha-carotene, beta-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and selenium after adjustment for age, sex, race or ethnicity, education, cotinine concentration, body mass index, leisure-time physical activity, and aspirin use.	Lutein	241-247	C-reactive protein	Homo sapiens	9-27
10856518-10	2000	Pre-treatment with beta-carotene, lutein and lycopene significantly reduced the expression of ICAM-1 by 11, 14, and 18%, respectively.	Lutein	34-40	intercellular adhesion molecule 1	Homo sapiens	94-100
34766659-6	2022	Additionally, LUT suppressed caspase-3 activity, increased anti-inflammatory cytokine-IL-10 level, and reduced pathological lesions in the examined organs of rats cotreated with LUT and DOX.	Lutein	178-181	caspase 3	Rattus norvegicus	29-38
34942193-7	2022	Furthermore, surface plasmon resonance spectroscopy (SPR) data showed that the binding affinity between ApoA-I and beta-carotene >> zeaxanthin > lutein.	Lutein	145-151	apolipoprotein A-I	Mus musculus	104-110
34614244-0	2022	Hyperglycemia-induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS-mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein.	Lutein	170-176	mitogen-activated protein kinase 14	Homo sapiens	101-104
34939800-1	2022	We present the magnetic properties of a new family of S = 1 molecule-based magnets, NiF2(3,5-lut)4 2H2O and NiX2(3,5-lut)4, where X = HF2, Cl, Br, or I (lut = lutidine C7H9N).	Lutein	153-156	zinc finger protein 335	Homo sapiens	84-88
34766659-6	2022	Additionally, LUT suppressed caspase-3 activity, increased anti-inflammatory cytokine-IL-10 level, and reduced pathological lesions in the examined organs of rats cotreated with LUT and DOX.	Lutein	178-181	interleukin 10	Rattus norvegicus	86-91
34435724-11	2021	LU pretreatment also enhanced cardiac thioredoxin (Trx) and glutathione (GSH) contents as well as reduced lipid peroxidation, compared to the untreated group.	Lutein	0-2	thioredoxin 1	Rattus norvegicus	38-49
34435724-11	2021	LU pretreatment also enhanced cardiac thioredoxin (Trx) and glutathione (GSH) contents as well as reduced lipid peroxidation, compared to the untreated group.	Lutein	0-2	thioredoxin 1	Rattus norvegicus	51-54
34435724-14	2021	In conclusion, this study revealed that LU could ameliorate ISO-induced MI in rats by modulating MIAT/miR-200a/Nrf2 pathway.	Lutein	40-42	myocardial infarction associated transcript	Rattus norvegicus	97-101
34435724-14	2021	In conclusion, this study revealed that LU could ameliorate ISO-induced MI in rats by modulating MIAT/miR-200a/Nrf2 pathway.	Lutein	40-42	microRNA 200a	Rattus norvegicus	102-110
34435724-14	2021	In conclusion, this study revealed that LU could ameliorate ISO-induced MI in rats by modulating MIAT/miR-200a/Nrf2 pathway.	Lutein	40-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	111-115
34620441-0	2021	AgZDS, a gene encoding zeta-carotene desaturase, increases lutein and beta-carotene contents in transgenic Arabidopsis and celery.	Lutein	59-65	zeta-carotene desaturase	Arabidopsis thaliana	23-47
34502488-8	2021	Further, we investigated the expression of pro- and anti-apoptotic cell death markers such as Bax, Bcl-2, Caspase-3, and Cox-2, which was significantly reduced in Abeta1-42 + Lut-treated mice brains compared to the brains of the Abeta-injected group.	Lutein	175-178	BCL2-associated X protein	Mus musculus	94-97
34129176-2	2021	In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-kappaB) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways.	Lutein	38-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-221
34129176-2	2021	In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-kappaB) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways.	Lutein	38-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	223-227
34129176-2	2021	In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-kappaB) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways.	Lutein	38-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-161
34129176-2	2021	In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-kappaB) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways.	Lutein	38-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
34502488-8	2021	Further, we investigated the expression of pro- and anti-apoptotic cell death markers such as Bax, Bcl-2, Caspase-3, and Cox-2, which was significantly reduced in Abeta1-42 + Lut-treated mice brains compared to the brains of the Abeta-injected group.	Lutein	175-178	B cell leukemia/lymphoma 2	Mus musculus	99-104
34502488-8	2021	Further, we investigated the expression of pro- and anti-apoptotic cell death markers such as Bax, Bcl-2, Caspase-3, and Cox-2, which was significantly reduced in Abeta1-42 + Lut-treated mice brains compared to the brains of the Abeta-injected group.	Lutein	175-178	caspase 3	Mus musculus	106-115
34502488-8	2021	Further, we investigated the expression of pro- and anti-apoptotic cell death markers such as Bax, Bcl-2, Caspase-3, and Cox-2, which was significantly reduced in Abeta1-42 + Lut-treated mice brains compared to the brains of the Abeta-injected group.	Lutein	175-178	cytochrome c oxidase II, mitochondrial	Mus musculus	121-126
34502488-10	2021	We also checked the expression of synaptic markers such as PSD-95 and SNAP-25, which was significantly enhanced in Abeta1-42 + Lut-treated mice.	Lutein	127-130	discs large MAGUK scaffold protein 4	Mus musculus	59-65
34502488-10	2021	We also checked the expression of synaptic markers such as PSD-95 and SNAP-25, which was significantly enhanced in Abeta1-42 + Lut-treated mice.	Lutein	127-130	synaptosomal-associated protein 25	Mus musculus	70-77
34187949-10	2021	Therefore, we conclude that lutein protects against vancomycin-induced renal injury by potentially upregulating PPARgamma/Nrf2 expression in the renal tissues, and consequently downregulating the pathways: inflammation by NF-kappaB and apoptosis by caspase-3.	Lutein	28-34	peroxisome proliferator activated receptor gamma	Mus musculus	112-121
34187949-10	2021	Therefore, we conclude that lutein protects against vancomycin-induced renal injury by potentially upregulating PPARgamma/Nrf2 expression in the renal tissues, and consequently downregulating the pathways: inflammation by NF-kappaB and apoptosis by caspase-3.	Lutein	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
34187949-10	2021	Therefore, we conclude that lutein protects against vancomycin-induced renal injury by potentially upregulating PPARgamma/Nrf2 expression in the renal tissues, and consequently downregulating the pathways: inflammation by NF-kappaB and apoptosis by caspase-3.	Lutein	28-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	222-231
34187949-10	2021	Therefore, we conclude that lutein protects against vancomycin-induced renal injury by potentially upregulating PPARgamma/Nrf2 expression in the renal tissues, and consequently downregulating the pathways: inflammation by NF-kappaB and apoptosis by caspase-3.	Lutein	28-34	caspase 3	Mus musculus	249-258
34084220-4	2021	The results demonstrated that CASC9 was the most significantly downregulated lncRNA in MCF7 cells treated with lutein.	Lutein	111-117	cancer susceptibility 9	Homo sapiens	30-35
33946898-7	2021	In addition, the enzymatic antioxidants glutathione peroxidase (GPx) and catalase (CAT) and non-enzymatic antioxidant glutathione (GSH) were enhanced in cells treated with Lut and Lut-DG.	Lutein	172-175	catalase	Homo sapiens	73-81
35204141-0	2022	Serum Lutein and Zeaxanthin Are Inversely Associated with High-Sensitivity C-Reactive Protein in Non-Smokers: The Mikkabi Study.	Lutein	6-12	C-reactive protein	Homo sapiens	75-93
33946898-7	2021	In addition, the enzymatic antioxidants glutathione peroxidase (GPx) and catalase (CAT) and non-enzymatic antioxidant glutathione (GSH) were enhanced in cells treated with Lut and Lut-DG.	Lutein	172-175	catalase	Homo sapiens	83-86
33529717-7	2021	CONCLUSIONS: Overall, we suggest that the effects of lutein on attenuating excessive lipid accumulation are dependent on the SIRT1-mediated pathway in vivo and in vitro, which indicates that lutein administration may be a potential strategy for preventing excessive lipid accumulation and obesity.	Lutein	53-59	sirtuin 1	Mus musculus	125-130
33529717-7	2021	CONCLUSIONS: Overall, we suggest that the effects of lutein on attenuating excessive lipid accumulation are dependent on the SIRT1-mediated pathway in vivo and in vitro, which indicates that lutein administration may be a potential strategy for preventing excessive lipid accumulation and obesity.	Lutein	191-197	sirtuin 1	Mus musculus	125-130
33528746-3	2021	In this study, we overexpressed the LCYE gene in C. reinhardtii to estimate its effect on lycopene metabolism and lutein production.	Lutein	114-120	uncharacterized protein	Chlamydomonas reinhardtii	36-40
31441965-1	2019	The covalent nature of strong N-Br   N halogen bonds in a cocrystal (2) of N-bromosuccinimide (NBS) with 3,5-dimethylpyridine (lut) was determined from X-ray charge density studies and compared to a weak N-Br   O halogen bond in pure crystalline NBS (1) and a covalent bond in bis(3-methylpyridine)bromonium cation (in its perchlorate salt (3).	Lutein	127-130	nibrin	Homo sapiens	95-98
31770788-0	2020	[Effect of Dyes Containing Lutein on Enhanced Visibility of Epiretinal Pathologies in Intraoperative OCT].	Lutein	27-33	plexin A2	Homo sapiens	101-104
32995076-10	2020	Mature-green fruits also displayed a salt-dependent higher induction in the expression of PSY1, PDS, ZDS, and LYCB, key genes of the carotenoid biosynthesis pathway, in correlation with increased lycopene, lutein, beta-carotene, and violaxanthin levels.	Lutein	206-212	phytoene synthase 1, chloroplastic	Solanum lycopersicum	90-94
32665315-14	2020	Increased vascular leakage and decreased occludin expression were observed in the Ins2Akita/+ mouse retina, and these alterations were attenuated by lutein treatment.	Lutein	149-155	occludin	Mus musculus	41-49
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	C-C motif chemokine ligand 2	Homo sapiens	146-151
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	colony stimulating factor 1	Homo sapiens	153-158
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	C-X-C motif chemokine ligand 10	Homo sapiens	164-171
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	tumor necrosis factor	Homo sapiens	199-208
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lutein	67-73	C-X-C motif chemokine ligand 10	Homo sapiens	228-235
32410856-7	2020	beta-Cryptoxanthin, lutein, and lycopene dramatically downregulated the fructose-induced CXCL-10 expression in vascular cells.	Lutein	20-26	C-X-C motif chemokine ligand 10	Homo sapiens	89-96
31659623-7	2020	In contrast, the replacement of violaxanthin by lutein in CP24 is not significantly increasing [Formula: see text].	Lutein	48-54	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	58-62
31820335-0	2020	Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE-19) cells.	Lutein	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
31820335-12	2020	Further, lutein protected high glucose-mediated down-regulation of a redox-sensitive transcription factor, Nrf2, and antioxidant enzymes, SOD2, HO-1, and catalase.	Lutein	9-15	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
31820335-12	2020	Further, lutein protected high glucose-mediated down-regulation of a redox-sensitive transcription factor, Nrf2, and antioxidant enzymes, SOD2, HO-1, and catalase.	Lutein	9-15	superoxide dismutase 2	Homo sapiens	138-142
31820335-12	2020	Further, lutein protected high glucose-mediated down-regulation of a redox-sensitive transcription factor, Nrf2, and antioxidant enzymes, SOD2, HO-1, and catalase.	Lutein	9-15	heme oxygenase 1	Homo sapiens	144-162
31820335-13	2020	This protective effect of lutein was linked with activated nuclear translocation of Nrf2, which was associated with increased activation of regulatory proteins such as Erk and AKT.	Lutein	26-32	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
31820335-13	2020	This protective effect of lutein was linked with activated nuclear translocation of Nrf2, which was associated with increased activation of regulatory proteins such as Erk and AKT.	Lutein	26-32	mitogen-activated protein kinase 1	Homo sapiens	168-171
31820335-13	2020	This protective effect of lutein was linked with activated nuclear translocation of Nrf2, which was associated with increased activation of regulatory proteins such as Erk and AKT.	Lutein	26-32	AKT serine/threonine kinase 1	Homo sapiens	176-179
31982478-0	2020	ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.	Lutein	95-101	activin A receptor type 1B	Homo sapiens	0-4
31982478-0	2020	ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.	Lutein	95-101	SMAD family member 3	Homo sapiens	5-10
31982478-0	2020	ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.	Lutein	95-101	serpin family E member 1	Homo sapiens	70-75
31982478-3	2020	At present, it is not known whether activin A can regulate the expression and production of PAI in human granulosa lutein (hGL) cells.	Lutein	115-121	lipase F, gastric type	Homo sapiens	123-126
31936902-5	2020	The aim of this study was to investigate the effect of TGF-beta1 on the production of GDNF and its underlying mechanisms in human granulosa-lutein (hGL) cells.	Lutein	140-146	transforming growth factor beta 1	Homo sapiens	55-64
31936902-5	2020	The aim of this study was to investigate the effect of TGF-beta1 on the production of GDNF and its underlying mechanisms in human granulosa-lutein (hGL) cells.	Lutein	140-146	glial cell derived neurotrophic factor	Homo sapiens	86-90
31936902-5	2020	The aim of this study was to investigate the effect of TGF-beta1 on the production of GDNF and its underlying mechanisms in human granulosa-lutein (hGL) cells.	Lutein	140-146	lipase F, gastric type	Homo sapiens	148-151
31745176-8	2019	Serum levels of the xanthophyll carotenoid lutein were positively associated with eGFR in analyses adjusted for age (years), gender, smoking, APOE4 status and Alzheimer"s disease.	Lutein	43-49	apolipoprotein E	Homo sapiens	142-147
31542898-0	2019	Effect of lutein on the acute inflammation-induced c-Fos expression of rat trigeminal spinal nucleus caudalis and C1 dorsal horn neurons.	Lutein	10-16	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
31542898-2	2019	The aim of the present study was to investigate whether pretreatment with lutein attenuates acute inflammation-induced sensitization of nociceptive processing in rat spinal trigeminal nucleus caudalis (SpVc) and upper cervical (C1) dorsal horn neurons, via c-Fos immunoreactivity.	Lutein	74-80	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	257-262
31441965-1	2019	The covalent nature of strong N-Br   N halogen bonds in a cocrystal (2) of N-bromosuccinimide (NBS) with 3,5-dimethylpyridine (lut) was determined from X-ray charge density studies and compared to a weak N-Br   O halogen bond in pure crystalline NBS (1) and a covalent bond in bis(3-methylpyridine)bromonium cation (in its perchlorate salt (3).	Lutein	127-130	nibrin	Homo sapiens	246-249
31026089-2	2019	In the current study, a plausible interaction of L and OXL with AMPK was investigated by molecular docking.	Lutein	49-50	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	64-68
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	59-63
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	PPARG coactivator 1 alpha	Homo sapiens	103-170
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	PPARG coactivator 1 alpha	Homo sapiens	172-182
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	transcription factor A, mitochondrial	Homo sapiens	185-189
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	superoxide dismutase 2	Homo sapiens	258-280
31026089-3	2019	In addition, the effect of L and OXL for the activation of AMPK that triggers the downstream regulator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), TFAM expression, mitochondrial DNA (mtDNA), mitochondrial biogenesis and superoxide dismutase 2 (SOD2) in high glucose treated HepG2 cells were investigated by quantitative polymerase chain reaction and Western blot analysis.	Lutein	27-28	superoxide dismutase 2	Homo sapiens	282-286
31026089-5	2019	The phosphorylation of AMPK increased by 1.3- and 1.5-fold with L and OXL treatment, respectively, in high glucose induced HepG2 cells.	Lutein	64-65	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	23-27
30772442-0	2019	Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of acetylcholinesterase activity.	Lutein	23-29	acetylcholinesterase	Rattus norvegicus	98-118
30833603-8	2019	In conclusion, colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism.	Lutein	91-97	dicer 1, ribonuclease III	Homo sapiens	124-130
23431043-3	2013	Carotenoids, including lutein and lycopene, enhanced MMP-9 activity in RAW264.7 macrophages.	Lutein	23-29	matrix metallopeptidase 9	Mus musculus	53-58
31140624-7	2019	Among five carotenoids tested, ASTX and LT attenuated HSC activation in LX-2 cells by reducing the mRNA and protein levels of pro-fibrogenic genes, such as smooth muscle alpha actin and procollagen type I alpha1 (COL1A1).	Lutein	40-42	collagen type I alpha 1 chain	Homo sapiens	213-219
30772442-9	2019	Oral administration of lutein (50 mg/kg during 14 days) attenuated memory deficit and the increase of acetylcholinesterase activity induced by ethanol.	Lutein	23-29	acetylcholinesterase	Rattus norvegicus	102-122
30083786-4	2018	Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway.	Lutein	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	137-180
30083786-4	2018	Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway.	Lutein	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
21670343-6	2011	Significant synergy indices supported the possibility of biological interaction between CFH Y402H and zinc, beta-carotene, lutein/zeaxanthin, and eicosapentaenoic/docosahexaenoic acid (EPA/DHA) and between LOC387715 A69S and zinc and EPA/DHA (all P < .05).	Lutein	123-129	complement factor H	Homo sapiens	88-91