PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11255638-1	2001	The zinc(II)-binding affinities of recombinant human growth hormone and two its mutants, 14-33 and 14-95, were studied using Immobilized Metal Ion Affinity Gel-electrophoresis (IMAG).	Zinc	4-12	growth hormone 1	Homo sapiens	53-67
16233148-7	2001	The optimum temperature for MBP-fused GnT-I activity was 40 degrees C, but the enzyme was active between 0-70 degrees C. Mn2+ and Co2+ were critical for the enzyme activity, while Zn2+ and Ca2+ inhibited the activity.	Zinc	180-184	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	38-43
11106490-9	2000	The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory.	Zinc	119-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
11163276-3	2000	In NMDA receptors, the high-affinity Zn inhibition is eliminated by mutations in the LIVBP-like domain of the NR2A subunit.	Zinc	37-39	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	110-114
11185553-3	2000	Interestingly, the binding of rHRG to the ligand required the divalent transition-metal ions such as Zn2+, Ni2+, and Co2+ at pH 9.5.	Zinc	101-105	histidine-rich glycoprotein	Rattus norvegicus	30-34
10913138-8	2000	Furthermore, co-immunoprecipitation experiments demonstrated that Ca(2+)/Zn(2+) stabilizes S100B-S100A6 and S100B-S100A11 heterocomplexes.	Zinc	73-79	S100 calcium binding protein B	Homo sapiens	91-96
10913138-8	2000	Furthermore, co-immunoprecipitation experiments demonstrated that Ca(2+)/Zn(2+) stabilizes S100B-S100A6 and S100B-S100A11 heterocomplexes.	Zinc	73-79	S100 calcium binding protein A6	Homo sapiens	97-103
10913138-8	2000	Furthermore, co-immunoprecipitation experiments demonstrated that Ca(2+)/Zn(2+) stabilizes S100B-S100A6 and S100B-S100A11 heterocomplexes.	Zinc	73-79	S100 calcium binding protein B	Homo sapiens	108-113
10913138-8	2000	Furthermore, co-immunoprecipitation experiments demonstrated that Ca(2+)/Zn(2+) stabilizes S100B-S100A6 and S100B-S100A11 heterocomplexes.	Zinc	73-79	S100 calcium binding protein A11	Homo sapiens	114-121
11062174-8	2000	Simultaneous treatment with Zn(II) prevented largely the inhibition induced by Cd(II), Co(II), and Ni(II), but only slightly in the case of Cu(II).	Zinc	28-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
11040433-4	2000	The phenotypes of the flp mutant strains suggest that FlpA and FlpB control the expression of high and low affinity ATP-dependent Zn(II) uptake systems, respectively.	Zinc	130-136	flp	Lactococcus lactis	22-25
18968115-18	2000	As for Zn, the highest percentage was found in the fraction corresponding to alpha-lactalbumin.	Zinc	7-9	lactalbumin alpha	Homo sapiens	77-94
11027581-0	2000	A pivotal role of Zn-binding residues in the function of the copper chaperone for SOD1.	Zinc	18-20	superoxide dismutase 1	Homo sapiens	82-86
11009601-9	2000	Addition of two Zn(2+)/hexamer and phenol results in the displacement of the myristoyl moiety from the dimer interface and formation of stable R(6) hexamers similar to those formed by human insulin.	Zinc	16-18	insulin	Homo sapiens	190-197
11051099-3	2000	Among various metal ions examined, Fe3+, Cu2+, Zn2+, and Cd2+ exerted their inactivational effects on VHR, and Cu2+ is the most potent inactivator.	Zinc	47-51	dual specificity phosphatase 3	Homo sapiens	102-105
11051099-11	2000	Thus, we conclude that the highly potent Cu2+ inactivation of VHR is a consequence of the oxidation of the active-site cysteine and the mode of Zn2+ inactivation is distinct from that of Cu2+.	Zinc	144-148	dual specificity phosphatase 3	Homo sapiens	62-65
11041561-8	2000	ClC-2 channels are also blocked by Zn2+ and Cd2+.	Zinc	35-39	chloride voltage-gated channel 2	Rattus norvegicus	0-5
10986126-9	2000	Additionally, MMP-1 and MMP-13 exhibit different dynamic properties for the active-site loop and the structural Zn-binding region.	Zinc	112-114	matrix metallopeptidase 13	Homo sapiens	24-30
10947965-2	2000	Similarly, chemical modification of the thiol residues present in both reduced and Zn(2+)-depleted trimer converts TRAIL into an inactive dimer.	Zinc	83-89	TNF superfamily member 10	Homo sapiens	115-120
10995207-1	2000	Zn(2+) and Co(2+) ions are known to promote human growth hormone reversible dimerization.	Zinc	0-6	growth hormone 1	Homo sapiens	50-64
10842171-2	2000	Purified calreticulin was digested with trypsin in the presence or absence of Ca(2+), Zn(2+), and ATP.	Zinc	86-92	calreticulin	Homo sapiens	9-21
10842171-7	2000	Trypsin digestion of calreticulin in the presence of Zn(2+) resulted in the formation of a 17-kDa central protease-resistant core in the protein corresponding to the central region of the protein, indicating that under these conditions the N- and C-domains of the protein are in an extended conformation.	Zinc	53-55	calreticulin	Homo sapiens	21-33
11128869-1	2000	Enzyme activities of acid sphingomyelinase (ASM) were determined in various human cell-free body fluids, serum, cerebrospinal fluid, urine, salivary fluid, tear fluid, and synovial fluid, using assay buffers with or without Zn2+ -cation.	Zinc	224-228	sphingomyelin phosphodiesterase 1	Homo sapiens	21-42
11128869-1	2000	Enzyme activities of acid sphingomyelinase (ASM) were determined in various human cell-free body fluids, serum, cerebrospinal fluid, urine, salivary fluid, tear fluid, and synovial fluid, using assay buffers with or without Zn2+ -cation.	Zinc	224-228	sphingomyelin phosphodiesterase 1	Homo sapiens	44-47
11128869-3	2000	All ASMs detected in the fluids were stimulated by the addition of Zn2+ -cation, suggesting that those enzymes are secretory ASM derived from ASM gene.	Zinc	67-71	sphingomyelin phosphodiesterase 1	Homo sapiens	4-7
11128869-3	2000	All ASMs detected in the fluids were stimulated by the addition of Zn2+ -cation, suggesting that those enzymes are secretory ASM derived from ASM gene.	Zinc	67-71	sphingomyelin phosphodiesterase 1	Homo sapiens	125-128
10920035-2	2000	Hexamers of insulin containing predominantly two, but up to four, Zn(2+) ions were observed in the gas phase when solutions at pH 4.0 were examined.	Zinc	66-68	insulin	Homo sapiens	12-19
10916081-5	2000	RESULTS: The expression of prepro-ET-1 mRNA and ET-1 was markedly greater in the OK than in the CLK in the standard and the Zn-deficient diet groups.	Zinc	124-126	endothelin 1	Rattus norvegicus	34-38
10916081-5	2000	RESULTS: The expression of prepro-ET-1 mRNA and ET-1 was markedly greater in the OK than in the CLK in the standard and the Zn-deficient diet groups.	Zinc	124-126	endothelin 1	Rattus norvegicus	48-52
10916081-6	2000	However, the expression of prepro-ET-1 mRNA and ET-1 was substantially increased in the OK of the Zn-deficient diet group relative to the OK of the standard diet group.	Zinc	98-100	endothelin 1	Rattus norvegicus	34-38
10916081-6	2000	However, the expression of prepro-ET-1 mRNA and ET-1 was substantially increased in the OK of the Zn-deficient diet group relative to the OK of the standard diet group.	Zinc	98-100	endothelin 1	Rattus norvegicus	48-52
10916081-8	2000	Administration of enalapril restored the expression of prepro-ET-1 mRNA and ET-1 in the OK to levels seen in the CLK in the standard and the Zn-deficient diet groups.	Zinc	141-143	endothelin 1	Rattus norvegicus	62-66
11121108-1	2001	Insulin-regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn(2+)-coordination sequence element, HEXXH-(18-64X)-E. A second conserved sequence element, the GXMEN motif, positioned 22-32 amino acids N-terminal to the Zn(2+)-coordination sequence element distinguishes the gluzincin aminopeptidases from other gluzincins.	Zinc	167-169	leucyl and cystinyl aminopeptidase	Homo sapiens	0-32
11121108-1	2001	Insulin-regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn(2+)-coordination sequence element, HEXXH-(18-64X)-E. A second conserved sequence element, the GXMEN motif, positioned 22-32 amino acids N-terminal to the Zn(2+)-coordination sequence element distinguishes the gluzincin aminopeptidases from other gluzincins.	Zinc	167-169	leucyl and cystinyl aminopeptidase	Homo sapiens	34-38
11121108-1	2001	Insulin-regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn(2+)-coordination sequence element, HEXXH-(18-64X)-E. A second conserved sequence element, the GXMEN motif, positioned 22-32 amino acids N-terminal to the Zn(2+)-coordination sequence element distinguishes the gluzincin aminopeptidases from other gluzincins.	Zinc	324-326	leucyl and cystinyl aminopeptidase	Homo sapiens	0-32
11121108-1	2001	Insulin-regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn(2+)-coordination sequence element, HEXXH-(18-64X)-E. A second conserved sequence element, the GXMEN motif, positioned 22-32 amino acids N-terminal to the Zn(2+)-coordination sequence element distinguishes the gluzincin aminopeptidases from other gluzincins.	Zinc	324-326	leucyl and cystinyl aminopeptidase	Homo sapiens	34-38
11121108-5	2001	The results show that conservation of residues within the GAMEN and Zn(2+)-binding motifs is important for IRAP enzyme activity.	Zinc	68-74	leucyl and cystinyl aminopeptidase	Homo sapiens	107-111
10984504-2	2000	Recombinant NR1/NR2A receptors exhibit a much higher apparent affinity for voltage-independent Zn(2+) inhibition than receptors with other subunit combinations.	Zinc	95-97	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	12-15
10984504-2	2000	Recombinant NR1/NR2A receptors exhibit a much higher apparent affinity for voltage-independent Zn(2+) inhibition than receptors with other subunit combinations.	Zinc	95-97	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	16-20
10984504-3	2000	Here, we show that the mechanism of this apparent high-affinity, voltage-independent Zn(2+) inhibition for NR2A-containing receptors results from the enhancement of proton inhibition.	Zinc	85-87	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	107-111
10984504-4	2000	We also show that the N-terminal leucine/isoleucine/valine binding protein (LIVBP)-like domain of the NR2A subunit contains critical determinants of the apparent high-affinity, voltage-independent Zn(2+) inhibition.	Zinc	197-199	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	102-106
10856290-5	2000	X-ray fluorescence spectra revealed that RPA70-CTD possesses a coordinated Zn(II).	Zinc	75-81	CTD	Homo sapiens	47-50
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	27-29	CTD	Homo sapiens	92-95
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	166-168	CTD	Homo sapiens	92-95
10985916-5	2000	The low Zn levels result in deficient CuZnSuperoxide dismutase (CuZnSOD), which in turn leads to increased levels of superoxide.	Zinc	8-10	superoxide dismutase 1	Homo sapiens	38-62
10985916-5	2000	The low Zn levels result in deficient CuZnSuperoxide dismutase (CuZnSOD), which in turn leads to increased levels of superoxide.	Zinc	8-10	superoxide dismutase 1	Homo sapiens	64-71
10962094-6	2000	On the other hand, Zn(2+), spermine, and spermidine, each a major component of seminal and prostatic fluid, strongly inhibit rPSA activity, with Zn(2+) being a non-competitive inhibitor while spermine is a competitive inhibitor.	Zinc	19-21	aminopeptidase puromycin sensitive	Rattus norvegicus	125-129
10962094-6	2000	On the other hand, Zn(2+), spermine, and spermidine, each a major component of seminal and prostatic fluid, strongly inhibit rPSA activity, with Zn(2+) being a non-competitive inhibitor while spermine is a competitive inhibitor.	Zinc	19-22	aminopeptidase puromycin sensitive	Rattus norvegicus	125-129
10962094-7	2000	Citrate, also a major component of seminal and prostatic fluid, spermine, and spermidine each protect rPSA from Zn(2+) inhibition, presumably via Zn(2+) sequestration.	Zinc	112-114	aminopeptidase puromycin sensitive	Rattus norvegicus	102-106
10962094-7	2000	Citrate, also a major component of seminal and prostatic fluid, spermine, and spermidine each protect rPSA from Zn(2+) inhibition, presumably via Zn(2+) sequestration.	Zinc	146-148	aminopeptidase puromycin sensitive	Rattus norvegicus	102-106
10859323-9	2000	An alteration in the steroid-binding specificity of human SHBG by Zn(2+) occupancy of site II may be relevant in male reproductive tissues where zinc concentrations are very high.	Zinc	66-68	sex hormone binding globulin	Homo sapiens	58-62
10975256-3	2000	Lys14p nuclear localisation is mediated by a tripartite sequence made up of three short basic motifs located on the C-terminal side of the Zn cluster domain of Lys14p.	Zinc	139-141	Lys14p	Saccharomyces cerevisiae S288C	0-6
10975256-3	2000	Lys14p nuclear localisation is mediated by a tripartite sequence made up of three short basic motifs located on the C-terminal side of the Zn cluster domain of Lys14p.	Zinc	139-141	Lys14p	Saccharomyces cerevisiae S288C	160-166
10801774-1	2000	Abeta binds Zn(2+), Cu(2+), and Fe(3+) in vitro, and these metals are markedly elevated in the neocortex and especially enriched in amyloid plaque deposits of individuals with Alzheimer"s disease (AD).	Zinc	12-14	amyloid beta precursor protein	Homo sapiens	0-5
10801774-2	2000	Zn(2+) precipitates Abeta in vitro, and Cu(2+) interaction with Abeta promotes its neurotoxicity, correlating with metal reduction and the cell-free generation of H(2)O(2) (Abeta1-42 > Abeta1-40 > ratAbeta1-40).	Zinc	0-2	amyloid beta precursor protein	Homo sapiens	20-25
10858283-5	2000	Similarly to DNase I, the nuclease activity of DNase X was dependent on Ca(2+) and Mg(2+) and inhibited by Zn(2+) ions or chelators of bivalent cations.	Zinc	107-109	deoxyribonuclease 1 like 1	Homo sapiens	47-54
10834943-8	2000	In the presence of ultra-low [O(2)(*-)](steady state), the oxidized form of SOD [Cu(II),Zn-SOD] or SOD mimic (oxo-ammonium cation) does not react with O(2)(*-) but rather oxidizes the target molecule that it was supposed to have protected.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	76-79
10783316-11	2000	Addition of Fe or Zn to the culture medium during TRX treatment led to a complete restoration of proliferation rate and inhibition of apoptosis, demonstrating that Fe/Zn-saturated TRX was not toxic in the absence of metal depletion.	Zinc	18-20	VAC14 component of PIKFYVE complex	Homo sapiens	50-53
10783316-11	2000	Addition of Fe or Zn to the culture medium during TRX treatment led to a complete restoration of proliferation rate and inhibition of apoptosis, demonstrating that Fe/Zn-saturated TRX was not toxic in the absence of metal depletion.	Zinc	18-20	VAC14 component of PIKFYVE complex	Homo sapiens	180-183
10801964-7	2000	In addition, Abeta produces hydrogen peroxide in a Cu(II)/Fe(III)-dependent manner, and the hydrogen peroxide formation is quenched by Zn(II).	Zinc	135-137	amyloid beta precursor protein	Homo sapiens	13-18
10769136-0	2000	A novel approach to serine protease inhibition: kinetic characterization of inhibitors whose potencies and selectivities are dramatically enhanced by Zinc(II).	Zinc	150-158	coagulation factor II, thrombin	Homo sapiens	20-35
10769136-2	2000	We report the kinetic characterization of a class of serine protease inhibitors whose potencies and selectivities are dramatically enhanced in the presence of Zn(II).	Zinc	159-165	coagulation factor II, thrombin	Homo sapiens	53-68
10725096-4	2000	In the concentration range studied, all four of the conjugates and Zn-free insulin exist as stable dimers while Zn(2+)-insulin was exclusively hexameric and Lispro was monomeric.	Zinc	67-69	insulin	Homo sapiens	75-82
10774735-0	2000	Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.	Zinc	95-99	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	60-64
10774735-2	2000	The apparent affinity for Zn2+ of the heteromeric NMDA receptors is determined by the subtype of NR2 subunit expressed, with NR2A-containing receptors being the most sensitive (IC50, approximately 20 nM) and NR2C-containing receptors being the least sensitive (IC50, approximately 30 microM).	Zinc	26-30	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	125-129
10774735-3	2000	Using chimeras constructed from these two NR2 subtypes, we show that the N-terminal LIVBP-like domain of the NR2A subunit controls the high-affinity Zn2+ inhibition.	Zinc	149-153	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	109-113
10642521-1	2000	Leukotriene A(4) hydrolase is a bifunctional Zn(2+)-containing enzyme catalysing the formation of the potent chemotaxin leukotriene B(4).	Zinc	45-51	leukotriene A4 hydrolase	Homo sapiens	0-26
12483584-3	2000	In comparison with the TAA-Cwp1 expressing strain, these cells exhibited 1.6- to 2.8-fold higher adsorbing capacity for Cu(2+), Ni(2+), and Zn(2+).	Zinc	140-142	Cwp1p	Saccharomyces cerevisiae S288C	27-31
10888278-8	2000	Human THP-1 monocytes were exposed for 24 h to sublethal concentrations of ions of Ag, Be, Co, Cu, Hg, Ni, Pd, and Zn--all known to be released from dental biomaterials.	Zinc	115-117	GLI family zinc finger 2	Homo sapiens	6-11
10793233-1	2000	Mice over-expressing a human mutation of Cu(2+)/Zn(2+) superoxide dismutase (SOD1) provide a model of amyotrophic lateral sclerosis.	Zinc	48-50	superoxide dismutase 1	Homo sapiens	77-81
10788426-2	2000	In addition to Ca(2+), several members of the S100 protein family, including S100A2, bind Zn(2+).	Zinc	90-92	S100 calcium binding protein A1	Homo sapiens	46-50
10788426-3	2000	Two regions in the amino acid sequences of S100 proteins, namely the helices of the N-terminal EF-hand motif and the very C-terminal loop are believed to be involved in Zn(2+)-binding due to the presence of histidine and/or cysteine residues.	Zinc	169-175	S100 calcium binding protein A1	Homo sapiens	43-47
10783332-4	2000	It has been suggested that the carcinogenic properties of cadmium may result from structural changes effected in XPA when Cd(2+) is substituted for Zn(2+) in the metal-binding site.	Zinc	148-154	XPA, DNA damage recognition and repair factor	Homo sapiens	113-116
10832070-5	2000	The activity of the antioxidant enzymes CuZn (CuZnSOD) and Mn (MnSOD) superoxide dismutases was significantly higher in the 0.5 and 5 microM Zn cells compared to the 50 microM Zn and control groups at both the 24 and 48 h time points.	Zinc	42-44	superoxide dismutase 1, soluble	Mus musculus	46-53
10832070-5	2000	The activity of the antioxidant enzymes CuZn (CuZnSOD) and Mn (MnSOD) superoxide dismutases was significantly higher in the 0.5 and 5 microM Zn cells compared to the 50 microM Zn and control groups at both the 24 and 48 h time points.	Zinc	48-50	superoxide dismutase 1, soluble	Mus musculus	40-44
10995024-1	2000	Investigation of the protein product of the oestrogen-regulated gene LIV-1, implicated in metastatic breast cancer, has revealed 10 protein sequences of unknown function that belong to a new family with potential to control intracellular Zn2+ homeostasis.	Zinc	238-242	solute carrier family 39 member 6	Homo sapiens	69-74
10762665-6	2000	These unique effects of dithiocarbamates on NF-kappaB were tightly linked to their ability to elevate intracellular Zn(2+)500 microM), dithiocarbamates started to lose their ability to promote Zn(2+) influx and to inhibit NF-kappaB activation.	Zinc	116-118	nuclear factor kappa B subunit 1	Homo sapiens	44-53
10762665-6	2000	These unique effects of dithiocarbamates on NF-kappaB were tightly linked to their ability to elevate intracellular Zn(2+)500 microM), dithiocarbamates started to lose their ability to promote Zn(2+) influx and to inhibit NF-kappaB activation.	Zinc	116-122	nuclear factor kappa B subunit 1	Homo sapiens	44-53
11543272-6	2000	The enzyme operates with multiple turnover in the presence of micromolar concentrations of Zn2+, exhibiting saturation kinetics and a catalytic rate of >1 min-1.	Zinc	91-95	CD59 molecule (CD59 blood group)	Homo sapiens	158-163
10725096-4	2000	In the concentration range studied, all four of the conjugates and Zn-free insulin exist as stable dimers while Zn(2+)-insulin was exclusively hexameric and Lispro was monomeric.	Zinc	112-114	insulin	Homo sapiens	119-126
10725096-6	2000	This independent method qualitatively suggests that mPEG-insulin conjugates behave similarly to Zn-free insulin in the concentration range studied and complements results from ultracentrifugation studies.	Zinc	96-98	insulin	Homo sapiens	104-111
10701254-2	2000	When cells were incubated in buffer containing Zinquin, application of insulin secretagogues evoked an increase in fluorescence around the surface of the cell, indicative of detection of Zn2+ efflux from the cell.	Zinc	187-191	insulin	Homo sapiens	71-78
10701254-7	2000	Since insulin is co-stored with Zn2+ in secretory vesicles, it was concluded that the Zn2+ efflux corresponded to exocytosis of insulin/Zn(2+)-containing granules from the beta-cell.	Zinc	86-90	insulin	Homo sapiens	6-13
10701254-7	2000	Since insulin is co-stored with Zn2+ in secretory vesicles, it was concluded that the Zn2+ efflux corresponded to exocytosis of insulin/Zn(2+)-containing granules from the beta-cell.	Zinc	86-90	insulin	Homo sapiens	128-135
10834943-8	2000	In the presence of ultra-low [O(2)(*-)](steady state), the oxidized form of SOD [Cu(II),Zn-SOD] or SOD mimic (oxo-ammonium cation) does not react with O(2)(*-) but rather oxidizes the target molecule that it was supposed to have protected.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	91-94
10834943-8	2000	In the presence of ultra-low [O(2)(*-)](steady state), the oxidized form of SOD [Cu(II),Zn-SOD] or SOD mimic (oxo-ammonium cation) does not react with O(2)(*-) but rather oxidizes the target molecule that it was supposed to have protected.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	91-94
10620505-1	2000	With the use of a [(3)H]ryanodine binding assay, the modulation of skeletal muscle ryanodine receptor (RyR1) by Zn(2+) was investigated.	Zinc	112-114	ryanodine receptor 1	Homo sapiens	67-101
11272543-5	2000	[1]3+ was converted to an aza-capped Co4(III)Zn4(II) octanuclear complex, [Zn4O[Co(L)]4]6+ ([2]6+), by reaction with I- in the presence of Zn2+ and ZnO in water.	Zinc	139-143	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	41-44
11272543-9	2000	Treatment of [2]6+ with a basic aqueous solution resulted in a cleavage of the Zn-S bonds to produce an aza-capped Co(III) mononuclear complex, [Co(L)] ([3]), from which [1]3+ is readily reproduced by the reaction with Ag+ in water.	Zinc	79-81	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	115-122
10620505-1	2000	With the use of a [(3)H]ryanodine binding assay, the modulation of skeletal muscle ryanodine receptor (RyR1) by Zn(2+) was investigated.	Zinc	112-114	ryanodine receptor 1	Homo sapiens	103-107
10620505-11	2000	Moreover, some interactions were found in the effects between Zn(2+) and other RyR1 modulators.	Zinc	62-64	ryanodine receptor 1	Homo sapiens	79-83
10620505-12	2000	It is indicated that Zn(2+) can modulate the activation sites and inactivation sites for Ca(2+) on RyR1.	Zinc	21-27	ryanodine receptor 1	Homo sapiens	99-103
10816735-1	1999	Previous in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner.	Zinc	50-54	prolactin	Homo sapiens	148-157
10675024-8	2000	These experiments demonstrated an acid-induced denaturation of BSA in the pH 3-4 range, and heat-induced unfolding of cytochrome c between 50 and 60 degrees C. Finally, Zn2+ binding was demonstrated for the carbonic anhydrase apoprotein.	Zinc	169-173	cytochrome c, somatic	Homo sapiens	118-130
11493757-2	2000	The rosette inhibition assay by Dardenne and Bach (1975) is the only method available to evaluate the biologically active form of this hormone (thymulin or Zn-facteur thymique serique, Zn-FTS), as immunoassays cannot discriminate between thymulin and the inactive form of the hormone not containing Zn (FTS).	Zinc	185-187	AKT interacting protein	Homo sapiens	188-191
11216508-2	2000	Male SD rats, 4 weeks old, were divided into four groups, and fed zinc-deficient (Zn-Def), low-zinc (Low-Zn), and zinc-sufficient diets with free access (Zn-Suf) and pair-feeding (Pair-fed).	Zinc	82-84	UTP25 small subunit processome component	Rattus norvegicus	85-88
22607412-3	2000	This subunit, which regulates transcriptional start-site selection and downstream pausing, contains Zn(2+)-binding motifs similar to those of general transcription factors TFIIB and TFIIS.	Zinc	100-106	general transcription factor IIB	Homo sapiens	172-177
22607412-3	2000	This subunit, which regulates transcriptional start-site selection and downstream pausing, contains Zn(2+)-binding motifs similar to those of general transcription factors TFIIB and TFIIS.	Zinc	100-106	transcription elongation factor A2	Homo sapiens	182-187
22607421-7	2000	Compared to the intrinsic zinc strongly bound to Cys 176, Cys 238, Cys 242 and His 179 in the p53 core domain, binding of additional Zn(2+) to p53 was much weaker as shown by an easy removal of the latter ions by low concentrations of EDTA.	Zinc	133-135	tumor protein p53	Homo sapiens	143-146
11006580-3	2000	H3 and H5 formed high affinity complexes with Cu(2+) and Ni(2+) and, to a lesser extent, with Zn(2+).	Zinc	94-96	histatin 3	Homo sapiens	0-2
11006580-3	2000	H3 and H5 formed high affinity complexes with Cu(2+) and Ni(2+) and, to a lesser extent, with Zn(2+).	Zinc	94-96	histatin 3	Homo sapiens	7-9
10567243-5	1999	S100A1 bound to immobilized synapsin IIa in BIAcore experiments in a Ca(2+)-dependent and Zn(2+)-enhanced manner with submicromolar affinity; this interaction could be competed for with synthetic peptides of the proposed S100A1-binding sites of synapsin.	Zinc	90-96	S100 calcium binding protein A1	Homo sapiens	0-6
10816735-1	1999	Previous in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner.	Zinc	50-54	prolactin	Homo sapiens	159-162
10816735-2	1999	Thus, Zn++ may regulate physiologically pituitary PRL secretion.	Zinc	6-10	prolactin	Homo sapiens	50-53
10816735-4	1999	In normal individuals Zn++ administration produced controversial results on PRL secretion.	Zinc	22-26	prolactin	Homo sapiens	76-79
10403771-3	1999	CML-rich poly-L-lysine and bovine serum albumin (BSA) were chemically prepared and found to bind non-dialyzable Cu(2+), Zn(2+) and Ca(2+).	Zinc	120-122	albumin	Homo sapiens	34-47
10701476-3	1999	In serum, Zn is closely bound to Alb.	Zinc	10-12	albumin	Homo sapiens	33-36
10701476-7	1999	In healthy volunteers and major depressed patients, there were significant and positive correlations between serum Zn and Alb.	Zinc	115-117	albumin	Homo sapiens	122-125
10701476-8	1999	We found that 53.8% of the variance in serum Zn could be explained by the combined effects of serum Alb and diagnostic classification.	Zinc	45-47	albumin	Homo sapiens	100-103
10701476-9	1999	The results suggest that lower serum Zn in depression is in part explained by lowered serum Alb and by another depression-related mechanism.	Zinc	37-39	albumin	Homo sapiens	92-95
10701476-10	1999	It is suggested that lower serum Zn in depression may be secondary to sequestration of metallothionein in the liver, which may be related to increased production of interleukin-6.	Zinc	33-35	interleukin 6	Homo sapiens	165-178
10630893-1	1999	Cu2+, Ni2+, Zn2+, Co2+ and Cd2+ were evaluated in metal ion affinity chromatography for enrichment of selenoprotein P, and immobilized Co2+ affinity chromatography was found to be the most selective chromatographic method.	Zinc	12-16	selenoprotein P	Homo sapiens	102-117
10564779-9	1999	These results suggest that carnosine and related compounds can protect the hydrogen peroxide-mediated Cu,Zn-SOD fragmentation through the scavenging of *OH.	Zinc	105-107	superoxide dismutase 1	Homo sapiens	108-111
10697511-6	1999	Treatment of U937 cells with GGO resulted in the release of cytochrome c from mitochondria prior to DNA fragmentation and the release of cytochrome c was inhibited by Zn2+ ions and by a chelator of Ca2+ ions but not by inhibitors of caspases such as Z-Asp-CH2DCB or Z-VAD-FMK.	Zinc	167-171	cytochrome c, somatic	Homo sapiens	137-149
10697511-7	1999	These results suggest that intracellular free Ca2+ ions, and some caspases that are inhibited by Zn2+ ions, but not by Z-Asp-CH2DCB or Z-VAD-FMK are necessary for the release of cytochrome c that is caused by the treatment with GGO.	Zinc	97-101	cytochrome c, somatic	Homo sapiens	178-190
10531471-2	1999	With recombinant receptors composed of NR1-1a/NR2A or NR1-1a/2B subunits, Src reduces voltage-independent inhibition by the divalent cation Zn2+.	Zinc	140-144	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	39-42
10531471-2	1999	With recombinant receptors composed of NR1-1a/NR2A or NR1-1a/2B subunits, Src reduces voltage-independent inhibition by the divalent cation Zn2+.	Zinc	140-144	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	46-50
10531471-2	1999	With recombinant receptors composed of NR1-1a/NR2A or NR1-1a/2B subunits, Src reduces voltage-independent inhibition by the divalent cation Zn2+.	Zinc	140-144	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-57
10531471-2	1999	With recombinant receptors composed of NR1-1a/NR2A or NR1-1a/2B subunits, Src reduces voltage-independent inhibition by the divalent cation Zn2+.	Zinc	140-144	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	74-77
10531471-3	1999	Thereby the function of recombinant NMDA receptors is potentiated by Src only when the Zn2+ level is sufficient to cause tonic inhibition.	Zinc	87-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	69-72
10531471-4	1999	Here we investigated whether the Src-induced potentiation of NMDA receptor function in neurons is caused by reducing voltage-independent Zn2+ inhibition.	Zinc	137-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-36
10531471-5	1999	Whereas chelating extracellular Zn2+ blocked the Src-induced potentiation of NR1-1a/2A receptors, we found that Zn2+ chelation did not affect the potentiation of NMDA receptor (NMDAR) currents by Src applied into hippocampal CA1 or CA3 neurons.	Zinc	32-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
10531471-5	1999	Whereas chelating extracellular Zn2+ blocked the Src-induced potentiation of NR1-1a/2A receptors, we found that Zn2+ chelation did not affect the potentiation of NMDA receptor (NMDAR) currents by Src applied into hippocampal CA1 or CA3 neurons.	Zinc	32-36	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	77-80
10568695-3	1999	Of the metals tested, Hg2+ and Zn2+ were the strongest inhibitors of mEH, while Cd2+ and Cu2+ were also strong inhibitors of sEH (I50 for all approximately 20 microM).	Zinc	31-35	epoxide hydrolase 1, microsomal	Mus musculus	69-72
10540391-1	1999	Streptomyces dizinc aminopeptidase (sAP) shows a specific activity of 33.7 nmol min(-1) mg(-1) toward the hydrolysis of the transition-state analogue bis-p-nitrophenylphosphate with a rate constant of k(cat)/K(m)=100 M(-1) s(-1) and a first-order rate enhancement of about 10(10), which is much superior to several Zn chemical models and comparable to some phosphodiesterases.	Zinc	315-317	carboxypeptidase Q	Homo sapiens	20-34
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	synaptotagmin 1	Rattus norvegicus	54-57
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	synaptotagmin 1	Rattus norvegicus	83-86
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	synaptotagmin 1	Rattus norvegicus	83-86
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	nitric oxide synthase 2	Rattus norvegicus	256-260
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	interleukin 1 beta	Rattus norvegicus	265-274
10487521-3	1999	To further elucidate the mechanism of growth suppression caused by p53-273L, we used squamous cell carcinoma cell line HSC3 to isolate subclones containing Zn2+-inducible wild-type (wt) p53, p53-175H, and p53-273L.	Zinc	156-160	tumor protein p53	Homo sapiens	186-189
10487521-3	1999	To further elucidate the mechanism of growth suppression caused by p53-273L, we used squamous cell carcinoma cell line HSC3 to isolate subclones containing Zn2+-inducible wild-type (wt) p53, p53-175H, and p53-273L.	Zinc	156-160	tumor protein p53	Homo sapiens	186-189
10487521-3	1999	To further elucidate the mechanism of growth suppression caused by p53-273L, we used squamous cell carcinoma cell line HSC3 to isolate subclones containing Zn2+-inducible wild-type (wt) p53, p53-175H, and p53-273L.	Zinc	156-160	tumor protein p53	Homo sapiens	186-189
10428786-0	1999	Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p.	Zinc	27-29	oleate-activated transcription factor OAF1	Saccharomyces cerevisiae S288C	61-66
10428786-0	1999	Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p.	Zinc	27-29	oleate-activated transcription factor PIP2	Saccharomyces cerevisiae S288C	71-76
10428786-4	1999	Induction is dependent on the Zn(2)Cys(6) family members Oaf1p and Pip2p, which bind to this element as a heterodimer.	Zinc	30-32	oleate-activated transcription factor OAF1	Saccharomyces cerevisiae S288C	57-62
10428786-4	1999	Induction is dependent on the Zn(2)Cys(6) family members Oaf1p and Pip2p, which bind to this element as a heterodimer.	Zinc	30-32	oleate-activated transcription factor PIP2	Saccharomyces cerevisiae S288C	67-72
10621945-25	1999	In spite of the fact that zinc (Zn) may act as a potent inhibitor of the NMDA receptor channel, high Zn doses accelerate A beta fibril formation, stabilize the beta-sheet conformation and thereby potentiate A beta neurotoxicity.	Zinc	101-103	amyloid beta precursor protein	Homo sapiens	121-127
10621945-25	1999	In spite of the fact that zinc (Zn) may act as a potent inhibitor of the NMDA receptor channel, high Zn doses accelerate A beta fibril formation, stabilize the beta-sheet conformation and thereby potentiate A beta neurotoxicity.	Zinc	101-103	amyloid beta precursor protein	Homo sapiens	207-213
10423240-0	1999	Zn(2+) ions selectively induce antimicrobial salivary peptide histatin-5 to fuse negatively charged vesicles.	Zinc	0-2	histatin 3	Homo sapiens	62-72
10407157-6	1999	Circular dichroism spectral data in trifluoroethanol showed that while the TIMP control peptide, CLPREPGL, bound only Zn(2+), the other four peptides bound both Ca(2+) and Zn(2+) with definite stoichiometries.	Zinc	118-120	TIMP metallopeptidase inhibitor 1	Homo sapiens	75-79
10407157-7	1999	Ca(2+) could displace Zn(2+) in the substrate peptides while Zn(2+) displaced Ca(2+) in the TIMP peptide.	Zinc	61-67	TIMP metallopeptidase inhibitor 1	Homo sapiens	92-96
18967665-5	1999	It was shown that ligand substitution kinetic methods coupled to three-way chemometric analytical methods can be used for the development of robust sensors for the analysis of binary [Zn(II)+Ni(II), Pb(II)+Cd(II), Zn(II)+Pb(II)] or ternary [Zn(II)+Pb(II)+Co(II)] mixtures of metal ions in the micromolar concentration range.	Zinc	184-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-261
10581245-5	1999	ATP and Zn(2+) enhance CRT"s ability to suppress aggregation of non- glycoproteins, whereas engagement of its lectin site with purified oligosaccharide attenuates this function.	Zinc	8-14	calreticulin	Homo sapiens	23-26
10564177-2	1999	To study the mechanisms responsible for metal-induced activation of ERK, we examined the effect of noncytotoxic exposures to As, Cu, V, or Zn on the kinases upstream of ERK in the epidermal growth factor (EGF) receptor signaling pathway.	Zinc	139-141	mitogen-activated protein kinase 1	Homo sapiens	169-172
10564177-6	1999	Immunoprecipitation studies demonstrated that As, Cu, V, or Zn induces EGF receptor phosphorylation.	Zinc	60-62	epidermal growth factor receptor	Homo sapiens	71-83
10564177-10	1999	Together, these data demonstrate that As, Cu, V, and Zn can activate the EGF receptor signaling pathway in BEAS cells and suggest that this mechanism may be involved in pulmonary responses to metal inhalation.	Zinc	53-55	epidermal growth factor receptor	Homo sapiens	73-85
10484340-1	1999	The influence of Zn on the expression of the apolipoprotein A-I (apoA-I) gene in Hep G2 cells was examined.	Zinc	17-19	apolipoprotein A1	Homo sapiens	45-63
10484340-1	1999	The influence of Zn on the expression of the apolipoprotein A-I (apoA-I) gene in Hep G2 cells was examined.	Zinc	17-19	apolipoprotein A1	Homo sapiens	65-71
10484340-6	1999	Similarly, the OP-Zn treatment restored the cellular Zn and apoA-I mRNA levels.	Zinc	18-20	apolipoprotein A1	Homo sapiens	60-66
10484340-7	1999	Furthermore, one passage of culture with Zn-supplemented media in both the Opti and CHE systems resulted in higher cellular Zn and apoA-I mRNA levels than those for controls.	Zinc	41-43	apolipoprotein A1	Homo sapiens	131-137
10484340-8	1999	Most significantly, short-term high-Zn induction to normal cells markedly elevated the cellular Zn (3-fold) and apoA-I mRNA (5-fold) levels.	Zinc	36-38	apolipoprotein A1	Homo sapiens	112-118
10484340-9	1999	Data derived from this study strongly suggest that the expression of apoA-I is regulated by cellular Zn status.	Zinc	101-103	apolipoprotein A1	Homo sapiens	69-75
10468163-8	1999	Serum tumor necrosis factor-alpha levels were increased, although nonsignificantly, in mice that received either MEL or Zn supplementation.	Zinc	120-122	tumor necrosis factor	Mus musculus	6-33
10411671-6	1999	In AD epsilon 4 apoE allele carriers, we found significantly higher Zn, Cu and insulin serum concentrations.	Zinc	68-70	apolipoprotein E	Homo sapiens	16-20
10411671-9	1999	CONCLUSIONS: In AD we have found a significant association between higher serum Zn, Cu and insulin concentrations and the presence of an epsilon 4 apoE allele, but only greater serum Zn concentration appears to be an independent risk factor associated with the development of AD.	Zinc	80-82	apolipoprotein E	Homo sapiens	147-151
10416695-11	1999	Mice lacking MT I and II lose more endogenous Zn into the gut because of a relative failure of the pancreas to retain Zn.	Zinc	46-48	metallothionein 1	Mus musculus	13-24
10604188-4	1999	In intact cells, p53 protein activity is crucially dependent on the availability of Zn ions and is impaired by exposure to Cd, a metal which readily substitutes for Zn in a number of transcription factors.	Zinc	84-86	tumor protein p53	Homo sapiens	17-20
10604188-4	1999	In intact cells, p53 protein activity is crucially dependent on the availability of Zn ions and is impaired by exposure to Cd, a metal which readily substitutes for Zn in a number of transcription factors.	Zinc	165-167	tumor protein p53	Homo sapiens	17-20
10480490-6	1999	SB 203347 (at 0.1-10 microM final concentration) inhibited PLA2 enzymatic activity released by Zn++ -activated CHO cells by up to 60% (P<0.0001).	Zinc	95-99	phospholipase A2 group IB	Homo sapiens	59-63
10358054-3	1999	By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding site whose occupancy by Zn(II) prevented the receptor from activating a retinal G protein, Gt (Sheikh, S. P., Zvyaga, T. A. , Lichtarge, O., Sakmar, T. P., and Bourne, H. R. (1996) Nature 383, 347-350).	Zinc	162-164	rhodopsin	Homo sapiens	97-106
10361260-6	1999	Our studies have also reported the suppressive effects of micromolar concentrations of Zn on caspase-3 activation in cell-free models.	Zinc	87-89	caspase 3	Homo sapiens	93-102
10376783-1	1999	OBJECTIVE: The objective of our study was to investigate zinc (Zn) status and effects of Zn supplementation in relation to insulin-like growth factor-I (IGF-I) and iron deficiency anemia in pregnant women.	Zinc	89-91	insulin like growth factor 1	Homo sapiens	123-151
10376783-1	1999	OBJECTIVE: The objective of our study was to investigate zinc (Zn) status and effects of Zn supplementation in relation to insulin-like growth factor-I (IGF-I) and iron deficiency anemia in pregnant women.	Zinc	89-91	insulin like growth factor 1	Homo sapiens	153-158
10376783-9	1999	There were significant positive correlations between increases in IGF-I and increases in Hb and RBC in the Zn administered groups.	Zinc	107-109	insulin like growth factor 1	Homo sapiens	66-71
10367894-3	1999	The core secondary structures are similar to a rabphilin-3A Zn2+-binding domain and to the C1 and LIM domains.	Zinc	60-64	rabphilin 3A	Homo sapiens	47-59
10421455-4	1999	Different metal-associated forms of the enzyme have demonstrated varying hydrolytic capabilities for each of the OP neurotoxins, and the activity of OPH (Co2+) is consistently higher than that of OPH (Zn2+) by five- to 20-fold.	Zinc	201-205	acylaminoacyl-peptide hydrolase	Homo sapiens	149-152
10421455-4	1999	Different metal-associated forms of the enzyme have demonstrated varying hydrolytic capabilities for each of the OP neurotoxins, and the activity of OPH (Co2+) is consistently higher than that of OPH (Zn2+) by five- to 20-fold.	Zinc	201-205	acylaminoacyl-peptide hydrolase	Homo sapiens	196-199
10216093-2	1999	Here, we demonstrate that Zn2+ can induce the adhesion of myelomonocytic cells to the endothelium, as well as to the provisional matrix proteins vitronectin (VN) and fibrinogen (FBG), which are pivotal steps for the recruitment of leukocytes into inflamed/injured tissue.	Zinc	26-30	fibrinogen beta chain	Homo sapiens	166-176
10212220-5	1999	Biglycan, a proteoglycan that is structurally closely related to decorin contains a similar high affinity Zn2+-binding segment, whereas the structurally more distantly related proteoglycans, epiphycan and osteoglycin, do not bind Zn2+ with high affinity.	Zinc	106-110	biglycan	Homo sapiens	0-8
10212220-5	1999	Biglycan, a proteoglycan that is structurally closely related to decorin contains a similar high affinity Zn2+-binding segment, whereas the structurally more distantly related proteoglycans, epiphycan and osteoglycin, do not bind Zn2+ with high affinity.	Zinc	230-234	biglycan	Homo sapiens	0-8
10342283-5	1999	Immunohistochemistry using a guinea pig antiserum against a synthetic polypeptide of canine MT-III demonstrated positive MT-III immunoreactivity predominantly in neurons in the Zn-rich regions such as hippocampus and parahippocampus.	Zinc	177-179	transcription initiation factor TFIID subunit 4	Canis lupus familiaris	92-98
10409234-6	1999	NO donor) diminished Zn(2+)-induced and uninduced CFTR protein levels by 43.3 +/- 5.1 and 34.4 +/- 17.1% from their corresponding control values, respectively.	Zinc	21-27	CF transmembrane conductance regulator	Homo sapiens	50-54
10194381-4	1999	We employed a novel in vitro filtration assay for detecting zinc(II)- and copper(II)-induced aggregation of A beta in solutions containing concentrations of the peptide that are similar to those reported for human cerebrospinal fluid.	Zinc	60-68	amyloid beta precursor protein	Homo sapiens	108-114
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	68-70	superoxide dismutase 1	Homo sapiens	71-74
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	68-70	superoxide dismutase 1	Homo sapiens	186-189
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	68-70	superoxide dismutase 1	Homo sapiens	186-189
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	183-185	superoxide dismutase 1	Homo sapiens	71-74
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	183-185	superoxide dismutase 1	Homo sapiens	186-189
10319417-6	1999	These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.	Zinc	183-185	superoxide dismutase 1	Homo sapiens	186-189
10408635-12	1999	Supplementing zinc (12 mg Zn++/day) for one month in infected elderly subjects and HAART therapy in HIV+ subjects reduces risk scores in CD4+ and zincaemia deficiencies for infections relapse, suggesting that the zinc beneficial effect may be independent either by HIV-virus or pathogen agents involved.	Zinc	26-28	CD4 molecule	Homo sapiens	137-140
10342283-5	1999	Immunohistochemistry using a guinea pig antiserum against a synthetic polypeptide of canine MT-III demonstrated positive MT-III immunoreactivity predominantly in neurons in the Zn-rich regions such as hippocampus and parahippocampus.	Zinc	177-179	transcription initiation factor TFIID subunit 4	Canis lupus familiaris	121-127
10069047-0	1999	Determining anomericity of the glycosidic bond in Zn(II)-diethylenetriamine-disaccharide complexes using MSn in a quadrupole ion trap.	Zinc	50-56	moesin	Homo sapiens	105-108
10066772-10	1999	Biotin-HK specifically bound to rCK128 and rCK131 in the presence of Zn2+ but not to Deleted1-6rCK131.	Zinc	69-73	kininogen 1	Homo sapiens	7-9
10026247-1	1999	Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.	Zinc	69-73	S100 calcium binding protein A7	Homo sapiens	54-60
10026247-1	1999	Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.	Zinc	85-89	S100 calcium binding protein A7	Homo sapiens	54-60
10187914-7	1999	DNA-protein complex formation between the investigated rpL32 promoter fragment containing the GCC-element and human fibroblast nuclear proteins is Zn2+-dependent.	Zinc	147-151	ribosomal protein L32	Homo sapiens	55-60
9914326-3	1999	The current studies were intended to examine the hypothesis that this inactivation of ALP activity is caused by the dissociation of an active center Zn and that Pi inhibits that dissociation.	Zinc	149-151	alkaline phosphatase, placental	Homo sapiens	86-89
9914326-4	1999	Initial studies showed that Zn, like Pi, could increase ALP specific activity in human osteosarcoma SaOS-2 cells in a time- and dose-dependent manner (e.g., a 50% increase at 0.2 micromol/liter Zn, P < 0.005).	Zinc	28-30	alkaline phosphatase, placental	Homo sapiens	56-59
9914326-6	1999	Zn also increased ALP specific activity in (human osteosarcoma) MG-63 cells and in cells derived from normal human vertebrae (P < 0.001 for each).	Zinc	0-2	alkaline phosphatase, placental	Homo sapiens	18-21
9914326-7	1999	The effect of Zn to increase ALP activity was not associated with parallel increases in total protein synthesis, collagen production, or tartrate-resistant acid phosphatase activity (no change in any of these indices), net IGF-2 synthesis (a Zn-dependent decrease, P < 0.005), or PTH-dependent synthesis of cAMP (a biphasic increase, P < 0.02).	Zinc	14-16	alkaline phosphatase, placental	Homo sapiens	29-32
9914326-8	1999	Kinetic studies of Pi and Zn as co-effectors of ALP activity showed that Zn was a mixed-type effector with respect to Pi, whereas Pi was competitive with respect to Zn.	Zinc	26-28	alkaline phosphatase, placental	Homo sapiens	48-51
9914326-8	1999	Kinetic studies of Pi and Zn as co-effectors of ALP activity showed that Zn was a mixed-type effector with respect to Pi, whereas Pi was competitive with respect to Zn.	Zinc	73-75	alkaline phosphatase, placental	Homo sapiens	48-51
9914326-8	1999	Kinetic studies of Pi and Zn as co-effectors of ALP activity showed that Zn was a mixed-type effector with respect to Pi, whereas Pi was competitive with respect to Zn.	Zinc	73-75	alkaline phosphatase, placental	Homo sapiens	48-51
9914326-9	1999	Mechanistic studies showed that (1) Zn reversed the effect of Pi withdrawal to decrease ALP activity, but not by reactivating inactive ALP protein (the process required protein synthesis, without increases in ALP mRNA or the level of ALP immunoreactive protein); (2) Zn increased the half-life of ALP activity in intact cells and after a partial purification; and (3) Pi inhibited the process of ALP inactivation by EDTA (which chelates active center Zn).	Zinc	36-38	alkaline phosphatase, placental	Homo sapiens	88-91
9914326-10	1999	All these findings are consistent with the general hypothesis that Pi increases the half-life of skeletal ALP by preventing the dissociation of active center Zn and with a mechanistic model of skeletal ALP activity in which active center Zn participates in Pi-ester binding and/or hydrolysis.	Zinc	158-160	alkaline phosphatase, placental	Homo sapiens	106-109
9914326-10	1999	All these findings are consistent with the general hypothesis that Pi increases the half-life of skeletal ALP by preventing the dissociation of active center Zn and with a mechanistic model of skeletal ALP activity in which active center Zn participates in Pi-ester binding and/or hydrolysis.	Zinc	238-240	alkaline phosphatase, placental	Homo sapiens	106-109
9914326-10	1999	All these findings are consistent with the general hypothesis that Pi increases the half-life of skeletal ALP by preventing the dissociation of active center Zn and with a mechanistic model of skeletal ALP activity in which active center Zn participates in Pi-ester binding and/or hydrolysis.	Zinc	238-240	alkaline phosphatase, placental	Homo sapiens	202-205
9726991-3	1998	Mac1-(1-159) purified from Escherichia coli contains two bound Zn(II) ions.	Zinc	63-69	Mac1p	Saccharomyces cerevisiae S288C	0-4
10213468-3	1999	This DTPA-pullulan could conjugate with IFN through Zn2+ coordination on mixing these three components.	Zinc	52-56	interferon alpha 1	Homo sapiens	40-43
10213468-4	1999	Intravenous injection of the IFN-DTPA-pullulan conjugate with Zn2+ coordination induced activity in the liver of an antiviral enzyme.	Zinc	62-66	interferon alpha 1	Homo sapiens	29-32
10213468-7	1999	Liver targeting of IFN by this conjugation technique based on Zn2+ coordination opens a new method of IFN therapy.	Zinc	62-66	interferon alpha 1	Homo sapiens	19-22
10213468-7	1999	Liver targeting of IFN by this conjugation technique based on Zn2+ coordination opens a new method of IFN therapy.	Zinc	62-66	interferon alpha 1	Homo sapiens	102-105
9949729-1	1999	Electrospray mass spectrometry is used at pH 8.0 in combination with accurate mass measurements to confirm the multiplicity of insulin in stable noncovalent complexes with Zn(II) ions.	Zinc	172-174	insulin	Homo sapiens	127-134
9989274-12	1999	Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs.	Zinc	73-77	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	135-146
9882439-6	1999	The enzymatic activity of purified GPI-PLD, which was depleted of divalent cations by pretreatment with EDTA, EGTA, or 1, 10-phenanthroline, could be completely restored with Zn2+ (and partially with Co2+), which indicates that Ca2+ can be removed from the protein without affecting its enzymatic activity.	Zinc	175-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-42
10811533-2	1999	In this study, we investigated the modulatory effects of the heavy metal Zn2+ on transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in primary rat hepatocytes.	Zinc	73-77	transforming growth factor, beta 1	Rattus norvegicus	81-113
10811533-2	1999	In this study, we investigated the modulatory effects of the heavy metal Zn2+ on transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in primary rat hepatocytes.	Zinc	73-77	transforming growth factor, beta 1	Rattus norvegicus	115-124
10811533-4	1999	Pretreatment with 100 micromol/L Zn2+ abrogated the nuclear condensation, in situ end-labeling, and DNA laddering in TGF-beta1-treated hepatocytes.	Zinc	33-37	transforming growth factor beta 1	Homo sapiens	117-126
10811533-6	1999	These data provide evidence that Zn2+ exerts its effects on the endonucleases that act downstream in the execution phase of TGF-beta1-induced apoptosis in hepatocytes.	Zinc	33-37	transforming growth factor beta 1	Homo sapiens	124-133
9863712-2	1998	We have studied the effect of different concentrations (0-20 micromol/l) of zinc ions (Zn2+) in the absence and presence of calcium on the gel structure formed in purified fibrinogen-enzyme systems.	Zinc	87-91	fibrinogen beta chain	Homo sapiens	172-182
10087468-1	1999	The therapeutic actions of captopril are facilitated by its sulfhydryl moiety which interacts with the metal (Zn2+) prosthetic groups of angiotensin-converting enzyme (ACE; EC 3.4.15.1).	Zinc	110-114	angiotensin I converting enzyme	Homo sapiens	137-166
10087468-1	1999	The therapeutic actions of captopril are facilitated by its sulfhydryl moiety which interacts with the metal (Zn2+) prosthetic groups of angiotensin-converting enzyme (ACE; EC 3.4.15.1).	Zinc	110-114	angiotensin I converting enzyme	Homo sapiens	168-171
9925766-1	1999	S100B (S100beta) and S100A6 (calcyclin) are two 10-kDa Ca2+- and Zn2+-binding proteins coexpressed in melanoma and cell-cycle regulated.	Zinc	65-69	S100 calcium binding protein B	Homo sapiens	0-5
9925766-1	1999	S100B (S100beta) and S100A6 (calcyclin) are two 10-kDa Ca2+- and Zn2+-binding proteins coexpressed in melanoma and cell-cycle regulated.	Zinc	65-69	S100 calcium binding protein B	Homo sapiens	7-15
9925766-1	1999	S100B (S100beta) and S100A6 (calcyclin) are two 10-kDa Ca2+- and Zn2+-binding proteins coexpressed in melanoma and cell-cycle regulated.	Zinc	65-69	S100 calcium binding protein A6	Homo sapiens	21-27
9925766-1	1999	S100B (S100beta) and S100A6 (calcyclin) are two 10-kDa Ca2+- and Zn2+-binding proteins coexpressed in melanoma and cell-cycle regulated.	Zinc	65-69	S100 calcium binding protein A6	Homo sapiens	29-38
9925766-7	1999	S100B and S100A6 were coimmunoprecipitated from melanoma cell lysates in the presence of 100 microM Zn2+.	Zinc	100-104	S100 calcium binding protein B	Homo sapiens	0-5
9925766-7	1999	S100B and S100A6 were coimmunoprecipitated from melanoma cell lysates in the presence of 100 microM Zn2+.	Zinc	100-104	S100 calcium binding protein A6	Homo sapiens	10-16
9872993-6	1999	We show that Zn2+ induction of a stably transfected, metallothionein promoter-regulated mxi1 gene blocked the ability of serum to induce transcription of the endogenous c-myc gene and cell entry into S phase.	Zinc	13-17	MAX interactor 1, dimerization protein	Homo sapiens	88-92
10563042-5	1999	Fluorimetric detection showed good detection limits, but interferences from cations such as Mg2+ and Zn2+ required the use of the longer CS2 ion exchange column.	Zinc	101-105	calsyntenin 2	Homo sapiens	137-140
10811533-0	1999	A reappraisal of the role of Zn2+ in TGF-beta1-induced apoptosis in primary hepatocytes.	Zinc	29-33	transforming growth factor beta 1	Homo sapiens	37-46
12114769-8	1999	These results indicate that Cu,Zn-SOD and Mu-SOD may play different roles as a scavenger or antioxidants in normal human adrenal glands, i.e., Cu,Zn-SOD as a scavenger of toxic superoxide radicals generated during steroidogenesis and Mn-SOD during catecholamine production.	Zinc	31-33	superoxide dismutase 1	Homo sapiens	34-37
9987035-7	1999	Pretreatment with insulin or brain-derived neurotrophic factor increased the Zn(2+)-induced free radical injury.	Zinc	77-83	insulin	Homo sapiens	18-25
9886489-13	1999	After stable transfection with human NHE-1 in a vector utilizing the metallothionein promoter, overnight induction with Zn(2+)increased the NHE activity and its sensitivity to amiloride only in the basolateral membrane in OK7a cells.	Zinc	120-122	solute carrier family 9 member A1	Homo sapiens	37-42
18472906-1	1999	The inverse relationship between zinc (Zn(++)) and prolactin (PRL) was detected in in vitro studies, whereas in vivo results are contradictory.	Zinc	39-45	prolactin	Homo sapiens	62-65
18472906-3	1999	Basal serum Zn(++) levels and serum PRL response to acute and chronic oral Zn(++) administration were evaluated in seven patients with prolactinomas and one with idiopathic hyperprolactinemia.	Zinc	75-81	prolactin	Homo sapiens	36-39
18472906-5	1999	ZnZn(++) administration (47.7 mg daily) during 60 days increased serum Zn(++) levels from 1.11 +/- 0.15 to 1.59 +/- 0.58 mug/mL (p < 0.05) but caused no change in serum PRL levels.	Zinc	2-8	prolactin	Homo sapiens	172-175
9858586-7	1999	In COS cells, the expressed p235 N-terminal but not the C-terminal region displayed a vesicular pattern similar to that in 3T3-L1 adipocytes that became diffuse upon Zn2+ chelation or FYVE finger truncation.	Zinc	166-170	phosphoinositide kinase, FYVE type zinc finger containing	Mus musculus	28-32
9858586-10	1999	In conclusion, the mouse p235 protein determines an important novel class of phosphoinositide kinases that seems to be targeted to specific intracellular loci by a Zn-dependent mechanism.	Zinc	164-166	phosphoinositide kinase, FYVE type zinc finger containing	Mus musculus	25-29
10087459-6	1999	Lower serum Zn in detoxified AWLD patients was attributable to lowered serum Alb.	Zinc	12-14	albumin	Homo sapiens	77-80
10087459-9	1999	The results show that there is an in vivo activation of the inflammatory response system in detoxified AWLD patients and that lower serum Zn may be causally related to lower serum Alb.	Zinc	138-140	albumin	Homo sapiens	180-183
9830036-4	1998	In an in vitro binding reaction, Zn2+ mediates p56(lck) association with a glutathione S-transferase (GST) fusion protein containing the cytosolic domains of CD4 or CD8alpha; no other metals tested support binding.	Zinc	33-37	CD4 molecule	Homo sapiens	158-161
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	CD4 molecule	Homo sapiens	27-30
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	CD4 molecule	Homo sapiens	162-165
9850069-11	1998	In addition, the expression of bax protein, an apoptosis accelerator, was markedly stronger in esophagi from Zn-/DFMO+ animals that showed increased apoptosis, whereas increased expression of bcl-2, an inhibitor of apoptosis, was only seen in the highly proliferative, zinc-deficient esophagus (Zn-/DFMO-).	Zinc	109-111	BCL2, apoptosis regulator	Rattus norvegicus	192-197
9831543-5	1998	Treatment of HPT cells with Cd2+, Zn2+, or Cu2+ increased the levels of MT-1E and MT-1A mRNA, but not the levels of MT-1X or MT-1F mRNA.	Zinc	34-38	metallothionein 1A	Homo sapiens	82-87
9831543-5	1998	Treatment of HPT cells with Cd2+, Zn2+, or Cu2+ increased the levels of MT-1E and MT-1A mRNA, but not the levels of MT-1X or MT-1F mRNA.	Zinc	34-38	metallothionein 1X	Homo sapiens	116-121
9832138-5	1998	We found that fura-2 was useful in measuring small increases in [Zn2+]i associated with exposure to Zn2+ alone that may be mediated by a Na+/Ca2+ exchanger.	Zinc	65-69	solute carrier family 8 member A1	Homo sapiens	137-155
9832138-5	1998	We found that fura-2 was useful in measuring small increases in [Zn2+]i associated with exposure to Zn2+ alone that may be mediated by a Na+/Ca2+ exchanger.	Zinc	100-104	solute carrier family 8 member A1	Homo sapiens	137-155
9924995-4	1998	Cofactors such as Zn2+ were found to induce deaggregation of Abeta instead of aggregation.	Zinc	18-22	amyloid beta precursor protein	Homo sapiens	61-66
9728050-6	1998	Similarly, the transcription factors c-Jun and ATF-2, substrates of JNK and P38, respectively, were markedly phosphorylated in BEAS cells treated with As, Cr, Cu, V, and Zn.	Zinc	170-172	mitogen-activated protein kinase 8	Homo sapiens	68-71
11670592-4	1998	The zinc(II) complex Zn(II)(OEBOMe), where OEBOMe is the dianion of octaethylmethoxybiliverdin, is sufficiently stable to be isolated in crystalline form, but the cobalt(II) analogue, Co(II)(OEBOMe), is less stable and has been characterized primarily by (1)H NMR spectroscopy in solution.	Zinc	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-198
11670592-4	1998	The zinc(II) complex Zn(II)(OEBOMe), where OEBOMe is the dianion of octaethylmethoxybiliverdin, is sufficiently stable to be isolated in crystalline form, but the cobalt(II) analogue, Co(II)(OEBOMe), is less stable and has been characterized primarily by (1)H NMR spectroscopy in solution.	Zinc	21-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-198
9728050-4	1998	Activity assays confirmed marked activation of ERK, JNK, and P38 in BEAS cells exposed to As, V, and Zn.	Zinc	101-103	mitogen-activated protein kinase 8	Homo sapiens	52-55
9728050-4	1998	Activity assays confirmed marked activation of ERK, JNK, and P38 in BEAS cells exposed to As, V, and Zn.	Zinc	101-103	mitogen-activated protein kinase 14	Homo sapiens	61-64
9728050-6	1998	Similarly, the transcription factors c-Jun and ATF-2, substrates of JNK and P38, respectively, were markedly phosphorylated in BEAS cells treated with As, Cr, Cu, V, and Zn.	Zinc	170-172	mitogen-activated protein kinase 14	Homo sapiens	76-79
9728050-7	1998	The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells.	Zinc	37-39	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9745529-0	1998	Anti-rat IL-8 (CINC) monoclonal antibody administration reduces ischemia-reperfusion injury in small intestine.	Zinc	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
9758163-7	1998	The neuropeptide release elicited by D-serine was strongly inhibited by ifenprodil (0.3 microM) and by Zn2+ ions (50 nM), selective ligands at the NR2B and NR2A subunits of NMDA receptors, respectively.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	156-160
9761477-5	1998	Extended X-ray absorption fine structure (EXAFS) spectra collected on the zinc associated minimal DNA-binding domain of XPA (ZnXPA-MBD) show directly, for the first time, that the zinc is coordinated to the sulfur atoms of four cysteine residues with an average Zn-S bond length of 2.34+/-0.01 A.	Zinc	262-266	XPA, DNA damage recognition and repair factor	Homo sapiens	120-123
10696239-4	1998	Recently, the yeast two-hybrid system has identified hASNA-I as a cellular partner of metallothionein II suggesting an additional role in Zn homeostasis and cellular detoxification.	Zinc	138-140	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	53-60
9692986-3	1998	The d-d electronic transitions of the Co(II)-substituted hexamer give optical signatures of the T to R transition which can be quantified, but the "spectroscopically silent" character of Zn(II) has made previous attempts to describe the Zn(II) species difficult.	Zinc	187-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9793465-8	1998	In the kidney, Pb and the Pb + Zn combination were shown to produce a significant lowering of NS catalase activity, indicating a stabilization of peroxisomes.	Zinc	31-33	catalase	Rattus norvegicus	97-105
9705349-12	1998	Kinetic analysis of PAP-2a, -2b, and -2c activity against PA, lysophosphatidic acid, C1P, and S1P presented in mixed micelles of Triton X-100 revealed differences in substrate specificity and susceptibility to inhibition by sphingosine, Zn2+, and propranol.	Zinc	237-241	phospholipid phosphatase 1	Homo sapiens	20-31
9705292-7	1998	The activity of p48 could be stabilized by the addition of the divalent cations Mg2+ and Mn2+ but not Zn2+.	Zinc	102-106	interferon regulatory factor 9	Homo sapiens	16-19
9698310-2	1998	In this report we have investigated the role that the NR1 subunit plays in voltage-independent Zn2+ inhibition.	Zinc	95-99	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-57
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	48-51
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	199-202
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	257-261
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	48-51
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	199-202
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	257-261
9687495-7	1998	Thus, Zn2+ modulation could be conveyed to hNET by mutational transfer of only this residue.	Zinc	6-10	solute carrier family 6 member 2	Homo sapiens	43-47
9687495-8	1998	His375 conserved between hDAT and hNET, present in the fourth extracellular loop (ECL4) at the top of transmembrane segment VII, was identified as a second major coordinate for Zn2+ binding.	Zinc	177-181	solute carrier family 6 member 2	Homo sapiens	34-38
9692986-3	1998	The d-d electronic transitions of the Co(II)-substituted hexamer give optical signatures of the T to R transition which can be quantified, but the "spectroscopically silent" character of Zn(II) has made previous attempts to describe the Zn(II) species difficult.	Zinc	237-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9692986-7	1998	Using 4H3N as an indicator, these studies show that both LoA and LoB are made less favorable by the substitution of Co(II) for Zn(II); LoA is increased by 10-fold while LoB by 35-fold, whereas the ligand affinities of the phenolic pockets are unchanged.	Zinc	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
9685718-4	1998	In a cell-free system that consisted of a specific substrate for caspase-3 and a lysate of HL-60 cells that had been treated with 50 microM GGO, Zn2+ ions at concentrations above 0.1 mM inhibited the activity of caspase-3.	Zinc	145-149	caspase 3	Homo sapiens	65-74
9823438-3	1998	The purpose of this study was to investigate the activities of SOD-1 and glutathione peroxidase (GSH-Px) enzymes and the levels of their cofactors zinc (Zn), copper (Cu) and selenium (Se) in plasma of 20 Down syndrome patients.	Zinc	153-155	superoxide dismutase 1	Homo sapiens	63-68
9680177-13	1998	These results indicated that Cu2+, but not Mn2+, Zn2+, and Fe2+, causes the activation of eNOS, while Cu2+, Mn2+, Zn2+, and Fe2+ directly suppressed eNOS activity extracted from HPAEC.	Zinc	49-53	nitric oxide synthase 3	Homo sapiens	90-94
9680177-13	1998	These results indicated that Cu2+, but not Mn2+, Zn2+, and Fe2+, causes the activation of eNOS, while Cu2+, Mn2+, Zn2+, and Fe2+ directly suppressed eNOS activity extracted from HPAEC.	Zinc	114-118	nitric oxide synthase 3	Homo sapiens	90-94
9680177-13	1998	These results indicated that Cu2+, but not Mn2+, Zn2+, and Fe2+, causes the activation of eNOS, while Cu2+, Mn2+, Zn2+, and Fe2+ directly suppressed eNOS activity extracted from HPAEC.	Zinc	114-118	nitric oxide synthase 3	Homo sapiens	149-153
9685718-4	1998	In a cell-free system that consisted of a specific substrate for caspase-3 and a lysate of HL-60 cells that had been treated with 50 microM GGO, Zn2+ ions at concentrations above 0.1 mM inhibited the activity of caspase-3.	Zinc	145-149	caspase 3	Homo sapiens	212-221
9685718-5	1998	The effect of Zn2+ ions on the processing of caspase-3 during GGO-induced apoptosis was investigated by Western blotting, which revealed that an inactive 32-kDa precursor of caspase-3 was cleaved, in response to GGO, to yield an activated 17-kDa enzyme.	Zinc	14-18	caspase 3	Homo sapiens	45-54
9685718-5	1998	The effect of Zn2+ ions on the processing of caspase-3 during GGO-induced apoptosis was investigated by Western blotting, which revealed that an inactive 32-kDa precursor of caspase-3 was cleaved, in response to GGO, to yield an activated 17-kDa enzyme.	Zinc	14-18	caspase 3	Homo sapiens	174-183
9685718-6	1998	Treatment of HL-60 cells with Zn2+ ions inhibited the cleavage of the precursor by a protease that was induced by treatment with GGO, and inhibition of this processing was well correlated with the inhibition by Zn2+ ions of caspase-3 activity in the cell-free system.	Zinc	30-34	caspase 3	Homo sapiens	224-233
9685718-6	1998	Treatment of HL-60 cells with Zn2+ ions inhibited the cleavage of the precursor by a protease that was induced by treatment with GGO, and inhibition of this processing was well correlated with the inhibition by Zn2+ ions of caspase-3 activity in the cell-free system.	Zinc	211-215	caspase 3	Homo sapiens	224-233
9685718-7	1998	In cell-extracted cytosols, Zn2+ ions inhibited the cleavage of the 32-kDa precursor by caspase-9 (Aapf-3) that was activated by addition of cytochrome c and dATP.	Zinc	28-32	cytochrome c, somatic	Homo sapiens	141-153
9685718-8	1998	These results indicate that inhibition of GGO-induced apoptosis in HL-60 cells by Zn2+ ions might be due to inhibition by Zn2+ ions of the processing of a precursor to caspase-3.	Zinc	122-126	caspase 3	Homo sapiens	168-177
9658205-4	1998	We have investigated the actions of Zn2+ on two of the most abundant human excitatory amino acid transporters, EAAT1 and EAAT2.	Zinc	36-40	solute carrier family 1 member 3	Homo sapiens	111-116
9665796-3	1998	It has been claimed that inhibition of an OA-sensitive phosphatase, possibly of PP1, induces activation of a kinase which is sensitive to staurosporine and Zn2+.	Zinc	156-160	inorganic pyrophosphatase 1	Homo sapiens	80-83
9715420-3	1998	Lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha) stimulated different liver cell populations to produce CINC; LPS mainly stimulated Kupffer cells.	Zinc	154-158	tumor necrosis factor	Rattus norvegicus	50-59
9715420-3	1998	Lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha) stimulated different liver cell populations to produce CINC; LPS mainly stimulated Kupffer cells.	Zinc	154-158	interleukin 1 alpha	Rattus norvegicus	66-85
9715420-3	1998	Lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha) stimulated different liver cell populations to produce CINC; LPS mainly stimulated Kupffer cells.	Zinc	154-158	interleukin 1 alpha	Rattus norvegicus	87-97
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	91-95	solute carrier family 1 member 3	Homo sapiens	171-176
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	219-223	solute carrier family 1 member 3	Homo sapiens	72-77
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	219-223	solute carrier family 1 member 2	Homo sapiens	82-87
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	219-223	solute carrier family 1 member 3	Homo sapiens	171-176
9658205-9	1998	Mutation of this glycine residue in EAAT2 to histidine generates a Zn2+ sensitive transporter, further confirming the role of this residue in conferring differential Zn2+ sensitivity.	Zinc	67-71	solute carrier family 1 member 2	Homo sapiens	36-41
9684789-4	1998	Maximal PK activation required the addition of 250 microM or 10 microM Zn2+ to buffers containing bovine serum albumin (BSA) or gelatin, respectively.	Zinc	71-75	albumin	Homo sapiens	105-118
9667777-6	1998	The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.	Zinc	116-118	amyloid beta precursor protein	Homo sapiens	150-162
9603947-12	1998	Furthermore, ASM-2 requires addition of Zn2+ to be fully active, whereas ASM-1 is active in the absence of cation.	Zinc	40-44	Sphingomyelin phosphodiesterase 2	Caenorhabditis elegans	13-18
9592168-3	1998	A three-dimensional structure for XPA-MBD was generated using distance geometry and simulated annealing methods from NOE-based distance restraints, hydrogen bond and Zn-S distance restraints, and dihedral restraints.	Zinc	166-168	XPA, DNA damage recognition and repair factor	Homo sapiens	34-37
9582309-2	1998	Previously, in appraising the effects of different neurochemical factors that impact upon the solubility of Abeta, we observed that Zn2+ was the predominant bioessential metal to induce the aggregation of soluble Abeta at pH 7.4 in vitro and that this reaction is totally reversible with chelation.	Zinc	132-136	amyloid beta precursor protein	Homo sapiens	108-113
9582309-2	1998	Previously, in appraising the effects of different neurochemical factors that impact upon the solubility of Abeta, we observed that Zn2+ was the predominant bioessential metal to induce the aggregation of soluble Abeta at pH 7.4 in vitro and that this reaction is totally reversible with chelation.	Zinc	132-136	amyloid beta precursor protein	Homo sapiens	213-218
9582309-10	1998	Since a mildly acidic environment together with increased Zn2+ and Cu2+ are common features of inflammation, we propose that Abeta aggregation by these factors may be a response to local injury.	Zinc	58-62	amyloid beta precursor protein	Homo sapiens	125-130
9582309-11	1998	Cu2+, Zn2+, and Fe3+ association with Abeta explains the recently reported enrichment of these metal ions in amyloid plaques in Alzheimer"s disease.	Zinc	6-10	amyloid beta precursor protein	Homo sapiens	38-43
9626889-1	1998	Transmetallation between commercially available solutions of gadolinium (Gd) chelates and the zinc (Zn)-dependent angiotensin-converting enzyme (ACE) was investigated.	Zinc	100-102	angiotensin I converting enzyme	Homo sapiens	145-148
9663788-1	1998	Neutral endopeptidase-24.11 (NEP, EC 3.4.24.11) is a cell surface Zn metallopeptidase that hydrolyzes bioactive regulatory peptides.	Zinc	66-68	membrane metalloendopeptidase	Homo sapiens	0-27
9663788-1	1998	Neutral endopeptidase-24.11 (NEP, EC 3.4.24.11) is a cell surface Zn metallopeptidase that hydrolyzes bioactive regulatory peptides.	Zinc	66-68	membrane metalloendopeptidase	Homo sapiens	29-32
9658205-4	1998	We have investigated the actions of Zn2+ on two of the most abundant human excitatory amino acid transporters, EAAT1 and EAAT2.	Zinc	36-40	solute carrier family 1 member 2	Homo sapiens	121-126
9658205-5	1998	Zn2+ is a noncompetitive, partial inhibitor of glutamate transport by EAAT1 with an IC50 value of 9.9 +/- 2.3 microM and has no effect on glutamate transport by EAAT2 at concentrations up to 300 microM.	Zinc	0-4	solute carrier family 1 member 3	Homo sapiens	70-75
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	91-95	solute carrier family 1 member 3	Homo sapiens	72-77
9658205-7	1998	We have investigated the molecular basis for differential inhibition of EAAT1 and EAAT2 by Zn2+ using site-directed mutagenesis and demonstrate that histidine residues of EAAT1 at positions 146 and 156 form part of the Zn2+ binding site.	Zinc	91-95	solute carrier family 1 member 2	Homo sapiens	82-87
9578461-0	1998	Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin.	Zinc	9-13	S100 calcium binding protein A6	Homo sapiens	91-100
9620287-0	1998	Construction of temperature and Zn-dependent human stromal cell lines that amplify hematopoietic precursors from cord blood CD34+ cells.	Zinc	32-34	CD34 molecule	Homo sapiens	124-128
9578461-3	1998	Ca2+ and Zn2+ binding properties of CaCY were examined with respect to the oxidation state of the single Cys residue at position 3.	Zinc	9-13	S100 calcium binding protein A6	Homo sapiens	36-40
9578461-8	1998	Fully reduced CaCY binds Zn2+ with an affinity of at least 1.0x10(7) M(-1).	Zinc	25-29	S100 calcium binding protein A6	Homo sapiens	14-18
9578461-11	1998	The reactivity of Cys3 is reduced by Zn2+ binding, although oxidized CaCY still binds Zn2+.	Zinc	86-90	S100 calcium binding protein A6	Homo sapiens	69-73
9485322-8	1998	In this paper, we report that S100B(beta beta) binds to the p53 peptide (CaK3 < or = 23.5 +/- 6.6 microM) in a Ca(2+)-dependent manner, and that the presence of the p53 peptide was found to increase the binding affinity of Ca2+ to S100B(beta beta) by 3-fold using EPR and PRR methods, whereas the peptide had no effect on Zn2+ binding to S100B(beta beta).	Zinc	325-329	S100 calcium binding protein B	Homo sapiens	30-35
9550453-1	1998	The relationship between diabetes, insulin and zinc (Zn) is complex with no clear cause and effect relationships.	Zinc	53-55	insulin	Homo sapiens	35-42
9550453-6	1998	Since Zn plays a clear role in the synthesis, storage and secretion of insulin as well as conformational integrity of insulin in the hexameric form, the decreased Zn, which affects the ability of the islet cell to produce and secrete insulin, might then compound the problem, particularly in Type 2 diabetes.	Zinc	6-8	insulin	Homo sapiens	71-78
9546200-2	1998	It was established that strongly bound water molecules are already present in Zn-free insulin.	Zinc	78-80	insulin	Homo sapiens	86-93
18967073-4	1998	Thus, it is possible to have a separation of Zn(II) of Co(II) when [NH(4)SCN] is 0.5 mol l(-1) and [H(2)SO(4)] is about 2 mol l(-1).	Zinc	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
9485322-8	1998	In this paper, we report that S100B(beta beta) binds to the p53 peptide (CaK3 < or = 23.5 +/- 6.6 microM) in a Ca(2+)-dependent manner, and that the presence of the p53 peptide was found to increase the binding affinity of Ca2+ to S100B(beta beta) by 3-fold using EPR and PRR methods, whereas the peptide had no effect on Zn2+ binding to S100B(beta beta).	Zinc	325-329	tumor protein p53	Homo sapiens	60-63
9543248-4	1998	Thus, the present study was undertaken to investigate whether Zn2+ inhibits production of inducible NO synthase and/or constitutive NO synthase activity to produce NO.	Zinc	62-66	nitric oxide synthase 2	Rattus norvegicus	90-111
9506261-9	1998	Both Zn(2+)- and ZnO-induced CL was inhibited by manoalide, a phospholipase A2 inhibitor, with IC50 of 0.25 microM and 0.66 microM respectively.	Zinc	5-11	phospholipase A2 group IB	Homo sapiens	62-78
9543248-11	1998	Thus, our results indicate that Zn2+ is capable of inhibiting lipopolysaccharide- or interleukin-1beta-induced NO formation as well as NO formation by constitutive NO synthase basally or in response to bradykinin or A-23187, and may explain the reported anti-inflammatory activity of Zn2+.	Zinc	32-36	interleukin 1 beta	Rattus norvegicus	85-102
9498330-5	1998	Zn level in MT-I* also increased from 8.43 microg/g (day 1) to 20.7 microg/g (day 60) with age.	Zinc	0-2	metallothionein 1	Mus musculus	12-17
9649687-3	1998	The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes.	Zinc	68-70	interferon gamma	Homo sapiens	110-137
9407319-11	1998	Both Cd and Zn resulted in significantly increased levels of MT mRNA in chondrocyte cell cultures.	Zinc	12-14	metallothionein 4	Gallus gallus	61-63
9509420-2	1997	When plasmid DNA was incubated with 5 microM Cu, Zn-SOD and 1.0 mM H2O2, DNA cleavage occurred within 15 min.	Zinc	49-51	superoxide dismutase 1	Homo sapiens	52-55
9509420-6	1997	Incubation with H2O2 resulted in a time-dependent release of copper ions from the Cu,Zn-SOD molecule.	Zinc	85-87	superoxide dismutase 1	Homo sapiens	88-91
9509420-9	1997	We suggest that DNA cleavage is mediated in the Cu,Zn-SOD/H2O2 system via the generation of .OH by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper ions released from oxidatively damaged SOD.	Zinc	51-53	superoxide dismutase 1	Homo sapiens	54-57
9509420-9	1997	We suggest that DNA cleavage is mediated in the Cu,Zn-SOD/H2O2 system via the generation of .OH by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper ions released from oxidatively damaged SOD.	Zinc	51-53	superoxide dismutase 1	Homo sapiens	151-154
9509420-9	1997	We suggest that DNA cleavage is mediated in the Cu,Zn-SOD/H2O2 system via the generation of .OH by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper ions released from oxidatively damaged SOD.	Zinc	51-53	superoxide dismutase 1	Homo sapiens	151-154
9405253-1	1997	Cyclic nucleotide phosphodiesterases (PDE), including PDE4A, contain two consensus sequences (HX3HX24-26E) which have been associated with Zn2+ binding and activation with other proteins.	Zinc	139-143	phosphodiesterase 4A	Homo sapiens	54-59
9405253-2	1997	This study shows that Zn2+ activates purified recombinant human PDE4A with an EC50 of <1 microM.	Zinc	22-26	phosphodiesterase 4A	Homo sapiens	64-69
9405253-7	1997	Titrations of PDE4A inhibition with Mg2+ and Zn2+ as activating metal ions showed that the competitive inhibitors R-Rolipram, CDP-840, RS-14203 and KF18280 are shifted at least 10-fold to lower potency in the presence of Zn2+.	Zinc	45-49	phosphodiesterase 4A	Homo sapiens	14-19
9405253-7	1997	Titrations of PDE4A inhibition with Mg2+ and Zn2+ as activating metal ions showed that the competitive inhibitors R-Rolipram, CDP-840, RS-14203 and KF18280 are shifted at least 10-fold to lower potency in the presence of Zn2+.	Zinc	221-225	phosphodiesterase 4A	Homo sapiens	14-19
9405253-9	1997	The Kd of [3H]-R-Rolipram for PDE4A was increased at least 30-fold from 3 nM (with Mg2+) by the presence of Zn2+.	Zinc	108-112	phosphodiesterase 4A	Homo sapiens	30-35
9405253-10	1997	The high affinity of Zn2+ for PDE4A indicates that this metal may play a role in the regulation of PDE4A activity.	Zinc	21-25	phosphodiesterase 4A	Homo sapiens	30-35
9405253-10	1997	The high affinity of Zn2+ for PDE4A indicates that this metal may play a role in the regulation of PDE4A activity.	Zinc	21-25	phosphodiesterase 4A	Homo sapiens	99-104
9428743-0	1997	Glyoxalase II from A. thaliana requires Zn(II) for catalytic activity.	Zinc	40-46	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	0-13
9390524-0	1997	D5 dopamine receptors enhance Zn2+-sensitive GABA(A) currents in striatal cholinergic interneurons through a PKA/PP1 cascade.	Zinc	30-34	neuropeptide Y receptor Y4	Homo sapiens	113-116
9528981-4	1998	Zn2+, Au3+, and Cd2+ depressed binding of both [125I]-IGF-I and [125I]-IGF-II.	Zinc	0-4	insulin like growth factor 1	Homo sapiens	54-59
9407319-3	1998	Cd or Zn treatment resulted in a 25-fold or 5-fold induction in growth plate MT, respectively.	Zinc	6-8	metallothionein 4	Gallus gallus	77-79
9407319-6	1998	Induction of MT in growth plate chondrocyte cell cultures was observed for media Cd concentrations of > or = 0.1 microM and Zn concentrations of > or = 100 microM.	Zinc	127-129	metallothionein 4	Gallus gallus	13-15
9407319-9	1998	Treatment of chondrocytes with Zn prior to Cd exposure resulted in a protective induction of MT.	Zinc	31-33	metallothionein 4	Gallus gallus	93-95
9405613-6	1997	One Zn2+ ion remains tightly bound in the holo-form of p53 throughout the denaturation curve.	Zinc	4-8	tumor protein p53	Homo sapiens	55-58
9391010-4	1997	Furthermore, under conditions favoring reverse operation of the Na+-Ca2+ exchanger, Zn2+ application induced a slow increase in [Zn2+]i and outward whole-cell current sensitive to benzamil-amiloride.	Zinc	84-88	solute carrier family 8 member A1	Homo sapiens	64-82
9391010-4	1997	Furthermore, under conditions favoring reverse operation of the Na+-Ca2+ exchanger, Zn2+ application induced a slow increase in [Zn2+]i and outward whole-cell current sensitive to benzamil-amiloride.	Zinc	129-133	solute carrier family 8 member A1	Homo sapiens	64-82
9543006-8	1997	One of the main contaminants found in plastic cuvets was Zn2+, which is a potent inhibitor of lambda-PPase.	Zinc	57-61	inorganic pyrophosphatase 1	Homo sapiens	101-106
9543006-9	1997	The inhibition of lambda-PPase by Zn2+ was characterized.	Zinc	34-38	inorganic pyrophosphatase 1	Homo sapiens	25-30
9325297-5	1997	Caspase activity is not affected by concentrations of Ca2+ below 100 mM, but is abolished by Zn2+ in the submicromolar range, a common characteristic of cysteine proteases.	Zinc	93-97	caspase 1	Homo sapiens	0-7
9363763-3	1997	Zn2+ enhanced the binding of Ca2+/S100A1 to twitchin kinase fragments (Kd < 50 nM) in assays using a BIAcore biosensor by reducing the S100A1 off rate.	Zinc	0-4	S100 calcium binding protein A1	Homo sapiens	34-40
11670148-9	1997	Along the investigated series, the only species reasonably mimicking both the structural arrangement and the electronic structure of the solid ZnS is Zn(10)(&mgr;(3)-S)(4)(&mgr;(2)-SPh)(12), which can be considered a molecular model of ZnS nonpolar surfaces.	Zinc	143-146	surfactant associated 3	Homo sapiens	189-192
11670148-9	1997	Along the investigated series, the only species reasonably mimicking both the structural arrangement and the electronic structure of the solid ZnS is Zn(10)(&mgr;(3)-S)(4)(&mgr;(2)-SPh)(12), which can be considered a molecular model of ZnS nonpolar surfaces.	Zinc	143-145	surfactant associated 3	Homo sapiens	189-192
9363763-1	1997	The giant myosin-associated twitchin kinase, a member of the Ca2+-regulated protein kinase superfamily, is activated by the EF-hand protein S100A1 in a Ca2+-dependent and Zn2+-enhanced manner.	Zinc	171-175	S100 calcium binding protein A1	Homo sapiens	140-146
9363763-3	1997	Zn2+ enhanced the binding of Ca2+/S100A1 to twitchin kinase fragments (Kd < 50 nM) in assays using a BIAcore biosensor by reducing the S100A1 off rate.	Zinc	0-4	S100 calcium binding protein A1	Homo sapiens	138-144
9245420-4	1997	Methods of quantifying the relative affinities of ligands for these sites in both Co(II)- and Zn(II)-substituted insulin hexamers are presented.	Zinc	94-100	insulin	Homo sapiens	113-120
15810359-3	1997	It was found that the Co(II) of CoCl2 makes an exchanging interaction with Zn(II) in Cu2Zn2SOD and thus the partial Cu2Co2SOD is formed.	Zinc	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
9339903-3	1997	The amounts of .OH radical formed in the Cu,Zn-SOD/H2O2 system reached a maximum in about 3 min.	Zinc	44-46	superoxide dismutase 1	Homo sapiens	47-50
9245399-2	1997	In addition, S100 beta also has auxiliary Zn2+ binding sites that are distinct from the Ca2+ binding sites.	Zinc	42-46	S100 calcium binding protein B	Homo sapiens	13-22
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	35-39	S100 calcium binding protein B	Homo sapiens	47-56
9221770-4	1997	The high affinity of the effect observed with NR1a-NR2A receptors was found to be attributable mostly to the slow dissociation of Zn2+ from its binding site.	Zinc	130-134	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	51-55
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	35-39	S100 calcium binding protein B	Homo sapiens	114-123
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	102-106	S100 calcium binding protein B	Homo sapiens	47-56
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	102-106	S100 calcium binding protein B	Homo sapiens	114-123
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	102-106	S100 calcium binding protein B	Homo sapiens	47-56
9245399-8	1997	Eu3+ luminescence experiments with Zn2+-loaded S100 beta show that the lifetime for Eu3+ in site I in Zn2+-loaded S100 beta is significantly different than that in the absence of Zn2+.	Zinc	102-106	S100 calcium binding protein B	Homo sapiens	114-123
9245399-11	1997	For Zn2+-S100 beta, the intersite distance is reduced to 13 +/- 0.3 A.	Zinc	4-8	S100 calcium binding protein B	Homo sapiens	9-18
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	59-62
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	82-85
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	87-91
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	64-67
9221770-7	1997	This result suggests that traces of a heavy metal (probably Zn2+) contaminate standard solutions and tonically inhibit NR1a-NR2A receptors.	Zinc	60-64	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	124-128
9256278-2	1997	In many instances, susceptible neurons are located in regions rich in Zn2+ where nerve growth factor (NGF) levels rise as a result of insult.	Zinc	70-74	nerve growth factor	Homo sapiens	81-100
9256278-2	1997	In many instances, susceptible neurons are located in regions rich in Zn2+ where nerve growth factor (NGF) levels rise as a result of insult.	Zinc	70-74	nerve growth factor	Homo sapiens	102-105
9256278-4	1997	Molecular modeling studies predict that Zn2+ binding to NGF will induce structural changes within domains of this neurotrophin that participate in the recognition of TrkA and p75NTR.	Zinc	40-44	nerve growth factor	Homo sapiens	56-59
9256278-5	1997	We demonstrate here that Zn2+ alters the conformation of NGF, rendering it unable to bind to p75NTR or TrkA receptors or to activate signal transduction pathways and biological outcomes normally induced by this protein.	Zinc	25-29	nerve growth factor	Homo sapiens	57-60
9256278-6	1997	Similar actions of Zn2+ are also observed with other members of the NGF family, suggesting a modulatory role for this metal ion in neurotrophin function.	Zinc	19-23	nerve growth factor	Homo sapiens	68-71
12223782-6	1997	From the six distinct SOD isoenzymes found in tobacco leaves, only the activities of Cu,Zn-SOD isoenzymes were affected by TMV.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	22-25
12223782-6	1997	From the six distinct SOD isoenzymes found in tobacco leaves, only the activities of Cu,Zn-SOD isoenzymes were affected by TMV.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	91-94
9228015-3	1997	In this study we investigated the effect of Zn2+ on an earlier event in the apoptotic process, the proteolysis of the "death substrate" poly(ADP-ribose) polymerase (PARP).	Zinc	44-48	poly(ADP-ribose) polymerase 1	Homo sapiens	136-163
9228015-3	1997	In this study we investigated the effect of Zn2+ on an earlier event in the apoptotic process, the proteolysis of the "death substrate" poly(ADP-ribose) polymerase (PARP).	Zinc	44-48	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
9228015-4	1997	Pretreatment of intact Molt4 leukemia cells with micromolar concentrations of Zn2+ caused an inhibition of PARP proteolysis induced by the chemotherapeutic agent etoposide.	Zinc	78-82	poly(ADP-ribose) polymerase 1	Homo sapiens	107-111
9228015-5	1997	Using a cell-free system consisting of purified bovine PARP as a substrate and an apoptotic extract or recombinant caspase-3 as the PARP protease, Zn2+ inhibited PARP proteolysis in the low micromolar range.	Zinc	147-151	poly(ADP-ribose) polymerase 1	Homo sapiens	55-59
9228015-5	1997	Using a cell-free system consisting of purified bovine PARP as a substrate and an apoptotic extract or recombinant caspase-3 as the PARP protease, Zn2+ inhibited PARP proteolysis in the low micromolar range.	Zinc	147-151	poly(ADP-ribose) polymerase 1	Homo sapiens	132-136
9228015-5	1997	Using a cell-free system consisting of purified bovine PARP as a substrate and an apoptotic extract or recombinant caspase-3 as the PARP protease, Zn2+ inhibited PARP proteolysis in the low micromolar range.	Zinc	147-151	poly(ADP-ribose) polymerase 1	Homo sapiens	132-136
9228015-7	1997	In this system, Zn2+ inhibited caspase-3 with an IC50 of 0.1 microM.	Zinc	16-20	caspase 3	Homo sapiens	31-40
9228015-8	1997	These results identify caspase-3 as a novel target of Zn2+ inhibition in apoptosis and suggest a regulatory role for Zn2+ in modulating the upstream apoptotic machinery.	Zinc	54-58	caspase 3	Homo sapiens	23-32
9202171-7	1997	The enzymatic activity responsible for proEGF nicking was inhibited by divalent heavy metal ions (Cu2+ or Zn2+) and several protease inhibitors (aprotinin, PMSF, leupeptin, soybean trypsin inhibitor), suggesting that proEGF is processed by kallikrein-like serine proteases present in the membrane preparations.	Zinc	106-110	kunitz trypsin protease inhibitor	Glycine max	181-198
9218209-10	1997	In whole-cell patch clamp recordings, both thrombin and thapsigargin evoked an inwardly rectifying Ca2+ current which developed with little or no increase in current noise, showed no reversal in the voltage range -110 to +60 mV and was blocked by 1 mM Zn2+.	Zinc	252-256	coagulation factor II, thrombin	Homo sapiens	43-51
9379906-5	1997	S. typhimurium, S. choleraesuis and S. dublin sodC mutants showed reduced lethality in a mouse model of oral infection and persisted in significantly lower numbers in livers and spleens after intraperitoneal infection, suggesting that [Cu,Zn]-SOD plays a role in pathogenicity, protecting Salmonella against oxygen radical-mediated host defences.	Zinc	239-241	superoxide dismutase 1, soluble	Mus musculus	46-50
9202323-7	1997	The binding of 125I-A beta(1-42) to alpha2M is enhanced by micromolar concentrations of Zn2+ (but not Ca2+) and is inhibited by noniodinated A beta(1-42) and A beta(1-40) but not by the reverse peptide A beta(40-1) or the cytokines interleukin 1beta or interleukin 2.	Zinc	88-92	amyloid beta precursor protein	Homo sapiens	20-26
9153200-8	1997	The HRG.Zn complex effectively competes with antithrombin for heparin, which restricts the availability of heparin to bind antithrombin and allows thrombin-mediated fibrinogenesis to proceed unimpeded.	Zinc	8-10	coagulation factor II, thrombin	Homo sapiens	49-57
9354383-6	1997	The half-dissociation pHs of Cd, Cu, and Zn from recombinant mMT-I were 3.57, 1.40, and 5.20, respectively, which are in agreement with those from native rabbit MT-I.	Zinc	41-43	metallothionein 1	Mus musculus	61-66
9354383-6	1997	The half-dissociation pHs of Cd, Cu, and Zn from recombinant mMT-I were 3.57, 1.40, and 5.20, respectively, which are in agreement with those from native rabbit MT-I.	Zinc	41-43	metallothionein 1	Mus musculus	62-66
9165671-5	1997	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 (HSP70) expression in the lungs, liver, and kidneys and significantly increased plasma levels of interleukin 6, 6-keto-PGF1 alpha, and thromboxane-B2, compared with untreated controls.	Zinc	18-22	heat shock protein 1B	Mus musculus	87-108
9153424-3	1997	Since the insulin monomer is far more susceptible than the hexamer to thermal, mechanical, and chemical degradation, insulin-dependent diabetic patients rely on pharmaceutical preparations of the Zn-insulin hexamer, which act as stable forms of the biologically active monomeric insulin.	Zinc	196-198	insulin	Homo sapiens	10-17
9153424-3	1997	Since the insulin monomer is far more susceptible than the hexamer to thermal, mechanical, and chemical degradation, insulin-dependent diabetic patients rely on pharmaceutical preparations of the Zn-insulin hexamer, which act as stable forms of the biologically active monomeric insulin.	Zinc	196-198	insulin	Homo sapiens	117-124
9153424-3	1997	Since the insulin monomer is far more susceptible than the hexamer to thermal, mechanical, and chemical degradation, insulin-dependent diabetic patients rely on pharmaceutical preparations of the Zn-insulin hexamer, which act as stable forms of the biologically active monomeric insulin.	Zinc	196-198	insulin	Homo sapiens	117-124
9153424-8	1997	Using this kinetic method, we show that the R6 conformation of Zn-insulin in the presence of Cl- ion and resorcinol is > 1.5 million-fold more stable than the T3 units of T6 and T3R3 and > 70,000-fold more stable than the R3 unit of T3R3.	Zinc	63-65	insulin	Homo sapiens	66-73
9177475-2	1997	Oxytocinase is a type II integral membrane protein of 1025 amino acid residues, consisting of an acidic intracellular region of 110 amino acids followed by a hydrophobic transmembrane segment of 22 residues and 893 extracellular residues containing the characteristic Zn2+ coordination sequence element His-Glu-Xaa-Xaa-His-(18 residues)-Glu found in gluzincins.	Zinc	268-272	leucyl and cystinyl aminopeptidase	Homo sapiens	0-11
9165671-5	1997	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 (HSP70) expression in the lungs, liver, and kidneys and significantly increased plasma levels of interleukin 6, 6-keto-PGF1 alpha, and thromboxane-B2, compared with untreated controls.	Zinc	18-22	heat shock protein 1B	Mus musculus	110-115
9165671-5	1997	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 (HSP70) expression in the lungs, liver, and kidneys and significantly increased plasma levels of interleukin 6, 6-keto-PGF1 alpha, and thromboxane-B2, compared with untreated controls.	Zinc	18-22	interleukin 6	Mus musculus	206-219
9165671-8	1997	In conclusion, the data show that the induction of HSP70 by Zn2+ attenuates the liberation of inflammatory mediators, as well as the course of hemodynamic variables due to LPS.	Zinc	60-64	heat shock protein 1B	Mus musculus	51-56
9125517-4	1997	A chemical catalytic mechanism of proteolysis consistent with the kinetic data is proposed, in which Tyr216-ArO-, in the course of being released from the active-site metal ion, deprotonates a water molecule attacking the Zn2+-activated substrate linkage, leading to a metal-coordinated tetrahedral oxyanion adduct that subsequently fragments.	Zinc	222-226	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	108-111
9063449-9	1997	In summary, we have shown that the integrity of the catalytic domain of MMP-1 and its ability to bind Zn2+ is absolutely required for complex formation with TIMP-1, which further underlines the importance of this region for proper regulation of enzymatic activity of MMP-1.	Zinc	102-106	TIMP metallopeptidase inhibitor 1	Homo sapiens	157-163
11669742-14	1997	[(eta(3)-Tp(Ph))Zn(anthranilate)] crystallizes in the monoclinic space group P2(1)/n, with a = 13.205(4) A, b = 15.643(3) A, c = 15.116(3) A, beta = 98.86(2) degrees, Z = 4, V = 3085(1) A(3), and R = 0.034.	Zinc	16-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-82
9108303-0	1997	pH-induced transition and Zn2+-binding properties of bovine prolactin.	Zinc	26-30	prolactin	Bos taurus	60-69
9025273-5	1997	Unlike the iron(III) and iron(II) ions, which are bound to two axial ligands (His 18 and Met 80), the zinc(II) ion in cytochrome c seems to be bound to only one, most probably His 18.	Zinc	102-110	cytochrome c, somatic	Homo sapiens	118-130
9124377-6	1997	Increasing the intracellular steady-state O2.- concentration by perfusion of control lungs with the Cu and Zn-containing SOD inhibitor diethyldithiocarbamate (1 mM) stimulated light emission up to fourfold, but this spontaneous chemiluminescence was also insensitive to NLA.	Zinc	107-109	superoxide dismutase 1	Homo sapiens	121-124
9003194-6	1997	High molecular weight kininogen (HK) and Zn2+ ions exert opposite effects on the inhibition of FXIa by PN-2.	Zinc	41-45	amyloid beta precursor protein	Homo sapiens	103-107
9018119-4	1997	Treatment of a stably transfected clone (AS10 cells) with Zn2+ resulted in the suppression of the experimental metastatic ability, which was accompanied with the expression of antisense S100A4 RNA and the suppression of the S100A4 expression at both the mRNA and the protein levels.	Zinc	58-62	S100 calcium binding protein A4	Mus musculus	186-192
9018119-4	1997	Treatment of a stably transfected clone (AS10 cells) with Zn2+ resulted in the suppression of the experimental metastatic ability, which was accompanied with the expression of antisense S100A4 RNA and the suppression of the S100A4 expression at both the mRNA and the protein levels.	Zinc	58-62	S100 calcium binding protein A4	Mus musculus	224-230
9003194-7	1997	HK protects FXIa from inactivation in a dose dependent and saturable manner (EC50 = 61 nM) whereas Zn2+ augments the ability of PN-2 to inhibit FXIa.	Zinc	99-103	amyloid beta precursor protein	Homo sapiens	128-132
9038914-3	1997	Investigation of Mn-SOD and Cu,Zn-SOD activities revealed that the lower SOD activity in asthmatics -CS was because of decreased Cu,Zn-SOD activity.	Zinc	31-33	superoxide dismutase 1	Homo sapiens	34-37
8995407-11	1997	These spectroscopic results are consistent with a trigonally distorted tetrahedral Co(II) geometry (C3v), an interpretation supported by the pseudotetrahedral Zn(II)(His)3(phenolate) center identified in a Zn(II)-R6 crystal structure (Smith, G. D., and Dodson, G. G. (1992) Biopolymers 32, 441-445).	Zinc	159-165	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-89
9038914-3	1997	Investigation of Mn-SOD and Cu,Zn-SOD activities revealed that the lower SOD activity in asthmatics -CS was because of decreased Cu,Zn-SOD activity.	Zinc	31-33	superoxide dismutase 1	Homo sapiens	34-37
8937427-6	1996	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 and metallothionein expression in the lungs, liver, and kidneys and increased plasma levels of TNF alpha, IL-1 beta, IL-6, and TxB2 as opposed to untreated controls.	Zinc	18-22	tumor necrosis factor	Mus musculus	204-213
8945632-4	1996	The expression of the dexamethasone-inducible transforming ras gene alone or in combination with the Zn-inducible SV40LTag mimicked the IGF-I effect inducing UCP expression and IGF-I did not induce it further.	Zinc	101-103	uncoupling protein 1	Rattus norvegicus	158-161
8973191-18	1996	The inhibitory effect by NO was reversible since, after the nitrosylated enzyme was reduced with DTT followed by incubation with ZnCl2 to allow reincorporation of Zn2+, ADH activity was increased from 20% of control values to 70%.	Zinc	163-167	aldo-keto reductase family 1 member A1	Rattus norvegicus	169-172
8975779-9	1996	Cr, Cu, Pb, and Zn moderately suppressed iNOS, which suggests that they may directly modify enzyme or cofactor activity.	Zinc	16-18	nitric oxide synthase 2, inducible	Mus musculus	41-45
8937427-6	1996	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 and metallothionein expression in the lungs, liver, and kidneys and increased plasma levels of TNF alpha, IL-1 beta, IL-6, and TxB2 as opposed to untreated controls.	Zinc	18-22	interleukin 1 beta	Mus musculus	215-224
8937427-6	1996	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 and metallothionein expression in the lungs, liver, and kidneys and increased plasma levels of TNF alpha, IL-1 beta, IL-6, and TxB2 as opposed to untreated controls.	Zinc	18-22	interleukin 6	Mus musculus	226-230
8710882-7	1996	The cleavage of lamin A by Mch2 alpha and by S/M extracts was inhibited by millimolar concentrations of Zn2+, which had a minimal effect on cleavage of poly (ADP-ribose) polymerase by CPP32 and by S/M extracts.	Zinc	104-108	caspase 3	Homo sapiens	184-189
8804590-1	1996	We performed hole-burning Stark effect experiments on cytochrome c in which the iron of the herne was either removed or replaced by Zn.	Zinc	132-134	cytochrome c, somatic	Homo sapiens	54-66
8702487-0	1996	Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.	Zinc	0-4	sphingomyelin phosphodiesterase 1	Homo sapiens	88-109
8876980-4	1996	Mercury ions bind to alpha-lactalbumin at the primary Zn2+ sites with Kass approximately (1-4) x 10(4) M-1, although the stoichiometry of the binding depends on the conformational state of the protein.	Zinc	54-58	lactalbumin alpha	Homo sapiens	21-38
8727676-2	1996	Alkaline phosphatase (ALP) is a dimeric protein with each subunit containing two Zn atoms.	Zinc	81-83	alkaline phosphatase, placental	Homo sapiens	0-20
8984476-1	1996	Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+.	Zinc	99-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
8658945-0	1996	Evaluation of plasma IL-8 (CINC) concentration during ischemia and after reperfusion in the small intestine.	Zinc	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8642478-4	1996	The chicken MT gene is inducible by dietary or injected metal ions [i.e., zinc (Zn) and copper (Cu)], bacterial lipopolysaccharide and oxidative stress.	Zinc	80-82	metallothionein 4	Gallus gallus	12-14
15067449-7	1996	Cd(2+) and Zn(2+) are predominantly bound in the labile F1(EXC) and F2(CARB) fractions.	Zinc	11-13	coagulation factor II, thrombin	Homo sapiens	59-62
8984476-1	1996	Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+.	Zinc	99-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
8928928-6	1996	MT-1 mRNA in BAT increased after 6 h, and the mRNA level after 24 h was equivalent to that in liver 6 h after injection of rats with 10 mg Zn/kg.	Zinc	139-141	metallothionein 1	Rattus norvegicus	0-4
8928928-9	1996	As with MT-1 protein, Zn in BAT increased only after 24-h cold exposure.	Zinc	22-24	metallothionein 1	Rattus norvegicus	8-12
8727676-2	1996	Alkaline phosphatase (ALP) is a dimeric protein with each subunit containing two Zn atoms.	Zinc	81-83	alkaline phosphatase, placental	Homo sapiens	22-25
8727676-3	1996	The activity of ALP in erythrocytes (E) decreases as a result of a low Zn diet, which suggests that this enzyme may be a marker of Zn status.	Zinc	71-73	alkaline phosphatase, placental	Homo sapiens	16-19
8727676-3	1996	The activity of ALP in erythrocytes (E) decreases as a result of a low Zn diet, which suggests that this enzyme may be a marker of Zn status.	Zinc	131-133	alkaline phosphatase, placental	Homo sapiens	16-19
8727676-9	1996	Our data support the hypothesis that E-ALP is a marker of Zn status in humans.	Zinc	58-60	alkaline phosphatase, placental	Homo sapiens	39-42
8727677-6	1996	The detailed analysis of the composition of the preparation suggested, that the major active component in the stimulation of IL-6 production is Zn, but for the complete effect other trace elements are also required.	Zinc	144-146	interleukin 6	Homo sapiens	125-129
8799367-9	1996	The data indicate that the maximal increase in the induction of MT by a combination of IL-6 and Dex depends on an adequate liver Zn content.	Zinc	129-131	interleukin 6	Rattus norvegicus	87-91
8833655-2	1996	Human PRL bound (65)Zn++; the Scatchard analysis was convex up, and limited by the solubility of PRL, but at least 0.7 mole Zn++ bound per mole of PRL.	Zinc	20-24	prolactin	Homo sapiens	6-9
8833655-2	1996	Human PRL bound (65)Zn++; the Scatchard analysis was convex up, and limited by the solubility of PRL, but at least 0.7 mole Zn++ bound per mole of PRL.	Zinc	124-128	prolactin	Homo sapiens	6-9
8833655-3	1996	Binding of (65)Zn++ to H27A-PRL was greatly reduced.	Zinc	15-19	prolactin	Homo sapiens	28-31
8833655-4	1996	The biological activity in an Nb2 cell assay and the circular dichroism spectrum of wild type and H27A-PRL were similar, indicating the H27A mutant folded correctly, and the binding of Zn++ to the high affinity site is not essential for biological activity.	Zinc	185-189	prolactin	Homo sapiens	103-106
8833655-5	1996	Dynamic light scattering measurements indicated 10 and 20 mu M Zn++ caused some aggregation of both wild type and H27A-PRL.	Zinc	63-67	prolactin	Homo sapiens	119-122
8833655-6	1996	Sedimentation equilibrium analysis indicated that PRL is primarily a monomer in the absence of Zn++ and that there is increasing self-association in the presence of 5 and 10 mu M Zn++.	Zinc	95-99	prolactin	Homo sapiens	50-53
8833655-8	1996	Although human PRL binds Zn++ as human GH does, it differs in that the ability to bind Zn++ and to self-associate were decoupled in PRL.	Zinc	25-29	prolactin	Homo sapiens	15-18
8833655-8	1996	Although human PRL binds Zn++ as human GH does, it differs in that the ability to bind Zn++ and to self-associate were decoupled in PRL.	Zinc	87-91	prolactin	Homo sapiens	15-18
8833655-9	1996	Human PRL must have two types of interactions with Zn++; one is binding to a site involving histidine 27, and the other is weaker interactions that induce self-association of PRL.	Zinc	51-55	prolactin	Homo sapiens	6-9
8634288-12	1996	The sequence homology between AMT1, ACE1, and MAC1 in the N-terminal 42 residues suggests that ACE1 and MAC1 will, likewise, contain N-terminal Zn modules.	Zinc	144-146	Mac1p	Saccharomyces cerevisiae S288C	46-50
8634288-12	1996	The sequence homology between AMT1, ACE1, and MAC1 in the N-terminal 42 residues suggests that ACE1 and MAC1 will, likewise, contain N-terminal Zn modules.	Zinc	144-146	Mac1p	Saccharomyces cerevisiae S288C	104-108
8605234-6	1996	The data may indicate that the two metal clusters of Zn-MT-1 and Zn-MT-2 differ in their stabilities resulting in differences in their susceptibility towards proteolytic degradation.	Zinc	53-55	metallothionein 1	Rattus norvegicus	56-60
8552392-4	1996	Using the conformational domain of p53 fused with protein A, we have shown that the p53 conformational domain possesses Zn+2-dependent, sequence-specific DNA-binding activity.	Zinc	120-124	tumor protein p53	Homo sapiens	35-38
8592145-3	1996	Previous work has demonstrated that certain metals that have been implicated as risk factors for Alzheimer"s disease (Al, Fe, and Zn) also cause substantial aggregation of A beta.	Zinc	130-132	amyloid beta precursor protein	Homo sapiens	172-178
8592145-8	1996	These results stand in significant quantitative disagreement (approximately 100-fold in zinc concentration) with one previous study that reported significant aggregation of A beta by < 1 microM Zn2+.	Zinc	197-201	amyloid beta precursor protein	Homo sapiens	173-179
8592147-8	1996	In a saturation binding assay, a value of 3.2 microM was obtained for the binding of Zn2+ to A beta but our data provided no evidence for a reported higher affinity site (107 nM).	Zinc	85-89	amyloid beta precursor protein	Homo sapiens	93-99
8552392-4	1996	Using the conformational domain of p53 fused with protein A, we have shown that the p53 conformational domain possesses Zn+2-dependent, sequence-specific DNA-binding activity.	Zinc	120-124	tumor protein p53	Homo sapiens	84-87
8852722-5	1996	UV absorbance spectra (190-300 nm) confirmed the presence of Zn in MT-1 and MT-2.	Zinc	61-63	metallothionein 1	Mus musculus	67-71
8852722-5	1996	UV absorbance spectra (190-300 nm) confirmed the presence of Zn in MT-1 and MT-2.	Zinc	61-63	metallothionein 2	Mus musculus	76-80
11666222-8	1996	The following stability sequence has been obtained: In(III) > Ga(III) >> Ni(II) > Zn(II) > Cd(II) > Pb(II) > Co(II).	Zinc	94-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	118-124
11666222-8	1996	The following stability sequence has been obtained: In(III) > Ga(III) >> Ni(II) > Zn(II) > Cd(II) > Pb(II) > Co(II).	Zinc	94-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-136
8617199-6	1996	Based on these studies, we propose a binding site model for the endogenous peptide ligand in the galanin receptor where the N-terminus of galanin hydrogen bonds with Glu271 of the receptor, Trp2 of galanin interacts with the Zn2+ sensitive pair of His264 and His267 of transmembrane domain VI, and Tyr9 of galanin interacts with Phe282 of transmembrane domain VII, while the C-terminus of galanin is pointing towards the N-terminus of th	Zinc	225-229	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	190-194
9084657-2	1996	In serum free media, MT induction was observed for Cd concentrations of 0.1 microM and greater and at Zn concentrations of 100 microM and greater.	Zinc	102-104	metallothionein 4	Gallus gallus	21-23
8649185-7	1996	The relationship between Zn and (Cd, Zn)-MT is also discussed.	Zinc	25-27	metallothionein 4	Gallus gallus	41-43
8875253-2	1996	Identification of mutations in the gene for Cu,Zn superoxide dismutase (SOD1) in a subset of ALS families made it possible to develop a transgenic mouse model of ALS and to investigate its pathogenesis.	Zinc	47-49	superoxide dismutase 1, soluble	Mus musculus	72-76
8649185-7	1996	The relationship between Zn and (Cd, Zn)-MT is also discussed.	Zinc	37-39	metallothionein 4	Gallus gallus	41-43
8720110-8	1996	Bacterial endotoxin-lipopolysaccharide (LPS) and Zn are powerful inducers of MT-I and MT-II gene expression in many adult organs, whereas these agents apparently have little effect on MT-III and MT-IV gene expression.	Zinc	49-51	metallothionein 1	Mus musculus	77-81
8720110-8	1996	Bacterial endotoxin-lipopolysaccharide (LPS) and Zn are powerful inducers of MT-I and MT-II gene expression in many adult organs, whereas these agents apparently have little effect on MT-III and MT-IV gene expression.	Zinc	49-51	metallothionein 2	Mus musculus	86-91
8938727-7	1996	Micromolar concentrations of extracellular Zn2+ non-competitively antagonized DHA inhibition of Kv1.2 channels, whereas there was little effect on DHA block of Kv3.1a channels.	Zinc	43-47	potassium voltage-gated channel subfamily A member 2	Homo sapiens	96-101
8537405-2	1995	The PDI-calreticulin complex can be dissociated by Zn(2+)-iminodiacetate-substituted Sepharose-agarose chromatography, suggesting that these interactions may be Zn2+-dependent.	Zinc	161-165	calreticulin	Homo sapiens	8-20
8560486-10	1996	The effects of Dex, Cd, and Zn, on MT-I, -II, and -III mRNAs were also examined.	Zinc	28-30	metallothionein 1	Mus musculus	35-54
8560486-11	1996	Cadmium, Zn, and Dex stimulated increases in both MT-I and MT-II mRNA, with Dex producing the greatest effect (2.0- and 3.5-fold for MT-I and -II mRNA, respectively).	Zinc	9-11	metallothionein 1	Mus musculus	50-54
8560486-11	1996	Cadmium, Zn, and Dex stimulated increases in both MT-I and MT-II mRNA, with Dex producing the greatest effect (2.0- and 3.5-fold for MT-I and -II mRNA, respectively).	Zinc	9-11	metallothionein 2	Mus musculus	59-64
8560486-11	1996	Cadmium, Zn, and Dex stimulated increases in both MT-I and MT-II mRNA, with Dex producing the greatest effect (2.0- and 3.5-fold for MT-I and -II mRNA, respectively).	Zinc	9-11	metallothionein 1	Mus musculus	133-145
8560486-13	1996	Therefore, Cd, Zn, and Dex induced MT-I and -II mRNA but not MT-III mRNA in astrocytes.	Zinc	15-17	metallothionein 1	Mus musculus	35-39
7591059-7	1995	DNAse I footprint analysis demonstrated that IdeR, in the presence of Cd2+, Co2+, Fe2+, Mn2+, Ni2+, or Zn2+, protected an approximately 30-bp region on DNA fragments carrying the tox, IRP1, or IRP2 promoter/operator sequences.	Zinc	103-107	iron-dependent repressor and activator IdeR	Mycobacterium tuberculosis H37Rv	45-49
8845382-1	1995	Xenopus laevis vitellogenin contains 2 g-atoms (g-at) of Zn and 3 g-at of Ca/dimer, transports zinc in plasma, and plays a role in its distribution within the oocyte [Montorzi et al.	Zinc	57-59	a1-a	Xenopus laevis	15-27
8605284-11	1995	Reactions of the peptide and its metal-bound forms with dioxygen or hydrogen peroxide did not produce oxygen radical species; however, oxidation of the two Sp1-3 cysteines was modulated by metal ions (Zn < Co = apo < Ni), suggesting a protective role for Zn(II) but an enhancing role for Ni(II).	Zinc	201-203	Sp1 transcription factor	Homo sapiens	156-161
8605284-12	1995	Metal binding competition between Sp1-3 and the alpha domain of human liver MT-2 (alpha-hMT2) indicates a similar affinity for Zn(II).	Zinc	127-129	Sp1 transcription factor	Homo sapiens	34-39
7578122-2	1995	Zn2+ blocks NADPH-dependent reduction of heme iron in nNOS and also blocks the calmodulin-dependent superoxide-mediated cytochrome c reductase activity exhibited by nNOS.	Zinc	0-4	cytochrome c, somatic	Homo sapiens	120-132
7592939-5	1995	PSA is 27-40% homologous to several known Zn(2+)-binding aminopeptidases including aminopeptidase N.	Zinc	42-48	aminopeptidase puromycin sensitive	Mus musculus	0-3
8962794-5	1995	On the other hand, the activity of Cu,ZnSOD was significantly reduced in the liver of pups whose dams consumed a caffeine, Zn, or caffeine plus Zn diet.	Zinc	123-125	superoxide dismutase 1	Rattus norvegicus	35-43
8703342-4	1995	SOD, D and its Cu ( II ), Zn ( II ) complexes were found to have inhibitory effect on the production of lipid peroxide in the membrane, SOD being the best among them.	Zinc	26-35	superoxide dismutase 1	Homo sapiens	0-3
8703342-4	1995	SOD, D and its Cu ( II ), Zn ( II ) complexes were found to have inhibitory effect on the production of lipid peroxide in the membrane, SOD being the best among them.	Zinc	26-35	superoxide dismutase 1	Homo sapiens	136-139
7487905-3	1995	Despite little overall homology between the primary structures of thermolysin and neprilysin, many of the amino acid residues involved in catalysis, as well as Zn2+ and substrate binding, are highly conserved.	Zinc	160-164	membrane metalloendopeptidase	Homo sapiens	82-92
7476925-4	1995	Focusing on metal ions that are present in vivo, we found that Zn(II) counteracts the inhibitory effect of Au(I) on glucocorticoid receptor function.	Zinc	63-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	107-139
7476925-6	1995	We suggest that Zn(II) preserves glucocorticoid receptor function in target tissues and maintains hormone responsiveness, even with chrysotherapy.	Zinc	16-22	nuclear receptor subfamily 3 group C member 1	Homo sapiens	33-56
7569774-6	1995	Reduced down-regulation and TNF-receptor shedding by 1,10-phenanthroline was reversed by Zn2+, indicating involvement of a Zn(2+)-dependent metalloprotease.	Zinc	89-93	tumor necrosis factor	Homo sapiens	28-31
7568234-1	1995	To explore the relationship between mitochondrial aspartate aminotransferase (mAspAT; EC 2.6.1.1) and plasma membrane fatty acid-binding protein (FABPpm) and their role in cellular fatty acid uptake, 3T3 fibroblasts were cotransfected with plasmid pMAAT2, containing a full-length mAspAT cDNA downstream of a Zn(2+)-inducible metallothionein promoter, and pFR400, which conveys methotrexate resistance.	Zinc	309-311	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	78-84
7476340-3	1995	Serum from Zn-deficient animals labeled in vitro with [125I]IGF-I displayed three peaks of tracer activity: 150 kd (IGFBP-3), 37 kd (IGFBP-2 and -1), and 8 kd (free [125I]IGF-I).	Zinc	11-13	insulin-like growth factor binding protein 2	Rattus norvegicus	133-147
7673115-12	1995	In contrast, Cu,Zn-SOD increased H2O2 accumulation from SIN-1 at low but not high concentrations of the enzyme, suggesting that high concentrations of the Cu,Zn-SOD interacted with the H2O2.	Zinc	16-18	superoxide dismutase 1	Homo sapiens	19-22
7673115-12	1995	In contrast, Cu,Zn-SOD increased H2O2 accumulation from SIN-1 at low but not high concentrations of the enzyme, suggesting that high concentrations of the Cu,Zn-SOD interacted with the H2O2.	Zinc	16-18	MAPK associated protein 1	Homo sapiens	56-61
7673115-12	1995	In contrast, Cu,Zn-SOD increased H2O2 accumulation from SIN-1 at low but not high concentrations of the enzyme, suggesting that high concentrations of the Cu,Zn-SOD interacted with the H2O2.	Zinc	16-18	superoxide dismutase 1	Homo sapiens	161-164
8588942-0	1995	Characterization of the high affinity heparin binding site of the Alzheimer"s disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc(II).	Zinc	149-157	amyloid beta precursor protein	Homo sapiens	94-119
7635354-9	1995	the rate constant reaction of 1-hydroxyethyl free radicals with Cu,Zn-SOD was measured separately by competition kinetics with the spin trapping agent alpha-(4-pyridyl 1-oxide) N-terbutylnitrone (4-POBN), after having measured the rate constant of scavenging of 1-hydroxyethyl free radicals by 4-POBN in the absence of SOD.	Zinc	67-69	superoxide dismutase 1	Homo sapiens	70-73
7658178-4	1995	Enhancement of the percentage of CD4 cells was observed after Zn therapy but had no effect on the percentage of CD8 cells and CD4/CD8 ratios.	Zinc	62-64	CD4 molecule	Homo sapiens	33-36
7651540-8	1995	The active site of hMss4 involves the Zn(2+)-binding region and a neighbouring loop.	Zinc	38-44	RAB interacting factor	Homo sapiens	19-24
7654714-3	1995	We also have presented evidence that fast protein liquid chromatography (FPLC) can be used to determine the aggregation state of insulin and that des-octapeptide(B23-30)insulin (DOI) forms Zn(2+)-coordinated hexamers that appear to be stabilized by the T --> R transformation.	Zinc	189-191	insulin	Homo sapiens	169-176
7639533-3	1995	The results show that the affinity binding of fibronectin to Co2+ is mediated exclusively via the collagen binding domain of the molecule, whereas fibronectin will bind to Zn2+, Ni2+, and Cu2+ by metal binding sites located in two, three, and four well-defined regions of fibronectin, respectively.	Zinc	172-176	fibronectin 1	Homo sapiens	147-158
7639533-3	1995	The results show that the affinity binding of fibronectin to Co2+ is mediated exclusively via the collagen binding domain of the molecule, whereas fibronectin will bind to Zn2+, Ni2+, and Cu2+ by metal binding sites located in two, three, and four well-defined regions of fibronectin, respectively.	Zinc	172-176	fibronectin 1	Homo sapiens	147-158
8562282-6	1995	Zn2+ is closely related to the thyroid and steroid hormones, insulin, parathormone, and pituitary hormones, particularly prolactin (PRL).	Zinc	0-4	insulin	Homo sapiens	61-68
8562282-6	1995	Zn2+ is closely related to the thyroid and steroid hormones, insulin, parathormone, and pituitary hormones, particularly prolactin (PRL).	Zinc	0-4	prolactin	Homo sapiens	121-130
7675218-1	1995	Available data are conflicting as regards the occurrence of Ca2+ and Zn2+ binding S100 proteins in neurons of mammalian brain.	Zinc	69-73	S100 calcium binding protein B	Homo sapiens	82-86
9981502-0	1995	Magnetism of Fe, Ni, and Zn in Nd1.85Ce0.15CuO4: Comparison of experiment and theory.	Zinc	25-27	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	31-34
7619808-0	1995	Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4.	Zinc	9-13	RAB interacting factor	Homo sapiens	103-107
7619808-6	1995	Subsequent biochemical analysis revealed that Mss4 binds 1 equiv of Zn2+, and zinc is essential for the stability of the protein.	Zinc	68-72	RAB interacting factor	Homo sapiens	46-50
7619065-7	1995	Addition of 1 microM dexamethasone (Dex) and recombinant mouse interleukin-6 (IL-6; 100 units/ml) increased MT accumulation by 8.6-fold in MT+/+ hepatocytes (at 50 microM Zn) and there was an associated parallel increase in intZn.	Zinc	171-173	interleukin 6	Mus musculus	63-76
7619065-7	1995	Addition of 1 microM dexamethasone (Dex) and recombinant mouse interleukin-6 (IL-6; 100 units/ml) increased MT accumulation by 8.6-fold in MT+/+ hepatocytes (at 50 microM Zn) and there was an associated parallel increase in intZn.	Zinc	171-173	interleukin 6	Mus musculus	78-82
7722694-6	1995	In Experiment 3, TNF-alpha dosing from GD 7-12 was associated with high maternal liver Zn and metallothionein concentrations on GD 13 and a high frequency of exencephaly on GD 18.	Zinc	87-89	tumor necrosis factor	Mus musculus	17-26
7729428-3	1995	PML contains a number of characterized motifs including a Zn2+ binding domain called the RING or C3HC4 finger.	Zinc	58-62	promyelocytic leukemia	Mus musculus	0-3
7729428-6	1995	Additional biophysical studies including CD and optical spectroscopy, show that the PML RING finger requires Zn2+ for autonomous folding and that cysteines are used in metal ligation.	Zinc	109-113	promyelocytic leukemia	Mus musculus	84-87
7729428-9	1995	Independently mutating two pairs of cysteines in each of the Zn2+ binding sites prevents PML nuclear body formation, suggesting that a fully folded RING domain is necessary for this process.	Zinc	61-65	promyelocytic leukemia	Mus musculus	89-92
7722694-9	1995	In contrast, TNF-alpha-treated litters were characterized by multiple defects, with the incidence and severity being highest in the low Zn diet group.	Zinc	136-138	tumor necrosis factor	Mus musculus	13-22
7722694-10	1995	In Experiment 5, embryos cultured in serum from TNF-alpha-treated animals exhibited a high frequency of defects; the developmental toxicity of this serum was ameliorated when it was supplemented with Zn.	Zinc	200-202	tumor necrosis factor	Mus musculus	48-57
7722694-11	1995	Thus, the developmental toxicity of TNF-alpha is due in part to its influence on Zn metabolism.	Zinc	81-83	tumor necrosis factor	Mus musculus	36-45
7891072-3	1995	The SOD activity of the apoprotein, which was initially very low, increased in a dose-dependent manner when Cu2+ and Zn2+ were added to the medium.	Zinc	117-121	superoxide dismutase 1	Homo sapiens	4-7
7778065-7	1995	Heparin and Zn2+ were found to further augment each other"s ability to stimulate the inhibition of FXIa by PN-2/A beta PP.	Zinc	12-16	amyloid beta precursor protein	Homo sapiens	107-111
7778065-8	1995	Together, these findings suggest that the interaction of Zn2+ with PN-2/A beta PP may be important for optimal inhibition of FXIa.	Zinc	57-61	amyloid beta precursor protein	Homo sapiens	67-71
7778065-0	1995	Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor.	Zinc	0-9	amyloid beta precursor protein	Homo sapiens	75-91
7778065-3	1995	In the present study, the effect of Zn2+ on the protease inhibitory properties of PN-2/A beta PP was quantitatively investigated.	Zinc	36-40	amyloid beta precursor protein	Homo sapiens	82-86
7778065-5	1995	In contrast, Zn2+ at concentrations > 1 microM increased the inhibition of FXIa by PN-2/A beta PP.	Zinc	13-17	amyloid beta precursor protein	Homo sapiens	86-90
7747530-7	1995	Zn2+ could also reduce the TNF-alpha secretion of keratinocytes stimulated by IFN-gamma or Ni2+ during 48 h. Taken together, these data indicate that zinc can directly reduce some keratinocyte activation markers frequently observed in vivo; this action may be involved in the antiinflammatory effect of Zn(2+)-associated therapies in cutaneous inflammatory reactions.	Zinc	0-4	tumor necrosis factor	Homo sapiens	27-36
7532789-5	1995	In a double mutant with histidine residues substituted at the top of transmembrane segments V and VI, respectively, Zn2+ inhibits binding of radiolabelled agonist peptide and efficiently blocks phosphoinositol turnover induced by substance P.	Zinc	116-120	tachykinin precursor 1	Homo sapiens	230-241
7862134-4	1995	Thus, the binuclear Zn clusters of GAL4, the helix-loop-helix/basic domains of USF, and the rel domain of NF-kappa B all participated in cooperative nucleosome binding, illustrating that this effect is not restricted to a particular DNA-binding domain.	Zinc	20-22	nuclear factor kappa B subunit 1	Homo sapiens	106-116
7829507-8	1995	Zn2+, Cu2+, Mn2+, Mg2+, Co2+, Cd2+, and Ba2+ were tested for their ability to modulate Ca2+ binding and protease sensitivity of TSP1.	Zinc	0-4	thrombospondin 1	Homo sapiens	128-132
8548200-4	1995	The effect of BDP was greatly dependent on the presence of Zn++ ions in the preparation, since the augmenting effect was abolished if BDP did not contain zinc.	Zinc	59-63	AT-rich interaction domain 3B	Homo sapiens	14-17
8548200-4	1995	The effect of BDP was greatly dependent on the presence of Zn++ ions in the preparation, since the augmenting effect was abolished if BDP did not contain zinc.	Zinc	59-63	AT-rich interaction domain 3B	Homo sapiens	134-137
7890047-4	1995	Our finding also reveals that Zn2+ is a necessary component of NF-kappa B for its DNA binding activity and that gold ion can efficiently block NF-kappa B-DNA binding, presumably through oxidation of the cysteins associated with zinc.	Zinc	30-34	nuclear factor kappa B subunit 1	Homo sapiens	63-73
7890047-4	1995	Our finding also reveals that Zn2+ is a necessary component of NF-kappa B for its DNA binding activity and that gold ion can efficiently block NF-kappa B-DNA binding, presumably through oxidation of the cysteins associated with zinc.	Zinc	30-34	nuclear factor kappa B subunit 1	Homo sapiens	143-153
7850808-5	1995	Expression of mutant p21ras in these cells, induced by Zn2+, resulted in an approximate 30-fold increase in the IGF-1 production rate, reaching a level exceeding that of human embryo fibroblasts.	Zinc	55-59	insulin like growth factor 1	Homo sapiens	112-117
7747530-7	1995	Zn2+ could also reduce the TNF-alpha secretion of keratinocytes stimulated by IFN-gamma or Ni2+ during 48 h. Taken together, these data indicate that zinc can directly reduce some keratinocyte activation markers frequently observed in vivo; this action may be involved in the antiinflammatory effect of Zn(2+)-associated therapies in cutaneous inflammatory reactions.	Zinc	0-4	interferon gamma	Homo sapiens	78-87
7890805-3	1994	The signal is likely independent of protein kinase C, but depends on tyrosine kinase and other kinase activities and is mediated by c-Ha-Ras since the presence of dominant-negative mutants of Ras and Raf abrogates the induction of Egr-1 expression by Zn2+.	Zinc	251-255	zinc fingers and homeoboxes 2	Mus musculus	200-203
8705286-6	1995	It was also noticed, that in the pt rabbit the ratio CAT/Cu, Zn-SOD was lower by 20% in the brain hemispheres and by 13% in the cerebellum and the ratio POX/Cu, Zn-SOD was lower by 31.8% in the brain stem.	Zinc	61-63	catalase	Oryctolagus cuniculus	53-56
7749260-17	1995	Zn deficiency is known to decrease interleukin 2 production by helper T lymphocytes, and abnormalities in T-lymphocyte subpopulations have been observed in Zn-deficient humans.	Zinc	0-2	interleukin 2	Homo sapiens	35-48
7923440-5	1994	Increasing the concentration of Zn in the bovine serum albumin (BSA)-containing culture medium up to 50 microM significantly increased MT-I levels by up to 3.5-fold in neurons and 2.5-fold in astrocytes.	Zinc	32-34	metallothionein 1	Rattus norvegicus	135-139
7923440-7	1994	In general, the combination of Zn and Cu further increased MT-I levels.	Zinc	31-33	metallothionein 1	Rattus norvegicus	59-63
7753753-8	1995	Cd2+ and Zn2+ were potent inhibitors of both binding sites, Cd2+ particularly of rem2 binding and Zn2+ preferably of rem1 binding.	Zinc	9-13	RRAD and GEM like GTPase 2	Rattus norvegicus	81-85
7811703-3	1994	Our results show that the presence of Zn2+ ions at physiological concentrations, directly reduced or blocked accessibility of epitopes on pure wild-type p53, an effect which was reversed by chelating agents.	Zinc	38-42	tumor protein p53	Homo sapiens	153-156
7811703-5	1994	Analytical sucrose density gradient ultracentrifugation studies also confirmed that Zn(2+)-induced conformational changes partially affected the pattern of p53 oligomerisation.	Zinc	84-90	tumor protein p53	Homo sapiens	156-159
7890805-5	1994	Transient assays also demonstrated that Zn2+ or activated Ras expression stimulate the activity of a 950 bp Egr-1 promoter-reporter gene construct and this is abrogated in the presence of mutant Ras and Raf.	Zinc	40-44	zinc fingers and homeoboxes 2	Mus musculus	203-206
7980447-3	1994	Culture with combinations of Zn, dexamethasone and interleukin-6, increased intracellular MT by 24-fold, Zn 3-fold, and Zinquin fluorescence by approx.	Zinc	105-107	interleukin 6	Rattus norvegicus	51-64
7957684-3	1994	Western blot analysis using monoclonal antibody against human HSP72 showed that the maximum induction level after the addition of 80 microM ZnSO4 was almost one-third of that by heat shock treatment at 43 degrees C for 2 h. The growth rate increased slightly when Zn2+ was present during cultivation.	Zinc	264-268	heat shock protein family A (Hsp70) member 1A	Homo sapiens	62-67
7696531-2	1994	The complexes formed with zinc(II) and the ligands rac-DMSA and meso-DMSA have been postulated from potentiometric titrations of solutions containing varying ratios of zinc:ligand.	Zinc	26-34	Rac family small GTPase 2	Homo sapiens	51-54
24226385-4	1994	Additionally, tandem mass spectra from the zinc-attached ions for angiotensin I show abundant [b 6 + Zn](2+) and [b 9 + Zn](2+) products, providing evidence that both His(6) and His(9) are involved in zinc coordination.	Zinc	101-103	angiotensinogen	Homo sapiens	66-79
24226385-4	1994	Additionally, tandem mass spectra from the zinc-attached ions for angiotensin I show abundant [b 6 + Zn](2+) and [b 9 + Zn](2+) products, providing evidence that both His(6) and His(9) are involved in zinc coordination.	Zinc	120-122	angiotensinogen	Homo sapiens	66-79
8090778-2	1994	By site-directed mutagenesis, we have demonstrated that invariant residues Asp-261 and Glu-262 of the nucleic acid-binding TFIIS Zn ribbon are critical for stimulation of both elongation and RNA cleavage activities of RNA polymerase II.	Zinc	129-131	transcription elongation factor A2	Homo sapiens	123-128
7850252-1	1994	Copper (Cu) and zinc (Zn)-binding superoxide dismutase (Cu,Zn-SOD) is synthesized always in a form of holo-protein in the liver of LEC rats, a genetically disordered mutant strain in Cu metabolism which accumulates Cu in a form bound to metallothionein (MT).	Zinc	22-24	superoxide dismutase 1	Rattus norvegicus	56-65
8090778-5	1994	The RNA polymerase II itself may contain a Zn ribbon, in as much as the polymerase"s 15-kDa subunit contains a sequence that aligns well with the TFIIS Zn ribbon sequence, including a similarly placed pair of acidic residues.	Zinc	152-154	transcription elongation factor A2	Homo sapiens	146-151
8070580-6	1994	The Zn(2+)-deficient enzyme catalyzes Ap3A synthesis in the absence of exogenous ADP due to ATPase activity of Zn(2+)-deprived TrpRS.	Zinc	4-10	tryptophanyl-tRNA synthetase 1	Homo sapiens	127-132
8077192-1	1994	cGMP-binding cGMP-specific phosphodiesterase (cG-BPDE) binds tightly to a Zn(2+)-chelate column (Francis, S. H., and Corbin, J. D. (1988) Methods Enzymol.	Zinc	74-80	phosphodiesterase 5A	Homo sapiens	0-44
8077192-1	1994	cGMP-binding cGMP-specific phosphodiesterase (cG-BPDE) binds tightly to a Zn(2+)-chelate column (Francis, S. H., and Corbin, J. D. (1988) Methods Enzymol.	Zinc	74-80	phosphodiesterase 5A	Homo sapiens	46-53
8077192-3	1994	Using three different approaches, Zn2+ is now shown to bind to cG-BPDE, and the Kd is determined to be approximately 0.5 microM, with a binding stoichiometry of approximately 3 mol of Zn2+/mol of monomer.	Zinc	34-38	phosphodiesterase 5A	Homo sapiens	63-70
8077192-3	1994	Using three different approaches, Zn2+ is now shown to bind to cG-BPDE, and the Kd is determined to be approximately 0.5 microM, with a binding stoichiometry of approximately 3 mol of Zn2+/mol of monomer.	Zinc	184-188	phosphodiesterase 5A	Homo sapiens	63-70
8077192-5	1994	The Zn2+ binding to cG-BPDE is not diminished by, nor is catalysis supported by, relatively high concentrations of Cu2+, Cd2+, Ca2+, or Fe2+.	Zinc	4-8	phosphodiesterase 5A	Homo sapiens	20-27
8073054-2	1994	In the present study, the influence of Zn status on the response to continuous low-dose IL-1 beta administration was evaluated.	Zinc	39-41	interleukin 1 beta	Rattus norvegicus	88-97
8071312-7	1994	Induced expression of N17Ras by the addition of Zn2+ clearly prevented dissociation of the cells by SF/HGF.	Zinc	48-52	hepatocyte growth factor	Canis lupus familiaris	100-106
8073054-9	1994	AZn IL-1 beta-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated.	Zinc	1-3	interleukin 1 beta	Rattus norvegicus	4-13
8073054-11	1994	These data show that Zn status can influence the response to low-dose IL-1 beta; this influence of Zn should be considered when IL-1 beta is given therapeutically.	Zinc	21-23	interleukin 1 beta	Rattus norvegicus	70-79
8070580-6	1994	The Zn(2+)-deficient enzyme catalyzes Ap3A synthesis in the absence of exogenous ADP due to ATPase activity of Zn(2+)-deprived TrpRS.	Zinc	111-117	tryptophanyl-tRNA synthetase 1	Homo sapiens	127-132
8070580-7	1994	The inability of mammalian TrpRS to synthesize Ap4A, might be considered as a molecular tool preventing the removal of Zn2+ due to chelation by Ap4A and therefore preserving the enzyme activity.	Zinc	119-123	tryptophanyl-tRNA synthetase 1	Homo sapiens	27-32
7749371-12	1994	These data therefore suggest that physiological concentrations of P(i) and Zn(II) may be sufficient for a low-level turnover of the contact system in plasma which in turn may be responsible for the background levels of cleaved HK and BK found in normal plasma.	Zinc	75-81	kininogen 1	Homo sapiens	234-236
8055938-10	1994	Zn2+ binding to p53 protect sulfhydryl groups from oxidation.	Zinc	0-4	tumor protein p53	Homo sapiens	16-19
8041712-3	1994	We further demonstrated that Zn(2+)-inducible cyclin A expression was sufficient to cause apoptosis.	Zinc	29-35	cyclin A2	Homo sapiens	46-54
8037675-10	1994	The binding constant for Zn2+ is increased to 125% in the case of proAlb Varese, decreased to 50-60% for proAlb Christchurch and Alb Redhill but is normal for proAlb Blenheim, Alb Blenheim and Arg-Alb.	Zinc	25-29	albumin	Homo sapiens	69-72
8061228-2	1994	The binding of Zn(II) to human serum albumin (HSA) and bovine serum albumin (BSA) was intensively studied by equilibrium dialysis.	Zinc	15-21	albumin	Homo sapiens	31-45
8061228-2	1994	The binding of Zn(II) to human serum albumin (HSA) and bovine serum albumin (BSA) was intensively studied by equilibrium dialysis.	Zinc	15-21	albumin	Homo sapiens	62-81
8037675-10	1994	The binding constant for Zn2+ is increased to 125% in the case of proAlb Varese, decreased to 50-60% for proAlb Christchurch and Alb Redhill but is normal for proAlb Blenheim, Alb Blenheim and Arg-Alb.	Zinc	25-29	albumin	Homo sapiens	108-111
8037675-10	1994	The binding constant for Zn2+ is increased to 125% in the case of proAlb Varese, decreased to 50-60% for proAlb Christchurch and Alb Redhill but is normal for proAlb Blenheim, Alb Blenheim and Arg-Alb.	Zinc	25-29	albumin	Homo sapiens	108-111
7932044-0	1994	Induction of the conversion of xanthine dehydrogenase to oxidase in rabbit liver by Cu2+,Zn2+ and selenium ions.	Zinc	89-93	xanthine dehydrogenase/oxidase	Oryctolagus cuniculus	31-53
7965011-10	1994	GCl(V) was blocked by bath application of 100 microM zinc (Zn2+), but not when 1-6 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or bis-(o-aminophenoxy)-N,N,N",N"-tetraacetic acid (BAPTA) were present in the electrode solution.	Zinc	59-63	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	0-3
8209258-0	1994	Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.	Zinc	58-60	superoxide dismutase 1	Homo sapiens	61-81
8194582-1	1994	The purpose of the present study was to determine the relationship between concentration of Zn, Cu and Fe, and the catalase, glutathione peroxidase and superoxide dismutase activities in the heart and liver of newborn rats whose dams were fed a diet supplemented with caffeine.	Zinc	92-94	catalase	Rattus norvegicus	115-123
7932044-1	1994	Effects of Cu2+,Zn2+,Fe2+ and selenium ions on the conversion of xanthine dehydrogenase to oxidase in rabbit liver were examined.	Zinc	16-20	xanthine dehydrogenase/oxidase	Oryctolagus cuniculus	65-87
7932044-3	1994	Cu2+ (2-10 microM), Zn2+ (5-30 microM) and selenium ions (5-100 microM) brought about the conversion of xanthine dehydrogenase to oxidase in a dose-dependent manner.	Zinc	20-24	xanthine dehydrogenase/oxidase	Oryctolagus cuniculus	104-126
7932044-6	1994	These results suggest that Cu2+,Zn2+ and selenium ions have the potential to modulate the conversion of xanthine dehydrogenase to oxidase in rabbit liver.	Zinc	32-36	xanthine dehydrogenase/oxidase	Oryctolagus cuniculus	104-126
8015375-4	1994	GluR3 but not GluR1 receptors produced currents that were enhanced by low concentrations of Zn2+.	Zinc	92-96	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	0-5
8163520-2	1994	We studied the binding of Zn2+ to a synthetic peptide representing residues 1-40 (A beta 1-40), as well as other domains of A beta.	Zinc	26-30	amyloid beta precursor protein	Homo sapiens	82-88
8163520-7	1994	Zinc binding also increased A beta resistance to tryptic cleavage at the secretase site, indicating that a small (<3 microM) increase in brain Zn2+ concentration could significantly alter A beta metabolism.	Zinc	146-150	amyloid beta precursor protein	Homo sapiens	28-34
8163520-7	1994	Zinc binding also increased A beta resistance to tryptic cleavage at the secretase site, indicating that a small (<3 microM) increase in brain Zn2+ concentration could significantly alter A beta metabolism.	Zinc	146-150	amyloid beta precursor protein	Homo sapiens	191-197
7945790-1	1994	alpha-Lactalbumin possesses multiple Zn2+ binding sites, with the strongest site having an affinity constant of 5 x 10(5) M-1 [Permyakov et al.	Zinc	37-41	lactalbumin alpha	Homo sapiens	0-17
7945790-10	1994	Fluorescence energy transfer measurements between Tb3+ in the strong calcium site to Co2+ in the strong Zn2+ site gave a distance in the range of 14-18 A, which was in excellent agreement with recent crystallographic data for human alpha-lactalbumin [Ren et al.	Zinc	104-108	lactalbumin alpha	Homo sapiens	232-249
8200074-4	1994	Treatment of 14-day embryos with zinc(II) resulted in a 3- to 5-fold increase in steady-state levels of metallothionein mRNA in liver.	Zinc	33-41	metallothionein 4	Gallus gallus	104-119
8200074-5	1994	Pre-treatment of 14-day embryos with chromium(VI) inhibited the zinc(II)-induced increase in steady-state levels of metallothionein mRNA and protein in liver by 30-50%.	Zinc	64-72	metallothionein 4	Gallus gallus	116-131
8182343-4	1994	Pretreatments with a CD18-directed monoclonal antibody, WT-3 (1 mg/kg), significantly attenuated the increase in number of adherent and migrated neutrophils, the increase in luminol-dependent chemiluminescence, and the venular macromolecular leakage after the application of CINC/gro.	Zinc	275-279	integrin subunit beta 2	Rattus norvegicus	21-25
8157637-3	1994	Seven cysteinyl residues and a single histidyl residue in the LIM2 sequence, CX2CX17HX2CX2CX2CX17CX2C, comprise the conserved residues in the LIM consensus that are potential Zn(II) ligands.	Zinc	175-177	lens intrinsic membrane protein 2	Homo sapiens	62-66
8157637-4	1994	Two Zn(II) binding sites exhibiting tetrathiolate (S4) and S3N1 Zn(II) coordination are displayed by LIM2 (Kosa, J. L., Michelsen, J. W., Louis, H. A., Olsen, J. I., Davis, D. R., Beckerle, M. C., and Winge, D. R. (1994) Biochemistry 33, 468-477).	Zinc	4-10	lens intrinsic membrane protein 2	Homo sapiens	101-105
8157637-4	1994	Two Zn(II) binding sites exhibiting tetrathiolate (S4) and S3N1 Zn(II) coordination are displayed by LIM2 (Kosa, J. L., Michelsen, J. W., Louis, H. A., Olsen, J. I., Davis, D. R., Beckerle, M. C., and Winge, D. R. (1994) Biochemistry 33, 468-477).	Zinc	64-70	lens intrinsic membrane protein 2	Homo sapiens	101-105
8168507-7	1994	Using metal affinity chromatography, we have established that pure p53 binds the immobilised divalent ions Zn2+, Ni2+ and Co2+ with high affinity.	Zinc	107-111	tumor protein p53	Homo sapiens	67-70
8015375-11	1994	The major change in the kainate I-V relationship for GluR3 produced by Zn2+ may begin to explain the differential action of Zn2+ on two otherwise similar glutamate receptors.	Zinc	71-75	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	53-58
8015375-11	1994	The major change in the kainate I-V relationship for GluR3 produced by Zn2+ may begin to explain the differential action of Zn2+ on two otherwise similar glutamate receptors.	Zinc	124-128	glutamate receptor, ionotropic, AMPA 3 L homeolog	Xenopus laevis	53-58
7511119-5	1994	alpha 2M was purified to apparent homogeneity by PEG precipitation, DEAE-Toyopearl 650M, Bio-Gel A-5m and Zn(2+)-affinity chromatography.	Zinc	106-108	alpha-2-macroglobulin	Bos taurus	0-8
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc	19-23	interferon gamma	Homo sapiens	73-82
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc	19-23	interleukin 1 beta	Homo sapiens	84-93
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc	19-23	interleukin 6	Homo sapiens	95-99
8186320-3	1994	In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner.	Zinc	19-23	tumor necrosis factor	Homo sapiens	101-110
8299997-2	1994	Mildly Zn deficient rats showed very high degrees of CCl4-induced hepatic cell membrane injury as assessed by serum sorbitol dehydrogenase activities.	Zinc	7-9	C-C motif chemokine ligand 4	Rattus norvegicus	53-57
8299997-4	1994	An acute phase response, elicited by leg inflammation, strongly protected rats consuming adequate Zn, either ad libitum or pair-fed, against the CCl4-induced rise in sorbitol dehydrogenase.	Zinc	98-100	C-C motif chemokine ligand 4	Rattus norvegicus	145-149
8181907-2	1994	Administration of recombinant human IL-6 or TNF to rats caused the acute phase responses including rapid decreases in plasma zinc (Zn), and increases in plasma copper (Cu) and ceruloplasmin.	Zinc	131-133	interleukin 6	Homo sapiens	36-40
8181907-2	1994	Administration of recombinant human IL-6 or TNF to rats caused the acute phase responses including rapid decreases in plasma zinc (Zn), and increases in plasma copper (Cu) and ceruloplasmin.	Zinc	131-133	tumor necrosis factor	Homo sapiens	44-47
8241506-7	1993	Platelet activation with Zn+2 also enhanced GPIIb and GPIIIa recovery on fibrinogen-coated surfaces over that observed with unstimulated platelets, but GPIIb and IIIa retention was EDTA sensitive.	Zinc	25-29	integrin subunit beta 3	Homo sapiens	54-60
8253196-1	1993	Bovine tryptophanyl-tRNA synthetase (EC 6.1.1.2) deprived of Zn2+ by chelation with the phosphonate analog of Ap4A hydrolyzed ATP(GTP) to ADP(GDP) although its ability to form tryptophanyl adenylate was impaired.	Zinc	61-65	tryptophanyl-tRNA synthetase 1	Homo sapiens	7-35
8257435-2	1993	Although the native Zn(II)-containing and the Co(II)-reconstituted enzymes have closely similar Michaelis constants and maximal velocities, the kinetics for both the inactivation by OP and the reconstitution of the apoenzyme with the metal ions differs considerably.	Zinc	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
8257435-6	1993	Both the native and the Co(II)-reconstituted enzymes are inhibited by excess of Zn(II), but not by Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
8257435-6	1993	Both the native and the Co(II)-reconstituted enzymes are inhibited by excess of Zn(II), but not by Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
8241506-7	1993	Platelet activation with Zn+2 also enhanced GPIIb and GPIIIa recovery on fibrinogen-coated surfaces over that observed with unstimulated platelets, but GPIIb and IIIa retention was EDTA sensitive.	Zinc	25-29	fibrinogen beta chain	Homo sapiens	73-83
8241506-8	1993	This correlated with the EDTA-reversible nature of Zn+2-activated platelet adhesion to fibrinogen-coated surfaces.	Zinc	51-55	fibrinogen beta chain	Homo sapiens	87-97
8366079-1	1993	It has been proposed that the binding of Zn2+ to alpha-lactalbumin switches the conformation to one akin to a state intermediate in the folding of the protein.	Zinc	41-45	lactalbumin alpha	Homo sapiens	49-66
8399164-4	1993	Complete 1H and 15N NMR resonance assignment of a 50-residue TFIIS peptide-Zn2+ complex is obtained.	Zinc	75-79	transcription elongation factor A2	Homo sapiens	61-66
8399164-8	1993	The role of the TFIIS Zn ribbon in the control of eukaryotic transcriptional elongation is discussed.	Zinc	22-24	transcription elongation factor A2	Homo sapiens	16-21
8366079-3	1993	The Zn2+ ion binds specifically in the "cleft" of alpha-lactalbumin (the region which forms the active site of the homologous protein lysozyme).	Zinc	4-8	lactalbumin alpha	Homo sapiens	50-67
8240277-4	1993	The C5a-stimulated influx of 45Ca2+ into U937 cells is inhibited by a series of metal ions (Zn2+ > Co2+ > Mn2+ > Sr2+ approximately equal to Ni2+ > La3+).	Zinc	92-96	complement C5a receptor 1	Homo sapiens	4-7
8142006-4	1993	In the presence of alpha-lactalbumin (i.e., lactose synthase), the Mn(II)-activation is biphasic and the initial phase is inhibited by increasing concentrations of Zn(II).	Zinc	164-166	lactalbumin alpha	Homo sapiens	19-36
8142006-6	1993	The results suggest that Zn(II) binding to alpha-lactalbumin effects lactose synthase.	Zinc	25-31	lactalbumin alpha	Homo sapiens	43-60
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	lactalbumin alpha	Homo sapiens	148-165
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	lactalbumin alpha	Homo sapiens	220-237
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	lactalbumin alpha	Homo sapiens	220-237
8366079-3	1993	The Zn2+ ion binds specifically in the "cleft" of alpha-lactalbumin (the region which forms the active site of the homologous protein lysozyme).	Zinc	4-8	lysozyme	Homo sapiens	134-142
8366079-2	1993	However, the high resolution x-ray crystal structure of human alpha-lactalbumin-Zn2+ complex at 1.7-A resolution (pH 7.6) does not reveal any significant change in conformation from the native state.	Zinc	80-84	lactalbumin alpha	Homo sapiens	62-79
8313237-6	1993	Although Zn plays a structural role in the enzyme Cu, Zn superoxide dismutase, the activity of this enzyme is not decreased in Zn deficiency and its activity is usually depressed at high Zn intakes.	Zinc	9-11	superoxide dismutase 1	Homo sapiens	50-77
8360253-12	1993	A rationale for co-packaging these components within the alpha-granules is that Zn(II) inhibits factor XIII activity and thereby prevents the premature cross-linking of the concentrated fibrinogen prior to platelet activation and secretion.	Zinc	80-86	fibrinogen beta chain	Homo sapiens	186-196
8292750-3	1993	Hepatic MT, which is induced by Zn(II), has been proposed to protect against CCl4-induced cellular damage by scavenging the free radical metabolites formed.	Zinc	32-34	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
8292750-4	1993	CCl4-induced hepatotoxicity was significantly suppressed in male Sprague-Dawley rats pretreated with a single dose of 5 mg/kg Zn(II) or Cr(III) according to standard serum assays for liver-specific enzymes, and hepatic MT was elevated after pretreatment with either Zn(II) or Cr(III).	Zinc	126-128	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
8292750-4	1993	CCl4-induced hepatotoxicity was significantly suppressed in male Sprague-Dawley rats pretreated with a single dose of 5 mg/kg Zn(II) or Cr(III) according to standard serum assays for liver-specific enzymes, and hepatic MT was elevated after pretreatment with either Zn(II) or Cr(III).	Zinc	266-268	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
8360772-10	1993	There was no accumulation of metallothionein with interleukin-1 beta, tumor necrosis factor alpha or interferon gamma (1 x 10(5) U/L) alone, but interleukin-1 beta and tumor necrosis factor alpha enhanced the response obtained with Zn+dexamethasone with and without interleukin-6.	Zinc	232-234	interleukin 1 beta	Rattus norvegicus	145-195
8344894-0	1993	A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer"s disease.	Zinc	8-16	amyloid beta precursor protein	Homo sapiens	68-93
8360772-5	1993	Interleukin-6 (1 x 10(5) U/L) alone did not induce metallothionein but increased it 35-65% with Zn+dexamethasone.	Zinc	96-98	interleukin 6	Rattus norvegicus	0-13
8270282-1	1993	Pseudomonas strain MR1 isolated from the coastal waters of Bay of Bengal was found to resist Hg, As, Cd, Cu, Zn and Pb.	Zinc	109-111	major histocompatibility complex, class I-related	Homo sapiens	19-22
8102964-6	1993	The importance of vitamins A and D and the minerals Zn and Ca has been considered in the regulation of insulin activity and glucose transport in these cells.	Zinc	52-54	insulin	Homo sapiens	103-110
8390691-2	1993	Previous work has shown that Zn deficiency reduces the activity of angiotensin-converting enzyme (ACE), a Zn-dependent enzyme, in the testes of prepubertal rats.	Zinc	29-31	angiotensin I converting enzyme	Rattus norvegicus	98-101
8390691-2	1993	Previous work has shown that Zn deficiency reduces the activity of angiotensin-converting enzyme (ACE), a Zn-dependent enzyme, in the testes of prepubertal rats.	Zinc	106-108	angiotensin I converting enzyme	Rattus norvegicus	98-101
8390691-9	1993	After 4 weeks, ACE activity in testes of the Zn-deficient rats was reduced by 74% compared to that in the ad libitum-fed controls.	Zinc	45-47	angiotensin I converting enzyme	Rattus norvegicus	15-18
8390691-12	1993	Refeeding Zn-deficient rats a Zn-adequate diet for 2 weeks restored ACE protein concentrations and ACE activity to values not significantly different from those in pair-fed controls.	Zinc	10-12	angiotensin I converting enzyme	Rattus norvegicus	68-71
8390691-12	1993	Refeeding Zn-deficient rats a Zn-adequate diet for 2 weeks restored ACE protein concentrations and ACE activity to values not significantly different from those in pair-fed controls.	Zinc	10-12	angiotensin I converting enzyme	Rattus norvegicus	99-102
8390691-12	1993	Refeeding Zn-deficient rats a Zn-adequate diet for 2 weeks restored ACE protein concentrations and ACE activity to values not significantly different from those in pair-fed controls.	Zinc	30-32	angiotensin I converting enzyme	Rattus norvegicus	68-71
8390691-12	1993	Refeeding Zn-deficient rats a Zn-adequate diet for 2 weeks restored ACE protein concentrations and ACE activity to values not significantly different from those in pair-fed controls.	Zinc	30-32	angiotensin I converting enzyme	Rattus norvegicus	99-102
8390691-13	1993	Soluble ACE, but not particulate ACE, of the epididymis was significantly reduced by Zn deficiency.	Zinc	85-87	angiotensin I converting enzyme	Rattus norvegicus	8-11
8390691-14	1993	Because the ACE activity of testes has been found primarily in the germinal cells, and soluble ACE in the epididymis is derived from the testes, these findings suggest that the effects of Zn deficiency on testicular and epididymal ACE is caused by an impairment of spermatid development.	Zinc	188-190	angiotensin I converting enzyme	Rattus norvegicus	12-15
8390691-14	1993	Because the ACE activity of testes has been found primarily in the germinal cells, and soluble ACE in the epididymis is derived from the testes, these findings suggest that the effects of Zn deficiency on testicular and epididymal ACE is caused by an impairment of spermatid development.	Zinc	188-190	angiotensin I converting enzyme	Rattus norvegicus	95-98
8390691-14	1993	Because the ACE activity of testes has been found primarily in the germinal cells, and soluble ACE in the epididymis is derived from the testes, these findings suggest that the effects of Zn deficiency on testicular and epididymal ACE is caused by an impairment of spermatid development.	Zinc	188-190	angiotensin I converting enzyme	Rattus norvegicus	95-98
8512561-0	1993	Human liver calreticulin: characterization and Zn(2+)-dependent interaction with phenyl-sepharose.	Zinc	47-53	calreticulin	Homo sapiens	12-24
8512561-4	1993	We also show that calreticulin and calsequestrin bind Zn2+ in 65Zn2+ overlay.	Zinc	54-58	calreticulin	Homo sapiens	18-30
8512561-5	1993	In addition we have discovered that calreticulin exhibits a Zn(2+)-dependent interaction with hydrophobic matrix of phenyl-Sepharose that can be utilized in the purification of the protein.	Zinc	60-66	calreticulin	Homo sapiens	36-48
8322369-12	1993	Nifedipine (500 nM), a potent voltage-gated calcium channel blocker, and zinc (Zn; 100-fold molar excess) each significantly reduced (approximately 50% in 2 h) Cd accumulation by blastocysts, whereas N-ethylymaleimide (NEM; 20 microM) increased it.	Zinc	79-81	inversion, Chr 2, Harwell 2, proximal	Mus musculus	152-158
8482390-6	1993	The activity of aminopeptidase yscXVI is abolished by chelating agents and restored by Zn2+, Mn2+ and Co2+ ions.	Zinc	87-91	aminopeptidase	Saccharomyces cerevisiae S288C	16-30
8389399-6	1993	The lower concentration of Zn partially and the higher concentration totally prevented the tumor necrosis factor-induced increase in albumin transfer.	Zinc	27-29	tumor necrosis factor	Homo sapiens	91-112
8389399-7	1993	The increase in cytosolic release of [3H]adenine (marker of cell injury) induced by tumor necrosis factor was prevented by added Zn.	Zinc	129-131	tumor necrosis factor	Homo sapiens	84-105
8389399-10	1993	Tumor necrosis factor treatment caused a decrease in cellular Zn concentration, which was prevented when the culture media were enriched with Zn.	Zinc	62-64	tumor necrosis factor	Homo sapiens	0-21
8389399-10	1993	Tumor necrosis factor treatment caused a decrease in cellular Zn concentration, which was prevented when the culture media were enriched with Zn.	Zinc	142-144	tumor necrosis factor	Homo sapiens	0-21
8389399-11	1993	These data suggest that an important relationship exists between Zn status and tumor necrosis factor-induced endothelial cell dysfunction.	Zinc	65-67	tumor necrosis factor	Homo sapiens	79-100
8455597-2	1993	In addition to cobalt, the cot2 mutants were found to tolerate increased levels of the divalent cations Zn2+, Mn2+, and Ni2+ as well.	Zinc	104-108	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	27-31
8473303-6	1993	The Zn(2+)-mediated fibrin binding of Sc-uPA is reversible, specific, and saturable.	Zinc	4-6	plasminogen activator, urokinase	Homo sapiens	41-44
8473303-9	1993	The present study conclusively shows that Sc-uPA possesses a latent affinity for fibrin that is expressed in the presence of Zn2+.	Zinc	125-129	plasminogen activator, urokinase	Homo sapiens	45-48
8473303-10	1993	These findings raise the possibility that Zn2+ plays a regulatory role in uPA-mediated fibrinolysis by promoting effective localization of Sc-uPA at the clot surface.	Zinc	42-46	plasminogen activator, urokinase	Homo sapiens	74-77
8473303-10	1993	These findings raise the possibility that Zn2+ plays a regulatory role in uPA-mediated fibrinolysis by promoting effective localization of Sc-uPA at the clot surface.	Zinc	42-46	plasminogen activator, urokinase	Homo sapiens	142-145
24198081-3	1993	The oxidation process was inhibited in the presence of other ions, and the inhibitive effect was in the following order: Co(II) < Mo(VI) < Cd(II) < Zn(II) < Ti(IV) < V(V).	Zinc	157-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
8341015-8	1993	From these results, we conclude that a marked elevation of the plasma level of Cu,Zn-SOD in hemodialysis patients was caused by an increase in the enzymatically inactive Cu,Zn-SOD monomer.	Zinc	82-84	superoxide dismutase 1	Homo sapiens	85-88
8341015-8	1993	From these results, we conclude that a marked elevation of the plasma level of Cu,Zn-SOD in hemodialysis patients was caused by an increase in the enzymatically inactive Cu,Zn-SOD monomer.	Zinc	82-84	superoxide dismutase 1	Homo sapiens	176-179
8452570-3	1993	The sulfhydryl group reducing agent dithiothreitol (DTT) protected the nuclei from the effects of heavy metals; DDT (1 mM) almost completely blocked Zn(2+)- or Cu(2+)-induced Ca2+ release and inhibition of Ca2+ uptake.	Zinc	149-151	carbonic anhydrase 2	Rattus norvegicus	175-178
8464801-9	1993	Supplementing the saline drinking water with any of the three Zn compounds significantly reduced the incidence of eggshell defects and in some cases improved shell breaking strength, the concentration of CaBP, and the activity of CA.	Zinc	62-64	calcium-binding protein	Gallus gallus	204-208
8452570-2	1993	In isolated hepatic nuclei, the heavy metals Zn2+ and Cu2+ (10 microM) inhibited Ca2+ uptake and caused a prompt release of Ca2+ from preloaded nuclei in a concentration-dependent manner, with Zn2+ being more effective than Cu2+.	Zinc	45-49	carbonic anhydrase 2	Rattus norvegicus	81-84
8452570-2	1993	In isolated hepatic nuclei, the heavy metals Zn2+ and Cu2+ (10 microM) inhibited Ca2+ uptake and caused a prompt release of Ca2+ from preloaded nuclei in a concentration-dependent manner, with Zn2+ being more effective than Cu2+.	Zinc	45-49	carbonic anhydrase 2	Rattus norvegicus	124-127
8441924-2	1993	The Zn-insulin hexamer dissociated reversibly by dialysis against the Zn-free electrophoresis buffer.	Zinc	4-6	insulin	Homo sapiens	7-14
8441924-2	1993	The Zn-insulin hexamer dissociated reversibly by dialysis against the Zn-free electrophoresis buffer.	Zinc	70-72	insulin	Homo sapiens	7-14
8441924-7	1993	As insulin is probably released from the beta cells in the relatively stable form of Zn-insulin hexamers, selective monomer assays might underestimate the total content of immunoreactive insulin in the biological fluids.	Zinc	85-87	insulin	Homo sapiens	3-10
8441924-7	1993	As insulin is probably released from the beta cells in the relatively stable form of Zn-insulin hexamers, selective monomer assays might underestimate the total content of immunoreactive insulin in the biological fluids.	Zinc	85-87	insulin	Homo sapiens	88-95
8441924-7	1993	As insulin is probably released from the beta cells in the relatively stable form of Zn-insulin hexamers, selective monomer assays might underestimate the total content of immunoreactive insulin in the biological fluids.	Zinc	85-87	insulin	Homo sapiens	88-95
8441924-8	1993	Electroimmunoassay of Zn-insulin immunoreactive antigens in human urine defines a normal reference range of 10-25 ng/ml.	Zinc	22-24	insulin	Homo sapiens	25-32
8387434-3	1993	Serum from patients with untreated Graves" disease had a significantly higher concentration of Cu, Zn-SOD and higher SOD-like activity than those from normal subjects, patients with Graves" disease under treatment over one year, patients with Graves" disease in remission, and patients with untreated Hashimoto"s disease.	Zinc	99-101	superoxide dismutase 1	Homo sapiens	102-105
8381668-1	1993	Fluorescence Line Narrowing (FLN) spectroscopy was employed to compare the environment around the porphyrin in folded and unfolded Zn-substituted cytochrome c (Zn cyt c).	Zinc	131-133	cytochrome c, somatic	Homo sapiens	146-158
8452570-2	1993	In isolated hepatic nuclei, the heavy metals Zn2+ and Cu2+ (10 microM) inhibited Ca2+ uptake and caused a prompt release of Ca2+ from preloaded nuclei in a concentration-dependent manner, with Zn2+ being more effective than Cu2+.	Zinc	193-197	carbonic anhydrase 2	Rattus norvegicus	124-127
8452570-6	1993	The present study demonstrates that Zn2+ and Cu2+ have a stimulatory effect on Ca2+ release from isolated rat liver nuclei, and that the SH group may play an important role in the Ca(2+)-releasing mechanism in liver nuclei.	Zinc	36-40	carbonic anhydrase 2	Rattus norvegicus	79-82
7681680-8	1993	IL-6 (100 U/mL) was found to have an additive effect on MT synthesis above that of Zn alone (1-50 microM) or Zn plus dexamethasone (1 microM).	Zinc	83-85	interleukin 6	Rattus norvegicus	0-4
7681680-8	1993	IL-6 (100 U/mL) was found to have an additive effect on MT synthesis above that of Zn alone (1-50 microM) or Zn plus dexamethasone (1 microM).	Zinc	109-111	interleukin 6	Rattus norvegicus	0-4
1334093-8	1992	Thus we conclude that inactivation of alpha 1-PI is mediated in the H2O2/Cu,Zn-SOD system via the generation of .OH by free Cu2+ released from oxidatively damaged SOD.	Zinc	76-78	serpin family A member 1	Homo sapiens	38-48
10046914-0	1992	Theory of Zn-enhanced disordering in GaAs/AlAs superlattices.	Zinc	10-12	5'-aminolevulinate synthase 1	Homo sapiens	42-46
1334093-8	1992	Thus we conclude that inactivation of alpha 1-PI is mediated in the H2O2/Cu,Zn-SOD system via the generation of .OH by free Cu2+ released from oxidatively damaged SOD.	Zinc	76-78	superoxide dismutase 1	Homo sapiens	79-82
1334093-8	1992	Thus we conclude that inactivation of alpha 1-PI is mediated in the H2O2/Cu,Zn-SOD system via the generation of .OH by free Cu2+ released from oxidatively damaged SOD.	Zinc	76-78	superoxide dismutase 1	Homo sapiens	163-166
1478067-5	1992	The metal ions Cu2+, Zn2+, Fe2+ and Fe3+ inhibited heparin binding, with half-maximal inhibition of binding to lactoferrin occurring between 600 microM and 1 mM and for lysozyme between 500 and 800 microM.	Zinc	21-25	lysozyme	Homo sapiens	169-177
1294258-4	1992	The purified enzyme differs by its physico-chemical characteristics from cytosolic Cu,Zn-SOD and pertains to a new class of SOD, the so-called extracellular SOD, detected in some biological fluids.	Zinc	86-88	superoxide dismutase 1	Homo sapiens	89-92
1332689-0	1992	Investigation of the electron-transfer properties of cytochrome c oxidase covalently cross-linked to Fe- or Zn-containing cytochrome c.	Zinc	108-110	cytochrome c, somatic	Homo sapiens	53-65
1446663-9	1992	5-Lipoxygenase is strongly inhibited by low concentrations (< or = 10 microM) of Zn2+ and Cu2+.	Zinc	84-88	arachidonate 5-lipoxygenase	Homo sapiens	0-14
1332689-4	1992	Free Fe-containing cytochrome c was, however, able to transfer electrons to cytochrome a in covalent complexes containing either Fe- or Zn-containing cytochrome c.	Zinc	136-138	cytochrome c, somatic	Homo sapiens	150-162
1332689-0	1992	Investigation of the electron-transfer properties of cytochrome c oxidase covalently cross-linked to Fe- or Zn-containing cytochrome c.	Zinc	108-110	cytochrome c, somatic	Homo sapiens	122-134
1332689-1	1992	Complexes of cytochrome c oxidase and cytochrome c (Fe- or Zn-containing) have been prepared by 1-ethyl-3-[3-(dimethylamino)propyl]carbodi-imide (EDC) cross-linking.	Zinc	59-61	cytochrome c, somatic	Homo sapiens	13-25
1332689-1	1992	Complexes of cytochrome c oxidase and cytochrome c (Fe- or Zn-containing) have been prepared by 1-ethyl-3-[3-(dimethylamino)propyl]carbodi-imide (EDC) cross-linking.	Zinc	59-61	cytochrome c, somatic	Homo sapiens	38-50
1332689-4	1992	Free Fe-containing cytochrome c was, however, able to transfer electrons to cytochrome a in covalent complexes containing either Fe- or Zn-containing cytochrome c.	Zinc	136-138	cytochrome c, somatic	Homo sapiens	19-31
1326693-7	1992	In Ca(2+)-containing medium the Ca2+ transient induced by ASA was not affected by organic Ca2+ channel blockers, but decreased when Co2+, Mn2+ or Zn2+ were present in the extracellular medium.	Zinc	146-150	carbonic anhydrase 2	Rattus norvegicus	32-35
1419966-15	1992	These findings suggest that: (1) Mg2+ binds to all S100s, and at least one of the Mg2+ binding sites of S100 molecule is the same as the Ca2+ binding site; (2) Zn2+ binds to S100s, although the binding site(s) is/are different from Ca(2+)- or Mg(2+)-binding site(s), and the environment of Zn2+ nuclei will not change even though Ca2+ binds to S100s.	Zinc	160-164	S100 calcium binding protein B	Homo sapiens	51-55
1440503-8	1992	Costimulation of PMA- or Zn(2+)-treated platelets with low doses of A23187, however, restored the stabilization of platelet-fibrinogen interactions.	Zinc	25-31	fibrinogen beta chain	Homo sapiens	124-134
1438163-9	1992	Such amino acid substitutions also substantially reduced the Zn-induced insulin hexamer formation.	Zinc	61-63	insulin	Homo sapiens	72-79
1424126-6	1992	The addition of the metal ion buffer N-hydroxyethylethylenediaminetriacetic acid, along with low concentrations of Zn and Mg, as used in the IFCC/RM/ALP, reduced the slow loss in activity over time, as did decreasing the reaction temperature to 30 degrees C, but had no effect on the early rapid decay in activity seen in the first minute.	Zinc	115-117	alkaline phosphatase, placental	Homo sapiens	149-152
1419966-1	1992	The interactions of the S100 protein (S100) with metal cations such as Ca2+, Mg2+, Zn2+ and K+ were studied by the metal n.m.r.	Zinc	83-87	S100 calcium binding protein B	Homo sapiens	24-28
1419966-1	1992	The interactions of the S100 protein (S100) with metal cations such as Ca2+, Mg2+, Zn2+ and K+ were studied by the metal n.m.r.	Zinc	83-87	S100 calcium binding protein B	Homo sapiens	38-42
1419966-14	1992	of the Zn(2+)-S100 solutions.	Zinc	7-9	S100 calcium binding protein B	Homo sapiens	14-18
1440503-3	1992	Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding.	Zinc	28-32	fibrinogen beta chain	Homo sapiens	115-125
1440503-4	1992	Sixty min after binding to platelets, approximately 80% of bound fibrinogen remained reversibly associated with Zn(2+)- or PMA-treated platelets and failed to associate with the Triton X-100 insoluble cytoskeleton.	Zinc	112-114	fibrinogen beta chain	Homo sapiens	65-75
1733046-1	1992	Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this phenomenon is unique to Zn treatment or the age of the animal.	Zinc	129-131	metallothionein 1	Rattus norvegicus	43-60
1304529-5	1992	Erythrocyte superoxide dismutase and Cu, Zn-SOD in plasma blood changed significantly with maturation, by term Cu, Zn-SOD activity reached a level higher than in adults.	Zinc	41-43	superoxide dismutase 1	Homo sapiens	44-47
1633859-5	1992	Thus, p97 may have a Zn-binding potential, unique amongst the transferrin superfamily.	Zinc	21-23	transferrin	Homo sapiens	62-73
1733046-6	1992	MT-1 had a shorter half-life than MT-2 in Zn-treated adults (21 vs 33 hr) and in nontreated immature rats (49 vs 73 hr).	Zinc	42-44	metallothionein 1	Rattus norvegicus	0-4
18647706-1	1992	UNLABELLED: Thymulin (FTS) is a thymic hormone, the bioactivity of which depends on zinc (Zn) incorporation in its molecule (FTS bioactive form: Zn-FTS).	Zinc	90-92	AKT interacting protein	Homo sapiens	22-25
18647706-1	1992	UNLABELLED: Thymulin (FTS) is a thymic hormone, the bioactivity of which depends on zinc (Zn) incorporation in its molecule (FTS bioactive form: Zn-FTS).	Zinc	90-92	AKT interacting protein	Homo sapiens	125-128
18647706-1	1992	UNLABELLED: Thymulin (FTS) is a thymic hormone, the bioactivity of which depends on zinc (Zn) incorporation in its molecule (FTS bioactive form: Zn-FTS).	Zinc	90-92	AKT interacting protein	Homo sapiens	125-128
18647706-2	1992	Many hormones (T3, GH, PRL, Gn-RH 6-endorphin) and Zn are able to increase thymus trophism and Zn-FTS circulating levels, even in old animals, suggesting that age dependent thymic involution is a reversible phenomenon.	Zinc	51-53	AKT interacting protein	Homo sapiens	98-101
18647706-7	1992	In all these patients, age-related differences of Zn-FTS circulating levels were lost and Zn-FTS titers were homogeneously low or high according to Zn levels.	Zinc	50-52	AKT interacting protein	Homo sapiens	53-56
18647706-14	1992	IN CONCLUSION: (i) Reduced Zn-FTS levels in patients affected with uremia or prolactinoma and the increased Zn-FTS titers present in acromegalic patients are related to low and high Zn circulating levels, respectively, underlining the importance of Zn in regulating thymulin secretion.	Zinc	27-29	AKT interacting protein	Homo sapiens	30-33
18647706-14	1992	IN CONCLUSION: (i) Reduced Zn-FTS levels in patients affected with uremia or prolactinoma and the increased Zn-FTS titers present in acromegalic patients are related to low and high Zn circulating levels, respectively, underlining the importance of Zn in regulating thymulin secretion.	Zinc	108-110	AKT interacting protein	Homo sapiens	111-114
18647706-15	1992	(ii) When spontaneous (or induced) hyper- or hypo-zincemia occurs, age-related differences of Zn-FTS titers are lost, suggesting that Zn may overcome the effect of age on thymic function.	Zinc	94-96	AKT interacting protein	Homo sapiens	97-100
1293311-5	1992	Rat liver MT-1 and MT-2 containing different metals (Ag, Cu, and Zn) inhibited the antibodies as effectively as CdMT.	Zinc	65-67	metallothionein 1	Rattus norvegicus	10-23
1733046-1	1992	Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this phenomenon is unique to Zn treatment or the age of the animal.	Zinc	129-131	metallothionein 1	Rattus norvegicus	62-66
1733046-1	1992	Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this phenomenon is unique to Zn treatment or the age of the animal.	Zinc	214-216	metallothionein 1	Rattus norvegicus	43-60
1733046-1	1992	Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this phenomenon is unique to Zn treatment or the age of the animal.	Zinc	214-216	metallothionein 1	Rattus norvegicus	62-66
1733046-4	1992	Pulse-labeling experiments were conducted to determine the half-lives of MT-1 and MT-2 in liver of adult rats (75-day-old), immature rats (1-day-old), and mature rats treated with single dosages of Zn (1 mmol/kg, sc), Cd (10 mumol/kg, sc), or ethanol (109 mmol/kg, po).	Zinc	198-200	metallothionein 1	Rattus norvegicus	73-86
1733046-5	1992	Atomic absorption spectrometry was utilized to measure the Zn, Cu, and Cd contents of MT-1 and MT-2 obtained in selected experimental groups.	Zinc	59-61	metallothionein 1	Rattus norvegicus	86-99
1952945-4	1991	The affinity of both sites for gastrin was increased in the presence of 100 microM Zn2+ or Ni2+ ions.	Zinc	83-87	gastrin	Bos taurus	31-38
1952945-8	1991	We therefore propose that the ternary complex of gastrin, Zn2+ ions, and albumin may play a physiological role in the serum transport of Zn2+ ions and in the uptake of Zn2+ ions from the lumen of the gastrointestinal tract.	Zinc	137-141	gastrin	Bos taurus	49-56
1952945-8	1991	We therefore propose that the ternary complex of gastrin, Zn2+ ions, and albumin may play a physiological role in the serum transport of Zn2+ ions and in the uptake of Zn2+ ions from the lumen of the gastrointestinal tract.	Zinc	137-141	gastrin	Bos taurus	49-56
1817262-4	1991	As does the bona fide protein, the recombinant calreticulin binds calcium and undergoes changes in its conformation upon Zn2+ binding.	Zinc	121-125	calreticulin	Homo sapiens	47-59
1665488-0	1991	Conjugates of superoxide dismutase with the Fc fragment of immunoglobulin G. We constructed conjugates of superoxide dismutase (SOD) and the Fc fragment of human immunoglobulin G. The lysyl residues of bovine erythrocyte Cu,Zn-SOD were covalently linked with cysteine residues of the Fc fragment using N-succinimidyl 4-(N-maleimido)-butylate as a crosslinking agent.	Zinc	224-226	superoxide dismutase 1	Homo sapiens	14-34
1665488-0	1991	Conjugates of superoxide dismutase with the Fc fragment of immunoglobulin G. We constructed conjugates of superoxide dismutase (SOD) and the Fc fragment of human immunoglobulin G. The lysyl residues of bovine erythrocyte Cu,Zn-SOD were covalently linked with cysteine residues of the Fc fragment using N-succinimidyl 4-(N-maleimido)-butylate as a crosslinking agent.	Zinc	224-226	superoxide dismutase 1	Homo sapiens	106-126
1665488-0	1991	Conjugates of superoxide dismutase with the Fc fragment of immunoglobulin G. We constructed conjugates of superoxide dismutase (SOD) and the Fc fragment of human immunoglobulin G. The lysyl residues of bovine erythrocyte Cu,Zn-SOD were covalently linked with cysteine residues of the Fc fragment using N-succinimidyl 4-(N-maleimido)-butylate as a crosslinking agent.	Zinc	224-226	superoxide dismutase 1	Homo sapiens	128-131
1815583-0	1991	Binding of Zn(II) ions to alpha-lactalbumin.	Zinc	11-17	lactalbumin alpha	Homo sapiens	26-43
1815583-4	1991	It was concluded that alpha-lactalbumin possess several relatively strong Zn(II) binding sites, which are filled sequentially, the process being accompanied by protein aggregation.	Zinc	74-80	lactalbumin alpha	Homo sapiens	22-39
1815583-6	1991	Zn(II) binding to aggregated forms of alpha-lactalbumin increases its affinity to bis-ANS.	Zinc	0-6	lactalbumin alpha	Homo sapiens	38-55
1718728-7	1991	Treatment with the PTH agonist [Nle8,18,Tyr34]bovine PTH(1-34)NH2 [(NlePTH(1-34)] also markedly down-regulates PTH receptors in UMR 106 cells, but this effect is only partially inhibited in Zn(++)-induced UMR 4-7 cells.	Zinc	190-196	parathyroid hormone	Rattus norvegicus	53-56
1824001-3	1991	In the case of Zn deficient group, the inhibitions were up to 51% compared to 27% for the control and became higher as the increasing concentration of Met-Enk.	Zinc	15-17	preproenkephalin	Mus musculus	155-158
1811283-2	1991	In the present study the Zn-containing Cd-BP was assumed to be alcohol dehydrogenase (ADH) from the similarity in several characteristic properties such as molecular size, isoelectric point, Zn content and enzyme activity.	Zinc	25-27	aldo-keto reductase family 1 member A1	Rattus norvegicus	63-84
1811283-2	1991	In the present study the Zn-containing Cd-BP was assumed to be alcohol dehydrogenase (ADH) from the similarity in several characteristic properties such as molecular size, isoelectric point, Zn content and enzyme activity.	Zinc	25-27	aldo-keto reductase family 1 member A1	Rattus norvegicus	86-89
1811283-2	1991	In the present study the Zn-containing Cd-BP was assumed to be alcohol dehydrogenase (ADH) from the similarity in several characteristic properties such as molecular size, isoelectric point, Zn content and enzyme activity.	Zinc	191-193	aldo-keto reductase family 1 member A1	Rattus norvegicus	63-84
1811283-2	1991	In the present study the Zn-containing Cd-BP was assumed to be alcohol dehydrogenase (ADH) from the similarity in several characteristic properties such as molecular size, isoelectric point, Zn content and enzyme activity.	Zinc	191-193	aldo-keto reductase family 1 member A1	Rattus norvegicus	86-89
1811283-3	1991	Zn bound to non-active site in ADH was replaced with Cd both in vivo and in vitro.	Zinc	0-2	aldo-keto reductase family 1 member A1	Rattus norvegicus	31-34
1824001-5	1991	These findings suggest that Zn may interfere with the role of Met-Enk on BMC.	Zinc	28-30	preproenkephalin	Mus musculus	66-69
1932114-6	1991	The half-life of chicken MT (cMT) mRNA in uninduced chicken embryo hepatocytes was 3.6 h. Induction of cMT mRNA by pretreatment of these cells with zinc (Zn) prior to exposure to AMD, did not alter the half-life of cMT mRNA significantly.	Zinc	154-156	metallothionein 4	Gallus gallus	25-27
1680129-5	1991	Synthesis of soluble protein, levels of mRNAs for beta-actin and glyceraldehyde-3-phosphate dehydrogenase, and induction of metallothionein mRNA by Zn2+ were unaffected by H-8 at concentrations that inhibited the T3-induced accumulation of lipogenic enzymes and their mRNAs.	Zinc	148-152	metallothionein 4	Gallus gallus	124-139
1654278-0	1991	Zn(2+)-induced deprotonation of a peptide nitrogen in angiotensin I.	Zinc	0-2	angiotensinogen	Homo sapiens	54-67
1888732-1	1991	We report here for the first time that Zn2+ is an effective inhibitor of renin and the protease from HIV-1, two aspartyl proteinases of considerable physiological importance.	Zinc	39-43	renin	Homo sapiens	73-78
1888732-2	1991	Inhibition of renin is noncompetitive and is accompanied by binding of 1 mol of Zn2+/mol of enzyme.	Zinc	80-84	renin	Homo sapiens	14-19
1654278-1	1991	The interaction of Zn2+ with angiotensin I, a decapeptide containing two histidyl residues, has been studied by 1H-NMR spectroscopy in both water and dimethylsulfoxide.	Zinc	19-23	angiotensinogen	Homo sapiens	29-42
1907025-1	1991	Size-exclusion chromatography and sedimentation equilbrium studies demonstrated that zinc ion (Zn2+) induced the dimerization of human growth hormone (hGH).	Zinc	95-99	growth hormone 1	Homo sapiens	135-149
1885582-1	1991	Captopril ((2S)-1-(3-mercapto-2-methyl-propionyl)-L-proline) inhibited the bifunctional, Zn(2+)-containing enzyme leukotriene A4 hydrolase/aminopeptidase reversibly and competitively with Ki = 6.0 microM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p-nitroanilide hydrolysis at pH 8.	Zinc	89-92	leukotriene A4 hydrolase	Homo sapiens	114-138
1961021-5	1991	The peak increase of fragments from HL-60 occurred between one and two hours of incubation, with TNF concentrations of 10 U/ml or higher, and was inhibitable by 1 mM Zn2+.	Zinc	166-170	tumor necrosis factor	Homo sapiens	97-100
1871124-2	1991	Deletion of the DNA-binding domain or of the second Zn finger or a point mutation in the Zn catenation site in the second finger blocked the ability of GR to mediate repression of the IL-6 promoter.	Zinc	52-54	nuclear receptor subfamily 3 group C member 1	Homo sapiens	152-154
1871124-3	1991	Unexpectedly, deletion of the first Zn finger, a point mutation in the Zn-catenation site in the first finger, or one in the steroid-specificity domain at the base of the first finger converted GR into a dexamethasone-responsive activator that enhanced basal and interleukin 1-induced IL-6 promoter function.	Zinc	36-38	nuclear receptor subfamily 3 group C member 1	Homo sapiens	194-196
1871124-3	1991	Unexpectedly, deletion of the first Zn finger, a point mutation in the Zn-catenation site in the first finger, or one in the steroid-specificity domain at the base of the first finger converted GR into a dexamethasone-responsive activator that enhanced basal and interleukin 1-induced IL-6 promoter function.	Zinc	71-73	nuclear receptor subfamily 3 group C member 1	Homo sapiens	194-196
1781789-0	1991	Regulation of protein kinase C by Zn(2+)-dependent interaction with actin.	Zinc	34-40	proline rich transmembrane protein 2	Homo sapiens	14-30
1781789-2	1991	Some of these effects may be mediated by the protein kinase C (PKC) family of enzymes, since an influx of Zn2+ greatly increases their binding of regulatory ligand phorbol ester and induces their translocation from cytosol to the cytoskeleton.	Zinc	106-110	proline rich transmembrane protein 2	Homo sapiens	45-61
1781789-2	1991	Some of these effects may be mediated by the protein kinase C (PKC) family of enzymes, since an influx of Zn2+ greatly increases their binding of regulatory ligand phorbol ester and induces their translocation from cytosol to the cytoskeleton.	Zinc	106-110	proline rich transmembrane protein 2	Homo sapiens	63-66
1781789-3	1991	Using a model with purified components, we now show that Zn2+ acts by forming a phospholipid-dependent complex of PKC with filamentous actin, which results in expression of new binding sites for phorbol ester and phosphorylation of actin.	Zinc	57-61	proline rich transmembrane protein 2	Homo sapiens	114-117
1649623-2	1991	Previous metal analyses of somatic ACE have indicated a zinc stoichiometry of 1 mol of Zn2+/mol of ACE and inhibitor-binding studies have found 1 mol of inhibitor bound/mol of enzyme.	Zinc	87-91	angiotensin I converting enzyme	Homo sapiens	35-38
1649623-2	1991	Previous metal analyses of somatic ACE have indicated a zinc stoichiometry of 1 mol of Zn2+/mol of ACE and inhibitor-binding studies have found 1 mol of inhibitor bound/mol of enzyme.	Zinc	87-91	angiotensin I converting enzyme	Homo sapiens	99-102
1774132-5	1991	Zn-unbound bioinactive thymulin form (FTS) levels were in the normal range.	Zinc	0-2	AKT interacting protein	Homo sapiens	38-41
1676967-6	1991	All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II).	Zinc	207-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	215-221
24242957-1	1991	Fluorescence line narrowing (FLN) spectroscopy was used to study the role of the polypeptide chain in influencing the spectrum of Zn-substituted cytochrome c (Zn cyt c) and metal-free cyt c (porphyrin cyt c).	Zinc	130-132	cytochrome c, somatic	Homo sapiens	145-157
1645680-5	1991	Polyubiquitin RNA is expressed equally in ectodermal and mesoendodermal tissues and is induced in both tissue fractions by treatment of pluteus larvae with Zn(II).	Zinc	156-158	polyubiquitin	Strongylocentrotus purpuratus	0-13
1894879-1	1991	Human mixed lymphocyte cultures (hMLC) were used to examine the relationship between mitogenic stimuli (MITO), synthetic human calcitonin (hCT), and human insulin (hINS) on zinc (Zn) transport kinetics.	Zinc	179-181	insulin	Homo sapiens	155-162
1993673-11	1991	Metals such as Cu2+ or Zn2+, but not Cd2+ or Mn2+, when dissolved in a balanced salt solution buffered with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, induced changes in the transferrin-independent iron transport system.	Zinc	23-27	transferrin	Homo sapiens	183-194
1832836-10	1991	The pH-dependent step can be blocked by Zn2+ and Cd2+ ions which probably bind to negatively charged residues on IF1, thereby preventing their protonation and conversion of the protein to an inhibitory conformation.	Zinc	40-44	NDV-induced circulating interferon	Mus musculus	113-116
1924558-1	1991	A plasmid was constructed by fusion of a selectable mammalian gene, hamster adenine phosphoribosyltransferase (APRT), to the Zn(2+)-inducible sheep metallothionein I (MT I) promoter.	Zinc	125-131	adenine phosphoribosyltransferase	Cricetulus griseus	111-115
1924558-4	1991	We have shown that in the absence of Zn2+, there is very low expression of a sheep MT I-APRT fusion gene in stable CHO cells transformants; induction of APRT mRNA and enzyme activity by Zn2+ produced a "threshold" response, from low basal levels to high induced levels, in Zn2+ responsive stable transformant clones.	Zinc	186-190	adenine phosphoribosyltransferase	Cricetulus griseus	153-157
1924558-4	1991	We have shown that in the absence of Zn2+, there is very low expression of a sheep MT I-APRT fusion gene in stable CHO cells transformants; induction of APRT mRNA and enzyme activity by Zn2+ produced a "threshold" response, from low basal levels to high induced levels, in Zn2+ responsive stable transformant clones.	Zinc	186-190	adenine phosphoribosyltransferase	Cricetulus griseus	153-157
1924558-6	1991	All stable transformants analyzed displayed Zn(2+)-inducible APRT enzyme activity.	Zinc	44-50	adenine phosphoribosyltransferase	Cricetulus griseus	61-65
2007899-4	1991	After 7 d of hyperoxia exposure, the Zn-repleted and ad libitum-fed groups consistently had increased activity of lung CuZn-superoxide dismutase (CuZnSOD), glutathione peroxidase and catalase; but changes in CuZnSOD activity were not related to lung Cu or Zn concentrations.	Zinc	37-39	superoxide dismutase 1	Rattus norvegicus	119-144
2007899-4	1991	After 7 d of hyperoxia exposure, the Zn-repleted and ad libitum-fed groups consistently had increased activity of lung CuZn-superoxide dismutase (CuZnSOD), glutathione peroxidase and catalase; but changes in CuZnSOD activity were not related to lung Cu or Zn concentrations.	Zinc	37-39	superoxide dismutase 1	Rattus norvegicus	146-153
2007899-4	1991	After 7 d of hyperoxia exposure, the Zn-repleted and ad libitum-fed groups consistently had increased activity of lung CuZn-superoxide dismutase (CuZnSOD), glutathione peroxidase and catalase; but changes in CuZnSOD activity were not related to lung Cu or Zn concentrations.	Zinc	37-39	catalase	Rattus norvegicus	183-191
2007899-4	1991	After 7 d of hyperoxia exposure, the Zn-repleted and ad libitum-fed groups consistently had increased activity of lung CuZn-superoxide dismutase (CuZnSOD), glutathione peroxidase and catalase; but changes in CuZnSOD activity were not related to lung Cu or Zn concentrations.	Zinc	37-39	superoxide dismutase 1	Rattus norvegicus	208-215
1827378-7	1991	Our conclusion is that Zn-containing insulin partly inactivates regular insulin when administered in the same syringe, and this may have an impact on the long-term treatment of the diabetic patient.	Zinc	23-25	insulin	Homo sapiens	37-44
1671209-0	1991	X-ray structure of an unusual Ca2+ site and the roles of Zn2+ and Ca2+ in the assembly, stability, and storage of the insulin hexamer.	Zinc	57-61	insulin	Homo sapiens	118-125
1827378-7	1991	Our conclusion is that Zn-containing insulin partly inactivates regular insulin when administered in the same syringe, and this may have an impact on the long-term treatment of the diabetic patient.	Zinc	23-25	insulin	Homo sapiens	72-79
1999294-0	1991	A nuclear factor requires Zn2+ to bind a regulatory MRE element of the mouse gene encoding metallothionein-1.	Zinc	26-30	metallothionein 1	Mus musculus	91-108
1846352-8	1991	The results demonstrate a functional resemblance between LTA4 hydrolase and certain metallohydrolases, consistent with a molecular resemblance at their putative Zn2(+)-binding sites.	Zinc	161-167	leukotriene A4 hydrolase	Homo sapiens	57-71
18965065-6	1990	The flux of Zn(II) was about 40 times that of Cu(II) and 100 times that of Co(II) when their concentrations in the sample were equal.	Zinc	12-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81
2012830-1	1991	The self-association of Zn-free human insulin, Zn-free insulin analogue B13-glutamine, 2-Zn insulin and cobalt(III) human insulin in the millimolar concentration range has been investigated by measuring the osmotic pressure at pH 7.5 in 0.05 M NaCl, 25 degrees C. The pH dependence of association has been measured in the pH range 6.8-9.	Zinc	47-49	insulin	Homo sapiens	55-62
2012830-1	1991	The self-association of Zn-free human insulin, Zn-free insulin analogue B13-glutamine, 2-Zn insulin and cobalt(III) human insulin in the millimolar concentration range has been investigated by measuring the osmotic pressure at pH 7.5 in 0.05 M NaCl, 25 degrees C. The pH dependence of association has been measured in the pH range 6.8-9.	Zinc	47-49	insulin	Homo sapiens	55-62
2012830-1	1991	The self-association of Zn-free human insulin, Zn-free insulin analogue B13-glutamine, 2-Zn insulin and cobalt(III) human insulin in the millimolar concentration range has been investigated by measuring the osmotic pressure at pH 7.5 in 0.05 M NaCl, 25 degrees C. The pH dependence of association has been measured in the pH range 6.8-9.	Zinc	47-49	insulin	Homo sapiens	55-62
2012830-3	1991	Maximal association of hexamer has been observed for Zn-free human insulin at high concentration (2-7 mM) and physiological pH.	Zinc	53-55	insulin	Homo sapiens	67-74
2046801-3	1991	There was also a correlation between decreased plasma Zn and erythrocyte SOD activity (r = 0.58, p less than 0.02) and between decreased plasma Cu and erythrocyte SOD (r = 0.60, p less than 0.02).	Zinc	54-56	superoxide dismutase 1	Homo sapiens	73-76
2270485-6	1990	Mutational analysis showed that a cluster of three residues (His18, His21, and Glu174) in hGH and His188 from the hPRLbp (conserved in all PRL receptors but not GH receptors) are probable Zn2+ ligands.	Zinc	188-192	prolactin	Homo sapiens	115-118
1985897-5	1991	DNA binding of NF-kappa B was specifically blocked by the chelating agent 1,10-orthophenantroline and could only be reconstituted by addition of Zn2+.	Zinc	145-149	nuclear factor kappa B subunit 1	Homo sapiens	15-25
1815469-4	1991	Hepatic microsomal cytochrome P-450 content was significantly decreased after treatment with Co, Cd, Zn and Ni and was not changed by Hg.	Zinc	101-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35
1815469-6	1991	Co, Cd, Zn and Ni salts decreased the activity of 5-aminolevulinic acid synthetase which shows that the decreased cytochrome P-450 content was probably due to a decrease of its synthesis.	Zinc	8-10	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	114-130
2012830-1	1991	The self-association of Zn-free human insulin, Zn-free insulin analogue B13-glutamine, 2-Zn insulin and cobalt(III) human insulin in the millimolar concentration range has been investigated by measuring the osmotic pressure at pH 7.5 in 0.05 M NaCl, 25 degrees C. The pH dependence of association has been measured in the pH range 6.8-9.	Zinc	24-26	insulin	Homo sapiens	38-45
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	interleukin 1 beta	Homo sapiens	56-65
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	interleukin 1 beta	Homo sapiens	103-112
2213249-9	1990	The MT induction by Fe, as well as related depression in plasma Zn, was completely inhibited by actinomycin D.	Zinc	64-66	metallothionein 4	Gallus gallus	4-6
2213249-10	1990	Zn depletion eliminated the accumulation of hepatic Zn and MT protein following ip injection of Fe or endotoxin, but not of cadmium, despite marked elevation of hepatic MTmRNA.	Zinc	0-2	metallothionein 4	Gallus gallus	59-61
2237916-5	1990	Distribution profiles of Cd and Zn by gel filtration chromatography indicated that Cd replaced Zn bound to both alcohol dehydrogenase (ADH) and MT.	Zinc	32-34	aldo-keto reductase family 1 member A1	Rattus norvegicus	112-133
2237916-5	1990	Distribution profiles of Cd and Zn by gel filtration chromatography indicated that Cd replaced Zn bound to both alcohol dehydrogenase (ADH) and MT.	Zinc	95-97	aldo-keto reductase family 1 member A1	Rattus norvegicus	112-133
1701013-3	1990	When assayed in the presence of calmodulin, many divalent metals (Ni2+, Zn2+, Pb2+, Cd2+), besides Mn2+, increased modestly the phosphatase activity at low concentrations (10-100 microM) and inhibited it markedly at high concentrations.	Zinc	72-76	calmodulin	Bos taurus	32-42
1701013-4	1990	Ca2(+)-calmodulin stimulated phosphatase activity was antagonized by Ni2+, Zn2+, Fe2+, Cu2+, Pb2+, at low concentrations (50 microM), and by Ba2+, Cd2+ at slightly higher concentrations (greater than 100 microM); Mn2+ and Co2+ (50 microM to 1 mM) in fact augmented it.	Zinc	75-79	calmodulin	Bos taurus	7-17
2167660-14	1990	The rate of decrease in fluorescence induced by Zn2+, Co2+, Ni2+ or Cd2+ was stimulated by between 20 and 190% in the presence of vasopressin or angiotensin II.	Zinc	48-52	arginine vasopressin	Homo sapiens	130-141
2219126-8	1990	When Zn injection was preceded by a Cd injection, induction as measured by MT-1 mRNA and MT concentrations were approximately additive in liver.	Zinc	5-7	metallothionein 1	Rattus norvegicus	75-79
2219126-9	1990	In kidney, although Cd or Zn treatment separately had no effect on MT or MT-1 mRNA content, injection of Cd followed by Zn resulted in significantly increased levels of renal MT and MT-1 mRNA.	Zinc	120-122	metallothionein 1	Rattus norvegicus	182-186
2167660-14	1990	The rate of decrease in fluorescence induced by Zn2+, Co2+, Ni2+ or Cd2+ was stimulated by between 20 and 190% in the presence of vasopressin or angiotensin II.	Zinc	48-52	angiotensinogen	Homo sapiens	145-159
2363178-8	1990	The lowest dosages of Zn, Cd, dexamethasone, and ethanol that produced a significant increase in total MT content (MT-I plus MT-II) were 0.38, 0.005, 0.3, and 90 mmol/kg, respectively.	Zinc	22-24	metallothionein 1	Mus musculus	115-119
2383592-1	1990	At micromolar concentrations, zinc (Zn) and cadmium, but not other metals, greatly augmented binding of [3H]phorbol dibutyrate ([3H]PDBu) to protein kinase C (PKC) in cell homogenates and intact cells (in the presence of ionophore).	Zinc	36-38	proline rich transmembrane protein 2	Homo sapiens	141-157
2383592-1	1990	At micromolar concentrations, zinc (Zn) and cadmium, but not other metals, greatly augmented binding of [3H]phorbol dibutyrate ([3H]PDBu) to protein kinase C (PKC) in cell homogenates and intact cells (in the presence of ionophore).	Zinc	36-38	proline rich transmembrane protein 2	Homo sapiens	159-162
2383592-3	1990	The heavy-metal chelating agent 1,10-phenanthroline completely reversed the increased [3H]PDBu binding in cells pretreated with 65Zn and ionophore and this was associated with a decline of about 20% in cell-associated 65Zn, suggesting that a relatively small pool of intracellular Zn acts on PKC.	Zinc	130-132	proline rich transmembrane protein 2	Homo sapiens	292-295
2383592-5	1990	Phenanthroline also partially inhibited binding of [3H]PDBu to PKC in untreated cells and extracts in a Zn-reversible manner.	Zinc	104-106	proline rich transmembrane protein 2	Homo sapiens	63-66
2383592-6	1990	Therefore, cellular Zn appears to regulate the interaction of ligand with PKC.	Zinc	20-22	proline rich transmembrane protein 2	Homo sapiens	74-77
2383592-7	1990	PKC bound to a Zn affinity column and was eluted by metal-chelator, confirming that Zn interacts directly with PKC.	Zinc	15-17	proline rich transmembrane protein 2	Homo sapiens	0-3
2383592-7	1990	PKC bound to a Zn affinity column and was eluted by metal-chelator, confirming that Zn interacts directly with PKC.	Zinc	84-86	proline rich transmembrane protein 2	Homo sapiens	0-3
2383592-7	1990	PKC bound to a Zn affinity column and was eluted by metal-chelator, confirming that Zn interacts directly with PKC.	Zinc	84-86	proline rich transmembrane protein 2	Homo sapiens	111-114
2146236-7	1990	Incubation with the mAb anti-Tac significantly inhibited the proliferative response to Zn, indicating that this requires binding of IL-2 to its receptor.	Zinc	87-89	interleukin 2	Homo sapiens	132-136
2363178-8	1990	The lowest dosages of Zn, Cd, dexamethasone, and ethanol that produced a significant increase in total MT content (MT-I plus MT-II) were 0.38, 0.005, 0.3, and 90 mmol/kg, respectively.	Zinc	22-24	metallothionein 2	Mus musculus	125-130
2271488-1	1990	study of trifluoperazine-S100 protein interaction: effects of Ca2+ and Zn2+.	Zinc	71-75	S100 calcium binding protein B	Homo sapiens	25-29
2363684-3	1990	A chicken macrophage-cell line (HD11) that rapidly accretes incremental amounts of MT when stimulated with increasing concentrations of Zn2+ or Cd2+ was studied.	Zinc	136-140	metallothionein 4	Gallus gallus	83-85
2363684-4	1990	The maximum rate of MT accretion occurred at 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	55-59	metallothionein 4	Gallus gallus	20-22
2363684-5	1990	The absolute rate of MT accretion was less in macrophages incubated with 25 microM- as compared with 50 microM-Zn2+, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	111-115	metallothionein 4	Gallus gallus	21-23
2363684-5	1990	The absolute rate of MT accretion was less in macrophages incubated with 25 microM- as compared with 50 microM-Zn2+, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	111-115	metallothionein 4	Gallus gallus	159-161
2363684-7	1990	Compared with macrophages continually incubated with 50 microM-Zn2+, removal of Zn2+ from medium previously containing 50 microM-Zn2+ decreased the absolute rate of MT accretion, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	80-84	metallothionein 4	Gallus gallus	165-167
2363684-7	1990	Compared with macrophages continually incubated with 50 microM-Zn2+, removal of Zn2+ from medium previously containing 50 microM-Zn2+ decreased the absolute rate of MT accretion, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	80-84	metallothionein 4	Gallus gallus	221-223
2363684-7	1990	Compared with macrophages continually incubated with 50 microM-Zn2+, removal of Zn2+ from medium previously containing 50 microM-Zn2+ decreased the absolute rate of MT accretion, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	80-84	metallothionein 4	Gallus gallus	165-167
2363684-7	1990	Compared with macrophages continually incubated with 50 microM-Zn2+, removal of Zn2+ from medium previously containing 50 microM-Zn2+ decreased the absolute rate of MT accretion, owing to decreased and increased rates of MT synthesis and degradation respectively.	Zinc	80-84	metallothionein 4	Gallus gallus	221-223
2363684-10	1990	When macrophages incubated with 50 microM-Zn2+ were subsequently incubated with 20 microM-Cd2+, rates of MT synthesis and accretion were decreased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	42-46	metallothionein 4	Gallus gallus	105-107
2363684-11	1990	When macrophages incubated with 20 microM-Cd2+ were subsequently incubated with 50 microM-Zn2+, rates of MT synthesis and accretion were increased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	90-94	metallothionein 4	Gallus gallus	105-107
2271488-3	1990	spectra were measured to investigate the effects of Ca2+ and Zn2+ on the interaction of trifluoperazine (TFP) with three S100 proteins.	Zinc	61-65	S100 calcium binding protein B	Homo sapiens	121-125
2271488-6	1990	These results suggested that TFP binds to each S100 protein in two ways: one is Ca2(+)- or Zn2(+)-dependent specific manner and another is Ca2(+)- or Zn2(+)-independent non-specific manner.	Zinc	91-97	S100 calcium binding protein B	Homo sapiens	47-51
2271488-6	1990	These results suggested that TFP binds to each S100 protein in two ways: one is Ca2(+)- or Zn2(+)-dependent specific manner and another is Ca2(+)- or Zn2(+)-independent non-specific manner.	Zinc	150-156	S100 calcium binding protein B	Homo sapiens	47-51
2337349-4	1990	Like the reduced protein, chemically modified S100b protein binds four Zn2+ ions in two classes of sites (of high and low affinities).	Zinc	71-75	S100 calcium binding protein B	Homo sapiens	46-51
2170039-1	1990	The effect of Zn2+ on the O2- generation and change in intracellular Ca2+ concentration ([Ca2+]i) of rat peritoneal neutrophils was studied.	Zinc	14-18	carbonic anhydrase 2	Rattus norvegicus	69-72
2170039-4	1990	In the absence of extracellular Ca2+, Zn2+ inhibited STZ-induced transient increase in [Ca2+]i in the concentration range that evoked a marked inhibition in the O2- generation.	Zinc	38-42	carbonic anhydrase 2	Rattus norvegicus	88-91
2170039-6	1990	From these results, it is suggested that Zn2+ inhibits STZ-induced release of Ca2+ from intracellular storage sites, resulting in the suppression of the activation mechanism of neutrophils.	Zinc	41-45	carbonic anhydrase 2	Rattus norvegicus	78-81
2281797-3	1990	The cytochrome P-450 level in Zn-treated female rats was decreased while the other metal salts did not change it.	Zinc	30-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-20
2383539-8	1990	All responses except the rise in serum Cu and gain in liver Zn were more intense at the higher than at the lower dose of TNF alpha.	Zinc	60-62	tumor necrosis factor	Homo sapiens	121-130
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	119-121	metallothionein 4	Gallus gallus	57-72
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	119-121	metallothionein 4	Gallus gallus	74-76
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	119-121	metallothionein 4	Gallus gallus	132-134
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	57-72
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	74-76
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	132-134
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	57-72
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	74-76
1691777-3	1990	The same pattern of accumulation was shown by pancreatic metallothionein (MT), which correlated highly with pancreatic Zn; that is, MT-associated Zn consistently accounted for 70 to 80% of pancreatic Zn.	Zinc	146-148	metallothionein 4	Gallus gallus	132-134
1966352-6	1990	Zn++ (50 microM) was required for binding of 125I-fibrinogen to neutrophils and the addition of Ca++ (2 mM) increased the binding 2-fold.	Zinc	0-4	fibrinogen beta chain	Homo sapiens	50-60
2353341-2	1990	Results showed that at Zn(II) concentrations exceeding 100 mumols/l, thrombin binding to fibrin was decreased concomitant with the Zn(II) concentration and time; at lower Zn(II) concentrations, thrombin adsorption was enhanced.	Zinc	23-29	coagulation factor II, thrombin	Homo sapiens	69-77
2353341-2	1990	Results showed that at Zn(II) concentrations exceeding 100 mumols/l, thrombin binding to fibrin was decreased concomitant with the Zn(II) concentration and time; at lower Zn(II) concentrations, thrombin adsorption was enhanced.	Zinc	131-137	coagulation factor II, thrombin	Homo sapiens	69-77
2353341-2	1990	Results showed that at Zn(II) concentrations exceeding 100 mumols/l, thrombin binding to fibrin was decreased concomitant with the Zn(II) concentration and time; at lower Zn(II) concentrations, thrombin adsorption was enhanced.	Zinc	131-137	coagulation factor II, thrombin	Homo sapiens	69-77
2353341-8	1990	We conclude that unlike Ca(II), Zn(II) is highly effective in modulating thrombin adsorption to fibrin.	Zinc	32-38	coagulation factor II, thrombin	Homo sapiens	73-81
2314921-7	1990	The larvacidal activity of macrophage supernatant fluids was abrogated by addition of either anti-TNF antisera or Zn+2, which has been shown to inhibit TNF-induced damage of tumour cells.	Zinc	114-118	tumor necrosis factor	Mus musculus	152-155
2079227-5	1990	While hrMn-SOD almost completely protected against loss of function and LDH release at 2 and 5 mg/L (p less than 0.01), it exacerbated the damage at 50 mg/L concentration (p less than 0.05 against controls), thus giving an even sharper bell-shaped curve than seen with the hrCu,Zn-SOD.	Zinc	278-280	superoxide dismutase 1	Homo sapiens	11-14
2079229-2	1990	Cu Zn-superoxide dismutase (Cu/Zn-SOD) was found increased in chemically induced tumors of the large bowel whereas metallothionein (MT), containing Zn and some Cu, was shown important for the response of tumors to chemotherapy.	Zinc	3-5	superoxide dismutase 1	Homo sapiens	28-37
33776569-2	2021	The aim of this study was to evaluate the effects of Zn supplementation on serum copper (Cu) to Zn and C-reactive protein (CRP) to albumin ratios (CAR) in HD patients.	Zinc	53-55	C-reactive protein	Homo sapiens	123-126
33825682-3	2021	Here, we use multiple mutational variants of SOD1 to show that the absence of Zn, and not Cu, significantly impacts membrane attachment of SOD1 through two loop regions facilitating aggregation driven by lipid induced conformational changes.	Zinc	78-80	superoxide dismutase 1	Homo sapiens	45-49
33825682-3	2021	Here, we use multiple mutational variants of SOD1 to show that the absence of Zn, and not Cu, significantly impacts membrane attachment of SOD1 through two loop regions facilitating aggregation driven by lipid induced conformational changes.	Zinc	78-80	superoxide dismutase 1	Homo sapiens	139-143
33825978-1	2021	When the resistivity of the AZO conductive layer is within the MCP resistance requirement, the interval of the Zn content is very narrow (70-73%) and difficult to control.	Zinc	111-113	CD46 molecule	Homo sapiens	63-66
33799326-1	2021	The human zinc transporter ZnT8 provides the granules of pancreatic beta-cells with zinc (II) ions for assembly of insulin hexamers for storage.	Zinc	84-93	solute carrier family 30 member 8	Homo sapiens	27-31
33799326-1	2021	The human zinc transporter ZnT8 provides the granules of pancreatic beta-cells with zinc (II) ions for assembly of insulin hexamers for storage.	Zinc	84-93	insulin	Homo sapiens	115-122
33776569-2	2021	The aim of this study was to evaluate the effects of Zn supplementation on serum copper (Cu) to Zn and C-reactive protein (CRP) to albumin ratios (CAR) in HD patients.	Zinc	53-55	albumin	Homo sapiens	131-138
33776569-9	2021	In parallel, serum albumin concentrations significantly increased, and CAR decreased in Zn supplemented group only.	Zinc	88-90	albumin	Homo sapiens	19-26
33776569-10	2021	Conclusions: Zn supplementation reduces Cu to Zn and CRP to albumin ratios in HD patients.	Zinc	13-15	C-reactive protein	Homo sapiens	53-56
33776569-10	2021	Conclusions: Zn supplementation reduces Cu to Zn and CRP to albumin ratios in HD patients.	Zinc	13-15	albumin	Homo sapiens	60-67
33799873-6	2021	At the foliar Zn site, there was 4.5% decrease in yield due to a split foliar application of 0.84 kg Zn ha-1 total, applied at V11 and V15 stage, which increased leaf Zn concentrations greater than the established toxic level.	Zinc	14-16	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	104-108
33799873-6	2021	At the foliar Zn site, there was 4.5% decrease in yield due to a split foliar application of 0.84 kg Zn ha-1 total, applied at V11 and V15 stage, which increased leaf Zn concentrations greater than the established toxic level.	Zinc	101-103	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	104-108
33236293-7	2021	Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and C-reactive Protein.	Zinc	15-17	interleukin 6	Homo sapiens	95-99
33236293-7	2021	Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and C-reactive Protein.	Zinc	15-17	C-reactive protein	Homo sapiens	151-169
25622297-6	2015	A positive correlation between Natural Resistance Associated Macrophage Protein 1 (NRAMP1) expression levels and Zn bio-concentration factors was observed.	Zinc	113-115	solute carrier family 11 member 1	Homo sapiens	31-81
32795642-2	2020	Also Zn deficiency will aggravate renal damage in diabetes through suppression of nuclear factor-erythroid 2-related factor 2 (Nrf2) expression and function.	Zinc	5-7	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-125
32795642-2	2020	Also Zn deficiency will aggravate renal damage in diabetes through suppression of nuclear factor-erythroid 2-related factor 2 (Nrf2) expression and function.	Zinc	5-7	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
32795642-7	2020	In addition, either low Zn diet or diabetes or both dramatically decreased the expression of Nrf2 and P-AKT in kidney.	Zinc	24-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
32795642-7	2020	In addition, either low Zn diet or diabetes or both dramatically decreased the expression of Nrf2 and P-AKT in kidney.	Zinc	24-26	thymoma viral proto-oncogene 1	Mus musculus	104-107
32795642-9	2020	Mechanistic study applying human renal tubular epithelial cells (HK11) confirmed the role of Nrf2, as silencing Nrf2 expression abolished Zn supplementation protection against high sugar + high fat + low Zn-induced apoptosis and downregulation of beta-catenin expression.	Zinc	138-140	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
32795642-9	2020	Mechanistic study applying human renal tubular epithelial cells (HK11) confirmed the role of Nrf2, as silencing Nrf2 expression abolished Zn supplementation protection against high sugar + high fat + low Zn-induced apoptosis and downregulation of beta-catenin expression.	Zinc	138-140	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
32795642-10	2020	All these results suggest that Nrf2 plays a key role in Zn protection against Type 2 diabetes induced renal apoptosis, which might be through Wnt/beta-catenin signaling pathway.	Zinc	56-58	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
25622297-6	2015	A positive correlation between Natural Resistance Associated Macrophage Protein 1 (NRAMP1) expression levels and Zn bio-concentration factors was observed.	Zinc	113-115	solute carrier family 11 member 1	Homo sapiens	83-89
34689109-1	2022	In this work, a rapid coprecipitation reaction is developed to obtain nano-sized Zn-doped tin oxide samples (Zn-SnO-II or Zn-SnO2-IV) for the first time by simply mixing tin ion (Sn2+ or Sn4+) and zinc ion (Zn2+) containing salts in a mild aqueous condition.	Zinc	81-83	solute carrier family 38 member 5	Homo sapiens	179-182
34653855-8	2022	Also, the existing different (Zn2+, Sn4+, and Sn2+) states helped in delaying the transfer of electron-hole recombination to obtain photocatalytic chlorophenol degradation.	Zinc	30-34	solute carrier family 38 member 5	Homo sapiens	46-49
34802930-2	2022	The present study aimed at understanding the interactions between the metal ions (Mn2+, Fe2+, Fe3+, Co2+, Cu2+, and Zn2+) and bovine serum albumin (BSA) molecules in physiological context.	Zinc	116-120	albumin	Homo sapiens	133-146
34662623-9	2022	To defend against Zn toxicity, ascorbate (AsA), glutathione (GSH), non-protein thiols (NPT) and phytochelatin (PC) content of both wheat varieties (except leaf GSH content of BN207) was increased, while, the activities of superoxide dismutase, peroxidase, catalase, ascorbate peroxidase, and the content of soluble protein decreased by 300-1000 muM Zn.	Zinc	349-351	catalase	Homo sapiens	256-264
34655499-6	2022	The released Pd(H)@ZIF-8 nanoparticles are further decomposed by gastric acid to generate zinc ions (Zn2+ ) and hydrogen, thus effectively killing H. pylori, alleviating inflammation and restoring impaired gastric mucosa simultaneously.	Zinc	101-105	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	13-24
34944467-0	2021	Mechanism of Zn2+ and Ca2+ Binding to Human S100A1.	Zinc	13-17	S100 calcium binding protein A1	Homo sapiens	44-50
34212467-0	2022	Influence of bovine serum albumin on biodegradation behavior of pure Zn.	Zinc	69-71	albumin	Homo sapiens	20-33
34212467-2	2022	In this work, we investigate the influence of bovine serum albumin (BSA)-the most abundant blood protein in simulated body fluid (SBF) on degradation of pure Zn via electrochemical measurements and long-term immersion.	Zinc	158-160	albumin	Homo sapiens	53-66
34333009-11	2022	Combination use of P (25 kg ha-1) and Zn fertilizer on maize enhanced its nutritional supply ability regarding Zn and Cu, and simultaneously mitigated potential human health risks associated with Cd and Pb.	Zinc	111-113	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	28-32
34924116-4	2022	Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism.	Zinc	153-155	solute carrier family 30 member 10	Homo sapiens	223-228
34793899-1	2022	On the basis of amyloid beta (Abeta) peptides as triggers in atrophy of structures in the limbic system, here we postulated that Abeta1-42-induced intracellular Zn2+ toxicity in the basolateral amygdala contributes to conditioned fear memory.	Zinc	161-165	amyloid beta precursor protein	Homo sapiens	16-28
34793899-1	2022	On the basis of amyloid beta (Abeta) peptides as triggers in atrophy of structures in the limbic system, here we postulated that Abeta1-42-induced intracellular Zn2+ toxicity in the basolateral amygdala contributes to conditioned fear memory.	Zinc	161-165	amyloid beta precursor protein	Homo sapiens	30-35
34927377-7	2022	Further studies conclude that the improved activity of electrocatalytic NO 3 - reduction was ascribed to the existence of abundant active sites and the charge transfer from Co atoms to Zn atoms after Zn doping.	Zinc	185-187	NBL1, DAN family BMP antagonist	Homo sapiens	72-76
34927377-7	2022	Further studies conclude that the improved activity of electrocatalytic NO 3 - reduction was ascribed to the existence of abundant active sites and the charge transfer from Co atoms to Zn atoms after Zn doping.	Zinc	200-202	NBL1, DAN family BMP antagonist	Homo sapiens	72-76
34817990-3	2021	It has been recently reported that Zn2+ interacts with Abeta and changes its aggregation pathway away from less harmful fibrillar forms to more toxic species.	Zinc	35-39	amyloid beta precursor protein	Homo sapiens	55-60
34890370-6	2021	In women with a normal BMI, the levels of IL-1beta significantly positively correlated with Ca and Sr, and CRP positively correlated with Zn.	Zinc	138-140	C-reactive protein	Homo sapiens	107-110
34890370-8	2021	In obese women, the levels of CRP positively correlated with Zn, TNFalpha with Mg, IFNgamma with Cu and P.	Zinc	61-63	C-reactive protein	Homo sapiens	30-33
34944467-3	2021	S100A1 has also been shown to bind Zn2+, but the molecular mechanisms of this binding are not yet known.	Zinc	35-39	S100 calcium binding protein A1	Homo sapiens	0-6
34944467-5	2021	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	55-59	S100 calcium binding protein A1	Homo sapiens	168-174
34944467-5	2021	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	106-110	S100 calcium binding protein A1	Homo sapiens	168-174
34944467-6	2021	In addition, two lower affinity sites can bind Zn2+ even when the EF-hands are saturated by Ca2+, resulting in a 2Ca2+:S100A1:2Zn2+ conformer.	Zinc	47-51	S100 calcium binding protein A1	Homo sapiens	119-125
34944467-7	2021	Finally, we show that, in contrast to calcium, an excess of Zn2+ produces a destabilizing effect on S100A1 structure and leads to its aggregation.	Zinc	60-64	S100 calcium binding protein A1	Homo sapiens	100-106
34944467-8	2021	We also determined a higher affinity to Ca2+ (KD~0.16 and 24 mum) than was previously reported for S100A1, which would allow this protein to function as a Ca2+/Zn2+-sensor both inside and outside cells, participating in diverse signaling pathways under normal and pathological conditions.	Zinc	160-164	S100 calcium binding protein A1	Homo sapiens	99-105
34988394-1	2021	We study the interaction between amyloid beta (Abeta) peptides and Cu and Zn metal ions by using soft X-ray absorption spectroscopy.	Zinc	74-76	amyloid beta precursor protein	Homo sapiens	33-45
34725844-0	2021	Fatty acids may influence insulin dynamics through modulation of albumin-Zn2+ interactions.	Zinc	73-77	insulin	Homo sapiens	26-33
34844514-1	2021	Two structurally similar derivatives of chlorophyll a, chlorophyllide a (Chlide) and zinc-pheophorbide a (Zn-Pheide), differing only in central metal ion (Mg2+ or Zn2+, respectively) substituting the tetrapyrrole ring, were investigated with regard to their binding to human serum albumin (HSA).	Zinc	163-167	albumin	Homo sapiens	275-288
34725844-1	2021	Insulin is stored within the pancreas in an inactive Zn2+ -bound hexameric form prior to release.	Zinc	53-57	insulin	Homo sapiens	0-7
34725844-3	2021	Upon release from the pancreas or upon injection, insulin only becomes active once Zn2+ disengages from the complex.	Zinc	83-87	insulin	Homo sapiens	50-57
34725844-4	2021	In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+ .	Zinc	58-62	albumin	Homo sapiens	81-94
34725844-4	2021	In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+ .	Zinc	58-62	insulin	Homo sapiens	142-149
34725844-4	2021	In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+ .	Zinc	190-194	albumin	Homo sapiens	81-94
34725844-4	2021	In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+ .	Zinc	190-194	insulin	Homo sapiens	142-149
34725844-7	2021	Here we present the hypothesis that higher NEFA levels in obese and/or diabetic individuals may contribute to insulin resistance and affect therapeutic insulin dose-response profiles, through modulation of HSA/Zn2+ dynamics.	Zinc	210-214	insulin	Homo sapiens	110-117
34725844-7	2021	Here we present the hypothesis that higher NEFA levels in obese and/or diabetic individuals may contribute to insulin resistance and affect therapeutic insulin dose-response profiles, through modulation of HSA/Zn2+ dynamics.	Zinc	210-214	insulin	Homo sapiens	152-159
34510667-9	2021	RESULTS: Pooled-analysis of 18 studies showed that Zn supplementation improved MDA and Hcys levels (SMD= -1.53 mumol/L; 95% CI: -2.22, -0.85; P< 0.001 and SMD= -0.62 mumol/L; 95% CI: -1.08, -0.15; P< 0.001, respectively).	Zinc	51-53	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	100-104
34510667-9	2021	RESULTS: Pooled-analysis of 18 studies showed that Zn supplementation improved MDA and Hcys levels (SMD= -1.53 mumol/L; 95% CI: -2.22, -0.85; P< 0.001 and SMD= -0.62 mumol/L; 95% CI: -1.08, -0.15; P< 0.001, respectively).	Zinc	51-53	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	155-159
34298330-14	2021	Age was a major factor associated with both Zn and Cu deficiencies.	Zinc	44-46	renin binding protein	Homo sapiens	0-3
34788624-5	2021	We show that Nudt3 shifts its substrate specificity depending on the cation; specifically, Nudt3 is active on polyP when Zn2+ is present.	Zinc	121-125	nudix hydrolase 3	Homo sapiens	13-18
34788624-5	2021	We show that Nudt3 shifts its substrate specificity depending on the cation; specifically, Nudt3 is active on polyP when Zn2+ is present.	Zinc	121-125	nudix hydrolase 3	Homo sapiens	91-96
34988394-1	2021	We study the interaction between amyloid beta (Abeta) peptides and Cu and Zn metal ions by using soft X-ray absorption spectroscopy.	Zinc	74-76	amyloid beta precursor protein	Homo sapiens	47-52
34702529-5	2021	In vivo wound healing studies on rats for 21 days proves that ZnG/rhEGF@Chit/Polo supplements the requisite Zn2+ and rhEGF for wound healing to promote the vascular remodeling and collagen deposition, facilitate fibrogenesis, and reduce the level of interleukin 6 for wound basement repair, and thus is a good wound therapy.	Zinc	108-112	interleukin 6	Rattus norvegicus	250-263
34836302-7	2021	As compared to the NGT group, serum Cu concentration was highest in the AGT group (p = 0.03), serum Se concentration was highest in the DM group (p < 0.0001), and serum Zn concentration was highest in the AGT group (p < 0.0001).	Zinc	169-171	angiotensinogen	Homo sapiens	205-208
34750356-2	2021	Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.	Zinc	6-10	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	30-33
34750356-9	2021	Finally, dietary Zn2+ deficiency in mice resulted in decreased striatal Zn2+ content, cocaine locomotor sensitization, CPP, and striatal DAT binding.	Zinc	17-21	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	137-140
34867993-5	2021	Mechanistically, MT3 increased intramacrophage Zn2+ to downmodulate the TRIF-IRF3-STAT1 axis that is prerequisite for caspase-11 effector function.	Zinc	47-51	TIR domain containing adaptor molecule 1	Homo sapiens	72-76
34831318-4	2021	In SH-SY5Y cells expressing the GFP-tagged Abeta-folding reporter, both ZN compounds reduced Abeta aggregation, oxidative stress, activities of caspase-1 and AChE, as well as increased neurite outgrowth.	Zinc	72-74	amyloid beta precursor protein	Homo sapiens	43-48
34831318-4	2021	In SH-SY5Y cells expressing the GFP-tagged Abeta-folding reporter, both ZN compounds reduced Abeta aggregation, oxidative stress, activities of caspase-1 and AChE, as well as increased neurite outgrowth.	Zinc	72-74	caspase 1	Homo sapiens	144-153
34831318-4	2021	In SH-SY5Y cells expressing the GFP-tagged Abeta-folding reporter, both ZN compounds reduced Abeta aggregation, oxidative stress, activities of caspase-1 and AChE, as well as increased neurite outgrowth.	Zinc	72-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-162
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	mitogen-activated protein kinase 1	Homo sapiens	28-65
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	mitogen-activated protein kinase 1	Homo sapiens	67-70
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	AKT serine/threonine kinase 1	Homo sapiens	76-105
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	AKT serine/threonine kinase 1	Homo sapiens	107-110
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	BCL2 apoptosis regulator	Homo sapiens	255-272
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	BCL2 apoptosis regulator	Homo sapiens	274-278
34197819-1	2021	In this study, a novel electrochemical sensor for simultaneous detection of Pb(II) and Cu(II) was constructed by using Zn/Ni-ZIF-8/XC-72/Nafion hybrid material as electrode surface modifier.	Zinc	119-121	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-93
34197819-4	2021	In addition, the effects of various conditions including pH, the type of buffer and the ratio of Zn/Ni-ZIF-8 to XC-72 were also explored for the determination of Pb(II) and Cu(II).	Zinc	97-99	submaxillary gland androgen regulated protein 3B	Homo sapiens	162-179
34707296-4	2021	The cryo-electron microscopy structure reveals domain organization and structural details of the Nf1 exon 23a splicing3 isoform 2 in a closed, self-inhibited, Zn-stabilized state and an open state.	Zinc	159-161	neurofibromin 1	Homo sapiens	97-100
34707296-7	2021	Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD-Sec14-PH linker.	Zinc	0-2	neurofibromin 1	Homo sapiens	17-20
34707296-7	2021	Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD-Sec14-PH linker.	Zinc	134-136	neurofibromin 1	Homo sapiens	17-20
34668076-7	2021	The calibration curve showed a linear range of 1 to 70 microg L-1 and 1 to 70 micromol L-1 for Zn2+ and UA, respectively.	Zinc	95-99	L1 cell adhesion molecule	Homo sapiens	62-71
34708332-5	2021	Mean body weight, serum concentrations of C-reactive protein, neuropeptide-Y, leptin, insulin fasting blood glucose, and HOMA-IR were statistically decreased by given Zn in HFD + obese + Zn group compared to HFD + obese rats.	Zinc	167-169	C-reactive protein	Rattus norvegicus	42-60
34708332-5	2021	Mean body weight, serum concentrations of C-reactive protein, neuropeptide-Y, leptin, insulin fasting blood glucose, and HOMA-IR were statistically decreased by given Zn in HFD + obese + Zn group compared to HFD + obese rats.	Zinc	167-169	neuropeptide Y	Rattus norvegicus	62-76
34686032-8	2021	Catalase activity was shown to be less sensitive to Zn treatment and was only induced in var.	Zinc	52-54	catalase	Homo sapiens	0-8
34161632-8	2021	A candidate gene association analysis further verified that GRMZM2G142870 and GRMZM2G045531 affect Zn and Mn accumulations, respectively.	Zinc	99-101	ABC transporter C family member 14	Zea mays	60-73
34559918-9	2021	Our data demonstrate that IRT3, ZIP4, ZIP6 and ZIP9 function redundantly in maintaining Zn homeostasis and seed development in A. thaliana.	Zinc	88-90	ZIP metal ion transporter family	Arabidopsis thaliana	38-42
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	integrin, alpha 10	Mus musculus	165-171
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	integrin, alpha 10	Mus musculus	191-197
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	thymoma viral proto-oncogene 1	Mus musculus	212-215
34687486-4	2022	The cell parameters of Zn-HAp nanoparticles decreased with increasing of Zn content in the HAp structures.	Zinc	23-25	hemaglutinin-associated protein	Escherichia coli	26-29
34687486-4	2022	The cell parameters of Zn-HAp nanoparticles decreased with increasing of Zn content in the HAp structures.	Zinc	23-25	hemaglutinin-associated protein	Escherichia coli	91-94
34687486-4	2022	The cell parameters of Zn-HAp nanoparticles decreased with increasing of Zn content in the HAp structures.	Zinc	73-75	hemaglutinin-associated protein	Escherichia coli	26-29
34687486-4	2022	The cell parameters of Zn-HAp nanoparticles decreased with increasing of Zn content in the HAp structures.	Zinc	73-75	hemaglutinin-associated protein	Escherichia coli	91-94
34687486-5	2022	This tendency implies that Zn ions substituted for Ca sites in the HAp crystal lattices.	Zinc	27-29	hemaglutinin-associated protein	Escherichia coli	67-70
34687486-6	2022	To investigate the biological effects of Zn-HAp nanoparticles, cell proliferation activity of MC3T3-E1 osteoblasts and antibacterial activity against Escherichia coli were evaluated in vitro.	Zinc	41-43	hemaglutinin-associated protein	Escherichia coli	44-47
34687486-7	2022	According to the results obtained, Zn-HAp nanoparticles containing of 14.7% Zn ions was noticeable shown shareability of the conflicting activities at 0.1 mg/mL.	Zinc	35-37	hemaglutinin-associated protein	Escherichia coli	38-41
34687486-7	2022	According to the results obtained, Zn-HAp nanoparticles containing of 14.7% Zn ions was noticeable shown shareability of the conflicting activities at 0.1 mg/mL.	Zinc	76-78	hemaglutinin-associated protein	Escherichia coli	38-41
34668076-9	2021	The detection limits for Zn2+ and UA were 0.10 microg L-1 and 0.28 micromol L-1, respectively.	Zinc	25-29	L1 cell adhesion molecule	Homo sapiens	54-63
34683739-1	2021	This article discusses the properties of as many as 30 carbene-ZnX2 (X = H, Me, Et) complexes featuring a zinc bond C Zn.	Zinc	118-120	major facilitator superfamily domain containing 11	Homo sapiens	80-82
34712389-9	2021	Breeder plasma Zn concentration and erythrocytic 5"-NT activities at week 6 were positively correlated with GSH-Px activity and GPx, MT1, and BCL2 mRNA expressions in embryonic livers on E29.	Zinc	15-17	BCL2 apoptosis regulator	Homo sapiens	142-146
34722456-5	2021	Separation of mixed minerals of smithsonite and quartz using a PNP collector provides the optimum concentrate index (Zn grade 50.84% and Zn recovery 85.36%).	Zinc	137-139	purine nucleoside phosphorylase	Homo sapiens	63-66
34236090-1	2021	The excitation energies, singlet-triplet energy gap and spin-orbit coupling constants for Zn-, GaCl-, Pd-, and Pt- tetrasulfonyl phthalocyanines complexes (ZnPc, GaClPc, PdPc, and PtPc) have been computed by using the density functional theory and employing the M06 exchange-correlation functional.	Zinc	90-92	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	170-174
34514483-4	2021	We present the first crystal structure of the Mpro-Zn2+ complex at 1.9 A and provide the structural basis of viral replication inhibition.	Zinc	51-55	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	46-50
34514483-5	2021	We show that Zn2+ coordinates with the catalytic dyad at the enzyme active site along with two previously unknown water molecules in a tetrahedral geometry to form a stable inhibited Mpro-Zn2+ complex.	Zinc	13-17	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
34514483-5	2021	We show that Zn2+ coordinates with the catalytic dyad at the enzyme active site along with two previously unknown water molecules in a tetrahedral geometry to form a stable inhibited Mpro-Zn2+ complex.	Zinc	188-192	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
34514483-7	2021	As the catalytic dyad is highly conserved across SARS-CoV, MERS-CoV and all variants of SARS-CoV-2, Zn2+ mediated inhibition of Mpro may have wider implications.	Zinc	100-104	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	128-132
34384998-7	2021	Using a molecular dynamic simulation approach, we identified the N2, methyl of C1 and benzene ring of harmine interact with Zn2+ (2.4 A), His205 (2.4 A) and His211 (2.4 A) as well as Val163 (2.7 A) at the active site of MMP-3, respectively, and thus conferred a striking specific binding advantage.	Zinc	124-128	matrix metallopeptidase 3	Homo sapiens	220-225
34498162-5	2021	RESULTS: Serum Cu levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in the group of CRC patient carrying the GA heterozygous genotype of the GSTM1 (rs 112,778,559) gene variation compared to healthy controls (p < 0.05).	Zinc	51-53	glutathione S-transferase mu 1	Homo sapiens	170-175
34498162-6	2021	Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in patients carrying GG homozygous genotype of the GSTM1 (rs 112778559) gene variation compared to healthy controls carrying same genotype (p < 0.05).	Zinc	10-12	glutathione S-transferase mu 1	Homo sapiens	143-148
34498162-6	2021	Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in patients carrying GG homozygous genotype of the GSTM1 (rs 112778559) gene variation compared to healthy controls carrying same genotype (p < 0.05).	Zinc	46-48	glutathione S-transferase mu 1	Homo sapiens	143-148
34498162-7	2021	Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in the group of CRC patient carrying the GG homozygous genotype of the GSTM1 (rs 12068997) gene variation compared to healthy controls (p < 0.05).	Zinc	10-12	glutathione S-transferase mu 1	Homo sapiens	163-168
34498162-7	2021	Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in the group of CRC patient carrying the GG homozygous genotype of the GSTM1 (rs 12068997) gene variation compared to healthy controls (p < 0.05).	Zinc	46-48	glutathione S-transferase mu 1	Homo sapiens	163-168
34683825-6	2021	This cytoplasmic Zn enhancement would be probably associated with the upregulation of several Zn influx membrane transporters (Zips) and could explain the amelioration in the glycaemia and insulinaemia by upregulating the Akt and downregulating the inhibitor PTP1B, in obese and diabetic conditions.	Zinc	17-19	AKT serine/threonine kinase 1	Rattus norvegicus	222-225
34558100-12	2021	Effects of Cu2+ and Zn2+ ions in the degradation of human and murine IAPP by insulin-degrading enzyme were studied by liquid chromatography/mass spectrometry (LC/MS).	Zinc	20-24	islet amyloid polypeptide	Mus musculus	69-73
34558100-12	2021	Effects of Cu2+ and Zn2+ ions in the degradation of human and murine IAPP by insulin-degrading enzyme were studied by liquid chromatography/mass spectrometry (LC/MS).	Zinc	20-24	insulin degrading enzyme	Mus musculus	77-101
34631763-13	2021	Serum Cu/Zn ratio was high, (2.76 +- 0.68), directly and significantly associated with HD period, CRP, BMI, VFA, and inversely with Kt/V, albumin, iron, and iPTH.	Zinc	9-11	C-reactive protein	Homo sapiens	98-101
34683825-6	2021	This cytoplasmic Zn enhancement would be probably associated with the upregulation of several Zn influx membrane transporters (Zips) and could explain the amelioration in the glycaemia and insulinaemia by upregulating the Akt and downregulating the inhibitor PTP1B, in obese and diabetic conditions.	Zinc	17-19	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	259-264
34901539-8	2022	Whereas the direct stimulating effects on BMSCs by Zn2+/Sr2+ were more effectively at the later stage with Nfatc1/Maf and Wnt signals activated.	Zinc	51-55	MAF bZIP transcription factor	Homo sapiens	114-117
34576303-7	2021	Zn2+ is a potent regulator of coagulation and its availability in the plasma is monitored carefully through buffering by human serum albumin (HSA).	Zinc	0-4	albumin	Homo sapiens	127-140
34291545-3	2021	This reaction enables the formation of two new C(sp 3 )-C(sp 2 ) bonds using a bench-stable Ni/bipyridine/Zn system featuring a broad substrate scope and excellent diastereoselectivity, which provides an effective platform for the remote aryl group migration and arylation of amino acid esters via redox-neutral C(sp 3 )-C(sp 2 ) bond cleavage.	Zinc	106-108	Sp2 transcription factor	Homo sapiens	56-62
34291545-3	2021	This reaction enables the formation of two new C(sp 3 )-C(sp 2 ) bonds using a bench-stable Ni/bipyridine/Zn system featuring a broad substrate scope and excellent diastereoselectivity, which provides an effective platform for the remote aryl group migration and arylation of amino acid esters via redox-neutral C(sp 3 )-C(sp 2 ) bond cleavage.	Zinc	106-108	Sp2 transcription factor	Homo sapiens	321-327
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
34102185-14	2021	Zn had ameliorative effects on superoxide dismutase (SOD) activity after elimination of publication bias (SMD: 0.84 U/g; 95% CI: 0.12, 1.56, P<0.05).	Zinc	0-2	superoxide dismutase 1	Homo sapiens	31-51
34102185-14	2021	Zn had ameliorative effects on superoxide dismutase (SOD) activity after elimination of publication bias (SMD: 0.84 U/g; 95% CI: 0.12, 1.56, P<0.05).	Zinc	0-2	superoxide dismutase 1	Homo sapiens	53-56
34102185-15	2021	Zn could also elevate GSH and TAC levels, plus SOD activity after modifying the publication bias.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	47-50
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-146
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	AKT serine/threonine kinase 1	Rattus norvegicus	148-151
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	sirtuin 1	Rattus norvegicus	175-180
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	sirtuin 1	Rattus norvegicus	152-157
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
34062438-8	2021	In particular, the level of zip4 was influenced by Zn exposure regardless of the exposure routes, while changes in zip7 and zip8 levels were predominantly driven by waterborne exposure.	Zinc	51-53	solute carrier family 39 member 4	Danio rerio	28-32
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Zinc	47-51	membrane metalloendopeptidase	Homo sapiens	38-41
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Zinc	47-51	amyloid beta precursor protein	Homo sapiens	55-60
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Zinc	47-51	amyloid beta precursor protein	Homo sapiens	100-105
34343891-12	2021	The molecular docking and MD simulation results revealed that the active site residue Glu-538 of bacterial NEP along with Zn2+ interact with His-13 of Abeta peptide.	Zinc	122-126	membrane metalloendopeptidase	Homo sapiens	107-110
34343891-12	2021	The molecular docking and MD simulation results revealed that the active site residue Glu-538 of bacterial NEP along with Zn2+ interact with His-13 of Abeta peptide.	Zinc	122-126	amyloid beta precursor protein	Homo sapiens	151-156
34479494-13	2021	Spearman correlation analysis showed a significant negative association between serum Zn, Se and CRP level (r = - 0.35, P-value = 0.001 for Se; r = - 0.41, P-value < 0.001 for Zn).	Zinc	86-88	C-reactive protein	Homo sapiens	97-100
34479494-13	2021	Spearman correlation analysis showed a significant negative association between serum Zn, Se and CRP level (r = - 0.35, P-value = 0.001 for Se; r = - 0.41, P-value < 0.001 for Zn).	Zinc	176-178	C-reactive protein	Homo sapiens	97-100
34479494-14	2021	CONCLUSION: Results suggest that increasing levels of Se and Zn were accompanied by a decrease in serum CRP level.	Zinc	61-63	C-reactive protein	Homo sapiens	104-107
34433664-0	2021	SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health.	Zinc	25-29	solute carrier family 30 member 9	Homo sapiens	0-8
34338604-9	2021	Our results show that Zn could prevent Cd-induced toxicity on MC3T3-E1 cells, probably through the restoration of Runx2, col alpha1, BSP, ALP and Oc and gene expression inhibited by Cd.	Zinc	22-24	collagen, type I, alpha 1	Mus musculus	121-131
34433664-0	2021	SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health.	Zinc	43-47	solute carrier family 30 member 9	Homo sapiens	0-8
34433664-4	2021	Here, we find that the SLC-30A9 transporter localizes on mitochondria and is required for export of Zn2+ from mitochondria in both Caenorhabditis elegans and human cells.	Zinc	100-104	solute carrier family 30 member 9	Homo sapiens	23-31
34433664-5	2021	Loss of slc-30a9 leads to elevated Zn2+ levels in mitochondria, a severely swollen mitochondrial matrix in many tissues, compromised mitochondrial metabolic function, reductive stress, and induction of the mitochondrial stress response.	Zinc	35-39	solute carrier family 30 member 9	Homo sapiens	8-16
34433664-6	2021	SLC-30A9 is also essential for organismal fertility and sperm activation in C. elegans, during which Zn2+ exits from mitochondria and acts as an activation signal.	Zinc	101-105	solute carrier family 30 member 9	Homo sapiens	0-8
34447788-0	2021	Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy.	Zinc	25-27	protein kinase C alpha	Homo sapiens	60-63
34429510-0	2021	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions.	Zinc	82-86	toll like receptor 1	Homo sapiens	14-34
34429510-4	2021	We found that the TLR1-TIR domain is capable of specific binding of Zn with nanomolar affinity.	Zinc	68-70	toll like receptor 1	Homo sapiens	18-22
34429510-7	2021	Using the functional assays for the heterodimeric TLR1/2 receptor, we found that both Zn addition and Zn depletion affect the activity of TLR1, and C667A mutation disrupts the receptor activity.	Zinc	86-88	toll like receptor 1	Homo sapiens	138-142
34429510-7	2021	Using the functional assays for the heterodimeric TLR1/2 receptor, we found that both Zn addition and Zn depletion affect the activity of TLR1, and C667A mutation disrupts the receptor activity.	Zinc	102-104	toll like receptor 1	Homo sapiens	138-142
34348022-6	2021	We found that Cu and Zn were bound to SOD1 in a ratio of 1.12 +- 0.28, a ratio very close to the expected value of 1.	Zinc	21-23	superoxide dismutase 1	Homo sapiens	38-42
34225168-3	2021	The model system of hCA VII included the core catalytic center, the Zn2+ ion, its three histidine ligands and a hydroxide ion or water molecule coordinated to it.	Zinc	68-72	carbonic anhydrase 7	Homo sapiens	20-27
34369509-4	2021	Typically, HDAC2 inhibitors interact with the Zn2+ ions through the core chelate group, while HDAC8 inhibitors adopt a bent conformation within the HDAC8 pocket that inclines to be in contact with the Zn2+ ions through the terminal hydroxamic acid group.	Zinc	46-50	histone deacetylase 2	Homo sapiens	11-16
34406479-0	2021	Influence of bovine serum albumin on corrosion behaviour of pure Zn in phosphate buffered saline.	Zinc	65-67	albumin	Homo sapiens	20-33
34162214-6	2021	MFRMs redistribute zinc from neurotoxic amyloid beta zinc (Abeta:Zn) complexes to the cytoplasm facilitating the degradation of Abeta plaques by MMP-2.	Zinc	65-67	amyloid beta precursor protein	Homo sapiens	40-52
34162214-6	2021	MFRMs redistribute zinc from neurotoxic amyloid beta zinc (Abeta:Zn) complexes to the cytoplasm facilitating the degradation of Abeta plaques by MMP-2.	Zinc	65-67	amyloid beta precursor protein	Homo sapiens	59-64
34162214-6	2021	MFRMs redistribute zinc from neurotoxic amyloid beta zinc (Abeta:Zn) complexes to the cytoplasm facilitating the degradation of Abeta plaques by MMP-2.	Zinc	65-67	amyloid beta precursor protein	Homo sapiens	128-133
34313127-4	2021	In the presence of redox-inactive metal ions such as Zn2+, La3+, Lu3+, and Y3+, the reaction does not form the hydroximatocobalt(III) complex but instead gives peroxyimidatocobalt(III) complexes, (CoIII(TBDAP)(R-C( NH)O2))2+ (R = Me (2) and Ph (2Ph)).	Zinc	53-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	197-202
34254979-2	2021	Structural studies of YiiP from prokaryotes and Znt8 from humans have revealed three different Zn2+ sites and a conserved homodimeric architecture.	Zinc	95-99	solute carrier family 30 member 8	Homo sapiens	48-52
34307302-3	2021	Prior to CO2 hydration, the proton transfer from the water molecule (WT1) to H64 is the rate-limiting step with the free energy barrier of 10.4 kcal/mol, which leads to the ready state with the Zn-bound OH-.	Zinc	194-196	WT1 transcription factor	Homo sapiens	69-72
34181945-5	2021	We investigated the kinetics of MBL inactivation in detail and report that AMA is a selective Zn2+ scavenger that indirectly inactivates NDM-1 by encouraging the dissociation of a metal cofactor.	Zinc	94-98	mannose-binding lectin family member 3, pseudogene	Homo sapiens	32-35
34181945-9	2021	These results indicate that the mechanism of AMA is broadly applicable to diverse Zn2+ chelators, and highlight that leveraging Zn2+ availability can influence the survival of MBL-producing bacteria when they are exposed beta-lactam antibiotics.	Zinc	82-86	mannose-binding lectin family member 3, pseudogene	Homo sapiens	176-179
34181945-9	2021	These results indicate that the mechanism of AMA is broadly applicable to diverse Zn2+ chelators, and highlight that leveraging Zn2+ availability can influence the survival of MBL-producing bacteria when they are exposed beta-lactam antibiotics.	Zinc	128-132	mannose-binding lectin family member 3, pseudogene	Homo sapiens	176-179
34062038-4	2021	Mechanism studies indicate that the accompanying Zn 2+ generated from zinc reduction of the Co II complex plays a critical role to initiate a plausible Co I /Co III catalytic cycle.	Zinc	49-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
34062038-4	2021	Mechanism studies indicate that the accompanying Zn 2+ generated from zinc reduction of the Co II complex plays a critical role to initiate a plausible Co I /Co III catalytic cycle.	Zinc	49-51	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-164
34357910-4	2021	PM2.5 and TSP contained high concentrations of heavy metals (Cu, Fe, Zn, and Pb).	Zinc	69-71	thrombospondin 1	Homo sapiens	10-13
34247649-5	2021	We further confirmed that induction of M2 polarization by Zn2+ was realized via PI3K/Akt/mTOR pathway, whereas marker molecules on this pathway were strictly regulated by the addition of Zn2+.	Zinc	58-62	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
34174567-7	2021	Inclusion of 80 and 100 mg/kg Zn as ZH tended to upregulate the expression of claudin-1 (P = 0.088) and tight junction protein-1 (P = 0.086).	Zinc	30-32	claudin 1	Gallus gallus	78-87
34196493-4	2021	In addition, Cu dopant helps to balance the positive charge at Zn dopant resulting from low pH, enabling CuZn-CDs to still process CAT ability rather than peroxidase ability.	Zinc	63-65	catalase	Homo sapiens	131-134
34188447-9	2021	Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays.	Zinc	56-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-169
34212656-8	2021	The loadings of Zn were 4.83 kg a-1 and 3.21 kg a-1 in Wuxi and Nanjing, respectively.	Zinc	16-18	BCL2 related protein A1	Homo sapiens	32-41
34161364-10	2021	Grain yield of different genotypes ranged from 439 to 904 kg ha-1 under control and 536 to 1462 kg ha-1 under Zn-fertilization.	Zinc	110-112	Rho GTPase activating protein 45	Homo sapiens	99-103
34188447-9	2021	Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays.	Zinc	56-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-175
34200394-7	2021	In turn, Zn2+ added to Biolasol + PRL (PRL: 0.1 microg/L) acted as a prolactin inhibitor.	Zinc	9-13	prolactin	Homo sapiens	34-37
34400875-10	2021	The expression of IL-1beta and TNF-alpha was also reduced to a greater degree in the SAP + Zn group than in the SAP group.	Zinc	91-93	interleukin 1 alpha	Rattus norvegicus	18-26
34400875-10	2021	The expression of IL-1beta and TNF-alpha was also reduced to a greater degree in the SAP + Zn group than in the SAP group.	Zinc	91-93	tumor necrosis factor	Rattus norvegicus	31-40
34400875-13	2021	Zn supplementation prevented the release of TNF-alpha and IL-1beta, alleviated intestinal permeability and endotoxemia, reduced bacterial translocation, and inhibited changes in pathogenic intestinal flora in rats with SAP.	Zinc	0-2	tumor necrosis factor	Rattus norvegicus	44-53
34400875-13	2021	Zn supplementation prevented the release of TNF-alpha and IL-1beta, alleviated intestinal permeability and endotoxemia, reduced bacterial translocation, and inhibited changes in pathogenic intestinal flora in rats with SAP.	Zinc	0-2	interleukin 1 alpha	Rattus norvegicus	58-66
34200394-7	2021	In turn, Zn2+ added to Biolasol + PRL (PRL: 0.1 microg/L) acted as a prolactin inhibitor.	Zinc	9-13	prolactin	Homo sapiens	39-56
34200394-7	2021	In turn, Zn2+ added to Biolasol + PRL (PRL: 0.1 microg/L) acted as a prolactin inhibitor.	Zinc	9-13	prolactin	Homo sapiens	69-78
34122330-4	2021	Additionally, we highlight the role of zinc(II) ions in the paracrine signaling of the endocrine pancreas via serological measurements of insulin and c-peptide.	Zinc	39-47	insulin	Homo sapiens	150-159
34199478-0	2021	Comparison of Physicochemical Properties of Fly Ash Precursor, Na-P1(C) Zeolite-Carbon Composite and Na-P1 Zeolite-Adsorption Affinity to Divalent Pb and Zn Cations.	Zinc	154-156	Nucleosome assembly protein 1	Drosophila melanogaster	101-106
34072023-5	2021	A Zn concentration was especially decreased in the blood of smoking AP patients with the AA genotype for SNP rs11640851 in the MT1A gene and the GC genotype for SNP rs10636 in MT2A, compared to non-smokers with AP, which was accompanied by an increase in the value of the Cu/Zn ratio.	Zinc	2-4	metallothionein 1A	Homo sapiens	127-131
34122330-6	2021	Contrast enhancement of the pancreas resulting from co-release of zinc(II) ion with insulin was observed focally when using the zinc(II)-specific agent, Gd-CP027, whereas little enhancement was detected when using gadofosveset.	Zinc	128-136	insulin	Homo sapiens	84-91
35623885-6	2022	Blockade of the primary route for Zn2+ entry, the mitochondrial Ca2+ uniporter (MCU; with ruthenium red, RR) or Zn2+ chelation shortly after OGD withdrawal substantially attenuated the mitochondrial depolarization and the changes in synaptic activity.	Zinc	34-38	carbonic anhydrase 2	Rattus norvegicus	64-67
34163679-2	2021	In plasma, the free Zn2+ concentration is fine-tuned through buffering by human serum albumin (HSA).	Zinc	20-24	albumin	Homo sapiens	80-93
35634784-0	2022	The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn2+ -binding domain essential for structural integrity and channel activity.	Zinc	65-69	transient receptor potential cation channel, subfamily M, member 2	Danio rerio	25-30
35634784-6	2022	In combination with patch clamp experiments we comprehensively characterize the effect of the Zn2+ -binding domain on TRPM2 activation.	Zinc	94-98	transient receptor potential cation channel, subfamily M, member 2	Danio rerio	118-123
34553578-6	2021	RESULTS: A significant increase in the concentrations of VEGF and trace elements Mg, Mn, Cu, Zn, and Se in the blood serum of patients with ischemic stroke was revealed.	Zinc	93-95	vascular endothelial growth factor A	Homo sapiens	57-61
35487360-7	2022	Therefore, a quantitative structure-activity relationship (QSAR) model was constructed to characterize the binding constants (Ka) between DNA binding domain of p53 (p53 DBD) and nine metal ions (Mg2+, Ca2+, Cu2+, Zn2+, Co2+, Ni2+, Mn2+, Fe3+ and Ba2+).	Zinc	213-217	tumor protein p53	Homo sapiens	160-163
35487360-7	2022	Therefore, a quantitative structure-activity relationship (QSAR) model was constructed to characterize the binding constants (Ka) between DNA binding domain of p53 (p53 DBD) and nine metal ions (Mg2+, Ca2+, Cu2+, Zn2+, Co2+, Ni2+, Mn2+, Fe3+ and Ba2+).	Zinc	213-217	tumor protein p53	Homo sapiens	165-168
35476313-4	2022	Zn reduced the motor activities, the number of tyrosine hydroxylase (TH)-positive neurons, and level of TH protein.	Zinc	0-2	tyrosine hydroxylase	Homo sapiens	47-67
35476313-4	2022	Zn reduced the motor activities, the number of tyrosine hydroxylase (TH)-positive neurons, and level of TH protein.	Zinc	0-2	tyrosine hydroxylase	Homo sapiens	69-71
35476313-4	2022	Zn reduced the motor activities, the number of tyrosine hydroxylase (TH)-positive neurons, and level of TH protein.	Zinc	0-2	tyrosine hydroxylase	Homo sapiens	104-106
35476313-5	2022	Conversely, Zn increased the mitochondrial reactive oxygen species (ROS) production, lipid peroxidation (LPO), and superoxide dismutase (SOD) activity and reduced the mitochondrial membrane potential and catalytic activities of complex I and III.	Zinc	12-14	superoxide dismutase 1	Homo sapiens	115-135
35476313-5	2022	Conversely, Zn increased the mitochondrial reactive oxygen species (ROS) production, lipid peroxidation (LPO), and superoxide dismutase (SOD) activity and reduced the mitochondrial membrane potential and catalytic activities of complex I and III.	Zinc	12-14	superoxide dismutase 1	Homo sapiens	137-140
35630637-0	2022	Evaluation of Zn2+- and Cu2+-Binding Affinities of Native Cu,Zn-SOD1 and Its G93A Mutant by LC-ICP MS.	Zinc	14-18	superoxide dismutase 1	Homo sapiens	64-68
35630637-1	2022	The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS).	Zinc	28-30	superoxide dismutase 1	Homo sapiens	39-61
35630637-1	2022	The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS).	Zinc	28-30	superoxide dismutase 1	Homo sapiens	63-67
35600978-6	2023	We further proved that Zn2+ released from ZnO NPs induced downregulation of beta-catenin expression via HIF-1alpha/BNIP3/LC3B-mediated mitophagy pathway.	Zinc	23-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
35556196-11	2022	Obesity also led to increased IL-1beta immunoreactivity in the cerebral cortex and hippocampus, which was reduced by Zn.	Zinc	117-119	interleukin 1 alpha	Rattus norvegicus	30-38
35556196-14	2022	Even though BCAA and Zn can affect IL-1beta immunoreactivity and astrocyte morphology, only Zn improved memory.	Zinc	21-23	interleukin 1 alpha	Rattus norvegicus	35-43
35600978-6	2023	We further proved that Zn2+ released from ZnO NPs induced downregulation of beta-catenin expression via HIF-1alpha/BNIP3/LC3B-mediated mitophagy pathway.	Zinc	23-27	BCL2 interacting protein 3	Homo sapiens	115-120
35488931-5	2022	In this review, we will discuss the role of Zn in the proper function of the p53 protein in cancer.	Zinc	44-46	tumor protein p53	Homo sapiens	77-80
35446026-3	2022	Herein, multistage photoactivatable Zn2+-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluating Zn2+ levels in dysfunctional islet beta-cells.	Zinc	36-40	apolipoprotein E	Homo sapiens	75-83
35446026-3	2022	Herein, multistage photoactivatable Zn2+-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluating Zn2+ levels in dysfunctional islet beta-cells.	Zinc	139-143	apolipoprotein E	Homo sapiens	75-83
35446026-6	2022	Our study introduced AD2@USD1 as a tool for effectively sensing, adjusting, and assessing the Zn2+ level in islet beta-cells with abnormalities, gaining a potential breakthrough in the treatment of diabetes.	Zinc	94-98	apolipoprotein E	Homo sapiens	21-29
35189329-7	2022	This is supported by experiments showing 100microM Zn2+ addition restored (3H)-progesterone binding of the Q206R mutant to levels in WT mPRalpha and increased (3H)-progesterone binding to mPRgamma and AdipoR1 which have arginine residues in this region.	Zinc	51-55	progestin and adipoQ receptor family member V	Mus musculus	188-196
35351309-5	2022	In addition, gene expression analysis showed that, the expression levels of the TaZIP3, TaZIP5, and TaZIP7 in roots were increased in both cultivars under Zn deficiency.	Zinc	155-157	zinc transporter 8	Triticum aestivum	88-94
35351309-5	2022	In addition, gene expression analysis showed that, the expression levels of the TaZIP3, TaZIP5, and TaZIP7 in roots were increased in both cultivars under Zn deficiency.	Zinc	155-157	zinc transporter 7	Triticum aestivum	100-106
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	48-52
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	173-177
35520290-11	2022	Of these parameters, only serum albumin level was significantly associated with serum Zn level (p=0.0024; estimated regression coefficient, 9.51; adjusted coefficient of determination, 0.28).	Zinc	86-88	albumin	Homo sapiens	32-39
35566673-5	2022	Insulin resistance in the group of women with PCOS caused a further SOD1 activity decrease, while Cu concentration and the value of Cu/Zn was increased when compared to women with normal insulin levels.	Zinc	135-137	insulin	Homo sapiens	0-7
35488931-9	2022	This includes understanding the relative populations of the Zn-bound and Zn-free p53 in wild-type and mutant forms, and the development of metallochaperones to re-populate the Zn binding site to restore mutant p53 activity.	Zinc	176-178	tumor protein p53	Homo sapiens	210-213
35488931-9	2022	This includes understanding the relative populations of the Zn-bound and Zn-free p53 in wild-type and mutant forms, and the development of metallochaperones to re-populate the Zn binding site to restore mutant p53 activity.	Zinc	60-62	tumor protein p53	Homo sapiens	81-84
35484480-7	2022	Sequence analysis of two key transporter families involved in the uptake and transport of Zn by the plant led to the identification of 32 Zinc Iron Permease (ZIP) transporters and 14 Heavy Metal Associated (HMA) transporters in tef.	Zinc	90-92	TEF transcription factor, PAR bZIP family member	Homo sapiens	228-231
35489423-4	2022	Following Zn co-treatment, Cd-mediated increase in IDO 1 protein expression, IDO, and TDO activities, and decrease in antioxidant enzymes, and an increase in markers of inflammatory response and MDA production were significantly (p < 0.05) reversed compared with control.	Zinc	10-12	tryptophan 2,3-dioxygenase	Rattus norvegicus	86-89
35489423-1	2022	The present study investigated the attenuating effects of Zn following Cd-exposure in the activities/expression of indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-dioxygenase (TDO), oxidative-inflammatory response, behavioral indices and histologic architecture in cerebral cortex and hippocampus of male rats.	Zinc	58-60	tryptophan 2,3-dioxygenase	Rattus norvegicus	151-178
35489423-1	2022	The present study investigated the attenuating effects of Zn following Cd-exposure in the activities/expression of indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-dioxygenase (TDO), oxidative-inflammatory response, behavioral indices and histologic architecture in cerebral cortex and hippocampus of male rats.	Zinc	58-60	tryptophan 2,3-dioxygenase	Rattus norvegicus	180-183
35253629-3	2022	Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent manner, resulting in facilitated degradation of MT (metallothionein) proteins, elevated distribution of Zn2+ within autophagosomes, decreased labile intracellular zinc ions, and increased growth, invasion, and metastasis of gastric cancer cells.	Zinc	201-205	E2F transcription factor 4 S homeolog	Xenopus laevis	47-51
35498405-7	2022	Structurally, p.His379Asn variant resulted in the loss of two Zn2+ binding sites in the protein dimer which may greatly affect ALP activity.	Zinc	62-66	alkaline phosphatase, placental	Homo sapiens	127-130
35212861-7	2022	Mechanistically, HrasG12V expression along with Zn2+ deficiency activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which are required for caspase-3 activation involved in the induction of cell death.	Zinc	48-52	mitogen-activated protein kinase 8	Homo sapiens	74-97
35212861-7	2022	Mechanistically, HrasG12V expression along with Zn2+ deficiency activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which are required for caspase-3 activation involved in the induction of cell death.	Zinc	48-52	mitogen-activated protein kinase 8	Homo sapiens	99-102
35212861-7	2022	Mechanistically, HrasG12V expression along with Zn2+ deficiency activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which are required for caspase-3 activation involved in the induction of cell death.	Zinc	48-52	mitogen-activated protein kinase 14	Homo sapiens	108-144
35212861-7	2022	Mechanistically, HrasG12V expression along with Zn2+ deficiency activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which are required for caspase-3 activation involved in the induction of cell death.	Zinc	48-52	caspase 3	Homo sapiens	176-185
35212861-9	2022	Further analyses of intracellular signaling biomolecules related to the UPR indicate that HrasG12V activates inositol-requiring protein 1 (IRE1), which synergizes with Zn2+ deficiency to activate JNK and p38 MAPK signaling.	Zinc	168-172	mitogen-activated protein kinase 8	Homo sapiens	196-199
35406753-5	2022	The TRPM family is formed by 8 members (TRPM1-8) permeable to Mg2+, Ca2+, Zn2+ and Na+ cations, and is activated by multiple stimuli.	Zinc	74-78	transient receptor potential cation channel subfamily M member 1	Homo sapiens	40-47
35421309-6	2022	Additionally, TRAAK binds more avidly to Cu2+ and Zn2+ than TREK2.	Zinc	50-54	potassium two pore domain channel subfamily K member 4	Homo sapiens	14-19
35559413-9	2022	The concentrations of Ca2+, Mg2+, Zn2+, and K+ increased in TGF-beta1- and TGF-beta2-treated ARPE-19 cells, while the concentration of Na+ decreased.	Zinc	34-38	transforming growth factor beta 1	Homo sapiens	60-69
35559413-10	2022	Significant inverse correlations were detected between the concentrations of Ca2+, Mg2+, Zn2+, and K+ and TEER values in ARPE-19 cells treated with TGF-beta1.	Zinc	89-93	transforming growth factor beta 1	Homo sapiens	148-157
35559413-13	2022	The time-effect analysis showed that the concentrations of Ca2+, Mg2+, Zn2+ and K+ increased and peaked after 72, 72, 48, and 72 h, respectively, with the extension of TGF-beta1 treatment time.	Zinc	71-75	transforming growth factor beta 1	Homo sapiens	168-177
35064350-6	2022	In contrast, isoproterenol reduced intracellular Zn2+ level increased by Abeta.	Zinc	49-53	amyloid beta precursor protein	Homo sapiens	73-78
35146899-8	2022	In addition, dissociated Zn2+ further breaks the redox balance of TME, and co-inhibits the expression of P-glycoprotein (P-gp) with generated ROS to overcome drug resistance.	Zinc	25-29	ATP binding cassette subfamily B member 1	Homo sapiens	105-119
35146899-8	2022	In addition, dissociated Zn2+ further breaks the redox balance of TME, and co-inhibits the expression of P-glycoprotein (P-gp) with generated ROS to overcome drug resistance.	Zinc	25-29	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
35169020-8	2022	Consistent with their localization, silencing of ZIP1 expression in vivo reduced Zn2+ uptake in CA3 neurons while ZIP3 silencing reduced Zn2+ influx into dentate gyrus granule cells in acute hippocampal slices.	Zinc	81-85	carbonic anhydrase 3	Mus musculus	96-99
35357432-5	2022	Accumulated Zn in thymocytes during development was released into the extracellular milieu after HSCT conditioning, where it triggered regeneration by stimulating endothelial cell-production of BMP4 via the cell surface receptor GPR39.	Zinc	12-14	bone morphogenetic protein 4	Mus musculus	194-198
35278236-5	2022	WVRQAPGKGL could inactivate ACE by binding to Zn2+ because of the presence of carboxyl in WVRQAPGKGL.	Zinc	46-50	angiotensin I converting enzyme	Homo sapiens	28-31
35581072-6	2022	Ion doping also significantly modulate the release of bioactive ions (Ca2+, PO43-, Zn2+, Ga3+) from the Zn-Ga:HAp depended on the overall amount of Ga and Zn in the HAp, which could mediate the biological responses.	Zinc	155-157	hemaglutinin-associated protein	Escherichia coli	110-113
35101650-6	2022	Furthermore, both compounds directly inhibited Abeta1-42 self-aggregation and chelated bio-metals such as Fe2+, Zn2+ and Cu2+ preventing reactive oxygen species (ROS) generation by Abeta and its oxidative damage in the brain regions of AD patients.	Zinc	112-116	amyloid beta precursor protein	Homo sapiens	181-186
35243588-2	2022	In our study, we aimed to investigate the relationship of SOD1 50-bp insertion(Ins)/deletion(Del) polymorphism that is involved in oxidative stress metabolism, Cu and Zn element concentrations, and plasma viscosity level, with postmenopausal osteoporosis and related vertebral fractures.	Zinc	167-169	superoxide dismutase 1	Homo sapiens	58-62
35077646-7	2022	In addition, the metal-binding proteins parvalbumin-alpha and carbonic anhydrase 2 were detected, identified, and imaged in their native form, i.e., parvalbumin-alpha + 2Ca2+ and carbonic anhydrase + Zn2+.	Zinc	200-204	carbonic anhydrase 2	Rattus norvegicus	62-82
35269490-3	2022	Since Zn2+ and permeant Mg2+ have similar physical properties, we tested if the RYR2 channel also conducts Zn2+.	Zinc	107-111	ryanodine receptor 2	Homo sapiens	80-84
35269490-4	2022	Using the method of planar lipid membranes, we evidenced that the RYR2 channel is permeable to Zn2+ with a considerable conductance of 81.1 +- 2.4 pS, which was significantly lower than the values for Ca2+ (127.5 +- 1.8 pS) and Mg2+ (95.3 +- 1.4 pS), obtained under the same asymmetric conditions.	Zinc	95-99	ryanodine receptor 2	Homo sapiens	66-70
35269490-7	2022	We attempted to displace Zn2+ from the RYR2 Zn2+ finger to induce its structural defects, which are associated with RYR2 dysfunction.	Zinc	25-29	ryanodine receptor 2	Homo sapiens	39-43
35269490-7	2022	We attempted to displace Zn2+ from the RYR2 Zn2+ finger to induce its structural defects, which are associated with RYR2 dysfunction.	Zinc	25-29	ryanodine receptor 2	Homo sapiens	116-120
35269490-7	2022	We attempted to displace Zn2+ from the RYR2 Zn2+ finger to induce its structural defects, which are associated with RYR2 dysfunction.	Zinc	44-48	ryanodine receptor 2	Homo sapiens	39-43
35269490-7	2022	We attempted to displace Zn2+ from the RYR2 Zn2+ finger to induce its structural defects, which are associated with RYR2 dysfunction.	Zinc	44-48	ryanodine receptor 2	Homo sapiens	116-120
35269490-10	2022	Our findings suggest that the RYR2 channel can provide a suitable pathway for rapid Zn2+ escape from the cardiac SR; thus, the channel may play a role in local and/or global Zn2+ signaling in cardiomyocytes.	Zinc	84-88	ryanodine receptor 2	Homo sapiens	30-34
35269490-10	2022	Our findings suggest that the RYR2 channel can provide a suitable pathway for rapid Zn2+ escape from the cardiac SR; thus, the channel may play a role in local and/or global Zn2+ signaling in cardiomyocytes.	Zinc	174-178	ryanodine receptor 2	Homo sapiens	30-34
35150430-10	2022	The results show that using 2.0 g of Zn/TNT photocatalysts under UV irradiation provided the highest VOC removal efficiency of 73%, suggesting the potential of application for burning incense in open areas.	Zinc	37-39	chromosome 16 open reading frame 82	Homo sapiens	40-43
35581072-2	2022	This study aims to synergistically promote antibacterial and osteoconductive properties of hydroxyapatite (HAp) nanoparticles through binary doping of Zn2+ and Ga3+ ions (Zn-Ga:HAp).	Zinc	151-155	hemaglutinin-associated protein	Escherichia coli	107-110
35581072-2	2022	This study aims to synergistically promote antibacterial and osteoconductive properties of hydroxyapatite (HAp) nanoparticles through binary doping of Zn2+ and Ga3+ ions (Zn-Ga:HAp).	Zinc	151-155	hemaglutinin-associated protein	Escherichia coli	177-180
35581072-6	2022	Ion doping also significantly modulate the release of bioactive ions (Ca2+, PO43-, Zn2+, Ga3+) from the Zn-Ga:HAp depended on the overall amount of Ga and Zn in the HAp, which could mediate the biological responses.	Zinc	83-87	hemaglutinin-associated protein	Escherichia coli	110-113
35581072-6	2022	Ion doping also significantly modulate the release of bioactive ions (Ca2+, PO43-, Zn2+, Ga3+) from the Zn-Ga:HAp depended on the overall amount of Ga and Zn in the HAp, which could mediate the biological responses.	Zinc	104-107	hemaglutinin-associated protein	Escherichia coli	110-113
35581072-7	2022	Incorporating both Zn2+ and Ga3+ ions in HAp structure could significantly improve the antibacterial activity of HAp nanopowders against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) with a concentration-dependent effect.	Zinc	19-23	hemaglutinin-associated protein	Escherichia coli	41-44
35581072-7	2022	Incorporating both Zn2+ and Ga3+ ions in HAp structure could significantly improve the antibacterial activity of HAp nanopowders against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) with a concentration-dependent effect.	Zinc	19-23	hemaglutinin-associated protein	Escherichia coli	113-116
35123262-6	2022	Meanwhile, we analyzed the content of Zn2+ and Ca2+ through EM imaging and energy dispersive spectroscopy (EDS) mapping, and the content of Zn2+ was found to be proportional to the size of insulin vesicles.	Zinc	38-42	insulin	Homo sapiens	189-196
35174244-4	2022	The mRNA expression levels of critical antioxidant enzymes such as SOD, CAT, and nuclear factor erythroid 2-related factor 2 (Nrf2) were increased by Zn in the jejunum (P < 0.05).	Zinc	150-152	catalase	Anas platyrhynchos	72-75
35168023-6	2022	The Cu:Zn ratio (log scale) positively correlated with CRP (log scale; r = 0.581, p < 0.001) and NLR (r = 0.436, p = 0.003).	Zinc	7-9	C-reactive protein	Homo sapiens	55-58
35123262-6	2022	Meanwhile, we analyzed the content of Zn2+ and Ca2+ through EM imaging and energy dispersive spectroscopy (EDS) mapping, and the content of Zn2+ was found to be proportional to the size of insulin vesicles.	Zinc	140-144	insulin	Homo sapiens	189-196
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	42-46	signal transducer and activator of transcription 3	Mus musculus	104-109
35207503-2	2022	Here, we showed that the T-DNA insertion-induced inhibition of the BRUTUS (BTS) gene in the bts-1 mutant greatly improved Zn tolerance, as indicated by increased biomass production and reduced leaf chlorosis.	Zinc	122-124	bladder tumor susceptibility 1	Homo sapiens	92-97
35207503-3	2022	The ProBTS::BTS-GFP complementation in the bts-1 mutant abolished the improvement of Zn tolerance.	Zinc	85-87	bladder tumor susceptibility 1	Homo sapiens	43-48
35207503-4	2022	Unexpectedly, the bts-1 mutant had higher and comparable Zn concentrations in the roots and citrate effluxer shoots, respectively, compared to wild-type plants.	Zinc	57-59	bladder tumor susceptibility 1	Homo sapiens	18-23
35207503-5	2022	As a result, the shoots and roots of bts-1 mutants had 53% and 193% more Zn accumulation than the wild-type plants, respectively.	Zinc	73-75	bladder tumor susceptibility 1	Homo sapiens	37-42
35207503-6	2022	RNA-seq analyses revealed that the Fe nutrition-related genes were upregulated in bts-1 mutants, especially under Zn stress conditions.	Zinc	114-116	bladder tumor susceptibility 1	Homo sapiens	82-87
35207503-7	2022	Therefore, the bts-1 mutants had a greater Fe concentration and a higher Fe/Zn ratio than the wild-type plants exposed to Zn toxicity.	Zinc	76-78	bladder tumor susceptibility 1	Homo sapiens	15-20
35207503-7	2022	Therefore, the bts-1 mutants had a greater Fe concentration and a higher Fe/Zn ratio than the wild-type plants exposed to Zn toxicity.	Zinc	122-124	bladder tumor susceptibility 1	Homo sapiens	15-20
35207503-8	2022	Further study showed that the differences in Zn tolerance between bts-1 and wild-type plants were minimized by eliminating Fe or supplementing excessive Fe in the growth medium.	Zinc	45-47	bladder tumor susceptibility 1	Homo sapiens	66-71
35095413-4	2021	Herein, we explored the role of Zn2+ in the regulation of acute and chronic itch in mice.	Zinc	32-36	itchy, E3 ubiquitin protein ligase	Mus musculus	76-80
35095413-6	2021	of Zn2+ dose-dependently induced acute itch and transient receptor potential A1 (TRPA1) participated in Zn2+-induced acute itch in mice.	Zinc	3-7	itchy, E3 ubiquitin protein ligase	Mus musculus	39-43
35095413-6	2021	of Zn2+ dose-dependently induced acute itch and transient receptor potential A1 (TRPA1) participated in Zn2+-induced acute itch in mice.	Zinc	104-108	itchy, E3 ubiquitin protein ligase	Mus musculus	123-127
35095413-7	2021	Moreover, the pharmacological analysis showed the involvement of histamine, mast cells, opioid receptors, and capsaicin-sensitive C-fibers in Zn2+-induced acute itch in mice.	Zinc	142-146	itchy, E3 ubiquitin protein ligase	Mus musculus	161-165
35296207-12	2022	In conclusion, an increase of p67phox expression in response to Zn2+ is an intrinsic adaptive response to I/R and leads to cardioprotection against I/R by upregulating ZIP2 via STAT3.	Zinc	64-68	signal transducer and activator of transcription 3	Mus musculus	177-182
35160454-4	2022	To apply the procedure to NO3- determination, dispersed Zn nanoparticles (ZnNPs) were employed.	Zinc	56-58	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
35095413-10	2021	Activation of extracellular signal-regulated kinase (ERK) pathway was induced in the DRG and skin by the administration of zinc or under dry skin condition, which was inhibited by systemic administration of Zn2+ chelators.	Zinc	207-211	mitogen-activated protein kinase 1	Mus musculus	14-51
35095413-10	2021	Activation of extracellular signal-regulated kinase (ERK) pathway was induced in the DRG and skin by the administration of zinc or under dry skin condition, which was inhibited by systemic administration of Zn2+ chelators.	Zinc	207-211	mitogen-activated protein kinase 1	Mus musculus	53-56
34652859-2	2022	We propose a WSM Co3 Sn2 S2 cathode for AZIBs showing a discharge plateau around 1.5 V. By introducing Sn vacancies, extra redox peaks from the Sn4+ /Sn2+ transition appear, which leads to more Zn2+ transfer channels and active sites promoting charge-storage kinetics and Zn2+ storage capability.	Zinc	194-198	solute carrier family 38 member 5	Homo sapiens	21-24
34652859-2	2022	We propose a WSM Co3 Sn2 S2 cathode for AZIBs showing a discharge plateau around 1.5 V. By introducing Sn vacancies, extra redox peaks from the Sn4+ /Sn2+ transition appear, which leads to more Zn2+ transfer channels and active sites promoting charge-storage kinetics and Zn2+ storage capability.	Zinc	194-198	solute carrier family 38 member 5	Homo sapiens	150-153
34652859-2	2022	We propose a WSM Co3 Sn2 S2 cathode for AZIBs showing a discharge plateau around 1.5 V. By introducing Sn vacancies, extra redox peaks from the Sn4+ /Sn2+ transition appear, which leads to more Zn2+ transfer channels and active sites promoting charge-storage kinetics and Zn2+ storage capability.	Zinc	272-276	solute carrier family 38 member 5	Homo sapiens	21-24
34652859-2	2022	We propose a WSM Co3 Sn2 S2 cathode for AZIBs showing a discharge plateau around 1.5 V. By introducing Sn vacancies, extra redox peaks from the Sn4+ /Sn2+ transition appear, which leads to more Zn2+ transfer channels and active sites promoting charge-storage kinetics and Zn2+ storage capability.	Zinc	272-276	solute carrier family 38 member 5	Homo sapiens	150-153
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	154-158	signal transducer and activator of transcription 3	Mus musculus	104-109
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	209-213	signal transducer and activator of transcription 3	Mus musculus	104-109
2695115-13	1989	Independent transformation of the Zn2+ trimers is possible in Zn2+/Co3+ metal hybrids of insulin.	Zinc	34-37	insulin	Homo sapiens	89-96
2695115-13	1989	Independent transformation of the Zn2+ trimers is possible in Zn2+/Co3+ metal hybrids of insulin.	Zinc	34-38	insulin	Homo sapiens	89-96
2511329-7	1989	DNase I protection studies show that poly(ADP-ribose)polymerase specifically binds to a DNA single-strand break by its metal-binding domain depending upon the presence of Zn(II).	Zinc	171-173	poly(ADP-ribose) polymerase 1	Homo sapiens	37-63
2613443-3	1989	Cd(II) and Co(II) also behave as Zn(II).	Zinc	33-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
2620798-6	1989	To elucidate the mechanism of this inhibition, binding of Zn(II) (0.5-50 microM 65ZnCl2) to CAM in the presence of Ca(II) (200 microM) was also studied.	Zinc	58-64	calmodulin 1	Homo sapiens	92-95
2620798-7	1989	The maximum molecular ratio of Zn(II) to CAM in the Zn(II)/Ca(II)/CAM complex approached 0.5.	Zinc	31-37	calmodulin 1	Homo sapiens	66-69
2620798-7	1989	The maximum molecular ratio of Zn(II) to CAM in the Zn(II)/Ca(II)/CAM complex approached 0.5.	Zinc	52-58	calmodulin 1	Homo sapiens	41-44
2620798-7	1989	The maximum molecular ratio of Zn(II) to CAM in the Zn(II)/Ca(II)/CAM complex approached 0.5.	Zinc	52-58	calmodulin 1	Homo sapiens	66-69
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	33-39	calmodulin 1	Homo sapiens	72-75
2481439-4	1989	Phosphorylase kinase activity was clearly present in extracts from cultures of pEV gamma PhK-transformed cells and increased several-fold after 24 h of incubation with Zn2+, whereas it was undetectable in the parent 3T3 cells.	Zinc	168-172	phosphorylase kinase alpha 2	Mus musculus	89-92
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	33-39	calmodulin 1	Homo sapiens	188-191
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	206-212	calmodulin 1	Homo sapiens	72-75
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	206-212	calmodulin 1	Homo sapiens	188-191
2605181-5	1989	Elemental analysis indicates a redistribution of Zn(II) from the fibrinogen to the albumin compartment, and the resultant fibrin clots are less turbid.	Zinc	49-55	fibrinogen beta chain	Homo sapiens	65-75
2759737-0	1989	Zn++ inhibits both tumor necrosis factor-mediated DNA fragmentation and cytolysis.	Zinc	0-4	tumor necrosis factor	Homo sapiens	19-40
2759737-2	1989	In the present study we have analyzed in detail the effect of Zn++, an inhibitor of endonucleases, on TNF-mediated DNA-fragmentation and on cytolysis in Actinomycin-D-pre-treated WEHII 64-S cells.	Zinc	62-66	tumor necrosis factor	Homo sapiens	102-105
2759737-5	1989	Addition of Zn++ to TNF-treated WEHII64 cells completely abrogates DNA fragmentation at ImM.	Zinc	12-16	tumor necrosis factor	Homo sapiens	20-23
2759737-6	1989	Of greater importance is the fact that Zn++ treatment also completely blocks TNF-mediated cytolysis of the target cells.	Zinc	39-43	tumor necrosis factor	Homo sapiens	77-80
2759737-9	1989	Zn++ added 2 hr after TNF treatment, still effectively inhibits cell lysis, indicating that it acts at a late stage after binding of TNF to its receptor.	Zinc	0-4	tumor necrosis factor	Homo sapiens	22-25
2759737-9	1989	Zn++ added 2 hr after TNF treatment, still effectively inhibits cell lysis, indicating that it acts at a late stage after binding of TNF to its receptor.	Zinc	0-4	tumor necrosis factor	Homo sapiens	133-136
2502006-5	1989	The percent content of free cholesterol in HDL-E2 was increased in ZD compared with PF and CT. Zn deficiency decreased the plasma concentrations of apo A-I and apo C of HDL-E0 and total apo E associated with HDL-E1 and HDL-E2.	Zinc	95-97	apolipoprotein E	Rattus norvegicus	186-191
2759245-2	1989	We have recently described the sequence of the Zn2+-binding domain (43 amino acid residues) of a newly detected Zn2+-binding protein which reversibly inactivates phosphofructokinase-1 in a Zn2+-dependent manner [(1986) J. Biol.	Zinc	47-51	phosphofructokinase, muscle	Rattus norvegicus	162-183
2759245-2	1989	We have recently described the sequence of the Zn2+-binding domain (43 amino acid residues) of a newly detected Zn2+-binding protein which reversibly inactivates phosphofructokinase-1 in a Zn2+-dependent manner [(1986) J. Biol.	Zinc	112-116	phosphofructokinase, muscle	Rattus norvegicus	162-183
2765555-0	1989	Effects of Ca2+ and Zn2+ on trifluoperazine-S100 proteins interactions: induced circular dichroism and fluorescence spectra.	Zinc	20-24	S100 calcium binding protein B	Homo sapiens	44-48
2765555-6	1989	From these results together with other experimental findings it was suggested that (1) TFP binds to S100a protein and S100a0 protein in the presence of Ca2+, with half-saturation points of 18 and 3 microM, respectively, (2) TFP binds to S100b protein only in the presence of Zn2+, (3) alpha-subunit of S100 protein binds to TFP specifically in a Ca2+-dependent manner and beta-subunit in a Zn2+-dependent manner.	Zinc	275-279	S100 calcium binding protein B	Homo sapiens	237-242
2765555-6	1989	From these results together with other experimental findings it was suggested that (1) TFP binds to S100a protein and S100a0 protein in the presence of Ca2+, with half-saturation points of 18 and 3 microM, respectively, (2) TFP binds to S100b protein only in the presence of Zn2+, (3) alpha-subunit of S100 protein binds to TFP specifically in a Ca2+-dependent manner and beta-subunit in a Zn2+-dependent manner.	Zinc	275-279	S100 calcium binding protein B	Homo sapiens	100-104
2765555-6	1989	From these results together with other experimental findings it was suggested that (1) TFP binds to S100a protein and S100a0 protein in the presence of Ca2+, with half-saturation points of 18 and 3 microM, respectively, (2) TFP binds to S100b protein only in the presence of Zn2+, (3) alpha-subunit of S100 protein binds to TFP specifically in a Ca2+-dependent manner and beta-subunit in a Zn2+-dependent manner.	Zinc	390-394	S100 calcium binding protein B	Homo sapiens	237-242
2765555-6	1989	From these results together with other experimental findings it was suggested that (1) TFP binds to S100a protein and S100a0 protein in the presence of Ca2+, with half-saturation points of 18 and 3 microM, respectively, (2) TFP binds to S100b protein only in the presence of Zn2+, (3) alpha-subunit of S100 protein binds to TFP specifically in a Ca2+-dependent manner and beta-subunit in a Zn2+-dependent manner.	Zinc	390-394	S100 calcium binding protein B	Homo sapiens	100-104
2526132-5	1989	Zn++ (50 microM) was required for binding of 125I-fibrinogen to neutrophils at 4 degrees C and the addition of Ca++ (2 mM) increased the binding twofold.	Zinc	0-4	fibrinogen beta chain	Homo sapiens	50-60
2484577-6	1989	Low dosages of Zn increased MT-II levels three times higher than MT-I levels, whereas higher dosages increased the isoforms to similar levels.	Zinc	15-17	metallothionein 1	Rattus norvegicus	28-32
2484577-7	1989	Differences in the degradation of Zn-induced MTs were observed: apparent half-lives for MT-I and MT-II were 12.2 and 21.9 h, respectively.	Zinc	34-36	metallothionein 1	Rattus norvegicus	88-92
2526132-14	1989	Fibrinogen binding to ADP-stimulated platelets was increased twofold by Zn++ (50 microM) and was inhibited by HMWK.	Zinc	72-76	fibrinogen beta chain	Homo sapiens	0-10
2540174-7	1989	Cd2+ increased [3H]inositol polyphosphates; [3H]inositol trisphosphate increased 4-fold in 15 s. Zn2+ reversibly blocked 45Ca2+ efflux evoked by Cd2+ but not that produced by bradykinin.	Zinc	97-101	kininogen 1	Homo sapiens	175-185
2738152-4	1989	Human neutrophils were found to possess surface membrane-binding sites for HMWK but no internalization was detected at 37 degrees C. 125I-HMWK binding to neutrophils was dependent upon Zn2+.	Zinc	185-189	kininogen 1	Homo sapiens	138-142
2663607-5	1989	On the other hand, localization of hepatic tissue Cu, Zn-SOD in alcoholics varied, being 63.2% in the cytoplasmic diffuse type, 42.0% in the nuclear diffuse type, 42.1% in the vacuolated membrane type, and 15.8% in the small granular type respectively.	Zinc	54-56	superoxide dismutase 1	Homo sapiens	57-60
2500271-10	1989	The overall increase in URO-S was from 2.67 to 8.90 U (-Zn; -DTT) and from 3.02 to 8.66 U (+Zn; +DTT).	Zinc	56-58	hydroxymethylbilane synthase	Homo sapiens	24-29
2500271-10	1989	The overall increase in URO-S was from 2.67 to 8.90 U (-Zn; -DTT) and from 3.02 to 8.66 U (+Zn; +DTT).	Zinc	92-94	hydroxymethylbilane synthase	Homo sapiens	24-29
2760310-2	1989	Feeding 2000 ppm Zn decreased milk yield and feed intake after several weeks.	Zinc	17-19	Weaning weight-maternal milk	Bos taurus	30-34
2760310-5	1989	Milk Zn was materially higher for cows fed 1000 ppm added Zn than controls.	Zinc	5-7	Weaning weight-maternal milk	Bos taurus	0-4
2760310-5	1989	Milk Zn was materially higher for cows fed 1000 ppm added Zn than controls.	Zinc	58-60	Weaning weight-maternal milk	Bos taurus	0-4
2760310-6	1989	With 2000 ppm Zn, milk Zn was elevated further but returned to control values when the high Zn diet was discontinued.	Zinc	14-16	Weaning weight-maternal milk	Bos taurus	18-22
2760310-6	1989	With 2000 ppm Zn, milk Zn was elevated further but returned to control values when the high Zn diet was discontinued.	Zinc	23-25	Weaning weight-maternal milk	Bos taurus	18-22
2760310-6	1989	With 2000 ppm Zn, milk Zn was elevated further but returned to control values when the high Zn diet was discontinued.	Zinc	23-25	Weaning weight-maternal milk	Bos taurus	18-22
2728004-1	1989	The metallothionein-I (MT-I) content of urine following administration of cadmium (Cd), copper (Cu), mercury (Hg) or zinc (Zn) to rats was determined by radioimmunoassay.	Zinc	123-125	metallothionein 1	Rattus norvegicus	4-21
2728004-1	1989	The metallothionein-I (MT-I) content of urine following administration of cadmium (Cd), copper (Cu), mercury (Hg) or zinc (Zn) to rats was determined by radioimmunoassay.	Zinc	123-125	metallothionein 1	Rattus norvegicus	23-27
2648161-1	1989	SINCE insulin was first shown by Scott to crystallize in the presence of zinc ions in 1934, a variety of Zn-containing insulin crystals have been grown.	Zinc	105-107	insulin	Homo sapiens	6-13
2532855-2	1989	The data from this experiment show that Met-Enk can suppress the responses of splenocyte from the 3 groups to concanavalin A (Con A), but less inhibition was observed in the Zn-deficient group.	Zinc	174-176	preproenkephalin	Mus musculus	44-47
2532855-5	1989	In the proliferation of MLC, the response of lymphocytes from Zn-deficient mice was increased in the absence of Met-Enk and Met-Enk can suppress this increased response.	Zinc	62-64	preproenkephalin	Mus musculus	116-119
2532855-5	1989	In the proliferation of MLC, the response of lymphocytes from Zn-deficient mice was increased in the absence of Met-Enk and Met-Enk can suppress this increased response.	Zinc	62-64	preproenkephalin	Mus musculus	128-131
2648161-1	1989	SINCE insulin was first shown by Scott to crystallize in the presence of zinc ions in 1934, a variety of Zn-containing insulin crystals have been grown.	Zinc	105-107	insulin	Homo sapiens	119-126
2648161-2	1989	The structures of insulin in the related rhombohedral crystals of 2Zn-insulin and 4Zn-insulin have been solved and reveal that the molecule is a hexamer, organized as three dimers, each containing a 2-fold symmetry axis and held together by Zn ions.	Zinc	67-69	insulin	Homo sapiens	18-25
2466831-11	1989	In contrast, the yield of "F" alpha 2M IL-1 beta complex formation was increased severalfold in the presence of 2.5 mM Zn2+.	Zinc	119-123	interleukin 1 beta	Homo sapiens	39-48
2648161-2	1989	The structures of insulin in the related rhombohedral crystals of 2Zn-insulin and 4Zn-insulin have been solved and reveal that the molecule is a hexamer, organized as three dimers, each containing a 2-fold symmetry axis and held together by Zn ions.	Zinc	67-69	insulin	Homo sapiens	70-77
2648161-2	1989	The structures of insulin in the related rhombohedral crystals of 2Zn-insulin and 4Zn-insulin have been solved and reveal that the molecule is a hexamer, organized as three dimers, each containing a 2-fold symmetry axis and held together by Zn ions.	Zinc	67-69	insulin	Homo sapiens	70-77
2648161-3	1989	In 2Zn-insulin the hexamer is nearly symmetrical with the two axial Zn ions and the two molecules of the dimer related closely by a local 2-fold axis.	Zinc	4-6	insulin	Homo sapiens	7-14
2488172-0	1989	Application of scanning electron microscopy and energy-dispersive X-ray analysis to the solution behaviour of Zn-insulin: precipitation phenomena.	Zinc	110-112	insulin	Homo sapiens	113-120
2540266-1	1989	In vitro studies on Zn2+-induced modulations in certain allosteric control of fructose-1,6-bisphosphatase (FBPase: EC 3.1.3.11), isolated from liver and muscle of 28- and 97-wk old rats were carried out in parallel.	Zinc	20-24	fructose-bisphosphatase 2	Rattus norvegicus	107-113
2540266-4	1989	However, in case of muscle FBPase, apart from a significant increase in Ki for ZnCl2, Zn2+-induced modulations in substrate affinity and AMP inhibition were observed to be altered markedly with the enzyme of 97-wk-old rats in comparison to that of 28-wk-old rats.	Zinc	86-90	fructose-bisphosphatase 2	Rattus norvegicus	20-33
2540266-7	1989	Such age-dependent changes induced by Zn2+ in muscle FBPase may be of high physiological significance with advancing age of the animal.	Zinc	38-42	fructose-bisphosphatase 2	Rattus norvegicus	46-59
2645390-6	1989	Levels of hepatic MT mRNA were rapidly induced by metal ions (Cd2+, Zn2+, Cu2+), glucocorticoids and lipopolysaccharide (LPS).	Zinc	68-72	metallothionein 4	Gallus gallus	18-20
2488172-6	1989	It was demonstrated with the EDAX method that the particles occasionally found in clear Zn-insulin solutions contain insulin as well as Zn in roughly the same ratio as in the insulin starting material.	Zinc	88-90	insulin	Homo sapiens	117-124
2488172-6	1989	It was demonstrated with the EDAX method that the particles occasionally found in clear Zn-insulin solutions contain insulin as well as Zn in roughly the same ratio as in the insulin starting material.	Zinc	136-138	insulin	Homo sapiens	91-98
2746218-3	1989	In the absence of other divalent cations, 6 mol of Zn2+ bind to calmodulin with an identical affinity constant of 2,850 M-1 and a delta H0 of 106 kJ/mol calmodulin.	Zinc	51-55	calmodulin 1	Homo sapiens	64-74
2746218-3	1989	In the absence of other divalent cations, 6 mol of Zn2+ bind to calmodulin with an identical affinity constant of 2,850 M-1 and a delta H0 of 106 kJ/mol calmodulin.	Zinc	51-55	calmodulin 1	Homo sapiens	153-163
2746218-4	1989	In the presence of millimolar free Ca2+ calmodulin binds, in addition to four Ca2+, six Zn2+ with an affinity constant of 1,200 M-1 and a delta H0 of 47 kJ/mol calmodulin.	Zinc	88-92	calmodulin 1	Homo sapiens	40-50
2909550-1	1989	High serum PRL and low zinc (Zn) levels are common findings in patients with chronic renal failure (CRF); in such patients serum Zn concentrations have been reported to be inversely correlated to serum PRL levels.	Zinc	129-131	prolactin	Homo sapiens	11-14
2909550-1	1989	High serum PRL and low zinc (Zn) levels are common findings in patients with chronic renal failure (CRF); in such patients serum Zn concentrations have been reported to be inversely correlated to serum PRL levels.	Zinc	129-131	prolactin	Homo sapiens	202-205
2488172-1	1989	Scanning electron microscopy (SEM) has been applied in combination with energy dispersive X-ray analysis (EDAX) to identify and analyse particles or particulate matter, occasionally present in clear neutral Zn-insulin solutions.	Zinc	207-209	insulin	Homo sapiens	210-217
2488172-6	1989	It was demonstrated with the EDAX method that the particles occasionally found in clear Zn-insulin solutions contain insulin as well as Zn in roughly the same ratio as in the insulin starting material.	Zinc	88-90	insulin	Homo sapiens	91-98
2488172-6	1989	It was demonstrated with the EDAX method that the particles occasionally found in clear Zn-insulin solutions contain insulin as well as Zn in roughly the same ratio as in the insulin starting material.	Zinc	88-90	insulin	Homo sapiens	117-124
2849100-7	1988	Since earlier experiments suggested that a single Zn atom was bound per molecule of ACE, only one of the two domains should be catalytically active.	Zinc	50-52	angiotensin I converting enzyme	Homo sapiens	84-87
2848987-3	1988	In contrast, Zn2+ inhibited the interaction of 2-hydroxyestradiol with microsomal protein as measured by the release of 3H from C-4 of the labeled steroids but did not influence 2-hydroxylation, except at high concentration.	Zinc	13-17	complement C4A	Rattus norvegicus	128-131
2536893-6	1989	In the absence of metallothionein induction, these cells exhibited nearly normal PTH responsiveness, but after REV-1 induction by Zn2+, they were resistant to PTH-induced activation of PK-A and regulation of membrane phospholipid synthesis by both PTH and cAMP analogs.	Zinc	130-134	REV1, DNA directed polymerase	Rattus norvegicus	111-116
2536893-7	1989	The mutant UMR 4-7 cell provides a model system in which the consequences of cAMP production by PTH or other agonists that activate adenylate cyclase in osteoblasts may be specifically inhibited by brief exposure to Zn2+.	Zinc	216-220	parathyroid hormone	Rattus norvegicus	96-99
2460446-7	1988	125I-HMWK specifically binds to HUVEC in a reaction requiring Zn2+.	Zinc	62-66	kininogen 1	Homo sapiens	5-9
3049586-5	1988	The specific alpha-mannosidase does not require the addition of divalent cation for activity, but it is inhibited by Tris, EDTA, Mn2+, Co2+, Zn2+, and Mg2+.	Zinc	141-145	alpha-mannosidase	Saccharomyces cerevisiae S288C	13-30
2464135-1	1988	A murine hybridoma clone (MT 189-14-7) producing an IgM-class monoclonal antibody specific for metallothionein (MT) was produced with rat Zn-MT 2-keyhole limpet hemocyanin conjugate as an immunogen.	Zinc	138-140	metallothionein 2	Mus musculus	141-145
3221854-0	1988	[Hydrolytic activity of bovine tryptophanyl-tRNA-synthetase cause by removal of Zn2+].	Zinc	80-84	tryptophanyl-tRNA synthetase 1	Bos taurus	31-59
3221854-1	1988	Bovine tryptophanyl-tRNA synthetase (E.C.6.1.1.2) lacking Zn2+ ions removed by chelation with phosphonate analog of P1,P4-bis-(5"-adenosyl)tetraphosphate (Ap4A) was obtained (E-Zn).	Zinc	58-62	tryptophanyl-tRNA synthetase 1	Bos taurus	7-35
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Zinc	54-56	CD4 molecule	Homo sapiens	0-3
2841312-1	1988	Angiotensin-converting enzyme (ACE) is an Zn(II)-containing dipeptidyl carboxypeptidase that converts angiotensin I to the potent vasoconstrictor, angiotensin II.	Zinc	42-48	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	102-115
3419630-5	1988	However, selected cations (50 mM Cl- salts) significantly inhibited DPP-II activity compared to Na+ control; the relative inhibition ranking was Rb+ less than K+ less than Zn2+ less than Hg2+.	Zinc	172-176	dipeptidylpeptidase 7	Rattus norvegicus	68-74
3218145-1	1988	Tetraphenyl porphyrin (TPP) and its complexes with Fe3+, Co2+, Cu2+, Zn2+ and Ni2+ inhibited cytochrome P-450-dependent enzymes in rat liver microsomes.	Zinc	69-73	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Zinc	109-111	CD4 molecule	Homo sapiens	0-3
3191188-1	1988	ESR study was carried out of the interaction between Zn2+, Cu2+, Ca2+, Mg2+ ions and human serum albumin (HSA) in the presence of Mn2+ ions which depends on pH.	Zinc	53-57	albumin	Homo sapiens	91-104
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-52
2453623-5	1988	The activities of the pancreatic exportable enzymes amylase, lipase, trypsinogen and chymotrypsinogen were each decreased by such levels of Zn feeding.	Zinc	140-142	trypsin II-P29-like	Gallus gallus	69-80
3411318-2	1988	This effect was detected on the enzyme having Co(II) substituted for the native Zn(II), in which the resonances of residues bound to the copper are detected because of the antiferromagnetic coupling between Cu(II) and Co(II).	Zinc	80-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-224
3368479-9	1988	Thus the initial level of Zn in the yolk has a significant impact on the final concentration of MT in neonatal liver.	Zinc	26-28	metallothionein 4	Gallus gallus	96-98
3368479-10	1988	A study of MT induction in the 18-DI embryo revealed that yolk sac administration of Zn (550, 2750, 4950 micrograms/yolk) increased hepatic MT by 5.8-, 23-, and 39-fold, respectively.	Zinc	85-87	metallothionein 4	Gallus gallus	11-13
3368479-10	1988	A study of MT induction in the 18-DI embryo revealed that yolk sac administration of Zn (550, 2750, 4950 micrograms/yolk) increased hepatic MT by 5.8-, 23-, and 39-fold, respectively.	Zinc	85-87	metallothionein 4	Gallus gallus	140-142
3273655-0	1988	Estrogen receptor interaction with immobilized metals: differential molecular recognition of Zn2+, Cu2+ and Ni2+ and separation of receptor isoforms.	Zinc	93-97	estrogen receptor 1	Homo sapiens	0-17
2833519-3	1988	Noncovalent interaction between tau and S100b depended on the presence of Ca2+ or Zn2+ and resulted in total inhibition of tau phosphorylation by protein kinase II.	Zinc	82-86	S100 calcium binding protein B	Homo sapiens	40-45
2831899-3	1988	The PPT phosphatase activity of the membranes, using 32P-histone 2b as a substrate, was inhibited by 100 microM Zn+2, insensitive to 10 mM EDTA, and displayed maximal activity at neutral pH.	Zinc	112-116	histone cluster 1, H2bg	Rattus norvegicus	57-67
3342017-6	1988	profiles (using an anion-exchange column) of the isolated MT-1 and MT-2 subfractions from Zn-treated normal-mouse liver showed a single peak (MT-1-1) and two peaks (MT-2-1 and MT-2-2) respectively; mouse MTs were separated into three isoforms.	Zinc	90-92	metallothionein 1	Mus musculus	58-71
2831899-3	1988	The PPT phosphatase activity of the membranes, using 32P-histone 2b as a substrate, was inhibited by 100 microM Zn+2, insensitive to 10 mM EDTA, and displayed maximal activity at neutral pH.	Zinc	112-116	protein phosphatase 5, catalytic subunit	Rattus norvegicus	4-7
2893589-11	1988	Factor XIII was fully activated by both trypsin and thrombin in the presence of 5 mM Zn2+, resulting in two fragments of 76 and 72 kDa.	Zinc	85-89	coagulation factor II, thrombin	Homo sapiens	52-60
3339475-1	1988	The effect of the route of zinc (Zn) administration on the induction of metallothionein (MT) in various tissues of chicks was examined.	Zinc	33-35	metallothionein 4	Gallus gallus	72-87
3339475-1	1988	The effect of the route of zinc (Zn) administration on the induction of metallothionein (MT) in various tissues of chicks was examined.	Zinc	33-35	metallothionein 4	Gallus gallus	89-91
3342017-6	1988	profiles (using an anion-exchange column) of the isolated MT-1 and MT-2 subfractions from Zn-treated normal-mouse liver showed a single peak (MT-1-1) and two peaks (MT-2-1 and MT-2-2) respectively; mouse MTs were separated into three isoforms.	Zinc	90-92	metallothionein 1	Mus musculus	58-62
3342017-6	1988	profiles (using an anion-exchange column) of the isolated MT-1 and MT-2 subfractions from Zn-treated normal-mouse liver showed a single peak (MT-1-1) and two peaks (MT-2-1 and MT-2-2) respectively; mouse MTs were separated into three isoforms.	Zinc	90-92	metallothionein 2	Mus musculus	67-71
3435496-8	1987	Binding of Zn2+ alone to human apo-SOD resulted in the formation of two distinct structural units, detectable by differential scanning calorimetry, which underwent conformational disorder at 82 and 101 degrees C respectively.	Zinc	11-15	superoxide dismutase 1	Homo sapiens	35-38
2837338-0	1988	Effect of Ca2+ and Zn2+ on 5"-nucleotidase activity in rat liver plasma membranes: hepatic calcium-binding protein (regucalcin) reverses the Ca2+ effect.	Zinc	19-23	regucalcin	Rattus norvegicus	116-126
3346660-1	1988	The effect of Cu(II), Ni(II), Zn(II), Mg(II), and Mn(II) on the fluorescence of porcine kidney cytosol leucine aminopeptidase and three of its dansyl(Dns) peptide substrates, Leu-Gly-NHNH-Dns, Leu-Gly-NH(CH2)2NH-Dns, and Leu-Gly-NH(CH2)6NH-Dns, has been investigated.	Zinc	30-36	carboxypeptidase Q	Homo sapiens	111-125
20501311-5	1988	Zn(2+), which can bind both microtubule proteins and S100 protein, had little effect on the inhibitory action of S100 protein.	Zinc	0-2	S100 calcium binding protein B	Homo sapiens	53-57
3341018-1	1988	The purpose of this study was to determine the role of transcription, translation, and protein degradation on the accumulation of metallothionein-I (MT-I) and metallothionein-II (MT-II) in rat liver following induction of these proteins by Zn.	Zinc	240-242	metallothionein 1	Rattus norvegicus	130-147
3341018-1	1988	The purpose of this study was to determine the role of transcription, translation, and protein degradation on the accumulation of metallothionein-I (MT-I) and metallothionein-II (MT-II) in rat liver following induction of these proteins by Zn.	Zinc	240-242	metallothionein 1	Rattus norvegicus	149-153
3341018-1	1988	The purpose of this study was to determine the role of transcription, translation, and protein degradation on the accumulation of metallothionein-I (MT-I) and metallothionein-II (MT-II) in rat liver following induction of these proteins by Zn.	Zinc	240-242	metallothionein 2	Mus musculus	179-184
3341018-6	1988	MT mRNAs increased to maximum levels 6-9 hr after Zn administration, at which times MT-II mRNA was about two times more abundant than MT-I mRNA.	Zinc	50-52	metallothionein 2	Mus musculus	84-89
3341018-13	1988	Thus, Zn treatment increases transcription of both MT-I and MT-II genes and the synthesis of MT-I and MT-II.	Zinc	6-8	metallothionein 1	Rattus norvegicus	51-55
3341018-13	1988	Thus, Zn treatment increases transcription of both MT-I and MT-II genes and the synthesis of MT-I and MT-II.	Zinc	6-8	metallothionein 2	Mus musculus	60-65
3341018-13	1988	Thus, Zn treatment increases transcription of both MT-I and MT-II genes and the synthesis of MT-I and MT-II.	Zinc	6-8	metallothionein 1	Rattus norvegicus	60-64
3341018-13	1988	Thus, Zn treatment increases transcription of both MT-I and MT-II genes and the synthesis of MT-I and MT-II.	Zinc	6-8	metallothionein 2	Mus musculus	102-107
3341018-14	1988	However, Zn-induced MT-II is more stable than MT-I.	Zinc	9-11	metallothionein 2	Mus musculus	20-25
3341018-14	1988	However, Zn-induced MT-II is more stable than MT-I.	Zinc	9-11	metallothionein 1	Rattus norvegicus	20-24
3341018-15	1988	These results suggest that differences in the rate of synthesis and degradation of MT-I and MT-II lead to a greater and more prolonged induction of MT-II following administration of Zn.	Zinc	182-184	metallothionein 1	Rattus norvegicus	83-87
3341018-15	1988	These results suggest that differences in the rate of synthesis and degradation of MT-I and MT-II lead to a greater and more prolonged induction of MT-II following administration of Zn.	Zinc	182-184	metallothionein 2	Mus musculus	92-97
3341018-15	1988	These results suggest that differences in the rate of synthesis and degradation of MT-I and MT-II lead to a greater and more prolonged induction of MT-II following administration of Zn.	Zinc	182-184	metallothionein 2	Mus musculus	148-153
3341019-10	1988	Additional experiments indicated that Cd (1-30 mumol/kg), Zn (100-3000 mumol/kg), and dexamethasone (0.3-10 mumol/kg) increased hepatic concentrations of MT-I and MT-II and their respective mRNAs in 14-day-old rats, despite the preexisting high levels of protein and mRNA at this time.	Zinc	58-60	metallothionein 1	Rattus norvegicus	154-158
3341019-10	1988	Additional experiments indicated that Cd (1-30 mumol/kg), Zn (100-3000 mumol/kg), and dexamethasone (0.3-10 mumol/kg) increased hepatic concentrations of MT-I and MT-II and their respective mRNAs in 14-day-old rats, despite the preexisting high levels of protein and mRNA at this time.	Zinc	58-60	metallothionein 2	Mus musculus	163-168
3341019-12	1988	In 14-day-old neonates, MT-I and MT-II genes are responsive to Cd, Zn, and dexamethasone when constitutive levels of both MT mRNA and isoproteins are high.	Zinc	67-69	metallothionein 1	Rattus norvegicus	24-28
3341019-12	1988	In 14-day-old neonates, MT-I and MT-II genes are responsive to Cd, Zn, and dexamethasone when constitutive levels of both MT mRNA and isoproteins are high.	Zinc	67-69	metallothionein 2	Mus musculus	33-38
3663161-1	1987	This study was undertaken to evaluate the effect of Zn and Cd pretreatment on the inhibition of delta-aminolaevulinic acid dehydratase (ALAD; porphobilinogen synthase, EC 4.2.1.24) by Pb.	Zinc	52-54	aminolevulinate dehydratase	Rattus norvegicus	96-134
3040753-18	1987	However, Hg2+, Zn2+, and Cu2+ inhibited both PLC-I and PLC-II, with PLC-II exhibiting much higher sensitivity to these metal ions than PLC-I.	Zinc	15-19	phospholipase C gamma 1	Bos taurus	55-61
3113788-0	1987	Induction of interferon-gamma in human leukocyte cultures stimulated by Zn2+.	Zinc	72-76	interferon gamma	Homo sapiens	13-29
3113788-5	1987	The type of interferon induced by Zn2+ was interferon-gamma, as proven by the use of specific antisera.	Zinc	34-38	interferon gamma	Homo sapiens	43-59
3311071-8	1987	2 Zn insulin crystals, when soaked in m-cresol containing solvents, are destroyed.	Zinc	2-4	insulin	Homo sapiens	5-12
3663161-1	1987	This study was undertaken to evaluate the effect of Zn and Cd pretreatment on the inhibition of delta-aminolaevulinic acid dehydratase (ALAD; porphobilinogen synthase, EC 4.2.1.24) by Pb.	Zinc	52-54	aminolevulinate dehydratase	Rattus norvegicus	136-140
3663161-1	1987	This study was undertaken to evaluate the effect of Zn and Cd pretreatment on the inhibition of delta-aminolaevulinic acid dehydratase (ALAD; porphobilinogen synthase, EC 4.2.1.24) by Pb.	Zinc	52-54	aminolevulinate dehydratase	Rattus norvegicus	142-166
3663161-3	1987	Pretreatment with Zn resulted in activation of hepatic and renal ALAD and attenuated the inhibition of this enzyme by Pb in vitro.	Zinc	18-20	aminolevulinate dehydratase	Rattus norvegicus	65-69
3663161-6	1987	The Pb IC50 (concentration causing half-maximal inhibition) values for hepatic and renal ALAD in Zn-pretreated rats and for hepatic ALAD in Cd-pretreated rats were increased above control, whereas the IC50 for renal ALAD in Cd-pretreated rats was unchanged.	Zinc	97-99	aminolevulinate dehydratase	Rattus norvegicus	89-93
3663161-10	1987	Thus liver and kidney Zn-thioneins and liver Cd,Zn-thionein with a low Cd/Zn ratio readily decrease the free pool of Pb available to interact with ALAD.	Zinc	22-24	aminolevulinate dehydratase	Rattus norvegicus	147-151
3306451-11	1987	These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule.	Zinc	108-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-44
3306451-11	1987	These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule.	Zinc	108-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	252-272
3031018-8	1987	Zn2+, a known potent inhibitor of rat liver bis(5"-adenosyl)-triphosphatase and bis(5"-guanosyl)-tetraphosphatase (EC 3.6 1.17), was without effect.	Zinc	0-4	fragile histidine triad diadenosine triphosphatase	Rattus norvegicus	44-75
3564038-5	1987	Zn (100-1000 mumol/kg) increased concentrations of MT-II about three times higher than MT-I, but higher dosages increased both isoforms to similar levels.	Zinc	0-2	metallothionein 1	Rattus norvegicus	51-55
2851035-1	1987	Previous structure-activity studies of captopril and related active angiotensin-converting enzyme (ACE) inhibitors have led to the conclusion that the basic structural requirements for inhibition of ACE involve (a) a terminal carboxyl group; (b) an amido carbonyl group; and (c) different types of effective zinc (Zn) ligand functional groups.	Zinc	314-316	angiotensin I converting enzyme	Homo sapiens	99-102
2851035-1	1987	Previous structure-activity studies of captopril and related active angiotensin-converting enzyme (ACE) inhibitors have led to the conclusion that the basic structural requirements for inhibition of ACE involve (a) a terminal carboxyl group; (b) an amido carbonyl group; and (c) different types of effective zinc (Zn) ligand functional groups.	Zinc	314-316	angiotensin I converting enzyme	Homo sapiens	199-202
2851035-5	1987	Consequently, by placing the carboxyl binding group, the binding site for amido carbonyl, and the Zn atom site in positions determined by ideal binding geometry with the inhibitors" functional groups, it was possible to clearly specify a geometry for the active site of ACE.	Zinc	98-100	angiotensin I converting enzyme	Homo sapiens	270-273
3564038-7	1987	However, with Zn treatment (1000 mumol/kg), MT-II levels were three times higher than MT-I at all times after 6 hr.	Zinc	14-16	metallothionein 1	Rattus norvegicus	44-48
3564038-9	1987	In pancreas, Zn (300-10,000 mumol/kg) induced MT-I and MT-II to similar levels.	Zinc	13-15	metallothionein 1	Rattus norvegicus	46-50
3564038-11	1987	However, Zn treatment preferentially increased hepatic MT-II at low dosages but induced MT-I and MT-II to similar levels at high dosages.	Zinc	9-11	metallothionein 1	Rattus norvegicus	55-59
3564038-12	1987	In contrast, Zn induced MT-I and MT-II to similar levels in kidney and pancreas.	Zinc	13-15	metallothionein 1	Rattus norvegicus	24-28
3496267-2	1987	Thymocyte activation by Zn++ required the presence of 2-mercaptoethanol (2-ME) and bacterial lipopolysaccharide (LPS) in concentrations as low as 1.0 ng/ml.	Zinc	24-28	toll-like receptor 4	Mus musculus	113-116
3813567-12	1987	The results demonstrate a dual function for Zn-thionein in mediating Pb inhibition of ALAD by a mechanism involving both donation of Zn to this Zn-requiring enzyme and chelation of Pb.	Zinc	133-135	aminolevulinate dehydratase	Rattus norvegicus	86-90
3593237-5	1987	Zn2+-induced changes in calregulin conformation and hydrophobicity monitored by intrinsic protein fluorescence and the hydrophobic fluorescent probe 8-anilino-1-naphthalenesulphonate were very similar, suggesting that the Zn2+-dependent increase in the hydrophobicity of bovine, rabbit and chicken calregulin was conserved.	Zinc	0-4	calreticulin	Bos taurus	24-34
3593237-5	1987	Zn2+-induced changes in calregulin conformation and hydrophobicity monitored by intrinsic protein fluorescence and the hydrophobic fluorescent probe 8-anilino-1-naphthalenesulphonate were very similar, suggesting that the Zn2+-dependent increase in the hydrophobicity of bovine, rabbit and chicken calregulin was conserved.	Zinc	0-4	calreticulin	Bos taurus	298-308
3813567-12	1987	The results demonstrate a dual function for Zn-thionein in mediating Pb inhibition of ALAD by a mechanism involving both donation of Zn to this Zn-requiring enzyme and chelation of Pb.	Zinc	44-46	aminolevulinate dehydratase	Rattus norvegicus	86-90
3813567-1	1987	This study was undertaken to evaluate the ability of kidney Zn-thionein to regulate Zn availability to the Zn-dependent enzyme, delta-aminolevulinic acid dehydratase (ALAD), and mediate the effect of Pb on this enzyme.	Zinc	60-62	aminolevulinate dehydratase	Rattus norvegicus	128-165
3813567-1	1987	This study was undertaken to evaluate the ability of kidney Zn-thionein to regulate Zn availability to the Zn-dependent enzyme, delta-aminolevulinic acid dehydratase (ALAD), and mediate the effect of Pb on this enzyme.	Zinc	60-62	aminolevulinate dehydratase	Rattus norvegicus	167-171
3813567-1	1987	This study was undertaken to evaluate the ability of kidney Zn-thionein to regulate Zn availability to the Zn-dependent enzyme, delta-aminolevulinic acid dehydratase (ALAD), and mediate the effect of Pb on this enzyme.	Zinc	84-86	aminolevulinate dehydratase	Rattus norvegicus	128-165
3813567-1	1987	This study was undertaken to evaluate the ability of kidney Zn-thionein to regulate Zn availability to the Zn-dependent enzyme, delta-aminolevulinic acid dehydratase (ALAD), and mediate the effect of Pb on this enzyme.	Zinc	84-86	aminolevulinate dehydratase	Rattus norvegicus	167-171
3813567-2	1987	Male CD rats were pretreated with 200 mumol Zn/kg, sc, 48 and 24 h prior to assay of renal ALAD, which resulted in activation of renal ALAD and increased the resistance of this enzyme to inhibition by Pb in vitro.	Zinc	44-46	aminolevulinate dehydratase	Rattus norvegicus	91-95
3813567-2	1987	Male CD rats were pretreated with 200 mumol Zn/kg, sc, 48 and 24 h prior to assay of renal ALAD, which resulted in activation of renal ALAD and increased the resistance of this enzyme to inhibition by Pb in vitro.	Zinc	44-46	aminolevulinate dehydratase	Rattus norvegicus	135-139
3813567-10	1987	Gel filtration of ALAD assay incubates containing 65Zn-thionein demonstrated that Zn is transferred from Zn-thionein to ALAD.	Zinc	52-54	aminolevulinate dehydratase	Rattus norvegicus	18-22
3813567-10	1987	Gel filtration of ALAD assay incubates containing 65Zn-thionein demonstrated that Zn is transferred from Zn-thionein to ALAD.	Zinc	52-54	aminolevulinate dehydratase	Rattus norvegicus	120-124
2435747-5	1987	The retentions of tRNAVal, tRNAIle, and tRNALys of E. coli and yeast tRNAPhe on RPC-5 were all markedly increased by Zn2+ ions.	Zinc	117-121	DNA-directed RNA polymerase core subunit RPC40	Saccharomyces cerevisiae S288C	80-85
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	30-33	insulin	Homo sapiens	155-162
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	30-34	insulin	Homo sapiens	155-162
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-46	insulin	Homo sapiens	155-162
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-46	insulin	Homo sapiens	319-326
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-45	insulin	Homo sapiens	155-162
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-45	insulin	Homo sapiens	319-326
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-46	insulin	Homo sapiens	155-162
3552036-2	1987	For [PAR]0 much greater than [Zn2+]0 and [Zn2+]/[In] less than or equal to 0.33, the reaction leads to the sequestering and ultimate removal of all of the insulin-bound Zn2+; for [Zn2+]0 much greater than [PAR]0, two stable ternary complexes are formed where Zn2+ has ligands derived from PAR as well as from hexameric insulin.	Zinc	42-46	insulin	Homo sapiens	319-326
3552036-7	1987	The faster step is first order in PAR and first order in insulin-bound Zn2+ (k congruent to 3 X 10(3) M-1 s-1) and involves the formation of an intermediate in which PAR is coordinated to insulin-bound zinc at the His-B10 site.	Zinc	71-75	insulin	Homo sapiens	57-64
3552036-7	1987	The faster step is first order in PAR and first order in insulin-bound Zn2+ (k congruent to 3 X 10(3) M-1 s-1) and involves the formation of an intermediate in which PAR is coordinated to insulin-bound zinc at the His-B10 site.	Zinc	71-75	insulin	Homo sapiens	188-195
3809168-6	1987	In addition, AAA and AOD tissue had low ascorbic acid levels and low Cu,Zn-SOD activity with Cu,Zn-SOD:Mn-SOD ratios of 0.27 and 0.19, respectively, compared to a ratio of 3.20 in control aorta.	Zinc	72-74	superoxide dismutase 1	Homo sapiens	75-78
3590083-2	1987	For any given level of fibrinogen (0.2-2.6 mg/ml), the relative fibrin turbidity of thrombin-induced clots increases with Zn(II) in a concentration dependent manner.	Zinc	122-128	coagulation factor II, thrombin	Homo sapiens	84-92
3024668-4	1986	The inhibition of kininase II activity in human plasma by FOY S 983 was due to its 6-guanidinocaproate component probably acting as Zn2+-complexing agent.	Zinc	132-136	angiotensin I converting enzyme	Homo sapiens	18-29
2951208-2	1986	Physical stabilization of neutral insulin solutions has been obtained by addition of two extra Zn2+ per hexamer of insulin.	Zinc	95-99	insulin	Homo sapiens	34-41
2951208-2	1986	Physical stabilization of neutral insulin solutions has been obtained by addition of two extra Zn2+ per hexamer of insulin.	Zinc	95-99	insulin	Homo sapiens	115-122
2951208-6	1986	It is concluded that neutral insulin solution can be physically stabilized by addition of extra Zn2+ without affecting other qualities of the insulin preparation including chemical stability, immunogenicity, and duration of action after injection.	Zinc	96-100	insulin	Homo sapiens	29-36
2959547-1	1987	A radioimmunoassay specific for metallothionein-I (MT-I) has been used for the estimation of this protein in various tissues of the rat following a single intraperitoneal injection of ZnSO4 (2 mg Zn/kg body weight).	Zinc	184-186	metallothionein 1	Rattus norvegicus	32-49
2959547-1	1987	A radioimmunoassay specific for metallothionein-I (MT-I) has been used for the estimation of this protein in various tissues of the rat following a single intraperitoneal injection of ZnSO4 (2 mg Zn/kg body weight).	Zinc	184-186	metallothionein 1	Rattus norvegicus	51-55
2959547-2	1987	Quantitative information has also been obtained about the rates of clearance of MT-I from selected tissues following Zn injection.	Zinc	117-119	metallothionein 1	Rattus norvegicus	80-84
2959547-5	1987	MT-I levels in the liver and pancreas increased several fold following Zn injection.	Zinc	71-73	metallothionein 1	Rattus norvegicus	0-4
2959552-3	1987	The mechanism of enzyme activation, as demonstrated using 65Zn-labeled thionein, involves direct transfer of Zn from Zn-thionein to ALAD.	Zinc	60-62	aminolevulinate dehydratase	Rattus norvegicus	132-136
3722381-3	1986	Zn++ was required for 125I-HMWK binding to unstimulated platelets and binding was maximal at 50 microM Zn++.	Zinc	0-4	kininogen 1	Homo sapiens	27-31
3768320-4	1986	A Zn(II) titration of Eu(III)-alpha-lactalbumin reconfirmed that both sites I and II can be occupied simultaneously [Musci, G., &amp; Berliner, L. J.	Zinc	2-4	lactalbumin alpha	Homo sapiens	30-47
3728455-1	1986	Physiologic concentrations of Zn(II) (4-40 microM) can increase the rate of thrombin-induced fibrin clot formation (decreased clotting time, CT) and increase the turbidity of the fibrin gel.	Zinc	30-36	coagulation factor II, thrombin	Homo sapiens	76-84
3728455-5	1986	Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II).	Zinc	90-92	coagulation factor II, thrombin	Homo sapiens	40-48
3728455-5	1986	Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II).	Zinc	90-92	fibrinogen beta chain	Homo sapiens	63-73
3728455-5	1986	Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II).	Zinc	155-157	coagulation factor II, thrombin	Homo sapiens	40-48
3728455-5	1986	Radioimmunoassay for FPA indicates that thrombin activation of fibrinogen is decreased by Zn(II), with 50% inhibition of FPA release observed at 35 microM Zn(II).	Zinc	155-157	fibrinogen beta chain	Homo sapiens	63-73
3533813-4	1986	studies at 270 MHz were made of the transformation of 2 Zn insulin hexamer to 4 Zn hexamer produced by the addition of anions (thiocyanate ion).	Zinc	56-58	insulin	Homo sapiens	59-66
3533813-4	1986	studies at 270 MHz were made of the transformation of 2 Zn insulin hexamer to 4 Zn hexamer produced by the addition of anions (thiocyanate ion).	Zinc	80-82	insulin	Homo sapiens	59-66
3533813-9	1986	Addition of SCN- to Zn-free insulin (mainly dimer) produced only a small transformation, consistent with the idea that Zn2+ promotes formation of hexamer from dimer but probably does not otherwise affect the transformation.	Zinc	20-22	insulin	Homo sapiens	28-35
3533813-9	1986	Addition of SCN- to Zn-free insulin (mainly dimer) produced only a small transformation, consistent with the idea that Zn2+ promotes formation of hexamer from dimer but probably does not otherwise affect the transformation.	Zinc	119-123	insulin	Homo sapiens	28-35
3722179-1	1986	Scatchard analysis of equilibrium dialysis studies have revealed that in the presence of 3.0 mM MgCl2 and 150 mM KCl, calregulin has a single binding site for Ca2+ with an apparent dissociation constant (apparent Kd) of 0.05 microM and 14 binding sites for Zn2+ with apparent Kd(Zn2+) of 310 microM.	Zinc	257-261	calreticulin	Homo sapiens	118-128
3722179-1	1986	Scatchard analysis of equilibrium dialysis studies have revealed that in the presence of 3.0 mM MgCl2 and 150 mM KCl, calregulin has a single binding site for Ca2+ with an apparent dissociation constant (apparent Kd) of 0.05 microM and 14 binding sites for Zn2+ with apparent Kd(Zn2+) of 310 microM.	Zinc	279-283	calreticulin	Homo sapiens	118-128
3722179-3	1986	Zn2+ binding to calregulin causes a dose-dependent increase of about 250% in its intrinsic fluorescence intensity and a red shift in the emission maximum of about 11 nm.	Zinc	0-4	calreticulin	Homo sapiens	16-26
3722179-4	1986	Half-maximal wavelength shift occurs at 0.4 mol of Zn2+/mol of calregulin, and 100% of the wavelength shift is complete at 2 mol of Zn2+/mol of calregulin.	Zinc	51-55	calreticulin	Homo sapiens	63-73
3722179-4	1986	Half-maximal wavelength shift occurs at 0.4 mol of Zn2+/mol of calregulin, and 100% of the wavelength shift is complete at 2 mol of Zn2+/mol of calregulin.	Zinc	132-136	calreticulin	Homo sapiens	63-73
3722179-4	1986	Half-maximal wavelength shift occurs at 0.4 mol of Zn2+/mol of calregulin, and 100% of the wavelength shift is complete at 2 mol of Zn2+/mol of calregulin.	Zinc	132-136	calreticulin	Homo sapiens	144-154
3722179-6	1986	Half-maximal Zn2+-induced shift in ANS emission maximum occurred at 1.2 mol of Zn2+/mol of calregulin, and 100% of this shift occurred at 6 mol of Zn2+/mol of calregulin.	Zinc	13-17	calreticulin	Homo sapiens	91-101
3722179-6	1986	Half-maximal Zn2+-induced shift in ANS emission maximum occurred at 1.2 mol of Zn2+/mol of calregulin, and 100% of this shift occurred at 6 mol of Zn2+/mol of calregulin.	Zinc	13-17	calreticulin	Homo sapiens	159-169
3722179-7	1986	Of 12 cations tested, only Zn2+ and Ca2+ produced changes in calregulin intrinsic fluorescence, and none of these metal ions could inhibit the Zn2+-induced red shift in intrinsic fluorescence emission maximum.	Zinc	27-31	calreticulin	Homo sapiens	61-71
3722179-9	1986	These results suggest that calregulin contains distinct and specific ligand-binding sites for Ca2+ and Zn2+.	Zinc	103-107	calreticulin	Homo sapiens	27-37
3791046-2	1986	Zn pretreatment increased the hepatic MT concentrations markedly and reduced the magnitudes of the CCl4-induced reduction of cytochrome P450 concentration as well as elevation of serum alanine aminotransferase and aspartate aminotransferase activities when determined at 4 or 24 h following CCl4 treatment.	Zinc	0-2	C-C motif chemokine ligand 4	Rattus norvegicus	99-103
3791046-2	1986	Zn pretreatment increased the hepatic MT concentrations markedly and reduced the magnitudes of the CCl4-induced reduction of cytochrome P450 concentration as well as elevation of serum alanine aminotransferase and aspartate aminotransferase activities when determined at 4 or 24 h following CCl4 treatment.	Zinc	0-2	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	214-240
3791046-2	1986	Zn pretreatment increased the hepatic MT concentrations markedly and reduced the magnitudes of the CCl4-induced reduction of cytochrome P450 concentration as well as elevation of serum alanine aminotransferase and aspartate aminotransferase activities when determined at 4 or 24 h following CCl4 treatment.	Zinc	0-2	C-C motif chemokine ligand 4	Rattus norvegicus	291-295
3791046-3	1986	Treatment of Zn-exposed animals with CCl4 also resulted in significant reduction of the concentrations of hepatic MT (as determined by the cadmium-saturation method) as well as cytosolic Zn.	Zinc	13-15	C-C motif chemokine ligand 4	Rattus norvegicus	37-41
3791046-3	1986	Treatment of Zn-exposed animals with CCl4 also resulted in significant reduction of the concentrations of hepatic MT (as determined by the cadmium-saturation method) as well as cytosolic Zn.	Zinc	187-189	C-C motif chemokine ligand 4	Rattus norvegicus	37-41
3791046-4	1986	Sephadex G-75 chromatographic study of hepatic cytosols showed that MT-bound Zn was selectively depleted by CCl4 exposure.	Zinc	77-79	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
3791046-5	1986	Moreover, it was demonstrated that CCl4, after metabolic activation, reduced the cadmium binding capacity of Zn-induced hepatic MT in vitro.	Zinc	109-111	C-C motif chemokine ligand 4	Rattus norvegicus	35-39
3722381-3	1986	Zn++ was required for 125I-HMWK binding to unstimulated platelets and binding was maximal at 50 microM Zn++.	Zinc	103-107	kininogen 1	Homo sapiens	27-31
3521884-7	1986	S-100 binds Zn2+ with high affinity.	Zinc	12-16	S100 calcium binding protein A1	Homo sapiens	0-5
3006777-2	1986	No disturbance of the EPR signal of the tubulin-bound allocolchicine spin probe could be observed at room temperature in the presence of other paramagnetic probes: Mn(II) for the binding site of Mg(II), Co(II) for the Zn(II) binding site and Cr(III)GTP for the binding site of the exchangeable GTP.	Zinc	218-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
2431677-5	1986	Both histamine and Zn2+, two ingredients of mast-cell granules, strongly inhibit DPP II at concentrations reported to occur in the granules.	Zinc	19-23	dipeptidylpeptidase 7	Rattus norvegicus	81-87
2939070-0	1986	Zn2+-dependent reversible inactivation of rat liver phosphofructokinase-1.	Zinc	0-4	phosphofructokinase, liver type	Rattus norvegicus	52-73
2939070-10	1986	A direct Zn2+-dependent binding of phosphofructokinase-1 to the inactivating protein has been demonstrated in experiments with matrix-bound phosphofructokinase-1 inactivating protein.	Zinc	9-13	phosphofructokinase, liver type	Rattus norvegicus	35-56
2939070-10	1986	A direct Zn2+-dependent binding of phosphofructokinase-1 to the inactivating protein has been demonstrated in experiments with matrix-bound phosphofructokinase-1 inactivating protein.	Zinc	9-13	phosphofructokinase, liver type	Rattus norvegicus	140-161
4074699-2	1985	Addition of Zn2+ reactivates it completely, and reconstitution with Co2+, Ni2+, or Cu2+ results in a 5.0-, 9.8-, and 10-fold more active enzyme than native aminopeptidase, respectively.	Zinc	12-16	carboxypeptidase Q	Homo sapiens	156-170
2999330-2	1985	Some new derivatives of Co(II), Co(III), Ni(II), Cu(II), and Zn(II) with 5" AMP have been obtained, characterized by elemental analysis, infrared, electronic, and fluorescence spectroscopy.	Zinc	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
3028067-7	1986	The inhibitor of Zn-containing metalloproteases 2-(N-hydroxycarboxamido)-4-methylpentanoyl-L-alanylglycin e amide) (Zinkov) selectively inhibited ACE from blood plasma, whereas ACE from seminal plasma was not influenced.	Zinc	17-19	angiotensin I converting enzyme	Homo sapiens	146-149
3028067-7	1986	The inhibitor of Zn-containing metalloproteases 2-(N-hydroxycarboxamido)-4-methylpentanoyl-L-alanylglycin e amide) (Zinkov) selectively inhibited ACE from blood plasma, whereas ACE from seminal plasma was not influenced.	Zinc	17-19	angiotensin I converting enzyme	Homo sapiens	177-180
3959350-1	1986	The effects of the Ca2+, Mg2+, Zn2+, Cd2+, Hg2+ and Mn2+ on the conformation of calmodulin (CaM) have been tested by using 400 MHz 1H NMR.	Zinc	31-35	calmodulin 1	Homo sapiens	80-90
3959350-1	1986	The effects of the Ca2+, Mg2+, Zn2+, Cd2+, Hg2+ and Mn2+ on the conformation of calmodulin (CaM) have been tested by using 400 MHz 1H NMR.	Zinc	31-35	calmodulin 1	Homo sapiens	92-95
3959350-2	1986	In the aromatic region of the spectrum of CaM with a one molar ratio of cation per CaM, Zn2+, Cd2+, Hg2+ and Mn2+ induced spectral changes which were very similar to those seen for Ca2+.	Zinc	88-92	calmodulin 1	Homo sapiens	42-45
3959350-2	1986	In the aromatic region of the spectrum of CaM with a one molar ratio of cation per CaM, Zn2+, Cd2+, Hg2+ and Mn2+ induced spectral changes which were very similar to those seen for Ca2+.	Zinc	88-92	calmodulin 1	Homo sapiens	83-86
4066663-8	1985	These studies suggest that some metals including La3+, Tb3+, Pb2+, Cd2+, Zn2+ and protons are capable of binding to a calcium-calmodulin complex and forming an allosterically active species of calmodulin which cannot be maintained by physiological concentrations of calcium ions alone.	Zinc	73-76	calmodulin 1	Homo sapiens	126-136
4066663-8	1985	These studies suggest that some metals including La3+, Tb3+, Pb2+, Cd2+, Zn2+ and protons are capable of binding to a calcium-calmodulin complex and forming an allosterically active species of calmodulin which cannot be maintained by physiological concentrations of calcium ions alone.	Zinc	73-76	calmodulin 1	Homo sapiens	193-203
4026862-1	1985	The transition-state-analog inhibitor, 1-butaneboronic acid, markedly enhances the uptake of one g-atom of Zn2+ ions from a metal ion buffer system by Zn-depleted Aeromonas aminopeptidase.	Zinc	107-111	carboxypeptidase Q	Homo sapiens	173-187
4026862-1	1985	The transition-state-analog inhibitor, 1-butaneboronic acid, markedly enhances the uptake of one g-atom of Zn2+ ions from a metal ion buffer system by Zn-depleted Aeromonas aminopeptidase.	Zinc	107-109	carboxypeptidase Q	Homo sapiens	173-187
3890940-5	1985	Substitution of Co(II) for Zn(II) causes a decrease in the Eu(III) fluorescence lifetime.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
3910325-7	1985	Two subjects manifested a negative lymphocyte response to porcine insulin (2 ZN) with strongly positive response to zinc-free porcine insulin; this suggests that immunogenic determinants may reside in physical characteristics of the insulin molecule rather than in the amino acid sequence.	Zinc	77-79	insulin	Homo sapiens	66-73
4003387-1	1985	The influence of Zn+2 on fibrin clot formation was investigated by measuring its effect on the clotting times of fibrinogen exposed to thrombin.	Zinc	17-21	coagulation factor II, thrombin	Homo sapiens	135-143
4003387-4	1985	Higher levels of Zn+2 (greater than 0.2 mM final concentration) were required to accelerate thrombin-induced clot formation in the presence of citrate or oxalate.	Zinc	17-21	coagulation factor II, thrombin	Homo sapiens	92-100
4003387-7	1985	As an extension of these findings, we examined the effect of Zn+2 on the inhibition of thrombin by antithrombin-III (AT-III).	Zinc	61-65	coagulation factor II, thrombin	Homo sapiens	87-95
4003387-8	1985	The presence of as little as 0.006 mM Zn+2 in an incubating mixture of thrombin and AT-III severely reduced the inhibitory activity of AT-III towards thrombin.	Zinc	38-42	coagulation factor II, thrombin	Homo sapiens	71-79
4003387-8	1985	The presence of as little as 0.006 mM Zn+2 in an incubating mixture of thrombin and AT-III severely reduced the inhibitory activity of AT-III towards thrombin.	Zinc	38-42	coagulation factor II, thrombin	Homo sapiens	150-158
4003387-9	1985	It was observed that the relative intrinsic fluorescence emission of human thrombin decreased upon exposure to Zn+2 but was unaffected by Mg+2 or Mn+2.	Zinc	111-113	coagulation factor II, thrombin	Homo sapiens	75-83
4003387-10	1985	It is suggested that Zn+2 can form a complex with thrombin, which results in altered reactivity towards fibrinogen and decreased inhibition by AT-III.	Zinc	21-25	coagulation factor II, thrombin	Homo sapiens	50-58
2860921-1	1985	Substitution of Cd2+ for Zn2+ yields a hexameric insulin species containing 3 mol of metal ion per hexamer.	Zinc	25-29	insulin	Homo sapiens	49-56
3995083-5	1985	Also, incubation of 65Zn-albumin in the presence of excess Mn2+ (1 mM) did not result in the displacement of Zn from albumin or Mn binding.	Zinc	22-24	albumin	Homo sapiens	25-32
4039320-10	1985	Additionally, the possible physiological significance of the inhibition of insulin receptor kinase by Zn2+ is discussed in light of the fact that Zn2+ is accumulated in and secreted from pancreatic islet cells together with insulin.	Zinc	102-106	insulin	Homo sapiens	75-82
4039320-10	1985	Additionally, the possible physiological significance of the inhibition of insulin receptor kinase by Zn2+ is discussed in light of the fact that Zn2+ is accumulated in and secreted from pancreatic islet cells together with insulin.	Zinc	102-106	insulin	Homo sapiens	224-231
4039320-10	1985	Additionally, the possible physiological significance of the inhibition of insulin receptor kinase by Zn2+ is discussed in light of the fact that Zn2+ is accumulated in and secreted from pancreatic islet cells together with insulin.	Zinc	146-150	insulin	Homo sapiens	75-82
3157790-6	1985	The changes in ADH activities were accompanied by changes in the hepatic Zn content.	Zinc	73-75	aldo-keto reductase family 1 member A1	Rattus norvegicus	15-18
3890940-6	1985	Calculations based on Forster energy-transfer theory predict that the Co(II) [or Zn(II) in vivo] and Eu(III) [or Ca(II) in vivo] binding sites are separated by 9.6 +/- 0.5 A.	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
3890452-5	1985	Divalent cations, Ca++ and Zn++ selectively enhanced insulin degradation by the membranous fractions, and Cu++ and Zn++ strongly inhibited insulin degradation by all the erythrocyte fractions.	Zinc	27-31	insulin	Homo sapiens	53-60
3884821-0	1985	Simulation of conformational changes in 2 Zn insulin.	Zinc	42-44	insulin	Homo sapiens	45-52
3890452-5	1985	Divalent cations, Ca++ and Zn++ selectively enhanced insulin degradation by the membranous fractions, and Cu++ and Zn++ strongly inhibited insulin degradation by all the erythrocyte fractions.	Zinc	115-119	insulin	Homo sapiens	139-146
6322852-4	1984	This behaviour suggests that cobalt in Co,Zn-superoxide dismutase is open to solvent access, at variance with the Co(II) of the Cu,Co-superoxide dismutase, which is substituted for the Zn.	Zinc	42-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-120
3868358-2	1985	The salts of Co, Cd and Zn (when given repeatedly for one month in subtoxic doses) shortened the duration of hexobarbital sleeping time, increased the activities of Ethylmorphine-N-demethylase (EMD) and Benzphetamine-N-demethylase (BND), and the cytochrome P-450 and heme contents.	Zinc	24-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	246-262
3841804-8	1985	Trivial reasons for inhibition, for example, inactivation of xanthine oxidase or complex formation with O2-, were ruled out by showing that the rate of reduction of cytochrome c by xanthine/xanthine oxidase is not affected by Zn(II).	Zinc	226-228	cytochrome c, somatic	Homo sapiens	165-177
3966243-10	1985	[square root Zn.SH/ALA-D subunit]2 + 0.0898..[square root Zn.SH/ALA-D subunit] + 33.6 (multiple correlation coefficient = 0.909, n = 108, p less than 0.01).	Zinc	13-15	aminolevulinate dehydratase	Rattus norvegicus	19-24
6375675-6	1984	It is inhibited by Co2+, Zn2+ and Mn2+ but is stimulated by Fe2+, deoxycholate and phospholipase A2.	Zinc	25-29	phospholipase A2 group IB	Homo sapiens	83-99
6722240-6	1984	In the presence of 1.0 mM added CaCl2, phospholipase A2 activity was inhibited by Zn2+ and Mn2+; whereas Cu2+, Cd2+, Mg2+, or Sr2+ had no effect.	Zinc	82-86	phospholipase A2 group IB	Homo sapiens	39-55
3919690-2	1985	The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 and microsomal heme.	Zinc	25-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	98-114
6487634-6	1984	Most of the Zn2+-induced conformational changes occurred after the binding of two zinc ions per mole of S100b protein.	Zinc	12-16	S100 calcium binding protein B	Homo sapiens	104-109
6487634-9	1984	These results indicated that the Ca2+- and Zn2+-binding sites on S100b protein are different and suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium.	Zinc	43-47	S100 calcium binding protein B	Homo sapiens	65-70
6487634-9	1984	These results indicated that the Ca2+- and Zn2+-binding sites on S100b protein are different and suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium.	Zinc	110-114	S100 calcium binding protein B	Homo sapiens	65-70
6086614-13	1984	Atomic absorption spectroscopy revealed nearly stoichiometric amounts of tightly bound Fe and Zn (but little other ions) on purified calcineurin, which remained bound during the calmodulin-dependent deactivation; removal of tightly bound metals is, therefore, not the cause of deactivation.	Zinc	94-96	calmodulin 1	Homo sapiens	178-188
6086614-15	1984	In addition to the nondissociable Zn and Fe and the Ca2+ bound to the B subunit and calmodulin, the enzyme requires a divalent metal ion for structural stability and full activity.	Zinc	34-36	calmodulin 1	Homo sapiens	70-94
6424572-11	1984	The enzyme was inhibited by Zn2+, Fe2+, Hg2+, and sulfhydryl blockers such as 5,5"-dithiobis(2-nitrobenzoic acid), p-hydroxymercuribenzoate, and iodoacetate, apparently due to their reaction with one out of six titratable sulfhydryl groups per mole of acrosin.	Zinc	28-32	acrosin	Oryctolagus cuniculus	252-259
6722240-9	1984	The significance of human sperm phospholipase A2 activity and its modulation by Ca2+, Zn2+ and Mn2+ in the sperm acrosome reaction is discussed.	Zinc	86-90	phospholipase A2 group IB	Homo sapiens	32-48
6581526-6	1983	Using nuclear tracer technique quantitative measurements of the corroded material from samples exposed to cyclic loading showed the dispersed non-gamma 2 amalgam to release more Hg, Cu and Zn than the two gamma 2-containing amalgams and that 50-90% copper and mercury were present as particulate matter.	Zinc	189-191	tryptophanyl-tRNA synthetase 1	Homo sapiens	146-153
6717431-7	1984	The results indicate that although Zn, Cu, Hg, Ag, Co, Ni, and Bi induce metallothionein-I mRNA accumulation in both Cdr80 and Cds cells, the Cdr80 cells show increased resistance to only a subset of these metals (Zn, Cu, Hg, and Bi).	Zinc	35-37	metallothionein 1	Mus musculus	73-90
6697238-3	1984	50 microM Zn2+ also reversibly inhibited prolactin secretion stimulated by either 50 mM K+ or 10 nM TRH, but the secretion of GH, TSH and LH which was stimulated by 50 mM K+ or stimulation of TSH by 10 nM TRH was not inhibited.	Zinc	10-14	prolactin	Rattus norvegicus	41-50
6321177-9	1984	This feature could mean that optimal binding of the Zn atom present in the catalytic site is a more stringent requirement in angiotensin-converting enzyme than in enkephalinase.	Zinc	52-54	angiotensin I converting enzyme	Rattus norvegicus	125-154
6088316-5	1984	Bivalent cations [Mg(II), Mn(II) or Ca(II)] were required for activity, but Zn(II) was a competitive inhibitor (Ki = 5 microM).	Zinc	76-82	carbonic anhydrase 2	Rattus norvegicus	36-42
6363174-1	1983	X-ray studies on semi-synthetic human insulin have shown that it crystallizes in the rhombohedral space group R3 and is nearly isomorphous with 2 Zn pig insulin.	Zinc	146-148	insulin	Homo sapiens	38-45
6615809-5	1983	These results indicate that at serum bicarbonate concentrations, transferrin should have a higher affinity for zinc(II) than serum albumin and therefore could play some role in zinc transport.	Zinc	111-119	transferrin	Homo sapiens	65-76
6641944-1	1983	The homologous proteins S-100a and S-100b affect the microtubule system in a distinctly different way in the presence of low molar ratios of Zn2+.	Zinc	141-145	S100 calcium binding protein A1	Homo sapiens	24-30
6641944-1	1983	The homologous proteins S-100a and S-100b affect the microtubule system in a distinctly different way in the presence of low molar ratios of Zn2+.	Zinc	141-145	S100 calcium binding protein B	Homo sapiens	35-41
6641944-3	1983	Higher molar ratios per S-100b (greater than 4) potentiate the general Zn2+ effect, promoting the formation of sheets of microtubules.	Zinc	71-75	S100 calcium binding protein B	Homo sapiens	24-30
6641944-4	1983	However, the effect of S-100a is quite different, no inhibition of assembly can be observed and the presence of S-100a seems to protect the microtubule proteins against the effect of Zn2+ by chelating the Zn2+ and decreasing the free metal-ion concentration.	Zinc	183-187	S100 calcium binding protein A1	Homo sapiens	112-118
6641944-4	1983	However, the effect of S-100a is quite different, no inhibition of assembly can be observed and the presence of S-100a seems to protect the microtubule proteins against the effect of Zn2+ by chelating the Zn2+ and decreasing the free metal-ion concentration.	Zinc	205-209	S100 calcium binding protein A1	Homo sapiens	112-118
6641944-5	1983	S-100a or S-100b cannot bind to the microtubule polymer-form, either in the absence or in the presence of Zn2+.	Zinc	106-110	S100 calcium binding protein A1	Homo sapiens	0-6
6658820-1	1983	The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats.	Zinc	159-161	parathyroid hormone	Rattus norvegicus	99-118
6658820-2	1983	This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supporting the hypothesis that the effect of Zn administration on bone may be mediated by parathyroid hormone.	Zinc	179-181	parathyroid hormone	Rattus norvegicus	100-119
6658820-2	1983	This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supporting the hypothesis that the effect of Zn administration on bone may be mediated by parathyroid hormone.	Zinc	179-181	parathyroid hormone	Rattus norvegicus	224-243
6626154-9	1983	The same effect on the u.v.-absorption spectrum of Ret-P was also induced by Co(II), Cr(II), Zn(II) and Fe(II), but not by Mg2+ or Cu(II).	Zinc	93-99	ret proto-oncogene	Rattus norvegicus	51-54
6615509-2	1983	Calmodulin is characterized by two sets of Zn2+ binding sites, with KD ranging from 8.10(-5)M to 3.10(-4)M. The S100b protein also exhibited two sets of zinc binding sites, with a much higher affinity.	Zinc	43-47	calmodulin 1	Homo sapiens	0-10
6615509-2	1983	Calmodulin is characterized by two sets of Zn2+ binding sites, with KD ranging from 8.10(-5)M to 3.10(-4)M. The S100b protein also exhibited two sets of zinc binding sites, with a much higher affinity.	Zinc	43-47	S100 calcium binding protein B	Homo sapiens	112-117
6615509-3	1983	KD = 10(-7) - 10(-6)M. We suggest that S100b protein should no longer be considered only as a "calcium binding protein" but also as a "zinc binding protein", and that Zn2+ ions are involved in the functions of the S100 proteins.	Zinc	167-171	S100 calcium binding protein B	Homo sapiens	39-44
7140742-5	1982	Zn2+ ions were shown to bind to calmodulin and affect the exchange rates of Ca2+ and Cd2+ for all four sites.	Zinc	0-4	calmodulin	Bos taurus	32-42
6615779-11	1983	While either conformer of alpha-lactalbumin [Ca(II) or Zn(II)] is kinetically equivalent, the Ca(II) form probably dominates under physiological conditions.	Zinc	55-61	lactalbumin alpha	Homo sapiens	26-43
6308919-7	1983	The levels of c-AMP in serum and urine were markedly increased in Zn-deficient rats in comparison with both control groups.	Zinc	66-68	cathelicidin antimicrobial peptide	Rattus norvegicus	14-19
6409077-11	1983	Induction of ovarian 20 alpha-hydroxysteroid dehydrogenase activity was delayed by about 8 h by Zn deficiency.	Zinc	96-98	aldo-keto reductase family 1, member C3	Rattus norvegicus	21-58
7152019-3	1982	The principle of this method is based on the fact that S100b protein becomes highly hydrophobic upon Zn2+ binding, whereas S100a and S100a" are not affected.	Zinc	101-105	S100 calcium binding protein B	Homo sapiens	55-60
6293548-1	1982	We have previously described a phosphotyrosylprotein phosphatase in membrane vesicles from human epidermoid carcinoma A431 cells which is inhibited by micromolar concentration of Zn2+ and is insensitive to ethylenediaminetetraacetic acid (EDTA) and NaF [Brautigan, D. L., Bornstein, P., &amp; Gallis, B.	Zinc	179-183	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
6293548-9	1982	The phosphatase was inhibited by Zn2+ at micromolar concentrations (K0.5 with EGF receptor kinase = 5 X 10(-6) M; with CM-SC phosphorylase = 3.3 X 10(-5) M) but not by millimolar concentrations of EDTA and NaF.	Zinc	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
7149855-5	1982	Oral Zn seems to improve the conversion of A to T and also uncovered the possibility that plasma PRL levels greater than 100 ng/ml might cause a blockade in the 5 alfa-reductase.	Zinc	5-7	prolactin	Homo sapiens	97-100
6957870-7	1982	The presence of Zn in synthetic FTS was confirmed by atomic absorption spectrometry.	Zinc	16-18	AKT interacting protein	Homo sapiens	32-35
6815172-3	1982	The inhibition by Zn2+ was competitive with both bicarbonate and H-protein and non-competitive with glycine.	Zinc	18-22	glycine cleavage system protein H	Gallus gallus	65-74
6815172-4	1982	Of the two reactions involved in the glycine-CO2 exchange, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety was not significantly affected by 100 microM Zn2+ or Cu2+, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine was strongly inhibited by either Zn2+ or Cu2+.	Zinc	179-183	glycine cleavage system protein H	Gallus gallus	99-108
6815172-4	1982	Of the two reactions involved in the glycine-CO2 exchange, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety was not significantly affected by 100 microM Zn2+ or Cu2+, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine was strongly inhibited by either Zn2+ or Cu2+.	Zinc	302-306	glycine cleavage system protein H	Gallus gallus	99-108
6957870-8	1982	The interaction between Zn and FTS was further suggested by microanalysis demonstrating the presence of this metal in thymic reticuloepithelial cells.	Zinc	24-26	AKT interacting protein	Homo sapiens	31-34
6810775-6	1982	Our results suggest a diminished A-to-T conversion and point to the possible role of Zn in the enzyme activity of the 17 beta-hydroxysteroid dehydrogenase.	Zinc	85-87	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	118-154
6127784-6	1982	Instead, Zn2+ and Co2+ reactivated the PPiase, indicating they might act as cofactors for the enzyme.	Zinc	9-13	FKBP prolyl isomerase 1B	Homo sapiens	39-45
6818357-4	1982	In rats pretreated with phenobarbital (0.05%), Zn (10 mg/l) and Cu (10 mg/l) in tap water and cysteine (200 mg/kg s.c.), fetal toxicity of ASA was reduced, whereas it was enhanced in rats pretreated with SKF-525A (200 mg/kg s.c.) and alpha-naphthyl acetic acid (200 mg/kg p.o.)	Zinc	47-49	nuclear RNA export factor 1	Rattus norvegicus	80-83
7333276-5	1981	Circular dichroism spectra suggest that elimination of Zn2+ ions affects the tertiary rather than the secondary structure of the tryptophanyl-tRNA synthetase.	Zinc	55-59	tryptophanyl-tRNA synthetase 1	Bos taurus	129-157
7115346-5	1982	Metallothioneins-I and -II were identified in parenchymal cells and non-parenchymal cells from Zn2+-treated rats.	Zinc	95-99	metallothionein 1	Rattus norvegicus	0-26
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	75-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
7197555-6	1981	Demetallized preparations of soybean lectin can be fully reactivated by dialysis against solutions containing Mn2+, Zn2+ or Cd2+.	Zinc	116-120	LOW QUALITY PROTEIN: lectin	Glycine max	37-43
7300822-1	1981	By means of atomic absorption spectroscopy up to 0.9 Zn2+ atom per molecule of bovine tryptophanyl-tRNA-synthetase (E. C. 6.1.1.2) was found.	Zinc	53-57	tryptophanyl-tRNA synthetase 1	Bos taurus	86-114
7300822-3	1981	Kinetic analysis of the inhibiting action of orthophenanthroline at various concentrations of tryptophan, ATP and tRNA leads to the conclusion that removal of Zn2+ prevents the binding of the ATP molecule to tryptophanyl-tRNA-synthetase.	Zinc	159-163	tryptophanyl-tRNA synthetase 1	Bos taurus	208-236
7240167-1	1981	Administration of Cd, Zn, Cu, or Hg increases the rate of transcription from the metallothionein-I gene in mouse liver and kidney.	Zinc	22-24	metallothionein 1	Mus musculus	81-98
6117474-2	1981	4 or 20 micrograms/100 g of cyclic somatostatin and 4 micrograms/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study.	Zinc	90-92	somatostatin	Mus musculus	99-111
6894538-6	1980	The Zn2+ blockade of Cd2+ induction was examined in detail, and prior or simultaneous administration of Zn2+ was found to be effective in blocking the induction of haem oxygenase and the concomitant decreases in cytochrome P-450 and haem contents, ethylmorphine demethylase activity and the sequential changes in delta-aminolaevulinate synthase activity.	Zinc	104-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	212-228
6969292-5	1980	Competition between Zn(II) and Co(II) for the first metal binding site suggests a value of 0.7 microM (pH 6.0, 30 degrees C, 1 M NaCl) for the dissociation constant of Zn(II).	Zinc	168-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
7339737-5	1981	Correcting copper levels in the Zn-group, by copper injection, restored the ceruloplasmin level.	Zinc	32-34	ceruloplasmin	Gallus gallus	76-89
6167283-7	1981	When the relative abilities of human albumin and apotransferrin to compete for Zn with low-molecular-weight chelators were compared at the same relative concentrations of these proteins as are found in plasma, albumin retained substantially more Zn then transferrin.	Zinc	79-81	transferrin	Homo sapiens	52-63
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
6821370-4	1980	The binding of Co(II) at the first site is much weaker than the binding of Zn(II) at this site, whereas the binding of Co(II) at the second site is tighter than the binding of Zn(II).	Zinc	176-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-125
32482-12	1978	EDTA which did not affect the enzyme activity has effect on enzyme stability similar to Zn.2+ Seminal alpha-mannosidase is not a zinc metalloenzyme but is activated by Zn2+.	Zinc	88-90	lysosomal alpha-mannosidase	Capra hircus	102-119
7369157-4	1980	When the zinc content of these milks was raised by adding Zn2+ in vitro, chromatography of milk from both species revealed the presence of zinc with the low molecular weight fractions.	Zinc	58-62	Weaning weight-maternal milk	Bos taurus	31-35
480340-6	1979	It is concluded that these action potentials are generated by Zn ions permeating Ca channels in snail neuronal membrane.	Zinc	62-64	snail family transcriptional repressor 1	Homo sapiens	96-101
223769-6	1979	While there are in vitro differences in the sensitivity of thymidine kinase and thymidylate kinase towards Cd2+-, Zn2%- and Cu2+-ions, both enzymes are equally depressed following their in vivo administration.	Zinc	114-118	deoxythymidylate kinase	Rattus norvegicus	80-98
574774-2	1979	Spectra of zinc-free insulin titrated with Zn2+ are unchanged after the addition of 1 equiv of zinc per insulin hexamer, indicating that the conformation of the hexamer is fixed at this point and that the second zinc ion does not significantly change the conformation.	Zinc	43-47	insulin	Homo sapiens	21-28
32482-12	1978	EDTA which did not affect the enzyme activity has effect on enzyme stability similar to Zn.2+ Seminal alpha-mannosidase is not a zinc metalloenzyme but is activated by Zn2+.	Zinc	168-172	lysosomal alpha-mannosidase	Capra hircus	102-119
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Zinc	204-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
83864-2	1978	spectra of Zn-insulin with Zn2+-free insulin demonstrated significant differences.	Zinc	27-31	insulin	Homo sapiens	14-21
83864-4	1978	The effect of Zn2+ on the immunological activity of insulin indicated that the antigenic determinants of insulin were also altered.	Zinc	14-18	insulin	Homo sapiens	52-59
83864-4	1978	The effect of Zn2+ on the immunological activity of insulin indicated that the antigenic determinants of insulin were also altered.	Zinc	14-18	insulin	Homo sapiens	105-112
83864-6	1978	The immunological activity of Zn-insulin and Zn2+-free insulin was compared in both the radioimmune and immune haemolysis-inhibition assays by using an identical population of antibodies and concentrations of inhibitor.	Zinc	30-32	insulin	Homo sapiens	33-40
83864-6	1978	The immunological activity of Zn-insulin and Zn2+-free insulin was compared in both the radioimmune and immune haemolysis-inhibition assays by using an identical population of antibodies and concentrations of inhibitor.	Zinc	45-49	insulin	Homo sapiens	55-62
83864-7	1978	Relative to Zn-insulin, Zn2+-free insulin had a markedly attenuated immunological activity in the immune haemolysis-inhibition assay, whereas in the radioimmune assay slightly greater immunological activity was observed with the Zn2+-free insulin.	Zinc	24-28	insulin	Homo sapiens	34-41
83864-7	1978	Relative to Zn-insulin, Zn2+-free insulin had a markedly attenuated immunological activity in the immune haemolysis-inhibition assay, whereas in the radioimmune assay slightly greater immunological activity was observed with the Zn2+-free insulin.	Zinc	24-28	insulin	Homo sapiens	34-41
83864-7	1978	Relative to Zn-insulin, Zn2+-free insulin had a markedly attenuated immunological activity in the immune haemolysis-inhibition assay, whereas in the radioimmune assay slightly greater immunological activity was observed with the Zn2+-free insulin.	Zinc	229-233	insulin	Homo sapiens	34-41
83864-7	1978	Relative to Zn-insulin, Zn2+-free insulin had a markedly attenuated immunological activity in the immune haemolysis-inhibition assay, whereas in the radioimmune assay slightly greater immunological activity was observed with the Zn2+-free insulin.	Zinc	229-233	insulin	Homo sapiens	34-41
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Zinc	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
117692-3	1978	EDTA was able to counteract the inhibitory effect of Cu(II) or Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II) on kynurenine aminotransferase and partially counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on kynurenine hydrolase.	Zinc	273-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	159-165
4309672-2	1969	The differential effects of adding Zn(2+) and Mg(2+) on the orthophosphatase and inorganic pyrophosphatase activities of human intestinal alkaline phosphatase were studied.	Zinc	35-37	alkaline phosphatase, intestinal	Homo sapiens	127-158
967273-0	1976	[Changes in Zn-insulin conformation].	Zinc	12-14	insulin	Homo sapiens	15-22
1175685-3	1975	Catalase also prevented aggregation and generation of pharmacologically active substances; its activity was reversed by aminothiol agents and by Cu2+ and Zn2+, shown previously to potentiate the platelet effects of arachidonic acid.	Zinc	154-158	catalase	Homo sapiens	0-8
999335-5	1976	In view of concomitant random distribution of metal concentrations in deepest horizons, these relationships and low Zn/Cd ratios in surface horizons nearest to the smelter indicated surface deposition of airborne smelter emissions was responsible for metal contamination of Trail area surface soils.	Zinc	116-118	TNF superfamily member 10	Homo sapiens	274-279
240709-2	1975	At pH 4.6 the addition of Co(II), Cd(II) or Mn(II) to the apoenzyme results in a destabilization of the native protein conformation, but in the range of pH 5.5--8.8 these metal ions, and Zn(II), slightly increase the conformational stability of the protein, in so far as they reduce the probability phi of solvent exposure of the peptide groups.	Zinc	187-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
4309672-4	1969	In the presence of excess of Zn(2+), inorganic pyrophosphatase activity is inhibited.	Zinc	29-31	inorganic pyrophosphatase 1	Homo sapiens	37-62
5698032-0	1968	Role of Zn(II) in the mitochondrial swelling action of insulin.	Zinc	8-14	insulin	Homo sapiens	55-62
4287990-0	1966	Report of a new long-acting (Zn) synthetic ACTH (CIBA 36716 Ba-24 corticotrophin) on adrenal secretion in human subjects.	Zinc	29-31	proopiomelanocortin	Homo sapiens	43-47
32840726-9	2021	Bax/Bcl2 ratio was decreased in the presence of high Zn.	Zinc	53-55	B cell leukemia/lymphoma 2	Mus musculus	4-8
14192915-0	1964	ZN2+ BINDING TO POLY-L-GLUTAMIC ACID AND HUMAN SERUM ALBUMIN.	Zinc	0-4	albumin	Homo sapiens	47-60
33836438-2	2021	Strain SDP-1 can efficiently remove phenol at wide ranges of pH (3.0-9.0), temperature (20-40  C), and NaCl (0-5%, w/v), as well as the tolerance of Mn2+, Zn2+ and Cr3+ in aquatic phase.	Zinc	155-159	mitogen-activated protein kinase tyrosine protein phosphatase SDP1	Saccharomyces cerevisiae S288C	7-12
33872833-6	2021	Zn accumulation of mtm1Delta cells was dramatically decreased compared to wild type cells under excessive zinc condition due to MTM1 deletion reduced zinc uptake.	Zinc	0-2	Mtm1p	Saccharomyces cerevisiae S288C	128-132
33872833-8	2021	The mRNA levels of ZRT1 and ZAP1 decreased in mtm1Delta cells contributing to less Zn uptake.	Zinc	83-85	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	19-23
33865971-4	2021	We hypothesized that substituting the zinc-coordinating urea group for a thiourea group, thus incorporating a sulfur atom, could facilitate stronger binding to zinc(II) within the active site, and thus improve affinity for GCP(II)/PSMA.	Zinc	160-168	folate hydrolase 1	Homo sapiens	223-230
33865971-4	2021	We hypothesized that substituting the zinc-coordinating urea group for a thiourea group, thus incorporating a sulfur atom, could facilitate stronger binding to zinc(II) within the active site, and thus improve affinity for GCP(II)/PSMA.	Zinc	160-168	folate hydrolase 1	Homo sapiens	231-235
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	mitogen-activated protein kinase 14	Homo sapiens	74-77
33307859-4	2021	Zn2+ is known for its binding to insulin hexamer.	Zinc	0-4	insulin	Homo sapiens	33-40
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	nuclear factor kappa B subunit 1	Homo sapiens	186-208
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	nuclear factor kappa B subunit 1	Homo sapiens	210-219
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	interleukin 6	Homo sapiens	335-348
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	interleukin 6	Homo sapiens	350-354
34049221-7	2021	The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation.	Zinc	70-72	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	151-156
34028036-8	2021	A candidate gene association analysis further verified that GRMZM2G142870 and GRMZM2G045531 affect Zn and Mn accumulations, respectively.	Zinc	99-101	ABC transporter C family member 14	Zea mays	60-73
34036507-9	2021	Our results showed a negative association between the alterations in E-cadherin and total elemental components in correlation analysis, especially S, Cl, K, Ti, Mn, Fe, Cu, Zn, and Pb.	Zinc	173-175	cadherin 1	Homo sapiens	69-79
33909969-4	2021	The plaques contain also metal ions of e.g. Cu, Fe, and Zn, and such ions are known to interact with Abeta peptides and modulate their aggregation and toxicity.	Zinc	56-58	amyloid beta precursor protein	Homo sapiens	101-106
33974681-10	2021	Furthermore, an interaction was observed between Zn and serum albumin levels (interaction p = 0.026).	Zinc	49-51	albumin	Homo sapiens	62-69
33939443-3	2021	Red blood cell (RBC)-derived ATP is a recognized stimulus of blood flow, and multiple studies suggest that C-peptide, a hormone secreted in equimolar amounts with insulin from the pancreatic beta-cells, can stimulate that release when delivered by albumin and in combination with Zn2+.	Zinc	280-284	insulin	Homo sapiens	107-116
33939443-8	2021	The RBC-derived ATP increased in the presence of a leptin/C-peptide/Zn2+ addition, in a concentration-dependent manner.	Zinc	68-72	insulin	Homo sapiens	58-67
33882616-3	2021	Herein, it is reported that fast electrokinetic Zn-ion transport extremely improves the Zn metal reversibility.	Zinc	48-50	Fas activated serine/threonine kinase	Homo sapiens	28-32
33955146-4	2021	In Zn/MnO2 assemblies, this mechanism is associated with high gravimetric capacities and discharge potentials, up to 560 mAh g-1 and 1.65 V respectively, attractive efficiencies (CE > 99.5% and EE > 82%) and excellent cyclability (almost 100% capacity retention over 1 400 cycles at 2 A g-1 ).	Zinc	3-5	NBPF member 10	Homo sapiens	285-290
33896171-1	2021	In this study, the effects of metal ions (Al3+, Fe2+, Cu2+, and Zn2+) on precipitation of a purified gallotannin 1,2,3,4,6-penta-O-galloyl-beta-d-glucopyranose (PGG) by bovine serum albumin (BSA) were quantitatively analyzed.	Zinc	64-68	albumin	Homo sapiens	176-189
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Zinc	16-18	tumor necrosis factor	Homo sapiens	99-108
33641237-5	2021	Supplementation with Mn and/or Zn also led to an age-dependent increase in metal content, a decline in overall mRNA expression, and metal co-supplementation induced expression of target genes involved in Mn and Zn homeostasis, in particular metallothionein 1 (mtl-1).	Zinc	31-33	Metallothionein-1	Caenorhabditis elegans	241-258
33959626-6	2021	In a mouse model of atherosclerosis employing Ldlr -/- mice, intravenous administration of scFv-anti-LDL(-)-MCMN-Zn nanoformulation inhibited atherosclerosis progression without affecting vascular permeability or inducing leukocytes-endothelium interactions.	Zinc	113-115	immunglobulin heavy chain variable region	Homo sapiens	91-95
33959626-7	2021	Together, these findings suggest that a scFv-anti-LDL(-)-MCMN-Zn nanoformulation holds promise to be used in future preventive and therapeutic strategies for atherosclerosis.	Zinc	62-64	immunglobulin heavy chain variable region	Homo sapiens	40-44
33923808-1	2021	Superoxide dismutase 1 (SOD1) is a metalloenzyme with high structural stability, but a lack of Cu and Zn ions decreases its stability and enhances the likelihood of misfolding, which is a pathological hallmark of amyotrophic lateral sclerosis (ALS).	Zinc	102-104	superoxide dismutase 1	Homo sapiens	24-28
33577819-0	2021	Zn2+ modulates in vitro phase separation of TDP-432C and mutant TDP-432C-A315T C-terminal fragments of TDP-43 protein implicated in ALS and FTLD-TDP diseases.	Zinc	0-4	TAR DNA binding protein	Mus musculus	44-50
33577819-3	2021	Previously, mice expressing A315T familial ALS TDP-43 mutant showed elevated brain Zn2+ levels.	Zinc	83-87	TAR DNA binding protein	Mus musculus	47-53
33577819-4	2021	Recently, Zn2+ was observed to modulate the in vitro amyloid-like aggregation of the TDP-43"s RRM12 domains.	Zinc	10-14	TAR DNA binding protein	Mus musculus	85-91
33577819-5	2021	As a systematic knowledge of the TDP-43"s interaction with Zn2+ is lacking, we in silico predicted potential Zn2+ binding sites in TDP-43 and estimated their relative solvent accessibilities.	Zinc	59-63	TAR DNA binding protein	Mus musculus	33-39
33577819-5	2021	As a systematic knowledge of the TDP-43"s interaction with Zn2+ is lacking, we in silico predicted potential Zn2+ binding sites in TDP-43 and estimated their relative solvent accessibilities.	Zinc	59-63	TAR DNA binding protein	Mus musculus	131-137
33577819-5	2021	As a systematic knowledge of the TDP-43"s interaction with Zn2+ is lacking, we in silico predicted potential Zn2+ binding sites in TDP-43 and estimated their relative solvent accessibilities.	Zinc	109-113	TAR DNA binding protein	Mus musculus	33-39
33577819-5	2021	As a systematic knowledge of the TDP-43"s interaction with Zn2+ is lacking, we in silico predicted potential Zn2+ binding sites in TDP-43 and estimated their relative solvent accessibilities.	Zinc	109-113	TAR DNA binding protein	Mus musculus	131-137
33577819-6	2021	Zn2+ binding sites were predicted in the TDP-43"s N-terminal domain, in the linker region between RRM1 and RRM2 domain, within RRM2 domain and at the junction of the RRM2 and C-terminal domain (CTD), but none in the 311-360 region of CTD.	Zinc	0-4	TAR DNA binding protein	Mus musculus	41-47
33577819-6	2021	Zn2+ binding sites were predicted in the TDP-43"s N-terminal domain, in the linker region between RRM1 and RRM2 domain, within RRM2 domain and at the junction of the RRM2 and C-terminal domain (CTD), but none in the 311-360 region of CTD.	Zinc	0-4	ribonucleotide reductase M1	Mus musculus	98-102
33577819-9	2021	The observed Zn2+-promoted TDP-43 CTF"s solid-like phase separation can be relevant to the Zn2+ dyshomeostasis in ALS and FTLD-TDP.	Zinc	13-17	TAR DNA binding protein	Mus musculus	27-33
33577819-9	2021	The observed Zn2+-promoted TDP-43 CTF"s solid-like phase separation can be relevant to the Zn2+ dyshomeostasis in ALS and FTLD-TDP.	Zinc	91-95	TAR DNA binding protein	Mus musculus	27-33
33920813-8	2021	Serum Ca, Fe, Se, Zn correlated positively with SpO2, being inversely associated with fever, lung damage, and C-reactive protein concentrations.	Zinc	18-20	C-reactive protein	Homo sapiens	110-128
33788573-3	2021	Although the Zn dopant could reduce the optical band gap and exciton binding energy and enhance the optical absorption and defect tolerance for CsPbBr3, the maximum reduction of the toxic Pb component was just about 12.5% in the experiment because the Zn dopant enlarges the formation energy of CsPb1-xZnxBr3.	Zinc	13-15	mitogen-activated protein kinase 14	Homo sapiens	295-300
33641237-5	2021	Supplementation with Mn and/or Zn also led to an age-dependent increase in metal content, a decline in overall mRNA expression, and metal co-supplementation induced expression of target genes involved in Mn and Zn homeostasis, in particular metallothionein 1 (mtl-1).	Zinc	211-213	Metallothionein-1	Caenorhabditis elegans	241-258
33641237-5	2021	Supplementation with Mn and/or Zn also led to an age-dependent increase in metal content, a decline in overall mRNA expression, and metal co-supplementation induced expression of target genes involved in Mn and Zn homeostasis, in particular metallothionein 1 (mtl-1).	Zinc	31-33	Metallothionein-1	Caenorhabditis elegans	260-265
32705958-6	2021	Obtained results from adsorption experiments of Pb(II) ions on the biochar surface indicate high adsorption capacity, and the possibility of its preconcentration and selective removal in the presence of zinc(II) and cadmium(II) ions.	Zinc	203-211	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
33733413-6	2021	The BAF values follow the order Cd < Cu < Zn < Pb.	Zinc	42-44	BAF nuclear assembly factor 1	Homo sapiens	4-7
33859989-8	2021	Furthermore, the serum and urine Zn concentrations negatively correlated with the serum IL-6 and IL-8 concentrations.	Zinc	33-35	interleukin 6	Homo sapiens	88-92
33859989-8	2021	Furthermore, the serum and urine Zn concentrations negatively correlated with the serum IL-6 and IL-8 concentrations.	Zinc	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33851048-0	2021	DFT and molecular dynamics studies of astaxanthin-metal ions (Cu2+ and Zn2+) complex to prevent glycated human serum albumin from possible unfolding.	Zinc	71-75	albumin	Homo sapiens	111-124
33758258-2	2021	Previous studies have shown that select metal ions, most specifically copper (Cu) and zinc (Zn) ions, have a synergistic effect on the aggregation of Abeta-peptides.	Zinc	92-94	amyloid beta precursor protein	Homo sapiens	150-155
33712543-0	2021	Zn2+ influx activates ERK and Akt signaling pathways.	Zinc	0-4	mitogen-activated protein kinase 1	Homo sapiens	22-25
33712543-0	2021	Zn2+ influx activates ERK and Akt signaling pathways.	Zinc	0-4	AKT serine/threonine kinase 1	Homo sapiens	30-33
33712543-5	2021	By simultaneously monitoring Zn2+ dynamics and kinase activity in individual cells, we quantify changes in labile Zn2+ and directly correlate changes in Zn2+ with ERK and Akt activity.	Zinc	29-33	mitogen-activated protein kinase 1	Homo sapiens	163-166
33712543-5	2021	By simultaneously monitoring Zn2+ dynamics and kinase activity in individual cells, we quantify changes in labile Zn2+ and directly correlate changes in Zn2+ with ERK and Akt activity.	Zinc	29-33	AKT serine/threonine kinase 1	Homo sapiens	171-174
33712543-5	2021	By simultaneously monitoring Zn2+ dynamics and kinase activity in individual cells, we quantify changes in labile Zn2+ and directly correlate changes in Zn2+ with ERK and Akt activity.	Zinc	114-118	mitogen-activated protein kinase 1	Homo sapiens	163-166
33712543-5	2021	By simultaneously monitoring Zn2+ dynamics and kinase activity in individual cells, we quantify changes in labile Zn2+ and directly correlate changes in Zn2+ with ERK and Akt activity.	Zinc	114-118	mitogen-activated protein kinase 1	Homo sapiens	163-166
33645961-4	2021	This bio-MOF is constructed by 9-fluorenylmethyloxycarbonyl-modified histidine (Fmoc-His) as a bridging linker that coordinates with Zn2+ ions, denoted as ZFH.	Zinc	133-137	chromodomain helicase DNA binding protein 3	Homo sapiens	155-158
33655432-1	2022	We aimed to investigate the association between zinc (Zn) supplementation and serum levels of copeptin, high-sensitive C-reactive protein (hs-CRP), glycemic control, anthropometric parameters and renal function in Zn -deficient diabetic hemodialysis patients (DHPs).	Zinc	54-56	arginine vasopressin	Homo sapiens	94-102
33307093-2	2021	This study reports that ZIP13 (SLC39A13), a zinc transporter, plays a role in myocardial I/R injury by modulating the Ca2+ signaling pathway rather than by regulating Zn2+ transport.	Zinc	167-171	solute carrier family 39 (metal ion transporter), member 13	Mus musculus	24-29
33465674-2	2021	We find that Zn2+ activation of the Gq-coupled receptor ZnR/GPR39 controls these processes by regulating K+/Cl- co-transporter KCC3, which modulates cell volume.	Zinc	13-17	solute carrier family 12 member 6	Homo sapiens	127-131
33465674-5	2021	Immunofluorescence analysis indicates that Zn2+ activation of ZnR/GPR39 and KCC3 are required to enhance formation of F-actin stress fibers and cellular protrusions.	Zinc	43-47	solute carrier family 12 member 6	Homo sapiens	76-80
32581187-2	2021	Calmodulin activity is reportedly modulated also by other nutritional divalent cations; thus, we attempted to determine whether Zn++ is involved in the regulation of ABCA1 stability through the modulation of calmodulin activity.	Zinc	128-132	calmodulin 1	Homo sapiens	0-10
32581187-6	2021	Calmodulin binding to ABCA1 was increased by Zn++ and Ca++.	Zinc	45-49	calmodulin 1	Homo sapiens	0-10
32581187-7	2021	Zn++ suppressed calpain-mediated hydrolysis of the peptide of ABCA1 cytosolic loop, including the PEST sequence and the calmodulin-binding site, in a calmodulin-dependent fashion, in the presence of the minimum amount of Ca++ to activate calpain, but not calmodulin.	Zinc	0-4	calmodulin 1	Homo sapiens	120-130
32581187-7	2021	Zn++ suppressed calpain-mediated hydrolysis of the peptide of ABCA1 cytosolic loop, including the PEST sequence and the calmodulin-binding site, in a calmodulin-dependent fashion, in the presence of the minimum amount of Ca++ to activate calpain, but not calmodulin.	Zinc	0-4	calmodulin 1	Homo sapiens	150-160
32581187-7	2021	Zn++ suppressed calpain-mediated hydrolysis of the peptide of ABCA1 cytosolic loop, including the PEST sequence and the calmodulin-binding site, in a calmodulin-dependent fashion, in the presence of the minimum amount of Ca++ to activate calpain, but not calmodulin.	Zinc	0-4	calmodulin 1	Homo sapiens	150-160
32581187-9	2021	CONCLUSION: Nutritional divalent cation Zn++ is involved in the regulation of ABCA1 activity and biogenesis of HDL through the modulation of calmodulin activity.	Zinc	40-44	calmodulin 1	Homo sapiens	141-151
33410087-1	2021	Monoiodo- and dibromsubstituted dipyrromethenes HL1 - HL3 were described as a highly sensitive and selective <<Off-On>> fluorescent chemosensor for Zn2+ based on the chelation-enhanced fluorescence (CHEF) effect.	Zinc	148-152	asialoglycoprotein receptor 1	Homo sapiens	48-51
33410087-2	2021	Soordination reactions of HL1 - HL3 with Zn2+ cations are accompanied by a significant (124 to 215-fold) increase in fluorescence intensity against the background of other metal ions in the binary propanol-1/cyclohexane mixture (1:30).	Zinc	41-45	asialoglycoprotein receptor 1	Homo sapiens	26-29
33410087-3	2021	The fluorometric detection limit of Zn2+ ions using HL1 - HL3 sensors is from 3.0 10-8 to 3.3 10-9 mol/L.	Zinc	36-40	asialoglycoprotein receptor 1	Homo sapiens	52-55
33410087-5	2021	Complexation reactions are accompanied by a visual change in the color of the solution from yellow-orange to pink-raspberry so that the HL1 - HL3 ligands can also be used as a <<naked-eye>> indicators of the presence of Zn2+ ions.	Zinc	220-224	asialoglycoprotein receptor 1	Homo sapiens	136-139
33516376-3	2021	A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC).	Zinc	248-251	interleukin 6	Homo sapiens	125-138
33516376-3	2021	A novel quartz crystal microbalance (QCM) immunoassay method was presented for high sensitivity and selectivity detection of interleukin-6 (IL-6) based on gold nanoparticles functionalized sulfur-doped graphene quantum dot (AuNPs/S-GQD) and hollow ZnS-CdS nanocage (h-ZnS-CdS NC).	Zinc	248-251	interleukin 6	Homo sapiens	140-144
33307093-2	2021	This study reports that ZIP13 (SLC39A13), a zinc transporter, plays a role in myocardial I/R injury by modulating the Ca2+ signaling pathway rather than by regulating Zn2+ transport.	Zinc	167-171	solute carrier family 39 (metal ion transporter), member 13	Mus musculus	31-39
33400970-0	2021	Age-related vulnerability to nigral dopaminergic degeneration in rats via Zn2+-permeable GluR2-lacking AMPA receptor activation.	Zinc	74-78	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	89-94
33400970-5	2021	1-Naphthyl acetyl spermine (NASPM), a selective blocker of Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors blocked increase in intracellular Zn2+ in the SNpc of aged rats followed by rescuing nigral dopaminergic degeneration.	Zinc	69-73	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	84-89
33400970-5	2021	1-Naphthyl acetyl spermine (NASPM), a selective blocker of Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors blocked increase in intracellular Zn2+ in the SNpc of aged rats followed by rescuing nigral dopaminergic degeneration.	Zinc	147-151	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	84-89
33400970-6	2021	The present study indicates that intracellular Zn2+ dysregulation is accelerated by Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptor activation in the SNpc of aged rats, resulting in age-related vulnerability to Parkinson"s syndrome.	Zinc	47-51	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	109-114
33400970-6	2021	The present study indicates that intracellular Zn2+ dysregulation is accelerated by Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptor activation in the SNpc of aged rats, resulting in age-related vulnerability to Parkinson"s syndrome.	Zinc	94-98	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	109-114
32363521-8	2021	The blood glucose level was (p < 0.01) lower in group G3 compared to group G1 suggesting the insulin-like activity of Zn.	Zinc	118-120	insulin	Homo sapiens	93-100
33850744-7	2021	Antioxidative insufficiency of SOD with a low Zn level might be responsible for oxidative stress, which may lead to DNA damage in globozoospermic spermatozoa.	Zinc	46-48	superoxide dismutase 1	Homo sapiens	31-34
33673282-7	2021	Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone.	Zinc	90-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
33673282-7	2021	Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone.	Zinc	135-139	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
33229094-6	2021	Adsorption of p-ASA/ROX on the metal (hydro)oxide and clay minerals was affected by solution pH, co-existing metal ions (Ca2+, Mg2+, Al3+, Cu2+, Fe3+, and Zn2+), oxyanions (H2PO4-, HCO3-, and SO42-), and humic acid.	Zinc	155-159	MAX network transcriptional repressor	Homo sapiens	14-23
33514951-3	2021	Tl2(OCtBu2Ph)2 serves as a convenient precursor to the formation of old and new [M(OCtBu2Ph)n] complexes (M = Cr, Fe, Cu, Zn), including a rare example of T-shaped Zn(OCtBu2Ph)2(THF) complex, which could not be previously synthesized using more conventional LiOR/HOR precursors.	Zinc	122-124	TNF superfamily member 10	Homo sapiens	0-14
33528512-4	2021	We found that autophagy-defective Arabidopsis thaliana (atg2 and atg5) exhibited marked excess Zn-induced chlorosis and growth defects relative to wild-type.	Zinc	95-97	autophagy 2	Arabidopsis thaliana	56-60
33528512-4	2021	We found that autophagy-defective Arabidopsis thaliana (atg2 and atg5) exhibited marked excess Zn-induced chlorosis and growth defects relative to wild-type.	Zinc	95-97	autophagy protein Apg5 family	Arabidopsis thaliana	65-69
33528512-6	2021	Interestingly, the excess Zn symptoms of atg5 were alleviated by supplementation of high levels of iron (Fe) to the media.	Zinc	26-28	autophagy protein Apg5 family	Arabidopsis thaliana	41-45
33528512-7	2021	Under excess Zn, in atg5, Fe starvation was especially severe in juvenile true leaves.	Zinc	13-15	autophagy protein Apg5 family	Arabidopsis thaliana	20-24
33579477-10	2021	The variations in protein adsorption might lead to the downregulation of the NF-kappaB pathway, thus explain the observed biological effects of Zn incorporation into biomaterials.	Zinc	144-146	nuclear factor kappa B subunit 1	Homo sapiens	77-86
33333205-4	2021	After adjusting for multiple possible confounders, higher serum Zn concentrations were associated with lower beta cell insulin secretion (HOMA2-B; p =0.01) and lower insulin resistance (HOMA-IR; p=0.04) in the prediabetic subjects.	Zinc	64-66	insulin	Homo sapiens	119-126
33333205-4	2021	After adjusting for multiple possible confounders, higher serum Zn concentrations were associated with lower beta cell insulin secretion (HOMA2-B; p =0.01) and lower insulin resistance (HOMA-IR; p=0.04) in the prediabetic subjects.	Zinc	64-66	insulin	Homo sapiens	166-173
33333394-9	2021	Serum interleukin 6 (ES = -1.02 pg/mL, 95% CI = [-2.06, 0.02], P = 0.05, I2 = 92.3%) was marginally reduced following Zn supplementation.	Zinc	118-120	interleukin 6	Homo sapiens	6-19
33333394-11	2021	CONCLUSION: This meta-analysis suggests that Zn supplements reduce serum concentrations of markers of inflammation and oxidation: CRP, TNF-alpha and MDA.	Zinc	45-47	C-reactive protein	Homo sapiens	130-133
33333394-11	2021	CONCLUSION: This meta-analysis suggests that Zn supplements reduce serum concentrations of markers of inflammation and oxidation: CRP, TNF-alpha and MDA.	Zinc	45-47	tumor necrosis factor	Homo sapiens	135-144
32013770-2	2021	Zinc metal carboxylates (AAZ1 - AAZ6) were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Zinc	0-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
33360236-8	2021	The expression of ZmPIP1;1, ZmPIP1;2, and ZmPIP2;2 was significantly higher with moderate Zn treatment than that of low-level Zn treatment.	Zinc	90-92	aquaporin PIP2-2	Zea mays	42-50
33047410-6	2021	In addition, plants that absorb more NO3 - than NH4 + increase the soil pH and decrease the availability of iron (Fe), manganese (Mn), and zinc (Zn).	Zinc	145-147	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
33477854-8	2021	In addition, ATP1A1 and ATP8 could be used as the key genes to detect K and Zn, respectively.	Zinc	76-78	ATP synthase F0 subunit 8	Anas platyrhynchos	24-28
33553758-3	2021	SOD1 is an antioxidant enzyme characterized by the presence of two metal ions, Cu and Zn, on its active site.	Zinc	86-88	superoxide dismutase 1	Homo sapiens	0-4
33553758-4	2021	On the SOD1, Cu exerts a catalytic role, and Zn serves a structural function.	Zinc	45-47	superoxide dismutase 1	Homo sapiens	7-11
33553758-5	2021	In this study, we generated a modified SOD1 characterized by an altered capacity to complex Zn.	Zinc	92-94	superoxide dismutase 1	Homo sapiens	39-43
33553758-6	2021	The study investigates the metal-binding dynamics of the enzyme, estimating the stability of a SOD1 protein lacking the appropriate Zn site complexation.	Zinc	132-134	superoxide dismutase 1	Homo sapiens	95-99
33553758-7	2021	Our mutant SOD1 possesses a double amino acid mutation (T135S and K136E) that interferes with the correct Zn site complexation.	Zinc	106-108	superoxide dismutase 1	Homo sapiens	11-15
33400522-0	2021	Unexpected Trends in Copper Removal from Abeta Peptide: When Less Ligand Is Better and Zn Helps.	Zinc	87-89	amyloid beta precursor protein	Homo sapiens	41-46
33494250-11	2021	In this paper, we show that, as a function of the concentration and time of exposure, Zn causes decreases in the radicle and plumule lengths and promotes the accumulation of reactive oxygen species (ROS) and flavonoids as well as changes in the activity of the cell wall Class III peroxidase (POD), which was quantified with guaiacol or catechin in the presence of H2O2.	Zinc	86-88	peroxidase 1	Zea mays	281-291
33494250-11	2021	In this paper, we show that, as a function of the concentration and time of exposure, Zn causes decreases in the radicle and plumule lengths and promotes the accumulation of reactive oxygen species (ROS) and flavonoids as well as changes in the activity of the cell wall Class III peroxidase (POD), which was quantified with guaiacol or catechin in the presence of H2O2.	Zinc	86-88	peroxidase 1	Zea mays	293-296
33468279-13	2021	Zn could decrease IL-6 levels (SMD= -0.76 pg/ml; 95% CI: -1.28, -0.24; P= 0.004).	Zinc	0-2	interleukin 6	Homo sapiens	18-22
33468279-15	2021	However, Zn could increase IL-2 significantly after deletion of one arm in sensitivity analysis (SMD= 2.96 pg/ml; 95% CI: 2.03, 3.88; P< 0.05).	Zinc	9-11	interleukin 2	Homo sapiens	27-31
33468279-16	2021	Conclusively, Zn supplementation can decrease the IL-6 level.	Zinc	14-16	interleukin 6	Homo sapiens	50-54
33468279-17	2021	Zn increased IL-2 level after sensitivity analysis.	Zinc	0-2	interleukin 2	Homo sapiens	13-17
33477475-6	2021	The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb-Zn mine.	Zinc	116-118	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	4-6
33520975-5	2020	In this work, glutathione stabilized alloy Au/Ag NCs were synthesized via a simple method and used for the fluorescence detection of PPi and PPase based on a Zn2+-regulated AIE strategy.	Zinc	158-162	inorganic pyrophosphatase 1	Homo sapiens	141-146
32905031-7	2021	Further, the high-resolution Mn 2p, Zn 2p, Fe 2p, and O 1s spectra of Mn1-xZnxFe2O4 does not result in the appearance of new peaks with Zn content, indicating that the Zn substitution does not change the ionic state of Mn, Zn, Fe, and O present in nanocrystalline Mn1-xZnxFe2O4.	Zinc	75-77	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	70-73
32905031-7	2021	Further, the high-resolution Mn 2p, Zn 2p, Fe 2p, and O 1s spectra of Mn1-xZnxFe2O4 does not result in the appearance of new peaks with Zn content, indicating that the Zn substitution does not change the ionic state of Mn, Zn, Fe, and O present in nanocrystalline Mn1-xZnxFe2O4.	Zinc	75-77	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	70-73
32905031-7	2021	Further, the high-resolution Mn 2p, Zn 2p, Fe 2p, and O 1s spectra of Mn1-xZnxFe2O4 does not result in the appearance of new peaks with Zn content, indicating that the Zn substitution does not change the ionic state of Mn, Zn, Fe, and O present in nanocrystalline Mn1-xZnxFe2O4.	Zinc	75-77	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	70-73
33520975-6	2020	The controlled release of Zn2+ by PPi and PPase could regulate the AIE of Au/Ag NCs and be employed to response PPi concentration and PPase activity.	Zinc	26-30	inorganic pyrophosphatase 1	Homo sapiens	42-47
33520975-6	2020	The controlled release of Zn2+ by PPi and PPase could regulate the AIE of Au/Ag NCs and be employed to response PPi concentration and PPase activity.	Zinc	26-30	inorganic pyrophosphatase 1	Homo sapiens	134-139
33405078-7	2021	Our analysis demonstrated a significantly decreased level of Fe, Zn, and Se among human CL and canine leishmaniasis, and Zn and Fe in patients with VL.	Zinc	121-123	modulator of VRAC current 1	Homo sapiens	148-150
31994452-3	2021	Therefore, this work was done to evaluate toxicity of Zinc oxide nanoparticles (ZnO NPs) on the structure of human serum albumin (HSA) through in vitro and in silico studies.	Zinc	80-83	albumin	Homo sapiens	115-128
32947215-6	2021	However, cells pretreated with Zn2+ before Hg2+-exposure showed a significant improvement in cell viability, cell membrane, DNA damage, glutathione level, ROS amount and apoptotic cells, with a significant upregulation in mTOR, akt, ERK1, Nrf2, HO1, Bcl-2 and Bcl-xL, and downregulation in p53, Bax, cytochrome c and cleaved caspase 3, indicating inhibition of apoptosis.	Zinc	31-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	239-243
32947215-7	2021	The findings suggested that Zn2+-pretreatment not only improves glutathione content but also induces activation of Nrf2-HO1 pathway, which would tend to suppress Hg-cytotoxicity.	Zinc	28-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
33278510-9	2021	s-1) adduction of etoposide quinone with redox sensitive cysteine residues within the RING and PHD Zn2+-fingers of CREBBP catalytic core leading to subsequent release of Zn2+.	Zinc	99-103	CREB binding protein	Homo sapiens	115-121
33278510-9	2021	s-1) adduction of etoposide quinone with redox sensitive cysteine residues within the RING and PHD Zn2+-fingers of CREBBP catalytic core leading to subsequent release of Zn2+.	Zinc	170-174	CREB binding protein	Homo sapiens	115-121
32862078-6	2021	For treatment with the Zn-based complex, changes associated with cytochrome c were not detected, neither a rapid leakage of nucleus content upon 24 h treatment.	Zinc	23-25	cytochrome c, somatic	Homo sapiens	65-77
33306695-8	2020	In MCD rat serum, Zn was inversely correlated with IL-1beta, IL-6, TNF-alpha, Urea and Uric Acid; Ca2+ was inversely correlated with IL-1beta, IL-6 and Urea; Cl and Mg were directly correlated with Uric Acid and Urea, respectively.	Zinc	18-20	interleukin 1 alpha	Rattus norvegicus	51-59
33514210-5	2021	Above T > 600 K, Sn2+ is observed and is ascribed to Sn on regular Zn sites, while Sn2+ detected at T < 600 K is due to Sn in local amorphous regions.	Zinc	67-69	solute carrier family 38 member 5	Homo sapiens	17-20
33953872-9	2021	Also, a correlation between seminal Zn concentration with fresh semen gross and progressive motility, average path velocity, and beat cross frequency, Cu with SOD and Fe and semen concentration was observed.	Zinc	36-38	superoxide dismutase 1	Homo sapiens	159-162
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	129-133	tumor protein p53	Homo sapiens	7-10
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	129-133	tumor protein p53	Homo sapiens	89-92
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	129-133	tumor protein p53	Homo sapiens	89-92
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	137-141	tumor protein p53	Homo sapiens	7-10
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	137-141	tumor protein p53	Homo sapiens	89-92
33238842-7	2021	Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) that restore WT p53 structure and function by restoring Zn2+ to Zn2+ deficient mutant p53.	Zinc	137-141	tumor protein p53	Homo sapiens	89-92
33155397-8	2021	Zn reversed the hyperglycemia caused by CAF diet and reduced IL-6 levels.	Zinc	0-2	interleukin 6	Rattus norvegicus	61-65
33458549-6	2021	Notably, in the adsorption experiments, the Fe3O4@S-S/PMAA nanoparticles were demonstrated to have a maximum adsorption capacity of 48.7 mg g-1 on Pb(II) ions with a selective adsorption order of Pb2+ > Co2+ > Cd2+ > Ni2+ > Cu2+ > Zn2+ > K+ > Na+ > Mg2+ > Ca2+ in the selective experiments.	Zinc	231-235	submaxillary gland androgen regulated protein 3B	Homo sapiens	147-153
33306695-8	2020	In MCD rat serum, Zn was inversely correlated with IL-1beta, IL-6, TNF-alpha, Urea and Uric Acid; Ca2+ was inversely correlated with IL-1beta, IL-6 and Urea; Cl and Mg were directly correlated with Uric Acid and Urea, respectively.	Zinc	18-20	interleukin 6	Rattus norvegicus	61-65
33306695-8	2020	In MCD rat serum, Zn was inversely correlated with IL-1beta, IL-6, TNF-alpha, Urea and Uric Acid; Ca2+ was inversely correlated with IL-1beta, IL-6 and Urea; Cl and Mg were directly correlated with Uric Acid and Urea, respectively.	Zinc	18-20	tumor necrosis factor	Rattus norvegicus	67-76
32856362-3	2020	Once endocytosed by tumor cells, the catalase DNAzymes-loaded zeolitic imidazole framework-82 (ZIF-82@CAT Dz) shell can be degraded into Zn2+ as cofactors for CAT Dz-mediated CAT silencing and electrophilic ligands for glutathione (GSH) depletion under hypoxia, both of which lead to intracellular RDH and H2O2 accumulation.	Zinc	137-141	catalase	Homo sapiens	102-105
32856362-3	2020	Once endocytosed by tumor cells, the catalase DNAzymes-loaded zeolitic imidazole framework-82 (ZIF-82@CAT Dz) shell can be degraded into Zn2+ as cofactors for CAT Dz-mediated CAT silencing and electrophilic ligands for glutathione (GSH) depletion under hypoxia, both of which lead to intracellular RDH and H2O2 accumulation.	Zinc	137-141	catalase	Homo sapiens	159-162
32856362-3	2020	Once endocytosed by tumor cells, the catalase DNAzymes-loaded zeolitic imidazole framework-82 (ZIF-82@CAT Dz) shell can be degraded into Zn2+ as cofactors for CAT Dz-mediated CAT silencing and electrophilic ligands for glutathione (GSH) depletion under hypoxia, both of which lead to intracellular RDH and H2O2 accumulation.	Zinc	137-141	catalase	Homo sapiens	159-162
33215912-4	2020	Experimental works indicate the loss of thermostability of the rhodopsin protein, subjected to the combination of-typical for the disease-mutations and increased quantity of Zn2+.	Zinc	174-178	rhodopsin	Homo sapiens	63-72
32818499-5	2020	Mechanically, post-transcriptional regulated protein quantities compromising phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway was demonstrated true causative forces inside the cell for Zn against As poisoning.	Zinc	241-243	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	77-106
33137558-4	2020	EGC and ECG mildly bind to Cu2+ and Zn2+, and diminish the Cu2+- or Zn2+-induced or self-assembled Abeta aggregates; they also modulate the Cu2+/Zn2+-Abeta40 induced neurotoxicity on mouse neuroblastoma Neuro-2a cells by reducing the production of ROS.	Zinc	68-72	amyloid beta precursor protein	Homo sapiens	99-104
33137558-4	2020	EGC and ECG mildly bind to Cu2+ and Zn2+, and diminish the Cu2+- or Zn2+-induced or self-assembled Abeta aggregates; they also modulate the Cu2+/Zn2+-Abeta40 induced neurotoxicity on mouse neuroblastoma Neuro-2a cells by reducing the production of ROS.	Zinc	68-72	amyloid beta precursor protein	Homo sapiens	99-104
32818499-5	2020	Mechanically, post-transcriptional regulated protein quantities compromising phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway was demonstrated true causative forces inside the cell for Zn against As poisoning.	Zinc	241-243	AKT serine/threonine kinase 1	Homo sapiens	132-135
32818499-5	2020	Mechanically, post-transcriptional regulated protein quantities compromising phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway was demonstrated true causative forces inside the cell for Zn against As poisoning.	Zinc	241-243	mechanistic target of rapamycin kinase	Homo sapiens	137-166
32818499-5	2020	Mechanically, post-transcriptional regulated protein quantities compromising phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway was demonstrated true causative forces inside the cell for Zn against As poisoning.	Zinc	241-243	mechanistic target of rapamycin kinase	Homo sapiens	168-172
32712520-4	2020	RESULTS: Considering total element evaluation through ICP-MS, Co, Ni, Mn, and Zn are found at the highest concentrations in the sample, namely 415 +- 36, 202 +- 55, 1389 +- 225 and 2397 +- 197 mug L-1, respectively.	Zinc	78-80	L1 cell adhesion molecule	Homo sapiens	197-200
33047344-11	2020	In this study, CTS and beta-CD were cross-linked to synthesize a biomass membrane for adsorbing Zn2+ to reduce the Zn2+ content in wastewater via adsorption.The results show that the CTS/beta-CDP composite membrane can be applied to small-scale wastewater treatment fields such as food and chemical industry.	Zinc	96-100	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	23-30
33047344-11	2020	In this study, CTS and beta-CD were cross-linked to synthesize a biomass membrane for adsorbing Zn2+ to reduce the Zn2+ content in wastewater via adsorption.The results show that the CTS/beta-CDP composite membrane can be applied to small-scale wastewater treatment fields such as food and chemical industry.	Zinc	115-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	23-30
33294736-6	2021	RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/beta-catenin, PI3K/Akt, and MAPK/Erk signaling pathways.	Zinc	36-38	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
33260324-3	2020	Recently it was shown that TDP-43 is able to bind Zn2+ by its RRM domain.	Zinc	50-54	TAR DNA binding protein	Homo sapiens	27-33
33260324-7	2020	Together with the existing structure of the RRM2 domain of TDP-43 we propose a model of its complex with Zn2+ which illustrates how zinc might regulate DNA/RNA binding.	Zinc	105-109	TAR DNA binding protein	Homo sapiens	59-65
33294736-6	2021	RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/beta-catenin, PI3K/Akt, and MAPK/Erk signaling pathways.	Zinc	36-38	Eph receptor B1	Rattus norvegicus	128-131
33090803-0	2020	H2S Generation from CS2 Hydrolysis at a Dinuclear Zinc(II) Site.	Zinc	50-58	chorionic somatomammotropin hormone 2	Homo sapiens	20-23
33201834-3	2020	Notably, CdSe/ZnS QDs treatment increased the contents of MDA and ROS, and decreased the activities of SOD, CAT and GSH-Px; however, the co-treatment of NAC and QDs relieved the oxidative damage of NRK cells.	Zinc	14-17	catalase	Rattus norvegicus	108-111
33201834-5	2020	CONCLUSIONS: CdSe/ZnS QDs exhibited obvious nephrotoxicity by mediating oxidative damage and inflammatory response in vitro and in vivo via NRF2/Keap1 pathway.	Zinc	18-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
33090803-4	2020	Moreover, [ZnII]-OH sites present in the isolated tetranuclear zinc(II) complex {(LZnII)2(mu-OH)}2(ClO4)2 (4) react with CS2, thereby suggesting that the [ZnII]-OH site serves as the active nucleophile.	Zinc	63-71	chorionic somatomammotropin hormone 2	Homo sapiens	121-124
33409464-13	2020	Additionally, differences in liver MT1A expression may indicate differing post-absorptive metabolism between Zn sources.	Zinc	109-111	metallothionein 1A	Homo sapiens	35-39
33074685-4	2020	Under photolytic conditions, 2 loses CO to give Ru(ZnPhos)(CO)2 that then adds H2 over the Ru-Zn bond to form Ru(ZnPhos)(CO)2(mu-H)2 (3).	Zinc	51-53	familial progressive hyperpigmentation 1	Homo sapiens	126-132
33198336-7	2020	In addition, NAC inhibited the Zn-induced Nrf2 activation and limited the concomitant upregulation of cellular GSH concentrations.	Zinc	31-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
33190050-0	2020	Alkaline phosphatase-responsive Zn2+ double-triggered nucleotide capped gold nanoclusters/ alginate hydrogel with recyclable nanozyme capability.	Zinc	32-36	alkaline phosphatase, placental	Homo sapiens	0-20
32518388-5	2020	Zn2+:Abeta aggregates were toxic to the slices, but Abeta alone was not.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	5-10
32877770-7	2020	BAF in salt marhes and mangroves is as Cd < Pb < Cu < Zn and Cd < Cu < Pb < Zn, respectively.	Zinc	54-56	BAF nuclear assembly factor 1	Homo sapiens	0-3
32877770-7	2020	BAF in salt marhes and mangroves is as Cd < Pb < Cu < Zn and Cd < Cu < Pb < Zn, respectively.	Zinc	76-78	BAF nuclear assembly factor 1	Homo sapiens	0-3
32281435-9	2020	Early stage of insulin resistance (IR) in the group of women with PCOS affected on higher Cu concentration and Cu/Zn value.	Zinc	114-116	insulin	Homo sapiens	15-22
32768728-3	2020	In this study, we have examined structure and dynamics of SOD1 protein upon two ALS associated point mutations at the surface residue Glu100 (E100G and E100K), which is located far from the Cu and Zn sites and dimer interface.	Zinc	197-199	superoxide dismutase 1	Homo sapiens	58-62
33030499-7	2020	The results show that extracellular Zn2+ ions reduced the activation of AP-1 by more than 80% following stimulation of either voltage-gated Cav1.2 channels or TRPM3 channels.	Zinc	36-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
33081348-2	2020	Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Abeta), loaded with metal ions including Cu, Fe, or Zn.	Zinc	178-180	amyloid beta precursor protein	Homo sapiens	112-124
33054172-6	2020	We confirmed that NP-upregulated HIF-1alpha protein expression was attributed to prolyl hydroxylase inhibition by both ROS and Zn2+.	Zinc	127-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
33060722-5	2020	Importantly, when the complex also included Zn2+, a significant increase in cell membrane GLUT1 was measured, thus providing a cellular effect similar to insulin, but on a transporter on which insulin has no effect.	Zinc	44-48	insulin	Homo sapiens	154-161
32781220-6	2020	13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of  OH radicals.	Zinc	171-175	acetylcholinesterase (Cartwright blood group)	Homo sapiens	17-21
33060722-5	2020	Importantly, when the complex also included Zn2+, a significant increase in cell membrane GLUT1 was measured, thus providing a cellular effect similar to insulin, but on a transporter on which insulin has no effect.	Zinc	44-48	insulin	Homo sapiens	193-200
32718595-4	2020	The maximum swelling ratio (1000.0 %) was optimized at pH 10, 180 min and 25  C. The validity of NFe3O4@Zn(GA)/Starch-Hydrogel for adsorptive removal of Fluvastatin statin drug provided maximum equilibrium adsorption capacity 782.05 mg g-1.	Zinc	104-106	nuclear receptor subfamily 2 group F member 2	Homo sapiens	97-101
33024112-2	2020	Using an NMR/X-ray approach, we determined the structure of the complex between retromer subunit VPS29 and a 12 residue, four-cysteine/Zn++ microdomain, which we term a Zn-fingernail, two of which are present in VARP.	Zinc	135-137	VPS29 retromer complex component	Homo sapiens	97-102
33019780-10	2020	A significant increase in the intracellular SOD1 concentration in plasma of AP patients proves the important role of this isoenzyme in the neutralization of oxidative stress induced by impaired Cu and Zn homeostasis.	Zinc	201-203	superoxide dismutase 1	Homo sapiens	44-48
32816651-4	2020	This study aimed to determine the genetic effect of MT1A rs8052394 on lead (Pb), cadmium (Cd), zinc (Zn), and aluminum (Al) levels in factory workers.	Zinc	101-103	metallothionein 1A	Homo sapiens	52-56
32413760-6	2020	Fe, Cu and Zn were associated with biomolecules with high molecular mass compounds, such as immunoglobulins, albumin and lactoferrin whilst iodine was only found as iodide.	Zinc	11-13	albumin	Homo sapiens	109-116
32783848-5	2020	The results showed that Zn application at the rate of 5.7 kg ha-1 significantly increased the activities of urease, invertase, alkaline phosphatase and catalase in the soil, while the rate of 34.1 kg ha-1 significantly decreased the evaluated enzyme activities.	Zinc	24-26	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	61-65
32783848-5	2020	The results showed that Zn application at the rate of 5.7 kg ha-1 significantly increased the activities of urease, invertase, alkaline phosphatase and catalase in the soil, while the rate of 34.1 kg ha-1 significantly decreased the evaluated enzyme activities.	Zinc	24-26	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	200-204
32816651-10	2020	A significant association was found between single-nucleotide polymorphisms (SNPs) of MT1A gene and Cd (p = 0.006) and with Zn levels (p = 0.031) but no association found with Pb and Al levels.	Zinc	124-126	metallothionein 1A	Homo sapiens	86-90
32870649-8	2020	A plausible PHR mechanism has been provided to elucidate a great performance of Ho-modified Zn(O,S) for photocatalytic hydrogenation.	Zinc	92-94	MYC binding protein 2	Homo sapiens	12-15
33455195-3	2020	With lysozyme (Lys) wrapped on the surface of Zn-based ZIF (ZIF-8), Lys/ZIF-8 could strongly bond metal ions to promote nucleation and growth of bone-like hydroxyapatite (HAp), leading to formation of HAp@Lys/ZIF-8 composites.	Zinc	46-48	lysozyme	Homo sapiens	5-13
32417510-5	2020	Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on <250 mum fraction) indicated BAF of As (5-33%), Cd (72-98%), Co (24-42%), Cr (3-11%), Cu (25-90%), Ni (17-60%), Pb (16-88%) and Zn (73-94%).	Zinc	252-254	BAF nuclear assembly factor 1	Homo sapiens	50-53
32799855-9	2020	Furthermore, superoxide dismutase and catalase activities including glutathione content were significantly low in cells induced with Zn.	Zinc	133-135	catalase	Mus musculus	38-46
32870649-7	2020	As Ho doped in the lattices of Zn(O,S), it acts not only to separate photocarriers and to enhance the charge transfer but also to shorten the diffusing time of nitrophenolate ions to catalyst surfaces for further PHR process.	Zinc	31-33	MYC binding protein 2	Homo sapiens	213-216
32638783-7	2020	We propose that hemodilution and the rapid, efficient postprandial transfer of albumin-bound Zn from serum to the liver and pancreas is responsible for the lack of postprandial serum Zn isotopic response.	Zinc	93-95	albumin	Homo sapiens	79-86
32865397-2	2020	MAF-123-Mn/Zn/Cu were synthesized by the solvothermal method on a gram scale.	Zinc	11-13	MAF bZIP transcription factor	Homo sapiens	0-3
32865397-4	2020	Molecule simulations revealed that a shorter ethane-framework interaction distance in MAF-123-Zn than that in MAF-123-Mn is responsible for the increased adsorption energy.	Zinc	94-96	MAF bZIP transcription factor	Homo sapiens	86-89
33042025-11	2020	Although we did not identify a statistical association between serum Zn concentration and PCOS overall, the concentration of Zn in PCOS women with insulin resistance (IR) was lower than that in healthy women (SMD = -0.89, 95% CI: -1.73 to -0.06).	Zinc	125-127	insulin	Homo sapiens	147-154
32915786-7	2020	Knocking down the expression levels of ZnT1 (located mostly at the plasma membrane) and ZIP8 (present in endosomes and lysosomes) increased and decreased the ZnO-NP-induced elevation of [Zn2+]c, respectively.	Zinc	187-191	solute carrier family 30 member 1	Homo sapiens	39-43
32416427-5	2020	Cu and Zn ions were mainly electrochemically adsorbed on the carbon cathode and anode, respectively, resulting in decreases of their concentrations to below 1 mg L-1 in the leachate.	Zinc	7-9	L1 cell adhesion molecule	Homo sapiens	162-165
32542960-11	2020	CONCLUSIONS: Our results suggest a novel role for Zn2+ in the binding and activation of FXII at the platelet surface, an interaction that appears crucial to FXII-dependent thrombin generation but dispensable for hemostasis.	Zinc	50-54	coagulation factor II	Mus musculus	172-180
33455195-3	2020	With lysozyme (Lys) wrapped on the surface of Zn-based ZIF (ZIF-8), Lys/ZIF-8 could strongly bond metal ions to promote nucleation and growth of bone-like hydroxyapatite (HAp), leading to formation of HAp@Lys/ZIF-8 composites.	Zinc	46-48	lysozyme	Homo sapiens	15-18
33455195-3	2020	With lysozyme (Lys) wrapped on the surface of Zn-based ZIF (ZIF-8), Lys/ZIF-8 could strongly bond metal ions to promote nucleation and growth of bone-like hydroxyapatite (HAp), leading to formation of HAp@Lys/ZIF-8 composites.	Zinc	46-48	lysozyme	Homo sapiens	68-71
33455195-3	2020	With lysozyme (Lys) wrapped on the surface of Zn-based ZIF (ZIF-8), Lys/ZIF-8 could strongly bond metal ions to promote nucleation and growth of bone-like hydroxyapatite (HAp), leading to formation of HAp@Lys/ZIF-8 composites.	Zinc	46-48	lysozyme	Homo sapiens	68-71
32305837-3	2020	A significant enhancement in fluorescence emission band centered at 450 nm was observed in the ethanolic solution of HL1 with addition of Zn2+, while remarkably lower fluorescence emission enhancement was obtained in the case of HL2 in which one methyl group was introduced to the azomethine carbon.	Zinc	138-142	asialoglycoprotein receptor 1	Homo sapiens	117-120
32517868-10	2020	This study also demonstrated the opposite functions of the two zinc transporters, ZIP10 and ZnT1 as well as shedding light on the role of Zn2+ in regulation of the human hatching enzyme homologue, ovastacin, which is activated by zinc and cleaves the zona pellucida protein, ZP2, to prevent polyspermy.	Zinc	138-142	astacin like metalloendopeptidase	Homo sapiens	197-206
32305837-4	2020	In addition, HL1 showed good selectivity and high sensitivity towards Zn2+ in the existence of other various interfering metal ions, and the reversibility and regeneration of HL1 were also perfect for extending its applications in environmental and biological systems.	Zinc	70-74	asialoglycoprotein receptor 1	Homo sapiens	13-16
32305837-5	2020	Therefore, HL1 could be identified as a fluorescent probe for sensing Zn2+ environmentally and biologically.	Zinc	70-74	asialoglycoprotein receptor 1	Homo sapiens	11-14
32784718-0	2020	Pro-Oxidant Activity of an ALS-Linked SOD1 Mutant in Zn-Deficient Form.	Zinc	53-55	superoxide dismutase 1	Homo sapiens	38-42
32076947-14	2020	Zn administration led to significant protection of HepG2 cells against DON-induced adverse effects, probably via activation of the Nrf2-Keap1 pathway.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
32610223-6	2020	Exposure to high Zn altered the mRNA expression levels of specific zip transporters, with an increase in zip1 (at 3 dpf) and zip8 (at 5 dpf), and a decrease in zip4 (at 5 dpf).	Zinc	17-19	solute carrier family 39 member 1	Danio rerio	105-109
32610223-6	2020	Exposure to high Zn altered the mRNA expression levels of specific zip transporters, with an increase in zip1 (at 3 dpf) and zip8 (at 5 dpf), and a decrease in zip4 (at 5 dpf).	Zinc	17-19	solute carrier family 39 member 4	Danio rerio	160-164
32076947-14	2020	Zn administration led to significant protection of HepG2 cells against DON-induced adverse effects, probably via activation of the Nrf2-Keap1 pathway.	Zinc	0-2	kelch like ECH associated protein 1	Homo sapiens	136-141
32196765-4	2020	Insulin associates into dimers and further into hexamers with stabilization by Zn2+ and phenolic ligands.	Zinc	79-83	insulin	Homo sapiens	0-7
32504391-9	2020	Co-administration of Zn and Se significantly decreased the potential collapse of mitochondrial membrane, reactive oxygen species levels, and lipid peroxidation levels while significantly increased cognitive performance, superoxide dismutase (SOD), glutathione peroxidase, and catalase activity in the brain mitochondria compared with the STZ group.	Zinc	21-23	catalase	Rattus norvegicus	276-284
32346941-7	2020	ZN also rescued the ZnT3 loss-associated reduction of neurogenesis via elevation of IGF-1 and ERK/CREB activation.	Zinc	0-2	mitogen-activated protein kinase 1	Mus musculus	94-97
32346941-7	2020	ZN also rescued the ZnT3 loss-associated reduction of neurogenesis via elevation of IGF-1 and ERK/CREB activation.	Zinc	0-2	cAMP responsive element binding protein 1	Mus musculus	98-102
32751915-2	2020	Hst 5 binds to multiple cations including dimerization-inducing zinc (Zn2+), although the function of this capability is incompletely understood.	Zinc	70-74	histatin 3	Homo sapiens	0-5
32751915-3	2020	Hst 5 is taken up by C. albicans and acts on intracellular targets under metal-free conditions; however, Zn2+ is abundant in saliva and may functionally affect Hst 5.	Zinc	105-109	histatin 3	Homo sapiens	0-5
32751915-3	2020	Hst 5 is taken up by C. albicans and acts on intracellular targets under metal-free conditions; however, Zn2+ is abundant in saliva and may functionally affect Hst 5.	Zinc	105-109	histatin 3	Homo sapiens	160-165
32751915-5	2020	Through the use of Hst 5 and two derivatives, P113 (AA 4-15 of Hst 5) and Hst 5DeltaMB (AA 1-3 and 15-19 mutated to Glu), we determined that Zn2+ significantly increases killing activity of Hst 5 and P113 for both C. albicans and Candida glabrata.	Zinc	141-145	histatin 3	Homo sapiens	19-24
32751915-5	2020	Through the use of Hst 5 and two derivatives, P113 (AA 4-15 of Hst 5) and Hst 5DeltaMB (AA 1-3 and 15-19 mutated to Glu), we determined that Zn2+ significantly increases killing activity of Hst 5 and P113 for both C. albicans and Candida glabrata.	Zinc	141-145	histatin 3	Homo sapiens	63-68
32751915-5	2020	Through the use of Hst 5 and two derivatives, P113 (AA 4-15 of Hst 5) and Hst 5DeltaMB (AA 1-3 and 15-19 mutated to Glu), we determined that Zn2+ significantly increases killing activity of Hst 5 and P113 for both C. albicans and Candida glabrata.	Zinc	141-145	histatin 3	Homo sapiens	63-68
32751915-8	2020	High-performance liquid chromatography (HPLC) showed that the higher relative Zn2+ affinity of Hst 5 likely promotes dimerization.	Zinc	78-82	histatin 3	Homo sapiens	95-100
32751915-9	2020	Together, these results suggest peptide assembly into fungicidal pore structures in the presence of Zn2+, representing a novel mechanism of action that has exciting potential to expand the list of Hst 5-susceptible pathogens.	Zinc	100-104	histatin 3	Homo sapiens	197-202
32723473-1	2020	ZnT8 is a Zn2+/H+ antiporter that belongs to SLC30 family and plays an essential role in regulating Zn2+ accumulation in the insulin secretory granules of pancreatic beta cells.	Zinc	10-14	solute carrier family 30 member 8	Homo sapiens	0-4
32723473-3	2020	However, the Zn2+/H+ exchange mechanism of ZnT8 remains unclear due to the lack of high-resolution structures.	Zinc	13-17	solute carrier family 30 member 8	Homo sapiens	43-47
32760844-0	2020	Fabrication of Mn1-x Zn x Fe2O4 ferrofluids from natural sand for magnetic sensors and radar absorbing materials.	Zinc	21-23	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	15-18
32760844-4	2020	The transmission electron microscopy images showed that the filler Mn1-x Zn x Fe2O4 nanoparticles tended to agglomerate in three dimensions.	Zinc	73-75	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	67-70
32760844-7	2020	The secondary particles contributed to the saturation magnetization of the Mn1-x Zn x Fe2O4 ferrofluids.	Zinc	81-83	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	75-78
32760844-8	2020	The Mn1-x Zn x Fe2O4 ferrofluids demonstrated excellent performance as magnetic sensors with high stability, especially compared with MnFe2O4 ferrofluids.	Zinc	10-12	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	4-7
32760844-10	2020	The Mn1-x Zn x Fe2O4 ferrofluids prepared in this work may serve as a future platform for advancing magnetic sensors and radar absorbing materials.	Zinc	10-12	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	4-7
32353602-7	2020	Moreover, Zn could decrease the expression of pro-apoptotic genes (cleaved-caspase-3, caspase-9, and Bax) and increase the expression of anti-apoptotic genes (Bcl-2 and Bcl-xl) to alleviate the cell apoptosis induced by AFB1.	Zinc	10-12	BCL2 associated X, apoptosis regulator	Homo sapiens	101-104
32353602-7	2020	Moreover, Zn could decrease the expression of pro-apoptotic genes (cleaved-caspase-3, caspase-9, and Bax) and increase the expression of anti-apoptotic genes (Bcl-2 and Bcl-xl) to alleviate the cell apoptosis induced by AFB1.	Zinc	10-12	BCL2 apoptosis regulator	Homo sapiens	159-164
32353602-7	2020	Moreover, Zn could decrease the expression of pro-apoptotic genes (cleaved-caspase-3, caspase-9, and Bax) and increase the expression of anti-apoptotic genes (Bcl-2 and Bcl-xl) to alleviate the cell apoptosis induced by AFB1.	Zinc	10-12	BCL2 like 1	Homo sapiens	169-175
31773485-9	2020	ZnG supplementation at 90 mg Zn/kg affected the duodenal mucus by significantly increasing ZnT1, 6, 7, ZIP13, and MT-4 mRNA level (P < 0.05).	Zinc	0-2	metallothionein 4	Gallus gallus	114-118
32483583-1	2020	Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with two types of carbon pronucleophiles (nitromethane as a sp3 carbon pronucleophile and phenylacetylenes as sp carbon pronucleophiles) proceeded to give the 2-substituted tetrahydroquinolines in good yields with 100% atomic utilization without any additional external oxidants.	Zinc	0-8	Sp3 transcription factor	Homo sapiens	169-172
31625053-11	2020	The results showed that the expression of TIMP-1 in the ZnD group was increased, while MMPs were decreased.	Zinc	56-58	tissue inhibitor of metalloproteinase 1	Mus musculus	42-48
31828721-6	2020	Zn also increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3beta (GSK-3beta) phosphorylation and preserves protein kinase C isoforms.	Zinc	0-2	AKT serine/threonine kinase 1	Homo sapiens	55-58
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	catalase	Homo sapiens	92-100
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	catalase	Homo sapiens	102-105
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	210-253
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	255-259
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	solute carrier family 17 member 5	Homo sapiens	449-475
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	solute carrier family 17 member 5	Homo sapiens	477-480
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	alkaline phosphatase, placental	Homo sapiens	515-535
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	alkaline phosphatase, placental	Homo sapiens	537-540
31951514-8	2020	Together the results show that exposure of ESBL-producing E. coli to Zn and Cu reduce horizontal transfer of the blaCMY-2 resistance plasmid by reducing expression of genes involved in conjugation in the plasmid donor strain.	Zinc	69-71	EsbL	Escherichia coli	43-47
31951514-1	2020	The present work addresses the effect of excess levels of ZnCl2 and CuSO4 in the growth medium on the conjugative transfer of plasmids carrying the antibiotic resistance gene blaCMY-2 from extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.	Zinc	58-63	EsbL	Escherichia coli	223-227
32229085-6	2020	A solution NMR study of 15N-labeled NDM-1 showed that A1 disturbed all three residues coordinating the second zinc ion (Zn2) in the active pocket of NDM-1.	Zinc	120-123	NDM-1	Klebsiella pneumoniae	36-41
32685012-8	2020	Meanwhile, ZSZIT degrades under tumor acidic environment, and H2S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug.	Zinc	78-81	catalase	Mus musculus	120-128
32027773-4	2020	We point out that S100B and S100A1 homodimers are not functionally interchangeable and that in a S100A1/S100B heterodimer, S100A1 acts as a negative regulator for the ability of S100B to bind Zn2+ .	Zinc	192-196	S100 calcium binding protein A1	Homo sapiens	97-103
32027773-4	2020	We point out that S100B and S100A1 homodimers are not functionally interchangeable and that in a S100A1/S100B heterodimer, S100A1 acts as a negative regulator for the ability of S100B to bind Zn2+ .	Zinc	192-196	S100 calcium binding protein B	Homo sapiens	104-109
32027773-4	2020	We point out that S100B and S100A1 homodimers are not functionally interchangeable and that in a S100A1/S100B heterodimer, S100A1 acts as a negative regulator for the ability of S100B to bind Zn2+ .	Zinc	192-196	S100 calcium binding protein A1	Homo sapiens	97-103
32027773-4	2020	We point out that S100B and S100A1 homodimers are not functionally interchangeable and that in a S100A1/S100B heterodimer, S100A1 acts as a negative regulator for the ability of S100B to bind Zn2+ .	Zinc	192-196	S100 calcium binding protein B	Homo sapiens	104-109
32027773-5	2020	The Ca2+ and Zn2+ -dependent interactions of S100B with a wide array of proteins form the basis of its activities and have led to the derivation of some initial rules for S100B recognition of protein targets.	Zinc	13-17	S100 calcium binding protein B	Homo sapiens	45-50
32027773-5	2020	The Ca2+ and Zn2+ -dependent interactions of S100B with a wide array of proteins form the basis of its activities and have led to the derivation of some initial rules for S100B recognition of protein targets.	Zinc	13-17	S100 calcium binding protein B	Homo sapiens	171-176
32438294-5	2020	ROS activate presynaptic transient receptor potential melastatin 2 (TRPM2) cation channels and induce extracellular glutamate accumulation in the substantia nigra pars compacta (SNpc), followed by age-related intracellular Zn2+ dysregulation.	Zinc	223-227	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	25-66
32438294-5	2020	ROS activate presynaptic transient receptor potential melastatin 2 (TRPM2) cation channels and induce extracellular glutamate accumulation in the substantia nigra pars compacta (SNpc), followed by age-related intracellular Zn2+ dysregulation.	Zinc	223-227	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	68-73
32438294-8	2020	Postsynaptic TRPM2 channels may be also involved in intracellular Zn2+ dysregulation in the SNpc.	Zinc	66-70	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	13-18
31821694-2	2020	At neutral pH, S100A12 sequesters Zn 2+ with nanomolar affinity, which is further enhanced upon calcium binding.	Zinc	34-36	S100 calcium binding protein A12	Homo sapiens	15-22
31768045-7	2020	Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 microM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.	Zinc	151-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
31768045-7	2020	Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 microM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.	Zinc	151-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	283-287
31768045-7	2020	Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 microM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.	Zinc	151-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
31768045-7	2020	Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 microM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.	Zinc	151-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	283-287
32630615-5	2020	For this purpose, we use Zn2+-stabilized oligomers of the 40-residue form of Abeta (Abeta40) as models of brain Abeta oligomers and two single-domain antibodies (DesAb18-24 and DesAb34-40), designed to bind to epitopes at residues 18-24 and 34-40 of Abeta40, respectively.	Zinc	25-29	amyloid beta precursor protein	Homo sapiens	77-82
32463408-5	2020	Zn and Hg induced G0/G1 cell arrest and apoptotic cell death detected via typical DNA condensation/fragmentation, annexin V staining and caspase 3/7 activity in A549 and MCF-7 cells.	Zinc	0-2	caspase 3	Homo sapiens	137-148
31688305-7	2020	In addition, Zn levels were significantly correlated with homeostasis model assessment of insulin resistance (HOMA-IR) (r = -0.284, P &lt; 0.001), hyaluronic acid (r = -0.230, P &lt; 0.001), branched chain amino acid/tyrosine molar ratio (BTR) (r = 0.278, P &lt; 0.001), FIB-4 index (r = -0.238, P &lt; 0.001), and NAFLD fibrosis score (NFS) (r = -0.261, P &lt; 0.001).	Zinc	13-15	insulin	Homo sapiens	90-97
31688305-10	2020	Serum Zn levels were correlated with nutrition markers and insulin resistance.	Zinc	6-8	insulin	Homo sapiens	59-66
32068056-0	2020	Adsorptive removal of Pb(II) ions from aqueous solutions by thiourea-functionalized magnetic ZnO/nanocellulose composite: Optimization by response surface methodology (RSM).	Zinc	93-96	submaxillary gland androgen regulated protein 3B	Homo sapiens	22-28
32068056-2	2020	In this research, the thiourea-modified magnetic ZnO/nanocellulose composite (TZFNC) with high adsorption capacity and separation efficiency for Pb(II) was prepared successfully, and its physicochemical properties were characterized via XRD, SEM, TEM, AFM, BET, FTIR, XPS, EDAX, Zeta-potential and VSM, respectively.	Zinc	49-52	submaxillary gland androgen regulated protein 3B	Homo sapiens	145-151
32020372-0	2020	Immobilization of lactoperoxidase on ZnO nanoparticles with improved stability.	Zinc	37-40	lactoperoxidase	Homo sapiens	18-33
32020372-1	2020	OBJECTIVES: The study aimed to develop a facile and effectual method to enhance the stability of lactoperoxidase (LPO) by immobilizing it on ZnO Nanoparticles (ZnO NPs).	Zinc	141-144	lactoperoxidase	Homo sapiens	97-112
32020372-1	2020	OBJECTIVES: The study aimed to develop a facile and effectual method to enhance the stability of lactoperoxidase (LPO) by immobilizing it on ZnO Nanoparticles (ZnO NPs).	Zinc	141-144	lactoperoxidase	Homo sapiens	114-117
32020372-1	2020	OBJECTIVES: The study aimed to develop a facile and effectual method to enhance the stability of lactoperoxidase (LPO) by immobilizing it on ZnO Nanoparticles (ZnO NPs).	Zinc	160-163	lactoperoxidase	Homo sapiens	97-112
32020372-1	2020	OBJECTIVES: The study aimed to develop a facile and effectual method to enhance the stability of lactoperoxidase (LPO) by immobilizing it on ZnO Nanoparticles (ZnO NPs).	Zinc	160-163	lactoperoxidase	Homo sapiens	114-117
32020372-2	2020	RESULTS: The successful immobilization of LPO on ZnO NPs was confirmed by using Fourier transform infrared spectroscopy (FT-IR) and field emission scanning electron microscopy (FE-SEM).	Zinc	49-52	lactoperoxidase	Homo sapiens	42-45
32020372-3	2020	The Km values of free LPO and LPO immobilized on ZnO were 53.19, 89.28 mM and their Vmax values were 0.629, 0.46 micromol/mL min, respectively.	Zinc	49-52	lactoperoxidase	Homo sapiens	22-25
32020372-3	2020	The Km values of free LPO and LPO immobilized on ZnO were 53.19, 89.28 mM and their Vmax values were 0.629, 0.46 micromol/mL min, respectively.	Zinc	49-52	lactoperoxidase	Homo sapiens	30-33
32020372-5	2020	The LPO immobilized on ZnO (LPO-ZnO) retained 18% of the initial activity within 30 days at 25  C whereas the free enzyme lost its activity after 7 days at the same temperature.	Zinc	23-26	lactoperoxidase	Homo sapiens	4-7
32020372-5	2020	The LPO immobilized on ZnO (LPO-ZnO) retained 18% of the initial activity within 30 days at 25  C whereas the free enzyme lost its activity after 7 days at the same temperature.	Zinc	32-35	lactoperoxidase	Homo sapiens	4-7
32020372-6	2020	Moreover, evaluation of the thermal stability of LPO at 75  C determined the conservation of 12% of the initial activity of LPO in the LPO-ZnO sample after 60 min whereas the free enzyme lost its activity after 5 min.	Zinc	139-142	lactoperoxidase	Homo sapiens	49-52
32020372-6	2020	Moreover, evaluation of the thermal stability of LPO at 75  C determined the conservation of 12% of the initial activity of LPO in the LPO-ZnO sample after 60 min whereas the free enzyme lost its activity after 5 min.	Zinc	139-142	lactoperoxidase	Homo sapiens	124-127
32020372-7	2020	CONCLUSIONS: According to the present results, ZnO nanoparticles are suitable for the immobilization of LPO.	Zinc	47-50	lactoperoxidase	Homo sapiens	104-107
32229085-6	2020	A solution NMR study of 15N-labeled NDM-1 showed that A1 disturbed all three residues coordinating the second zinc ion (Zn2) in the active pocket of NDM-1.	Zinc	120-123	NDM-1	Klebsiella pneumoniae	149-154
31931255-1	2020	The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFalpha) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP).	Zinc	97-99	interleukin 6	Rattus norvegicus	152-156
31473895-6	2020	The presence of 50 muM Zn significantly decreased (P &lt; 0.05) cellular Cu uptake in HT-29 cells at 0.5:1 Cu:Zn ratio and also the cellular Fe uptake at the ratios 0.5:1, 2:1, and 4:1 Fe:Zn.	Zinc	23-25	latexin	Homo sapiens	19-22
31473895-6	2020	The presence of 50 muM Zn significantly decreased (P &lt; 0.05) cellular Cu uptake in HT-29 cells at 0.5:1 Cu:Zn ratio and also the cellular Fe uptake at the ratios 0.5:1, 2:1, and 4:1 Fe:Zn.	Zinc	110-112	latexin	Homo sapiens	19-22
31473895-6	2020	The presence of 50 muM Zn significantly decreased (P &lt; 0.05) cellular Cu uptake in HT-29 cells at 0.5:1 Cu:Zn ratio and also the cellular Fe uptake at the ratios 0.5:1, 2:1, and 4:1 Fe:Zn.	Zinc	110-112	latexin	Homo sapiens	19-22
32124281-7	2020	Nevertheless, Zn combined with Cd exposure significantly alleviated Cd-induced reproductive toxicity as proved by increased RTW, reappearance of normal histological morphology, increased SOD activity, recovered CAT and GPx activity, and decreased MDA levels in testis.	Zinc	14-16	catalase	Homo sapiens	211-214
31931255-1	2020	The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFalpha) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP).	Zinc	97-99	tumor necrosis factor	Rattus norvegicus	158-166
32297620-3	2020	Zn2+, Cu2+ and Fe3+, in the AD pathology on account of their abnormal accumulation in the Abeta plaques along with an overall dyshomeostasis of these metals in the AD brain was proposed a while back.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	90-95
31884212-5	2020	Elevated temperatures led to an increase in BAF for Cu, Zn, Hg, and Cd (p < 0.05), but no change was observed for As and Pb (p > 0.05).	Zinc	56-58	BAF nuclear assembly factor 1	Homo sapiens	44-47
32207978-6	2020	Our work is an important step in understanding the bonding behavior of Zn under extreme condition and provides valuable reference for experimental synthesis and identification of ZnF3.	Zinc	71-73	zinc finger protein 3	Homo sapiens	179-183
32272780-3	2020	In this article, we review the molecular pathways of Zn2+-induced neurotoxicity based on our and numerous other findings, and demonstrated the implications of the energy production pathway, the disruption of calcium homeostasis, the production of reactive oxygen species (ROS), the endoplasmic reticulum (ER)-stress pathway, and the stress-activated protein kinases/c-Jun amino-terminal kinases (SAPK/JNK) pathway.	Zinc	53-57	mitogen-activated protein kinase 8	Homo sapiens	401-404
31935632-5	2020	In addition, NIR irradiation can also control the release of Zn2+ from the composites.	Zinc	61-65	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	13-16
31935632-7	2020	The controlled release of Zn2+ is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation.	Zinc	26-30	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	86-89
32296959-0	2020	DNA enzyme mediated ratiometric fluorescence assay for Pb(II) ion using magnetic nanosphere-loaded gold nanoparticles and CdSe/ZnS quantum dots.	Zinc	127-130	submaxillary gland androgen regulated protein 3B	Homo sapiens	55-61
31958607-0	2020	ZnCdO2 monolayer - A complex 2D structure of ZnO and CdO monolayers for photocatalytic water splitting driven by visible-light.	Zinc	45-48	cell adhesion associated, oncogene regulated	Homo sapiens	2-5
31958607-2	2020	Here, we predict a two-dimensional ZnCdO2 structure comprising of ZnO and CdO ones to achieve their strengths.	Zinc	66-69	cell adhesion associated, oncogene regulated	Homo sapiens	37-40
31317470-9	2020	Besides, Zn-treated groups showed a significant reduction in the number of apoptotic cells and caspase-3 from that of EMR group, whereas there was an increase in bcl-2 immunopositivity.	Zinc	9-11	caspase 3	Homo sapiens	95-104
31317470-9	2020	Besides, Zn-treated groups showed a significant reduction in the number of apoptotic cells and caspase-3 from that of EMR group, whereas there was an increase in bcl-2 immunopositivity.	Zinc	9-11	BCL2 apoptosis regulator	Homo sapiens	162-167
31317470-11	2020	Zn seems to have protective effects on the EMR by increasing SOD activity and bcl-2 immunopositivity, decreasing lipid peroxidation and caspas-3 immunopositivity.	Zinc	0-2	BCL2 apoptosis regulator	Homo sapiens	78-83
32014991-0	2020	Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase.	Zinc	125-127	optineurin	Homo sapiens	74-84
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Zinc	78-80	MATE efflux family protein	Arabidopsis thaliana	0-4
31721347-1	2020	FRD3 (FERRIC REDUCTASE DEFECTIVE 3) plays a major role in iron (Fe) and zinc (Zn) homeostasis in Arabidopsis.	Zinc	78-80	MATE efflux family protein	Arabidopsis thaliana	6-34
32123071-0	2020	Correction for Jiang et al., Reactivation of Epstein-Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function.	Zinc	124-128	EBNA-1	Human gammaherpesvirus 4	97-102
31883144-3	2020	In this study, two commercial quantum dots (QDs), CdSe/ZnS-MPA and CdSe/ZnS-GSH, were tested for their interactions with P-glycoprotein (P-gp), as well as the relating mechanisms in lung cancer (A549) cells.	Zinc	72-79	ATP binding cassette subfamily B member 1	Homo sapiens	137-141
31410973-6	2020	IL 6 induced STAT3 activation during chronic inflammation and Th17 development suppressed by Zn via attenuating this activation critically controls Th17-cell development.	Zinc	93-95	interleukin 6	Homo sapiens	0-4
31410973-6	2020	IL 6 induced STAT3 activation during chronic inflammation and Th17 development suppressed by Zn via attenuating this activation critically controls Th17-cell development.	Zinc	93-95	signal transducer and activator of transcription 3	Homo sapiens	13-18
31951912-6	2020	The largest differences were observed between the p-methoxyphenyl and p-nitrophenyl-substituted Zn(II) chlorins, undergoing loss of Zn(II) with pseudo first order rate constants of 0.0789 x 10-3 and 3.70 x 10-3 min-1, respectively.	Zinc	70-111	CD59 molecule (CD59 blood group)	Homo sapiens	211-216
31951912-6	2020	The largest differences were observed between the p-methoxyphenyl and p-nitrophenyl-substituted Zn(II) chlorins, undergoing loss of Zn(II) with pseudo first order rate constants of 0.0789 x 10-3 and 3.70 x 10-3 min-1, respectively.	Zinc	96-102	CD59 molecule (CD59 blood group)	Homo sapiens	211-216
31909648-5	2020	In vitro experiments showed that CuInS2/ZnS QDs were taken up by cells, promoted cell viability, enhanced release of tumor necrosis factor-alpha, and decreased the level of interleukin (IL)-6 in response to lipopolysaccharide stimulation.	Zinc	40-43	tumor necrosis factor	Mus musculus	117-144
31909648-5	2020	In vitro experiments showed that CuInS2/ZnS QDs were taken up by cells, promoted cell viability, enhanced release of tumor necrosis factor-alpha, and decreased the level of interleukin (IL)-6 in response to lipopolysaccharide stimulation.	Zinc	40-43	interleukin 6	Mus musculus	173-191
31909648-7	2020	In vivo study showed that CuInS2/ZnS QDs increased the levels of IL-4 on day 1 and enhanced the levels of IL-10 and IL-13 on day 28 in mice.	Zinc	33-36	interleukin 10	Mus musculus	106-111
31909648-7	2020	In vivo study showed that CuInS2/ZnS QDs increased the levels of IL-4 on day 1 and enhanced the levels of IL-10 and IL-13 on day 28 in mice.	Zinc	33-36	interleukin 13	Mus musculus	116-121
32014991-1	2020	Cu/Zn superoxide dismutase (SOD1) is one of the genes implicated in the devastating neurodegenerative disorder amyotrophic lateral sclerosis (ALS).	Zinc	3-5	superoxide dismutase 1	Homo sapiens	28-32
31757708-2	2020	On the addition of Zn2+ ion to the solution of CHP or CHS resulted in a pronounced fluorescence enhancement, accompanying noticeable color change (under UV or daylight), while there was hardly obvious change with other competing metal ions co-existing.	Zinc	19-23	ras homolog family member V	Homo sapiens	47-50
31757708-5	2020	Subsequently, the CHP-Zn2+ or CHS-Zn2+ complexes showed high selectivity fluorescence quenching toward PA by snatching Zn2+ ion from its complex and the binding processes were reversible.	Zinc	22-26	ras homolog family member V	Homo sapiens	18-21
31757708-5	2020	Subsequently, the CHP-Zn2+ or CHS-Zn2+ complexes showed high selectivity fluorescence quenching toward PA by snatching Zn2+ ion from its complex and the binding processes were reversible.	Zinc	34-38	ras homolog family member V	Homo sapiens	18-21
31757708-5	2020	Subsequently, the CHP-Zn2+ or CHS-Zn2+ complexes showed high selectivity fluorescence quenching toward PA by snatching Zn2+ ion from its complex and the binding processes were reversible.	Zinc	34-38	ras homolog family member V	Homo sapiens	18-21
31757562-2	2020	In particular, Au/WS2 and Ag/ZnMOF were linked by thiolate DNA1 and DNA2 strand, respectively, and the Au/WS2-Ag/ZnMOF probe was prepared via hybridization reaction between the two DNAs.	Zinc	29-34	DNA replication helicase/nuclease 2	Homo sapiens	68-72
31970343-1	2020	A new strategy for the highly sensitive electrochemiluminescence (ECL) detection of insulin was developed based on curcumin-conjugated Au nanoparticles wrapped in zeolitic Zn2+-imidazolate cross-linked framework nanoparticles (Au-Cur/ZIF-8) quenching the ECL of CdS-decorated TiO2 nanobelts (CdS@TiO2).	Zinc	172-188	insulin	Homo sapiens	84-91
31940246-9	2020	We further discovered the antioxidant function of Zn through PGC-1alpha/Nrf2 signaling pathway in the endometrial stromal cells.	Zinc	50-52	PPARG coactivator 1 alpha	Homo sapiens	61-71
31940246-9	2020	We further discovered the antioxidant function of Zn through PGC-1alpha/Nrf2 signaling pathway in the endometrial stromal cells.	Zinc	50-52	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
31961070-5	2020	Zn2+ reversibly inhibited the nucleotide-binding ability of PCBP2 in vitro.	Zinc	0-4	poly(rC) binding protein 2	Homo sapiens	60-65
31961070-6	2020	These findings suggest that both PCBP2 and PCBP1 may control the stability of sortilin transcripts by sensing intracellular Zn2+ levels in immune cells.	Zinc	124-128	poly(rC) binding protein 2	Homo sapiens	33-38
31961070-6	2020	These findings suggest that both PCBP2 and PCBP1 may control the stability of sortilin transcripts by sensing intracellular Zn2+ levels in immune cells.	Zinc	124-128	poly(rC) binding protein 1	Homo sapiens	43-48
31961070-6	2020	These findings suggest that both PCBP2 and PCBP1 may control the stability of sortilin transcripts by sensing intracellular Zn2+ levels in immune cells.	Zinc	124-128	sortilin 1	Homo sapiens	78-86
31860779-4	2020	The present study shows that (a) Zn prevents the Cd-induced hormesis effect on MTT reduction in a concentration-dependent manner, without inhibiting Cd-induced ERK1/2 activation; (b) Zn also induces similar hormetic stimulation of MTT-reducing activity but without ERK1/2 activation.	Zinc	33-35	mitogen-activated protein kinase 3	Homo sapiens	265-271
31860779-4	2020	The present study shows that (a) Zn prevents the Cd-induced hormesis effect on MTT reduction in a concentration-dependent manner, without inhibiting Cd-induced ERK1/2 activation; (b) Zn also induces similar hormetic stimulation of MTT-reducing activity but without ERK1/2 activation.	Zinc	183-185	mitogen-activated protein kinase 3	Homo sapiens	265-271
32056106-1	2020	Aberrant structural formations of Cu/Zn superoxide dismutase enzyme (SOD1) are the probable mechanism by which circumscribed mutations in the SOD1 gene cause familial amyotrophic lateral sclerosis (ALS1).	Zinc	37-39	superoxide dismutase 1	Homo sapiens	69-73
32056106-1	2020	Aberrant structural formations of Cu/Zn superoxide dismutase enzyme (SOD1) are the probable mechanism by which circumscribed mutations in the SOD1 gene cause familial amyotrophic lateral sclerosis (ALS1).	Zinc	37-39	superoxide dismutase 1	Homo sapiens	142-146
32056106-1	2020	Aberrant structural formations of Cu/Zn superoxide dismutase enzyme (SOD1) are the probable mechanism by which circumscribed mutations in the SOD1 gene cause familial amyotrophic lateral sclerosis (ALS1).	Zinc	37-39	superoxide dismutase 1	Homo sapiens	198-202
31872196-8	2020	Resveratrol prevented 2-DG-induced mPTP opening and increased intracellular Zn2+ concentration indicated by TMRE and Newport Green DCF fluorescence intensity, which were further abrogated by ERK/GSK-3beta inhibitors and siRNAs.	Zinc	76-80	Eph receptor B1	Rattus norvegicus	191-194
31822409-7	2020	ZnO NPs addition also induced the dose-dependent variations in the superoxide dismutase (SOD) and catalase (CAT) activities, which probably contributed to the suppression of the excess reactive oxygen species (ROS) generations to mitigate nanotoxicity.	Zinc	0-3	catalase	Homo sapiens	98-106
31822409-7	2020	ZnO NPs addition also induced the dose-dependent variations in the superoxide dismutase (SOD) and catalase (CAT) activities, which probably contributed to the suppression of the excess reactive oxygen species (ROS) generations to mitigate nanotoxicity.	Zinc	0-3	catalase	Homo sapiens	108-111
31669277-2	2020	The mutations in Cu/Zn superoxide dismutase (SOD1) causing its misfolding and aggregation are found linked to the motor neuron disorder, amyotrophic lateral sclerosis.	Zinc	20-22	superoxide dismutase 1	Homo sapiens	45-49
31830629-0	2020	Highly selective surface adsorption-induced efficient photodegradation of cationic dyes on hierarchical ZnO nanorod-decorated hydrolyzed PIM-1 nanofibrous webs.	Zinc	104-107	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	137-142
32016568-0	2020	A visual electrochemiluminescence biosensor based on CuInZnS quantum dots for superoxide dismutase detection.	Zinc	53-60	superoxide dismutase 1	Homo sapiens	78-98
32016568-6	2020	In the sensing process, SOD and CuInZnS QDs on a glassy carbon electrode (GCE) competed with each other for hydrogen peroxide to produce superoxide during electrochemical luminescence, thus quenching the ECL signal of CuInZnS QDs.	Zinc	218-225	superoxide dismutase 1	Homo sapiens	24-27
31172426-6	2020	In the film, we found that the spleens of the Zn-deficient group had high levels of proteinaceous material exudation, interstitial broadening, and lymphocyte reduction, with increased collagen, alpha-SMA expression, antioxidants, and oxygen free radicals.	Zinc	46-48	actin alpha 2, smooth muscle, aorta	Mus musculus	194-203
31172426-8	2020	The detection of alpha-SMA, collagen 1, and TGF-beta by fluorescence quantitative PCR revealed that the expression index increased in Zn-deficient mice.	Zinc	134-136	actin alpha 2, smooth muscle, aorta	Mus musculus	17-26
31904211-5	2020	Although both nanomaterials affected the amyloid formation mechanism as well as their disaggregation, ZnO nanoflowers with their sharp edges exhibited the greatest amyloid degradation rate in both model proteins (73% and 35%, respectively) and inhibited the most the insulin fibril growth, while restrained also the fibrillation process in the case of albumin solution.	Zinc	102-105	insulin	Homo sapiens	267-274
32054975-2	2020	The samples are prepared successfully by wet chemical method and the surface morphologies, structures and size of the ZnO samples are characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), BET adsorption isotherm, and Photoluminescence (PL) Spectroscopy.	Zinc	118-121	putative DNA recombination protein Bet	Escherichia coli	252-255
31863908-1	2020	Misfolded Cu/Zn-superoxide dismutase (SOD1) is a pathological species in a subset of amyotrophic lateral sclerosis (ALS).	Zinc	13-26	superoxide dismutase 1	Homo sapiens	38-42
31901962-6	2020	Under the optimal experimental conditions, the linear fluorescence reaction of Zn2+ was good, between 0.2 and 18 muM, and the detection limit was 1.3 x 10-7 M. The low toxicity and excellent membrane permeability of the probe in living cells enable it to be efficiently applied for Zn2+ imaging in cells.	Zinc	79-83	latexin	Homo sapiens	113-116
31901962-6	2020	Under the optimal experimental conditions, the linear fluorescence reaction of Zn2+ was good, between 0.2 and 18 muM, and the detection limit was 1.3 x 10-7 M. The low toxicity and excellent membrane permeability of the probe in living cells enable it to be efficiently applied for Zn2+ imaging in cells.	Zinc	79-82	latexin	Homo sapiens	113-116
31761550-4	2020	We further discovered that surface charge of ZnO NPs were modified after Cd2+ adsorption and the resulting nanoadducts caused more severe damages in placental barriers by causing shed endothelial cells and decreased expressions of tight junction proteins ZO1, occludin, claudin-4 and claudin-8.	Zinc	45-48	tight junction protein 1	Homo sapiens	255-258
31761550-4	2020	We further discovered that surface charge of ZnO NPs were modified after Cd2+ adsorption and the resulting nanoadducts caused more severe damages in placental barriers by causing shed endothelial cells and decreased expressions of tight junction proteins ZO1, occludin, claudin-4 and claudin-8.	Zinc	45-48	claudin 4	Homo sapiens	270-279
31834667-7	2020	The N-(2-methoxyphenyl)iminodiacetate Zn2+ ion sensor has a sensitivity of 1 micromol L-1 within the range of 10-20 micromol L-1 .	Zinc	38-41	L1 cell adhesion molecule	Homo sapiens	86-89
31834667-7	2020	The N-(2-methoxyphenyl)iminodiacetate Zn2+ ion sensor has a sensitivity of 1 micromol L-1 within the range of 10-20 micromol L-1 .	Zinc	38-41	L1 cell adhesion molecule	Homo sapiens	125-128
31918281-12	2020	ZnO NPs could also significantly elevate the expression of Cyt-C, Apaf-1, Caspase-9 and Caspase-3 at mRNA and protein levels, leading to cell death.	Zinc	0-3	cytochrome c, somatic	Homo sapiens	59-64
31918281-12	2020	ZnO NPs could also significantly elevate the expression of Cyt-C, Apaf-1, Caspase-9 and Caspase-3 at mRNA and protein levels, leading to cell death.	Zinc	0-3	apoptotic peptidase activating factor 1	Homo sapiens	66-72
31918281-12	2020	ZnO NPs could also significantly elevate the expression of Cyt-C, Apaf-1, Caspase-9 and Caspase-3 at mRNA and protein levels, leading to cell death.	Zinc	0-3	caspase 3	Homo sapiens	88-97
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	cytochrome c, somatic	Homo sapiens	26-31
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	apoptotic peptidase activating factor 1	Homo sapiens	33-39
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	caspase 3	Homo sapiens	55-64
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	cytochrome c, somatic	Homo sapiens	170-175
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	apoptotic peptidase activating factor 1	Homo sapiens	177-183
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	caspase 3	Homo sapiens	199-208
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	231-234	cytochrome c, somatic	Homo sapiens	170-175
31821933-6	2020	The results have shown that the effect of proinflammatory IL-6 and TNF- cytokines results in the strongest production of the acute phase proteins in the first day on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt.	Zinc	170-178	interleukin 6	Homo sapiens	58-62
31786439-1	2020	The accumulation of the beta-amyloid (Abeta) aggregates induced by Cu2+/Zn2+ in conjunction with toxicity is closely related to Alzheimer"s disease (AD).	Zinc	72-75	amyloid beta precursor protein	Homo sapiens	24-44
31821933-6	2020	The results have shown that the effect of proinflammatory IL-6 and TNF- cytokines results in the strongest production of the acute phase proteins in the first day on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt.	Zinc	170-178	tumor necrosis factor	Homo sapiens	67-70
31898906-1	2020	Recent studies have associated the absence of bound metals (Apo protein) and mutations in the Cu-Zn Human Superoxide Dismutase (SOD1) with Amyotrophic Lateral Sclerosis (ALS) disease, suggesting mechanisms of SOD1 aggregation.	Zinc	97-99	superoxide dismutase 1	Homo sapiens	128-132
31898906-1	2020	Recent studies have associated the absence of bound metals (Apo protein) and mutations in the Cu-Zn Human Superoxide Dismutase (SOD1) with Amyotrophic Lateral Sclerosis (ALS) disease, suggesting mechanisms of SOD1 aggregation.	Zinc	97-99	superoxide dismutase 1	Homo sapiens	209-213
31639234-1	2020	This work shows that hollow and microporous metal-free salen network (H-MSN) can be engineered by Sonogashira coupling of tetraiodo-di(Zn-salen) building blocks with 1,4-diethynylbenzene in the presence of silica templates and by successive Zn and silica etching.	Zinc	135-143	moesin	Homo sapiens	72-75
31710903-9	2020	Availability of As, Cu, Cd and Zn affected dehydrogenase, catalase and urease activities.	Zinc	31-33	catalase	Homo sapiens	58-66
31864632-5	2020	Under optimal conditions, the NH2-MWCNT/ZnO modified screen printed carbon electrode (SPCE) exhibits a broad linear response from 0.2 to 803.4 muM, excellent selectivity of 2.71 muAmuM-1cm-2, and a very low limit of detection (LOD) of 0.002 muM.	Zinc	40-43	latexin	Homo sapiens	143-146
31864632-5	2020	Under optimal conditions, the NH2-MWCNT/ZnO modified screen printed carbon electrode (SPCE) exhibits a broad linear response from 0.2 to 803.4 muM, excellent selectivity of 2.71 muAmuM-1cm-2, and a very low limit of detection (LOD) of 0.002 muM.	Zinc	40-43	latexin	Homo sapiens	181-184
31639234-1	2020	This work shows that hollow and microporous metal-free salen network (H-MSN) can be engineered by Sonogashira coupling of tetraiodo-di(Zn-salen) building blocks with 1,4-diethynylbenzene in the presence of silica templates and by successive Zn and silica etching.	Zinc	135-137	moesin	Homo sapiens	72-75
31984281-4	2020	On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)].	Zinc	210-212	L1 cell adhesion molecule	Homo sapiens	52-55
31850427-5	2020	The Pt2+-exchanged ZIF-8 phase plays a dual role as a metal ion source for L10-PtZn nanoparticles and as a carbonaceous matrix that restrains the aggregation of nanoparticles during thermal treatment.	Zinc	79-83	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	75-78
31850427-6	2020	The L10-PtZn nanoparticles embedded in a hollow carbon nanocage obtained from one-step annealing of Pt2+-exchanged ZIF-8 showed better electrocatalytic activity and durability toward methanol oxidation under acidic electrolyte conditions than those obtained from commercial Pt/C catalysts.	Zinc	8-12	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	4-7
31984281-4	2020	On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)].	Zinc	298-300	L1 cell adhesion molecule	Homo sapiens	52-55
33071257-5	2020	Treatment of the cells with N,N,N",N"-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN), an intracellular chelator of Zn2+, in the presence of 10% fetal bovine serum reduced TAS2R8 promoter activity.	Zinc	121-125	taste 2 receptor member 8	Homo sapiens	177-183
31591766-1	2020	The generation of arylzinc reagents (ArZnX) by direct insertion of zinc into the C-X bond of ArX electrophiles has typically been restricted to iodides and bromides.	Zinc	37-42	aristaless related homeobox	Homo sapiens	93-96
31841322-7	2020	The nature of the magnetic interactions between the LnIII ions and the CoII ions in the "CoLnCo" complexes is deduced by comparing their chiMT values to the sum of chiMT values of the analogous "CoLaCo" and related "ZnLnZn" complexes.	Zinc	216-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-75
30805875-10	2020	There was a positive correlation between Fe-Cu, Zn-Fe, Zn-Cu, CAT-Zn, and CAT-SOD.	Zinc	48-50	catalase	Homo sapiens	74-77
31475889-3	2020	It has been suggested that mechanisms leading to insulin resistance and diabetes and its complications include high intake of refined and energy-rich food, which is presumed to be accompanied by suboptimal intake of trace elements, such as zinc (Zn), selenium (Se), chromium (Cr), and copper (Cu), which are essential and crucial for various biological processes.	Zinc	246-248	insulin	Homo sapiens	49-56
32551440-7	2020	Anemia, hypoalbuminemia, increased FC, and elevated CRP were more frequently present in Zn-insufficient patients with IBD.	Zinc	88-90	C-reactive protein	Homo sapiens	52-55
32551440-9	2020	In multiple linear regression models adjusted for age, gender, and serum albumin, CRP positively correlated with serum Cu (P < 0.001) and the Cu/Zn ratio in both CD and UC (P < 0.001) but not with serum Zn concentrations.	Zinc	145-147	C-reactive protein	Homo sapiens	82-85
32551440-9	2020	In multiple linear regression models adjusted for age, gender, and serum albumin, CRP positively correlated with serum Cu (P < 0.001) and the Cu/Zn ratio in both CD and UC (P < 0.001) but not with serum Zn concentrations.	Zinc	203-205	C-reactive protein	Homo sapiens	82-85
31272355-5	2020	However, Zn2+ is also necessary for the formation of toxic oligomeric forms of amyloid beta, which underlie the pathology of Alzheimer"s disease.	Zinc	9-13	amyloid beta precursor protein	Homo sapiens	79-91
31272355-6	2020	Furthermore, the binding of Zn2+ by amyloid beta causes a disruption of zincergic signaling, and recent studies point to GPR39 and its intracellular targets being affected by amyloid pathology.	Zinc	28-32	amyloid beta precursor protein	Homo sapiens	36-48
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Zinc	130-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31820684-1	2020	BACKGROUND: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (Abeta) and consequently, the progression of Alzheimer"s disease (AD) is well established.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	75-87
31422311-10	2020	Strong correlations between inhalation bioaccessibility in ALF and the mobile (i.e. F1+F2) metal fraction were observed for all tested metals (i.e. (Cu (r = 0.95, p &lt; 0.005), Ni (r = 0.79, p &lt; 0.05), Pb (r = 0.92, p &lt; 0.005) and Zn (r = 0.98, p &lt; 0.005)), n = 9).	Zinc	238-240	general transcription factor IIA subunit 1 like	Homo sapiens	59-62
31820684-1	2020	BACKGROUND: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (Abeta) and consequently, the progression of Alzheimer"s disease (AD) is well established.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	89-94
31698185-1	2020	A "scorpionate" type precursor [bdtbpza = bis(3,5-di-t-butylpyrazol-1-yl)acetate] has been employed to synthesize two mononuclear ZnII and CoII derivatives, namely [Zn(bdtbpza)2 (H2O)2] 2.5CH3OH 2[(CH3)3C-C3H2N2-C(CH3)3] (1) and [Co(bdtbpza)2(CH3OH)4] (2) in good yield.	Zinc	165-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-143
31698185-2	2020	Single crystal X-ray diffraction analysis reveals that in 1, the ZnII atom is tetrahedrally surrounded by a pair of Oacetate atoms of two bis(pyrazol-1-yl)acetate units and two water molecules; while in 2, the CoII atom shows an octahedral environment coordinating a pair of Oacetate atoms of two bis(pyrazol-1-yl)acetate units along with four methanol molecules.	Zinc	65-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	210-214
31383170-2	2020	Moreover, ZnO nanorods (NR1) obtained on the seed layer prepared by oxidation of Zn films exhibited the faster growth rate than those (NR2) synthesized on the seed layer prepared by spin-coating method due to having access to a sufficient amount of Zn2+ ions.	Zinc	10-12	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	24-27
31383170-2	2020	Moreover, ZnO nanorods (NR1) obtained on the seed layer prepared by oxidation of Zn films exhibited the faster growth rate than those (NR2) synthesized on the seed layer prepared by spin-coating method due to having access to a sufficient amount of Zn2+ ions.	Zinc	249-253	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	24-27
31799844-2	2019	L1 displays crystallographic symmetry (orthorhombic, Pccn) higher than its molecular symmetry (point group C1) and also displays supercooling, with a difference in the melting and solidification points of over 100  C. Upon complexation with ZnCl2, L1 engages in both primary cation and secondary anion coordination via hydrogen bonding, and the complex exhibits a room-to-low-temperature single crystal-to-crystal phase transition.	Zinc	241-246	L1 cell adhesion molecule	Homo sapiens	0-2
31846386-4	2020	The increase in the catalyst concentration leads to a decrease in the degradation rate constant, which is the most pronounced in the ZnO/TiO2 and ranges from 0.47 (6) min-1 to 0.25 (3) min-1.	Zinc	133-136	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
31846386-4	2020	The increase in the catalyst concentration leads to a decrease in the degradation rate constant, which is the most pronounced in the ZnO/TiO2 and ranges from 0.47 (6) min-1 to 0.25 (3) min-1.	Zinc	133-136	CD59 molecule (CD59 blood group)	Homo sapiens	185-190
31852371-4	2020	The mRNA levels of ZnTs (ZnT5-7 &amp; ZnT9), ZIPs (ZIP6-10, ZIP13-14), and MT were significantly (p &lt; 0.05) higher in Saos-2 compared to THP-1 and RD.	Zinc	19-23	solute carrier family 30 member 9	Homo sapiens	38-42
31956779-0	2020	Nanochromates MCr2O4 (M = Co, Ni, Cu, Zn): Preparation, Characterization, and Catalytic Activity on the Thermal Decomposition of Fine AP and CL-20.	Zinc	38-40	epithelial membrane protein 1	Homo sapiens	141-146
31842927-2	2019	This study investigated the role of nuclear factor-erythroid 2-related factor (Nrf2) in pulmonary inflammation induced by exposure to ZnO-NPs using Nrf2 null (Nrf2-/-) mice.	Zinc	134-137	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
31842927-6	2019	RESULTS: Exposure to ZnO-NPs dose-dependently increased the number of total cells, macrophages, lymphocytes and eosinophils in BALF both in Nrf2-/- mice and wild type mice, but the magnitude of increase was significantly higher in Nrf2-/- mice than wild type mice.	Zinc	21-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
31674149-1	2019	Coordination complexes of an olefinic molecule (PIP) containing pyridine and imidazopyridine moieties with Zn(II)/Ni(II) metal salts were shown to exhibit appreciable proton conductivity.	Zinc	107-113	prolactin induced protein	Homo sapiens	48-51
31842927-6	2019	RESULTS: Exposure to ZnO-NPs dose-dependently increased the number of total cells, macrophages, lymphocytes and eosinophils in BALF both in Nrf2-/- mice and wild type mice, but the magnitude of increase was significantly higher in Nrf2-/- mice than wild type mice.	Zinc	21-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	231-235
31842927-10	2019	The results suggest that Nrf2 play a role in negative regulation on ZnO-NP exposure-induced neutrophil migration, but does not demonstrate that the regulation is through suppression of oxidative stress.	Zinc	68-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
31733214-3	2019	In this work, we synthesized a complex of polymer-coated CdSe/ZnS quantum dots, substituted phthalocyanines and human transferrin.	Zinc	62-65	transferrin	Homo sapiens	118-129
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	266-299
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	301-306
31544269-0	2019	The Role of LiBr and ZnBr2 on the Coupling of sp2-Hybridized Oxidative Addition Partners with sp3-Hybridized Organozincs.	Zinc	21-26	Sp2 transcription factor	Homo sapiens	46-49
31544269-0	2019	The Role of LiBr and ZnBr2 on the Coupling of sp2-Hybridized Oxidative Addition Partners with sp3-Hybridized Organozincs.	Zinc	21-26	Sp3 transcription factor	Homo sapiens	94-97
31824152-8	2019	Results: We found that 20 mg/kg PEG-InP/ZnS QDs increased the number of neutrophils and the levels of IL-6 in both peritoneal lavage fluids and blood, which indicated acute phase inflammation in the mice.	Zinc	40-43	interleukin 6	Mus musculus	102-106
31824152-9	2019	PEG-InP/ZnS QDs also activated the BMMs and increased the production of IL-6.	Zinc	8-11	interleukin 6	Mus musculus	72-76
31824152-10	2019	In addition, PEG-InP/ZnS QDs triggered oxidative stress and the ER stress-related PERK-ATF4 pathway in the BMMs.	Zinc	21-24	activating transcription factor 4	Mus musculus	87-91
31302864-6	2019	The effect of Zn was investigated on the gene expression of MT1-A before and after Zn supplementation.	Zinc	14-16	metallothionein 1A	Homo sapiens	60-65
31302864-8	2019	In the cohort of ASD patients, the genetic expression of MT-1 was higher after Zn therapy than before the treatment.	Zinc	79-81	metallothionein 1A	Homo sapiens	57-61
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Zinc	17-19	toll-like receptor 2	Rattus norvegicus	77-114
31827626-7	2019	Conclusion: This study indicates that Zn supplementation with a restricted calorie diet has favorable effects in reducing anthropometric measurements, inflammatory markers, insulin resistance and appetite in individuals with obesity, and may play an effective role in the treatment of obesity.Trial registration This clinical trial was registered at clinicaltrials.gov at the U.S. National Library of Medicine (NCT02516475).	Zinc	38-40	insulin	Homo sapiens	173-180
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Zinc	17-19	tumor necrosis factor	Rattus norvegicus	143-170
31173363-1	2019	It is well known that zinc ion (Zn2+ ) can regulate the biological activity of growth hormone (GH).	Zinc	32-36	growth hormone 1	Homo sapiens	79-93
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	160-164	growth hormone 1	Homo sapiens	126-128
31173363-1	2019	It is well known that zinc ion (Zn2+ ) can regulate the biological activity of growth hormone (GH).	Zinc	32-36	growth hormone 1	Homo sapiens	95-97
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	192-196	growth hormone 1	Homo sapiens	126-128
31173363-6	2019	On this basis, we further explored how Zn2+ regulates the biological activity of GH/GHR.	Zinc	39-43	growth hormone 1	Homo sapiens	81-83
31173363-11	2019	This study lays a foundation for further exploration of the biological effects of Zn2+ on GH.	Zinc	82-86	growth hormone 1	Homo sapiens	90-92
31173363-2	2019	However, until now, the mechanism by which Zn2+ regulates GH biological activity remains unclear.	Zinc	43-47	growth hormone 1	Homo sapiens	58-60
31173363-3	2019	In the current study, we first performed molecular docking between Zn2+ and porcine GH (pGH) using computational biology.	Zinc	67-71	growth hormone 1	Homo sapiens	84-86
31173363-4	2019	We then explored the effect of Zn2+ on the GH signaling ability in the cell model expressing porcine growth hormone receptor (GHR).	Zinc	31-35	growth hormone 1	Homo sapiens	43-45
31827651-9	2019	The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for type 1 diabetes in both children and adults.	Zinc	132-138	insulin	Homo sapiens	85-130
31346859-9	2019	Furthermore, treatment with Zn caused a significant reduction in GSH levels as well as a decrease in superoxide dismutase and catalase activities.	Zinc	28-30	catalase	Mus musculus	126-134
31526921-8	2019	The PC2 was Pb, Zn and Cu which were mainly caused by anthropogenic mining activities.	Zinc	16-18	polycystin 2, transient receptor potential cation channel	Homo sapiens	4-7
31675205-3	2019	To this end, a zinc(II)-based CP (ZnCP) with adenine as a bridge ligand was employed to integrate with alkaline phosphatase (ALP) and anticarcinoembryonic antigen (anti-CEA) antibody, which produces ALP/anti-CEA@ZnCPs.	Zinc	15-23	alkaline phosphatase, placental	Homo sapiens	103-123
31675205-3	2019	To this end, a zinc(II)-based CP (ZnCP) with adenine as a bridge ligand was employed to integrate with alkaline phosphatase (ALP) and anticarcinoembryonic antigen (anti-CEA) antibody, which produces ALP/anti-CEA@ZnCPs.	Zinc	15-23	alkaline phosphatase, placental	Homo sapiens	125-128
31675205-3	2019	To this end, a zinc(II)-based CP (ZnCP) with adenine as a bridge ligand was employed to integrate with alkaline phosphatase (ALP) and anticarcinoembryonic antigen (anti-CEA) antibody, which produces ALP/anti-CEA@ZnCPs.	Zinc	15-23	CEA cell adhesion molecule 3	Homo sapiens	169-172
31675205-3	2019	To this end, a zinc(II)-based CP (ZnCP) with adenine as a bridge ligand was employed to integrate with alkaline phosphatase (ALP) and anticarcinoembryonic antigen (anti-CEA) antibody, which produces ALP/anti-CEA@ZnCPs.	Zinc	15-23	alkaline phosphatase, placental	Homo sapiens	199-202
31675205-3	2019	To this end, a zinc(II)-based CP (ZnCP) with adenine as a bridge ligand was employed to integrate with alkaline phosphatase (ALP) and anticarcinoembryonic antigen (anti-CEA) antibody, which produces ALP/anti-CEA@ZnCPs.	Zinc	15-23	CEA cell adhesion molecule 3	Homo sapiens	208-211
31072216-8	2019	Docking of 10a in the binding site of HDAC6 attributed the activity of 10a to pi-pi stacking with the amino acids of the hydrophobic channel of HDAC6 and capture of zinc metal in bidentate fashion.	Zinc	165-175	histone deacetylase 6	Homo sapiens	38-43
31657415-1	2019	The indyl anion, K[In(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) reacts with group 12 compounds M(BDIR)Cl (M = Zn, Cd; BDI = [HC{C(Me)NR}2]-, R = 2,4,6-Me3C6H2 (Mes), Dipp) to afford the heterobimetallic compounds (NONDipp)In-M(BDIR) that contain the first In-Zn and In-Cd bonds.	Zinc	130-132	nudix hydrolase 3	Homo sapiens	25-29
31657415-1	2019	The indyl anion, K[In(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) reacts with group 12 compounds M(BDIR)Cl (M = Zn, Cd; BDI = [HC{C(Me)NR}2]-, R = 2,4,6-Me3C6H2 (Mes), Dipp) to afford the heterobimetallic compounds (NONDipp)In-M(BDIR) that contain the first In-Zn and In-Cd bonds.	Zinc	130-132	nudix hydrolase 3	Homo sapiens	36-40
31657415-1	2019	The indyl anion, K[In(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) reacts with group 12 compounds M(BDIR)Cl (M = Zn, Cd; BDI = [HC{C(Me)NR}2]-, R = 2,4,6-Me3C6H2 (Mes), Dipp) to afford the heterobimetallic compounds (NONDipp)In-M(BDIR) that contain the first In-Zn and In-Cd bonds.	Zinc	279-281	nudix hydrolase 3	Homo sapiens	25-29
31657415-1	2019	The indyl anion, K[In(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2-, Dipp = 2,6-iPr2C6H3) reacts with group 12 compounds M(BDIR)Cl (M = Zn, Cd; BDI = [HC{C(Me)NR}2]-, R = 2,4,6-Me3C6H2 (Mes), Dipp) to afford the heterobimetallic compounds (NONDipp)In-M(BDIR) that contain the first In-Zn and In-Cd bonds.	Zinc	279-281	nudix hydrolase 3	Homo sapiens	36-40
31657415-2	2019	The reactivity of the In-Zn bonds towards organic azides, R"N3 (R" = Mes, Dipp, Ph) was investigated.	Zinc	25-27	nudix hydrolase 3	Homo sapiens	74-78
31694210-7	2019	Normal BMP-2 and Runx2 transcriptions are observed in both Si-TCP and Zn-TCP scaffolds at the initial time point, as demonstrated by RT-qPCR.	Zinc	70-72	RUNX family transcription factor 2	Homo sapiens	17-22
31781168-1	2019	Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isolated sporadic cases (sALS).	Zinc	102-104	superoxide dismutase 1	Homo sapiens	127-131
31781168-1	2019	Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isolated sporadic cases (sALS).	Zinc	102-104	superoxide dismutase 1	Homo sapiens	240-244
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31788592-6	2019	Mg-TNT, Zn-TNT, and K-TNT showed higher MB removal percentages (97%) after 45 min, while Ca-TNT, Cr-TNT, Ce(III)-TNT, Mo-TNT, La-TNT, and Na-TNT showed removal efficiencies of 95, 84, 95, 96, 94, and 96% after 65, 1200, 120, 300, 180, and 105 min, respectively.	Zinc	8-10	chromosome 16 open reading frame 82	Homo sapiens	11-14
31592647-2	2019	Two bioenzymes, glucose oxidase (GOx) and alkaline phosphatase (ALP) were chosen for the enzymatic preparation of core-satellite or core-shell type CdSe/ZnS@Au hybrid nanostructures.	Zinc	153-156	alkaline phosphatase, placental	Homo sapiens	42-62
31592647-2	2019	Two bioenzymes, glucose oxidase (GOx) and alkaline phosphatase (ALP) were chosen for the enzymatic preparation of core-satellite or core-shell type CdSe/ZnS@Au hybrid nanostructures.	Zinc	153-156	alkaline phosphatase, placental	Homo sapiens	64-67
31387710-1	2019	Herein, a zinc ion (Zn2+)-triggered aggregation induced emission enhancement (AIEE) fluorescence "on-off-on" nanoswitch was fabricated for inorganic pyrophosphate (PPi) and inorganic pyrophosphatase (PPase) activity detection.	Zinc	20-24	inorganic pyrophosphatase 1	Homo sapiens	173-198
31387710-1	2019	Herein, a zinc ion (Zn2+)-triggered aggregation induced emission enhancement (AIEE) fluorescence "on-off-on" nanoswitch was fabricated for inorganic pyrophosphate (PPi) and inorganic pyrophosphatase (PPase) activity detection.	Zinc	20-24	inorganic pyrophosphatase 1	Homo sapiens	200-205
31387710-5	2019	When PPase was introduced, PPi was hydrolyzed and release Zn2+, resulting in aggregated Au NCs along with enhanced fluorescence again (off-on).	Zinc	58-62	inorganic pyrophosphatase 1	Homo sapiens	5-10
31694210-9	2019	These results demonstrate the effects of Si and Zn doped porous beta-TCP scaffolds on the upregulation of osteoblast marker gene expression including OPG, RANKL, BMP-2, and Runx2, indicating the role of trace elements on the effective regulation of late-stage osteoblast cell differentiation markers.	Zinc	48-50	RUNX family transcription factor 2	Homo sapiens	173-178
31387710-8	2019	Furthermore, the as-prepared Zn2+-triggered AIEE nanoswitch was successfully used for quantitative analysis of PPase activity in human serum with satisfactory spiked recoveries, and applied for the inhibitors screening.	Zinc	29-33	inorganic pyrophosphatase 1	Homo sapiens	111-116
31119555-6	2019	The present study indicates that rapid influx of extracellular Zn2+ into dopaminergic neurons via PQ-induced TRPM2 cation channel activation accelerates nigrostriatal dopaminergic degeneration in aged rats.	Zinc	63-67	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	109-114
31328268-7	2019	Expression of metallothionein messenger RNA of jejunum in the group fed a diet containing Zn-Met (80 mg Zn/kilogram diet) was higher (P < 0.05) than that in the control.	Zinc	90-92	metallothionein 4	Gallus gallus	14-29
31328268-8	2019	CONCLUSION: These results indicated that Zn-Met has positive effects on the Zn status of liver, duodenum, and jejunum, intestinal morphology, and metallothionein messenger RNA expression in jejunum of laying hens compared with ZnSO4 .	Zinc	41-43	metallothionein 4	Gallus gallus	146-161
31119555-1	2019	On the basis of the evidence that paraquat (PQ)-induced extracellular Zn2+ influx causes PQ-induced pathogenesis in the substantia nigra pars compacta (SNpc) of rats, we postulated that the transient receptor potential melastatin 2 (TRPM2) cation channels activated with PQ-induced reactive oxygen species (ROS) are linked with extracellular glutamate accumulation in the SNpc, followed by age-related intracellular Zn2+ dysregulation.	Zinc	70-74	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	190-231
31340034-5	2019	In WT and 35S::FLAG-GSNOR1, GSNOR was inactivated by Zn, and Zn-induced H2O2 is directly involved in the GSNOR activity loss.	Zinc	53-55	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	28-33
31119555-1	2019	On the basis of the evidence that paraquat (PQ)-induced extracellular Zn2+ influx causes PQ-induced pathogenesis in the substantia nigra pars compacta (SNpc) of rats, we postulated that the transient receptor potential melastatin 2 (TRPM2) cation channels activated with PQ-induced reactive oxygen species (ROS) are linked with extracellular glutamate accumulation in the SNpc, followed by age-related intracellular Zn2+ dysregulation.	Zinc	70-74	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	233-238
31119555-1	2019	On the basis of the evidence that paraquat (PQ)-induced extracellular Zn2+ influx causes PQ-induced pathogenesis in the substantia nigra pars compacta (SNpc) of rats, we postulated that the transient receptor potential melastatin 2 (TRPM2) cation channels activated with PQ-induced reactive oxygen species (ROS) are linked with extracellular glutamate accumulation in the SNpc, followed by age-related intracellular Zn2+ dysregulation.	Zinc	416-420	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	190-231
31340034-5	2019	In WT and 35S::FLAG-GSNOR1, GSNOR was inactivated by Zn, and Zn-induced H2O2 is directly involved in the GSNOR activity loss.	Zinc	61-63	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	20-25
31340034-8	2019	Our data collectively show that Zn-induced H2O2 may influence its own level, which involves GSNOR inactivation-triggered SNO signaling.	Zinc	32-34	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	92-97
31652702-0	2019	Metal (Pb, Cu, Cd, and Zn) Transfer along Food Chain and Health Risk Assessment through Raw Milk Consumption from Free-Range Cows.	Zinc	23-25	Weaning weight-maternal milk	Bos taurus	92-96
31400593-6	2019	An EFI of 100 mV cm-1 could alleviate the oxidative damage in plant cells by promoting the synthesis of reduced glutathione and an activity increase of catalase, thus increasing the phytoextraction for Cu, Zn and Cd.	Zinc	206-208	catalase	Homo sapiens	152-160
31420932-2	2019	Herein, we describe the synthesis from hydrogenobyric acid of zincobyric acid (Znby) and zincobalamin (Znbl), the Zn-analogues of the natural cobalt-corrins cobyric acid and vitamin B12 , respectively.	Zinc	79-81	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	182-185
31641116-0	2019	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals.	Zinc	63-67	mucolipin TRP cation channel 1	Homo sapiens	38-44
31641116-3	2019	Using GZnP3 as well as GZnP3-derived vesicular targeted probes, we provide the first direct evidence that Zn2+ can be released from endolysosomal vesicles to the cytosol in primary hippocampal neurons through the TRPML1 channel.	Zinc	106-110	mucolipin TRP cation channel 1	Homo sapiens	213-219
31641116-4	2019	Such TRPML1-mediated Zn2+ signals are distinct from Ca2+ in that they are selectively present in neurons, sustain longer, and are significantly higher in neurites as compared to the soma.	Zinc	21-25	mucolipin TRP cation channel 1	Homo sapiens	5-11
31586028-5	2019	Additionally, interaction with the caspase-7 exosite involves both the Zn3 and BRCT domains of PARP-1 and is mediated by RNA.	Zinc	71-74	poly(ADP-ribose) polymerase 1	Homo sapiens	95-101
31444841-4	2019	Through tuning both composition and pores, the 3D N-doped nanocarbon with a high sp3 /sp2 carbon ratio on the surface exhibits a superior electrocatalytic performance for the ORR compared to that of the commercial Pt/C in Zn-air batteries.	Zinc	222-224	Sp3 transcription factor	Homo sapiens	81-84
31671672-6	2019	The best result achieved for Zn(II) removal after 24 h was 95.5% for the ternary Zn(II)-Cd(II)-Ni(II) solution for PIM doped (4).	Zinc	29-35	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	115-118
31671672-6	2019	The best result achieved for Zn(II) removal after 24 h was 95.5% for the ternary Zn(II)-Cd(II)-Ni(II) solution for PIM doped (4).	Zinc	81-101	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	115-118
31464077-3	2019	The synthesis of ultrasmall and ordered L10 -PtCo nanoparticle ORR catalysts further doped with a few percent of metals (W, Ga, Zn) is reported.	Zinc	128-130	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	40-43
31247877-1	2019	According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn ions, bound to the amyloid-beta (Abeta) peptides are implicated in Alzheimer"s disease (AD), a widespread neurodegenerative disease.	Zinc	71-73	amyloid beta precursor protein	Homo sapiens	93-105
31247877-1	2019	According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn ions, bound to the amyloid-beta (Abeta) peptides are implicated in Alzheimer"s disease (AD), a widespread neurodegenerative disease.	Zinc	71-73	amyloid beta precursor protein	Homo sapiens	107-112
31283866-1	2019	Three new "push-pull" A3 B Zn(II)porphyrin dyes having meso-pyrenyl, carbazolyl and phenothiazine as electron donors (A) and phenylcarboxylic acid as acceptor/anchor (B) were synthesized and utilized for DSSC application.	Zinc	27-29	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	22-26
31619728-10	2019	Mycorrhizal fungi conferred tolerance to soil Zn and P deficiency and this could be linked to the induction of the ZIP transporter gene MtZIP5, and the PT gene MtPT4.	Zinc	46-48	ascorbate transporter, chloroplastic	Medicago truncatula	152-154
31326861-5	2019	Here, we report a simple approach to quantitative detection of soluble Abeta species using N-(6-(benzothiazol-2-yl)pyridin-3-yl)-5-(dimethylamino)naphthalene-1-sulfonamide (BPNS) as a ratiometric fluorescence Zn2+ probe.	Zinc	209-213	amyloid beta precursor protein	Homo sapiens	71-76
31578407-10	2019	Optimum pH and temperature for mobilization was recorded at pH 5 (ZnO) and 37  C (ZnCO3) by CDK25, whereas, optimum zinc concentration for mobilization was recorded at 0.05% (ZnO) by CDK15.	Zinc	175-178	cyclin dependent kinase 15	Bos taurus	183-188
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	95-99	amyloid beta precursor protein	Homo sapiens	75-80
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	95-99	amyloid beta precursor protein	Homo sapiens	118-123
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	175-179	amyloid beta precursor protein	Homo sapiens	75-80
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	175-179	amyloid beta precursor protein	Homo sapiens	118-123
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	175-179	amyloid beta precursor protein	Homo sapiens	75-80
31326861-6	2019	This ratiometric fluorescence assay is based on the competition of soluble Abeta with BPNS for Zn2+, that is, soluble Abeta species with higher chelation affinity can capture Zn2+ from BPNS-Zn2+ adduct, thereby reactivating the ratiometric fluorescence response of BPNS.	Zinc	175-179	amyloid beta precursor protein	Homo sapiens	118-123
31326861-7	2019	BPNS exhibited perfect linear relationship (R2 = 0.998) in accordance with the concentration of soluble Abeta in the presence of Zn2+.	Zinc	129-133	amyloid beta precursor protein	Homo sapiens	104-109
31330363-8	2019	Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity.	Zinc	34-36	nitric oxide synthase 2	Homo sapiens	122-127
31026992-5	2019	The erosion rates of the Zn-based polyurethane SPC films were determined by measuring changes in the film thickness after dynamic immersion tests.	Zinc	25-27	proline rich protein gene cluster	Homo sapiens	47-50
30941734-6	2019	It appears that cells of the immature cortex express a wide diversity of actors involved in Zn homeostasis with Zip7, SOD1, and metallothioneins being the most abundant transcripts throughout corticogenesis.	Zinc	92-94	superoxide dismutase 1, soluble	Mus musculus	118-122
31349449-6	2019	Zn-doped cryogels supported migration of human skin fibroblasts (HSF); only upper Zn content of 11.8 x 103 ppm in the scaffold caused c.a.	Zinc	0-2	interleukin 6	Homo sapiens	65-68
31349449-8	2019	Zn ions solubilized in culture medium were more active towards HSF (IC50   0.3 mM).	Zinc	0-2	interleukin 6	Homo sapiens	63-66
29421993-1	2019	Objectives: This study was aimed to evaluate the effects of zinc (Zn) supplementation on serum levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with diabetic retinopathy (DR).	Zinc	66-68	vascular endothelial growth factor A	Homo sapiens	105-139
31364019-11	2019	In conclusion, increasing levels of Se and Zn decreases the intensity of inflammation as measured by IL-6, IL-10 and TNF-alpha levels.	Zinc	43-45	interleukin 6	Homo sapiens	101-105
31364019-11	2019	In conclusion, increasing levels of Se and Zn decreases the intensity of inflammation as measured by IL-6, IL-10 and TNF-alpha levels.	Zinc	43-45	tumor necrosis factor	Homo sapiens	117-126
29421993-7	2019	Levels of VEGF correlated negatively with levels of Zn and positively with BDNF and NGF.	Zinc	52-54	vascular endothelial growth factor A	Homo sapiens	10-14
32954262-5	2019	In this study, we show that the deletion of YPK9 (the yeast orthologue of ATP13A2) in Saccharomyces cerevisiae leads to growth impairment in the presence of Zn2+, Mn2+, Co2+ and Ni2+, with the strongest phenotype being observed in the presence of zinc.	Zinc	157-161	putative acid anhydride hydrolase	Saccharomyces cerevisiae S288C	44-48
31475275-2	2019	In an attempt to understand the impact of the coordination of Zn(ii) and Cu(ii) on the biological activity of calcitermin, we mutated each of the histidines with an alanine and studied the thermodynamics, binding mode and antimicrobial activity of wild type calcitermin and its H9A, H11A and H13A mutants and their Zn(ii) and Cu(ii) complexes.	Zinc	315-321	S100 calcium binding protein A12	Homo sapiens	110-121
31475275-2	2019	In an attempt to understand the impact of the coordination of Zn(ii) and Cu(ii) on the biological activity of calcitermin, we mutated each of the histidines with an alanine and studied the thermodynamics, binding mode and antimicrobial activity of wild type calcitermin and its H9A, H11A and H13A mutants and their Zn(ii) and Cu(ii) complexes.	Zinc	62-68	S100 calcium binding protein A12	Homo sapiens	110-121
31762996-5	2019	The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-alpha(TNF-alpha), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1).	Zinc	51-56	tumor necrosis factor	Rattus norvegicus	171-180
31129334-5	2019	During the nitrate reduction by Zn-Ag/hv/HCOOH process, rapid reduction of NO3- to NO2- was primarily caused by ZnAg bimetal.	Zinc	32-34	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
31762996-5	2019	The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-alpha(TNF-alpha), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1).	Zinc	51-56	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	238-264
31762996-5	2019	The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-alpha(TNF-alpha), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1).	Zinc	51-56	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	266-269
31762996-5	2019	The results showed that the combination of LBP and ZnSO4 could significantly decrease the levels of triglyceride (TG), total cholesterol (TC), tumor necrosis factor-alpha(TNF-alpha), malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the activity of enzyme subtype 2E1 (CYP2E1).	Zinc	51-56	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	312-318
31491970-7	2019	Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma.	Zinc	103-105	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
31326241-6	2019	These studies show preference for the HDAC6 active site by chelating the Zn center, in contrast with other ineffective hispolon derivatives, that establish only a single bond to the metal center.	Zinc	73-75	histone deacetylase 6	Homo sapiens	38-43
31348572-4	2019	Owing to the desired composition and formation of the heterostructures, the resulting MnO/Co/PGC exhibits superior activity and stability toward both OER and ORR, which makes it an efficient air cathode for the rechargeable Zn-air battery.	Zinc	224-226	progastricsin	Homo sapiens	93-96
32042215-7	2019	While ZnO-NPs caused depletion of both wild-type and gain-of-function (GOF) mutant p53 protein in ovarian cancer cells, their ability to induce apoptosis was found to be independent of the p53-mutation status in these cells.	Zinc	6-9	tumor protein p53	Homo sapiens	83-86
30904440-4	2019	The assay is demonstrated for quantification of Cu2+ and Zn2+ ions in human Cu, Zn superoxide dismutases (SOD1s); however, the method is general and can be applied to various combinations of metal ions.	Zinc	57-61	superoxide dismutase 1	Homo sapiens	106-110
31270951-6	2019	In addition, combined SFN and Zn treatment increased Nrf2 function and MT expression in the heart of OVE mice to a greater extent than SFN or Zn alone.	Zinc	30-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
31270951-7	2019	This indicates that the dual activation of Nrf2 and MT by combined treatment with SFN and Zn may be more effective than monotherapy at preventing the development of DCM via complementary, additive mechanisms.	Zinc	90-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
31345348-7	2019	Multiple regression analyses revealed that DNA methylation of LINE1, Nrf2, OGG1, and PARP1 was associated with potentially toxic (As, Hg, Mn, Mo, and Pb) and essential (Cu, Se, and Zn) elements, and with their interactions.	Zinc	181-183	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
31345348-7	2019	Multiple regression analyses revealed that DNA methylation of LINE1, Nrf2, OGG1, and PARP1 was associated with potentially toxic (As, Hg, Mn, Mo, and Pb) and essential (Cu, Se, and Zn) elements, and with their interactions.	Zinc	181-183	poly(ADP-ribose) polymerase 1	Homo sapiens	85-90
31345366-3	2019	Acetylcholinesterase inhibitors (AChEI) are commonly used as AD treatment to improve cognitive function, but their effect on Zn homeostasis is still unexplored.	Zinc	125-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
31469368-9	2019	Overexpression of zatp7a made ZFL cells more sensitive to Zn.	Zinc	58-60	ATPase copper transporting alpha	Danio rerio	18-24
31377220-3	2019	Low levels of Zn as well as high levels of Cu, Mn, and Fe participate in the activation of signaling pathways of the inflammatory, oxidative and nitrosative stress (IO&NS) response, including nuclear factor kappa B and activator protein-1.	Zinc	14-16	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	219-238
31330099-9	2019	Finally, we demonstrate induction of PGRN expression by fast-on/fast-off, highly potent, macrocyclic HDAC inhibitors with ethyl ketone or ethyl ester Zn2+ binding groups.	Zinc	150-154	granulin precursor	Homo sapiens	37-41
31140779-10	2019	These key features make 4 a potential MFM platform to develop therapeutic agents for metal (Cu, Zn and Fe)-dependent and -independent multifaceted Abeta toxicity of AD.	Zinc	96-98	amyloid beta precursor protein	Homo sapiens	147-152
31416263-14	2019	Of note, although concentrations of Se and Zn in the raw milk were higher in Alberta compared with WA, their concentrations were still below their respective MRLs.	Zinc	43-45	Weaning weight-maternal milk	Bos taurus	57-61
30382478-2	2019	Our objective was to determine the effects of supplemental Zn sources, in excess of minimal requirements, on markers of mammary epithelial integrity in blood and in milk as well as the heat stability of milk in mid-lactation cows.	Zinc	59-61	Weaning weight-maternal milk	Bos taurus	165-169
31035130-5	2019	Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) &gt; Ca(II) &gt; Co(II) &gt; Zn(II).	Zinc	135-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	107-110
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	94-97
30913819-4	2019	The presence of Zn(II) metal ion is determined through the band at 150 cm-1 (T2g(1) phonon mode), which is not present in the pure Co-ferrite, a blue-shift of the Eg vibrational mode depending on Zn(II)/Co(II) cationic distribution and a shoulder at ~250 cm-1, which appears when zinc enters in the structure, and a broadening and a red-shift in the A1g phonon mode is observed in Raman spectra of 2-4 samples.	Zinc	16-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	107-110
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	107-110
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	107-110
31220758-4	2019	When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg L-1, 2.83 mg L-1, and 114.42 mg L-1 to 0.027 mg L-1, 0.59 mg L-1, and 0.16 mg L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment.	Zinc	43-45	L1 cell adhesion molecule	Homo sapiens	107-110
31370315-0	2019	Zn2+ Interaction with Amyloid-Beta: Affinity and Speciation.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	22-34
31370315-1	2019	Conflicting values, obtained by different techniques and often under different experimental conditions have been reported on the affinity of Zn2+ for amyloid-beta, that is recognized as the major interaction responsible for Alzheimer"s disease.	Zinc	141-145	amyloid beta precursor protein	Homo sapiens	150-162
31379409-8	2019	In addition, sublethal treatment with PAM induced phosphorylation of ATM kinase, accumulation of p53 protein, and expression of p21 and GADD45A, which are known p53 target genes, in a Zn2+-dependent manner.	Zinc	184-188	tumor protein p53	Homo sapiens	97-100
31346193-4	2019	In addition, we found that Zn and mast cells induce IL-6 production from inflammatory cells such as skin fibroblasts and promote wound healing, a process that involves inflammation.	Zinc	27-29	interleukin 6	Mus musculus	52-56
31346193-5	2019	Zn induces the production of a variety of pro-inflammatory cytokines including IL-6 through signaling pathways mediated by the Zn receptor GPR39.	Zinc	0-2	interleukin 6	Mus musculus	79-83
31346193-7	2019	Thus, our results show that Zn and mast cells play a critical role in wound healing through activation of the GPR39/IL-6 signaling axis.	Zinc	28-30	interleukin 6	Mus musculus	116-120
31636949-4	2019	Through systematic profiling studies, we show that human SIRT3 displays class-selective histone de-beta-hydroxybutyrylase activities with preference for H3 K4, K9, K18, K23, K27, and H4K16, but not for H4 K5, K8, K12, which distinguishes it from the Zn-dependent HDACs.	Zinc	250-252	sirtuin 3	Homo sapiens	57-62
31146164-8	2019	Silencing of KCC3, but not KCC4, expression abolished Zn2+-dependent K+/Cl- co-transport, suggesting that KCC3 is mediating upregulated NH4+ transport.	Zinc	54-58	solute carrier family 12 member 6	Homo sapiens	13-17
31146164-8	2019	Silencing of KCC3, but not KCC4, expression abolished Zn2+-dependent K+/Cl- co-transport, suggesting that KCC3 is mediating upregulated NH4+ transport.	Zinc	54-58	solute carrier family 12 member 6	Homo sapiens	106-110
31146164-10	2019	Importantly, silencing of either ZnR/GPR39 or KCC3 attenuated Zn2+-dependent scratch closure.	Zinc	62-66	solute carrier family 12 member 6	Homo sapiens	46-50
31146164-11	2019	Thus, a novel link between KCC3 and Zn2+, via ZnR/GPR39, promotes breast cancer cell migration and proliferation.	Zinc	36-40	solute carrier family 12 member 6	Homo sapiens	27-31
31379409-8	2019	In addition, sublethal treatment with PAM induced phosphorylation of ATM kinase, accumulation of p53 protein, and expression of p21 and GADD45A, which are known p53 target genes, in a Zn2+-dependent manner.	Zinc	184-188	tumor protein p53	Homo sapiens	161-164
31379409-9	2019	These results suggest that the induction of growth arrest and cellular senescence by sublethal PAM treatment is mediated by Zn2+-dependent activation of the ATM/p53 pathway.	Zinc	124-128	tumor protein p53	Homo sapiens	161-164
31115566-11	2019	Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO-1 expression compared with the HG group.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	44-48
31115566-11	2019	Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO-1 expression compared with the HG group.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-120
31115566-11	2019	Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO-1 expression compared with the HG group.	Zinc	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-120
31115566-11	2019	Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO-1 expression compared with the HG group.	Zinc	150-152	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	187-191
31115566-12	2019	In conclusion, Zn supplementation was proposed to suppress the effects of HG on the EMT by stimulating the Nrf2 antioxidant pathway and subsequently reducing oxidative stress in PMCs.	Zinc	15-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
30952310-3	2019	Under optimized conditions (1.25 mL of 5 mg L-1 MIP-PEG-ZnS QDs solution, pH 5.0, and 12 min delay time before scanning), the prepared MIP-QDs composite was found to offer high affinity and selectivity for AFs (AFB1, AFB2, AFG1 and AFG2).	Zinc	56-59	spermatogenesis associated 5	Homo sapiens	232-236
31111849-9	2019	Experiments performed with a mixture of four metal ions, Hg2+, Cd2+, Zn2+ and Ni2+, indicate that this molecular probe may potentially be used in Hg2+-sensing systems under acidic conditions for the measurement of muM range concentrations.	Zinc	69-73	latexin	Homo sapiens	214-217
31460144-7	2019	The adsorbents exhibited high selectivity in the Pb(II), Cu(II), and Zn(II) mixed solution, and the selectivity coefficient k of adsorbents to Pb(II) could reach approximately 2.74 in triad.	Zinc	69-75	submaxillary gland androgen regulated protein 3B	Homo sapiens	143-149
31588339-8	2019	However, ZnO NPs significantly promoted the ratio of caspase-3/pro-caspase-3, which was inhibited by the presence of MY.	Zinc	9-12	caspase 3	Homo sapiens	53-62
31588339-8	2019	However, ZnO NPs significantly promoted the ratio of caspase-3/pro-caspase-3, which was inhibited by the presence of MY.	Zinc	9-12	caspase 3	Homo sapiens	63-76
30738010-9	2019	Zn2+ had a direct effect on GIP secretion from pGIPneo STC-1 cells, increasing GIP secretion by 1.3-fold.	Zinc	0-4	gastric inhibitory polypeptide	Mus musculus	28-31
30738010-9	2019	Zn2+ had a direct effect on GIP secretion from pGIPneo STC-1 cells, increasing GIP secretion by 1.3-fold.	Zinc	0-4	gastric inhibitory polypeptide	Mus musculus	48-51
30738010-10	2019	GPR39 is expressed on intestinal L- and K-cells, and stimulated GIP secretion plays an integral role in mediating enhanced insulin secretion and glucose tolerance following oral administration of Zn2+.	Zinc	196-200	gastric inhibitory polypeptide	Mus musculus	64-67
31316722-8	2019	Our results revealed that Ni2+ treatment significantly primed the Zn2+-induced ER stress response, especially expression of the CCAAT-enhancer-binding protein homologous protein (CHOP).	Zinc	66-70	DNA damage inducible transcript 3	Homo sapiens	128-177
31312368-6	2019	Furthermore, excessive Zn2+ supplementation activated the GSK3/mTOR signaling pathway in both SW620 and LoVo cells, and excessive Zn2+ supplementation promoted migration, invasion, and EMT of SW620 and LoVo cells.	Zinc	23-27	mechanistic target of rapamycin kinase	Homo sapiens	63-67
31312368-10	2019	In conclusion, excessive Zn2+ promotes migration and invasion capabilities of SW620 and LoVo cells through GSK3/mTOR signaling pathway-induced EMT.	Zinc	25-29	mechanistic target of rapamycin kinase	Homo sapiens	112-116
31316722-8	2019	Our results revealed that Ni2+ treatment significantly primed the Zn2+-induced ER stress response, especially expression of the CCAAT-enhancer-binding protein homologous protein (CHOP).	Zinc	66-70	DNA damage inducible transcript 3	Homo sapiens	179-183
31190146-8	2019	However, the results indicate increasing BAF values with decreasing soil element levels, especially for Cd, Pb and Zn, indicating limited uptake of elements by the organisms living in contact with extremely contaminated soil.	Zinc	115-117	BAF nuclear assembly factor 1	Homo sapiens	41-44
30880051-3	2019	HSA loading with Zn2+ decreases nmax value by 0.3-1.5, while its saturation with Cu2+ causes the FA-dependent nmax changes by up to 0.9.	Zinc	17-21	albumin	Homo sapiens	0-3
30880051-6	2019	The surface hydrophobicity of HSA is Cu2+-, Zn2+-, and FA-dependent and decreases upon the FA binding, according to bis-ANS fluorescence data.	Zinc	44-48	albumin	Homo sapiens	30-33
30880051-7	2019	Overall, Zn2+ or Cu2+ binding selectively affect HSA interaction with the FAs studied, in part due to changes in quaternary structure of the protein.	Zinc	9-13	albumin	Homo sapiens	49-52
30880051-1	2019	Human serum albumin (HSA) serves as a depot and carrier of multiple unrelated ligands including several participants of the pathogenesis of Alzheimer"s disease (AD), such as amyloid beta peptide (Abeta), Zn2+/Cu2+ ions, docosahexaenoic (DHA), linoleic (LA), and oleic (OA) acids.	Zinc	204-208	albumin	Homo sapiens	6-25
30444646-6	2019	Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8.	Zinc	18-22	solute carrier family 30 member 7	Rattus norvegicus	234-238
31171812-5	2019	Platelets isolated from Unc13d-/- mice, characterized by combined defects of alpha/delta granular release, showed a markedly impaired Zn2+ release upon activation.	Zinc	134-138	unc-13 homolog D	Mus musculus	24-30
31171812-8	2019	In turbidity and flow based assays, platelet-dependent fibrin formation was impaired in both Nbeal2-/- and Unc13d-/- mice, and the impairment could be partially restored by extracellular Zn2+.	Zinc	187-191	unc-13 homolog D	Mus musculus	107-113
31263692-9	2019	In addition, the effect on the ability of Ydj1 to protect a model protein (luciferase) against aggregation was completely abolished after the Zn removal procedure.	Zinc	142-144	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	42-46
31042246-1	2019	We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-beta [Zn(ii)-Abeta], two pathological targets found in the brain affected by Alzheimer"s disease.	Zinc	138-144	amyloid beta precursor protein	Homo sapiens	172-177
31042246-2	2019	Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Abeta (phen, 1, and 2), or both (3).	Zinc	42-48	sphingomyelin phosphodiesterase 1	Homo sapiens	168-171
30851144-4	2019	The high microporosity of PIM-1 promoted a high Zn2+ loading rate.	Zinc	48-52	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	26-31
30851144-5	2019	Additionally, the relatively stable ionic bond formed between Zn2+ and the PIM-1 framework through electrostatic interaction ensured high loading stability.	Zinc	62-66	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	75-80
30091069-6	2019	The serum Zn and Cu levels of the diabetic subjects were negatively correlated with the serum glucose, the serum Zn and Cu/Zn ratio was inversely correlated with the serum total cholesterol and the serum insulin level was positively associated with the hair Cu/Zn ratio.	Zinc	10-12	insulin	Homo sapiens	204-211
31042246-2	2019	Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Abeta (phen, 1, and 2), or both (3).	Zinc	42-48	amyloid beta precursor protein	Homo sapiens	190-195
30833508-0	2019	Intracellular Zn2+ Signaling Facilitates Mossy Fiber Input-Induced Heterosynaptic Potentiation of Direct Cortical Inputs in Hippocampal CA3 Pyramidal Cells.	Zinc	14-18	carbonic anhydrase 3	Homo sapiens	136-139
30833508-9	2019	We show here that Zn2+ released from hippocampal mossy fiber (MF) terminals enters postsynaptic CA3 pyramidal cells, and plays a facilitating role in MF input-induced heterosynaptic potentiation of perforant path (PP) synaptic inputs through long-term potentiation of intrinsic excitability (LTP-IE).	Zinc	18-22	carbonic anhydrase 3	Homo sapiens	96-99
30744926-4	2019	The suppression threshold of Zn(II) on denitrifying bacteria was 10 mg L-1 for long-term exposure.	Zinc	29-35	L1 cell adhesion molecule	Homo sapiens	71-74
30744926-5	2019	The nitrogen removal rate was decreased by long-term addition of 10 mg L-1 Zn(II).	Zinc	75-81	L1 cell adhesion molecule	Homo sapiens	71-74
30746812-6	2019	Zn 2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-AC-cAMP-PKA-Src-EGFR and phospholipase C. Both the transmembrane adenylyl cyclase (AC) and the soluble-AC are involved in the stimulation of HAM by Zn 2+ .	Zinc	0-5	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	109-112
30690405-5	2019	Secondly, Zn pre-exposure reduced Cd accumulation at 100 and 200 mug/L Cd, down-regulated il-6 and il-1beta at 100 mug/L Cd and p65 at 200 mug/L Cd, and increased Cu/Zn-SOD and CAT activities at 200 mug/L Cd.	Zinc	10-12	interleukin 1, beta	Danio rerio	99-107
30690405-5	2019	Secondly, Zn pre-exposure reduced Cd accumulation at 100 and 200 mug/L Cd, down-regulated il-6 and il-1beta at 100 mug/L Cd and p65 at 200 mug/L Cd, and increased Cu/Zn-SOD and CAT activities at 200 mug/L Cd.	Zinc	10-12	superoxide dismutase 1, soluble	Danio rerio	163-172
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	heat shock transcription factor 2	Danio rerio	73-77
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	superoxide dismutase 1, soluble	Danio rerio	124-128
30801843-6	2019	Additionally, Zn-POS supplementation increased gene expressions of metallothionein, Zn transporter 1, Zn transporter 2 in the pancreas, nuclear factor erythroid 2-related factor 2 in the liver, the concentrations of acetate, propionate, butyrate and total SCFA in the caecal digesta and the villus height to crypt depth ratio in the duodenum and jejunum, whereas decreased the crypt depth in these two tissues.	Zinc	14-16	NFE2 like bZIP transcription factor 2	Homo sapiens	136-179
30746812-6	2019	Zn 2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-AC-cAMP-PKA-Src-EGFR and phospholipase C. Both the transmembrane adenylyl cyclase (AC) and the soluble-AC are involved in the stimulation of HAM by Zn 2+ .	Zinc	0-5	epidermal growth factor receptor	Homo sapiens	113-117
30714183-14	2019	Combined Zn and PTX inhibited prostate cancer cell invasion and migration by downregulating the expression of TWIST1.	Zinc	9-11	twist family bHLH transcription factor 1	Homo sapiens	110-116
30714183-17	2019	CONCLUSIONS: Our results demonstrated that Zn and PTX combined therapy inhibits EMT by reducing the expression of TWIST1, which reduces the invasion and migration of prostate cancer cells.	Zinc	43-45	twist family bHLH transcription factor 1	Homo sapiens	114-120
31052346-4	2019	Here we apply a multi-disciplinary approach using small angle X-ray scattering, nuclear magnetic resonance spectroscopy, calorimetry and computations to show that that saliva protein Histatin 5 forms highly dynamic oligomers in the presence of Zn2+.	Zinc	244-248	histatin 3	Homo sapiens	183-193
30957488-3	2019	Here, we demonstrate that Ca2+ binding to S100A12"s EF-hand motifs and Zn2+ binding to its dimeric interface cooperate to induce reversible self-assembly of the protein.	Zinc	71-75	S100 calcium binding protein A12	Homo sapiens	42-49
30957488-4	2019	Solution and magic angle spinning nuclear magnetic resonance spectroscopy on apo-, Ca2+-, Zn2+-, and Ca2+,Zn2+-S100A12 shows that significant metal binding-induced chemical shift perturbations, indicative of conformational changes, occur throughout the polypeptide chain.	Zinc	90-94	S100 calcium binding protein A12	Homo sapiens	111-118
31052346-7	2019	Finally, as Histatin 5 is an important saliva component, we suggest that Zn2+ induced oligomerisation may be crucial for maintaining saliva homeostasis.	Zinc	73-77	histatin 3	Homo sapiens	12-22
30957488-4	2019	Solution and magic angle spinning nuclear magnetic resonance spectroscopy on apo-, Ca2+-, Zn2+-, and Ca2+,Zn2+-S100A12 shows that significant metal binding-induced chemical shift perturbations, indicative of conformational changes, occur throughout the polypeptide chain.	Zinc	106-110	S100 calcium binding protein A12	Homo sapiens	111-118
30957488-6	2019	While the overall structure of S100A12 is dominated by Ca2+ binding, Zn2+ binding to Ca2+-S100A12 introduces additional structural changes to helix II and the hinge domain (residues 38-53).	Zinc	69-73	S100 calcium binding protein A12	Homo sapiens	90-97
30830753-0	2019	Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.	Zinc	61-64	phospholipase A2 group XV	Homo sapiens	20-46
30957488-9	2019	We discuss how the additional conformational changes introduced to these domains upon Zn2+ binding may also impact the interaction of S100A12 and target proteins such as RAGE.	Zinc	86-90	S100 calcium binding protein A12	Homo sapiens	134-141
30851936-5	2019	Loss of zip6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels.	Zinc	105-107	solute carrier family 39 member 6	Danio rerio	8-12
30851936-7	2019	Our results suggest that ZIP6 plays a critical part in T cell development, and enhance our understanding of Zn homeostasis and immune system maintenance.	Zinc	108-110	solute carrier family 39 member 6	Homo sapiens	25-29
30890462-7	2019	Moreover, Zn2+ ions and osteostatin together, but not independently, in the scaffolds were found to induce the osteoblast differentiation genes runt related transcription factor-2 (RUNX2) and alkaline phosphatase (ALP) in hMSCs after 7 d of culture in the absence of an osteogenic differentiation-promoting medium.	Zinc	10-14	RUNX family transcription factor 2	Homo sapiens	144-179
30890462-7	2019	Moreover, Zn2+ ions and osteostatin together, but not independently, in the scaffolds were found to induce the osteoblast differentiation genes runt related transcription factor-2 (RUNX2) and alkaline phosphatase (ALP) in hMSCs after 7 d of culture in the absence of an osteogenic differentiation-promoting medium.	Zinc	10-14	RUNX family transcription factor 2	Homo sapiens	181-186
30890462-7	2019	Moreover, Zn2+ ions and osteostatin together, but not independently, in the scaffolds were found to induce the osteoblast differentiation genes runt related transcription factor-2 (RUNX2) and alkaline phosphatase (ALP) in hMSCs after 7 d of culture in the absence of an osteogenic differentiation-promoting medium.	Zinc	10-14	alkaline phosphatase, placental	Homo sapiens	192-212
30890462-7	2019	Moreover, Zn2+ ions and osteostatin together, but not independently, in the scaffolds were found to induce the osteoblast differentiation genes runt related transcription factor-2 (RUNX2) and alkaline phosphatase (ALP) in hMSCs after 7 d of culture in the absence of an osteogenic differentiation-promoting medium.	Zinc	10-14	alkaline phosphatase, placental	Homo sapiens	214-217
30597373-6	2019	Adsorption experiments revealed that Zn/Fe-LDH composite sponge exhibited a much higher adsorption ability for As(V) anions and methyl orange (MO) compared with a Zn/Fe-LDH powder or the pristine PVA sponge.	Zinc	37-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	111-116
30830753-2	2019	Divalent cations such as Ca2+ and Mg2+ have previously been shown to have little effect on the activity of LPLA2, but the discovery of a novel crystal form of LPLA2 with Zn2+ bound in the active site suggested a role for this divalent cation in regulating enzyme activity.	Zinc	170-174	phospholipase A2 group XV	Homo sapiens	159-164
30830753-5	2019	Therefore, we hypothesized that Zn2+ would inhibit LPLA2 activity at a neutral but not acidic pH because histidine would be positively charged at lower pH.	Zinc	32-36	phospholipase A2 group XV	Homo sapiens	51-56
30830753-6	2019	Indeed, Zn2+ was found to inhibit the esterase activity of LPLA2 in a noncompetitive manner exclusively at a neutral pH (between 6.5 and 8.0).	Zinc	8-12	phospholipase A2 group XV	Homo sapiens	59-64
30830753-7	2019	Because lysosomes are reservoirs of Zn2+ in cells, the pH optimum of LPLA2 might allow it to catalyze acyl transfer unimpeded within the organelle.	Zinc	36-40	phospholipase A2 group XV	Homo sapiens	69-74
29742958-7	2019	Recent studies provide evidence of differences in sources of Zn2+ and its interactions with mitochondria in CA1 versus CA3 neurons that may pertain to their differential vulnerabilities in disease.	Zinc	61-65	carbonic anhydrase 3	Homo sapiens	119-122
30830753-8	2019	We conjecture that Zn2+ inhibition of LPLA2 at higher pH maintains a lower activity of the esterase in environments where its activity is not typically required.	Zinc	19-23	phospholipase A2 group XV	Homo sapiens	38-43
30823346-7	2019	Fifty percent of the genes differentially expressed in the ZnSO4 treatment, including the three metal responsive genes (mtl-1, mtl-2 and numr-1), were shared among all treatments, suggesting that responses to all forms of Zn could be partially attributed to dissolved Zn.	Zinc	59-61	Metallothionein-1	Caenorhabditis elegans	120-125
30823346-7	2019	Fifty percent of the genes differentially expressed in the ZnSO4 treatment, including the three metal responsive genes (mtl-1, mtl-2 and numr-1), were shared among all treatments, suggesting that responses to all forms of Zn could be partially attributed to dissolved Zn.	Zinc	222-224	Metallothionein-1	Caenorhabditis elegans	120-125
30783936-8	2019	The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p &lt; 0.01).	Zinc	27-29	interleukin 6	Homo sapiens	101-105
30783936-8	2019	The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p &lt; 0.01).	Zinc	27-29	tumor necrosis factor	Homo sapiens	117-126
30720917-6	2019	Also, the compound could inhibit beta-secretase 1 (BACE1) with IC50 =19.60 mum and showed metal chelating ability toward Cu2+ , Fe2+ , and Zn2+ .	Zinc	139-143	beta-secretase 1	Homo sapiens	33-49
30720917-6	2019	Also, the compound could inhibit beta-secretase 1 (BACE1) with IC50 =19.60 mum and showed metal chelating ability toward Cu2+ , Fe2+ , and Zn2+ .	Zinc	139-143	beta-secretase 1	Homo sapiens	51-56
30884854-0	2019	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	Zinc	16-18	tripartite motif containing 32	Homo sapiens	38-44
30675888-11	2019	The responsiveness of ZnT1 in odontoblasts to zinc availability is concordant with this being a process that is regulated to maintain cellular Zn homeostasis and that is a mediator of the relationship between environmental Zn exposure and dental Zn deposition.	Zinc	143-145	solute carrier family 30 member 1	Homo sapiens	22-26
30675888-11	2019	The responsiveness of ZnT1 in odontoblasts to zinc availability is concordant with this being a process that is regulated to maintain cellular Zn homeostasis and that is a mediator of the relationship between environmental Zn exposure and dental Zn deposition.	Zinc	143-145	solute carrier family 30 member 1	Homo sapiens	22-26
30786955-7	2019	Together, the results indicate that the Hps1 and Ap3b1 genes play distinct roles in male reproductive system development and spermatogenesis in mice, even though ep and pe males share common phenotypes, including reduced lysosomes in Sertoli cells and dislocated Zn2+ in sperm heads.	Zinc	263-267	adaptor-related protein complex 3, beta 1 subunit	Mus musculus	49-54
30843389-0	2019	Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-beta Oligomers and for the Early Diagnosis of Alzheimer"s Disease.	Zinc	23-25	amyloid beta precursor protein	Homo sapiens	106-118
30884854-4	2019	In this study, we adopted an in vitro approach using recombinant point- and deletion-mutants to characterize the contribution of the TRIM32 Zn-binding domains to the activity of this E3 ligase that is altered in a genetic form of muscular dystrophy.	Zinc	140-142	tripartite motif containing 32	Homo sapiens	133-139
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30806793-1	2019	The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on addition of glutathione (GSH) but is strongly enhanced in the presence of Zn(II) even in concentrations as low as 10 muM.	Zinc	20-23	latexin	Homo sapiens	207-210
30941358-16	2019	In 7 patients that completed the treatment period, there was an association between elevated serum levels of IL-6, IL-1beta, TNF-alpha, CRP, and LPL and also the reduced serum levels of albumin, prealbumin, Zn, vitamin D, and GPS, respectively.	Zinc	207-209	interleukin 6	Homo sapiens	109-113
30770447-6	2019	The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn2+ and Mg2+ Consistently, we found that endogenous TRPM7 regulates the total content of Zn2+ and Mg2+ in cultured cells.	Zinc	86-90	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	4-9
30770447-6	2019	The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn2+ and Mg2+ Consistently, we found that endogenous TRPM7 regulates the total content of Zn2+ and Mg2+ in cultured cells.	Zinc	86-90	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	139-144
30770447-6	2019	The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn2+ and Mg2+ Consistently, we found that endogenous TRPM7 regulates the total content of Zn2+ and Mg2+ in cultured cells.	Zinc	176-180	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	4-9
30770447-6	2019	The TRPM7 channel reconstituted in lipid bilayers displayed a similar permeability to Zn2+ and Mg2+ Consistently, we found that endogenous TRPM7 regulates the total content of Zn2+ and Mg2+ in cultured cells.	Zinc	176-180	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	139-144
30770447-7	2019	Unexpectedly, genetic inactivation of intestinal rather than kidney TRPM7 caused profound deficiencies specifically of Zn2+, Mg2+, and Ca2+ at the organismal level, a scenario incompatible with early postnatal growth and survival.	Zinc	119-123	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	68-73
30770447-9	2019	Finally, dietary Zn2+ and Mg2+ fortifications significantly extended the survival of offspring lacking intestinal TRPM7.	Zinc	17-21	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	114-119
30806793-1	2019	The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on addition of glutathione (GSH) but is strongly enhanced in the presence of Zn(II) even in concentrations as low as 10 muM.	Zinc	164-170	latexin	Homo sapiens	207-210
30424909-7	2019	Exposed to high concentration of Zn, AQUA1 also co-localized with AtTIP1;1, a well-known Arabidopsis vacuolar marker, probably in pro-vacuolar multivesicular bodies.	Zinc	33-35	gamma tonoplast intrinsic protein	Arabidopsis thaliana	66-74
30543238-2	2019	However, mouse MT2, in contrast to MT1, exhibits a preference for Zn(ii) coordination in comparison to that for Cu(i), which might underlie putatively different biological functions for these two mammalian isoforms.	Zinc	66-72	metallothionein 2	Mus musculus	15-18
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	100-102	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	45-48
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	100-102	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	63-66
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	100-102	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	63-66
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	141-143	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	45-48
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	141-143	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	63-66
30439421-3	2019	Maillard reaction occurred between l-Phe and OSt to form l-Phe-OSt, which was then coordinated with Zn (II) by carboxyl groups for l-Phe-OSt Zn (II).	Zinc	141-143	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	63-66
30723194-2	2019	Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone ERp44, modulating its localization and ability to retrieve clients like Ero1alpha and ERAP1 to the endoplasmic reticulum (ER).	Zinc	19-23	endoplasmic reticulum protein 44	Homo sapiens	79-84
30723194-3	2019	Silencing the Zn2+ transporters that uptake Zn2+ into the Golgi led to ERp44 dysfunction and increased secretion of Ero1alpha and ERAP1.	Zinc	14-18	endoplasmic reticulum protein 44	Homo sapiens	71-76
30723194-4	2019	High-resolution crystal structures of Zn2+-bound ERp44 reveal that Zn2+ binds to a conserved histidine-cluster.	Zinc	38-42	endoplasmic reticulum protein 44	Homo sapiens	49-54
30723194-4	2019	High-resolution crystal structures of Zn2+-bound ERp44 reveal that Zn2+ binds to a conserved histidine-cluster.	Zinc	67-71	endoplasmic reticulum protein 44	Homo sapiens	49-54
30723194-6	2019	ERp44 also forms Zn2+-bridged homodimers, which dissociate upon client binding.	Zinc	17-21	endoplasmic reticulum protein 44	Homo sapiens	0-5
30723194-7	2019	Histidine mutations in the Zn2+-binding sites compromise ERp44 activity and localization.	Zinc	27-31	endoplasmic reticulum protein 44	Homo sapiens	57-62
30593499-5	2019	We found that unlike mammalian Cu,Zn-SOD1, C. albicans SOD5 indeed rapidly loses its copper to metal chelators such as EDTA, and binding constants for Cu(II) predict that copper-only SOD5 has a much lower affinity for copper than does Cu,Zn-SOD1.	Zinc	34-36	superoxide dismutase 1	Homo sapiens	37-41
30366240-2	2019	In February and March, Mn oxides reduction caused high concentrations of DGT-labile Zn (14 ~ 235 mug L-1), as evidenced by the significant correlation between DGT-labile Zn and DGT-labile Mn in sediments.	Zinc	84-86	immunoglobulin kappa variable 1-16	Homo sapiens	101-104
30366240-4	2019	From August through October, concentrations of dissolved Zn in overlying water (338 ~ 1023 mug L-1) exceeded the water quality limit for fisheries in China (100 mug L-1).	Zinc	57-59	immunoglobulin kappa variable 1-16	Homo sapiens	95-98
30366240-4	2019	From August through October, concentrations of dissolved Zn in overlying water (338 ~ 1023 mug L-1) exceeded the water quality limit for fisheries in China (100 mug L-1).	Zinc	57-59	immunoglobulin kappa variable 1-16	Homo sapiens	165-168
30406698-7	2019	Zn2+ prevents elevation of IL-6 and IL-8.	Zinc	0-4	interleukin 6	Mus musculus	27-31
29098957-5	2019	For the best adsorbent, adsorption capacities followed the order Cu(II) &gt; Pb(II) &gt; Zn(II) &gt; Cr(III) &gt; Cd(II) &gt; Ni(II).	Zinc	89-91	submaxillary gland androgen regulated protein 3B	Homo sapiens	77-83
31544812-3	2019	After washing the beads, the binding of biotinylated PPIX with IgG trapped on Zn-beads was detected using alkaline phosphatase (ALP)-labeled avidin.	Zinc	78-80	alkaline phosphatase, placental	Homo sapiens	106-126
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	superoxide dismutase 1, soluble	Danio rerio	103-107
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	interleukin 1, beta	Danio rerio	138-146
30234208-0	2019	Cu and Zn interactions with Abeta peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Abeta oligomers.	Zinc	7-9	amyloid beta precursor protein	Homo sapiens	28-33
30234208-0	2019	Cu and Zn interactions with Abeta peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Abeta oligomers.	Zinc	7-9	amyloid beta precursor protein	Homo sapiens	123-128
30234208-1	2019	The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-beta (Abeta) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer"s disease (AD).	Zinc	61-63	amyloid beta precursor protein	Homo sapiens	74-86
30234208-1	2019	The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-beta (Abeta) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer"s disease (AD).	Zinc	61-63	amyloid beta precursor protein	Homo sapiens	88-93
30234208-5	2019	A large number of reports indicate that transition metal ions such as Cu and Zn have significant effects on Abeta peptide aggregation and stabilization of neurotoxic soluble Abeta aggregates; some of these reports are contradictory too.	Zinc	77-79	amyloid beta precursor protein	Homo sapiens	108-113
30234208-6	2019	A review on the effects of Cu and Zn metal ions on Abeta peptide aggregation due to their coordination with these peptides is presented herein.	Zinc	34-36	amyloid beta precursor protein	Homo sapiens	51-56
30234208-7	2019	The review includes brief discussions with regards to the levels of Cu and Zn in an AD affected brain, structures of Abeta peptides, and the coordination of Abeta peptides with Cu and Zn.	Zinc	184-186	amyloid beta precursor protein	Homo sapiens	157-162
30234208-8	2019	In the current scenario, a consensus appears to be emerging regarding the coordination mode and the effect of metal ions (especially Cu and Zn) on the aggregation of Abeta peptides.	Zinc	140-142	amyloid beta precursor protein	Homo sapiens	166-171
30255176-1	2019	Mutations in the copper (Cu)- and zinc (Zn)-binding metalloenzyme Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal adult-onset neurodegenerative disorder of the central nervous system (CNS).	Zinc	40-42	superoxide dismutase 1, soluble	Mus musculus	94-98
30255176-9	2019	Also in contrast to adult mice, Zn redistribution to the CNS in response to SOD1 over-expression is relatively modest in embryonic mice, being limited to the brainstem.	Zinc	32-34	superoxide dismutase 1, soluble	Mus musculus	76-80
30687374-9	2018	Moreover, the present study provides new insights into the coordinated function of NtZIP1, NtZIP2, NtZIP4, NtZIP5, NtZIP8, NtIRT1, and NtIRT1-like in response to low-to-high Zn status.	Zinc	174-176	zinc transporter 5-like	Nicotiana tabacum	83-89
30501186-4	2019	The molecular modulator is able to selectively target Abeta species and block Zn2+ due to the specific recognition capability of aptamers.	Zinc	78-82	amyloid beta precursor protein	Homo sapiens	54-59
30501186-6	2019	More importantly, this molecular modulator can inhibit the generation of Zn2+-triggered Abeta aggregates due to the trapping of Zn2+ around Abeta species.	Zinc	73-77	amyloid beta precursor protein	Homo sapiens	88-93
30501186-6	2019	More importantly, this molecular modulator can inhibit the generation of Zn2+-triggered Abeta aggregates due to the trapping of Zn2+ around Abeta species.	Zinc	73-77	amyloid beta precursor protein	Homo sapiens	140-145
30501186-6	2019	More importantly, this molecular modulator can inhibit the generation of Zn2+-triggered Abeta aggregates due to the trapping of Zn2+ around Abeta species.	Zinc	128-132	amyloid beta precursor protein	Homo sapiens	88-93
30501186-6	2019	More importantly, this molecular modulator can inhibit the generation of Zn2+-triggered Abeta aggregates due to the trapping of Zn2+ around Abeta species.	Zinc	128-132	amyloid beta precursor protein	Homo sapiens	140-145
31257282-0	2019	Age-Dependent Modification of Intracellular Zn2+ Buffering in the Hippocampus and Its Impact.	Zinc	44-48	renin binding protein	Homo sapiens	0-3
31257282-3	2019	It is estimated that the age-dependent increase in the basal concentration of extracellular Zn2+ in the hippocampus plays a key role in cognitive decline and neurodegeneration.	Zinc	92-96	renin binding protein	Homo sapiens	25-28
31257282-4	2019	The characteristics of extracellular Zn2+ influx in the hippocampus may be modified age-dependently, probably followed by modification of intracellular Zn2+ buffering that is closely linked with age-related cognitive decline and neurodegeneration.	Zinc	37-41	renin binding protein	Homo sapiens	84-87
31257282-4	2019	The characteristics of extracellular Zn2+ influx in the hippocampus may be modified age-dependently, probably followed by modification of intracellular Zn2+ buffering that is closely linked with age-related cognitive decline and neurodegeneration.	Zinc	152-156	renin binding protein	Homo sapiens	195-198
31257282-6	2019	This paper deals with age-dependent modification of intracellular Zn2+ buffering in the hippocampus and its impact.	Zinc	66-70	renin binding protein	Homo sapiens	22-25
29999409-5	2019	Zn ions are required for the dimerization of endothelial nitric oxide synthase and subsequent generation of NO while generation of NO leads to a rapid mobilization of endothelial Zn stores.	Zinc	0-2	nitric oxide synthase 3	Homo sapiens	45-78
29299811-3	2019	The mutant overexpressed SOD1G93A protein does not properly bind zinc (Zn) in animal models; hence, mutant SOD1G93A-Cn interaction weakens.	Zinc	71-73	superoxide dismutase 1	Homo sapiens	25-29
30710280-1	2019	S100 proteins are distinct dimeric EF-hand Ca2+-binding proteins that can bind Zn2+, Mn2+, and other transition metals with high affinity at two sites in the dimer interface.	Zinc	79-83	S100 calcium binding protein B	Homo sapiens	0-4
29299811-7	2019	This study further supports our previously published work indicating that Cn stability depends on functional Cn-SOD1 interaction because Zn is crucial for maintaining the Cn stability.	Zinc	137-139	superoxide dismutase 1	Homo sapiens	112-116
30774894-5	2019	Our probe, A-1, is composed of Abeta1-21 grafted with a pair of FRET donor and acceptor capable of providing a FRET signal upon Zn(ii) binding even at nanomolar concentrations.	Zinc	128-134	BCL2 related protein A1	Homo sapiens	11-14
30643476-1	2019	Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress.	Zinc	36-38	superoxide dismutase 1	Homo sapiens	102-122
30643476-1	2019	Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress.	Zinc	36-38	superoxide dismutase 1	Homo sapiens	124-127
30495946-3	2018	The unique feature of this new radical germylzincation reaction is that the C(sp2)-Zn bond formed remains available for subsequent in situ Cu(I)- or Pd(0)-mediated C-C or C-heteroatom bond formation with retention of the double bond geometry.	Zinc	83-85	Sp2 transcription factor	Homo sapiens	76-81
30184139-10	2019	Moreover, dietary supplementation with 40 or 80 mg/kg organic Zn increased the MT mRNA expression of the liver at week 72, whereas 20 mg/kg of organic Zn decreased it (P &lt; 0.05).	Zinc	62-64	metallothionein 4	Gallus gallus	79-81
30184139-11	2019	In conclusion, this study suggested that an optimum dietary (40 mg/kg) organic Zn level plays a key role in promoting the apparent retention of minerals and nutrients, trace element deposit, and MT mRNA expression.	Zinc	79-81	metallothionein 4	Gallus gallus	195-197
30371694-3	2018	The phosphorescence of 3-mercaptopropionic acid capped Mn-doped ZnS quantum dots (MPA-Mn:ZnS QDs) was gradually quenched with the addition of thrombin binding aptamers-BHQ2 (TBA-BHQ2) based on phosphorescence resonance energy transfer (PRET).	Zinc	64-67	coagulation factor II, thrombin	Homo sapiens	142-150
30371694-3	2018	The phosphorescence of 3-mercaptopropionic acid capped Mn-doped ZnS quantum dots (MPA-Mn:ZnS QDs) was gradually quenched with the addition of thrombin binding aptamers-BHQ2 (TBA-BHQ2) based on phosphorescence resonance energy transfer (PRET).	Zinc	89-92	coagulation factor II, thrombin	Homo sapiens	142-150
30774894-6	2019	The FRET intensity of A-1 increases upon Zn(ii) binding and decreases when Zn(ii)-bound A-1 aggregates.	Zinc	41-47	BCL2 related protein A1	Homo sapiens	22-25
30774894-6	2019	The FRET intensity of A-1 increases upon Zn(ii) binding and decreases when Zn(ii)-bound A-1 aggregates.	Zinc	75-81	BCL2 related protein A1	Homo sapiens	22-25
30774894-6	2019	The FRET intensity of A-1 increases upon Zn(ii) binding and decreases when Zn(ii)-bound A-1 aggregates.	Zinc	75-81	BCL2 related protein A1	Homo sapiens	88-91
30774894-7	2019	Moreover, as the FRET intensity of Zn(ii)-added A-1 is drastically changed when their interaction is disrupted, A-1 can be used for screening a chemical library to determine effective inhibitors against metal-Abeta interaction.	Zinc	35-41	BCL2 related protein A1	Homo sapiens	48-51
30774894-7	2019	Moreover, as the FRET intensity of Zn(ii)-added A-1 is drastically changed when their interaction is disrupted, A-1 can be used for screening a chemical library to determine effective inhibitors against metal-Abeta interaction.	Zinc	35-41	BCL2 related protein A1	Homo sapiens	112-115
28941826-11	2018	CONCLUSIONS: Prediabetic postmenopausal women are characterized by significantly lower levels of serum Zn concentration, whereas serum Zn and Sr levels were inversely associated with insulin resistance.	Zinc	135-137	insulin	Homo sapiens	183-190
30510262-5	2018	Employing crystallography, spectroscopy, and gas adsorption analysis, we demonstrate that CS2 is indeed cooperatively adsorbed in N,N-dimethylethylenediamine-appended M2(dobpdc) (M = Mg, Mn, Zn; dobpdc4- = 4,4"-dioxidobiphenyl-3,3"-dicarboxylate), via the formation of electrostatically paired ammonium dithiocarbamate chains.	Zinc	191-193	chorionic somatomammotropin hormone 2	Homo sapiens	90-93
30296647-10	2018	The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.	Zinc	48-50	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-149
30230059-2	2018	The common p53 mutation Y220C causes local protein unfolding, aggregation, and can result in a loss of Zn in the DNA-binding domain.	Zinc	103-105	tumor protein p53	Homo sapiens	11-14
30230059-5	2018	Their Zn-binding affinity was characterized using spectroscopic methods and demonstrate the ability of compounds L4 and L5 to increase intracellular levels of Zn2+ in a p53-Y220C-mutant cell line.	Zinc	159-163	tumor protein p53	Homo sapiens	169-172
29651733-5	2018	The interactions with phosphatases showed a concerted mechanism displayed by the Zn ions and ZnLos up to 500 muM concentration: a decrease of the acid phosphatase (AcP) associated with an increase in the alkaline phosphatase (ALP) activities.	Zinc	81-83	alkaline phosphatase, placental	Homo sapiens	204-224
29651733-5	2018	The interactions with phosphatases showed a concerted mechanism displayed by the Zn ions and ZnLos up to 500 muM concentration: a decrease of the acid phosphatase (AcP) associated with an increase in the alkaline phosphatase (ALP) activities.	Zinc	81-83	alkaline phosphatase, placental	Homo sapiens	226-229
28941826-8	2018	Serum Zn levels were characterized by a significant inverse correlation with HbA1c (r=- 0.205; p=0.009), insulin (r=- 0.246; p=0.002), and HOMA-IR (r=- 0.227; p=0.004).	Zinc	6-8	insulin	Homo sapiens	105-112
30033906-7	2018	Biochemically, Fe and Zn in insects occur predominantly in non-haem forms, bound to the proteins ferritin, transferrin and other transport and storage proteins.	Zinc	22-24	transferrin	Homo sapiens	107-118
29619854-8	2018	Our results showed that the relative bioavailability of Tf-exenatide-Zn2+-NPs was higher than that of exenatide-Zn2+-NPs.	Zinc	69-73	transferrin	Homo sapiens	56-58
30568444-3	2018	Results: Only ZnO NPs significantly induced cytotoxicity, accompanied by increased intracellular reactive oxygen species, Zn ions, and endoplasmic reticulum stress biomarkers (DDIT3 expression and p-Chop proteins).	Zinc	14-16	DNA damage inducible transcript 3	Homo sapiens	176-181
30176255-6	2018	The evidence that AMPA-induced intracellular Zn2+ dysregulation causes movement disorder via nigrostriatal dopaminergic neurodegeneration suggests that AMPA receptors, probably Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors are potential targets for overcoming Parkinson"s syndrome.	Zinc	45-49	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	202-207
30176255-6	2018	The evidence that AMPA-induced intracellular Zn2+ dysregulation causes movement disorder via nigrostriatal dopaminergic neurodegeneration suggests that AMPA receptors, probably Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors are potential targets for overcoming Parkinson"s syndrome.	Zinc	187-191	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	202-207
30261176-5	2018	Previously, we suggested that release of free Zn2+ from damaged proteins represents an endogenous "danger" signal recognized by Keap1.	Zinc	46-50	kelch like ECH associated protein 1	Homo sapiens	128-133
30261176-6	2018	However, the existence of a Zn2+ sensor in Keap1 is not widely acknowledged.	Zinc	28-32	kelch like ECH associated protein 1	Homo sapiens	43-48
30261176-7	2018	We now present data that support the hypothesis that Keap1 directly senses Zn2+ through a cluster of amino-acids that include His-225, Cys-226, and Cys-613.	Zinc	75-79	kelch like ECH associated protein 1	Homo sapiens	53-58
30261176-9	2018	Moreover, using a genetically-encoded FRET reporter, we present evidence that binding of Zn2+ triggers a conformational switch in Keap1.	Zinc	89-93	kelch like ECH associated protein 1	Homo sapiens	130-135
30261176-11	2018	These data are consistent with the notion that Keap1 possesses a Zn2+ sensor whose triggering distorts its structure in a fashion that inhibits ubiquitylation of Nrf2 upon CRLKeap1.	Zinc	65-69	kelch like ECH associated protein 1	Homo sapiens	47-52
30261176-11	2018	These data are consistent with the notion that Keap1 possesses a Zn2+ sensor whose triggering distorts its structure in a fashion that inhibits ubiquitylation of Nrf2 upon CRLKeap1.	Zinc	65-69	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
30629543-7	2018	The influences of Cu(II), Cd(II), and Zn(II) on Pb(II) adsorption showed antagonistic effect strength in the order of Cu(II) &gt; Cd(II) &gt; Zn(II).	Zinc	38-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
30629543-7	2018	The influences of Cu(II), Cd(II), and Zn(II) on Pb(II) adsorption showed antagonistic effect strength in the order of Cu(II) &gt; Cd(II) &gt; Zn(II).	Zinc	142-148	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
30376013-3	2018	According to DFT studies, upon chelating a Zn2+ cation with two imidazole nitrogen atoms, receptor 1 adopts a conformation ideally fitted to recognise HSO4- through a combination of C(sp2)-HO and C(sp3)-HO hydrogen bondings, C+(sp2)-BrO halogen bonding and C(sp2)O tetrel bonding.	Zinc	43-47	Sp2 transcription factor	Homo sapiens	182-187
30524300-12	2018	Our molecular studies of NMDARs containing the GluN2A subunit showed that HP removal of the Zn2+ voltage-independent inhibition could be the mechanism explaining its current increase at HP.	Zinc	92-96	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	47-53
30376013-3	2018	According to DFT studies, upon chelating a Zn2+ cation with two imidazole nitrogen atoms, receptor 1 adopts a conformation ideally fitted to recognise HSO4- through a combination of C(sp2)-HO and C(sp3)-HO hydrogen bondings, C+(sp2)-BrO halogen bonding and C(sp2)O tetrel bonding.	Zinc	43-47	Sp2 transcription factor	Homo sapiens	257-262
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	130-132	Sp3 transcription factor	Homo sapiens	73-76
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	130-132	Sp2 transcription factor	Homo sapiens	78-81
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	130-132	Sp3 transcription factor	Homo sapiens	200-203
30255321-6	2018	Specifically, the device was used to investigate the binding affinity between Zn2+ and either normal human serum albumin (nHSA) or a commercially purchased glycated human serum albumin (gHSA).	Zinc	78-82	albumin	Homo sapiens	107-120
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	130-132	Sp3 transcription factor	Homo sapiens	200-203
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	187-189	Sp3 transcription factor	Homo sapiens	73-76
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	187-189	Sp2 transcription factor	Homo sapiens	78-81
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	187-189	Sp3 transcription factor	Homo sapiens	200-203
30204273-2	2018	The synthesis of the dimerization building block includes a Pd-catalyzed sp3 -sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3 -sp3 cross coupling of an alpha-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.	Zinc	187-189	Sp3 transcription factor	Homo sapiens	200-203
29525848-10	2018	When the ability of serum trace elements to modulate PON1 activity was explored, the analysis revealed a unique association with serum Zn.	Zinc	135-137	paraoxonase 1	Homo sapiens	53-57
29525848-11	2018	The current results strongly suggest that Zn may have a protective effect in non-coronary atherosclerosis and indicate that this element may exert its anti-inflammatory and antioxidant functions through interactions with PON1 activity.	Zinc	42-44	paraoxonase 1	Homo sapiens	221-225
30103140-7	2018	We found a &gt;30% reduction of kidney and liver Cd levels in Zn supplemented MT1-tg mice compared to non-supplemented controls, independently of the dose of Zn, without a significant reduction of Cu.	Zinc	62-64	metallothionein 1	Mus musculus	78-81
30103140-8	2018	Our data support the idea of a causal and inverse relationship between Zn intake and Cd content in organs of aged MT1-tg mice as suggested by observational studies in humans.	Zinc	71-73	metallothionein 1	Mus musculus	114-117
30086940-0	2018	Rapid aqueous synthesis of CuInS/ZnS quantum dots as sensor probe for alkaline phosphatase detection and targeted imaging in cancer cells.	Zinc	33-36	alkaline phosphatase, placental	Homo sapiens	70-90
30218331-3	2018	Results indicated that Zn was the most abundant metal with a concentration of 16.92 mug L-1 in fall and 19.91 mug L-1 in winter and flux of 4.71 mg m-2 in fall, while Cd was the least with a monthly mean concentration of 0.02-0.37 mug L-1.	Zinc	23-25	immunoglobulin kappa variable 1-16	Homo sapiens	88-91
30218331-3	2018	Results indicated that Zn was the most abundant metal with a concentration of 16.92 mug L-1 in fall and 19.91 mug L-1 in winter and flux of 4.71 mg m-2 in fall, while Cd was the least with a monthly mean concentration of 0.02-0.37 mug L-1.	Zinc	23-25	immunoglobulin kappa variable 1-16	Homo sapiens	114-117
30218331-3	2018	Results indicated that Zn was the most abundant metal with a concentration of 16.92 mug L-1 in fall and 19.91 mug L-1 in winter and flux of 4.71 mg m-2 in fall, while Cd was the least with a monthly mean concentration of 0.02-0.37 mug L-1.	Zinc	23-25	immunoglobulin kappa variable 1-16	Homo sapiens	114-117
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	76-78	charged multivesicular body protein 2B	Homo sapiens	229-233
31458095-5	2018	Binding of metals like Zn2+ or Cu2+ induces changes in the morphologies of these assemblies, making them fold, which inhibits their spontaneous interaction with Cytc.	Zinc	23-27	cytochrome c, somatic	Homo sapiens	161-165
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	128-130	charged multivesicular body protein 2B	Homo sapiens	229-233
30062837-2	2018	Here, it is shown that the use of protected pentaerythritol as a latent cross-linker and the use of a Zn(II) transesterification catalyst allows for the in situ dynamic network formation in PBT during processing, with a delayed onset of gelation.	Zinc	102-108	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	190-193
29902756-3	2018	The results indicated that the sensor L1 and L2 exhibited highly selective and sensitive recognition for Zn2+ ions.	Zinc	105-109	L1 cell adhesion molecule	Homo sapiens	38-47
29902756-6	2018	These results indicated that L1 and L2 can be applied as chemosensor for the detection of Zn2+ ion.	Zinc	90-94	L1 cell adhesion molecule	Homo sapiens	29-38
30024008-5	2018	DFT calculations of the relative interaction energies of inhibitors with Mg2+ and Zn2+ ions were performed on a model of the bimetal active site of PDE4.	Zinc	82-86	phosphodiesterase 4A	Homo sapiens	148-152
30114907-7	2018	The data reveal Zn effects on NRF2 antioxidant and NFkappaB signaling.	Zinc	16-18	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
30114907-7	2018	The data reveal Zn effects on NRF2 antioxidant and NFkappaB signaling.	Zinc	16-18	nuclear factor kappa B subunit 1	Homo sapiens	51-59
29726717-4	2018	Concomitant administration of metformin and Zn produced a significant decrease in serum levels of glucose and insulin and testicular levels of malondialdehyde and tumor necrosis factor alpha.	Zinc	44-46	tumor necrosis factor	Rattus norvegicus	163-190
29726717-6	2018	Moreover, co-administration of Zn and metformin significantly improved testicular histopathology, with a significant reduction in percent area of collagen fibers and nuclear factor kappa B (p65) immunoreactivity and a significant increase in seminiferous tubule diameter and connexin 43 immunoreactivity as compared with the diabetic and metformin-treated diabetic groups.	Zinc	31-33	synaptotagmin 1	Rattus norvegicus	190-193
29726717-6	2018	Moreover, co-administration of Zn and metformin significantly improved testicular histopathology, with a significant reduction in percent area of collagen fibers and nuclear factor kappa B (p65) immunoreactivity and a significant increase in seminiferous tubule diameter and connexin 43 immunoreactivity as compared with the diabetic and metformin-treated diabetic groups.	Zinc	31-33	gap junction protein, alpha 1	Rattus norvegicus	275-286
29427034-8	2018	These data demonstrate that in ovo Zn injection improved the embryonic development, and the organic Zn was more effective than inorganic Zn in enhancing DNA methylation and H3K9 acetylation in the liver MT4 promoter, but the precise mechanisms require further investigations.	Zinc	35-37	metallothionein 4	Gallus gallus	203-206
29427034-8	2018	These data demonstrate that in ovo Zn injection improved the embryonic development, and the organic Zn was more effective than inorganic Zn in enhancing DNA methylation and H3K9 acetylation in the liver MT4 promoter, but the precise mechanisms require further investigations.	Zinc	100-102	metallothionein 4	Gallus gallus	203-206
29427034-8	2018	These data demonstrate that in ovo Zn injection improved the embryonic development, and the organic Zn was more effective than inorganic Zn in enhancing DNA methylation and H3K9 acetylation in the liver MT4 promoter, but the precise mechanisms require further investigations.	Zinc	100-102	metallothionein 4	Gallus gallus	203-206
30142362-7	2018	CONCLUSIONS: Our data provide evidence of a substantial different Zn homeostasis regulation between Znt8 Arg-325 and Trp-325 carriers in PBMCs from T2DM patients.	Zinc	66-68	solute carrier family 30 member 10	Homo sapiens	100-104
29906492-12	2018	SOD and CAT were probably affected by the observed decreased amount of Cu, Zn, and Mn in liver of old animals.	Zinc	75-77	catalase	Rattus norvegicus	8-11
30031876-0	2018	Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.	Zinc	0-8	iron-sulfur cluster assembly enzyme	Homo sapiens	36-40
30031876-5	2018	Here, we show that recombinant human ISCU binds zinc(II) ion, as previously demonstrated with the E. coli orthologue IscU.	Zinc	48-56	iron-sulfur cluster assembly enzyme	Homo sapiens	37-41
30031876-5	2018	Here, we show that recombinant human ISCU binds zinc(II) ion, as previously demonstrated with the E. coli orthologue IscU.	Zinc	48-56	iron-sulfur cluster assembly enzyme	Homo sapiens	117-121
30031876-8	2018	Indeed, removal of zinc(II) ion from ISCU causes a moderate but significant increase in activity compared to SDA alone, and FXN can activate both zinc-depleted and zinc-bound forms of ISCU complexed to SDA.	Zinc	19-27	iron-sulfur cluster assembly enzyme	Homo sapiens	37-41
30031876-8	2018	Indeed, removal of zinc(II) ion from ISCU causes a moderate but significant increase in activity compared to SDA alone, and FXN can activate both zinc-depleted and zinc-bound forms of ISCU complexed to SDA.	Zinc	19-27	iron-sulfur cluster assembly enzyme	Homo sapiens	184-188
30150315-9	2018	We show that ZIP4 and ZIP9 respond to the local Zn status in both roots and shoots, in contrast to the systemic regulation identified here.	Zinc	48-50	solute carrier family 39 member 9	Homo sapiens	22-26
29783874-7	2018	However, ZnO NPs with or without pre-incubation of BSA resulted in comparable intracellular Zn ions, glutathione and reactive oxygen species in THP-1 macrophages.	Zinc	9-11	GLI family zinc finger 2	Homo sapiens	144-149
30213975-3	2018	Zn2+, Mn2+ and Fe2+ transform TTR into a protease able to cleave Abeta.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	65-70
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	39-43	DNA methyltransferase 3 alpha	Rattus norvegicus	201-207
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	39-43	methyl CpG binding protein 2	Rattus norvegicus	214-219
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	39-43	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	224-231
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	112-116	DNA methyltransferase 3 alpha	Rattus norvegicus	201-207
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	112-116	methyl CpG binding protein 2	Rattus norvegicus	214-219
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	112-116	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	224-231
29697006-6	2018	Exposure to both types of ZnO NPs was associated with cytotoxicity to THP-1 macrophages, which was equally mitigated by BSA or OA-BSA associated with decreased cellular Zn elements.	Zinc	26-28	GLI family zinc finger 2	Homo sapiens	70-75
30108148-3	2018	The channel domain comprises a nonselective cation channel with notable permeability to Mg2+ and Zn2+ Here, we report the closed state structures of the mouse TRPM7 channel domain in three different ionic conditions to overall resolutions of 3.3, 3.7, and 4.1 A.	Zinc	97-101	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	159-164
29944203-4	2018	Through the use of various functional nucleic acids, including aptamers and DNAzymes, as recognition modules, the versatility of D-CID in inducing c-Met signaling upon addition of various small-molecular or ionic cues, including ATP, histidine, and Zn2+ , is demonstrated.	Zinc	249-253	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	147-152
32255071-6	2018	The fluorescence ratios (I570/I450) of SiNPs@GSH-AuNCs are positively correlated with Zn2+ or Cd2+ with the linear range from 1.5 muM to 500 muM.	Zinc	86-90	latexin	Homo sapiens	130-133
32255071-6	2018	The fluorescence ratios (I570/I450) of SiNPs@GSH-AuNCs are positively correlated with Zn2+ or Cd2+ with the linear range from 1.5 muM to 500 muM.	Zinc	86-90	latexin	Homo sapiens	141-144
29560789-7	2018	Lipase and lysozyme immobilized in PPs-Zn exhibited excellent reuse stability.	Zinc	39-41	lysozyme	Homo sapiens	11-19
29181820-6	2018	POF group had significantly lower levels of Zn, Cu, Se, and Zn:Cu ratio.	Zinc	44-46	POF1B actin binding protein	Homo sapiens	0-3
29181820-6	2018	POF group had significantly lower levels of Zn, Cu, Se, and Zn:Cu ratio.	Zinc	60-62	POF1B actin binding protein	Homo sapiens	0-3
29181820-10	2018	Inter-element association between Zn and Se was significant in POF (r = - 0.39, p = 0.02) compared to control group (r = - 0.078, p = 0.65).	Zinc	34-36	POF1B actin binding protein	Homo sapiens	63-66
29856089-5	2018	ZnT3 packages Zn2+ into synaptic vesicles to be released as a long-term modulator of synaptic activity.	Zinc	14-18	solute carrier family 30 member 3	Homo sapiens	0-4
29858979-4	2018	RESULTS: The S100 family is composed of Ca2+ and Zn2+ binding proteins, which are present only in vertebrates.	Zinc	49-53	S100 calcium binding protein B	Homo sapiens	13-17
29655609-6	2018	The results demonstrate how low molecular weight active site Zn(II) chelating compounds can inhibit a range of clinically relevant MBLs and provide additional evidence for the potential of rhodanines to be hydrolysed to potent inhibitors of MBL protein fold and, maybe, other metallo-enzymes, perhaps contributing to the complex biological effects of rhodanines.	Zinc	61-63	mannose-binding lectin family member 3, pseudogene	Homo sapiens	131-134
29965732-3	2018	In the Zn(II)-Dy(III) (1-4) system, the coordination environments of the Dy(III) ions are nearly identical, but the apical coordination atom to the Zn(II) ion is different.	Zinc	7-13	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	17-20
29965732-3	2018	In the Zn(II)-Dy(III) (1-4) system, the coordination environments of the Dy(III) ions are nearly identical, but the apical coordination atom to the Zn(II) ion is different.	Zinc	7-13	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	76-79
29965732-3	2018	In the Zn(II)-Dy(III) (1-4) system, the coordination environments of the Dy(III) ions are nearly identical, but the apical coordination atom to the Zn(II) ion is different.	Zinc	148-154	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	17-20
29965732-6	2018	From this work, the key factors that significantly affect the SMM performance of these heteronuclear Zn(II)/Co(III)-Dy(III) SMMs are unambiguously presented.	Zinc	101-103	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	108-115
29965732-6	2018	From this work, the key factors that significantly affect the SMM performance of these heteronuclear Zn(II)/Co(III)-Dy(III) SMMs are unambiguously presented.	Zinc	101-103	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	111-114
29957993-3	2018	Several facts are now established: the presence of large amount of d-block (M) ions (Zn, Cu, and Fe) in the aggregated forms; the 1:1 M/Abeta ratio favors the formation of amorphous aggregates, with an aggregation rate lower than that in the absence of such ions.	Zinc	85-87	amyloid beta precursor protein	Homo sapiens	136-141
29771714-18	2018	CONCLUSIONS: Rem maintains Zn homeostasis at reperfusion by inhibiting MTF1 and ZnT1 expression, leading to the attenuation of ER stress and cardiac injury.	Zinc	27-29	metal-regulatory transcription factor 1	Rattus norvegicus	71-75
29991716-3	2018	As one of the underlying mechanisms of Cu, Zn superoxide dismutase (SOD1) gene mutation-induced ALS, SOD1 mutants (SOD1mut) commonly interact with an endoplasmic reticulum-resident membrane protein Derlin-1, triggering motoneuron death.	Zinc	43-45	superoxide dismutase 1, soluble	Mus musculus	68-72
29991716-3	2018	As one of the underlying mechanisms of Cu, Zn superoxide dismutase (SOD1) gene mutation-induced ALS, SOD1 mutants (SOD1mut) commonly interact with an endoplasmic reticulum-resident membrane protein Derlin-1, triggering motoneuron death.	Zinc	43-45	superoxide dismutase 1, soluble	Mus musculus	101-105
29991716-3	2018	As one of the underlying mechanisms of Cu, Zn superoxide dismutase (SOD1) gene mutation-induced ALS, SOD1 mutants (SOD1mut) commonly interact with an endoplasmic reticulum-resident membrane protein Derlin-1, triggering motoneuron death.	Zinc	43-45	superoxide dismutase 1, soluble	Mus musculus	101-105
29775292-3	2018	HDAC6 inhibitors generally consist of a Zn2+-binding group such as a hydroxamate, a linker, and a capping group; the capping group is a critical determinant of isozyme selectivity.	Zinc	40-44	histone deacetylase 6	Homo sapiens	0-5
29791142-15	2018	Accordingly, the substrate selectivity of ZIP2 decreases in the following order: Zn2+ &gt; Cd2+ &gt;= Cu2+ &gt; Co2+.	Zinc	81-85	solute carrier family 39 member 2	Homo sapiens	42-46
29364645-9	2018	Caspase-3, -7, and -8 were found to bind three, one, and two zincs, respectively.	Zinc	61-66	caspase 3	Homo sapiens	0-21
29635136-6	2018	In osteoblast differentiation, silibinin and Zn-silibinin complexes enhanced osteoblast differentiation at the cellular level by increasing calcium deposition and ALP activity, and at molecular level increased osteoblast markers include Runx2, type 1 col, ALP and OC mRNAs expression.	Zinc	45-47	alopecia, recessive	Mus musculus	163-166
29635136-6	2018	In osteoblast differentiation, silibinin and Zn-silibinin complexes enhanced osteoblast differentiation at the cellular level by increasing calcium deposition and ALP activity, and at molecular level increased osteoblast markers include Runx2, type 1 col, ALP and OC mRNAs expression.	Zinc	45-47	alopecia, recessive	Mus musculus	256-259
29198021-10	2018	Zn exposure substantially reduced UPS-associated trypsin-like, chymotrypsin-like, and caspase-like activities along with the expression of SUG1 and beta-5 subunits of UPS in the nigrostriatal tissues of exposed groups.	Zinc	0-2	adaptor related protein complex 5 subunit beta 1	Rattus norvegicus	148-154
29501034-5	2018	The results showed that the half maximal inhibitory concentration (IC50) values of Zn2+, Cu2+, OTC and SMZ on PN sludge were 50.1, 35.4, 447 and 1890 mg L-1, respectively.	Zinc	83-87	immunoglobulin kappa variable 1-16	Homo sapiens	153-156
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	NSE3 homolog, SMC5-SMC6 complex component	Homo sapiens	102-108
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	NSE3 homolog, SMC5-SMC6 complex component	Homo sapiens	288-292
29702030-5	2018	Our study showed that supplementation with Zn prevented renal dysfunction as indicated by plasma biomarkers (urea, uric acid, creatinine, lactate dehydrogenase, and alkaline phosphatase levels) and oxidative stress-related parameters (thiobarbituric acid reactive substances, protein carbonyl, advanced oxidation protein product, superoxide dismutase, catalase, glutathione peroxidase, and vitamins (A, E)) in kidney tissue.	Zinc	43-45	catalase	Rattus norvegicus	352-360
29774745-6	2018	Enzyme inhibition at high Zn2+ concentrations ( Ki = 20 muM) further suggests a mechanism for modulating NEP activity, Abeta4-9 production, and Cu2+ homeostasis.	Zinc	26-30	membrane metalloendopeptidase	Homo sapiens	105-108
29750435-6	2018	Zn2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A-tyrosine kinase Src (Src)-epidermal growth factor receptor and phospholipase C. Both the transmembrane AC and the soluble-AC are involved in the stimulation of HAM by Zn2+ .	Zinc	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
29750435-6	2018	Zn2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A-tyrosine kinase Src (Src)-epidermal growth factor receptor and phospholipase C. Both the transmembrane AC and the soluble-AC are involved in the stimulation of HAM by Zn2+ .	Zinc	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	174-177
29748523-1	2018	Two unprecedented homometallic CoII and ZnII coordination compounds, [M2(L)(OCH3)][M2(L)(OAc)] (MII = CoII (1) and ZnII (2)), with a novel symmetric bis(salamo)-like tetraoxime ligand H3L were synthesized and characterized by elemental analyses, infrafred (IR), ultraviolet-visible spectroscopy (UV-Vis), fluorescent spectra and single-crystal X-ray diffraction analyses.	Zinc	115-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
29281262-0	2018	Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays.	Zinc	11-17	nerve growth factor	Homo sapiens	79-98
29343315-1	2018	OBJECTIVE: To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations.	Zinc	93-95	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	61-64
29414334-8	2018	Cd, Cr, Cu, Hg, Ni, Pb, and Zn) - have been detected in all wastewater samples at sub-mg L-1 levels.	Zinc	28-30	immunoglobulin kappa variable 1-16	Homo sapiens	89-92
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Zinc	149-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
29282888-0	2018	Comprehensive study of interaction between biocompatible PEG-InP/ZnS QDs and bovine serum albumin.	Zinc	65-68	albumin	Homo sapiens	84-97
29630837-5	2018	In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +- 1 and 490 +- 20 muM.	Zinc	230-236	phosphohistidine phosphatase 1	Homo sapiens	57-62
29468392-3	2018	High level of Zn led to reduce dry mass, chlorophyll pigments, fruit yield, leaf maximum fluorescence, and relative water content, but enhanced endogenous hydrogen peroxide (H2O2), free proline, malondialdehyde (MDA), electrolyte leakage (EL), H2S, as well as the activities of peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) enzymes.	Zinc	14-16	peroxidase P7	Capsicum annuum	278-288
29468392-3	2018	High level of Zn led to reduce dry mass, chlorophyll pigments, fruit yield, leaf maximum fluorescence, and relative water content, but enhanced endogenous hydrogen peroxide (H2O2), free proline, malondialdehyde (MDA), electrolyte leakage (EL), H2S, as well as the activities of peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) enzymes.	Zinc	14-16	peroxidase P7	Capsicum annuum	290-293
29355498-5	2018	While brief (5 min) neuronal depolarization (to activate VSCC) in the presence of 300 muM Zn2+ causes substantial delayed neurodegeneration, it only mildly impacts acute mitochondrial function, raising questions as to contributions of Zn2+-induced mitochondrial dysfunction to neuronal injury.	Zinc	90-94	latexin	Homo sapiens	86-89
29548726-7	2018	A decrease in the expression of the gene encoding the neuro-trophic factor (BDNF) associated with overexpression of the encoding the metal regulatory transcription factor 1 (MTF1), factor involved in the homeostasis of Zn, was also noted in Cd group.	Zinc	219-221	metal-regulatory transcription factor 1	Rattus norvegicus	133-172
29548726-7	2018	A decrease in the expression of the gene encoding the neuro-trophic factor (BDNF) associated with overexpression of the encoding the metal regulatory transcription factor 1 (MTF1), factor involved in the homeostasis of Zn, was also noted in Cd group.	Zinc	219-221	metal-regulatory transcription factor 1	Rattus norvegicus	174-178
29367051-14	2018	The influence of NO3-, NO2-, IC and heavy metal Pb and Zn on bacterial community might via their influence on the functional groups involving nitrogen, carbon and metal metabolisms.	Zinc	55-57	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29351417-6	2018	Extracellular Zn2+ promoted vascular cell survival/growth through activation of cAMP and Akt as well as overexpressing of platelet-derived growth factor-alpha receptor and vascular endothelial growth factor A.	Zinc	14-18	AKT serine/threonine kinase 1	Homo sapiens	89-92
29351417-6	2018	Extracellular Zn2+ promoted vascular cell survival/growth through activation of cAMP and Akt as well as overexpressing of platelet-derived growth factor-alpha receptor and vascular endothelial growth factor A.	Zinc	14-18	vascular endothelial growth factor A	Homo sapiens	172-208
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	prostaglandin I2 synthase	Homo sapiens	184-209
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	nitric oxide synthase 3	Homo sapiens	214-237
29355498-7	2018	Mild disruption of cytosolic Zn2+ buffering-while having little effects alone-markedly enhanced mitochondrial Zn2+ accumulation and dysfunction (including loss of  Psim, ROS generation, swelling and respiratory inhibition) caused by relatively low (10-50 muM) Zn2+ with high K+.	Zinc	29-33	latexin	Homo sapiens	255-258
28455702-2	2018	Recently, we described zinc non-competitive interactions toward agonist binding at serotonin 5-HT1A receptors, in which biphasic effects, involving potentiation at sub-micromolar concentrations (10 muM) and inhibition at sub-millimolar concentrations (500 muM) of Zn2+ in radioligand binding assays, were consistent with both the agonist and antagonist-like effects of zinc ions observed in in vivo studies.	Zinc	264-268	latexin	Homo sapiens	198-201
28990230-12	2018	Nano Zn-administered group showed a non-significant downregulation of MUC2 gene.	Zinc	5-7	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	70-74
28455702-2	2018	Recently, we described zinc non-competitive interactions toward agonist binding at serotonin 5-HT1A receptors, in which biphasic effects, involving potentiation at sub-micromolar concentrations (10 muM) and inhibition at sub-millimolar concentrations (500 muM) of Zn2+ in radioligand binding assays, were consistent with both the agonist and antagonist-like effects of zinc ions observed in in vivo studies.	Zinc	264-268	latexin	Homo sapiens	256-259
29210568-0	2018	Comparison of the Response of Bacterial IscU and SufU to Zn2+ and Select Transition-Metal Ions.	Zinc	57-61	iron-sulfur cluster assembly enzyme	Homo sapiens	40-44
29381858-0	2018	Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.	Zinc	29-35	S100 calcium binding protein A1	Homo sapiens	59-63
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A1	Homo sapiens	42-46
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A12	Homo sapiens	162-169
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A12	Homo sapiens	171-184
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A7	Homo sapiens	191-197
29555950-2	2018	Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-beta (Abeta), and is enriched in senile plaques in brain of AD patients.	Zinc	6-8	amyloid beta precursor protein	Homo sapiens	54-66
29555950-2	2018	Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-beta (Abeta), and is enriched in senile plaques in brain of AD patients.	Zinc	6-8	amyloid beta precursor protein	Homo sapiens	68-73
29555950-3	2018	To understand Zn-chelated Abeta (ZnAbeta) species, here we systematically characterized ZnAbeta aggregates by incubating equimolar Abeta with Zn.	Zinc	14-16	amyloid beta precursor protein	Homo sapiens	26-31
29528355-2	2018	AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl2] = 0-300 muM).	Zinc	75-81	latexin	Homo sapiens	121-124
29528355-4	2018	AQA-F has a binding constant, Kd = 15.2 muM with Zn(ii).	Zinc	49-55	latexin	Homo sapiens	40-43
29210568-0	2018	Comparison of the Response of Bacterial IscU and SufU to Zn2+ and Select Transition-Metal Ions.	Zinc	57-61	SUFU negative regulator of hedgehog signaling	Homo sapiens	49-53
29210568-1	2018	IscU, the central scaffold protein in the bacterial ISC iron-sulfur (Fe-S) cluster biosynthesis system, has long been recognized to bind a Zn2+ ion at its active site.	Zinc	139-143	iron-sulfur cluster assembly enzyme	Homo sapiens	0-4
29210568-2	2018	While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis.	Zinc	41-45	iron-sulfur cluster assembly enzyme	Homo sapiens	100-104
29210568-2	2018	While initially regarded as an artifact, Zn2+ binding has been shown to induce stabilization of the IscU structure that may mimic a state biologically relevant to IscU"s role in Fe-S cluster biosynthesis.	Zinc	41-45	iron-sulfur cluster assembly enzyme	Homo sapiens	163-167
29210568-3	2018	More recent studies have revealed that SufU, a homologous protein involved in Fe-S cluster biosynthesis in Gram-positive bacteria, also binds a Zn2+ ion with structural implications.	Zinc	144-148	SUFU negative regulator of hedgehog signaling	Homo sapiens	39-43
29217180-5	2018	PAEs interact with the key residues such as Arg47 and Trp191 and lie within the 4A vicinity of zinc metal at the active site of hACMSD.	Zinc	95-105	aminocarboxymuconate semialdehyde decarboxylase	Homo sapiens	128-134
29443339-5	2018	Furthermore, the isostructural ZnII analogue (5) has been prepared to examine the influence of dipolar interactions between adjacent CoII centres and magnetic dilution experiments were performed.	Zinc	31-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-137
29562094-4	2018	At pH 9.0, the affinity of both generations towards heavy metal ions was also observed in the decreasing order of Zn(II) &gt; Co(II) &gt; Ni(II) &gt; Cu(II) &gt; Cd(II).	Zinc	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
29314339-1	2018	A series of heterodinuclear complexes, M-1-PtX2 with M=H2 , Zn, Cu or Co, X=Cl or I, has been synthesized, and first results on their photocatalytic activity in visible light driven proton reduction are presented.	Zinc	60-62	paired like homeodomain 2	Homo sapiens	43-47
29272769-5	2018	Anaerobic ammonia-oxidizing bacteria (AAOB) had self-adaption to Zn (II) in 1-10 mg L-1 and was significantly enhanced after long-term acclimatization, while the suppression threshold was 20 mg L-1.	Zinc	65-72	immunoglobulin kappa variable 1-16	Homo sapiens	84-87
29491387-6	2018	A3H has a highly positively charged surface surrounding the Zn-active center, and multiple positively charged residues within this charged surface play an important role in the RNA-mediated HMW formation and deaminase inhibition.	Zinc	60-62	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	0-3
29413101-0	2018	The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes.	Zinc	26-28	AKT serine/threonine kinase 1	Homo sapiens	32-35
29372915-0	2018	Removal of the Fe(iii) site promotes activation of the human cystic fibrosis transmembrane conductance regulator by high-affinity Zn(ii) binding.	Zinc	130-136	CF transmembrane conductance regulator	Homo sapiens	61-112
29372915-6	2018	Here, Fe3+-insensitive mutations at the R-ICL3 interface were employed to further examine whether Zn2+ potentiated the activity of the human CFTR channel by targeting C1344 once the interfacial Fe3+ bridge was disrupted.	Zinc	98-102	CF transmembrane conductance regulator	Homo sapiens	141-145
29372915-9	2018	Thus, the high-affinity binding of Zn2+ to C1344 in NBD2 may stimulate human CFTR activity in a phosphorylation-dependent manner, but the primary binding of Fe3+ to the ICL3-R interface may prohibit this stimulation.	Zinc	35-39	CF transmembrane conductance regulator	Homo sapiens	77-81
29503658-0	2018	Contribution of NtZIP1-Like to the Regulation of Zn Homeostasis.	Zinc	49-51	zinc transporter 5-like	Nicotiana tabacum	16-22
29503658-4	2018	Following exposure to high Zn there was upregulation of NtZIP11-like, NtNRAMP3, three isoforms of NtMTP2, three MRP/ABCC genes (NtMRP5-like, NtMRP10-like, and NtMRP14 like) and downregulation of NtZIP1-like and NtZIP4.	Zinc	27-29	zinc transporter 5-like	Nicotiana tabacum	56-62
29503658-6	2018	Further detailed analysis of NtZIP1-like provided evidence that it is localized at the plasma membrane and is involved in Zn but not Fe and Cd transport.	Zinc	122-124	zinc transporter 5-like	Nicotiana tabacum	29-35
29503658-9	2018	Thus NtZIP1-like is unlikely to be responsible for Zn uptake by the root apical region but rather in the uptake by root cells within the already mature basal zone.	Zinc	51-53	zinc transporter 5-like	Nicotiana tabacum	5-11
29363685-5	2018	With the characteristic emission lines of Zn 213.9 nm, Cd 228.8 nm and Hg 253.7 nm as the analytical lines for quantification, the detection limits for the simultaneous determination of Zn, Cd and Hg are 22, 1.6, and 10 mug L-1, respectively, and the corresponding linear ranges are 70-6000, 5-1000, and 35-2000 mug L-1, respectively.	Zinc	186-188	immunoglobulin kappa variable 1-16	Homo sapiens	224-227
29440746-8	2018	Furthermore, using an Ni wire-implanted mouse model, we found that Ni wire-induced expression of mouse macrophage inflammatory protein-2 (MIP-2) and cyclooxygenase-2 (COX-2) mRNA in the skin tissue surrounding the wire were enhanced by low Zn conditions.	Zinc	240-242	chemokine (C-X-C motif) ligand 2	Mus musculus	103-136
29372742-5	2018	Owing to its activated phosphine and sulfur atoms, the THTP molecule is a dual anionic precursor for both InP and ZnS QDs.	Zinc	114-117	thiamine triphosphatase	Homo sapiens	55-59
29594524-5	2018	The chelation between Zn(II) of ZnA and the amino groups or hydroxy groups of the template nonapeptides warrants good recognition and capture of Cyt c.	Zinc	22-28	cytochrome c, somatic	Homo sapiens	145-150
29594524-13	2018	The chelation between Zn(II) of the functional monomer zinc(II) acrylate and the amino groups or hydroxy groups of template warrants that the material recognizes and captures cytochrome c well, and this results in fluorescence quenching.	Zinc	22-28	cytochrome c, somatic	Homo sapiens	175-187
29091730-3	2018	Equilibrium dialysis and metal analysis studies revealed that 2 equiv of AMA effectively removes 1 equiv of Zn(II) from MBLs NDM-1, VIM-2, and IMP-7 when the MBL is at micromolar concentrations.	Zinc	108-110	mannose-binding lectin family member 3, pseudogene	Homo sapiens	120-123
29363685-5	2018	With the characteristic emission lines of Zn 213.9 nm, Cd 228.8 nm and Hg 253.7 nm as the analytical lines for quantification, the detection limits for the simultaneous determination of Zn, Cd and Hg are 22, 1.6, and 10 mug L-1, respectively, and the corresponding linear ranges are 70-6000, 5-1000, and 35-2000 mug L-1, respectively.	Zinc	186-188	immunoglobulin kappa variable 1-16	Homo sapiens	316-319
28736190-5	2018	Results show very good agreement between the computed solubility values and experimental data for ZnO bulk, up to 0.5 mg L-1 and equivalents of 50 mug L-1 for the free Zn2+ cation in solution.	Zinc	168-172	immunoglobulin kappa variable 1-16	Homo sapiens	151-154
29337306-7	2018	Consistent with the in vivo observations, knockdown of SLC39A8 in HUVECs decreased ADAMTS1 transcription by decreasing cellular Zn uptake and, as a result, MTF1 transcriptional activity.	Zinc	128-130	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	Mus musculus	83-90
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	RUNX family transcription factor 2	Homo sapiens	120-125
29124566-7	2018	LPS induced expression of both mRNA and protein of inducible NO synthase; this expression was enhanced by 125 microM Zn2+.	Zinc	117-121	nitric oxide synthase 2	Rattus norvegicus	51-72
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	RUNX family transcription factor 2	Homo sapiens	153-158
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	RUNX family transcription factor 2	Homo sapiens	120-125
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	RUNX family transcription factor 2	Homo sapiens	153-158
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	RUNX family transcription factor 2	Homo sapiens	120-125
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	RUNX family transcription factor 2	Homo sapiens	153-158
29292464-8	2018	Subsequently, Zn2+ can cause the down-regulation of claudin-1, breakage of occludin and ZO-1 rings, and collapse of basolateral F-actin structures.	Zinc	14-18	tight junction protein 1	Canis lupus familiaris	88-92
29292464-10	2018	The ERK1/2 and JNK1/2 pathways may also be involved in the Zn2+-induced TJ opening process, while the activation of matrix metalloproteinase was not observed.	Zinc	59-63	mitogen-activated protein kinase 1	Canis lupus familiaris	4-10
29850654-6	2018	As metal ions can have a certain influence on protein structure and activity, we researched the influences of different concentrations of Cu2+ and Zn2+ on hSOD1 activity at induction and the time of activity detection.	Zinc	147-151	superoxide dismutase 1	Homo sapiens	155-160
29293251-0	2018	Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag-In-Zn-S as a biological entity for tumor recognition.	Zinc	80-84	transferrin	Homo sapiens	25-36
29492208-6	2018	The ability of Zn2+ to protect against oxidative stress via a HIF1alpha-dependent mechanism was investigated using a HIF1alpha knock-down PC3 model.	Zinc	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-71
29492208-6	2018	The ability of Zn2+ to protect against oxidative stress via a HIF1alpha-dependent mechanism was investigated using a HIF1alpha knock-down PC3 model.	Zinc	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-126
29492208-12	2018	HIF1alpha is an integral component of a Zn2+-dependent protective mechanism present in PC3 cells.	Zinc	40-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
28843881-9	2018	Presence of Mg2+, Ba2+ and Zn2+ was found to interfere with VDB-LYZ interaction.	Zinc	27-31	lysozyme	Homo sapiens	64-67
28350488-1	2018	The effects of supplementing the organic forms of selenium (Se), chromium (Cr), and zinc (Zn) on Hsp-70 mRNA expression and body weight in broiler chickens were evaluated.	Zinc	90-92	heat shock protein family A (Hsp70) member 2	Gallus gallus	97-103
28350488-5	2018	Organic Se, Cr, and Zn supplementation significantly (P &lt; 0.05) reduced the expression of Hsp-70 mRNA levels.	Zinc	20-22	heat shock protein family A (Hsp70) member 2	Gallus gallus	93-99
29018994-4	2017	An ecological dose analysis demonstrated that urease was the most sensitive enzyme to Pb and Cd in the farmland, and catalase and phosphatase were the most sensitive enzymes to Pb, Zn, and Cd in the woodland and grassland.	Zinc	181-183	catalase	Homo sapiens	117-125
29283372-9	2017	Curcumin-Cu(II) or -Zn(II) complexes systems significantly enhanced the superoxide dismutase, catalase, and glutathione peroxidase activities and attenuated the increase of malondialdehyde levels and caspase-3 and caspase-9 activities, in a dose-dependent manner.	Zinc	19-26	catalase	Rattus norvegicus	94-102
29283372-9	2017	Curcumin-Cu(II) or -Zn(II) complexes systems significantly enhanced the superoxide dismutase, catalase, and glutathione peroxidase activities and attenuated the increase of malondialdehyde levels and caspase-3 and caspase-9 activities, in a dose-dependent manner.	Zinc	19-26	caspase 9	Rattus norvegicus	214-223
29283372-11	2017	Further mechanistic study demonstrated that curcumin-Cu(II) or -Zn(II) complexes systems inhibited cell apoptosis via downregulating the nuclear factor kappaB (NF-kappaB) pathway and upregulating Bcl-2/Bax pathway.	Zinc	64-70	BCL2, apoptosis regulator	Rattus norvegicus	196-201
29038264-9	2018	These results also reveal that Zn(II) deprivation imposes a strict constraint on the evolution of this MBL, overriding the most common pressures acting on catalytic performance, and shed light on possible inhibitory strategies.	Zinc	31-37	mannose-binding lectin family member 3, pseudogene	Homo sapiens	103-106
28258314-10	2017	However, at high loading rate (e.g., 300 mg L-1) biosolids may be used as an immobilizing agent for Cd, Cu, Pb, Zn and mobilizing agent for Ni.	Zinc	112-114	immunoglobulin kappa variable 1-16	Homo sapiens	44-47
29289532-4	2018	Here, we identified a novel connection between CFTR/ENaC expression and the intracellular Zn2+ concentration in the regulation of MUC5AC, a major secreted mucin that is highly expressed in CF airway.	Zinc	90-94	CF transmembrane conductance regulator	Homo sapiens	47-51
29289532-6	2018	Importantly, DeltaC-ZIP2 levels correlated inversely with wild-type ZIP2 and intracellular Zn2+ levels.	Zinc	91-95	solute carrier family 39 member 2	Homo sapiens	20-24
29114036-6	2017	Here we found that ZnT2 deletion in lactating mice and cultured MECs resulted in Zn2+-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development.	Zinc	81-85	phosphatase and tensin homolog	Mus musculus	142-146
29181469-4	2017	The excellent photocatalytic activity of Er3+-doped Zn/Cu/Al-MPO, especially its strong NIR photoactivity, is ascribed to its Er3+-doped CuO-involved multi-crystalline phase heterostructure, i.e., n-p-n double heterojunctions, which does not only offer an enhanced NIR absorption but also promotes the separation of photogenerated charge carriers.	Zinc	52-54	myeloperoxidase	Homo sapiens	61-64
29181469-5	2017	Importantly, the synergy of all the parts of the n-p-n double heterojuctions plays an important role in interface band structure regulation for the enhancement of the photocatalytic properties of Er3+-doped Zn/Cu/Al-MPO.	Zinc	207-209	myeloperoxidase	Homo sapiens	216-219
29180421-5	2017	Moreover, reduced intracellular Zn concentration in Slc39a10fl/fl;LysM-Cre+ macrophages led to the stabilization of p53, which increased apoptosis upon LPS stimulation.	Zinc	32-34	lysozyme 2	Mus musculus	66-70
29180421-7	2017	Finally, the phenotype in Slc39a10fl/fl;LysM-Cre+ mice was mimicked in wild-type mice using the Zn chelator TPEN and was reversed with Zn supplementation.	Zinc	96-98	lysozyme 2	Mus musculus	40-44
29180421-7	2017	Finally, the phenotype in Slc39a10fl/fl;LysM-Cre+ mice was mimicked in wild-type mice using the Zn chelator TPEN and was reversed with Zn supplementation.	Zinc	135-137	lysozyme 2	Mus musculus	40-44
28258314-9	2017	We conclude that at low loading rate (e.g., 50 mg L-1) biosolids treatment might increase the lability and environmental risk of Cd, Cu, Pb, and Zn.	Zinc	145-147	immunoglobulin kappa variable 1-16	Homo sapiens	50-53
28551866-5	2017	Lm-AlpI catalytic sites contained three metal ion sites (two Zn2+ and one Mg2+), referring to D73, H184, D348, H349, H352, H464, D389, and H390 residues, which are essential for enzymatic activity and conservation in different organisms.	Zinc	61-65	alkaline phosphatase, intestinal	Homo sapiens	3-7
28918363-4	2017	Chronic exposure to Zn accelerated senescence and untreated cells at later passages, where doubling time had increased, displayed relocation of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis.	Zinc	20-22	solute carrier family 30 member 1	Homo sapiens	237-244
28918363-4	2017	Chronic exposure to Zn accelerated senescence and untreated cells at later passages, where doubling time had increased, displayed relocation of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis.	Zinc	20-22	solute carrier family 39 member 6	Homo sapiens	246-253
28918363-4	2017	Chronic exposure to Zn accelerated senescence and untreated cells at later passages, where doubling time had increased, displayed relocation of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis.	Zinc	20-22	solute carrier family 30 member 10	Homo sapiens	264-272
29073545-6	2017	The systematic effort toward comparative work on appropriately defined Zn(II) species and insulin in inducing adipogenesis reveals the salient structural features in the Schiff family of ligands configuring Zn(II) so as to promote complex formation sufficient to engage biomolecular targets during the process of initiation and maturation.	Zinc	207-213	insulin	Homo sapiens	90-97
28972932-1	2017	Interactions of Zn2+ with amyloid beta-protein (Abeta) and the subsequent induction of Abeta aggregation have been implicated in the pathogenesis of Alzheimer"s disease (AD).	Zinc	16-20	amyloid beta precursor protein	Homo sapiens	48-53
28582961-4	2017	The ZnSe/CdS/ZnS QDs are used as fluorescent labels to exploit their application in fluorescence-linked immunosorbent assay (FLISA) for the first time in the detection of C-reactive protein (CRP) with a limit of detection (LOD) of 0.85 ng/mL, which is more sensitive than that of CdSe/ZnS type-I QDs based FLISA (1.00 ng/mL).	Zinc	4-7	C-reactive protein	Homo sapiens	171-189
28582961-4	2017	The ZnSe/CdS/ZnS QDs are used as fluorescent labels to exploit their application in fluorescence-linked immunosorbent assay (FLISA) for the first time in the detection of C-reactive protein (CRP) with a limit of detection (LOD) of 0.85 ng/mL, which is more sensitive than that of CdSe/ZnS type-I QDs based FLISA (1.00 ng/mL).	Zinc	4-7	C-reactive protein	Homo sapiens	191-194
28582961-4	2017	The ZnSe/CdS/ZnS QDs are used as fluorescent labels to exploit their application in fluorescence-linked immunosorbent assay (FLISA) for the first time in the detection of C-reactive protein (CRP) with a limit of detection (LOD) of 0.85 ng/mL, which is more sensitive than that of CdSe/ZnS type-I QDs based FLISA (1.00 ng/mL).	Zinc	13-16	C-reactive protein	Homo sapiens	171-189
28582961-4	2017	The ZnSe/CdS/ZnS QDs are used as fluorescent labels to exploit their application in fluorescence-linked immunosorbent assay (FLISA) for the first time in the detection of C-reactive protein (CRP) with a limit of detection (LOD) of 0.85 ng/mL, which is more sensitive than that of CdSe/ZnS type-I QDs based FLISA (1.00 ng/mL).	Zinc	13-16	C-reactive protein	Homo sapiens	191-194
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	interleukin 15	Gallus gallus	117-121
28965604-4	2017	The aim of the present study was to investigate the long-term influence of Zn2+ chelation on cellular STAT1 levels and their effect on protein levels and activity of iNOS.	Zinc	75-79	nitric oxide synthase 2	Homo sapiens	166-170
29053870-7	2017	Increasing the ZnOHCl content from 50 mg to 100 mg/kg Zn reversed (P &gt; 0.05) the decrease in SOD activity and monocyte cathelicidin mRNA levels of the 50 mg ZnOHCl+45 mg MnOHCL fed group, and increasing the MnOHCl content from 45 mg to 90 mg/kg in the 100 mg ZnOHCl+45 mg MnOHCl group further increased SOD activity.	Zinc	15-17	superoxide dismutase 1	Homo sapiens	96-99
28990619-7	2017	Interestingly, it was found that the IFE efficiency of different PNPP-QD pairs increased almost linearly with the corresponding spectral overlap, and Mn-doped ZnS QDs were eventually chosen for the IFE assay of ALP because of the maximum spectral overlap and thus the best sensitivity.	Zinc	159-162	alkaline phosphatase, placental	Homo sapiens	211-214
29053870-7	2017	Increasing the ZnOHCl content from 50 mg to 100 mg/kg Zn reversed (P &gt; 0.05) the decrease in SOD activity and monocyte cathelicidin mRNA levels of the 50 mg ZnOHCl+45 mg MnOHCL fed group, and increasing the MnOHCl content from 45 mg to 90 mg/kg in the 100 mg ZnOHCl+45 mg MnOHCl group further increased SOD activity.	Zinc	15-17	superoxide dismutase 1	Homo sapiens	306-309
29087184-6	2017	The superoxide dismutase (SOD) activities of the Cu2+/Cu2+ and Cu2+/Zn2+ complexes of L1 and L2 have been evaluated using nitro blue tetrazolium assays at pH 7.4.	Zinc	68-72	superoxide dismutase 1	Homo sapiens	26-29
29087184-6	2017	The superoxide dismutase (SOD) activities of the Cu2+/Cu2+ and Cu2+/Zn2+ complexes of L1 and L2 have been evaluated using nitro blue tetrazolium assays at pH 7.4.	Zinc	68-72	L1 cell adhesion molecule	Homo sapiens	86-95
28865957-9	2017	The Zn(II) binding profile of MT2a was compared to Zn(II) binding profile of human kidney MT1a, which was reported in literature, and found that the Zn(II) binding profile of MT2a is similar to that of MT1a.	Zinc	51-57	metallothionein 1A	Homo sapiens	90-94
28865957-9	2017	The Zn(II) binding profile of MT2a was compared to Zn(II) binding profile of human kidney MT1a, which was reported in literature, and found that the Zn(II) binding profile of MT2a is similar to that of MT1a.	Zinc	51-57	metallothionein 1A	Homo sapiens	90-94
28150441-4	2017	In contrast, the binding of fibrinogen-EuP-82 in the condition with the inhibitor (Zn2+ ) was an unfavorable endothermic reaction.	Zinc	83-87	fibrinogen beta chain	Homo sapiens	28-38
28802646-5	2017	In this study, we show that zinc, (Zn) a short-acting NMDAR antagonist evokes only transient ERK activation, which is observed 7 min after its administration in the PFC of rats.	Zinc	34-37	Eph receptor B1	Rattus norvegicus	93-96
29245902-3	2017	Specifically, we initially found that high level of Zn2+ upregulates the expression of COX-2 via stimulating the activity of TNF-alpha in a zinc transporter 3 (ZnT3)-dependent mechanism.	Zinc	52-56	tumor necrosis factor	Mus musculus	125-134
29154026-6	2017	There are now several examples of MBL inhibitors that operate either in a Zn-dependent or Zn-independent mode.	Zinc	74-76	mannose-binding lectin family member 3, pseudogene	Homo sapiens	34-37
29154026-6	2017	There are now several examples of MBL inhibitors that operate either in a Zn-dependent or Zn-independent mode.	Zinc	90-92	mannose-binding lectin family member 3, pseudogene	Homo sapiens	34-37
28697633-8	2017	Moreover, our present findings suggest that the effects of ZnC on NO production, HO-1 expression, and Nrf2 activation were attributed to its Zn subcomponent, but not l-carnosine.	Zinc	59-61	heme oxygenase 1	Mus musculus	81-85
28849014-1	2017	Zinc (Zn) deficiency is important for inducing nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing-3 (NLRP3) inflammasome activation in macrophages.	Zinc	6-8	NLR family pyrin domain containing 3	Homo sapiens	143-148
28849014-6	2017	It was found that Zn supplementation inhibited HG-induced NLRP3 inflammasome activation in the HPMCs by attenuating ROS production.	Zinc	18-20	NLR family pyrin domain containing 3	Homo sapiens	58-63
28849014-7	2017	Further experiments revealed that Zn supplementation inhibited the HG-induced production of ROS through activation of the Nrf2 antioxidant pathway.	Zinc	34-36	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
28849014-8	2017	These results indicated that Zn inhibited NLRP3 inflammasome activation in the HG-treated HPMCs by activating the Nrf2 antioxidant pathway and reducing the production of ROS.	Zinc	29-31	NLR family pyrin domain containing 3	Homo sapiens	42-47
28849014-8	2017	These results indicated that Zn inhibited NLRP3 inflammasome activation in the HG-treated HPMCs by activating the Nrf2 antioxidant pathway and reducing the production of ROS.	Zinc	29-31	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
28261760-9	2017	X-ray exposure also caused a significant increase in the levels of lipid peroxidation as well as activities of catalase and superoxide dismutase, which however were decreased upon simultaneous Zn treatment.	Zinc	193-195	catalase	Rattus norvegicus	111-119
28833062-5	2017	ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia.	Zinc	39-43	cadherin 1	Homo sapiens	115-125
28833062-5	2017	ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia.	Zinc	39-43	solute carrier family 39 member 6	Homo sapiens	0-4
28802646-6	2017	In contrast to Zn, the long acting NMDAR antagonist Ro 25-6981 produces persistent ERK activation lasting up to 24 h. Pretreatment with the MAPK/ERK inhibitor (U0126) totally abolished Zn and Ro 25-6981 antidepressant-like activities in the forced swim test in rats.	Zinc	185-187	Eph receptor B1	Rattus norvegicus	83-86
28802646-6	2017	In contrast to Zn, the long acting NMDAR antagonist Ro 25-6981 produces persistent ERK activation lasting up to 24 h. Pretreatment with the MAPK/ERK inhibitor (U0126) totally abolished Zn and Ro 25-6981 antidepressant-like activities in the forced swim test in rats.	Zinc	185-187	Eph receptor B1	Rattus norvegicus	145-148
28979942-4	2017	Here, we report a highly brain penetrant HDAC6 inhibitor, Bavarostat, that exhibits excellent HDAC6 selectivity (&gt;80-fold over all other Zn-containing HDAC paralogues), modulates tubulin acetylation selectively over histone acetylation, and has excellent brain penetrance.	Zinc	140-142	histone deacetylase 6	Homo sapiens	41-46
28771859-5	2017	Functional complementation of the zrt1/zrt2 yeast mutant by TaZIP3, -6, -7, -9 and -13 supported an ability to transport Zn.	Zinc	121-123	zinc transporter 7	Triticum aestivum	60-86
28582666-9	2017	An ELISA-like assay with CdSe/ZnS quantum dot institution (QLISA; Quantum dot-linked immunosorbent assay) was developed to detect 0.05ng/mL IL-6, which makes it sufficiently sensitive as an immunosorbent assay.	Zinc	30-33	interleukin 6	Homo sapiens	140-144
28948484-1	2017	In this work, hydrozincite and Zn/Al-CO32- hydrotalcite supported on silica aerogel were prepared via a simple and economical process and used as adsorbents for Pb(II) removal.	Zinc	31-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	161-167
28948484-3	2017	In the batch Pb(II) adsorption experiments, the adsorbents with higher Zn(II) contents showed higher Pb(II) adsorption capacities, and the adsorption data fitted well with the Langmuir isotherm model and pseudo-second-order kinetic model, indicating a mechanism of surface chemisorption.	Zinc	71-77	submaxillary gland androgen regulated protein 3B	Homo sapiens	13-19
28948484-3	2017	In the batch Pb(II) adsorption experiments, the adsorbents with higher Zn(II) contents showed higher Pb(II) adsorption capacities, and the adsorption data fitted well with the Langmuir isotherm model and pseudo-second-order kinetic model, indicating a mechanism of surface chemisorption.	Zinc	71-77	submaxillary gland androgen regulated protein 3B	Homo sapiens	101-107
28948484-5	2017	The XRD diffraction peaks of hydrozincite and Zn/Al-CO32- hydrotalcite disappeared after the adsorption, and the Pb(II) species were uniformly dispersed in the adsorbents in form of Pb3(CO3)2(OH)2 proven by TEM, EDS mapping and XRD analysis, demonstrating the nature of the adsorption is the precipitation conversion of hydrozincite or Zn/Al-CO32- hydrotalcite into Pb3(CO3)2(OH)2.	Zinc	336-338	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
28948484-6	2017	These results demonstrate the synergic Pb(II) removal effect of the CO32- and OH- derived from hydrozincite and Zn/Al-CO32- hydrotalcite together with their ultra-thin thickness and high surface area contribute the excellent properties of the adsorbents.	Zinc	112-114	submaxillary gland androgen regulated protein 3B	Homo sapiens	39-45
28739258-4	2017	Here we have investigated the effect of divalent metal ions (Cd2+, Cu2+, Mg2+, Mn2+, Ni2+, and Zn2+) on the structural integrity and catalytic activity of hHint1.	Zinc	95-99	histidine triad nucleotide binding protein 1	Homo sapiens	155-161
28739258-5	2017	With the exception of Mg2+, all the divalent ions inhibited hHint1, the rank of order was found to be Cu2+ &gt;Zn2+ &gt;Cd2+ &gt;=Ni2+ &gt;Mn2+ based on their IC50 and kin/KI values.	Zinc	111-115	histidine triad nucleotide binding protein 1	Homo sapiens	60-66
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	31-35	amyloid beta precursor protein	Homo sapiens	47-52
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	31-35	amyloid beta precursor protein	Homo sapiens	78-83
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	31-35	amyloid beta precursor protein	Homo sapiens	78-83
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	31-35	latexin	Homo sapiens	160-163
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	57-61	amyloid beta precursor protein	Homo sapiens	78-83
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	57-61	amyloid beta precursor protein	Homo sapiens	78-83
28621929-2	2017	Here we report the kinetics of Zn2+ binding to Abeta and Zn2+/Cu2+ binding to Abeta-Cu to form ternary complexes under near physiological conditions (nM Abeta, muM metal ions).	Zinc	57-61	latexin	Homo sapiens	160-163
28855827-2	2017	Four different concentrations (0, 25, 50 and 100 muM L-1) of Zn chelate and sulfate were used to study the antioxidant system of Phaseolus vulgaris L. Three genes related with antioxidant activity [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] were selected for expression study.	Zinc	61-63	immunoglobulin kappa variable 1-16	Homo sapiens	53-56
28820252-0	2017	Computational Study on M1/POM Single-Atom Catalysts (M = Cu, Zn, Ag, and Au; POM = [PW12O40]3-): Metal-Support Interactions and Catalytic Cycle for Alkene Epoxidation.	Zinc	61-63	myoregulin	Homo sapiens	23-29
28820252-4	2017	The calculated adsorption energy of isolated metal atoms in these M1/POM SACs indicates that the early transition metals (Cu and Zn) have high thermal stability.	Zinc	129-131	myoregulin	Homo sapiens	66-72
28729223-3	2017	These polymeric Schiff base ligands, SBOPA and SBPBA generates polymeric metal complexes in high yields on reaction with transition metal acetates, M(CH3COO)2.xH2O where M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II).	Zinc	209-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	182-188
28729223-6	2017	On the basis of FT-IR, 1HNMR, electronic spectra and magnetic moment values Mn(II), Co(II) and Ni(II) ion were found to have octahedral geometry while Cu(II) and Zn(II) were found to be square-planar in nature.	Zinc	162-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-90
28124217-6	2017	In case of the autoimmune disorders, the highest Cu concentration was determined in the Alb-containing protein fractions while the Zn level decreased in the Alb and increased in the Cp as well as in the IgG- and Trf-containing fractions compared to the healthy samples.	Zinc	131-133	albumin	Homo sapiens	157-160
27555441-0	2017	Computational simulation analysis on human SOD1 mutant (H80R) exposes the structural destabilization and the deviation of Zn binding that directs familial amyotrophic lateral sclerosis.	Zinc	122-124	superoxide dismutase 1	Homo sapiens	43-47
28855827-6	2017	SOD activity shows differences in both forms of Zn, chelate form was different at 25, 50 and 100 muM L-1 with less activity at 100 muM L-1 and sulfate treatment shows differences in all concentrations used.	Zinc	48-50	superoxide dismutase 1	Homo sapiens	0-3
28855827-6	2017	SOD activity shows differences in both forms of Zn, chelate form was different at 25, 50 and 100 muM L-1 with less activity at 100 muM L-1 and sulfate treatment shows differences in all concentrations used.	Zinc	48-50	immunoglobulin kappa variable 1-16	Homo sapiens	101-104
28855827-3	2017	Results showed that when Zn chelate at 50 and 100 muM L-1 were applied SOD was repressed and GSH-Px expression was low at 0, 25 and 100 muM L-1 while with sulfate form SOD expression was low and GSH-Px expression was strong in all treatment.	Zinc	25-27	immunoglobulin kappa variable 1-16	Homo sapiens	54-57
28855827-3	2017	Results showed that when Zn chelate at 50 and 100 muM L-1 were applied SOD was repressed and GSH-Px expression was low at 0, 25 and 100 muM L-1 while with sulfate form SOD expression was low and GSH-Px expression was strong in all treatment.	Zinc	25-27	superoxide dismutase 1	Homo sapiens	71-74
28855827-3	2017	Results showed that when Zn chelate at 50 and 100 muM L-1 were applied SOD was repressed and GSH-Px expression was low at 0, 25 and 100 muM L-1 while with sulfate form SOD expression was low and GSH-Px expression was strong in all treatment.	Zinc	25-27	immunoglobulin kappa variable 1-16	Homo sapiens	140-143
28855827-3	2017	Results showed that when Zn chelate at 50 and 100 muM L-1 were applied SOD was repressed and GSH-Px expression was low at 0, 25 and 100 muM L-1 while with sulfate form SOD expression was low and GSH-Px expression was strong in all treatment.	Zinc	25-27	superoxide dismutase 1	Homo sapiens	168-171
28676269-4	2017	This result suggests that this new inhibitor interacts within the S1, S1" domain of NEP allowing a pentacoordination of the catalytic Zn2+ ion by the mercaptoketone moiety.	Zinc	134-138	membrane metalloendopeptidase	Homo sapiens	84-87
28058664-12	2017	Elemental Zn showed an inverse relationship with MDA, NO, and CRP but positively correlated with antioxidant capacity, whereas MDA showed a positive correlation with CRP level.	Zinc	10-12	C-reactive protein	Homo sapiens	62-65
28792450-4	2017	The limits of detection for the simultaneous determination of zinc, cadmium, copper and lead on the screen printed electrodes were found to be 350 microg L-1 for Zn(II), 25 microg L-1 for Cd(II), 3 microg L-1 for Pb(II) and 3 microg L-1 for Cu(II).	Zinc	162-168	L1 cell adhesion molecule	Homo sapiens	154-157
28058664-13	2017	Thus, we conclude that attenuated level of Zn and antioxidant in serum play an important role in the inflammatory status of CLD patients by elevating the concentration of MDA, NO, and CRP.	Zinc	43-45	C-reactive protein	Homo sapiens	184-187
28677078-1	2017	Bovine apo-transferrin (Tf) dose-dependently inhibited zinc (Zn) measurement if apo-Tf was added to a Zn standard solution followed by Zn measurement using a commercial Zn assay kit.	Zinc	61-63	serotransferrin	Bos taurus	11-22
28677078-1	2017	Bovine apo-transferrin (Tf) dose-dependently inhibited zinc (Zn) measurement if apo-Tf was added to a Zn standard solution followed by Zn measurement using a commercial Zn assay kit.	Zinc	102-104	serotransferrin	Bos taurus	11-22
28677078-1	2017	Bovine apo-transferrin (Tf) dose-dependently inhibited zinc (Zn) measurement if apo-Tf was added to a Zn standard solution followed by Zn measurement using a commercial Zn assay kit.	Zinc	102-104	serotransferrin	Bos taurus	11-22
28677078-1	2017	Bovine apo-transferrin (Tf) dose-dependently inhibited zinc (Zn) measurement if apo-Tf was added to a Zn standard solution followed by Zn measurement using a commercial Zn assay kit.	Zinc	102-104	serotransferrin	Bos taurus	11-22
28548590-8	2017	For Zn, the lowest exposure tertile compared with the highest tertile was associated with 1.26 percent increase in NR3C1 methylation (P=0.01).	Zinc	4-6	nuclear receptor subfamily 3 group C member 1	Homo sapiens	115-120
28532099-0	2017	Interaction of insulin with colloidal ZnS quantum dots functionalized by various surface capping agents.	Zinc	38-41	insulin	Homo sapiens	15-22
28532099-3	2017	In this regard, in the present work, the interaction between the insulin and differently functionalized ZnS quantum dots (QDs) were studied.	Zinc	104-107	insulin	Homo sapiens	65-72
28532099-6	2017	The interaction between insulin and the ZnS QDs were investigated by fluorescence quenching, synchronous fluorescence, circular dichroism (CD), and thermal aggregation techniques.	Zinc	40-43	insulin	Homo sapiens	24-31
28753623-5	2017	This betabetaalphabeta core largely defines the overall fold of the TRIM21 B-box2 and the coordination of one Zn2+ ion stabilizes the tertiary structure of the protein.	Zinc	110-114	tripartite motif containing 21	Homo sapiens	68-74
28653849-4	2017	After two rounds of structural optimization, these design approaches led to small molecule MMP-13 inhibitors 10d and (S)-17b, which bind within the substrate-binding site of MMP-13 and surround the catalytically active Zn2+ ion without chelating to the metal.	Zinc	219-223	matrix metallopeptidase 13	Homo sapiens	91-97
28742830-11	2017	Zn induced a reduction of Cd-induced MT-1s expression, in particular of MT-1X (3-fold), and subsequently the final intra-cellular content of Cd.	Zinc	0-2	metallothionein 1A	Homo sapiens	37-42
28742830-11	2017	Zn induced a reduction of Cd-induced MT-1s expression, in particular of MT-1X (3-fold), and subsequently the final intra-cellular content of Cd.	Zinc	0-2	metallothionein 1X	Homo sapiens	72-77
28742830-12	2017	By reducing Cd accumulation in cells, Zn reversed Cd anti-proliferative and anti-inflammatory effects but preserved the low MMP-3/TIMP-1 ratio induced by Cd, which was enhanced by inflammatory conditions.	Zinc	38-40	matrix metallopeptidase 3	Homo sapiens	124-129
28742830-12	2017	By reducing Cd accumulation in cells, Zn reversed Cd anti-proliferative and anti-inflammatory effects but preserved the low MMP-3/TIMP-1 ratio induced by Cd, which was enhanced by inflammatory conditions.	Zinc	38-40	TIMP metallopeptidase inhibitor 1	Homo sapiens	130-136
28537317-5	2017	The detection limits of Zn2+ and Cu2+ were 5.59 muM and 0.148 muM, respectively, with APBHN, which are lower than the WHO guidelines (76 muM for Zn2+ and 31.5 muM for Cu2+) for drinking water.	Zinc	24-28	latexin	Homo sapiens	48-51
28495383-3	2017	In the presented work, a Zn(II) complex of cyclen substituted with two l-tryptophan units, Zn(II)-Cyclen-(Trp)2 has been synthesized and evaluated for antiproliferative activity.	Zinc	25-31	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	91-111
27476997-0	2017	Synthesis and crystal structures of cobalt(II), cadmium(II), and zinc(II) complexes of 4-nitro phenylcyanamide: enhancing the biological properties through bound to human serum albumin.	Zinc	65-73	albumin	Homo sapiens	171-184
28686686-9	2017	Zn2+ induced expression of HIF1alpha and HIF2alpha but not HIF3alpha in HK-2 and ACHN cells.	Zinc	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-36
28892882-6	2017	RESULTS: Significant higher plasma levels of protein carbonyls and oxidant/antioxidants ratio (protein carbonyls/{SOD+GPx}) with significant lower plasma levels of Zn, Cu, Se, erythrocyte SOD and GPx activities were found in the preterms with RDS when compared with the preterms without RDS (p&lt;0.001 for all measured markers for both groups).	Zinc	164-166	superoxide dismutase 1	Homo sapiens	114-117
28892882-6	2017	RESULTS: Significant higher plasma levels of protein carbonyls and oxidant/antioxidants ratio (protein carbonyls/{SOD+GPx}) with significant lower plasma levels of Zn, Cu, Se, erythrocyte SOD and GPx activities were found in the preterms with RDS when compared with the preterms without RDS (p&lt;0.001 for all measured markers for both groups).	Zinc	164-166	superoxide dismutase 1	Homo sapiens	188-191
28527712-5	2017	It is well-known that Zn2+ ions coordinate and stabilize the hexameric forms of insulin.	Zinc	22-26	insulin	Homo sapiens	80-87
28595785-6	2017	Zn NPs showed dual effects, as its middle dose played protective role and recovered cardiac damages evidenced by significant reduction of serum cholesterol, HDL-cholesterol, lipoprotein (a), atherogenic index, TNF-alpha, cardiac MDA, B-type natriuretic peptide and caspase-3 activity.	Zinc	0-2	tumor necrosis factor	Rattus norvegicus	210-219
28537317-5	2017	The detection limits of Zn2+ and Cu2+ were 5.59 muM and 0.148 muM, respectively, with APBHN, which are lower than the WHO guidelines (76 muM for Zn2+ and 31.5 muM for Cu2+) for drinking water.	Zinc	24-28	latexin	Homo sapiens	62-65
28537317-5	2017	The detection limits of Zn2+ and Cu2+ were 5.59 muM and 0.148 muM, respectively, with APBHN, which are lower than the WHO guidelines (76 muM for Zn2+ and 31.5 muM for Cu2+) for drinking water.	Zinc	24-28	latexin	Homo sapiens	62-65
28537317-5	2017	The detection limits of Zn2+ and Cu2+ were 5.59 muM and 0.148 muM, respectively, with APBHN, which are lower than the WHO guidelines (76 muM for Zn2+ and 31.5 muM for Cu2+) for drinking water.	Zinc	24-28	latexin	Homo sapiens	62-65
28621407-5	2017	The limit of quantification for both Zn and Cu was 5 mug L-1 and 10 mug L-1 for Fe and the recovery for Zn, Fe and Cu was ranged from 90% to 94%, 97% to 103% and 90% to 102%, respectively.	Zinc	37-39	L1 cell adhesion molecule	Homo sapiens	57-75
28321933-0	2017	Exploring the cause of aggregation and reduced Zn binding affinity by G85R mutation in SOD1 rendering amyotrophic lateral sclerosis.	Zinc	47-49	superoxide dismutase 1	Homo sapiens	87-91
28321933-2	2017	ALS occurs due to various notably prominent missense mutations, in gene encoding Cu-Zn superoxide dismutase (SOD1) thereby leading to aggregation, dysfunction and reduced Zn binding affinity.	Zinc	84-86	superoxide dismutase 1	Homo sapiens	109-113
28621407-6	2017	Mean concentrations of Zn, Fe, and Cu in human milk samples were 5.35, 0.47 and 0.83 mg L-1, respectively while these values in infant formula were ranged from 3.52-4.75 mg L-1, 3.37-4.56 mg L-1 and 0.28-0.41 mg L-1, respectively.	Zinc	23-25	L1 cell adhesion molecule	Homo sapiens	88-91
28303360-5	2017	To clarify the interplay between LA and metal ion binding to HSA, the dependence of LA binding to HSA on Zn2+, Cu2+, Mg2+ and Ca2+ levels and structural consequences of these interactions have been explored.	Zinc	105-109	albumin	Homo sapiens	98-101
28303360-7	2017	Zn2+ binding to HSA causes a loss of one bound LA molecule, while the other metals studied exert an opposite effect (1-2 extra LA molecules are bound).	Zinc	0-4	albumin	Homo sapiens	16-19
28303360-9	2017	However, the Zn2+-induced decline in LA capacity of HSA could be due to accumulation of multimeric HSA forms.	Zinc	13-17	albumin	Homo sapiens	52-55
28303360-9	2017	However, the Zn2+-induced decline in LA capacity of HSA could be due to accumulation of multimeric HSA forms.	Zinc	13-17	albumin	Homo sapiens	99-102
28303360-10	2017	Opposite to Ca2+/Mg2+-binding, Zn2+ or Cu2+ association with HSA induces marked changes in its hydrophobic surface.	Zinc	31-35	albumin	Homo sapiens	61-64
28303360-13	2017	Zn2+ and Cu2+ induce more pronounced changes in hydrophobic surface and quaternary structure of HSA and its LA capacity.	Zinc	0-4	albumin	Homo sapiens	96-99
26096753-1	2017	OBJECTIVE: To determine serum zinc (Zn) level among cystic fibrosis (CF) patients with homozygous CFTR I1234V mutation associated with pancreatic sufficiency (PS).	Zinc	36-38	CF transmembrane conductance regulator	Homo sapiens	98-102
28363565-5	2017	Spherical Zn-CNP (diameter 250-300nm) were positively charged (zeta potential, +42.34mV) and contained ~20mg Zn/g (w/w).	Zinc	10-12	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	13-16
28112064-4	2017	In animal models linear growth is particularly sensitive to dietary protein as well as Zn intake, which act through insulin, insulin-like growth factor-1 (IGF-1) and its binding proteins, triiodothyronine, amino acids and Zn2+ to stimulate growth-plate protein and proteoglycan synthesis and cell cycle progression, actions which are blocked by corticosteroids and inflammatory cytokines.	Zinc	87-89	insulin	Homo sapiens	116-123
28112064-4	2017	In animal models linear growth is particularly sensitive to dietary protein as well as Zn intake, which act through insulin, insulin-like growth factor-1 (IGF-1) and its binding proteins, triiodothyronine, amino acids and Zn2+ to stimulate growth-plate protein and proteoglycan synthesis and cell cycle progression, actions which are blocked by corticosteroids and inflammatory cytokines.	Zinc	87-89	insulin like growth factor 1	Homo sapiens	125-153
28112064-4	2017	In animal models linear growth is particularly sensitive to dietary protein as well as Zn intake, which act through insulin, insulin-like growth factor-1 (IGF-1) and its binding proteins, triiodothyronine, amino acids and Zn2+ to stimulate growth-plate protein and proteoglycan synthesis and cell cycle progression, actions which are blocked by corticosteroids and inflammatory cytokines.	Zinc	87-89	insulin like growth factor 1	Homo sapiens	155-160
28390480-4	2017	A NOBIAS Chelate-PA1 resin column was used to quantitatively collect Ni, Cu, and Zn from seawater and thoroughly remove the seawater matrix.	Zinc	81-83	PAXIP1 associated glutamate rich protein 1	Homo sapiens	17-20
26096753-7	2017	Seven (13.2%) patients with CFTR I1234V and PS had low Zn levels (&lt;0.6 mcg/mL).	Zinc	55-57	CF transmembrane conductance regulator	Homo sapiens	28-32
28366235-5	2017	RESULTS: Free Zn ions (0-5ppm) enhanced proliferation and alkaline phosphatase (ALP) activity of hDPSCs.	Zinc	14-16	alkaline phosphatase, placental	Homo sapiens	58-78
28366235-5	2017	RESULTS: Free Zn ions (0-5ppm) enhanced proliferation and alkaline phosphatase (ALP) activity of hDPSCs.	Zinc	14-16	alkaline phosphatase, placental	Homo sapiens	80-83
31994098-4	2017	HO-1 immunocontents were evaluated in the prefrontal cortex and hippocampus 60 min after ZnCl2 (10 mg/kg, po) treatment.	Zinc	89-94	heme oxygenase 1	Mus musculus	0-4
28390674-10	2017	In addition, expression of caspase 9 was lower in Cd2+ (5 mumol/L)-treated PC12 cells when co-treated with Zn2+ (2 and 5 mumol/L).	Zinc	107-111	caspase 9	Rattus norvegicus	27-36
28552173-5	2017	In THP-1 macrophage cell line and in human primary macrophages, Zn2+ at sub-toxic doses (30 muM) caused stimulation of TNF-alpha and IL-10 with different dynamics reaching the maximum peak at the zinc concentration 100 muM, before the cell death.	Zinc	64-68	tumor necrosis factor	Homo sapiens	119-128
28552173-7	2017	Similar effects on cell viability were obtained also in C6 astrocytes, where Zn2+ slightly increased the nitric oxide release only in cells activated by one of the pro-inflammatory stimuli used in our cellular model (interferon gamma plus TNF-alpha).	Zinc	77-81	tumor necrosis factor	Homo sapiens	239-248
26995406-7	2017	NO donors also salvage from Zn-induced increase in lipid peroxidation (LPO), mitochondrial cytochrome c release, and caspase-3 activation.	Zinc	28-30	cytochrome c, somatic	Homo sapiens	91-103
26995406-7	2017	NO donors also salvage from Zn-induced increase in lipid peroxidation (LPO), mitochondrial cytochrome c release, and caspase-3 activation.	Zinc	28-30	caspase 3	Homo sapiens	117-126
28232492-0	2017	Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.	Zinc	64-68	solute carrier family 30 member 7	Rattus norvegicus	42-46
28232492-2	2017	We hypothesized that ZIP7 and ZnT7 transport Zn2+ in opposing directions across the S(E)R membrane in cardiomyocytes and that changes in their activity play an important role in the development of ER stress during hyperglycemia.	Zinc	45-49	solute carrier family 30 member 7	Rattus norvegicus	30-34
28232492-8	2017	We conclude that subcellular free Zn2+ redistribution in the hyperglycemic heart, resulting from altered ZIP7 and ZnT7 activity, contributes to cardiac dysfunction in diabetes.	Zinc	34-38	solute carrier family 30 member 7	Rattus norvegicus	114-118
28378589-0	2017	Kinetic Insights into Zn2+-Induced Amyloid beta-Protein Aggregation Revealed by Stopped-Flow Fluorescence Spectroscopy.	Zinc	22-26	amyloid beta precursor protein	Homo sapiens	35-47
28378589-1	2017	Zn2+ has remarkable impacts on amyloid beta-protein (Abeta) aggregation, which is crucial in the pathology of Alzheimer"s disease.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	53-58
31994098-8	2017	ZnCl2 administration increased HO-1 immunocontents only in the prefrontal cortex.	Zinc	0-5	heme oxygenase 1	Mus musculus	31-35
28378589-3	2017	It is difficult to explore the details of the interaction between Zn2+ and Abeta within such a short time scale by using ordinary analytical methods.	Zinc	66-70	amyloid beta precursor protein	Homo sapiens	75-80
31994098-9	2017	CONCLUSIONS: The results indicate that the antidepressant-like effect of ZnCl2 in the TST may depend on the induction of HO-1, and activation of TrkB receptor.	Zinc	73-78	heme oxygenase 1	Mus musculus	121-125
28378589-11	2017	The findings demonstrate the significant effect of Zn2+ on Abeta aggregation and provide new insight into its mechanisms.	Zinc	51-55	amyloid beta precursor protein	Homo sapiens	59-64
28469631-10	2017	Yeast complementation tests indicated that PtIRT1, PtZIP1, PtZIP2, PtZIP3, and PtZIP12 were able to complement the zrt1zrt2 mutant, which was deficient in Zn uptake; PtIRT1 and PtZIP7 were able to complement the fet3fet4 mutant, which was deficient in Fe uptake, and PtIRT1 was able to complement the smf1 mutant, which was deficient in Mn uptake, suggesting their respective functions in Zn, Fe, and Mn transport.	Zinc	389-391	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	115-123
28436418-1	2017	Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1-3 have been synthesized and fully characterized.	Zinc	42-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
28427190-4	2017	Pygopus2 (Pygo2), which contains a Zn-coordinated plant homeodomain (PHD) finger domain, is critical for beta-catenin-dependent transcriptional switches in normal and malignant tissues and is over-expressed in various cancers, including human brain glioma.	Zinc	35-37	pygopus family PHD finger 2	Homo sapiens	0-8
28427190-4	2017	Pygopus2 (Pygo2), which contains a Zn-coordinated plant homeodomain (PHD) finger domain, is critical for beta-catenin-dependent transcriptional switches in normal and malignant tissues and is over-expressed in various cancers, including human brain glioma.	Zinc	35-37	pygopus family PHD finger 2	Homo sapiens	10-15
28469631-10	2017	Yeast complementation tests indicated that PtIRT1, PtZIP1, PtZIP2, PtZIP3, and PtZIP12 were able to complement the zrt1zrt2 mutant, which was deficient in Zn uptake; PtIRT1 and PtZIP7 were able to complement the fet3fet4 mutant, which was deficient in Fe uptake, and PtIRT1 was able to complement the smf1 mutant, which was deficient in Mn uptake, suggesting their respective functions in Zn, Fe, and Mn transport.	Zinc	155-157	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	115-123
27225690-8	2017	Possession of common risk alleles at the SLC30A8 locus, encoding the beta-cell granule zinc transporter ZnT8, may affect cytosolic Zn2+ concentrations and thus susceptibility to hypoxia and oxidative stress.	Zinc	131-135	solute carrier family 30 member 8	Homo sapiens	41-48
28174029-7	2017	We concluded that a diet with a pharmacological dose of Zn increased the accumulation of Zn and the expression of Bax, cleaved caspase-3, and caspase-8, which might activate the apoptosis and lead to the marked injury of porcine small intestinal epithelium.	Zinc	56-58	caspase 8	Sus scrofa	142-151
28334855-11	2017	Cytosolic Zn2+ measurements in HEK293 cells overexpressing wild-type and mutant SLC30A9 showed lower zinc concentration within mutant rather than wild-type SLC30A9 cells.	Zinc	10-14	solute carrier family 30 member 9	Homo sapiens	80-87
28334855-11	2017	Cytosolic Zn2+ measurements in HEK293 cells overexpressing wild-type and mutant SLC30A9 showed lower zinc concentration within mutant rather than wild-type SLC30A9 cells.	Zinc	10-14	solute carrier family 30 member 9	Homo sapiens	156-163
27225690-8	2017	Possession of common risk alleles at the SLC30A8 locus, encoding the beta-cell granule zinc transporter ZnT8, may affect cytosolic Zn2+ concentrations and thus susceptibility to hypoxia and oxidative stress.	Zinc	131-135	solute carrier family 30 member 8	Homo sapiens	104-108
28043033-7	2017	In particular, with the elevated Zn concentrations in mixtures, the TD model showed better predictive power in predicting toxicity of 10-6M Cu concentration in Cu-Zn mixtures.	Zinc	33-35	superoxide dismutase 1, soluble	Danio rerio	160-165
27487980-0	2017	Zn-biofortification enhanced nitrogen metabolism and photorespiration process in green leafy vegetable Lactuca sativa L. BACKGROUND: Excessive rates of nitrogen (N) fertilizers may result in elevated concentrations of nitrate (NO3- ) in plants.	Zinc	0-2	NBL1, DAN family BMP antagonist	Homo sapiens	227-230
27487980-2	2017	The main objective of the present study was to determine whether the NO3- accumulation and the nitrogen use efficiency was affected by the application of different doses of Zn in Lactuca sativa plants.	Zinc	173-175	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
27487980-3	2017	RESULTS: Zn doses in the range 80-100 micromol L-1 produced an increase in Zn concentration provoking a decrease of NO3- concentration and increase of the nitrate reductase, glutamine synthetase and aspartate aminotransferase activities, as well as the photorespiration processes.	Zinc	9-11	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
27487980-3	2017	RESULTS: Zn doses in the range 80-100 micromol L-1 produced an increase in Zn concentration provoking a decrease of NO3- concentration and increase of the nitrate reductase, glutamine synthetase and aspartate aminotransferase activities, as well as the photorespiration processes.	Zinc	75-77	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
27487980-6	2017	CONCLUSION: Adequate Zn fertilization is an important critical player in lettuce, especially at a dose of 80 micromol L-1 of Zn, because it could result in an increase in the Zn concentration, a reduction of NO3- levels and an increase the concentration of essential amino acids, with all of them having beneficial properties for the human diet.	Zinc	21-23	NBL1, DAN family BMP antagonist	Homo sapiens	208-211
28194465-4	2017	The deletion of CKA2, the yeast orthologue of mammalian CK2alpha", leads to a pronounced resistant phenotype against Zn2+ and Al3+, whilst the deletion of CKB1 or CKB2 results in tolerance to Cr6+ and As3+.	Zinc	117-121	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	16-20
28271284-0	2017	A theoretical study on Zn binding loop mutants instigating destabilization and metal binding loss in human SOD1 protein.	Zinc	23-25	superoxide dismutase 1	Homo sapiens	107-111
28271284-4	2017	In the present study, we explored the effect of mutations on the mechanistic action on the Zn binding loop of SOD1 through discrete molecular dynamics.	Zinc	91-93	superoxide dismutase 1	Homo sapiens	110-114
28091657-4	2017	Since its cloning in 1995, ZnT-1 is considered a major extruder of Zn2+ based on its capability to protect cells against zinc toxicity.	Zinc	67-71	solute carrier family 30 member 1	Homo sapiens	27-32
28091657-5	2017	Recently, we reported that ZnT-1 inhibits the L-type calcium channel (LTCC), a major Zn2+ and Ca2+ entry pathway.	Zinc	85-89	solute carrier family 30 member 1	Homo sapiens	27-32
28091657-6	2017	Here we show that ZnT-1 is a dual-function protein by demonstrating that its abilities to exchange Zn2+/H+ and to inhibit the LTCC are independent of each other and are mediated by different parts of the protein.	Zinc	99-103	solute carrier family 30 member 1	Homo sapiens	18-23
28322340-3	2017	H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ34, a PARP inhibitor, and abolished by TRPM2 knockout (TRPM2-KO).	Zinc	5-9	poly(ADP-ribose) polymerase 1	Homo sapiens	126-130
28322340-4	2017	Pathological concentrations of H2O2/Zn2+ induced substantial cell death that was inhibited by PJ34 and DPQ, PARP inhibitors, 2-APB, a TRPM2 channel inhibitor, and prevented by TRPM2-KO.	Zinc	36-40	poly(ADP-ribose) polymerase 1	Homo sapiens	108-112
28322340-5	2017	Further analysis indicate that Zn2+ induced ROS production, PARP-1 stimulation, increase in the [Ca2+]c and cell death, all of which were suppressed by chelerythrine, a protein kinase C inhibitor, DPI, a NADPH-dependent oxidase (NOX) inhibitor, GKT137831, a NOX1/4 inhibitor, and Phox-I2, a NOX2 inhibitor.	Zinc	31-35	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
28322340-6	2017	Furthermore, Zn2+-induced PARP-1 stimulation, increase in the [Ca2+]c and cell death were inhibited by PF431396, a Ca2+-sensitive PYK2 inhibitor, and U0126, a MEK/ERK inhibitor.	Zinc	13-17	poly(ADP-ribose) polymerase 1	Homo sapiens	26-32
28322340-6	2017	Furthermore, Zn2+-induced PARP-1 stimulation, increase in the [Ca2+]c and cell death were inhibited by PF431396, a Ca2+-sensitive PYK2 inhibitor, and U0126, a MEK/ERK inhibitor.	Zinc	13-17	mitogen-activated protein kinase kinase 7	Homo sapiens	159-162
28322340-6	2017	Furthermore, Zn2+-induced PARP-1 stimulation, increase in the [Ca2+]c and cell death were inhibited by PF431396, a Ca2+-sensitive PYK2 inhibitor, and U0126, a MEK/ERK inhibitor.	Zinc	13-17	mitogen-activated protein kinase 1	Homo sapiens	163-166
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	poly(ADP-ribose) polymerase 1	Homo sapiens	68-74
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	mitogen-activated protein kinase kinase 7	Homo sapiens	217-220
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	mitogen-activated protein kinase 1	Homo sapiens	221-224
28194465-7	2017	Two contrasting findings were obtained for the CKA2 deletion mutant (cka2Delta) against Al3+ or Zn2+.	Zinc	96-100	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	47-51
27881214-4	2017	Interestingly, we found that Zn2+ promotes transduction effects of recombinant human SOD3 (rhSOD3) by increasing uptake via the heparin binding domain (HBD).	Zinc	29-33	superoxide dismutase 3	Homo sapiens	85-89
28302075-15	2017	Nevertheless, there was a significant correlation between MTT (MTT1/MTT0) and eGFR (eGFR1/eGFR0) in case of Zn administration (rho = -0.49; 95%-CI: -0.78 to -0.03; p = 0.04).	Zinc	108-110	epidermal growth factor receptor	Homo sapiens	78-82
28302075-18	2017	However, there was a significant negative correlation between MTT and eGFR in vivo in case of Zn administration, this could indicate a protective role of MTTs in a setting of reduced kidney function, which is possibly influenced by Zn.	Zinc	94-96	epidermal growth factor receptor	Homo sapiens	70-74
28096459-5	2017	We found that Zn2+ induces APP-C99 dimerization, which prevents its cleavage by gamma-secretase and Abeta production, with an IC50 value of 15 mum Importantly, at this concentration, Zn2+ also drastically raised the production of the aggregation-prone Abeta43 found in the senile plaques of AD brains and elevated the Abeta43:Abeta40 ratio, a promising biomarker for neurotoxicity and AD.	Zinc	14-18	amyloid beta precursor protein	Homo sapiens	100-105
28096459-5	2017	We found that Zn2+ induces APP-C99 dimerization, which prevents its cleavage by gamma-secretase and Abeta production, with an IC50 value of 15 mum Importantly, at this concentration, Zn2+ also drastically raised the production of the aggregation-prone Abeta43 found in the senile plaques of AD brains and elevated the Abeta43:Abeta40 ratio, a promising biomarker for neurotoxicity and AD.	Zinc	183-187	amyloid beta precursor protein	Homo sapiens	100-105
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Zinc	97-101	amyloid beta precursor protein	Homo sapiens	151-156
28096459-6	2017	We further demonstrate that the APP-C99 histidine residues His-6, His-13, and His-14 control the Zn2+-dependent APP-C99 dimerization and inhibition of Abeta production, whereas the increased Abeta43:Abeta40 ratio is substrate dimerization-independent and involves the known Zn2+ binding lysine Lys-28 residue that orientates the APP-C99 transmembrane domain within the lipid bilayer.	Zinc	274-278	amyloid beta precursor protein	Homo sapiens	151-156
28231533-3	2017	The results indicate that Co(II), Ni(II) and Zn(II) complexes possess tetrahedral geometry while Cu(II) complex exhibits square planar structure.	Zinc	45-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
28124054-4	2017	The highest level of Zn (&gt;20 mug g-1) was found in mossy fiber-rich regions - cornu ammonis field 4 (CA4), gyrus dentatus, and CA3.	Zinc	21-23	carbonic anhydrase 3	Homo sapiens	130-133
27881214-6	2017	This resulted in increased inhibitory effects of rhSOD3 on NF-kB and STAT3 signals in the presence of Zn2+, which shows elevated association of rhSOD3 into the cells.	Zinc	102-106	signal transducer and activator of transcription 3	Homo sapiens	69-74
28209516-4	2017	A beta-hairpin in the third Zn-binding module (Zn3hp) of UvrA has been suggested to undergo a conformational change upon DNA binding, and proposed to be important for damage sensing.	Zinc	28-30	amyloid beta precursor protein	Homo sapiens	0-6
28199205-5	2017	In addition to zinc transporters (ZnT) of the solute-carrier family type 30A (SLC30A), the lysosomal ion channel TRPML1 and the poorly understood novel transporter TMEM163 have been shown to play a role in the Zn2+ uptake by the lysosomes.	Zinc	210-214	mucolipin TRP cation channel 1	Homo sapiens	113-119
28204942-4	2017	In agreement with the clinical tests performed on the C203Y patient, protein modeling and molecular dynamics suggest that direct interactions with RIPK2 and Caspase3 are altered by the C203Y mutation and subsequent loss of Zn coordination in the second BIR domain of XIAP.	Zinc	223-225	caspase 3	Homo sapiens	157-165
28192915-7	2017	The instrument is applicable for multielement analysis, and the LODs ranged from 0.16 to 11.65 mug L-1 for Zn, Pb, Ag, Cd, Au, Cu, Mn, Fe, Cr, and As.	Zinc	107-109	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
28232787-5	2017	The co-administration of Cu2+ and Zn2+ also significantly increased the expression of genes related to the endoplasmic reticulum"s stress response, including CHOP, GADD34, and ATF4.	Zinc	34-38	activating transcription factor 4	Mus musculus	176-180
27915020-3	2017	The Zn/Mg-PIII surfaces were found to promote initial adhesion and spreading of rat bone marrow mesenchymal stem cells (rBMSCs) via the upregulation of the gene expression of integrin alpha1 and integrin beta1.	Zinc	4-6	integrin subunit beta 1	Rattus norvegicus	195-209
27915020-4	2017	More importantly, it was revealed that Zn/Mg-PIII could increase Zn2+ and Mg2+ concentrations in rBMSCs by promoting the influx of Zn2+ and Mg2+ and inhibiting the outflow of Zn2+, and then could enhance the transcription of Runx2 and the expression of ALP and OCN.	Zinc	39-41	RUNX family transcription factor 2	Homo sapiens	225-230
27915020-4	2017	More importantly, it was revealed that Zn/Mg-PIII could increase Zn2+ and Mg2+ concentrations in rBMSCs by promoting the influx of Zn2+ and Mg2+ and inhibiting the outflow of Zn2+, and then could enhance the transcription of Runx2 and the expression of ALP and OCN.	Zinc	39-41	bone gamma-carboxyglutamate protein	Homo sapiens	261-264
27915020-5	2017	Meanwhile, Mg2+ ions from Zn/Mg-PIII increased Mg2+ influx by upregulating the expression of MagT1 transporter in human umbilical vein endothelial cells (HUVECs), and then stimulated the transcription of VEGF and KDR via activation of hypoxia inducing factor (HIF)-1alpha, thus inducing angiogenesis.	Zinc	26-28	vascular endothelial growth factor A	Homo sapiens	204-208
27915020-5	2017	Meanwhile, Mg2+ ions from Zn/Mg-PIII increased Mg2+ influx by upregulating the expression of MagT1 transporter in human umbilical vein endothelial cells (HUVECs), and then stimulated the transcription of VEGF and KDR via activation of hypoxia inducing factor (HIF)-1alpha, thus inducing angiogenesis.	Zinc	26-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-271
28100752-9	2017	The present study of events during and after acute oxygen glucose deprivation highlights a possible important difference, with rapid synaptic entry of Ca2+ and Zn2+ contributing more in CA3, but with delayed and long-lasting accumulation of Zn2+ within mitochondria occurring in CA1 but not CA3 pyramidal neurons.	Zinc	160-164	carbonic anhydrase 3	Mus musculus	186-189
28011267-2	2017	Besides other mechanisms, here we have explored the important role of Zn and Zn-dependent SOD1in methotrexate (MTX)-induced germ cell damage.	Zinc	77-79	superoxide dismutase 1	Rattus norvegicus	90-94
28100752-0	2017	Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria.	Zinc	115-119	carbonic anhydrase 3	Mus musculus	41-44
28228867-8	2016	By retaining force constant change parameter of 14NSe (15NSe) in heavily N-doped ZnSe, the ATM-GF theory predicted (a) three non-degenerate LVMs for the photoluminescence defect center VSe-Zn-14NSe (VSe-Zn-15NSe) of Cs symmetry, and (b) six impurity modes for the second nearest-neighbor NSe-Zn-NSe pair defect of C2v symmetry.	Zinc	81-83	enolase 2	Homo sapiens	57-60
28100752-4	2017	Using mouse hippocampal slices to study acute oxygen glucose deprivation (OGD)-triggered neurodegeneration, we found evidence for early contributions of excitotoxic Ca2+ and Zn2+ accumulation in both CA1 and CA3, as indicated by the ability of Zn2+ chelators or Ca2+ entry blockers to delay pyramidal neuronal death in both regions.	Zinc	244-248	carbonic anhydrase 2	Mus musculus	165-168
28100752-7	2017	Furthermore, the recovery appeared to be accompanied by mitochondrial Zn2+ accumulation (via the mitochondrial Ca2+ uniporter MCU) in CA1 but not in CA3 neurons and was markedly diminished in MT-III knock-outs, suggesting that it depended upon Zn2+ mobilization from this protein.	Zinc	70-74	carbonic anhydrase 2	Mus musculus	111-114
27260533-10	2017	ALP activity was also increased with elevated Zn2+ concentrations and extended culture periods, but enhanced matrix nodules formation were observed only in 4 x 10-5 and 8 x 10-5 M Zn2+ groups.	Zinc	46-50	alkaline phosphatase, placental	Homo sapiens	0-3
27746360-7	2017	In contrast, the significantly higher, yet non-cytotoxic, Zn2+ ion concentration from the degradation of ZSr41D alloy was likely the cause for the initially higher VCAM-1 expression on cultured HUVECs.	Zinc	58-62	vascular cell adhesion molecule 1	Homo sapiens	164-170
27541797-8	2017	On the basis of the spectral studies, TGA and DFT data an octahedral geometry has been assigned for Co(II), Ni(II), square planar for Cu(II) and tetrahedral for Zn(II) complexes.	Zinc	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-106
28049831-4	2017	Zn2+ accumulation in amacrine cell processes involves the Zn2+ transporter protein ZnT-3, and deletion of slc30a3, the gene encoding ZnT-3, promotes RGC survival and axon regeneration.	Zinc	0-4	solute carrier family 30 member 3	Homo sapiens	83-88
27885434-9	2017	The expression levels of miR-21, miR-31, miR-93 and miR-375 were different when Zn levels were varied in EC cell lines, but only miR-21 and miR-375 were associated with patient characteristics and prognosis in patients with EC from an area of China with a high incidence of EC.	Zinc	80-82	microRNA 375	Homo sapiens	52-59
28013473-13	2017	In the industrial region, alkaline phosphatase activity had significant negative correlations with total Cu, Pb, Cr, Zn, Cd, and heavy metal fractions.	Zinc	117-119	alkaline phosphatase, placental	Homo sapiens	26-46
27983650-13	2016	Hydrophobic effect of VAL518 and electrostatic effects of HIS383, HIS387, HIS513 and Zn2+ were also regarded as playing a key role in inhibiting ACE activities.	Zinc	85-89	angiotensin I converting enzyme	Homo sapiens	145-148
27654922-4	2016	In particular, treatment of human glioblastoma cells with sublethal doses of cell-permeable heavy metal (Zn2+ &gt; Fe2+ &gt; Mn2+) chelator (N,N,N",N"-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN)) induced ZIP9 expression.	Zinc	105-109	solute carrier family 39 member 9	Homo sapiens	209-213
27942001-2	2016	In this context, we showed that human VEGFR1 domain 2 crystallizes in the presence of Zn2+, Co2+ or Cu2+ as a dimer that forms via metal-ion interactions and interlocked hydrophobic surfaces.	Zinc	86-90	fms related receptor tyrosine kinase 1	Homo sapiens	38-44
27770658-6	2016	In addition, ZnO NPs dose-dependently increased intracellular Zn ions in THP-1 macrophages, which was not significantly affected by PA.	Zinc	13-15	GLI family zinc finger 2	Homo sapiens	73-78
27797597-11	2016	These results, which are the first report of the existence of Zn2+ signaling downstream of CCK2R activation, suggest that zinc chelation therapies may be effective in counteracting gastrin-dependent tumor growth.	Zinc	62-66	cholecystokinin B receptor	Homo sapiens	91-96
26660328-0	2016	Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies.	Zinc	37-39	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	60-66
26995290-4	2016	At mossy fiber-CA3 pyramidal cell synapses and Schaffer collateral-CA1 pyramidal cell synapses, which are zincergic, extracellular Zn2+ signaling leads to intracellular Zn2+ signaling and is involved in learning and memory.	Zinc	131-135	carbonic anhydrase 3	Homo sapiens	15-18
26660328-1	2016	Recent data has indicated that Zn can modulate serotonergic function through the 5-HT1A receptor (5-HT1AR); however, the exact mechanisms are unknown.	Zinc	31-33	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	81-96
26660328-1	2016	Recent data has indicated that Zn can modulate serotonergic function through the 5-HT1A receptor (5-HT1AR); however, the exact mechanisms are unknown.	Zinc	31-33	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	98-105
26660328-9	2016	However, in the FST performed with the 5-HT1A autoreceptor knockout mice, the anti-immobility effect of Zn was partially blocked.	Zinc	104-106	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	39-45
32263564-7	2016	Copper(ii), at concentrations as low as 5 muM, caused a strong quenching of both free and Zn2+ complexed dH3w.	Zinc	90-94	latexin	Homo sapiens	42-45
27662097-2	2016	The crystal structure of the host alpha-LiZnBO3 , which is both disordered and distorted with respect to Li and Zn occupancies and coordination geometries, is largely retained in the derivatives, which gives rise to unique colors (blue for CoII , magenta for NiII , violet for CuII ) that could be of significance for the development of new, inexpensive, and environmentally friendly pigment materials, particularly in the case of the blue pigments.	Zinc	42-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-244
27121973-3	2016	We investigated whether copper (Cu) and zinc (Zn) participated in the activation of HIF-1alpha in the process of hepatocarcinogenesis or not.	Zinc	46-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
27833104-4	2016	In this study, we determined the involvement of Zn-exporters, SLC30A 1-10 in PCa, in the context of racial health disparity in human PCa samples obtained from European-American (EA) and African-American (AA) populations.	Zinc	48-50	solute carrier family 30 member 1	Homo sapiens	62-70
27833104-7	2016	Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate.	Zinc	0-2	solute carrier family 30 member 1	Homo sapiens	109-116
27833104-7	2016	Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate.	Zinc	0-2	solute carrier family 30 member 9	Homo sapiens	118-125
27833104-7	2016	Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate.	Zinc	0-2	solute carrier family 30 member 10	Homo sapiens	130-138
27665863-1	2016	The Zn(II) ion has been linked to Alzheimer"s disease (AD) due to its ability to modulate the aggregating properties of the amyloid-beta (Abeta) peptide, where Abeta aggregation is a central event in the etiology of the disease.	Zinc	4-10	amyloid beta precursor protein	Homo sapiens	138-143
27665301-2	2016	Zinc (Zn) is important in a number of processes related to insulin secretion and insulin activity in peripheral tissues, making this element an interesting potential co-adjuvant in the treatment of patients with type 2 diabetes (T2D).	Zinc	6-8	insulin	Homo sapiens	59-88
27665301-6	2016	Furthermore, few studies examined the association between Zn status and insulin action and/or glucose homeostasis.	Zinc	58-60	insulin	Homo sapiens	72-79
27541153-5	2016	The average concentrations of Cr, Cu, Ni, Pb, and Zn in surface pore water were 18.8, 23.4, 12.0, 13.5, and 42.5 mug L-1, respectively.	Zinc	50-52	immunoglobulin kappa variable 1-16	Homo sapiens	117-120
27018170-2	2016	The authors tested if the bioavailability-normalized 5% hazardous concentration (HC5) estimated from chronic planktonic single-species toxicity data (HC5plankton ) for zinc (Zn) is protective for a plankton community and investigated the direct and indirect effects of Zn (at HC5 and HC50) on a freshwater community"s structure and function.	Zinc	174-176	CYCS pseudogene 1	Homo sapiens	81-84
27018170-2	2016	The authors tested if the bioavailability-normalized 5% hazardous concentration (HC5) estimated from chronic planktonic single-species toxicity data (HC5plankton ) for zinc (Zn) is protective for a plankton community and investigated the direct and indirect effects of Zn (at HC5 and HC50) on a freshwater community"s structure and function.	Zinc	174-176	CYCS pseudogene 1	Homo sapiens	150-153
27018170-2	2016	The authors tested if the bioavailability-normalized 5% hazardous concentration (HC5) estimated from chronic planktonic single-species toxicity data (HC5plankton ) for zinc (Zn) is protective for a plankton community and investigated the direct and indirect effects of Zn (at HC5 and HC50) on a freshwater community"s structure and function.	Zinc	269-271	CYCS pseudogene 1	Homo sapiens	81-84
28335323-3	2016	It was found that Zn from the brass substrates is the key factor in the formation of nanowires by restricting the lateral growth of InN.	Zinc	18-20	growth hormone releasing hormone	Homo sapiens	132-135
27811086-6	2016	In the wild type, their expression depended on combinations of low/high Zn and Cd concentrations; co-ordinated responses of NtZIP1, NtZIP2, and NtVTL were shown in medium containing 4 microM Cd, and at 0.5 microM versus 10 microM Zn.	Zinc	230-232	zinc transporter 5-like	Nicotiana tabacum	124-130
27811086-7	2016	In transgenics, qualitative changes detected for NtZIP1, NtZIP4, NtIRT1-like, and NtVTL are considered crucial for modification of Zn/Cd supply-dependent Zn/Cd root/shoot distribution.	Zinc	131-133	zinc transporter 5-like	Nicotiana tabacum	49-55
27811086-7	2016	In transgenics, qualitative changes detected for NtZIP1, NtZIP4, NtIRT1-like, and NtVTL are considered crucial for modification of Zn/Cd supply-dependent Zn/Cd root/shoot distribution.	Zinc	154-156	zinc transporter 5-like	Nicotiana tabacum	49-55
27665863-2	2016	Delineating Zn(II) binding properties to Abeta is thus a prerequisite to better grasp its potential role in AD.	Zinc	12-18	amyloid beta precursor protein	Homo sapiens	41-46
27665863-4	2016	To overcome these difficulties, we have investigated the impact of peptide alterations (mutations, N-terminal acetylation) on the Zn(Abeta) X-ray absorption spectroscopy fingerprint and on the Zn(II)-induced modifications of the Abeta peptides" NMR signatures.	Zinc	193-199	amyloid beta precursor protein	Homo sapiens	229-234
27394636-6	2016	The bioaccumulation factor (BAF) of Fe was highest followed by Zn and the lowest value was observed with Ni.	Zinc	63-65	BAF nuclear assembly factor 1	Homo sapiens	28-31
27764152-0	2016	Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family.	Zinc	53-57	S100 calcium binding protein A1	Homo sapiens	73-77
27764152-2	2016	Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.	Zinc	24-28	S100 calcium binding protein A1	Homo sapiens	5-9
27764152-6	2016	Using isothermal titration calorimetry, we found that Cu2+ and Zn2+ binding are common features of the family: the full breadth of human S100 paralogs-as well as two early-branching S100 proteins found in the tunicate Oikopleura dioica-bind these metals with muM affinity and stoichiometries ranging from 1:1 to 3:1 (metal:protein).	Zinc	63-67	S100 calcium binding protein A1	Homo sapiens	137-141
27764152-6	2016	Using isothermal titration calorimetry, we found that Cu2+ and Zn2+ binding are common features of the family: the full breadth of human S100 paralogs-as well as two early-branching S100 proteins found in the tunicate Oikopleura dioica-bind these metals with muM affinity and stoichiometries ranging from 1:1 to 3:1 (metal:protein).	Zinc	63-67	S100 calcium binding protein A1	Homo sapiens	182-186
27428851-6	2016	The as-synthesized 5-FU@FACS-Mn:ZnS nanoparticle (NP) systemically induced higher level of apoptosis in breast cancer cells in vitro as compared to cells treated with free 5-FU drug following both cell cycle and annexin assays, respectively.	Zinc	32-35	annexin A11, opposite strand	Mus musculus	212-219
27573342-2	2016	The binding and fluorescence sensing properties toward Cu2+ , Zn2+ , Cd2+ , and Pb2+ of L1 and receptor L2, composed of two [9]aneN3 macrocycles bridged by a 6,6""-dimethylen-2,2":6",2""-terpyridine unit, have been studied by coupling potentiometric, UV/Vis absorption, and emission measurements in aqueous media.	Zinc	62-66	L1 cell adhesion molecule	Homo sapiens	88-106
27711738-1	2016	The role of Cu and Zn ions in Alzheimer"s disease is linked to the consequences of their coordination to the amyloid-beta (Abeta) peptide, i.e. to the modulation of Abeta aggregation and to the production of Reactive Oxygen Species (ROS), two central events of the so-called amyloid cascade.	Zinc	19-21	amyloid beta precursor protein	Homo sapiens	109-121
27661257-2	2016	This Letter demonstrates, for the first time, an efficient method for the hexamerization of human insulin by a structure-specific triphenylmethane (TPM) dye, Ethyl Violet (EV), particularly, in the absence of Zn2+.	Zinc	209-213	insulin	Homo sapiens	98-105
27711738-1	2016	The role of Cu and Zn ions in Alzheimer"s disease is linked to the consequences of their coordination to the amyloid-beta (Abeta) peptide, i.e. to the modulation of Abeta aggregation and to the production of Reactive Oxygen Species (ROS), two central events of the so-called amyloid cascade.	Zinc	19-21	amyloid beta precursor protein	Homo sapiens	123-128
27711738-6	2016	We describe a proof-of-concept study where the role of Zn on the metal swap reaction between two prototypical ligands and the Cu(Abeta) species has been investigated by several complementary spectroscopic techniques (UV-Vis, EPR and XANES).	Zinc	55-57	amyloid beta precursor protein	Homo sapiens	129-134
27636564-5	2016	Moreover, alternating-current susceptibility measurements on these CoII complexes, magnetically diluted in their isostructural ZnII analogues, highlight the role of dipolar magnetic coupling in the mechanism of magnetization reversal.	Zinc	127-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
27567902-5	2016	The expression stabilities of ATP5B (ATP synthase) and CYC1 (subunits of the cytochrome) were the highest considering the effect of Zn and Cu treatments whereas SDHA (succinate dehydrogenase) was found to be the most unstable gene.	Zinc	132-134	ATP synthase F1 subunit beta	Homo sapiens	30-35
27567855-5	2016	Here, we study Cu(II) and Zn(II) interactions with Abeta bound to SDS micelles or to engineered aggregation-inhibiting molecules (the cyclic peptide CP-2 and the ZAbeta3(12-58)Y18L Affibody molecule).	Zinc	26-28	amyloid beta precursor protein	Homo sapiens	51-56
27567855-7	2016	In SDS micelles, Abeta was found to bind Cu(II) and Zn(II) with the same ligands and the same KD as in aqueous solution.	Zinc	52-58	amyloid beta precursor protein	Homo sapiens	17-22
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	16-18	thymoma viral proto-oncogene 1	Mus musculus	29-32
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	163-165	thymoma viral proto-oncogene 1	Mus musculus	29-32
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	163-165	thymoma viral proto-oncogene 1	Mus musculus	214-217
26956696-9	2016	Therefore, we concluded that Zn had an important anti-fibrosis role under HG/hypoxic conditions, and a novel mechanism contributing to Zn protection on renal tubular epithelial cells from HG/hypoxia-induced EMT through activation of PI3K/Akt/GSK-3beta signaling pathway, which subsequently leads to the downregulation of the expression of HIF-1alpha.	Zinc	29-31	thymoma viral proto-oncogene 1	Mus musculus	238-241
27567902-5	2016	The expression stabilities of ATP5B (ATP synthase) and CYC1 (subunits of the cytochrome) were the highest considering the effect of Zn and Cu treatments whereas SDHA (succinate dehydrogenase) was found to be the most unstable gene.	Zinc	132-134	cytochrome c1	Homo sapiens	55-59
27567443-5	2016	In addition, Zn deficient cells significantly triggered intracellular ROS level and develop oxidative stress induced DNA damage; it was confirmed by elevated expression of CYP1A, GPX, GSK3beta and TNF-alpha gene.	Zinc	13-15	tumor necrosis factor	Homo sapiens	197-206
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-63
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	tumor protein p53	Homo sapiens	76-79
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	cyclin dependent kinase inhibitor 2A	Homo sapiens	152-158
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	84-86	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	38-45
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	174-176	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	38-45
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	174-176	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	149-156
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	174-176	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	38-45
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	174-176	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	149-156
27385273-3	2016	Zn(2+) plus DA treatment-induced PC12 cell death was enhanced when there was over-expression of Gadd45b and was decreased by knock down of Gadd45b.	Zinc	0-2	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	96-103
27385273-3	2016	Zn(2+) plus DA treatment-induced PC12 cell death was enhanced when there was over-expression of Gadd45b and was decreased by knock down of Gadd45b.	Zinc	0-2	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	139-146
27385273-4	2016	MAPK p38 and JNK signaling was able to cross-talk with Gadd45b during Zn(2+) and DA treatment.	Zinc	70-72	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	55-62
27385273-5	2016	The synergistic effects of Zn(2+) and DA on PC12 cell death can be accounted for by an activation of the Gadd45b-induced cell death pathway and an inhibition of p38/JNK survival pathway.	Zinc	27-29	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	105-112
27521476-0	2016	Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.	Zinc	31-39	XPA, DNA damage recognition and repair factor	Homo sapiens	68-71
27521476-0	2016	Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.	Zinc	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	76-82
27521476-6	2016	Notably, XPAzf demonstrates comparable affinities for binding both metals, while PARP-1zf-1 shows a slightly higher affinity for Zn(II), suggesting that the relative concentrations of Zn(II) and As(III) in a system may significantly influence which species predominates in zinc finger occupancy.	Zinc	129-131	poly(ADP-ribose) polymerase 1	Homo sapiens	81-91
27521476-6	2016	Notably, XPAzf demonstrates comparable affinities for binding both metals, while PARP-1zf-1 shows a slightly higher affinity for Zn(II), suggesting that the relative concentrations of Zn(II) and As(III) in a system may significantly influence which species predominates in zinc finger occupancy.	Zinc	184-186	poly(ADP-ribose) polymerase 1	Homo sapiens	81-91
27385273-2	2016	By microarray analysis, we identified Gadd45b as a candidate molecule that mediates Zn(2+) and DA-induced cell death; the mRNA and protein levels of Gadd45b are increased by Zn(2+) treatment and raised to an even higher level by Zn(2+) plus DA treatment.	Zinc	84-86	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	149-156
27711752-0	2016	Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes.	Zinc	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
27501363-2	2016	Amyloid beta (Abeta) binds to and is aggregated by Zn2+ , a metal released from synaptic glutamatergic vesicles during neuronal activity.	Zinc	51-55	amyloid beta precursor protein	Homo sapiens	14-19
27501363-4	2016	We examined if Abeta, as a Zn2+ binding protein, regulates neuronal Zn2+ -signaling mediated by mZnR/GPR39 using SHSY-5Y cells and cortical neurons from GPR39 wild-type and knockout mice.	Zinc	27-31	amyloid beta precursor protein	Homo sapiens	15-20
27501363-6	2016	This impairment is overcome when excess Zn2+ is applied, suggesting that impaired Ca2+ -signaling results from Abeta binding of Zn2+ .	Zinc	40-44	amyloid beta precursor protein	Homo sapiens	111-116
27501363-6	2016	This impairment is overcome when excess Zn2+ is applied, suggesting that impaired Ca2+ -signaling results from Abeta binding of Zn2+ .	Zinc	128-132	amyloid beta precursor protein	Homo sapiens	111-116
27501363-8	2016	Importantly, neuronal Zn2+ -dependent extracellular regulated kinase1/2 phosphorylation and up-regulation of Clu are attenuated by silencing mZnR/GPR39 as well as by Abeta treatment.	Zinc	22-26	amyloid beta precursor protein	Homo sapiens	166-171
27501363-11	2016	Synaptically released Zn2+ activates a Zn2+ -sensing receptor, mZnR/GPR39, and induces Ca2+ -signaling, followed by ERK1/2 MAPK activation and up-regulation of clusterin.	Zinc	22-26	mitogen-activated protein kinase 3	Homo sapiens	116-122
27501363-11	2016	Synaptically released Zn2+ activates a Zn2+ -sensing receptor, mZnR/GPR39, and induces Ca2+ -signaling, followed by ERK1/2 MAPK activation and up-regulation of clusterin.	Zinc	22-26	mitogen-activated protein kinase 3	Homo sapiens	123-127
27501363-12	2016	Amyloid beta (Abeta) binds to Zn2+ thus forming oligomers that are a hallmark of Alzheimer"s disease.	Zinc	30-34	amyloid beta precursor protein	Homo sapiens	14-19
27501363-13	2016	We show that Abeta attenuates Zn2+ -dependent Ca2+ -responses, abolishes ERK1/2 activation and down-regulates clusterin expression.	Zinc	30-34	amyloid beta precursor protein	Homo sapiens	13-18
26497033-6	2016	Zn caused neurobehavioral impairments and reduction in dopamine and its metabolites, tyrosine hydroxylase (TH)-positive neurons, catalase activity, and expression of TH, Bcl-2, and NOXA.	Zinc	0-2	BCL2, apoptosis regulator	Rattus norvegicus	170-175
26497033-7	2016	On the contrary, Zn augmented lipid peroxidation, activity of superoxide dismutase, expression of TNF-alpha, IL-1beta, Bcl-xl, and p53-upregulated modulator of apoptosis (PUMA), and translocation of NF-kappaB and Bax from the cytosol to the nucleus and mitochondria, respectively, with concomitant increase in the mitochondrial cytochrome c release and activation of procaspase-3 and -9.	Zinc	17-19	tumor necrosis factor	Rattus norvegicus	98-107
26497033-7	2016	On the contrary, Zn augmented lipid peroxidation, activity of superoxide dismutase, expression of TNF-alpha, IL-1beta, Bcl-xl, and p53-upregulated modulator of apoptosis (PUMA), and translocation of NF-kappaB and Bax from the cytosol to the nucleus and mitochondria, respectively, with concomitant increase in the mitochondrial cytochrome c release and activation of procaspase-3 and -9.	Zinc	17-19	interleukin 1 beta	Rattus norvegicus	109-117
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	Zinc	32-34	interleukin 6	Homo sapiens	146-150
27427241-9	2016	However, the NF-kappaB pathway appeared predominately to be involved only in Zn(2+)- and As(3+)-induced CXCL8 and IL-6 responses.	Zinc	77-79	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
27427241-9	2016	However, the NF-kappaB pathway appeared predominately to be involved only in Zn(2+)- and As(3+)-induced CXCL8 and IL-6 responses.	Zinc	77-79	interleukin 6	Homo sapiens	114-118
27653687-0	2016	IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.	Zinc	80-82	interleukin 4	Homo sapiens	0-4
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	72-74	interleukin 4	Homo sapiens	13-31
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	interleukin 4	Homo sapiens	13-31
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	interleukin 4	Homo sapiens	13-31
27653687-4	2016	IL-4 regulates this pathway by shuttling extracellular Zn into macrophages and by activating cathepsins that act on MT3 to release bound Zn.	Zinc	55-57	interleukin 4	Homo sapiens	0-4
27653687-4	2016	IL-4 regulates this pathway by shuttling extracellular Zn into macrophages and by activating cathepsins that act on MT3 to release bound Zn.	Zinc	137-139	interleukin 4	Homo sapiens	0-4
27653687-5	2016	We show that IL-4 can modulate Zn homeostasis in both human monocytes and mice.	Zinc	31-33	interleukin 4	Homo sapiens	13-17
27501363-14	2016	Thus, Zn2+ signaling via mZnR/GPR39 is disrupted by Abeta, a critical pathological component of Alzheimer"s disease.	Zinc	6-10	amyloid beta precursor protein	Homo sapiens	52-57
27590123-7	2016	We suggest that nitrate and Zn2+ activate a late slower component of the DeltaF/F signals of frog but not of mouse fibres, possibly promoting Ca2+ induced Ca2+ release at level of the RyR3, that in frog muscle fibres are localized in the para-junctional region of the triads and are absent in mouse FDB muscle fibres.	Zinc	28-32	ryanodine receptor 3	Mus musculus	184-188
27427241-4	2016	Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM.	Zinc	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
27427241-4	2016	Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM.	Zinc	20-22	interleukin 6	Homo sapiens	56-60
27713689-10	2016	We conclude that diffusible Zn2+ reaches 1 muM or higher and is therefore likely to be phasically released in artificial glycinergic synapses.	Zinc	28-32	latexin	Homo sapiens	43-46
27475536-10	2016	The calculations revealed that SN-1 binds to the C-terminal domain through Zn(2+), H(216), P(247), C(288), and Y(315).	Zinc	75-77	solute carrier family 38 member 3	Homo sapiens	31-35
27711752-1	2016	Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway.	Zinc	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
27320438-4	2016	The catalytic reactions between 2,2",4,4",5,5"-hexachlorobiphenyl (PCB-153) and AC-supported Fe, Ni, Cu and Zn catalysts were conducted under N2 atmosphere.	Zinc	108-110	pyruvate carboxylase	Homo sapiens	67-70
31968814-3	2016	Single-crystal X-ray diffraction experiments showed that the MOF contains an imidazolium-based rotaxane linked by dimeric [Zn2 (NO3 )(DEF)] secondary building units (SBUs).	Zinc	123-126	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
27365126-5	2016	The limit of detection for Zn(2+) was estimated as 2.1 muM.	Zinc	27-29	latexin	Homo sapiens	55-58
26952193-4	2016	Docking calculations showed that TRAIL in homotrimer configuration was more stable than in heterotrimer, because of the presence of one Zn ion in its structure.	Zinc	136-138	TNF superfamily member 10	Homo sapiens	33-38
26952193-5	2016	Indeed, TRAIL trimers can have head-to-tail orientations when Zn is missing.	Zinc	62-64	TNF superfamily member 10	Homo sapiens	8-13
27519859-8	2016	Second, the contribution of LeNRAMP2 expression in the stele is shown to be distinct for wild-type and transgenic plants at both Zn exposures.	Zinc	129-131	metal transporter Nramp2	Solanum lycopersicum	28-36
27323295-7	2016	On the contrary, Zn up-regulated the levels of mRNA, protein and activity of Cu/Zn-SOD, which may contribute to the decreased LPO levels.	Zinc	17-19	superoxide dismutase 1, soluble	Danio rerio	77-86
27185213-5	2016	We hypothesized that: (1) the skin cancer burdens would be reduced by Zn supplementation; (2) Fhit(-/-) (Fhit, murine fragile histidine triad gene) mice would show increased susceptibility to skin tumor induction versus wild-type mice.	Zinc	70-72	fragile histidine triad gene	Mus musculus	94-103
27185213-5	2016	We hypothesized that: (1) the skin cancer burdens would be reduced by Zn supplementation; (2) Fhit(-/-) (Fhit, murine fragile histidine triad gene) mice would show increased susceptibility to skin tumor induction versus wild-type mice.	Zinc	70-72	fragile histidine triad gene	Mus musculus	94-98
27185213-6	2016	30 weeks after initiating treatment, the tumor burden was increased ~2-fold in Fhit(-/-) versus wild-type mice (16.2 versus 7.6 tumors, P &lt; 0.001); Zn supplementation significantly reduced tumor burdens in Fhit(-/-) mice (males and females combined, 16.2 unsupplemented versus 10.3 supplemented, P = 0.001).	Zinc	151-153	fragile histidine triad gene	Mus musculus	79-83
27185213-6	2016	30 weeks after initiating treatment, the tumor burden was increased ~2-fold in Fhit(-/-) versus wild-type mice (16.2 versus 7.6 tumors, P &lt; 0.001); Zn supplementation significantly reduced tumor burdens in Fhit(-/-) mice (males and females combined, 16.2 unsupplemented versus 10.3 supplemented, P = 0.001).	Zinc	151-153	fragile histidine triad gene	Mus musculus	209-213
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	alopecia, recessive	Mus musculus	129-132
27430886-3	2016	Here we summarize current knowledge of S100 protein binding of Zn(2+), Cu(2+) and Mn(2+) ions, focusing on binding affinities, conformational changes that arise from metal binding, and the roles of transition metal binding in S100 protein function.	Zinc	63-65	S100 calcium binding protein B	Homo sapiens	39-43
27177354-15	2016	The induction of IL-8 in Beas-2B cells was significantly associated with Cu, Ni and Zn and endotoxin.	Zinc	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	bone morphogenetic protein 2	Mus musculus	134-139
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	tumor necrosis factor	Mus musculus	216-225
27547395-6	2016	Mean daily total dietary intakes of Fe, Zn, vitamin A and vitamin D were significantly higher in the fortified milk group.	Zinc	40-42	Weaning weight-maternal milk	Bos taurus	111-115
27390586-11	2016	Over-expression of ZnT8 in glucagonoma-derived alphaTC1-9 cells increased granule free Zn(2+) concentrations consistent with a role for Zn(2+) in this compartment in the action of ZnT8 on glucagon secretion.	Zinc	19-21	solute carrier family 30 (zinc transporter), member 8	Mus musculus	180-184
27523482-7	2016	Although, both Cu and Zn ions were present in MT1 samples isolated from all the treatment groups.	Zinc	22-24	metallothionein 1	Rattus norvegicus	46-49
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Zinc	169-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	alkaline phosphatase, placental	Homo sapiens	177-180
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	RUNX family transcription factor 2	Homo sapiens	182-217
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	RUNX family transcription factor 2	Homo sapiens	219-224
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	vascular endothelial growth factor A	Homo sapiens	250-286
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	vascular endothelial growth factor A	Homo sapiens	288-294
27463142-3	2016	Zinc (Zn(2+)) is cosecreted with insulin, and has been postulated to play a role in cell-to-cell cross talk within an islet, in particular inhibiting glucagon secretion from alpha-cells.	Zinc	6-12	insulin	Homo sapiens	33-40
27107934-8	2016	These results suggest that zinc is a novel stimulant for CCK secretion through the activation of TRPA1 related to intracellular Zn(2+) and Ca(2+) mobilization.	Zinc	128-134	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	97-102
27390586-11	2016	Over-expression of ZnT8 in glucagonoma-derived alphaTC1-9 cells increased granule free Zn(2+) concentrations consistent with a role for Zn(2+) in this compartment in the action of ZnT8 on glucagon secretion.	Zinc	87-89	solute carrier family 30 (zinc transporter), member 8	Mus musculus	19-23
27305175-3	2016	Here we, for the first time, study the impact of GAGs in combination with Zn(2+) on the reversible hPRL aggregation across the pH range of 7.4-5.5.	Zinc	74-76	prolactin	Homo sapiens	99-103
27175795-0	2016	External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation.	Zinc	9-15	CF transmembrane conductance regulator	Homo sapiens	48-99
27305175-4	2016	Zn(2+) alone causes hPRL aggregation at pH 7.4, while aggregation between pH 7.4 and 5.5 requires both Zn(2+) and GAGs.	Zinc	0-2	prolactin	Homo sapiens	20-24
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	16-18	prolactin	Homo sapiens	30-34
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	16-18	prolactin	Homo sapiens	92-96
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	16-18	prolactin	Homo sapiens	92-96
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	30-34
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	92-96
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	92-96
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	30-34
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	92-96
27305175-7	2016	We propose that Zn(2+) causes hPRL aggregation through low-affinity Zn(2+) binding sites on hPRL with GAGs facilitating Zn(2+) binding by neutralizing repulsive positive charges of hPRL in the acidic environments of the TGN and mature secretory granules.	Zinc	68-70	prolactin	Homo sapiens	92-96
27278808-15	2016	CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6.	Zinc	35-37	interleukin 6	Homo sapiens	176-180
27251140-1	2016	Since many Zn complexes have been developed to enhance the insulin-like activity and increase the exposure and residence of Zn in the animal body, these complexes are recognized as one of the new candidates with action mechanism different from existing anti-diabetic drugs.	Zinc	11-13	insulin	Homo sapiens	59-66
27251140-3	2016	Therefore, we evaluated the activity of Zn complexes, especially related to the phosphorylation of insulin signaling pathway components.	Zinc	40-42	insulin	Homo sapiens	99-106
27307058-3	2016	The stability of the Zn(2+)-chelated Zn-finger domain of XPA center core portion (i.e., XPA98-210) is the foundation of its biological functionality, while the displacement of the Zn(2+) by toxic metal ions (such as Ni(2+), a known human carcinogen and allergen) may impair the effectiveness of NER and hence elevate the chance of carcinogenesis.	Zinc	21-23	XPA, DNA damage recognition and repair factor	Homo sapiens	57-60
27307058-3	2016	The stability of the Zn(2+)-chelated Zn-finger domain of XPA center core portion (i.e., XPA98-210) is the foundation of its biological functionality, while the displacement of the Zn(2+) by toxic metal ions (such as Ni(2+), a known human carcinogen and allergen) may impair the effectiveness of NER and hence elevate the chance of carcinogenesis.	Zinc	37-39	XPA, DNA damage recognition and repair factor	Homo sapiens	57-60
27427745-4	2016	Under the optimum conditions, the calibration curve of this method showed good linearity in the concentration range of 9.1-1 09.1 muM of Zn2+ with the correlation coefficient R2 = 0.998.	Zinc	137-141	latexin	Homo sapiens	130-133
27251638-7	2016	Additionally, IL-10 secretion is increased in MT knockout Tr1 cells compared with wildtype controls and this increase is prevented when the intracellular [Zn(2+)] is increased experimentally.	Zinc	155-157	interleukin 10	Mus musculus	14-19
26507438-7	2016	There were linear responses to the addition of Zn-Gly from 0 to 180 mg Zn/kg on Cu-Zn SOD and AKP activities in the liver.	Zinc	47-49	superoxide dismutase 1	Rattus norvegicus	80-89
26507438-8	2016	In the duodenum, MT1 mRNA was upregulated with the increasing dietary Zn-Gly levels and reached the peak of 180 mg Zn/kg (P &lt; 0.05).	Zinc	70-72	metallothionein 1	Rattus norvegicus	17-20
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-37	S100 calcium binding protein B	Homo sapiens	52-56
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-33	S100 calcium binding protein B	Homo sapiens	52-56
27038207-4	2016	Amylase (for C cycling), acid phosphatase (for P cycling) and catalase (for redox reaction) activities showed significantly positive correlations (P &lt; 0.05) with Pb, Cd, Zn and As contents.	Zinc	173-175	catalase	Homo sapiens	47-70
27038207-5	2016	The correlations between soil enzymes activities and Cd, Pb and Zn contents were verified in microcosm experiments, it was found that catalase activity had significant correlations (P &lt; 0.05) with these three metals in short-term experiments using different soils under different conditions.	Zinc	64-66	catalase	Homo sapiens	134-142
26857037-7	2016	Zn administration during simultaneous exposure to E2 and Cd strongly stimulated zebrafish ERs transactivation and increased Aro-B protein expression, whereas mRNA levels of the three ERs as well as the cyp19a1b remained unchanged in comparison with Cd-treated embryos.	Zinc	0-2	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	124-129
27060822-13	2016	Minerals (Mg, P, Na, K, Ca, Zn) in milk were not affected by the added iron in milk.	Zinc	28-30	Weaning weight-maternal milk	Bos taurus	35-39
27195669-11	2016	Despite similar p53 activation profiles, these data revealed widespread dampening of p53 and NRF2-related genes as early as 4 h after exposure at higher, unrecoverable Zn2+ exposures.	Zinc	168-172	tumor protein p53	Homo sapiens	85-88
26850126-8	2016	In addition, EP markedly reduced the expressions of PARP-1 and of the NADPH oxidase subunit in Zn(2+)-treated primary cortical neurons, well known Zn(2+)-induced downstream processes.	Zinc	95-101	poly(ADP-ribose) polymerase 1	Homo sapiens	52-58
31557994-6	2016	Zn-beads saturated with human fibrinogen could bind human IgG, and Zn-beads saturated with human IgG could bind fibrinogen.	Zinc	0-2	fibrinogen beta chain	Homo sapiens	30-40
31557994-6	2016	Zn-beads saturated with human fibrinogen could bind human IgG, and Zn-beads saturated with human IgG could bind fibrinogen.	Zinc	67-69	fibrinogen beta chain	Homo sapiens	112-122
26951338-3	2016	Furthermore, the application of AC1, AC2, AC3, AC4 on different heavy metal (Cu(2+), Zn(2+), Pb(2+), Cr(3+)) removals was explored to investigate their adsorption properties.	Zinc	85-87	adenylate cyclase 4	Homo sapiens	47-50
26951338-6	2016	Among the four samples, AC1 exhibits the highest adsorption capacity for Cu(2+); the highest adsorption capacities of Pb(2+) and Zn(2+) are obtained for AC2; that of Cr(3+) are obtained for AC4.	Zinc	129-131	adenylate cyclase 2	Homo sapiens	153-156
27410155-1	2016	A more than 1.5 octave-spanning mid-infrared supercontinuum (1.2 to 3.6 mum) is generated by pumping a As&lt;sub&gt;2&lt;/sub&gt;S&lt;sub&gt;3&lt;/sub&gt;-silica "double-nanospike" waveguide via a femtosecond Cr:ZnS laser at 2.35 mum.	Zinc	212-215	latexin	Homo sapiens	72-75
27195669-11	2016	Despite similar p53 activation profiles, these data revealed widespread dampening of p53 and NRF2-related genes as early as 4 h after exposure at higher, unrecoverable Zn2+ exposures.	Zinc	168-172	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
27159591-7	2016	Biochemical studies are presented indicating S-nitrosylation tunes the conformation of S100B and modulates its Ca2+ and Zn2+ binding properties.	Zinc	120-124	S100 calcium binding protein B	Homo sapiens	87-92
27086777-1	2016	Here, we report a redox-mediated indirect fluorescence immunoassay (RMFIA) for the detection of the disease biomarker alpha-fetoprotein (AFP) using dopamine (DA)-functionalized CdSe/ZnS quantum dots (QDs).	Zinc	182-185	alpha fetoprotein	Homo sapiens	118-135
27086777-1	2016	Here, we report a redox-mediated indirect fluorescence immunoassay (RMFIA) for the detection of the disease biomarker alpha-fetoprotein (AFP) using dopamine (DA)-functionalized CdSe/ZnS quantum dots (QDs).	Zinc	182-185	alpha fetoprotein	Homo sapiens	137-140
27144270-9	2016	Cu, Pb, and Zn primarily originate from ash in the suspended sediment.	Zinc	12-14	arylsulfatase family member H	Homo sapiens	40-43
26940795-5	2016	During the early stage of exposure for 6 h, the 8 mg L(-1) Zn exposure sharply increased mRNA levels of Cu/Zn-SOD, CAT, GPx1b, Nrf2, and Keap1, whereas, the 4 mg L(-1) Zn exposure did not significantly affect the expression of these genes.	Zinc	59-61	kelch-like ECH-associated protein 1	Larimichthys crocea	137-142
26400651-6	2016	Chelation of Zn(2+) by the membrane permeable chelator N,N,N",N"-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) reduced granulocyte migration toward N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF) and IL-8, indicating a role of free intracellular Zn(2+) in chemotaxis.	Zinc	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	117-119	interleukin 1 beta	Homo sapiens	238-246
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	117-119	interleukin 6	Homo sapiens	248-252
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	117-119	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	165-167	interleukin 1 beta	Homo sapiens	238-246
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	165-167	interleukin 6	Homo sapiens	248-252
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	165-167	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
26940795-7	2016	Furthermore, a sharp increase in Keap1 expression levels was observed in fish exposed to 4 mg L(-1) at 96 h, and 8 mg L(-1) at 6, 48, and 96 h. In conclusion, the present study demonstrated that Zn-induced antioxidant defenses were involved in modifications at enzymatic and transcriptional levels and the transcriptional regulation of the Nrf2-Keap1 signaling molecule; these results may contribute to the understanding of mechanisms that maintain the correct redox balance in the immune organ of the large yellow croaker.	Zinc	195-197	kelch-like ECH-associated protein 1	Larimichthys crocea	33-38
26940795-7	2016	Furthermore, a sharp increase in Keap1 expression levels was observed in fish exposed to 4 mg L(-1) at 96 h, and 8 mg L(-1) at 6, 48, and 96 h. In conclusion, the present study demonstrated that Zn-induced antioxidant defenses were involved in modifications at enzymatic and transcriptional levels and the transcriptional regulation of the Nrf2-Keap1 signaling molecule; these results may contribute to the understanding of mechanisms that maintain the correct redox balance in the immune organ of the large yellow croaker.	Zinc	195-197	kelch-like ECH-associated protein 1	Larimichthys crocea	345-350
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
30001042-7	2016	The results show that the Pb(II)-MICA displayed strong affinity for Pb(II) in the solution and exhibited selectivity for Pb(II) ion in the presence of Cu2+,Cd2+,Ni2+ and Zn2+.	Zinc	170-174	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
30001042-7	2016	The results show that the Pb(II)-MICA displayed strong affinity for Pb(II) in the solution and exhibited selectivity for Pb(II) ion in the presence of Cu2+,Cd2+,Ni2+ and Zn2+.	Zinc	170-174	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
30001042-7	2016	The results show that the Pb(II)-MICA displayed strong affinity for Pb(II) in the solution and exhibited selectivity for Pb(II) ion in the presence of Cu2+,Cd2+,Ni2+ and Zn2+.	Zinc	170-174	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
26900671-4	2016	While the gas adsorption experiments reveal that Cu(II) and Co(II) exchanged samples exhibit comparable CO2 adsorption capability to the pristine Zn(II) -based MOF under the same conditions, catalytic investigations for the cycloaddition reaction of CO2 with epoxides into related carbonates demonstrate that Zn(II) -based MOF affords the highest catalytic activity as compared with Cu(II) and Co(II) exchanged ones.	Zinc	309-315	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-66
27044837-3	2016	In brain, Zn(2+) has been identified as a ligand, capable of activating and inhibiting the receptors including the NMDA-type glutamate receptors (NMDARs), GABAA receptors, nicotinic acetylcholine receptors (nAChRs), glycine receptors (glyR) and serotonin receptors (5-HT3).	Zinc	10-12	5-hydroxytryptamine receptor 3A	Homo sapiens	266-272
27121137-2	2016	Formation of amyloid-beta plaque cores (APC) is related to interactions with biometals, especially Fe, Cu and Zn, but their particular structural associations and roles remain unclear.	Zinc	110-112	amyloid beta precursor protein	Homo sapiens	13-25
27032066-7	2016	The transferrin adsorption is accompanied by the removal of the ZnS shell, resulting in evolving two different metal-protein conjugated forms.	Zinc	64-67	transferrin	Homo sapiens	4-15
27147951-0	2016	Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.	Zinc	79-81	fragile X messenger ribonucleoprotein 1	Homo sapiens	19-49
27147951-0	2016	Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.	Zinc	79-81	fragile X messenger ribonucleoprotein 1	Homo sapiens	51-55
26828278-1	2016	Zinc-aluminum layered double hydroxides with nitrate intercalated (Zn(n)Al-NO3, n=Zn/Al) is an intermediate material for the intercalation of different functional molecules used in a wide range of industrial applications.	Zinc	67-69	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
26938528-0	2016	Molecular Recognition of the Catalytic Zinc(II) Ion in MMP-13: Structure-Based Evolution of an Allosteric Inhibitor to Dual Binding Mode Inhibitors with Improved Lipophilic Ligand Efficiencies.	Zinc	39-47	matrix metallopeptidase 13	Homo sapiens	55-61
26909543-10	2016	The binding constants for Ca(2+), Cu(2+), and Zn(2+) were 7.0 x 10(5), 4.2 x 10(5), and 1.7 x 10(5) M(-1), respectively, indicating 2-4-fold higher selectivity of CBP for Ca(2+) compared to Cu(2+) and Zn(2+).	Zinc	46-48	CREB binding protein	Homo sapiens	163-166
26936488-11	2016	Both Zn(II)-CP-1(CAHH) and Co(II)-CP-1(CAHH) show good hydrolytic activity toward the test substrate 4-nitrophenyl acetate, exhibiting faster rates than most active synthetic Zn(II) complexes.	Zinc	5-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-33
27004850-3	2016	Moreover, to demonstrate the formation of GH amyloid in vitro, we studied various conditions (solvents, glycosaminoglycans, salts and metal ions) and found that in presence of zinc metal ions (Zn(II)), GH formed short curvy fibrils.	Zinc	193-195	growth hormone 1	Homo sapiens	42-44
27004850-5	2016	Our biophysical studies also suggest that Zn(II) initiates the early oligomerization of GH that eventually facilitates the fibrillation process.	Zinc	42-48	growth hormone 1	Homo sapiens	88-90
26932583-5	2016	In the present studies we explored the potential of a coordination complex of Zn(II) and anthracenyl-terpyridine as a modulator of the parathyroid hormone response.	Zinc	78-84	parathyroid hormone	Homo sapiens	135-154
26787488-8	2016	Gene expressions of early markers of osteoblast differentiation (COL-I and ALP mRNA) were obviously improved on Zn-modified coating.	Zinc	112-114	alopecia, recessive	Mus musculus	75-78
26762534-0	2016	Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron(II) and Zinc(II) Ions at Distinct Sites.	Zinc	85-93	insulin	Homo sapiens	16-23
26857501-8	2016	When using near-physiological doses (up to 10x the normal plasma concentration), only Zn and Cu induced significant IL-8 production.	Zinc	86-88	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26753183-5	2016	Upon collision-induced dissociation (CID), Zn(II)Por/Pc formate supramolecular complexes can undergo the loss of CO2 in combination with transfer of a hydride anion (H(-)) to the zinc metal center.	Zinc	179-189	cytochrome p450 oxidoreductase	Homo sapiens	49-52
26551835-7	2016	We identified three residues that affect the affinity for the structural Zn(2+) and determine the folding of ZF2 in the absence of RNA.	Zinc	73-75	zinc finger protein 274	Homo sapiens	109-112
26845700-8	2016	RESULTS: Exposure to IL-17 and TNF-alpha enhanced expression of the Zn-importer ZIP-8, regardless of the concentration of Zn in the culture medium.	Zinc	68-70	tumor necrosis factor	Homo sapiens	31-40
26845700-9	2016	In contrast, the expression of the Zn-exporter ZnT1 and of the MTs was primarily dependent on Zn levels.	Zinc	35-37	solute carrier family 30 member 1	Homo sapiens	47-51
26845700-10	2016	Addition of Zn also increased the production of IL-6, thus further stimulating the inflammatory response.	Zinc	12-14	interleukin 6	Homo sapiens	48-52
26845700-11	2016	CONCLUSION: IL-17/TNF-mediated inflammation enhanced the intracellular Zn uptake by synoviocytes, further increasing inflammation.	Zinc	71-73	tumor necrosis factor	Homo sapiens	18-21
26913170-3	2016	In this work, we present results from metal-binding studies and microbiology assays designed to ascertain whether Ca(II) ions modulate the Zn(II)-binding properties of S100A12 and further evaluate the antimicrobial properties of this protein.	Zinc	139-145	S100 calcium binding protein A12	Homo sapiens	168-175
26913170-4	2016	Our metal depletion studies reveal that Ca(II) ions enhance the ability of S100A12 to sequester Zn(II) from microbial growth media.	Zinc	96-102	S100 calcium binding protein A12	Homo sapiens	75-82
26913170-10	2016	Loss of functional ZnuABC, a high-affinity Zn(II) import system, increased the susceptibility of E. coli and P. aeruginosa to S100A12, indicating that S100A12 deprives these mutant strains of Zn(II).	Zinc	192-198	S100 calcium binding protein A12	Homo sapiens	151-158
26913170-11	2016	To evaluate the Zn(II)-binding sites of S100A12 in solution, we present studies using Co(II) as a spectroscopic probe and chromophoric small-molecule chelators in Zn(II) competition titrations.	Zinc	16-22	S100 calcium binding protein A12	Homo sapiens	40-47
26913170-12	2016	We confirm that S100A12 binds Zn(II) with a 2:1 stoichiometry, and our data indicate sub-nanomolar affinity binding.	Zinc	30-36	S100 calcium binding protein A12	Homo sapiens	16-23
26913170-13	2016	Taken together, these data support a model whereby S100A12 uses Ca(II) ions to tune its Zn(II)-chelating properties and antimicrobial activity.	Zinc	88-94	S100 calcium binding protein A12	Homo sapiens	51-58
26618301-9	2016	The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of &gt;0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb).	Zinc	224-226	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
27010891-9	2016	Mn(2+), Zn(2+), Co(2+) and Cu(2+) influence KYNU activity, and Mg(2+) regulates quinolinate phosphoribosyl transferase.	Zinc	8-14	kynureninase	Homo sapiens	44-48
26365743-3	2016	Zn2+ ions are essential for a huge range of cellular functions and, in the specialised pancreatic beta-cell, for the storage of insulin within the secretory granule.	Zinc	0-4	insulin	Homo sapiens	128-135
26699282-5	2016	Furthermore, the protective roles of Zn, Se, and Sr were mainly shown among subjects with high levels of BPDE-Alb adducts.	Zinc	37-39	albumin	Homo sapiens	110-113
26671614-1	2016	A solvothermal reaction of Zn(ii) salt with methanetetrabenzoic acid (H4MTB) and 1,4,8,11-tetraazacyclotetradecane (cyclam, CYC) created a new microporous metal-organic framework {[Zn2(mu4-MTB)(kappa(4)-CYC)2] 2DMF 7H2O}n (DMF = N,N"-dimethylformamide).	Zinc	181-184	cytochrome c, somatic	Homo sapiens	124-127
26671614-4	2016	The gas adsorption behaviour of {[Zn2(mu4-MTB)(kappa(4)-CYC)2] 2DMF 7H2O}n was studied by adsorption of Ar, N2, CO2 and H2.	Zinc	32-37	cytochrome c, somatic	Homo sapiens	56-59
26699282-6	2016	Significant effect modification of BPDE-Alb adducts on the associations of Zn, Se, and Sr with MN frequencies was observed (all Pinteraction &lt; 0.05).	Zinc	75-77	albumin	Homo sapiens	40-43
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	97-103	mitogen-activated protein kinase 1	Homo sapiens	131-163
26574547-0	2016	Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.	Zinc	0-4	mitogen-activated protein kinase 1	Homo sapiens	165-169
26574547-0	2016	Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.	Zinc	148-152	mitogen-activated protein kinase 1	Homo sapiens	165-169
26658105-5	2016	Using caspase-6 and -9 exosite analysis, we identified and mutated predicted Zn-ligands in caspase-3 (H108A, C148S and E272A) and overexpressed into DKO MEFs.	Zinc	77-79	caspase 6	Mus musculus	6-22
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	97-103	mitogen-activated protein kinase 1	Homo sapiens	165-169
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	212-218	mitogen-activated protein kinase 1	Homo sapiens	131-163
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	212-218	mitogen-activated protein kinase 1	Homo sapiens	165-169
26574547-8	2016	This interpretation is further supported by the findings that deletion of the STEP gene led to a rapid and sustained increase in ERK2 phosphorylation within minutes of exposure to Zn(2+).	Zinc	180-182	mitogen-activated protein kinase 1	Homo sapiens	129-133
26574547-9	2016	The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2.	Zinc	121-127	mitogen-activated protein kinase 1	Homo sapiens	160-164
26598802-3	2015	An antibody against HER2 protein receptor, EP1045Y, was conjugated with NIR emitting CdSeTe/CdS/ZnS QDs via polyhistidine-driven self-assembly approach.	Zinc	96-99	erb-b2 receptor tyrosine kinase 2	Homo sapiens	20-24
26752283-3	2016	Exposure to Zn2+-limiting conditions resulted in delayed growth in a strain lacking AdcAII (DeltaAdcAII) when compared to wild type bacteria or a mutant lacking AdcA (DeltaAdcA).	Zinc	12-16	ataxin 7	Homo sapiens	84-90
26752283-7	2016	Our findings suggest that expression of AdcAII affects invasiveness of S. pneumoniae in response to available Zn2+ concentrations.	Zinc	110-114	ataxin 7	Homo sapiens	40-46
26584158-1	2016	Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules.	Zinc	123-129	solute carrier family 30 (zinc transporter), member 8	Mus musculus	0-18
26584158-1	2016	Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules.	Zinc	123-129	solute carrier family 30 (zinc transporter), member 8	Mus musculus	20-24
26584158-1	2016	Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules.	Zinc	123-129	solute carrier family 30 (zinc transporter), member 8	Mus musculus	38-45
26276542-0	2015	Silver nanoparticles-enhanced time-resolved fluorescence sensor for VEGF(165) based on Mn-doped ZnS quantum dots.	Zinc	96-99	vascular endothelial growth factor A	Homo sapiens	68-72
26634949-6	2016	Compared to RAC+ pigs, relative expression of IGF1 decreased with increasing levels of Zn on day 8 and 18 of treatment, but expression levels were similar on day 32 due to Zn treatments increasing in expression while the RAC+ treatment decreased (Zn quadratic x day quadratic, P = 0.04).	Zinc	87-89	IGF1	Sus scrofa	46-50
26881707-2	2016	We previously identified the major plasma Zn2+ transport site on HSA and revealed that fatty-acid binding (at a distinct site called the FA2 site) and Zn2+ binding are interdependent via an allosteric mechanism.	Zinc	42-46	albumin	Homo sapiens	65-68
26881707-2	2016	We previously identified the major plasma Zn2+ transport site on HSA and revealed that fatty-acid binding (at a distinct site called the FA2 site) and Zn2+ binding are interdependent via an allosteric mechanism.	Zinc	151-155	albumin	Homo sapiens	65-68
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	Zinc	74-78	albumin	Homo sapiens	163-166
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	Zinc	193-197	albumin	Homo sapiens	163-166
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	Zinc	193-197	albumin	Homo sapiens	189-192
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	Zinc	193-197	albumin	Homo sapiens	163-166
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	Zinc	193-197	albumin	Homo sapiens	189-192
26834307-4	2016	The separation of Co(II) from Zn(II), Ni(II) and Cu(II) was also studied, but the selective recovery of the metals was possible using the multi-stage stripping process.	Zinc	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-24
26583802-6	2016	Through a detailed analysis of spectral data from electrospray ionization mass spectromeric and circular dichroism methods we report that Zn(ii) and Cd(ii) metalation of the human MT1a takes place through two distinct pathways.	Zinc	138-144	metallothionein 1A	Homo sapiens	180-184
26583802-9	2016	We report that there are different pathway preferences for Zn(ii) and Cd(ii) metalation of apo-hMT1a.	Zinc	59-65	metallothionein 1A	Homo sapiens	95-100
26681008-10	2015	These results suggest that dietary Zn may elevate the activity and protein concentration of Cu-Zn SOD, to attenuate testicular oxidative stress induced by heat exposure.	Zinc	35-37	superoxide dismutase 1, soluble	Mus musculus	92-101
26529669-8	2015	Minor alleles of rs8044719 and rs1599823, near MT1A and MT1B, were associated with lower urinary Cd and Zn, respectively.	Zinc	104-106	metallothionein 1A	Homo sapiens	47-51
26884962-7	2015	Compared with control group, gene expression and protein content of MMP-13 in 200 muM Zn group was significantly increased while no difference in gene expression and protein content of TIMP1 was found.	Zinc	86-88	matrix metallopeptidase 13	Homo sapiens	68-74
26409456-3	2015	The purpose of this study was to determine the effects of Zn concentration in cell culture on the expression of miR-548n, SMAD4 and SMAD5 in hepatocyte (HepG2) and lung epithelium (HEp-2) cell lines.	Zinc	58-60	SMAD family member 5	Homo sapiens	132-137
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	SMAD family member 5	Homo sapiens	10-15
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	transforming growth factor beta 1	Homo sapiens	33-41
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	SMAD family member 5	Homo sapiens	69-74
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	SMAD family member 5	Homo sapiens	69-74
26409456-12	2015	However, SMAD5 expression may be more sensitive to Zn than to miR-548n since SMAD5 expression was not inversely correlated with miR-548n expression.	Zinc	51-53	SMAD family member 5	Homo sapiens	9-14
26555713-0	2015	Molecular interaction investigation between three CdTe:Zn(2+) quantum dots and human serum albumin: A comparative study.	Zinc	55-57	albumin	Homo sapiens	85-98
26297535-5	2015	Furthermore, Zn administered 3 h before the decapitation increased the level of brain derived neurotrophic factor (BDNF), GluA1 and synapsin I.	Zinc	13-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
26297535-6	2015	An elevated level of GluA1 and synapsin I was still observed 24 h after the Zn treatment, although Zn did not produce any effects in the FST at that time point.	Zinc	76-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	21-26
26540617-0	2015	Quinone-Modified Mn-Doped ZnS Quantum Dots for Room-Temperature Phosphorescence Sensing of Human Cancer Cells That Overexpress NQO1.	Zinc	26-29	NAD(P)H quinone dehydrogenase 1	Homo sapiens	127-131
26540617-3	2015	An efficient room-temperature phosphorescence NQO1 probe was constructed by using Mn-doped ZnS quantum dots (Mn:ZnS QDs) as donors and trimethylquinone propionic acids as acceptors.	Zinc	91-94	NAD(P)H quinone dehydrogenase 1	Homo sapiens	46-50
26540617-3	2015	An efficient room-temperature phosphorescence NQO1 probe was constructed by using Mn-doped ZnS quantum dots (Mn:ZnS QDs) as donors and trimethylquinone propionic acids as acceptors.	Zinc	112-115	NAD(P)H quinone dehydrogenase 1	Homo sapiens	46-50
26540617-5	2015	Phosphorescence of Mn:ZnS QDs was turned on by the rapid reduction-initiated removal of the quinone quencher by NQO1.	Zinc	22-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	112-116
26272065-9	2015	Contrasting modulation profiles at 4 and 12  C were seen for all three chemokines during the wound healing time course, while the Zn-supplemented diets significantly increased the expression of CK 11A and B during the first 24 h of the healing phase.	Zinc	130-132	creatine kinase B-type	Salmo salar	194-206
26354774-8	2015	The blockage in TGFbeta2-Smad signaling is likely due to the loss of Zn(2+) cofactor in Smad proteins, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenite.	Zinc	69-71	transforming growth factor, beta 2	Mus musculus	16-24
26354774-8	2015	The blockage in TGFbeta2-Smad signaling is likely due to the loss of Zn(2+) cofactor in Smad proteins, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenite.	Zinc	69-71	SMAD family member 2	Mus musculus	156-163
26354774-8	2015	The blockage in TGFbeta2-Smad signaling is likely due to the loss of Zn(2+) cofactor in Smad proteins, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenite.	Zinc	69-75	transforming growth factor, beta 2	Mus musculus	16-24
26354774-8	2015	The blockage in TGFbeta2-Smad signaling is likely due to the loss of Zn(2+) cofactor in Smad proteins, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenite.	Zinc	69-75	SMAD family member 2	Mus musculus	156-163
26439450-4	2015	Reactions of Cu(NO3 )2  2.5 H2 O, CuO, and ZnO with the neat 2:1 1-mim/4,5-DCNIm melt resulted in the isolation of entirely N-donor ligated complexes of the formula M(4,5-DCNIm)2 (1-mim)4 (M=Cu, Zn).	Zinc	43-45	NBL1, DAN family BMP antagonist	Homo sapiens	13-19
26509841-1	2015	Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers.	Zinc	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26884962-11	2015	Zn could significantly inhibit the expression of alphaSMA and type I collagen by inhibiting TGF-beta RI expression and promoting MMP-13 expression.	Zinc	0-2	matrix metallopeptidase 13	Homo sapiens	129-135
26194349-4	2015	Chiral assembly, distinct classes of fibers, 3-D sheets, and metallo-spheres/fibrils with muM levels of Co/Cu/Zn(ii) ions emerged from this new approach of assorted morphosynthesis under ambient conditions.	Zinc	110-116	latexin	Homo sapiens	90-93
26205328-5	2015	Here, we describe recent work defining a new class of drugs termed zinc metallochaperones that restore WT p53 structure and function by restoring Zn(2+) to Zn(2+)-deficient mutant p53.	Zinc	146-148	tumor protein p53	Homo sapiens	106-109
26205328-5	2015	Here, we describe recent work defining a new class of drugs termed zinc metallochaperones that restore WT p53 structure and function by restoring Zn(2+) to Zn(2+)-deficient mutant p53.	Zinc	146-148	tumor protein p53	Homo sapiens	180-183
26205328-5	2015	Here, we describe recent work defining a new class of drugs termed zinc metallochaperones that restore WT p53 structure and function by restoring Zn(2+) to Zn(2+)-deficient mutant p53.	Zinc	156-158	tumor protein p53	Homo sapiens	106-109
26205328-5	2015	Here, we describe recent work defining a new class of drugs termed zinc metallochaperones that restore WT p53 structure and function by restoring Zn(2+) to Zn(2+)-deficient mutant p53.	Zinc	156-158	tumor protein p53	Homo sapiens	180-183
26500268-4	2015	Furthermore, supplemental Zn increased activities of malate dehydrogenase (MDH) and lipoprotein lipase (LPL) in the abdominal fat (P &lt; 0.05), and fatty acid synthetase (FAS) and LPL in the liver (P &lt; 0.01), which were accompanied with up-regulation (P &lt; 0.01) of the mRNA expressions levels of these enzymes in the abdominal fat and liver of broilers.	Zinc	26-28	malate dehydrogenase	Glycine max	53-73
26493598-6	2015	We then show that U87- p53 inactivity can be rescued by zinc (Zn).	Zinc	62-64	tumor protein p53	Homo sapiens	23-26
26084641-7	2015	Moreover, we revealed the existence of a pool of fALS mutants SOD1 pI isoforms, slightly expressed (<10%), with a low Cu/Zn ratio and high pI values.	Zinc	121-123	superoxide dismutase 1	Homo sapiens	62-66
26190797-5	2015	Zn-Por moieties in SNG keep the photosensitivity in the range of visible wavelength and possess the ability of generating active oxygen species for photodynamic therapy.	Zinc	0-2	cytochrome p450 oxidoreductase	Homo sapiens	3-6
26370442-4	2015	Electronic absorption and fluorescence titration studies of H3L with different metal cations show a distinctive recognition only towards Cu(2+) ions even in the presence of other commonly coexisting ions such as Li(+), Na(+), K(+), Mg(2+), Ca(2+), Fe(2+), Fe(3+), Mn(2+), Co(2+), Ni(2+), Zn(2+), Cd(2+) and Hg(2+).	Zinc	288-290	H3 clustered histone 2	Homo sapiens	60-63
26174742-9	2015	Interestingly, we found that Zn(2+) stimulated the phosphorylation of eIF2alpha and promoted the nuclear accumulation of activating transcription factor 4 (ATF4).	Zinc	29-35	activating transcription factor 4	Rattus norvegicus	121-154
26174742-9	2015	Interestingly, we found that Zn(2+) stimulated the phosphorylation of eIF2alpha and promoted the nuclear accumulation of activating transcription factor 4 (ATF4).	Zinc	29-35	activating transcription factor 4	Rattus norvegicus	156-160
26174742-10	2015	Treatment with salubrinal, an eIF2alpha dephosphorylation inhibitor, enhanced Zn(2+)-induced ATF4 accumulation and IL-23 p19 mRNA expression.	Zinc	78-84	activating transcription factor 4	Rattus norvegicus	93-97
26174742-11	2015	In addition, reporter assay using the IL-23 p19 promoter region revealed that ATF4 directly transactivated IL-23 p19 promoter and that dominant-negative ATF4 suppressed Zn(2+)-induced activation of IL-23 p19 promoter.	Zinc	169-171	activating transcription factor 4	Rattus norvegicus	153-157
26174742-12	2015	Taken together, these findings suggest that Zn(2+) up-regulates expression of the IL-23 p19 gene via the eIF2alpha/ATF4 axis in HAPI cells.	Zinc	44-50	activating transcription factor 4	Rattus norvegicus	115-119
26335275-7	2015	The increased accumulations of dimethoate and Zn in the liver reduced its cholinesterase activity from 5.64 +- 0.45 U/mg protein to 4.67 +- 0.42 U/mg protein or 4.76 +- 0.45 U/mg protein for nano or bulk ZnO, respectively.	Zinc	46-48	butyrylcholinesterase	Mus musculus	74-88
25808614-2	2015	Recently, we demonstrated that tumor necrosis factor-alpha (TNFalpha), a cytokine released during early involution, redistributes the zinc (Zn) transporter ZnT2 to accumulate Zn in lysosomes and activate LCD and involution.	Zinc	140-142	tumor necrosis factor	Homo sapiens	31-58
25808614-2	2015	Recently, we demonstrated that tumor necrosis factor-alpha (TNFalpha), a cytokine released during early involution, redistributes the zinc (Zn) transporter ZnT2 to accumulate Zn in lysosomes and activate LCD and involution.	Zinc	140-142	tumor necrosis factor	Homo sapiens	60-68
25808614-6	2015	Mutation of the dileucine motif (L294V) eliminated the ability of TNFalpha to redistribute ZnT2 from late endosomes to lysosomes, increase lysosomal Zn, or activate LCD.	Zinc	91-93	tumor necrosis factor	Homo sapiens	66-74
26425034-5	2015	Ni(2+) and Zn(2+) also stabilized HIF-1alpha with depletion of the free ubiquitin pool and these effects of metal ions were attenuated by restoration of free ubiquitin.	Zinc	11-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
26314369-0	2015	Zn(II)-curc targets p53 in thyroid cancer cells.	Zinc	0-6	tumor protein p53	Homo sapiens	20-23
26314369-5	2015	Here, we investigated whether Zn(II)-curc could affect p53 in thyroid cancer cells with both p53 mutation (R273H) and wild-type p53.	Zinc	30-36	tumor protein p53	Homo sapiens	55-58
26314369-8	2015	In addition, Zn(II)-curc triggered p53 target gene expression in wild-type p53-carrying cells.	Zinc	13-19	tumor protein p53	Homo sapiens	35-38
26314369-8	2015	In addition, Zn(II)-curc triggered p53 target gene expression in wild-type p53-carrying cells.	Zinc	13-19	tumor protein p53	Homo sapiens	75-78
26314369-10	2015	Taken together, our data indicate that Zn(II)-curc promotes the reactivation of p53 in thyroid cancer cells, providing in vitro evidence for a potential therapeutic approach in thyroid cancers.	Zinc	39-45	tumor protein p53	Homo sapiens	80-83
26258535-1	2015	Reduction of (4,0)-Ru2(chp)4Cl (1) (chp = 6-chloro-2-oxypyridinate) with Zn or FeCl2 yields a series of axial ligand adducts of the Ru2(II,II) species Ru2(chp)4(L), with L = tetrahydrofuran (2), dimethyl sulfoxide (DMSO; 3), PPh3 (4), pyridine (5), or MeCN (6).	Zinc	73-75	caveolin 1	Homo sapiens	225-229
26270157-5	2015	In this article, we investigate the reactivity of Zn CPF, a Zn(Cys)2(His)2 classical betabetaalpha zinc finger, with (1)O2.	Zinc	50-52	nuclear receptor subfamily 5 group A member 2	Homo sapiens	53-56
26270157-10	2015	Finally, Zn CPF is compared to Zn LTC, a treble clef Zn(Cys)4 zinc finger, to gain further insight into the behavior of zinc fingers toward (1)O2.	Zinc	9-11	nuclear receptor subfamily 5 group A member 2	Homo sapiens	12-15
25670850-12	2015	Additionally, Zn(ASA)2 significantly increased the mRNA-expression of superoxide dismutase 1 (+73 +- 15%), glutathione peroxidase 4 (+44 +- 12%), and transforming growth factor (TGF)-beta1 (+102 +- 22%).	Zinc	14-16	transforming growth factor, beta 1	Rattus norvegicus	150-188
26192046-6	2015	Also, the Zn(2+)vs. Cd(2+) discrimination for L1 and L2 is proved.	Zinc	10-12	L1 cell adhesion molecule	Homo sapiens	46-55
26112475-9	2015	Flow cytometric analyses showed that ELSPBP1-positive epididymosomes only interacted with dying or dead epididymal spermatozoa in a Zn 2 + -dependent manner.	Zinc	132-138	epididymal sperm binding protein 1	Bos taurus	37-44
26190227-9	2015	In addition, TPEN significantly inhibited the death and apoptosis of cells and attenuated the alteration of GluR2 and NR2 expression caused by OGD or OGD plus high Zn(2+) treatments.	Zinc	164-166	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	108-113
25670850-14	2015	The induction of antioxidant enzymes and the anti-inflammatory cytokine TGF-beta1 may play a pivotal role in the mechanism of action of Zn(ASA)2.	Zinc	136-138	transforming growth factor, beta 1	Rattus norvegicus	72-81
26286729-13	2015	In Zn-deficient esophagus, the miR-31 promoter region and NF-kappaBeta binding site were activated.	Zinc	3-5	nuclear factor kappa B subunit 1	Homo sapiens	58-70
26297485-0	2015	The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells.	Zinc	25-33	tumor protein p53	Homo sapiens	84-87
26297485-0	2015	The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells.	Zinc	25-33	tumor protein p53	Homo sapiens	112-115
26121325-0	2015	GLP-1 Receptor Mediated Targeting of a Fluorescent Zn(2+) Sensor to Beta Cell Surface for Imaging Insulin/Zn(2+) Release.	Zinc	51-53	insulin	Homo sapiens	98-105
25766674-5	2015	The aim of the current study was to determine if delivery of zinc (Zn) to SOD1 was also therapeutic.	Zinc	67-69	superoxide dismutase 1, soluble	Mus musculus	74-78
25766674-9	2015	In contrast, overall levels of Cu in the spinal cord were elevated in the Zn(II)(atsm)-treated SOD1G37R mice and the Cu content of SOD1 was also elevated.	Zinc	74-80	superoxide dismutase 1, soluble	Mus musculus	95-99
25766674-9	2015	In contrast, overall levels of Cu in the spinal cord were elevated in the Zn(II)(atsm)-treated SOD1G37R mice and the Cu content of SOD1 was also elevated.	Zinc	74-80	superoxide dismutase 1, soluble	Mus musculus	131-135
25766674-10	2015	Further experiments demonstrated transmetallation of Zn(II)(atsm) in the presence of Cu to form the Cu-analogue Cu(II)(atsm), indicating that the observed therapeutic effects for Zn(II)(atsm) in SOD1G37R mice may in fact be due to in vivo transmetallation and subsequent delivery of Cu.	Zinc	53-59	superoxide dismutase 1, soluble	Mus musculus	195-199
25766674-10	2015	Further experiments demonstrated transmetallation of Zn(II)(atsm) in the presence of Cu to form the Cu-analogue Cu(II)(atsm), indicating that the observed therapeutic effects for Zn(II)(atsm) in SOD1G37R mice may in fact be due to in vivo transmetallation and subsequent delivery of Cu.	Zinc	179-185	superoxide dismutase 1, soluble	Mus musculus	195-199
25959547-4	2015	Because Abeta interacts with Zn(2+) and Cu(2+), it is likely that these metal ions are involved in the Abeta-induced modification of the synaptic function.	Zinc	29-31	amyloid beta precursor protein	Homo sapiens	8-13
25860295-2	2015	This study found that bovine and human fibrinogen are heme-mediated ferritin-binding proteins and demonstrated direct binding of bovine ferritin to protoporphyrin (PPIX) and its derivatives or to Zn ions.	Zinc	196-198	fibrinogen beta chain	Homo sapiens	39-49
25959547-4	2015	Because Abeta interacts with Zn(2+) and Cu(2+), it is likely that these metal ions are involved in the Abeta-induced modification of the synaptic function.	Zinc	29-31	amyloid beta precursor protein	Homo sapiens	103-108
25959547-5	2015	There is evidence to indicate that the inhibition of the interaction of Abeta with Zn(2+) and Cu(2+) may ameliorate the pathophysiology of AD.	Zinc	83-85	amyloid beta precursor protein	Homo sapiens	72-77
25959547-6	2015	Interaction of extracellular Zn(2+) with Abeta in the hippocampus is involved in transiently Abeta-induced cognition deficits, while the interaction of extracellular Cu(2+) reduces bioavailability of intracellular Cu(2+), followed by an increase in oxidative stress, which may lead to cognitive deficits.	Zinc	29-31	amyloid beta precursor protein	Homo sapiens	41-46
25959547-6	2015	Interaction of extracellular Zn(2+) with Abeta in the hippocampus is involved in transiently Abeta-induced cognition deficits, while the interaction of extracellular Cu(2+) reduces bioavailability of intracellular Cu(2+), followed by an increase in oxidative stress, which may lead to cognitive deficits.	Zinc	29-31	amyloid beta precursor protein	Homo sapiens	93-98
25959547-7	2015	It is likely that Zn(2+) and Cu(2+) play as a key-mediating factor in pathophysiology of the synaptic dysfunction in which Abeta is involved.	Zinc	18-20	amyloid beta precursor protein	Homo sapiens	123-128
25872640-8	2015	To the best of our knowledge, the current study was the first to demonstrate that EGCG + Zn(2+) protects H9c2 cells against H/R injury through activation of the PI3K/Akt pathway, as determined by western blotting.	Zinc	89-91	AKT serine/threonine kinase 1	Rattus norvegicus	166-169
26155804-4	2015	The DP1-Zn-induced apoptotic pathways were characterized by the activation of caspases-3, -8, and -9, mitochondrial dysfunction, and reactive oxygen species (ROS) overproduction (305 +- 7.06% production of control at 250 mug/mL).	Zinc	8-10	caspase 3	Homo sapiens	78-100
26042713-9	2015	The proliferation of mesenchymal stem cells (MSCs) and their alkaline phosphatase activity (ALP) on GCs was revealed to be Zn-dose dependent with the highest performance being observed for 4 mol% ZnO.	Zinc	123-125	alkaline phosphatase, placental	Homo sapiens	92-95
26051901-1	2015	We report herein that Zn(II) selectively inhibits the hypoxia-inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II).	Zinc	22-28	egl-9 family hypoxia inducible factor 1	Homo sapiens	108-112
26203271-9	2015	LPS induced an increase in TNF-alpha and this response was further increased with -Zn.	Zinc	82-85	tumor necrosis factor	Mus musculus	27-36
26041778-3	2015	We reveal that Zn(2+) is a high affinity regulator of RyR2 displaying three modes of operation.	Zinc	15-17	ryanodine receptor 2	Homo sapiens	54-58
26041778-4	2015	Picomolar free Zn(2+) concentrations potentiate RyR2 responses, but channel activation is still dependent on the presence of cytosolic Ca(2+).	Zinc	15-21	ryanodine receptor 2	Homo sapiens	48-52
26041778-6	2015	Zn(2+) is therefore a higher affinity activator of RyR2 than Ca(2+).	Zinc	0-6	ryanodine receptor 2	Homo sapiens	51-55
26041778-9	2015	This highlights a new role for intracellular Zn(2+) in shaping Ca(2+) dynamics in cardiomyocytes through modulation of RyR2 gating.	Zinc	45-51	ryanodine receptor 2	Homo sapiens	119-123
24449189-7	2015	The data suggested that the high concentration of ZnS could induce dysfunction of VECs through decreasing caveolin-1 and elevation of the eNOS activity and thus present toxicity.	Zinc	50-53	caveolin 1	Homo sapiens	106-116
26087155-5	2015	There was a significant Zn levelxP source interaction on average daily gain and feed conversion ratio (FCR).	Zinc	24-26	FEEDCON	Sus scrofa	80-101
26087155-5	2015	There was a significant Zn levelxP source interaction on average daily gain and feed conversion ratio (FCR).	Zinc	24-26	FEEDCON	Sus scrofa	103-106
26070334-0	2015	Multifunctionality of Acidulated Serum Albumin on Inhibiting Zn2+-Mediated Amyloid beta-Protein Fibrillogenesis and Cytotoxicity.	Zinc	61-65	albumin	Homo sapiens	33-46
26070334-3	2015	In this study, we fabricated acidulated human serum albumin (A-HSA) as a multifunctional agent for binding Zn(2+) and modulating Zn(2+)-mediated Abeta fibrillogenesis and cytotoxicity.	Zinc	107-109	albumin	Homo sapiens	46-66
26070334-3	2015	In this study, we fabricated acidulated human serum albumin (A-HSA) as a multifunctional agent for binding Zn(2+) and modulating Zn(2+)-mediated Abeta fibrillogenesis and cytotoxicity.	Zinc	129-131	albumin	Homo sapiens	46-66
26013160-4	2015	Significantly, the transmetalation of Co(II) or Ni(II) on the Zn(II) centers in 446-MOF can enhance the sorption capacities of CO2 and CH4 (16-21%), whereas the impregnation of Eu(III) and Tb(III) in the channels of 446-MOF will result in adjustable light-emitting behaviors.	Zinc	62-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
25757458-4	2015	With increasing Zn concentrations, mRNA and protein levels of metallothionein (MT) and zinc transporter 1 (ZnT1) were upregulated, whereas zinc transporter 4 (ZIP4) expression was downregulated.	Zinc	16-18	solute carrier family 30 member 1	Sus scrofa	87-105
25757458-4	2015	With increasing Zn concentrations, mRNA and protein levels of metallothionein (MT) and zinc transporter 1 (ZnT1) were upregulated, whereas zinc transporter 4 (ZIP4) expression was downregulated.	Zinc	16-18	solute carrier family 30 member 1	Sus scrofa	107-111
25757458-5	2015	Metal-regulatory transcription factor-1 (MTF1) mRNA expression was upregulated at high Zn concentrations in IPEC-J2 cells, which corresponded to higher intracellular Zn concentrations.	Zinc	87-89	metal regulatory transcription factor 1	Sus scrofa	0-39
25757458-5	2015	Metal-regulatory transcription factor-1 (MTF1) mRNA expression was upregulated at high Zn concentrations in IPEC-J2 cells, which corresponded to higher intracellular Zn concentrations.	Zinc	87-89	metal regulatory transcription factor 1	Sus scrofa	41-45
25757458-5	2015	Metal-regulatory transcription factor-1 (MTF1) mRNA expression was upregulated at high Zn concentrations in IPEC-J2 cells, which corresponded to higher intracellular Zn concentrations.	Zinc	166-168	metal regulatory transcription factor 1	Sus scrofa	0-39
25757458-5	2015	Metal-regulatory transcription factor-1 (MTF1) mRNA expression was upregulated at high Zn concentrations in IPEC-J2 cells, which corresponded to higher intracellular Zn concentrations.	Zinc	166-168	metal regulatory transcription factor 1	Sus scrofa	41-45
25998829-1	2015	Seven Zn(II) coordination complexes with 5-halonicotinic acids (HL-X, X = F, Cl, or Br) have been synthesized with different synthetic approaches, including layer diffusion or stirring method in an ambient environment and solvothermal synthesis at 100  C. Assembly of HL-F with Zn(II) under different conditions will yield the same 2D network of [Zn(L-F)2]n (1).	Zinc	6-12	H2.0 like homeobox	Homo sapiens	64-68
25924885-6	2015	Ultimately, CdSe/CdS/ZnS QDs with peak emission at 630 nm were conjugated with Alexa Fluor 647-labeled peptide substrates for thrombin and immobilized on paper test strips inside the sample cells.	Zinc	21-24	coagulation factor II, thrombin	Homo sapiens	126-134
25895432-1	2015	The aim of the present study was to examine the association between intake of five common antioxidative nutrients from supplements and medications (vitamin E, vitamin C, carotenoids, Se, and Zn) and levels of high-sensitivity C-reactive protein (hs-CRP) in the general population.	Zinc	191-193	C-reactive protein	Homo sapiens	226-244
25653005-8	2015	These results imply that the downregulation of ZnT as well as the overexpression of ZIP transporters, in responses to the Zn depletion induced by Cd in the tissues of lactating rat and their offspring, play a major role in Cd accumulation and Zn redistribution in tissues of suckling rat.	Zinc	122-124	sequestosome 1	Rattus norvegicus	84-87
25803076-3	2015	Lysosomal ASM (L-ASM) is located within the lysosome, requires no additional Zn2+ ions for activation and is glycosylated mainly with high-mannose oligosaccharides.	Zinc	77-81	sphingomyelin phosphodiesterase 1	Homo sapiens	10-13
25803076-3	2015	Lysosomal ASM (L-ASM) is located within the lysosome, requires no additional Zn2+ ions for activation and is glycosylated mainly with high-mannose oligosaccharides.	Zinc	77-81	sphingomyelin phosphodiesterase 1	Homo sapiens	17-20
25803076-4	2015	By contrast, the secretory ASM (S-ASM) is located extracellularly, requires Zn2+ ions for activation, has a complex glycosylation pattern and has a longer in vivo half-life.	Zinc	76-80	sphingomyelin phosphodiesterase 1	Homo sapiens	27-30
25803076-4	2015	By contrast, the secretory ASM (S-ASM) is located extracellularly, requires Zn2+ ions for activation, has a complex glycosylation pattern and has a longer in vivo half-life.	Zinc	76-80	sphingomyelin phosphodiesterase 1	Homo sapiens	34-37
25902503-0	2015	Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I. Mitochondrial proton-pumping NADH:ubiquinone oxidoreductase (respiratory complex I) comprises more than 40 polypeptides and contains eight canonical FeS clusters.	Zinc	42-44	NADH:ubiquinone oxidoreductase subunit S6	Homo sapiens	16-22
25872526-7	2015	Of note, HG increased phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase (MAPK) pathways activation and Zn reversed HG-induced expression of PI3K/Akt, extracellular-signal-regulated kinase (ERK) and p38 MAPK, as well as EMT proteins.	Zinc	135-137	Eph receptor B1	Rattus norvegicus	182-219
25872526-7	2015	Of note, HG increased phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase (MAPK) pathways activation and Zn reversed HG-induced expression of PI3K/Akt, extracellular-signal-regulated kinase (ERK) and p38 MAPK, as well as EMT proteins.	Zinc	135-137	Eph receptor B1	Rattus norvegicus	221-224
25872526-9	2015	These results indicate that physiologically optimal levels of Zn can inhibit HG-induced EMT of the NRK-52E cells possibly through several mechanisms, including abrogation of HG-induced oxidative stress, and PI3K/Akt, p38 MAPK and ERK activation in NRK-52E cells.	Zinc	62-64	AKT serine/threonine kinase 1	Rattus norvegicus	212-215
25872526-9	2015	These results indicate that physiologically optimal levels of Zn can inhibit HG-induced EMT of the NRK-52E cells possibly through several mechanisms, including abrogation of HG-induced oxidative stress, and PI3K/Akt, p38 MAPK and ERK activation in NRK-52E cells.	Zinc	62-64	Eph receptor B1	Rattus norvegicus	230-233
25968625-1	2015	Dysfunctional interactions of amyloid-beta (Abeta) with Zn and Cu ions are proved to be related to the etiology of Alzheimer"s disease (AD).	Zinc	56-58	amyloid beta precursor protein	Homo sapiens	30-42
25968625-1	2015	Dysfunctional interactions of amyloid-beta (Abeta) with Zn and Cu ions are proved to be related to the etiology of Alzheimer"s disease (AD).	Zinc	56-58	amyloid beta precursor protein	Homo sapiens	44-49
25755079-8	2015	Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p &lt; 0.05).	Zinc	67-69	metallothionein 1A	Homo sapiens	5-9
25985359-2	2015	Based on considerable structural information obtained through ESI-MSn, all of the first transition metal ions (Fe2+, Co2+, Ni2+, Cu2+ and Zn2+) were found to form different complexes with quercetin, while with the number of chelating flavonoids decreasing along with the reduction of the metal ionic radius.	Zinc	138-142	moesin	Homo sapiens	66-69
25902503-2	2015	We show that the accessory NUMM subunit of complex I (human NDUFS6) harbors a Zn-binding site and resolve its position by X-ray crystallography.	Zinc	78-80	NADH:ubiquinone oxidoreductase subunit S6	Homo sapiens	60-66
25586622-9	2015	However, in the HT + Zn group, the histomorphology of the liver was restored, the serum aspartate aminotransferase (AST) level was significantly decreased, and the hepatic CuZn-SOD activity was significantly increased compared to the HT group.	Zinc	21-23	superoxide dismutase 1, soluble	Mus musculus	172-180
25586622-10	2015	Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group.	Zinc	97-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
25586622-10	2015	Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group.	Zinc	97-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
25586622-12	2015	Our results further suggest that Zn might exert its protective effects via the activation of the Nrf2-antioxidant pathway.	Zinc	33-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
25607980-0	2015	Nuclear-translocated endostatin downregulates hypoxia inducible factor-1alpha activation through interfering with Zn(II) homeostasis.	Zinc	114-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-77
25430013-0	2015	Ionome and expression level of Si transporter genes (Lsi1, Lsi2, and Lsi6) affected by Zn and Si interaction in maize.	Zinc	87-89	silicon transporter	Zea mays	59-63
25430013-11	2015	Expression level of Lsi1 and Lsi2 genes for the Si influx and efflux transporters was downregulated in roots after Si supply and even more downregulated by Zinc alone and also by Zn and Si interaction.	Zinc	179-181	silicon transporter	Zea mays	29-33
25691529-7	2015	Furthermore, in a mutant deleted of the Zn(II) exporter ZntA, they also trigger the expression of their target genes in response to either Zn(II), Cd(II), Pb(II), or Co(II).	Zinc	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25724285-6	2015	Zn and/or PQ augmented the expression of metallothionein-I and II and GSTA4-4.	Zinc	0-2	metallothionein 1	Rattus norvegicus	41-58
25710967-1	2015	p53 is a Zn(2+)-dependent tumor suppressor inactivated in &gt;50% of human cancers.	Zinc	9-11	tumor protein p53	Homo sapiens	0-3
25710967-6	2015	These [Zn(2+)]free levels are predicted to result in ~90% saturation of p53-R175H, thus accounting for its observed reactivation.	Zinc	7-13	tumor protein p53	Homo sapiens	72-75
25825723-3	2015	By applying a combination of NMR relaxation dispersion and fluorescence kinetics methods we have investigated quantitatively the thermodynamic Abeta-Zn(2+) binding features as well as how Zn(2+) modulates the nucleation mechanism of the aggregation process.	Zinc	149-151	amyloid beta precursor protein	Homo sapiens	143-148
25497982-3	2015	After thrombin-induced structure-switching DNA hairpins of probe 1, the DNAzyme is liberated from the caged structure, which hybridizes with the MB for cleavage of the MB in the presence of cofactor Zn(2+) and initiates the DNA recycling process, leading to the cleavage of a large number of MB and the generation of numerous primers for triggering RCA reaction.	Zinc	199-201	coagulation factor II, thrombin	Homo sapiens	6-14
25854540-11	2015	Most of these transformations proceed through low-valent cobalt complexes, which are conveniently generated in situ from air-stable Co(II) salts by Zn- or Mn-mediated reduction.	Zinc	148-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-138
25023609-0	2015	Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).	Zinc	104-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-27
25635913-13	2015	Thus, similar to bacterial agmatinases and some of the antibiotic-degrading, Zn(2+)-dependent metallo-beta-lactamases ALP appears to be active in the mono and binuclear form, with binding of the second metal ion increasing both reactivity and stability.	Zinc	77-83	asparaginase and isoaspartyl peptidase 1	Homo sapiens	118-121
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Zinc	72-74	interleukin 6	Homo sapiens	116-120
25366467-5	2015	Regarding enzymatic activities, Zn only provoked pronounced increases in the ascorbate peroxidase activity in maize at the early exposure times and occasionally in the superoxide dismutase (14 days) and catalase (7 and 35 days) activities in wheat.	Zinc	32-34	peroxidase 1	Zea mays	87-97
25467853-1	2015	Methionine synthase (MS) and betaine-homocysteine methyltransferase (BHMT) are both zinc (Zn)-dependent methyltransferases and involved in the methylation of homocysteine.	Zinc	90-92	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	0-19
25467853-1	2015	Methionine synthase (MS) and betaine-homocysteine methyltransferase (BHMT) are both zinc (Zn)-dependent methyltransferases and involved in the methylation of homocysteine.	Zinc	90-92	betaine-homocysteine S-methyltransferase	Rattus norvegicus	29-67
25467853-1	2015	Methionine synthase (MS) and betaine-homocysteine methyltransferase (BHMT) are both zinc (Zn)-dependent methyltransferases and involved in the methylation of homocysteine.	Zinc	90-92	betaine-homocysteine S-methyltransferase	Rattus norvegicus	69-73
25641898-8	2015	To obtain biological insight into Zn and Fe cross-talk, we focused on transporters, where STP4 and STP13 sugar transporters were predominantly expressed and responsive to Fe-deficient conditions.	Zinc	34-36	sugar transporter 4	Arabidopsis thaliana	90-94
25641898-8	2015	To obtain biological insight into Zn and Fe cross-talk, we focused on transporters, where STP4 and STP13 sugar transporters were predominantly expressed and responsive to Fe-deficient conditions.	Zinc	34-36	Major facilitator superfamily protein	Arabidopsis thaliana	99-104
25366568-6	2015	Moreover, the results obtained of using potent inhibitors of Abeta cation channels such as Zn(2+) and the small peptide NA7 add further proof to the suggestion that the long-term increases in cytosolic [Ca(2+)] in cells stressed by continuous exposure to Abeta is the result of Abeta ion channel activity.	Zinc	91-93	amyloid beta precursor protein	Homo sapiens	61-66
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Zinc	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25408502-8	2015	The pro-apoptotic effects of Zn(2+) -chelation in combination with F10 treatment were enhanced by inhibiting Omi/HtrA2 implicating this serine protease as a novel target for prostate cancer treatment.	Zinc	29-31	coagulation factor II, thrombin	Homo sapiens	136-151
25475532-2	2015	This change in AMPAR subunit composition leads to an increase in surface expression of GluA2-lacking Ca(2+) /Zn(2+) permeable AMPARs.	Zinc	109-115	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
25475532-2	2015	This change in AMPAR subunit composition leads to an increase in surface expression of GluA2-lacking Ca(2+) /Zn(2+) permeable AMPARs.	Zinc	109-115	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	87-92
25475532-2	2015	This change in AMPAR subunit composition leads to an increase in surface expression of GluA2-lacking Ca(2+) /Zn(2+) permeable AMPARs.	Zinc	109-115	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-132
25408502-10	2015	The serine protease Omi/HtrA2 modulates Zn(2+) -dependent apoptosis in prostate cancer cells and represents a new target for treatment of CRPC.	Zinc	40-46	coagulation factor II, thrombin	Homo sapiens	4-19
25549802-0	2015	Unusual Zn(II) Affinities of Zinc Fingers of Poly(ADP-ribose)Polymerase 1 (PARP-1) Nuclear Protein.	Zinc	8-10	poly(ADP-ribose) polymerase 1	Homo sapiens	45-73
25549802-0	2015	Unusual Zn(II) Affinities of Zinc Fingers of Poly(ADP-ribose)Polymerase 1 (PARP-1) Nuclear Protein.	Zinc	8-10	poly(ADP-ribose) polymerase 1	Homo sapiens	75-81
25549802-3	2015	Using spectroscopic methods and competitive titrations with Zn(II), Co(II), and Ni(II) ions, we determined conditional dissociation constants for Zn(II) complexes of PARPzf1 and PARPzf2 at pH 7.4 (HEPESbuffer) as 26 +- 4 nM and 4 +- 1 pM, respectively.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
25173731-3	2015	Under visible light irradiation, the AChE-CdSe@ZnS/graphene nanocomposite can generate a stable photocurrent and the photocurrent is found to be inversely dependent on the concentration of OPs.	Zinc	47-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-41
25594823-7	2015	Furthermore, the obtained ZAIS/ZnS nanocompounds (NCs) were covalently conjugated to alpha-fetoprotein antibodies and targeted fluorescent imaging for hepatocellular carcinoma cells was realized.	Zinc	31-34	alpha fetoprotein	Homo sapiens	85-102
25173731-2	2015	The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform.	Zinc	24-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-89
25173731-2	2015	The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform.	Zinc	24-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
25597800-0	2015	Development of gold nanoparticle based colorimetric method for quantitatively studying the inhibitors of Cu(2+)/Zn(2+) induced beta-amyloid peptide assembly.	Zinc	112-114	amyloid beta precursor protein	Homo sapiens	127-147
25717359-3	2015	We report biophysical and kinetic studies on the Sao Paulo MBL (SPM-1), which reveal its Zn(ii) ion usage and mechanism as characteristic of the clinically important di-Zn(ii) dependent B1 MBL subfamily.	Zinc	89-95	mannose-binding lectin family member 3, pseudogene	Homo sapiens	59-62
25717359-3	2015	We report biophysical and kinetic studies on the Sao Paulo MBL (SPM-1), which reveal its Zn(ii) ion usage and mechanism as characteristic of the clinically important di-Zn(ii) dependent B1 MBL subfamily.	Zinc	89-95	mannose-binding lectin family member 3, pseudogene	Homo sapiens	189-192
25597800-1	2015	In this paper, a kind of gold nanoparticle (GNP)-based colorimetric assay has been developed for studying the reversible interaction of beta-amyloid peptide (Abeta) with Cu(2+) and Zn(2+), and quantitatively analyzing four inhibitors (i.e., EDTA, EGTA, histidine and clioquinol) of Cu(2+)/Zn(2+) induced Abeta assembly.	Zinc	181-183	amyloid beta precursor protein	Homo sapiens	136-156
25597800-1	2015	In this paper, a kind of gold nanoparticle (GNP)-based colorimetric assay has been developed for studying the reversible interaction of beta-amyloid peptide (Abeta) with Cu(2+) and Zn(2+), and quantitatively analyzing four inhibitors (i.e., EDTA, EGTA, histidine and clioquinol) of Cu(2+)/Zn(2+) induced Abeta assembly.	Zinc	289-291	amyloid beta precursor protein	Homo sapiens	136-156
25413880-9	2015	Therefore, Zn deficiency resulted in insulin resistance through iron overload.	Zinc	11-13	insulin	Homo sapiens	37-44
25482915-2	2015	The receptor shows a high sensitivity and selectivity for Zn(2+) through a "turn-on" fluorescence response over the other tested cations with a detection limit as low as 0.67 muM.	Zinc	58-60	latexin	Homo sapiens	175-178
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-166
25649462-3	2015	Since Zn(2+) concentration determines insulin oligomer equilibrium, we computationally investigated interactions of IAPP with different insulin oligomers and compared with IAPP homodimer formation.	Zinc	6-12	insulin	Homo sapiens	38-45
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	caspase 9	Rattus norvegicus	128-137
25541535-7	2015	Notably, maternal dietary organic Zn exposure exhibited greater attenuation of gut impairment, along with increased MUC2 expression and sIgA level, and decreased the abundance of TNF-alpha and A20 relative to the inorganic-Zn group.	Zinc	34-36	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	116-120
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	caspase 6	Rattus norvegicus	167-176
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	caspase 7	Rattus norvegicus	181-190
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	BCL2, apoptosis regulator	Rattus norvegicus	215-220
25201908-7	2015	The CPCs with ZnBG showed increased ALP activity, enhanced formation of mineralized nodules, and upregulated mRNA expression of DMP-1, DSPP, Runx2, and osterix in a time- and dose-dependent manner, relative to CPCs without Zn.	Zinc	14-16	RUNX family transcription factor 2	Homo sapiens	141-146
25381639-8	2015	Further, gene expressions of caspase 3 and caspase 9 were also found to be elevated after Al treatment, which however were reduced following Zn co-treatment.	Zinc	141-143	caspase 9	Rattus norvegicus	43-52
25548200-9	2015	Metallothionein (MT) mRNA levels of broilers fed the diet supplemented with 80 mg/kg Zn from Zn-ZCP or ZnSO4 was higher (P &lt; 0.05) than that in the control group.	Zinc	85-87	metallothionein 4	Gallus gallus	0-15
25554447-2	2015	Correct metal insertion during SOD1 biosynthesis is critical to prevent misfolding; however Zn(2+) can bind to the copper-site leading to an aberrantly metallated protein.	Zinc	92-94	superoxide dismutase 1	Homo sapiens	31-35
25554447-3	2015	These effects of Zn(2+) misligation on SOD1 aggregation remain to be explored, even though Zn(2+) levels are upregulated in ALS motor neurons.	Zinc	17-23	superoxide dismutase 1	Homo sapiens	39-43
25492176-0	2015	In vitro degradation and electrochemical corrosion evaluations of microarc oxidized pure Mg, Mg-Ca and Mg-Ca-Zn alloys for biomedical applications.	Zinc	109-111	attractin	Homo sapiens	103-108
25554447-4	2015	Here we use complementary biophysical methods to investigate Zn(2+) binding and its effects on the aggregation of three immature metal-free SOD1 conformers that represent biogenesis intermediates: dimeric, monomeric and reduced monomeric SOD1.	Zinc	61-63	superoxide dismutase 1	Homo sapiens	140-144
25554447-9	2015	Transmission electron microscopy reveals that Zn(2+) diverts the SOD1 aggregation pathway from fibrils to amorphous aggregate, and electrophoretic analysis evidences an increase in insoluble materials.	Zinc	46-48	superoxide dismutase 1	Homo sapiens	65-69
25678741-10	2015	The P(O)OH groups maintain their ability to bind metal ions within the HAP matrix: contacting the modified HAP with 10-4 N nitrate solutions of five transition metal ions gives an affinity sequence of Pb(II) &gt; Cd(II) &gt; Zn(II) &gt; Ni(II) &gt; Cu(II).	Zinc	225-227	submaxillary gland androgen regulated protein 3B	Homo sapiens	201-207
25620235-8	2015	Injection of TNFalpha, a potent activator of early involution, into the mammary gland fat pads of lactating mice increased ZnT2 and Zn in lysosomes and activated premature involution.	Zinc	123-125	tumor necrosis factor	Mus musculus	13-21
25620235-9	2015	Exposure of cultured MECs to TNFalpha redistributed ZnT2 to lysosomes and increased lysosomal Zn, which activated lysosomal swelling, cathepsin B release, and LCD.	Zinc	52-54	tumor necrosis factor	Mus musculus	29-37
25685664-0	2015	Diffuse binding of Zn(2+) to the denatured ensemble of Cu/Zn superoxide dismutase 1.	Zinc	19-21	superoxide dismutase 1	Homo sapiens	61-83
25685664-2	2015	Native SOD1 monomers coordinate one structural Zn(2+) and one redox-active Cu(2+/1+) to the active site.	Zinc	47-49	superoxide dismutase 1	Homo sapiens	7-11
25685664-3	2015	To do this, the Zn(2+) ions need to interact with the SOD1 protein on the denatured side of the folding barrier, prior to the formation of the folding nucleus.	Zinc	16-18	superoxide dismutase 1	Homo sapiens	54-58
25685664-4	2015	In this study, we have examined at residue level the nature of this early Zn(2+) binding by NMR studies on the urea denatured-state of SOD1.	Zinc	74-76	superoxide dismutase 1	Homo sapiens	135-139
25685664-7	2015	Chemical-shift changes upon Zn(2+) titration show that denatured SOD1 retains a significant affinity to Zn(2+) ions, even in 9 M urea.	Zinc	28-30	superoxide dismutase 1	Homo sapiens	65-69
25685664-7	2015	Chemical-shift changes upon Zn(2+) titration show that denatured SOD1 retains a significant affinity to Zn(2+) ions, even in 9 M urea.	Zinc	104-106	superoxide dismutase 1	Homo sapiens	65-69
25685664-10	2015	The result suggests that the Zn(2+)-binding observed to catalyze folding of SOD1 in physiological buffer is initiated by diffuse, non-specific coordination to the coil, which subsequently funnels by ligand exchange into the native coordination geometry of the folded monomer.	Zinc	29-35	superoxide dismutase 1	Homo sapiens	76-80
25427234-3	2014	We report the crystal structure of Dug1p at 2.55 A resolution in complex with a Gly-Cys dipeptide and two Zn(2+) ions.	Zinc	106-108	metallodipeptidase	Saccharomyces cerevisiae S288C	35-40
25128098-4	2015	The adsorption capacity of CS-B for metal ions Co(2+), Hg(2+), Cu(2+), Zn(2+), and Pb(2+) from aqueous systems at different pH values showed various levels of efficiency.	Zinc	71-73	chorionic somatomammotropin hormone 2	Homo sapiens	27-31
25227315-6	2015	MFAO effects on Abeta:Zn complex formation were evaluated with Zinquin staining and the ability of the Abeta:Zn complex to be degraded by matrix metalloproteinase-2 (MMP-2).	Zinc	22-24	amyloid beta precursor protein	Homo sapiens	16-21
25227315-6	2015	MFAO effects on Abeta:Zn complex formation were evaluated with Zinquin staining and the ability of the Abeta:Zn complex to be degraded by matrix metalloproteinase-2 (MMP-2).	Zinc	109-111	amyloid beta precursor protein	Homo sapiens	103-108
25227315-11	2015	MFAOs also removed zinc from the Abeta:Zn complex so that Abeta plaque could be degraded by MMP-2.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	33-38
25227315-11	2015	MFAOs also removed zinc from the Abeta:Zn complex so that Abeta plaque could be degraded by MMP-2.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	58-63
26764306-6	2015	When Zn(ii) was added to the insulin sample the same oligomers were observed but with 0-6 Zn(ii) ions bound to each of the oligomers.	Zinc	5-11	insulin	Homo sapiens	29-36
26764306-8	2015	Insulin oligomers of band I dissociated primarily by releasing either the 2+ or 3+ monomer accompanied by an oligomer that conserved the mass, charge and Zn(ii) of the precursor.	Zinc	154-156	insulin	Homo sapiens	0-7
26764306-9	2015	Insulin oligomers of bands II and III dissociated primarily by releasing the 2+ monomer accompanied by an oligomer which conserved the mass, charge and Zn(ii) of the precursor.	Zinc	152-158	insulin	Homo sapiens	0-7
25818846-5	2015	AREAS COVERED: This paper gives an overview of the interaction between Abeta and Zn(2+) in the extracellular compartment in the pathophysiology of AD.	Zinc	81-83	amyloid beta precursor protein	Homo sapiens	71-76
25818846-6	2015	Abeta is aggregated with Zn(2+) and the aggregation of Abeta-peptides is widely considered to be the critical step in the pathogenesis of AD.	Zinc	25-27	amyloid beta precursor protein	Homo sapiens	0-5
25818846-9	2015	EXPERT OPINION: Recent studies show that the inhibition of the interaction of Abeta with extracellular Zn(2+) ameliorates the pathophysiology of AD and that extracellular Zn(2+) in the hippocampus is involved in transiently Abeta-induced cognition deficits.	Zinc	103-105	amyloid beta precursor protein	Homo sapiens	78-83
25818846-9	2015	EXPERT OPINION: Recent studies show that the inhibition of the interaction of Abeta with extracellular Zn(2+) ameliorates the pathophysiology of AD and that extracellular Zn(2+) in the hippocampus is involved in transiently Abeta-induced cognition deficits.	Zinc	103-105	amyloid beta precursor protein	Homo sapiens	224-229
25818846-9	2015	EXPERT OPINION: Recent studies show that the inhibition of the interaction of Abeta with extracellular Zn(2+) ameliorates the pathophysiology of AD and that extracellular Zn(2+) in the hippocampus is involved in transiently Abeta-induced cognition deficits.	Zinc	171-173	amyloid beta precursor protein	Homo sapiens	224-229
25568367-21	2015	Expression of IL-1beta decreased (linear, P = 0.026) in the mucosa of pigs fed increasing added Zn.	Zinc	96-98	interleukin-1 beta	Sus scrofa	14-22
25568367-23	2015	Also, additional Zn increased plasma Zn and reduced IL-1beta.	Zinc	17-19	interleukin-1 beta	Sus scrofa	52-60
26707039-2	2015	Familial amyotrophic lateral sclerosis (ALS) are caused by the mutations in the copper (Cu) / zinc (Zn) superoxide dismutase 1 (SOD1) gene.	Zinc	100-102	superoxide dismutase 1	Homo sapiens	104-126
26707039-2	2015	Familial amyotrophic lateral sclerosis (ALS) are caused by the mutations in the copper (Cu) / zinc (Zn) superoxide dismutase 1 (SOD1) gene.	Zinc	100-102	superoxide dismutase 1	Homo sapiens	128-132
26163782-1	2015	Some new complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Fe(III) with the Schiff base 5-chloro-2-(furan-2-yl methylamino)phenyl)phenyl methanone has been synthesized and characterized by elemental analysis, spectroscopic data including FT-IR, (1)H NMR, Electronic, ESI mass, Mossbauer &amp; ESR.	Zinc	54-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
26163785-6	2015	The Mn(II), Co(II), Ni(II) and Cu(II) complexes have been assigned a monomeric octahedral geometry whereas tetrahedral to Zn(II) and Cd(II) complexes.	Zinc	122-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
25137638-5	2014	The conserved turn structure at Val24-Lys28 in all peptides and Zn2+-bound Abeta42 is confirmed as the common structural motif to nucleate folding of Abeta.	Zinc	64-68	amyloid beta precursor protein	Homo sapiens	75-80
25083917-8	2014	The changes are more radical and different in the D124N Zn-less mutant than in the Zn-less WT-SOD1, suggesting D124N being perhaps not the most adequate model for Zn-less SOD1.	Zinc	83-85	superoxide dismutase 1	Homo sapiens	94-98
25083917-8	2014	The changes are more radical and different in the D124N Zn-less mutant than in the Zn-less WT-SOD1, suggesting D124N being perhaps not the most adequate model for Zn-less SOD1.	Zinc	83-85	superoxide dismutase 1	Homo sapiens	94-98
25083917-10	2014	Thus, the role of Zn in SOD1 is not just structural, as was previously thought; it is a vital part of the catalytic machinery.	Zinc	18-20	superoxide dismutase 1	Homo sapiens	24-28
25499498-2	2014	Only BTF1 was fed with Tween-20 and Zn(II).	Zinc	36-42	butyrophilin subfamily 2 member A1	Homo sapiens	5-9
25536033-1	2014	We examined an idea that short-term cognition is transiently affected by a state of confusion in Zn2+ transport system due to a local increase in amyloid-beta (Abeta) concentration.	Zinc	97-101	amyloid beta precursor protein	Homo sapiens	160-165
25536033-4	2014	Abeta-mediated impairments of LTP and memory were rescued in the presence of zinc chelators, suggesting that Zn2+ is involved in Abeta action.	Zinc	109-113	amyloid beta precursor protein	Homo sapiens	0-5
25536033-4	2014	Abeta-mediated impairments of LTP and memory were rescued in the presence of zinc chelators, suggesting that Zn2+ is involved in Abeta action.	Zinc	109-113	amyloid beta precursor protein	Homo sapiens	129-134
25536033-5	2014	When Abeta was injected into the dentate gyrus, intracellular Zn2+ levels were increased only in the injected area in the dentate gyrus, suggesting that Abeta induces the influx of Zn2+ into cells in the injected area.	Zinc	62-66	amyloid beta precursor protein	Homo sapiens	5-10
25536033-5	2014	When Abeta was injected into the dentate gyrus, intracellular Zn2+ levels were increased only in the injected area in the dentate gyrus, suggesting that Abeta induces the influx of Zn2+ into cells in the injected area.	Zinc	62-66	amyloid beta precursor protein	Homo sapiens	153-158
25536033-5	2014	When Abeta was injected into the dentate gyrus, intracellular Zn2+ levels were increased only in the injected area in the dentate gyrus, suggesting that Abeta induces the influx of Zn2+ into cells in the injected area.	Zinc	181-185	amyloid beta precursor protein	Homo sapiens	5-10
25536033-5	2014	When Abeta was injected into the dentate gyrus, intracellular Zn2+ levels were increased only in the injected area in the dentate gyrus, suggesting that Abeta induces the influx of Zn2+ into cells in the injected area.	Zinc	181-185	amyloid beta precursor protein	Homo sapiens	153-158
25536033-8	2014	The present study indicates that Abeta-mediated Zn2+ influx into dentate granule cells, which may occur without AMPA receptor activation, transiently induces a short-term cognitive deficit.	Zinc	48-52	amyloid beta precursor protein	Homo sapiens	33-38
25536033-9	2014	Extracellular Zn2+ may play a key role for transiently Abeta-induced cognition deficits.	Zinc	14-18	amyloid beta precursor protein	Homo sapiens	55-60
25446533-0	2014	Zn2+-stimulation of sperm capacitation and of the acrosome reaction is mediated by EGFR activation.	Zinc	0-4	epidermal growth factor receptor	Homo sapiens	83-87
25446533-7	2014	We show here that Zn(2+) activates the EGFR during sperm capacitation, which is mediated by activation of trans-membrane adenylyl cyclase (tmAC), protein kinase A (PKA), and the tyrosine kinase, Src.	Zinc	18-24	epidermal growth factor receptor	Homo sapiens	39-43
25446533-7	2014	We show here that Zn(2+) activates the EGFR during sperm capacitation, which is mediated by activation of trans-membrane adenylyl cyclase (tmAC), protein kinase A (PKA), and the tyrosine kinase, Src.	Zinc	18-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	195-198
25446533-8	2014	Moreover, the addition of Zn(2+) to capacitated sperm caused further stimulation of EGFR and phosphatydil-inositol-3-kinase (PI3K) phosphorylation, leading to the AR.	Zinc	26-28	epidermal growth factor receptor	Homo sapiens	84-88
25446533-10	2014	The AR stimulated by Zn(2+) is mediated by GPR39 receptor, PKA, Src and the EGFR, as well as the EGFR down-stream effectors PI3K, phospholipase C (PLC) and protein kinase C (PKC).	Zinc	21-23	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	64-67
25446533-10	2014	The AR stimulated by Zn(2+) is mediated by GPR39 receptor, PKA, Src and the EGFR, as well as the EGFR down-stream effectors PI3K, phospholipase C (PLC) and protein kinase C (PKC).	Zinc	21-23	epidermal growth factor receptor	Homo sapiens	76-80
25083917-2	2014	The mechanism of SOD1 misfolding is thought to involve mutations leading to the loss of Zn, followed by protein unfolding and aggregation.	Zinc	88-90	superoxide dismutase 1	Homo sapiens	17-21
25083917-3	2014	We show that the removal of Zn from SOD1 may not lead to an immediate unfolding but immediately deactivates the enzyme through a combination of subtle structural and electronic effects.	Zinc	28-30	superoxide dismutase 1	Homo sapiens	36-40
25083917-4	2014	Using quantum mechanics/discrete molecular dynamics, we showed that both Zn-less wild-type (WT)-SOD1 and its D124N mutant that does not bind Zn have at least metastable folded states.	Zinc	73-75	superoxide dismutase 1	Homo sapiens	96-100
25083917-7	2014	However, even without the full reduction to Cu(I), the Cu site in the Zn-less variants of SOD1 is shown to be catalytically incompetent: unable to bind superoxide in a way comparable to the WT-SOD1.	Zinc	70-72	superoxide dismutase 1	Homo sapiens	90-94
25083917-7	2014	However, even without the full reduction to Cu(I), the Cu site in the Zn-less variants of SOD1 is shown to be catalytically incompetent: unable to bind superoxide in a way comparable to the WT-SOD1.	Zinc	70-72	superoxide dismutase 1	Homo sapiens	193-197
25270168-8	2014	Bone resorption, TRAP(+) cells and expression of Tnfa, Il10 and Runx2 were significantly diminished in 5-LO(-/-), ZN- and MT-treated mice.	Zinc	114-116	tumor necrosis factor	Mus musculus	49-53
25270168-8	2014	Bone resorption, TRAP(+) cells and expression of Tnfa, Il10 and Runx2 were significantly diminished in 5-LO(-/-), ZN- and MT-treated mice.	Zinc	114-116	interleukin 10	Mus musculus	55-59
24889867-5	2014	Under these conditions, Cathepsin L was also proved to interact with cystatin B, being also modulated by physiological concentrations of Cu(++) , Fe(++) and Zn(++) .	Zinc	157-163	cathepsin L	Homo sapiens	24-35
24889867-5	2014	Under these conditions, Cathepsin L was also proved to interact with cystatin B, being also modulated by physiological concentrations of Cu(++) , Fe(++) and Zn(++) .	Zinc	157-163	cystatin B	Homo sapiens	69-79
25137638-8	2014	We characterize the different populations of correlated domain motions for each mutant from a more macroscopic perspective, and unexpectedly find that Zn2+-bound Abeta42 ensemble shares the same populations as Abeta42, indicating that the binding of Zn2+ to Abeta follows the conformational selection mechanism, and thus is independent of domain motions, even though the structures of Abeta have been modified at a residue level.	Zinc	151-155	amyloid beta precursor protein	Homo sapiens	162-167
25137638-8	2014	We characterize the different populations of correlated domain motions for each mutant from a more macroscopic perspective, and unexpectedly find that Zn2+-bound Abeta42 ensemble shares the same populations as Abeta42, indicating that the binding of Zn2+ to Abeta follows the conformational selection mechanism, and thus is independent of domain motions, even though the structures of Abeta have been modified at a residue level.	Zinc	250-254	amyloid beta precursor protein	Homo sapiens	162-167
25137638-8	2014	We characterize the different populations of correlated domain motions for each mutant from a more macroscopic perspective, and unexpectedly find that Zn2+-bound Abeta42 ensemble shares the same populations as Abeta42, indicating that the binding of Zn2+ to Abeta follows the conformational selection mechanism, and thus is independent of domain motions, even though the structures of Abeta have been modified at a residue level.	Zinc	250-254	amyloid beta precursor protein	Homo sapiens	210-215
24841088-6	2014	As a result, Zn(2+) was released from the surface of QDs, and the Lyz-QDs complexes were formed to quench the QDs PL.	Zinc	13-15	lysozyme	Homo sapiens	66-69
25360823-4	2014	For HDAC1/2/3 selective-inhibitor benzamide, the conserved tyrosine could modulate the coordinative ability of the central atom (Zn(2+)), while for pan-inhibitor SAHA, the conserved tyrosine could increase the chelating ability of the ligand (SAHA).	Zinc	129-135	histone deacetylase 1	Homo sapiens	4-13
25361206-0	2014	Electrogenerated chemiluminescence resonance energy transfer between luminol and CdSe@ZnS quantum dots and its sensing application in the determination of thrombin.	Zinc	86-89	coagulation factor II, thrombin	Homo sapiens	155-163
25301772-6	2014	The effect of metal ions on the binding constants of fluconazole-HSA complex suggested that the presence of Mg(2+) and Zn(2+) ions could decrease the free drug level and extend the half-life in the systematic circulation.	Zinc	119-121	albumin	Homo sapiens	65-68
25517751-4	2014	In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B.	Zinc	30-32	microRNA 214	Homo sapiens	52-59
25350745-11	2014	There was no change in ZIP1 mRNA levels by TPEN but a significant 3-fold increase in expression of another influx transporter ZIP2, consistent with a role for ZIP2 in maintaining macrophage Zn levels.	Zinc	190-192	solute carrier family 39 member 2	Homo sapiens	126-130
24941465-7	2014	FROM THE CLINICAL EDITOR: This study demonstrates carcinoembryonic antigen imaging on normal human appendix and colon carcinoma tissue utilizing CdSe/ZnS quantum dots conjugated to streptavidin or to 13-kDa single-domain antibodies as efficient two-photon excitation probes.	Zinc	150-153	CEA cell adhesion molecule 3	Homo sapiens	50-74
25096900-5	2014	Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR.	Zinc	143-145	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
25350745-11	2014	There was no change in ZIP1 mRNA levels by TPEN but a significant 3-fold increase in expression of another influx transporter ZIP2, consistent with a role for ZIP2 in maintaining macrophage Zn levels.	Zinc	190-192	solute carrier family 39 member 2	Homo sapiens	159-163
25160825-4	2014	One-pot electrophilic substitution of the C(sp2)-Zn bond by Cu(I)-mediated C-C bond formation and subsequent manipulation of the C(sp2)-Si bond provides a modular access to Z-alpha,beta-disubstituted enamides.	Zinc	49-51	Sp2 transcription factor	Homo sapiens	42-47
25374537-2	2014	In contrast, this study used a late-onset AD model to examine the interaction between increased dietary zinc (Zn) and the apolipoprotein E (ApoE) gene.	Zinc	110-112	apolipoprotein E	Mus musculus	122-138
25374537-3	2014	ApoE epsilon4 is overrepresented in late-onset AD and enhances Zn binding to amyloid-beta (Abeta).	Zinc	63-65	apolipoprotein E	Mus musculus	0-4
25248492-2	2014	Inherently phosphorescence-attenuated Mn-doped ZnS QDs were prepared with electron transfer protein cytochrome C (Cyt C) as the ligand, which was capable of protease sensing in both label-free and activable format.	Zinc	47-50	cytochrome c, somatic	Homo sapiens	100-112
25248492-2	2014	Inherently phosphorescence-attenuated Mn-doped ZnS QDs were prepared with electron transfer protein cytochrome C (Cyt C) as the ligand, which was capable of protease sensing in both label-free and activable format.	Zinc	47-50	cytochrome c, somatic	Homo sapiens	114-119
25160825-4	2014	One-pot electrophilic substitution of the C(sp2)-Zn bond by Cu(I)-mediated C-C bond formation and subsequent manipulation of the C(sp2)-Si bond provides a modular access to Z-alpha,beta-disubstituted enamides.	Zinc	49-51	Sp2 transcription factor	Homo sapiens	129-134
25162517-4	2014	In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1.	Zinc	147-149	solute carrier family 30 member 1	Homo sapiens	227-232
25142338-4	2014	[Zn(Imdz)(2) R - OH(2)](2+) complexes (Imdz =imidazole rings; R = imidazole ring, acetic acid molecule or acetate anion) were used to partially reproduce the coordination sphere in metalloproteases (ACE, amgiotensin converting enzyme, and TLN, thermolysine) being inhibited by related compounds (i.e., silanediols).	Zinc	1-3	angiotensin I converting enzyme	Homo sapiens	199-202
24951051-4	2014	In the present study, based on the 3D crystal structure of the ZnT-1 homologue, YiiP, that predicts a homodimer that utilizes the H(+) electrochemical gradient to facilitate Zn(2+) efflux, we demonstrate ZnT-1 dependent Zn(2+) efflux from HEK 293T cells using FluoZin-3 and Fura 2 by single cell microscope based fluorescent imaging.	Zinc	63-65	solute carrier family 30 member 1	Homo sapiens	204-209
24951051-4	2014	In the present study, based on the 3D crystal structure of the ZnT-1 homologue, YiiP, that predicts a homodimer that utilizes the H(+) electrochemical gradient to facilitate Zn(2+) efflux, we demonstrate ZnT-1 dependent Zn(2+) efflux from HEK 293T cells using FluoZin-3 and Fura 2 by single cell microscope based fluorescent imaging.	Zinc	174-176	solute carrier family 30 member 1	Homo sapiens	63-68
24951051-4	2014	In the present study, based on the 3D crystal structure of the ZnT-1 homologue, YiiP, that predicts a homodimer that utilizes the H(+) electrochemical gradient to facilitate Zn(2+) efflux, we demonstrate ZnT-1 dependent Zn(2+) efflux from HEK 293T cells using FluoZin-3 and Fura 2 by single cell microscope based fluorescent imaging.	Zinc	174-176	solute carrier family 30 member 1	Homo sapiens	204-209
24951051-6	2014	Moreover, substitution of two amino acids in the putative zinc binding domain of ZnT-1 led to nullification of Zn(2+) efflux and rendered the mutated protein incapable of protecting cells against Zn(2+) toxicity.	Zinc	111-113	solute carrier family 30 member 1	Homo sapiens	81-86
24944024-3	2014	In this context, S100A12 is of special interest because it is a pro-inflammatory protein expressed in neutrophils whose structure and function are modulated by both Ca(2+) and Zn(2+).	Zinc	176-178	S100 calcium binding protein A12	Homo sapiens	17-24
24944024-6	2014	In this work we use molecular dynamics simulations to describe how variations in Zn(2+) and Ca(2+) concentrations modulate the structural dynamics of the calcium-free S100A12 dimer and monomer, which was not considered a part of the mechanism of action before.	Zinc	81-87	S100 calcium binding protein A12	Homo sapiens	167-174
25141099-6	2014	Aluminium treatment significantly elevated the levels of lipid peroxidation and reactive oxygen species as well as the activities of catalase, superoxide dismutase and glutathione reductase, which however were decreased following Zn co-treatment of Al-treated rats.	Zinc	230-232	catalase	Rattus norvegicus	133-141
25052939-4	2014	The binding of a single Zn(2+) to mutant SOD1 lowered its net charge by an additional +2.33 +- 0.01 to +3.18 +- 0.02 units, however, each protein regulated net charge when binding a second, third, or fourth Zn(2+) (DeltaZ < 0.44 +- 0.07 per additional Zn(2+) ).	Zinc	24-26	superoxide dismutase 1	Homo sapiens	41-45
25052939-4	2014	The binding of a single Zn(2+) to mutant SOD1 lowered its net charge by an additional +2.33 +- 0.01 to +3.18 +- 0.02 units, however, each protein regulated net charge when binding a second, third, or fourth Zn(2+) (DeltaZ < 0.44 +- 0.07 per additional Zn(2+) ).	Zinc	207-209	superoxide dismutase 1	Homo sapiens	41-45
25052939-4	2014	The binding of a single Zn(2+) to mutant SOD1 lowered its net charge by an additional +2.33 +- 0.01 to +3.18 +- 0.02 units, however, each protein regulated net charge when binding a second, third, or fourth Zn(2+) (DeltaZ < 0.44 +- 0.07 per additional Zn(2+) ).	Zinc	207-209	superoxide dismutase 1	Homo sapiens	41-45
25105504-8	2014	We found that co-exposure to Zn2+ and Cd2+ synergistically enhanced RNA and protein expression of MT-1, MT-2, and the metal-regulatory transcription factor 1 in MDBK cells.	Zinc	29-33	melatonin receptor 1A	Bos taurus	98-108
24871565-3	2014	A prominent member of IDPs is the peptide amyloid-beta (Abeta) that aggregates into metal-enriched amyloid plaques, a hallmark of Alzheimer"s disease, in which Cu and Zn are bound to Abeta.	Zinc	167-169	amyloid beta precursor protein	Homo sapiens	42-54
24871565-3	2014	A prominent member of IDPs is the peptide amyloid-beta (Abeta) that aggregates into metal-enriched amyloid plaques, a hallmark of Alzheimer"s disease, in which Cu and Zn are bound to Abeta.	Zinc	167-169	amyloid beta precursor protein	Homo sapiens	56-61
24871565-3	2014	A prominent member of IDPs is the peptide amyloid-beta (Abeta) that aggregates into metal-enriched amyloid plaques, a hallmark of Alzheimer"s disease, in which Cu and Zn are bound to Abeta.	Zinc	167-169	amyloid beta precursor protein	Homo sapiens	183-188
24871565-10	2014	For Abeta, this is likely in the neurons that expel Zn or Cu into the synapse and upon metal dysregulation occurring in Alzheimer"s disease.	Zinc	52-54	amyloid beta precursor protein	Homo sapiens	4-9
24871565-12	2014	(iii) Considering the Cu/Zn-Abeta aberrant interaction, therapeutic strategies can be based on removal of Cu/Zn or precluding their binding to the peptide.	Zinc	25-27	amyloid beta precursor protein	Homo sapiens	28-33
24871565-12	2014	(iii) Considering the Cu/Zn-Abeta aberrant interaction, therapeutic strategies can be based on removal of Cu/Zn or precluding their binding to the peptide.	Zinc	109-111	amyloid beta precursor protein	Homo sapiens	28-33
24871565-17	2014	(vi) The Cu/Zn exchange reactions with Abeta are faster than the aggregation process and can hence have a strong impact on this process.	Zinc	12-14	amyloid beta precursor protein	Homo sapiens	39-44
25002230-4	2014	We report herein on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were initially designed so as to interact with the Zn(2+) in p53.	Zinc	145-147	tumor protein p53	Homo sapiens	155-158
24862443-5	2014	Molecular and cellular osteogenic activities demonstrate that rBMSCs cultured on the Zn-implanted coatings have higher ALP activity and up-regulated osteogenic-related genes (OCN, Col-I, ALP, Runx2) compared to the bulk-doped Zn coatings and controls.	Zinc	85-87	RUNX family transcription factor 2	Rattus norvegicus	192-197
24865615-2	2014	Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic Zn(2+) levels.	Zinc	86-88	solute carrier family 30 (zinc transporter), member 8	Mus musculus	21-28
24865615-2	2014	Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic Zn(2+) levels.	Zinc	86-88	solute carrier family 30 (zinc transporter), member 8	Mus musculus	66-84
24865615-10	2014	Implicating lowered ZnT8 levels in the hypoxia-induced fall in cytosolic Zn(2+), genetic ablation of Slc30a8 from mouse islets lowered cytosolic Zn(2+) by ~40% (p &lt; 0.05) and decreased the induction of metallothionein (Mt1, Mt2) genes.	Zinc	73-75	solute carrier family 30 (zinc transporter), member 8	Mus musculus	101-108
24787898-3	2014	The present study seeks to examine the specific role of intramitochondrial Zn(2+) accumulation in ischemic injury, using blockers of the mitochondrial Ca(2+) uniporter (MCU), through which both Zn(2+) and Ca(2+) appear able to enter the mitochondrial matrix.	Zinc	75-81	mitochondrial calcium uniporter	Homo sapiens	169-172
24939841-0	2014	Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome.	Zinc	50-54	gap junction protein beta 2	Homo sapiens	22-26
24939841-4	2014	Plasma pH levels and micromolar concentrations of Zn(2+) inhibit WT Cx26 hemichannels.	Zinc	50-52	gap junction protein beta 2	Homo sapiens	68-72
24787898-3	2014	The present study seeks to examine the specific role of intramitochondrial Zn(2+) accumulation in ischemic injury, using blockers of the mitochondrial Ca(2+) uniporter (MCU), through which both Zn(2+) and Ca(2+) appear able to enter the mitochondrial matrix.	Zinc	194-200	mitochondrial calcium uniporter	Homo sapiens	169-172
24787898-7	2014	These studies suggest that, during acute ischemia, Zn(2+) entry into mitochondria via the MCU induces mitochondrial dysfunction (including ROS generation) that occurs upstream of, and contributes to the terminal Ca(2+) deregulation.	Zinc	51-57	mitochondrial calcium uniporter	Homo sapiens	90-93
24829149-7	2014	Specifically, we found that the inhibition of lysosomal acidification using Bafilomycin A1 (Baf) led to a redistribution of Zn(2+) pools and increased apoptosis.	Zinc	124-126	BAF nuclear assembly factor 1	Homo sapiens	76-79
25100994-4	2014	Recent data suggest that various mutations in SOD-1 affect metal-binding of Cu and Zn, in turn promoting toxic protein aggregation.	Zinc	83-85	superoxide dismutase 1	Homo sapiens	46-51
24264723-9	2014	Nevertheless, application of the CaSR agonist spermine, at concentration below its threshold, enhanced Zn(2+) -dependent Ca(2+) response.	Zinc	103-109	calcium sensing receptor	Homo sapiens	33-37
24619859-3	2014	A decrease in delta-aminolevulinic acid dehydratase (delta-ALA-D) activity in the blood and an increase in urine protein content in renal weight as well as in blood and urine Hg levels were observed in lactating and nonlactating rats from Sal-Hg and Zn-Hg groups.	Zinc	250-252	aminolevulinate dehydratase	Rattus norvegicus	53-64
24619859-3	2014	A decrease in delta-aminolevulinic acid dehydratase (delta-ALA-D) activity in the blood and an increase in urine protein content in renal weight as well as in blood and urine Hg levels were observed in lactating and nonlactating rats from Sal-Hg and Zn-Hg groups.	Zinc	250-252	aminolevulinate dehydratase	Rattus norvegicus	14-51
24692094-1	2014	The dimeric Cu-Zn superoxide dismutase (SOD1) is a particularly interesting system for biological inorganic chemical studies because substitutions of the native Cu and/or Zn ions by a nonnative metal ion cause minimal structural changes and result in high enzymatic activity for those derivatives with Cu remaining in the Cu site.	Zinc	15-17	superoxide dismutase 1	Homo sapiens	40-44
24705244-0	2014	Direct thermodynamic and kinetic measurements of Fe2+ and Zn2+ binding to human serum transferrin.	Zinc	58-62	transferrin	Homo sapiens	86-97
24889871-3	2014	The most common form of the Zn-insulin complex is a hexamer containing two zinc ions.	Zinc	28-30	insulin	Homo sapiens	31-38
24889871-5	2014	We have determined that the dissociation constant value of the monomeric 1 : 1 Zn-insulin complex is equal to 0.40 muM.	Zinc	79-81	insulin	Homo sapiens	82-89
24889871-9	2014	The analysis demonstrates that insulin cannot form complexes with zinc ions in circulation due to the low concentration of free Zn(2+) in this environment.	Zinc	128-134	insulin	Homo sapiens	31-38
24893204-6	2014	Potentiometric titrations of apo-WT1-4 followed by NMR spectroscopy provided the intrinsic pKa values of the Cys2His2 residues, and corresponding potentiometric titrations of Zn(II)-WT1-4 followed by fluorescence spectroscopy yielded the effective pKa(eff) values of the Cys2His2 ligands bound to Zn(II).	Zinc	175-177	WT1 transcription factor	Homo sapiens	33-38
24893204-6	2014	Potentiometric titrations of apo-WT1-4 followed by NMR spectroscopy provided the intrinsic pKa values of the Cys2His2 residues, and corresponding potentiometric titrations of Zn(II)-WT1-4 followed by fluorescence spectroscopy yielded the effective pKa(eff) values of the Cys2His2 ligands bound to Zn(II).	Zinc	175-177	WT1 transcription factor	Homo sapiens	182-187
24893204-7	2014	The Kd, pKa, and pKa(eff) values were combined in a minimal, complete equilibrium model to yield the pH-independent formation constant value for Zn(II)-WT1-4, Kf(ML) value of 7.5 x 10(12) M(-1), with a limiting Kd value of 133 fM.	Zinc	145-147	WT1 transcription factor	Homo sapiens	152-157
24893204-8	2014	This shows that Zn(II) binding to the Cys2His2 site in WT1-4 provides at least -17.6 kcal/mol in driving force to fold the protein scaffold.	Zinc	16-22	WT1 transcription factor	Homo sapiens	55-60
24893204-9	2014	A comparison of the conditional dissociation constants of Zn(II)-WT1-4 to those from the model peptide Zn(II)-GGG-Cys2His2 over the pH range 5.0 to 9.0 and a comparison of their pH-independent Kf(ML) values demonstrates that the free energy cost of protein folding in WT1-4 is less than +2.1 kcal/mol.	Zinc	58-64	WT1 transcription factor	Homo sapiens	65-70
24657933-1	2014	Binding studies of a mononuclear zinc(II) complex, [Zn(dppt)2Cl2] (dppt is 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine), with DNA and bovine serum albumin (BSA) have been investigated under physiological conditions.	Zinc	33-41	albumin	Homo sapiens	139-152
24737106-0	2014	Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn(2+) and Mg (2+).	Zinc	99-101	alkaline phosphatase, placental	Homo sapiens	60-80
24737106-6	2014	The cofactor Zn(2+) also increased ALP activity (an effect that reached a plateau at 2 mM), and co-incubation of 2 mM Zn(2+) with 0.05-0.5 mM SR showed an additive effect on ALP activity stimulation.	Zinc	13-15	alkaline phosphatase, placental	Homo sapiens	35-38
24737106-6	2014	The cofactor Zn(2+) also increased ALP activity (an effect that reached a plateau at 2 mM), and co-incubation of 2 mM Zn(2+) with 0.05-0.5 mM SR showed an additive effect on ALP activity stimulation.	Zinc	13-15	alkaline phosphatase, placental	Homo sapiens	174-177
24737106-6	2014	The cofactor Zn(2+) also increased ALP activity (an effect that reached a plateau at 2 mM), and co-incubation of 2 mM Zn(2+) with 0.05-0.5 mM SR showed an additive effect on ALP activity stimulation.	Zinc	118-120	alkaline phosphatase, placental	Homo sapiens	174-177
24264723-7	2014	Silencing of the CaSR using siRNA or a dominant negative construct reduces the Zn(2+) -dependent signaling.	Zinc	79-85	calcium sensing receptor	Homo sapiens	17-21
24733507-4	2014	Experiments done using the fluorescent probe FluoZin-3 showed that HEK cells possess an intracellular pool of mobilisable Zn present in compartments sensitive to the vesicular proton pump inhibitor Baf-A, which affects endo/lysosomes.	Zinc	122-124	BAF nuclear assembly factor 1	Homo sapiens	198-201
24733507-5	2014	TRPC6 over-expression facilitates the basal uptake of Zn and enhances the size of the pool of Zn sensitive to Baf-A.	Zinc	94-96	BAF nuclear assembly factor 1	Homo sapiens	110-113
24759986-2	2014	The aim of the present study was to investigate a potential involvement of Zn(2+) in the PI3K/Akt pathway of interleukin (IL)-2 signaling in T-cells.	Zinc	75-77	AKT serine/threonine kinase 1	Homo sapiens	94-97
24759986-4	2014	We have previously shown that an IL-2-mediated release of lysosomal Zn(2+) into the cytoplasm activates ERK1/2, but not STAT5.	Zinc	68-70	interleukin 2	Homo sapiens	33-37
24759986-4	2014	We have previously shown that an IL-2-mediated release of lysosomal Zn(2+) into the cytoplasm activates ERK1/2, but not STAT5.	Zinc	68-70	mitogen-activated protein kinase 3	Homo sapiens	104-110
24759986-5	2014	In the present study, Akt phosphorylation in response to IL-2 was abrogated by the Zn(2+) chelator N,N,N",N"-tetrakis-2(pyridyl-methyl)ethylenediamine, and was induced by treatment with Zn(2+) and the ionophore pyrithione.	Zinc	83-85	AKT serine/threonine kinase 1	Homo sapiens	22-25
24759986-5	2014	In the present study, Akt phosphorylation in response to IL-2 was abrogated by the Zn(2+) chelator N,N,N",N"-tetrakis-2(pyridyl-methyl)ethylenediamine, and was induced by treatment with Zn(2+) and the ionophore pyrithione.	Zinc	83-85	interleukin 2	Homo sapiens	57-61
24759986-5	2014	In the present study, Akt phosphorylation in response to IL-2 was abrogated by the Zn(2+) chelator N,N,N",N"-tetrakis-2(pyridyl-methyl)ethylenediamine, and was induced by treatment with Zn(2+) and the ionophore pyrithione.	Zinc	186-188	AKT serine/threonine kinase 1	Homo sapiens	22-25
24759986-5	2014	In the present study, Akt phosphorylation in response to IL-2 was abrogated by the Zn(2+) chelator N,N,N",N"-tetrakis-2(pyridyl-methyl)ethylenediamine, and was induced by treatment with Zn(2+) and the ionophore pyrithione.	Zinc	186-188	interleukin 2	Homo sapiens	57-61
24967969-4	2014	Silencing of ZnR/GPR39 expression attenuated Zn(2+)-dependent activation of ERK1/2 and AKT as well as downstream activation of mTOR/p70S6K, pathways that are linked with proliferation.	Zinc	45-51	thymoma viral proto-oncogene 1	Mus musculus	87-90
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Zinc	21-23	occludin	Mus musculus	167-175
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Zinc	21-23	tight junction protein 1	Mus musculus	177-192
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Zinc	21-23	cadherin 1	Mus musculus	197-207
24698848-6	2014	Treating the EDTA-inactivated catabody with Zn(2+) or Co(2+) restored the Abeta hydrolytic activity, and Zn(2+)-induced catabody conformational transitions were evident by fluorescence emission spectroscopy.	Zinc	44-46	amyloid beta precursor protein	Homo sapiens	74-79
24811232-1	2014	The insulin hexamer is resistant to degradation and fibrillation, which makes it an important quaternary structure for its in vivo storage in Zn(2+)- and Ca(2+)-rich vesicles in the pancreas and for pharmaceutical formulations.	Zinc	142-148	insulin	Homo sapiens	4-11
24794191-1	2014	Sorption of Zn with struvite was assessed both during and after mineral formation at pH 9.0 for 1-100 muM (0.065-6.54 mg L(-1)) aqueous Zn.	Zinc	12-14	latexin	Homo sapiens	102-105
24794191-3	2014	X-ray absorption fine structure spectroscopy confirmed that Zn added to struvite-bearing solutions at concentrations&lt;=5 muM sorbed as both octahedral and tetrahedral complexes (Zn-O 1.98-2.03 A), with evidence for bidentate configuration (Zn-P 3.18 A).	Zinc	60-62	latexin	Homo sapiens	123-126
24326305-3	2014	We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-beta (Abeta) over Zn(II)-Abeta.	Zinc	145-147	amyloid beta precursor protein	Homo sapiens	152-157
24940175-0	2014	BRCAA1 antibody- and Her2 antibody-conjugated amphiphilic polymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer.	Zinc	82-85	AT-rich interaction domain 4B	Homo sapiens	0-6
24874727-4	2014	We have previously reported that Zn(II) restores a folded conformation from mutp53 misfolding, rescuing wild-type (wt) p53/DNA-binding and transcription activities.	Zinc	33-39	tumor protein p53	Homo sapiens	79-82
24874727-9	2014	Mechanistically, Zn(II) restored the wtp53 ability to induce the expression of the p53 target gene DRAM (damage-regulated autophagy modulator), a key regulator of autophagy, leading to autophagic induction.	Zinc	17-23	tumor protein p53	Homo sapiens	39-42
24874727-9	2014	Mechanistically, Zn(II) restored the wtp53 ability to induce the expression of the p53 target gene DRAM (damage-regulated autophagy modulator), a key regulator of autophagy, leading to autophagic induction.	Zinc	17-23	DNA damage regulated autophagy modulator 1	Homo sapiens	99-103
24874727-9	2014	Mechanistically, Zn(II) restored the wtp53 ability to induce the expression of the p53 target gene DRAM (damage-regulated autophagy modulator), a key regulator of autophagy, leading to autophagic induction.	Zinc	17-23	DNA damage regulated autophagy modulator 1	Homo sapiens	105-141
24707508-0	2014	A label-free fluorescence assay for thrombin based on aptamer exonuclease protection and exonuclease III-assisted recycling amplification-responsive cascade zinc(II)-protoporphyrin IX/G-quadruplex supramolecular fluorescent labels.	Zinc	157-165	coagulation factor II, thrombin	Homo sapiens	36-44
24940175-0	2014	BRCAA1 antibody- and Her2 antibody-conjugated amphiphilic polymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer.	Zinc	82-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
24597671-3	2014	This study was to define whether Zn statues (deficiency or supplement) affect the Nrf2 expression and function, and also affect the damage severity of human renal tubular (HK11) cells exposed to high glucose (HG) with palmitate (Pal) and kidney of diabetic mice induced by multiple low-dose streptozotocins.	Zinc	33-35	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
24632388-5	2014	The Zn-implanted titanium can significantly stimulate proliferation of osteoblastic MC3T3-E1 cells as well as initial adhesion, spreading activity, ALP activity, collagen secretion and extracellular matrix mineralization of the rat mesenchymal stem cells.	Zinc	4-6	alopecia, recessive	Mus musculus	148-151
24591003-4	2014	The authors discovered that Zn supplementation inhibited high glucose (HG)-induced NRK-52E cell apoptosis by attenuating reactive oxygen species production, inhibiting HG-induced caspase-3 and caspase-9 activation, and inhibiting the release of cytochrome c from mitochondria to the cytosol.	Zinc	28-30	caspase 9	Rattus norvegicus	193-202
24591003-5	2014	Further analysis revealed that Zn supplementation facilitated cell survival through increasing nuclear translocation of NF-E2-related factor 2 (Nrf2), leading to increased regulation of levels of two antioxidant enzymes, hemeoxygenase-1 and glutamate cysteine ligase, which provided an adaptive survival response against the HG-induced oxidative cytotoxicity.	Zinc	31-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-142
24591003-5	2014	Further analysis revealed that Zn supplementation facilitated cell survival through increasing nuclear translocation of NF-E2-related factor 2 (Nrf2), leading to increased regulation of levels of two antioxidant enzymes, hemeoxygenase-1 and glutamate cysteine ligase, which provided an adaptive survival response against the HG-induced oxidative cytotoxicity.	Zinc	31-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
24591003-6	2014	Moreover, the Zn-mediated increases in Nrf2 activity were suppressed by the pharmacological inhibition of Akt or extracellular signal-regulated kinase 1/2.	Zinc	14-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
24591003-6	2014	Moreover, the Zn-mediated increases in Nrf2 activity were suppressed by the pharmacological inhibition of Akt or extracellular signal-regulated kinase 1/2.	Zinc	14-16	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
24591003-7	2014	Taken together, these findings suggest that Zn antiapoptosis capacity through the activation of Akt and ERK signal pathways leads to Nrf2 activation and, subsequently, Nrf2 target gene induction, thereby protecting the NRK-52E cells from HG-induced apoptosis.	Zinc	44-46	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
24591003-7	2014	Taken together, these findings suggest that Zn antiapoptosis capacity through the activation of Akt and ERK signal pathways leads to Nrf2 activation and, subsequently, Nrf2 target gene induction, thereby protecting the NRK-52E cells from HG-induced apoptosis.	Zinc	44-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	133-137
24591003-7	2014	Taken together, these findings suggest that Zn antiapoptosis capacity through the activation of Akt and ERK signal pathways leads to Nrf2 activation and, subsequently, Nrf2 target gene induction, thereby protecting the NRK-52E cells from HG-induced apoptosis.	Zinc	44-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
24597671-4	2014	For Zn deficiency diabetic mice were treated with Zn chelator PTEN at 5 mg/kg bw daily for 4 months.	Zinc	4-6	phosphatase and tensin homolog	Mus musculus	62-66
24597671-6	2014	Zn supplement prevented the effects of TPEN and also increased Akt and GSK-3beta phosphorylation with a decrease in Nrf2 nuclear exporter, Fyn.	Zinc	0-2	thymoma viral proto-oncogene 1	Mus musculus	63-66
24597671-6	2014	Zn supplement prevented the effects of TPEN and also increased Akt and GSK-3beta phosphorylation with a decrease in Nrf2 nuclear exporter, Fyn.	Zinc	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
24597671-7	2014	All these effects of Zn were abolished by Akt inhibitor.	Zinc	21-23	thymoma viral proto-oncogene 1	Mus musculus	42-45
24597671-8	2014	Therefore, Zn up-regulates Nrf2 function via activating Akt-mediated inhibition of Fyn function.	Zinc	11-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
24597671-8	2014	Therefore, Zn up-regulates Nrf2 function via activating Akt-mediated inhibition of Fyn function.	Zinc	11-13	thymoma viral proto-oncogene 1	Mus musculus	56-59
24597671-10	2014	These results suggest the essentiality of Zn for Nrf2 expression and transcription function.	Zinc	42-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
24287417-1	2014	Electrochemical detection of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) as labeling carriers in an assay for apolipoprotein E (ApoE) detection has been evaluated.	Zinc	65-68	apolipoprotein E	Homo sapiens	126-142
24287417-1	2014	Electrochemical detection of cadmium-selenide/zinc-sulfide (CdSe@ZnS) quantum dots (QDs) as labeling carriers in an assay for apolipoprotein E (ApoE) detection has been evaluated.	Zinc	65-68	apolipoprotein E	Homo sapiens	144-148
24732911-5	2014	Based on systems analysis, we observed that Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.	Zinc	44-46	signal transducer and activator of transcription 3	Mus musculus	117-122
24732911-7	2014	In contrast, Zn inhibited STAT3 activation through the up-regulation of SHP1 activity.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	26-31
24732911-8	2014	Collectively, these findings demonstrate that Zn deficiency enhances the acute phase response through up-regulation of the JAK-STAT3 pathway, thereby perpetuating increased inflammation that may lead to increased morbidity and mortality in response to sepsis.	Zinc	46-48	signal transducer and activator of transcription 3	Mus musculus	127-132
24291623-1	2014	In this work, The effect of three metal ions Zn(2+), Ca(2+) and Na(1+) on the interaction between human serum albumin (HSA) and zonisamide (ZNS) was investigated employing fluorescence, ultraviolet-visible (UV-Vis) absorption and circular dichroism (CD) under simulated physiological conditions.	Zinc	45-47	albumin	Homo sapiens	104-117
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	solute carrier family 30 member 1	Sus scrofa	218-241
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	solute carrier family 30 member 1	Sus scrofa	243-247
24705372-1	2014	The redox properties of cytochrome c (Cyt c), hemoglobin (Hb) and myoglobin (Mb) were studied based on electrostatic interactions between Thioglycolic acid (TGA) capped CdSe/ZnS quantum dots (QDs) and proteins.	Zinc	174-177	cytochrome c, somatic	Homo sapiens	24-36
24675597-2	2014	The large hexagonal unit cell of the delta1p phase with the space group of P63/mmc comprises more or less regular (normal) Zn12 icosahedra, disordered Zn12 icosahedra, Zn16 icosioctahedra and dangling Zn atoms that do not constitute any polyhedra.	Zinc	123-125	delta like non-canonical Notch ligand 1	Homo sapiens	37-44
24703699-5	2014	Moreover, Zn(2+), which is found in insulin formulations at nanomolar concentrations, inhibited POMC neurons via activation of KATP channels.	Zinc	10-12	insulin	Homo sapiens	36-43
24703699-5	2014	Moreover, Zn(2+), which is found in insulin formulations at nanomolar concentrations, inhibited POMC neurons via activation of KATP channels.	Zinc	10-12	proopiomelanocortin	Homo sapiens	96-100
25007625-1	2014	The interaction between CdSe/ZnS(quantum dots)/TiO2 nanocomposites and human serum albumin(HSA) was investigated by resonance light scattering (RLS) spectroscopic methods under approximate physiological conditions.	Zinc	29-32	albumin	Homo sapiens	77-95
25007625-2	2014	Much important information of the interaction between CdSe/ZnS(Quantum Dots)/TiO2 nanocomposites and HSA was obtained by studying comprehensively the Exogenous influence factors of nanocomposites concentration, pH, NaCl concentration, reaction temperature, detection time, coexisting ions, surfactants, sequence of adding to the sample etc.	Zinc	59-62	albumin	Homo sapiens	101-104
24719342-0	2014	The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme.	Zinc	27-35	islet amyloid polypeptide	Mus musculus	75-79
24719342-0	2014	The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme.	Zinc	27-35	insulin degrading enzyme	Mus musculus	83-107
24512348-5	2014	The dominant loss of an amino acid with 1,5-DAN from zn* can be used in pseudo-MS(3) mode to identify the C-terminal side fragments from a complex MALDI-ISD spectrum or to determine missed cleavage residues using MALDI-ISD.	Zinc	53-55	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
26274092-5	2014	The homoleptic zinc(II) complexes had significantly lower reorganization energies than either the free ligands or the BF2(+) chelates.	Zinc	15-23	forkhead box G1	Homo sapiens	118-121
24591629-2	2014	We present the previously unidentified crystal structure of Aft2 bound to DNA that reveals the mechanism of DNA recognition via specific interactions of the iron-responsive element with a Zn(2+)-containing WRKY-GCM1 domain in Aft2.	Zinc	188-194	Aft2p	Saccharomyces cerevisiae S288C	60-64
24591629-2	2014	We present the previously unidentified crystal structure of Aft2 bound to DNA that reveals the mechanism of DNA recognition via specific interactions of the iron-responsive element with a Zn(2+)-containing WRKY-GCM1 domain in Aft2.	Zinc	188-194	Aft2p	Saccharomyces cerevisiae S288C	226-230
24565835-8	2014	The present results demonstrated that Zn supplementation protected against CP-induced testicular damages by modulating metallothionein (MT), tesmin and Nrf2 associated pathways.	Zinc	38-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-156
24528370-1	2014	We report single-crystal X-band EPR and magnetic measurements of the coordination polymer catena-(trans-(mu2-fumarato)tetraaquacobalt(II)), 1, and the Co(II)-doped Zn(II) analogue, 2, in different Zn:Co ratios.	Zinc	164-170	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
24506168-1	2014	The thermodynamics of formation of the insulin hexamer, which is stabilized by two Zn(2+) ions, were quantified by isothermal titration calorimetry (ITC).	Zinc	83-85	insulin	Homo sapiens	39-46
24506168-2	2014	Because the insulin monomer is unstable to aggregation (fibrillation) during ITC measurements, an original method involving EDTA chelation of Zn(2+) from the hexamer was employed.	Zinc	142-144	insulin	Homo sapiens	12-19
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Zinc	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
24590498-8	2014	As Ni(II) and Co(II) ions especially favor octahedral coordination geometry in oxygen-ligand fields, Ni(II) ions and Co(II) ions could only selectively exchange with the octahedral Zn(II) ions, as was also confirmed by the experimental results.	Zinc	181-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
24528370-1	2014	We report single-crystal X-band EPR and magnetic measurements of the coordination polymer catena-(trans-(mu2-fumarato)tetraaquacobalt(II)), 1, and the Co(II)-doped Zn(II) analogue, 2, in different Zn:Co ratios.	Zinc	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
24433538-2	2014	ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter.	Zinc	50-52	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	125-129
23979673-2	2014	In the mammalian pancreas, Zn2+ is essential for the correct processing, storage, secretion, and action of insulin in beta (beta)-cells.	Zinc	27-31	insulin	Homo sapiens	107-114
23979673-3	2014	Insulin is stored inside secretory vesicles or granules, where two Zn2+ ions coordinate six insulin monomers to form the hexameric-structure on which maturated insulin crystals are based.	Zinc	67-71	insulin	Homo sapiens	0-7
23979673-3	2014	Insulin is stored inside secretory vesicles or granules, where two Zn2+ ions coordinate six insulin monomers to form the hexameric-structure on which maturated insulin crystals are based.	Zinc	67-71	insulin	Homo sapiens	92-99
23979673-3	2014	Insulin is stored inside secretory vesicles or granules, where two Zn2+ ions coordinate six insulin monomers to form the hexameric-structure on which maturated insulin crystals are based.	Zinc	67-71	insulin	Homo sapiens	160-167
23979673-6	2014	Hence, the relationship between co-stored Zn2+ and insulin undoubtedly is critical to normal beta-cell function.	Zinc	42-46	insulin	Homo sapiens	51-58
23979673-8	2014	When exocytosis of insulin occurs, insulin granules fuse with the beta-cell plasma membrane and release their contents, i.e., insulin as well as substantial amount of free Zn2+, into the extracellular space and the local circulation.	Zinc	172-176	insulin	Homo sapiens	19-26
23979673-8	2014	When exocytosis of insulin occurs, insulin granules fuse with the beta-cell plasma membrane and release their contents, i.e., insulin as well as substantial amount of free Zn2+, into the extracellular space and the local circulation.	Zinc	172-176	insulin	Homo sapiens	35-42
23979673-8	2014	When exocytosis of insulin occurs, insulin granules fuse with the beta-cell plasma membrane and release their contents, i.e., insulin as well as substantial amount of free Zn2+, into the extracellular space and the local circulation.	Zinc	172-176	insulin	Homo sapiens	35-42
24532689-2	2014	Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain.	Zinc	34-40	RAD50 double strand break repair protein	Mus musculus	0-5
24532689-2	2014	Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain.	Zinc	34-40	RAD50 double strand break repair protein	Mus musculus	83-88
24532689-5	2014	One of these alleles, Rad50(46), conferred reduced Zn(2+) affinity and dimerization efficiency.	Zinc	51-53	RAD50 double strand break repair protein	Mus musculus	22-27
24420568-6	2014	Zn deprivation had a very limited effect on transcript levels of Pi-starvation-responsive genes such as AT4, IPS1, and microRNA399, or on of members of the high-affinity Pi transporter family PHT1.	Zinc	0-2	expressed in response to phosphate starvation protein	Arabidopsis thaliana	104-107
24433538-2	2014	ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter.	Zinc	104-106	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	125-129
24872627-8	2014	CONCLUSION: Patients with DM and periodontitis had altered metabolism of Zn and Mg which were linked to increased values of serum cholesterol and LDL-c and decreased HDL-c, contributing to the progression and complications of type 2 DM with periodontitis.	Zinc	73-75	component of oligomeric golgi complex 2	Homo sapiens	146-151
24433538-3	2014	From this screen two members of the E2F family of transcription factors were found to activate ZRT1 expression in a Zn independent manner.	Zinc	116-118	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	95-99
24587242-6	2014	Moreover, the activity of intracellular Zn(2+) uptake significantly increased in high glucose-treated cells in comparison to 5.5 mM glucose, and the mRNA expression of zinc transporters, ZIP6 and ZIP10, was upregulated in 25 mM glucose-treated cells.	Zinc	40-46	solute carrier family 39 member 6	Homo sapiens	187-191
24586729-2	2014	By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placental isozyme (PLAP) we generated a chimeric enzyme (ChimAP) that retains the structural folding of IAP, but displays greatly increased stability, active site Zn2+ binding, increased transphosphorylation, a higher turnover number and narrower substrate specificity, with comparable selectivity for bacterial lipopolysaccharide (LPS), than the parent IAP isozyme.	Zinc	275-279	alkaline phosphatase, intestinal	Homo sapiens	51-82
24586729-2	2014	By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placental isozyme (PLAP) we generated a chimeric enzyme (ChimAP) that retains the structural folding of IAP, but displays greatly increased stability, active site Zn2+ binding, increased transphosphorylation, a higher turnover number and narrower substrate specificity, with comparable selectivity for bacterial lipopolysaccharide (LPS), than the parent IAP isozyme.	Zinc	275-279	alkaline phosphatase, placental	Homo sapiens	131-135
24463465-3	2014	Here we report the 2.0-A crystal structures of Zn(2+)-free and Zn(2+)-bound Saccharomyces cerevisiae Rpn11 in an MPN-domain heterodimer with Rpn8.	Zinc	47-53	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	101-106
24463465-3	2014	Here we report the 2.0-A crystal structures of Zn(2+)-free and Zn(2+)-bound Saccharomyces cerevisiae Rpn11 in an MPN-domain heterodimer with Rpn8.	Zinc	47-53	proteasome regulatory particle lid subunit RPN8	Saccharomyces cerevisiae S288C	141-145
24463465-3	2014	Here we report the 2.0-A crystal structures of Zn(2+)-free and Zn(2+)-bound Saccharomyces cerevisiae Rpn11 in an MPN-domain heterodimer with Rpn8.	Zinc	63-69	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	101-106
24463465-3	2014	Here we report the 2.0-A crystal structures of Zn(2+)-free and Zn(2+)-bound Saccharomyces cerevisiae Rpn11 in an MPN-domain heterodimer with Rpn8.	Zinc	63-69	proteasome regulatory particle lid subunit RPN8	Saccharomyces cerevisiae S288C	141-145
24587242-7	2014	The deficiency of ZIP6 or ZIP10 and intracellular Zn(2+) significantly inhibited the high migration activity in 25 mM glucose medium, indicating that Zn(2+) transported via ZIP6 and ZIP10 play an essential role in the promotion of cell motility by high glucose stimulation.	Zinc	150-152	solute carrier family 39 member 6	Homo sapiens	18-22
24401367-3	2014	For example Zn, Mg and Mn are cofactors of hundreds of enzymes, and Zn is involved in the synthesis and secretion of insulin from the pancreatic beta-cells.	Zinc	68-70	insulin	Homo sapiens	117-124
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	105-111	sorbitol dehydrogenase	Homo sapiens	134-156
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	105-111	sorbitol dehydrogenase	Homo sapiens	158-162
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	105-107	sorbitol dehydrogenase	Homo sapiens	134-156
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	105-107	sorbitol dehydrogenase	Homo sapiens	158-162
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	232-234	sorbitol dehydrogenase	Homo sapiens	134-156
24111988-5	2014	As validation of our platform, we utilize a peptide-based cysteine-reactive probe to show that the known Zn(2+)-chelating cysteine in sorbitol dehydrogenase (SORD) demonstrates an expected loss in nucleophilicity in the presence of Zn(2+) ions and a gain in nucleophilicity upon treatment with a Zn(2+) chelator.	Zinc	232-234	sorbitol dehydrogenase	Homo sapiens	158-162
24195102-3	2014	In this report, the interaction of amyloid-beta (Abeta) with well-described modulators, (-)epigallocatechin-3-gallate (EGCG) and Zn(ii), was detected using a LED-based interferometric reflectance imaging sensor (LED-IRIS) in a high-throughput and real-time format.	Zinc	129-135	amyloid beta precursor protein	Homo sapiens	49-54
24195102-4	2014	Nucleation-based fibril growth strategy was employed, as the "seeds" of Abeta were prepared in the presence of EGCG and Zn(ii).	Zinc	120-126	amyloid beta precursor protein	Homo sapiens	72-77
24112082-5	2014	In the present study it is shown that exposure of isolated eNOS to HOSCN or MPO/H2O2/SCN(-) decreased active dimeric eNOS levels, and increased inactive monomer and Zn(2+) release, compared with controls, HOCl (hypochlorous acid)- or MPO/H2O2/Cl(-)-treated samples.	Zinc	165-167	myeloperoxidase	Homo sapiens	76-79
24901093-6	2014	After adjustment for age, serum albumin, HDL cholesterol and red blood cell (RBC) were positively and serum insulin and log hsCRP were inversely associated with serum Zn.	Zinc	167-169	insulin	Homo sapiens	108-115
25406481-8	2014	It is suggested that the loss of MSR in mixed systems is the consequence of the very different properties of the binary systems, so that either one of the components (Zn) or a product formed gradually without ignition (e.g. SnSe) can act as an inert component relative to the rest of the system.	Zinc	167-169	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	33-36
24745988-1	2014	The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are involved in the essential maintenance of cellular zinc (Zn2+) and copper (Cu2+) homeostasis, respectively.	Zinc	143-147	calcitonin receptor	Homo sapiens	78-81
24756723-2	2014	In response to the regulatory changes of LEL-specific phosphoinositides or other cellular cues, TRPML1 may mediate the release of Ca(2+) and heavy metal Fe(2+)/Zn(2+)ions into the cytosol from the LEL lumen, which in turn may regulate membrane trafficking events (fission and fusion), signal transduction, and ionic homeostasis in LELs.	Zinc	160-166	mucolipin TRP cation channel 1	Homo sapiens	96-102
24512453-2	2014	By direct measurement of cellular Hg(II) uptake in model iron and sulfate reducing bacteria, we have observed that specific trace metals, such as Zn(II) and Cd(II), inhibit uptake and methylation in these organisms, whereas other metals, such as Ni(II), Co(II), or Fe(II), do not.	Zinc	146-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	254-260
25196974-5	2014	Furthermore, altered expression of rSlc30a5 (knock-down/overexpression) evoked changes in the cytoplasmic Zn(2+) pool indicating its important role in mediating Zn(2+) influx into intracellular compartments of the regulated secretory pathway.	Zinc	106-108	solute carrier family 30 member 5	Rattus norvegicus	35-43
25196974-5	2014	Furthermore, altered expression of rSlc30a5 (knock-down/overexpression) evoked changes in the cytoplasmic Zn(2+) pool indicating its important role in mediating Zn(2+) influx into intracellular compartments of the regulated secretory pathway.	Zinc	161-163	solute carrier family 30 member 5	Rattus norvegicus	35-43
23891797-0	2013	Pyrophosphate-regulated Zn(2+)-dependent DNAzyme activity: an amplified fluorescence sensing strategy for alkaline phosphatase.	Zinc	24-26	alkaline phosphatase, placental	Homo sapiens	106-126
24456271-2	2014	Such a process is linked to the binding of metal ions (e.g., Cu, Fe and Zn) with Abeta.	Zinc	72-74	amyloid beta precursor protein	Homo sapiens	81-86
23573809-3	2014	PEG induced an increase and Zn(2+) a decrease of both ionically bound peroxidase activities.	Zinc	28-30	peroxidase 1	Zea mays	70-80
23573809-5	2014	Isoelectric focusing of ionically bound proteins and activity staining for peroxidase demonstrated increased intensities and appearance of new acidic isoforms, especially in Zn(2+) and PEG treatments.	Zinc	174-176	peroxidase 1	Zea mays	75-85
23891797-1	2013	In this work, based on the fact that pyrophosphate (PPi) could regulate the activity of Zn(2+)-dependent DNAzyme, we for the first time report a fluorescence turn-on sensing system for alkaline phosphatase (ALP) with improved sensitivity via nonprotein-enzymatic signal amplification.	Zinc	88-94	alkaline phosphatase, placental	Homo sapiens	185-205
23891797-1	2013	In this work, based on the fact that pyrophosphate (PPi) could regulate the activity of Zn(2+)-dependent DNAzyme, we for the first time report a fluorescence turn-on sensing system for alkaline phosphatase (ALP) with improved sensitivity via nonprotein-enzymatic signal amplification.	Zinc	88-94	alkaline phosphatase, placental	Homo sapiens	207-210
23891797-4	2013	The introduction of ALP, however, could catalyze the hydrolysis of PPi and release free Zn(2+), resulting in the activation of DNAzyme to catalyze the cleavage of the molecular beacon substrate with a remarkable increase of fluorescent signal.	Zinc	88-90	alkaline phosphatase, placental	Homo sapiens	20-23
23811338-2	2013	Human serum albumin (HSA) is an important physiological transporter of the essential metal ions Cu(2+), and Zn(2+) in the bloodstream.	Zinc	108-110	albumin	Homo sapiens	6-19
24340096-8	2013	Furthermore, block of the mitochondrial Ca(2+) uniporter (MCU), through which Zn(2+) as well as Ca(2+) can enter the mitochondrial matrix, substantially diminished Zn(2+) triggered ROS production, suggesting that the ROS generation occurs specifically in response to Zn(2+) entry into mitochondria.	Zinc	78-80	mitochondrial calcium uniporter	Homo sapiens	58-61
24340096-8	2013	Furthermore, block of the mitochondrial Ca(2+) uniporter (MCU), through which Zn(2+) as well as Ca(2+) can enter the mitochondrial matrix, substantially diminished Zn(2+) triggered ROS production, suggesting that the ROS generation occurs specifically in response to Zn(2+) entry into mitochondria.	Zinc	164-166	mitochondrial calcium uniporter	Homo sapiens	58-61
24340096-8	2013	Furthermore, block of the mitochondrial Ca(2+) uniporter (MCU), through which Zn(2+) as well as Ca(2+) can enter the mitochondrial matrix, substantially diminished Zn(2+) triggered ROS production, suggesting that the ROS generation occurs specifically in response to Zn(2+) entry into mitochondria.	Zinc	164-166	mitochondrial calcium uniporter	Homo sapiens	58-61
24340096-10	2013	Thus, whereas rapid acute accumulation of Zn(2+) and Ca(2+) each can trigger injurious ROS generation, Zn(2+) entry into mitochondria via the MCU may do so with particular potency.	Zinc	103-105	mitochondrial calcium uniporter	Homo sapiens	142-145
23917727-7	2013	The presence of both Zn and Cu in MT1 on Zn supplementation can be related to the role of MT in Zn and Cu homeostasis.	Zinc	21-23	metallothionein 1	Rattus norvegicus	34-37
23917727-7	2013	The presence of both Zn and Cu in MT1 on Zn supplementation can be related to the role of MT in Zn and Cu homeostasis.	Zinc	41-43	metallothionein 1	Rattus norvegicus	34-37
23917727-7	2013	The presence of both Zn and Cu in MT1 on Zn supplementation can be related to the role of MT in Zn and Cu homeostasis.	Zinc	41-43	metallothionein 1	Rattus norvegicus	34-37
23917727-8	2013	Further, the presence of partially metallated MT1 suggests that MT1 may donate fractional amount of metal from it"s fully metallated form to other proteins where Zn acts as a cofactor.	Zinc	162-164	metallothionein 1	Rattus norvegicus	46-49
23917727-8	2013	Further, the presence of partially metallated MT1 suggests that MT1 may donate fractional amount of metal from it"s fully metallated form to other proteins where Zn acts as a cofactor.	Zinc	162-164	metallothionein 1	Rattus norvegicus	64-67
24049181-8	2013	Residues H71 and H116 in Delta2 LHBS, which also contact Zn(2+) ions, are also indispensable for Delta2 LHBS-mediated p27(Kip1) degradation in human HuH7 cells.	Zinc	57-59	zinc ribbon domain containing 2	Homo sapiens	118-121
24037720-2	2013	Systematic investigations on the effects of metal ions such as Cu(2+) and Zn(2+) on the structural and thermodynamic properties of Abeta at the molecular lever seem desirable.	Zinc	74-80	amyloid beta precursor protein	Homo sapiens	131-136
24280450-0	2013	Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis.	Zinc	14-23	tumor protein p53	Homo sapiens	49-52
24280450-9	2013	Our findings indicate that the use of zinc (II) chelators represent a new approach for protecting against radiation-induced p53-dependent apoptosis through the inhibition of p53-dependent apoptotic pathways.	Zinc	38-47	tumor protein p53	Homo sapiens	124-127
24280450-9	2013	Our findings indicate that the use of zinc (II) chelators represent a new approach for protecting against radiation-induced p53-dependent apoptosis through the inhibition of p53-dependent apoptotic pathways.	Zinc	38-47	tumor protein p53	Homo sapiens	174-177
23947440-0	2013	Effects of Zn2+ binding on the structural and dynamic properties of amyloid beta peptide associated with Alzheimer"s disease: Asp1 or Glu11?	Zinc	11-15	amyloid beta precursor protein	Homo sapiens	68-80
23947440-1	2013	Extensive experimental and computational studies have suggested that multiple Zn(2+) binding modes in amyloid beta (Abeta) peptides could exist simultaneously.	Zinc	78-80	amyloid beta precursor protein	Homo sapiens	102-114
23947440-1	2013	Extensive experimental and computational studies have suggested that multiple Zn(2+) binding modes in amyloid beta (Abeta) peptides could exist simultaneously.	Zinc	78-80	amyloid beta precursor protein	Homo sapiens	116-121
24132241-5	2013	Metalloprotein standards for Fe (as ferritin), Cu and Zn (as superoxide dismutase-1) were used to construct multi-point calibration curves for online quantification of metalloproteins by SEC-ICP-MS. Homogenates of primary neuron and astrocyte cultures were analysed by SEC-ICP-MS. Online quantification by external calibration with metalloprotein standards determined the mass of metal eluting from the column relative to time (as pg s(-1)).	Zinc	54-56	superoxide dismutase 1	Homo sapiens	61-83
23954481-3	2013	The fluorescent ion indicators FluoZin-1 and BTC (Invitrogen) were used as competing ligands in titrations involving Zn(II) and Cd(II).	Zinc	117-123	betacellulin	Homo sapiens	31-48
23962156-3	2013	Requiring just a single mutation of the mFruit domain, this new FRET pair improved the dynamic range of protease sensors up to 10-fold and was essential to generate functional red variants of CFP-YFP-based Zn(2+) sensors.	Zinc	206-208	complement factor properdin	Homo sapiens	192-195
24066688-12	2013	Overall, it is the larger size of the Pb(II) center and the availability of coordination positions that enable direct formation of a Pb(II)-OH/Pb(II)-OCH3 mixture versus the initial amide deprotonation identified in the reaction of the Zn(II)-containing 3-ClO4.	Zinc	236-242	submaxillary gland androgen regulated protein 3B	Homo sapiens	143-154
23990470-0	2013	Zn2+ mediates high affinity binding of heparin to the alphaC domain of fibrinogen.	Zinc	0-4	fibrinogen beta chain	Homo sapiens	71-81
23990470-5	2013	Zn(2+) promotes heparin binding to fibrinogen, as determined by chromatography, fluorescence, and surface plasmon resonance.	Zinc	0-6	fibrinogen beta chain	Homo sapiens	35-45
23990470-7	2013	A monoclonal antibody directed against a portion of the fibrinogen alphaC domain removed by plasmin attenuates binding of heparin to fibrinogen and a peptide analog of this region binds heparin in a Zn(2+)-dependent fashion.	Zinc	199-201	fibrinogen beta chain	Homo sapiens	56-66
23990470-8	2013	These results indicate that the alphaC domain of fibrinogen harbors a Zn(2+)-dependent heparin binding site.	Zinc	70-76	fibrinogen beta chain	Homo sapiens	49-59
23990470-9	2013	As a consequence, heparin-catalyzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn(2+) is present.	Zinc	130-132	fibrinogen beta chain	Homo sapiens	94-104
23990470-10	2013	These results reveal the mechanism by which Zn(2+) augments the capacity of fibrinogen to impair the anticoagulant activity of heparin.	Zinc	44-50	fibrinogen beta chain	Homo sapiens	76-86
24020456-6	2013	Experimental results revealed how the subtle differences in the binding affinities between PPi and M in L.M (M is Zn(2+), Cd(2+), and Cu(2+)), could influence the cleavage of the phosphoester linkage in PPi by ALP.	Zinc	114-116	alkaline phosphatase, placental	Homo sapiens	210-213
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	4-7
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	52-54	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	4-7
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23913241-5	2013	For Por-CN, Por-F and Por-Cl, the formation of DyeI(Zn) and DyeI(Zn)-I intermediates are dominant, whereas for Por-H, Por-PhCH3 and Por-OH, the formation of DyeI(Py) and DyeI(Py)-I intermediates predominate.	Zinc	65-67	cytochrome p450 oxidoreductase	Homo sapiens	12-15
23945508-0	2013	Electron transfer from CdSe-ZnS core-shell quantum dots to cobalt(III) complexes.	Zinc	28-31	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	66-69
23945508-1	2013	Fluorescence quenching of CdSe-ZnS quantum dots (core-shell QDs) is shown to be affected in the presence of cobalt(III) complexes with pyridyl anchors.	Zinc	31-34	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	115-118
24033467-10	2013	Zn (II) protoporphyrin IX, a specific inhibitor of HO-1, or siRNA against HO-1 could effectively increase transfer of NF-kappaB.	Zinc	0-2	heme oxygenase 1	Mus musculus	51-55
23816878-4	2013	(65)Zn (t1/2=244.26d; decay mode: EC 98.3%, beta(+) 1.7%) was used as a radiotracer of stable (68)Zn; samples of the purification columns, wastes and product were recovered and measured with a calibrated HPGe gamma-ray spectrometry system.	Zinc	4-6	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	44-53
24033467-10	2013	Zn (II) protoporphyrin IX, a specific inhibitor of HO-1, or siRNA against HO-1 could effectively increase transfer of NF-kappaB.	Zinc	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-127
24051373-2	2013	Zn2+ binds insulin in pancreatic beta cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose.	Zinc	0-4	insulin	Homo sapiens	11-18
24051373-6	2013	propose an additional function for Zn2+ in relation to insulin: regulation of insulin clearance from the bloodstream.	Zinc	35-39	insulin	Homo sapiens	55-62
24051373-6	2013	propose an additional function for Zn2+ in relation to insulin: regulation of insulin clearance from the bloodstream.	Zinc	35-39	insulin	Homo sapiens	78-85
23925449-5	2013	The comprehensive consideration of all the results obtained in this work experimentally demonstrates that the mMT2 isoform exhibits metal ion binding abilities distinct from those of mMT1, with a clear preference for Zn(II) coordination, if compared to Cu(I) or even to Cd(II).	Zinc	217-219	metallothionein 2	Mus musculus	110-114
23925449-4	2013	In the present study, the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (mMT1) isoform, previously determined using the same methodological approach.	Zinc	85-91	metallothionein 2	Mus musculus	59-62
23925449-6	2013	This is in full agreement with the gene expression regulation pattern for the MT1 and MT2 genes, as well as with the hypothesized preferential role of mMT2 in Zn(II) homeostasis mechanisms, while MT1, possibly differentiated from a most recent duplication event in the mammalian MT gene cluster, would have evolved to detoxify Cd(II), and probably other divalent metal ions.	Zinc	159-165	metallothionein 2	Mus musculus	151-155
23925449-4	2013	In the present study, the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (mMT1) isoform, previously determined using the same methodological approach.	Zinc	85-91	metallothionein 2	Mus musculus	64-68
23826687-10	2013	However, we did not detect any changes in bulk metal-binding capacity, overall pectin methylesterification status or cell wall ultrastructure in ozs2, leading us to hypothesize that the ozs2 mutation causes hypersensitivity towards the specific interference of Zn ions with cell wall-controlled growth processes.	Zinc	261-263	pectin methylesterase 3	Arabidopsis thaliana	186-190
24459947-5	2013	However, the results of Gibbs free energy changes still indicats that the coordination of zinc (II) ions is unfavorable for the formation of insulin hexamer, because the standard Gibbs free energy change of the coordinate reaction of zinc (II) ions associated with the formatting insulin hexamer is positive and increased.	Zinc	90-99	insulin	Homo sapiens	141-148
23826687-4	2013	Mutant ozs1 represents a non-functional allele of the vacuolar Zn transporter AtMTP1, providing additional genetic evidence for its major role in Zn(2+) tolerance in seedlings.	Zinc	63-65	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	7-11
23609990-1	2013	Alzheimer"s disease is the most common form of dementia in humans and is related to the accumulation of the amyloid-beta (Abeta) peptide and its interaction with metals (Cu, Fe, and Zn) in the brain.	Zinc	182-184	amyloid beta precursor protein	Homo sapiens	122-127
24057918-7	2013	Immobilized-metal affinity chromatography (IMAC) suggested that VIP1 can bind Zn2+ and Co2+ as well as Ni2+, which is consistent with the known metal-chelating property of polyhistidine.	Zinc	78-82	VIRE2-interacting protein 1	Arabidopsis thaliana	64-68
24459947-5	2013	However, the results of Gibbs free energy changes still indicats that the coordination of zinc (II) ions is unfavorable for the formation of insulin hexamer, because the standard Gibbs free energy change of the coordinate reaction of zinc (II) ions associated with the formatting insulin hexamer is positive and increased.	Zinc	90-99	insulin	Homo sapiens	280-287
24459947-5	2013	However, the results of Gibbs free energy changes still indicats that the coordination of zinc (II) ions is unfavorable for the formation of insulin hexamer, because the standard Gibbs free energy change of the coordinate reaction of zinc (II) ions associated with the formatting insulin hexamer is positive and increased.	Zinc	234-243	insulin	Homo sapiens	141-148
24459947-5	2013	However, the results of Gibbs free energy changes still indicats that the coordination of zinc (II) ions is unfavorable for the formation of insulin hexamer, because the standard Gibbs free energy change of the coordinate reaction of zinc (II) ions associated with the formatting insulin hexamer is positive and increased.	Zinc	234-243	insulin	Homo sapiens	280-287
23965149-2	2013	Metalloprotein anthrax lethal factor (ALF) binds to HNP 1-3 in a Zn2+-dependent manner.	Zinc	65-69	general transcription factor IIA subunit 1 like	Homo sapiens	38-41
23983094-3	2013	This review focuses on biophysical studies of the Abeta peptides: that is, of the aggregation pathways and intermediates observed during aggregation, of the molecular structures observed along these pathways, and of the interactions of Abeta with Cu and Zn ions and with small molecules that modify the aggregation pathways.	Zinc	254-256	amyloid beta precursor protein	Homo sapiens	50-55
23970468-9	2013	A significant positive correlation between the level of Cu/Zn-SOD activity and the levels of Cu (P = 0.003) and Zn (P = 0.005) was found in the cataractous lenses.	Zinc	59-61	superoxide dismutase 1	Homo sapiens	62-65
23902285-7	2013	Study of ER zinc levels in neural stem cells treated with a peroxynitrite generator, Sin-1, revealed an immediate decrease in labile Zn(2+) thus providing evidence for a direct connection between ER stress and ER Zn(2+) homeostasis.	Zinc	133-135	MAPK associated protein 1	Homo sapiens	85-90
23902285-7	2013	Study of ER zinc levels in neural stem cells treated with a peroxynitrite generator, Sin-1, revealed an immediate decrease in labile Zn(2+) thus providing evidence for a direct connection between ER stress and ER Zn(2+) homeostasis.	Zinc	213-215	MAPK associated protein 1	Homo sapiens	85-90
23735664-5	2013	The Zn supplement prevented a decrease in the activity and mRNA of alkaline phosphatase (ALP), osteocalcin mRNA, and hydroxyproline and calcium levels, and an increase in the activity and mRNA of tartrate-resistant acid phosphatase (TRAP) and cathepsin K in the proximal tibia of diabetic rats.	Zinc	4-6	bone gamma-carboxyglutamate protein	Rattus norvegicus	95-106
23787141-1	2013	In order to mimic the active center of matrix metalloproteinases (MMPs), we synthesized a pentadecapeptide (Ac-KAHEFGHSLGLDHSK-NH2) corresponding to the catalytic zinc(II) binding site of human MMP-13.	Zinc	163-171	matrix metallopeptidase 13	Homo sapiens	66-70
23787141-1	2013	In order to mimic the active center of matrix metalloproteinases (MMPs), we synthesized a pentadecapeptide (Ac-KAHEFGHSLGLDHSK-NH2) corresponding to the catalytic zinc(II) binding site of human MMP-13.	Zinc	163-171	matrix metallopeptidase 13	Homo sapiens	194-200
23944230-1	2013	A novel reversible zinc(II) chemosensing ensemble (2 Zn(2+)) allows for selective "turn-on" fluorescence sensing of ATP and PPi in aqueous media (detection limits: 2.4 and 1.0 muM, respectively) giving selective binding patterns: ATP ~ PPi &gt; ADP &gt;&gt; AMP &gt; monophosphates   remaining ions tested.	Zinc	19-27	latexin	Homo sapiens	176-179
23944230-3	2013	Prerequisite Zn(2+) [O(phenol)N(imine)N(pyr)] binding is selective, as determined by UV-vis and NMR spectroscopy; ATP or PPi extracts Zn(2+) to regenerate the ligand-fluorophore conjugate (PPi: turn-on, 512 nm; detection limit, 1.0 muM).	Zinc	13-19	latexin	Homo sapiens	232-235
23944230-3	2013	Prerequisite Zn(2+) [O(phenol)N(imine)N(pyr)] binding is selective, as determined by UV-vis and NMR spectroscopy; ATP or PPi extracts Zn(2+) to regenerate the ligand-fluorophore conjugate (PPi: turn-on, 512 nm; detection limit, 1.0 muM).	Zinc	134-140	latexin	Homo sapiens	232-235
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	AKT serine/threonine kinase 1	Rattus norvegicus	188-191
23939427-4	2013	Both activities strongly depend on Lin28"s RNA-binding domains (RBDs), an N-terminal cold-shock domain (CSD) and a C-terminal Zn-knuckle domain (ZKD).	Zinc	126-128	lin-28 homolog A	Homo sapiens	35-40
23895339-1	2013	Charge recombination rate constants vary no more than 3-fold for interprotein ET in the Zn-substituted wild type (WT) cytochrome c peroxidase (CcP):cytochrome c (Cc) complex and in complexes with four mutants of the Cc protein (i.e., F82S, F82W, F82Y, and F82I), despite large differences in the ET distance.	Zinc	88-90	cytochrome c, somatic	Homo sapiens	118-130
23895339-1	2013	Charge recombination rate constants vary no more than 3-fold for interprotein ET in the Zn-substituted wild type (WT) cytochrome c peroxidase (CcP):cytochrome c (Cc) complex and in complexes with four mutants of the Cc protein (i.e., F82S, F82W, F82Y, and F82I), despite large differences in the ET distance.	Zinc	88-90	cytochrome c, somatic	Homo sapiens	148-160
23712510-0	2013	Aptamer-based turn-on detection of thrombin in biological fluids based on efficient phosphorescence energy transfer from Mn-doped ZnS quantum dots to carbon nanodots.	Zinc	130-133	coagulation factor II, thrombin	Homo sapiens	35-43
23863901-3	2013	This study investigates the role of Zn(2+) on Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF)-dependent signals, the other major intracellular pathway activated by TLR4.	Zinc	36-38	TIR domain containing adaptor molecule 1	Homo sapiens	102-106
23863901-4	2013	Chelation of Zn(2+) with the membrane-permeable chelator N,N,N",N"-Tetrakis(2-pyridylmethyl)ethylenediamine augmented TLR4-mediated production of IFN-beta and subsequent synthesis of inducible NO synthase and production of NO.	Zinc	13-15	nitric oxide synthase 2	Homo sapiens	183-204
23863901-5	2013	The effect is based on Zn(2+) acting as a negative regulator of the TRIF pathway via reducing IFN regulatory factor 3 activation.	Zinc	23-25	TIR domain containing adaptor molecule 1	Homo sapiens	68-72
23863901-8	2013	Taken together, Zn(2+) is specifically involved in TLR signaling, where it differentially regulates MyD88 and TRIF signaling via a zinc signal or via basal Zn(2+) levels, respectively.	Zinc	16-18	TIR domain containing adaptor molecule 1	Homo sapiens	110-114
23863901-8	2013	Taken together, Zn(2+) is specifically involved in TLR signaling, where it differentially regulates MyD88 and TRIF signaling via a zinc signal or via basal Zn(2+) levels, respectively.	Zinc	156-158	TIR domain containing adaptor molecule 1	Homo sapiens	110-114
23726343-2	2013	The functionalized estrogen receptor ligands were prepared by a four-step synthetic strategy, and then three transition metal Pd, Ni, Zn were introduced readily to give the title metal complexes, in which the squaramide was introduced as ion acceptor for the first time in the development of estrogen-derived metal complexes for estrogen receptor.	Zinc	134-136	estrogen receptor 1	Homo sapiens	19-36
23401182-2	2013	A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53.	Zinc	51-53	AKT serine/threonine kinase 1	Homo sapiens	125-128
23401182-2	2013	A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53.	Zinc	51-53	nuclear factor kappa B subunit 1	Homo sapiens	171-193
23401182-2	2013	A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53.	Zinc	51-53	nuclear factor kappa B subunit 1	Homo sapiens	195-205
23401182-2	2013	A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53.	Zinc	51-53	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	208-212
23401182-2	2013	A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53.	Zinc	51-53	tumor protein p53	Homo sapiens	217-220
23401182-4	2013	Intracellular free Zn modulates p53 activity and stability, and excess Zn alters the p53 protein structure and down-regulates p53"s binding to DNA.	Zinc	71-73	tumor protein p53	Homo sapiens	85-88
23401182-4	2013	Intracellular free Zn modulates p53 activity and stability, and excess Zn alters the p53 protein structure and down-regulates p53"s binding to DNA.	Zinc	71-73	tumor protein p53	Homo sapiens	85-88
23401182-6	2013	Cu can also displace Zn from its normal binding site on p53, resulting in abnormal protein folding and disruption of p53 function.	Zinc	21-23	tumor protein p53	Homo sapiens	56-59
23401182-6	2013	Cu can also displace Zn from its normal binding site on p53, resulting in abnormal protein folding and disruption of p53 function.	Zinc	21-23	tumor protein p53	Homo sapiens	117-120
23494165-7	2013	L 1 exhibited high selectivity and sensitivity towards Cu(2+) in both the medium over other common metal ions like Ni(2+), Co(2+), Mn(2+), Mg(2+), Zn(2+), Pb(2+) and Hg(2+).	Zinc	147-149	immunoglobulin kappa variable 1-16	Homo sapiens	0-3
23938376-3	2013	Currently available inhibitors lack specificity for metalloproteinase because of a common Zn binding site in MMPs; thus, there is a need to identify selective MMP-13 inhibitors for osteoarthritis therapy.	Zinc	90-92	matrix metallopeptidase 13	Homo sapiens	109-113
23938376-3	2013	Currently available inhibitors lack specificity for metalloproteinase because of a common Zn binding site in MMPs; thus, there is a need to identify selective MMP-13 inhibitors for osteoarthritis therapy.	Zinc	90-92	matrix metallopeptidase 13	Homo sapiens	159-165
23755195-7	2013	Regarding the inflammation-related processes, the Zn(II) complexes significantly decreased IL-1beta production by a factor of 1.47-2.22 compared with the control (DMSO), but did not affect TNF-alpha and MMP-2 secretions.	Zinc	50-52	interleukin 1 beta	Homo sapiens	91-99
23576296-2	2013	In this work, we report a protein-templated synthesis of Mn-doped ZnS quantum dots (QDs) by exploring bovine serum albumin (BSA) as the template.	Zinc	66-69	albumin	Homo sapiens	109-122
23716681-6	2013	Zn(2+) chelation or loading in cells to alter Zn(2+) availability respectively mimicked or reduced the effects of ZIP12 knockdown on neurite outgrowth.	Zinc	0-2	solute carrier family 39 (zinc transporter), member 12	Mus musculus	114-119
23054276-8	2013	A generalized linear model (GLM) showed that concentrations of Zn and Cu had positive effects on the MT-1 and MT-2 mRNA expression.	Zinc	63-65	metallothionein 1	Rattus norvegicus	101-114
23980892-2	2013	In this mini-review, we briefly examine the basic experimental data on the role of Zn2+ in the retina and photoreceptors, binding of endogenous Zn2+ by zinc-binding sites of differing affinities in rhodopsin, the influence of the exogenous Zn2+ on various properties of rhodopsin, including its ability for phosphorylation and activation of transducin, as well as its thermal stability and regeneration.	Zinc	144-148	rhodopsin	Homo sapiens	198-207
23980892-2	2013	In this mini-review, we briefly examine the basic experimental data on the role of Zn2+ in the retina and photoreceptors, binding of endogenous Zn2+ by zinc-binding sites of differing affinities in rhodopsin, the influence of the exogenous Zn2+ on various properties of rhodopsin, including its ability for phosphorylation and activation of transducin, as well as its thermal stability and regeneration.	Zinc	144-148	rhodopsin	Homo sapiens	198-207
24639783-3	2013	OBJECTIVE: We determined the effect of Zn and low-dose Cd pre-treatment on the expression of Mt1 and Mt2 genes on testicular Sertoli cells.	Zinc	39-41	metallothionein 1	Mus musculus	93-96
24639783-3	2013	OBJECTIVE: We determined the effect of Zn and low-dose Cd pre-treatment on the expression of Mt1 and Mt2 genes on testicular Sertoli cells.	Zinc	39-41	metallothionein 2	Mus musculus	101-104
23652332-0	2013	Selenoprotein P and selenoprotein M block Zn2+ -mediated Abeta42 aggregation and toxicity.	Zinc	42-46	selenoprotein P	Homo sapiens	0-35
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Zinc	185-191	selenoprotein P	Homo sapiens	46-61
23286442-5	2013	The recent association of two "Zn genes", i.e. metallothionein (MT) and Zn transporter 8 (SLC 30A8), with type 2 diabetes at the genetic level and with insulin secretion in clinical studies offers a potential new way to identify new drug targets to modulate Zn homeostasis directly in beta-cells.	Zinc	31-33	solute carrier family 30 member 8	Homo sapiens	90-98
23286442-6	2013	The action of Zn for insulin action in its target organs, as Zn signalling in other pancreatic islet cells, will be addressed.	Zinc	14-16	insulin	Homo sapiens	21-28
23286442-7	2013	Therapeutic Zn-insulin preparations and the influence of Zn and Zn transporters in type 1 diabetes will also be discussed.	Zinc	12-14	insulin	Homo sapiens	15-22
23660814-3	2013	Keeping this view in mind, we performed molecular dynamics simulation of crystal structure complex of testis truncated version of ACE (tACE) and its inhibitor lisinopril along with Zn(2+) to understand the dynamic behavior of active site residues of tACE.	Zinc	181-183	angiotensin I converting enzyme	Homo sapiens	130-133
23660814-7	2013	The residues Asp 7 and Ser 8 of Abeta-peptide were found in close contact with Glu 384 of tACE along with Zn(2+).	Zinc	106-108	amyloid beta precursor protein	Homo sapiens	32-37
23431152-1	2013	Superoxide dismutase-1 (SOD1) is a ubiquitous, Cu and Zn binding, free-radical defense enzyme whose misfolding and aggregation play a potential key role in amyotrophic lateral sclerosis, an invariably fatal neurodegenerative disease.	Zinc	54-56	superoxide dismutase 1	Homo sapiens	0-22
23589615-3	2013	The ALS-causing mutant protein Cu(+)/Zn(+) superoxide dismutase SOD1-G93A directly enhances the activity of the main ROS-producing enzyme in microglia, NADPH oxidase 2 (NOX2), a well-known player in the pathogenesis of ALS.	Zinc	37-39	superoxide dismutase 1, soluble	Mus musculus	64-68
23377617-7	2013	Posttranslationally, the caspase-3-dependent GCLC cleavage was high in Zn-deficient IMR-32 cells.	Zinc	71-73	caspase 3	Homo sapiens	25-34
23501724-1	2013	A novel electrogenerated chemiluminescence (ECL) assay for sensitive determination of thrombin is designed employing CdSe/ZnS quantum dots served as an ECL label.	Zinc	122-125	coagulation factor II, thrombin	Homo sapiens	86-94
23827583-8	2013	Zn release studies (concentrations between 413 muM and 887 muM) evidenced the necessity to tune the cement formulations to reduce the Zn concentration in the surrounding environment.	Zinc	0-2	latexin	Homo sapiens	47-50
23827583-8	2013	Zn release studies (concentrations between 413 muM and 887 muM) evidenced the necessity to tune the cement formulations to reduce the Zn concentration in the surrounding environment.	Zinc	0-2	latexin	Homo sapiens	59-62
23431152-1	2013	Superoxide dismutase-1 (SOD1) is a ubiquitous, Cu and Zn binding, free-radical defense enzyme whose misfolding and aggregation play a potential key role in amyotrophic lateral sclerosis, an invariably fatal neurodegenerative disease.	Zinc	54-56	superoxide dismutase 1	Homo sapiens	24-28
23266931-5	2013	The molecular mechanism responsible for the insulin-like effects of Zn compounds involves the activation of several key components of the insulin signaling pathways, which include the extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3-K)/protein kinase B/Akt (PKB/Akt) pathways.	Zinc	68-70	mitogen-activated protein kinase 1	Homo sapiens	184-225
23281060-0	2013	Zn2+ -induced ERK activation mediates PARP-1-dependent ischemic-reoxygenation damage to oligodendrocytes.	Zinc	0-4	mitogen-activated protein kinase 1	Homo sapiens	14-17
23281060-0	2013	Zn2+ -induced ERK activation mediates PARP-1-dependent ischemic-reoxygenation damage to oligodendrocytes.	Zinc	0-4	poly(ADP-ribose) polymerase 1	Homo sapiens	38-44
23281060-6	2013	ERK1/2 activation was blocked by the high-affinity Zn(2+) chelator TPEN, but not by antagonists of AMPA/kainate or P2X7 receptors that were previously shown to be involved in ischemic oligodendroglial cell death.	Zinc	51-53	mitogen-activated protein kinase 3	Homo sapiens	0-6
23281060-9	2013	Moreover, UO126 blocked the ischemia-induced increase in poly-[ADP]-ribosylation of proteins, and the poly[ADP]-ribose polymerase 1 (PARP-1) inhibitor DPQ significantly inhibited ischemia-induced oligodendroglial cell death-demonstrating that PARP-1 was required downstream in the Zn(2+)-ERK oligodendrocyte cell death pathway.	Zinc	281-285	poly(ADP-ribose) polymerase 1	Homo sapiens	102-131
23281060-9	2013	Moreover, UO126 blocked the ischemia-induced increase in poly-[ADP]-ribosylation of proteins, and the poly[ADP]-ribose polymerase 1 (PARP-1) inhibitor DPQ significantly inhibited ischemia-induced oligodendroglial cell death-demonstrating that PARP-1 was required downstream in the Zn(2+)-ERK oligodendrocyte cell death pathway.	Zinc	281-285	poly(ADP-ribose) polymerase 1	Homo sapiens	133-139
23266931-5	2013	The molecular mechanism responsible for the insulin-like effects of Zn compounds involves the activation of several key components of the insulin signaling pathways, which include the extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3-K)/protein kinase B/Akt (PKB/Akt) pathways.	Zinc	68-70	mitogen-activated protein kinase 3	Homo sapiens	227-233
23266931-5	2013	The molecular mechanism responsible for the insulin-like effects of Zn compounds involves the activation of several key components of the insulin signaling pathways, which include the extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3-K)/protein kinase B/Akt (PKB/Akt) pathways.	Zinc	68-70	AKT serine/threonine kinase 1	Homo sapiens	277-306
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Zinc	157-159	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
23281053-7	2013	Importantly, this analog was capable of forming hexamer upon Zn addition as typical for wild-type insulin and its crystal structure showed only minor deviations from the classical insulin structure.	Zinc	61-63	insulin	Homo sapiens	98-105
22640991-7	2013	The risk of higher levels of TNF-alpha, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0 63, 95% CI 0 42, 0 96, P= 0 03; OR 0 57, 95% CI 0 39, 0 86, P= 0 025; OR 0 63, 95% CI 0 41, 0 96, P= 0 04; OR 0 62, 95% CI 0 41, 0 95, P= 0 03, respectively).	Zinc	112-114	tumor necrosis factor	Homo sapiens	29-38
22640991-7	2013	The risk of higher levels of TNF-alpha, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0 63, 95% CI 0 42, 0 96, P= 0 03; OR 0 57, 95% CI 0 39, 0 86, P= 0 025; OR 0 63, 95% CI 0 41, 0 96, P= 0 04; OR 0 62, 95% CI 0 41, 0 95, P= 0 03, respectively).	Zinc	112-114	interleukin 6	Homo sapiens	40-44
23287963-3	2013	Their presence in mutant Cu(2+)/Zn(2+) superoxide dismutase (mSOD1) induced ALS plays an important role in shifting the response of microglia from neuroprotective to neurotoxic.	Zinc	32-34	superoxide dismutase 1, soluble	Mus musculus	61-66
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Zinc	108-110	amyloid beta precursor protein	Homo sapiens	63-75
23276205-2	2013	Neuronal toxicity in AD has been linked to the interactions of amyloid-beta (Abeta) with metals, especially Zn(2+), Cu(2+), and Fe(3+), which leads to the production of reactive oxygen species.	Zinc	108-110	amyloid beta precursor protein	Homo sapiens	77-82
23151080-7	2013	However, Zn2+, a voltage-independent NR2A-containing NMDA-R antagonist, prevented glycine-induced LTP.	Zinc	9-13	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	37-41
23161089-6	2013	Assay of the stoichiometry of metal binding to the purified rh-HSPA5 showed that one molecule of the rh-HSPA5 could chelate 1 or 2 Cu, 13 iron (Fe), 5 zinc (Zn) and 10 lead (Pb) ions but not manganese (Mn).	Zinc	157-159	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-109
23546293-10	2013	Interestingly, we found that pretreatment with Apo decreased elevation of intracellular Zn(2+) levels after Zn(2+) exposure and induced mRNA expression of the zinc transporter ZnT1, which transports intracellular Zn(2+) out of cells, and metallothionein.	Zinc	88-90	solute carrier family 30 member 1	Homo sapiens	176-180
23195954-4	2013	Zn(2+) binding allosterically and negatively regulates the serine protease activity of calnuc, inhibition being caused by an "open to close" change in its conformation not seen upon Ca(2+) binding.	Zinc	0-6	coagulation factor II, thrombin	Homo sapiens	59-74
23546293-10	2013	Interestingly, we found that pretreatment with Apo decreased elevation of intracellular Zn(2+) levels after Zn(2+) exposure and induced mRNA expression of the zinc transporter ZnT1, which transports intracellular Zn(2+) out of cells, and metallothionein.	Zinc	108-110	solute carrier family 30 member 1	Homo sapiens	176-180
23546293-10	2013	Interestingly, we found that pretreatment with Apo decreased elevation of intracellular Zn(2+) levels after Zn(2+) exposure and induced mRNA expression of the zinc transporter ZnT1, which transports intracellular Zn(2+) out of cells, and metallothionein.	Zinc	108-110	solute carrier family 30 member 1	Homo sapiens	176-180
22803791-0	2013	The substitutions G245C and G245D in the Zn(2+)-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain.	Zinc	41-47	tumor protein p53	Homo sapiens	70-73
24235910-1	2013	Heterobimetallic complexes of Zn(II) and Sn(IV) with sarcosine have been synthesized at room temperature under stirring conditions by the reaction of sarcosine and zinc acetate in 2 : 1 molar ratio followed by the stepwise addition of CS2 and organotin(IV) halides, where R = Me, n-Bu, and Ph.	Zinc	30-32	chorionic somatomammotropin hormone 2	Homo sapiens	235-238
23484196-2	2013	The protein modified by Zn cations 1.2 times more actively (p&lt;0.01) induced early IL-1beta than the control gamma-globulin, while gamma-globulin metal complex with copper was 1.4 times less active (p&lt;0.1) than the control protein.	Zinc	24-26	interleukin 1 beta	Homo sapiens	85-93
24024496-5	2013	In equi-molar mixed-Pb(II)-Zn(II) systems, partitioning of both ions onto alpha-Al2O3(1-102) decreased compared with the single-metal-ion systems; however, Zn(II) decreased Pb(II) sorption to a greater extent than vice versa, suggesting that Zn(II) outcompeted Pb(II) for alpha-Al2O3(1-102) sorption sites.	Zinc	27-32	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
24024496-5	2013	In equi-molar mixed-Pb(II)-Zn(II) systems, partitioning of both ions onto alpha-Al2O3(1-102) decreased compared with the single-metal-ion systems; however, Zn(II) decreased Pb(II) sorption to a greater extent than vice versa, suggesting that Zn(II) outcompeted Pb(II) for alpha-Al2O3(1-102) sorption sites.	Zinc	27-29	submaxillary gland androgen regulated protein 3B	Homo sapiens	20-26
23303748-7	2013	Under optimum conditions, a comparison between monomer-to-dimer abundance ratios of two small sets of blood samples from healthy control and ALS patients demonstrated the presence of a higher relative abundance of Cu,Zn-monomer SOD-1 in patient samples.	Zinc	217-219	superoxide dismutase 1	Homo sapiens	228-233
23063975-4	2013	Moreover, we demonstrate unambiguously that Zn(2+) induced TIM15 folding is essential for its role as mtHsp70 chaperone since in the unstructured apo state TIM15 does not bind to mtHsp70 and is unable to prevent its aggregation.	Zinc	44-46	heat shock protein family A (Hsp70) member 9	Homo sapiens	102-109
24273918-11	2013	A positive correlation was found between serum level of IL-8 and each of GSH (r = -0.534 and p = 0.000), SOD (r = -0.295 and p = 0.021), CAT (r = -0.545 and p = 0.000), and Zn (r = 0.422 and p = 0.001) in all patient groups.	Zinc	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24273928-0	2013	Can cranberry extract and vitamin C + Zn supplements affect the in vivo activity of paraoxonase 1, antioxidant potential, and lipid status?	Zinc	38-40	paraoxonase 1	Homo sapiens	84-97
24273928-5	2013	The aim of this study was to analyze the effects of cranberry extract and vitamin C and zinc preparations (vitamin C + Zn) on serum paraoxonase 1 activity, antioxidant status, and glucose and lipid concentration.	Zinc	119-121	paraoxonase 1	Homo sapiens	132-145
24273928-8	2013	RESULTS: The results have shown that there is a significant increase in the activity of the paraoxonase 1 in nonsmokers after the intervention with the cranberry extract as well as with vitamin C + Zn preparations.	Zinc	198-200	paraoxonase 1	Homo sapiens	92-105
23711853-3	2013	Intracellular Zn levels increase in mouse MCs after FcepsilonRI stimulation.	Zinc	14-16	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	52-63
23711853-16	2013	Knockdown of the Zn efflux transporter, ZnT1, significantly inhibited Zn release from human MCs.	Zinc	17-19	solute carrier family 30 member 1	Homo sapiens	40-44
23289009-8	2013	Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.	Zinc	19-21	CD4 molecule	Homo sapiens	70-73
23289009-8	2013	Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.	Zinc	19-21	CD4 molecule	Homo sapiens	109-112
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-87	tumor protein p53	Homo sapiens	77-80
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-87	tumor protein p53	Homo sapiens	170-173
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-87	tumor protein p53	Homo sapiens	170-173
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-83	tumor protein p53	Homo sapiens	77-80
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-83	tumor protein p53	Homo sapiens	170-173
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	81-83	tumor protein p53	Homo sapiens	170-173
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	140-142	tumor protein p53	Homo sapiens	77-80
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	140-142	tumor protein p53	Homo sapiens	170-173
22803791-3	2013	We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-binding pocket can presumably exert an influence on Zn(2+) position in the Zn(2+)-p53 complex and thereby affect p53 binding to DNA.	Zinc	140-142	tumor protein p53	Homo sapiens	170-173
22803791-4	2013	With these background considerations, our aim was to estimate the effect of the putative changes in the Zn(2+) position in its binding pocket due to the G245C and G245D substitutions on the conformation of the p53 DNA-binding motif.	Zinc	104-106	tumor protein p53	Homo sapiens	210-213
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	66-68	tumor protein p53	Homo sapiens	130-133
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	66-68	tumor protein p53	Homo sapiens	189-192
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	66-68	tumor protein p53	Homo sapiens	189-192
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	209-211	tumor protein p53	Homo sapiens	130-133
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	209-211	tumor protein p53	Homo sapiens	130-133
22803791-6	2013	MD simulations demonstrated that (1) the two substitutions in the Zn(2+)-binding pocket caused changes in the conformation of the p53 DNA-binding motif, as compared with the wild-type (WT) p53; (2) binding of Zn(2+) to the p53 mutant forms reduced the effect of the substitutions on conformational change; and (3) Zn(2+) binding in the normal position compensated the effect of the mutations on the conformation in comparison to the altered Zn(2+) position.	Zinc	209-211	tumor protein p53	Homo sapiens	130-133
23335960-0	2013	G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.	Zinc	79-87	G protein-coupled receptor 83	Mus musculus	0-29
23086867-6	2013	Insulin is stored in dense core vesicles with Zn(2+) ions in pancreatic beta-cells.	Zinc	46-48	insulin	Homo sapiens	0-7
23335960-0	2013	G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.	Zinc	79-87	G protein-coupled receptor 83	Mus musculus	31-36
23335960-7	2013	Furthermore, we found that, under physiological conditions, zinc(II) (but not calcium(II) and magnesium(II)) potently activates mGPR83, thus identifying zinc(II) as an endogenous molecule with agonistic capability to activate mGPR83.	Zinc	60-68	G protein-coupled receptor 83	Mus musculus	128-134
23335960-7	2013	Furthermore, we found that, under physiological conditions, zinc(II) (but not calcium(II) and magnesium(II)) potently activates mGPR83, thus identifying zinc(II) as an endogenous molecule with agonistic capability to activate mGPR83.	Zinc	60-68	G protein-coupled receptor 83	Mus musculus	226-232
23335960-7	2013	Furthermore, we found that, under physiological conditions, zinc(II) (but not calcium(II) and magnesium(II)) potently activates mGPR83, thus identifying zinc(II) as an endogenous molecule with agonistic capability to activate mGPR83.	Zinc	153-161	G protein-coupled receptor 83	Mus musculus	128-134
23335960-7	2013	Furthermore, we found that, under physiological conditions, zinc(II) (but not calcium(II) and magnesium(II)) potently activates mGPR83, thus identifying zinc(II) as an endogenous molecule with agonistic capability to activate mGPR83.	Zinc	153-161	G protein-coupled receptor 83	Mus musculus	226-232
23335960-8	2013	In line with the observation that zinc(II)-ions activate mGPR83, we identified a cluster of ion-binding sensitive amino acids (e.g. His145, His204, Cys207, Glu217) in an activation sensitive receptor region of mGPR83.	Zinc	34-42	G protein-coupled receptor 83	Mus musculus	57-63
23335960-9	2013	The occurrence of a constitutive activating mutant and a zinc(II)-binding residue at the N-terminal part corroborate the importance of this region in mGPR83 signal regulation.	Zinc	57-65	G protein-coupled receptor 83	Mus musculus	150-156
23650973-6	2013	Zn plasma levels were negatively correlated to TNF-alpha (r = -0.49; p = 0.0001) and LDL(-) (r = -0.33; p = 0.008).	Zinc	0-2	tumor necrosis factor	Homo sapiens	47-56
23652223-9	2012	Cadmium has also been shown to replace Zn in the tumor suppressor protein, p53 thereby impairing p53"s DNA binding activity and associated repair processes.	Zinc	39-41	tumor protein p53	Homo sapiens	75-78
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	31-33	solute carrier family 39 member 6	Homo sapiens	160-164
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	137-139	solute carrier family 39 member 6	Homo sapiens	60-64
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	137-139	solute carrier family 39 member 6	Homo sapiens	160-164
23652223-9	2012	Cadmium has also been shown to replace Zn in the tumor suppressor protein, p53 thereby impairing p53"s DNA binding activity and associated repair processes.	Zinc	39-41	tumor protein p53	Homo sapiens	97-100
23007663-1	2012	Reaction of imidazole aldehydes with dihydrazino derivatives of 2-phenylpyrimidine provides a family of bis(acylhydrazone) ligands which form [2 x 2] metallogrid complexes with transition metal ions including Fe(II), Co(II), Cu(II) and Zn(II).	Zinc	236-242	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-223
23047153-2	2012	Moreover, this probe has been applied for Zn(2+) detection in blood serum upto 8.7 muM and fluoride detection upto 22 nM in waste water samples, using emission spectra.	Zinc	42-48	latexin	Homo sapiens	83-86
22983773-1	2012	Zinc (Zn), a cell-protective metal against various toxic compounds, is the key agent for neutral endopeptidase (NEP) functional structure.	Zinc	6-8	membrane metalloendopeptidase	Homo sapiens	89-110
23138109-2	2012	In this paper, CdSe/ZnS QDs probes for targeted delivery to mouse and human cells using aptamer GS24 and peptide T7 specific to mouse/human transferrin receptors were developed.	Zinc	20-23	transferrin	Homo sapiens	140-151
22826039-5	2012	Further analysis revealed that Zn supplementation facilitated cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway and MAPK/ERK pathways.	Zinc	31-33	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
22983773-1	2012	Zinc (Zn), a cell-protective metal against various toxic compounds, is the key agent for neutral endopeptidase (NEP) functional structure.	Zinc	6-8	membrane metalloendopeptidase	Homo sapiens	112-115
23064315-4	2012	The aim of             this study was to determine the expression levels of selected miRNA and zinc(II)-related             genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in             comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II)             treatment.	Zinc	95-103	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
22639383-4	2012	We found that Zn supplementation significantly inhibited TGF-beta1 and ROS production, and attenuated the HG-induced EMT in the RPMCs, likely through inhibition of MAPK, NF-kappaB, and TGF-beta/Smad pathways.	Zinc	14-16	transforming growth factor, beta 1	Rattus norvegicus	57-66
22639383-4	2012	We found that Zn supplementation significantly inhibited TGF-beta1 and ROS production, and attenuated the HG-induced EMT in the RPMCs, likely through inhibition of MAPK, NF-kappaB, and TGF-beta/Smad pathways.	Zinc	14-16	transforming growth factor, beta 1	Rattus norvegicus	57-65
23023303-7	2012	FACS analysis was used to assess the function of PLAG1 in low endogenously             expressing, but Zn-inducible stable PLAG1 expressing JEG-3 cell clones.	Zinc	103-105	PLAG1 zinc finger	Homo sapiens	49-54
23023303-7	2012	FACS analysis was used to assess the function of PLAG1 in low endogenously             expressing, but Zn-inducible stable PLAG1 expressing JEG-3 cell clones.	Zinc	103-105	PLAG1 zinc finger	Homo sapiens	123-128
22832069-0	2012	Structural basis behind the interaction of Zn2+ with the protein alpha-synuclein and the Abeta peptide: a comparative analysis.	Zinc	43-47	amyloid beta precursor protein	Homo sapiens	89-94
22820507-7	2012	The rise in Ca(2+)(i) induced by PIF and AngII was completely attenuated by the Zn(2+) chelator D-myo-inositol-1,2,6-triphosphate, and this was reversed by administration of exogenous Zn(2+).	Zinc	80-82	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	41-46
23062696-8	2012	Our results indicate that metal induced Abeta aggregation strongly affects the metabolites involved in the neurotransmission activity supporting a deleterious impact of Cu(2+) and Zn(2+) Abeta amyloidogenesis on astrocyte functions.	Zinc	180-182	amyloid beta precursor protein	Homo sapiens	40-45
23099538-6	2012	Mn(II) binding to HSA is modulated by Zn(II), pH, and myristate through competitive inhibition and allosteric mechanisms.	Zinc	38-44	albumin	Homo sapiens	18-21
23073212-3	2012	Here we report the binding interaction of a model plasma protein Bovine Serum Albumin (BSA) with a magnetic nanoparticle of mixed spinel origin (Ni(0.5)Zn(0.5)Fe(2)O(4), abbreviated as NZFO from now and onwards).	Zinc	152-154	albumin	Homo sapiens	72-85
22820507-7	2012	The rise in Ca(2+)(i) induced by PIF and AngII was completely attenuated by the Zn(2+) chelator D-myo-inositol-1,2,6-triphosphate, and this was reversed by administration of exogenous Zn(2+).	Zinc	184-186	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	41-46
23018277-2	2012	A computer model for the speciation of the trace elements Fe(3+), Fe(2+), Cu(2+), Zn(2+), and Mn(2+) in phloem sap has been developed.	Zinc	82-84	SH2 domain containing 1A	Homo sapiens	111-114
22696393-8	2012	The results showed that the Sr, Zn, and Si (or Sr, Mg, and Si)-containing ionic products from SZS and SMS powders enhanced ALP activity of BMSCs, compared to those from beta-TCP.	Zinc	32-34	alkaline phosphatase, placental	Homo sapiens	123-126
23030804-3	2012	The relative intensity ratio of monomer to excimer fluorescence (M(376)/E(465)) of the sensor increases 80-fold upon the addition of 10 equiv of Zn(2+) ions (with a detection limit of 0.2 muM).	Zinc	145-147	latexin	Homo sapiens	188-191
22932912-1	2012	Based on 6-hydroxyindole BODIPY with a Schiff-base structure, NIR fluorescence with impressively high selectivity is triggered by deprotonation of the phenol group upon binding with Zn(2+) due to the chelation-enhanced fluorescence effect, thus realizing a promising application in bioimaging of Zn(2+).	Zinc	182-184	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	62-65
22996637-0	2012	Conjugation of transferrin to azide-modified CdSe/ZnS core-shell quantum dots using cyclooctyne click chemistry.	Zinc	50-53	transferrin	Homo sapiens	15-26
22978548-0	2012	By increasing the affinity of heparin for fibrin, Zn(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin.	Zinc	50-56	coagulation factor II, thrombin	Homo sapiens	101-109
22978548-0	2012	By increasing the affinity of heparin for fibrin, Zn(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin.	Zinc	50-56	coagulation factor II, thrombin	Homo sapiens	139-147
22978548-5	2012	In contrast, in the presence of heparin, Zn(2+) increased the affinity of thrombin for gamma(A)/gamma(A)-fibrin 4-fold (from a K(d) value of 0.8 to 0.2 muM) and slowed the rate of thrombin dissociation from gamma(A)/gamma(A)-fibrin clots.	Zinc	41-43	coagulation factor II, thrombin	Homo sapiens	74-82
22978548-5	2012	In contrast, in the presence of heparin, Zn(2+) increased the affinity of thrombin for gamma(A)/gamma(A)-fibrin 4-fold (from a K(d) value of 0.8 to 0.2 muM) and slowed the rate of thrombin dissociation from gamma(A)/gamma(A)-fibrin clots.	Zinc	41-43	coagulation factor II, thrombin	Homo sapiens	180-188
22978548-6	2012	These findings suggest that Zn(2+) enhances the formation of ternary heparin-thrombin-fibrin complexes with gamma(A)/gamma(A)-fibrin but does not influence the already high affinity interaction of thrombin with gamma(A)/gamma"-fibrin.	Zinc	28-34	coagulation factor II, thrombin	Homo sapiens	77-85
22978548-8	2012	Therefore, by enhancing the binding of heparin to fibrin, physiological concentrations of Zn(2+) render fibrin-bound thrombin more protected from inhibition by antithrombin.	Zinc	90-96	coagulation factor II, thrombin	Homo sapiens	117-125
22989181-1	2012	The active site for the family GH38 class II alpha-mannosidase is constituted in part by a divalent metal ion, mostly Zn(2+), as revealed in the crystal structures of enzymes from both animal and bacterial sources.	Zinc	118-120	SDR family oxidoreductase	Saccharolobus solfataricus	45-62
22982309-0	2012	Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a.	Zinc	13-15	metallothionein 1A	Homo sapiens	65-83
22982309-6	2012	Detailed ESI-MS metalation data of human recombinant MT 1a by Zn(2+) and Cd(2+) are also reported.	Zinc	62-64	metallothionein 1A	Homo sapiens	53-58
22932912-0	2012	Target-triggered deprotonation of 6-hydroxyindole-based BODIPY: specially switch on NIR fluorescence upon selectively binding to Zn2+.	Zinc	129-133	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	84-87
22932912-1	2012	Based on 6-hydroxyindole BODIPY with a Schiff-base structure, NIR fluorescence with impressively high selectivity is triggered by deprotonation of the phenol group upon binding with Zn(2+) due to the chelation-enhanced fluorescence effect, thus realizing a promising application in bioimaging of Zn(2+).	Zinc	296-298	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	62-65
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	153-159	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	209-216
22932316-5	2012	The structural similarity between the potent HDAC inhibitor trichostatin A (TSA, 1; HDAC1, IC(50) 12nM) and the present compounds (2-7) was high at the Zn(II) coordinating hydroxamic acid head group; and in selected compounds (2, 5), at the 4-(dimethylamino)phenyl tail.	Zinc	152-154	lymphocyte antigen 6 family member E	Homo sapiens	60-82
22932316-5	2012	The structural similarity between the potent HDAC inhibitor trichostatin A (TSA, 1; HDAC1, IC(50) 12nM) and the present compounds (2-7) was high at the Zn(II) coordinating hydroxamic acid head group; and in selected compounds (2, 5), at the 4-(dimethylamino)phenyl tail.	Zinc	152-154	histone deacetylase 1	Homo sapiens	84-89
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	153-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	63-65	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	209-216
22985442-7	2012	In the formation of 2-6, two Tab ligands are removed from the [Zn(Tab)(4)](2+) dication when it is attacked by L ligands, while in the cases of 7-9, the Zn(II) of the [Zn(Tab)(4)](2+) dication was replaced by Co(III) (derived from oxidation of Co(II) by O(2)) followed by the removal of two Tab ligands via L ligands.	Zinc	63-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	209-214
22985442-8	2012	In the case of 10, the central Zn(II) of the [Zn(Tab)(4)](2+) dication was displaced by Co(II) followed by the removal of three Tab ligands via one Cl(-) and one tridentate bdmppy.	Zinc	31-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-94
22766626-6	2012	We found that zinc(II) ions caused elevated expression             of Ki-67, a marker of proliferation, extremely low expression of p53, high expression             of Bcl-2 and no changes in the expression of p53.	Zinc	14-22	tumor protein p53	Homo sapiens	132-135
22556098-5	2012	In 2-parameter models, Mg, Ca, or pH are selected by stepwise multiple regression for Ni, Cu, and Zn HC5, respectively, and increase the accuracy to 87%-94%.	Zinc	98-100	CYCS pseudogene 1	Homo sapiens	101-104
22556098-7	2012	Three-parameter models have DOC and pH in common, the third parameter is Mg, Ca, or Na for HC5 of Ni, Cu, and Zn, respectively.	Zinc	110-112	CYCS pseudogene 1	Homo sapiens	91-94
23372928-2	2012	Intracellular zinc ([Zn](i)) is maintained across a wide range of cells and species in a tight quota (100 to 500 muM) by a dynamic process of transport, intracellular vesicular storage, and binding to a large number of proteins (estimated at 3-10% of human proteome).	Zinc	21-23	latexin	Homo sapiens	113-116
22913772-0	2012	Reactive cysteine in the structural Zn(2+) site of the C1B domain from PKCalpha.	Zinc	36-42	protein kinase C alpha	Homo sapiens	71-79
22913772-7	2012	Our data suggest that Cys151 serves as an entry point for the reactive oxygen species that activate PKCalpha in a process involving Zn(2+) release.	Zinc	132-134	protein kinase C alpha	Homo sapiens	100-108
22879413-8	2012	SPR data demonstrated the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulfate, and corneal basement membrane molecules, laminin and heparan sulfate--only in the presence of Zn(2+).	Zinc	221-223	fibrinogen beta chain	Homo sapiens	37-40
22957890-1	2012	Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM).	Zinc	91-97	C-C motif chemokine receptor 8	Homo sapiens	58-62
22957890-1	2012	Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM).	Zinc	91-97	latexin	Homo sapiens	210-213
22957890-4	2012	A screening of 20 chelator analogues in complex with Zn(II) identified compounds with increased potencies, with 7 reaching highest potency at CCR1 (EC(50) of 0.85 muM), 20 at CCR8 (0.39 muM), and 8 at CCR5 (1.0 muM).	Zinc	53-55	C-C motif chemokine receptor 8	Homo sapiens	175-179
22843691-6	2012	The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8.	Zinc	99-101	interleukin 6	Homo sapiens	131-144
22843691-6	2012	The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8.	Zinc	99-101	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
22801428-2	2012	The BBX32 protein is a member of the B-box zinc finger family from A. thaliana and contains a single conserved Zn(2+)-binding B-box domain at the N terminus.	Zinc	111-117	B-box 32	Arabidopsis thaliana	4-9
22786744-8	2012	However, with cyclic histatin 5, the presence of Zn(2+) ions is also necessary to fuse the peptide to the micelle.	Zinc	49-51	histatin 3	Homo sapiens	21-31
22766626-6	2012	We found that zinc(II) ions caused elevated expression             of Ki-67, a marker of proliferation, extremely low expression of p53, high expression             of Bcl-2 and no changes in the expression of p53.	Zinc	14-22	BCL2 apoptosis regulator	Homo sapiens	168-173
22837466-8	2012	Gelatinase activity was decreased in lungs from torpid animals, indicating inhibition of the Zn(2+)-dependent MMP-2 and MMP-9.	Zinc	93-99	matrix metalloproteinase-9	Mesocricetus auratus	120-125
22867434-5	2012	Conversion of 3,5-DTBC to 3,5-DTBQ catalyzed by mononuclear complexes (5-7) is observed to proceed via  formation of two enzyme-substrate adducts, ES1 and ES2, detected spectroscopically, a finding reported for the first time in any Zn(II) complex catalyzed oxidation of catechol.	Zinc	233-239	glutamine amidotransferase class 1 domain containing 3	Homo sapiens	147-150
22867434-5	2012	Conversion of 3,5-DTBC to 3,5-DTBQ catalyzed by mononuclear complexes (5-7) is observed to proceed via  formation of two enzyme-substrate adducts, ES1 and ES2, detected spectroscopically, a finding reported for the first time in any Zn(II) complex catalyzed oxidation of catechol.	Zinc	233-239	ess-2 splicing factor homolog	Homo sapiens	155-158
22869710-4	2012	EDTA removes Zn(2+) to generate apo-p53, which aggregated faster than holo-p53.	Zinc	13-15	tumor protein p53	Homo sapiens	36-39
22869710-6	2012	Apo-p53 was not an obligatory intermediate in the aggregation of holo-p53, but affords a parallel pathway that may be relevant to oncogenic mutants with impaired Zn(2+) binding.	Zinc	162-168	tumor protein p53	Homo sapiens	4-7
22713768-14	2012	By multivariate analysis in children who received ART, predictors for greater increase of CD4% from baseline were lower baseline CD4% (P&lt;0.01) and higher baseline Zn level (P=0.02).	Zinc	166-168	CD4 molecule	Homo sapiens	90-93
22803592-2	2012	To explain the structural basis of metal ion binding specificity, we have determined the X-ray structures of the N-terminal domain of calmodulin (N-CaM) in complexes with Mg(2+), Mn(2+), and Zn(2+).	Zinc	191-193	calmodulin 1	Homo sapiens	134-144
22560974-4	2012	A marked bioaccumulation of Cd, As, Hg and Zn was observed in the strain over-expressing MBP-MT in the cytoplasm, whereas Cu was accumulated to higher levels when MBP-MT was over-expressed in the periplasm.	Zinc	43-45	myelin basic protein	Ovis aries	89-92
22713768-18	2012	Higher pre-ART Zn levels were associated with significant increases in CD4% at 48 weeks.	Zinc	15-17	CD4 molecule	Homo sapiens	71-74
22639389-5	2012	The fluorescence properties of the isostructural capsules were strongly dependent on the identity of the metal species: the Zn(II) capsule emitted strong blue fluorescence with a high quantum yield (Phi=0.8), in sharp contrast to the weakly emissive Ni(II) and Mn(II) capsules and the completely non-emissive Pd(II), Pt(II), and Co(II) capsules.	Zinc	124-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	329-335
21827363-2	2012	TNF-alpha is an important proinflammatory cytokine and is released by the action of a Zn(2+)-containing converting enzyme (TACE/ADAM-17).	Zinc	86-92	tumor necrosis factor	Mus musculus	0-9
21827363-2	2012	TNF-alpha is an important proinflammatory cytokine and is released by the action of a Zn(2+)-containing converting enzyme (TACE/ADAM-17).	Zinc	86-92	a disintegrin and metallopeptidase domain 17	Mus musculus	123-127
21827363-2	2012	TNF-alpha is an important proinflammatory cytokine and is released by the action of a Zn(2+)-containing converting enzyme (TACE/ADAM-17).	Zinc	86-92	a disintegrin and metallopeptidase domain 17	Mus musculus	128-135
22706290-0	2012	Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis.	Zinc	81-83	solute carrier family 30 member 10	Homo sapiens	96-101
22706290-8	2012	We demonstrate down-regulation by Zn of ZnT10 mRNA levels in cultured intestinal and neuroblastoma cell lines and demonstrate reduced transcription from the ZnT10 promoter at an elevated extracellular Zn concentration.	Zinc	34-36	solute carrier family 30 member 10	Homo sapiens	40-45
22829296-2	2012	Metal ions (e.g. Cu, Fe, and Zn) are supposed to induce the aggregation of Abeta.	Zinc	29-31	amyloid beta precursor protein	Homo sapiens	75-80
22829296-5	2012	In this study, the binding mode of Zn(2+)-bound Abeta with bifunctional molecules was investigated by the combination of conformational sampling of full-length Abeta peptides using replica exchange molecular dynamics simulations (REMD) and conformational selection using molecular docking and classical MD simulations.	Zinc	35-37	amyloid beta precursor protein	Homo sapiens	48-53
22829296-5	2012	In this study, the binding mode of Zn(2+)-bound Abeta with bifunctional molecules was investigated by the combination of conformational sampling of full-length Abeta peptides using replica exchange molecular dynamics simulations (REMD) and conformational selection using molecular docking and classical MD simulations.	Zinc	35-37	amyloid beta precursor protein	Homo sapiens	160-165
22829296-6	2012	We demonstrate that Zn(2+)-bound Abeta((1-40)) and Abeta((1-42)) exhibit different conformational ensemble.	Zinc	20-22	amyloid beta precursor protein	Homo sapiens	33-38
22829296-6	2012	We demonstrate that Zn(2+)-bound Abeta((1-40)) and Abeta((1-42)) exhibit different conformational ensemble.	Zinc	20-22	amyloid beta precursor protein	Homo sapiens	51-56
22829296-8	2012	The bifunctional molecules exhibit their dual functions by first preferentially interfering with hydrophobic residues 17-21 and/or 30-35 of Zn(2+)-bound Abeta.	Zinc	140-142	amyloid beta precursor protein	Homo sapiens	153-158
22829296-9	2012	Additional interactions with residues surrounding Zn(2+) could possibly disrupt interactions between Zn(2+) and Abeta, which then facilitate these small molecules to chelate Zn(2+).	Zinc	50-52	amyloid beta precursor protein	Homo sapiens	112-117
22829296-9	2012	Additional interactions with residues surrounding Zn(2+) could possibly disrupt interactions between Zn(2+) and Abeta, which then facilitate these small molecules to chelate Zn(2+).	Zinc	101-103	amyloid beta precursor protein	Homo sapiens	112-117
22829296-9	2012	Additional interactions with residues surrounding Zn(2+) could possibly disrupt interactions between Zn(2+) and Abeta, which then facilitate these small molecules to chelate Zn(2+).	Zinc	101-103	amyloid beta precursor protein	Homo sapiens	112-117
22591173-2	2012	These peptides, the third zinc finger of Sp1 (Sp1-3), the second zinc finger of myelin transcription factor 1 (MyT1-2), and the second Zn-binding sequence of the DNA-binding domain of glucocorticoid receptor (GR-2), bind Zn(2+) with Cys(2)His(2), Cys(2)HisCys, and Cys(4) coordination, respectively.	Zinc	135-137	nuclear receptor subfamily 3 group C member 1	Homo sapiens	184-207
22427690-5	2012	Furthermore, the Zn(+2) region conformational p53 mutants (p53(R175H) and p53(H179R)) induced the CGS by elevating H-Ras activity.	Zinc	17-19	tumor protein p53	Homo sapiens	46-49
22427690-5	2012	Furthermore, the Zn(+2) region conformational p53 mutants (p53(R175H) and p53(H179R)) induced the CGS by elevating H-Ras activity.	Zinc	17-19	tumor protein p53	Homo sapiens	59-62
22427690-5	2012	Furthermore, the Zn(+2) region conformational p53 mutants (p53(R175H) and p53(H179R)) induced the CGS by elevating H-Ras activity.	Zinc	17-19	tumor protein p53	Homo sapiens	59-62
22564487-2	2012	In single system, equilibrium studies showed that the adsorption of Pb(II), Cu(II) and Zn(II) followed the Langmuir model and the maximum adsorption capacities were found to be 76.9, 34.5 and 20.8mg/g, respectively.	Zinc	87-93	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
22564487-3	2012	In ternary system, the combined action of the metals was found to be antagonistic and the metal sorption followed the order of Pb(II)&gt;Cu(II)&gt;Zn(II); the Langmuir isotherm fitted the data of Pb(II) and Cu(II) well while the isotherm data of Zn(II) correlated well with the Freundlich model.	Zinc	147-149	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-133
22564487-3	2012	In ternary system, the combined action of the metals was found to be antagonistic and the metal sorption followed the order of Pb(II)&gt;Cu(II)&gt;Zn(II); the Langmuir isotherm fitted the data of Pb(II) and Cu(II) well while the isotherm data of Zn(II) correlated well with the Freundlich model.	Zinc	246-248	submaxillary gland androgen regulated protein 3B	Homo sapiens	127-133
22564487-4	2012	The Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectra (XPS) studies showed that the thiol and amino group participated in the adsorption of Pb(II), Cu(II) and Zn(II).	Zinc	188-190	submaxillary gland androgen regulated protein 3B	Homo sapiens	169-175
22591173-2	2012	These peptides, the third zinc finger of Sp1 (Sp1-3), the second zinc finger of myelin transcription factor 1 (MyT1-2), and the second Zn-binding sequence of the DNA-binding domain of glucocorticoid receptor (GR-2), bind Zn(2+) with Cys(2)His(2), Cys(2)HisCys, and Cys(4) coordination, respectively.	Zinc	221-223	nuclear receptor subfamily 3 group C member 1	Homo sapiens	184-207
22591173-3	2012	Circular dichroism confirms that Sp1-3 and MyT1-2 have considerable and negligible Zn-stabilized secondary structure, respectively, and indicate only a small amount for GR-2.	Zinc	83-85	Sp1 transcription factor	Homo sapiens	33-38
22591173-3	2012	Circular dichroism confirms that Sp1-3 and MyT1-2 have considerable and negligible Zn-stabilized secondary structure, respectively, and indicate only a small amount for GR-2.	Zinc	83-85	myelin transcription factor 1	Homo sapiens	43-47
22591173-4	2012	The pK(a)"s of the Sp1-3 cysteines and histidines were determined by NMR and used to estimate the number of protons displaced by Zn(2+) at pH 7.4.	Zinc	129-131	Sp1 transcription factor	Homo sapiens	19-24
22591173-6	2012	Subtraction of buffer contributions to the calorimetric data reveals that all three peptides have a similar affinity for Zn(2+), which has equal enthalpy and entropy components for Sp1-3 but is more enthalpically disfavored and entropically favored with increasing Cys ligands.	Zinc	121-123	Sp1 transcription factor	Homo sapiens	181-186
22588053-0	2012	Effect of Zn impurity in K0.8Fe(2-delta-x)Zn(x)Se2.	Zinc	10-12	fucosyltransferase 2	Homo sapiens	47-50
21906406-8	2012	The expression levels of the Zn transporters Zip4 and ZnT1 in the intestinal epithelium were significantly lower in rats fed a diet supplemented with 1016 mg/kg Zn compared to those fed the basal diet.	Zinc	29-31	solute carrier family 39 member 4	Rattus norvegicus	45-49
22523284-5	2012	Addition of 10 muM zinc to serum-free medium of SPAEC increased [ Zn ] (i) and abolished LPS-induced apoptosis (e.g., increased annexin V binding).	Zinc	66-68	latexin	Homo sapiens	15-18
22367497-6	2012	Excess of Zn(2+) also induced activation of the initiator caspase Dronc, associated with the mitochondrial pathway of PCD, and the effector caspase DrICE.	Zinc	10-12	Death related ced-3/Nedd2-like caspase	Drosophila melanogaster	58-65
22367497-6	2012	Excess of Zn(2+) also induced activation of the initiator caspase Dronc, associated with the mitochondrial pathway of PCD, and the effector caspase DrICE.	Zinc	10-12	Death related ced-3/Nedd2-like caspase	Drosophila melanogaster	140-147
22640423-8	2012	Analysis of Zn2+ showed that levels were increased in both soluble fractions and synaptic vesicles in AD hippocampi, paralleled by a decrease of expression of the synaptic vesicle Zn2+ transporter, ZnT3.	Zinc	12-16	solute carrier family 30 member 3	Homo sapiens	198-202
22281551-1	2012	An equimolar reaction between ZnEt(2) and 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine (hppH) results in the formation of EtZn(hpp) (1) which crystallizes as a trinuclear agglomerate with the guanidinate ligands spanning 4-coordinate Zn centers.	Zinc	30-32	familial progressive hyperpigmentation 1	Homo sapiens	94-97
22625223-5	2012	RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P &lt; 0.001), IGF-1 (P &lt; 0.01), IGF-1 standard deviation score (SDS, P &lt; 0.01) and IGFBP-3 (P = 0.042).	Zinc	27-29	insulin like growth factor 1	Homo sapiens	183-188
22625223-5	2012	RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P &lt; 0.001), IGF-1 (P &lt; 0.01), IGF-1 standard deviation score (SDS, P &lt; 0.01) and IGFBP-3 (P = 0.042).	Zinc	27-29	insulin like growth factor 1	Homo sapiens	204-209
22625223-8	2012	CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.	Zinc	75-77	insulin like growth factor 1	Homo sapiens	18-23
22625223-8	2012	CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.	Zinc	110-112	insulin like growth factor 1	Homo sapiens	18-23
22332887-4	2012	We now describe the lack of disease in mice that express a variant of human SOD1 in which residues that coordinate the binding of Cu and Zn have been mutated (SODMD).	Zinc	137-139	superoxide dismutase 1	Homo sapiens	76-80
22519733-0	2012	Imino-phenolic-pyridyl conjugates of calix[4]arene (L1 and L2) as primary fluorescence switch-on sensors for Zn2+ in solution and in HeLa cells and the recognition of pyrophosphate and ATP by [ZnL2].	Zinc	109-113	L1 cell adhesion molecule	Homo sapiens	52-61
22344792-2	2012	Motoneuron damage in the facial nuclei after facial nerve avulsion is accelerated in presymptomatic transgenic rats expressing human mutant Cu(2+) /Zn(2+) superoxide dismutase 1 (SOD1), compared with that in wild-type rats.	Zinc	148-150	superoxide dismutase 1	Homo sapiens	179-183
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	Zinc	143-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
21939673-3	2012	Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.	Zinc	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	151-155
22530682-3	2012	We have previously shown that topical application of zinc-metallothionein-IIA (Zn(7) -MT-IIA) accelerates healing following burn injury, and here, we investigated the potential of Zn(7) -MT-IIA to enhance reinnervation and sensory recovery.	Zinc	79-81	ATPase, class II, type 9A	Mus musculus	74-77
22530682-3	2012	We have previously shown that topical application of zinc-metallothionein-IIA (Zn(7) -MT-IIA) accelerates healing following burn injury, and here, we investigated the potential of Zn(7) -MT-IIA to enhance reinnervation and sensory recovery.	Zinc	79-81	ATPase, class II, type 9A	Mus musculus	89-92
22530682-3	2012	We have previously shown that topical application of zinc-metallothionein-IIA (Zn(7) -MT-IIA) accelerates healing following burn injury, and here, we investigated the potential of Zn(7) -MT-IIA to enhance reinnervation and sensory recovery.	Zinc	79-81	ATPase, class II, type 9A	Mus musculus	89-92
22248233-6	2012	The effects on FOXO1a and gluconeogenic gene expression require the presence of Zn2+ ions, reminiscent of much earlier studies examining diabetogenic properties of 8-hydroxyquinolines.	Zinc	80-84	forkhead box O1	Homo sapiens	15-21
22754403-5	2012	We find that polarization effect plays a determining role in Zn(2+) coordination geometry in both matrix metalloproteinase (MMP) complexes and in zinc-finger proteins.	Zinc	61-67	matrix metallopeptidase 13	Homo sapiens	124-127
22366383-1	2012	Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (Abeta) plaques within the brain of Alzheimer"s disease (AD).	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	63-75
22366383-1	2012	Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (Abeta) plaques within the brain of Alzheimer"s disease (AD).	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	77-82
22482427-6	2012	Gel mobility shift assays showed that the Zn(II)-bound forms of the ligand-substituted derivatives retain DNA binding ability, while the DNA binding affinity decreased in the following manner: CCHH &gt; CDHH &gt; CEHH &gt;&gt; CHHH.	Zinc	42-48	cadherin 13	Homo sapiens	203-207
22452395-1	2012	Abnormal interactions of Cu and Zn ions with the amyloid beta (Abeta) peptide are proposed to play an important role in the pathogenesis of Alzheimer"s disease (AD).	Zinc	32-34	amyloid beta precursor protein	Homo sapiens	49-61
22452395-1	2012	Abnormal interactions of Cu and Zn ions with the amyloid beta (Abeta) peptide are proposed to play an important role in the pathogenesis of Alzheimer"s disease (AD).	Zinc	32-34	amyloid beta precursor protein	Homo sapiens	63-68
22365362-1	2012	In this study, a CdSe/ZnS quantum dot (QD)-based immunosensor using a simple optical system for human serum albumin (HSA) detection is developed.	Zinc	22-25	albumin	Homo sapiens	102-115
22589106-6	2012	We applied this methodology to SOD1, wild-type, and Ala4Val mutant (A4V), a mutation found in amyotrophic lateral sclerosis (ALS) because decreased Zn affinity to SOD1 mutants is suggested to be involved in the pathogenesis of this neurodegenerative disease.	Zinc	148-150	superoxide dismutase 1	Homo sapiens	31-35
22357343-5	2012	Three types of self-association have been characterized: dimers of human GH that form with Zn(2+), low-affinity self-association of human prolactin caused by acidic pH and Zn(2+) with macromolecular crowding, and amyloid fibers of prolactin.	Zinc	172-174	prolactin	Homo sapiens	138-147
21702047-7	2012	Our data suggest that Zip5, Zip8, and Zip10 may be key to Zn acquisition from maternal circulation, while multiple Zip proteins reuptake Zn from milk.	Zinc	58-60	solute carrier family 39 (metal ion transporter), member 5	Mus musculus	22-26
21935692-8	2012	Expression of PARP, p53 and OGG1 measured by western blotting was increased in Zn-depleted cells indicating that DNA repair mechanisms are activated.	Zinc	79-81	poly(ADP-ribose) polymerase 1	Homo sapiens	14-18
21935692-8	2012	Expression of PARP, p53 and OGG1 measured by western blotting was increased in Zn-depleted cells indicating that DNA repair mechanisms are activated.	Zinc	79-81	tumor protein p53	Homo sapiens	20-23
22370740-9	2012	Characterization by ESI-MS spectrometry and CD and UV-visible spectrophotometry of the Zn(II)-, Cd(II)- and Cu(I)-MtnE complexes obtained by recombinant synthesis demonstrates that MtnE is the least metal-specific isoform of the Drosophila MTs, and therefore it could play a role when/where a broad spectrum of metal coordination abilities are advantageous in terms of physiological needs.	Zinc	87-93	Metallothionein E	Drosophila melanogaster	114-118
22370740-9	2012	Characterization by ESI-MS spectrometry and CD and UV-visible spectrophotometry of the Zn(II)-, Cd(II)- and Cu(I)-MtnE complexes obtained by recombinant synthesis demonstrates that MtnE is the least metal-specific isoform of the Drosophila MTs, and therefore it could play a role when/where a broad spectrum of metal coordination abilities are advantageous in terms of physiological needs.	Zinc	87-93	Metallothionein E	Drosophila melanogaster	181-185
22275360-3	2012	Employing metal buffering for strict metal control and performing a kinetic analysis, we now demonstrate that zinc(II) ions are reversible inhibitors of the cytoplasmic catalytic domain of the receptor protein-tyrosine phosphatase beta (also known as vascular endothelial protein-tyrosine phosphatase).	Zinc	110-118	protein tyrosine phosphatase receptor type B	Homo sapiens	251-300
22303956-9	2012	A direct inhibition of MGST1 by Zn(2+) could provide a possible explanation for the lack of protection against ZnO nanoparticles in this model.	Zinc	32-34	microsomal glutathione S-transferase 1	Homo sapiens	23-28
22423218-7	2012	The d isomer forms channel-like pores with heterogeneous ionic conductance similar to the l-Abeta isomer channels, and the d-isomer channel conductance is blocked by Zn(2+), a known blocker of l-Abeta isomer channels.	Zinc	166-168	amyloid beta precursor protein	Homo sapiens	92-97
22344939-1	2012	Mesoporous silica metal oxide (ZnO and CdO) thin films have been used as metal ion precursors to produce the first examples of mesoporous silica metal sulfide (meso-SiO(2) @ZnS, meso-SiO(2) @CdS) or silica metal selenide (meso-SiO(2) @ZnSe, meso-SiO(2) @CdSe) thin films, in which the pore walls are made up of silica and metal sulfide or metal selenide nanoflakes, respectively.	Zinc	173-176	cell adhesion associated, oncogene regulated	Homo sapiens	39-42
22423218-7	2012	The d isomer forms channel-like pores with heterogeneous ionic conductance similar to the l-Abeta isomer channels, and the d-isomer channel conductance is blocked by Zn(2+), a known blocker of l-Abeta isomer channels.	Zinc	166-168	amyloid beta precursor protein	Homo sapiens	195-200
22318122-2	2012	Here, we describe extensive alterations of ZnT3-regulated Zn pools in the brains of human amyloid precursor protein-transgenic (Tg2576) mice.	Zinc	43-45	amyloid beta precursor protein	Homo sapiens	90-115
22108899-9	2012	Furthermore, Al treatment increased the protein expression of GSK3 and decreased the PP1 expression, which were found to be reversed upon Zn administration.	Zinc	138-140	neuropeptide Y receptor Y4	Rattus norvegicus	85-88
22244881-11	2012	Apocynin and/or NAC also mitigated Zn- and PQ-induced alterations in oxidative stress, NADPH oxidase activation and cytochrome c release, caspases-9 and -3 activation and CD11b expression.	Zinc	35-37	integrin subunit alpha M	Rattus norvegicus	171-176
22250969-11	2012	The existence of two distinct conformers of Zn-bound P450(cam) is consistent with the findings of Goodin and co-workers [Lee, Y.-T., et al.	Zinc	44-46	calmodulin 3	Homo sapiens	58-61
22263642-4	2012	Moreover, the dynamics of the insulin protein showed a dependence on the concentration of Zn(II) ions.	Zinc	90-96	insulin	Homo sapiens	30-37
22264081-3	2012	The presence of stabilizing Brij 76 surfactant and Zn(II) ions allowed the detection of weak protein complexes, such as alpha1-antitrypsin-trypsin and IgG-protein G complexes, at the picomole level.	Zinc	51-57	serpin family A member 1	Homo sapiens	120-138
22261248-6	2012	Furthermore our data demonstrated that Zn2+-induced ubiquitination requires p38 activation.	Zinc	39-43	mitogen-activated protein kinase 14	Homo sapiens	76-79
22206974-3	2012	The experimental results show that the PSMA resin-Pb equilibrium was achieved in 2 min and the Pb(II) loading capacity is up to 641.62 mg g(-1) in aqueous solution under optimum conditions, which is much higher than the Zn(II) loading capacity within 80 min.	Zinc	220-226	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
22206974-4	2012	The adsorption test for Pb(II) indicates that PSMA can recover Pb(II) from a mixed solution of Pb(II), Zn(II) and light metals such as Ca(II) and Mg(II) with higher adsorption rate and larger selective coefficient.	Zinc	103-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	63-69
22206974-4	2012	The adsorption test for Pb(II) indicates that PSMA can recover Pb(II) from a mixed solution of Pb(II), Zn(II) and light metals such as Ca(II) and Mg(II) with higher adsorption rate and larger selective coefficient.	Zinc	103-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	63-69
22242602-2	2012	We report that human metallothionein 1a, well-known to coordinate 7 Zn(2+) or Cd(2+) ions with 20 cysteinyl thiols, will bind 8 structurally significant Cd(2+) ions, leading to the formation of the supermetalated Cd(8)-betaalpha-rhMT 1a species, for which the structure is a novel single domain.	Zinc	68-70	metallothionein 1A	Homo sapiens	21-39
22186999-2	2012	L has been shown to act as selective ratiometric turn-on fluorescence sensor for Zn(2+) up to a lowest concentration of 183 +- 18 ppb (2.82 muM) with a nine-fold enhancement by exhibiting blue-green emission.	Zinc	81-83	latexin	Homo sapiens	140-143
22317921-3	2012	We show that phosphorylation of evolutionarily conserved residues in endoplasmic reticulum zinc channel ZIP7 is associated with the gated release of Zn(2+) from intracellular stores, leading to activation of tyrosine kinases and the phosphorylation of AKT and extracellular signal-regulated kinases 1 and 2.	Zinc	149-151	AKT serine/threonine kinase 1	Homo sapiens	252-255
22317921-3	2012	We show that phosphorylation of evolutionarily conserved residues in endoplasmic reticulum zinc channel ZIP7 is associated with the gated release of Zn(2+) from intracellular stores, leading to activation of tyrosine kinases and the phosphorylation of AKT and extracellular signal-regulated kinases 1 and 2.	Zinc	149-151	mitogen-activated protein kinase 3	Homo sapiens	260-306
22374397-2	2012	Arabidopsis thaliana ZINC-INDUCED FACILITATOR1 (ZIF1) is a vacuolar membrane major facilitator superfamily protein required for basal Zn tolerance.	Zinc	134-136	zinc induced facilitator 1	Arabidopsis thaliana	21-46
22024135-3	2012	Our group has demonstrated that Zn, when co-administered with LPS in early pregnancy in mice (gestation day (GD) 8), prevents fetal malformations and neurodevelopmental deficits in offspring.	Zinc	32-34	toll-like receptor 4	Mus musculus	62-65
22024135-10	2012	Coincidentally, the fetuses of LPS-treated dams showed astrogliosis, extensive cell death and an increased number of cells producing TNF-alpha which was prevented with concomitant Zn treatment.	Zinc	180-182	toll-like receptor 4	Mus musculus	31-34
22024135-10	2012	Coincidentally, the fetuses of LPS-treated dams showed astrogliosis, extensive cell death and an increased number of cells producing TNF-alpha which was prevented with concomitant Zn treatment.	Zinc	180-182	tumor necrosis factor	Mus musculus	133-142
22277170-1	2012	Zn plays a key role in the synthesis and action of insulin.	Zinc	0-2	insulin	Homo sapiens	51-58
22277170-2	2012	The aim of the present work was to determine whether a poorer Zn status was associated with insulin resistance in a group of 357 Spanish schoolchildren.	Zinc	62-64	insulin	Homo sapiens	92-99
22277170-8	2012	The risk of having a greater insulin resistance value (HOMA greater than the 75th percentile) increased with age (OR 1 438; 95 % CI 1 021, 2 027) and BMI (OR 1 448; 95 % CI 1 294, 1 619) and decreased as Zn serum levels increased (OR 0 908; 95 % CI 0 835, 0 987; P &lt; 0 001).	Zinc	204-206	insulin	Homo sapiens	29-36
22277170-10	2012	Taking into account that Zn intake was below than that recommended in 89 4 % of the children, it would appear that increasing the intake of Zn could improve the health and nutritional status of these children, and thus contribute to diminish problems of insulin resistance.	Zinc	140-142	insulin	Homo sapiens	254-261
22374397-2	2012	Arabidopsis thaliana ZINC-INDUCED FACILITATOR1 (ZIF1) is a vacuolar membrane major facilitator superfamily protein required for basal Zn tolerance.	Zinc	134-136	zinc induced facilitator 1	Arabidopsis thaliana	48-52
22374397-3	2012	Here, we show that overexpression of ZIF1 enhances the partitioning into vacuoles of the low molecular mass metal chelator nicotianamine and leads to pronounced nicotianamine accumulation in roots, accompanied by vacuolar buildup of Zn.	Zinc	233-235	zinc induced facilitator 1	Arabidopsis thaliana	37-41
22374397-4	2012	Heterologous ZIF1 protein localizes to vacuolar membranes and enhances nicotianamine contents of yeast cells engineered to synthesize nicotianamine, without complementing a Zn-hypersensitive mutant that additionally lacks vacuolar membrane Zn(2+)/H(+) antiport activity.	Zinc	173-175	zinc induced facilitator 1	Arabidopsis thaliana	13-17
22374397-4	2012	Heterologous ZIF1 protein localizes to vacuolar membranes and enhances nicotianamine contents of yeast cells engineered to synthesize nicotianamine, without complementing a Zn-hypersensitive mutant that additionally lacks vacuolar membrane Zn(2+)/H(+) antiport activity.	Zinc	240-242	zinc induced facilitator 1	Arabidopsis thaliana	13-17
22374397-5	2012	Retention in roots of Zn, but not of Fe, is enhanced in ZIF1 overexpressors at the expense of the shoots.	Zinc	22-24	zinc induced facilitator 1	Arabidopsis thaliana	56-60
22374397-8	2012	The zif1 mutant is also hypersensitive to Fe deficiency, even in media lacking added Zn.	Zinc	85-87	zinc induced facilitator 1	Arabidopsis thaliana	4-8
22374397-9	2012	Therefore, accurate levels of ZIF1 expression are critical for both Zn and Fe homeostasis.	Zinc	68-70	zinc induced facilitator 1	Arabidopsis thaliana	30-34
22129241-4	2012	The insulin analogues were formulated with Zn(II) and phenol to form hexamers.	Zinc	43-49	insulin	Homo sapiens	4-11
22175799-0	2012	Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.	Zinc	34-36	matrix metallopeptidase 13	Homo sapiens	58-85
22175799-0	2012	Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.	Zinc	34-36	matrix metallopeptidase 13	Homo sapiens	87-93
22116833-6	2012	Detection limits of 0.05, 0.09 and 2.2 ng mL(-1) Cd(II), Pb(II) and Zn(II) were established with an accumulation time of 65 s. The method is used for the analysis of Cd(II), Pb(II) and Zn(II) in different water samples, certified reference materials, and saliva samples with satisfactory results.	Zinc	68-74	submaxillary gland androgen regulated protein 3B	Homo sapiens	174-180
22116833-6	2012	Detection limits of 0.05, 0.09 and 2.2 ng mL(-1) Cd(II), Pb(II) and Zn(II) were established with an accumulation time of 65 s. The method is used for the analysis of Cd(II), Pb(II) and Zn(II) in different water samples, certified reference materials, and saliva samples with satisfactory results.	Zinc	185-191	submaxillary gland androgen regulated protein 3B	Homo sapiens	57-63
22059434-1	2012	The aggregation of insulin is complicated by the coexistence of various multimers, especially in the presence of Zn(2+).	Zinc	113-115	insulin	Homo sapiens	19-26
22059434-8	2012	The much greater aggregation rate and limiting turbidity (tau( )) for the Zn-insulin hexamer relative to the Zn-free dimer was explained by their different aggregation mechanisms.	Zinc	74-76	insulin	Homo sapiens	77-84
22059434-8	2012	The much greater aggregation rate and limiting turbidity (tau( )) for the Zn-insulin hexamer relative to the Zn-free dimer was explained by their different aggregation mechanisms.	Zinc	109-111	insulin	Homo sapiens	77-84
22059434-9	2012	Sequential first-order kinetic regimes and the concentration dependence of tau( ) for the Zn-insulin hexamer indicate a nucleation and growth mechanism, as proposed by Wang and Kurganov (Wang, K.; Kurganov, B. I. Biophys.	Zinc	90-92	insulin	Homo sapiens	93-100
22129241-9	2012	This hierarchical self-assembly system, which combines Zn(II) mediated hexamer formation with fluorous interactions, is a promising tool to control the formation of high molecular weight complexes of insulin and potentially other proteins.	Zinc	55-61	insulin	Homo sapiens	200-207
22349685-2	2012	Zn2+ can accelerate assembly of the amyloid-beta peptides (Abeta) and tau protein central to the neuropathological changes found in Alzheimer"s disease (AD).	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	59-64
22834550-5	2012	Zn pre-treatment tended to improve body weight gain (P=0.072) in the starter period, to increase the activity of ileal sucrase (P=0.077), to reduce plasma endotoxin levels (P=0.080), and to significantly increase (P&lt;0.05) the villus height/crypt depth ratio and mRNA levels of occludin and claudin-1 in the ileum at day 21.	Zinc	0-2	occludin	Gallus gallus	280-288
22834550-5	2012	Zn pre-treatment tended to improve body weight gain (P=0.072) in the starter period, to increase the activity of ileal sucrase (P=0.077), to reduce plasma endotoxin levels (P=0.080), and to significantly increase (P&lt;0.05) the villus height/crypt depth ratio and mRNA levels of occludin and claudin-1 in the ileum at day 21.	Zinc	0-2	claudin 1	Gallus gallus	293-302
22834550-6	2012	The results indicated that dietary Zn supplementation appeared to alleviate the loss of intestinal mucosal barrier function induced by S. Typhimurium challenge and the partial mechanism might be related to the increased expression of occludin and claudin-1 in broiler chickens.	Zinc	35-37	occludin	Gallus gallus	234-242
22834550-6	2012	The results indicated that dietary Zn supplementation appeared to alleviate the loss of intestinal mucosal barrier function induced by S. Typhimurium challenge and the partial mechanism might be related to the increased expression of occludin and claudin-1 in broiler chickens.	Zinc	35-37	claudin 1	Gallus gallus	247-256
23207768-5	2012	Despite metal ion-dependent restoration of the inhibited HIF-1alpha hydroxylase activity, the cellular HIF-1alpha-inducing effects of the CQ analogues are reversed to varying degrees by Zn(2+) and Fe(2+).	Zinc	186-188	hypoxia inducible factor 1 alpha subunit	Gallus gallus	103-113
23207768-8	2012	These phenomena are found to coincide with elevation of the intracellular Zn(2+) and Fe(2+) levels by the CQ analogues, suggesting that metal ion effects on HIF-1alpha in cells likely reflect the differential transporting capability of the analogues.	Zinc	74-80	hypoxia inducible factor 1 alpha subunit	Gallus gallus	157-167
22138653-1	2012	A growing body of Alzheimer"s disease (AD) research is concerned with understanding the interaction between amyloid-beta (Abeta) peptides and metal ions (e.g., Cu, Zn, and Fe) and determining the biological relevance of the metal-Abeta complexes to essential metal homeostasis and neuronal cell loss.	Zinc	164-166	amyloid beta precursor protein	Homo sapiens	108-120
22138653-1	2012	A growing body of Alzheimer"s disease (AD) research is concerned with understanding the interaction between amyloid-beta (Abeta) peptides and metal ions (e.g., Cu, Zn, and Fe) and determining the biological relevance of the metal-Abeta complexes to essential metal homeostasis and neuronal cell loss.	Zinc	164-166	amyloid beta precursor protein	Homo sapiens	122-127
22349685-10	2012	These expression changes could either reflect or cause the altered cortical Zn2+ distribution in AD, potentially increasing the likelihood of interactions between Zn2+ and Abeta or tau protein.	Zinc	76-80	amyloid beta precursor protein	Homo sapiens	172-177
21603979-6	2012	Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn(2+) influx and sequestration in RPE cells.	Zinc	180-182	solute carrier family 39 member 2	Homo sapiens	18-22
21833656-2	2012	The Cu(II) and Zn(II) complexes could differentiate the palindromic sequences 5"-CATATG-3" and 5"-GTATAC-3", whereas the Co(II) analogue could not.	Zinc	15-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
23251339-10	2012	CONCLUSIONS: Zn is required for maintaining Akt activation by inhibiting the expression of Akt negative regulators; Akt activation can inhibit Fyn nuclear translocation to export nuclear Nrf2 to cytoplasm for degradation.	Zinc	13-15	thymoma viral proto-oncogene 1	Mus musculus	91-94
23236296-0	2012	Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana.	Zinc	99-101	MATE efflux family protein	Arabidopsis thaliana	25-29
23251339-10	2012	CONCLUSIONS: Zn is required for maintaining Akt activation by inhibiting the expression of Akt negative regulators; Akt activation can inhibit Fyn nuclear translocation to export nuclear Nrf2 to cytoplasm for degradation.	Zinc	13-15	thymoma viral proto-oncogene 1	Mus musculus	44-47
23236296-4	2012	Fine-scale mapping showed that a variant of the Fe homeostasis-related FERRIC REDUCTASE DEFECTIVE3 (FRD3) gene, which encodes a multidrug and toxin efflux (MATE) transporter, is responsible for reduced Zn tolerance in A. thaliana.	Zinc	202-204	MATE efflux family protein	Arabidopsis thaliana	71-98
23236296-4	2012	Fine-scale mapping showed that a variant of the Fe homeostasis-related FERRIC REDUCTASE DEFECTIVE3 (FRD3) gene, which encodes a multidrug and toxin efflux (MATE) transporter, is responsible for reduced Zn tolerance in A. thaliana.	Zinc	202-204	MATE efflux family protein	Arabidopsis thaliana	100-104
23236296-7	2012	Our results suggest that FRD3 works as a multimer and is involved in loading Zn into xylem.	Zinc	77-79	MATE efflux family protein	Arabidopsis thaliana	25-29
23251339-10	2012	CONCLUSIONS: Zn is required for maintaining Akt activation by inhibiting the expression of Akt negative regulators; Akt activation can inhibit Fyn nuclear translocation to export nuclear Nrf2 to cytoplasm for degradation.	Zinc	13-15	thymoma viral proto-oncogene 1	Mus musculus	91-94
23251339-10	2012	CONCLUSIONS: Zn is required for maintaining Akt activation by inhibiting the expression of Akt negative regulators; Akt activation can inhibit Fyn nuclear translocation to export nuclear Nrf2 to cytoplasm for degradation.	Zinc	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	187-191
23251339-11	2012	Zn deficiency significantly enhanced diabetes-induced hepatic injury likely through down-regulation of Nrf2 function.	Zinc	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
22916096-10	2012	Zn(II) binds to transferrin and diminishes its Fe(III) incorporation capacity and rate but it does not specifically bind to a putative ferroxidase site of FD1.	Zinc	0-6	transferrin	Homo sapiens	16-27
23209723-2	2012	It"s been reported that an acute decrease in ZnT8 levels impairs beta cell function and Zn(++) homeostasis, which contribute to the pathophysiology of diabetes mellitus (DM).	Zinc	88-94	solute carrier family 30 (zinc transporter), member 8	Mus musculus	45-49
23209723-9	2012	Our data indicate that ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a neuroprotective role against ischemic insult.	Zinc	71-77	solute carrier family 30 (zinc transporter), member 8	Mus musculus	100-104
23173058-2	2012	Here we describe the development of new sensors for Zn2+based on alternate FRET-pairs that do not involve the traditional CFP and YFP.	Zinc	52-56	complement factor properdin	Homo sapiens	122-125
23133519-4	2012	This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression.	Zinc	5-11	anoctamin 1, calcium activated chloride channel	Mus musculus	68-75
23133519-4	2012	This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression.	Zinc	5-11	anoctamin 1, calcium activated chloride channel	Mus musculus	119-126
22558227-5	2012	When co-incubated with Zn(2+) or Cu(2+), Abeta(D7H) aggregated into low molecular weight oligomers.	Zinc	23-25	amyloid beta precursor protein	Homo sapiens	41-46
22558346-0	2012	Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation.	Zinc	70-74	superoxide dismutase 1	Homo sapiens	16-38
22558227-7	2012	Although the pathogenic nature of this mutation needs further confirmation, our findings suggest that the Abeta N-terminal region potentially modulates APP processing and Abeta aggregation, and further provides a genetic indication of the importance of Zn(2+) and Cu(2+) in the etiology of AD.	Zinc	253-255	amyloid beta precursor protein	Homo sapiens	106-111
22121028-4	2012	Furthermore, there was a large difference in the 1-D migration patterns of phosphorylated species of extracellular signal-regulated kinases 1 and 2 (ERK1/2, 44/42 kDa), which arise from changes in the phosphorylation status of the Thr-202 and Tyr-204, in the two buffer systems at the same concentration of Zn(2+)-Phos-tag.	Zinc	307-313	mitogen-activated protein kinase 1	Homo sapiens	101-147
22121028-4	2012	Furthermore, there was a large difference in the 1-D migration patterns of phosphorylated species of extracellular signal-regulated kinases 1 and 2 (ERK1/2, 44/42 kDa), which arise from changes in the phosphorylation status of the Thr-202 and Tyr-204, in the two buffer systems at the same concentration of Zn(2+)-Phos-tag.	Zinc	307-313	mitogen-activated protein kinase 3	Homo sapiens	149-155
23023423-4	2012	We reported that Zn complexes with coordinating sulfur atom exhibit higher insulin-mimetic activity.	Zinc	17-19	insulin	Homo sapiens	75-82
21984481-6	2012	The sensitivity of mercury to TRPC5 is presumed to be specific because other divalent heavy metal pollutants, such as Cd(2+), Ni(2+), and Zn(2+), had no stimulating effect, and TRPC3, TRPC6, TRPV1, and TRPM2 were resistant to mercurial compounds.	Zinc	138-140	transient receptor potential cation channel subfamily C member 5	Homo sapiens	30-35
22261072-1	2011	Observations like high Zn(2+) concentrations in senile plaques found in the brains of Alzheimer"s patients and evidences emphasizing the role of Zn(2+) in amyloid-beta (Abeta)-induced toxicity have triggered wide interest in understanding the nature of Zn(2+)-Abeta interaction.	Zinc	23-29	amyloid beta precursor protein	Homo sapiens	169-174
21996590-5	2011	The model calculations predicted pseudo octahedral trans-[M(CCA2)(2)(H(2)O)(2)] structures for the Zn(II), Ni(II) and Co(II) complexes and a binuclear [Mn(2)(CCA2)(4)(H(2)O)(2)] structure.	Zinc	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-124
22261072-1	2011	Observations like high Zn(2+) concentrations in senile plaques found in the brains of Alzheimer"s patients and evidences emphasizing the role of Zn(2+) in amyloid-beta (Abeta)-induced toxicity have triggered wide interest in understanding the nature of Zn(2+)-Abeta interaction.	Zinc	23-25	amyloid beta precursor protein	Homo sapiens	169-174
22261072-1	2011	Observations like high Zn(2+) concentrations in senile plaques found in the brains of Alzheimer"s patients and evidences emphasizing the role of Zn(2+) in amyloid-beta (Abeta)-induced toxicity have triggered wide interest in understanding the nature of Zn(2+)-Abeta interaction.	Zinc	145-151	amyloid beta precursor protein	Homo sapiens	169-174
22261072-2	2011	In vivo and in vitro studies have shown that aggregation kinetics, toxicity, and morphology of Abeta aggregates are perturbed in the presence of Zn(2+).	Zinc	145-147	amyloid beta precursor protein	Homo sapiens	95-100
22261072-3	2011	Structural studies have revealed that Zn(2+) has a binding site in the N-terminal region of monomeric Abeta, but not much is precisely known about the nature of binding of Zn(2+) with aggregated forms of Abeta or its effect on the molecular structure of these aggregates.	Zinc	38-40	amyloid beta precursor protein	Homo sapiens	102-107
22071077-0	2011	The in vitro glycation of human serum albumin in the presence of Zn(II).	Zinc	65-71	albumin	Homo sapiens	32-45
21864503-3	2011	Hence, HEK-TRPC6 cells have larger pools of mobilizable Zn2+ and are more sensitive to an oxidative stress.	Zinc	56-60	EPH receptor A3	Homo sapiens	7-16
21258970-11	2011	In patients with advanced CHF, irrespective of the rhythm, profound hypozincemia, and a decreased Zn/Cu ratio were present, which could be secondary to the activation of the renin-angiotensin-aldosterone system and CHF medications.	Zinc	98-100	renin	Homo sapiens	174-179
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	114-116	latexin	Homo sapiens	175-178
21563269-3	2011	The purpose of this study was to investigate the effect of Zn on alkaline phosphatase (ALP) activity of osteoblasts and in the initial biological MVs-mediated mineral deposition.	Zinc	59-61	alkaline phosphatase, placental	Homo sapiens	65-85
21563269-3	2011	The purpose of this study was to investigate the effect of Zn on alkaline phosphatase (ALP) activity of osteoblasts and in the initial biological MVs-mediated mineral deposition.	Zinc	59-61	alkaline phosphatase, placental	Homo sapiens	87-90
21563269-8	2011	RESULTS: The ALP activity of osteoblasts in culture medium supplemented with 1 x 10(-5) M of Zn was significantly increased at both five and seven days.	Zinc	93-95	alkaline phosphatase, placental	Homo sapiens	13-16
21563269-11	2011	CONCLUSIONS: The proper concentration of Zn increased the ALP activity of osteoblasts after five and seven days of incubation.	Zinc	41-43	alkaline phosphatase, placental	Homo sapiens	58-61
21563269-12	2011	The present XRF and EDX data suggest that the increase of mineral deposition with Zn exposure for one to five days might be mediated by the activation of ALP and calcium-binding proteins.	Zinc	82-84	alkaline phosphatase, placental	Homo sapiens	154-157
21953456-3	2011	Using nucleotide extension efficiency as a readout, Zn(2+) showed significant inhibition of reactions with 2 mM Mg(2+), even when present at only ~5 muM.	Zinc	52-58	latexin	Homo sapiens	149-152
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	114-116	latexin	Homo sapiens	286-289
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	151-153	latexin	Homo sapiens	175-178
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	151-153	latexin	Homo sapiens	286-289
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	151-153	latexin	Homo sapiens	175-178
21913678-3	2011	The developed probe gave a good linearity for the calibration plot (the recovered PL intensity of the SiO(2)-S-Mn-ZnS QDs against the concentration of Zn(2+) from 0.3 to 15.0 muM), excellent reproducibility (1.2% relative standard deviation for 11 replicate measurements of Zn(2+) at 3 muM), and low detection limit (3s; 80 nM Zn(2+)).	Zinc	151-153	latexin	Homo sapiens	286-289
22056667-0	2011	Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.	Zinc	37-39	lysine demethylase 6A	Homo sapiens	88-91
22056667-0	2011	Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.	Zinc	37-39	lysine demethylase 6A	Homo sapiens	92-127
21945651-0	2011	Recombinant human erythropoietin reduces aggregation of mutant Cu/Zn-binding superoxide dismutase (SOD1) in NSC-34 cells.	Zinc	66-68	erythropoietin	Homo sapiens	18-32
21945651-0	2011	Recombinant human erythropoietin reduces aggregation of mutant Cu/Zn-binding superoxide dismutase (SOD1) in NSC-34 cells.	Zinc	66-68	superoxide dismutase 1	Homo sapiens	99-103
20213444-13	2011	It forms complexes with Zn(2+) and, by chelating Zn(2+), S100A12 significantly inhibits MMPs.	Zinc	24-26	S100 calcium binding protein A12	Homo sapiens	57-64
21835544-2	2011	The selectivity order of the resin towards some metal ions follows the order Pb(II) &gt; Cu(II)&gt; Zn(II), Ni(II), Co(II).	Zinc	100-106	submaxillary gland androgen regulated protein 3B	Homo sapiens	77-83
21945443-3	2011	The yeast transformants expressing AtCCX5 were created and their growth in the presence of various cations (K(+), Na(+), Ca(2+), Mg(2+), Fe(2+), Cu(2+), Co(2+), Cd(2+), Mn(2+), Ba(2+), Ni(2+), Zn(2+), and Li(+)) were analyzed.	Zinc	193-195	cation exchanger 11	Arabidopsis thaliana	35-41
21945443-5	2011	The AtCCX5 transformant also showed a little better growth to Zn(2+).	Zinc	62-64	cation exchanger 11	Arabidopsis thaliana	4-10
20213444-13	2011	It forms complexes with Zn(2+) and, by chelating Zn(2+), S100A12 significantly inhibits MMPs.	Zinc	49-51	S100 calcium binding protein A12	Homo sapiens	57-64
20213444-14	2011	Zn(2+) in S100A12 complexes co-localize with MMP-9 in foam cells in atheroma.	Zinc	0-2	S100 calcium binding protein A12	Homo sapiens	10-17
21972134-8	2011	A function-abolishing mutation of the Zn(2+)-binding motif of NRD did not affect the potentiation by tubulin.	Zinc	38-44	nardilysin convertase	Homo sapiens	62-65
21660051-5	2011	Silencing of GSK-3beta or p53 expression was cardioprotective, indicating that activation of the ERK-GSK-3beta-p53 signaling pathway is involved in Zn(2+)-sensitive myocyte death.	Zinc	148-150	tumor protein p53	Homo sapiens	26-29
21660051-5	2011	Silencing of GSK-3beta or p53 expression was cardioprotective, indicating that activation of the ERK-GSK-3beta-p53 signaling pathway is involved in Zn(2+)-sensitive myocyte death.	Zinc	148-150	mitogen-activated protein kinase 1	Homo sapiens	97-100
21660051-5	2011	Silencing of GSK-3beta or p53 expression was cardioprotective, indicating that activation of the ERK-GSK-3beta-p53 signaling pathway is involved in Zn(2+)-sensitive myocyte death.	Zinc	148-150	tumor protein p53	Homo sapiens	111-114
21757718-1	2011	Histidine-rich glycoprotein (HRG) is an abundant protein that binds fibrinogen and other plasma proteins in a Zn(2+)-dependent fashion but whose function is unclear.	Zinc	110-112	fibrinogen beta chain	Homo sapiens	68-78
21806983-12	2011	These results suggested that Zn-administration did not affect osteoblastogenesis but decreased osteoclastogenesis by inhibiting RANK expression through suppression of the production of reactive oxygen species and ERK activation in Zn-adequate rats.	Zinc	29-31	Eph receptor B1	Rattus norvegicus	213-216
21777051-6	2011	The results obtained suggest that Zn-induced augmentation of total SOD, SOD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in Zn-induced oxidative stress leading to dopaminergic neurodegeneration.	Zinc	34-36	superoxide dismutase 1	Rattus norvegicus	67-70
21777051-6	2011	The results obtained suggest that Zn-induced augmentation of total SOD, SOD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in Zn-induced oxidative stress leading to dopaminergic neurodegeneration.	Zinc	34-36	superoxide dismutase 1	Rattus norvegicus	72-76
21797865-5	2011	This activity is supported when Abeta:Zn aggregates are the source of extracellular Zn and adding PBT2 to Abeta:Zn preparations promotes Abeta degradation by matrix metalloprotease 2.	Zinc	38-40	amyloid beta precursor protein	Homo sapiens	32-37
21797865-8	2011	These data demonstrate PBT2 can decrease Abeta levels by sequestering the Zn that promotes extracellular formation of protease resistant Abeta:Zn aggregates, and that subsequent intracellular translocation of the Zn by PBT2 induces cellular responses with synapto-trophic potential.	Zinc	74-76	amyloid beta precursor protein	Homo sapiens	41-46
21797865-8	2011	These data demonstrate PBT2 can decrease Abeta levels by sequestering the Zn that promotes extracellular formation of protease resistant Abeta:Zn aggregates, and that subsequent intracellular translocation of the Zn by PBT2 induces cellular responses with synapto-trophic potential.	Zinc	74-76	amyloid beta precursor protein	Homo sapiens	137-142
21797865-8	2011	These data demonstrate PBT2 can decrease Abeta levels by sequestering the Zn that promotes extracellular formation of protease resistant Abeta:Zn aggregates, and that subsequent intracellular translocation of the Zn by PBT2 induces cellular responses with synapto-trophic potential.	Zinc	143-145	amyloid beta precursor protein	Homo sapiens	137-142
21797865-8	2011	These data demonstrate PBT2 can decrease Abeta levels by sequestering the Zn that promotes extracellular formation of protease resistant Abeta:Zn aggregates, and that subsequent intracellular translocation of the Zn by PBT2 induces cellular responses with synapto-trophic potential.	Zinc	143-145	amyloid beta precursor protein	Homo sapiens	137-142
21656670-7	2011	Zn- also decreased the medium and cell layer alkaline phosphatase ALP activity.	Zinc	0-2	alopecia, recessive	Mus musculus	66-69
21656670-8	2011	This decreased ALP activity might cause the decrease of Pi accumulation in response to Zn-, as measured by von Kossa staining.	Zinc	87-89	alopecia, recessive	Mus musculus	15-18
21866963-3	2011	The conjugation of the antithrombin or anti-ATP aptamers to CdSe/ZnS semiconductor quantum dots (QDs) allowed the detection of thrombin or ATP through the luminescence of the QDs that is powered by a chemiluminescence resonance energy-transfer (CRET) process stimulated by the hemin/G-quadruplex/thrombin complex or the hemin/G-quadruplex/ATP nanostructure, in the presence of luminol/H(2)O(2).	Zinc	65-68	coagulation factor II, thrombin	Homo sapiens	27-35
21866963-3	2011	The conjugation of the antithrombin or anti-ATP aptamers to CdSe/ZnS semiconductor quantum dots (QDs) allowed the detection of thrombin or ATP through the luminescence of the QDs that is powered by a chemiluminescence resonance energy-transfer (CRET) process stimulated by the hemin/G-quadruplex/thrombin complex or the hemin/G-quadruplex/ATP nanostructure, in the presence of luminol/H(2)O(2).	Zinc	65-68	coagulation factor II, thrombin	Homo sapiens	127-135
21861532-6	2011	Subsequent statistical adsorption experiments confirmed these screening results, with the adsorbent A-AAm-Dpa-Zn(2+) showing the highest adsorption capacity (426 mg/g) for CG-8, almost twice that of adsorbent A-AAm-DMAPAA.	Zinc	110-112	actin binding transcription modulator	Homo sapiens	172-176
21726901-3	2011	Cd induced an accumulation of Cd and Zn in parallel to depletion in important variables (GSH, GSH/GSSG, CuZn-SOD and GPx activities) and to elevation in others (Cd/Zn and GSSG).	Zinc	37-39	superoxide dismutase 1	Rattus norvegicus	104-112
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	148-152	amyloid beta precursor protein	Homo sapiens	125-130
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	148-152	amyloid beta precursor protein	Homo sapiens	125-130
21939532-6	2011	However, application of soluble Abeta prevented association of Zn2+ ions with ProSAP2/Shank3 in a cell-based assay and decreased the concentration of Zn2+ clusters within dendrites.	Zinc	63-67	amyloid beta precursor protein	Homo sapiens	32-37
21939532-6	2011	However, application of soluble Abeta prevented association of Zn2+ ions with ProSAP2/Shank3 in a cell-based assay and decreased the concentration of Zn2+ clusters within dendrites.	Zinc	150-154	amyloid beta precursor protein	Homo sapiens	32-37
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	126-131
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	49-53	amyloid beta precursor protein	Homo sapiens	38-43
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	49-53	amyloid beta precursor protein	Homo sapiens	126-131
21939532-9	2011	CONCLUSIONS: We conclude that sequestration of Zn2+ ions by Abeta significantly contributes to changes in ProSAP2/Shank3 platforms.	Zinc	47-51	amyloid beta precursor protein	Homo sapiens	60-65
21889458-2	2011	Under in vitro physiological conditions, zinc (Zn(II)) can bind to Abeta and redirect its assembly from amyloid fibrillar toward less toxic amorphous aggregation.	Zinc	47-53	amyloid beta precursor protein	Homo sapiens	67-72
21757718-4	2011	By immunoassay, HRG-fibrinogen complexes were detected in Zn(2+)-supplemented human plasma, a finding consistent with a high affinity interaction.	Zinc	58-64	fibrinogen beta chain	Homo sapiens	20-30
21709927-0	2011	CdSe/ZnS quantum dot-Cytochrome c bioconjugates for selective intracellular O2 - sensing.	Zinc	5-8	cytochrome c, somatic	Homo sapiens	21-33
21621258-5	2011	Recent evidence suggests that TRPML1 is involved in Fe(2+), Ca(2+) and Zn(2+) transport across the lysosomal membrane, ascribing novel physiological roles to this ion channel, and perhaps to its relatives TRPML2 and TRPML3 and illuminating poorly understood aspects of lysosomal function.	Zinc	71-77	mucolipin TRP cation channel 1	Homo sapiens	30-36
21641698-7	2011	However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis.	Zinc	121-127	mitogen-activated protein kinase 1	Homo sapiens	66-69
20592101-8	2011	In addition, CRP was positively associated with TBARS and carbonyl levels, but was significantly inversely associated with Zn and Se levels.	Zinc	123-125	C-reactive protein	Homo sapiens	13-16
20592101-9	2011	Positive correlations were found between T lymphocyte CD3 and CD4 percentages and Zn, Se, and Fe levels.	Zinc	82-84	CD4 molecule	Homo sapiens	62-65
21709927-1	2011	We demonstrate that the coupling system of negatively capped CdSe/ZnS QDs with an oxidized Cytochrome c (Cyt c) is capable of the fluorescent imaging of a superoxide radical (O(2) -) with high sensitivity and specificity in living cells, without interference from other Reactive Oxygen Species (ROS) or relevant intracellular components.	Zinc	66-69	cytochrome c, somatic	Homo sapiens	91-103
21709927-1	2011	We demonstrate that the coupling system of negatively capped CdSe/ZnS QDs with an oxidized Cytochrome c (Cyt c) is capable of the fluorescent imaging of a superoxide radical (O(2) -) with high sensitivity and specificity in living cells, without interference from other Reactive Oxygen Species (ROS) or relevant intracellular components.	Zinc	66-69	cytochrome c, somatic	Homo sapiens	105-110
21614444-3	2011	Treatments with Zn(CH(3)COO)(2) (50-350 muM) induced a dose-dependent ICAM-1 expression.	Zinc	16-18	latexin	Homo sapiens	40-43
20721639-10	2011	In the marginally Zn-deficient dams, femoral Zn content, serum concentrations of Zn, and osteocalcin were reduced when compared with control dams.	Zinc	18-20	bone gamma-carboxyglutamate protein	Rattus norvegicus	89-100
21653577-6	2011	However, dietary Zn and heme iron were positively associated with CRP [mean: 1.73, 1.75, 1.78, 1.88, and 1.96 mg/L across increasing quintiles of Zn and 1.72, 1.76, 1.83, 1.86, and 1.94 mg/L across increasing quintiles of heme iron (P-trend = 0.002 and 0.01, respectively).	Zinc	17-19	C-reactive protein	Homo sapiens	66-69
21600978-3	2011	In this paper, we tested the hypothesis that oxidative stress is involved in Zn deficiency-induced altered tubulin dynamics and the associated dysregulation of transcription factor NF-kappaB.	Zinc	77-79	nuclear factor kappa B subunit 1	Homo sapiens	181-190
22103109-5	2011	The specific saturation magnetization (Msh) of 63.2 Am2/kg for the SrFe12O19/Ni(0.5)Zn(0.5)Fe2O4 composite ferrite nanofibers obtained at 900 degrees C for 2 hours locates between that for the single SrFe12O19 ferrite (48.5 Am2/kg) and the single Ni(0.5)Zn(0.5)Fe2O4 ferrite (69.3 Am2/kg).	Zinc	84-86	msh homeobox 2	Homo sapiens	39-42
21680532-5	2011	We demonstrate that the Zn-binding domain of N(pro) is essential for the interaction of N(pro) with IRF7.	Zinc	24-26	interferon regulatory factor 7	Homo sapiens	100-104
21600978-7	2011	Consistent with the above, Zn deficiency-induced tubulin-mediated alterations in transcription factor NF-kappaB nuclear translocation were prevented by treating IMR-32 cells with LA and NAC.	Zinc	27-29	nuclear factor kappa B subunit 1	Homo sapiens	102-111
21600978-8	2011	Binding of the NF-kappaB protein p50, dynein, and karyopherin alpha (components of the NF-kappaB transport complex) to beta-tubulin as well as the expression of NF-kappaB-dependent genes (Bcl-2, cyclin D1, and c-myc) was also restored by the addition of LA and NAC to Zn-deficient cells.	Zinc	268-270	nuclear factor kappa B subunit 1	Homo sapiens	15-24
21600978-9	2011	In conclusion, a deficit in Zn viability could affect early brain development through: (1) an induction of oxidative stress, (2) tubulin oxidation, (3) altered tubulin dynamics, and (4) deregulation of signals (e.g., NF-kappaB) involved in critical developmental events.	Zinc	28-30	nuclear factor kappa B subunit 1	Homo sapiens	217-226
21640589-2	2011	This work elucidates the modes and molecular mechanisms of the interaction of IPA, FP and GKP with ACE, including mechanisms that bind the peptides to the cofactor Zn(2+).	Zinc	164-166	angiotensin I converting enzyme	Homo sapiens	99-102
21521659-4	2011	Superimposing an alginate sol with Cu(2+), Sr(2+), or Zn(2+) ion containing solutions allowed the creation of hydrogels with capillaries 18, 25 and 55 mum in diameter, respectively.	Zinc	54-60	latexin	Homo sapiens	151-154
21614400-2	2011	5-(Pyren-1-yl)-4,6-dipyrrin (PYDPY1) was synthesized and exhibited high selectivity and sensitivity to Zn(II) (K(d) of 20 muM) compared to other metal ions.	Zinc	103-105	latexin	Homo sapiens	122-125
21630714-1	2011	The low-frequency vibrational coherence from Zn(II)-substituted cytochrome c (ZnCytc) was characterized at room temperature in the native and acid/high-salt molten-globule states using femtosecond pump-probe, dynamic-absorption spectroscopy and impulsive excitation of the Soret absorption band.	Zinc	45-51	cytochrome c, somatic	Homo sapiens	64-76
21640589-3	2011	It was observed that the best docking poses obtained for IPA, FP and GKP were at the ACE catalytic site with very similar modes of interaction, including the interaction with Zn(2+).	Zinc	175-177	angiotensin I converting enzyme	Homo sapiens	85-88
21640589-4	2011	The interactions, including H-bonds, hydrophobic, hydrophilic, and electrostatic interactions, as well as the interaction with Zn(2+), were responsible for the binding between the bioactive peptides and ACE.	Zinc	127-129	angiotensin I converting enzyme	Homo sapiens	203-206
21511895-8	2011	Supplementation with Zn and Se resulted in a significant decrease in MDA, elevation in GSH, GSH-Px, SOD and catalase levels.	Zinc	21-23	glutathione peroxidase 1	Rattus norvegicus	92-98
21511895-8	2011	Supplementation with Zn and Se resulted in a significant decrease in MDA, elevation in GSH, GSH-Px, SOD and catalase levels.	Zinc	21-23	catalase	Rattus norvegicus	108-116
21549128-6	2011	By measuring the rates of Cu and Zn release using an absorbance-based assay, dimer dissociation through chemical cross-linking, and beta-barrel conformation changes by tryptophan fluorescence, we established that wild-type SOD1 unfolds by a branched pathway involving a Zn-deficient monomer as the dominant intermediate of the major pathway, and with various metal-loaded and Cu-deficient dimers populated along the minor pathway.	Zinc	270-272	superoxide dismutase 1	Homo sapiens	223-227
21262064-4	2011	Aspartate aminotransferase and alanine aminotransferase levels were elevated in rats with OS coupled with the Zn- and NA-deficient diet, which decreased towards normal with excess dietary NA.	Zinc	110-112	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-26
21612223-4	2011	As the latter binding mode has been recently invoked to explain the redox activity of the copper-Abeta complex, the formation of ternary metal complexes may justify the recently proposed protective role of zinc(II) in Alzheimer"s disease.	Zinc	206-214	amyloid beta precursor protein	Homo sapiens	97-102
21612223-5	2011	Therefore, the reported results suggest that zinc(II) competes with copper for Abeta binding and inhibits copper-mediated Abeta redox chemistry.	Zinc	45-53	amyloid beta precursor protein	Homo sapiens	79-84
21612223-5	2011	Therefore, the reported results suggest that zinc(II) competes with copper for Abeta binding and inhibits copper-mediated Abeta redox chemistry.	Zinc	45-53	amyloid beta precursor protein	Homo sapiens	122-127
21626587-3	2011	Insulin binds Zn(II) to form a hexamer, which is important for its storage in vivo and in drug formulations.	Zinc	14-20	insulin	Homo sapiens	0-7
21660117-2	2011	The platform is based on a new bimetallic Hg-Bi/single-walled carbon nanotubes (SWNTs) composite modified glassy carbon electrode (GCE), demonstrating remarkably improved performance for the anodic stripping assay of Zn(II), Cd(II) and Pb(II).	Zinc	217-223	submaxillary gland androgen regulated protein 3B	Homo sapiens	236-242
21310461-8	2011	Analar-PPT and PPT-Ind biodegradation was further reduced by low salinity, high DOM and dissolved Zn and Pb (6.3x10(-4)h(-1), 1100 ht(1/2) for Analar-PPT; 7.5x10(-4)h(-1), 924 ht(1/2) for PPT-Ind).	Zinc	98-100	tachykinin precursor 1	Homo sapiens	7-10
21847962-5	2011	The relative selectivity coefficient of Pb(II)-IIPs for Pb(II) was 6.25, 6.18, 6.25 and 6.38 in the presence of Cd(II), Cu(II), Mn(II) and Zn(II) interferences, respectively.	Zinc	139-141	submaxillary gland androgen regulated protein 3B	Homo sapiens	40-46
21847962-5	2011	The relative selectivity coefficient of Pb(II)-IIPs for Pb(II) was 6.25, 6.18, 6.25 and 6.38 in the presence of Cd(II), Cu(II), Mn(II) and Zn(II) interferences, respectively.	Zinc	139-141	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
21056589-7	2011	In the WT near-pure neuronal cultures, a brief exposure to sublethal concentrations of Zn2+-enhanced NMDA receptor-mediated cell death, an effect that was far more pronounced in the SOD1(G93A) cultures.	Zinc	87-91	superoxide dismutase 1, soluble	Mus musculus	182-186
21549603-7	2011	The compensatory effects of removing gtl-2 are counterbalanced by another TRPM channel, GTL-1, and can be recapitulated by acute treatment with divalent cation chelators, including those specific for Zn(2+).	Zinc	200-202	Gon-Two Like (TRP subfamily)	Caenorhabditis elegans	37-42
20950652-2	2011	Zn(2+) binding to S100B increases its affinity towards Ca(2+) as well as towards target peptides and proteins.	Zinc	0-6	S100 calcium binding protein B	Homo sapiens	18-23
20950652-3	2011	Cu(2+) and Zn(2+) bind presumably to the same site in S100B.	Zinc	11-17	S100 calcium binding protein B	Homo sapiens	54-59
20950652-4	2011	We determined the structures of human Zn(2+)- and Ca(2+)-loaded S100B at pH 6.5, pH 9, and pH 10 by X-ray crystallography at 1.5, 1.4, and 1.65A resolution, respectively.	Zinc	38-44	S100 calcium binding protein B	Homo sapiens	64-69
20950652-10	2011	We observed that in Zn(2+)-Ca(2+)-loaded S100B the C-termini of helix IV adopt a distinct conformation.	Zinc	20-26	S100 calcium binding protein B	Homo sapiens	41-46
21525261-6	2011	In a culture experiment using isolated mesenteric leukocytes, TNFalpha production was higher (P &lt; 0.05) and TNF receptor type I (TNFR1) expression was detected in culture medium containing 20 and 30 mumol/L of Zn compared with culture medium lacking Zn supplementation.	Zinc	213-215	tumor necrosis factor	Rattus norvegicus	62-70
21187142-4	2011	A slow time course of the EDTA-induced band-shift suggested removal of a pre-bound metal ion (Me(++)) with affinity of ~0.1 nM, which was similar to the previously determined affinity of PDE5 for Zn(++).	Zinc	196-202	phosphodiesterase 5A	Homo sapiens	187-191
21310461-8	2011	Analar-PPT and PPT-Ind biodegradation was further reduced by low salinity, high DOM and dissolved Zn and Pb (6.3x10(-4)h(-1), 1100 ht(1/2) for Analar-PPT; 7.5x10(-4)h(-1), 924 ht(1/2) for PPT-Ind).	Zinc	98-100	tachykinin precursor 1	Homo sapiens	15-18
21310461-8	2011	Analar-PPT and PPT-Ind biodegradation was further reduced by low salinity, high DOM and dissolved Zn and Pb (6.3x10(-4)h(-1), 1100 ht(1/2) for Analar-PPT; 7.5x10(-4)h(-1), 924 ht(1/2) for PPT-Ind).	Zinc	98-100	tachykinin precursor 1	Homo sapiens	15-18
21310461-8	2011	Analar-PPT and PPT-Ind biodegradation was further reduced by low salinity, high DOM and dissolved Zn and Pb (6.3x10(-4)h(-1), 1100 ht(1/2) for Analar-PPT; 7.5x10(-4)h(-1), 924 ht(1/2) for PPT-Ind).	Zinc	98-100	tachykinin precursor 1	Homo sapiens	15-22
21780454-0	2011	Identification of p53 gene by using CdSe/ZnS conjugation and hybridization.	Zinc	41-44	tumor protein p53	Homo sapiens	18-21
21345721-7	2011	In addition, the effect of some metal ions Cu(2+), Ca(2+), Mg(2+), and Zn(2+) on the binding constant between SAS and BSA was examined.	Zinc	71-73	albumin	Homo sapiens	118-121
21430246-10	2011	However, Zn supplementation of D dams decreased hepcidin expression in their offspring (P &lt; 0.0001).	Zinc	9-11	hepcidin antimicrobial peptide	Rattus norvegicus	48-56
21239534-4	2011	A contributory role of decreases in [Zn](i) in LPS-induced apoptosis (as determined by caspase-3/7 activation, annexin-V binding, and cytochrome c release) in SPAECs was revealed by mimicking the effect of LPS with the zinc chelator, TPEN, and inhibiting LPS- (or TPEN)-induced apoptosis with exogenous zinc.	Zinc	37-39	LOC101107954	Ovis aries	134-146
21171943-2	2011	The structures of Sr(2+) and Ni(2+) complexes are similar to Zn(2+) insulin and are in T6 conformation.	Zinc	61-63	insulin	Homo sapiens	68-75
21425789-9	2011	The mixed Mn-Zn hetero-dimetallic clusters appear to be also able to perform the hydrolysis of the Pro-Gly substrate, with a slight preference for the Mn1-Zn2 configuration.	Zinc	155-158	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	151-154
21348480-10	2011	We show that IRAP has a second Zn(2+) binding site, not associated with the catalytic region, which is lost upon binding Ang IV.	Zinc	31-33	leucyl and cystinyl aminopeptidase	Homo sapiens	13-17
21393238-7	2011	The role of Cu,Zn-SOD was biologically relevant in that Cu,Zn-SOD(-/-) mice generated significantly less H(2)O(2) and had less oxidant stress in bronchoalveolar lavage fluid and lung parenchyma.	Zinc	15-17	superoxide dismutase 1	Homo sapiens	18-21
20638923-5	2011	Similarly, compared with the carriers of GSTM1 power with a lower serum Zn, Se or Cr(3+), the OR of the carriers of GSTM1 null with a higher serum Zn, Se and Cr(3+) was separately 0.16, 0.07 and 0.26, highlighting the protection against NSCLC.	Zinc	72-74	glutathione S-transferase mu 1	Homo sapiens	41-46
20638923-5	2011	Similarly, compared with the carriers of GSTM1 power with a lower serum Zn, Se or Cr(3+), the OR of the carriers of GSTM1 null with a higher serum Zn, Se and Cr(3+) was separately 0.16, 0.07 and 0.26, highlighting the protection against NSCLC.	Zinc	72-74	glutathione S-transferase mu 1	Homo sapiens	116-121
20638923-5	2011	Similarly, compared with the carriers of GSTM1 power with a lower serum Zn, Se or Cr(3+), the OR of the carriers of GSTM1 null with a higher serum Zn, Se and Cr(3+) was separately 0.16, 0.07 and 0.26, highlighting the protection against NSCLC.	Zinc	147-149	glutathione S-transferase mu 1	Homo sapiens	116-121
20638923-6	2011	CONCLUSIONS: Our findings suggested that CYP1A1 or GSTM1 variants may significantly modify the associations between level of serum trace metals (Cu, Zn, Se or Cr) and NSCLC, indicating the intriguing pathogenesis of lung cancer.	Zinc	149-151	glutathione S-transferase mu 1	Homo sapiens	51-56
21245412-9	2011	Immunohistochemical analysis of carcinomas showed that Zn supplementation caused a shift to a less proliferative/aggressive cancer phenotype by reducing cell proliferation, stimulating apoptosis and decreasing expression of the key tumor markers cyclin D1, p53 and COX-2.	Zinc	55-57	cyclin D1	Rattus norvegicus	246-255
21167956-10	2011	Exposure of trout to Zn resulted in a decrease in expression of IGF-II starting from 6h whereas the significant decrease started at 6h in cobalt exposure and this decrease elevated at 24h.	Zinc	21-23	insulin-like growth factor II	Oncorhynchus mykiss	64-70
21219335-5	2011	In A. thaliana, lowering the expression of IRT1 and IRT2 through the addition of excess Fe to the medium increases Zn tolerance.	Zinc	115-117	iron regulated transporter 2	Arabidopsis thaliana	52-56
24250344-1	2011	Lysozyme, as a model protein, was precipitated through the formation of protein-Zn complex to micronize for subsequent encapsulation within poly (lactic-co-glycolic acid) (PLGA) microspheres.	Zinc	80-82	lysozyme	Homo sapiens	0-8
21448202-13	2011	Conversely, the Zn compounds were least inhibitory toward HO-2.	Zinc	16-18	heme oxygenase 2	Rattus norvegicus	58-62
21216965-6	2011	Our results show that Al(3+) and Zn(2+), but not Cu(2+) and Fe(3+), induce larger hydrophobic exposures of Abeta conformation, resulting in its significant destabilization at the early stage.	Zinc	33-35	amyloid beta precursor protein	Homo sapiens	107-112
21847988-7	2011	AtCAX3 is the mainly Ca2+/H+ transporter in response to salt stress; AtCAX2 and AtCAX4 participate in transportation and detoxicification of heavy metal ions (Cd2+, Zn2+, and Mn2+) in cells under heavy metal stress, and impact root/shoot Cd partitioning in plant.	Zinc	165-169	cation exchanger 3	Arabidopsis thaliana	0-6
21394800-4	2011	Computational analyses show that Zn(2+) and Cu(2+) form pentacoordinate complexes involving both the His4 and His8 residues of the N-terminal domain of one monomeric unit and the His84 and Asp105 residues of the other monomeric unit of the NGF active dimer.	Zinc	33-35	nerve growth factor	Homo sapiens	240-243
21216965-8	2011	Cu(2+) and Zn(2+) induce similar assembly of transiently appearing Abeta oligomers at the early state.	Zinc	11-17	amyloid beta precursor protein	Homo sapiens	67-72
21216965-11	2011	In conclusion, Zn(2+), Cu(2+), Fe(3+), and Al(3+) adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.	Zinc	15-21	amyloid beta precursor protein	Homo sapiens	110-115
21216965-11	2011	In conclusion, Zn(2+), Cu(2+), Fe(3+), and Al(3+) adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.	Zinc	15-21	amyloid beta precursor protein	Homo sapiens	123-128
21269544-7	2011	Micromolar Zn(2+) and Cu(2+) inhibited the disk ADPR-cyclase activity (half maximal inhibitory concentration, IC50=1.1 and 3.6 muM, respectively).	Zinc	11-13	latexin	Homo sapiens	127-130
21248196-5	2011	Data suggest Zip5 imports Zn into Sertoli cells and spermatocytes, augmented by Zip10 (primary spermatocytes) and Zip8 (secondary spermatocytes).	Zinc	26-28	solute carrier family 39 (metal ion transporter), member 5	Mus musculus	13-17
21097531-6	2011	Zn supplementation reduced tumor burdens by 28% (wild-type) to 42% (Fhit-/-Nit1-/-).	Zinc	0-2	fragile histidine triad gene	Mus musculus	68-72
21359283-3	2011	There is increasing evidence demonstrating that the biometals zinc(ii) and copper(ii) interact with Abeta peptides and have an influence on their fibrillization and toxicity.	Zinc	62-70	amyloid beta precursor protein	Homo sapiens	100-105
21241850-8	2011	Under optimal conditions, a good linear relationship between the fluorescence response and concentration of Zn(2+) (or Cd(2+)) could be obtained in the range from 1.6 to 35 muM (1.3-25 muM for Cd(2+)).	Zinc	108-114	latexin	Homo sapiens	173-176
21241850-8	2011	Under optimal conditions, a good linear relationship between the fluorescence response and concentration of Zn(2+) (or Cd(2+)) could be obtained in the range from 1.6 to 35 muM (1.3-25 muM for Cd(2+)).	Zinc	108-114	latexin	Homo sapiens	185-188
21241850-9	2011	The limit of detection (LOD) for Zn(2+) and Cd(2+) were found to be 1.2 and 0.5 muM, respectively.	Zinc	33-35	latexin	Homo sapiens	80-83
21098024-2	2011	Notably, aSMase exists in two forms: a zinc (Zn(2+))-independent lysosomal aSMase (L-SMase) and a Zn(2+)-dependent secreted aSMase (S-SMase) that arise from alternative trafficking of a single protein precursor.	Zinc	45-52	sphingomyelin phosphodiesterase 1	Homo sapiens	9-15
21098024-8	2011	Moreover, V5-aSMase possessed Zn(2+)-dependent activity suggesting it may represent the common protein precursor of S-SMase and L-SMase.	Zinc	30-32	sphingomyelin phosphodiesterase 1	Homo sapiens	13-19
20927436-11	2011	These novel insulin mimetics functioned at a markedly lower concentration than two widely studied insulin mimetics, zinc(ii) complexes and vanadium compounds, and also showed novel, beneficial effects on endothelial cell function (a key determinant of secondary complications in diabetes).	Zinc	116-124	insulin	Homo sapiens	12-19
21217644-5	2011	Furthermore, depletion of synaptic Zn(2+) along with the knockdown of zinc-insensitive Shank1 causes the rapid disintegration of PSDs and the loss of several postsynaptic molecules including Homer1, PSD-95 and NMDA receptors.	Zinc	35-37	homer scaffold protein 1	Homo sapiens	191-197
21268155-4	2011	The dissociation constants for Ca(2+) and Zn(2+) binding were sensitive to the presence of added bicarbonate, and were 450 muM (Ca(2+)) and 200 muM (Zn(2+)) in serum.	Zinc	42-48	latexin	Homo sapiens	123-126
21268155-4	2011	The dissociation constants for Ca(2+) and Zn(2+) binding were sensitive to the presence of added bicarbonate, and were 450 muM (Ca(2+)) and 200 muM (Zn(2+)) in serum.	Zinc	42-48	latexin	Homo sapiens	144-147
21268155-4	2011	The dissociation constants for Ca(2+) and Zn(2+) binding were sensitive to the presence of added bicarbonate, and were 450 muM (Ca(2+)) and 200 muM (Zn(2+)) in serum.	Zinc	149-155	latexin	Homo sapiens	123-126
21268155-4	2011	The dissociation constants for Ca(2+) and Zn(2+) binding were sensitive to the presence of added bicarbonate, and were 450 muM (Ca(2+)) and 200 muM (Zn(2+)) in serum.	Zinc	149-155	latexin	Homo sapiens	144-147
20972690-0	2011	Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes.	Zinc	129-137	thymoma viral proto-oncogene 1	Mus musculus	40-43
20972690-3	2011	In this context, a highly diverse library of 11 new zinc(II) complexes with phenolic, picolinic, pyridino, and hydroxamic ligands, all containing features beneficial for medicinal purposes, was prepared and screened in an assay that detected levels of phospho-Akt in lysates from NIH3T3 cells after treatment with the compounds.	Zinc	52-60	thymoma viral proto-oncogene 1	Mus musculus	260-263
21123176-9	2011	A His-248/His-250 Zn(2+)-mediated intermolecular bridge was observed in a catalytic domain crystal structure (Protein Data Bank code 3IR2); however, atomic force microscopy analyses showed that the stoichiometry of the A3G-ssDNA complexes changed insignificantly when these residues were mutated to Ala.	Zinc	18-20	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	219-222
21076775-1	2011	Zn(2+) in the tumor-suppressor protein p53 DNA-binding domain (DBD) is essential for its structural stability and DNA-binding specificity.	Zinc	0-2	tumor protein p53	Homo sapiens	39-42
21142220-0	2011	An insight to conserved water molecular dynamics of catalytic and structural Zn(+2) ions in matrix metalloproteinase 13 of human.	Zinc	77-79	matrix metallopeptidase 13	Homo sapiens	92-119
21142220-6	2011	So the hydrophilic topology and stereochemistry of water mediated coupling between Zn-ions may provide some plausible hope towards the design of some bidentate/polydentate bridging ligands or inhibitors for MMP-13.	Zinc	83-85	matrix metallopeptidase 13	Homo sapiens	207-213
20672323-11	2011	Inhibitor studies indicated that the galectin-3 cleavage activity in seminal plasma is a Zn(2+) sensitive, serine protease.	Zinc	89-95	coagulation factor II, thrombin	Homo sapiens	107-122
21076775-8	2011	The simulation results of the Mg(2+) system and the native Zn(2+) system show that the binding affinity of Mg(2+)to the p53DBD is weaker than that of Zn(2+), in agreement with the DFT calculation results and experiments.	Zinc	59-61	tumor protein p53	Homo sapiens	120-123
21035435-5	2011	LL-37 secretion increased immediately (1h) after exposure to 20muM Zn (0.29+-0.04ng/mL), which continued up to 48h of exposure (0.58+-0.05ng/mL).	Zinc	67-69	cathelicidin antimicrobial peptide	Homo sapiens	0-5
21804240-7	2011	Peptides from the middle region of hPrP showed a high affinity for Cu2+, but binding to Zn2+, Ni2+, and Co2+ was dependent on peptide length.	Zinc	88-92	prion protein	Homo sapiens	35-39
21804240-9	2011	Interestingly, hPrP193-230, which contained no H residues, also bound to Cu2+, Zn2+, Ni2+, and Co2+, indicating that this region is a novel metal-binding site in the C-terminal region of PrP(C).	Zinc	79-83	prion protein	Homo sapiens	15-19
21121690-0	2011	Synthesis, crystal structure, and electron paramagnetic resonance investigations of heteronuclear Co(II)/Zn(II) and Co(II)/Cd(II) coordination polymers.	Zinc	105-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-104
21121690-3	2011	In order to obtain heteronuclear compounds, we synthesized Co(II)-substituted Zn(II) and Cd(II) coordination polymers.	Zinc	78-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
21121690-4	2011	At T = 5 K, the powder samples of the diamagnetically diluted Co(II)/Zn(II) and Co(II)/Cd(II) systems [Co/(Zn,Cd)   0.01] show intense electron paramagnetic resonance spectra, which were analyzed with an effective spin of S" = 1/2.	Zinc	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
21629666-4	2011	We find that although VPS29 can coordinate metal ions Mn(2+) and Zn(2+) in both the putative active site and at other locations, the affinity for metals is low, and lack of activity in phosphatase assays using a putative peptide substrate support the conclusion that VPS29 is not a functional metalloenzyme.	Zinc	65-67	VPS29 retromer complex component	Homo sapiens	22-27
22163032-5	2011	When Ca(2+) mobilization is induced by BzATP, a P2X(7) agonist, it is attenuated in the presence of extracellular Mg(2+) or Zn(2+), negligible in the absence of extracellular Ca(2+), and inhibited by the competitive P2X7 receptor inhibitor, A438079.	Zinc	124-126	purinergic receptor P2X 7	Homo sapiens	48-54
20524045-4	2010	Chelation of Zn(2+) with N,N,N",N"-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) blocked the increase in phospho-Erk and LC3-II levels, and attenuated AV formation and cell death.	Zinc	13-15	mitogen-activated protein kinase 1	Homo sapiens	117-120
21042644-0	2010	Photophysical properties of Zn-substituted cytochrome c investigated by single-molecule and ensemble-averaged spectroscopy.	Zinc	28-30	cytochrome c, somatic	Homo sapiens	43-55
20696204-4	2010	The purified alpha-mannosidase activity depends on a single Zn(2+) ion per subunit is inhibited by swainsonine with an IC(50) of 0.2 mM.	Zinc	60-62	SDR family oxidoreductase	Saccharolobus solfataricus	13-30
22247668-4	2011	The detection principle is demonstrated with a time-resolved fluorescence immunoassay for the detection of C-reactive protein (CRP) using CdSe-ZnS nanoparticles and green light excitation.	Zinc	143-146	C-reactive protein	Homo sapiens	107-125
22247668-4	2011	The detection principle is demonstrated with a time-resolved fluorescence immunoassay for the detection of C-reactive protein (CRP) using CdSe-ZnS nanoparticles and green light excitation.	Zinc	143-146	C-reactive protein	Homo sapiens	127-130
21197068-2	2010	It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Abeta plaques of the diseased brain can bind to Abeta and be linked to aggregation and neurotoxicity.	Zinc	152-158	amyloid beta precursor protein	Homo sapiens	169-174
21197068-2	2010	It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Abeta plaques of the diseased brain can bind to Abeta and be linked to aggregation and neurotoxicity.	Zinc	152-158	amyloid beta precursor protein	Homo sapiens	217-222
20524045-5	2010	Conversely, the addition of ZnCl(2) markedly potentiated tamoxifen-induced extracellular signal-regulated kinase (Erk) activation, autophagy and cell death, indicating that Zn(2+) has an important role in these events.	Zinc	28-30	mitogen-activated protein kinase 1	Homo sapiens	75-112
20524045-5	2010	Conversely, the addition of ZnCl(2) markedly potentiated tamoxifen-induced extracellular signal-regulated kinase (Erk) activation, autophagy and cell death, indicating that Zn(2+) has an important role in these events.	Zinc	28-30	mitogen-activated protein kinase 1	Homo sapiens	114-117
20951053-5	2010	The data from the single metal solution tests show that at pH 6.0 the affinity of the metal ions towards the PGAM(1) matrix follows the order: Cr(III)&gt;Cu(II) Pb(II)&gt;&gt;Zn(II) Cd(II).	Zinc	175-181	submaxillary gland androgen regulated protein 3B	Homo sapiens	161-167
20855510-2	2010	The Znu ABC transporter is essential for zinc (Zn) uptake and virulence in a number of bacterial pathogens.	Zinc	4-6	ABC transporter	Yersinia pestis	8-23
20660165-5	2010	Both in the absence of extracellular Ca(2+) and in the presence of Cd(2+) or Zn(2+), the SLURP-1-dependent elevation of NF-kappaB was almost completely blocked by inhibiting MEK1 activity.	Zinc	77-79	nuclear factor kappa B subunit 1	Homo sapiens	120-129
20956331-4	2010	By combining molecular modeling with phylogenetic, chemical, and functional analyses, we show that Keap1 directly recognizes NO, Zn(2+), and alkenals through three distinct sensors.	Zinc	129-131	kelch like ECH associated protein 1	Homo sapiens	99-104
20956331-9	2010	Taken together, our data suggest that Keap1 is a specialized sensor that quantifies stress by monitoring the intracellular concentrations of NO, Zn(2+), and alkenals, which collectively serve as second messengers that may signify danger and/or damage.	Zinc	145-151	kelch like ECH associated protein 1	Homo sapiens	38-43
21038913-3	2010	Hydrophobic electron donors and acceptors were encapsulated within the hemicarcerand, and photoinduced electron transfer (ET) between the Zn-substituted cytochrome c (MW = 12.3 kD) and the host-guest complexes (MW = 2.2 kD) was used to probe the association between the negatively charged hemicarceplex and the positively charged protein.	Zinc	138-140	cytochrome c, somatic	Homo sapiens	153-165
22778810-3	2010	The identified lead, HLA20A, exhibits little affinity for metal (Fe, Cu, and Zn) ions but can be activated following inhibition of AChE to liberate an active chelator, HLA20.	Zinc	77-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
20850960-0	2010	CdSe/ZnS quantum dots based electrochemical immunoassay for the detection of phosphorylated bovine serum albumin.	Zinc	5-8	albumin	Homo sapiens	99-112
20833102-0	2010	Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti-tubercular activity evaluation.	Zinc	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
20359724-5	2010	The alanine aminotransferase and aspartate aminotransferase levels were elevated in rats with OS and Zn-deficient diet, which were restored to normal levels with excess dietary Zn.	Zinc	101-103	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	33-59
20359724-5	2010	The alanine aminotransferase and aspartate aminotransferase levels were elevated in rats with OS and Zn-deficient diet, which were restored to normal levels with excess dietary Zn.	Zinc	177-179	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	33-59
20942746-1	2010	IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Abeta)-mediated oxidative damage, and acts as catalyst for Abeta aggregation in Alzheimer"s disease (AD).	Zinc	51-53	amyloid beta precursor protein	Homo sapiens	112-124
20942746-1	2010	IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Abeta)-mediated oxidative damage, and acts as catalyst for Abeta aggregation in Alzheimer"s disease (AD).	Zinc	51-53	amyloid beta precursor protein	Homo sapiens	126-131
20833102-1	2010	Co(II), Ni(II), Cu(II) and Zn(II) complexes with a new heterocyclic Schiff base derived by the condensation of isonicotinoylhydrazide and 3-acetylcoumarin have been synthesized.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
20815365-0	2010	Structural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5.	Zinc	62-68	histatin 3	Homo sapiens	114-124
21588900-1	2010	In the crystal structure of the zinc(II) complex of bicine, [Zn(C(6)H(12)NO(4))(2)], the deprotonated amino acid O,N,O"-chelates to the metal atom through a carboxyl-ate O atom, a hy-droxy O atom and the N atom, the three atoms occupying fac positions of the distorted octa-hedron surrounding the metal atom.	Zinc	32-40	FA complementation group C	Homo sapiens	238-241
20600713-6	2010	Like Zn(2+), Cd(2+) inhibits phosphatases, and hereby dephosphorylation of mitogen activated protein kinases (MAPK).	Zinc	5-11	mitogen-activated protein kinase 3	Homo sapiens	110-114
20733979-13	2010	For example, at the 10 ppb level, all of the Zn-IRMOFs are able to distinguish between TNT and the structurally similar xylenes.	Zinc	45-47	chromosome 16 open reading frame 82	Homo sapiens	87-90
20726777-1	2010	Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1.	Zinc	173-175	War1p	Saccharomyces cerevisiae S288C	222-226
20238111-8	2010	The molecular assay showed a decreasing trend of MT-1 relative gene expression levels in animals supplemented with Zn (6.87-fold), Se (3.58-fold), and their combination (1.69-fold) when compared to Cd-treated animals (16.22-fold).	Zinc	115-117	metallothionein 1	Rattus norvegicus	49-53
20852107-6	2010	The absorption percentages of Zn as Zn Gly chelate, Zn Met chelate, Zn AA C, Zn Pro B, and Zn Pro A in the duodenum and jejunum were 29 to 129% higher (P&lt;0.05) than those of Zn as ZnSO4, Zn+Gly, and Zn+Met in the following order: Zn Pro A&gt;Zn Pro B&gt;Zn AA C&gt;Zn Gly chelate or Zn Met chelate&gt;ZnSO4, Zn+Met, or Zn+Gly.	Zinc	30-32	PROA	Homo sapiens	236-241
20822138-2	2010	In this study, we show that the coordination of Zn(2+) to the ALS-associated enzyme Cu/Zn superoxide dismutase (SOD1) is directly controlled by the protein"s folding pathway.	Zinc	48-50	superoxide dismutase 1	Homo sapiens	84-110
20852107-11	2010	However, the reduction of Zn absorption as organic Zn sources was lessened with the increasing complex strengths, and the highest absorption of Zn as Zn Pro A was observed.	Zinc	26-28	PROA	Homo sapiens	153-158
20852107-11	2010	However, the reduction of Zn absorption as organic Zn sources was lessened with the increasing complex strengths, and the highest absorption of Zn as Zn Pro A was observed.	Zinc	51-53	PROA	Homo sapiens	153-158
20852107-11	2010	However, the reduction of Zn absorption as organic Zn sources was lessened with the increasing complex strengths, and the highest absorption of Zn as Zn Pro A was observed.	Zinc	51-53	PROA	Homo sapiens	153-158
20852107-11	2010	However, the reduction of Zn absorption as organic Zn sources was lessened with the increasing complex strengths, and the highest absorption of Zn as Zn Pro A was observed.	Zinc	51-53	PROA	Homo sapiens	153-158
20822138-2	2010	In this study, we show that the coordination of Zn(2+) to the ALS-associated enzyme Cu/Zn superoxide dismutase (SOD1) is directly controlled by the protein"s folding pathway.	Zinc	48-50	superoxide dismutase 1	Homo sapiens	112-116
20822138-3	2010	Zn(2+) first catalyzes the folding reaction by coordinating transiently to the Cu ligands of SOD1, which are all contained within the folding nucleus.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	93-97
20632994-0	2010	Zn(II) ions co-secreted with insulin suppress inherent amyloidogenic properties of monomeric insulin.	Zinc	0-6	insulin	Homo sapiens	93-100
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-93
20632994-2	2010	In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(6) hexamer, which assures osmotic stability of vesicles and prevents fibrillation of the peptide.	Zinc	67-73	insulin	Homo sapiens	27-34
20632994-2	2010	In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(6) hexamer, which assures osmotic stability of vesicles and prevents fibrillation of the peptide.	Zinc	67-73	insulin	Homo sapiens	96-103
20632994-2	2010	In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(6) hexamer, which assures osmotic stability of vesicles and prevents fibrillation of the peptide.	Zinc	67-69	insulin	Homo sapiens	27-34
20632994-2	2010	In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(6) hexamer, which assures osmotic stability of vesicles and prevents fibrillation of the peptide.	Zinc	67-69	insulin	Homo sapiens	96-103
20632994-4	2010	The effect of co-secreted Zn(II) ions on the fibrillation of monomeric insulin is unknown, however, it might prevent insulin fibrillation.	Zinc	26-32	insulin	Homo sapiens	71-78
20632994-5	2010	We showed that Zn(II) inhibits fibrillation of monomeric insulin at physiological pH values by forming a soluble Zn(II)-insulin complex.	Zinc	15-21	insulin	Homo sapiens	57-64
20632994-5	2010	We showed that Zn(II) inhibits fibrillation of monomeric insulin at physiological pH values by forming a soluble Zn(II)-insulin complex.	Zinc	15-21	insulin	Homo sapiens	120-127
20632994-5	2010	We showed that Zn(II) inhibits fibrillation of monomeric insulin at physiological pH values by forming a soluble Zn(II)-insulin complex.	Zinc	113-119	insulin	Homo sapiens	57-64
20632994-5	2010	We showed that Zn(II) inhibits fibrillation of monomeric insulin at physiological pH values by forming a soluble Zn(II)-insulin complex.	Zinc	113-119	insulin	Homo sapiens	120-127
20683528-0	2010	Electrogenerated chemiluminescence determination of C-reactive protein with carboxyl CdSe/ZnS core/shell quantum dots.	Zinc	90-93	C-reactive protein	Homo sapiens	52-70
20522546-6	2010	The signaling triggered by Zn(2+), via ZnR, or by ATP further activated MAP kinase and induced up-regulation of the sodium/proton exchanger NHE1 activity.	Zinc	27-29	solute carrier family 9 member A1	Homo sapiens	140-144
20681557-0	2010	Effects of DHLA-capped CdSe/ZnS quantum dots on the fibrillation of human serum albumin.	Zinc	28-31	albumin	Homo sapiens	74-87
20662514-11	2010	Mutation of the histidines that flank the CXXC motifs results in a zinc site structure that is similar to holo-WT-HypA at neutral pH (Zn(Cys)(4)) and is no longer responsive to nickel binding or pH changes.	Zinc	134-136	pre-mRNA processing factor 40 homolog A	Homo sapiens	114-118
20609366-3	2010	We have solved the crystal structure of LTA4H in complex with N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, a potent inhibitor of several Zn-metalloenzymes, both endopeptidases and aminopeptidases.	Zinc	158-160	leukotriene A4 hydrolase	Homo sapiens	40-45
20394811-3	2010	Cd-induced increase in Cd and Zn accumulation was accompanied by a decrease in important variables (GSH, GSH/GSSG, CuZn SOD and GPx activities) and by an increase in others (Cd/Zn, GSSG and CuZn SOD/GPx).	Zinc	30-32	superoxide dismutase 1	Rattus norvegicus	115-123
20660093-7	2010	These changes were normalized to those observed in ZN by treating ZS cells with Pifitherin, an inhibitor of p53 transactivation activity.	Zinc	51-53	tumor protein p53	Homo sapiens	108-111
20553223-6	2010	Zn and/or PQ exposure increased gene expression of DAT, CYP2E1, GSTA4-4, MT-I and MT-II, but reduced the expression of VMAT-2.	Zinc	0-2	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	56-62
20553223-6	2010	Zn and/or PQ exposure increased gene expression of DAT, CYP2E1, GSTA4-4, MT-I and MT-II, but reduced the expression of VMAT-2.	Zinc	0-2	metallothionein 1	Rattus norvegicus	73-77
20508080-1	2010	Genetic studies suggest that Zn transporters such as ZnT8 play a role in insulin secretion by pancreatic beta-cells; however, little is known about the dynamic roles of Zn trafficking pathways on beta-cell physiology.	Zinc	29-31	solute carrier family 30 (zinc transporter), member 8	Mus musculus	53-57
20508080-2	2010	To test the acute effects of the inflammatory cytokines interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNFalpha) on Zn homeostasis, the mRNA expression profile of Zn transporters of the ZnT and ZIP families was examined.	Zinc	132-134	interleukin 1 beta	Mus musculus	76-84
20508080-2	2010	To test the acute effects of the inflammatory cytokines interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNFalpha) on Zn homeostasis, the mRNA expression profile of Zn transporters of the ZnT and ZIP families was examined.	Zinc	132-134	tumor necrosis factor	Mus musculus	119-127
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	11-13	solute carrier family 30 (zinc transporter), member 8	Mus musculus	144-148
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	11-13	interleukin 1 beta	Mus musculus	162-170
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	74-76	solute carrier family 30 (zinc transporter), member 8	Mus musculus	144-148
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	74-76	interleukin 1 beta	Mus musculus	162-170
20603541-0	2010	Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein.	Zinc	22-25	alpha fetoprotein	Homo sapiens	126-143
20603541-1	2010	We report the imaging of hepatocellular carcinoma cells and the immunoassay for alpha fetoprotein (AFP) using CdTe/CdS/ZnS core-shell-shell QDs.	Zinc	119-122	alpha fetoprotein	Homo sapiens	80-97
20603541-1	2010	We report the imaging of hepatocellular carcinoma cells and the immunoassay for alpha fetoprotein (AFP) using CdTe/CdS/ZnS core-shell-shell QDs.	Zinc	119-122	alpha fetoprotein	Homo sapiens	99-102
20603541-4	2010	Furthermore, the thioglycolic acid (TGA)-capped CdTe/CdS/ZnS core-shell-shell QDs fluorescence lifetime is longer than fluorescein, so it was first engaged to conjugate with antigen for the determination of protein (AFP) by fluorescence polarization immunoassay.	Zinc	57-60	alpha fetoprotein	Homo sapiens	216-219
20843281-5	2010	The neutral zinc (II) complex 3 was also found to be considerably less toxic against Pgp-lacking cells compared to its cationic gallium(III) counterpart 4.	Zinc	12-21	ATP binding cassette subfamily B member 1	Homo sapiens	85-88
20843281-6	2010	Additionally, the neutral zinc(II) complex 3 demonstrated considerably more toxicity against Pgp expressing KB 8-5 cells (&gt; 10 microM) compared with its cationic counterpart 4 displaying minimal effect at highest concentration.	Zinc	26-34	ATP binding cassette subfamily B member 1	Homo sapiens	93-96
20394811-3	2010	Cd-induced increase in Cd and Zn accumulation was accompanied by a decrease in important variables (GSH, GSH/GSSG, CuZn SOD and GPx activities) and by an increase in others (Cd/Zn, GSSG and CuZn SOD/GPx).	Zinc	30-32	superoxide dismutase 1	Rattus norvegicus	190-198
20394811-4	2010	Zn supply intensified Cd retention and Cd/Zn; it amplified CuZn SOD activity, CuZn SOD/GPx and GSH/GSSG compared to normal values, but had no effect on Zn content increase.	Zinc	0-2	superoxide dismutase 1	Rattus norvegicus	59-67
20394811-4	2010	Zn supply intensified Cd retention and Cd/Zn; it amplified CuZn SOD activity, CuZn SOD/GPx and GSH/GSSG compared to normal values, but had no effect on Zn content increase.	Zinc	0-2	superoxide dismutase 1	Rattus norvegicus	78-86
20394811-7	2010	Zn concentration had positive correlation with CuZn SOD/GPx, and negative one with GPx activity, which reflects an indirect protective effect of Zn.	Zinc	0-2	superoxide dismutase 1	Rattus norvegicus	47-55
20413590-12	2010	Zn(2+) enhanced APC-mediated activation of protease activated receptor 1 and p44/42 MAPK.	Zinc	0-2	coagulation factor II thrombin receptor	Homo sapiens	43-72
20685471-7	2010	Compared with non-imprinted sorbent, the imprinted sorbent showed good imprinting effect for Ga(III) ion, the imprinting factor (alpha) was 2.6, the selectivity factor (beta) was 2.4 and 2.9 for Al(III) and Zn(II), respectively.	Zinc	207-209	l(2)46Cc	Drosophila melanogaster	93-100
20228268-3	2010	FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase 1/2 (ERK1/2; mitogen-activated protein kinase 44 [MAPK44] and MAPK42) and Akt (Ser473) phosphorylation in endothelial cells.	Zinc	26-28	thymoma viral proto-oncogene 1	Mus musculus	151-154
20466452-3	2010	The isotopic study revealed denitrification of the NO3-bearing groundwater that takes place through oxidation of the sulphide minerals associated with the gold deposit and leads to anomalous concentrations of some metals such as Zn, Co and Ni.	Zinc	229-231	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
20410362-9	2010	The current remaining showed decreased [Mg](o) affinities reminiscent of NR2C and NR2D subunits but was highly sensitive to [Zn](o), a potent NR2A blocker, showing a approximately 44.2 +/- 1.1% maximal inhibition at saturating concentrations with an IC(50) of 7.8 +/- 1.1 nM.	Zinc	125-127	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	Mus musculus	73-77
20481436-0	2010	Probing protein kinase (CK2) and alkaline phosphatase with CdSe/ZnS quantum dots.	Zinc	64-67	alkaline phosphatase, placental	Homo sapiens	33-53
20481436-5	2010	The hydrolytic activity of ALP is followed by the application of phosphotyrosine (4)-modified CdSe/ZnS QDs in the presence of tyrosinase as a secondary reporter biocatalyst.	Zinc	99-102	alkaline phosphatase, placental	Homo sapiens	27-30
20541508-8	2010	These data suggest the Zn may play a regulatory role for the cellular functions of fibronectin.	Zinc	23-25	fibronectin 1	Homo sapiens	83-94
19727574-6	2010	Here, we report the in vitro inhibitory effects of some metal ions, including Pb(+2), Cr(+2), Fe(+2), and Zn(+2), on the activity of human serum PON1 (hPON1; EC 3.1.8.1.).	Zinc	106-108	paraoxonase 1	Homo sapiens	145-149
19727574-6	2010	Here, we report the in vitro inhibitory effects of some metal ions, including Pb(+2), Cr(+2), Fe(+2), and Zn(+2), on the activity of human serum PON1 (hPON1; EC 3.1.8.1.).	Zinc	106-108	paraoxonase 1	Homo sapiens	151-156
23861627-1	2010	AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels.	Zinc	24-26	superoxide dismutase 1	Homo sapiens	27-30
20448202-1	2010	Although a key factor in Alzheimer"s disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive.	Zinc	71-73	amyloid beta precursor protein	Homo sapiens	166-171
20448202-1	2010	Although a key factor in Alzheimer"s disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive.	Zinc	159-161	amyloid beta precursor protein	Homo sapiens	166-171
20448202-3	2010	By covalently linking fragments (that have experiment-based coordinates) we observed that, in oligomeric Zn(2+)-Abeta(42), Zn(2+) can simultaneously coordinate intra- and intermolecularly, bridging two peptides.	Zinc	105-107	amyloid beta precursor protein	Homo sapiens	112-117
20448202-7	2010	Overall, Zn(2+) coordination promotes Abeta(42) aggregation leading to less uniform structures.	Zinc	9-15	amyloid beta precursor protein	Homo sapiens	38-43
20329713-2	2010	In this paper, we demonstrate that the beta domain of human metallothionein 1a, well-known to bind three Zn(2+) or Cd(2+) ions with nine cysteinyl sulfurs, is also capable of binding an additional Cd(2+) ion, leading to the formation of the supermetalated Cd(4)-beta-rhMT 1a.	Zinc	105-107	metallothionein 1A	Homo sapiens	60-78
20479680-8	2010	In F cells, zinc-regulated transporter (ZRT)/iron-regulated transporter (IRT)-like protein (Zip)4 expression was undetectable; Zn (50 micromol/L) increased levels of Zn transporter (ZnT)1, ZnT2, and metallothionein-1 mRNA and ZnT1 protein.	Zinc	127-129	solute carrier family 30 member 1	Homo sapiens	166-187
20479680-8	2010	In F cells, zinc-regulated transporter (ZRT)/iron-regulated transporter (IRT)-like protein (Zip)4 expression was undetectable; Zn (50 micromol/L) increased levels of Zn transporter (ZnT)1, ZnT2, and metallothionein-1 mRNA and ZnT1 protein.	Zinc	127-129	solute carrier family 30 member 1	Homo sapiens	226-230
23861627-1	2010	AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels.	Zinc	24-26	superoxide dismutase 1	Homo sapiens	32-52
20734839-3	2010	There was a negative correlation between the level of Zn++ and that of C-reactive protein (CRP) and a positive correlation between the former and the magnitude of a reduction in transferrin (TF) as a marker of protein-energy malnutrition.	Zinc	54-58	C-reactive protein	Homo sapiens	71-89
20734839-3	2010	There was a negative correlation between the level of Zn++ and that of C-reactive protein (CRP) and a positive correlation between the former and the magnitude of a reduction in transferrin (TF) as a marker of protein-energy malnutrition.	Zinc	54-58	C-reactive protein	Homo sapiens	91-94
20138212-5	2010	Treatment of SY5Y neuronal-like cells expressing endogenous TDP-43 with zinc (Zn) induced depletion of TDP-43 expression and formation of inclusions that were TDP-43 positive.	Zinc	78-80	TAR DNA binding protein	Homo sapiens	60-66
20202736-1	2010	Equilibrium self-association of Zn-insulin at pH 7.0 was characterized over the range 0.3-5mg/mL by simultaneous measurement of static and dynamic light scattering.	Zinc	32-34	insulin	Homo sapiens	35-42
20202736-3	2010	The concentration dependence of both quantities may be accounted for to within experimental precision by a simple model, according to which the basic structural unit of Zn-insulin at concentrations exceeding 0.3mg/mL is a hexamer H. With increasing total protein concentration, hexameric protomers may self-associate in accordance with an isodesmic scheme in which a protomer may add to any prexisting oligomer H(n) to form H(n+1) with an invariant stepwise equilibrium association constant.	Zinc	169-171	insulin	Homo sapiens	172-179
19464157-7	2010	The combined treatment of Cd-exposed animals with Se and Zn was more effective than that with either of them alone in reversing Cd-induced decrease in CAT and GSH-Px activities and Cd-induced increase in SOD activity.	Zinc	57-59	catalase	Rattus norvegicus	151-154
20138212-5	2010	Treatment of SY5Y neuronal-like cells expressing endogenous TDP-43 with zinc (Zn) induced depletion of TDP-43 expression and formation of inclusions that were TDP-43 positive.	Zinc	78-80	TAR DNA binding protein	Homo sapiens	103-109
20138212-5	2010	Treatment of SY5Y neuronal-like cells expressing endogenous TDP-43 with zinc (Zn) induced depletion of TDP-43 expression and formation of inclusions that were TDP-43 positive.	Zinc	78-80	TAR DNA binding protein	Homo sapiens	103-109
20138212-6	2010	TDP-43 was also detected in the cytosol of Zn-affected cells but this was not aggregated.	Zinc	43-45	TAR DNA binding protein	Homo sapiens	0-6
20138212-8	2010	The depletion and aggregation of TDP-43 were associated with the specific action of Zn but were not seen with copper, iron, or H(2)O(2).	Zinc	84-86	TAR DNA binding protein	Homo sapiens	33-39
20138212-9	2010	These studies describe for the first time specific induction of endogenous TDP-43 aggregation in neuronal-like cells and suggest that specific Zn-associated processes could affect TDP-43 metabolism in neurodegenerative diseases.	Zinc	143-145	TAR DNA binding protein	Homo sapiens	75-81
20138212-9	2010	These studies describe for the first time specific induction of endogenous TDP-43 aggregation in neuronal-like cells and suggest that specific Zn-associated processes could affect TDP-43 metabolism in neurodegenerative diseases.	Zinc	143-145	TAR DNA binding protein	Homo sapiens	180-186
20215335-3	2010	We here showed that Zn suppresses T(h)17-mediated autoimmune diseases at lest in part by inhibiting the development of T(h)17 cells via attenuating STAT3 activation.	Zinc	20-22	signal transducer and activator of transcription 3	Mus musculus	148-153
20215335-5	2010	IL-6-mediated activation of STAT3 and in vitro T(h)17 cell development were all suppressed by Zn.	Zinc	94-96	interleukin 6	Mus musculus	0-4
20215335-5	2010	IL-6-mediated activation of STAT3 and in vitro T(h)17 cell development were all suppressed by Zn.	Zinc	94-96	signal transducer and activator of transcription 3	Mus musculus	28-33
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	73-78
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	110-115
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	110-115
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	interleukin 6	Mus musculus	205-209
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	interleukin 6 signal transducer	Mus musculus	228-233
20215335-7	2010	Thus, we conclude that Zn suppresses STAT3 activation, which is a critical step for T(h)17 development.	Zinc	23-25	signal transducer and activator of transcription 3	Mus musculus	37-42
20411246-7	2010	In Ussing chamber experiments with rat rectal mucosa, either basolateral or apical application of Zn(2+) (0.1 mM), which inhibited both native ClC-2-like currents and recombinant rClC-2 currents, had little, if any, effects on basal amiloride-sensitive short-circuit current.	Zinc	98-104	chloride voltage-gated channel 2	Rattus norvegicus	143-148
20411246-7	2010	In Ussing chamber experiments with rat rectal mucosa, either basolateral or apical application of Zn(2+) (0.1 mM), which inhibited both native ClC-2-like currents and recombinant rClC-2 currents, had little, if any, effects on basal amiloride-sensitive short-circuit current.	Zinc	98-104	chloride voltage-gated channel 2	Rattus norvegicus	179-185
19369052-8	2010	Likewise, 15 or 30 microg Zn/g diet resulted in maximum relative expression of osteocalcin, without influencing expression of core-binding factor alpha-1, collagen Type 1 alpha-1, or nuclear factor of activated T cells c1.	Zinc	26-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	79-90
20297799-6	2010	The ligand displays an increased selectivity for Zn(II) compared to 1 in the majority of cases with excellent selectivity upheld over Na(I), Mg(II), Ca(II), Mn(II), Ni(II), Co(II), and Fe(III).	Zinc	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-178
20373469-5	2010	However, inhibition of JNK with SP600125 had no effect on Zn-BC-AM PDT-induced apoptosis while inhibition of ERK with PD98059 or p38 MAPK with SB203580 significantly increased Zn-BC-AM PDT-induced apoptosis.	Zinc	176-178	mitogen-activated protein kinase 1	Homo sapiens	109-112
20184893-7	2010	With the exception of the S134N metal-binding variant, the Zn affinity of disulfide-oxidized SOD1 monomers showed little sensitivity to amino acid replacements.	Zinc	59-61	superoxide dismutase 1	Homo sapiens	93-97
20407581-12	2010	Since physiological concentrations of the divalent cation Mg(2+) did not affect the I-V dependence, our data suggest that relief of the voltage-dependent Ca(2+) block of NR1/NR3A receptors by Zn(2+) may be important for the regulation of excitatory glycinergic transmission, according to the Mg(2+)-block of conventional NR1/NR2 NMDA receptors.	Zinc	192-194	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	170-173
20023138-1	2010	The objective of this investigation was to determine associations among rumen endotoxin, plasma serum amyloid A (SAA), and C-reactive protein (CRP) with plasma Ca, Fe, Zn, and Cu in lactating cows challenged with graded amounts of rolled barley grain in the diet (i.e., 0, 15, 30, and 45% of DMI).	Zinc	168-170	C-reactive protein	Bos taurus	143-146
20149802-6	2010	The UVB-induced intracellular Zn(2+) elevation was dependent on the increase of constitutive nitric oxide synthase (cNOS) activity and production of superoxide.	Zinc	30-36	nitric oxide synthase 2	Homo sapiens	93-114
20152387-1	2010	In this paper, a kind of beta-amyloid peptide (Abeta1-16) conjugated gold nanoparticles (Abeta1-16@GNPs) are prepared and employed as colorimetric indicator for studying the interaction of beta-amyloid peptide with metallic ions (e.g. Zn(2+) and Ca(2+)).	Zinc	235-237	amyloid beta precursor protein	Homo sapiens	25-45
20152387-1	2010	In this paper, a kind of beta-amyloid peptide (Abeta1-16) conjugated gold nanoparticles (Abeta1-16@GNPs) are prepared and employed as colorimetric indicator for studying the interaction of beta-amyloid peptide with metallic ions (e.g. Zn(2+) and Ca(2+)).	Zinc	235-237	amyloid beta precursor protein	Homo sapiens	189-209
20152387-3	2010	The experimental results indicate that Zn(2+) can interact with Abeta1-16 and form Zn(2+)-beta-amyloid peptide complexes.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	90-110
20152387-3	2010	The experimental results indicate that Zn(2+) can interact with Abeta1-16 and form Zn(2+)-beta-amyloid peptide complexes.	Zinc	83-85	amyloid beta precursor protein	Homo sapiens	90-110
20152387-4	2010	In particular, in the presence of Zn(2+), a time-dependent interaction of cells with Abeta1-16@GNPs has been observed that may suggest different expression levels of beta-amyloid peptide related proteins in various cell cycles.	Zinc	34-36	amyloid beta precursor protein	Homo sapiens	166-186
20149802-12	2010	SIGNIFICANCE: Our findings not only advance our understanding of the correlations between cNOS activation and Zn elevation, but also elucidated the role of cNOS in regulation of oxidative stress and apoptosis upon UVB-irradiation.	Zinc	110-112	nitric oxide synthase 3	Homo sapiens	90-94
20149802-12	2010	SIGNIFICANCE: Our findings not only advance our understanding of the correlations between cNOS activation and Zn elevation, but also elucidated the role of cNOS in regulation of oxidative stress and apoptosis upon UVB-irradiation.	Zinc	110-112	nitric oxide synthase 3	Homo sapiens	156-160
20149802-6	2010	The UVB-induced intracellular Zn(2+) elevation was dependent on the increase of constitutive nitric oxide synthase (cNOS) activity and production of superoxide.	Zinc	30-36	nitric oxide synthase 3	Homo sapiens	116-120
19371353-1	2010	Our previous studies demonstrate alterations of zinc (Zn) transporter proteins ZnT-1, ZnT-4 and ZnT-6 in vulnerable brain regions of subjects with mild cognitive impairment (MCI), and early and late stage Alzheimer"s disease (AD), suggesting disruptions of Zn homeostasis may play a role in the pathogenesis of AD.	Zinc	54-56	solute carrier family 30 member 1	Homo sapiens	79-84
20048154-4	2010	Using a combination of fluorescent Zn(2+) imaging, small interfering RNA, pharmacological analysis, and cell injury assays, we show that activation of TRPM7 channels augmented Zn(2+)-induced injury of cultured mouse cortical neurons.	Zinc	35-41	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	151-156
20048154-4	2010	Using a combination of fluorescent Zn(2+) imaging, small interfering RNA, pharmacological analysis, and cell injury assays, we show that activation of TRPM7 channels augmented Zn(2+)-induced injury of cultured mouse cortical neurons.	Zinc	176-182	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	151-156
19946718-0	2010	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.	Zinc	57-61	mitogen-activated protein kinase 3	Homo sapiens	70-76
20640797-0	2010	On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.	Zinc	18-20	amyloid beta precursor protein	Homo sapiens	52-72
19946718-1	2010	Zn(2+) exerts insulin-mimetic and antidiabetic effects in rodent models of insulin resistance, and activates extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), key components of the insulin signaling pathway.	Zinc	0-2	insulin	Cricetulus griseus	14-21
19946718-1	2010	Zn(2+) exerts insulin-mimetic and antidiabetic effects in rodent models of insulin resistance, and activates extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), key components of the insulin signaling pathway.	Zinc	0-2	insulin	Cricetulus griseus	75-82
19946718-1	2010	Zn(2+) exerts insulin-mimetic and antidiabetic effects in rodent models of insulin resistance, and activates extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), key components of the insulin signaling pathway.	Zinc	0-2	mitogen-activated protein kinase 3	Homo sapiens	157-163
21069160-5	2010	The Zn-complexes exhibit considerably higher insulin-mimetic activity than the corresponding Mo-analogues.	Zinc	4-6	insulin	Homo sapiens	45-52
19946718-1	2010	Zn(2+) exerts insulin-mimetic and antidiabetic effects in rodent models of insulin resistance, and activates extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), key components of the insulin signaling pathway.	Zinc	0-2	insulin	Cricetulus griseus	75-82
19946718-4	2010	Therefore, using a series of pharmacological inhibitors and genetically engineered cells, we have investigated the roles of various R-PTKs in Zn(2+)-induced ERK1/2 and PKB phosphorylation.	Zinc	142-148	mitogen-activated protein kinase 3	Homo sapiens	157-163
19946718-6	2010	On the other hand, both of these inhibitors were able to attenuate Zn(2+)-induced phosphorylation of ERK1/2 and PKB in A10 vascular smooth muscle cells.	Zinc	67-73	mitogen-activated protein kinase 3	Homo sapiens	101-107
19946718-10	2010	Taken together, these data suggest that distinct R-PTKs mediate Zn(2+)-evoked ERK1/2 and PKB phosphorylation in a cell-specific manner.	Zinc	64-70	mitogen-activated protein kinase 3	Homo sapiens	78-84
20055470-4	2010	Four of the complexes MCl(2)tripbipy (M = Fe, Co, Ni, Zn) crystallize in the space group P2(1)/c and are isomorphous with one solvent molecule of crystallization.	Zinc	54-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-94
19852955-5	2010	We documented that over-expression of Zip6 was associated with significantly higher cellular Zn levels in tumor cells compared with normal breast cells.	Zinc	93-95	solute carrier family 39 member 6	Homo sapiens	38-42
20163680-5	2010	We here show that fibromodulin, fibronectin and laminin bind to myostatin in the presence of Zn(2+) with a dissociation constant (K(D)) of 10(-10) approximately 10(-8) mol/L.	Zinc	93-95	fibronectin 1	Homo sapiens	32-43
20163680-5	2010	We here show that fibromodulin, fibronectin and laminin bind to myostatin in the presence of Zn(2+) with a dissociation constant (K(D)) of 10(-10) approximately 10(-8) mol/L.	Zinc	93-95	myostatin	Homo sapiens	64-73
19769955-0	2010	Genotyping and mapping assay of single-nucleotide polymorphisms in CYP3A5 using DNA-binding zinc(II) complexes.	Zinc	92-100	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	67-73
19769955-5	2010	RESULTS: Zn(2+)-Phos-tag PAGE permitted identification of the following allele genotypes: the A/A homozygote (CYP3A51/1) in 3 individuals, the G/G homozygote (CYP3A53/3) in 14 individuals, and the A/G heterozygote (CYP3A51/3) in 2 individuals.	Zinc	9-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	159-168
19769955-5	2010	RESULTS: Zn(2+)-Phos-tag PAGE permitted identification of the following allele genotypes: the A/A homozygote (CYP3A51/1) in 3 individuals, the G/G homozygote (CYP3A53/3) in 14 individuals, and the A/G heterozygote (CYP3A51/3) in 2 individuals.	Zinc	9-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	215-224
19769955-7	2010	CONCLUSION: We demonstrated reliable SNP genotyping and mapping in CYP3A5 using the combination method of Zn(2+)-Phos-tag PAGE and Zn(2+)-cyclen PAGE.	Zinc	106-108	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	67-73
19680705-3	2010	METHODS: Cells were apically treated with Zn (25 muM) and vitamins (Folic acid (FA), Nicotinic acid (NA), Ascorbic acid (AA), riboflavin, thiamine, pyridoxine) for 60 min.	Zinc	42-44	latexin	Homo sapiens	49-52
19852955-7	2010	Zip6-attenuation significantly reduced cellular Zn pools, which was associated with increased mitochondrial membrane potential (DeltaPsim) and decreased apoptotic stimuli (cytoplasmic cytochrome C release, caspase-3 and -9 activities).	Zinc	48-50	solute carrier family 39 member 6	Homo sapiens	0-4
20414461-3	2010	The results of electronic spectra and magnetic moment measurements indicate that Mn(II), Co(II), and Ni(II) complexes show octahedral geometry, while Cu(II) and Zn(II) complexes show square planar and tetrahedral geometry, respectively.	Zinc	161-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	28-30	ribosomal protein L5	Homo sapiens	217-221
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	150-152	ribosomal protein L5	Homo sapiens	217-221
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	150-152	ribosomal protein L5	Homo sapiens	217-221
20039701-6	2010	The BS-caged-L(6) was reactivated by hydrolysis of the benzenesulfonyl moiety more rapidly (completes in 30 min at pH 7.4 at 37 degrees C) than BS-caged-L(5), presumably enabling the practical detection of Zn(2+) in sample solutions and living cells.	Zinc	206-208	ribosomal protein L5	Homo sapiens	153-157
19834746-2	2010	Glx2-2-containing fractions that were purple, yellow, or colorless were separated during purification, and the differently colored fractions were found to contain different amounts of Fe and Zn(II).	Zinc	191-197	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	0-6
19819236-6	2010	Zn(2+) significantly reduced ion secretion elicited by carbachol (-87%) or by interferon-gamma (-100%), and inhibited the increase of intracellular Ca(2+) and nitric oxide concentrations.	Zinc	0-2	interferon gamma	Homo sapiens	78-94
19954165-6	2010	(1)H NMR studies indicate that the 3-Hfl complexes of Co(II), Ni(II), and Zn(II) exhibit a pseudo-octahedral geometry in solution.	Zinc	74-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-60
20689703-3	2010	The RING finger domain of Arkadia is a RING-H2 type and its structure and stability is strongly dependent on the presence of two bound Zn(II) ions attached to the protein frame through a defined Cys3-His2-Cys3 motif.	Zinc	135-141	ring finger protein 111	Homo sapiens	26-33
20065150-6	2010	ACE inhibitors are also agonists of the B1R, at a Zn-binding sequence on the second extracellular loop that differs from the orthosteric binding site of the des-Arg-kinin peptide ligands.	Zinc	50-52	angiotensin I converting enzyme	Homo sapiens	0-3
20065150-6	2010	ACE inhibitors are also agonists of the B1R, at a Zn-binding sequence on the second extracellular loop that differs from the orthosteric binding site of the des-Arg-kinin peptide ligands.	Zinc	50-52	bradykinin receptor B1	Homo sapiens	40-43
21069147-13	2010	In this work, there is clear competition between and Fe(3+) and Zn(2+) for binding in the C-terminus lobe of Tf, while Ni(2+) binds within the N-terminus lobe.	Zinc	64-70	transferrin	Homo sapiens	109-111
20634989-4	2010	Following our previous work, synthetic peptides and Zinc(II) metal ions are used to build structural maquettes of the two Zn-catalytic active sites of the ACE somatic isoform.	Zinc	52-60	angiotensin I converting enzyme	Homo sapiens	155-158
20634989-4	2010	Following our previous work, synthetic peptides and Zinc(II) metal ions are used to build structural maquettes of the two Zn-catalytic active sites of the ACE somatic isoform.	Zinc	122-124	angiotensin I converting enzyme	Homo sapiens	155-158
20423300-11	2010	Glial subtypes might be specifically distinguished by interfering Zn2+ binding in the second extracellular loop of hGAT-3.	Zinc	66-70	solute carrier family 6 member 13	Homo sapiens	115-121
19769985-4	2009	The structure of the HypA monomer consists of Ni- and Zn-binding domains.	Zinc	54-56	hydrogenase nickel incorporation protein HypA	Thermococcus kodakarensis KOD1	21-25
21417790-1	2010	BACKGROUND: Complexation of five metal cations, Fe(3+), Al(3+), Zn(2+), Cu(2+) and Mg(2+) with four fluoroquinolones, levofloxacin, sparfloxacin, ciprofloxacin hydrochloride and enrofloxacin and human serum albumin (HSA) has been studied for better understanding of bioavailability of drugs interacting with metals and proteins.	Zinc	64-70	albumin	Homo sapiens	201-214
19784710-7	2010	Reductions in cellular Zn triggered a translocation of the pro-apoptotic protein Bad to the mitochondria, cytochrome c release, and caspase-3 activation.	Zinc	23-25	cytochrome c, somatic	Homo sapiens	106-118
19784710-7	2010	Reductions in cellular Zn triggered a translocation of the pro-apoptotic protein Bad to the mitochondria, cytochrome c release, and caspase-3 activation.	Zinc	23-25	caspase 3	Homo sapiens	132-141
27713232-2	2009	The [14C]Gly-Sar uptake via PEPT1 was inhibited by Zn2+ and Cu2+ treatment in a concentration-dependent manner (Ki values 107 +- 23 and 19 +- 5 muM, respectively).	Zinc	51-55	solute carrier family 15 member 1	Homo sapiens	28-33
27713232-2	2009	The [14C]Gly-Sar uptake via PEPT1 was inhibited by Zn2+ and Cu2+ treatment in a concentration-dependent manner (Ki values 107 +- 23 and 19 +- 5 muM, respectively).	Zinc	51-55	latexin	Homo sapiens	144-147
19877597-3	2009	The introduction of the pyridyl pendants in bcpe provokes a very important increase of the logK(ML) values obtained for the Pb(II) and Cd(II) complexes, while this effect is less important in the case of the Zn(II) analogue.	Zinc	208-214	submaxillary gland androgen regulated protein 3B	Homo sapiens	124-130
20364581-6	2010	The decreased of Cu/Zn ratio could induce the decrease of the CAT activity in the rat blood, while there were no linear correlation be found between them.	Zinc	20-22	catalase	Rattus norvegicus	62-65
20030848-1	2009	BACKGROUND: ZnT3 is a membrane Zn(2+ )transporter that is responsible for concentrating Zn(2+ )into neuronal presynaptic vesicles.	Zinc	31-38	solute carrier family 30 member 3	Homo sapiens	12-16
19877000-2	2009	Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid-beta (Abeta), and 2) production of reactive oxygen species (ROS) induced by Abeta.	Zinc	4-6	amyloid beta precursor protein	Homo sapiens	121-140
19877000-2	2009	Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid-beta (Abeta), and 2) production of reactive oxygen species (ROS) induced by Abeta.	Zinc	4-6	amyloid beta precursor protein	Homo sapiens	127-132
19877000-3	2009	There is compelling evidence that Cu and Zn bind directly to Abeta in AD.	Zinc	41-43	amyloid beta precursor protein	Homo sapiens	61-66
19877000-6	2009	Moreover, the mechanism of ROS production by Cu-Abeta in relation to its aggregations state, as well as the metal-transfer reaction from and to Abeta are crucial in order to understand why Abeta oligomers are highly toxic and why Abeta seems to bind Cu and Zn only in AD.	Zinc	257-259	amyloid beta precursor protein	Homo sapiens	48-53
19877000-6	2009	Moreover, the mechanism of ROS production by Cu-Abeta in relation to its aggregations state, as well as the metal-transfer reaction from and to Abeta are crucial in order to understand why Abeta oligomers are highly toxic and why Abeta seems to bind Cu and Zn only in AD.	Zinc	257-259	amyloid beta precursor protein	Homo sapiens	144-149
19877000-6	2009	Moreover, the mechanism of ROS production by Cu-Abeta in relation to its aggregations state, as well as the metal-transfer reaction from and to Abeta are crucial in order to understand why Abeta oligomers are highly toxic and why Abeta seems to bind Cu and Zn only in AD.	Zinc	257-259	amyloid beta precursor protein	Homo sapiens	144-149
19877000-6	2009	Moreover, the mechanism of ROS production by Cu-Abeta in relation to its aggregations state, as well as the metal-transfer reaction from and to Abeta are crucial in order to understand why Abeta oligomers are highly toxic and why Abeta seems to bind Cu and Zn only in AD.	Zinc	257-259	amyloid beta precursor protein	Homo sapiens	144-149
19877597-8	2009	A detailed investigation of the structure in aqueous solution of the complexes by using nuclear magnetic resonance (NMR) techniques and density functional theory (DFT) calculations (B3LYP) shows that while in the Zn(II) complex the metal ion is six-coordinated, in the Pb(II) and Ca(II) analogues the metal ions are eight-coordinated.	Zinc	213-219	submaxillary gland androgen regulated protein 3B	Homo sapiens	269-275
19822897-2	2009	The latter was released constitutively from HUVECs and cleaved the secreted and cell-anchored VWF strings progressively during 15 minutes in Ca(2+)/Zn(2+)-containing buffer.	Zinc	148-154	von Willebrand factor	Homo sapiens	94-97
19830795-7	2009	The NMR structural analysis of the apo STR-W14 revealed that the conformation in the C-terminus GXXH region significantly differred between the apo state in the micelle and the reported Zn-bound state of stromelysin-1 in crystal structures.	Zinc	186-188	matrix metallopeptidase 3	Homo sapiens	204-217
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	53-55	cytochrome c, somatic	Homo sapiens	147-159
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	cytochrome c, somatic	Homo sapiens	147-159
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	cytochrome c, somatic	Homo sapiens	147-159
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	cytochrome c, somatic	Homo sapiens	147-159
19853303-2	2009	In this work the effects of Cu(II) and Zn(II) ions on heat-induced structural modifications of bovine serum albumin (BSA) were studied, with the aim of delineating the role of these ions in the early stages of proteins aggregation kinetics.	Zinc	39-45	albumin	Homo sapiens	102-115
20333873-1	2009	AIM: To determine the effect of zinc (Zn) therapy on serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in children with Zn deficiency and growth retardation, but without systemic disease, and to investigate the effect of Zn supplementation on these parameters.	Zinc	38-40	insulin like growth factor 1	Homo sapiens	59-87
20333873-1	2009	AIM: To determine the effect of zinc (Zn) therapy on serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in children with Zn deficiency and growth retardation, but without systemic disease, and to investigate the effect of Zn supplementation on these parameters.	Zinc	38-40	insulin like growth factor 1	Homo sapiens	89-94
20333873-6	2009	After Zn therapy, serum IGF-I levels were increased in 62% of the children; this increase was statistically significant in 48.3% of the children.	Zinc	6-8	insulin like growth factor 1	Homo sapiens	24-29
19850345-11	2009	These results indicate that the anti-inflammatory effect of thymulin, which is mediated by cAMP, is NF-kappaB-dependent and involves the downregulation of the release of proinflammatory cytokines, particularly IL-1beta, an effect synergistically amplified, at least in part, by Zn(2+).	Zinc	278-280	nuclear factor kappa B subunit 1	Homo sapiens	100-109
20333873-10	2009	CONCLUSION: Serum IGF-I and IGFBP-3 levels were decreased in children with Zn deficiency, and were increased after Zn supplementation.	Zinc	75-77	insulin like growth factor 1	Homo sapiens	18-23
20333873-11	2009	In addition, after Zn supplementation, increment of serum IGF-I levels was found to be higher in children with low BMI than those with normal BMI; therefore, the nutritional status of children may also be important, as well as Zn supplementation.	Zinc	19-21	insulin like growth factor 1	Homo sapiens	58-63
19850345-0	2009	Thymulin and zinc (Zn2+)-mediated inhibition of endotoxin-induced production of proinflammatory cytokines and NF-kappaB nuclear translocation and activation in the alveolar epithelium: unraveling the molecular immunomodulatory, anti-inflammatory effect of thymulin/Zn2+ in vitro.	Zinc	19-23	nuclear factor kappa B subunit 1	Homo sapiens	110-119
19850345-4	2009	Furthermore, Zn(2+), an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, independently reduced the secretion of IL-1beta, TNF-alpha and, to a lesser extent, at a supraphysiologic dose (1 mM), IL-6.	Zinc	13-18	interleukin 1 beta	Homo sapiens	153-161
19850345-4	2009	Furthermore, Zn(2+), an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, independently reduced the secretion of IL-1beta, TNF-alpha and, to a lesser extent, at a supraphysiologic dose (1 mM), IL-6.	Zinc	13-18	tumor necrosis factor	Homo sapiens	163-172
19788901-4	2009	By using this system hSOD1 was obtained in a soluble active form after addition of Cu(2+) and Zn(2+) and was purified with a yield of approximately 33 microg from 1 ml of reaction volume.	Zinc	94-96	superoxide dismutase 1	Homo sapiens	21-26
19005769-3	2009	The Zn concentration classes estimated by CART assigned the right classes with an accuracy of near 90%.	Zinc	4-6	CART prepropeptide	Homo sapiens	42-46
20353074-2	2009	Correlation analysis showed that the total and available contents of soil Cu, Cd, Pb and Zn had significant positive correlations with the activities of soil urease, cellulase, alkaline phosphomonoesterase and polyphenol oxidase, but significant negative correlation with the activity of soil catalase.	Zinc	89-91	alkaline phosphatase, placental	Homo sapiens	177-205
20353074-2	2009	Correlation analysis showed that the total and available contents of soil Cu, Cd, Pb and Zn had significant positive correlations with the activities of soil urease, cellulase, alkaline phosphomonoesterase and polyphenol oxidase, but significant negative correlation with the activity of soil catalase.	Zinc	89-91	catalase	Homo sapiens	293-301
20353074-4	2009	Path analysis showed that Cu, Cd, Pb and Zn pollution promoted the activities of soil urease, cellulase and polyphenol oxidase, but had less effects on the activity of soil alkaline phosphomonoesterase.	Zinc	41-43	alkaline phosphatase, placental	Homo sapiens	173-201
20353074-5	2009	Soil available Cu, Cd, Pb and Zn didn"t directly affect the activity of soil catalase, but indirectly inhibited it significantly.	Zinc	30-32	catalase	Homo sapiens	77-85
19850345-4	2009	Furthermore, Zn(2+), an anti-inflammatory antioxidant, which is required for the biological activity of thymulin, independently reduced the secretion of IL-1beta, TNF-alpha and, to a lesser extent, at a supraphysiologic dose (1 mM), IL-6.	Zinc	13-18	interleukin 6	Homo sapiens	233-237
19859616-4	2009	The order of reactivity for the M(II)-substituted species is Pd(II) &gt; Zn(II) &gt; Co(II) &gt; Ni(II), and for M(III) and M(IV) substitution is Mn(III) approximately Ir(IV) &gt; Fe(III) &gt; Cr(III).	Zinc	73-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
19798717-1	2009	The systematic exploration of the modification of polyethylene imine with guanidinium and octyl groups has led to the identification of a catalyst, CD6, which accelerates the phosphate transfer reaction of HPNP (2-hydroxypropyl-4-nitrophenyl phosphate) in the presence of divalent metals such as Zn(2+), Co(2+), Mg(2+) or Ni(2+).	Zinc	296-298	CD6 molecule	Homo sapiens	148-151
19798717-5	2009	This effect stands in contrast to Zn(II)-catalysed transesterification of HPNP in water or by the synzymes Co(II)-CD6 and Ni(II)-CD6, with which no such interference by product is observed.	Zinc	34-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-117
19798717-5	2009	This effect stands in contrast to Zn(II)-catalysed transesterification of HPNP in water or by the synzymes Co(II)-CD6 and Ni(II)-CD6, with which no such interference by product is observed.	Zinc	34-40	CD6 molecule	Homo sapiens	114-117
19716810-1	2009	Using fluorescence and UV-vis spectroscopies and mass spectrometry, we demonstrated that the presence of physiological levels of reduced glutathione enhances the binding of Zn(II) to XPAzf, a Cys4 zinc finger peptide derived from the XPA protein, by means of formation of a ternary complex of a general formula ZnXPAzf[GSH].	Zinc	173-175	XPA, DNA damage recognition and repair factor	Homo sapiens	183-186
19780525-0	2009	Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue.	Zinc	97-105	amyloid beta precursor protein	Homo sapiens	26-31
19780525-4	2009	In this work, we used a combined potentiometric, NMR, and electrospray ionization mass spectrometry (ESI-MS) approach to study the zinc(II) binding to a new polyethylene glycol (PEG)-conjugated peptide fragment encompassing the 1-16 amino acid sequence of Abeta (Abeta(1-16)PEG).	Zinc	131-139	amyloid beta precursor protein	Homo sapiens	256-261
19780525-6	2009	The study was complemented by systematically investigating the zinc(II) complexes of a series of shorter peptide fragments related to the Abeta(1-16) sequence, namely, Abeta(1-4), Abeta(1-6), AcAbeta(1-6), AcAbeta(8-16)Y10A.	Zinc	63-71	amyloid beta precursor protein	Homo sapiens	138-143
19780525-6	2009	The study was complemented by systematically investigating the zinc(II) complexes of a series of shorter peptide fragments related to the Abeta(1-16) sequence, namely, Abeta(1-4), Abeta(1-6), AcAbeta(1-6), AcAbeta(8-16)Y10A.	Zinc	63-71	amyloid beta precursor protein	Homo sapiens	168-173
19780525-6	2009	The study was complemented by systematically investigating the zinc(II) complexes of a series of shorter peptide fragments related to the Abeta(1-16) sequence, namely, Abeta(1-4), Abeta(1-6), AcAbeta(1-6), AcAbeta(8-16)Y10A.	Zinc	63-71	amyloid beta precursor protein	Homo sapiens	168-173
19780525-7	2009	The comparison of the whole results allowed the identification of the zinc(II) preferred binding sites within the longer Abeta(1-16) amino acid sequence.	Zinc	70-78	amyloid beta precursor protein	Homo sapiens	121-126
19679159-3	2009	A large body of evidence suggests that Zn(2+) ions stimulate HRG-complex formation; however, under normal conditions the vast majority of Zn(2+) in the blood is bound to human serum albumin (HSA).	Zinc	138-140	albumin	Homo sapiens	176-189
19530166-9	2009	Because zip4 levels are regulated by dietary Zn, our studies suggest that the brain has the potential of adapting to changes in Zn status.	Zinc	45-47	solute carrier family 39 member 4	Rattus norvegicus	8-12
19530166-9	2009	Because zip4 levels are regulated by dietary Zn, our studies suggest that the brain has the potential of adapting to changes in Zn status.	Zinc	128-130	solute carrier family 39 member 4	Rattus norvegicus	8-12
20039004-4	2009	Importantly, to date, our group has only been able to elicit these beneficial effects when the C-peptide is prepared in the presence of Zn2+.	Zinc	136-140	insulin	Homo sapiens	95-104
19656958-4	2009	Concentrations and yields of Ca, P, Mg, Na, K, Fe, and Zn in milk of 46 red deer hinds were monitored through 18 weeks of lactation.	Zinc	55-57	Weaning weight-maternal milk	Bos taurus	61-65
19746486-8	2009	This is caused by the strong 1:1 binding of the two deprotonated thymine groups in TpT to different Zn(II) centres of receptor 1.	Zinc	100-102	limb development membrane protein 1	Homo sapiens	83-86
19770501-4	2009	The observed double conformation of GluB13 was essential to interpreting the charge balance and could be compared with the structure of a dried crystal of T(6) human insulin at 100 K. Differences in the dynamic behaviour of the water molecules coordinating the upper and lower Zn ions were observed and interpreted.	Zinc	277-279	insulin	Homo sapiens	166-173
19778152-2	2009	NMR spectra show that TIS11d(TZF) undergoes a transition from disordered to well folded upon binding to Zn and mRNA.	Zinc	104-106	zinc finger protein 318	Homo sapiens	29-32
19805293-6	2009	The N-terminal 616 aa of CBP, which includes the conserved Zn(2+)-binding C/H1-TAZ1 domain, was the minimal domain sufficient to destabilize p53 in vivo, and it included within an intrinsic E3 autoubiquitination activity and, in a two-step E4 assay, exhibited robust E4 activity for p53.	Zinc	59-65	CREB binding protein	Homo sapiens	25-28
19805293-6	2009	The N-terminal 616 aa of CBP, which includes the conserved Zn(2+)-binding C/H1-TAZ1 domain, was the minimal domain sufficient to destabilize p53 in vivo, and it included within an intrinsic E3 autoubiquitination activity and, in a two-step E4 assay, exhibited robust E4 activity for p53.	Zinc	59-65	tumor protein p53	Homo sapiens	141-144
19681600-7	2009	Substitutions at Zn-coordinating cysteines C176, C238, or C242 resulted in p53 inactivation.	Zinc	17-19	tumor protein p53	Homo sapiens	75-78
19692239-0	2009	Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.	Zinc	56-58	matrix metallopeptidase 13	Homo sapiens	69-75
19692239-1	2009	Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported.	Zinc	63-65	matrix metallopeptidase 13	Homo sapiens	76-82
19622611-4	2009	While Zn(2+) was previously shown to activate p38, we show here that this metal inhibits cytoplasmic protein tyrosine phosphatase (Cyt-PTPepsilon), which specifically targets Y124.	Zinc	6-8	mitogen-activated protein kinase 14	Homo sapiens	46-49
19624124-0	2009	Homodimerization and heterodimerization of minimal zinc(II)-binding-domain peptides of T-cell proteins CD4, CD8alpha, and Lck.	Zinc	51-59	CD4 molecule	Homo sapiens	103-106
19630406-5	2009	Spectroscopic and X-ray crystallographic studies indicate that the sulfonate group within the stereogenic-at-Zn bidentate complexes coordinates syn to the proximal phenyl substituent of the NHC backbone (vs the initially expected anti).	Zinc	109-111	high mobility group nucleosomal binding domain 4	Homo sapiens	190-193
19490425-6	2009	Zn treatment dramatically increased the expression of the metallothionein (Mt), and modestly increased the expression of acute-phase protein genes (ceruloplasmin, Stat3, egr1, Cxc chemokines and heat-shock proteins).	Zinc	0-2	early growth response 1	Rattus norvegicus	170-174
19490425-12	2009	CONCLUSION: Such gene expression changes, particularly the dramatic induction of MT and Nrf2 antioxidant pathway, occur in the absence of overt liver injury, and are probably important in the hepatoprotective effects of Zn against toxic insults.	Zinc	220-222	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
19630406-0	2009	Stereogenic-at-metal Zn- and Al-based N-heterocyclic carbene (NHC) complexes as bifunctional catalysts in Cu-free enantioselective allylic alkylations.	Zinc	21-23	high mobility group nucleosomal binding domain 4	Homo sapiens	38-66
18795241-4	2009	The enzyme had an optimal temperature of 25 degrees C and was relatively stable at 20-30 degrees C. Reducing sodium metabisulfite, ascorbic acid, dithiothreitol, SnCl(2), and FeCl(3) markedly inhibited PPO activity, whereas its activity was highly enhanced by Mg(2+), Ca(2+), and Mn(2+) and was moderately inhibited by Ba(2+), Cu(2+), and Zn(2+).	Zinc	339-341	polyphenol oxidase, chloroplastic-like	Gossypium hirsutum	202-205
19809679-0	2009	Modeling of the Zn2+ binding in the 1-16 region of the amyloid beta peptide involved in Alzheimer"s disease.	Zinc	16-20	amyloid beta precursor protein	Homo sapiens	55-67
19549187-0	2009	Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+.	Zinc	127-131	amyloid beta precursor protein	Homo sapiens	61-73
19549187-2	2009	Divalent metal ions such as Cu(2+) and Zn(2+) are known to significantly affect the rate of aggregation and morphology of Abeta assemblies in vitro and are also found at elevated levels within cerebral plaques in vivo.	Zinc	39-41	amyloid beta precursor protein	Homo sapiens	122-127
19549187-6	2009	Our results suggest that Abeta in complex with either Cu(2+) or Zn(2+) can attain an aggregation-prone beta-strand-turn-beta-strand motif, similar to the motif found in fibrils, but where the metal binding to the N-terminal region guides the peptide into an assembly distinctly different from the fibril form.	Zinc	64-66	amyloid beta precursor protein	Homo sapiens	25-30
19037857-0	2009	Insights into the mechanism of methionine oxidation catalyzed by metal (Cu(2+), Zn(2+), and Fe(3+)) - amyloid beta (Abeta) peptide complexes: A computational study.	Zinc	80-82	amyloid beta precursor protein	Homo sapiens	116-121
19491923-2	2009	The results of our recent works suggest that the OGD/R-induced Zn2+ transient can readily be mistaken for a Ca2+ transient.	Zinc	63-67	carbonic anhydrase 2	Rattus norvegicus	108-111
19491923-5	2009	Ca2+ accumulation induced with high [K+] (to open voltage-gated calcium channels) or ionomycin (a Ca2+ ionophore) caused a moderate neuronal injury that was reduced significantly by the application of the Zn2+ chelator N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN).	Zinc	205-209	carbonic anhydrase 2	Rattus norvegicus	0-3
19491923-5	2009	Ca2+ accumulation induced with high [K+] (to open voltage-gated calcium channels) or ionomycin (a Ca2+ ionophore) caused a moderate neuronal injury that was reduced significantly by the application of the Zn2+ chelator N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN).	Zinc	205-209	carbonic anhydrase 2	Rattus norvegicus	98-101
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Zinc	374-376	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-161
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Zinc	374-376	acetylcholinesterase (Cartwright blood group)	Homo sapiens	163-167
19485411-2	2009	The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain.	Zinc	374-376	amyloid beta precursor protein	Homo sapiens	220-245
19037857-1	2009	In this DFT study, a mechanism of the oxidation of methionine (Met) amino acid residue catalyzed by the metal (Cu(2+), Zn(2+), and Fe(3+)) bound amyloid beta (Abeta) peptide has been proposed.	Zinc	119-121	amyloid beta precursor protein	Homo sapiens	159-164
19285387-6	2009	The metal ions Ca(2+), Mg(2+) and Mn(2+) had stimulatory effect on lipase activity, whereas Cu(2+), Fe(2+) and Zn(2+) strongly inhibited the lipase activity.	Zinc	111-113	DM80_RS12985	Burkholderia multivorans	141-147
19476316-6	2009	At temperatures below 200 K Zn(5)Sb(4)In(2-delta) undergoes a phase transition into a more ordered structure with monoclinic symmetry (P2(1)/c) without any change of the unit cell.	Zinc	28-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	135-142
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Zinc	133-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	173-179
19453299-7	2009	Examination of the molecular signaling mechanism leading to this early Zn(2+) signal revealed a critical role for protein kinase C (PKC) activity, suggesting that PKC may act directly on the intracellular source of Zn(2+).	Zinc	71-73	proline rich transmembrane protein 2	Homo sapiens	114-130
19515425-0	2009	Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions--potentiometric and NMR studies.	Zinc	73-77	arginine vasopressin	Homo sapiens	36-47
19515425-1	2009	We have characterized the interaction between the Zn(2+) ions and the histidine analogues of oxytocin and arginine-vasopressin.	Zinc	50-56	arginine vasopressin	Homo sapiens	115-126
19798981-7	2009	When the ratio of Mb and metal ions is 1 : 10, the interaction intension between the three metal ions and Mb is Co(II), Zn(II) and Cu(II) in turn.	Zinc	120-126	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-118
19542470-7	2009	Because S100A12 binds Zn(2+), we studied some functional aspects that could modulate atherogenesis.	Zinc	22-24	S100 calcium binding protein A12	Homo sapiens	8-15
19542470-8	2009	S100A12 formed a hexamer in the presence of Zn(2+); a novel Ab was generated that specifically recognized this complex.	Zinc	44-46	S100 calcium binding protein A12	Homo sapiens	0-7
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	13-15	S100 calcium binding protein A12	Homo sapiens	21-28
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	13-15	matrix metallopeptidase 3	Homo sapiens	71-76
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	13-15	S100 calcium binding protein A12	Homo sapiens	101-108
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	86-88	S100 calcium binding protein A12	Homo sapiens	21-28
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	86-88	matrix metallopeptidase 3	Homo sapiens	71-76
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	86-88	S100 calcium binding protein A12	Homo sapiens	101-108
19542470-10	2009	S100A12 may represent a new marker of this disease and may protect advanced atherosclerotic lesions from rupture by inhibiting excessive MMP-2 and MMP-9 activities by sequestering Zn(2+).	Zinc	180-182	S100 calcium binding protein A12	Homo sapiens	0-7
19453299-7	2009	Examination of the molecular signaling mechanism leading to this early Zn(2+) signal revealed a critical role for protein kinase C (PKC) activity, suggesting that PKC may act directly on the intracellular source of Zn(2+).	Zinc	71-73	proline rich transmembrane protein 2	Homo sapiens	163-166
19453299-7	2009	Examination of the molecular signaling mechanism leading to this early Zn(2+) signal revealed a critical role for protein kinase C (PKC) activity, suggesting that PKC may act directly on the intracellular source of Zn(2+).	Zinc	71-74	proline rich transmembrane protein 2	Homo sapiens	114-130
19453299-7	2009	Examination of the molecular signaling mechanism leading to this early Zn(2+) signal revealed a critical role for protein kinase C (PKC) activity, suggesting that PKC may act directly on the intracellular source of Zn(2+).	Zinc	71-74	proline rich transmembrane protein 2	Homo sapiens	163-166
19453299-8	2009	We identified a conserved PKC phosphorylation site at serine-32 (S32) of metallothionein (MT) that was important in modulating Zn(2+)-regulated gene expression and conferring excitotoxic tolerance.	Zinc	127-129	proline rich transmembrane protein 2	Homo sapiens	26-29
19481806-4	2009	Circular dichroism (CD) studies and metal assays showed that two versions of TRAIL folded as predicted into secondary and tertiary structures, and contained stoichiometric Zn(2+) through optimizing bacterial expression and purification.	Zinc	172-174	TNF superfamily member 10	Homo sapiens	77-82
19497878-1	2009	The structural integrity of the ubiquitous enzyme superoxide dismutase (SOD1) relies critically on the correct coordination of Cu and Zn.	Zinc	134-136	superoxide dismutase 1	Homo sapiens	72-76
19487805-3	2009	The microsized grains of the commercially available ZnO:Zn (P 15) were reduced to the nanometre scale by pulsed laser ablation at an oxygen ambient pressure of 10 kPa.	Zinc	52-54	cyclin dependent kinase inhibitor 2B	Homo sapiens	60-64
19497878-3	2009	We examine here the consequences of Zn(2+) loss by selectively removing the Zn site, which has been implicated as the main modulator of SOD1 stability and disease competence.	Zinc	36-38	superoxide dismutase 1	Homo sapiens	136-140
19497878-3	2009	We examine here the consequences of Zn(2+) loss by selectively removing the Zn site, which has been implicated as the main modulator of SOD1 stability and disease competence.	Zinc	76-78	superoxide dismutase 1	Homo sapiens	136-140
19517273-2	2009	In the present study, the potential of Zn2+ and Cu2+ to induce interleukin (IL)-6 responses in cardiomyocytes (CMs) and cardiac fibroblasts (CFs), in mono- and cocultures, was examined.	Zinc	39-43	interleukin 6	Rattus norvegicus	63-81
19517273-8	2009	Treatment with a p38 inhibitor (SB202190) reduced the IL-6 responses to Zn2+ and Cu2+ in both cell types.	Zinc	72-76	interleukin 6	Rattus norvegicus	54-58
19517273-10	2009	In conclusion, Zn2+ and Cu2+ increased IL-6 release and MAP-kinase activation in primary cardiac cells, processes known to be involved in cardiac inflammation and hypertrophy.	Zinc	15-19	interleukin 6	Rattus norvegicus	39-43
19490087-7	2009	This L-LTP was partially reversed by high-intensity paired-pulse low-frequency stimulation (HI-PP-LFS) and was inhibited by Zn(2+) (30 nm), a voltage-independent NR2A-NMDAR antagonist.	Zinc	124-126	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	162-166
19463741-11	2009	These results suggest that dispersal of hexameric insulin through chelation of Zn(2+) contributes to the hypoglycemic activity of these tetrapeptides.	Zinc	79-81	insulin	Homo sapiens	50-57
19349076-3	2009	Some reports suggest that Zn(2+)-induced depolarization results from the opening of the mitochondrial permeability transition pore (mPTP).	Zinc	26-32	protein tyrosine phosphatase, receptor type, U	Mus musculus	132-136
19399766-1	2009	Electrospray ionization mass spectrometry (ESI-MS) is used to probe the metal-binding selectivity of a macrocyclic thiacrown ether (C(44)H(32)S(20)) towards Co(II), Ni(II), Cu(II), and Zn(II).	Zinc	185-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-163
19326938-1	2009	ATR-FTIR and EXAFS study of the aqueous Zn(II)/oxalate/hematite ternary system.	Zinc	40-46	ATR serine/threonine kinase	Homo sapiens	0-3
19326938-7	2009	In the Zn(II)/Ox/HN ternary system at R=0.15, ATR-FTIR results indicate the presence of inner-sphere oxalate and outer-sphere ZnOx(aq) complexes; the EXAFS results provide no evidence for inner-sphere Zn(II) complexes or type A ternary complexes.	Zinc	7-9	ATR serine/threonine kinase	Homo sapiens	46-49
19326938-8	2009	In contrast, ATR-FTIR results for the Zn/Ox/HN sample with R = 0.68 are consistent with a ZnOx(s)-like surface precipitate and possibly type B ternary surface complexes (i.e., &gt;O2-Ox-Zn).	Zinc	38-40	ATR serine/threonine kinase	Homo sapiens	13-16
19352532-2	2009	Dysfunctional interactions of metal ions, especially those of Cu, Zn, and Fe, with the amyloid-beta (Abeta) peptide are hypothesised to play an important role in the aetiology of AD, and disruption of these aberrant metal-peptide interactions via chelation therapy holds considerable promise as a therapeutic strategy.	Zinc	66-68	amyloid beta precursor protein	Homo sapiens	87-99
19721908-8	2009	Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased.	Zinc	74-76	interleukin 6	Homo sapiens	103-106
19721908-8	2009	Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased.	Zinc	74-76	C-reactive protein	Homo sapiens	151-155
19127548-5	2009	The roles that IDE/insulin concentration ratio, reaction time, adenosine 5"-triphosphate (ATP) and metal ions (Zn and Cu) have on the insulin cleavage pattern produced by IDE are investigated and a plausible interpretation involving the proteolytic action of the different IDE oligomeric forms is proposed.	Zinc	111-113	insulin	Homo sapiens	134-141
19352532-2	2009	Dysfunctional interactions of metal ions, especially those of Cu, Zn, and Fe, with the amyloid-beta (Abeta) peptide are hypothesised to play an important role in the aetiology of AD, and disruption of these aberrant metal-peptide interactions via chelation therapy holds considerable promise as a therapeutic strategy.	Zinc	66-68	amyloid beta precursor protein	Homo sapiens	101-106
19352532-3	2009	Tetrahydrosalens such as (2)(1-5) have a significant affinity for metal ions, and thus should be able to compete with the Abeta peptide for Cu, Zn, and Fe in the brain.	Zinc	144-146	amyloid beta precursor protein	Homo sapiens	122-127
19255120-9	2009	Compared to other central neurones, the unique presence of ASIC3 along with ASIC1a in SCN neurones may contribute to the high pH sensitivity and unusual inhibition by Zn(2+).	Zinc	167-169	acid sensing ion channel subunit 3	Rattus norvegicus	59-64
19475959-5	2009	In a simulation starting with tannin, terpenoid, and flavonoid precursors, metal binding decreases in the order Cu(II) approximately equal to Al(III) approximately equal to Pb(II) &gt; Zn(II) approximately equal to Ni(II) &gt; Ca(II) approximately equal to Cd(II), whereas in simulations containing protein precursors (and thus amine-containing ligands), Al(III) is relatively less and Ni(II) and Cd(II) relatively more strongly bound.	Zinc	185-187	submaxillary gland androgen regulated protein 3B	Homo sapiens	173-179
19204004-5	2009	P2X(7) transfectants survived and even proliferated in serum-free conditions and were resistant to apoptosis triggered by ceramide, staurosporin, or intracellular Zn(2+) chelation.	Zinc	163-165	purinergic receptor P2X 7	Homo sapiens	0-6
19409221-8	2009	Conversely, Zn-weak nuclei, which are more dorsally situated (i.e. dorsal division of lateral nucleus and magnocellular division of basal nucleus) showed only a low level of Abeta deposits, even in brains with the greatest Abeta burden.	Zinc	12-14	amyloid beta precursor protein	Homo sapiens	174-179
19386136-0	2009	Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.	Zinc	14-18	S100 calcium binding protein A12	Homo sapiens	37-44
19301919-6	2009	Interestingly, the Co(II) ions were doped into the Zn(II) complexes, as confirmed by their macroscopical colors, inductively coupled plasma (ICP) analysis and UV-visible spectra.	Zinc	51-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
19282477-8	2009	Basal activity could be dramatically enhanced by the NS3 Zn(2+)-binding domain (NS3 amino acids 81-213) not only in cis but also in trans which, however, required a more extended N-terminal part of NS3 downstream of NS2 in cis.	Zinc	57-63	NS2	Homo sapiens	216-219
18820153-1	2009	Before the discovery and elucidation of transporters, mammals were thought to cotransport Cu or Zn as an anionic complex, such as binding with an AA as a chelate or a receptor such as transferrin.	Zinc	96-98	transferrin	Homo sapiens	184-195
19056730-8	2009	Addition of Zn(II) abolished arsenite enhancement of UVR-stimulated 8-OHdG generation and restored PARP-1 activity.	Zinc	12-18	poly(ADP-ribose) polymerase 1	Homo sapiens	99-105
19135505-0	2009	Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons.	Zinc	14-18	carbonic anhydrase 2	Mus musculus	74-77
19261885-2	2009	Here, we demonstrate that synaptically released Zn(2+) activates a selective postsynaptic Zn(2+)-sensing receptor (ZnR) in the CA3 region of the hippocampus.	Zinc	48-50	carbonic anhydrase 3	Mus musculus	127-130
19083027-3	2009	Zn(II) promotes aggregation of most amyloidogenic peptides/proteins in vitro, including amyloid beta protein (Abeta), but the underlying mechanism is not known.	Zinc	0-6	amyloid beta precursor protein	Homo sapiens	110-115
19083027-7	2009	Further studies by thioflavin T fluorescence spectroscopy, transmission electron microscopy, and circular dichroism (CD) spectroscopy suggested that the aggregates of Zn-Abeta28 formed in 10%TFE contain a beta-sheet secondary structure and are more of the amyloid type.	Zinc	167-169	amyloid beta precursor protein	Homo sapiens	203-209
18816584-5	2009	In this work, we attempted to elucidate the possible mode of interaction between the peptides and ACE, including mechanisms of binding to the cofactor Zn2+, and further contrast this with the known mode of inhibition exerted by synthetic drugs (Captopril, Enalaprilat and Lisinopril).	Zinc	151-155	angiotensin I converting enzyme	Homo sapiens	98-101
19167089-6	2009	Exposing Sp1-3 to micromolar amounts of ebselen resulted in Zn(2+) release from this peptide and the formation of a disulfide bond by oxidation of zinc finger SH groups, the likely mechanism for DNA binding inhibition.	Zinc	60-66	Sp1 transcription factor	Homo sapiens	9-14
19218219-5	2009	Interestingly, it was found that p12 bound both RNA and DNA in vitro, but notably exhibited a preference for DNA in the presence of Zn(2+) ions.	Zinc	132-134	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	33-36
19218219-6	2009	Mutational analysis of the p12 conserved sequence motifs demonstrated that the basic motif is required for p12 translocation to the nucleus, thus representing part of the protein nuclear localization signal, whereas the predicted zinc finger motif is needed for both Zn(2+)-dependent DNA binding and eliciting an HR in PVX-infected leaves.	Zinc	267-273	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	27-30
18816584-7	2009	It was observed that the best docking poses obtained for VPP and IPP were located at the ACE catalytic site with very high resemblance to the drugs mode of interaction, including the coordination with Zn2+.	Zinc	201-205	angiotensin I converting enzyme	Homo sapiens	89-92
19158231-4	2009	administered to rats fed a Zn-Def diet for 3d and food intake was measured.	Zinc	27-29	UTP25 small subunit processome component	Rattus norvegicus	30-33
19141082-4	2009	An Abeta amino acid mutation found in familial AD, Abeta interactions with zinc (Zn), and increased Abeta hydrophobicity all strongly prevented Abeta degradation.	Zinc	81-83	amyloid beta precursor protein	Homo sapiens	3-8
19141082-4	2009	An Abeta amino acid mutation found in familial AD, Abeta interactions with zinc (Zn), and increased Abeta hydrophobicity all strongly prevented Abeta degradation.	Zinc	81-83	amyloid beta precursor protein	Homo sapiens	51-56
19141082-4	2009	An Abeta amino acid mutation found in familial AD, Abeta interactions with zinc (Zn), and increased Abeta hydrophobicity all strongly prevented Abeta degradation.	Zinc	81-83	amyloid beta precursor protein	Homo sapiens	51-56
19141082-4	2009	An Abeta amino acid mutation found in familial AD, Abeta interactions with zinc (Zn), and increased Abeta hydrophobicity all strongly prevented Abeta degradation.	Zinc	81-83	amyloid beta precursor protein	Homo sapiens	51-56
19141082-7	2009	Zn also prevented Abeta degradation by the proteases neprilysin and insulin degrading enzyme.	Zinc	0-2	amyloid beta precursor protein	Homo sapiens	18-23
19141082-7	2009	Zn also prevented Abeta degradation by the proteases neprilysin and insulin degrading enzyme.	Zinc	0-2	membrane metalloendopeptidase	Homo sapiens	53-63
19158231-11	2009	Taken together, orally administered zinc may stimulate food intake via orexigenic peptides coupled to the afferent vagal stimulation in rats after short-term treatment with a Zn-Def diet.	Zinc	175-177	UTP25 small subunit processome component	Rattus norvegicus	178-181
19731816-11	2009	It is also possible to inhibit the aggregation of the beta-amyloid peptide with peptide fragments or with Cu2+ and Zn2+ ion chelators.	Zinc	115-119	amyloid beta precursor protein	Homo sapiens	54-74
19322475-9	2009	(iii) The apparent dissociation constants of Zn(Abeta) in various buffers are in the range of 1 to 20 muM (a 10 times lower conditional dissociation constant can be estimated.	Zinc	45-47	amyloid beta precursor protein	Homo sapiens	48-53
19222791-1	2009	For the first time to our knowledge, X-ray absorption spectroscopy (XAS) has been used to investigate the environment of putative Zn(2+) binding sites in rhodopsin.	Zinc	130-136	rhodopsin	Homo sapiens	154-163
19222791-4	2009	Our results demonstrate that Zn(2+) is intrinsically bound to rhodopsin and are compatible with the existence of an octahedral coordination involving six oxygen atoms in the first shell (average Zn-O distance of 2.08 A), and with a second coordination shell containing one or two phosphorus or sulfur atoms at an average distance of 2.81 A.	Zinc	29-31	rhodopsin	Homo sapiens	62-71
19084674-9	2009	Significantly, different affinities of Pb(2+) and Zn(2+) towards P1- and P2-ISE were found, in good correlation with the higher affinity of these cations towards SpMTA than to MT1.	Zinc	50-52	metallothionein 1	Mus musculus	176-179
19267872-2	2009	Because Zn(2+) binds directly to the photoreceptor rhodopsin and alters its stability, the stabilization of rhodopsin may be key to prevention and treatment of retinal dysfunctions.	Zinc	8-10	rhodopsin	Homo sapiens	51-60
19267872-2	2009	Because Zn(2+) binds directly to the photoreceptor rhodopsin and alters its stability, the stabilization of rhodopsin may be key to prevention and treatment of retinal dysfunctions.	Zinc	8-10	rhodopsin	Homo sapiens	108-117
18951928-5	2009	We show that Zn/PDTC induces p53 proteasomal degradation and that the proteasome inhibitor MG132 further increases fibroblast growth inhibition by Zn/PDTC, suggesting that p53 degradation plays an important role in fibroblast resistance to Zn/PDTC.	Zinc	13-15	tumor protein p53	Homo sapiens	29-32
18951928-5	2009	We show that Zn/PDTC induces p53 proteasomal degradation and that the proteasome inhibitor MG132 further increases fibroblast growth inhibition by Zn/PDTC, suggesting that p53 degradation plays an important role in fibroblast resistance to Zn/PDTC.	Zinc	13-15	tumor protein p53	Homo sapiens	172-175
18951928-5	2009	We show that Zn/PDTC induces p53 proteasomal degradation and that the proteasome inhibitor MG132 further increases fibroblast growth inhibition by Zn/PDTC, suggesting that p53 degradation plays an important role in fibroblast resistance to Zn/PDTC.	Zinc	147-149	tumor protein p53	Homo sapiens	172-175
19459437-6	2009	Cu-Zn SOD and GSH-Px activities were significantly higher in rats fed high-Cr diet, high-Zn and Cr diet, low-Zn diet, and low-Zn and Cr diet when compared to the activities found in the controls.	Zinc	89-91	superoxide dismutase 1	Rattus norvegicus	0-9
19188834-8	2009	Unlike free sulfur of captopril, thiophene ring may act as a free radical scavenger besides chelating the Zn present in the active site of ACE.	Zinc	106-108	angiotensin I converting enzyme	Rattus norvegicus	139-142
21103002-1	2009	We investigate the equilibrium unfolding of Zn-cytochrome c in guanidine hydrochloride by three-pulse photon echo peak shift (3PEPS) spectroscopy.	Zinc	44-46	cytochrome c, somatic	Homo sapiens	47-59
21103002-1	2009	We investigate the equilibrium unfolding of Zn-cytochrome c in guanidine hydrochloride by three-pulse photon echo peak shift (3PEPS) spectroscopy.	Zinc	44-46	leucine aminopeptidase 3	Homo sapiens	127-131
18952458-10	2009	In addition, reactive DESI can be performed with ion/ion reactions of Zn(II) complexes for the selective binding of phosphoserine in the presence of serine.	Zinc	70-76	desumoylating isopeptidase 2	Homo sapiens	22-26
19459437-6	2009	Cu-Zn SOD and GSH-Px activities were significantly higher in rats fed high-Cr diet, high-Zn and Cr diet, low-Zn diet, and low-Zn and Cr diet when compared to the activities found in the controls.	Zinc	89-91	superoxide dismutase 1	Rattus norvegicus	0-9
19459437-8	2009	Also Zn deficiency resulted in increased lipid peroxidation, SOD and GSH-Px activities because of the oxidative stress caused by zinc deficiency.	Zinc	5-7	superoxide dismutase 1	Rattus norvegicus	61-64
19441228-1	2009	The effects of heavy metal cadmium (Cd), alone and in combination with zinc (Zn), on the root growth and activity of antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD) in Cucumis sativus L. hairy roots were studied.	Zinc	77-79	peroxidase 2-like	Cucumis sativus	168-178
19695120-3	2009	This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors.	Zinc	135-141	AKT serine/threonine kinase 1	Homo sapiens	50-53
19695120-3	2009	This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors.	Zinc	135-141	AKT serine/threonine kinase 1	Homo sapiens	191-194
19695120-3	2009	This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors.	Zinc	135-141	AKT serine/threonine kinase 1	Homo sapiens	191-194
19441228-1	2009	The effects of heavy metal cadmium (Cd), alone and in combination with zinc (Zn), on the root growth and activity of antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD) in Cucumis sativus L. hairy roots were studied.	Zinc	77-79	peroxidase 2-like	Cucumis sativus	180-183
19441228-11	2009	After 5 days culture with different concentrations of Cd + 25 mg/L Zn, the root biomass and the activity of POD and SOD were lower than in C. sativus hairy roots cultured without the addition of Zn.	Zinc	67-69	peroxidase 2-like	Cucumis sativus	108-111
18809628-3	2008	RESULTS: Zn intake correlated with osteocalcin in the group overall (r = 0.48; P &lt; 0.001) but not with N-telopeptides.	Zinc	9-11	bone gamma-carboxyglutamate protein	Homo sapiens	35-46
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	integrin linked kinase	Homo sapiens	47-50
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	integrin linked kinase	Homo sapiens	123-126
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	LIM homeobox 1	Homo sapiens	328-332
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	integrin linked kinase	Homo sapiens	123-126
18848528-2	2008	Both Zn2+ and Cu2+ potently inhibit rat P2X7 receptors via a binding site identified by mutagenesis.	Zinc	5-9	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	40-44
18848528-4	2008	By contrast, the receptor expression system and agonist strongly influence the action of extracellular Zn2+ at mouse P2X7 receptors.	Zinc	103-107	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	117-121
18848528-5	2008	Consistent with previous reports, Zn2+ inhibits recombinant rat P2X7 receptors.	Zinc	34-38	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	64-68
18848528-6	2008	However, recombinant mouse P2X7 receptors are potentiated by Zn2+ when activated by ATP4- but inhibited when stimulated with the ATP analogue BzATP4-.	Zinc	61-65	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	27-31
18848528-7	2008	Endogenous murine macrophage P2X7 receptors are not modulated by Zn2+ when stimulated by ATP4- however Zn2+ inhibits BzATP4- mediated responses.	Zinc	103-107	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	29-33
18848528-8	2008	In summary, these findings provide a fundamental insight into the differential actions of Zn2+ and Cu2+ between different P2X7 receptor species.	Zinc	90-94	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	122-135
18809628-8	2008	Zn intake (P &lt; 0.001), however, was the only independent correlate of osteocalcin.	Zinc	0-2	bone gamma-carboxyglutamate protein	Homo sapiens	73-84
18809628-9	2008	CONCLUSIONS: This study provides evidence of a positive relationship between Zn intake and osteocalcin in type 1 diabetes.	Zinc	77-79	bone gamma-carboxyglutamate protein	Homo sapiens	91-102
19256393-4	2008	The Zn concentration classes estimated by CART have accuracy in attribution to the right classes of 80.49%.	Zinc	4-6	CART prepropeptide	Homo sapiens	42-46
19256393-7	2008	Moreover, CART provided some insights into the sources of current soil Zn contents.	Zinc	71-73	CART prepropeptide	Homo sapiens	10-14
18618364-1	2008	The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes.	Zinc	243-249	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
18838534-2	2008	We have established a genetically defined differentiation model in human leukemia K562 cells by conditional expression of the cyclin-dependent kinase (Cdk) inhibitor p27 (inducible by Zn(2+)) and Myc (activatable by 4-hydroxy-tamoxifen).	Zinc	184-186	zinc ribbon domain containing 2	Homo sapiens	166-169
18997297-3	2008	Based on in vivo studies that show animals provided a zinc (Zn) deficient diet demonstrate decreased brain ZnT-1, we used inductively coupled plasma-mass spectrometry (ICP-MS) to quantify serum Zn levels from 18 living mild to moderate AD patients (9 men, 9 women), 19 MCI patients (9 men, 10 women) and 16 age-matched normal control (NC) subjects (9 men, 7 women).	Zinc	60-62	solute carrier family 30 member 1	Homo sapiens	107-112
18725203-1	2008	Insulin is stored in pancreatic beta-cell as hexameric form with Zn2+ ions, while the hormonally active form is monomer.	Zinc	65-69	insulin	Homo sapiens	0-7
18725203-3	2008	In order to reveal the mechanism of the hexamerization of insulin, we investigated the Zn2+ free insulin at pD6.6 and pD9 by neutron crystallographic analyses.	Zinc	87-91	insulin	Homo sapiens	58-65
18725203-3	2008	In order to reveal the mechanism of the hexamerization of insulin, we investigated the Zn2+ free insulin at pD6.6 and pD9 by neutron crystallographic analyses.	Zinc	87-91	insulin	Homo sapiens	97-104
18308622-1	2008	Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of salicylidene-N-cyano-acetohydrazone H2L1 and 2-hydroxy-l-naphthylidene-N-cyanoacetohydrazone H2L2 have been prepared in ethanolic solution and characterized by analytical, spectral, magnetic susceptibility, molar conductivity and TGA measurements.	Zinc	35-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
18815222-6	2008	MT-1 overexpression correlated with a steady-state increase in cytoplasmic free Zn(2+), assessed using the fluorescent zinc-sensor Zinquin, particularly at high levels of overexpression, further suggesting that zinc availability is normally not limiting for cell cycle progression.	Zinc	80-82	metallothionein 1	Mus musculus	0-4
18815222-7	2008	Enhanced MT-1 expression, over a 10-fold range, had a clear impact on resistance to Cd(2+) and Zn(2+) toxicity.	Zinc	95-97	metallothionein 1	Mus musculus	9-13
18815222-8	2008	In the case of Zn(2+), the degree of protection afforded was less, indicating that MT-1 has a limited range and saturable capacity for effecting resistance.	Zinc	15-17	metallothionein 1	Mus musculus	83-87
18826240-5	2008	Each metalation state of the reconstituted SOD-1 could be unambiguously differentiated by electrospray ionization mass spectrometry, the metal ions of which had been completely replaced by 99 atom % (63)Cu and (68)Zn stable isotopes.	Zinc	214-216	superoxide dismutase 1	Homo sapiens	43-48
18997297-7	2008	Overall, these data suggest a significant decrease of serum Zn in men with MCI, may explain the loss of ZnT-1 observed in previous studies and suggest there may be more pronounced sex differences in MCI than were previously recognized.	Zinc	60-62	solute carrier family 30 member 1	Homo sapiens	104-109
18936212-6	2008	Differences in pancreatic data in MT-/- were explained by Zn turning over twice as fast in this tissue (4 h) compared with wild type (9 h).	Zinc	58-60	metallothionein 2	Mus musculus	34-39
18809082-16	2008	As part of the method validation the relative stability of complexes of albumin, transferrin and citrate with Mn, Fe, Cu and Zn was investigated.	Zinc	125-127	transferrin	Homo sapiens	81-92
18602402-3	2008	In the presence and absence of Zn(2+), electron density corresponding to two Pnt molecules per S100B subunit was mapped for both drug-bound structures.	Zinc	31-33	S100 calcium binding protein B	Homo sapiens	95-100
18602402-5	2008	In addition, a conformational change in S100B was observed upon the addition of Zn(2+) to Ca(2+)-S100B, which changed the conformation and orientation of Pnt bound to sites 1 and 2 of Pnt-Zn(2+),Ca(2+)-S100B when compared to Pnt-Ca(2+)-S100B.	Zinc	80-82	S100 calcium binding protein B	Homo sapiens	40-45
18602402-5	2008	In addition, a conformational change in S100B was observed upon the addition of Zn(2+) to Ca(2+)-S100B, which changed the conformation and orientation of Pnt bound to sites 1 and 2 of Pnt-Zn(2+),Ca(2+)-S100B when compared to Pnt-Ca(2+)-S100B.	Zinc	80-82	S100 calcium binding protein B	Homo sapiens	97-102
18602402-5	2008	In addition, a conformational change in S100B was observed upon the addition of Zn(2+) to Ca(2+)-S100B, which changed the conformation and orientation of Pnt bound to sites 1 and 2 of Pnt-Zn(2+),Ca(2+)-S100B when compared to Pnt-Ca(2+)-S100B.	Zinc	80-82	S100 calcium binding protein B	Homo sapiens	97-102
18602402-5	2008	In addition, a conformational change in S100B was observed upon the addition of Zn(2+) to Ca(2+)-S100B, which changed the conformation and orientation of Pnt bound to sites 1 and 2 of Pnt-Zn(2+),Ca(2+)-S100B when compared to Pnt-Ca(2+)-S100B.	Zinc	80-82	S100 calcium binding protein B	Homo sapiens	97-102
18602402-6	2008	That Pnt can adapt to this Zn(2+)-dependent conformational change was unexpected and provides a new mode for S100B inhibition by this drug.	Zinc	27-33	S100 calcium binding protein B	Homo sapiens	109-114
18602402-7	2008	These data will be useful for developing novel inhibitors of both Ca(2+)- and Ca(2+),Zn(2+)-bound S100B.	Zinc	85-91	S100 calcium binding protein B	Homo sapiens	98-103
18758443-4	2008	The AMSH-LP DUB domain consists of a Zn(2+)-coordinating catalytic core and two characteristic insertions, Ins-1 and Ins-2.	Zinc	37-39	STAM binding protein like 1	Homo sapiens	4-11
18513776-3	2008	In this study, we characterized the transcriptional and posttranscriptional events that regulate COX-2 expression in a human bronchial epithelial cell line BEAS-2B exposed to Zn2+.	Zinc	175-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	peroxiredoxin 4	Sus scrofa	135-140
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	carboxypeptidase B2	Sus scrofa	154-158
18463798-0	2008	Promotion of Zn(2+) uptake by Al (3+) in a Saccharomyces Cerevisiae mutant that lacks the ZRT1 gene encoding a high-affinity Zn transporter.	Zinc	13-19	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	90-94
18463798-1	2008	A Saccharomyces cerevisiae mutant (zrt1Delta) lacking the ZRT1 gene, which encodes a high-affinity Zn(2+) transporter, scarcely thrived in a low-pH, low-phosphate medium because of Zn(2+) deficiency.	Zinc	99-101	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	58-62
17964848-0	2008	Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-alpha-aminobutyric acid.	Zinc	61-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
18513776-4	2008	Zn2+ exposure resulted in pronounced increases in COX-2 mRNA and protein expression, which were prevented by pretreatment with the transcription inhibitor actinomycin D, implying the involvement of transcriptional regulation.	Zinc	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
18513776-5	2008	This was supported by the observation of increased COX-2 promoter activity in Zn2+-treated BEAS-2B cells.	Zinc	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
18513776-6	2008	Mutation of the cAMP response element (CRE), but not the kappaB-binding sites in the COX-2 promoter markedly reduced COX-2 promoter activity induced by Zn2+.	Zinc	152-156	cathelicidin antimicrobial peptide	Homo sapiens	16-20
18513776-6	2008	Mutation of the cAMP response element (CRE), but not the kappaB-binding sites in the COX-2 promoter markedly reduced COX-2 promoter activity induced by Zn2+.	Zinc	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
18513776-6	2008	Mutation of the cAMP response element (CRE), but not the kappaB-binding sites in the COX-2 promoter markedly reduced COX-2 promoter activity induced by Zn2+.	Zinc	152-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122
18513776-8	2008	Measurement of mRNA stability demonstrated that Zn2+ exposure impaired the degradation of COX-2 mRNA in BEAS-2B cells.	Zinc	48-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
18513776-9	2008	This message stabilization effect of Zn2+ exposure was shown to be dependent on the integrity of the 3"-untranslated region found in the COX-2 transcript.	Zinc	37-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
18513776-10	2008	Taken together, these data demonstrate that the CRE and mRNA stability regulates COX-2 expression induced in BEAS-2B cells exposed to extracellular Zn2+.	Zinc	148-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
18711142-0	2008	Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.	Zinc	69-73	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	28-31
18711142-2	2008	Here, we report that micromolar concentrations of the divalent cation Zn(2+) produce a 10-fold potentiation of NR1/NR3A receptor responses, which resembles that seen upon antagonizing glycine binding to the NR1 subunit.	Zinc	70-72	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	111-114
18711142-2	2008	Here, we report that micromolar concentrations of the divalent cation Zn(2+) produce a 10-fold potentiation of NR1/NR3A receptor responses, which resembles that seen upon antagonizing glycine binding to the NR1 subunit.	Zinc	70-72	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	207-210
18711142-3	2008	Coapplication of both Zn(2+) and NR1 antagonist caused a supralinear potentiation, resulting in a &gt;120-fold increase of glycine-activated currents.	Zinc	22-24	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	33-36
18711142-5	2008	Point mutations in the NR1 and NR3A glycine-binding sites revealed that both the potentiating and agonistic effects of Zn(2+) are mediated by the ligand-binding domain of the NR1 subunit.	Zinc	119-121	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	23-26
18711142-5	2008	Point mutations in the NR1 and NR3A glycine-binding sites revealed that both the potentiating and agonistic effects of Zn(2+) are mediated by the ligand-binding domain of the NR1 subunit.	Zinc	119-121	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	175-178
18711142-6	2008	In conclusion, Zn(2+) acts as a potent positive modulator and agonist at the NR1 subunit of NR1/NR3A receptors.	Zinc	15-17	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	77-80
18711142-6	2008	In conclusion, Zn(2+) acts as a potent positive modulator and agonist at the NR1 subunit of NR1/NR3A receptors.	Zinc	15-17	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	92-95
18242833-6	2008	The maximum sorption obtained for (PR) and (APR) is between pH 2 and 3 for Pb(2+) and 4 and 6 for Cd(2+), Cu(2+) and Zn(2+).	Zinc	117-119	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	44-47
18242833-9	2008	They show that sorption of Pb(2+), Cd(2+), Cu(2+) and Zn(2+) on (PR) and (APR) an endothermic process.	Zinc	54-56	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	74-77
18669660-1	2008	FRET between the zinc porphyrin (ZnP) chromophore in zinc-substituted cytochrome c (Zn-cyt c) and an Alexa Fluor dye attached to specific surface sites was used to characterize Zn-cyt c unfolding.	Zinc	33-35	cytochrome c, somatic	Homo sapiens	70-82
18669660-1	2008	FRET between the zinc porphyrin (ZnP) chromophore in zinc-substituted cytochrome c (Zn-cyt c) and an Alexa Fluor dye attached to specific surface sites was used to characterize Zn-cyt c unfolding.	Zinc	84-86	cytochrome c, somatic	Homo sapiens	70-82
18397814-5	2008	On addition of Zn(2+) to form M-DNA the C 1s, P 2p and S 2p showed only small changes while both the N 1s and O 1s spectra changed considerably.	Zinc	15-17	complement C1s	Homo sapiens	40-44
18397814-5	2008	On addition of Zn(2+) to form M-DNA the C 1s, P 2p and S 2p showed only small changes while both the N 1s and O 1s spectra changed considerably.	Zinc	15-17	pyrimidinergic receptor P2Y4	Homo sapiens	46-50
18397814-5	2008	On addition of Zn(2+) to form M-DNA the C 1s, P 2p and S 2p showed only small changes while both the N 1s and O 1s spectra changed considerably.	Zinc	15-17	proteasome 26S subunit ubiquitin receptor, non-ATPase 2	Homo sapiens	55-59
18694310-4	2008	These two scFv mutants were conjugated directly with CdSe/ZnS Qdots and their binding activities were measured and compared.	Zinc	58-61	immunglobulin heavy chain variable region	Homo sapiens	10-14
18694310-5	2008	RESULTS &amp; DISCUSSION: Both scFv mutants can be conjugated covalently with CdSe/ZnS Qdots; however, the resulting conjugates exhibit significantly different affinities in the prostate-specific antigen fluoroimmunoassays--the binding activity of scFvB80-M2/Qdots is equivalent of that of free scFvB80 and four times of that of scFvB80-M1/Qdots.	Zinc	83-86	immunglobulin heavy chain variable region	Homo sapiens	31-35
18598056-2	2008	Currently, there is a long-standing dispute regarding the role of Abeta-metal ion (Zn, Cu, and Fe) complexes in AD pathogenesis.	Zinc	83-85	amyloid beta precursor protein	Homo sapiens	66-71
18563879-0	2008	Mechanism of single metal exchange in the reactions of [M4(SPh)10]2- (M = Zn or Fe) with CoX2 (X = Cl or NO3) or FeCl2.	Zinc	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-93
18570397-1	2008	Due in large part to the lack of crystal structures of the amyloid-beta (Abeta) peptide and its complexes with Cu(II), Fe(II), and Zn(II), characterization of the metal-Abeta complex has been difficult.	Zinc	131-137	amyloid beta precursor protein	Homo sapiens	73-78
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Zinc	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	199-205
18445468-5	2008	The described refolding strategy can be used to prepare other Co(II)-substituted Zn(II)-metalloenzymes, particularly those that contain a solvent-exposable disulfide, which often causes oxidation of Co(II) to Co(III).	Zinc	81-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	209-216
18614028-1	2008	As a disease-modifying approach for Alzheimer"s disease (AD), clioquinol (CQ) targets beta-amyloid (Abeta) reactions with synaptic Zn and Cu yet promotes metal uptake.	Zinc	131-133	histocompatibility 2, class II antigen A, beta 1	Mus musculus	100-105
18482984-13	2008	Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity.	Zinc	59-63	kallikrein related peptidase 14	Homo sapiens	39-44
18482984-13	2008	Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity.	Zinc	59-63	kallikrein related peptidase 14	Homo sapiens	108-113
18645413-1	2008	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of 2 homologous domains, each bearing a Zn-dependent active site.	Zinc	136-138	angiotensin I converting enzyme	Homo sapiens	0-31
18529053-0	2008	Monomethylarsenite competes with Zn2+ for binding sites in the glucocorticoid receptor.	Zinc	33-37	nuclear receptor subfamily 3 group C member 1	Homo sapiens	63-86
18529053-1	2008	The binding of arsenite (As(III)) and monomethylarsenite (MMAIII) to the DNA-binding domain of the glucocorticoid receptor (GR-DBD) and their competition with the two required Zn2+ ions of this domain have been investigated with isothermal titration calorimetry (ITC) and circular dichroism (CD).	Zinc	176-180	nuclear receptor subfamily 3 group C member 1	Homo sapiens	99-122
18645413-1	2008	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of 2 homologous domains, each bearing a Zn-dependent active site.	Zinc	136-138	angiotensin I converting enzyme	Homo sapiens	33-36
20126369-8	2008	The results showed that in in vitro study, Zn-adequate group induced more VCAM-1 &amp; ICAM-1 mRNA expression than Zn-deficient group during 6-hour zinc treatment post-5 hour TNF-alpha treatment, unexpectedly.	Zinc	43-45	tumor necrosis factor	Mus musculus	175-184
18270806-10	2008	Zn-doped TCP exhibited good bioactivity, which enhanced cell differentiation and alkaline phosphatase (ALP) expression.	Zinc	0-2	alkaline phosphatase, placental	Homo sapiens	81-101
18270806-10	2008	Zn-doped TCP exhibited good bioactivity, which enhanced cell differentiation and alkaline phosphatase (ALP) expression.	Zinc	0-2	alkaline phosphatase, placental	Homo sapiens	103-106
18270806-11	2008	The highest cell proliferation and ALP expression were found on dual Mg and Zn doped TCP.	Zinc	76-78	alkaline phosphatase, placental	Homo sapiens	35-38
17566863-5	2008	The samples from IS1, IS2, and IS3, located in the Talcahuano industrial park, had higher Cr, Ni, Pb, and Zn contents than did samples from the other sites.	Zinc	106-108	IS2	Homo sapiens	22-25
18588663-5	2008	RESULTS: Constitutive expression of the stronger interactor, Dpy-30L1 (CG6444), in transgenic flies inhibits MTF-1 activity and results in elevated sensitivity to Cd(II) and Zn(II), an effect that could be rescued by co-overexpression of dMTF-1.	Zinc	174-180	Dpy-30-like 1	Drosophila melanogaster	61-69
18481845-3	2008	Potentiometric titrations of HL1 in the presence of Ni2+ and Zn2+ reveal formation of species with a metal:ligand ratio 1:1 in aqueous solution, and UV-vis data for the NiII system suggest that the complex [L12Ni2]2+ with (NiN6) chromophore is formed under appropriate pH conditions.	Zinc	61-65	asialoglycoprotein receptor 1	Homo sapiens	29-32
18574758-6	2008	Terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL) staining showed that exposure to 100microM Zn(2+) significantly increased the number of pro-apoptotic neurons in cultures maintained with BDNF, while these conditions had no effect on cultures maintained with CNTF.	Zinc	134-136	DNA nucleotidylexotransferase	Rattus norvegicus	0-37
18574758-6	2008	Terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL) staining showed that exposure to 100microM Zn(2+) significantly increased the number of pro-apoptotic neurons in cultures maintained with BDNF, while these conditions had no effect on cultures maintained with CNTF.	Zinc	134-136	ciliary neurotrophic factor	Rattus norvegicus	300-304
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	135-137	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	68-72
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	161-163	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	68-72
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	cell adhesion molecule 1	Homo sapiens	32-35
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	phosphodiesterase 5A	Homo sapiens	54-58
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	cell adhesion molecule 1	Homo sapiens	59-62
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	phosphodiesterase 5A	Homo sapiens	175-179
18161687-3	2008	It has been shown that, whereas BL2 (i.e. HO-) in the PDE5(BL2 = HO-) structure can really bridge the two positively charged metal ions (Zn2+ and Mg2+), BL2 (i.e. H2O) in the PDE5(BL2 = H2O) structure can only coordinate Mg2+.	Zinc	137-141	cell adhesion molecule 1	Homo sapiens	59-62
18493004-9	2008	Moreover, the mRNA levels of metallothionein, zinc transporter 1, and Zn transporter 5 were lower in the ileum than in the duodenum or jejunum in the Zn-supplemented group, further indicating that Zn absorption in the ileum occurred mainly by a nonsaturable diffusive pathway.	Zinc	150-152	solute carrier family 30 member 1	Homo sapiens	46-64
18359862-1	2008	We have studied the binding of Zn2+ to the hexa EF-hand protein, calbindin D(28k)-a strong Ca2+-binder involved in apoptosis regulation-which is highly expressed in brain tissue.	Zinc	31-35	centrin 1	Homo sapiens	48-63
18646527-0	2008	[Effect of Zn2+ on level of IL-8 and TNF-alpha mRNA and protein expressed of human II alveolar epithelial cells].	Zinc	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18646527-0	2008	[Effect of Zn2+ on level of IL-8 and TNF-alpha mRNA and protein expressed of human II alveolar epithelial cells].	Zinc	11-15	tumor necrosis factor	Homo sapiens	37-46
18646527-1	2008	OBJECTIVE: To study the effect of Zn2+ on levels of the cytokines IL-8 and TNF-alpha mRNA expression of human II alveolar epithelial cell.	Zinc	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
18646527-1	2008	OBJECTIVE: To study the effect of Zn2+ on levels of the cytokines IL-8 and TNF-alpha mRNA expression of human II alveolar epithelial cell.	Zinc	34-38	tumor necrosis factor	Homo sapiens	75-84
18646527-3	2008	RESULTS: Incubation of A549 cells with Zn2+ for 3 h and 24h could stimulate the accumulations of IL-8 and TNF-alpha mRNA and protein of A549 cells in a concentration-dependent manner.	Zinc	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18646527-3	2008	RESULTS: Incubation of A549 cells with Zn2+ for 3 h and 24h could stimulate the accumulations of IL-8 and TNF-alpha mRNA and protein of A549 cells in a concentration-dependent manner.	Zinc	39-43	tumor necrosis factor	Homo sapiens	106-115
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	96-100	tumor necrosis factor	Homo sapiens	39-48
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	173-177	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	173-177	tumor necrosis factor	Homo sapiens	39-48
18348525-0	2008	Mechanism of intramolecular electron transfer in the photoexcited Zn-substituted cytochrome c: theoretical and experimental perspective.	Zinc	66-68	cytochrome c, somatic	Homo sapiens	81-93
18262489-6	2008	Long-term exposure of BHMT to reducing agent-free buffer results in the slow, irreversible loss of its catalytic Zn and a corresponding loss of activity.	Zinc	113-115	betaine-homocysteine methyltransferase	Mus musculus	22-26
18201802-1	2008	It has been recently proposed that the second extracellular loop of the human bradykinin (BK) B1 receptor (B1R) contains a conserved HExxH motif also present in peptidases possessing a Zn2+ prosthetic group, such as angiotensin converting enzyme (ACE), and that ACE inhibitors directly activate B1R signaling in endothelial cells.	Zinc	185-189	bradykinin receptor B1	Homo sapiens	107-110
18201802-1	2008	It has been recently proposed that the second extracellular loop of the human bradykinin (BK) B1 receptor (B1R) contains a conserved HExxH motif also present in peptidases possessing a Zn2+ prosthetic group, such as angiotensin converting enzyme (ACE), and that ACE inhibitors directly activate B1R signaling in endothelial cells.	Zinc	185-189	angiotensin I converting enzyme	Homo sapiens	216-245
18201802-1	2008	It has been recently proposed that the second extracellular loop of the human bradykinin (BK) B1 receptor (B1R) contains a conserved HExxH motif also present in peptidases possessing a Zn2+ prosthetic group, such as angiotensin converting enzyme (ACE), and that ACE inhibitors directly activate B1R signaling in endothelial cells.	Zinc	185-189	angiotensin I converting enzyme	Homo sapiens	247-250
18201802-1	2008	It has been recently proposed that the second extracellular loop of the human bradykinin (BK) B1 receptor (B1R) contains a conserved HExxH motif also present in peptidases possessing a Zn2+ prosthetic group, such as angiotensin converting enzyme (ACE), and that ACE inhibitors directly activate B1R signaling in endothelial cells.	Zinc	185-189	angiotensin I converting enzyme	Homo sapiens	262-265
18201802-1	2008	It has been recently proposed that the second extracellular loop of the human bradykinin (BK) B1 receptor (B1R) contains a conserved HExxH motif also present in peptidases possessing a Zn2+ prosthetic group, such as angiotensin converting enzyme (ACE), and that ACE inhibitors directly activate B1R signaling in endothelial cells.	Zinc	185-189	bradykinin receptor B1	Homo sapiens	295-298
18267353-2	2008	IL-6 SNP at position -174 is associated with age-related diseases characterized by an impaired Zn status.	Zinc	95-97	interleukin 6	Homo sapiens	0-4
18508497-4	2008	The proper intracellular Zn2+ level maintains the fragmentation of DNA associated with caspase-3 activity.	Zinc	25-29	caspase 3	Homo sapiens	87-96
18619328-0	2008	[Bovine serum albumin in the presence of zinc (II) by fluorescence method].	Zinc	41-50	albumin	Homo sapiens	14-21
18619328-1	2008	The interaction between norfloxacin and bovine serum albumin, and the influence of Zinc (II) on the system of norfloxacin and bovine serum albumin was studied under physiological condition by fluorescence method.	Zinc	83-92	albumin	Homo sapiens	139-146
18272141-8	2008	Zinc treatment (100 microM Zn) reduced zinc uptake under resting, but not depolarizing conditions, which was associated with lower plasma membrane-associated and total Zip6 protein abundance.	Zinc	27-29	solute carrier family 39 member 6	Homo sapiens	168-172
18272178-2	2008	Disease-related antigenic epitopes are mainly found in the coiled-coil domain of Ro52, but one such epitope is located in the Zn(2+)-binding region, which comprises an N-terminal RING followed by a B-box, separated by a approximately 40-residue linker peptide.	Zinc	126-128	tripartite motif containing 21	Homo sapiens	81-85
18272178-8	2008	Recombinant Ro52 RING-RBL exists as a monomer in vitro, and binding of two Zn(2+) increases its stability.	Zinc	75-77	tripartite motif containing 21	Homo sapiens	12-16
17618107-11	2008	Moderate Zn restriction led to greater leukocyte infiltration in the LP after the LPS challenge (P&lt;.05) and higher plasma IL-6 and IL-10 levels 24 h after the LPS challenge (P&lt;.01).	Zinc	9-11	interleukin 6	Mus musculus	125-129
18155948-5	2008	Zn(2+), Mg(2+) and Mn(2+) all showed bi-modal effects on LAP activity (activated at low concentrations and inhibited at high concentrations).	Zinc	0-6	leucine aminopeptidase 3	Homo sapiens	57-60
18289347-1	2008	There is evidence that binding of metal ions like Zn2+ and Cu2+ to amyloid beta-peptides (Abeta) may contribute to the pathogenesis of Alzheimer"s disease.	Zinc	50-54	amyloid beta precursor protein	Homo sapiens	90-95
18289347-2	2008	Cu2+ and Zn2+ form complexes with Abeta peptides in vitro; however, the published metal-binding affinities of Abeta vary in an enormously large range.	Zinc	9-13	amyloid beta precursor protein	Homo sapiens	34-39
18289347-2	2008	Cu2+ and Zn2+ form complexes with Abeta peptides in vitro; however, the published metal-binding affinities of Abeta vary in an enormously large range.	Zinc	9-13	amyloid beta precursor protein	Homo sapiens	110-115
18289347-3	2008	We studied the interactions of Cu2+ and Zn2+ with monomeric Abeta(40) under different conditions using intrinsic Abeta fluorescence and metal-selective fluorescent dyes.	Zinc	40-44	amyloid beta precursor protein	Homo sapiens	60-65
18289347-8	2008	Interaction of both Zn2+ and Cu2+ ions with Abeta peptides may occur in brain areas affected by Alzheimer"s disease and Zn2+-induced transition in the peptide structure might contribute to amyloid plaque formation.	Zinc	20-24	amyloid beta precursor protein	Homo sapiens	44-49
18289347-8	2008	Interaction of both Zn2+ and Cu2+ ions with Abeta peptides may occur in brain areas affected by Alzheimer"s disease and Zn2+-induced transition in the peptide structure might contribute to amyloid plaque formation.	Zinc	120-124	amyloid beta precursor protein	Homo sapiens	44-49
17618107-11	2008	Moderate Zn restriction led to greater leukocyte infiltration in the LP after the LPS challenge (P&lt;.05) and higher plasma IL-6 and IL-10 levels 24 h after the LPS challenge (P&lt;.01).	Zinc	9-11	interleukin 10	Mus musculus	134-139
18171027-2	2008	DDAH-1 is a Zn(II)-containing enzyme that through hydrolysis of methylated l-arginines regulates the activity of NOS.	Zinc	12-18	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	0-6
18214943-8	2008	Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell.	Zinc	0-2	interleukin 6	Homo sapiens	86-90
18214943-8	2008	Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell.	Zinc	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18214943-8	2008	Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell.	Zinc	0-2	interleukin 2	Homo sapiens	164-168
17870174-1	2008	Synthesis and crystal structure of two Zn(II) dimer complexes with 1-methylcytosine (1-MeC) are reported.	Zinc	39-45	C-C motif chemokine ligand 28	Homo sapiens	87-90
17870174-3	2008	In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands.	Zinc	4-9	C-C motif chemokine ligand 28	Homo sapiens	12-15
17870174-3	2008	In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands.	Zinc	4-9	C-C motif chemokine ligand 28	Homo sapiens	92-95
18048453-3	2008	Zn(2+) inhibits NMDA receptors containing the NR2A subunit with an IC(50) value in the low nanomolar concentration range.	Zinc	0-6	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	46-50
18077134-3	2008	We determined whether a Zn supplementation, which increases serum Zn concentration and Zn exchangeable pool mass, modifies whole-body protein turnover and albumin and fibrinogen synthesis rates in late-middle-aged men.	Zinc	24-26	fibrinogen beta chain	Homo sapiens	167-177
17499651-2	2008	Using hydrophobic CdSe/ZnS quantum dots (QD), we found that QD-loaded VIP-SSMM accumulated significantly faster and in greater quantity in MCF-7 cells than did QD-loaded SSMM alone (p&lt;0.05).	Zinc	23-26	vasoactive intestinal peptide	Homo sapiens	70-73
18048007-6	2008	Moreover, Zn2+, an NR2A-NMDA-R antagonist, also reduced NMDA-mediated mEPSCs and glycine with Zn2+ enhanced the NMDA-mediated mEPSCs.	Zinc	10-14	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	19-23
17890387-2	2008	External Zn(2+) determines a potentiation of the current mediated by the dimeric construct KDC1-KAT1, which has been ascribed to zinc binding at a site comprising three histidines located at the S3-S4 (H161, H162) and S5-S6 (H224) linkers of KDC1.	Zinc	9-11	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	96-100
17890387-6	2008	Kinetic modeling shows that Zn(2+) slows the closing kinetics of KDC1-KAT1 without affecting the opening kinetics.	Zinc	28-30	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	70-74
18184566-2	2008	In NMDA receptors (NMDARs), the NTDs of NR2A and NR2B subunits also form binding sites for the endogenous inhibitor Zn(2+) ion.	Zinc	116-118	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	40-44
18054826-5	2008	The zinc (Zn) concentration increased significantly in the intestinal cytosol and plasma during the time the mice were fed the low-Ca diet, and expression of both MT-1 and ZnT-1 sharply increased with a similar time course.	Zinc	10-12	metallothionein 1	Mus musculus	163-167
18311544-0	2008	High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.	Zinc	19-23	dual specificity phosphatase 3	Homo sapiens	42-45
18311544-0	2008	High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.	Zinc	19-23	mitogen-activated protein kinase 1	Homo sapiens	58-61
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Zinc	72-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	263-269
18956402-2	2008	Co-grinding of the metal acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with CNacacH formed a CNacac complex in all cases: mononuclear complex was formed in the cases of Mn(II), Cu(II) and Zn(II), whereas polymeric ones were formed in the cases of Fe(II), Co(II) and Ni(II).	Zinc	196-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-51
18688837-10	2008	These results indicate that Pb(II), the most active metal ion, competes for Tb(III) binding differently from other metal ions such as Zn(II), suggesting that Pb(II) may bind to a different site from that for the other metal ions including Zn(II) and Tb(III).	Zinc	134-136	submaxillary gland androgen regulated protein 3B	Homo sapiens	158-164
18688837-10	2008	These results indicate that Pb(II), the most active metal ion, competes for Tb(III) binding differently from other metal ions such as Zn(II), suggesting that Pb(II) may bind to a different site from that for the other metal ions including Zn(II) and Tb(III).	Zinc	239-241	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
18688837-10	2008	These results indicate that Pb(II), the most active metal ion, competes for Tb(III) binding differently from other metal ions such as Zn(II), suggesting that Pb(II) may bind to a different site from that for the other metal ions including Zn(II) and Tb(III).	Zinc	239-241	submaxillary gland androgen regulated protein 3B	Homo sapiens	158-164
17955552-4	2008	Both the intraneuronal Zn(2+) release and the K(+) current surge could be prevented by the NADPH oxidase inhibitor apocynin, the free radical scavenging mixture of superoxide dismutase and catalase, as well as by 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride.	Zinc	23-25	catalase	Homo sapiens	189-197
17935775-3	2008	Bioinformatics predicts that CIAPIN1 may contain a generic methyltransferase motif and a Zn-ribbon-like motif.	Zinc	89-91	cytokine induced apoptosis inhibitor 1	Homo sapiens	29-36
18346929-4	2008	In addition to its cognate ligands, the epidermal growth factor receptor can be activated by metals such as zinc (Zn) and copper (Cu).	Zinc	114-116	epidermal growth factor receptor	Homo sapiens	40-72
18071845-7	2008	Metal ions (Zn2+ and Al3+) inhibited the reaction of peroxidase with p-coumarate and affected the cooxidation rate of ascorbate and the peroxidase reaction in the same manner with all substrates used.	Zinc	12-16	peroxidase	Glycine max	53-63
17870174-3	2008	In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands.	Zinc	4-6	C-C motif chemokine ligand 28	Homo sapiens	12-15
17870174-3	2008	In [Zn(2)(1-MeC-N3)(4)(mu-SO(4))(2)].2H(2)O (2), the sulfates act as bridging ligands and 1-MeC are linked via N3 to Zn(II) as terminal ligands.	Zinc	4-6	C-C motif chemokine ligand 28	Homo sapiens	92-95
18071845-7	2008	Metal ions (Zn2+ and Al3+) inhibited the reaction of peroxidase with p-coumarate and affected the cooxidation rate of ascorbate and the peroxidase reaction in the same manner with all substrates used.	Zinc	12-16	peroxidase	Glycine max	136-146
18309546-1	2007	Zn-deficient (ZD) rats have a lower proportion of splenic CD90+T-cells which could be due to fewer new T-cells exiting the thymus, defective post-thymic maturation or increased cell death.	Zinc	0-2	Thy-1 cell surface antigen	Rattus norvegicus	58-62
17600337-1	2007	Transferrin and mouse anti-human CD71 monoclonal antibody were respectively conjugated covalently to the core/shell CdSe/ZnS quantum dots with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydrocylsulfo-succinimide (Sulfo-NHS).	Zinc	121-124	transferrin	Homo sapiens	0-11
18712494-2	2008	Its biological effects are most likely ascribed to complexation of specific metal ions, such as copper (II) and zinc (II), critically associated with beta-amyloid (A beta) aggregation/fibrillogenesis and degeneration processes in the brain.	Zinc	112-121	amyloid beta precursor protein	Homo sapiens	164-170
18712494-3	2008	The present study was aimed at assessing the in vitro effects of CQ on the aggregation/fibrillogenesis properties of human A beta either alone or complexed with Cu(2+) and Zn(2+).	Zinc	172-174	amyloid beta precursor protein	Homo sapiens	123-129
18221229-3	2007	The amyloid beta (Abeta) peptide and its parental molecule, the amyloid precursor protein (APP) both modulate Cu and Zn metabolism in the brain.	Zinc	117-119	amyloid beta precursor protein	Homo sapiens	4-16
17671992-6	2007	The NMDA (10 microM) response was blocked by 1 nM Zn(2+) and 1 microM ifenprodil, compatible with the involvement of a NR1/NR2A/NR2B assembly, although the presence of two separate receptor populations, i.e., NR1/NR2A and NR1/NR2B, cannot be excluded.	Zinc	50-52	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	123-127
17983245-0	2007	Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.	Zinc	67-69	amyloid beta precursor protein	Homo sapiens	16-28
17983245-0	2007	Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.	Zinc	99-101	amyloid beta precursor protein	Homo sapiens	16-28
17983245-5	2007	The results suggest that Zn binding to Abeta induces a release of approximately 0.9 proton by the peptide.	Zinc	25-27	amyloid beta precursor protein	Homo sapiens	39-44
17983245-8	2007	Moreover, the apparent dissociation constant (Kd,app) of Zn binding to all forms of Abeta is in the low micromolar range (1-20 microM) and rather independent of the aggregation state including soluble Abeta, Abeta fibrils, or Zn-induced Abeta aggregates.	Zinc	57-59	amyloid beta precursor protein	Homo sapiens	84-89
17983245-8	2007	Moreover, the apparent dissociation constant (Kd,app) of Zn binding to all forms of Abeta is in the low micromolar range (1-20 microM) and rather independent of the aggregation state including soluble Abeta, Abeta fibrils, or Zn-induced Abeta aggregates.	Zinc	57-59	amyloid beta precursor protein	Homo sapiens	201-206
17983245-8	2007	Moreover, the apparent dissociation constant (Kd,app) of Zn binding to all forms of Abeta is in the low micromolar range (1-20 microM) and rather independent of the aggregation state including soluble Abeta, Abeta fibrils, or Zn-induced Abeta aggregates.	Zinc	57-59	amyloid beta precursor protein	Homo sapiens	201-206
17983245-8	2007	Moreover, the apparent dissociation constant (Kd,app) of Zn binding to all forms of Abeta is in the low micromolar range (1-20 microM) and rather independent of the aggregation state including soluble Abeta, Abeta fibrils, or Zn-induced Abeta aggregates.	Zinc	226-228	amyloid beta precursor protein	Homo sapiens	84-89
17983245-9	2007	Finally, Zn in the soluble or aggregated Zn-Abeta form is well accessible for Zn chelators.	Zinc	9-11	amyloid beta precursor protein	Homo sapiens	44-49
17983245-9	2007	Finally, Zn in the soluble or aggregated Zn-Abeta form is well accessible for Zn chelators.	Zinc	41-43	amyloid beta precursor protein	Homo sapiens	44-49
17848574-8	2007	MDM2 in which one of the Zn(2+) coordinating residues is mutated (C478S or C464A) blocks degradation but enhances folding of p53.	Zinc	25-27	tumor protein p53	Homo sapiens	125-128
17726014-2	2007	The N-terminal cysteine of TIMP-1 plays a key role in the inhibitory activity of the protein because it coordinates the essential catalytic Zn2+ of the MMP, preventing the metal ion from functioning.	Zinc	140-144	TIMP metallopeptidase inhibitor 1	Homo sapiens	27-33
17950062-5	2007	The Zn(II)-imprinted microbeads have a greater affinity for Zn(II) with respect to Cu(II), Co(II) and Ni(II) ions.	Zinc	4-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
17950062-5	2007	The Zn(II)-imprinted microbeads have a greater affinity for Zn(II) with respect to Cu(II), Co(II) and Ni(II) ions.	Zinc	60-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
17878266-0	2007	The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors.	Zinc	73-77	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	31-34
17878266-6	2007	However, deletion of either the NR1 or the NR2 NTD eliminated high-affinity, allosteric inhibition of agonist-induced currents by Zn2+ and ifenprodil, consistent with the idea that interdomain interactions between these domains are important for allosteric receptor modulation.	Zinc	130-134	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	32-35
17437303-8	2007	Zn2+, as one possible candidate, antagonized the Ni2+ inhibition of BMP-2-induced ALP in both MC3T3-E1 and human bone marrow stromal cells.	Zinc	0-4	bone morphogenetic protein 2	Mus musculus	68-73
18221229-3	2007	The amyloid beta (Abeta) peptide and its parental molecule, the amyloid precursor protein (APP) both modulate Cu and Zn metabolism in the brain.	Zinc	117-119	amyloid beta precursor protein	Homo sapiens	64-89
17877375-5	2007	Biochemical analyses using purified TrpRS demonstrated that heme can interact strongly with Zn2+-depleted human full-length TrpRS with a stoichiometric heme:protein ratio of 1:1 to enhance the aminoacylation activity significantly.	Zinc	92-96	tryptophanyl-tRNA synthetase 1	Homo sapiens	36-41
17877375-5	2007	Biochemical analyses using purified TrpRS demonstrated that heme can interact strongly with Zn2+-depleted human full-length TrpRS with a stoichiometric heme:protein ratio of 1:1 to enhance the aminoacylation activity significantly.	Zinc	92-96	tryptophanyl-tRNA synthetase 1	Homo sapiens	124-129
17877375-6	2007	In contrast, the Zn2+-bound form of TrpRS did not bind heme.	Zinc	17-21	tryptophanyl-tRNA synthetase 1	Homo sapiens	36-41
17845040-2	2007	While the intermolecular reaction of acrylates, acrylonitriles, and vinyl sulfones with alkynes takes place in the presence of CoI2(PPh3)2/Zn, the reaction of enones and enals with alkynes requires the use of the CoI2(dppe)/Zn/ZnI2 system.	Zinc	139-141	caveolin 1	Homo sapiens	132-136
17845040-2	2007	While the intermolecular reaction of acrylates, acrylonitriles, and vinyl sulfones with alkynes takes place in the presence of CoI2(PPh3)2/Zn, the reaction of enones and enals with alkynes requires the use of the CoI2(dppe)/Zn/ZnI2 system.	Zinc	224-226	caveolin 1	Homo sapiens	132-136
17901898-1	2007	Lactoferrin (LTF) is a multifunctional iron-binding protein that is also capable of binding other divalent metal cations, especially Zn2+.	Zinc	133-137	lactotransferrin	Homo sapiens	0-11
17901898-1	2007	Lactoferrin (LTF) is a multifunctional iron-binding protein that is also capable of binding other divalent metal cations, especially Zn2+.	Zinc	133-137	lactotransferrin	Homo sapiens	13-16
17885553-4	2007	Angiotensin-converting enzyme (ACE), responsible for vasoconstriction, is a zinc (Zn) containing enzyme.	Zinc	82-84	angiotensin I converting enzyme	Homo sapiens	0-29
17885553-4	2007	Angiotensin-converting enzyme (ACE), responsible for vasoconstriction, is a zinc (Zn) containing enzyme.	Zinc	82-84	angiotensin I converting enzyme	Homo sapiens	31-34
17885553-5	2007	We therefore hypothesized that H2S may interact with the Zn in the active center of ACE, modulating (inhibiting) enzyme activity.	Zinc	57-59	angiotensin I converting enzyme	Homo sapiens	84-87
17885553-8	2007	RESULTS: H2S inhibited the activity of ACE in HUVEC protein extracts in a dose-dependent manner, and only Zn but not Cd, Ca or Mg could counteract the inhibitory effect.	Zinc	106-108	angiotensin I converting enzyme	Homo sapiens	39-42
17885553-11	2007	CONCLUSION: H2S exhibits direct inhibitory action on ACE activity in HUVECs, obviously by interfering with the Zn in the active center of the enzyme.	Zinc	111-113	angiotensin I converting enzyme	Homo sapiens	53-56
17292662-2	2007	Detailed investigations of the EPR spectra indicate that Cu(2+) ion substitute with Zn(2+) ion and forms tetrahedral complex in [Zn(sac)2(dmen)] and octahedral complex in [Zn(sac)2(paen)] hosts.	Zinc	84-86	inositol polyphosphate-5-phosphatase F	Homo sapiens	132-137
17482352-1	2007	Sintering operation in the production of Zn, Cd, and Pb by Waelz process produces a powdery waste containing mainly (about 70%) ZnO, CdO, and PbO.	Zinc	41-43	cell adhesion associated, oncogene regulated	Homo sapiens	133-136
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	162-191
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	poly(ADP-ribose) polymerase 1	Homo sapiens	193-199
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	205-236
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	238-241
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	244-264
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	266-269
17570352-9	2007	A Western blot analysis further showed that ZnCl(2) significantly enhances phosphorylation of ERK, confirming the involvement of ERK in the action of Zn(2+).	Zinc	44-46	Eph receptor B1	Rattus norvegicus	94-97
17718543-2	2007	Zn2+ at a concentration of a few micromolar, which is too dilute to affect the precipitation equilibrium of Abeta, can destabilize these aggregates [Garai, K., Sengupta, P., Sahoo, B., and Maiti, S. (2006) Biochem.	Zinc	0-4	amyloid beta precursor protein	Homo sapiens	108-113
17712447-2	2007	The pH rate profiles of values of the observed second-order rate constant log (k(Zn))(app) for Zn(X)(OH(2))-catalyzed cleavage (X = 1, 2, 3 and 4) of 2-hydroxypropyl-4-nitrophenyl phosphate (HpPNP) show downward breaks centered at the pK(a) for ionization of the respective zinc bound water.	Zinc	81-83	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	128-145
17686982-3	2007	We have previously used Zn(2+) to modulate the assembly kinetics and morphology of congeners of the amyloid beta peptide (Abeta) associated with Alzheimer"s disease.	Zinc	24-26	amyloid beta precursor protein	Homo sapiens	122-127
17570352-9	2007	A Western blot analysis further showed that ZnCl(2) significantly enhances phosphorylation of ERK, confirming the involvement of ERK in the action of Zn(2+).	Zinc	44-46	Eph receptor B1	Rattus norvegicus	129-132
17848732-3	2007	The objective of this study was to determine whether Zn could stimulate protein phosphorylation in the mTOR pathway in vivo.	Zinc	53-55	mechanistic target of rapamycin kinase	Homo sapiens	103-107
17324120-10	2007	A possible mechanism for the activation of Cn was identified in our studies as the prevention of Fe and Zn losses from the active site of Cn, suggesting a conformation-dependent SOD1-Cn interaction.	Zinc	104-106	superoxide dismutase 1	Homo sapiens	178-182
17497728-0	2007	Selective oxidation of Zn2+ -insulin catalyzed by Cu2+.	Zinc	23-27	insulin	Homo sapiens	29-36
17497728-1	2007	The purpose of this study is to quantitate the sensitivity of Zn2+ -insulin to oxidation catalyzed by various redox active transition metals, Cu2+, Fe2+, Mn2+, Ni2+, Co2+, Cr3+.	Zinc	62-66	insulin	Homo sapiens	68-75
17497728-2	2007	Human recombinant insulin (INS) was subjected to oxidation under various conditions in the presence and absence of Zn2+ and ascorbate.	Zinc	115-119	insulin	Homo sapiens	18-25
17490871-3	2007	A recombinant fragment of FN incorporating type III repeats 12-15, and including the alternatively-spliced type three connecting segment (IIICS), was found to bind Ni(2+), Cu(2+) and Zn(2+) divalent cations, whereas a similar fragment lacking the IIICS did not.	Zinc	183-185	fibronectin 1	Homo sapiens	26-28
17434750-8	2007	The enzyme activity with peptide derived from HIF-1alpha was inhibited by Zn(2+), desferrioxamine and imidazole.	Zinc	74-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
17728843-9	2007	These findings suggest that release of Zn2+ from neurons during brain insults could induce PARP-1 activation in astrocytes, leading to impaired glutamate uptake and exacerbation of neuronal injury.	Zinc	39-43	poly(ADP-ribose) polymerase 1	Homo sapiens	91-97
17552555-1	2007	In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands.	Zinc	24-27	transferrin	Homo sapiens	134-145
17499269-5	2007	The Pygo1 PHD structure forms a canonical PHD finger motif, stabilized by two Zn ions coordinated in a cross-brace scheme.	Zinc	78-80	pygopus family PHD finger 1	Homo sapiens	4-9
17552555-1	2007	In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands.	Zinc	24-27	claudin 4	Homo sapiens	155-164
17196802-1	2007	The physical stability and the secondary structure of a glucagon-like peptide-1 derivative were investigated in the presence of the metal ions Al(3+), Zn(2+), Mg(2+), and K(+), known as possible leachables from container-closure systems.	Zinc	151-153	glucagon	Homo sapiens	56-79
17511455-1	2007	Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-beta (A beta) peptide are hypothesized to play an important role in the etiology of Alzheimer"s disease (AD).	Zinc	57-59	amyloid beta precursor protein	Homo sapiens	78-90
17511455-1	2007	Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-beta (A beta) peptide are hypothesized to play an important role in the etiology of Alzheimer"s disease (AD).	Zinc	57-59	amyloid beta precursor protein	Homo sapiens	92-98
17709905-7	2007	The renin-angiotensin-aldosterone system correlated with Zn metabolism parameters.	Zinc	57-59	renin	Homo sapiens	4-9
17709905-8	2007	In premenopausal women, plasma renin activity and serum aldosterone showed positive correlations with lymphocyte Zn (Znl) (k = 0.63 and k = 0.41, respectively), and in postmenopausal women, it correlated negatively with Zn-s (k = -0.38) and whole aldosterone correlated negatively with ERCos-Zn (k = -0.41).	Zinc	113-115	renin	Homo sapiens	31-36
17709905-8	2007	In premenopausal women, plasma renin activity and serum aldosterone showed positive correlations with lymphocyte Zn (Znl) (k = 0.63 and k = 0.41, respectively), and in postmenopausal women, it correlated negatively with Zn-s (k = -0.38) and whole aldosterone correlated negatively with ERCos-Zn (k = -0.41).	Zinc	220-224	renin	Homo sapiens	31-36
17425332-6	2007	Herein, the effect of copper (Cu2+), zinc (Zn2+), and calcium (Ca2+) on the structure and stability of SAA2.2 in aqueous solution was examined using various probes of quaternary, tertiary, and secondary structure.	Zinc	43-47	serum amyloid A 2	Mus musculus	103-107
17405798-9	2007	Meanwhile, the Co(2+)-dependent activation was inhibited competitively by Zn(2+) ion (0.1-1.0 muM) added, similarly to that it is inhibited by higher concentration of Co(2+) ion.	Zinc	74-80	latexin	Homo sapiens	94-97
17425332-11	2007	Complete aggregation of SAA2.2 was also observed when it was incubated with 1 mM Cu2+ or Zn2+, further demonstrating the tenuous structure and stability of SAA2.2.	Zinc	89-93	serum amyloid A 2	Mus musculus	24-28
17595415-7	2007	Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6.	Zinc	15-17	CD4 molecule	Homo sapiens	68-71
17538243-2	2007	We used a DNA microarray to assess transcriptional alterations in human HeLa cells after exposure to a moderate concentration of Zn (100 muM ZnSO(4)).	Zinc	129-131	latexin	Homo sapiens	137-140
17425332-11	2007	Complete aggregation of SAA2.2 was also observed when it was incubated with 1 mM Cu2+ or Zn2+, further demonstrating the tenuous structure and stability of SAA2.2.	Zinc	89-93	serum amyloid A 2	Mus musculus	156-160
17240422-5	2007	Moreover, the influence of different metal ions (Pb(2+), Cd(2+), Zn(2+)) was examined and results indicated that the presence of heavy metals inhibited the sorption of PNP in the order: Pb(2+)&gt;Cd(2+)&gt;Zn(2+).	Zinc	65-67	purine nucleoside phosphorylase	Homo sapiens	168-171
17240422-5	2007	Moreover, the influence of different metal ions (Pb(2+), Cd(2+), Zn(2+)) was examined and results indicated that the presence of heavy metals inhibited the sorption of PNP in the order: Pb(2+)&gt;Cd(2+)&gt;Zn(2+).	Zinc	206-208	purine nucleoside phosphorylase	Homo sapiens	168-171
17321793-7	2007	Furthermore, addition of Zn(2+), Mn(2+), Ni(2+), or Co(2+) to diluted egg white altered preference patterns of lysoPLD toward choline-containing substrates.	Zinc	25-31	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	111-118
19071644-4	2007	In the case of the whole Zn(7)-MT, the addition of seven equivalents of Pb(II) give rise to the formation of several Pb(x)Zn(y)-MT species (x+y=7 or 8) as well as Pb(8)-MT and Pb(9)-MT coexisting with the initial Zn(7)-MT species.	Zinc	25-27	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
19071644-4	2007	In the case of the whole Zn(7)-MT, the addition of seven equivalents of Pb(II) give rise to the formation of several Pb(x)Zn(y)-MT species (x+y=7 or 8) as well as Pb(8)-MT and Pb(9)-MT coexisting with the initial Zn(7)-MT species.	Zinc	122-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
19071644-4	2007	In the case of the whole Zn(7)-MT, the addition of seven equivalents of Pb(II) give rise to the formation of several Pb(x)Zn(y)-MT species (x+y=7 or 8) as well as Pb(8)-MT and Pb(9)-MT coexisting with the initial Zn(7)-MT species.	Zinc	122-124	submaxillary gland androgen regulated protein 3B	Homo sapiens	72-78
19071644-9	2007	The results obtained were consistent with the increase of MT synthesis in response to Pb(2+) administered to rats reported in the literature, since the initial release of Zn(II) would promote the biosynthesis of MT, in agreement with the function of this ion as primary activator of the MTF-1 transcription factor; and could explain the difficulty of recovering homonuclear Pb-MT species from lead-treated organisms.	Zinc	171-177	metal-regulatory transcription factor 1	Rattus norvegicus	287-292
17367129-5	2007	The beta1 and beta2 global formation constants for the [M(LOH)]2+ and [M(LOH)2]2+ species were obtained and are in agreement with the Irving-Williams series: Ni2+&lt; Cu2+&gt; Zn2+.	Zinc	176-180	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-9
17326675-1	2007	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of two homologous domains (N- and C-), each bearing a Zn-dependent active site.	Zinc	150-152	angiotensin I converting enzyme	Homo sapiens	0-31
17391061-2	2007	IRAP belongs to the M1 family of Zn2+-dependent aminopeptidases characterized by a catalytic domain that contains two conserved motifs, the HEXXH(X)18E Zn2+-binding motif and the GXMEN exopeptidase motif.	Zinc	33-37	leucyl and cystinyl aminopeptidase	Homo sapiens	0-4
17624187-5	2007	Zn-supplement increased the CD4+/CD3+ cell percentage, and simultaneously decreased the CD8+/CD3+ cell population.	Zinc	0-2	CD4 molecule	Homo sapiens	28-31
17326675-1	2007	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of two homologous domains (N- and C-), each bearing a Zn-dependent active site.	Zinc	150-152	angiotensin I converting enzyme	Homo sapiens	33-36
17326675-6	2007	This implies that the binding of ACE inhibitors or removal of Zn2+ from ACE active centers causes conformational adjustments in the mutual arrangement of N- and C-domains in the two-domain ACE molecule.	Zinc	62-66	angiotensin I converting enzyme	Homo sapiens	72-75
17326675-6	2007	This implies that the binding of ACE inhibitors or removal of Zn2+ from ACE active centers causes conformational adjustments in the mutual arrangement of N- and C-domains in the two-domain ACE molecule.	Zinc	62-66	angiotensin I converting enzyme	Homo sapiens	72-75
20535382-4	2007	Also, the expression of bone-related genes (ALP, Runx2, PTH-R, ProCOL I, OPN and OC) was measured on the cellular Zn depletion such as chelexing or TPEN treatment.	Zinc	114-116	alopecia, recessive	Mus musculus	44-47
17277087-1	2007	Zinc (Zn) is an essential micronutrient required by all cells but is toxic in excess.	Zinc	6-8	zinc induced facilitator 1	Arabidopsis thaliana	0-4
17277087-4	2007	Shoots of zif1 mutants showed increased accumulation of Zn but not other metal ions.	Zinc	56-58	zinc induced facilitator 1	Arabidopsis thaliana	10-14
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	72-76
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	188-192
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	72-76
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	188-192
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	72-76
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	188-192
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	72-76
17277087-5	2007	In combination with mutations affecting shoot-to-root Zn translocation, zif1 hma2 hma4 triple mutants accumulated less Zn than the wild type but remained Zn sensitive, suggesting that the zif1 Zn-sensitive phenotype is due to altered Zn distribution.	Zinc	119-121	zinc induced facilitator 1	Arabidopsis thaliana	188-192
17277087-8	2007	ZIF1 expression was highly induced by Zn and, to a lesser extent, by manganese.	Zinc	38-40	zinc induced facilitator 1	Arabidopsis thaliana	0-4
17277087-10	2007	MTP1 has been identified as a tonoplast Zn transporter and a zif1-1 mtp1-1 double mutant was more sensitive to Zn than either of the single mutants, suggesting ZIF1 influences a distinct mechanism of Zn homeostasis.	Zinc	111-113	zinc induced facilitator 1	Arabidopsis thaliana	61-65
17277087-11	2007	Overexpression of ZIF1 conferred increased Zn tolerance and interveinal leaf chlorosis in some transgenic lines in which ZIF1 expression was high.	Zinc	43-45	zinc induced facilitator 1	Arabidopsis thaliana	18-22
17277087-12	2007	We propose that ZIF1 is involved in a novel mechanism of Zn sequestration, possibly by transport of a Zn ligand or a Zn ligand complex into vacuoles.	Zinc	57-59	zinc induced facilitator 1	Arabidopsis thaliana	16-20
17277087-12	2007	We propose that ZIF1 is involved in a novel mechanism of Zn sequestration, possibly by transport of a Zn ligand or a Zn ligand complex into vacuoles.	Zinc	102-104	zinc induced facilitator 1	Arabidopsis thaliana	16-20
17277087-12	2007	We propose that ZIF1 is involved in a novel mechanism of Zn sequestration, possibly by transport of a Zn ligand or a Zn ligand complex into vacuoles.	Zinc	102-104	zinc induced facilitator 1	Arabidopsis thaliana	16-20
19071568-5	2007	The proposed method enables determination of particular metal ion at the ng mL(-1) level and it was successfully applied to the determination impurities from heavy metal traces in pharmaceutical substances (Cu in ascorbic acid, Pb in glucose, and Zn in insulin).	Zinc	247-249	insulin	Homo sapiens	253-260
17365305-4	2007	It is documented that induction of MT by zinc (Zn+2) protects against metal and non-metal hepatotoxicity.	Zinc	47-51	metallothionein 4	Gallus gallus	35-37
17297920-0	2007	Zn(2+)-dependent misfolding of the p53 DNA binding domain.	Zinc	0-6	tumor protein p53	Homo sapiens	35-38
17365305-5	2007	In this study the MT induction was examined through pretreatment of the two highest Pt(IV) exposure levels with exogenous Zn2+ on the 4th and 11th days of incubation.	Zinc	122-126	metallothionein 4	Gallus gallus	18-20
17028131-5	2007	Furthermore, Abeta sheets, serving as condensation nuclei, were crucial for DNA condensation, and Cu(2+) and Zn(2+) ions inhibited Abeta sheet-induced DNA condensation.	Zinc	109-111	amyloid beta precursor protein	Homo sapiens	131-136
17255946-4	2007	SOD1 folding requires tight Zn but not Cu binding and proceeds through at least three kinetically and biochemically distinct states.	Zinc	28-30	superoxide dismutase 1	Homo sapiens	0-4
18415980-10	2007	Recently the G245C substitution has been assumed to result in formation of a novel Zn(2+)-binding site in the p53 protein.	Zinc	83-89	tumor protein p53	Homo sapiens	110-113
17917440-6	2007	Only uric acid and Zn showed significant correlation with CD4 count.	Zinc	19-21	CD4 molecule	Homo sapiens	58-61
17849985-3	2007	The purpose of this study is to evaluate the effectiveness of a pre-treatment based on chemical precipitation with chelating agents (TMT: 2,4,6-trimercaptotriazine), for the reduction of Cu and Zn from raw winery wastewater.	Zinc	194-196	tryptase gamma 1	Homo sapiens	133-136
17849985-7	2007	The results confirmed the feasibility of using TMT treatment for the reduction of Cu and Zn in order to meet the limits for discharge into the sewerage.	Zinc	89-91	tryptase gamma 1	Homo sapiens	47-50
17176059-1	2006	The salivary antimicrobial peptide histatin 5 is characterized by its cationic nature, structural flexibility, and the presence of two metal-binding sites (the ATCUN motif and a Zn-binding motif).	Zinc	178-180	histatin 3	Homo sapiens	35-45
17046817-9	2006	The sequestration of Zn(2+) ions from the N-terminal fibrinogen-binding region abrogated decorin incorporation into the fibrin network.	Zinc	21-23	fibrinogen beta chain	Homo sapiens	53-63
17183156-6	2006	Since Abeta deposition could be altered by certain metals like Cu and Zn, we have also measured the effects of dialysis on the levels of these ions in plasma.	Zinc	70-72	amyloid beta precursor protein	Homo sapiens	6-11
17107129-0	2006	Intramolecular vibrational preparation of the unfolding transition state of Zn(II)-substituted cytochrome c.	Zinc	76-82	cytochrome c, somatic	Homo sapiens	95-107
17107129-2	2006	Using this approach, we examine the effect of the polarity and viscosity of the solvent medium on the unfolding and refolding reactions of Zn(II)-substituted cytochrome c at room temperature.	Zinc	139-145	cytochrome c, somatic	Homo sapiens	158-170
17114051-6	2006	Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs, indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.	Zinc	76-78	glycine receptor, alpha 1 subunit	Mus musculus	37-42
17114051-6	2006	Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs, indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.	Zinc	157-159	glycine receptor, alpha 1 subunit	Mus musculus	37-42
16973622-1	2006	We found that the Cu(II) and Zn(II)-specific chelator Clioquinol (10-50 microM) increased functional hypoxia-inducible factor 1alpha (HIF-1alpha) protein, leading to increased expression of its target genes, vascular endothelial growth factors and erythropoietin, in SH-SY5Y cells and HepG2 cells.	Zinc	29-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-132
17077892-12	2006	Acid-assisted dissociations of metal(II) complexes occur predominantly through triprotonated species [M(H3L)]+ and take place at pH &lt; 5 (Zn2+) and pH &lt; 6 (Cd2+).	Zinc	140-144	H3 clustered histone 2	Homo sapiens	104-107
16973622-1	2006	We found that the Cu(II) and Zn(II)-specific chelator Clioquinol (10-50 microM) increased functional hypoxia-inducible factor 1alpha (HIF-1alpha) protein, leading to increased expression of its target genes, vascular endothelial growth factors and erythropoietin, in SH-SY5Y cells and HepG2 cells.	Zinc	29-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
16973622-1	2006	We found that the Cu(II) and Zn(II)-specific chelator Clioquinol (10-50 microM) increased functional hypoxia-inducible factor 1alpha (HIF-1alpha) protein, leading to increased expression of its target genes, vascular endothelial growth factors and erythropoietin, in SH-SY5Y cells and HepG2 cells.	Zinc	29-31	erythropoietin	Homo sapiens	248-262
16973622-2	2006	Clioquinol inhibited ubiquitination of HIF-1alpha in a Cu(II)- and Zn(II)-dependent manner.	Zinc	67-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
16973622-3	2006	It prevents FIH-1 from hydroxylating the asparagine residue (803) of HIF-1alpha in a Cu(II)- and Zn(II)-independent fashion.	Zinc	97-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	Zinc	10-14	AKT serine/threonine kinase 1	Homo sapiens	42-45
17055757-4	2006	A recent report that Pb is able to replace Zn in the Zn fingers of the hematopoietic transcription factor GATA-1 prompted us to address this hypothesis in the setting of MEL cell differentiation.	Zinc	43-45	GATA binding protein 1	Homo sapiens	106-112
17055757-4	2006	A recent report that Pb is able to replace Zn in the Zn fingers of the hematopoietic transcription factor GATA-1 prompted us to address this hypothesis in the setting of MEL cell differentiation.	Zinc	53-55	GATA binding protein 1	Homo sapiens	106-112
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	forkhead box O1	Homo sapiens	85-91
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	forkhead box O1	Homo sapiens	172-178
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	AKT serine/threonine kinase 1	Homo sapiens	194-197
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	Zinc	89-93	AKT serine/threonine kinase 1	Homo sapiens	21-24
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	Zinc	89-93	forkhead box O1	Homo sapiens	183-189
16815035-6	2006	The addition of both a neutralization step and the inclusion of Zn(2+) to the equilibration buffer in desalting step provides considerable enhancement in the yield of active PSMA from LNCaP cells.	Zinc	64-70	folate hydrolase 1	Homo sapiens	174-178
16964525-3	2006	AP-1 can be activated in Zn deficiency that can occur secondary to an increase in cellular H(2)O(2), followed by activation of MAPKs p38 and JNK.	Zinc	25-27	mitogen-activated protein kinase 14	Homo sapiens	133-136
16964525-3	2006	AP-1 can be activated in Zn deficiency that can occur secondary to an increase in cellular H(2)O(2), followed by activation of MAPKs p38 and JNK.	Zinc	25-27	mitogen-activated protein kinase 8	Homo sapiens	141-144
16964525-4	2006	Similarly, the cytosolic steps of the NF-kappaB cascade are activated by oxidants in Zn deficiency.	Zinc	85-87	nuclear factor kappa B subunit 1	Homo sapiens	38-47
16964525-6	2006	We present here evidence that, following experimental depletion of Zn, both NF-kappaB and AP-1 signallings are altered in primary T cells isolated from young and elderly healthy individuals under CD3/CD28 costimulation.	Zinc	67-69	nuclear factor kappa B subunit 1	Homo sapiens	76-85
16964525-6	2006	We present here evidence that, following experimental depletion of Zn, both NF-kappaB and AP-1 signallings are altered in primary T cells isolated from young and elderly healthy individuals under CD3/CD28 costimulation.	Zinc	67-69	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
16964525-7	2006	A supplementation of Zn restored both NF-kappaB and AP-1 activation in CD3/CD28 costimulated T cells from young, but not from elderly, healthy individuals, indicating that the Zn deficiency is only one component of a more complex mechanism involved in immunosenescence.	Zinc	21-23	nuclear factor kappa B subunit 1	Homo sapiens	38-47
16964525-7	2006	A supplementation of Zn restored both NF-kappaB and AP-1 activation in CD3/CD28 costimulated T cells from young, but not from elderly, healthy individuals, indicating that the Zn deficiency is only one component of a more complex mechanism involved in immunosenescence.	Zinc	21-23	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
17005717-2	2006	Here we show that zinc transporter 3 (ZnT-3), which maintains a high concentration of Zn2+ in synaptic vesicles and serves as a marker for zinc-containing neurons, is enriched in the lateral nucleus of the amygdala and in the temporal area 3 of the auditory cortex, an area that conveys information about the auditory conditioned stimulus to the lateral nucleus of the amygdala, but not in other conditioned stimulus areas located in the auditory thalamus.	Zinc	86-90	solute carrier family 30 member 3	Homo sapiens	18-36
17005717-2	2006	Here we show that zinc transporter 3 (ZnT-3), which maintains a high concentration of Zn2+ in synaptic vesicles and serves as a marker for zinc-containing neurons, is enriched in the lateral nucleus of the amygdala and in the temporal area 3 of the auditory cortex, an area that conveys information about the auditory conditioned stimulus to the lateral nucleus of the amygdala, but not in other conditioned stimulus areas located in the auditory thalamus.	Zinc	86-90	solute carrier family 30 member 3	Homo sapiens	38-43
17008722-6	2006	Focusing on residues near the extracellular ends of hSERT TMHs I and III, we engineered potential Zn2+-binding sites between V102 or W103 (TMH I) and I179-L184 (TMH III).	Zinc	98-102	solute carrier family 6 member 4	Homo sapiens	52-57
17008722-9	2006	Dose-response assays suggest an approximately twofold increase in sensitivity to Zn2+ inhibition at the hSERT V102C/M180C and approximately fourfold at the V102C/I179C mutant compared to the hSERT V102C single mutant.	Zinc	81-85	solute carrier family 6 member 4	Homo sapiens	104-109
17008722-9	2006	Dose-response assays suggest an approximately twofold increase in sensitivity to Zn2+ inhibition at the hSERT V102C/M180C and approximately fourfold at the V102C/I179C mutant compared to the hSERT V102C single mutant.	Zinc	81-85	solute carrier family 6 member 4	Homo sapiens	191-196
16839579-3	2006	ZN-1 and ZN-2 inhibited the proliferation of ERalpha and ERbeta positive (MCF-7) and negative (MCF-10A) breast cells, further ruling out direct binding to ER in the mechanism of action of these compounds.	Zinc	9-13	estrogen receptor 1	Homo sapiens	45-52
16924290-2	2006	The protonation constants of L1 and L2 and the stability constants of their complexes with Ni2+, Cu2+, Zn2+ and Cd2+ metal ions were determined in aqueous solutions by potentiometry, at 298.2 K and ionic strength 0.10 mol dm(-3) in KNO3.	Zinc	103-107	L1 cell adhesion molecule	Homo sapiens	29-38
17022662-4	2006	The MT-driven improvement in metal biosorption relied more on the increase in the biosorption rates (r(2), a kinetic property) than on the equilibrium biosorption capacities (q(max), a thermodynamic property), despite a 10-45% and 30-80% increase in q(max) of Cd and Zn, respectively.	Zinc	267-269	metallothionein 1A	Homo sapiens	4-6
16964525-2	2006	Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1).	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	189-211
16964525-2	2006	Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1).	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	213-222
16964525-2	2006	Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1).	Zinc	0-2	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	228-247
16964525-2	2006	Zn deficiency-triggered oxidative stress could affect cell signalling, including transcription factors containing Zn finger motifs and other oxidant-sensitive transcription factors such as nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1).	Zinc	0-2	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	249-253
16964525-3	2006	AP-1 can be activated in Zn deficiency that can occur secondary to an increase in cellular H(2)O(2), followed by activation of MAPKs p38 and JNK.	Zinc	25-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
16844225-6	2006	It is shown that Zn(II) and its substitutes Cd(II)/Co(II) bind to humanin via a thiolate bond from the side chain of the single cysteine at position 8.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17022662-7	2006	Moreover, the overall biosorption efficiency (eta(ads)) of the MT-expressing recombinant biosorbents was found to be adsorbate-dependent: the eta(ads) values decreased in the order of Cd &gt; Cu &gt; Zn &gt; Pb.	Zinc	200-202	metallothionein 1A	Homo sapiens	63-65
16741752-7	2006	An increased cation influx rate, through the LTCC, was also recorded for Zn(2+) and Cd(2+) in cells treated with the ZnT-1 siRNA.	Zinc	73-75	solute carrier family 30 member 1	Homo sapiens	117-122
17044644-12	2006	The decrease of serum CuZnSOD was related to the excretion of Zn2+.	Zinc	62-66	superoxide dismutase 1	Rattus norvegicus	22-29
16584753-7	2006	In contrast, in the retinas exposed to ischemia without the administration of the zinc ion chelators (Ca2+-EDTA and TPEN), Zn2+ deposits were found in the IPL and INL beginning 4 h after ischemia and degeneration of neurons was found in the GCL and INL.	Zinc	123-127	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	241-244
16799759-2	2006	In this work, the key role of Zn(2+) in high-level expression of soluble TRAIL was confirmed.	Zinc	30-32	TNF superfamily member 10	Homo sapiens	73-78
16799759-4	2006	Furthermore, the purified TRAIL showed stronger cytotoxicity activity against human pancreatic 1990 tumor cells as the molar ratio of Zn(2+) to TRAIL monomer was 2 in purified TRAIL solution.	Zinc	134-136	TNF superfamily member 10	Homo sapiens	26-31
17120928-3	2006	We constructed a recombinant adenoviral vector, RAd-metFTS, expressing a synthetic DNA sequence encoding met-FTS, an analog of the thymic peptide facteur thymique serique (FTS), whose Zn-bound biologically active form is known as thymulin.	Zinc	184-186	Ras-related associated with diabetes	Mus musculus	48-51
16624472-3	2006	Incubation of AT-I with recombinant human Cu,Zn-superoxide dismutase (rhCu,Zn-SOD) resulted in rhCu,Zn-SOD fragmentations and Zn releases.	Zinc	75-77	superoxide dismutase 1	Homo sapiens	42-68
16556455-4	2006	All the consortia were able to accumulate zinc and the best accumulator, named Ing5, has been studied for the following characteristics: resistance and accumulation of Zn, Cd, Hg, bioaccumulation mechanisms of Zn, and influence of Zn and Cd on the metabolic profile.	Zinc	168-170	inhibitor of growth family member 5	Homo sapiens	79-83
16556455-4	2006	All the consortia were able to accumulate zinc and the best accumulator, named Ing5, has been studied for the following characteristics: resistance and accumulation of Zn, Cd, Hg, bioaccumulation mechanisms of Zn, and influence of Zn and Cd on the metabolic profile.	Zinc	210-212	inhibitor of growth family member 5	Homo sapiens	79-83
16556455-4	2006	All the consortia were able to accumulate zinc and the best accumulator, named Ing5, has been studied for the following characteristics: resistance and accumulation of Zn, Cd, Hg, bioaccumulation mechanisms of Zn, and influence of Zn and Cd on the metabolic profile.	Zinc	210-212	inhibitor of growth family member 5	Homo sapiens	79-83
16556455-5	2006	The results indicate that the consortium Ing5 bears resistance systems for Cd and Hg as well as Zn and that, for some of the 5 isolates belonging to Ing5, the resistance thresholds are higher in consortium than in pure culture.	Zinc	96-98	inhibitor of growth family member 5	Homo sapiens	41-45
16691570-9	2006	The magnitude of the oscillations is smaller in ZnS:Se than in ZnS:O, because the difference between the anion radii of S2- and Se2- is smaller than between S2- and O2-.	Zinc	48-51	fucosyltransferase 2	Homo sapiens	128-131
16691570-9	2006	The magnitude of the oscillations is smaller in ZnS:Se than in ZnS:O, because the difference between the anion radii of S2- and Se2- is smaller than between S2- and O2-.	Zinc	63-66	fucosyltransferase 2	Homo sapiens	128-131
16810319-3	2006	These studies show that the three Zn ion-containing HDAC6 ZnF-UBP domain presents the highest known affinity for ubiquitin monomers and mediates the ability of HDAC6 to negatively control the cellular polyubiquitin chain turnover.	Zinc	34-36	histone deacetylase 6	Homo sapiens	52-57
16810319-3	2006	These studies show that the three Zn ion-containing HDAC6 ZnF-UBP domain presents the highest known affinity for ubiquitin monomers and mediates the ability of HDAC6 to negatively control the cellular polyubiquitin chain turnover.	Zinc	34-36	histone deacetylase 6	Homo sapiens	160-165
16750816-1	2006	In the mammalian pancreas, high concentrations of Zn(2+) are co-secreted with insulin, which may then permeate via abundant L-type Ca(2+) channels (LTCC) present on the beta-cells.	Zinc	50-52	insulin	Homo sapiens	78-85
16848423-3	2006	Altered levels of metals (such as Cu and Zn) exist in the AD brain, and because Cu and Zn can be bound to the Abeta in the amyloid plaques, it is thought that these binding events in vivo may trigger or prevent Abeta amyloid formation in the AD brain.	Zinc	41-43	amyloid beta precursor protein	Homo sapiens	110-115
16848423-3	2006	Altered levels of metals (such as Cu and Zn) exist in the AD brain, and because Cu and Zn can be bound to the Abeta in the amyloid plaques, it is thought that these binding events in vivo may trigger or prevent Abeta amyloid formation in the AD brain.	Zinc	41-43	amyloid beta precursor protein	Homo sapiens	211-216
16848423-3	2006	Altered levels of metals (such as Cu and Zn) exist in the AD brain, and because Cu and Zn can be bound to the Abeta in the amyloid plaques, it is thought that these binding events in vivo may trigger or prevent Abeta amyloid formation in the AD brain.	Zinc	87-89	amyloid beta precursor protein	Homo sapiens	110-115
16848423-3	2006	Altered levels of metals (such as Cu and Zn) exist in the AD brain, and because Cu and Zn can be bound to the Abeta in the amyloid plaques, it is thought that these binding events in vivo may trigger or prevent Abeta amyloid formation in the AD brain.	Zinc	87-89	amyloid beta precursor protein	Homo sapiens	211-216
16848423-5	2006	The present NMR studies utilized uniformly 15N-labeled Abeta(1-40) peptide and 1H-15N HSQC experiments and demonstrate for the first time that the Abeta binds Cu and Zn in a distinct manner.	Zinc	166-168	amyloid beta precursor protein	Homo sapiens	147-152
16842004-1	2006	The self-assembly of 4-hydroxypyridine-2,6-dicarboxylic acid (H(3)CAM) and pyridine-2,6-dicarboxylic acid (H2PDA) with Zn(II) salts under hydrothermal conditions gave two novel coordination polymers {[Zn(HCAM)].H2O}n (1) and {[Zn(PDA)(H2O)(1.5)]}n (1a).	Zinc	119-121	calmodulin 3	Homo sapiens	66-69
16819190-4	2006	At 24 h, protein concentrations and mRNA expressions of MT-I and -II also increased in the respective astrocytes, and were further enhanced when maintained in the presence of 50 microM Zn(2+).	Zinc	185-187	metallothionein 1	Rattus norvegicus	56-68
16818790-9	2006	In addition, we showed that Zn was essential for plasma membrane translocation of protein kinase C and subsequent nuclear translocation of NF-kappaB, leading to cytokine production, such as IL-6 and TNF-alpha.	Zinc	28-30	nuclear factor kappa B subunit 1	Homo sapiens	139-148
16818790-9	2006	In addition, we showed that Zn was essential for plasma membrane translocation of protein kinase C and subsequent nuclear translocation of NF-kappaB, leading to cytokine production, such as IL-6 and TNF-alpha.	Zinc	28-30	interleukin 6	Homo sapiens	190-194
16818790-9	2006	In addition, we showed that Zn was essential for plasma membrane translocation of protein kinase C and subsequent nuclear translocation of NF-kappaB, leading to cytokine production, such as IL-6 and TNF-alpha.	Zinc	28-30	tumor necrosis factor	Homo sapiens	199-208
16730117-3	2006	The adsorption experiments demonstrated the crosslinked CMC template has high adsorption selectivity for Pb(II) ions in solution containing single metal ions or coexistence of three metals ions of Cu(II), Zn(II) and Pb(II).	Zinc	205-207	submaxillary gland androgen regulated protein 3B	Homo sapiens	105-111
16766161-0	2006	An alternative approach to amyloid fibrils morphology: CdSe/ZnS quantum dots labelled beta-amyloid peptide fragments Abeta (31-35), Abeta (1-40) and Abeta (1-42).	Zinc	60-63	amyloid beta precursor protein	Homo sapiens	117-122
16023340-7	2006	However, Co(II)-uptake was inhibited in presence of other metals (Pb, Cd, Cu, Ni, Cr and Zn).	Zinc	89-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
16791493-5	2006	In contrast, presence of Cu2+ induces a destabilisation of the protein, which can be explained by a binding to the Zn2+ binding site in alpha-La, possibly resulting in structural alterations of the protein.	Zinc	115-119	lactalbumin alpha	Homo sapiens	136-144
16410015-3	2006	In order to elucidate the mechanism of Zn2+-induced EGFR activation in HAEC, we treated HAEC with 500 microM ZnSO4 for 5-20 min and measured the state of activation of EGFR, c-Src and PTPs.	Zinc	39-43	epidermal growth factor receptor	Homo sapiens	52-56
16503166-7	2006	Moreover, we first demonstrated that laser capture microdissection coupled with X-ray fluorescence microscopy can be applied to determine elemental profiles (S, Fe, Cu, and Zn) in Abeta amyloid plaques.	Zinc	173-175	amyloid beta precursor protein	Homo sapiens	180-185
16410015-4	2006	Western blots revealed that exposure to Zn2+ results in increased phosphorylation at both trans- and autophosphorylation sites in the EGFR.	Zinc	40-44	epidermal growth factor receptor	Homo sapiens	134-138
16410015-5	2006	Zn2+-mediated EGFR phosphorylation did not require ligand binding and was ablated by the EGFR kinase inhibitor PD153035, but not by the Src kinase inhibitor PP2.	Zinc	0-4	epidermal growth factor receptor	Homo sapiens	14-18
16410015-5	2006	Zn2+-mediated EGFR phosphorylation did not require ligand binding and was ablated by the EGFR kinase inhibitor PD153035, but not by the Src kinase inhibitor PP2.	Zinc	0-4	epidermal growth factor receptor	Homo sapiens	89-93
16410015-6	2006	Src activity was inhibited by Zn2+ treatment of HAEC, consistent with Src-independent EGFR transactivation in HAEC exposed to Zn2+.	Zinc	30-34	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
16410015-6	2006	Src activity was inhibited by Zn2+ treatment of HAEC, consistent with Src-independent EGFR transactivation in HAEC exposed to Zn2+.	Zinc	30-34	epidermal growth factor receptor	Homo sapiens	86-90
16410015-6	2006	Src activity was inhibited by Zn2+ treatment of HAEC, consistent with Src-independent EGFR transactivation in HAEC exposed to Zn2+.	Zinc	126-130	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
16410015-6	2006	Src activity was inhibited by Zn2+ treatment of HAEC, consistent with Src-independent EGFR transactivation in HAEC exposed to Zn2+.	Zinc	126-130	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
16410015-6	2006	Src activity was inhibited by Zn2+ treatment of HAEC, consistent with Src-independent EGFR transactivation in HAEC exposed to Zn2+.	Zinc	126-130	epidermal growth factor receptor	Homo sapiens	86-90
16678130-2	2006	In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation.	Zinc	21-23	amyloid beta precursor protein	Homo sapiens	42-47
16325427-11	2006	Thus for the first time, a strong spatial correlation has been observed between elevated beta-sheet content in Abeta plaques and accumulated Cu and Zn ions, emphasizing an association of metal ions with amyloid formation in AD.	Zinc	148-150	amyloid beta precursor protein	Homo sapiens	111-116
16678130-4	2006	Using fluorescence correlation spectroscopy to resolve the various soluble species of Abeta, we show that low concentrations of Cu(2+) (1 microM) and Zn(2+) (4 microM) selectively eliminate the oligomeric population (within approximately 2h), while Mg(2+) displays a similar effect at a higher concentration (60 microM).	Zinc	150-156	amyloid beta precursor protein	Homo sapiens	86-91
16678130-6	2006	Our results suggest that physiological concentrations of Cu(2+) and Zn(2+) can critically alter the stability of the toxic Abeta oligomers and can potentially control the course of neurodegeneration.	Zinc	68-74	amyloid beta precursor protein	Homo sapiens	123-128
16768444-0	2006	Effect of Zn2+ on DNA recognition and stability of the p53 DNA-binding domain.	Zinc	10-14	tumor protein p53	Homo sapiens	55-58
16648635-4	2006	Treatment of Chinese hamster ovary cells overexpressing amyloid precursor protein with CQ and Cu(2+) or Zn(2+) resulted in an approximately 85-90% reduction of secreted Abeta-(1-40) and Abeta-(1-42) compared with untreated controls.	Zinc	104-106	amyloid beta precursor protein	Homo sapiens	169-174
16768444-3	2006	We have carried out molecular dynamics simulations to investigate the influence of Zn2+ on the p53 DNA recognition and the stability of the DBD.	Zinc	83-87	tumor protein p53	Homo sapiens	95-98
16768444-8	2006	Our results suggest that L2 may be a frustrated and highly flexible element and play an important role in aggregation of Zn-free p53.	Zinc	121-123	tumor protein p53	Homo sapiens	129-132
16440303-5	2006	In this study, we expressed and characterized the recombinant human Cu,Zn-SOD under various concentrations of Cu(2+), Zn(2+), and Cd(2+).	Zinc	71-73	superoxide dismutase 1	Homo sapiens	74-77
16700824-7	2006	The ratios ApoA-1/ApoB, HDL-C/ApoA-1, LDL-C/Apo B, which were closely related to the size of LDL particles, where correlated with Zn/Cu (P&lt;0.001).	Zinc	130-132	apolipoprotein A1	Homo sapiens	11-17
16700824-7	2006	The ratios ApoA-1/ApoB, HDL-C/ApoA-1, LDL-C/Apo B, which were closely related to the size of LDL particles, where correlated with Zn/Cu (P&lt;0.001).	Zinc	130-132	apolipoprotein B	Homo sapiens	18-22
16700824-7	2006	The ratios ApoA-1/ApoB, HDL-C/ApoA-1, LDL-C/Apo B, which were closely related to the size of LDL particles, where correlated with Zn/Cu (P&lt;0.001).	Zinc	130-132	apolipoprotein A1	Homo sapiens	30-36
16700824-7	2006	The ratios ApoA-1/ApoB, HDL-C/ApoA-1, LDL-C/Apo B, which were closely related to the size of LDL particles, where correlated with Zn/Cu (P&lt;0.001).	Zinc	130-132	apolipoprotein B	Homo sapiens	44-49
16704414-6	2006	Similar Zn2+-dependent antibacterial activities were shown for histatin 5 as well as histidine-containing peptides derived from the Zn2+- and heparin-binding domain 5 of human kininogen.	Zinc	8-12	histatin 3	Homo sapiens	63-73
16410015-7	2006	The rate of exogenous EGFR dephosphorylation in lysates of HAEC exposed to Zn2+ or V4+ was significantly diminished.	Zinc	75-79	epidermal growth factor receptor	Homo sapiens	22-26
16410015-8	2006	Moreover, exposure of HAEC to Zn2+ also resulted in a significant impairment of dephosphorylation of endogenous EGFR.	Zinc	30-34	epidermal growth factor receptor	Homo sapiens	112-116
16410015-9	2006	These data show that Zn2+-induced activation of EGFR in HAEC involves a loss of PTP activities whose function is to dephosphorylate EGFR in opposition to baseline EGFR kinase activity.	Zinc	21-25	epidermal growth factor receptor	Homo sapiens	48-52
16410015-9	2006	These data show that Zn2+-induced activation of EGFR in HAEC involves a loss of PTP activities whose function is to dephosphorylate EGFR in opposition to baseline EGFR kinase activity.	Zinc	21-25	epidermal growth factor receptor	Homo sapiens	132-136
16410015-9	2006	These data show that Zn2+-induced activation of EGFR in HAEC involves a loss of PTP activities whose function is to dephosphorylate EGFR in opposition to baseline EGFR kinase activity.	Zinc	21-25	epidermal growth factor receptor	Homo sapiens	132-136
16410015-10	2006	These findings also suggest that there are marked cell-type-specific differences in the mechanism of EGFR activation induced by Zn2+ exposure.	Zinc	128-132	epidermal growth factor receptor	Homo sapiens	101-105
16709200-0	2006	The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply.	Zinc	88-90	metal tolerance protein A2	Arabidopsis thaliana	40-46
16702353-13	2006	A required role for voltage-gated proton channels is demonstrated by Zn(2+) inhibition of NADPH oxidase activity assessed by H(2)O(2) production, thus validating previous studies showing that Zn(2+) inhibited O(2*)(-) production when assessed by cytochrome c reduction.	Zinc	69-75	cytochrome c, somatic	Homo sapiens	246-258
16702353-13	2006	A required role for voltage-gated proton channels is demonstrated by Zn(2+) inhibition of NADPH oxidase activity assessed by H(2)O(2) production, thus validating previous studies showing that Zn(2+) inhibited O(2*)(-) production when assessed by cytochrome c reduction.	Zinc	192-198	cytochrome c, somatic	Homo sapiens	246-258
16709200-0	2006	The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply.	Zinc	140-142	metal tolerance protein A2	Arabidopsis thaliana	40-46
16709200-5	2006	Ectopic over-expression of MTP3 increases Zn accumulation in both roots and rosette leaves of A. thaliana, and enhances Zn tolerance.	Zinc	42-44	metal tolerance protein A2	Arabidopsis thaliana	27-31
16709200-5	2006	Ectopic over-expression of MTP3 increases Zn accumulation in both roots and rosette leaves of A. thaliana, and enhances Zn tolerance.	Zinc	120-122	metal tolerance protein A2	Arabidopsis thaliana	27-31
16709200-6	2006	Exposure of wild-type plants to high but non-toxic concentrations of Zn or Co, or Fe deficiency, strongly induce MTP3 expression specifically in epidermal and cortex cells of the root hair zone.	Zinc	69-71	metal tolerance protein A2	Arabidopsis thaliana	113-117
16709200-7	2006	Silencing of MTP3 by RNA interference causes Zn hypersensitivity and enhances Zn accumulation in above-ground organs of soil-grown plants and of seedlings exposed to excess Zn or to Fe deficiency.	Zinc	45-47	metal tolerance protein A2	Arabidopsis thaliana	13-17
16709200-7	2006	Silencing of MTP3 by RNA interference causes Zn hypersensitivity and enhances Zn accumulation in above-ground organs of soil-grown plants and of seedlings exposed to excess Zn or to Fe deficiency.	Zinc	78-80	metal tolerance protein A2	Arabidopsis thaliana	13-17
16709200-7	2006	Silencing of MTP3 by RNA interference causes Zn hypersensitivity and enhances Zn accumulation in above-ground organs of soil-grown plants and of seedlings exposed to excess Zn or to Fe deficiency.	Zinc	78-80	metal tolerance protein A2	Arabidopsis thaliana	13-17
16709200-8	2006	Our data indicate that, in wild-type A. thaliana, the AtMTP3 protein contributes to basic cellular Zn tolerance and controls Zn partitioning, particularly under conditions of high rates of Zn influx into the root symplasm.	Zinc	99-101	metal tolerance protein A2	Arabidopsis thaliana	54-60
16709200-8	2006	Our data indicate that, in wild-type A. thaliana, the AtMTP3 protein contributes to basic cellular Zn tolerance and controls Zn partitioning, particularly under conditions of high rates of Zn influx into the root symplasm.	Zinc	125-127	metal tolerance protein A2	Arabidopsis thaliana	54-60
16709200-8	2006	Our data indicate that, in wild-type A. thaliana, the AtMTP3 protein contributes to basic cellular Zn tolerance and controls Zn partitioning, particularly under conditions of high rates of Zn influx into the root symplasm.	Zinc	125-127	metal tolerance protein A2	Arabidopsis thaliana	54-60
16373669-0	2006	Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.	Zinc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16546209-2	2006	Human placental lactogen (hPL) is highly conserved with human growth hormone (hGH) and both hormones bind to the hPRLR extracellular domain (ECD), the first step in receptor homodimerization, in a Zn2+-dependent manner.	Zinc	197-201	chorionic somatomammotropin hormone 2	Homo sapiens	6-24
16546209-2	2006	Human placental lactogen (hPL) is highly conserved with human growth hormone (hGH) and both hormones bind to the hPRLR extracellular domain (ECD), the first step in receptor homodimerization, in a Zn2+-dependent manner.	Zinc	197-201	growth hormone 1	Homo sapiens	62-76
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	mitogen-activated protein kinase 1	Homo sapiens	64-67
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	mitogen-activated protein kinase 8	Homo sapiens	69-72
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	mitogen-activated protein kinase 14	Homo sapiens	78-81
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	Zinc	178-184	patatin like phospholipase domain containing 6	Homo sapiens	34-37
16719481-3	2006	The trend in the magnitude of the NTE behavior, with increasing atomic number (Z) of the M(II) ion, follows the order Mn(II) &gt; Fe(II) &gt; Co(II) &gt; Ni(II) &lt; Cu(II) &lt; Zn(II) &lt; Cd(II), which correlates with the trends for M(II) cation size, the lattice parameter, and structural flexibility as indicated by the temperature-dependent structural refinements and Raman spectroscopy.	Zinc	178-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-148
16716083-5	2006	Despite a lower rate and extent of prion protein conversion into altered isoforms, however, Zn(2+) was more efficient than Al(3+) in promoting organization of hPrP aggregates into well-structured, amyloid-like fibrillar filaments, whereas Mn(2+) delayed and Cu(2+) prevented the process.	Zinc	92-94	prion protein	Homo sapiens	159-163
16716083-7	2006	The intrinsic ability of PrP-(82-146)(wt) to form fibrillar aggregates was exalted in the presence of Zn(2+) and, to a lesser extent, of Al(3+), whereas Cu(2+) and Mn(2+) inhibited the conversion of the peptide into amyloid fibrils.	Zinc	102-104	prion protein	Homo sapiens	25-28
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Zinc	210-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-192
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	mitogen-activated protein kinase 8	Homo sapiens	118-121
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
16373669-10	2006	Zn(2+) treatment inhibited ERK- and JNK-directed phosphatase activities in BEAS-2B cells.	Zinc	0-2	mitogen-activated protein kinase 1	Homo sapiens	27-30
16373669-10	2006	Zn(2+) treatment inhibited ERK- and JNK-directed phosphatase activities in BEAS-2B cells.	Zinc	0-2	mitogen-activated protein kinase 8	Homo sapiens	36-39
16373669-11	2006	These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells.	Zinc	29-35	mitogen-activated protein kinase 1	Homo sapiens	105-109
16373669-11	2006	These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells.	Zinc	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
16373669-0	2006	Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.	Zinc	0-4	mitogen-activated protein kinase 8	Homo sapiens	44-47
16373669-0	2006	Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.	Zinc	0-4	mitogen-activated protein kinase 1	Homo sapiens	53-56
16373669-3	2006	In this study, we examined the cellular mechanisms responsible for Zn(2+)-induced IL-8 expression.	Zinc	67-69	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
16373669-4	2006	Zn(2+) stimulation resulted in pronounced increases in both IL-8 mRNA and protein expression in the human airway epithelial cell line (BEAS-2B).	Zinc	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16634581-7	2006	The other metal ion in these heterobimetallic derivatives [Co(II) or Zn(II)] is tetracoordinate and is bound in an eta(1)-N(1) fashion.	Zinc	69-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
16771675-1	2006	Activation of the enzyme Cu,Zn-superoxide dismutase (SOD1) involves several posttranslational modifications including copper and zinc binding, as well as formation of the intramolecular disulfide bond.	Zinc	28-30	superoxide dismutase 1	Homo sapiens	53-57
16614402-6	2006	Negative effects of Zn supplementation on Fe absorption were associated with increased small intestine Fe retention, decreased hephaestin, and increased FPN expression.	Zinc	20-22	solute carrier family 40 member 1	Rattus norvegicus	153-156
16484283-6	2006	Pb2+ treatment triggered the activation of JNK and p38, measured as the phosphorylation of JNK and p38, only in cells incubated in the Zn-deficient media.	Zinc	135-137	mitogen-activated protein kinase 8	Homo sapiens	43-46
16614402-8	2006	Although FPN protein level was lower in Zn-supplemented pups, hephaestin protein level was increased, which may have facilitated enhanced Fe efflux.	Zinc	40-42	solute carrier family 40 member 1	Rattus norvegicus	9-12
16698551-2	2006	Here, we present high-resolution crystal structures of DDAH isoform 1 (DDAH-1) isolated from bovine brain in complex with different inhibitors, including S-nitroso-L-homocysteine and Zn2+, a regulator of this mammalian enzyme.	Zinc	183-187	dimethylarginine dimethylaminohydrolase 1	Bos taurus	55-69
16698551-2	2006	Here, we present high-resolution crystal structures of DDAH isoform 1 (DDAH-1) isolated from bovine brain in complex with different inhibitors, including S-nitroso-L-homocysteine and Zn2+, a regulator of this mammalian enzyme.	Zinc	183-187	dimethylarginine dimethylaminohydrolase 1	Bos taurus	71-77
16484283-6	2006	Pb2+ treatment triggered the activation of JNK and p38, measured as the phosphorylation of JNK and p38, only in cells incubated in the Zn-deficient media.	Zinc	135-137	mitogen-activated protein kinase 14	Homo sapiens	51-54
16484283-8	2006	Results show that Zn deficiency can increase the cytotoxicity of Pb2+ and the susceptibility of neurons to Pb2+-induced oxidative stress, leading to JNK and p38 phosphorylation and, subsequently, AP-1 activation.	Zinc	18-20	mitogen-activated protein kinase 8	Homo sapiens	149-152
16484283-8	2006	Results show that Zn deficiency can increase the cytotoxicity of Pb2+ and the susceptibility of neurons to Pb2+-induced oxidative stress, leading to JNK and p38 phosphorylation and, subsequently, AP-1 activation.	Zinc	18-20	mitogen-activated protein kinase 14	Homo sapiens	157-160
16608305-6	2006	This result supports that the positive guanidinium plays a role in the catalytic mechanism of Cu,Zn-SOD by ensuring that superoxide enters and peroxide leaves rapidly from the coordination sphere of the copper ion.	Zinc	97-99	superoxide dismutase 1	Homo sapiens	100-103
16605251-1	2006	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of two homologous domains (N and C), each bearing a Zn-dependent active site.	Zinc	148-150	angiotensin I converting enzyme	Homo sapiens	0-31
16605251-1	2006	Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of two homologous domains (N and C), each bearing a Zn-dependent active site.	Zinc	148-150	angiotensin I converting enzyme	Homo sapiens	33-36
16585534-4	2006	SMP30 purified from the rat liver had lactonase activity toward various aldonolactones, such as d- and l-glucono-delta-lactone, d- and l-gulono-gamma-lactone, and d- and l-galactono-gamma-lactone, with a requirement for Zn(2+) or Mn(2+) as a cofactor.	Zinc	220-222	regucalcin	Rattus norvegicus	0-5
16489135-11	2006	Plants of Arabidopsis and Lotus accumulated (h)PCs only in response to a large excess of Cu2+ and Zn2+, but to a much lower extent than did with Cd2+, indicating that (h)PC synthesis does not significantly contribute in vivo to copper, zinc, and iron detoxification.	Zinc	98-102	PCS	Homo sapiens	47-50
16483601-10	2006	Cooperative effects on Zn(II) affinities stemming from these finger-finger interactions are observed also in calorimetric studies, in which the 160(+/-20)nM (zf1) and 250(+/-40)nM (zf2) K(d) values for each individual finger increased substantially in the context of the zf1-2 protein (apparent K(dzf1-2WT)=4.6(+/-1.2)nM).	Zinc	23-25	protein arginine methyltransferase 1	Danio rerio	271-274
16483601-11	2006	On the basis of the above observations, we propose a mechanism for Zap1 transcriptional regulation in which zf1-zf2 interactions stabilize the betabetaalpha folded "repressed state" of the zf2 activation domain in the presence of cellular Zn(II) excess.	Zinc	239-245	protein arginine methyltransferase 1	Danio rerio	108-111
16483601-12	2006	Moreover, in contrast to earlier reports of &lt;&lt;1 labile zinc ion/Escherichia coli cell, the zf1-zf2 zinc affinities determined calorimetrically are consistent with Zn(II) levels &gt;&gt;1 labile zinc ion/eukaryotic cell.	Zinc	169-175	protein arginine methyltransferase 1	Danio rerio	97-100
16483601-10	2006	Cooperative effects on Zn(II) affinities stemming from these finger-finger interactions are observed also in calorimetric studies, in which the 160(+/-20)nM (zf1) and 250(+/-40)nM (zf2) K(d) values for each individual finger increased substantially in the context of the zf1-2 protein (apparent K(dzf1-2WT)=4.6(+/-1.2)nM).	Zinc	23-25	protein arginine methyltransferase 1	Danio rerio	158-161
16406071-5	2006	These data represent the first atomic-resolution structures for human SOD1, the first structure of a reduced SOD1, and the first structure of a fully Zn-substituted SOD1 enzyme.	Zinc	150-152	superoxide dismutase 1	Homo sapiens	70-74
16343939-8	2006	Electrophoretic mobility shift assay with double-stranded DNA containing the double Egr1 consensus site 5"-GCG-TGG-GCG-3" confirmed that 6HIS-ZN-wt1 has higher DNA binding affinity than 6HIS-ZN+wt1.	Zinc	142-144	WT1 transcription factor	Homo sapiens	145-148
16343939-8	2006	Electrophoretic mobility shift assay with double-stranded DNA containing the double Egr1 consensus site 5"-GCG-TGG-GCG-3" confirmed that 6HIS-ZN-wt1 has higher DNA binding affinity than 6HIS-ZN+wt1.	Zinc	142-144	WT1 transcription factor	Homo sapiens	194-197
16343939-8	2006	Electrophoretic mobility shift assay with double-stranded DNA containing the double Egr1 consensus site 5"-GCG-TGG-GCG-3" confirmed that 6HIS-ZN-wt1 has higher DNA binding affinity than 6HIS-ZN+wt1.	Zinc	191-193	WT1 transcription factor	Homo sapiens	145-148
16406071-6	2006	Recombinantly expressed as-isolated SOD1 contains a mixture of Zn and Cu at the Cu-binding site.	Zinc	63-65	superoxide dismutase 1	Homo sapiens	36-40
16514189-7	2006	To do this, oocyte extracts were assessed for nuclease activity by a plasmid degradation assay and by zymography; these analyses evidenced a 33 kDa, Ca2+/Mg2+ dependent DNase I-like activity that was inhibited by Zn2+.	Zinc	213-217	deoxyribonuclease 1	Sus scrofa	169-176
16282523-2	2006	We reported that ACE inhibitors directly activate bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in endothelial cells.	Zinc	90-94	angiotensin I converting enzyme	Homo sapiens	17-20
16282523-2	2006	We reported that ACE inhibitors directly activate bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in endothelial cells.	Zinc	90-94	bradykinin receptor B1	Homo sapiens	50-72
16375856-1	2006	Mutations in Cu/Zn superoxide dismutase (SOD) are involved in some cases of familial amyotrophic lateral sclerosis, and it appears that misfolding and aggregation, perhaps mediated by abnormal binding or loss of copper (Cu) and/or zinc (Zn), may play a pathological role.	Zinc	16-18	superoxide dismutase 1	Homo sapiens	41-44
16380093-7	2006	Decorin interacted with mature myostatin in the presence of concentrations of Zn(2+) greater than 10microM, but not in the absence of Zn(2+).	Zinc	78-80	myostatin	Homo sapiens	31-40
16446456-1	2006	Crystals that are likely rhombohedral of Zn-insulin hexamers form in the islets of Langerhans in the pancreases of many mammals.	Zinc	41-43	insulin	Homo sapiens	44-51
16446456-8	2006	We demonstrate for the crystallization of Zn-insulin a mechanism of kink generation whereby 2D clusters of several insulin molecules preformed on the terraces between steps associate to the steps.	Zinc	42-44	insulin	Homo sapiens	45-52
16446456-8	2006	We demonstrate for the crystallization of Zn-insulin a mechanism of kink generation whereby 2D clusters of several insulin molecules preformed on the terraces between steps associate to the steps.	Zinc	42-44	insulin	Homo sapiens	115-122
16375856-3	2006	Here, the individual contributions of Cu and Zn to the kinetic stability of SOD were investigated, and the results show that Cu plays a greater role.	Zinc	45-47	superoxide dismutase 1	Homo sapiens	76-79
16375856-4	2006	Thus, the deficiency of Cu or Zn, especially the former, will compromise the kinetic stability of SOD, thereby increasing the probability that pathogenic mutants and even the WT protein may misfold and self-assemble into toxic species.	Zinc	30-32	superoxide dismutase 1	Homo sapiens	98-101
15916807-2	2006	Several different proteomic functions have been suggested for Ro52, including DNA binding, protein interactions and Zn(2+)-binding.	Zinc	116-122	tripartite motif containing 21	Homo sapiens	62-66
16266835-0	2006	Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer"s disease.	Zinc	33-37	amyloid beta precursor protein	Homo sapiens	80-85
16266835-3	2006	We have used 1H NMR and CD to probe the binding of Zn2+ to Abeta(1-28).	Zinc	51-55	amyloid beta precursor protein	Homo sapiens	59-64
16266835-4	2006	Zinc binding to Abeta causes a number of 1H NMR resonances to exhibit intermediate exchange broadening upon Zn2+ addition, signals in slow and fast exchange are also observed.	Zinc	108-112	amyloid beta precursor protein	Homo sapiens	16-21
16266835-6	2006	Perturbations in specific 1H NMR resonances between residues 6 and 14, and analysis of various Abeta analogues in which each of the three His residues have been replaced by alanine, indicates that His6, His13 and His14 residues are implicated in Zn-Abeta binding.	Zinc	246-248	amyloid beta precursor protein	Homo sapiens	249-254
16266835-8	2006	Binding monitored at Val12 indicates a 1:1 stoichiometry with Abeta for both Zn2+ and Cd2+ ions.	Zinc	77-81	amyloid beta precursor protein	Homo sapiens	62-67
16423513-5	2006	Zn(2+) release ratio depends not only on the pH of the simulated uterine solution but also the presence of human serum albumin.	Zinc	0-6	albumin	Homo sapiens	113-126
16509337-5	2006	The binding capacities of HAs and strengths of metal ion-HA complexes followed the order Pb(II) &gt; Cu(II) &gt; Cd(II) &gt; Zn(II).	Zinc	125-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	89-95
17497012-3	2006	Metallophthalocyanines were able to induce the DNA modification: phthalocyanines of Zn(II) and Al(III) were active as photosensitizers in the generation of singlet oxygen (1)O(2), while phthalocyanine of Co(II) promoted DNA oxidation by molecular oxygen through the catalysis of formation of reactive oxygen species ((.	Zinc	84-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-210
15978864-1	2006	2-(5-Methyl-1H-benzimidazol-2-yl)-4-bromo/nitro-phenols (HLBr and HLNO2) and their Zn(II) complexes with ZnX2 (X = Cl, I, NO3) were synthesized and characterized by elemental analysis, molar conductivity, IR, 1H and 13C NMR spectra.	Zinc	83-85	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
15978864-4	2006	HLBr gives harder complexation reaction with Zn(II) according to HLNO2 because of the stronger intramolecular hydrogen bonding in HLBr, and the both ligands react easier with Zn(NO3)2 than ZnCl2 and ZnI2.	Zinc	45-47	NBL1, DAN family BMP antagonist	Homo sapiens	178-181
16701860-1	2006	Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as beta(2)-microglobulin (beta(2)-MG) as model proteins.	Zinc	17-19	albumin	Homo sapiens	173-186
16892341-4	2006	Docking of 11 into a model structure of ECE revealed a unique binding mode in which the Zn center of the enzyme is not directly addressed by the inhibitor, but key interactions are suggested for the central amide group.	Zinc	88-90	endothelin converting enzyme 1	Rattus norvegicus	40-43
16388104-10	2006	Zn increased on d 1 and 2, and Fe increased on d 2.	Zinc	0-2	deiodinase, iodothyronine, type I	Mus musculus	16-25
16388104-14	2006	Zn increased on d 1 and 2, whereas Fe remained unchanged until d 7, when it decreased.	Zinc	0-2	deiodinase, iodothyronine, type I	Mus musculus	16-25
16307684-5	2005	RESULTS: Liver and erythrocyte CCS expression was significantly (P &lt; 0.05) increased in rats fed the Zn-60 and/or Zn-120 diet compared to rats fed normal levels of Zn (Zn-30).	Zinc	104-106	copper chaperone for superoxide dismutase	Rattus norvegicus	31-34
16137706-3	2005	At significance level p&lt;0.05, in diabetic heart the activities of Cu,Zn-SOD and CAT were elevated as compared to control values (by 60.7% and 55.3% for Cu,Zn-SOD, and by 89.7% and 77.4% for CAT after 4 and 8 weeks, respectively).	Zinc	158-160	catalase	Oryctolagus cuniculus	83-86
16286684-9	2005	Transferrin saturation in the -Fe and -Zn-Fe groups was significantly lower than the Cont group (p &lt; 0.01), and that of the -Zn group was highest among all groups.	Zinc	39-41	transferrin	Rattus norvegicus	0-11
15955728-4	2005	The molar conductance data reveal that Fe(III) and Co(II), Ni(II) and UO2(II) chelates are ionic in nature and are of the type 3:1 and 2:1 electrolytes, respectively, while Cu(II) and Zn(II) complexes are non-electrolytes.	Zinc	184-190	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-57
17205988-1	2006	The relationship between the renin-angiotensin-aldosterone system and insulin concentration and selected zinc (Zn) metabolism parameters and arterial blood pressure in young healthy subjects of both sexes is presented in this study.	Zinc	111-113	renin	Homo sapiens	29-34
17205988-1	2006	The relationship between the renin-angiotensin-aldosterone system and insulin concentration and selected zinc (Zn) metabolism parameters and arterial blood pressure in young healthy subjects of both sexes is presented in this study.	Zinc	111-113	insulin	Homo sapiens	70-77
17205988-4	2006	The results led us to conclude that there is a gender-independent functional relation between Zn homeostasis and the renin-angiotensin-aldosterone system.	Zinc	94-96	renin	Homo sapiens	117-122
16359185-8	2005	Quantifying the ESI-MS data allowed for a relative affinity value between Zn2+ and Au1+ ions to be calculated and shows Au1+ has a 4-fold higher affinity for Sp1-3 than Zn2+.	Zinc	74-78	Sp1 transcription factor	Homo sapiens	158-163
16359185-9	2005	Mechanistic differences between Zn2+ and Au1+ binding to the model Sp1-3 zinc finger were analyzed at isotopic resolution, and the metal-coordination spheres were probed with small molecules (H+, hydrogen peroxide, glutathione disulfide, and iodoacetamide).	Zinc	32-36	Sp1 transcription factor	Homo sapiens	67-72
16359185-12	2005	Circular dichroism (CD) exhibited differences in the secondary structure of the Sp1-3 model peptide when binding Zn2+ or Au1+ ions.	Zinc	113-117	Sp1 transcription factor	Homo sapiens	80-85
16307684-5	2005	RESULTS: Liver and erythrocyte CCS expression was significantly (P &lt; 0.05) increased in rats fed the Zn-60 and/or Zn-120 diet compared to rats fed normal levels of Zn (Zn-30).	Zinc	117-119	copper chaperone for superoxide dismutase	Rattus norvegicus	31-34
16307684-5	2005	RESULTS: Liver and erythrocyte CCS expression was significantly (P &lt; 0.05) increased in rats fed the Zn-60 and/or Zn-120 diet compared to rats fed normal levels of Zn (Zn-30).	Zinc	117-119	copper chaperone for superoxide dismutase	Rattus norvegicus	31-34
16307684-6	2005	Erythrocyte CCS expression was the most sensitive measure of reduced Cu status and was able to detect a decrease in Cu nutriture in rats fed only twice the recommended amount of Zn.	Zinc	178-180	copper chaperone for superoxide dismutase	Rattus norvegicus	12-15
16307684-10	2005	CONCLUSION: Collectively, these data show that CCS is a sensitive measure of Zn-induced mild Cu deficiency and demonstrate a dose-dependent biphasic response for reduced Cu status by moderately high intakes of Zn.	Zinc	77-79	copper chaperone for superoxide dismutase	Rattus norvegicus	47-50
16307684-10	2005	CONCLUSION: Collectively, these data show that CCS is a sensitive measure of Zn-induced mild Cu deficiency and demonstrate a dose-dependent biphasic response for reduced Cu status by moderately high intakes of Zn.	Zinc	210-212	copper chaperone for superoxide dismutase	Rattus norvegicus	47-50
15980035-0	2005	p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.	Zinc	113-117	mitogen-activated protein kinase 14	Homo sapiens	0-3
16199054-3	2005	In this study, we investigated the effects of the biologically relevant thiol-disulphide redox molecule, glutathione, and Zn2+-binding on the oxidative folding of yeast mitochondrial Tim10 using both biochemical and biophysical methods in vitro.	Zinc	122-126	protein transporter TIM10	Saccharomyces cerevisiae S288C	183-188
16199054-7	2005	However, we found that Zn2+-binding can stabilize the reduced Tim10, decreasing the rate of the oxidative folding more than tenfold.	Zinc	23-27	protein transporter TIM10	Saccharomyces cerevisiae S288C	62-67
16199054-8	2005	In addition, we show that protein disulphide isomerase can catalyse the oxidative folding of Tim10 provided that Zn2+ was removed.	Zinc	113-117	protein transporter TIM10	Saccharomyces cerevisiae S288C	93-98
16217140-4	2005	The results showed that Zn deficiency has negative effects on growth, organ weight, and biological parameters such as alkaline phosphatase (ALP) and Cu-Zn superoxide dismutase (Cu-Zn SOD) activities, whereas Zn overload played an effective role in promoting growth, improving the developments of organs and enhancing immune system.	Zinc	24-26	superoxide dismutase 1	Rattus norvegicus	149-175
16217140-4	2005	The results showed that Zn deficiency has negative effects on growth, organ weight, and biological parameters such as alkaline phosphatase (ALP) and Cu-Zn superoxide dismutase (Cu-Zn SOD) activities, whereas Zn overload played an effective role in promoting growth, improving the developments of organs and enhancing immune system.	Zinc	24-26	superoxide dismutase 1	Rattus norvegicus	177-186
16129457-7	2005	It was not possible, however, to transfer to TnaT binding sites for another metal ion, Zn(2+), that we previously engineered in the dopamine (DAT) and GABA (GAT-1) transporters between TM 7 and 8.	Zinc	87-89	solute carrier family 6 member 1	Homo sapiens	157-162
15946124-6	2005	Hsp82 (heat-shock protein 82) has been identified by MS as the main Rpn10/p54-interacting protein, suggesting its role in the reassembly of the 26 S proteasome after Zn2+ removal.	Zinc	166-170	Heat shock protein 83	Drosophila melanogaster	0-5
15946124-6	2005	Hsp82 (heat-shock protein 82) has been identified by MS as the main Rpn10/p54-interacting protein, suggesting its role in the reassembly of the 26 S proteasome after Zn2+ removal.	Zinc	166-170	Heat shock protein 83	Drosophila melanogaster	7-28
16262265-5	2005	Both purified and hyperexpressed tropolysin hydrolyzed bradykinin-derived fluorogenic peptide substrates at restricted sites, with an alkaline pH optimum, and were activated by dithiothreitol and reduced glutathione and by divalent metal cations, in the order Zn(2+) &gt; Co(2+) &gt; Mn(2+).	Zinc	260-266	kininogen 1	Homo sapiens	55-65
15980035-13	2005	These data suggest that p38 and EGFR kinase-mediated Akt activation is required for Zn2+-induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event.	Zinc	84-88	AKT serine/threonine kinase 1	Homo sapiens	53-56
15980035-13	2005	These data suggest that p38 and EGFR kinase-mediated Akt activation is required for Zn2+-induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event.	Zinc	84-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102
16143308-6	2005	YY1 is a zinc finger protein and thus, we hypothesized that NO inhibits YY1 activity via S-nitrosation of critical cysteines residues coordinated by Zn2+.	Zinc	149-153	YY1 transcription factor	Homo sapiens	0-3
16143308-6	2005	YY1 is a zinc finger protein and thus, we hypothesized that NO inhibits YY1 activity via S-nitrosation of critical cysteines residues coordinated by Zn2+.	Zinc	149-153	YY1 transcription factor	Homo sapiens	72-75
16180888-1	2005	Mononuclear Ni(II), Co(II), and Zn(II) complexes of the bppppa (N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(6-pivaloylamido-2-pyridyl)methyl]amine) ligand have been synthesized and characterized by X-ray crystallography, 1H NMR, UV-vis (Ni(II) and Co(II)) and infrared spectroscopy, and elemental analysis.	Zinc	32-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	244-250
16144767-3	2005	The study has shown that the enzyme active site appears to be flexible enough to allow the nucleophilic deactivation reactions of both the (R) and (S) forms of a model of the inhibitor to be catalysed by the Zn(II) cofactor of CPA.	Zinc	208-210	carboxypeptidase A1	Homo sapiens	227-230
15964842-0	2005	Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.	Zinc	28-32	tripartite motif containing 21	Homo sapiens	146-150
15964842-3	2005	Disease-related antibodies bind Ro52 in a conformation-dependent way both in the coiled-coil region and in the Zn2+-binding Ring-B-box region.	Zinc	111-115	tripartite motif containing 21	Homo sapiens	32-36
16055081-8	2005	Zn2+ at 0.2 mM suppressed ConA-induced IL-2 accumulation in the medium of an in vitro culture of Jurkat cells.	Zinc	0-4	interleukin 2	Homo sapiens	39-43
16055081-9	2005	Zn2+ at 0.03-0.3 mM dose-dependently suppressed ConA-induced IL-2 mRNA expression in Jurkat cells.	Zinc	0-4	interleukin 2	Homo sapiens	61-65
16055081-10	2005	Zn2+ also suppressed IL-2 mRNA expression induced by phorbol ester (PMA) and ionomycin.	Zinc	0-4	interleukin 2	Homo sapiens	21-25
16055081-11	2005	Furthermore, Zn2+ and the immunosuppressant FK506 showed an additive inhibitory effect on ConA-induced IL-2 mRNA expression.	Zinc	13-17	interleukin 2	Homo sapiens	103-107
16055081-12	2005	These results suggest that exogenously added Zn2+ may disturb (increase) the intracellular Zn2+ concentration and inhibit CN activity, thereby suppressing IL-2 production in Jurkat cells.	Zinc	45-49	interleukin 2	Homo sapiens	155-159
15963599-12	2005	This study shows that murine KCNQ5 channels, in addition to sharing biophysical and pharmacological characteristics with the human ortholog, are tightly regulated by physiological stimuli such as changes in extracellular Zn2+, pH, and tonicity, thus adding to the complex regulation of these channels.	Zinc	221-225	potassium voltage-gated channel, subfamily Q, member 5	Mus musculus	29-34
15980035-0	2005	p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.	Zinc	113-117	epidermal growth factor receptor	Homo sapiens	8-20
15980035-0	2005	p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.	Zinc	113-117	AKT serine/threonine kinase 1	Homo sapiens	85-88
15980035-3	2005	Exposure to Zn2+ has been associated with activation of multiple intracellular signaling pathways as well as the induction of COX-2 expression.	Zinc	12-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	126-131
15980035-4	2005	This study aims to elucidate the role of intracellular signaling pathways in Zn2+-induced COX-2 expression in human bronchial epithelial cells.	Zinc	77-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	90-95
15980035-5	2005	Inhibitors of the phosphatidylinositol 3-kinase (PI3K) potently block Zn2+-induced COX-2 mRNA and protein expression.	Zinc	70-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
15980035-6	2005	Overexpression of adenoviral constructs encoding dominant-negative Akt kinase downstream of PI3K or wild-type phosphatase and tensin homolog deleted on chromosome 10, an important PI3K phosphatase, suppresses COX-2 mRNA expression induced by Zn2+.	Zinc	242-246	AKT serine/threonine kinase 1	Homo sapiens	67-70
15980035-7	2005	Zn2+ exposure induces phosphorylation of the tyrosine kinases, including Src and EGF receptor (EGFR), and the p38 mitogen-activated protein kinase.	Zinc	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-76
15980035-7	2005	Zn2+ exposure induces phosphorylation of the tyrosine kinases, including Src and EGF receptor (EGFR), and the p38 mitogen-activated protein kinase.	Zinc	0-4	epidermal growth factor receptor	Homo sapiens	81-93
15980035-7	2005	Zn2+ exposure induces phosphorylation of the tyrosine kinases, including Src and EGF receptor (EGFR), and the p38 mitogen-activated protein kinase.	Zinc	0-4	epidermal growth factor receptor	Homo sapiens	95-99
15980035-7	2005	Zn2+ exposure induces phosphorylation of the tyrosine kinases, including Src and EGF receptor (EGFR), and the p38 mitogen-activated protein kinase.	Zinc	0-4	mitogen-activated protein kinase 14	Homo sapiens	110-113
15980035-8	2005	Blockage of these kinases results in inhibition of Zn2+-induced Akt phosphorylation as well as COX-2 protein expression.	Zinc	51-55	AKT serine/threonine kinase 1	Homo sapiens	64-67
15980035-9	2005	Overexpression of dominant negative p38 constructs suppresses Zn2+-induced increase in COX-2 promoter activity.	Zinc	62-66	mitogen-activated protein kinase 14	Homo sapiens	36-39
15980035-9	2005	Overexpression of dominant negative p38 constructs suppresses Zn2+-induced increase in COX-2 promoter activity.	Zinc	62-66	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
15980035-11	2005	Inhibition of p38, Src, and EGFR kinases with pharmacological inhibitors markedly reduces Akt phosphorylation induced by Zn2+.	Zinc	121-125	mitogen-activated protein kinase 14	Homo sapiens	14-17
15980035-11	2005	Inhibition of p38, Src, and EGFR kinases with pharmacological inhibitors markedly reduces Akt phosphorylation induced by Zn2+.	Zinc	121-125	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-22
15980035-11	2005	Inhibition of p38, Src, and EGFR kinases with pharmacological inhibitors markedly reduces Akt phosphorylation induced by Zn2+.	Zinc	121-125	epidermal growth factor receptor	Homo sapiens	28-32
15980035-11	2005	Inhibition of p38, Src, and EGFR kinases with pharmacological inhibitors markedly reduces Akt phosphorylation induced by Zn2+.	Zinc	121-125	AKT serine/threonine kinase 1	Homo sapiens	90-93
15980035-13	2005	These data suggest that p38 and EGFR kinase-mediated Akt activation is required for Zn2+-induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event.	Zinc	84-88	mitogen-activated protein kinase 14	Homo sapiens	24-27
15980035-13	2005	These data suggest that p38 and EGFR kinase-mediated Akt activation is required for Zn2+-induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event.	Zinc	84-88	epidermal growth factor receptor	Homo sapiens	32-36
15792553-3	2005	In vitro characterization of sustained release of human growth hormone (hGH) using this injectable depot shows that hGH remains stable inside the hydrogel formed, and demonstrates more than 2 weeks of prolonged release of hGH complexed with Zn(2+) ions without protein aggregation or initial burst.	Zinc	241-243	growth hormone 1	Homo sapiens	56-70
15947038-4	2005	We also confirmed the inhibition of recombinant GIRK1+GIRK2 heteromultimers by tertiapin-Q, which had no effect on endogenous depolarization- and hyperpolarization-activated currents sensitive to extracellular divalent cations (Ca(2+), Mg(2+), Zn(2+), and Ba(2+)) in defolliculated oocytes.	Zinc	244-246	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	48-53
16078307-6	2005	Abeta1-16 bound one equivalent of Zn(II) with an apparent dissociation constant (Kd) of 10(-4) M. This Kd value is in the same range as the Zn concentration needed to precipitate Abeta.	Zinc	34-36	amyloid beta precursor protein	Homo sapiens	0-5
16005709-11	2005	IFN-alpha treatment also resulted in biphasic increases in hepatic Zn, with levels peaking at 2 h, the time-point when MT levels are first increased, and again at 18 h. Concurrently, there were decreases in serum Zn levels at these time points, suggesting IFN-alpha induced movement of Zn from the blood to hepatic tissue.	Zinc	67-69	interferon alpha 1	Homo sapiens	0-9
16135821-3	2005	(i) The N-terminal Zn ribbon of TFB displays a surprising degree of redundancy for the recruitment of RNAP during transcription initiation in the archaeal system.	Zinc	19-21	general transcription factor IIB	Homo sapiens	32-35
17162855-1	2005	PURPOSE: To investigate whether the induction of heat shock protein (HSP)72 by heat stress (HS) or zinc (Zn2+ ) administration can increase survival of retinal ganglion cells (RGC)in rat model of acute experimental glaucoma.	Zinc	105-109	selenoprotein K	Rattus norvegicus	49-67
16329506-0	2005	[Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+].	Zinc	95-99	albumin	Homo sapiens	28-41
16055450-3	2005	Analysis of NMR structural and dynamic data for an F1-6 protein construct demonstrates that each zinc finger adopts a stable betabetaalpha fold in the presence of stoichiometric Zn(II), provided that all cysteine ligands are in a reduced state.	Zinc	178-180	coagulation factor II, thrombin	Homo sapiens	51-55
16158220-3	2005	In the golgi apparatus, proinsulin is sequestered within Zn(2+)- and Ca(2+)-rich storage/secretory vesicles and assembled into a Zn(2+) and Ca(2+) containing hexameric species, (Zn(2+))(2)(Ca(2+))(Proin)(6).	Zinc	57-63	insulin	Homo sapiens	24-34
16158220-3	2005	In the golgi apparatus, proinsulin is sequestered within Zn(2+)- and Ca(2+)-rich storage/secretory vesicles and assembled into a Zn(2+) and Ca(2+) containing hexameric species, (Zn(2+))(2)(Ca(2+))(Proin)(6).	Zinc	57-59	insulin	Homo sapiens	24-34
16158220-3	2005	In the golgi apparatus, proinsulin is sequestered within Zn(2+)- and Ca(2+)-rich storage/secretory vesicles and assembled into a Zn(2+) and Ca(2+) containing hexameric species, (Zn(2+))(2)(Ca(2+))(Proin)(6).	Zinc	129-135	insulin	Homo sapiens	24-34
16158220-12	2005	The role of Zn(2+) in the assembly, structure, allosteric properties, and dynamic behavior of the insulin hexamer will be discussed in relation to biological function.	Zinc	12-14	insulin	Homo sapiens	98-105
16158222-2	2005	Zinc appears to be an important metal for insulin-secreting cells as insulin is stored inside secretory vesicles as a solid hexamer bound with two Zn(2+) ions per hexamer.	Zinc	147-149	insulin	Homo sapiens	69-76
16005709-11	2005	IFN-alpha treatment also resulted in biphasic increases in hepatic Zn, with levels peaking at 2 h, the time-point when MT levels are first increased, and again at 18 h. Concurrently, there were decreases in serum Zn levels at these time points, suggesting IFN-alpha induced movement of Zn from the blood to hepatic tissue.	Zinc	213-215	interferon alpha 1	Homo sapiens	0-9
16005709-11	2005	IFN-alpha treatment also resulted in biphasic increases in hepatic Zn, with levels peaking at 2 h, the time-point when MT levels are first increased, and again at 18 h. Concurrently, there were decreases in serum Zn levels at these time points, suggesting IFN-alpha induced movement of Zn from the blood to hepatic tissue.	Zinc	213-215	interferon alpha 1	Homo sapiens	0-9
15857947-2	2005	In the present study, the effects of divalent metal ions (Ba(2+), Co(2+), Ni(2+), Pb(2+), and Zn(2+)) were examined on TREK-2 expressed in Xenopus oocytes using the two-electrode voltage clamping technique.	Zinc	94-96	potassium channel, two pore domain subfamily K, member 10 S homeolog	Xenopus laevis	119-125
16096680-3	2005	The Zn(2+)-dependent activity assay of the most active sequence showed that the DNAzyme possesses an apparent Zn(2+)-binding dissociation constant of 234 muM and that its activity increases with increasing temperatures from 50-90 degrees C. A fit of the Arrhenius plot data gave E(a) = 15.3 kcal mol(-1).	Zinc	4-10	latexin	Homo sapiens	154-157
16096680-3	2005	The Zn(2+)-dependent activity assay of the most active sequence showed that the DNAzyme possesses an apparent Zn(2+)-binding dissociation constant of 234 muM and that its activity increases with increasing temperatures from 50-90 degrees C. A fit of the Arrhenius plot data gave E(a) = 15.3 kcal mol(-1).	Zinc	110-116	latexin	Homo sapiens	154-157
15857947-6	2005	The structural element(s) contributing to the zinc enhancement effect were studied using a series of chimeras consisting of Zn(2+)-activated TREK-2 and Zn(2+)-inhibited TWIK-related acid-sensing K(+) channel-3.	Zinc	124-126	potassium channel, two pore domain subfamily K, member 10 S homeolog	Xenopus laevis	141-147
15857947-8	2005	Stimulation by Zn(2+) may be used as a criterion of TREK-2, distinguishing it from other two-pore K(+) channels.	Zinc	15-21	potassium channel, two pore domain subfamily K, member 10 S homeolog	Xenopus laevis	52-58
16115673-2	2005	Zn deficiency-triggered oxidative stress could affect cell signaling, including: (1) transcription factors containing Zn finger motifs, and (2) other oxidant-sensitive transcription factors (NF-kappaB and AP-1).	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	191-200
16099027-4	2005	Zn supplementation attenuates ethanol-induced hepatic Zn depletion and suppresses ethanol-elevated cytochrome P450 2E1 (CYP2E1) activity, but increases the activity of alcohol dehydrogenase in the liver; an action that is likely responsible for Zn suppression of alcohol-induced oxidative stress.	Zinc	0-2	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	99-118
16099027-4	2005	Zn supplementation attenuates ethanol-induced hepatic Zn depletion and suppresses ethanol-elevated cytochrome P450 2E1 (CYP2E1) activity, but increases the activity of alcohol dehydrogenase in the liver; an action that is likely responsible for Zn suppression of alcohol-induced oxidative stress.	Zinc	0-2	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	120-126
16099027-7	2005	Zn supplementation preserves intestinal integrity and prevents endotoxemia, leading to inhibition of endotoxin-induced tumor necrosis factor-alpha (TNF-alpha) production in the liver.	Zinc	0-2	tumor necrosis factor	Homo sapiens	148-157
16099027-8	2005	Zn also directly inhibits the signaling pathway involved in endotoxin-induced TNF-alpha production.	Zinc	0-2	tumor necrosis factor	Homo sapiens	78-87
16099495-2	2005	Three types of SODs are known in humans, with the most abundant being cytosolic SOD1, identified by its Cu, Zn-containing prosthetic group.	Zinc	108-110	superoxide dismutase 1	Homo sapiens	80-84
16115673-6	2005	AP-1 is generally activated in Zn deficiency that can occur secondary to an increase in cellular H(2)O(2), followed by activation of MAPKs p38 and JNK.	Zinc	31-33	mitogen-activated protein kinase 14	Homo sapiens	139-142
16115673-8	2005	The cytosolic steps of the NF-kappaB cascade are activated by oxidants in Zn deficiency.	Zinc	74-76	nuclear factor kappa B subunit 1	Homo sapiens	27-36
16115673-9	2005	However, an impaired nuclear transport of the active transcription factor leads to a low expression of NF-kappaB-dependent genes that could be involved in multiple aspects of Zn deficiency associated pathology.	Zinc	175-177	nuclear factor kappa B subunit 1	Homo sapiens	103-112
16028930-8	2005	Thus, by using a combination of sensor molecules, it was demonstrated for the first time that a higher Zn(2+) concentration is released in DG than in CA3 or CA1 and that we can easily visualize Zn(2+) concentration over a wide range.	Zinc	103-109	carbonic anhydrase 3	Homo sapiens	150-153
16055687-11	2005	While the ionome of cax1 and cax3 lines were modestly perturbed, the cax1/cax3 lines displayed increased PO4(3-), Mn2+, and Zn2+ and decreased Ca2+ and Mg2+ in shoot tissue.	Zinc	124-128	cation exchanger 3	Arabidopsis thaliana	74-78
15997205-9	2005	Most of the secreted activity required Zn+2 for full activity, supporting the concept that intracellular exposure of ASM to zinc within lysosomes is required for enzymatic activation.	Zinc	39-43	sphingomyelin phosphodiesterase 1	Homo sapiens	117-120
16005295-7	2005	Mutation of a single conserved cysteine residue in the predicted Zn binding motif resulted in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn finger is essential for the cleavage of poly-Ub chains.	Zinc	65-67	ubiquitin specific peptidase 15	Homo sapiens	106-111
16005295-7	2005	Mutation of a single conserved cysteine residue in the predicted Zn binding motif resulted in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn finger is essential for the cleavage of poly-Ub chains.	Zinc	174-176	ubiquitin specific peptidase 15	Homo sapiens	106-111
15984876-3	2005	X-ray absorption spectroscopy of Pb(II) bound to structural zinc-binding peptides reveals that Pb(II) binds in a three-coordinate Pb(II)-S(3) mode, while Zn(II) is known to bind in a four-coordinate mode in these proteins.	Zinc	154-160	submaxillary gland androgen regulated protein 3B	Homo sapiens	33-39
16477936-7	2005	The main dissolved trace metals in fog droplets are Zn, Al and Fe, while the main metallic cations are Na and Ca.	Zinc	52-54	zinc finger protein, FOG family member 1	Homo sapiens	35-38
16029032-3	2005	HSA-Fmoc-insulin is water-soluble and, upon incubation in aqueous buffers reflecting normal human serum conditions, slowly, spontaneously, and homogeneously hydrolyzes to release unmodified insulin with a t 1/2 of 25 +/- 2 h. A single subcutaneous or intraperitoneal administration of HSA-Fmoc-insulin to diabetic rodents lowers circulating glucose levels for about 4 times longer than an equipotent dose of Zn2+-free insulin.	Zinc	408-412	insulin	Homo sapiens	9-16
15966733-5	2005	Certain metals (Zn(2+), Pb(2+), and Cu(2+)) induce a partially folded conformation of beta-synuclein that triggers rapid fibrillation.	Zinc	16-22	synuclein beta	Homo sapiens	86-100
15635658-6	2005	The dose-responsive glucose-mediated release of the novel insulins was demonstrated using glucamine-derived polyethylene glycol polyacrylamide (PEGA) as a model, and it was shown that Zn(II) hexamer formulation of the boronated insulins resulted in steeper glucose sensitivity relative to monomeric insulin formulation.	Zinc	184-190	insulin	Homo sapiens	58-65
15961376-5	2005	For the first time, we have observed that factor XII and high-molecular-weight kininogen, constituents of the blood plasma, can bind to VSMC in a Zn2+-dependent manner.	Zinc	146-150	kininogen 1	Homo sapiens	57-88
15763633-1	2005	Effects of Zn2+ on the activity and conformation of cytochorome P450 3A4 (CYP3A4) were investigated.	Zinc	11-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-72
15840828-2	2005	Here we describe in detail the crystal structures of pathogenic H46R SOD1 in the Zn-loaded (Zn-H46R) and metal-free (apo-H46R) forms.	Zinc	81-83	superoxide dismutase 1	Homo sapiens	69-73
15839648-1	2005	The physiological electron-transfer (ET) partners, cytochrome c peroxidase (CcP) and cytochrome c (Cc)1, can be modified to exhibit photoinitiated ET through substitution of Zn (or Mg) for Fe in either partner.	Zinc	174-176	cytochrome c, somatic	Homo sapiens	51-63
15763633-6	2005	These results suggest that the inhibitory effects of Zn2+ come from preventing the stimulation of b5 on CYP3A4 activity.	Zinc	53-57	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-110
15763633-1	2005	Effects of Zn2+ on the activity and conformation of cytochorome P450 3A4 (CYP3A4) were investigated.	Zinc	11-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-80
15763633-2	2005	Zn2+ specifically inhibited the testosterone 6beta-hydroxylation activity of CYP3A4 with an IC50 value of 27 microM.	Zinc	0-4	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
15763633-3	2005	Zn2+ inhibited the CO-binding spectra of CYP3A4 reduced by NADPH-cytochrome P450 reductase (CPR) and NADPH only in the presence of b5.	Zinc	0-4	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
15763633-3	2005	Zn2+ inhibited the CO-binding spectra of CYP3A4 reduced by NADPH-cytochrome P450 reductase (CPR) and NADPH only in the presence of b5.	Zinc	0-4	cytochrome p450 oxidoreductase	Homo sapiens	59-90
15763633-3	2005	Zn2+ inhibited the CO-binding spectra of CYP3A4 reduced by NADPH-cytochrome P450 reductase (CPR) and NADPH only in the presence of b5.	Zinc	0-4	cytochrome p450 oxidoreductase	Homo sapiens	92-95
15763633-4	2005	Zn2+-induced conformational changes of CYP3A4 were monitored by CD and intrinsic fluorescence.	Zinc	0-4	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
15718230-2	2005	We show that Cu(2+) and Zn(2+) but not Fe(3+) renders the amyloid beta peptide, Abeta(1-40), nonfibrillogenic in nature.	Zinc	24-26	amyloid beta precursor protein	Homo sapiens	58-70
15796505-0	2005	Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal.	Zinc	102-106	peptide deformylase	Escherichia coli	22-41
15691827-4	2005	This shedding was inhibited by the broad range metalloproteinase inhibitor GM6001, the two potent ADAM17 inhibitors GW280264X and TAPI-2, and was absent in mice lacking functional ADAM17 (ADAM17 lacking Zn-binding domain; ADAM17(DeltaZn/DeltaZn)).	Zinc	203-205	a disintegrin and metallopeptidase domain 17	Mus musculus	180-186
15691827-4	2005	This shedding was inhibited by the broad range metalloproteinase inhibitor GM6001, the two potent ADAM17 inhibitors GW280264X and TAPI-2, and was absent in mice lacking functional ADAM17 (ADAM17 lacking Zn-binding domain; ADAM17(DeltaZn/DeltaZn)).	Zinc	203-205	a disintegrin and metallopeptidase domain 17	Mus musculus	180-186
15691827-4	2005	This shedding was inhibited by the broad range metalloproteinase inhibitor GM6001, the two potent ADAM17 inhibitors GW280264X and TAPI-2, and was absent in mice lacking functional ADAM17 (ADAM17 lacking Zn-binding domain; ADAM17(DeltaZn/DeltaZn)).	Zinc	203-205	a disintegrin and metallopeptidase domain 17	Mus musculus	180-186
15806612-7	2005	In contrast, deletion of URE2 greatly enhances a cell"s ability to withstand toxic concentrations of Zn(II) and Mo(VI).	Zinc	101-103	glutathione peroxidase	Saccharomyces cerevisiae S288C	25-29
15598842-11	2005	In calcium-free buffer, Zn(2+) reduced the ANG II response by 68%.	Zinc	24-30	angiotensinogen	Rattus norvegicus	43-49
15943174-5	2005	Moreover, 10(-4) and 10(-5) M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release.	Zinc	30-32	interferon gamma	Homo sapiens	70-79
15943174-5	2005	Moreover, 10(-4) and 10(-5) M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release.	Zinc	30-32	tumor necrosis factor	Homo sapiens	206-215
15802826-4	2005	In the present study, we investigated the involvement of caspase-3 in Py (1 microM)/Zn (25 microM)-induced apoptosis in HL-60 cells.	Zinc	84-86	caspase 3	Homo sapiens	57-66
15802826-10	2005	Taken together, these results indicate that the activation of caspase-3 is partly responsible for the induction of apoptosis in Py/Zn-treated HL-60 cells.	Zinc	131-133	caspase 3	Homo sapiens	62-71
15778228-5	2005	UL84 UTPase was the highest at low salt concentrations, a pH of 7.5, and a temperature of 45 degrees C. The enzyme preferred Mg2+ as the divalent cation but was also able to catalyze the UTPase reaction in the presence of Mn2+, Ca2+, and Zn2+ albeit at lower levels.	Zinc	238-242	protein UL84	Human betaherpesvirus 5	0-4
15964699-4	2005	Consistently, Tat potentiated currents of the particularly Zn(2+)-sensitive NR1/NR2A NMDA receptor with a higher efficacy, whereas currents from a Zn(2+)-insensitive mutant were only marginally augmented.	Zinc	59-61	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	76-79
15788127-7	2005	CONCLUSIONS: The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn, Cu and of nuclear DNA, Zn and Cu are not only the substance base on which the lesion of gastric mucosa tissue structure occurs, but also the substance base on which spleen deficiency is classified.	Zinc	93-95	cathelicidin antimicrobial peptide	Homo sapiens	57-61
15788127-7	2005	CONCLUSIONS: The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn, Cu and of nuclear DNA, Zn and Cu are not only the substance base on which the lesion of gastric mucosa tissue structure occurs, but also the substance base on which spleen deficiency is classified.	Zinc	93-95	cathelicidin antimicrobial peptide	Homo sapiens	57-61
15721369-4	2005	Using APOBEC3G deletion and point mutants, we mapped the encapsidation determinant to the Zn(2+) coordination residues of the N-terminal catalytic domain (CD1).	Zinc	90-92	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	6-14
15699167-5	2005	Our data further suggest that the zinc metal center plays a role in forming and/or stabilizing iNOS undisruptable dimers (UD-dimers).	Zinc	34-44	nitric oxide synthase 2	Homo sapiens	95-99
15551063-9	2005	Effects of Zn(2+) on bcl-2/bax ratio were confirmed in apoptotic camptothecin-treated SHE cells.	Zinc	11-13	apoptosis regulator Bcl-2	Mesocricetus auratus	21-26
15703331-6	2005	Our results provide evidence that levels of zinc, manganese and the amount of MMP-3 in saliva are significantly decreased in the patients with taste disorder compared to the healthy subjects; Zn (p.p.b.	Zinc	192-194	matrix metallopeptidase 3	Homo sapiens	78-83
15654764-2	2005	When using nitrocefin as the substrate, time-dependent absorption spectra demonstrate that Co(II)-substituted L1 utilizes a reaction mechanism, similar to that of the native Zn(II) enzyme, in which a short-lived intermediate forms.	Zinc	174-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
15593132-0	2005	Metal-binding properties of the peptide APP170-188: a model of the ZnII-binding site of amyloid precursor protein (APP).	Zinc	67-71	amyloid beta precursor protein	Homo sapiens	88-113
15641773-5	2005	In marked contrast to this result, we find that both the CBP and p300 TAZ domains in the presence of stoichiometric concentrations of Zn(2+) adopt a well-defined structure in solution in the absence of binding partners.	Zinc	134-136	CREB binding protein	Homo sapiens	57-60
15850220-6	2005	So, ions of Co2+, Cd2+, Zn2+ and Ni2+ but not Fe2+ significantly influence the dynamics of thrombin-induced clot formation and optical clot characteristics.	Zinc	24-28	coagulation factor II, thrombin	Homo sapiens	91-99
16179752-3	2005	In Zn-exposed cells, mitochondria released cytochrome c and AIF, whose translocation to the cytoplasm or the nucleus coincided with the activation of apoptosis.	Zinc	3-5	cytochrome c, somatic	Homo sapiens	43-55
15865262-7	2005	Interestingly, Zn treatment to protein-deficient animals lowered already raised activity catalase, glutathione peroxidase, and glutathione-S-transferase and levels of lipid peroxidation to significant levels when compared to protein-deficient animals.	Zinc	15-17	catalase	Rattus norvegicus	89-97
15966572-14	2005	Both Zn and Se were negatively correlated to cTnT, and Se was also to cTnI.	Zinc	5-7	troponin T2, cardiac type	Homo sapiens	45-49
15595835-1	2004	Site-directed mutagenesis and design of Zn(2+)-binding centers have been used to determine a set of specific tertiary interactions between the mu-opioid receptor, a rhodopsin-like G protein-coupled receptor (GPCR), and its cyclic peptide agonist ligand, Tyr(1)-c(S-Et-S)[d-Cys(2)-Phe(3)-d-Pen(4)]NH(2) (JOM6).	Zinc	40-42	rhodopsin	Homo sapiens	165-174
15669313-7	2004	In the presence of As(V), Zn sorption on goethite increased by 800 and 1300% at pH 4 and 7, respectively.	Zinc	26-28	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-24
15669313-11	2004	Below As(V) surface saturation on goethite, As(V) formed bidentate binuclear bridging complexes on Fe and/or Zn octahedra, while Zn mainly formed edge-sharing complexes with Fe at the goethite surface.	Zinc	109-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-49
15355987-4	2004	We demonstrate that Ca2+ release, mediated by the ZnR, induces phosphorylation of ERK1/2, which is highly metal-specific, mediated by physiological concentrations of extracellular Zn2+ but not by Cd2+, Fe2+, Ni2+, or Mn2+.	Zinc	180-184	mitogen-activated protein kinase 3	Homo sapiens	82-88
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	30-34	mitogen-activated protein kinase 3	Homo sapiens	103-109
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	30-34	mitogen-activated protein kinase 3	Homo sapiens	202-208
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	87-91	mitogen-activated protein kinase 3	Homo sapiens	103-109
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	87-91	mitogen-activated protein kinase 3	Homo sapiens	202-208
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	87-91	mitogen-activated protein kinase 3	Homo sapiens	103-109
15355987-5	2004	Desensitization of the ZnR by Zn2+, is followed by approximately 90% inhibition of the Zn2+ -dependent ERK1/2 phosphorylation, indicating that the ZnR is a principal link between extracellular Zn2+ and ERK1/2 activation.	Zinc	87-91	mitogen-activated protein kinase 3	Homo sapiens	202-208
15355987-6	2004	Application of both the IP3 pathway and PI 3-kinase antagonists largely inhibited Zn2+ -dependent ERK1/2 phosphorylation.	Zinc	82-86	mitogen-activated protein kinase 3	Homo sapiens	98-104
15355987-7	2004	The physiological significance of the Zn2+ -dependent activation of ERK1/2 was addressed by monitoring Na+/H+ exchanger activity in HT29 cells and in native colon epithelium.	Zinc	38-42	mitogen-activated protein kinase 3	Homo sapiens	68-74
15355987-10	2004	Prolonged acidification, in contrast, stimulates NHE1 by a distinct pathway that is not affected by extracellular Zn2+ or inhibitors of the MAP kinase pathway.	Zinc	114-118	solute carrier family 9 member A1	Homo sapiens	49-53
15322118-2	2004	In this study, we present evidence that mouse Zip5 is a zinc uptake transporter that is specific for Zn(II) over other potential metal ion substrates.	Zinc	101-107	solute carrier family 39 (metal ion transporter), member 5	Mus musculus	46-50
15506727-2	2004	Sonication of 5 mum Zn powder as a slurry in alkanes, for example, produces dense agglomerates 50 mum in diameter consisting of approximately 1000 fused particles.	Zinc	20-22	latexin	Homo sapiens	16-19
15506727-2	2004	Sonication of 5 mum Zn powder as a slurry in alkanes, for example, produces dense agglomerates 50 mum in diameter consisting of approximately 1000 fused particles.	Zinc	20-22	latexin	Homo sapiens	98-101
15582280-1	2004	A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer"s amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis.	Zinc	87-89	amyloid beta precursor protein	Homo sapiens	127-132
15451416-8	2004	Furthermore, ZnT-1 may play a role in cellular ion homeostasis and thereby confer protection against pathophysiological events linked to cellular Ca(2+) or Zn(2+) permeation and cell death.	Zinc	156-162	solute carrier family 30 member 1	Homo sapiens	13-18
15516700-8	2004	Hence, both Cr and Zn were found to have insulin mimetic activity.	Zinc	19-21	insulin	Homo sapiens	41-48
15516700-12	2004	Therefore, both Zn and Cr seem to have a positive effect on insulin signaling leading to glucose uptake.	Zinc	16-18	insulin	Homo sapiens	60-67
15590070-3	2004	The GSNO related S-nitrosylation of the conserved C-terminal cysteine is strongly activated by the binding of Ca(II) to S100A1 and of Ca(II) and Zn(II) to S100B.	Zinc	145-151	S100 calcium binding protein B	Homo sapiens	155-160
15597541-4	2004	Zn2+, which is co-released with insulin, reacts with extracellular FluoZin-3 to form a fluorescent product.	Zinc	0-4	insulin	Homo sapiens	32-39
15564445-3	2004	We hypothesized that Zn(2+) may affect NF-kappa B, which may play a key role in immune-mediated diabetogenesis.	Zinc	21-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-49
15564445-7	2004	Zn(2+) significantly stimulated NF-kappa B and AP-1 activation in NOD mice, in contrast, in C57BL/6 mice, Zn(2+) significantly reduced their activation by MLD-STZ.	Zinc	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-42
15564445-9	2004	Depending on the mode of beta-cell destruction, Zn(2+) may prevent apoptosis through activation of NF-kappa B in NOD mice or prevent inflammatory immune destruction through inhibition of NF-kappa B in MLD-STZ-treated C57BL/6 mice.	Zinc	48-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-109
15564445-9	2004	Depending on the mode of beta-cell destruction, Zn(2+) may prevent apoptosis through activation of NF-kappa B in NOD mice or prevent inflammatory immune destruction through inhibition of NF-kappa B in MLD-STZ-treated C57BL/6 mice.	Zinc	48-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	187-197
15535990-8	2004	Interestingly, when Zn was supplemented to nickel treated rats, the activities of catalase, and glutathione-S-transferase and the levels of GSH and lipid peroxidation came back to within normal limits.	Zinc	20-22	catalase	Rattus norvegicus	82-90
15510264-5	2004	All these dinuclear species show a great tendency to add the OH(-) group: the equilibrium constant for the addition reaction was found to be logK(M(2)LH(-1)OH)= 4.77 for Cu(II), 5.66 for Zn(II), 2.8 for Cd(II) and 3.18 for Pb(II).	Zinc	187-189	submaxillary gland androgen regulated protein 3B	Homo sapiens	223-229
15540943-0	2004	Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity.	Zinc	33-39	XPA, DNA damage recognition and repair factor	Homo sapiens	95-98
15540943-3	2004	To study the possible molecular mechanisms of XPA inhibition, we previously investigated Zn(II) and Ni(II) interactions with the synthetic 37 amino acid peptide (XPAzf), AcDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKam, representing the XPA zinc finger sequence (Bal, W., Schwerdtle, T., and Hartwig, A.	Zinc	89-91	XPA, DNA damage recognition and repair factor	Homo sapiens	162-165
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Zinc	191-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-11	2004	The conditional binding constants determined for Co(II) and Cd(II) in 50 mM phosphate buffer, pH 7.4, are 10(7.4)+/-(0.4) and 10(12.8)+/-(0.5), respectively, yielding binding constant ratios Zn(II)/Co(II) of 100 and Zn(II)/ Cd(II) of 0.001, which are the lowest values reported for zinc fingers so far.	Zinc	191-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-88
15540943-14	2004	The oxidation of Zn(II)-saturated XPAzf by H2O2 is accelerated in the presence of Co(II), but the concentration profile of this effect indicates the formation of an active Co(II) complex external to the metal-sulfur center.	Zinc	17-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-178
15672649-6	2004	Zn treatment to protein deficient animals lowered lipid peroxidation and catalase, Gpx and GST activities, and also resulted in a significant elevation in the levels of GSH and SOD activity.	Zinc	0-2	catalase	Rattus norvegicus	73-81
15360262-0	2004	An unsymmetrical tripodal ligand with NOS2-donor set: coordination chemistry with nickel(II) and zinc(II).	Zinc	97-105	nitric oxide synthase 2	Homo sapiens	38-42
15113746-9	2004	In ATP-depleted cells, Zn(2+) partially prevented Bax activation and cytochrome c release from mitochondria.	Zinc	23-29	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
15113746-9	2004	In ATP-depleted cells, Zn(2+) partially prevented Bax activation and cytochrome c release from mitochondria.	Zinc	23-29	cytochrome c, somatic	Homo sapiens	69-81
15113746-10	2004	In isolated cell cytosol, Zn(2+) blocked cytochrome c-stimulated caspase activation at low-micromolar concentrations.	Zinc	26-32	cytochrome c, somatic	Homo sapiens	41-53
15113746-13	2004	Zn(2+) blocks apoptosis at multiple steps including Bax activation, cytochrome c release, apoptosome function, and caspase activation.	Zinc	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
15113746-13	2004	Zn(2+) blocks apoptosis at multiple steps including Bax activation, cytochrome c release, apoptosome function, and caspase activation.	Zinc	0-2	cytochrome c, somatic	Homo sapiens	68-80
15276032-3	2004	The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)&gt;Zn(II) &gt;&gt;Ni(II)&gt;Co(II).	Zinc	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-135
15367699-4	2004	Disulfiram given to melanoma cells in combination with Cu2+ or Zn2+ decreased expression of cyclin A and reduced proliferation in vitro at lower concentrations than disulfiram alone.	Zinc	63-67	cyclin A2	Homo sapiens	92-100
15322227-0	2004	COX-2 Regulates the insulin-like growth factor I-induced potentiation of Zn(2+)-toxicity in primary cortical culture.	Zinc	73-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15322227-0	2004	COX-2 Regulates the insulin-like growth factor I-induced potentiation of Zn(2+)-toxicity in primary cortical culture.	Zinc	73-79	insulin like growth factor 1	Homo sapiens	20-48
15322227-2	2004	In the current study, we investigated the mechanism underlying the insulin-like growth factor-I (IGF-I)-induced Zn(2+) toxicity potentiation.	Zinc	112-114	insulin like growth factor 1	Homo sapiens	67-95
15322227-2	2004	In the current study, we investigated the mechanism underlying the insulin-like growth factor-I (IGF-I)-induced Zn(2+) toxicity potentiation.	Zinc	112-114	insulin like growth factor 1	Homo sapiens	97-102
15322227-3	2004	The pretreatment of primary cortical cultures for more than 12 h with 100 ng/ml of IGF-I increased the cytotoxicity induced by 80 microM Zn(2+) by more than 2-fold.	Zinc	137-139	insulin like growth factor 1	Homo sapiens	83-88
15322227-10	2004	These results suggest that COX-2 is an endogenous factor responsible for the IGF-I-induced potentiation of Zn(2+) toxicity and that enhanced COX-2 activity leads to a decrease in the cell"s reducing power and an increase in ROS accumulation in primary cortical cultures.	Zinc	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32
15322227-10	2004	These results suggest that COX-2 is an endogenous factor responsible for the IGF-I-induced potentiation of Zn(2+) toxicity and that enhanced COX-2 activity leads to a decrease in the cell"s reducing power and an increase in ROS accumulation in primary cortical cultures.	Zinc	107-109	insulin like growth factor 1	Homo sapiens	77-82
15256223-3	2004	APC11 contains a RING-H2-finger domain, which includes one histidine and seven cysteine residues that coordinate two Zn(2+) ions.	Zinc	117-119	anaphase promoting complex subunit 11	Homo sapiens	0-5
15159411-1	2004	The subclass B3 FEZ-1 beta-lactamase produced by Fluoribacter (Legionella) gormanii is a Zn(II)-containing enzyme that hydrolyzes the beta-lactam bond in penicillins, cephalosporins, and carbapenems.	Zinc	89-95	fasciculation and elongation protein zeta 1	Homo sapiens	16-21
15260479-3	2004	The NMR structure shows that ND1 of His20 binds to the Zn(2+) atom.	Zinc	55-57	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	29-32
15233916-2	2004	A step in this selective injury is Ca(2+) and/or Zn(2+) entry through Ca(2+)-permeable AMPA receptor channels; reducing Ca(2+) permeability of AMPA receptors via expression of Ca(2+)-impermeable GluR2(R) channels or activation of CRE transcription in the hippocampus of adult rats in vivo using shutoff-deficient pSFV-based vectors rescues vulnerable CA1 pyramidal neurons from forebrain ischemic injury.	Zinc	49-55	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	195-200
15222747-4	2004	Co(2+) was used as a spectroscopic probe in a series of competition titrations to determine the affinity of Co(2+) and Zn(2+) for the C-terminal finger from chicken GATA-1 and the double finger from human GATA-1 (referred to in this report as CF and DF).	Zinc	119-125	GATA binding protein 1	Homo sapiens	205-211
15233916-3	2004	Conversely, the induction of Ca(2+) and/or Zn(2+) influx through AMPA receptors by expressing functional Ca(2+)-permeable GluR2(Q) channels causes the postischemic degeneration of hippocampal granule neurons that otherwise are insensitive to ischemic insult.	Zinc	43-49	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	122-127
15233916-4	2004	Thus, the AMPA receptor subunit GluR2 gates entry of Ca(2+) and/or Zn(2+) that leads to cell death following transient forebrain ischemia.	Zinc	67-69	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	32-37
15252572-8	2004	The electrochemical behaviour of L(1) was studied in the presence of Ni(2+), Cu(2+), Zn(2+), Cd(2+) and Pb(2+), showing that upon complexation the ferrocene-ferrocenium half-wave potential shifts anodically in relation to that of the free ligand.	Zinc	85-87	immunoglobulin kappa variable 1-16	Homo sapiens	33-37
15214085-4	2004	Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations.	Zinc	239-245	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
15187159-9	2004	Zn depletion by chelation, but not by degranulation, also resulted in nuclear translocation of the antiapoptotic, proinflammatory transcription factor NF-kappaB.	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	151-160
15516700-2	2004	Zn has been implicated in diabetes because of its antioxidant properties and interaction with insulin.	Zinc	0-2	insulin	Homo sapiens	94-101
15516700-4	2004	In the present study, it has been observed that both Cr and Zn, upon prolonged exposure, could stimulate tyrosine phosphorylation of insulin receptor (IR) even in the absence of insulin.	Zinc	60-62	insulin	Homo sapiens	133-140
15257610-6	2004	Nevertheless, the metal ion dissociation constants of the Zn- and Cd-mF3 complexes remain similar to those of the native structures at 4.5 x 10(-9) and 3.2 x 10(-8) M, respectively.	Zinc	58-60	coagulation factor III	Mus musculus	69-72
15139010-0	2004	Zn and Cu alteration in connection with astrocyte metallothionein I/II overexpression in the mouse brain upon physical stress.	Zinc	0-2	metallothionein 1	Mus musculus	50-67
15242600-4	2004	However, three loops, involved in DNA and Zn binding in human p53, contain small alpha helices in Cep-1.	Zinc	42-44	tumor protein p53	Homo sapiens	62-65
15242600-4	2004	However, three loops, involved in DNA and Zn binding in human p53, contain small alpha helices in Cep-1.	Zinc	42-44	centriolin	Homo sapiens	98-103
15096503-6	2004	Furthermore, we show that Zn(2+) inhibits Raf-1 binding to ZnT-1.	Zinc	26-28	solute carrier family 30 member 1	Homo sapiens	59-64
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	50-54	solute carrier family 6 member 9 S homeolog	Xenopus laevis	84-90
15255189-1	2004	We investigated the influence of pH and divalent cations (Zn2+, Mg2+ and Ca2+) on high molecular weight kininogen processing by cathepsin B.	Zinc	58-62	kininogen 1	Homo sapiens	82-113
15224132-4	2004	Crystal structure analysis of PDE4"s catalytic domain identifies two metal-binding sites: a high-affinity site and a low-affinity site, which probably bind zinc (Zn2+) and magnesium (Mg2+), respectively.	Zinc	162-166	phosphodiesterase 4A	Homo sapiens	30-34
15469714-8	2004	These results suggest that the modification of Cu,Zn-SOD by oxidized catecholamines might induce the perturbation of cellular antioxidant systems and led to a deleterious cell condition.	Zinc	50-52	superoxide dismutase 1	Homo sapiens	53-56
18969460-1	2004	The zinc cation (Zn(2+)) binding to human serum albumin (HSA) was studied using a non-equilibrium approach in order to prove two HSA binding sites.	Zinc	17-23	albumin	Homo sapiens	42-55
15163458-11	2004	CONCLUSIONS: This study provides evidence that redox-active (Fe2+), (Mn2+), (Cu2+), and (Zn2+) ion-induced apoptosis in PBL by (H2O2)/(.OH) generation, resulting in mitochondria depolarization, caspase-3 activation, and nuclear fragmentation independent of NF-kappaB and p53 transcription factors activation.	Zinc	89-93	caspase 3	Homo sapiens	194-203
15163458-11	2004	CONCLUSIONS: This study provides evidence that redox-active (Fe2+), (Mn2+), (Cu2+), and (Zn2+) ion-induced apoptosis in PBL by (H2O2)/(.OH) generation, resulting in mitochondria depolarization, caspase-3 activation, and nuclear fragmentation independent of NF-kappaB and p53 transcription factors activation.	Zinc	89-93	nuclear factor kappa B subunit 1	Homo sapiens	257-266
15163458-11	2004	CONCLUSIONS: This study provides evidence that redox-active (Fe2+), (Mn2+), (Cu2+), and (Zn2+) ion-induced apoptosis in PBL by (H2O2)/(.OH) generation, resulting in mitochondria depolarization, caspase-3 activation, and nuclear fragmentation independent of NF-kappaB and p53 transcription factors activation.	Zinc	89-93	tumor protein p53	Homo sapiens	271-274
15159208-5	2004	Exposure to Zn or V (6.25-50 microM) for 6 hr produced significant increases in IL-6, IL-1 alpha, heat shock protein 70, and connexin 43 (Cx43).	Zinc	12-14	interleukin 6	Rattus norvegicus	80-84
15159208-5	2004	Exposure to Zn or V (6.25-50 microM) for 6 hr produced significant increases in IL-6, IL-1 alpha, heat shock protein 70, and connexin 43 (Cx43).	Zinc	12-14	interleukin 1 alpha	Rattus norvegicus	86-96
15159208-5	2004	Exposure to Zn or V (6.25-50 microM) for 6 hr produced significant increases in IL-6, IL-1 alpha, heat shock protein 70, and connexin 43 (Cx43).	Zinc	12-14	gap junction protein, alpha 1	Rattus norvegicus	125-136
15159208-5	2004	Exposure to Zn or V (6.25-50 microM) for 6 hr produced significant increases in IL-6, IL-1 alpha, heat shock protein 70, and connexin 43 (Cx43).	Zinc	12-14	gap junction protein, alpha 1	Rattus norvegicus	138-142
15159208-6	2004	After 24 hr exposure, Zn induced significant changes in the gene expression of Kv4.2 and KvLQt (potassium channel proteins), the alpha 1 subunit of the L-type calcium channel, and Cx43, as well as IL-6 and IL-1 alpha.	Zinc	22-24	gap junction protein, alpha 1	Rattus norvegicus	180-184
15159208-6	2004	After 24 hr exposure, Zn induced significant changes in the gene expression of Kv4.2 and KvLQt (potassium channel proteins), the alpha 1 subunit of the L-type calcium channel, and Cx43, as well as IL-6 and IL-1 alpha.	Zinc	22-24	interleukin 6	Rattus norvegicus	197-201
15159208-6	2004	After 24 hr exposure, Zn induced significant changes in the gene expression of Kv4.2 and KvLQt (potassium channel proteins), the alpha 1 subunit of the L-type calcium channel, and Cx43, as well as IL-6 and IL-1 alpha.	Zinc	22-24	interleukin 1 alpha	Rattus norvegicus	206-216
14707133-1	2004	The core protein of glypican-1, a glycosylphosphatidylinositol-linked heparan sulfate proteoglycan, can bind Cu(II) or Zn(II) ions and undergo S-nitrosylation in the presence of nitric oxide.	Zinc	119-125	glypican 1	Rattus norvegicus	20-30
14707133-9	2004	In cell-free experiments, the presence of free Zn(II) ions prevented free Cu(II) ion from binding to glypican-1 and precluded extensive heparan sulfate autodegradation.	Zinc	47-53	glypican 1	Rattus norvegicus	101-111
14707133-10	2004	However, in the presence of Cu(II)-loaded ceruloplasmin, heparan sulfate in Zn(II)-loaded glypican-1 underwent extensive, ascorbate-induced degradation.	Zinc	76-82	glypican 1	Rattus norvegicus	90-100
14707133-11	2004	We propose that the Cu(II)-to-Cu(I)-reduction that is required for S-nitrosylation of glypican-1 can take place on ceruloplasmin and thereby ensure extensive glypican-1 processing in the presence of free Zn(II) ions.	Zinc	204-206	glypican 1	Rattus norvegicus	86-96
15158304-12	2004	The ratio Zn/Cu negatively correlated with triacylglycerol and LDL in all the groups and positively with the ratios Apo AI/Apo B and LDL/Apo B in group A.	Zinc	10-12	apolipoprotein A1	Homo sapiens	116-122
15158304-12	2004	The ratio Zn/Cu negatively correlated with triacylglycerol and LDL in all the groups and positively with the ratios Apo AI/Apo B and LDL/Apo B in group A.	Zinc	10-12	apolipoprotein B	Homo sapiens	123-128
15158304-12	2004	The ratio Zn/Cu negatively correlated with triacylglycerol and LDL in all the groups and positively with the ratios Apo AI/Apo B and LDL/Apo B in group A.	Zinc	10-12	apolipoprotein B	Homo sapiens	137-142
15067523-1	2004	Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media.	Zinc	118-120	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	24-30
15067523-2	2004	In an effort to prepare metal-enriched samples, GLX2-2 was over-expressed in minimal media containing either Zn, Fe, or Mn.	Zinc	109-111	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	48-54
15067523-7	2004	EXAFS spectra on the minimal media GLX2-2 samples over-expressed in the presence of Fe or Zn were also very similar to those of the rich media GLX2-2 samples, indicating the presence of dinuclear metal centers.	Zinc	90-92	Metallo-hydrolase/oxidoreductase superfamily protein	Arabidopsis thaliana	35-41
15173390-1	2004	There is an inverse relation between zinc (Zn) intake and plasma prolactin in men and nonpregnant women.	Zinc	43-45	prolactin	Homo sapiens	65-74
15149199-1	2004	Binding of bis-picolylamine-naphthalene diimide-peptide nucleic acid conjugates to complementary DNA is strongly dependent upon Zn2+; ultimately, hybridization is switched ON in the presence muM Zn2+.	Zinc	128-132	latexin	Homo sapiens	191-194
15149199-1	2004	Binding of bis-picolylamine-naphthalene diimide-peptide nucleic acid conjugates to complementary DNA is strongly dependent upon Zn2+; ultimately, hybridization is switched ON in the presence muM Zn2+.	Zinc	195-199	latexin	Homo sapiens	191-194
15084411-4	2004	A field transplantation experiment, where clams were caged in a gradient relative to an industrial site, demonstrated a positive relationship between MXR levels and (a) metal pollution (Cd and Zn) in the environment and (b) metal bioaccumulation in the gills.	Zinc	193-195	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	150-153
15099744-9	2004	Moreover, the crystal structure of free rat liver BHMT clearly shows that Tyr160 is the fourth ligand coordinated to Zn, which is replaced by Hcy upon binding.	Zinc	117-119	betaine-homocysteine S-methyltransferase	Rattus norvegicus	50-54
15169569-7	2004	Under our experimental conditions, Zn but not Cd, induced SAPK (stress activated protein kinase)/JNK (Jun kinase) activation in cells.	Zinc	35-37	mitogen-activated protein kinase 9	Homo sapiens	58-62
15169569-7	2004	Under our experimental conditions, Zn but not Cd, induced SAPK (stress activated protein kinase)/JNK (Jun kinase) activation in cells.	Zinc	35-37	mitogen-activated protein kinase 9	Homo sapiens	64-95
15169569-7	2004	Under our experimental conditions, Zn but not Cd, induced SAPK (stress activated protein kinase)/JNK (Jun kinase) activation in cells.	Zinc	35-37	mitogen-activated protein kinase 8	Homo sapiens	97-100
15169569-7	2004	Under our experimental conditions, Zn but not Cd, induced SAPK (stress activated protein kinase)/JNK (Jun kinase) activation in cells.	Zinc	35-37	mitogen-activated protein kinase 9	Homo sapiens	102-112
15134918-5	2004	Zn(II) readily displaces Co(II) from IAA as evinced by loss of the Co(II) spectral features.	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
15134918-5	2004	Zn(II) readily displaces Co(II) from IAA as evinced by loss of the Co(II) spectral features.	Zinc	0-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
15134918-6	2004	The dissociation constant for Zn(II), 20 pM at pH 6.5, was determined be competition experiments with Co(II)-IAA.	Zinc	30-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-108
15096035-1	2004	Cu-Zn superoxide dismutase (SOD) contains a conserved, metal-free His residue at an opening of the backbone beta-barrel in addition to six Cu- and/or Zn-bound His residues in the active site.	Zinc	3-5	superoxide dismutase 1	Homo sapiens	28-31
15069187-1	2004	The Cu- and Zn-containing superoxide dismutase 1 (SOD1) largely obtains Cu in vivo by means of the action of the Cu chaperone CCS.	Zinc	12-14	superoxide dismutase 1	Homo sapiens	50-54
15074995-2	2004	The kinetics and thermodynamics of these reactions show that the reactivity of these complexes is affected by metal electronic structure and falls into three groups: Mn(II) and Ni(II) complexes are the most reactive, Fe(II) and Co(II) complexes exhibit intermediate reactivity, and Cu(II) and Zn(II) complexes are the least reactive.	Zinc	293-299	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-234
15046516-9	2004	Molecular mechanics-based docking calculations suggest that one leg of Tatren coordinates to the catalytic Zn(2+) in MMPs-2, -9, and -13 with significant hydrogen bonding to backbone amide groups.	Zinc	107-109	matrix metallopeptidase 13	Homo sapiens	117-121
12972402-2	2004	While studying the effects of zinc ions in normal human bronchial epithelial cell, we uncovered evidence for an additional mechanism of Zn(2+)-induced EGFR activation.	Zinc	136-142	epidermal growth factor receptor	Homo sapiens	151-155
12972402-3	2004	Exposure to Zn(2+) induced phosphorylation of EGFR at tyrosine 1068, a major autophosphorylation site, in a dose- and time-dependent fashion.	Zinc	12-14	epidermal growth factor receptor	Homo sapiens	46-50
12972402-4	2004	This effect of Zn(2+) on EGFR was significantly blocked with an antibody against the ligand-binding domain of the receptor.	Zinc	15-17	epidermal growth factor receptor	Homo sapiens	25-29
12972402-5	2004	Neutralizing antibodies against EGFR ligands revealed the involvement of heparin-binding EGF (HB-EGF) in Zn(2+)-induced EGFR phosphorylation.	Zinc	105-107	epidermal growth factor receptor	Homo sapiens	32-36
12972402-5	2004	Neutralizing antibodies against EGFR ligands revealed the involvement of heparin-binding EGF (HB-EGF) in Zn(2+)-induced EGFR phosphorylation.	Zinc	105-107	epidermal growth factor receptor	Homo sapiens	120-124
12972402-8	2004	Incubation with a specific matrix metalloproteinase-3 inhibitor suppressed Zn(2+)-induced EGFR phosphorylation as well as HB-EGF release.	Zinc	75-81	epidermal growth factor receptor	Homo sapiens	90-94
12972402-9	2004	Therefore, these data support an autocrine or paracrine mechanism whereby Zn(2+) induces EGFR phosphorylation through the extracellular release of EGFR ligands, which may be mediated by metalloproteinases.	Zinc	74-80	epidermal growth factor receptor	Homo sapiens	89-93
12972402-9	2004	Therefore, these data support an autocrine or paracrine mechanism whereby Zn(2+) induces EGFR phosphorylation through the extracellular release of EGFR ligands, which may be mediated by metalloproteinases.	Zinc	74-80	epidermal growth factor receptor	Homo sapiens	147-151
15041663-6	2004	Analyses with Co2+ and Mn2+, together with previous results, indicate that for the first-row transition metals the rank order for the inhibition of Kv1.5 in 0 mM Ko+ is Zn2+ (KD approximately 0.07 mM) &gt; or = Ni2+) (KD approximately 0.15 mM) &gt; Co2+ (KD approximately 1.4 mM) &gt; Mn2+ (KD &gt; 10 mM).	Zinc	169-173	potassium voltage-gated channel subfamily A member 5	Homo sapiens	148-153
14999810-5	2004	Zn(2+)-induced cell death in astrocytes was at least in part apoptotic, as caspase-3 was activated, and the caspase inhibitor Z-Val-Ala-Asp-fluoromethylketone partially attenuated Zn(2+)-induced death.	Zinc	0-2	caspase 3	Homo sapiens	75-84
15041244-1	2004	Zn(2+) and Cd(2+) ion exchange between transcription factor IIIA (TFIIIA) and apo-metallothionein (MT) were studied using a combination of methods including chromatography, ultrafiltration and UV spectroscopy.	Zinc	0-2	general transcription factor IIIA	Homo sapiens	39-64
15041244-1	2004	Zn(2+) and Cd(2+) ion exchange between transcription factor IIIA (TFIIIA) and apo-metallothionein (MT) were studied using a combination of methods including chromatography, ultrafiltration and UV spectroscopy.	Zinc	0-2	general transcription factor IIIA	Homo sapiens	66-72
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	163-167	solute carrier family 6 member 9 S homeolog	Xenopus laevis	84-90
15031290-6	2004	Using site-directed mutagenesis, we identified 2 histidine residues, His-243 in the large second extracellular loop (ECL2) and His-410 in the fourth extracellular loop (ECL4), as two coordinates in the Zn2+ binding site of GLYT1b.	Zinc	202-206	solute carrier family 6 member 9 S homeolog	Xenopus laevis	223-229
15031290-8	2004	The ability of Zn2+ and protons to regulate the rate of glycine transport by interacting with residues situated in ECL4 of GLYT1b suggests that this region may influence the substrate translocation mechanism.	Zinc	15-19	solute carrier family 6 member 9 S homeolog	Xenopus laevis	123-129
12639846-9	2004	LPS+thymulin+Zn(2+)-treated explants showed proliferation of CCAAT-enhancer binding protein-beta (C/EBPbeta) and fibroblast growth factor-9 immunoreactive mesenchyme, which was abolished by IL-6 antisense oligonucleotides.	Zinc	13-15	interleukin 6	Rattus norvegicus	190-194
15039103-6	2004	These findings suggest that GIF may inhibit Zn(2+)-induced neuronal death via its interaction with Rab3A.	Zinc	44-50	RAB3A, member RAS oncogene family	Rattus norvegicus	99-104
14977522-8	2004	Exposure of ARPE-19 cells to Zn2+ led to the activation of ERK1/2, JNK1/2/3, and p38 MAPKs.	Zinc	29-33	mitogen-activated protein kinase 3	Homo sapiens	59-65
15014132-12	2004	Moreover, Zn(2+) and SKF96365 both blocked the excitatory effect of NT, suggesting that nonselective cationic conductances are involved.	Zinc	10-16	neurotensin	Homo sapiens	68-70
14641108-0	2004	Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB.	Zinc	8-12	general transcription factor IIB	Homo sapiens	64-98
14641108-5	2004	The NMR data show that, whereas the backbone fold of NTD is pre-formed in the apo state, Zn2 binding reduces backbone mobility in the b-turn (Arg28-Gly30), induces enhanced structural rigidity of the charged-cluster domain in the central linker region of TFIIB and appends a positive surface charge within the Zn2-binding site.	Zinc	89-92	general transcription factor IIB	Homo sapiens	255-260
14641108-7	2004	These structural effects of Zn2 binding on TFIIB may have a critical role in interactions with its binding partners, such as the Rpb1 subunit of RNA polymerase II.	Zinc	28-31	general transcription factor IIB	Homo sapiens	43-48
14977522-8	2004	Exposure of ARPE-19 cells to Zn2+ led to the activation of ERK1/2, JNK1/2/3, and p38 MAPKs.	Zinc	29-33	mitogen-activated protein kinase 8	Homo sapiens	67-75
14977522-8	2004	Exposure of ARPE-19 cells to Zn2+ led to the activation of ERK1/2, JNK1/2/3, and p38 MAPKs.	Zinc	29-33	mitogen-activated protein kinase 1	Homo sapiens	81-84
15129976-6	2004	(3) The size of insulin particles showed the following order: human insulin &gt; lyophilized human insulin &gt; Zn-free human insulin.	Zinc	112-114	insulin	Homo sapiens	16-23
15129976-7	2004	Zn-free insulin was similar to lyophilized insulin with respect to control of rapid release, so a smaller particle size was essential.	Zinc	0-2	insulin	Homo sapiens	8-15
14741272-1	2004	We have demonstrated that thiol-bearing analogues of alpha-chymotrysin (alpha-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits alpha-CT, a prototypical serine protease, in the presence of Zn(II) ion.	Zinc	231-233	coagulation factor II, thrombin	Homo sapiens	195-210
15076160-9	2004	The activity of Cu/Zn-SOD in the thoracic aorta was significantly reduced in rats fed a high Zn diet relative to rats fed a standard diet, appearing to at least in part, play a role in an increase in the action of superoxide in the vessel wall of rats fed a high Zn diet.	Zinc	93-95	superoxide dismutase 1	Rattus norvegicus	16-25
14766175-4	2004	Free Zn2+ in turn induces respiratory block, mitochondrial permeability transition (mPT), cytochrome c release, generation of reactive oxygen species (ROS), and p38 MAP kinase activation.	Zinc	5-9	cytochrome c, somatic	Homo sapiens	90-102
14766175-4	2004	Free Zn2+ in turn induces respiratory block, mitochondrial permeability transition (mPT), cytochrome c release, generation of reactive oxygen species (ROS), and p38 MAP kinase activation.	Zinc	5-9	mitogen-activated protein kinase 14	Homo sapiens	161-164
14970904-0	2004	Effect of Zn(II) on the structure and biological activity of natural beta-NGF.	Zinc	10-16	nerve growth factor	Homo sapiens	69-77
14970904-2	2004	Flameless atomic absorption spectroscopy (FAAS) measurements reveal that native beta-NGF contains Zn(II) with a Zn(II)/beta-NGF stoichiometry of 1:14.6.	Zinc	98-104	nerve growth factor	Homo sapiens	80-88
14970904-2	2004	Flameless atomic absorption spectroscopy (FAAS) measurements reveal that native beta-NGF contains Zn(II) with a Zn(II)/beta-NGF stoichiometry of 1:14.6.	Zinc	112-118	nerve growth factor	Homo sapiens	80-88
14970904-3	2004	The presence of Zn(II) in the native molecule results in significant changes of the secondary structure and local tertiary structure around Trp(s) with respect to those of apo beta-NGF, as suggested by spectra of fluorescence and circular dichrosim.	Zinc	16-22	nerve growth factor	Homo sapiens	176-184
14970904-6	2004	Thus it is most likely that the structural changes caused by the presence of Zn(II) directly lead to the increase in the biological activity of beta-NGF.	Zinc	77-83	nerve growth factor	Homo sapiens	144-152
14970904-7	2004	All results indicate that Zn(II) in native beta-NGF plays an important role in the structure and the biological activity of the protein.	Zinc	26-32	nerve growth factor	Homo sapiens	43-51
14693136-3	2004	As for lead(II) (Pb(II)), experimental data and modeling results indicate that a multistage sorption system can significantly reduce Zn(II) effluent concentrations for the same total amount of sorbent or, alternatively, dramatically lower total sorbent consumption for the same effluent Zn(II) concentration.	Zinc	133-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	7-23
14685271-0	2004	Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.	Zinc	56-58	kinase suppressor of ras 1	Homo sapiens	14-17
14765975-1	2004	Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands.	Zinc	6-12	insulin-like growth factor binding protein 5	Mus musculus	171-178
14765975-1	2004	Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands.	Zinc	6-12	insulin-like growth factor I receptor	Mus musculus	276-283
14765975-3	2004	In the current work, we demonstrate that Zn(2+) affects the affinity of IGFBP-5 secreted by myoblasts but not IGFBP-4.	Zinc	41-43	insulin-like growth factor binding protein 5	Mus musculus	72-79
14765975-6	2004	Zn(2+) converted the high affinity binding sites of IGFBP-5 into low affinity binding sites.	Zinc	0-2	insulin-like growth factor binding protein 5	Mus musculus	52-59
14685271-6	2004	Instead, Zn(2+) ions target a specific step of the pathway, probably regulation of the scaffolding protein KSR.	Zinc	9-15	kinase suppressor of ras 1	Homo sapiens	107-110
14685271-7	2004	Biochemical analysis in mammalian cells indicates that high Zn(2+) concentration causes a dramatic increase of KSR phosphorylation.	Zinc	60-66	kinase suppressor of ras 1	Homo sapiens	111-114
14695264-2	2004	When coinjected with KAT1 in Xenopus oocytes, KDC1 participates in the formation of heteromultimeric KDC1:KAT1 channels and the ionic current is potentiated by extracellular Zn2+.	Zinc	174-178	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	21-25
15070437-7	2004	Human intestinal Caco-2 cells show a similar response to increasing the Zn2+ concentration of the nutrient medium in relation to the expression of mRNA corresponding to several Zn transporters and that of ZnT1 (SLC30A1) and hZTL1/ZnT5 proteins.	Zinc	72-76	solute carrier family 30 member 1	Homo sapiens	205-209
15070437-7	2004	Human intestinal Caco-2 cells show a similar response to increasing the Zn2+ concentration of the nutrient medium in relation to the expression of mRNA corresponding to several Zn transporters and that of ZnT1 (SLC30A1) and hZTL1/ZnT5 proteins.	Zinc	72-76	solute carrier family 30 member 1	Homo sapiens	211-218
14695264-2	2004	When coinjected with KAT1 in Xenopus oocytes, KDC1 participates in the formation of heteromultimeric KDC1:KAT1 channels and the ionic current is potentiated by extracellular Zn2+.	Zinc	174-178	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	106-110
15508121-1	2004	The solution NMR conformational properties of two angiotensin converting enzyme (ACE) Zn catalytic-site 36-residue peptides, with the general sequence HEMGHX23EAIGDX3, synthesized through solid-phase 9-fluorenylmethoxycarbonyl (Fmoc) chemistry, is reported.	Zinc	86-88	angiotensin I converting enzyme	Homo sapiens	50-79
15508121-1	2004	The solution NMR conformational properties of two angiotensin converting enzyme (ACE) Zn catalytic-site 36-residue peptides, with the general sequence HEMGHX23EAIGDX3, synthesized through solid-phase 9-fluorenylmethoxycarbonyl (Fmoc) chemistry, is reported.	Zinc	86-88	angiotensin I converting enzyme	Homo sapiens	81-84
15509014-5	2004	Two-step extraction, using 10mM CuSO4 solution for exchangeable sorbed ions and 10-20mM hydroxylamine hydrochloride for ions bound to reducible Mn oxide phase, showed higher irreversibility of Co(II) and Ni(II) sorption on the biogenic Mn oxides while Zn(II) sorption was mostly reversible (Cu(II)-exchangeable).	Zinc	252-258	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-199
15508121-2	2004	The 1H resonance assignment of Zn-bound peptides is presented and the characteristic features of the NMR solution models of the two ACE Zn(II)-bound peptides are reported.	Zinc	136-142	angiotensin I converting enzyme	Homo sapiens	132-135
14703604-9	2003	Investigating the footballers" data with Spearman"s correlation analyses, the correlation coefficients (r) between Zn/Cu ratio and SOD was positive (r=0.44; p &lt; 0.05); and between VO2max and SOD (r=0.42; p &lt; 0.05) were both positive.	Zinc	115-117	superoxide dismutase 1	Homo sapiens	131-134
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	ZIP metal ion transporter family	Arabidopsis thaliana	102-108
14622981-6	2003	In the presence of AA, 50 microM Zn enhanced mRNA expression of the osteoblastic differentiation markers alkaline phosphatase, alpha(1)(I) procollagen, osteopontin (OPN), and osteocalcin (OCN) by 3.9-, 3.8-, 3.3-, and 3.5-fold, respectively; in the absence of AA, the Zn-induced increase was 2.8-, 2.5-, 1.3-, and 1.1-fold, respectively.	Zinc	33-35	bone gamma-carboxyglutamate protein	Homo sapiens	175-186
14622981-6	2003	In the presence of AA, 50 microM Zn enhanced mRNA expression of the osteoblastic differentiation markers alkaline phosphatase, alpha(1)(I) procollagen, osteopontin (OPN), and osteocalcin (OCN) by 3.9-, 3.8-, 3.3-, and 3.5-fold, respectively; in the absence of AA, the Zn-induced increase was 2.8-, 2.5-, 1.3-, and 1.1-fold, respectively.	Zinc	33-35	bone gamma-carboxyglutamate protein	Homo sapiens	188-191
14622981-7	2003	These findings suggest that AA and SVCT2 mediate Zn-induced OPN and OCN expression and partly regulate Zn-induced osteoblastic differentiation.	Zinc	49-51	bone gamma-carboxyglutamate protein	Homo sapiens	68-71
14566968-2	2003	The list of functions for this micronutrient expanded with the recent discovery that Zn(2+) retains insulin-like growth factors binding proteins (IGFBPs) on the surface of cultured cells, lowers the affinity of cell-associated IGFBPs, and increases the affinity of the cell surface insulin-like growth factor (IGF)-type 1 receptor (IGF-1R).	Zinc	85-91	insulin-like growth factor binding protein 5	Mus musculus	146-152
14665725-3	2003	Zinc (Zn), a trace element with important biological functions, is located in the catalytic site of ACE.	Zinc	6-8	angiotensin I converting enzyme	Homo sapiens	100-103
14684753-2	2003	The most important degradative system is insulin degrading enzyme which is a highly conserved metalloendopeptidase requiring Zn(++) for its proteolytic action, although protein disulfide isomerase and cathepsin D are also involved in insulin metabolism.	Zinc	125-131	insulin	Homo sapiens	41-48
14566968-2	2003	The list of functions for this micronutrient expanded with the recent discovery that Zn(2+) retains insulin-like growth factors binding proteins (IGFBPs) on the surface of cultured cells, lowers the affinity of cell-associated IGFBPs, and increases the affinity of the cell surface insulin-like growth factor (IGF)-type 1 receptor (IGF-1R).	Zinc	85-91	insulin-like growth factor binding protein 5	Mus musculus	227-233
14566968-2	2003	The list of functions for this micronutrient expanded with the recent discovery that Zn(2+) retains insulin-like growth factors binding proteins (IGFBPs) on the surface of cultured cells, lowers the affinity of cell-associated IGFBPs, and increases the affinity of the cell surface insulin-like growth factor (IGF)-type 1 receptor (IGF-1R).	Zinc	85-91	insulin-like growth factor I receptor	Mus musculus	332-338
14566968-6	2003	Zn(2+) acts by lowering the affinity (K(a)) of IGFBP-5 for the IGFs.	Zinc	0-2	insulin-like growth factor binding protein 5	Mus musculus	47-54
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor I receptor	Mus musculus	110-116
14566968-10	2003	Zn(2+) was active at physiological doses depressing IGF binding to IGFBP-5 and the IGF-2R at 15-20 microM.	Zinc	0-2	insulin-like growth factor binding protein 5	Mus musculus	67-74
14617770-0	2003	Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release.	Zinc	123-127	nitric oxide synthase 2, inducible	Mus musculus	34-55
14690761-10	2003	In liver, metallothionein subtype 1 and 2 (MT-1 and MT-2) genes could be shown to be dramatically repressed and therefore represent putative markers for Zn deficiency.	Zinc	153-155	metallothionein 1	Rattus norvegicus	43-56
14621986-6	2003	Thus, chemical shift perturbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could be detecting structural changes in the Ca(2+)-binding domains of S100B that are pertinent to its increase in Ca(2+)-binding affinity in the presence of Zn(2+).	Zinc	102-104	S100 calcium binding protein B	Homo sapiens	89-94
14617770-3	2003	We show here that, in cytokine-activated murine aortic endothelial cells, NO derived from the inducible NO synthase (iNOS) induces a transient nuclear release of Zn2+.	Zinc	162-166	nitric oxide synthase 2, inducible	Mus musculus	94-115
14621986-6	2003	Thus, chemical shift perturbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could be detecting structural changes in the Ca(2+)-binding domains of S100B that are pertinent to its increase in Ca(2+)-binding affinity in the presence of Zn(2+).	Zinc	102-104	S100 calcium binding protein B	Homo sapiens	191-196
14621986-8	2003	This change in secondary structure likely contributes to the increased binding affinity that S100B has for target peptides (i.e., TRTK peptide) in the presence of Zn(2+).	Zinc	163-165	S100 calcium binding protein B	Homo sapiens	93-98
14624585-4	2003	(1) In the present work, 5 mM solutions of commercial human Hb were found by ICP-MS to contain approximately 20 microM Cu and Zn, suggesting the presence of Cu,Zn-superoxide dismutase (CuZnSOD), which was confirmed by Western blotting.	Zinc	126-128	superoxide dismutase 1	Homo sapiens	157-183
14617770-3	2003	We show here that, in cytokine-activated murine aortic endothelial cells, NO derived from the inducible NO synthase (iNOS) induces a transient nuclear release of Zn2+.	Zinc	162-166	nitric oxide synthase 2, inducible	Mus musculus	117-121
14617770-6	2003	In addition, we found that, endogenously via iNOS, synthesized NO increases the constitutive mRNA expression of both MT-1 and MT-2 genes and that nitrosative stress exogenously applied via an NO donor increases constitutive MT mRNA expression via intracellular Zn2+ release.	Zinc	261-265	nitric oxide synthase 2	Homo sapiens	45-49
14617770-7	2003	In conclusion, we here provide evidence for a signaling mechanism based on iNOS-derived NO through the regulation of intracellular Zn2+ trafficking and homeostasis.	Zinc	131-135	nitric oxide synthase 2, inducible	Mus musculus	75-79
14621986-0	2003	Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis.	Zinc	16-22	S100 calcium binding protein B	Homo sapiens	39-44
14621986-1	2003	In addition to binding Ca(2+), the S100 protein S100B binds Zn(2+) with relatively high affinity as confirmed using isothermal titration calorimetry (ITC; K(d) = 94 +/- 17 nM).	Zinc	60-62	S100 calcium binding protein B	Homo sapiens	35-39
14621986-1	2003	In addition to binding Ca(2+), the S100 protein S100B binds Zn(2+) with relatively high affinity as confirmed using isothermal titration calorimetry (ITC; K(d) = 94 +/- 17 nM).	Zinc	60-62	S100 calcium binding protein B	Homo sapiens	48-53
14621986-2	2003	The Zn(2+)-binding site on Ca(2+)-bound S100B was examined further using NMR spectroscopy and site-directed mutagenesis.	Zinc	4-10	S100 calcium binding protein B	Homo sapiens	40-45
14621986-3	2003	Specifically, ITC measurements of S100B mutants (helix 1, H15A and H25A; helix 4, C84A, H85A, and H90A) were found to bind Zn(2+) with lower affinity than wild-type S100B (from 2- to &gt;25-fold).	Zinc	123-125	S100 calcium binding protein B	Homo sapiens	34-39
14621986-4	2003	Thus, His-15, His-25, Cys-84, His-85, and perhaps His-90 of S100B are involved in coordinating Zn(2+), which was confirmed by NMR spectroscopy.	Zinc	95-97	S100 calcium binding protein B	Homo sapiens	60-65
14621986-6	2003	Thus, chemical shift perturbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could be detecting structural changes in the Ca(2+)-binding domains of S100B that are pertinent to its increase in Ca(2+)-binding affinity in the presence of Zn(2+).	Zinc	102-108	S100 calcium binding protein B	Homo sapiens	89-94
14621986-6	2003	Thus, chemical shift perturbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could be detecting structural changes in the Ca(2+)-binding domains of S100B that are pertinent to its increase in Ca(2+)-binding affinity in the presence of Zn(2+).	Zinc	102-108	S100 calcium binding protein B	Homo sapiens	191-196
14622293-8	2003	Atomic force microscopy studies showed that Abeta aged at pH 5.0 or in the presence of Zn2+ produced larger looser rod-shaped aggregates than at pH 7.4.	Zinc	87-91	amyloid beta precursor protein	Homo sapiens	44-49
12904958-2	2003	The cellulose with DHP anchored by the shorter linker had better sorption capacity (between 69.7 and 431.1 micromol g(-1)) for Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Pb(II), and Fe(III)) than the other (51.9-378.1 micromol g(-1)); the former was therefore studied in detail as a solid extractant for these metal ions.	Zinc	151-157	dihydropyrimidinase	Homo sapiens	19-22
14552064-3	2003	alpha-Lactalbumin binds divalent cations (Ca, Zn) and may facilitate the absorption of essential minerals, and it provides a well-balanced supply of essential amino acids to the growing infant.	Zinc	46-48	lactalbumin alpha	Homo sapiens	0-17
14500983-3	2003	We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes.	Zinc	67-71	CD4 molecule	Homo sapiens	59-62
14617798-9	2003	It was further observed that the GIP can bind both Zn(2+) and Co(2+); the Co(2+) peptide complex was shown to have a distorted tetrahedral symmetry, involving coordination of two cysteine and two histidine residues.	Zinc	51-57	gastric inhibitory polypeptide	Homo sapiens	33-36
12974631-6	2003	Bound Zn(2+) has previously been shown to be required for the catalytic activity of hAGT (Rasimas, J. J. et al.	Zinc	6-8	angiotensinogen	Homo sapiens	84-88
12906931-14	2003	Results are discussed in relation to Zn(2+)-interactive inhibition of insulin degradation in hormone target tissues, and Fe(3+)-interactive inhibition of hemoglobin degradation in parasite food vacuoles.	Zinc	37-43	insulin	Homo sapiens	70-77
12924942-2	2003	The Zn(2+)-binding cysteine/histidine-rich 1 (CH1) domain of p300/CBP binds many of these transcription factors, including hypoxia-inducible factor (HIF).	Zinc	4-10	CREB binding protein	Homo sapiens	66-69
12915106-0	2003	Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.	Zinc	14-20	epidermal growth factor receptor	Homo sapiens	59-91
12915106-3	2003	In the present study, we studied the mechanisms of epidermal growth factor receptor (EGFR) dimerization, phosphorylation, and kinase activity in A431 cells treated with Zn(2+).	Zinc	169-171	epidermal growth factor receptor	Homo sapiens	51-83
12915106-3	2003	In the present study, we studied the mechanisms of epidermal growth factor receptor (EGFR) dimerization, phosphorylation, and kinase activity in A431 cells treated with Zn(2+).	Zinc	169-171	epidermal growth factor receptor	Homo sapiens	85-89
12915106-5	2003	Like EGF, Zn(2+) induced phosphorylation of EGFR at tyrosines 845, 1068, and 1173.	Zinc	10-12	epidermal growth factor receptor	Homo sapiens	44-48
12915106-9	2003	Inhibition of EGFR kinase activity did, however, blunt Zn(2+)-induced phosphorylation of ERK.	Zinc	55-61	epidermal growth factor receptor	Homo sapiens	14-18
12915106-9	2003	Inhibition of EGFR kinase activity did, however, blunt Zn(2+)-induced phosphorylation of ERK.	Zinc	55-61	mitogen-activated protein kinase 1	Homo sapiens	89-92
12915106-10	2003	Exposure to Zn(2+), but not EGF, induced phosphorylation of the activating site of c-Src (tyrosine 416), and Zn(2+)-induced phosphorylation of EGFR at tyrosines 845 and 1068 was blocked by the c-Src kinase activity inhibitor PP2.	Zinc	12-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-88
12915106-10	2003	Exposure to Zn(2+), but not EGF, induced phosphorylation of the activating site of c-Src (tyrosine 416), and Zn(2+)-induced phosphorylation of EGFR at tyrosines 845 and 1068 was blocked by the c-Src kinase activity inhibitor PP2.	Zinc	109-111	epidermal growth factor receptor	Homo sapiens	143-147
12915106-11	2003	In summary, Zn(2+) ions induce EGFR phosphorylation in a manner dependent on c-Src but not on EGFR dimerization or EGFR kinase activation, suggesting that Zn(2+) induces EGFR transactivation by c-Src.	Zinc	12-14	epidermal growth factor receptor	Homo sapiens	31-35
12915106-11	2003	In summary, Zn(2+) ions induce EGFR phosphorylation in a manner dependent on c-Src but not on EGFR dimerization or EGFR kinase activation, suggesting that Zn(2+) induces EGFR transactivation by c-Src.	Zinc	12-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	77-82
12915106-11	2003	In summary, Zn(2+) ions induce EGFR phosphorylation in a manner dependent on c-Src but not on EGFR dimerization or EGFR kinase activation, suggesting that Zn(2+) induces EGFR transactivation by c-Src.	Zinc	12-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	194-199
12915106-11	2003	In summary, Zn(2+) ions induce EGFR phosphorylation in a manner dependent on c-Src but not on EGFR dimerization or EGFR kinase activation, suggesting that Zn(2+) induces EGFR transactivation by c-Src.	Zinc	155-157	epidermal growth factor receptor	Homo sapiens	31-35
14515014-5	2003	Zn2+, Cd2+, and Au3+, but not La3+, decreased total binding and the affinity for [125I]IGF-II association with IGFBP-3 and IGFBP-5.	Zinc	0-4	insulin like growth factor binding protein 5	Homo sapiens	123-130
12907654-2	2003	LNCaP-derived C4-2 human prostate cancer cells are quite resistant to treatment with Apo2 ligand (Apo2L) or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), when using a nontagged, Zn-bound recombinant trimeric version that is devoid of any exogeneous sequences and therefore least likely to be immunogenic in human patients and that has been optimized for maximum efficacy and minimum toxicity.	Zinc	197-199	TNF superfamily member 10	Homo sapiens	108-163
14515014-9	2003	Together with the current work, these findings imply that Zn2+ acts in vivo to prevent secreted IGF-II from binding to IGFBP-3 and IGFBP- 5, thus maintaining IGF-II in an "active state," i.e., readily available for IGF-1R association.	Zinc	58-62	insulin like growth factor binding protein 5	Homo sapiens	131-139
12839865-14	2003	Thus, Zn(2+) acts as a bidirectional modulator of ATP receptor channels in tuberomamillary neurons, which possess functional P2X(2) receptors.	Zinc	6-12	purinergic receptor P2X 7	Rattus norvegicus	50-62
12743124-2	2003	Exposure to Zn2+ ions induces Akt activation, suggesting that PTEN may be modulated in this process.	Zinc	12-16	AKT serine/threonine kinase 1	Homo sapiens	30-33
12743124-7	2003	PTEN phosphatase activity evaluated by measuring Akt phosphorylation decreased after Zn2+ treatment.	Zinc	85-89	AKT serine/threonine kinase 1	Homo sapiens	49-52
12907825-9	2003	In infants, there is a significant positive correlation between serum Zn and cholesterol, LDL-C, and Apo B.	Zinc	70-72	apolipoprotein B	Homo sapiens	101-106
12778114-4	2003	The high-resolution solution structure of the CITED2 TAD-p300 CH1 complex shows that the CITED2 TAD, like the HIF-1alpha C-TAD, folds on a helical, Zn2+-containing CH1 scaffold.	Zinc	148-152	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	46-52
12792793-13	2003	If white patients were stratified according to the type and location of TP53 mutations, patients with mutations affecting amino acids directly involved in DNA or Zn binding displayed a poor prognosis.	Zinc	162-164	tumor protein p53	Homo sapiens	72-76
12778114-4	2003	The high-resolution solution structure of the CITED2 TAD-p300 CH1 complex shows that the CITED2 TAD, like the HIF-1alpha C-TAD, folds on a helical, Zn2+-containing CH1 scaffold.	Zinc	148-152	zinc finger TRAF-type containing 1	Homo sapiens	62-65
12778114-4	2003	The high-resolution solution structure of the CITED2 TAD-p300 CH1 complex shows that the CITED2 TAD, like the HIF-1alpha C-TAD, folds on a helical, Zn2+-containing CH1 scaffold.	Zinc	148-152	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	89-95
12778114-4	2003	The high-resolution solution structure of the CITED2 TAD-p300 CH1 complex shows that the CITED2 TAD, like the HIF-1alpha C-TAD, folds on a helical, Zn2+-containing CH1 scaffold.	Zinc	148-152	zinc finger TRAF-type containing 1	Homo sapiens	164-167
14563015-11	2003	Hypothetically, low, intestinal Zn2+ -levels facilitate Ca2+-activation of tTg, which deamidates gliadin.	Zinc	32-36	transglutaminase 2	Homo sapiens	75-78
12729761-2	2003	Zn-deficient wild-type and mutant human SOD1 have been implicated in the disease familial amyotrophic lateral sclerosis (FALS).	Zinc	0-2	superoxide dismutase 1	Homo sapiens	40-44
12582160-0	2003	Decorin binds fibrinogen in a Zn2+-dependent interaction.	Zinc	30-34	fibrinogen beta chain	Homo sapiens	14-24
12729211-3	2003	This work examines the theoretical and experimental basis for the use of BCF/BAF in the hazard assessment of Zn, Cd, Cu, Pb, Ni, and Ag.	Zinc	109-111	BAF nuclear assembly factor 1	Homo sapiens	77-80
12729211-5	2003	The BCF/BAF data for Zn, Cd, Cu, Pb, Ni, and Ag were characterized by extreme variability in mean BCF/BAF values and a clear inverse relationship between BCF/BAF and aqueous exposure.	Zinc	21-23	BAF nuclear assembly factor 1	Homo sapiens	8-11
12729211-5	2003	The BCF/BAF data for Zn, Cd, Cu, Pb, Ni, and Ag were characterized by extreme variability in mean BCF/BAF values and a clear inverse relationship between BCF/BAF and aqueous exposure.	Zinc	21-23	BAF nuclear assembly factor 1	Homo sapiens	102-105
12729211-5	2003	The BCF/BAF data for Zn, Cd, Cu, Pb, Ni, and Ag were characterized by extreme variability in mean BCF/BAF values and a clear inverse relationship between BCF/BAF and aqueous exposure.	Zinc	21-23	BAF nuclear assembly factor 1	Homo sapiens	102-105
12582160-4	2003	We now report that the decorin proteoglycan binds fibrinogen in the presence of Zn(2+).	Zinc	80-82	fibrinogen beta chain	Homo sapiens	50-60
12646273-4	2003	Purified recombinant TTP bound to the AU-rich element of tumor necrosis factor-alpha (TNFalpha) mRNA and this binding was dependent on Zn(2+).	Zinc	135-137	tumor necrosis factor	Homo sapiens	57-84
12645003-10	2003	Further specificity in S100-target protein interactions may arise from the different biochemical/biophysical properties of the individual family members, including affinity for metal ions (Ca(2+), Zn(2+), and Cu(2+)), oligomerization properties, heterodimerization, post-translational modifications, and lipid-binding.	Zinc	197-199	S100 calcium binding protein A1	Homo sapiens	23-27
12646273-4	2003	Purified recombinant TTP bound to the AU-rich element of tumor necrosis factor-alpha (TNFalpha) mRNA and this binding was dependent on Zn(2+).	Zinc	135-137	tumor necrosis factor	Homo sapiens	86-94
12616534-7	2003	The loss of intracellular Zn(2+) was accompanied by a significant reduction in the cytosolic metal-binding protein metallothionein.	Zinc	26-28	metallothionein 4	Gallus gallus	115-130
12684815-0	2003	Metallothionein-1 and metallothionein-2 gene expression and localisation of apoptotic cells in Zn-treated LEC rat liver.	Zinc	95-97	metallothionein 1	Rattus norvegicus	0-17
12686631-9	2003	Ehp53 also contains seven of the eight DNA-binding residues and two of the four Zn(2+)-binding sites described for p53.	Zinc	80-86	tumor protein p53	Homo sapiens	2-5
14498762-11	2003	In solution, the aggregation of human prolactin at mildly acidic pH and physiological concentrations of Zn(2+) resembles that which occurs in cells if the reaction is performed with macromolecular crowding, which will mimic the conditions in cells.	Zinc	104-106	prolactin	Homo sapiens	38-47
12640458-6	2003	We found that the characteristically low Zn2+ sensitivity of GABA(A) receptors containing the gamma2 subunit results from disruption to two of the three sites after receptor subunit co-assembly.	Zinc	41-45	tryptophanyl-tRNA synthetase 1	Homo sapiens	94-100
12646702-0	2003	The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c.	Zinc	121-123	cytochrome c, somatic	Homo sapiens	124-136
12646702-1	2003	The kinetics of electron transfer from the triplet-excited Zn-porphyrin to a Ru(NH(3))(5)(His-33)(3+) complex have been measured in Zn-substituted ruthenium-modified cytochrome c under denaturing conditions.	Zinc	59-61	cytochrome c, somatic	Homo sapiens	166-178
12703789-1	2003	The CoI2(PPh3)2/Zn system effectively catalyzes the [2 + 2 + 2] ene-diyne cycloaddition of 1,6-heptadiynes with allenes in a highly regio- and chemoselective fashion to yield substituted benzene derivatives in good to excellent yields.	Zinc	16-18	caveolin 1	Homo sapiens	9-13
12435742-3	2003	In the presence of Zn(2+), A beta 40 and A beta 42 both inserted into the bilayer over the pH range 5.5-7.5, as did A beta 42 in the presence of Cu(2+).	Zinc	19-21	amyloid beta precursor protein	Homo sapiens	27-33
12600206-11	2003	Through a combination of induced p53 aggregation and diminished site-specific DNA binding activity, Zn(2+) loss may represent a significant inactivation pathway for p53 in the cell.	Zinc	100-106	tumor protein p53	Homo sapiens	33-36
12600206-11	2003	Through a combination of induced p53 aggregation and diminished site-specific DNA binding activity, Zn(2+) loss may represent a significant inactivation pathway for p53 in the cell.	Zinc	100-106	tumor protein p53	Homo sapiens	165-168
12441345-0	2003	Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation.	Zinc	0-6	dimethylarginine dimethylaminohydrolase 1	Bos taurus	12-32
12441345-0	2003	Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation.	Zinc	0-6	dimethylarginine dimethylaminohydrolase 1	Bos taurus	34-40
12441345-2	2003	Dimethylargininase-1 from bovine brain contains one tightly bound Zn(II) coordinated by two cysteine sulfur and two lighter ligands.	Zinc	66-72	dimethylarginine dimethylaminohydrolase 1	Bos taurus	0-20
18365046-0	2003	Interaction of Cu(II)with His-Val-Gly-Asp and of Zn(II) with His-Val-His, two peptides at the active site of Cu,Zn-superoxide dismutase.	Zinc	49-51	superoxide dismutase 1	Homo sapiens	109-135
12542292-4	2003	The order of the lability of the metal complexes, Co(II) &gt; Ni(II) &gt; Cu(II) &lt; Zn(II), follows the reverse order of the ligand field stabilization energy with the exception of Cu(II); the behavior of Cu(II) is also due to the Jahn-Teller effect, which shortens the equatorial bonds and lengthens the axial bonds of a tetragonally distorted Cu(II)-L6 complex.	Zinc	86-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
14716091-5	2003	Overloading Zn(II) is initially mainly bound to human serum albumin (HSA).	Zinc	12-18	albumin	Homo sapiens	54-67
12361735-5	2002	One of these studies is time-dependent changes of the MT-1/MT-2 ratio in the cytosol of the pancreas and liver in mice after Zn or Cd injection.	Zinc	125-127	metallothionein 1	Mus musculus	54-63
14650623-6	2003	Zn also induced CD4+ lymphocyte proliferation, but it abolished or reduced most Ni-mediated effects.	Zinc	0-2	CD4 molecule	Homo sapiens	16-19
12377780-1	2002	The Zn(2+)- and Ca(2+)-binding S100B protein is implicated in multiple intracellular and extracellular regulatory events.	Zinc	4-10	S100 calcium binding protein B	Homo sapiens	31-36
12377780-3	2002	We have identified the IQGAP1 protein as the major cytoplasmic S100B target protein in different rat and human glial cell lines in the presence of Zn(2+) and Ca(2+).	Zinc	147-149	IQ motif containing GTPase activating protein 1	Rattus norvegicus	23-29
12377780-4	2002	Zn(2+) binding to S100B is sufficient to promote interaction with IQGAP1.	Zinc	0-6	S100 calcium binding protein B	Homo sapiens	18-23
12377780-8	2002	They also reveal an additional cellular function for IQGAP1 associated with Zn(2+)/Ca(2+)-dependent relocation of S100B.	Zinc	76-82	S100 calcium binding protein B	Homo sapiens	114-119
12438619-3	2002	Previous studies have demonstrated that hCycT1 binds Tat in a Zn(2+)-dependent manner via the cysteine at position 261, which is a tyrosine in murine cyclin T1.	Zinc	62-68	cyclin T1	Homo sapiens	40-46
12511101-9	2002	From the kinetic point of view, it is found that the thermal stability of the complexes follows the order Ni(II) &gt; Cu(II) &gt; Zn(II) &gt; Fe(III) &gt; Co(II) &gt; Cd(II).	Zinc	130-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-161
15041280-4	2003	The enzyme was inactivated by Cu(2+) and Zn(2+) and strongly inhibited by typical serine proteinase inhibitors such as TLCK, soybean trypsin inhibitor, aprotinin, benzamidine and alpha-antitrypsin.	Zinc	41-43	kunitz trypsin protease inhibitor	Glycine max	133-150
12209932-5	2002	The relative growth rate of MC3T3-E1 cells cultured on ZnTCP/HAP1.64 had a maximum value of 1.3 at a zinc content of 0.51 wt %; however, a 1.20 Zn wt % is required to attain the same value in relative growth rate in the case of ZnTCP/HAP1.60.	Zinc	55-57	huntingtin-associated protein 1	Mus musculus	61-65
12209932-5	2002	The relative growth rate of MC3T3-E1 cells cultured on ZnTCP/HAP1.64 had a maximum value of 1.3 at a zinc content of 0.51 wt %; however, a 1.20 Zn wt % is required to attain the same value in relative growth rate in the case of ZnTCP/HAP1.60.	Zinc	55-57	huntingtin-associated protein 1	Mus musculus	234-238
12473116-10	2002	The p38MAPK-specific inhibitor SB203580 also inhibited induction of apoptosis by Py/Zn.	Zinc	84-86	mitogen-activated protein kinase 14	Homo sapiens	4-11
12489793-4	2002	The inhibitors activate at the Zn-binding pentameric consensus sequence HEXXH (195 -199) of B1, a motif also present in the active centers of ACE but absent from the BK B2 receptor.	Zinc	31-33	angiotensin I converting enzyme	Homo sapiens	142-145
12510387-8	2002	TCA acted as a tridentate donor for three Zn3L1 at neutral pH to yield a similar type of 4:4 self-assembling supercomplex, in which the deprotonated TCA3- in an aromatic 1,3,5-triazine binds to Zn3L1 through Zn(2+)-S- (exocyclic) coordination bonds, and thus the 4:4 assembly is a chiral twisted cuboctahedron.	Zinc	208-216	C-C motif chemokine ligand 1	Homo sapiens	149-153
12213816-5	2002	The source of liberated Zn(2+) was traced to PKC and particularly the zinc finger domains.	Zinc	24-26	proline rich transmembrane protein 2	Homo sapiens	45-48
12213816-6	2002	The activated form of native PKCalpha contained significantly less Zn(2+) than the resting form.	Zinc	67-69	protein kinase C alpha	Homo sapiens	29-37
12213816-7	2002	Furthermore, purified recombinant PKC protein fragments shed stoichiometric amounts of Zn(2+) upon reaction with diacylglycerol, phorbol ester, or reactive oxygen in vitro.	Zinc	87-89	proline rich transmembrane protein 2	Homo sapiens	34-37
12182317-1	2002	Zn- and to a lesser extent Mg-releasing tricalcium phosphate (Zn- and Mg-TCP) have excellent bioactivities which do not exist in their parent TCP base.	Zinc	0-2	serine peptidase inhibitor Kazal type 1	Homo sapiens	73-76
12367517-7	2002	Marked differences in the specificity of DNA binding were observed for the two subunits of lambda repressor, the glucocorticoid receptor, and for transcription factors containing a Zn(2)Cys(6) binuclear cluster domain, which are known to bind asymmetrically to DNA.	Zinc	181-183	nuclear receptor subfamily 3 group C member 1	Homo sapiens	113-136
12182317-1	2002	Zn- and to a lesser extent Mg-releasing tricalcium phosphate (Zn- and Mg-TCP) have excellent bioactivities which do not exist in their parent TCP base.	Zinc	62-64	serine peptidase inhibitor Kazal type 1	Homo sapiens	142-145
12192006-6	2002	The activity was inhibited by anti-Abeta antibodies, Cu(2+) chelators, and Zn(2+).	Zinc	75-77	amyloid beta precursor protein	Homo sapiens	35-40
12182317-1	2002	Zn- and to a lesser extent Mg-releasing tricalcium phosphate (Zn- and Mg-TCP) have excellent bioactivities which do not exist in their parent TCP base.	Zinc	0-2	serine peptidase inhibitor Kazal type 1	Homo sapiens	142-145
12368662-6	2002	The Zn translocation observed in hippocampus CA1, CA2, and Hilus 72 hours after 20 minutes of TGI was significantly reduced by mild hypothermia.	Zinc	4-6	carbonic anhydrase 2	Mus musculus	50-53
12107071-6	2002	Reducing [Zn(2+)](i), using N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine, caused rapid apoptosis in both p53(wt) and p53(mut) cells, although cotreatment with VP-16 exacerbated apoptosis only in p53(wt) cells.	Zinc	10-16	tumor protein p53	Homo sapiens	111-114
12237343-10	2002	Thus, the Ca(2+)-sensitized homomeric rP2X(5) receptor is similar in agonist profile to homomeric rP2X(1)-although it can be distinguished from the latter by GTP agonism, antagonist profile, and the modulatory effects of H(+) and Zn(2+) ions.	Zinc	230-232	purinergic receptor P2X 5	Rattus norvegicus	38-45
12167209-8	2002	In fine particles, TNF-alpha production was negatively correlated with Zn content, while no element in coarse particles correlated with TNF-alpha production.	Zinc	71-73	tumor necrosis factor	Mus musculus	19-28
12206771-8	2002	Further, the protein binds Zn(II) and Co(II) in the expected manner and shows ferroxidase activity under single turnover conditions.	Zinc	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
12146948-1	2002	To characterize the protein-protein interaction during electron transfer, we used Zn-substituted cytochrome c (ZnCytc) as a model of ferrous Cytc and determined the volume change, DeltaV(d)(Zn), for the dissociation of its complex with ferric cytochrome b(5) (Cytb(5)) by the pressure dependence of its photoinduced electron-transfer kinetics.	Zinc	82-84	cytochrome c, somatic	Homo sapiens	97-109
12500658-7	2002	CONCLUSION: The 10 mg Zn/kg body weight of zinc acetate is more consistent in protecting against CCl4 hepatotoxicity.	Zinc	22-24	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
12154226-6	2002	Although Zn(2+) binding occurs only when the protein is in the reduced form, biochemical analyses show that under oxidative conditions, the GhCesA1 zinc-finger domain and also the full-length protein dimerize via intermolecular disulfide bonds, indicating CesA dimerization can be regulated by redox state.	Zinc	9-15	cellulose synthase A catalytic subunit 8 [UDP-forming]-like	Gossypium hirsutum	140-147
12107071-6	2002	Reducing [Zn(2+)](i), using N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine, caused rapid apoptosis in both p53(wt) and p53(mut) cells, although cotreatment with VP-16 exacerbated apoptosis only in p53(wt) cells.	Zinc	10-16	tumor protein p53	Homo sapiens	123-126
12107071-6	2002	Reducing [Zn(2+)](i), using N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine, caused rapid apoptosis in both p53(wt) and p53(mut) cells, although cotreatment with VP-16 exacerbated apoptosis only in p53(wt) cells.	Zinc	10-16	tumor protein p53	Homo sapiens	123-126
12107071-8	2002	We conclude that the DNA damage-induced transient is p53-independent up to a damage threshold, beyond which competent cells reduce [Zn(2+)](i) before apoptosis.	Zinc	132-138	tumor protein p53	Homo sapiens	53-56
12107071-9	2002	Early stress responses in p53(wt) cells take place in an environment of enhanced Zn(2+) availability.	Zinc	81-87	tumor protein p53	Homo sapiens	26-29
12119362-4	2002	The Zn2+ increase was insensitive to a non-N-methyl-d-aspartate (NMDA) receptor antagonist but was efficiently attenuated by tetrodotoxin or Ca2+-free medium, suggesting that Zn2+ is released by MF synaptic terminals in an activity-dependent manner, and thereafter diffuses extracellularly into the neighboring stratum radiatum.	Zinc	4-8	carbonic anhydrase 2	Rattus norvegicus	141-144
12099681-8	2002	Furthermore, the inhibitory effect of Cu,Zn SOD on cholesterol synthesis was completely abolished when the cells were incubated with Cu,Zn SOD in the presence of bisindoilmaleimide (BDM), an inhibitor of protein kinase C (PKC); moreover, we demonstrated that Cu,Zn SOD as well as apo SOD was able to increase PKC activity.	Zinc	41-43	superoxide dismutase 1	Homo sapiens	44-47
12099681-8	2002	Furthermore, the inhibitory effect of Cu,Zn SOD on cholesterol synthesis was completely abolished when the cells were incubated with Cu,Zn SOD in the presence of bisindoilmaleimide (BDM), an inhibitor of protein kinase C (PKC); moreover, we demonstrated that Cu,Zn SOD as well as apo SOD was able to increase PKC activity.	Zinc	41-43	superoxide dismutase 1	Homo sapiens	139-142
12099681-8	2002	Furthermore, the inhibitory effect of Cu,Zn SOD on cholesterol synthesis was completely abolished when the cells were incubated with Cu,Zn SOD in the presence of bisindoilmaleimide (BDM), an inhibitor of protein kinase C (PKC); moreover, we demonstrated that Cu,Zn SOD as well as apo SOD was able to increase PKC activity.	Zinc	41-43	superoxide dismutase 1	Homo sapiens	139-142
12099681-8	2002	Furthermore, the inhibitory effect of Cu,Zn SOD on cholesterol synthesis was completely abolished when the cells were incubated with Cu,Zn SOD in the presence of bisindoilmaleimide (BDM), an inhibitor of protein kinase C (PKC); moreover, we demonstrated that Cu,Zn SOD as well as apo SOD was able to increase PKC activity.	Zinc	41-43	superoxide dismutase 1	Homo sapiens	139-142
12597030-3	2002	Leaves of both low and high Zn plants showed decrease in chlorophyll concentration and accumulation of lipid peroxides, ascorbate and dehydroascorbate, associated with a decrease in the activity of ascorbate peroxidase and superoxide dismutase.	Zinc	28-30	peroxidase 1	Zea mays	208-218
12119362-4	2002	The Zn2+ increase was insensitive to a non-N-methyl-d-aspartate (NMDA) receptor antagonist but was efficiently attenuated by tetrodotoxin or Ca2+-free medium, suggesting that Zn2+ is released by MF synaptic terminals in an activity-dependent manner, and thereafter diffuses extracellularly into the neighboring stratum radiatum.	Zinc	175-179	carbonic anhydrase 2	Rattus norvegicus	141-144
12079375-1	2002	We have investigated the folding energy landscape of cytochrome c by exploiting the widely different electron-transfer (ET) reactivities of buried and exposed Zn(II)-substituted hemes.	Zinc	159-165	cytochrome c, somatic	Homo sapiens	53-65
12079375-2	2002	An electronically excited Zn-porphyrin in guanidine hydrochloride denatured Zn-substituted cytochrome c (Zn-cyt c) reduces ruthenium(III) hexaammine about ten times faster than when embedded in the fully folded protein.	Zinc	26-28	cytochrome c, somatic	Homo sapiens	91-103
12184736-3	2002	Other metals such as Ni2+, Cd2+, Zn2+ and Co2+ also inhibited the I(NS x P2X7) in concentration-dependent manners.	Zinc	33-37	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	73-77
12184736-8	2002	These results suggest that under physiological and toxicological conditions, metal ions, such as Cu2+, Ni2+, Cd2+, Zn2+ and Co2+, may modulate P2X7 receptor channels as inhibitors.	Zinc	115-119	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	143-156
12044548-2	2002	Zn(2+) also completely inhibited the activation of caspase-3-, caspase-6-, and caspase-9-like proteases in ricin-treated cells, while no significant effect of Zn(2+) on these protease activities was observed when added directly to the lysate of ricin-treated cells, suggesting that Zn(2+) blocks the process of the activation of these caspases rather than the direct inhibition of the already activated enzymes.	Zinc	0-2	caspase 3	Homo sapiens	51-60
11937510-4	2002	We found that mutations at Zn2 or Mg sites had similar effects in PLAP and ECAP but that the environment of the Zn1 ion in PLAP is less affected by substitutions than that in ECAP.	Zinc	27-30	alkaline phosphatase, placental	Homo sapiens	66-70
12051660-3	2002	Equivalent fluxes of NO-, and NO + O2- were able to comparably oxidize NADPH, but the oxidation by NO + O2- was more than fivefold more sensitive to inhibition by Cu, Zn SOD than was the oxidation by NO-.	Zinc	167-169	superoxide dismutase 1	Homo sapiens	170-173
12047181-7	2002	Binding constants in toluene solution increase in the order Fe(II) &lt; Pd(II) &lt; Zn(II) &lt; Mn(II) &lt; Co(II) &lt; Cu(II) &lt; 2H and span the range 490-5200 M-1.	Zinc	84-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-114
12050010-6	2002	DNA-binding affinity of p12 was in the nanomolar range, and decreased 14-fold after Zn++ ejection.	Zinc	84-88	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	24-27
11940571-4	2002	Although Zn2+ inhibited uptake, Zn2+ facilitated [3H]MPP+ release induced by amphetamine, MPP+, or K+-induced depolarization specifically at hDAT but not at the human serotonin and the norepinephrine transporter (hNET).	Zinc	32-36	solute carrier family 6 member 2	Homo sapiens	185-211
11880373-4	2002	These inhibitors activate at the Zn(2+)-binding consensus sequence HEXXH (195-199) in B(1), which is present also in ACE but not in the B(2) receptor.	Zinc	33-39	angiotensin I converting enzyme	Homo sapiens	117-120
12015417-0	2002	Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+).	Zinc	99-101	potassium voltage-gated channel subfamily A member 5	Homo sapiens	50-55
12015417-1	2002	Using human Kv1.5 channels expressed in HEK293 cells we assessed the ability of H+o to mimic the previously reported action of Zn(2+) to inhibit macroscopic hKv1.5 currents, and using site-directed mutagenesis, we addressed the mechanistic basis for the inhibitory effects of H(+)(o) and Zn(2+).	Zinc	127-129	potassium voltage-gated channel subfamily A member 5	Homo sapiens	157-163
11880373-7	2002	Thus, Zn(2+) is essential for B(1) receptor activation by ACE inhibitors at the zinc-binding consensus sequence.	Zinc	6-12	bradykinin receptor B1	Homo sapiens	30-43
11880373-7	2002	Thus, Zn(2+) is essential for B(1) receptor activation by ACE inhibitors at the zinc-binding consensus sequence.	Zinc	6-12	angiotensin I converting enzyme	Homo sapiens	58-61
11943669-9	2002	In summary, exposure to As, Zn, and V initiated EGFR signaling and Ras-dependent activation of MEK1/2 and ERK1/2, but only V induced Ras-dependent NF-kappaB nuclear translocation.	Zinc	28-30	epidermal growth factor receptor	Homo sapiens	48-52
11943669-9	2002	In summary, exposure to As, Zn, and V initiated EGFR signaling and Ras-dependent activation of MEK1/2 and ERK1/2, but only V induced Ras-dependent NF-kappaB nuclear translocation.	Zinc	28-30	mitogen-activated protein kinase 3	Homo sapiens	106-112
11943669-9	2002	In summary, exposure to As, Zn, and V initiated EGFR signaling and Ras-dependent activation of MEK1/2 and ERK1/2, but only V induced Ras-dependent NF-kappaB nuclear translocation.	Zinc	28-30	nuclear factor kappa B subunit 1	Homo sapiens	147-156
14612279-10	2002	CONCLUSIONS: Zn2+, as a potent and feasible inducer of HSP expression, is able to protect the liver for cold preservation.	Zinc	13-17	selenoprotein K	Rattus norvegicus	55-58
12065635-2	2002	Recombinant NR1/NR2A subtype NMDA receptor channels are potentiated by the protein tyrosine kinase Src, an effect which is mediated by a reduction in the high-affinity, voltage-independent Zn(2+) inhibition.	Zinc	189-191	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	12-15
12065635-2	2002	Recombinant NR1/NR2A subtype NMDA receptor channels are potentiated by the protein tyrosine kinase Src, an effect which is mediated by a reduction in the high-affinity, voltage-independent Zn(2+) inhibition.	Zinc	189-191	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	16-20
12065635-2	2002	Recombinant NR1/NR2A subtype NMDA receptor channels are potentiated by the protein tyrosine kinase Src, an effect which is mediated by a reduction in the high-affinity, voltage-independent Zn(2+) inhibition.	Zinc	189-191	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	99-102
12065635-5	2002	Here we demonstrate that PSD-95 eliminates the Src-induced potentiation of NR1/NR2A channels expressed in oocytes and reduces the sensitivity of the channels to Zn(2+).	Zinc	161-163	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	47-50
12065635-5	2002	Here we demonstrate that PSD-95 eliminates the Src-induced potentiation of NR1/NR2A channels expressed in oocytes and reduces the sensitivity of the channels to Zn(2+).	Zinc	161-163	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	75-78
12065635-5	2002	Here we demonstrate that PSD-95 eliminates the Src-induced potentiation of NR1/NR2A channels expressed in oocytes and reduces the sensitivity of the channels to Zn(2+).	Zinc	161-163	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	79-83
12012042-5	2002	The control cells without the gene transfection developed characteristic apoptotic changes both morphologically and biochemically when they were incubated with SIN-1 of 200 M. However, the cells showed necrosis predominantly when the concentration of SIN-1 was 1,000 M. On the other hand, the cells transfected with h-Cu, Zn-SOD showed significantly less evidence of apoptotic change after exposure to SIN-1.	Zinc	322-324	MAPK associated protein 1	Homo sapiens	251-256
12175775-3	2002	Assays of aggregation of human prolactin and growth hormone in neuroendocrine cells indicate that acidic intracellular compartments are necessary, and Zn2+ and Cu2+ may facilitate aggregation through low affinity binding sites.	Zinc	151-155	prolactin	Homo sapiens	31-40
11978914-6	2002	RESULTS: Zrs could be reliably partitioned into Zn and Zlrs.	Zinc	48-50	limb development membrane protein 1	Homo sapiens	9-12
11805091-6	2002	The dose-response curve for Zn(2+) inhibition was identical for AC1, AC5, and AC6 as well as for the C441R mutant of AC5 whose defect appears to be in one of the catalytic metal binding sites.	Zinc	28-30	adenylate cyclase 6	Mus musculus	78-81
11897686-5	2002	In solution, purified recombinant human PRL was precipitated by 20 microM Cu(2+) or Zn(2+).	Zinc	84-86	prolactin	Homo sapiens	40-43
11942673-7	2002	Mean percentages of the individual components in MIG/Al fumes/dusts were Al: 30 (9-56) percent; Mg: 3 (1-5.6) percent; Mn: 0.2 (0.1-0.3) percent; Cu: 0.2 (&lt; 0.1-1.8) percent; Zn: 0.2 (&lt; 0.1-0.8) percent; Pb: 0.2 (&lt; 0.1-1) percent; Cr: &lt; 0.1 percent.	Zinc	178-180	C-X-C motif chemokine ligand 9	Homo sapiens	49-52
11867528-5	2002	Electrophysiological analysis revealed that the modulation of GABA-induced Cl- current by Zn2+ or diazepam, both of which act at GABA(A) receptors containing gamma subunits, is impaired in hippocampal neurons of p130 knockout mice.	Zinc	90-94	nucleolar and coiled-body phosphoprotein 1	Mus musculus	212-216
11896678-8	2002	The results revealed a strong inhibitory potential of Cu(II) [0.4], followed by Ni(II) [3.5] &gt;or= Zn(II) [7.0] &gt;&gt; Cr(III) [73] &gt; Cd(II) [98] &gt;&gt; Co(II) [432] [the numbers in brackets are IC(50) values, microM].	Zinc	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
12089889-4	2002	Positive correlation was shown between serum Zn level and prealbumin, iron, transferrin saturation, haemoglobin, mean corpuscular haemoglobin concentration and dialysis duration.	Zinc	45-47	transferrin	Homo sapiens	76-87
11781329-4	2002	Fluorescence spectroscopy of a cyt c analog containing a Zn(2+) substituted heme moiety and brominated lipid derivatives (9,10)-dibromostearate and 1-palmitoyl-2-(9,10)-dibromo-sn-glycero-3-phospho-rac-glycerol demonstrated a direct contact between the fluorescent [Zn(2+)-heme] group and the brominated acyl chain.	Zinc	57-63	cytochrome c, somatic	Homo sapiens	31-36
11863429-11	2002	Therefore, this study provides structural hints for understanding the origin of the enzymatic behavior of the Zn-deficient SOD.	Zinc	110-112	superoxide dismutase 1	Homo sapiens	123-126
11817952-5	2002	FluoZin-3 was used to monitor Zn2+ that was co-secreted with insulin from pancreatic beta-cells by exocytosis following stimulation with glucose.	Zinc	30-34	insulin	Homo sapiens	61-68
12018613-7	2002	Cdcolli III F6 showed allosteric enzymatic behavior, with maximal activity at pH 8.3 and 36 degrees C. Full PLA2 activity required the presence of a low Ca2+ concentration and was inhibited by Cu2+ and Zn2+ and by Cu2+ and Mg2+ in the presence and absence of Ca2+, respectively.	Zinc	202-206	phospholipase A2, group V	Mus musculus	108-112
11814329-9	2002	Concomitantly, MT1 protein levels in MTF1dko7 cells were inducible to the same degree as that in Hepa-1 cells when treated with Zn(2+), but not with Cd(2+).	Zinc	128-130	metallothionein 1	Mus musculus	15-18
11850455-0	2002	Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons.	Zinc	94-98	carbonic anhydrase 2	Mus musculus	12-15
11850455-2	2002	Studies in cultured neurons have revealed that of the three major routes of divalent cation entry, NMDA channels, voltage-sensitive Ca2+ channels (VSCCs), and Ca2+-permeable AMPA/kainate (Ca-A/K) channels, Ca-A/K channels exhibit the highest permeability to exogenously applied Zn2+.	Zinc	278-282	carbonic anhydrase 2	Mus musculus	159-162
11850455-7	2002	Whereas strong Zn2+ labeling persisted if both the NMDA antagonist MK-801 and the VSCC blocker Gd3+ were present during OGD, the presence of either the Ca-A/K channel blocker 1-naphthyl acetyl spermine (NAS) or the extracellular Zn2+ chelator Ca2+ EDTA substantially decreased Zn2+ accumulation in pyramidal neurons of both subregions.	Zinc	15-19	carbonic anhydrase 2	Mus musculus	243-246
11781144-2	2002	The binding of zinc to human alpha-fetoprotein (AFP) isolated from human umbilical cord serum was studied by fluorimetric Zn(2+)-titration.	Zinc	122-124	alpha fetoprotein	Homo sapiens	29-46
11779168-5	2002	Furthermore, fluorescence spectroscopy revealed that only Co(2+) and Ni(2+) have the binding activity to cullin-2, but other metal ions, including Cu(2+), Ca(2+), Mg(2+), Mn(2+), and Zn(2+), did not.	Zinc	183-185	cullin 2	Homo sapiens	105-113
11781144-2	2002	The binding of zinc to human alpha-fetoprotein (AFP) isolated from human umbilical cord serum was studied by fluorimetric Zn(2+)-titration.	Zinc	122-124	alpha fetoprotein	Homo sapiens	48-51
12812047-5	2002	It is suggested that significantly elevated plasma nociceptin level is due to the inhibition of nociceptin-inactivating Zn-metallopeptidases (aminopeptidase N, endopeptidase 24.15) by the toxic copper levels, as it is known that changing the central Zn atom to Cu results in an approximately 50% inhibition in the activity of these enzymes.	Zinc	120-122	prepronociceptin	Homo sapiens	51-61
12812047-5	2002	It is suggested that significantly elevated plasma nociceptin level is due to the inhibition of nociceptin-inactivating Zn-metallopeptidases (aminopeptidase N, endopeptidase 24.15) by the toxic copper levels, as it is known that changing the central Zn atom to Cu results in an approximately 50% inhibition in the activity of these enzymes.	Zinc	120-122	prepronociceptin	Homo sapiens	96-106
11747305-7	2002	Second, while autophosphorylation did not affect Src activation by free Mg(2+), Zn(2+), which inhibited Src by competing against an essential Mg(2+) activator, inhibited the control threefold more potently than the autophosphorylated form.	Zinc	80-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-107
12095159-3	2002	Thus, this work explored the ability of Zn to protect human neurons in culture (NT2-N) from Cu-mediated death and tested the hypotheses that the tumor-suppressor protein p53 plays a role in Cu-induced neuronal death and is part of the mechanism of Zn protection.	Zinc	248-250	tumor protein p53	Homo sapiens	170-173
11866117-6	2002	These results indicate that carnosine and such related compounds as Gly-His and Ala-His are effective anti-glycating agents for human Cu,Zn-SOD and that the effectiveness is based not only on high reactivity with carbonyl compounds but also on hydroxyl radical scavenging activity.	Zinc	137-139	superoxide dismutase 1	Homo sapiens	140-143
12095159-5	2002	However, the addition of 700 microM Zn to Cu-treated cells resulted in neuronal viability that was not different from untreated controls through 24 h. p53 mRNA abundance, while increased by the addition of Cu and 100 microM Zn, was decreased to 50% of control with the addition of 500 microM Zn in Cu-treated cells, and to 10% of control with 700 microM Zn.	Zinc	36-38	tumor protein p53	Homo sapiens	151-154
12095159-5	2002	However, the addition of 700 microM Zn to Cu-treated cells resulted in neuronal viability that was not different from untreated controls through 24 h. p53 mRNA abundance, while increased by the addition of Cu and 100 microM Zn, was decreased to 50% of control with the addition of 500 microM Zn in Cu-treated cells, and to 10% of control with 700 microM Zn.	Zinc	224-226	tumor protein p53	Homo sapiens	151-154
12095159-5	2002	However, the addition of 700 microM Zn to Cu-treated cells resulted in neuronal viability that was not different from untreated controls through 24 h. p53 mRNA abundance, while increased by the addition of Cu and 100 microM Zn, was decreased to 50% of control with the addition of 500 microM Zn in Cu-treated cells, and to 10% of control with 700 microM Zn.	Zinc	224-226	tumor protein p53	Homo sapiens	151-154
12095159-5	2002	However, the addition of 700 microM Zn to Cu-treated cells resulted in neuronal viability that was not different from untreated controls through 24 h. p53 mRNA abundance, while increased by the addition of Cu and 100 microM Zn, was decreased to 50% of control with the addition of 500 microM Zn in Cu-treated cells, and to 10% of control with 700 microM Zn.	Zinc	224-226	tumor protein p53	Homo sapiens	151-154
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	44-46	tumor protein p53	Homo sapiens	73-76
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	44-46	tumor protein p53	Homo sapiens	170-173
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	44-46	tumor protein p53	Homo sapiens	170-173
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	110-112	tumor protein p53	Homo sapiens	73-76
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	110-112	tumor protein p53	Homo sapiens	170-173
12095159-8	2002	Furthermore, the addition of 500-700 microM Zn prevented the movement of p53 into the nucleus suggesting that Zn not only protects neurons from Cu toxicity by regulating p53 mRNA abundance but also by preventing the translocation of p53 to the nucleus.	Zinc	110-112	tumor protein p53	Homo sapiens	170-173
11735476-0	2001	Tris(pyridinealdoximato)metal complexes as ligands for the synthesis of asymmetric heterodinuclear Cr(III)M species [M = Zn(II), Cu(II), Ni(II), Fe(II), Mn(II), Cr(II), Co(III)]: a magneto-structural study.	Zinc	121-127	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	102-105
11595748-7	2001	Further experiments compared the abilities of Zn(2+) and Ca(2+) to induce mitochondrial release of cytochrome c (Cyt-c) or apoptosis-inducing factor.	Zinc	46-48	cytochrome c, somatic	Homo sapiens	99-111
11595748-7	2001	Further experiments compared the abilities of Zn(2+) and Ca(2+) to induce mitochondrial release of cytochrome c (Cyt-c) or apoptosis-inducing factor.	Zinc	46-48	cytochrome c, somatic	Homo sapiens	113-118
11595748-8	2001	In isolated mitochondria, 10 nm Zn(2+) exposures induced Cyt-c release.	Zinc	32-34	cytochrome c, somatic	Homo sapiens	57-62
11595748-9	2001	Induction of Zn(2+) entry into cortical neurons resulted in distinct increases in cytosolic Cyt-c immunolabeling and in cytosolic and nuclear apoptosis-inducing factor labeling within 60 min.	Zinc	13-19	cytochrome c, somatic	Homo sapiens	92-97
11770796-14	2001	Although nephrectomized groups" PTH levels were increased compared to S controls, PTH levels were increased in +Zn/N animals compared to the -Zn/N group.	Zinc	112-114	parathyroid hormone	Rattus norvegicus	82-85
11739784-6	2001	Zn(2+)-binding and mutagenesis experiments indicate that APC11 binds Zn(2+) at a 1:3 M ratio.	Zinc	0-6	anaphase promoting complex subunit 11	Homo sapiens	57-62
11739784-6	2001	Zn(2+)-binding and mutagenesis experiments indicate that APC11 binds Zn(2+) at a 1:3 M ratio.	Zinc	69-75	anaphase promoting complex subunit 11	Homo sapiens	57-62
11739784-7	2001	Unlike the two Zn(2+) ions of the canonical RING-finger motif, the third Zn(2+) ion of APC11 is not essential for its ligase activity.	Zinc	73-75	anaphase promoting complex subunit 11	Homo sapiens	87-92
11739637-6	2001	The isoform lacks the 12th exon, which produced a frame-shift and gave a shorter form of HIF-1alpha (557 amino acids), designated HIF-1alphaZ (HIF-1alpha induced by Zn).	Zinc	165-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
11546769-0	2001	Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain.	Zinc	50-56	dimethylarginine dimethylaminohydrolase 1	Bos taurus	65-85
11546769-0	2001	Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain.	Zinc	50-56	dimethylarginine dimethylaminohydrolase 1	Bos taurus	87-93
11546769-1	2001	Zn(II) release activates DDAH-1.	Zinc	0-6	dimethylarginine dimethylaminohydrolase 1	Bos taurus	25-31
11546769-2	2001	L-N(omega),N(omega)-dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is a Zn(II)-containing enzyme that, through hydrolysis of side-chain methylated l-arginines, regulates the activity of nitric-oxide synthase.	Zinc	76-82	dimethylarginine dimethylaminohydrolase 1	Bos taurus	0-61
11546769-2	2001	L-N(omega),N(omega)-dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is a Zn(II)-containing enzyme that, through hydrolysis of side-chain methylated l-arginines, regulates the activity of nitric-oxide synthase.	Zinc	76-82	dimethylarginine dimethylaminohydrolase 1	Bos taurus	63-69
11546769-3	2001	Herein we report the structural and functional properties of the Zn(II)-binding site in DDAH-1 from bovine brain.	Zinc	65-71	dimethylarginine dimethylaminohydrolase 1	Bos taurus	88-94
11546769-5	2001	Native DDAH-1 could be fully or partially activated using various concentrations of phosphate, imidazole, histidine, and histamine, a process that is paralleled by the release of Zn(II).	Zinc	179-181	dimethylarginine dimethylaminohydrolase 1	Bos taurus	7-13
11546769-9	2001	The coordination environment of the Zn(II) in DDAH-1 has been examined by Zn K-edge x-ray absorption spectroscopy.	Zinc	36-42	dimethylarginine dimethylaminohydrolase 1	Bos taurus	46-52
11689476-5	2001	It is suggested that iNOS-derived NO acts as a signal molecule targeting cysteine-Zn2+ linkages, thus enabling cells to react toward nitrosative stress.	Zinc	82-86	nitric oxide synthase 2	Homo sapiens	21-25
11739637-6	2001	The isoform lacks the 12th exon, which produced a frame-shift and gave a shorter form of HIF-1alpha (557 amino acids), designated HIF-1alphaZ (HIF-1alpha induced by Zn).	Zinc	165-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
11881740-3	2001	These mutations structurally weaken SOD, which indirectly decreases its affinity for Zn.	Zinc	85-87	superoxide dismutase 1	Homo sapiens	36-39
11588174-0	2001	Induction of mossy fiber --&gt; Ca3 long-term potentiation requires translocation of synaptically released Zn2+.	Zinc	107-111	carbonic anhydrase 3	Homo sapiens	32-35
11588174-8	2001	These results indicate that synaptically released Zn(2+), acting as a second messenger, is necessary for the induction of LTP at mossy fiber--&gt;CA3 synapses of hippocampus.	Zinc	50-52	carbonic anhydrase 3	Homo sapiens	146-149
11576872-1	2001	In this study we investigated the contribution of Zn ions to the catalytic and structural thermostability of carboxypeptidase A (CPA).	Zinc	50-52	carboxypeptidase A1	Homo sapiens	109-127
11576872-1	2001	In this study we investigated the contribution of Zn ions to the catalytic and structural thermostability of carboxypeptidase A (CPA).	Zinc	50-52	carboxypeptidase A1	Homo sapiens	129-132
11576872-2	2001	Structural studies on CPA molecule, performed in the presence of a number of ligands, demonstrated the multiple binding models around Zn ions which may affect the enzyme functions.	Zinc	134-136	carboxypeptidase A1	Homo sapiens	22-25
11576872-4	2001	In this study we found that binding of Zn to CPA molecule followed by exposure to 50 degrees C did not inhibit the enzymic activity but activates and protects it against heat denaturation.	Zinc	39-41	carboxypeptidase A1	Homo sapiens	45-48
11576872-5	2001	The stabilization effect was found to be dependent on the increasing Zn/CPA ratios.	Zinc	69-71	carboxypeptidase A1	Homo sapiens	72-75
11881740-4	2001	Zn-deficient SOD induces apoptosis in motoneurons through a mechanism involving peroxynitrite.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	13-16
11881740-5	2001	Importantly, Zn-deficient wild-type SOD is just as toxic as Zn-deficient ALS mutant SOD, suggesting that the loss of Zn from wild-type SOD could be involved in the other 98% of cases of ALS.	Zinc	13-15	superoxide dismutase 1	Homo sapiens	36-39
11881740-5	2001	Importantly, Zn-deficient wild-type SOD is just as toxic as Zn-deficient ALS mutant SOD, suggesting that the loss of Zn from wild-type SOD could be involved in the other 98% of cases of ALS.	Zinc	60-62	superoxide dismutase 1	Homo sapiens	84-87
11881740-5	2001	Importantly, Zn-deficient wild-type SOD is just as toxic as Zn-deficient ALS mutant SOD, suggesting that the loss of Zn from wild-type SOD could be involved in the other 98% of cases of ALS.	Zinc	60-62	superoxide dismutase 1	Homo sapiens	84-87
11881740-6	2001	Zn-deficient SOD could therefore be an important therapeutic target in all forms of ALS.	Zinc	0-2	superoxide dismutase 1	Homo sapiens	13-16
11606206-9	2001	The activity of the nematode AP-P, like its mammalian counterparts, was strongly influenced by metal ions, with Co2+, Mn2+ and Zn2+ all inhibiting the hydrolysis of bradykinin.	Zinc	127-131	kininogen 1	Homo sapiens	165-175
11457851-5	2001	This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e. ASIC2a, ASIC1a+2a, ASIC2a+3), but not of homomeric ASIC1a and ASIC3.	Zinc	22-24	acid sensing ion channel subunit 2	Homo sapiens	90-96
11461912-8	2001	The reverse reaction, i.e. the reduction of NO to NO(-) by Cu(I),Zn-SOD, followed by the reaction of NO(-) with O(2) would yield ONOO(-) and that could explain the oxidation of dichlorofluorescin (DCF) by Cu(I),Zn-SOD plus NO.	Zinc	65-67	superoxide dismutase 1	Homo sapiens	68-71
11461912-8	2001	The reverse reaction, i.e. the reduction of NO to NO(-) by Cu(I),Zn-SOD, followed by the reaction of NO(-) with O(2) would yield ONOO(-) and that could explain the oxidation of dichlorofluorescin (DCF) by Cu(I),Zn-SOD plus NO.	Zinc	65-67	superoxide dismutase 1	Homo sapiens	214-217
11457851-5	2001	This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e. ASIC2a, ASIC1a+2a, ASIC2a+3), but not of homomeric ASIC1a and ASIC3.	Zinc	22-24	acid sensing ion channel subunit 2	Homo sapiens	123-129
11457851-5	2001	This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e. ASIC2a, ASIC1a+2a, ASIC2a+3), but not of homomeric ASIC1a and ASIC3.	Zinc	22-24	acid sensing ion channel subunit 2	Homo sapiens	123-129
11457851-6	2001	The EC(50) for Zn(2+) potentiation is 120 and 111 microm for the ASIC2a and ASIC1a+2a current, respectively.	Zinc	15-17	acid sensing ion channel subunit 2	Homo sapiens	65-71
11457851-8	2001	Systematic mutagenesis of the 10 extracellular histidines of ASIC2a leads to the identification of two residues (His-162 and His-339) that are essential for the Zn(2+) potentiating effect.	Zinc	161-163	acid sensing ion channel subunit 2	Homo sapiens	61-67
11831462-7	2001	Studies by our laboratory in airway epithelial cells show that Zn is co-localized with the precursor form of caspase-3, mitochondria and microtubules, suggesting this Zn is critically placed to control apoptosis.	Zinc	63-65	caspase 3	Homo sapiens	109-118
11526318-3	2001	SEC2 contains a zinc-binding motif, D+HExxH, and accordingly a Zn atom has been identified.	Zinc	63-65	fucosyltransferase 2	Homo sapiens	0-4
12552810-4	2001	Some properties of the enzyme such as the sensitivity to thiol reagent and the effects of metal ions, for instance inhibited by Zn2+ and activited by Mn2+, Mg2+ are identical to dihydropyrimidinase.	Zinc	128-132	dihydropyrimidinase	Homo sapiens	178-197
11831462-7	2001	Studies by our laboratory in airway epithelial cells show that Zn is co-localized with the precursor form of caspase-3, mitochondria and microtubules, suggesting this Zn is critically placed to control apoptosis.	Zinc	167-169	caspase 3	Homo sapiens	109-118
11483654-1	2001	It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation.	Zinc	57-61	nerve growth factor	Homo sapiens	101-120
11486018-1	2001	Sip4 is a Zn(2)Cys(6) transcriptional activator that binds to the carbon source-responsive elements of gluconeogenic genes in Saccharomyces cerevisiae.	Zinc	10-15	Sip4p	Saccharomyces cerevisiae S288C	0-4
11402046-0	2001	Intracellular Ca2+ and Zn2+ levels regulate the alternative cell density-dependent secretion of S100B in human glioblastoma cells.	Zinc	23-27	S100 calcium binding protein B	Homo sapiens	96-101
11402046-7	2001	In contrast, relocation of S100B seemed to be negatively dependent on Zn(2+) levels.	Zinc	70-76	S100 calcium binding protein B	Homo sapiens	27-32
11402046-8	2001	Treatment of cells with TPEN (N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine), a Zn(2+)-binding drug, resulted in a dramatic redistribution and translocation of S100B.	Zinc	85-87	S100 calcium binding protein B	Homo sapiens	165-170
11402046-11	2001	However, an increase in Ca(2+) levels, and even more so, a decrease in Zn(2+) concentration, reactivated secretion of S100B.	Zinc	71-77	S100 calcium binding protein B	Homo sapiens	118-123
11483663-0	2001	Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.	Zinc	0-4	Eph receptor B1	Rattus norvegicus	13-16
11483654-1	2001	It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation.	Zinc	57-61	nerve growth factor	Homo sapiens	122-125
11483663-4	2001	Intracellular accumulation of Zn2+ induced by the combined application of pyrithione (5 microM), a Zn2+ ionophore, and Zn2+ (10 microM) caused cell death and activated JNK and ERK, but not p38 MAPK.	Zinc	30-34	Eph receptor B1	Rattus norvegicus	176-179
11483654-5	2001	The inhibitory effect of Zn2+ on biological activities of NGF is lost under acidic conditions.	Zinc	25-29	nerve growth factor	Homo sapiens	58-61
11483663-7	2001	Intracellular Zn2+ accumulation resulted in the generation of ROS, and antioxidants prevented both the ERK activation and the cell death induced by Zn2+.	Zinc	14-18	Eph receptor B1	Rattus norvegicus	103-106
11483654-8	2001	These findings suggest that cerebral acidosis associated with stroke or traumatic brain injury could neutralize the Zn2+-mediated inactivation of NGF, whereas corresponding pH changes would have little or no influence on the inhibitory effects of Cu2+.	Zinc	116-120	nerve growth factor	Homo sapiens	146-149
11483663-8	2001	Therefore, we conclude that although Zn2+ activates JNK and ERK, only ERK contributes to Zn2+-induced cell death, and that ERK activation is mediated by ROS via the Ras/Raf/MEK/ERK signaling pathway.	Zinc	37-41	Eph receptor B1	Rattus norvegicus	60-63
11404220-13	2001	Our results and the results of others suggest that zinc acts at multiple steps in amino acid- and insulin cell-signaling pathways, including mTOR, and that the additive effects of Zn2+ on these steps may thereby promote insulin and nutritional signaling.	Zinc	180-184	insulin	Homo sapiens	220-227
11434776-13	2001	Therefore, Cu(2+) and/or Zn(2+) binding is critical for PrP106-126 aggregation and neurotoxicity.	Zinc	25-31	prion protein	Homo sapiens	56-66
11551383-0	2001	Interaction of Cu(2+) with His-Val-His and of Zn(2+) with His-Val-Gly-Asp, two peptides surrounding metal ions in Cu,Zn-superoxide dismutase enzyme.	Zinc	46-48	superoxide dismutase 1	Homo sapiens	114-140
11423399-5	2001	The presence of cysteines at the Q/R/N site in both subunits of NR1/NR2C receptors results in a 220,000-fold increase in sensitivity of the inhibition by extracellular Zn.	Zinc	168-170	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	64-67
11423399-6	2001	In contrast with the high-affinity Zn inhibition of wild-type NR1/NR2A receptors, the high-affinity Zn inhibition of mutated NR1/NR2C receptors shows a voltage dependence, which resembles very much that of the block by extracellular Mg.	Zinc	100-102	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	125-128
11423401-2	2001	In Kv1.5, Zn(2+) also reduces ionic current, and this is relieved by increasing the external K(+) or Cs(+) concentration.	Zinc	10-16	potassium voltage-gated channel subfamily A member 5	Homo sapiens	3-8
11423401-3	2001	Here we have investigated the actions of Zn(2+) on the gating currents of Kv1.5 channels expressed in HEK cells.	Zinc	41-43	potassium voltage-gated channel subfamily A member 5	Homo sapiens	74-79
11312263-4	2001	AHNAK binds to S100B-Sepharose beads and is also recovered in anti-S100B immunoprecipitates in a strict Ca(2+)- and Zn(2+)-dependent manner.	Zinc	116-122	AHNAK nucleoprotein	Rattus norvegicus	0-5
11447848-2	2001	Hg, Cu, and Zn concentrations in ground water ranged from 0.07 to 4.6 ng L-1, 0.07 to 3.10 micrograms L-1, and 0.17 to 2.18 micrograms L-1, respectively.	Zinc	12-14	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-49	AHNAK nucleoprotein	Rattus norvegicus	108-113
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-53	AHNAK nucleoprotein	Rattus norvegicus	108-113
11399088-3	2001	We have purified and characterized individual domains of Dnmt1 (NLS-containing domain, NlsD, amino acid residues: 1-343; replication foci-directing domain, 350-609; Zn-binding domain (ZnD), 613-748; polybromo domain, 746-1110; and the catalytic domain (CatD), 1124-1620).	Zinc	165-167	DNA methyltransferase (cytosine-5) 1	Mus musculus	57-62
11399088-12	2001	This effect is dependent on Zn, suggesting that binding of methylated DNA to ZnD triggers the allosteric activation of the catalytic center of Dnmt1.	Zinc	28-30	DNA methyltransferase (cytosine-5) 1	Mus musculus	143-148
11399060-5	2001	Caspase-3 activity was found to resume upon mild Zn(2+) chelation.	Zinc	49-55	caspase 3	Homo sapiens	0-9
11414818-4	2001	The same mutant of carbonic anhydrase containing Zn(II) had the rate of release of H(2)(18)O smaller by 10-fold, but rate of interconversion of CO(2) and HCO(3)(-) about the same as the Co(II)-containing enzyme.	Zinc	49-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
11274207-2	2001	Cu(2+) and Zn(2+) bind Abeta, inducing aggregation and giving rise to reactive oxygen species.	Zinc	11-13	amyloid beta precursor protein	Homo sapiens	23-28
11274207-7	2001	Addition of Cu(2+) or Zn(2+) to Abeta in a negatively charged lipid environment caused a conformational change from beta-sheet to alpha-helix, accompanied by peptide oligomerization and membrane penetration.	Zinc	22-24	amyloid beta precursor protein	Homo sapiens	32-37
11306655-2	2001	We used the whole-cell recording technique to examine the effect of extracellular Zn(2+) on macroscopic currents due to Kv1.5 channels expressed in the human embryonic kidney cell line HEK293.	Zinc	82-84	potassium voltage-gated channel subfamily A member 5	Homo sapiens	120-125
11279142-7	2001	The latter data were further supported by time-resolved spectroscopy using the fluorescent cyt c analog with a Zn(2+)-substituted heme moiety.	Zinc	111-117	cytochrome c, somatic	Homo sapiens	91-96
11470313-7	2001	The Menkes and Wilson proteins have been characterized as copper transporters and the amyloid precursor protein (APP) of Alzheimer"s disease has been proposed to work as a Cu(II) and/or Zn(II) transporter.	Zinc	186-188	amyloid beta precursor protein	Homo sapiens	86-111
11330996-9	2001	Considering only the high-affinity site, there is a diminution in the enthalpy of binding through the series Co(II) --&gt; Zn(II) --&gt; Cu(II) that mirrors the enthalpy of hydration; this observation reinforces the notion that the thermodynamics of solute association with water is at least as important as the thermodynamics of solute-solute interaction and that these effects must be considered when interpreting association in aqueous solution.	Zinc	123-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
11312158-3	2001	The expression of the antiapoptotic protein phosphorylated Bad was markedly increased, whereas the expression of the proapoptotic proteins Bax and Bad decreased following Zn(2+) exposure.	Zinc	171-173	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142
11312158-4	2001	Zn(2+) induced rapid degradation of IkappaB, and an increase in the binding of nuclear transcription factor-kappaB (NF-kappaB).	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	79-114
11312158-4	2001	Zn(2+) induced rapid degradation of IkappaB, and an increase in the binding of nuclear transcription factor-kappaB (NF-kappaB).	Zinc	0-2	nuclear factor kappa B subunit 1	Homo sapiens	116-125
11306679-0	2001	Zn(2+) induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-Kinase.	Zinc	0-2	mitogen-activated protein kinase 8	Homo sapiens	34-57
11306679-5	2001	Exposure of cells to Zn(2+) resulted in the stimulation of JNK and its upstream kinases including stress-activated protein kinase kinase and mitogen-activated protein kinase kinase kinase.	Zinc	21-23	mitogen-activated protein kinase 8	Homo sapiens	59-62
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	Zinc	0-2	mitogen-activated protein kinase 8	Homo sapiens	87-90
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	Zinc	0-6	mitogen-activated protein kinase 8	Homo sapiens	87-90
11306679-7	2001	Furthermore, overexpression of Rac1N17, a dominant negative mutant of Rac1, suppressed the Zn(2+)- and PI3Kgamma-induced JNK stimulation.	Zinc	91-93	mitogen-activated protein kinase 8	Homo sapiens	121-124
11306679-8	2001	The stimulatory effect of Zn(2+) on both PI3K and JNK was repressed by the free-radical scavenging agent N-acetylcysteine.	Zinc	26-32	mitogen-activated protein kinase 8	Homo sapiens	50-53
11306679-9	2001	Taken together, our data suggest that Zn(2+) induces stimulation of the JNK signaling pathway through PI3K-Rac1 signals and that the free-radical generation may be an important step in the Zn(2+) induction of the JNK stimulation.	Zinc	38-44	mitogen-activated protein kinase 8	Homo sapiens	72-75
11306679-9	2001	Taken together, our data suggest that Zn(2+) induces stimulation of the JNK signaling pathway through PI3K-Rac1 signals and that the free-radical generation may be an important step in the Zn(2+) induction of the JNK stimulation.	Zinc	38-44	mitogen-activated protein kinase 8	Homo sapiens	213-216
11306679-9	2001	Taken together, our data suggest that Zn(2+) induces stimulation of the JNK signaling pathway through PI3K-Rac1 signals and that the free-radical generation may be an important step in the Zn(2+) induction of the JNK stimulation.	Zinc	189-195	mitogen-activated protein kinase 8	Homo sapiens	213-216
11336800-8	2001	Although we were able to demonstrate that [His(10)]-PTH(1-14) binds Zn(II) using (1)H-NMR, our spectroscopic studies (circular dichroism and nuclear magnetic resonance) were not consistent with the notion that zinc enhanced the activity of [His(10)]-PTH(1-14) simply by inducing a helical structure in the 10-14 region.	Zinc	68-70	parathyroid hormone	Rattus norvegicus	52-55
11368166-6	2001	Such oxidations catalyzed by Cu,Zn SOD could account for the deleterious effects of the mutant Cu,Zn SODs associated with familial amyotrophic lateral sclerosis and of the overproduction or overadministration of wild-type Cu,Zn SOD.	Zinc	32-34	superoxide dismutase 1	Homo sapiens	35-38
11368166-6	2001	Such oxidations catalyzed by Cu,Zn SOD could account for the deleterious effects of the mutant Cu,Zn SODs associated with familial amyotrophic lateral sclerosis and of the overproduction or overadministration of wild-type Cu,Zn SOD.	Zinc	32-34	superoxide dismutase 1	Homo sapiens	101-104
11372199-1	2001	We postulate that zinc(II) is a keystone in the structure of physiological mouse copper metallothionein 1 (Cu-MT 1).	Zinc	18-26	metallothionein 1	Mus musculus	88-105
11306246-2	2001	Relevant amino acids were selected according to a peptidic binding site model for PDE4 inhibitors, which suggests interaction with two tryptophan residues, one histidine and one tyrosine residue, as well as one Zn(2+) ion.	Zinc	211-213	phosphodiesterase 4A	Homo sapiens	82-86
11264713-4	2001	This paper will also review studies from the authors" laboratory concerning the first attempts to map Zn in the respiratory epithelium and to elucidate its role in regulating caspase-3 activated apoptosis.	Zinc	102-104	caspase 3	Homo sapiens	175-184
11237855-7	2001	At pH 5.5, Nramp1(G169) (P=1.34x10(-13)) and NRAMP1 (P=1.09x10(-6)) oocytes showed significant efflux of Zn2+.	Zinc	105-109	solute carrier family 11 member 1	Homo sapiens	11-17
11565904-8	2001	Bj IV showed allosteric enzymatic behavior, with maximal activity at pH 8.2 and 35-45 degrees C. Full PLA2 activity required Ca2+ but was inhibited by Cu2+ and Zn2+, and by Cu2+ and Mg2+ in the presence and absence of Ca2+, respectively.	Zinc	160-164	phospholipase A2, group V	Mus musculus	102-106
11396782-1	2001	The altered plasma statuses of selected minerals (Ca, Mg, Cu, Zn) have been noted in a cluster of insulin resistance syndromes, including hypertension and diabetes mellitus.	Zinc	62-64	insulin	Homo sapiens	98-105
11237855-4	2001	We used Xenopus oocytes to demonstrate that, like Nramp2, Nramp1 is a bivalent cation (Fe2+, Zn2+ and Mn2+) transporter.	Zinc	93-97	solute carrier family 11 member 1	Homo sapiens	58-64
11237855-7	2001	At pH 5.5, Nramp1(G169) (P=1.34x10(-13)) and NRAMP1 (P=1.09x10(-6)) oocytes showed significant efflux of Zn2+.	Zinc	105-109	solute carrier family 11 member 1	Homo sapiens	45-51
10846076-6	2000	When expressed as a maltose binding protein (MBP) fusion protein by bacteria, the NS protease exhibited activity both in the bacteria and in vitro following purification when denatured and refolded in the presence of Zn.	Zinc	217-219	myelin basic protein	Homo sapiens	20-43
11293472-8	2001	CONCLUSIONS: IGF-I is commonly low in this population and is associated with low plasma amino acid and Zn concentrations, despite high intakes of these nutrients.	Zinc	103-105	insulin like growth factor 1	Homo sapiens	13-18
11168375-4	2001	The folding of rD5 seems to be modulated by the metal ions Zn2+, Ni2+, and Cu2+ as a specific antibody directed against the zinc-binding site in HK binds to HK and rD5 in a metal ion concentration dependent manner.	Zinc	59-63	defensin alpha 24	Rattus norvegicus	15-18
16233148-7	2001	The optimum temperature for MBP-fused GnT-I activity was 40 degrees C, but the enzyme was active between 0-70 degrees C. Mn2+ and Co2+ were critical for the enzyme activity, while Zn2+ and Ca2+ inhibited the activity.	Zinc	180-184	myelin basic protein	Homo sapiens	28-31
11175901-2	2001	The high resolution crystal structure of LTA4H in complex with the competitive inhibitor bestatin reveals a protein folded into three domains that together create a deep cleft harboring the catalytic Zn(2+) site.	Zinc	200-202	leukotriene A4 hydrolase	Homo sapiens	41-46
10846076-6	2000	When expressed as a maltose binding protein (MBP) fusion protein by bacteria, the NS protease exhibited activity both in the bacteria and in vitro following purification when denatured and refolded in the presence of Zn.	Zinc	217-219	myelin basic protein	Homo sapiens	45-48
10846076-8	2000	Expression of individual domains within the protease as MBP fusions and analysis by a Zn(65) binding assay revealed two Zn binding domains: one located at a predicted metal binding motif beginning at Cys1175 and the other one close to the cleavage site.	Zinc	120-122	myelin basic protein	Homo sapiens	56-59
10888679-5	2000	luv1 mutants are sensitive to several ions (Zn(2+), Mn(2+), and Cd(2+)) and to pH extremes.	Zinc	44-46	Vps54p	Saccharomyces cerevisiae S288C	0-4
10890158-2	2000	[ZnII(DPAS)Cl] promoted hydrolysis of sodium bis(p-nitrophenyl)hydrogenphosphate), BNP-.	Zinc	1-5	natriuretic peptide B	Homo sapiens	83-86
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	27-29	replication protein A2	Homo sapiens	267-272
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	166-168	replication protein A2	Homo sapiens	267-272
10788456-0	2000	Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex.	Zinc	0-4	oxoglutarate dehydrogenase	Rattus norvegicus	88-121
10788456-9	2000	Purified pig heart alpha-ketoglutarate dehydrogenase complex was strongly inhibited by Zn(2+) (K(i)(app) = 0.37 +/- 0.05 micrometer).	Zinc	87-91	oxoglutarate dehydrogenase	Rattus norvegicus	19-52
10788456-13	2000	Physiological free Zn(2+) may modulate hepatic mitochondrial respiration by reversible inhibition of the alpha-ketoglutarate dehydrogenase complex.	Zinc	19-21	oxoglutarate dehydrogenase	Rattus norvegicus	105-138
10785382-2	2000	Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2).	Zinc	83-85	thyrotropin releasing hormone	Homo sapiens	0-29
10785382-2	2000	Thyrotropin-releasing hormone-degrading ectoenzyme is a member of the M1 family of Zn-dependent aminopeptidases and catalyzes the degradation of thyrotropin-releasing hormone (TRH; Glp-His-Pro-NH2).	Zinc	83-85	thyrotropin releasing hormone	Homo sapiens	145-174
10830874-2	2000	Based on stability constants determined by potentiometric pH titrations in aqueous solution, it is shown that the M(AcP) complexes of Ca2+, Mg2+, Mn2+, Cu2+, and Zn2+ are more stable than is expected from the basicity of the phosphate group of AcP2-.	Zinc	162-166	acid phosphatase 2, lysosomal	Homo sapiens	244-248
10657263-1	2000	In serum-starved NIH 3T3 fibroblasts, ethanol (30-80 mM) promoted the effects of insulin and insulin-like growth factor I (IGF-I) on DNA synthesis in a Zn(2+)-dependent manner.	Zinc	152-154	insulin-like growth factor 1	Mus musculus	93-121
10657263-1	2000	In serum-starved NIH 3T3 fibroblasts, ethanol (30-80 mM) promoted the effects of insulin and insulin-like growth factor I (IGF-I) on DNA synthesis in a Zn(2+)-dependent manner.	Zinc	152-154	insulin-like growth factor 1	Mus musculus	123-128
10657263-6	2000	In contrast, ethanol inhibited insulin-induced activating phosphorylation of p42/p44 mitogen-activated protein kinases; these inhibitory ethanol effects were prevented by Zn(2+).	Zinc	171-173	cyclin-dependent kinase 20	Mus musculus	77-80
12651475-3	2000	Soil solution Ca additions increased foliar Ca and Zn concentrations, and increased rates of respiration early in the growing season (July).	Zinc	51-53	radial spoke head 1 homolog (Chlamydomonas)	Mus musculus	14-16
12651475-8	2000	Leaching losses of Ca were more than twice those of the element with the next highest amount of leaching (Zn), and probably led to the reductions in mCa concentration and membrane stability of acid-treated saplings.	Zinc	106-108	radial spoke head 1 homolog (Chlamydomonas)	Mus musculus	19-21
10571075-6	1999	Due to the fact that the inhibitory effect of Zn2+ was present at physiological serum concentrations, it is assumed that released S100A8/A9 may carry AA at inflammatory lesions, but not within the blood compartment.	Zinc	46-50	S100 calcium binding protein A8	Homo sapiens	130-136
10497274-11	1999	Among known DNase inhibitors tested, aurintricarboxylic acid and Zn(2+)are found to be effective inhibitors of the DLAD activity.	Zinc	65-71	deoxyribonuclease 2 beta	Homo sapiens	115-119
10550637-0	1999	Susceptibility of the guard-cell K(+)-uptake channel KST1 to Zn(2+) requires histidine residues in the S3-S4 linker and in the channel pore Potassium channels are inhibited by several mono- and divalent cations.	Zinc	61-63	Potassium channel KAT1-like	Solanum tuberosum	53-57
10550637-5	1999	Whereas substitution of the pore histidine H271 resulted in a reduced blockade by Zn(2+), the channel mutant KST1-H160A in the S3-S4 linker lost most of its Zn(2+ )sensitivity.	Zinc	157-159	Potassium channel KAT1-like	Solanum tuberosum	109-113
10550637-6	1999	Since both histidines alter the susceptibility of KST1 to Zn(2+), the block may predominantly result from these two sites.	Zinc	58-60	Potassium channel KAT1-like	Solanum tuberosum	50-54
10346818-4	1999	By replacing the carboxy-terminal TRAF domain of TRAF2 and TRAF6 with repeats of the immunophilin FKBP12, we demonstrate that their effector domains are composed of their amino-terminal Zn and RING fingers.	Zinc	186-188	FKBP prolyl isomerase 1A	Homo sapiens	85-104
10216093-7	1999	Moreover, Zn2+ enhanced leukocytic cell adhesion to FBG and endothelial cell monolayers by activating beta2-integrins.	Zinc	10-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-107
10322050-2	1999	The modulation by Cu2+ and Zn2+ of P2X2 and P2X4 receptors expressed in Xenopus oocytes was studied with the two-electrode, voltage-clamp technique.	Zinc	27-31	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	35-39
10322050-3	1999	In oocytes expressing P2X2 receptors, both Cu2+ and Zn2+, in the concentration range 1-130 microM, reversibly potentiated current activated by submaximal concentrations of ATP.	Zinc	52-56	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	22-26
10322050-7	1999	However, Cu2+ did not enhance ATP-activated current in the presence of a maximally effective concentration of Zn2+, suggesting a common site or mechanism of action of Cu2+ and Zn2+ on P2X2 receptors.	Zinc	176-180	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	184-188
10322050-11	1999	The results suggest that Cu2+ and Zn2+ differentially modulate the function of P2X2 and P2X4 receptors, perhaps because of differences in a shared site of action on both subunits or the absence of a site for Cu2+ action on the P2X4 receptor.	Zinc	34-38	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	79-83
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	16-20
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	166-170
10402203-3	1999	Here, we show that two neighboring histidine residues on NR2A represent the critical determinant (termed the "short spacer") for high-affinity, voltage-independent Zn2+ inhibition using the Xenopus oocyte expression system and site-directed mutagenesis.	Zinc	164-168	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	57-61
10402203-4	1999	Mutation of either one of these two histidine residues (H42 and H44) in the extracellular N-terminal domain of NR2A shifted the IC50 for high-affinity Zn2+ inhibition approximately 200-fold without affecting the EC50 of the coagonists NMDA and glycine.	Zinc	151-155	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	111-115
11842894-8	2001	PF and Zn- rats repleted 2 days with diets devoid of protein had highest GRF secretion (P&lt;0.01) compared to other groups.	Zinc	7-9	growth hormone releasing hormone	Rattus norvegicus	73-76
11842895-8	2001	All Zn- and Zn+ rats administered anti-GRF IgG exhibited a reduction in protein intake during zinc repletion.	Zinc	4-6	growth hormone releasing hormone	Rattus norvegicus	39-42
11842895-8	2001	All Zn- and Zn+ rats administered anti-GRF IgG exhibited a reduction in protein intake during zinc repletion.	Zinc	12-14	growth hormone releasing hormone	Rattus norvegicus	39-42
10816735-1	1999	Previous in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner.	Zinc	50-54	thyrotropin releasing hormone	Homo sapiens	101-130
11302204-1	2001	The binuclear zinc(II) complex, [Zn2(HPTP)(CH3COO)]2+ was found highly active to cleave DNA (double-strand super-coiled DNA, pBR322 and phix174) in the presence of hydrogen peroxide.	Zinc	14-22	protein tyrosine phosphatase receptor type D	Homo sapiens	37-41
10574817-9	1999	Although the in vitro activity of MMP-2 was inhibited by both Cu(2+) and Zn(2+), Cu(2+) apparently induced the keratocytes to produce activated enzyme and Zn(2+) irreversibly inhibited their production of MMP-2.	Zinc	73-75	matrix metallopeptidase 2	Homo sapiens	34-39
11123935-6	2000	The guanylyl cyclase activity of GCC-IDbac was inhibited by Zn(2+), at concentrations shown to inhibit adenylyl cyclase, suggesting a structural homology between the two enzymes.	Zinc	60-62	guanylate cyclase 2C	Homo sapiens	33-36
10574817-9	1999	Although the in vitro activity of MMP-2 was inhibited by both Cu(2+) and Zn(2+), Cu(2+) apparently induced the keratocytes to produce activated enzyme and Zn(2+) irreversibly inhibited their production of MMP-2.	Zinc	155-157	matrix metallopeptidase 2	Homo sapiens	34-39
10190043-0	1999	Inhibition kinetics of human serum butyrylcholinesterase by Cd2+, Zn2+ and Al3+: comparison of the effects of metal ions on cholinesterases.	Zinc	66-70	cholinesterase	Ovis aries	35-56
10190043-9	1999	But when the enzyme was inhibited by 0.5 mM Cd2+ or Zn2+, Ca2+ and Mg2+ partially reactivated the inhibited allosteric form of BChE.	Zinc	52-56	cholinesterase	Ovis aries	127-131
10574817-12	1999	Zn(2+) on the other hand inhibited both MMP-2 production and MMP-2 activity and may, therefore, be of therapeutic value if suitably formulated and used in conjunction with systemic steroid treatment.	Zinc	0-2	matrix metallopeptidase 2	Homo sapiens	40-45
11056018-3	2000	DNA binding of MTF-1 is known to be stimulated by Zn in vitro, but the binding was also largely influenced by redox conditions, suggesting that redox signals could modulate MTF-1 activity.	Zinc	50-52	metal regulatory transcription factor 1	Homo sapiens	15-20
10574817-12	1999	Zn(2+) on the other hand inhibited both MMP-2 production and MMP-2 activity and may, therefore, be of therapeutic value if suitably formulated and used in conjunction with systemic steroid treatment.	Zinc	0-2	matrix metallopeptidase 2	Homo sapiens	61-66
11056018-3	2000	DNA binding of MTF-1 is known to be stimulated by Zn in vitro, but the binding was also largely influenced by redox conditions, suggesting that redox signals could modulate MTF-1 activity.	Zinc	50-52	metal regulatory transcription factor 1	Homo sapiens	173-178
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Zinc	36-38	arginase 1	Rattus norvegicus	231-236
10025571-1	1999	We have previously provided evidence that two transition metal cations, Zn2+ and Cu2+, can alter the conformation of nerve growth factor (NGF), rendering it unable to bind to its receptors or to activate signal transduction pathways.	Zinc	72-76	nerve growth factor	Rattus norvegicus	117-136
10025571-1	1999	We have previously provided evidence that two transition metal cations, Zn2+ and Cu2+, can alter the conformation of nerve growth factor (NGF), rendering it unable to bind to its receptors or to activate signal transduction pathways.	Zinc	72-76	nerve growth factor	Rattus norvegicus	138-141
10025571-2	1999	In the present study, we have assessed the influence of Zn2+ and Cu2+ on NGF-mediated protection from an oxidative insult.	Zinc	56-60	nerve growth factor	Rattus norvegicus	73-76
10220355-4	1999	In this paper, we report that several divalent metal cations, such as Mn2+, Co2+, Ni2+, and Zn2+ bind to the second Mg2+-binding site of Csk with up to 13200-fold higher affinity than Mg2+.	Zinc	92-96	C-terminal Src kinase	Homo sapiens	137-140
10025571-4	1999	Zn2+ and Cu2+, when added to cultures at a concentration of 100 microM, prevented NGF-mediated survival-promoting effects.	Zinc	0-4	nerve growth factor	Rattus norvegicus	82-85
10025571-6	1999	These results demonstrate that Zn2+ and Cu2+ can selectively inhibit NGF-mediated resistance to an oxidative stress, and have significant implications for neuronal function under both physiological and pathological (e.g. cerebral ischemia) conditions.	Zinc	31-35	nerve growth factor	Rattus norvegicus	69-72
9886489-13	1999	After stable transfection with human NHE-1 in a vector utilizing the metallothionein promoter, overnight induction with Zn(2+)increased the NHE activity and its sensitivity to amiloride only in the basolateral membrane in OK7a cells.	Zinc	120-122	solute carrier family 9 member C1	Homo sapiens	37-40
10956668-5	2000	Although the binding of TSP-4 to solid-phase collagens was enhanced by Zn(2+), that to non-collagenous proteins was not.	Zinc	71-73	thrombospondin 4	Homo sapiens	24-29
11027581-5	2000	Since the His and Asp residues are both responsible for binding Zn which would serve to maintain the folded structure, the structural integrity supported by the coordinated Zn ion would be essential for CCS function.	Zinc	173-175	copper chaperone for superoxide dismutase	Homo sapiens	203-206
10220355-8	1999	Zn2+ has the highest affinity for the second Mg2+-binding site of Csk at 0.65 microM, but supports no kinase activity, acting as a dead-end inhibitor.	Zinc	0-4	C-terminal Src kinase	Homo sapiens	66-69
10882717-3	2000	Here we characterized the human recombinant S100A5, especially its interaction with Ca(2+), Zn(2+), and Cu(2+).	Zinc	92-94	S100 calcium binding protein A5	Homo sapiens	44-50
10882717-5	2000	S100A5 also binds two Zn(2+) ions and four Cu(2+) ions per dimer.	Zinc	22-24	S100 calcium binding protein A5	Homo sapiens	0-6
10477985-5	1999	Zn, even at concentrations as low as 0.1 mM/L, inhibited the crystal growth of DCPD, OCP and AP; and, at higher concentrations (0.5 mM to 2 mM/L), promoted the formation of amorphous calcium phosphate, ACP, or Zn-substituted tricalcium phosphate (beta-TCP) depending on the reaction pH and temperature.	Zinc	0-2	CPAT1	Homo sapiens	202-205
11670819-20	1998	On the basis of the above findings, a mechanistic scheme for the TNP hydrolysis by 2 is proposed; a TNP molecule is bound to the Pb center, and the hydroxide on the adjacent Zn ion attacks the phosphorus nucleus of TNP, leading to the formation of the BNP complex 3.	Zinc	174-176	natriuretic peptide B	Homo sapiens	252-255
10082765-9	1999	There was a significant negative correlation between T lymphocyte p56(lck) expression and serum Zn (r= -0.65, P = 0.0007) or femur Zn (r = -0.73, P = 0.0001) concentrations.	Zinc	96-98	interferon-induced protein with tetratricopeptide repeats 1	Mus musculus	66-69
10082765-9	1999	There was a significant negative correlation between T lymphocyte p56(lck) expression and serum Zn (r= -0.65, P = 0.0007) or femur Zn (r = -0.73, P = 0.0001) concentrations.	Zinc	96-98	lymphocyte protein tyrosine kinase	Mus musculus	70-73
11051593-5	2000	NPY-treated mice that were given Zn and L-NAME cotreatments had compatible results of determined variables in comparison with control mice.	Zinc	33-35	neuropeptide Y	Mus musculus	0-3
10082765-9	1999	There was a significant negative correlation between T lymphocyte p56(lck) expression and serum Zn (r= -0.65, P = 0.0007) or femur Zn (r = -0.73, P = 0.0001) concentrations.	Zinc	131-133	interferon-induced protein with tetratricopeptide repeats 1	Mus musculus	66-69
11051593-6	2000	This study showed that Zn and L-NAME attenuated NPY-mediated feeding and selected serum variables in mice.	Zinc	23-25	neuropeptide Y	Mus musculus	48-51
10082765-9	1999	There was a significant negative correlation between T lymphocyte p56(lck) expression and serum Zn (r= -0.65, P = 0.0007) or femur Zn (r = -0.73, P = 0.0001) concentrations.	Zinc	131-133	lymphocyte protein tyrosine kinase	Mus musculus	70-73
10609297-4	1999	The relative efficiency of the different cations in insuring of the ATP-dependent Ca2+ accumulation was Mg2+ &gt; Mn2+ = Co2+ &gt;&gt; Ni2+; the Ca2+ accumulation was not observed in the presence of 3 mM Zn2+ or Cu2+.	Zinc	204-208	mucin 7, secreted	Homo sapiens	104-107
10024455-5	1999	The active site of PTPS consists of the pterin-anchoring Glu A107 neighboured by two catalytic motifs: a Zn(II) binding site and an intersubunit catalytic triad formed by Cys A42, Asp B88 and His B89.	Zinc	105-111	6-pyruvoyltetrahydropterin synthase	Homo sapiens	19-23
10187914-7	1999	DNA-protein complex formation between the investigated rpL32 promoter fragment containing the GCC-element and human fibroblast nuclear proteins is Zn2+-dependent.	Zinc	147-151	guanylate cyclase 2C	Homo sapiens	94-97
9826943-10	1998	SSB generation by hydroxyl radicals formed by 137Cs-gamma rays in Zn-treated cells decreased by 12%, accompanied by a decrease in d from 4.8 nm to 2.9 nm.	Zinc	66-68	small RNA binding exonuclease protection factor La	Homo sapiens	0-3
11670523-7	1998	An analogous reaction was observed for the cadmium derivative, Cd-1, which displays a (1)H NMR spectrum identical to that of Zn-2.	Zinc	125-129	CD1c molecule	Homo sapiens	63-67
9559907-0	1998	Zn2+ modulation of ATP-responses at recombinant P2X2 receptors and its dependence on extracellular pH.	Zinc	0-4	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	48-52
9559907-8	1998	The potentiating effect of Zn2+ was progressively diminished by acidic shifts in extracellular pH (pHe) which, of itself, also potentiated ATP-responses at P2X2 receptors.	Zinc	27-31	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	156-160
9559907-14	1998	Zn2+ also enhanced the blocking activity of the P2 receptor antagonist suramin at P2X2 receptors.	Zinc	0-4	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	82-86
9559907-15	1998	Therefore, Zn2+ also mimics H+ in increasing suramin-activity at P2X2 receptors.	Zinc	11-15	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	65-69
9559907-17	1998	In summary, Zn2+ and H+ potentiate agonist and antagonist activity at P2X2 receptors but their effects are not wholly alike for receptor agonism.	Zinc	12-16	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	70-74
9848163-6	1998	Cations of Pb, Cd or Zn introduced to the incubation medium instead of Mg2+ (5 mM) also stimulate both superprecipitation and ATPase activity but the level of the both processes decreases by 65%, 20% and 5%, respectively, as compared to control (i.e. in presence of Mg2+).	Zinc	21-23	dynein axonemal heavy chain 8	Homo sapiens	126-132
9514197-7	1998	After intracellular alkalinization imposed by an acetate prepulse, pHi recovery was unaffected by DIDS but was significantly reduced in the absence of extracellular Cl-, as well as in the presence of Zn2+, which is a blocker of proton channels.	Zinc	200-204	glucose-6-phosphate isomerase 1	Mus musculus	67-70
9452440-4	1998	By using a new method based on interactions of GroEL with octyl-Sepharose, it was demonstrated that Zn2+ binding strengthens GroEL hydrophobic binding interactions and increases the efficiency of substrate release upon the addition of MgATP and GroES.	Zinc	100-104	heat shock protein family E (Hsp10) member 1	Homo sapiens	245-250
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	Zinc	174-178	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	46-50
9498326-2	1998	We hypothesize that the mutation affects the cell Zn content, which subsequently affects the activity of various zinc-dependent enzymes, such as 5"-nucleotidase.	Zinc	50-52	5'-nucleotidase ecto	Homo sapiens	145-160
9498326-5	1998	The activity of 5"-nucleotidase in the AE fibroblasts grown in 16 micromol/L Zn or 1.5 micromol/L Zn medium was also significantly lower than in normal fibroblasts.	Zinc	77-79	5'-nucleotidase ecto	Homo sapiens	16-31
9498326-7	1998	Cells grown in 200 micromol/L Zn medium exhibited threefold greater 5"-nucleotidase activity in AE fibroblasts, but had no affect on enzyme activity in normal cells.	Zinc	30-32	5'-nucleotidase ecto	Homo sapiens	68-83
9498326-11	1998	The lower cell Zn content subsequently affects the activity of 5"-nucleotidase.	Zinc	15-17	5'-nucleotidase ecto	Homo sapiens	63-78
9607116-2	1998	Recent evidence suggests that the gC1qR also serves as the Zn(++)-dependent endothelial cell binding site for factor XII and high-molecular-weight kininogen, and activates intrinsic coagulation and kinin pathways in purified systems.	Zinc	59-65	complement C1q binding protein	Homo sapiens	34-39
9221770-3	1997	The comparison of NR1a-NR2A and NR1a-NR2B receptors shows that the voltage-dependent inhibition is similar in both types of receptors but that the voltage-independent inhibition occurs at much lower Zn2+ concentrations in NR1a-NR2A receptors (IC50 in the nanomolar range) than in NR1a-NR2B receptors (IC50 in the micromolar range).	Zinc	199-203	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	37-41
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	93-97
11007174-3	2000	Manipulating the Zn concentration in the low microM range reversibly modulates the DNA-binding activity of the mammalian MTF-1; this effect is inhibited at low temperature.	Zinc	17-19	metal regulatory transcription factor 1	Homo sapiens	121-126
9221770-5	1997	By analyzing the effects of Zn2+ on varied combinations of NR1 (NR1a or NR1b) and NR2 (NR2A, NR2B, NR2C), we show that both the NR1 and the NR2 subunits contribute to the voltage-independent Zn2+ inhibition.	Zinc	28-32	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	99-103
11007174-6	2000	MTF-1-binding from the cells of both species of fish was activated when cells were treated with Zn but not with Cd.	Zinc	96-98	metal regulatory transcription factor 1	Homo sapiens	0-5
11007174-10	2000	Similarly, Zn reversibly modulated MTF-1L binding, but, in contrast, such modulation occurred readily at 4 degrees C. This data demonstrate the conservation of binding specificity, binding properties, and regulation of MTF-1 in fishes.	Zinc	11-13	metal regulatory transcription factor 1	Homo sapiens	35-40
9256278-4	1997	Molecular modeling studies predict that Zn2+ binding to NGF will induce structural changes within domains of this neurotrophin that participate in the recognition of TrkA and p75NTR.	Zinc	40-44	neurotrophic receptor tyrosine kinase 1	Homo sapiens	166-170
9228015-5	1997	Using a cell-free system consisting of purified bovine PARP as a substrate and an apoptotic extract or recombinant caspase-3 as the PARP protease, Zn2+ inhibited PARP proteolysis in the low micromolar range.	Zinc	147-151	caspase 3	Bos taurus	115-124
9232632-4	1997	The order of defibrillization of A beta 1-40 fibrils by metal cations was: Ca2+ and Zn2+ (IC50 = 100 microM) > Mg3+ (IC50 = 300 microM) > Al3+ (IC50 = 1.1 mM).	Zinc	84-88	AA1	Homo sapiens	33-41
10799481-1	2000	Cu(2+) and Zn(2+) inhibit all of the NADPH-dependent reactions catalyzed by neuronal nitric-oxide synthase (nNOS) including ferricytochrome c reduction, NADPH oxidation, and citrulline formation.	Zinc	11-17	nitric oxide synthase 1	Homo sapiens	76-106
10799481-1	2000	Cu(2+) and Zn(2+) inhibit all of the NADPH-dependent reactions catalyzed by neuronal nitric-oxide synthase (nNOS) including ferricytochrome c reduction, NADPH oxidation, and citrulline formation.	Zinc	11-17	nitric oxide synthase 1	Homo sapiens	108-112
10799481-3	2000	Zn(2+) affects all activities of the full-length nNOS and the reductase domain to the same extent (estimated IC(50) values from 9 to 31 microm), suggesting Zn(2+) occupation of a single site in the reductase domain.	Zinc	0-2	nitric oxide synthase 1	Homo sapiens	49-53
10799481-3	2000	Zn(2+) affects all activities of the full-length nNOS and the reductase domain to the same extent (estimated IC(50) values from 9 to 31 microm), suggesting Zn(2+) occupation of a single site in the reductase domain.	Zinc	156-158	nitric oxide synthase 1	Homo sapiens	49-53
10799481-6	2000	These data suggest the possibility that Cu(2+) may interact with nNOS at two sites, one composed exclusively of the reductase domain (which is perhaps also involved in Zn(2+)-mediated inhibition), and another that includes components of both domains.	Zinc	168-174	nitric oxide synthase 1	Homo sapiens	65-69
9852106-6	1998	The steady state pool of Drs2p, which was shown to reside predominantly in the plasma membrane, increased upon shift to low temperature or exposure to various divalent cations (Mn2+, Co2+, Ni2+, and Zn2+ but not Ca2+ or Mg2+), conditions that also inhibited the growth of a drs2 null mutant.	Zinc	199-203	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	25-30
9016352-6	1997	Low extracellular Zn2+ concentrations (5-10 microM) increase the apparent gating efficiency of human P2X4 by ATP without affecting the maximal response.	Zinc	18-22	purinergic receptor P2X 4	Homo sapiens	101-105
9830036-4	1998	In an in vitro binding reaction, Zn2+ mediates p56(lck) association with a glutathione S-transferase (GST) fusion protein containing the cytosolic domains of CD4 or CD8alpha; no other metals tested support binding.	Zinc	33-37	cyclin dependent kinase like 2	Homo sapiens	47-50
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	cyclin dependent kinase like 2	Homo sapiens	31-34
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	cyclin dependent kinase like 2	Homo sapiens	171-174
10788426-2	2000	In addition to Ca(2+), several members of the S100 protein family, including S100A2, bind Zn(2+).	Zinc	90-92	S100 calcium binding protein A2	Homo sapiens	77-83
10788426-4	2000	Human S100A2 contains four cysteine residues, each of them located at positions that may be important for Zn(2+) binding.	Zinc	106-112	S100 calcium binding protein A2	Homo sapiens	6-12
10788426-6	2000	Here we show that Cys(1(3)) (the number in parentheses indicating the position in the sequence of S100A2) is the crucial determinant for Zn(2+) binding in association with conformational changes as determined by internal tyrosine fluorescence.	Zinc	137-139	S100 calcium binding protein A2	Homo sapiens	98-104
8841119-5	1996	Non-template-directed nucleotidyl transfer is also observed when pol beta-DNA cocrystals are soaked in the presence of dATP and Zn2+, but the reaction products differ in that the sugar moiety of the incorporated nucleotide appears distorted or otherwise cleaved, in agreement with reports that Zn2+ may act as a polymerase inhibitor rather than as a mutagen [Sirover, M. A., &amp; Loeb, L. A.	Zinc	128-132	DNA polymerase beta	Homo sapiens	65-73
10832070-7	2000	After 24 h in culture, the level of activated AP-1 was markedly higher in the 0.5 and 5 microM Zn cells than in the control (72 and 58%, respectively) and 50 microM Zn cells (73 and 60%, respectively).	Zinc	95-97	jun proto-oncogene	Mus musculus	46-50
10832070-7	2000	After 24 h in culture, the level of activated AP-1 was markedly higher in the 0.5 and 5 microM Zn cells than in the control (72 and 58%, respectively) and 50 microM Zn cells (73 and 60%, respectively).	Zinc	165-167	jun proto-oncogene	Mus musculus	46-50
11203530-3	2000	The aim of this work was to test the effect of Zn, Cu, Sn and Hg ions on the activity of the major gingival gelatinolytic MMPs.	Zinc	47-49	matrix metallopeptidase 2	Homo sapiens	122-126
9836590-11	1998	The results revealed that Zn2+ specifically coordinates to the His1 and Asp3 residues of each secretin monomer without disrupting the peptide"s helical structure, whereas Ca2+ did not exhibit any interaction with the peptide hormone.	Zinc	26-30	viral integration site 1	Homo sapiens	63-67
9822722-8	1998	This conclusion is supported by data showing that divalent cations such as Cd2+ and Zn2+ (50-200 microM) slowed closed-state inactivation and also dramatically increased the ramp currents for DRG TTX-S currents and hNE channels but not for hSkM1 channels.	Zinc	84-88	elastase, neutrophil expressed	Homo sapiens	215-218
8841119-5	1996	Non-template-directed nucleotidyl transfer is also observed when pol beta-DNA cocrystals are soaked in the presence of dATP and Zn2+, but the reaction products differ in that the sugar moiety of the incorporated nucleotide appears distorted or otherwise cleaved, in agreement with reports that Zn2+ may act as a polymerase inhibitor rather than as a mutagen [Sirover, M. A., &amp; Loeb, L. A.	Zinc	294-298	DNA polymerase beta	Homo sapiens	65-73
8880741-2	1996	Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors.	Zinc	0-4	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	77-81
9930410-0	1998	Lysophosphatidylcholine acyltransferase activity in Saccharomyces cerevisiae: regulation by a high-affinity Zn2+ binding site.	Zinc	108-112	lysophosphatidylcholine acyltransferase	Saccharomyces cerevisiae S288C	0-39
9620874-8	1998	The mature form of recombinant DNase gamma, from which the N-terminal precursor has been removed, has the same properties as purified DNase gamma: requirement for divalent cations, dependence on pH, sensitivity to Zn2+, and cleavage of chromosome DNA to nucleosomal units.	Zinc	214-218	deoxyribonuclease 1-like 3	Rattus norvegicus	31-42
9679326-5	1998	The DNA hydrolytic activity associated with tissue TGase was dependent on Mg2+ in contrast to the Ca2+ requirement for the classical cross-linking activity of TGase, and was inhibited by Zn2+.	Zinc	187-191	transglutaminase 1	Homo sapiens	51-56
9679326-5	1998	The DNA hydrolytic activity associated with tissue TGase was dependent on Mg2+ in contrast to the Ca2+ requirement for the classical cross-linking activity of TGase, and was inhibited by Zn2+.	Zinc	187-191	transglutaminase 1	Homo sapiens	159-164
18475857-0	1998	Studies on Some Biologically Cobalt(II), Copper(II) and Zinc(II) Complexes With ONO, NNO and SNO Donor Pyrazinoylhydrazine-Derived Ligands.	Zinc	56-64	strawberry notch homolog 1	Homo sapiens	93-96
18475857-1	1998	Biologically active complexes of Co(II), Ni(II), Cu(II) and Zn(II) with novel ONO, NNO and SNO donor pyrazinoylhydrazine-derived compounds have been prepared and characterized on the basis of analytical data and various physicochemical studies.	Zinc	60-66	strawberry notch homolog 1	Homo sapiens	91-94
9448095-7	1997	Human liver HMW-ZnAP requires Zn2+-ions for activity; other divalent cations are ineffective or act as inhibitors.	Zinc	30-34	cilia and flagella associated protein 97	Homo sapiens	12-15
9245697-6	1997	Specific angiogenin binding to the lower affinity matrix sites was increased by 2.7- and 1.9-fold in the presence of Cu2+ and Zn2+ respectively.	Zinc	126-130	angiogenin	Homo sapiens	9-19
9054574-8	1997	Additional positive charges in the active site of CA IV stabilize anions as indicated by a decreased pKa for the Zn-bound water compared to CA II (6.2 vs 6.9), as well as lower inhibition constants for a variety of anions, including halides, sulfate, formate, acetate, and bicarbonate.	Zinc	113-115	carbonic anhydrase 4	Homo sapiens	50-55
9483901-2	1997	Zn and Cu content of the soil exceeds the background levels and approaches the MACs.	Zinc	0-2	myristoylated alanine rich protein kinase C substrate	Homo sapiens	79-83
10698970-6	2000	Inhibition of phosphorylation by Zn(2+) suggests a possible control of 43K rapsyn phosphorylation state by its zinc finger domain.	Zinc	33-35	receptor associated protein of the synapse	Homo sapiens	75-81
10824681-9	2000	GABA(C) receptors were more susceptible to Zn2+; the IC50 for the GABA(A) receptor was 67.4 microM and that for the GABA(C) receptor was 1.9 microM.	Zinc	43-47	gamma-aminobutyric acid (GABA) C receptor, subunit rho 2	Mus musculus	0-16
10824681-10	2000	These results suggest that Zn2+ modulates the inhibitory interaction between amacrine and bipolar cells, particularly that mediated by the GABA(C) receptor.	Zinc	27-31	gamma-aminobutyric acid (GABA) C receptor, subunit rho 2	Mus musculus	139-155
10551873-1	1999	Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs.	Zinc	101-107	matrix metallopeptidase 2	Homo sapiens	46-50
10551873-1	1999	Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs.	Zinc	101-107	matrix metallopeptidase 2	Homo sapiens	130-134
10551873-9	1999	MT4-MMP is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A.	Zinc	35-37	matrix metallopeptidase 2	Homo sapiens	163-178
10542287-6	1999	Zn(2+) induced a sustained increase in phosphorylation of the alpha subunit of the translation eukaryotic initiation factor-2 (eIF-2alpha), whereas it triggered a transient increase in phosphorylation of eukaryotic elongation factor-2 (eEF-2).	Zinc	0-2	eukaryotic translation initiation factor 2A	Mus musculus	127-137
10542287-9	1999	These results suggest that Zn(2+)-induced inhibition of protein synthesis mainly correlates with the increase in eIF-2alpha phosphorylation.	Zinc	27-33	eukaryotic translation initiation factor 2A	Mus musculus	113-123
10510462-0	1999	Modulatory activity of extracellular H+ and Zn2+ on ATP-responses at rP2X1 and rP2X3 receptors.	Zinc	44-48	purinergic receptor P2X 1	Rattus norvegicus	69-74
10510462-1	1999	1 The modulatory activity of extracellular H+ and Zn2+ was examined on ATP-responses at rat P2X1 (rP2X1) and rat P2X3 (rP2X3) receptors expressed in Xenopus oocytes and studied under voltage-clamp conditions.	Zinc	50-54	purinergic receptor P2X 1	Rattus norvegicus	92-96
10510462-1	1999	1 The modulatory activity of extracellular H+ and Zn2+ was examined on ATP-responses at rat P2X1 (rP2X1) and rat P2X3 (rP2X3) receptors expressed in Xenopus oocytes and studied under voltage-clamp conditions.	Zinc	50-54	purinergic receptor P2X 1	Rattus norvegicus	98-103
10510462-8	1999	4 Extracellular Zn2+ inhibited ATP-responses at rP2X1 receptors in a time-dependent manner, a 20 min pre-incubation being optimal (IC50 value, 1.0+/-0.2 microM).	Zinc	16-20	purinergic receptor P2X 1	Rattus norvegicus	48-53
10510462-12	1999	6 In summary, ATP activity at rP2X1 receptors was decreased by both extracellular H+ and Zn2+ and their effects were additive.	Zinc	89-93	purinergic receptor P2X 1	Rattus norvegicus	30-35
10438633-8	1999	The results show that Zn(II) is essential for the maintenance of the native structure of glyoxalase II and that its binding to the apoenzyme occurs during an essential step of refolding.	Zinc	22-28	hydroxyacylglutathione hydrolase	Homo sapiens	89-102
10499288-5	1999	Moreover, it is interesting to note that the Zn/HL2 complex exhibits specific cytotoxic activity against Pam-ras cells (cis-DDP resistant cells which over-express the H-ras oncogene) with an in vitro therapeutic index of 3.26 versus 0.78 for cis-DDP.	Zinc	45-47	peptidylglycine alpha-amidating monooxygenase	Mus musculus	105-108
8880741-4	1996	In contrast, the Zn2+ concentration-inhibition curve at NR1/NR2A receptors was biphasic, with high (Ki = 0.08 microM) and low (Ki = 30 microM) affinity components.	Zinc	17-21	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	60-64
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	72-76
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	154-158
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	131-135	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	154-158
8880741-7	1996	The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+.	Zinc	30-34	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	53-57
8880741-7	1996	The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+.	Zinc	143-147	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	53-57
8880741-8	1996	Differential effects of Zn2+ at recombinant NMDA receptors containing different NR2 subunits provide a potential marker for distinguishing subtypes of native NMDA receptors and for dissecting the site and mechanism of action of Zn2+ at these receptors.	Zinc	24-28	nodal homolog 2 L homeolog	Xenopus laevis	80-83
8880741-8	1996	Differential effects of Zn2+ at recombinant NMDA receptors containing different NR2 subunits provide a potential marker for distinguishing subtypes of native NMDA receptors and for dissecting the site and mechanism of action of Zn2+ at these receptors.	Zinc	228-232	nodal homolog 2 L homeolog	Xenopus laevis	80-83
8706705-3	1996	Zinc ions stimulated the ADP-ribosyl cyclase activity of MBP-CD38, but inversely inhibited its NAD+ glycohydrolase activity which was approximately 100-fold dominant to the cyclase activity in the absence of Zn2+.	Zinc	208-212	myelin basic protein	Homo sapiens	57-60
8706705-7	1996	The fluorescence increase was further enhanced by the addition of Zn2+ with a shift in the maximum emission wavelength from 484 nm to 470 nm, suggesting that Zn2+ caused conformational changes of MBP-CD38.	Zinc	66-70	myelin basic protein	Homo sapiens	196-199
8706705-7	1996	The fluorescence increase was further enhanced by the addition of Zn2+ with a shift in the maximum emission wavelength from 484 nm to 470 nm, suggesting that Zn2+ caused conformational changes of MBP-CD38.	Zinc	158-162	myelin basic protein	Homo sapiens	196-199
8632476-3	1996	Further fine-mapping using deletion and point mutation analysis shows that the DNA- and Zn-binding domains involve separate peptide motifs, KRRKTTPKEPTEKK (codons 202 to 215) for a bipartite DNA-binding oligopeptide (DB1) and CX2CX13HX2D(X)23EX2EX13CX3H (codons 232 to 297) for possibly two contiguous Zn-binding domains (AZn), which can function independently.	Zinc	88-90	vascular endothelial zinc finger 1	Homo sapiens	217-220
10452080-9	1998	CONCLUSION: Supplementation of Zn by diet rapidly raises the levels of Zn in serum, burn skin and growth hormone.	Zinc	31-33	gonadotropin releasing hormone receptor	Rattus norvegicus	98-112
9712865-4	1998	In addition, crystal structures of Zn-DtxR were determined in the same two space groups.	Zinc	35-37	MarR family transcriptional regulator	Corynebacterium diphtheriae	38-42
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	265-269
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	350-354
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	265-269
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	350-354
9668057-0	1998	Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins.	Zinc	20-24	S100 calcium binding protein A2	Homo sapiens	42-48
9668057-10	1998	Fluorescence enhancement of 4,4"-dianilino-1, 1"-binaphthyl-5,5"-disulfonic acid clearly indicated that Ca2+ and Zn2+ binding induce a hydrophobic patch at the surface of wtS100A2, which, as in calmodulin, may be instrumental for the regulatory role of S100A2 in the nucleus.	Zinc	113-117	S100 calcium binding protein A2	Homo sapiens	173-179
9533707-8	1998	In contrast to alkaline earth metal cations (Mg2+ and Ca2+), different binding behaviors were observed for the transition metal cations (Zn2+ and Cu2+).	Zinc	137-141	mucin 7, secreted	Homo sapiens	45-48
9523313-7	1998	Due to its additional high binding affinity towards bivalent metal ions, it also inhibited the Zn(2+)-dependent exopeptidases carboxypeptidase A, B and aminopeptidase N.	Zinc	95-101	alanyl aminopeptidase, membrane	Homo sapiens	152-168
9469942-7	1998	ADAM 20, but not 21, encodes a consensus Zn2+ binding site of active adamalysin metzincin metalloproteases, and both 20 and 21 encode putative cell-fusion peptides, required for sperm-egg fusion.	Zinc	41-45	ADAM metallopeptidase domain 20	Homo sapiens	0-7
9512239-4	1998	The results showed normal total zinc concentrations but very low HMW-Zn% values (P &lt; 0.001) in seminal plasma of the two groups of asthenozoospermic patients compared to the controls.	Zinc	69-71	cilia and flagella associated protein 97	Homo sapiens	65-68
9523453-8	1998	The Cd(2+)-resistance cation pump of Gram-positive bacteria is membrane P-type ATPase, which has been labeled with 32P from [gamma-32P]ATP and drives ATP-dependent Cd2+ (and Zn2+) transport by membrane vesicles.	Zinc	174-178	dynein axonemal heavy chain 8	Homo sapiens	79-85
9398237-3	1997	Human enamelysin (MMP-20) has a domain organization similar to other MMPs, including a signal peptide, a prodomain with the conserved motif PRCGVPD involved in maintaining enzyme latency, a catalytic domain with a Zn-binding site, and a COOH-terminal fragment similar to the sequence of hemopexin.	Zinc	214-216	matrix metallopeptidase 20	Homo sapiens	18-24
9405253-7	1997	Titrations of PDE4A inhibition with Mg2+ and Zn2+ as activating metal ions showed that the competitive inhibitors R-Rolipram, CDP-840, RS-14203 and KF18280 are shifted at least 10-fold to lower potency in the presence of Zn2+.	Zinc	45-49	cut like homeobox 1	Homo sapiens	126-129
9405253-7	1997	Titrations of PDE4A inhibition with Mg2+ and Zn2+ as activating metal ions showed that the competitive inhibitors R-Rolipram, CDP-840, RS-14203 and KF18280 are shifted at least 10-fold to lower potency in the presence of Zn2+.	Zinc	221-225	cut like homeobox 1	Homo sapiens	126-129
8954154-3	1996	This binding is enhanced by Zn2+ and is dependent on the concentration of parathymosin.	Zinc	28-32	parathymosin	Homo sapiens	74-86
8878561-4	1996	UV titrations confirm Tat peptide binds with two Zn2+ cations maximally per monomer, as previously reported(1).	Zinc	49-53	tyrosine aminotransferase	Homo sapiens	22-25
8858095-1	1996	Zn2+ has a paradoxical effect on IF1-ATPase interaction in cardiac muscle mitochondria in so-called slow heart-rate mammalian species like rabbit.	Zinc	0-4	dynein axonemal heavy chain 8	Homo sapiens	37-43
8858095-6	1996	While our earlier study suggested that there are two kinds of IF1-ATPase interaction, a docking interaction and an ATPase inhibitory interaction with Zn2+ promoting docking and interfering with inhibition, it did not yield information on whether Zn2+ interacted primarily with IF1, with the ATPase, or with both.	Zinc	150-154	dynein axonemal heavy chain 8	Homo sapiens	115-121
8858095-6	1996	While our earlier study suggested that there are two kinds of IF1-ATPase interaction, a docking interaction and an ATPase inhibitory interaction with Zn2+ promoting docking and interfering with inhibition, it did not yield information on whether Zn2+ interacted primarily with IF1, with the ATPase, or with both.	Zinc	150-154	dynein axonemal heavy chain 8	Homo sapiens	115-121
8858095-7	1996	In the present study we show that, in contrast to its effects in rabbit cardiomyocytes, mitochondria, and SMP in which Zn2+ fully blocked IF1-mediated ATPase inhibition, Zn2+ actually enhanced ATPase inhibition in rat cardiomyocytes, although the extent of this effect was limited by the low level of IF1 in rat cardiomyocytes.	Zinc	119-123	dynein axonemal heavy chain 8	Homo sapiens	151-157
8807898-2	1996	The artificial binding site in the resulting variant RBP/H3(A) has high affinity for Zn(II) and stabilizes the protein against denaturation.	Zinc	85-87	H3 clustered histone 1	Homo sapiens	57-62
8807898-3	1996	RESULTS: The metal-ion specificity of the grafted Zn(II) binding site in RBP/H3(A) was investigated.	Zinc	50-56	H3 clustered histone 1	Homo sapiens	77-82
8691507-9	1996	Zn pretreatment markedly reduced the activation of c-myc expression by Cd compared to cells not receiving Zn pretreatment.	Zinc	0-2	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	51-56
8691507-14	1996	Therefore, Zn pretreatment, possibly by providing elevated MT protein levels at the point of Cd exposure, inhibited the Cd-induced c-myc and c-jun proto-oncogene expression.	Zinc	11-13	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	131-136
9418252-2	1997	The inhibition of the Bacteroides fragilis CfiA and Bacillus cereus II metallo-beta-lactamases was Zn2- dependent, greater inhibition being observed at 1 microM ZnSO4 than at 100 microM ZnSO4.	Zinc	99-102	cfiA	Bacteroides fragilis	43-47
11539267-4	1996	Although Pb2+ and Zn2+ do not catalyze the reaction in the absence of other divalent ions, they significantly modulate the reaction rate when added in the presence of Mg2+, with Pb2+ stimulating the reaction (up to 65-fold) and Zn2+ inhibiting the reaction.	Zinc	18-22	mucin 7, secreted	Homo sapiens	167-170
11539267-4	1996	Although Pb2+ and Zn2+ do not catalyze the reaction in the absence of other divalent ions, they significantly modulate the reaction rate when added in the presence of Mg2+, with Pb2+ stimulating the reaction (up to 65-fold) and Zn2+ inhibiting the reaction.	Zinc	228-232	mucin 7, secreted	Homo sapiens	167-170
8636109-8	1996	Zn2+ was found to be the most effective at enhancing laminin-entactin and laminin-collagen type IV binding.	Zinc	0-4	nidogen 1	Homo sapiens	61-69
15067449-7	1996	Cd(2+) and Zn(2+) are predominantly bound in the labile F1(EXC) and F2(CARB) fractions.	Zinc	11-13	syntaxin 8	Homo sapiens	68-76
8635490-6	1996	However, cells transfected with the wild-type (Rb-binding) large T segment fusion grew slowly, with surviving clones assuming a predominantly tetraploid karyotype and relatively much lower levels of beta-galactosidase activity upon Zn+2 induction.	Zinc	232-236	galactosidase beta 1	Homo sapiens	199-217
8634288-0	1996	Identification of the Zn(II) site in the copper-responsive yeast transcription factor, AMT1: a conserved Zn module.	Zinc	22-28	ammonium permease MEP1	Saccharomyces cerevisiae S288C	87-91
8634288-0	1996	Identification of the Zn(II) site in the copper-responsive yeast transcription factor, AMT1: a conserved Zn module.	Zinc	22-24	ammonium permease MEP1	Saccharomyces cerevisiae S288C	87-91
8634288-3	1996	Site-directed mutagenesis of AMT1 was used in this study to map the ligands of the Cu(I) and Zn(II) ions.	Zinc	93-95	ammonium permease MEP1	Saccharomyces cerevisiae S288C	29-33
8634288-4	1996	The results are consistent with the N-terminal halves of AMT1 and ACE1 consisting of two independent submodules, one binding a single Zn(II) ion and the second binding the tetracopper cluster.	Zinc	134-140	ammonium permease MEP1	Saccharomyces cerevisiae S288C	57-61
8634288-7	1996	We demonstrated previously that population of the Zn(II) site in AMT1 does not alter the ability of the protein to bind DNA but bound Cu(I) ions are essential for DNA binding [Thorvaldsen, J. L., et al.	Zinc	50-53	ammonium permease MEP1	Saccharomyces cerevisiae S288C	65-69
8634288-9	1996	Second, mutations in the N-terminal 42 residue segment reduce the Zn(II) content of purified mutant AMT1 molecules.	Zinc	66-72	ammonium permease MEP1	Saccharomyces cerevisiae S288C	100-104
8634288-10	1996	Third, a synthetic peptide consisting of the N-terminal 42 residues in AMT1 forms a stable Zn(II) complex and substitution with Co(II) reveals an electronic spectrum identical to that of the Co-substituted intact Cu4AMT1 protein.	Zinc	91-97	ammonium permease MEP1	Saccharomyces cerevisiae S288C	71-75
8634288-12	1996	The sequence homology between AMT1, ACE1, and MAC1 in the N-terminal 42 residues suggests that ACE1 and MAC1 will, likewise, contain N-terminal Zn modules.	Zinc	144-146	ammonium permease MEP1	Saccharomyces cerevisiae S288C	30-34
8537405-2	1995	The PDI-calreticulin complex can be dissociated by Zn(2+)-iminodiacetate-substituted Sepharose-agarose chromatography, suggesting that these interactions may be Zn2+-dependent.	Zinc	161-165	prolyl 4-hydroxylase subunit beta	Homo sapiens	4-7
7492590-8	1995	This enzyme is inhibited by Zn2+, F- and very strongly by Ap4 and epsilon-Ap4.	Zinc	28-32	transcription factor AP-4	Homo sapiens	58-61
7492590-8	1995	This enzyme is inhibited by Zn2+, F- and very strongly by Ap4 and epsilon-Ap4.	Zinc	28-32	transcription factor AP-4	Homo sapiens	74-77
7563095-4	1995	We showed by metal analysis and reconstitution of apo-PTPS that Zn(II) was the bound transition metal and responsible for the enzymatic activity.	Zinc	64-70	6-pyruvoyltetrahydropterin synthase	Homo sapiens	54-58
8631882-7	1996	With Zn2+ stimulation of furin expression, the messages of PC2, PC3, and chromogranin A decreased, and the processing of proinsulin to mature insulin became less efficient.	Zinc	5-9	furin (paired basic amino acid cleaving enzyme)	Mus musculus	25-30
7827007-4	1994	The absorption of Zn from the lupin-milk base (26.3%) was significantly higher than from the soya-bean-milk base (17.6%), and neither was significantly altered by the addition of Ca.	Zinc	18-20	5'-nucleotidase, cytosolic IIIA	Homo sapiens	30-35
7827007-5	1994	Overall the absorption of Zn from lupin-protein foods was found to be higher than from comparable soya-bean products.	Zinc	26-28	5'-nucleotidase, cytosolic IIIA	Homo sapiens	34-39
7957253-8	1994	In contrast, deoxyribonuclease gamma, a neutral endonuclease, required both Ca2+ and Mg2+ for full activity and was inhibited by Zn2+.	Zinc	129-133	deoxyribonuclease 1-like 3	Rattus norvegicus	13-36
8605234-6	1996	The data may indicate that the two metal clusters of Zn-MT-1 and Zn-MT-2 differ in their stabilities resulting in differences in their susceptibility towards proteolytic degradation.	Zinc	53-55	metallothionein 2A	Rattus norvegicus	68-72
9018377-7	1996	This approach also indicated the ability of calgizzarin to bind Zn2+.	Zinc	64-68	S100 calcium binding protein A11	Gallus gallus	44-55
8577068-6	1995	The mode of DNA cleavage, 3"-hydroxyl (OH)/5"-phosphoryl (P) ends, by homogeneously purified DNase gamma (Mr = 33 kDa) and its Zn2+ sensitivity match those observed in apoptosis in thymocytes induced by irradiation or glucocorticoid treatment, indicating that this endonuclease is a central component of the thymic apoptosis machinery.	Zinc	127-131	deoxyribonuclease 1-like 3	Rattus norvegicus	93-104
8527508-6	1995	Nuclei from rat ovaries primed with eCG and hCG, but not DES, substantially degraded their DNA in an apoptotic fashion, and this DNA degradation was Ca2+/Mg(2+)-dependent and inhibited by Zn2+.	Zinc	188-192	hypertrichosis 2 (generalised, congenital)	Homo sapiens	44-47
8579959-10	1995	The observed partial inhibition of ATPase and the activation of ATP-dependent Ca uptake of Zn2+ suggest that, in addition to ATPase, some other Ca and/or Pi uptake activators responsive to Zn2+ treatment are present in mammalian matrix vesicles.	Zinc	91-95	dynein axonemal heavy chain 8	Homo sapiens	125-131
8579959-10	1995	The observed partial inhibition of ATPase and the activation of ATP-dependent Ca uptake of Zn2+ suggest that, in addition to ATPase, some other Ca and/or Pi uptake activators responsive to Zn2+ treatment are present in mammalian matrix vesicles.	Zinc	189-193	dynein axonemal heavy chain 8	Homo sapiens	35-41
8597881-12	1995	Interleukin-11 (IL-11) increased the Zn+Dex induction in a dose dependent manner with maximal stimulation at 100 U/mL of 40%.	Zinc	37-39	interleukin 11	Rattus norvegicus	0-14
8597881-12	1995	Interleukin-11 (IL-11) increased the Zn+Dex induction in a dose dependent manner with maximal stimulation at 100 U/mL of 40%.	Zinc	37-39	interleukin 11	Rattus norvegicus	16-21
9328279-5	1997	Purified DNase gamma is active in the presence of both Ca2+ and Mg2+ or Mn2+ alone and inhibited by Co2+, Ni2+, Cu2+, and especially Zn2+.	Zinc	133-137	deoxyribonuclease 1-like 3	Rattus norvegicus	9-20
9380762-7	1997	LCT1 mediated low-affinity uptake of the cations Rb+ and Na+, and possibly allowed Ca2+ but not Zn2+ uptake.	Zinc	96-100	uncharacterized protein LOC542821	Triticum aestivum	0-4
7665992-8	1995	In addition, the recombinant rat MIP-2 and the related rat chemokine, KC/CINC stimulated proliferation of rat alveolar epithelial cells but not fibroblasts in vitro.	Zinc	73-77	C-X-C motif chemokine ligand 2	Rattus norvegicus	33-38
9383367-2	1994	Binding to the hPRL receptor, however, is approximately 50-fold tighter and requires a single Zn2+ cation, unlike binding of hGH to the hGH receptor.	Zinc	94-98	prolactin receptor	Homo sapiens	15-28
8528081-4	1995	In spite of the different location, the C-rich sequence, cloned and over-produced within the last 111 amino acid residues of UME6, UME6(111), forms a binuclear cluster and exhibits a Zn-dependent binding to the URS1 DNA sequence.	Zinc	183-185	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	125-129
8528081-4	1995	In spite of the different location, the C-rich sequence, cloned and over-produced within the last 111 amino acid residues of UME6, UME6(111), forms a binuclear cluster and exhibits a Zn-dependent binding to the URS1 DNA sequence.	Zinc	183-185	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	131-135
8528081-6	1995	UME6(111) contains 1.8 +/- 0.4 mol Zn/mol protein and the Zn can be exchanged for Cd to yield a protein containing 1.9 +/- 0.1 mol Cd/mol protein.	Zinc	35-37	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	0-4
9383367-3	1994	Previous mutational studies have identified putative ligands from hGH and the hPRL receptor responsible for coordinating the interfacial Zn2+.	Zinc	137-141	prolactin receptor	Homo sapiens	78-91
9383367-5	1994	Alanine-scanning mutagenesis showed that the binding site on hGH for the Asn218--&gt;His hGH receptor in the presence of Zn2+ resembled that for the hPRL receptor.	Zinc	121-125	prolactin receptor	Homo sapiens	149-162
7835822-7	1994	In the Zn-deficient rats the concentration of GH in the serum was significantly increased by 78%, while IGF-1 and insulin were significantly reduced by 28% and 25% respectively.	Zinc	7-9	gonadotropin releasing hormone receptor	Rattus norvegicus	46-48
7544912-4	1995	The occurrence of alpha 2M/pMBP-28 complexes was further indicated by crossed immunoelectrophoresis and by use of an anti-alpha 2M affinity column and chelating Sepharose loaded with Zn2+.	Zinc	183-187	progesterone receptor membrane component 2	Homo sapiens	27-31
7835822-8	1994	It is thought that the growth depression observed in the Zn-deficient rats in this study despite their identical feed intake is probably due to a reduced concentration of IGF-I and insulin and that the biological activity or the binding of GH to receptors is impaired in specific alimentary Zn deficiency.	Zinc	57-59	gonadotropin releasing hormone receptor	Rattus norvegicus	240-242
8172613-3	1994	The inhibition of the induction of ODC activity was accompanied by a marked decrease, prevented by Zn2+ supplementation, of the accumulation of immunoreactive ODC protein and ODC mRNA.	Zinc	99-103	ornithine decarboxylase 1	Homo sapiens	35-38
7795236-8	1995	To address these possibilities, we constructed two stable Zn+2-inducible, cyclin D1-overexpressing Dami cell lines.	Zinc	58-62	cyclin D1	Homo sapiens	74-83
8172613-3	1994	The inhibition of the induction of ODC activity was accompanied by a marked decrease, prevented by Zn2+ supplementation, of the accumulation of immunoreactive ODC protein and ODC mRNA.	Zinc	99-103	ornithine decarboxylase 1	Homo sapiens	159-162
9307016-10	1997	Of the bivalent metal ions tested, Co2+, Ni2+, Cu2+ and Zn2+ inhibited DNase gamma activity.	Zinc	56-60	deoxyribonuclease 1-like 3	Rattus norvegicus	71-82
8172613-3	1994	The inhibition of the induction of ODC activity was accompanied by a marked decrease, prevented by Zn2+ supplementation, of the accumulation of immunoreactive ODC protein and ODC mRNA.	Zinc	99-103	ornithine decarboxylase 1	Homo sapiens	159-162
8172613-5	1994	These results indicate that a restricted Zn2+ availability in L1210-DFMOr cells impairs ODC induction remarkably, mainly by affecting the expression of the messenger.	Zinc	41-45	ornithine decarboxylase 1	Homo sapiens	88-91
8003979-3	1994	Binding of Zn or Cd to GAL4 induces the conformation of the protein necessary to recognize the specific DNA sequence, UASG, to which GAL4 binds as a dimer.	Zinc	11-13	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	23-27
9144784-7	1997	Hence, the difference in efficiency of Co2+ and Zn2+ to activate DtxR remains a mystery and might be hidden in the properties of the intriguing second metal-binding site.	Zinc	48-52	MarR family transcriptional regulator	Corynebacterium diphtheriae	65-69
9151945-3	1997	Zn2+ (1 to 100 microM) and Cd2+ (10 microM to 1 microM) enhanced the current through P2X2 purinoceptors.	Zinc	0-4	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	85-89
7784142-3	1995	We evaluated Zn absorption in streptozotocin-induced diabetic rats based on a model of Zn transport in which cysteine-rich intestinal protein serves as an intracellular carrier that is inhibited by metallothionein (MT).	Zinc	87-89	cysteine rich protein 1	Rattus norvegicus	109-141
12228362-2	1995	The relative transcript levels of wali1 (encoding a plant metallothionein-like protein), wali3 and wali5 (putative Bowman-Birk proteinase inhibitors), and wali4 (phenylalanine ammonialyase) increased in root tips of wheat after 2-d treatments with toxic levels of all other metals tested (Cd, Fe, Zn, Cu, Ga, In, and La).	Zinc	297-299	metallothionein-like protein 1	Triticum aestivum	34-39
12228362-2	1995	The relative transcript levels of wali1 (encoding a plant metallothionein-like protein), wali3 and wali5 (putative Bowman-Birk proteinase inhibitors), and wali4 (phenylalanine ammonialyase) increased in root tips of wheat after 2-d treatments with toxic levels of all other metals tested (Cd, Fe, Zn, Cu, Ga, In, and La).	Zinc	297-299	wali4	Triticum aestivum	155-160
8003979-3	1994	Binding of Zn or Cd to GAL4 induces the conformation of the protein necessary to recognize the specific DNA sequence, UASG, to which GAL4 binds as a dimer.	Zinc	11-13	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	133-137
7514921-7	1994	TG+Zn mice had higher plasma IGF-I (p &lt; 0.05) and hepatic IGF-I mRNA (p &lt; 0.05) levels as compared to TG-Zn, C+Zn and C-Zn mice.	Zinc	3-5	insulin-like growth factor 1	Mus musculus	29-34
9115981-0	1997	Importance of two adjacent C-terminal sequences of SNAP-25 in exocytosis from intact and permeabilized chromaffin cells revealed by inhibition with botulinum neurotoxins A and E. Types A and E botulinum neurotoxin (BoNT) are Zn2+-requiring endoproteases which cleave nine and twenty-six residues, respectively, from the C-terminus of synaptosomal-associated protein of Mr = 25 kDa (SNAP-25).	Zinc	225-229	synaptosome associated protein 25	Bos taurus	51-58
7514921-7	1994	TG+Zn mice had higher plasma IGF-I (p &lt; 0.05) and hepatic IGF-I mRNA (p &lt; 0.05) levels as compared to TG-Zn, C+Zn and C-Zn mice.	Zinc	3-5	insulin-like growth factor 1	Mus musculus	61-66
9077140-2	1997	beta-galactosidase reporter activity was inducible by adding Zn2+ ions to the medium (100 microM for 2-4 h).	Zinc	61-65	galactosidase beta 1	Homo sapiens	0-18
7514921-8	1994	Plasma IGF-I and hepatic IGF-I mRNA levels in TG-Zn mice were not different from C+Zn and C-Zn mice.	Zinc	49-51	insulin-like growth factor 1	Mus musculus	25-30
8858095-7	1996	In the present study we show that, in contrast to its effects in rabbit cardiomyocytes, mitochondria, and SMP in which Zn2+ fully blocked IF1-mediated ATPase inhibition, Zn2+ actually enhanced ATPase inhibition in rat cardiomyocytes, although the extent of this effect was limited by the low level of IF1 in rat cardiomyocytes.	Zinc	170-174	dynein axonemal heavy chain 8	Homo sapiens	193-199
7891026-3	1995	The enzyme responsible had a pH optimum of approximately 7.0, was inhibited by serine (di-isopropyl flurophosphate) and thiol (N-ethylmaleimide) protease inhibitors, bacitracin and concentrations of Zn2+ naturally present in seminal plasma: these functional reagents are all known to be potent inhibitors of prolyl endopeptidase.	Zinc	199-203	prolyl endopeptidase	Homo sapiens	308-328
7514921-9	1994	Removal of Zn decreased hepatic IGF-I mRNA levels to C levels in TG mice.	Zinc	11-13	insulin-like growth factor 1	Mus musculus	32-37
7514921-10	1994	Plasma BP-3 and hepatic BP-3 mRNA levels in TG+Zn mice were increased (p &lt; 0.05) as compared to TG-Zn, C-Zn and C+Zn.	Zinc	47-49	bone marrow stromal cell antigen 1	Mus musculus	7-28
8270910-2	1993	We have investigated the interactions between extracellular divalent cations and the ATP-sensitive potassium channel in single guinea pig ventricular cells and found that, under whole-cell patch clamp recording conditions, extracellularly applied Co2+, Cd2+, and Zn2+ block current through the ATP-sensitive K channel (IKATP).	Zinc	263-267	ATP-sensitive inward rectifier potassium channel 11	Cavia porcellus	319-324
8891344-8	1996	The level of induction of Cx43 expression increased with increasing concentration of Zn2+, thus enabling the use of the same clone with different levels of gap junctions present.	Zinc	85-89	gap junction protein alpha 1	Homo sapiens	26-30
8891344-10	1996	Within tumors, the level of expression of Cx43 mRNA and protein corresponded to that seen in vitro following the addition of Zn2+.	Zinc	125-129	gap junction protein alpha 1	Homo sapiens	42-46
8270910-3	1993	The respective Kd"s for block of IKATP by Cd2+ and Zn2+ are 28 and 0.46 microM.	Zinc	51-55	ATP-sensitive inward rectifier potassium channel 11	Cavia porcellus	33-38
8345200-8	1993	Both subunits of clusterin interact with C9 and are similarly potent in inhibiting C5b-9-mediated hemolysis and Zn+(+)-induced C9 polymerization.	Zinc	112-115	clusterin	Homo sapiens	17-26
8665956-7	1996	The bindings of Sg II to both iPr2P-PSA and PCI were influenced by pH, ionic strength, heparin, dextran sulfate, and divalent cations, particularly by Zn2+.	Zinc	151-155	serpin family A member 5	Homo sapiens	44-47
1505684-1	1992	Endopeptidase-24.18 (endopeptidase-2, EC 3.4.24.18, E-24.18) is a Zn-ectoenzyme of rat renal and intestinal microvillar membranes exhibiting an oligomeric structure, alpha 2-beta 2.	Zinc	66-68	meprin A subunit alpha	Rattus norvegicus	21-36
8634235-2	1996	HDH contains 1 mol of Zn(II) per mol of subunit, and removal of this metal abolishes the enzymatic activity.	Zinc	22-28	histidinol dehydrogenase, chloroplastic	Brassica oleracea	0-3
8634235-3	1996	On substitution of Zn(II) with 113Cd(II), the enzyme ([113Cd]HDH) showed similar catalytic activity.	Zinc	19-25	histidinol dehydrogenase, chloroplastic	Brassica oleracea	61-64
1602138-10	1992	Rather, intracellular production of DPPI generated (Leu-Leu)n-OMe metabolites appears to trigger, an additional Zn(2+)-sensitive process that is associated with induction of apoptosis in cells with cytolytic potential.	Zinc	112-118	cathepsin C	Homo sapiens	36-40
1348506-9	1992	Finally, NPY labeling of the 50-kDa receptor was reduced by the heavy metal ions Zn2+, Cu2+, and Hg2+.	Zinc	81-85	neuropeptide Y	Bos taurus	9-12
8745217-6	1996	The DNase I extracted from heart tissue was characterized by: (1) a co-migration with bovine pancreatic DNase I; (2) a pH dependence consistent with DNase I; (3) a dependence of its activity on both Ca2+ and Mg2+ and an inhibition by Zn2+; and (4) an inhibition of its activity in the presence of monomeric rabbit skeletal muscle actin.	Zinc	234-238	deoxyribonuclease 1	Bos taurus	4-11
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	24-30	carbonic anhydrase 2	Bos taurus	47-52
7578122-1	1995	We have found neural nitric oxide synthase (nNOS) activity to be completely and reversibly inhibited by Zn2+ ion with an apparent Ki of 30 microM.	Zinc	104-108	nitric oxide synthase 1	Homo sapiens	14-42
7578122-1	1995	We have found neural nitric oxide synthase (nNOS) activity to be completely and reversibly inhibited by Zn2+ ion with an apparent Ki of 30 microM.	Zinc	104-108	nitric oxide synthase 1	Homo sapiens	44-48
7578122-2	1995	Zn2+ blocks NADPH-dependent reduction of heme iron in nNOS and also blocks the calmodulin-dependent superoxide-mediated cytochrome c reductase activity exhibited by nNOS.	Zinc	0-4	nitric oxide synthase 1	Homo sapiens	54-58
7578122-2	1995	Zn2+ blocks NADPH-dependent reduction of heme iron in nNOS and also blocks the calmodulin-dependent superoxide-mediated cytochrome c reductase activity exhibited by nNOS.	Zinc	0-4	nitric oxide synthase 1	Homo sapiens	165-169
7578122-4	1995	Zn2+ ion induces perturbation difference spectra in nNOS characterized by the appearance of a peak at approximately 430 nm and a trough at approximately 395 nm, with an apparent spectral binding constant of 50 microM.	Zinc	0-4	nitric oxide synthase 1	Homo sapiens	52-56
7578122-5	1995	These spectral changes are consistent with a Zn(2+)-dependent change in the spin-state equilibrium of the heme iron in nNOS.	Zinc	45-51	nitric oxide synthase 1	Homo sapiens	119-123
7578122-7	1995	The estimated maximal change in nNOS absorbance at approximately 418 nm caused by the L-arginine-dependent conversion of the ferric heme iron from hexacoordinate low-spin to pentacoordinate high-spin is increased by 50% in the presence of 50 microM Zn2+, which reflects the increased initial amount of low-spin ferric heme iron present.	Zinc	249-253	nitric oxide synthase 1	Homo sapiens	32-36
7578122-8	1995	These data indicate that Zn(2+)-dependent inhibition of nNOS activity is due to binding of Zn2+ to the hemoprotein domain in the enzyme and that inhibition is associated with perturbations in the environment of the heme iron that appear to block its ability to mediate oxygen reduction.	Zinc	25-31	nitric oxide synthase 1	Homo sapiens	56-60
7578122-8	1995	These data indicate that Zn(2+)-dependent inhibition of nNOS activity is due to binding of Zn2+ to the hemoprotein domain in the enzyme and that inhibition is associated with perturbations in the environment of the heme iron that appear to block its ability to mediate oxygen reduction.	Zinc	91-95	nitric oxide synthase 1	Homo sapiens	56-60
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	188-194	carbonic anhydrase 2	Bos taurus	47-52
1544874-1	1992	When murine erythroleukemia (MEL) cells, containing the transferred rat c-myc gene under the control of human metallothionein II gene promoter, are induced to differentiate with dimethyl sulfoxide, the level of differentiation is dependent on the c-Myc level, which is modulated by the addition of Zn ions.	Zinc	298-300	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	72-77
7641419-1	1995	Aminopeptidase N/CD13 is a Zn(2+)-dependent exoprotease present on the cell surface as a transmembrane protein.	Zinc	27-33	alanyl aminopeptidase, membrane	Homo sapiens	0-16
7641419-1	1995	Aminopeptidase N/CD13 is a Zn(2+)-dependent exoprotease present on the cell surface as a transmembrane protein.	Zinc	27-33	alanyl aminopeptidase, membrane	Homo sapiens	17-21
1733046-1	1992	Recently, our laboratory demonstrated that metallothionein-1 (MT-1) is degraded faster than metallothionein-2 (MT-2) in liver of Zn-treated adult rats; however, it is not clear whether this phenomenon is unique to Zn treatment or the age of the animal.	Zinc	129-131	metallothionein 2A	Rattus norvegicus	111-115
7635142-6	1995	CINC-3 had an activity comparable to other CINCs, but showed a decrease at high concentrations.	Zinc	43-48	C-X-C motif chemokine ligand 2	Rattus norvegicus	0-6
7635142-8	1995	CINC-3 was more potent than the other CINCs and still induced an increase in intracellular [Ca2+] in rat neutrophils stimulated first with other CINCs.	Zinc	38-43	C-X-C motif chemokine ligand 2	Rattus norvegicus	0-6
1654093-4	1991	Since only moderate increases in these enzymes are physiologically meaningful, we chose the following five clones for in-depth characterization: CAT 4 and CAT 12 with 2.6-fold and 4.2-fold increased catalase activities, respectively, SOD 15 and SOD 3 with 2.3-fold and 3.6-fold increased Cu,Zn-SOD activities, respectively, and SOCAT 3 with a 3-fold higher catalase activity and 1.7-fold higher Cu,Zn-SOD activity than the parent JB6 clone 41.	Zinc	291-293	solute carrier family 7 member 4	Homo sapiens	145-150
7635142-8	1995	CINC-3 was more potent than the other CINCs and still induced an increase in intracellular [Ca2+] in rat neutrophils stimulated first with other CINCs.	Zinc	145-150	C-X-C motif chemokine ligand 2	Rattus norvegicus	0-6
1654093-4	1991	Since only moderate increases in these enzymes are physiologically meaningful, we chose the following five clones for in-depth characterization: CAT 4 and CAT 12 with 2.6-fold and 4.2-fold increased catalase activities, respectively, SOD 15 and SOD 3 with 2.3-fold and 3.6-fold increased Cu,Zn-SOD activities, respectively, and SOCAT 3 with a 3-fold higher catalase activity and 1.7-fold higher Cu,Zn-SOD activity than the parent JB6 clone 41.	Zinc	398-400	solute carrier family 7 member 4	Homo sapiens	145-150
7624886-2	1995	After 16 weeks of Cd2+ exposure, an indolent renal failure develops in PCM monkeys which resulted in significant increase in urinary excretion of total protein, Cd2+, Zn2+ and Ca2+ as compared to corresponding to Cd(2+)-treated control group.	Zinc	167-171	CD2 molecule	Macaca mulatta	18-21
1821724-0	1991	Calmodulin activity in tissues of Zn- and Ca- deficient rats.	Zinc	34-36	calmodulin 1	Rattus norvegicus	0-10
7624886-6	1995	These findings suggested that Cd2+ treatment of PCM monkeys caused either a decrease in the number of transporters in the brush border membrane or an increase in the number of less active transporters for Cd2+, Zn2+ and Ca2+.	Zinc	211-215	CD2 molecule	Macaca mulatta	30-33
2039467-14	1991	difference spectroscopic studies indicated a unique Cd2(+)-binding site on the protein, since Cd2+ addition yielded a large positive absorption band in the 240 nm region that is not found with either Ca2+ or Zn2- ions.	Zinc	208-211	CD2 molecule	Bos taurus	52-55
7768908-6	1995	Growth stimulation was enhanced by Zn2+, which preferentially increases the affinity of hGH for the hPRL receptor.	Zinc	35-39	prolactin receptor	Homo sapiens	100-113
2039467-17	1991	Of the two Cd2- -binding sites on the beta-chain, one must be located at the N-terminal end near the single tyrosine residue, since Cd2- and Zn2+ produced similar effects on the intrinsic protein fluorescence.	Zinc	141-145	CD2 molecule	Bos taurus	11-14
7876302-6	1995	The CEP3 product (Cep3p) is a 71-kD protein with a potential DNA-binding domain (binuclear Zn-cluster).	Zinc	91-93	Cep3p	Saccharomyces cerevisiae S288C	4-8
7876302-6	1995	The CEP3 product (Cep3p) is a 71-kD protein with a potential DNA-binding domain (binuclear Zn-cluster).	Zinc	91-93	Cep3p	Saccharomyces cerevisiae S288C	18-23
1716401-3	1991	Furthermore, the Zn-inhibitable MBP-degrading activity was found to be water-soluble and able to recognize MBP also if this protein was protected by its lipidic environment in the native-like, lipid-bound form.	Zinc	17-19	myelin basic protein	Homo sapiens	32-35
7525551-7	1994	Using fluorimetric determinations of pHi, a conductive, Zn(2+)-sensitive alkalinization was observed in neutrophils from both normal and cytochrome b-deficient CGD donors.	Zinc	56-62	glucose-6-phosphate isomerase	Homo sapiens	37-40
7992308-8	1994	Pretreatment of cells with Zn2+ protected them from the effects of Cd2+ on Na(+)-glucose cotransport.	Zinc	27-31	CD2 antigen	Mus musculus	67-70
1716401-3	1991	Furthermore, the Zn-inhibitable MBP-degrading activity was found to be water-soluble and able to recognize MBP also if this protein was protected by its lipidic environment in the native-like, lipid-bound form.	Zinc	17-19	myelin basic protein	Homo sapiens	107-110
7519122-2	1994	MTPR9 cells treated with Zn2+ hence exhibit levels of PML-RAR alpha protein as high as fresh acute promyelocytic leukemia blasts.	Zinc	25-29	PML-RARA regulated adaptor molecule 1	Homo sapiens	54-61
7929196-3	1994	Mutational analyses indicate that one of the Cys-rich Zn2+ binding LIM domains specifically recognizes active but not inactive endocytic codes contained in exon 16.	Zinc	54-58	PDZ and LIM domain 5	Homo sapiens	67-70
1716402-3	1991	Results were indicative of Zn++ ability to bind to MBP.	Zinc	27-31	myelin basic protein	Homo sapiens	51-54
7519122-5	1994	Interestingly, retinoic acid (RA) treatment suppresses the differentiation blockade induced by high level PML-RAR alpha protein; indeed, Zn(2+)-treated MTPR9 cells incubated with RA plus D3 exhibited significant terminal monocytic maturation, comparable to that of cells treated with D3 alone or combined with RA in absence of Zn2+.	Zinc	137-139	PML-RARA regulated adaptor molecule 1	Homo sapiens	106-113
7918572-1	1994	Addition of Zn2+ to cell medium inhibited the induction of ornithine decarboxylase (ODC) activity in ODC overproducing L1210-DFMOr cells.	Zinc	12-16	ornithine decarboxylase 1	Homo sapiens	59-82
2021422-3	1991	The comparisons of insulin structures have shown that the six silver carp insulin molecules have very similar but not identical three-dimensional structures which are similar to the known 2 Zn pig insulin structure but remarkably different in some local conformations.	Zinc	190-192	insulin	Sus scrofa	74-81
7918572-1	1994	Addition of Zn2+ to cell medium inhibited the induction of ornithine decarboxylase (ODC) activity in ODC overproducing L1210-DFMOr cells.	Zinc	12-16	ornithine decarboxylase 1	Homo sapiens	84-87
7918572-1	1994	Addition of Zn2+ to cell medium inhibited the induction of ornithine decarboxylase (ODC) activity in ODC overproducing L1210-DFMOr cells.	Zinc	12-16	ornithine decarboxylase 1	Homo sapiens	101-104
7918572-6	1994	Removal of endogenous Zn2+ by a chelator also provoked a strong decrease of ODC induction, which was reversed by Zn2+.	Zinc	22-26	ornithine decarboxylase 1	Homo sapiens	76-79
7918572-6	1994	Removal of endogenous Zn2+ by a chelator also provoked a strong decrease of ODC induction, which was reversed by Zn2+.	Zinc	113-117	ornithine decarboxylase 1	Homo sapiens	76-79
7918572-8	1994	These results indicate that both a restricted Zn2+ availability and an enhanced presence of the metal can inhibit the induction of ODC in L1210-DFMOr cells.	Zinc	46-50	ornithine decarboxylase 1	Homo sapiens	131-134
8068632-0	1994	Mixed Cu+ and Zn2+ coordination in the DNA-binding domain of the AMT1 transcription factor from Candida glabrata.	Zinc	14-18	ammonium permease MEP1	Saccharomyces cerevisiae S288C	65-69
8068632-3	1994	The Cu-activated AMT1 was shown to contain a Cu(+)-thiolate tetracopper center and a single Zn2+ site.	Zinc	92-96	ammonium permease MEP1	Saccharomyces cerevisiae S288C	17-21
2021422-3	1991	The comparisons of insulin structures have shown that the six silver carp insulin molecules have very similar but not identical three-dimensional structures which are similar to the known 2 Zn pig insulin structure but remarkably different in some local conformations.	Zinc	190-192	insulin	Sus scrofa	74-81
8068632-6	1994	Electrospray mass spectrometry was used to verify that a uniform species was present with 4 Cu+ ions and 1 Zn2+ ion bound per AMT1 molecule.	Zinc	107-111	ammonium permease MEP1	Saccharomyces cerevisiae S288C	126-130
8068632-11	1994	DNA binding by AMT1 was dependent on the tetracopper center but was independent of occupancy of the Zn2+ site.	Zinc	100-104	ammonium permease MEP1	Saccharomyces cerevisiae S288C	15-19
2254304-2	1990	In GAL4, the CysX2CysX6CysX6CysX2CysX6Cys motif has been shown to form a Zn(II)2Cys6 binuclear cluster (Pan, T. and Coleman, J. E. (1990) Proc.	Zinc	73-75	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	3-7
8061228-4	1994	For both the Zn(II)-HSA and Zn(II)-BSA systems, the successive stability constants are basically similar, though such constants for the latter generally slightly larger than those for the former; the order of magnitude of K1 and K2 was found to be approximately 10(5) M-1.	Zinc	13-19	keratin 1	Homo sapiens	222-231
8106444-8	1994	Zn(2+)-induced overexpression of PKC-delta- and PKC-epsilon-stimulated sodium-dependent phosphate uptake.	Zinc	0-2	protein kinase C, epsilon	Mus musculus	48-59
8093058-3	1994	The cognate form of acidic DNases alpha and beta did not require divalent cations for their activities, whereas DNase gamma was a neutral endonuclease that required both Ca2+ and Mg2+ for full activity and was inhibited by Zn2+.	Zinc	223-227	deoxyribonuclease 1-like 3	Rattus norvegicus	112-123
8188630-4	1994	We concluded that the His residue at position 261 is essential for the ligation of the Zn of cabbage HDH.	Zinc	87-89	histidinol dehydrogenase, chloroplastic	Brassica oleracea	101-104
33772997-2	2021	Here, we design a low-concentration aqueous Zn(OTF)2-Zn(NO3)2 electrolyte to in situ form a robust inorganic ZnF2-Zn5(CO3)2(OH)6-organic bi-layer SEI where the inorganic inner layer promotes Zn-ion diffusion while the organic outer layer suppresses water penetration.	Zinc	44-46	zinc finger protein 2	Homo sapiens	109-113
8283289-3	1994	When adult male rats were fed diets with various amounts of zinc, the amount of ileal CRIP mRNA was only 19% lower in rats fed a zinc-deficient diet (1 mg Zn/kg) and was not different in the zinc-supplemented group (180 mg Zn/kg) compared with the zinc-adequate group (30 mg Zn/kg).	Zinc	155-157	cysteine rich protein 1	Rattus norvegicus	86-90
8283289-3	1994	When adult male rats were fed diets with various amounts of zinc, the amount of ileal CRIP mRNA was only 19% lower in rats fed a zinc-deficient diet (1 mg Zn/kg) and was not different in the zinc-supplemented group (180 mg Zn/kg) compared with the zinc-adequate group (30 mg Zn/kg).	Zinc	223-225	cysteine rich protein 1	Rattus norvegicus	86-90
8283289-3	1994	When adult male rats were fed diets with various amounts of zinc, the amount of ileal CRIP mRNA was only 19% lower in rats fed a zinc-deficient diet (1 mg Zn/kg) and was not different in the zinc-supplemented group (180 mg Zn/kg) compared with the zinc-adequate group (30 mg Zn/kg).	Zinc	223-225	cysteine rich protein 1	Rattus norvegicus	86-90
7508748-6	1994	PAPP-A further contains three approximately 26-residue motifs, related to the lin-notch motifs of proteins regulating early tissue differentiation, and, in addition, a putative Zn2+ binding site similar to that found in many metalloproteinases has been identified.	Zinc	177-181	pappalysin 1	Homo sapiens	0-6
33772997-3	2021	Comprehensive characterization reveals that insulating Zn5(OH)8(NO3)2 2H2O layer is first formed on Zn anode surface by self-terminated chemical reaction of NO3- with Zn2+ and OH- generated via HER, and then it transforms into Zn-ion conducting Zn5(CO3)2(OH)6 which in-turn promots ZnF2 formation as the inner layer.	Zinc	55-57	zinc finger protein 2	Homo sapiens	282-286
7591849-4	1994	One of these showed properties almost identical with those of zinc regulatory factor (ZRF), which had been detected using an oligonucleotide probe containing the metal responsive element (MRE); namely, this protein is activated only by Zn, and requires not only MRE but also its flanking sequences for optimal DNA-binding.	Zinc	236-238	metal regulatory transcription factor 1	Homo sapiens	62-84
33772997-3	2021	Comprehensive characterization reveals that insulating Zn5(OH)8(NO3)2 2H2O layer is first formed on Zn anode surface by self-terminated chemical reaction of NO3- with Zn2+ and OH- generated via HER, and then it transforms into Zn-ion conducting Zn5(CO3)2(OH)6 which in-turn promots ZnF2 formation as the inner layer.	Zinc	167-171	zinc finger protein 2	Homo sapiens	282-286
7591849-4	1994	One of these showed properties almost identical with those of zinc regulatory factor (ZRF), which had been detected using an oligonucleotide probe containing the metal responsive element (MRE); namely, this protein is activated only by Zn, and requires not only MRE but also its flanking sequences for optimal DNA-binding.	Zinc	236-238	metal regulatory transcription factor 1	Homo sapiens	86-89
7591849-6	1994	In addition, by Southwestern blotting analysis of nuclear extracts using the 95-bp probe or MRE oligonucleotide probe, we detected a Zn-dependent DNA-binding protein with a molecular mass of 116 kDa, which is likely to be ZRF.	Zinc	133-135	metal regulatory transcription factor 1	Homo sapiens	222-225
8188630-0	1994	Histidinol dehydrogenase loses its catalytic function through the mutation of His261--&gt;Asn due to its inability to ligate the essential Zn.	Zinc	139-141	histidinol dehydrogenase, chloroplastic	Brassica oleracea	0-24
7939382-4	1994	Adding pathophysiologic concentrations of Cd2+, Ca2+, Cu2+, Fe3+, K+, Na+, or Zn2+ to serum and aqueous solutions gave negligible to minimal changes in measured Mg2+.	Zinc	78-82	mucin 7, secreted	Homo sapiens	161-164
33772997-3	2021	Comprehensive characterization reveals that insulating Zn5(OH)8(NO3)2 2H2O layer is first formed on Zn anode surface by self-terminated chemical reaction of NO3- with Zn2+ and OH- generated via HER, and then it transforms into Zn-ion conducting Zn5(CO3)2(OH)6 which in-turn promots ZnF2 formation as the inner layer.	Zinc	100-102	zinc finger protein 2	Homo sapiens	282-286
33804129-4	2021	We found that the highest binding interactions were found with the spike protein (6VYB), with the highest overall binding being observed with Mn-bound Methisazone at -8.3 kcal/mol, followed by Zn and Ca at -8.0 kcal/mol, and Fe and Mg at -7.9 kcal/mol.	Zinc	193-195	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	67-72
8405652-0	1993	Inhibition kinetics of brain butyrylcholinesterase by Cd2+ and Zn2+, Ca2+ or Mg2+ reactivates the inhibited enzyme.	Zinc	63-67	cholinesterase	Ovis aries	29-50
8405652-2	1993	The inhibition kinetics of sheep brain butyrylcholinesterase (BChE) (acylcholine acylhydrolase, EC 3.1.1.8) by Cd2+ and Zn2+ has been studied.	Zinc	120-124	cholinesterase	Ovis aries	39-60
8405652-2	1993	The inhibition kinetics of sheep brain butyrylcholinesterase (BChE) (acylcholine acylhydrolase, EC 3.1.1.8) by Cd2+ and Zn2+ has been studied.	Zinc	120-124	cholinesterase	Ovis aries	62-66
8405652-5	1993	Cd2+ and Zn2+ were the hyperbolic mixed-type inhibitors of BChE.	Zinc	9-13	cholinesterase	Ovis aries	59-63
8405652-8	1993	But when the enzyme was inhibited by 0.1 mM Cd2+ or Zn2+, Ca2+ and Mg2+ reactivated the inhibited form of BChE.	Zinc	52-56	cholinesterase	Ovis aries	106-110
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Zinc	159-163	aminoacylase 1	Homo sapiens	52-66
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Zinc	159-163	aminoacylase 1	Homo sapiens	101-106
8364203-12	1993	The active site His residue may be the target of oxidative inactivation, as evidenced by the partial protection afforded plasmin by the addition of Zn(II), histidine, or the platinum derivative, platinum(II) (2,2":6",2"-terpyridine) chloride.	Zinc	148-151	plasminogen	Homo sapiens	121-128
22897769-8	2012	Proteinase activity was increased by Ca(2+) and Mg(2+), and inhibited by Cu(2+), Zn(2+), Cd(2+), and Fe(2+).	Zinc	81-83	endogenous retrovirus group K member 18	Homo sapiens	0-10
8357837-3	1993	Of 12 histidine and 3 cysteine residues, conserved between the proteins from two species, some are anticipated to form the active site of ACY-1 as either catalytic residues or ligands for an essential Zn2+ atom.	Zinc	201-205	aminoacylase 1	Homo sapiens	138-143
1284246-6	1992	Comparison of the amino acid sequence of porcine ACY-1 with those of other Zn2+-binding metalloenzymes showed no significant homologies in either the overall sequence or the consensus sequences for the metal binding sites.	Zinc	75-79	aminoacylase 1	Homo sapiens	49-54
1331065-5	1992	Phorbol ester activation of acidified cells induced a rapid recovery of pHi partly due to a Zn(2+)-sensitive H(+)-conductive pathway.	Zinc	92-98	glucose-6-phosphate isomerase	Homo sapiens	72-75
8393917-4	1993	Of several metals tested for beta-galactosidase induction and also for their toxicity to HEL cells, Zn was found to be the most suitable for use as an inducer.	Zinc	100-102	galactosidase beta 1	Homo sapiens	29-47
34761291-8	2022	We examined the effects of some metals on cadmium toxicity and suggested (i) that Ca2+ and Zn2+ could exert their protective function against Cd2+ via restoring cadmium-inhibited cellular processes and (ii) that Mg2+ and Mn2+ could have antagonistic roles in an unknown Smf1-independent Cd2+ uptake system.	Zinc	91-95	CD2 antigen	Mus musculus	142-145
8393917-5	1993	In HEL cells infected with the recombinant in the presence of 50 microsM-Zn, beta-galactosidase activity was maximal 3 days after infection, and reached levels 27 times higher than the value obtained in the absence of Zn.	Zinc	73-75	galactosidase beta 1	Homo sapiens	77-95
8393917-5	1993	In HEL cells infected with the recombinant in the presence of 50 microsM-Zn, beta-galactosidase activity was maximal 3 days after infection, and reached levels 27 times higher than the value obtained in the absence of Zn.	Zinc	218-220	galactosidase beta 1	Homo sapiens	77-95
8351953-6	1993	Among the divalent metal ions tested (Zn2+, Mg2+, Mn2+, Ca(2+)--4 mol/l), Zn2+ effected a remarkable increase in [125I]hCG binding to the endometrium (p &lt; 0.005) whereas Mn2+ showed a marginal increase and other metal ions did not have any effect.	Zinc	38-42	chorionic gonadotropin subunit beta 5	Homo sapiens	119-122
8351953-6	1993	Among the divalent metal ions tested (Zn2+, Mg2+, Mn2+, Ca(2+)--4 mol/l), Zn2+ effected a remarkable increase in [125I]hCG binding to the endometrium (p &lt; 0.005) whereas Mn2+ showed a marginal increase and other metal ions did not have any effect.	Zinc	74-78	chorionic gonadotropin subunit beta 5	Homo sapiens	119-122
1325030-6	1992	GABA-activated chloride currents, recorded from GT1-7 cells, were blocked by bicuculline and Zn2+ but were insensitive to diazepam.	Zinc	93-97	retinoic acid induced 1	Mus musculus	48-53
1772633-3	1991	The insulin molecules are arranged as hexamers with two tetrahedrally coordinated Zn atoms in the central channel and one m-cresol bound to each monomer near His B5.	Zinc	82-84	insulin	Sus scrofa	4-11
34761291-8	2022	We examined the effects of some metals on cadmium toxicity and suggested (i) that Ca2+ and Zn2+ could exert their protective function against Cd2+ via restoring cadmium-inhibited cellular processes and (ii) that Mg2+ and Mn2+ could have antagonistic roles in an unknown Smf1-independent Cd2+ uptake system.	Zinc	91-95	CD2 antigen	Mus musculus	287-290
34487945-7	2022	An isotherm study suggested that the adsorption obeyed the Langmuir model, and the derived maximum adsorption capacities for Cr3+, Pb2+, Cu2+, Cd2+, Zn2+, and Ni2+ were 119.6, 377.1, 99.1, 65.2, 53.0, and 58.1 mg/g, respectively.	Zinc	149-153	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	125-128
1998720-3	1991	One model requires Zn2+ metal for the catalytic event, as has been shown for horse liver alcohol dehydrogenase (EC 1.1.1.1, alcohol:NAD+ oxidoreductase).	Zinc	19-23	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	137-151
2205855-8	1990	The increased expression of the GH receptor by Zn2+ was associated with an increased magnitude of GH-stimulated insulin biosynthesis.	Zinc	47-51	gonadotropin releasing hormone receptor	Rattus norvegicus	32-34
8503893-1	1993	The effects of increasing concentrations of Zn(II) and Cd(II) on the expression of the four isometallothioneins (isoMTs), namely MT-1a, MT-2a, MT-2d and MT-2e, in rabbit kidney cells (RK-13) and the development of cellular tolerance to these metal ions were studied.	Zinc	44-50	metallothionein-1A	Oryctolagus cuniculus	129-134
34608720-7	2022	In comparison with the control, Zn-deficit or Zn-excess led to reduced chlorophyll content and PDF 1.2 transcripts induction.	Zinc	32-34	plant defensin 1.2	Arabidopsis thaliana	95-102
2272651-3	1990	The MLP is similar to mammalian hepatic Zn-metallothionein on the basis of its low molecular weight of approximately 7000, 7 g Zn atoms/molecule of MLP and an absorption maximum at 220 nm.	Zinc	40-42	cysteine and glycine rich protein 3	Homo sapiens	4-7
2363684-10	1990	When macrophages incubated with 50 microM-Zn2+ were subsequently incubated with 20 microM-Cd2+, rates of MT synthesis and accretion were decreased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	42-46	CD2 molecule	Gallus gallus	90-93
2363684-10	1990	When macrophages incubated with 50 microM-Zn2+ were subsequently incubated with 20 microM-Cd2+, rates of MT synthesis and accretion were decreased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	42-46	CD2 molecule	Gallus gallus	225-228
2363684-10	1990	When macrophages incubated with 50 microM-Zn2+ were subsequently incubated with 20 microM-Cd2+, rates of MT synthesis and accretion were decreased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	207-211	CD2 molecule	Gallus gallus	90-93
8331595-15	1993	The H+ current blocker Zn2+ (0.5 mM) inhibited pHi recovery from alkalinization at resting membrane potential as well as during depolarization.	Zinc	23-27	glucose-6-phosphate isomerase	Homo sapiens	47-50
34608720-7	2022	In comparison with the control, Zn-deficit or Zn-excess led to reduced chlorophyll content and PDF 1.2 transcripts induction.	Zinc	46-48	plant defensin 1.2	Arabidopsis thaliana	95-102
2363684-11	1990	When macrophages incubated with 20 microM-Cd2+ were subsequently incubated with 50 microM-Zn2+, rates of MT synthesis and accretion were increased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	90-94	CD2 molecule	Gallus gallus	42-45
2363684-11	1990	When macrophages incubated with 20 microM-Cd2+ were subsequently incubated with 50 microM-Zn2+, rates of MT synthesis and accretion were increased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	90-94	CD2 molecule	Gallus gallus	225-228
2363684-11	1990	When macrophages incubated with 20 microM-Cd2+ were subsequently incubated with 50 microM-Zn2+, rates of MT synthesis and accretion were increased as compared with cells continually incubated with 50 microM-Zn2+ or 20 microM-Cd2+.	Zinc	207-211	CD2 molecule	Gallus gallus	42-45
34608720-11	2022	The increased susceptibility to B. cinerea in both Zn-deficient and Zn-excess plants could be related to lack of induction of PDF 1.2 transcripts; oxidative stress could explain higher susceptibility to the necrotroph and lower susceptibility to the biotroph in Zn-deficient plants.	Zinc	68-70	plant defensin 1.2	Arabidopsis thaliana	126-133
34655964-8	2021	The calculated addition of Zn is given as median (p25 - p75).	Zinc	27-29	PC4 and SFRS1 interacting protein 1	Homo sapiens	56-59
2186803-1	1990	The transcription factor GAL4 from Saccharomyces cerevisiae requires Zn(II) or Cd(II) for specific recognition of the UASG sequence (Pan &amp; Coleman, 1989).	Zinc	69-75	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	25-29
2186803-4	1990	GAL4(63) binds tightly 1-2 mol of Zn(II) or 2 mol of Cd(II).	Zinc	34-40	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	0-8
34871934-0	2022	ZnT1 is a neuronal Zn2+/Ca2+ exchanger.	Zinc	19-23	solute carrier family 30 (zinc transporter), member 1	Mus musculus	0-4
34871934-1	2022	Zinc transporter 1 (ZnT1; SLC30A1) is present in the neuronal plasma membrane, critically modulating NMDA receptor function and Zn2+ neurotoxicity.	Zinc	128-132	solute carrier family 30 (zinc transporter), member 1	Mus musculus	0-18
1321133-16	1992	Dephosphorylation of pp160 was especially rapid with a t1/2 of approximately 10 s. The t1/2 for the insulin receptor was 37 s. Zn2+ at 1 mM (a concentration that inhibited the insulin receptor kinase) was a strong inhibitor of dephosphorylation, prolonging the rate of pp160 dephosphorylation more than 12-fold and insulin receptor dephosphorylation 3-fold.	Zinc	127-131	insulin receptor	Rattus norvegicus	100-116
1321133-16	1992	Dephosphorylation of pp160 was especially rapid with a t1/2 of approximately 10 s. The t1/2 for the insulin receptor was 37 s. Zn2+ at 1 mM (a concentration that inhibited the insulin receptor kinase) was a strong inhibitor of dephosphorylation, prolonging the rate of pp160 dephosphorylation more than 12-fold and insulin receptor dephosphorylation 3-fold.	Zinc	127-131	insulin receptor	Rattus norvegicus	176-192
1321133-16	1992	Dephosphorylation of pp160 was especially rapid with a t1/2 of approximately 10 s. The t1/2 for the insulin receptor was 37 s. Zn2+ at 1 mM (a concentration that inhibited the insulin receptor kinase) was a strong inhibitor of dephosphorylation, prolonging the rate of pp160 dephosphorylation more than 12-fold and insulin receptor dephosphorylation 3-fold.	Zinc	127-131	insulin receptor	Rattus norvegicus	176-192
1733046-6	1992	MT-1 had a shorter half-life than MT-2 in Zn-treated adults (21 vs 33 hr) and in nontreated immature rats (49 vs 73 hr).	Zinc	42-44	metallothionein 2A	Rattus norvegicus	34-38
1958667-3	1991	Binding of Zn(II) or Cd(II) to the GAL4 DNA-binding domain is essential to induce the conformation of GAL4 required for the protein to recognize the specific DNA sequence, UASG, to which GAL4 binds.	Zinc	11-17	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	35-39
34871934-1	2022	Zinc transporter 1 (ZnT1; SLC30A1) is present in the neuronal plasma membrane, critically modulating NMDA receptor function and Zn2+ neurotoxicity.	Zinc	128-132	solute carrier family 30 (zinc transporter), member 1	Mus musculus	20-24
34871934-1	2022	Zinc transporter 1 (ZnT1; SLC30A1) is present in the neuronal plasma membrane, critically modulating NMDA receptor function and Zn2+ neurotoxicity.	Zinc	128-132	solute carrier family 30 (zinc transporter), member 1	Mus musculus	26-33
34871934-2	2022	The mechanism mediating Zn2+ transport by ZnT1, however, has remained elusive.	Zinc	24-28	solute carrier family 30 (zinc transporter), member 1	Mus musculus	42-46
1958667-3	1991	Binding of Zn(II) or Cd(II) to the GAL4 DNA-binding domain is essential to induce the conformation of GAL4 required for the protein to recognize the specific DNA sequence, UASG, to which GAL4 binds.	Zinc	11-17	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	102-106
34885360-0	2021	Water Treatment from MB Using Zn-Ag MWCNT Synthesized by Double Arc Discharge.	Zinc	30-32	activity regulated cytoskeleton associated protein	Homo sapiens	64-67
1958667-3	1991	Binding of Zn(II) or Cd(II) to the GAL4 DNA-binding domain is essential to induce the conformation of GAL4 required for the protein to recognize the specific DNA sequence, UASG, to which GAL4 binds.	Zinc	11-17	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	102-106
1709734-2	1991	It also shows moderate catalysis by Mg2+, but not by Ca2+; Zn2+ and Pb2+ are also good catalysts.	Zinc	59-63	mucin 7, secreted	Homo sapiens	36-39
2014261-4	1991	Three of these side chains (His-18, His-21, and Glu-174) are ligands for binding Zn2+, which is required for high-affinity hGH-hPRL receptor complex formation.	Zinc	81-85	prolactin receptor	Homo sapiens	127-140
2015905-0	1991	Phosphorylation of the lymphoid cell kinase p56lck is stimulated by micromolar concentrations of Zn2+.	Zinc	97-101	lymphocyte protein tyrosine kinase	Mus musculus	44-50
2015905-1	1991	In particulate fractions from LSTRA lymphoma cells, tyrosine phosphorylation of the lymphoid specific tyrosine kinase p56lck is elicited by Zn2+ in the absence of other divalent cations.	Zinc	140-144	lymphocyte protein tyrosine kinase	Mus musculus	118-124
2015905-2	1991	Zn2+ alone also induces autophosphorylation of immunoprecipitated p56lck.	Zinc	0-4	lymphocyte protein tyrosine kinase	Mus musculus	66-72
2015905-5	1991	Zn2+ also stimulated p56lck phosphorylation in the presence of Mg2+ ions at physiological concentration, whereas orthovanadate had no effect.	Zinc	0-4	lymphocyte protein tyrosine kinase	Mus musculus	21-27
2015905-6	1991	These results suggest that Zn2+ activates the autophosphorylation of p56lck; this fact could be related with the stimulating effect of Zn2+ in the activation of T lymphocytes.	Zinc	27-31	lymphocyte protein tyrosine kinase	Mus musculus	69-75
2015905-6	1991	These results suggest that Zn2+ activates the autophosphorylation of p56lck; this fact could be related with the stimulating effect of Zn2+ in the activation of T lymphocytes.	Zinc	135-139	lymphocyte protein tyrosine kinase	Mus musculus	69-75
2146159-4	1990	Zn2+ sharply accelerates ATPase activation, probably via binding with the deprotonated form of IF1.	Zinc	0-4	dynein axonemal heavy chain 8	Homo sapiens	25-31
2146159-4	1990	Zn2+ sharply accelerates ATPase activation, probably via binding with the deprotonated form of IF1.	Zinc	0-4	ATP synthase inhibitory factor subunit 1	Homo sapiens	95-98
2400760-12	1990	A significant reduction in pancreatic gamma-glutamyl hydrolase activity before the depletion of many tissue Zn stores confirms the Zn sensitivity of the enzyme.	Zinc	131-133	gamma-glutamyl hydrolase	Rattus norvegicus	38-62
2110145-10	1990	Although overall amino acid identity is only 32%, the Zn ligand-binding His and Cys residues are precisely conserved and the amino acids in the vicinity of these sites show strong similarities (greater than 80%) when the CfiA and Blm proteins are compared.	Zinc	54-56	cfiA	Bacteroides fragilis	221-225
2406262-8	1990	Tat displays its bimodal function only in the presence of Zn2+ ions.	Zinc	58-62	tyrosine aminotransferase	Homo sapiens	0-3
2111549-0	1990	Efficient expression and Zn(II)-dependent structure of the DNA binding domain of the yeast GAL4 protein.	Zinc	25-31	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	91-95
2111549-3	1990	Denaturation--refolding experiments demonstrated that Zn(II) is necessary for maintenance of the conformation of the DNA binding domain of GAL4, as judged on UV-CD and 1H-NMR measurements, as well as for specific DNA binding.	Zinc	54-60	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	139-143
1971138-5	1990	Zn2+ ions exerted an inhibition on both DP IV and SOD activity in a near equimolar concentration.	Zinc	0-4	dipeptidylpeptidase 4	Rattus norvegicus	40-45
2275976-6	1990	The affinity of both the Zn2+ and Cd2+ ions for G.C base pairs is comparable, but the Cd2+ ions interact more extensively with A.T pairs than Zn2+ ions.	Zinc	142-146	CD2 molecule	Bos taurus	86-89
34871934-3	2022	Here, we investigated ZnT1-dependent Zn2+ transport by measuring intracellular changes of this ion using the fluorescent indicator FluoZin-3.	Zinc	37-41	solute carrier family 30 (zinc transporter), member 1	Mus musculus	22-26
34871934-4	2022	In primary mouse cortical neurons, which express ZnT1, transient addition of extracellular Zn2+ triggered a rise in cytosolic Zn2+, followed by its removal.	Zinc	91-95	solute carrier family 30 (zinc transporter), member 1	Mus musculus	49-53
34871934-4	2022	In primary mouse cortical neurons, which express ZnT1, transient addition of extracellular Zn2+ triggered a rise in cytosolic Zn2+, followed by its removal.	Zinc	126-130	solute carrier family 30 (zinc transporter), member 1	Mus musculus	49-53
34871934-5	2022	Knockdown of ZnT1 by adeno associated viral (AAV)-short hairpin RNA (shZnT1) markedly increased rates of Zn2+ rise, and decreased rates of its removal, suggesting that ZnT1 is a primary route for Zn2+ efflux in neurons.	Zinc	105-109	solute carrier family 30 (zinc transporter), member 1	Mus musculus	13-17
34871934-5	2022	Knockdown of ZnT1 by adeno associated viral (AAV)-short hairpin RNA (shZnT1) markedly increased rates of Zn2+ rise, and decreased rates of its removal, suggesting that ZnT1 is a primary route for Zn2+ efflux in neurons.	Zinc	196-200	solute carrier family 30 (zinc transporter), member 1	Mus musculus	13-17
34871934-5	2022	Knockdown of ZnT1 by adeno associated viral (AAV)-short hairpin RNA (shZnT1) markedly increased rates of Zn2+ rise, and decreased rates of its removal, suggesting that ZnT1 is a primary route for Zn2+ efflux in neurons.	Zinc	196-200	solute carrier family 30 (zinc transporter), member 1	Mus musculus	168-172
34970641-0	2021	Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells.	Zinc	18-21	carbonic anhydrase 9	Homo sapiens	53-74
34886901-8	2021	Further studies found that the expression of zinc transport protein ZIP10, which transport Zn2+ from extracellular area into cells, was negatively related to the response of thyroid cancer cells to mannose.	Zinc	91-95	solute carrier family 39 (zinc transporter), member 10	Mus musculus	68-73
34886901-9	2021	Knocking down ZIP10 in mannose-insensitive cells significantly inhibited in vitro and in vivo growth of these cells by decreasing intracellular Zn2+ concentration and enzyme activity of PMI.	Zinc	144-148	solute carrier family 39 (zinc transporter), member 10	Mus musculus	14-19
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Zinc	184-188	transient receptor potential cation channel subfamily V member 4	Homo sapiens	23-28
34562506-7	2021	When HYPX exposure and TRPV4 agonist (GSK1016790A)-induced TRPV4 activity were inhibited by the treatment of ruthenium red or MLT, the increase of mROS, lipid peroxidation, apoptosis, Zn2+ concentrations, TRPV4, caspase -3, caspase -9, Bax, and Bcl-2 expressions were restored via upregulation of reduced glutathione, glutathione peroxidase and total antioxidant status.	Zinc	184-188	transient receptor potential cation channel subfamily V member 4	Homo sapiens	59-64
34791819-2	2021	The analysis of the XANES region of the measured spectra shows that Zn binds to BST2, as well as to orf7a, thus resulting in the formation of BST2-orf7a complexes.	Zinc	68-70	ORF7a protein	Severe acute respiratory syndrome coronavirus 2	100-105
34791819-2	2021	The analysis of the XANES region of the measured spectra shows that Zn binds to BST2, as well as to orf7a, thus resulting in the formation of BST2-orf7a complexes.	Zinc	68-70	ORF7a protein	Severe acute respiratory syndrome coronavirus 2	147-152
34791819-4	2021	Our explanation for this behavior is that, when BST2 gets in contact with Zn bound to the orf7a Cys15 ligand, it has the ability of displacing the metal owing to the creation of a new disulfide bridge across the two proteins.	Zinc	74-76	ORF7a protein	Severe acute respiratory syndrome coronavirus 2	90-95
34559918-9	2021	Our data demonstrate that IRT3, ZIP4, ZIP6 and ZIP9 function redundantly in maintaining Zn homeostasis and seed development in A. thaliana.	Zinc	88-90	iron regulated transporter 3	Arabidopsis thaliana	26-30
34714480-9	2022	Furthermore, when compared to the SS-PC mixes, the VP-PC mixes had 14.7-36.4% lower leached Zn concentrations at different Zn levels.	Zinc	92-94	ATPase H+ transporting V0 subunit c	Homo sapiens	51-56
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	solute carrier family 39 (zinc transporter), member 10	Mus musculus	13-18
33939874-3	2021	The new class of potent and selective CA IX inhibitors combines structural motif of bulky inorganic cluster with an alkylsulfamido or alkylsulfonamido anchor group for Zn2+ ion in the enzyme active site.	Zinc	168-172	carbonic anhydrase 9	Homo sapiens	38-43
34780154-3	2021	By utilizing the optimized electrolyte, the symmetrical Zn battery can stably cycle over 3920 h, which also confers on the Zn-S battery an ultrahigh specific capacity of ~846 mA h gS-1 and energy density of 259 W h kg-1 at 0.5 A g-1.	Zinc	56-58	pseudouridine 5'-phosphatase	Homo sapiens	180-184
34780154-3	2021	By utilizing the optimized electrolyte, the symmetrical Zn battery can stably cycle over 3920 h, which also confers on the Zn-S battery an ultrahigh specific capacity of ~846 mA h gS-1 and energy density of 259 W h kg-1 at 0.5 A g-1.	Zinc	123-127	pseudouridine 5'-phosphatase	Homo sapiens	180-184
33821987-0	2021	Urinary L-erythro-beta-hydroxyasparagine - a novel serine racemase inhibitor and substrate of the Zn2+-dependent D-serine dehydratase.	Zinc	98-102	serine racemase	Homo sapiens	51-66
34885658-8	2021	It was observed that the compounds exhibit the inhibitory potential by specifically interacting with the ZN ion present in the active site of CA-II.	Zinc	105-107	carbonic anhydrase 2	Bos taurus	142-147
34863540-0	2022	RGO/Manganese Silicate/MOF-derived carbon Double-Sandwich-Like structure as the cathode material for aqueous rechargeable Zn-ion batteries.	Zinc	122-124	lysine acetyltransferase 8	Homo sapiens	23-26
34863540-5	2022	This integrated rGO/MnSi/MOF-C with double-sandwich-like structure can not only avert the sluggish electronic conduction progress caused by the conventional three-phase mixture system of rGO, MnSi and MOF-C, but also display promising Zn2+ storing capability.	Zinc	235-239	lysine acetyltransferase 8	Homo sapiens	25-28
34791819-0	2021	Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.	Zinc	0-2	ORF7a protein	Severe acute respiratory syndrome coronavirus 2	43-48
34791819-1	2021	We present in this work a first X-ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS-CoV-2 orf7a proteins as well as with some of their complexes.	Zinc	91-93	ORF7a protein	Severe acute respiratory syndrome coronavirus 2	134-139
34752845-4	2022	Zn2+ release following the activation of TRPM7 disrupted the fusion between autophagosomes and lysosomes by disturbing the interaction between Sxt17 and VAMP8 which determines fusion status of autophagosomes and lysosomes.	Zinc	0-4	vesicle associated membrane protein 8	Homo sapiens	153-158
34707296-7	2021	Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD-Sec14-PH linker.	Zinc	0-2	RAS p21 protein activator 1	Homo sapiens	38-45
34924116-4	2022	Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism.	Zinc	153-155	solute carrier family 39 member 8	Homo sapiens	230-234
34707296-7	2021	Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD-Sec14-PH linker.	Zinc	134-136	RAS p21 protein activator 1	Homo sapiens	38-45
34924116-4	2022	Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism.	Zinc	153-155	solute carrier family 39 member 14	Homo sapiens	240-245
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	forkhead box O3	Rattus norvegicus	159-165
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	glycogen synthase kinase 3 alpha	Rattus norvegicus	167-176
34490697-5	2021	Owing to the efficient charge transfer, the Zn x Cd 1-x S-Pt 1 exhibited outstanding photocatalytic performance of CO 2 to CO, with the highest CO generation rate of 75.31 mumol h -1.	Zinc	44-46	CD1c molecule	Homo sapiens	49-53
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	Janus kinase 1	Rattus norvegicus	189-193
34375103-2	2021	Herein, we report first time the evidence of spodium bonds (SpB"s, an attractive noncovalent force involving elements from group 12 and electron-rich species) in tetrahedral Zn-binding sites.	Zinc	174-176	surfactant protein B	Homo sapiens	60-63
34867993-5	2021	Mechanistically, MT3 increased intramacrophage Zn2+ to downmodulate the TRIF-IRF3-STAT1 axis that is prerequisite for caspase-11 effector function.	Zinc	47-51	interferon regulatory factor 3	Homo sapiens	77-81
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	neurotrophic receptor tyrosine kinase 2	Homo sapiens	14-18
34729500-6	2021	The lupin albumin fraction significantly enhanced Fe2+ and Zn solubility, whilst other fractions generally reduced Zn solubility under fed state.	Zinc	59-61	5'-nucleotidase, cytosolic IIIA	Homo sapiens	4-9
34375103-3	2021	Through a combined crystallographic (PDB analysis) and computational (ab initio calculations) study, we demonstrate that Zn SpB"s are abundant and might be involved in protein structure and enzyme inhibition.	Zinc	121-123	surfactant protein B	Homo sapiens	124-127
34729500-6	2021	The lupin albumin fraction significantly enhanced Fe2+ and Zn solubility, whilst other fractions generally reduced Zn solubility under fed state.	Zinc	115-117	5'-nucleotidase, cytosolic IIIA	Homo sapiens	4-9
34858378-10	2021	The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05).	Zinc	148-150	solute carrier family 30 member 2	Sus scrofa	37-55
34858378-10	2021	The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05).	Zinc	148-150	solute carrier family 30 member 2	Sus scrofa	57-61
34708332-5	2021	Mean body weight, serum concentrations of C-reactive protein, neuropeptide-Y, leptin, insulin fasting blood glucose, and HOMA-IR were statistically decreased by given Zn in HFD + obese + Zn group compared to HFD + obese rats.	Zinc	167-169	leptin	Rattus norvegicus	78-84
34712389-5	2021	Dietary Zn levels had on effect on egg production and fertility (P > 0.05), whereas dietary Zn deficiency decreased breeder plasma Zn concentration and erythrocytic alkaline phosphatase activity at week 6 and inhibited erythrocytic 5"-nucleotidase (5"-NT) activity at weeks 2, 4, and 6 (P < 0.05), indicating that marginal Zn-deficient status occurred after Zn depletion.	Zinc	92-94	5'-nucleotidase ecto	Homo sapiens	232-247
34417961-8	2021	ADAMTSL1 rs17229526 (p = 4.96 x 10-6) was significantly associated with serum Zn element levels.	Zinc	78-80	ADAMTS like 1	Homo sapiens	0-8
34325773-2	2021	Zn2+ is a specific inhibitor of the voltage-dependent proton channel (Hv1).	Zinc	0-4	hydrogen voltage gated channel 1	Homo sapiens	70-73
34323669-5	2021	RESULTS: The results showed that Zn with HFD had induced a significant increase (p < 0.01, p < 0.001) in MAO-A & B levels and a significant decrease (p < 0.001) in the levels of 5-HT, DA, and NA.	Zinc	33-35	monoamine oxidase A	Mus musculus	105-110
34416738-0	2021	Preparation and characterization of Chitosan/graphene oxide nanocomposite coatings on Mg-2 wt % Zn scaffold by pulse electrodeposition process.	Zinc	96-98	citrate synthase	Homo sapiens	36-44
34416738-2	2021	In this research, the nanocomposite coatings of Chitosan (CS)/graphene oxide (GO) were fabricated to improve the corrosion resistance of the Mg-2wt% Zn scaffold.	Zinc	149-151	citrate synthase	Homo sapiens	48-56
34416738-2	2021	In this research, the nanocomposite coatings of Chitosan (CS)/graphene oxide (GO) were fabricated to improve the corrosion resistance of the Mg-2wt% Zn scaffold.	Zinc	149-151	citrate synthase	Homo sapiens	58-60
34479494-3	2021	Se and Zn deficiency might lead to inflammation, oxidative stress, and viral entry into the cells by decreasing ACE-2 expression; three factors that are proposed to be involved in COVID-19 pathogenesis.	Zinc	7-9	angiotensin converting enzyme 2	Homo sapiens	112-117
34639908-4	2021	The primary Al3(Sc1-xZrx) phase promotes recrystallization due to particle-stimulated nucleation (PSN), and acts as the cathode to stimulate an accelerated electrochemical process between the primary Al3(Sc1-xZrx) particles and GBPs, resulting in a sharp decrease of the corrosion resistance in the surface layer of Al-Zn-Mg-Cu-Sc-Zr alloy.	Zinc	319-321	transcription factor 19	Homo sapiens	16-19
34639908-4	2021	The primary Al3(Sc1-xZrx) phase promotes recrystallization due to particle-stimulated nucleation (PSN), and acts as the cathode to stimulate an accelerated electrochemical process between the primary Al3(Sc1-xZrx) particles and GBPs, resulting in a sharp decrease of the corrosion resistance in the surface layer of Al-Zn-Mg-Cu-Sc-Zr alloy.	Zinc	319-321	transcription factor 19	Homo sapiens	204-207
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	glycogen synthase kinase 3 alpha	Rattus norvegicus	132-141
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	Janus kinase 1	Rattus norvegicus	158-162
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	forkhead box O3	Rattus norvegicus	181-187
34162214-6	2021	MFRMs redistribute zinc from neurotoxic amyloid beta zinc (Abeta:Zn) complexes to the cytoplasm facilitating the degradation of Abeta plaques by MMP-2.	Zinc	65-67	matrix metallopeptidase 2	Homo sapiens	145-150
34323669-6	2021	Pretreatment of test drugs with Zn with HFD caused a restoration activity and a significant decrease (p < 0.01, p < 0.05) in MAO-A & B levels and a significant increase (p < 0.05, p < 0.01, p < 0.001) in the level of DA, 5HT and NA as compared to the Zn treated group.	Zinc	32-34	monoamine oxidase A	Mus musculus	125-130
34095624-9	2021	The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.	Zinc	11-13	cellular communication network factor 2	Homo sapiens	114-118
34192687-3	2021	The results also show that Fe doping at Zn sites has a pronounced effect on the electrical transport property together with the V-V distance, accompanied by a decreasing magnetic transition temperature, TN.	Zinc	40-42	C-type lectin domain family 3 member B	Homo sapiens	203-205
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	RAD9 checkpoint clamp component A	Homo sapiens	123-127
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	187-223
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	225-229
34142156-9	2021	The IDC, including the Zn-binding motif, is exposed on the MUTYH surface, suggesting its interaction modes with 9-1-1 and APE1, respectively.	Zinc	23-25	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	122-126
34198528-0	2021	HIF-1alpha Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes.	Zinc	81-85	transient receptor potential cation channel subfamily A member 1	Homo sapiens	54-59
34198528-3	2021	Here, we show that the expression of Zn2+ transporters ZIP8 and ZIP14 is increased via the activation of hypoxia-induced factor 1alpha (HIF-1alpha) in inflammation, leading to (Zn2+)i accumulation, which intrinsically activates transient receptor potential ankyrin 1 (TRPA1) channel and elevates basal (Zn2+)i.	Zinc	177-181	transient receptor potential cation channel subfamily A member 1	Homo sapiens	268-273
34095649-7	2021	Elemental mapping showed that the Zn element was mainly distributed in the outermost layer of the hollow spheres; this might be the critical factor that enabled Ni-doped Zn x Cd1-x S to maintain excellent stability.	Zinc	34-36	CD1c molecule	Homo sapiens	175-178
34095649-7	2021	Elemental mapping showed that the Zn element was mainly distributed in the outermost layer of the hollow spheres; this might be the critical factor that enabled Ni-doped Zn x Cd1-x S to maintain excellent stability.	Zinc	170-172	CD1c molecule	Homo sapiens	175-178
34168809-4	2021	Unlike the case in conventional aqueous electrolytes featuring typical Zn(H2O)6 2+ solvation, a solvation sheath of Zn2+ with the co-participation of the DMC solvent and OTf- anion is found in the formulated H2O + DMC electrolyte, which contributes to the formation of a robust ZnF2 and ZnCO3-rich interphase on Zn.	Zinc	71-73	zinc finger protein 2	Homo sapiens	278-282
34168809-4	2021	Unlike the case in conventional aqueous electrolytes featuring typical Zn(H2O)6 2+ solvation, a solvation sheath of Zn2+ with the co-participation of the DMC solvent and OTf- anion is found in the formulated H2O + DMC electrolyte, which contributes to the formation of a robust ZnF2 and ZnCO3-rich interphase on Zn.	Zinc	116-120	zinc finger protein 2	Homo sapiens	278-282
34168809-4	2021	Unlike the case in conventional aqueous electrolytes featuring typical Zn(H2O)6 2+ solvation, a solvation sheath of Zn2+ with the co-participation of the DMC solvent and OTf- anion is found in the formulated H2O + DMC electrolyte, which contributes to the formation of a robust ZnF2 and ZnCO3-rich interphase on Zn.	Zinc	312-314	zinc finger protein 2	Homo sapiens	278-282
35460952-8	2022	The association with mPC3 (reflecting LDL subclasses) was positive for Cu, Se and Zn, but inverse for Co.	Zinc	82-84	chromobox 8	Mus musculus	21-25
35388851-2	2022	The nano-confinement by macrocycles forces the soft bis-isophthalate axle into a pseudo-rigid conformation and coordinates to zinc(II) ions, affording a two- or three-dimensional MOF under controlled conditions.	Zinc	126-134	lysine acetyltransferase 8	Homo sapiens	179-182
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	Gdi1p	Saccharomyces cerevisiae S288C	39-43
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	Gdi1p	Saccharomyces cerevisiae S288C	144-148
35247821-2	2022	ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca2+, Mg2+ and Zn2+, that block the channel pore.	Zinc	188-192	acid-sensing (proton-gated) ion channel 1	Mus musculus	0-6
35489423-4	2022	Following Zn co-treatment, Cd-mediated increase in IDO 1 protein expression, IDO, and TDO activities, and decrease in antioxidant enzymes, and an increase in markers of inflammatory response and MDA production were significantly (p < 0.05) reversed compared with control.	Zinc	10-12	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	51-56
35489423-4	2022	Following Zn co-treatment, Cd-mediated increase in IDO 1 protein expression, IDO, and TDO activities, and decrease in antioxidant enzymes, and an increase in markers of inflammatory response and MDA production were significantly (p < 0.05) reversed compared with control.	Zinc	10-12	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	77-80
35574354-11	2022	Molecular docking studies showed that Zn2+ and the His201, His205, His211, Glu202, and Ala165 residues of MMP2 contributed to its high affinity for GA-Me.	Zinc	38-42	matrix metallopeptidase 2	Homo sapiens	106-110
35564152-3	2022	In this study, the effect of zinc (Zn) doping on the photoelectric characteristics of SnS2 crystals was explored.	Zinc	35-37	sodium voltage-gated channel alpha subunit 11	Homo sapiens	86-90
35564152-4	2022	The chemical vapor transport method was adopted to grow pristine and Zn-doped SnS2 crystals.	Zinc	69-71	sodium voltage-gated channel alpha subunit 11	Homo sapiens	78-82
35564152-9	2022	The Zn-doped SnS2 crystals had 7.18 and 3.44 times higher photoresponsivity, respectively, than the pristine crystals at a bias voltage of 20 V and a laser power of 4 x 10-8 W. The experimental results of this study indicate that Zn doping markedly enhances the optical response of SnS2 layered crystals.	Zinc	4-6	sodium voltage-gated channel alpha subunit 11	Homo sapiens	13-17
35564152-9	2022	The Zn-doped SnS2 crystals had 7.18 and 3.44 times higher photoresponsivity, respectively, than the pristine crystals at a bias voltage of 20 V and a laser power of 4 x 10-8 W. The experimental results of this study indicate that Zn doping markedly enhances the optical response of SnS2 layered crystals.	Zinc	4-6	sodium voltage-gated channel alpha subunit 11	Homo sapiens	282-286
35344329-1	2022	Three Zn-based alloys (Zn1Cu, Zn2Cu, and Zn3Cu) were developed by the addition of Cu (1, 2, and 3 wt %) into commercially pure Zn.	Zinc	6-8	immunoglobulin kappa variable 1-35	Mus musculus	82-97
35344329-1	2022	Three Zn-based alloys (Zn1Cu, Zn2Cu, and Zn3Cu) were developed by the addition of Cu (1, 2, and 3 wt %) into commercially pure Zn.	Zinc	127-129	immunoglobulin kappa variable 1-35	Mus musculus	82-97
34578719-7	2021	The film with ZnS deposited by PLD and SnS2 and Cu2S by MS was found to be the best for obtaining a single CZTS phase, with uniform surface morphology, a nearly stoichiometric composition, and an optimal band gap of 1.40 eV.	Zinc	14-17	sodium voltage-gated channel alpha subunit 11	Homo sapiens	39-43
34174567-7	2021	Inclusion of 80 and 100 mg/kg Zn as ZH tended to upregulate the expression of claudin-1 (P = 0.088) and tight junction protein-1 (P = 0.086).	Zinc	30-32	tight junction protein 1	Gallus gallus	104-128
34198528-5	2021	Assays with fluorescent Zn2+ indicators revealed that the basal (Zn2+)i concentration was significantly higher in TRPA1-expressing HEK cells and inflammatory FLSs.	Zinc	24-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
34198528-5	2021	Assays with fluorescent Zn2+ indicators revealed that the basal (Zn2+)i concentration was significantly higher in TRPA1-expressing HEK cells and inflammatory FLSs.	Zinc	65-69	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
34198528-6	2021	Moreover, TRPA1 activation induced an elevation of (Zn2+)i level in the presence of 1 muM Zn2+ in inflammatory FLSs.	Zinc	90-94	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-15
34198528-10	2021	Taken together, Zn2+ carrier proteins, TRPA1, ZIP8, and ZIP14, induced under HIF-1alpha mediated inflammation can synergistically change (Zn2+)i in inflammatory FLSs.	Zinc	138-142	transient receptor potential cation channel subfamily A member 1	Homo sapiens	39-44
35611945-4	2022	The pGr-MoS2/GCE exhibited selectivity towards DHBI, in the presence of other toxic contaminants and metal ions such as phenol, dinitrophenol, trinitrophenol, urea and glucose, Hg(II), Ca(II), Ni(II), Zn(II), Cu(II), Na(I) and K(I).	Zinc	201-203	progesterone receptor	Homo sapiens	4-7
35446024-3	2022	This study aimed to engineer TIMP2, one of the four homologous TIMPs, as a potential therapeutic by virtue of its ability to bind to the active-site Zn2+ of MMP-14.	Zinc	149-153	tissue inhibitor of metalloproteinase 2	Mus musculus	29-34
35489423-1	2022	The present study investigated the attenuating effects of Zn following Cd-exposure in the activities/expression of indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-dioxygenase (TDO), oxidative-inflammatory response, behavioral indices and histologic architecture in cerebral cortex and hippocampus of male rats.	Zinc	58-60	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	115-143
35564201-5	2022	The Zn metals in the ZIF-8/PAN or ZDC-850/PAN could be embedded and protected by the PAN fibers from excess volatilization in the following treatments: ZIF-8 had significant pore volumes in the range of 0.9-1.3 nm, but ZDC-850 and ZIF-8/PAN exhibited a distinct peak at approximately 0.5 nm.	Zinc	4-6	adenosine deaminase 2	Homo sapiens	21-30
35564201-5	2022	The Zn metals in the ZIF-8/PAN or ZDC-850/PAN could be embedded and protected by the PAN fibers from excess volatilization in the following treatments: ZIF-8 had significant pore volumes in the range of 0.9-1.3 nm, but ZDC-850 and ZIF-8/PAN exhibited a distinct peak at approximately 0.5 nm.	Zinc	4-6	adenosine deaminase 2	Homo sapiens	231-240
35459748-3	2022	Dbr1 is a member of the metallophosphoesterase (MPE) family of enzymes, and recent X-ray crystal structures and biochemistry data demonstrate that Dbr1 from Entamoeba histolytica uses combinations of Mn2+, Zn2+, and Fe2+ as enzymatic co-factors.	Zinc	206-210	debranching RNA lariats 1	Homo sapiens	0-4
35459748-3	2022	Dbr1 is a member of the metallophosphoesterase (MPE) family of enzymes, and recent X-ray crystal structures and biochemistry data demonstrate that Dbr1 from Entamoeba histolytica uses combinations of Mn2+, Zn2+, and Fe2+ as enzymatic co-factors.	Zinc	206-210	debranching RNA lariats 1	Homo sapiens	147-151
35559187-4	2022	The results indicated that CO2 coordination modes of eta1 (C) and eta2 (O, O) with Zn in ZnCl2/EA (1:4) TDESs are conceivable.	Zinc	83-85	DNA polymerase iota	Homo sapiens	66-70
35279148-2	2022	Here, hybrid lead sulfide/zinc sulfide quantum dots (PbS/ZnS QDs) nanostructures emitting in the long-wavelength end of the second near-infrared (NIR-IIb) window were synthesized and conjugated with Ribonuclease-A (RNase A).	Zinc	57-60	ribonuclease A family member 1, pancreatic	Homo sapiens	199-213
35279148-2	2022	Here, hybrid lead sulfide/zinc sulfide quantum dots (PbS/ZnS QDs) nanostructures emitting in the long-wavelength end of the second near-infrared (NIR-IIb) window were synthesized and conjugated with Ribonuclease-A (RNase A).	Zinc	57-60	ribonuclease A family member 1, pancreatic	Homo sapiens	215-222
35279148-4	2022	This will allow the RNase A@PbS/ZnS QDs to provide stable fluorescence signals for long-time intraoperative imaging navigation, despite often happened, undesirable thermal accumulation in vivo.	Zinc	32-35	ribonuclease A family member 1, pancreatic	Homo sapiens	20-27
35350365-3	2022	Here, we propose to use the ZnS shell for defect passivation and Cu ion doping for band structure engineering to design and synthesize a series of Cu x Ag1-x InS2/ZnS CQDs.	Zinc	28-31	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	152-155
35110603-8	2022	Performed 50 ns of MD simulations on top three hits were retained the salient pi-stacking, Zn2+ coordination, hydrogen bonding, and hydrophobic interactions with catalytic residues from the active site pocket of HDAC3.	Zinc	91-95	histone deacetylase 3	Homo sapiens	212-217
35174244-6	2022	Different levels of Zn can increase the mRNA expression of occluding (OCLN) and zonula occludens-1 (ZO-1) in the jejunum (P < 0.05).	Zinc	20-22	OCLN	Anas platyrhynchos	70-74
35368228-2	2022	Zn is a part of several enzymes involved in the metabolism of protein, fat, carbohydrates, and nucleic acids.	Zinc	0-2	FAT atypical cadherin 1	Gallus gallus	71-74
35357432-5	2022	Accumulated Zn in thymocytes during development was released into the extracellular milieu after HSCT conditioning, where it triggered regeneration by stimulating endothelial cell-production of BMP4 via the cell surface receptor GPR39.	Zinc	12-14	G protein-coupled receptor 39	Mus musculus	229-234
35357432-6	2022	Dietary supplementation of Zn was sufficient to promote thymic function in a mouse model of allogeneic HSCT, including enhancing the number of recent thymic emigrants in circulation; although direct targeting of GPR39 with a small molecule agonist enhanced thymic function without the need for prior Zn accumulation in thymocytes.	Zinc	27-29	G protein-coupled receptor 39	Mus musculus	212-217
35357432-6	2022	Dietary supplementation of Zn was sufficient to promote thymic function in a mouse model of allogeneic HSCT, including enhancing the number of recent thymic emigrants in circulation; although direct targeting of GPR39 with a small molecule agonist enhanced thymic function without the need for prior Zn accumulation in thymocytes.	Zinc	300-302	G protein-coupled receptor 39	Mus musculus	212-217
35254605-2	2022	The chemical composition of mud is complex, rich in Ca2+, Zn2+, Mg2+, Na+ and other mineral elements, also contains organic matter such as humic acid, fulvic acid and acetic acid.	Zinc	58-62	adaptor related protein complex 5 subunit mu 1	Homo sapiens	28-31
34631042-7	2021	Leptin had a positive correlation with inflammatory factors and lipid peroxidation marker and showed an inverse relationship with Zn and Se levels and anti-oxidative enzymes(p < .05).	Zinc	130-132	leptin	Rattus norvegicus	0-6
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	58-60	zinc finger protein 2	Homo sapiens	204-208
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	189-191	zinc finger protein 2	Homo sapiens	50-54
34112355-3	2021	In parallel with the revealed tight association between ASD risk and severity and Zn status, the particular mechanisms linking Zn2+ and ASD pathogenesis like modulation of synaptic plasticity through ProSAP/Shank scaffold, neurotransmitter metabolism, and gut microbiota, have been elucidated.	Zinc	127-131	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	207-212
35119870-5	2022	Therefore, ZnF2-Ag@Zn exhibits the electrochemical performance much better than ZnF2@Zn or Ag@Zn.	Zinc	19-21	zinc finger protein 2	Homo sapiens	11-15
35119870-6	2022	Even at -40  C, the full cells using ZnF2-Ag@Zn demonstrate an ultralong lifespan of 5000 cycles with a capacity retention of almost 100%.	Zinc	45-47	zinc finger protein 2	Homo sapiens	37-41
35038675-10	2022	Heterogeneous complementation analysis showed that CsZIP1, CsZIP2, CsZIP7 and CsZIP8 could complement the Zn sensitivity of  zrc1cot1 yeast double mutant.	Zinc	106-108	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	125-133
34651564-2	2021	The formation of Zn2+-decorated P-MOFs was confirmed by FT-IR spectroscopy, energy-dispersive spectroscopy, X-ray diffraction, BET surface area analysis and TGA.	Zinc	17-21	delta/notch like EGF repeat containing	Homo sapiens	127-130
35636252-1	2022	Zinc (Zn) transporter ZIP8, encoded by SLC39A8, is a unique transporter that can transport divalent manganese (Mn) and cadmium (Cd) in addition to Zn.	Zinc	147-149	solute carrier family 39 member 8	Homo sapiens	22-26
34935828-2	2022	Here, we explore the pyrazolo(4,3-b)pyridine (HL1) and pyrazolo(3,4-c)pyridine (HL2) backbones and their N-substituted derivatives, using their coordination chemistry with zinc(II) in the solid state and in solution to examine the steric and electronic effects of varying their substitution pattern.	Zinc	172-180	intelectin 2	Homo sapiens	80-83
35054635-3	2022	The microscopic observation and the analysis of the BET surface area of CH/Zn@H3BTC nanocomposites indicated that chitosan plays an important role in controlling the surface morphology and surface properties of the Zn@H3BTC.	Zinc	75-77	delta/notch like EGF repeat containing	Homo sapiens	52-55
35054635-3	2022	The microscopic observation and the analysis of the BET surface area of CH/Zn@H3BTC nanocomposites indicated that chitosan plays an important role in controlling the surface morphology and surface properties of the Zn@H3BTC.	Zinc	215-217	delta/notch like EGF repeat containing	Homo sapiens	52-55
35011531-7	2022	The real advantage of the Cu-Zn system over FAU and MFI in hydrothermal conditions has been demonstrated in comparison to a conventional Cu-Cu catalyst.	Zinc	29-31	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	44-47
35425094-1	2021	Water-soluble nanocomposites based on CdSe/ZnS quantum dots (QDs) and hydrophobic tetraphenylporphyrin (TPP) molecules passivated by chitosan (CS) have been formed.	Zinc	43-46	citrate synthase	Homo sapiens	143-145
35432786-5	2022	They also underwent stable docking to the Zn2+ domain of the ACE2 catalytic site as well as the critical interfacial region between ACE2 and the SARS-CoV-2 receptor binding domain.	Zinc	42-46	angiotensin converting enzyme 2	Homo sapiens	61-65
2761409-1	1989	Recent studies demonstrating decreases in transport kinetics of zinc (Zn) in testis in response to calcitonin (CT) and the presence of CT receptors on Leydig cells has suggested a physiological interrelationship between CT and cellular Zn metabolism in the testis.	Zinc	70-72	calcitonin-related polypeptide alpha	Rattus norvegicus	99-109
2761409-1	1989	Recent studies demonstrating decreases in transport kinetics of zinc (Zn) in testis in response to calcitonin (CT) and the presence of CT receptors on Leydig cells has suggested a physiological interrelationship between CT and cellular Zn metabolism in the testis.	Zinc	70-72	calcitonin-related polypeptide alpha	Rattus norvegicus	111-113
2761409-1	1989	Recent studies demonstrating decreases in transport kinetics of zinc (Zn) in testis in response to calcitonin (CT) and the presence of CT receptors on Leydig cells has suggested a physiological interrelationship between CT and cellular Zn metabolism in the testis.	Zinc	236-238	calcitonin-related polypeptide alpha	Rattus norvegicus	135-137
2761409-1	1989	Recent studies demonstrating decreases in transport kinetics of zinc (Zn) in testis in response to calcitonin (CT) and the presence of CT receptors on Leydig cells has suggested a physiological interrelationship between CT and cellular Zn metabolism in the testis.	Zinc	236-238	calcitonin-related polypeptide alpha	Rattus norvegicus	135-137
2761409-10	1989	There does appear, nevertheless, to be a role for CT in the modulation of transmembrane Zn transport.	Zinc	88-90	calcitonin-related polypeptide alpha	Rattus norvegicus	50-52
2544227-2	1989	Addition of the Zn2+, Cd2+ and Cu2+ chelator o-phenanthroline destroyed the matrix fibrils and the binding affinity of Tat to the matrix.	Zinc	16-20	tyrosine aminotransferase	Homo sapiens	119-122
2620574-6	1989	This study suggests that maternal serum Ca, Cu and Zn are related to PIH, and Ca might have a causal role in the development of PIH.	Zinc	51-53	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	69-72
34934014-5	2022	Focusing on striatal neurons, we show that the dominant isoform KCTD5 exerts its effects through an unusual mechanism that modulates the influx of Zn2+ via the Zip14 transporter to exert unique allosteric effects on AC.	Zinc	147-151	solute carrier family 39 (zinc transporter), member 14	Mus musculus	160-165
35636252-1	2022	Zinc (Zn) transporter ZIP8, encoded by SLC39A8, is a unique transporter that can transport divalent manganese (Mn) and cadmium (Cd) in addition to Zn.	Zinc	147-149	solute carrier family 39 member 8	Homo sapiens	39-46
35158192-2	2022	In this work, SnS2 nanosheets are grown on ZnS polyhedron cages to fabricate hierarchical ZnS@SnS2 double-shelled heterostructured cages.	Zinc	43-46	sodium voltage-gated channel alpha subunit 11	Homo sapiens	14-18
2696286-1	1989	We present preliminary evidence that Selenium (Se) enhances zinc (Zn) accumulation in cultured skin fibroblasts from fetuses with NTD.	Zinc	66-68	fuzzy planar cell polarity protein	Homo sapiens	130-133
2696286-2	1989	Zn accumulation was decreased in NTD cells compared to controls and was increased but remained below the basal levels of controls when a 3-fold dose of Se was added to the culture media for 48 hours prior to the addition of Zn.	Zinc	0-2	fuzzy planar cell polarity protein	Homo sapiens	33-36
2706244-2	1989	ER from both crude and highly purified preparations binds to metal-containing adsorbents complexed with Zn(II), Ni(II), Co(II), and Cu(II), but not to those complexed with Fe(II) and Cd(II).	Zinc	104-110	estrogen receptor 1	Bos taurus	0-2
2706244-4	1989	Analysis of affinity-labeled ER by [3H]tamoxifen aziridine after elution from a column of Zn(II)-charged iminodiacetate-Sepharose showed that ER fragments obtained by extensive trypsinization were also bound.	Zinc	90-96	estrogen receptor 1	Bos taurus	29-31
2706244-4	1989	Analysis of affinity-labeled ER by [3H]tamoxifen aziridine after elution from a column of Zn(II)-charged iminodiacetate-Sepharose showed that ER fragments obtained by extensive trypsinization were also bound.	Zinc	90-96	estrogen receptor 1	Bos taurus	142-144
35158192-2	2022	In this work, SnS2 nanosheets are grown on ZnS polyhedron cages to fabricate hierarchical ZnS@SnS2 double-shelled heterostructured cages.	Zinc	43-46	sodium voltage-gated channel alpha subunit 11	Homo sapiens	94-98
35158192-2	2022	In this work, SnS2 nanosheets are grown on ZnS polyhedron cages to fabricate hierarchical ZnS@SnS2 double-shelled heterostructured cages.	Zinc	90-93	sodium voltage-gated channel alpha subunit 11	Homo sapiens	14-18
2457650-8	1988	A second effect was evident only in the presence of added calcium ions, when lower concentrations of Zn2+ (less than 0.1 mM) inhibited MBP-membrane dissociation and the accumulation of intact MBP in incubation media.	Zinc	101-105	myelin basic protein	Homo sapiens	135-138
2457650-8	1988	A second effect was evident only in the presence of added calcium ions, when lower concentrations of Zn2+ (less than 0.1 mM) inhibited MBP-membrane dissociation and the accumulation of intact MBP in incubation media.	Zinc	101-105	myelin basic protein	Homo sapiens	192-195
2548756-2	1989	FDP is able to inhibit Ca++ entry into the myocardial tissue with an IC50 value of 11.5 mM and in addition, it is bound by rat heart slices, the binding being activated by Zn and conditions of chemical hypoxia induced by KCN and iodoacetate.	Zinc	172-174	fructose-bisphosphatase 1	Rattus norvegicus	0-3
2706244-5	1989	Zn(II) and the same other metals able to bind ER, when immobilized on resins, inhibit the binding of estradiol to the receptor at micromolar concentrations.	Zinc	0-6	estrogen receptor 1	Bos taurus	46-48
35158192-2	2022	In this work, SnS2 nanosheets are grown on ZnS polyhedron cages to fabricate hierarchical ZnS@SnS2 double-shelled heterostructured cages.	Zinc	90-93	sodium voltage-gated channel alpha subunit 11	Homo sapiens	94-98
2837338-0	1988	Effect of Ca2+ and Zn2+ on 5"-nucleotidase activity in rat liver plasma membranes: hepatic calcium-binding protein (regucalcin) reverses the Ca2+ effect.	Zinc	19-23	5' nucleotidase, ecto	Rattus norvegicus	27-42
35158192-4	2022	Benefiting from these advantages, the optimized hierarchical ZnS@SnS2 heterostructured cages exhibit significant gas-phase CO2 photoreduction activity with a CO generation rate of 95.38 mumol g-1h-1 and 72.4% CO selectivity, which are greatly improved in comparison with those of pure ZnS cages and nanosheet-assembled SnS2 particles.	Zinc	61-64	sodium voltage-gated channel alpha subunit 11	Homo sapiens	65-69
35158192-4	2022	Benefiting from these advantages, the optimized hierarchical ZnS@SnS2 heterostructured cages exhibit significant gas-phase CO2 photoreduction activity with a CO generation rate of 95.38 mumol g-1h-1 and 72.4% CO selectivity, which are greatly improved in comparison with those of pure ZnS cages and nanosheet-assembled SnS2 particles.	Zinc	61-64	sodium voltage-gated channel alpha subunit 11	Homo sapiens	319-323
35158192-4	2022	Benefiting from these advantages, the optimized hierarchical ZnS@SnS2 heterostructured cages exhibit significant gas-phase CO2 photoreduction activity with a CO generation rate of 95.38 mumol g-1h-1 and 72.4% CO selectivity, which are greatly improved in comparison with those of pure ZnS cages and nanosheet-assembled SnS2 particles.	Zinc	285-288	sodium voltage-gated channel alpha subunit 11	Homo sapiens	65-69
3119587-1	1987	We have measured the pH dependence of kcat and kcat/Km for CO2 hydration catalyzed by both native Zn2+-and metallo-substituted Co2+-bovine carbonic anhydrase II in the absence of inhibitory ions.	Zinc	98-102	carbonic anhydrase 2	Bos taurus	139-160
3261961-12	1988	Chelator-inhibited PPH could be reactivated by bivalent metal ions, Zn2+ being the most effective.	Zinc	68-72	meprin A subunit alpha	Homo sapiens	19-22
35158192-6	2022	The optimized ZnS@SnS2/CdS hybrid exhibits a CO generation rate of 155.57 mumol g-1h-1 and an excellent selectivity of 80.4%.	Zinc	14-17	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
3185538-6	1988	The binding of Cu2+ and Zn2+ ions to parvalbumin and alpha-lactalbumin changes the shape and position of their thermal denaturation transitions.	Zinc	24-28	parvalbumin	Bos taurus	37-48
35460952-10	2022	These associations were mainly driven by Cu and Sb for mPC1; Se, Zn and Cd for mPC2; Co, Se and Zn for mPC3; and Zn for mPC4.	Zinc	96-98	chromobox 8	Mus musculus	103-107
3040753-18	1987	However, Hg2+, Zn2+, and Cu2+ inhibited both PLC-I and PLC-II, with PLC-II exhibiting much higher sensitivity to these metal ions than PLC-I.	Zinc	15-19	phospholipase C beta 1	Bos taurus	45-50
3040753-18	1987	However, Hg2+, Zn2+, and Cu2+ inhibited both PLC-I and PLC-II, with PLC-II exhibiting much higher sensitivity to these metal ions than PLC-I.	Zinc	15-19	phospholipase C beta 1	Bos taurus	55-60
3299061-7	1987	The lesions harbored by all three rpo21 Ts- alleles lie in DNA sequence domains that are highly conserved among genes that encode the largest subunits of RNAP from a variety of eucaryotes; one mutation lies in a possible Zn2+ binding domain.	Zinc	221-225	DNA-directed RNA polymerase II core subunit RPO21	Saccharomyces cerevisiae S288C	34-39
35584675-5	2022	In vitro, Zng1p can transfer Zn2+ or Co2+ to apo-Map1p, but unlike characterized copper chaperones, transfer is dependent on GTP hydrolysis.	Zinc	29-33	methionine aminopeptidase MAP1	Saccharomyces cerevisiae S288C	49-54
3492923-2	1987	We studied the role of granulocytes and lactoferrin (LF) in endotoxin and murine interleukin 1 (IL-1)-induced depression of serum Fe and Zn concentrations in both rabbits and rats.	Zinc	137-139	interleukin 1 complex	Mus musculus	81-100
35637170-6	2022	The optimum pH for alpha-galactosidase T26GAL was determined to be 8.0, while the optimum temperature was 60 C. In addition, T26GAL demonstrated a remarkable thermostability with more than 93% enzyme activity, even at a high temperature of 90 C. Furthermore, Ca2+ and Mg2+ promoted the activity of T26GAL while Zn2+ and Cu2+ inhibited it.	Zinc	311-315	alpha-galactosidase	Parageobacillus thermoglucosidasius	19-38
20501097-8	1987	Cu and Zn were similar to control in the sciatic nerve of quaking and shiverer.	Zinc	7-9	myelin basic protein	Mus musculus	70-78
35600978-6	2023	We further proved that Zn2+ released from ZnO NPs induced downregulation of beta-catenin expression via HIF-1alpha/BNIP3/LC3B-mediated mitophagy pathway.	Zinc	23-27	microtubule associated protein 1 light chain 3 beta	Homo sapiens	121-125
35388972-0	2022	Atomic Engineering Catalyzed Redox Kinetics of Nix Co1-x (OH)2 on Nanoporous Phosphide Electrode for Efficient Ni-Zn Batteries.	Zinc	114-116	BCL2 interacting protein 3 like	Homo sapiens	47-50
3527222-4	1986	It was found that all of these ions bring about association of this insulin analogue; Zn2+ and Cd2+ to a more marked degree than Pb2+ and Ca2+.	Zinc	86-90	insulin	Sus scrofa	68-75
35269130-7	2022	The number of strong MBN pulses drops down with the increasing thickness of Zn coating at the expense of the increasing number of the weak MBN pulses.	Zinc	76-78	proteinase 3	Homo sapiens	21-24
3465328-5	1986	High salt concentration and Mg2+, Mn2+, and Zn2+ inhibited lung PST.	Zinc	44-48	sulfotransferase family 1A member 1	Homo sapiens	64-67
35269130-7	2022	The number of strong MBN pulses drops down with the increasing thickness of Zn coating at the expense of the increasing number of the weak MBN pulses.	Zinc	76-78	proteinase 3	Homo sapiens	139-142
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	8-10	zinc finger protein 2	Homo sapiens	27-31
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	8-10	zinc finger protein 2	Homo sapiens	50-54
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	8-10	zinc finger protein 2	Homo sapiens	204-208
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	58-60	zinc finger protein 2	Homo sapiens	27-31
35119870-3	2022	Herein, Zn foils coated by ZnF2-Ag nanoparticles (ZnF2-Ag@Zn) are used as a model to modulate the desolvation and nucleation processes by hybrid surfaces, where Ag has a strong affinity to Zn adatoms and ZnF2 shows an intense adsorption to H2O.	Zinc	58-60	zinc finger protein 2	Homo sapiens	50-54
35112232-3	2022	Eleven studies were identified and used to analyze the effect of diets with or without Zn supplementation on feed intake, feed conversion ratio (FCR), hen day egg production (HDEP), egg weight (EW), egg mass (EM), Haugh unit (HU) scores, eggshell thickness (EST), eggshell weight (ESW), and blood Zn concentrations in laying hens.	Zinc	87-89	FCR	Gallus gallus	122-143
6510399-4	1984	Ag-metallothionein (MT), which is associated with Ag, Cu, and Zn, and Cd-MT, which is associated with Cd, Cu, and Zn, were induced in the liver by the injection of Ag and Cd, respectively.	Zinc	114-116	CYLD lysine 63 deubiquitinase	Mus musculus	70-75
35112232-3	2022	Eleven studies were identified and used to analyze the effect of diets with or without Zn supplementation on feed intake, feed conversion ratio (FCR), hen day egg production (HDEP), egg weight (EW), egg mass (EM), Haugh unit (HU) scores, eggshell thickness (EST), eggshell weight (ESW), and blood Zn concentrations in laying hens.	Zinc	87-89	FCR	Gallus gallus	145-148
6692819-5	1984	The Ap4Aase activity, which catalyzes the phosphohydrolysis of Ap4A to ATP and AMP, is strongly inhibited by low levels (50-100 microM) of Zn2+ without any effect on the Ap4A binding protein activity.	Zinc	139-143	nudix hydrolase 2	Bos taurus	4-11
35014656-4	2022	In order to find an effective way of reducing N2 into NH3, in this work, PC6 monolayers with good electro-optical properties and eight transition metals (V, Cr, Mn, Fe, Co, Ni, Cu, Zn) are chosen to construct PC6-TM3 and PC6-TM4 single cluster catalysts (SCCs), which are proved to have low overpotential, multiple active-sites and superior activity.	Zinc	181-183	proprotein convertase subtilisin/kexin type 5	Homo sapiens	73-76
6308919-8	1983	Key enzymes of energetic utilization of carbohydrates such as fructose-1.6-biphosphatase and glucose-6-phosphate dehydrogenase were reduced in their activities in livers and kidneys of Zn-deficient animals.	Zinc	185-187	glucose-6-phosphate dehydrogenase	Rattus norvegicus	93-126
6298535-2	1982	The carboxyl coordinating ability of the Zn atom seems to be significantly higher in ACE than in "enkephalinase".	Zinc	41-43	membrane metallo endopeptidase	Mus musculus	98-112
35013289-3	2022	Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn2+) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and molecular clicking strategy.	Zinc	80-84	bone morphogenetic protein 2	Homo sapiens	127-132
6816281-5	1982	Adult flies that had developed on a normal diet also responded to divalent ions; Hg2+ as well as Cd2+, Sr2+ and Zn2+ caused an increase in Q(+)tRNATyr in 4 days.	Zinc	112-116	transfer RNA:Tyrosine-GTA 1-9	Drosophila melanogaster	143-150
35013289-4	2022	Compared to the bare TiO2 group, Zn2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%.	Zinc	33-37	bone morphogenetic protein 2	Homo sapiens	195-200
2692787-1	1989	When murine erythroleukemia (MEL) cells, having the transferred rat c-myc gene under the control of human metallothionein II gene promoter, are induced to differentiate with dimethyl sulfoxide (DMSO), the level of differentiation is dependent on the c-myc levels which are modulated by the Zn++ ion.	Zinc	290-294	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	68-73
6254760-4	1980	Spectral overlap exists between the fluorescence of porphyrin, Zn(II) or Sn(IV) cytochrome c and the absorption of the heme of cytochrome b; therefore dipole-dipole interaction is possible as predicted by Forster"s theory of energy transfer.	Zinc	63-65	cytochrome b	Saccharomyces cerevisiae S288C	127-139
2689597-0	1989	LHRH interaction with Zn(II) ions.	Zinc	22-28	gonadotropin releasing hormone 1	Homo sapiens	0-4
126684-1	1975	The Ca2+-sensitive ATPase (adenosine triphosphatase) of human erythrocyte membranes is activated, not only by Ca2+ ions, but also by a series of other bivalent metal ions including Sr2+, Ba2+, Mn2+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+ and Pb2+.	Zinc	223-227	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	27-51
2689597-1	1989	Luteinizing hormone-releasing hormone (LHRH), a hypothalamic neurohormone, forms a complex with Zn ions in solution.	Zinc	96-98	gonadotropin releasing hormone 1	Homo sapiens	0-37
2689597-1	1989	Luteinizing hormone-releasing hormone (LHRH), a hypothalamic neurohormone, forms a complex with Zn ions in solution.	Zinc	96-98	gonadotropin releasing hormone 1	Homo sapiens	39-43
2689597-2	1989	In order to explain the structure of this complex, the stability constants of Zn(II) complexes of LHRH and also pyroglutamyl-histidine-methylester, N-acetyl-histamine, and N-acetyl-histidine were established with the use of potentiometric technique.	Zinc	78-84	gonadotropin releasing hormone 1	Homo sapiens	98-102
2689597-3	1989	The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond.	Zinc	83-89	gonadotropin releasing hormone 1	Homo sapiens	93-97
33999622-7	2021	A spin-filter ICP-MS experiment to quantify the metal that is bound to the ZF after metal exchange was performed, and it was determined that Cd exchanges with Zn in Zn2-TTP-2D and that Zn exchanges with Cd in Cd2-TTP-2D.	Zinc	159-161	ZFP36 ring finger protein	Homo sapiens	169-172
33999622-10	2021	These data show that Cd can exchange with Zn in TTP without affecting function.	Zinc	42-44	ZFP36 ring finger protein	Homo sapiens	48-51
2693940-6	1989	While multiple copies of the ZRC1 gene enable yeast cells to grow in the presence of 40 mM Zn2+, a level at which wild-type cells cannot survive, the disruption of the chromosomal ZRC1 locus, though not a lethal event, makes cells more sensitive to zinc ions than are wild-type cells.	Zinc	91-95	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	29-33
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	Zinc	19-23	solute carrier family 39 member 8	Homo sapiens	95-99
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	Zinc	19-23	solute carrier family 39 member 14	Homo sapiens	104-109
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	Zinc	19-21	solute carrier family 39 member 8	Homo sapiens	95-99
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	Zinc	19-21	solute carrier family 39 member 14	Homo sapiens	104-109
3715922-8	1986	In conditions showing a slight increase in liver Ca and a significant decrease in serum Ca by synthetic [Asu1,7] eel calcitonin (CT) injection, gel filtration of liver cytosol obtained from CT-treated rats showed a higher content of Zn and a higher radioactivity of [3H]cystine than that from control injection.	Zinc	233-235	calcitonin-related polypeptide alpha	Rattus norvegicus	190-192
3715922-9	1986	This suggests that CT causes an increase in liver Ca and results in induction of MT-like protein containing Zn by Ca.	Zinc	108-110	calcitonin-related polypeptide alpha	Rattus norvegicus	19-21
2788596-2	1989	Nuclease which degrades chromatin produces in vivo fragments of nucleosomal size; the double-strand breaks appear as the result of the accumulation of single-strand breaks with 3"-OH ends; the nuclease is inhibited by Zn2+ and DTNB and its activity is depressed by cycloheximide pretreatment.	Zinc	218-222	dystrobrevin beta	Homo sapiens	227-231
3931671-5	1985	From the difference in bis-ANS affinity between apo-alpha-LA and Ca(II)-alpha-LA, we demonstrated that Zn(II) and Al(III) were able to "lock" the protein into a new "apo-like" conformation, which was similar to, but not identical with, the apo conformation.	Zinc	103-109	carbonic anhydrase 2	Bos taurus	65-71
4039320-1	1985	The autophosphorylation reaction responsible for conversion of insulin receptor (from human placenta) to an active tyrosyl-protein kinase was shown to be inhibited by Zn2+ and other divalent metal ions.	Zinc	167-171	insulin receptor	Homo sapiens	63-79
4039320-3	1985	Autophosphorylation of insulin receptor was almost completely blocked by 10 microM Zn2+.	Zinc	83-87	insulin receptor	Homo sapiens	23-39
4039320-8	1985	Zn2+ was also observed to inhibit phosphotyrosyl-protein phosphatase activity present in preparations of partially purified insulin receptor.	Zinc	0-4	insulin receptor	Homo sapiens	124-140
4039320-9	1985	These inhibitory effects of Zn2+ should be considered in the design of protocols for the isolation and handling of insulin receptor and possibly other tyrosine kinases.	Zinc	28-32	insulin receptor	Homo sapiens	115-131
33524916-0	2021	Electron energy loss spectroscopy and first-principles study of GaN via Zn doping.	Zinc	72-74	gigaxonin	Homo sapiens	64-67
33524916-1	2021	The electronic structure of GaN and GaN:Zn was investigated by electron energy loss spectroscopy and first-principles calculations.	Zinc	40-42	gigaxonin	Homo sapiens	36-39
33524916-5	2021	A core-hole effect is believed to be significant for simulation of the N K-edge for both GaN and GaN:Zn.	Zinc	101-103	gigaxonin	Homo sapiens	97-100
33750840-6	2021	Zn2+ specifically induced oligomerization of both MBP-CRISP1 and MBP-CRISP1DeltaC in vitro.	Zinc	0-4	myelin basic protein	Homo sapiens	50-53
2620574-2	1989	Mean maternal serum values of Ca, Mg, Cu and Zn in the PIH group were 2.460 mmol/L, 0.839 mmol/L, 35.094 mol/L and 8.408 mumol/L,respectively and were compared with the corresponding Values of 2.765 mmol/L, 0.834 mmol/L, 31.486 mumol/L, and 9.657 mumol/L in the controls.	Zinc	45-47	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	55-58
3835805-1	1985	In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates.	Zinc	80-82	monoamine oxidase A	Rattus norvegicus	133-150
3835805-1	1985	In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates.	Zinc	80-82	monoamine oxidase A	Rattus norvegicus	152-155
2620574-3	1989	The Ca and Zn levels were lower and Cu higher in the PIH group (P less than 0.05 or P less than 0.01).	Zinc	11-13	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	53-56
33750840-6	2021	Zn2+ specifically induced oligomerization of both MBP-CRISP1 and MBP-CRISP1DeltaC in vitro.	Zinc	0-4	myelin basic protein	Homo sapiens	65-68
2497463-0	1989	Structure and function of the Zn(II) binding site within the DNA-binding domain of the GAL4 transcription factor.	Zinc	30-36	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	87-91
33750840-8	2021	Furthermore, MBP-CRISP1 and MBP-CRISP1DeltaC oligomers dissociated into monomers upon Zn2+ removal by EDTA.	Zinc	86-90	myelin basic protein	Homo sapiens	13-16
6748376-5	1984	The hepatic concentration of Zn2+ tended to be increased by the Cd2+ challenge and was increased further by pretreatment.	Zinc	29-33	CD2 antigen	Mus musculus	64-67
6658820-2	1983	This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supporting the hypothesis that the effect of Zn administration on bone may be mediated by parathyroid hormone.	Zinc	179-181	calcitonin-related polypeptide alpha	Rattus norvegicus	42-52
2497463-4	1989	The homogeneous GAL4-(149*) protein contains 1-1.5 moles of Zn(II) per mole of protein.	Zinc	60-62	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	16-20
2497463-7	1989	The GAL4(149*) apoprotein can be reconstituted with Zn(II), Cd(II), or Co(II) with restoration of specific DNA binding.	Zinc	52-58	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	4-8
6615896-3	1983	A significant increase of Ca2+, Mg2+ and Zn2+ levels has been established in ascitic H3, H2B and H1 fractions.	Zinc	41-45	histocompatibility 1	Mus musculus	89-99
32066337-4	2021	The results showed two conditions which appear to be essential that peptides presented ACE inhibition capacity: i) to interact with Zn2+ coordinated residues, such as His383, His387, and Glu411, by short hydrogen bonds, for peptides with high inhibitory capacity in vitro, as ALNEINQFYQK (IACE = 80.7%), NAVPITPTLNR (IACE = 80.7%), and FALPQYLK (IACE = 79.0%); or interact by electrostatic and hydrophobic interactions with the same residues, for peptides with intermediate inhibition capacity in vitro, as HQGLPQEVLNENLLR (IACE = 49.2%), FFVAPFPEVFGK (IACE = 47.8%) and YLGYLEQLLR (IACE = 47.8%); ii) to interact with the S1 active site residues (Ala354, Glu384, and Tyr523) by hydrogen bonds.	Zinc	132-136	angiotensin I converting enzyme	Bos taurus	87-90
2497463-12	1989	The binding of Zn(II), Cd(II), and, to a lesser extent, Co(II) to GAL4(149*) apoprotein protects the protein from proteolysis by trypsin, which produces a 13-kDa DNA-binding core.	Zinc	15-21	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	66-70
2538151-9	1989	Except for Zn2+, ranking for their activating potency of MLCK, the analogs can be arranged in a similar order.	Zinc	11-15	myosin light chain kinase 3	Homo sapiens	57-61
32927449-3	2021	The experimental investigations show that Zn occupies Ni-site and that the films are grown with an in-plane compressive strain on LAO.	Zinc	42-44	interleukin 4 induced 1	Homo sapiens	130-133
7225331-4	1981	Zn2+ or Co2+ induces MTP + GTP to form sheets with more than 13 protofilaments.	Zinc	0-4	microsomal triglyceride transfer protein	Bos taurus	21-24
7225331-8	1981	MTP incubated with Zn2+ and CrGTP assembled into sheets, shorter than but similar to those induced by Zn2+ + GTP.	Zinc	19-23	microsomal triglyceride transfer protein	Bos taurus	0-3
7225331-10	1981	Zn2+ induced taxol-treated MTP to form sheets.	Zinc	0-4	microsomal triglyceride transfer protein	Bos taurus	27-30
3191138-2	1988	The Cu2+ bound on the surface of the myoglobin molecule are efficient quenchers of the excited electron state of Zn-myoglobin.	Zinc	113-115	myoglobin	Physeter catodon	37-46
377069-3	1978	Kinetic characteristics, and inhibition by antibodies and Zn++, showed that the residual activity was "authentic" acid maltase.	Zinc	58-62	alpha glucosidase	Homo sapiens	114-126
4279408-3	1974	Zn(++) and Na(+) strongly inhibit the increase in Ca(++) conductance obtained with solubilized Ca(++) + Mg(++)-dependent adenosinetriphosphatase.	Zinc	0-6	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	121-144
5378378-12	1969	The soluble Zn(2+)-activated acid phosphatase activity appears to be thermally stabilized by the treatment with Triton X-100 or bovine serum albumin.	Zinc	12-14	albumin	Gallus gallus	135-148
33151037-4	2021	The CS-Zn(II) MNs combined the structure characteristic of MNs with the antibacterial properties of CS and Zn2+ .	Zinc	107-111	citrate synthase	Homo sapiens	4-6
33151037-7	2021	What is more, the synergistic effect of CS and Zn2+ make the CS-Zn(II) MNs obtain excellent antibiofilm properties.	Zinc	47-51	citrate synthase	Homo sapiens	61-63
33151037-8	2021	Counting the colony forming units and bacterial live/dead staining tests confirmed the fascinating antibacterial abilities (up to 100% inhibition) and biofilm eradication properties, respectively, of the CS-Zn(II) MNs.	Zinc	207-209	citrate synthase	Homo sapiens	204-206
33151037-11	2021	These results indicate that the CS-Zn(II) MNs are promising method for bacterial biofilm eradication.	Zinc	35-37	citrate synthase	Homo sapiens	32-34
33852199-4	2021	The Zn@CoNiP/rGO anode obtained by zinc-ion activation and a biomass-derived porous carbon cathode (PC) were assembled into an aqueous ZIC (CNP-ZIC) in 2 m ZnSO4 .	Zinc	4-6	Zic family member 1	Homo sapiens	135-138
33852199-4	2021	The Zn@CoNiP/rGO anode obtained by zinc-ion activation and a biomass-derived porous carbon cathode (PC) were assembled into an aqueous ZIC (CNP-ZIC) in 2 m ZnSO4 .	Zinc	4-6	Zic family member 1	Homo sapiens	140-147
33999622-5	2021	We sought to determine whether Cd exchanges with Zn in the TTP active site and measure the effect of RNA binding on this exchange.	Zinc	49-51	ZFP36 ring finger protein	Homo sapiens	59-62
33962015-3	2021	In this, the first study of ZAC in Xenopus oocytes by TEVC electrophysiology, ZACThr128 and ZACAla128 exhibited largely comparable pharmacological and signalling characteristics, but interestingly the Zn2+- and H+-evoked current amplitudes in ZACAla128-oocytes were dramatically smaller than in ZACThr128-oocytes.	Zinc	201-205	zinc activated ion channel	Homo sapiens	28-31
33723799-6	2021	Zinc (Zn) trace element is thought to be able to modulate the induction of AhR-responsive genes in endothelial cells.	Zinc	6-8	aryl hydrocarbon receptor	Homo sapiens	75-78
33723799-7	2021	Although it is emphasized that trace elements are related with gastritis, relationship between Zn and AhR is not fully known, especially in chronic gastritis accompanied by H. pylori infection.	Zinc	95-97	aryl hydrocarbon receptor	Homo sapiens	102-105
33723799-13	2021	When AhR and Zn serum levels were compared in H. pylori positive and negative chronic gastritis patients, it was found that AhR serum level of H. pylori positive chronic gastritis patients increased but it was not statistically significant (p = 0.595).	Zinc	13-15	aryl hydrocarbon receptor	Homo sapiens	124-127
33604973-3	2021	Then, a highly electronically insulating (0.11 mS cm-1 ) but highly Zn2+ ion conductive (80.2 mS cm-1 ) ZnF2 solid ion conductor with high Zn2+ transfer number (0.65) is constructed to isolate Zn metal from liquid electrolyte, which not only prohibits over 99.2% parasitic hydrogen evolution but also guides uniform Zn electrodeposition.	Zinc	68-72	zinc finger protein 2	Homo sapiens	104-108
33604973-3	2021	Then, a highly electronically insulating (0.11 mS cm-1 ) but highly Zn2+ ion conductive (80.2 mS cm-1 ) ZnF2 solid ion conductor with high Zn2+ transfer number (0.65) is constructed to isolate Zn metal from liquid electrolyte, which not only prohibits over 99.2% parasitic hydrogen evolution but also guides uniform Zn electrodeposition.	Zinc	139-143	zinc finger protein 2	Homo sapiens	104-108
33604973-3	2021	Then, a highly electronically insulating (0.11 mS cm-1 ) but highly Zn2+ ion conductive (80.2 mS cm-1 ) ZnF2 solid ion conductor with high Zn2+ transfer number (0.65) is constructed to isolate Zn metal from liquid electrolyte, which not only prohibits over 99.2% parasitic hydrogen evolution but also guides uniform Zn electrodeposition.	Zinc	68-70	zinc finger protein 2	Homo sapiens	104-108
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Zinc	27-29	zinc finger protein 2	Homo sapiens	30-34
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Zinc	27-29	zinc finger protein 2	Homo sapiens	40-44
33604973-5	2021	Encouragingly, a high-areal-capacity Zn@ZnF2 //MnO2 ( 3.2 mAh cm-2 ) full cell only produces maximum hydrogen flux of 0.06 mmol h-1 cm-2 (0.78% of the Zn//Zn cell) at the fully charging state.	Zinc	37-39	zinc finger protein 2	Homo sapiens	40-44
33604973-7	2021	In light of the superior Zn@ZnF2 anode, the high-areal-capacity aqueous Zn@ZnF2 //MnO2 batteries ( 3.2 mAh cm-2 ) shows remarkable cycling stability over 1000 cycles with 93.63% capacity retained at  100% Coulombic efficiency.	Zinc	25-27	zinc finger protein 2	Homo sapiens	28-32
33604973-7	2021	In light of the superior Zn@ZnF2 anode, the high-areal-capacity aqueous Zn@ZnF2 //MnO2 batteries ( 3.2 mAh cm-2 ) shows remarkable cycling stability over 1000 cycles with 93.63% capacity retained at  100% Coulombic efficiency.	Zinc	25-27	zinc finger protein 2	Homo sapiens	75-79
33604973-7	2021	In light of the superior Zn@ZnF2 anode, the high-areal-capacity aqueous Zn@ZnF2 //MnO2 batteries ( 3.2 mAh cm-2 ) shows remarkable cycling stability over 1000 cycles with 93.63% capacity retained at  100% Coulombic efficiency.	Zinc	28-30	zinc finger protein 2	Homo sapiens	75-79
33196999-5	2021	The results showed that the increment in Zn/Al molar ratio reduced the BET area and the pure Al2O3 powder possessed the highest BET area (235.4 m2 g-1).	Zinc	41-43	delta/notch like EGF repeat containing	Homo sapiens	71-74
33410087-1	2021	Monoiodo- and dibromsubstituted dipyrromethenes HL1 - HL3 were described as a highly sensitive and selective <<Off-On>> fluorescent chemosensor for Zn2+ based on the chelation-enhanced fluorescence (CHEF) effect.	Zinc	148-152	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	54-57
33410087-2	2021	Soordination reactions of HL1 - HL3 with Zn2+ cations are accompanied by a significant (124 to 215-fold) increase in fluorescence intensity against the background of other metal ions in the binary propanol-1/cyclohexane mixture (1:30).	Zinc	41-45	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	32-35
33410087-3	2021	The fluorometric detection limit of Zn2+ ions using HL1 - HL3 sensors is from 3.0 10-8 to 3.3 10-9 mol/L.	Zinc	36-40	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	58-61
33410087-5	2021	Complexation reactions are accompanied by a visual change in the color of the solution from yellow-orange to pink-raspberry so that the HL1 - HL3 ligands can also be used as a <<naked-eye>> indicators of the presence of Zn2+ ions.	Zinc	220-224	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	142-145
33670903-0	2021	Formation, Structure and Magnetic Properties of MFe2O4@SiO2 (M = Co, Mn, Zn, Ni, Cu) Nanocomposites.	Zinc	73-75	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	48-52
33537316-10	2020	In the structure of the EFhd1 core domain, two Zn2+ ions were observed at the interface of the crystal contact, suggesting the possibility of Zn2+-mediated multimerization.	Zinc	47-51	EF-hand domain family member D1	Homo sapiens	24-29
33537316-10	2020	In the structure of the EFhd1 core domain, two Zn2+ ions were observed at the interface of the crystal contact, suggesting the possibility of Zn2+-mediated multimerization.	Zinc	142-146	EF-hand domain family member D1	Homo sapiens	24-29
33236142-4	2021	Thus, the present study models potential Zn binding to RdRp and the 3CLpro.	Zinc	41-43	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	55-59
33188635-3	2021	Results point to the derivative HL2 as the best chemosensor for Zn2+ ions because of its comparatively higher sensitivity.	Zinc	64-68	intelectin 2	Homo sapiens	32-35
33188635-5	2021	Moreover, HL2 was the only derivative to emit fluorescence in the presence of Zn2+ ions, attributable to PET inhibition and bond isomerization promoted by coordination with this metal.	Zinc	78-82	intelectin 2	Homo sapiens	10-13
33188635-6	2021	LOD, LOQ, and binding constant values for HL2 + Zn2+ were 0.43 mumol.l-1, 0.93 mumol.l-1, and 5.04 x 1012 l.mol-1, respectively.	Zinc	48-52	intelectin 2	Homo sapiens	42-45
33340065-3	2021	The complexation of Zn2+, Fe2+, Mg2+ with 1:1 and 2:1 stoichiometry leads to characteristic optical responses that depend significantly on the employed solvents, thus allowing for the fluorimetric identification and detection of particular metal cations in a matrix-based pattern analysis or by fluorimetric titrations.	Zinc	20-24	mucin 7, secreted	Homo sapiens	32-51
32987107-0	2020	Comparison of HIV-1 Gag and NCp7 in their selectivity for package signal, affinity for stem-loop 3, and Zn2+ content.	Zinc	104-108	Pr55(Gag)	Human immunodeficiency virus 1	20-23
32987107-6	2020	Moreover, Gag contained two Zn2+ whereas NCp7 contained one.	Zinc	28-32	Pr55(Gag)	Human immunodeficiency virus 1	10-13
32987107-9	2020	These results indicated that Zn2+ coordination of Gag is critical for Psi-binding and selection.	Zinc	29-33	Pr55(Gag)	Human immunodeficiency virus 1	50-53
32987107-10	2020	Removal of Zn2+from the first zinc-finger motif during or after Gag cleavage to generate mature NCp7 might serve as a switch to regulate the functions of Gag NC domain and mature NCp7.	Zinc	11-15	Pr55(Gag)	Human immunodeficiency virus 1	64-67
32987107-10	2020	Removal of Zn2+from the first zinc-finger motif during or after Gag cleavage to generate mature NCp7 might serve as a switch to regulate the functions of Gag NC domain and mature NCp7.	Zinc	11-15	Pr55(Gag)	Human immunodeficiency virus 1	154-157
32987107-11	2020	Our study will be helpful to elucidate the important roles that Zn2+ plays in the viral life cycle, and may benefit further investigations of the function of HIV-1 Gag and NCp7.	Zinc	64-68	Pr55(Gag)	Human immunodeficiency virus 1	164-167
33026032-4	2020	Sci., 2017, 124, 35-45] revealed a significant transfer of electrons from Mg to Zn atoms in these nanoalloys; so the main novelty in the present work is the development of an improved EP, termed Coulomb-corrected-Gupta potential, which incorporates an explicit charge-transfer correction term onto a metallic Gupta potential description.	Zinc	80-82	epiregulin	Homo sapiens	184-186
32902579-3	2020	When we replaced valine with histidine at position 116 in the external vestibule of hHV1, current was potently inhibited by externally applied Zn2+ in a construct lacking the two His that bind Zn2+ in WT channels.	Zinc	143-147	hydrogen voltage gated channel 1	Homo sapiens	84-88
32902579-3	2020	When we replaced valine with histidine at position 116 in the external vestibule of hHV1, current was potently inhibited by externally applied Zn2+ in a construct lacking the two His that bind Zn2+ in WT channels.	Zinc	193-197	hydrogen voltage gated channel 1	Homo sapiens	84-88
32902579-10	2020	This behavior in turn suggests that the affinity for Zn2+ is greater in the closed state of hHV1.	Zinc	53-57	hydrogen voltage gated channel 1	Homo sapiens	92-96
32910187-0	2020	Zn2+ to probe voltage-gated proton (Hv1) channels.	Zinc	0-4	hydrogen voltage gated channel 1	Homo sapiens	36-39
32559765-3	2020	We reveal the FXII fibronectin type II domain (FnII) binds gC1qR in a Zn2+ dependent fashion and determined the complex crystal structure.	Zinc	70-74	complement C1q binding protein	Homo sapiens	59-64
32559765-5	2020	gC1qR residues Asp185 and His187 coordinate a Zn2+ adjacent to the FXII binding site and a comparison with the ligand free gC1qR crystal structure reveals the anionic G1-loop becomes ordered upon FXIIFnII binding.	Zinc	46-50	complement C1q binding protein	Homo sapiens	0-5
32559765-7	2020	Mutagenesis coupled with SPR demonstrate the gC1qR Zn2+ site contributes to FXII binding and plasma based assays reveal gC1qR stimulates coagulation in a FXII-dependent manner.	Zinc	51-55	sepiapterin reductase	Homo sapiens	25-28
32559765-7	2020	Mutagenesis coupled with SPR demonstrate the gC1qR Zn2+ site contributes to FXII binding and plasma based assays reveal gC1qR stimulates coagulation in a FXII-dependent manner.	Zinc	51-55	complement C1q binding protein	Homo sapiens	45-50
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	55-57	reticulon 3	Homo sapiens	58-61
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	58-61
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	70-73
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	70-73
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	58-61
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	70-73
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Zinc	129-131	reticulon 3	Homo sapiens	70-73
32687683-0	2020	An Ag2 S@ZnS coated fiber for efficient, long-life solid-phase microextraction of polycyclic aromatic hydrocarbons in water.	Zinc	9-12	angiotensin II receptor type 1	Homo sapiens	3-8
33062954-1	2020	SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys189-X-X-Cys192-X n -Cys224-X-Cys226) and a classic catalytic site (Cys111-His272-Asp286), which play key roles for viral replication and hence represent promising drug targets.	Zinc	65-67	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	41-46
33062954-2	2020	In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.	Zinc	120-122	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	137-142
32346941-7	2020	ZN also rescued the ZnT3 loss-associated reduction of neurogenesis via elevation of IGF-1 and ERK/CREB activation.	Zinc	0-2	insulin-like growth factor 1	Mus musculus	84-89
32720563-7	2021	Both GCH1 and PTPS enzymes contain Zn2+ ions in their active sites, and to accurately study their dynamic behaviors using all-atom molecular dynamics (MD) simulations, appropriate parameters that can describe their metal sites should be developed and validated.	Zinc	35-39	GTP cyclohydrolase 1	Homo sapiens	5-9
32720563-7	2021	Both GCH1 and PTPS enzymes contain Zn2+ ions in their active sites, and to accurately study their dynamic behaviors using all-atom molecular dynamics (MD) simulations, appropriate parameters that can describe their metal sites should be developed and validated.	Zinc	35-39	6-pyruvoyltetrahydropterin synthase	Homo sapiens	14-18
33046551-1	2020	Zn2+ has been shown to have a wide range of modulatory effects on neuronal AMPARs.	Zinc	0-4	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	75-81
33046551-3	2020	Here we show that Zn2+ inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependent manner, indicating a pore block mechanism.	Zinc	18-22	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	32-37
33046551-9	2020	Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors.	Zinc	36-40	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	55-61
33046551-9	2020	Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors.	Zinc	151-155	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	55-61
33046551-9	2020	Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors.	Zinc	151-155	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	165-171
32915786-7	2020	Knocking down the expression levels of ZnT1 (located mostly at the plasma membrane) and ZIP8 (present in endosomes and lysosomes) increased and decreased the ZnO-NP-induced elevation of [Zn2+]c, respectively.	Zinc	187-191	solute carrier family 39 member 8	Homo sapiens	88-92
32542960-1	2020	BACKGROUND: Although divalent zinc (Zn2+ ) is known to bind FXII and affect its sensitivity to autoactivation, little is known about the role of Zn2+ in the binding of FXII to platelets, where FXII activation is thought to occur in vivo, and the function of Zn2+ during thrombus formation following vascular injury remains poorly understood.	Zinc	36-40	coagulation factor XII (Hageman factor)	Mus musculus	60-64
32542960-1	2020	BACKGROUND: Although divalent zinc (Zn2+ ) is known to bind FXII and affect its sensitivity to autoactivation, little is known about the role of Zn2+ in the binding of FXII to platelets, where FXII activation is thought to occur in vivo, and the function of Zn2+ during thrombus formation following vascular injury remains poorly understood.	Zinc	145-149	coagulation factor XII (Hageman factor)	Mus musculus	168-172
32542960-1	2020	BACKGROUND: Although divalent zinc (Zn2+ ) is known to bind FXII and affect its sensitivity to autoactivation, little is known about the role of Zn2+ in the binding of FXII to platelets, where FXII activation is thought to occur in vivo, and the function of Zn2+ during thrombus formation following vascular injury remains poorly understood.	Zinc	145-149	coagulation factor XII (Hageman factor)	Mus musculus	168-172
32542960-1	2020	BACKGROUND: Although divalent zinc (Zn2+ ) is known to bind FXII and affect its sensitivity to autoactivation, little is known about the role of Zn2+ in the binding of FXII to platelets, where FXII activation is thought to occur in vivo, and the function of Zn2+ during thrombus formation following vascular injury remains poorly understood.	Zinc	145-149	coagulation factor XII (Hageman factor)	Mus musculus	168-172
32720563-8	2021	In this study, force field parameters of the GCH1 and PTPS metal centers were generated using quantum mechanics (QM) calculations and then validated through MD simulations to ensure their accuracy in describing and maintaining the Zn2+ ion coordination environment.	Zinc	231-235	GTP cyclohydrolase 1	Homo sapiens	45-49
32720563-8	2021	In this study, force field parameters of the GCH1 and PTPS metal centers were generated using quantum mechanics (QM) calculations and then validated through MD simulations to ensure their accuracy in describing and maintaining the Zn2+ ion coordination environment.	Zinc	231-235	6-pyruvoyltetrahydropterin synthase	Homo sapiens	54-58
32542960-1	2020	BACKGROUND: Although divalent zinc (Zn2+ ) is known to bind FXII and affect its sensitivity to autoactivation, little is known about the role of Zn2+ in the binding of FXII to platelets, where FXII activation is thought to occur in vivo, and the function of Zn2+ during thrombus formation following vascular injury remains poorly understood.	Zinc	145-149	coagulation factor XII (Hageman factor)	Mus musculus	168-172
3191138-2	1988	The Cu2+ bound on the surface of the myoglobin molecule are efficient quenchers of the excited electron state of Zn-myoglobin.	Zinc	113-115	myoglobin	Physeter catodon	116-125
32542960-5	2020	RESULTS: Our data demonstrate that stimulated platelets support FXII-dependent thrombin generation and that FXII activation by platelets requires the presence of Zn2+ .	Zinc	162-166	coagulation factor XII (Hageman factor)	Mus musculus	108-112
32542960-7	2020	Using flow cytometry, we found that FXII-FITC binds to the surfaces of stimulated platelets in a specific and Zn2+ -dependent manner, whereas resting platelets demonstrated minimal binding.	Zinc	110-114	coagulation factor XII (Hageman factor)	Mus musculus	36-40
31828721-6	2020	Zn also increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3beta (GSK-3beta) phosphorylation and preserves protein kinase C isoforms.	Zinc	0-2	glycogen synthase kinase 3 beta	Homo sapiens	63-93
32542960-11	2020	CONCLUSIONS: Our results suggest a novel role for Zn2+ in the binding and activation of FXII at the platelet surface, an interaction that appears crucial to FXII-dependent thrombin generation but dispensable for hemostasis.	Zinc	50-54	coagulation factor XII (Hageman factor)	Mus musculus	88-92
2831899-4	1988	Dephosphorylation of the insulin receptor beta-subunit by rat liver membranes was inhibited by Zn+2, and stimulated by EDTA.	Zinc	95-99	insulin receptor	Rattus norvegicus	25-41
32542960-11	2020	CONCLUSIONS: Our results suggest a novel role for Zn2+ in the binding and activation of FXII at the platelet surface, an interaction that appears crucial to FXII-dependent thrombin generation but dispensable for hemostasis.	Zinc	50-54	coagulation factor XII (Hageman factor)	Mus musculus	157-161
32517868-10	2020	This study also demonstrated the opposite functions of the two zinc transporters, ZIP10 and ZnT1 as well as shedding light on the role of Zn2+ in regulation of the human hatching enzyme homologue, ovastacin, which is activated by zinc and cleaves the zona pellucida protein, ZP2, to prevent polyspermy.	Zinc	138-142	zona pellucida glycoprotein 2	Homo sapiens	275-278
31828721-6	2020	Zn also increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3beta (GSK-3beta) phosphorylation and preserves protein kinase C isoforms.	Zinc	0-2	glycogen synthase kinase 3 beta	Homo sapiens	95-104
2977004-12	1988	Hence, prostasomes contained ATPase as well as aminopeptidase activities both of which being dependent upon Zn2+.	Zinc	108-112	dynein axonemal heavy chain 8	Homo sapiens	29-35
32319538-6	2020	Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2.	Zinc	38-42	angiotensin converting enzyme 2	Homo sapiens	72-103
32319538-6	2020	Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2.	Zinc	38-42	angiotensin converting enzyme 2	Homo sapiens	105-109
32584489-5	2020	On the other hand, integrating Co, Mn, and Zn turns Li2 S into a prelithiation agent, forming metal sulfides rather than S8 after the full charge.	Zinc	43-45	ATP binding cassette subfamily A member 12	Homo sapiens	52-55
3567680-2	1987	Feeding broilers Zn bacitracin significantly improved growth rate and food conversion, and increased shank pigmentation.	Zinc	17-19	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	101-106
33045951-2	2020	Zn2+ is a differential regulator of the mitochondrial enzyme lipoamide dehydrogenase (LADH) at physiological concentrations (Ka = 0.1 microM free zinc), inhibiting lipoamide and accelerating NADH dehydrogenase activities.	Zinc	0-4	dihydrolipoamide dehydrogenase	Sus scrofa	61-84
3544718-7	1986	Similar to PPCE characterized from other sites, vascular PPCE was stabilized and activated by dithiothreitol and EDTA, and inhibited by DFP, p-chloromercuriphenyl sulfonic acid, L-1-tosylamido-2-phenylethylchloromethyl ketone, Cu++, Ca++, and Zn++.	Zinc	243-247	prolyl endopeptidase	Homo sapiens	11-15
33045951-2	2020	Zn2+ is a differential regulator of the mitochondrial enzyme lipoamide dehydrogenase (LADH) at physiological concentrations (Ka = 0.1 microM free zinc), inhibiting lipoamide and accelerating NADH dehydrogenase activities.	Zinc	0-4	dihydrolipoamide dehydrogenase	Sus scrofa	86-90
33045951-3	2020	These differential effects have been attributed to coordination of Zn2+ by LADH active-site cysteines.	Zinc	67-71	dihydrolipoamide dehydrogenase	Sus scrofa	75-79
33045951-5	2020	Anaerobic stopped-flow experiments show that two-electron reduced LADH is 15-25-fold less active towards DCPIP reduction than four-electron reduced enzyme, or Zn2+-modified reduced LADH (the corresponding values of the rate constants are (6.5 +- 1.5) x 103 M-1 s-1, (9 +- 2) x 104 M-1 s-1, and (1.6 +- 0.5) x 105 M-1 s-1, respectively).	Zinc	159-163	dihydrolipoamide dehydrogenase	Sus scrofa	66-70
33045951-5	2020	Anaerobic stopped-flow experiments show that two-electron reduced LADH is 15-25-fold less active towards DCPIP reduction than four-electron reduced enzyme, or Zn2+-modified reduced LADH (the corresponding values of the rate constants are (6.5 +- 1.5) x 103 M-1 s-1, (9 +- 2) x 104 M-1 s-1, and (1.6 +- 0.5) x 105 M-1 s-1, respectively).	Zinc	159-163	dihydrolipoamide dehydrogenase	Sus scrofa	181-185
33045951-7	2020	This implies that the two-electron reduced form of LADH, prevalent at low NADH levels, is a poor two-electron donor compared to the four-electron reduced or Zn2+-modified reduced LADH forms.	Zinc	157-161	dihydrolipoamide dehydrogenase	Sus scrofa	51-55
33045951-7	2020	This implies that the two-electron reduced form of LADH, prevalent at low NADH levels, is a poor two-electron donor compared to the four-electron reduced or Zn2+-modified reduced LADH forms.	Zinc	157-161	dihydrolipoamide dehydrogenase	Sus scrofa	179-183
31968444-1	2020	Thermal properties and microstructure of Al-4 wt.% Zn-2 wt.% Cu-x (x = 2 wt%.	Zinc	51-53	cut like homeobox 1	Homo sapiens	61-65
32045805-5	2020	Benefiting from the excellent electrical conductivity and high specific surface area of the NHC which is superior to other carbon material and the favorable band gap of ZnIn2S4 makes ZIS-NHC has superior light-driven photocatalytic efficiency.	Zinc	169-176	zinc finger RANBP2-type containing 2	Homo sapiens	183-186
3544718-7	1986	Similar to PPCE characterized from other sites, vascular PPCE was stabilized and activated by dithiothreitol and EDTA, and inhibited by DFP, p-chloromercuriphenyl sulfonic acid, L-1-tosylamido-2-phenylethylchloromethyl ketone, Cu++, Ca++, and Zn++.	Zinc	243-247	prolyl endopeptidase	Homo sapiens	57-61
32710088-6	2020	Alanine substitutions of unique D2L5 loop cysteines of LCaV3 channels increases relative monovalent ion current sizes and increases the potency of Zn2+ and Ni2+ block by ~ 50x and ~ 10x in loop cysteine mutated channels respectively, acquiring characteristics of the high affinity block of CaV3.2 channels, including the loss of the slowing of inactivation kinetics during Zn2+ block.	Zinc	147-151	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	290-296
3935753-7	1985	At pH 8.0 the buffer-free exchange of Pb2+ by Zn2+ is found to be consistent with a second-order process with an effective beta = (95 +/- 7) M-1 sec-1.	Zinc	46-50	galactoside 2-alpha-L-fucosyltransferase SEC1	Bos taurus	145-150
32710088-6	2020	Alanine substitutions of unique D2L5 loop cysteines of LCaV3 channels increases relative monovalent ion current sizes and increases the potency of Zn2+ and Ni2+ block by ~ 50x and ~ 10x in loop cysteine mutated channels respectively, acquiring characteristics of the high affinity block of CaV3.2 channels, including the loss of the slowing of inactivation kinetics during Zn2+ block.	Zinc	373-377	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	290-296
32353602-6	2020	Zn was found to regulate the expression of peroxidases (peroxiredoxin-1, peroxiredoxin-5, peroxiredoxin-6) to relieve AFB1-induced oxidative stress.	Zinc	0-2	peroxiredoxin 6	Homo sapiens	90-105
32353602-8	2020	In addition, AFB1 reduced intracellular ATP levels, whereas Zn supplementation boosted ATP levels and maintained homeostasis and a steady state of cellular energy metabolism by modulating AMPK-ACC phosphorylation levels, while many zinc finger proteins changed after AFB1 treatment.	Zinc	60-62	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	188-192
3977317-8	1985	The effects of calmodulin and dialysis on protein methylation are cation-dependent and substrate-specific; methylation of the Mr 29,000 was supported by Mn2+, Ca2+, and Co2+, and to a lesser degree by Mg2+, Ni2+, and Zn2+.	Zinc	217-221	calmodulin 1	Rattus norvegicus	15-25
32609136-3	2020	To bypass the sluggish movement of Mg2+ ions inside the cathode and utilize the full advantage of the Mg anode, a Mg2+/Li+ hybrid ion battery (MLIB) is introduced here with rationally designed porous Ni/Zn co-doped CoS2@C spheres as the cathode material.	Zinc	203-205	mucin 7, secreted	Homo sapiens	114-117
32609136-4	2020	The Ni/Zn-CoS2@C cathode with high porosity and electrical conductivity showed an appreciable specific capacity of 158 mA h g-1 at 20 mA g-1 for MIBs, which was significantly boosted up to 667 mA h g-1 at a current density of 50 mA g-1 by employing Mg2+/Li+ hybrid electrolytes.	Zinc	7-9	mucin 7, secreted	Homo sapiens	249-252
31968444-6	2020	The thermal conductivity with temperature and composition of as-extruded Al-4 wt.% Zn-2 wt.% Cu-x alloys decreases with adding 2 wt.% Mg, 2 wt.% Sn contents from 190.925 and 196.451 W/mK but thermal properties of addition of 0.7 wt.% Mg-0.7 wt.% Sn-0.7 wt.% Ca element slightly reduced from 222.32 to 180.775 W/mK.	Zinc	83-85	cut like homeobox 1	Homo sapiens	93-97
31951514-1	2020	The present work addresses the effect of excess levels of ZnCl2 and CuSO4 in the growth medium on the conjugative transfer of plasmids carrying the antibiotic resistance gene blaCMY-2 from extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.	Zinc	58-63	beta-lactamase	Escherichia coli	207-221
31427180-5	2020	Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls.	Zinc	7-9	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	44-47
31427180-5	2020	Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls.	Zinc	21-23	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	44-47
6439575-6	1984	ACAT activity of EDTA-treated microsomes compared to the control was enhanced rather than suppressed after the addition of Ca2+, Mg2+, and Ba2+ ions whereas other metal ions (Co2+, Cu2+, Zn2+) almost completely suppressed ACAT activity in both the EDTA-treated and buffer-treated microsomes.	Zinc	187-191	sterol O-acyltransferase 1	Homo sapiens	0-4
32064725-6	2020	KEY RESULTS: TRPA1 stimulation with either CIN-Zn or CIT reduced time to laryngeal vestibule closure (CIN-Zn P = .002, CIT P = .023) and upper esophageal sphincter opening (CIN-Zn P = .007, CIT P = .035).	Zinc	47-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	13-18
32064725-6	2020	KEY RESULTS: TRPA1 stimulation with either CIN-Zn or CIT reduced time to laryngeal vestibule closure (CIN-Zn P = .002, CIT P = .023) and upper esophageal sphincter opening (CIN-Zn P = .007, CIT P = .035).	Zinc	106-108	transient receptor potential cation channel subfamily A member 1	Homo sapiens	13-18
6328403-2	1984	Zn2+ at concentrations of 10(-6) to 10(-4) M enhanced the hCG-stimulated production of cyclic AMP and testosterone, but only in the presence of Ca2+ X [125I]hCG binding to rat testicular tissue was not affected by Zn2+ X Cu2+, Ni2+, Co2+, and Mn2+ did not increase cyclic AMP or testosterone production in concentrations of 10(-7) to 10(-3) M and even inhibited them at a high concentration (10(-2) M).	Zinc	0-4	hypertrichosis 2 (generalised, congenital)	Homo sapiens	58-61
32528485-3	2020	In Arabidopsis, the plasma membrane Heavy Metal ATPase 4 (HMA4) transporter mediates Cd xylem loading for export to shoots, in addition to zinc (Zn).	Zinc	145-147	heavy metal atpase 4	Arabidopsis thaliana	58-62
32528485-4	2020	A recent study showed that di-Cys motifs present in the HMA4 C-terminal extension (AtHMA4c) are essential for high-affinity Zn binding and transport in planta.	Zinc	124-126	heavy metal atpase 4	Arabidopsis thaliana	56-60
32061854-0	2020	Characterization of Cu2+ and Zn2+ binding sites in SUMO1 and its impact on protein stability.	Zinc	29-33	small ubiquitin like modifier 1	Homo sapiens	51-56
32061854-4	2020	Between Cu2+ and Zn2+, the former binds more strongly with SUMO1 as determined using fluorescence spectroscopy.	Zinc	17-21	small ubiquitin like modifier 1	Homo sapiens	59-64
32061854-7	2020	Cu2+ induced paramagnetic quenching and Zn2+ induced chemical shift perturbation of 15N-1H cross-peaks were used to identify their respective binding sites in SUMO1.	Zinc	40-43	small ubiquitin like modifier 1	Homo sapiens	159-164
6328403-2	1984	Zn2+ at concentrations of 10(-6) to 10(-4) M enhanced the hCG-stimulated production of cyclic AMP and testosterone, but only in the presence of Ca2+ X [125I]hCG binding to rat testicular tissue was not affected by Zn2+ X Cu2+, Ni2+, Co2+, and Mn2+ did not increase cyclic AMP or testosterone production in concentrations of 10(-7) to 10(-3) M and even inhibited them at a high concentration (10(-2) M).	Zinc	0-4	hypertrichosis 2 (generalised, congenital)	Homo sapiens	157-160
6528814-1	1984	In in vivo and in vitro experiments the effects of some heavy metal salts (Cu, Co, Cd, Pb, Ni, Zn, Hg, As, Bi and Sn) on rat liver and brain mitochondrial monoamine oxidase (MAO) activity was studied using three different substrates (tyramine, 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (2-PEA).	Zinc	95-97	monoamine oxidase A	Rattus norvegicus	155-172
32061854-9	2020	Our findings provide structural insights into the SUMO1-Cu2+/Zn2+ interaction, and its impact on aggregation of SUMO1 which might affect its ability to modify functions of target proteins.	Zinc	61-64	small ubiquitin like modifier 1	Homo sapiens	50-55
6528814-2	1984	It was established that some of the metals (Cu, Cd, Bi) inhibited MAO activity both in vivo and in vitro experiments, others like Ni, Zn, As and Sn inhibited it only in vivo while Hg exerted inhibitory action only in vitro.	Zinc	134-136	monoamine oxidase A	Rattus norvegicus	66-69
32068056-2	2020	In this research, the thiourea-modified magnetic ZnO/nanocellulose composite (TZFNC) with high adsorption capacity and separation efficiency for Pb(II) was prepared successfully, and its physicochemical properties were characterized via XRD, SEM, TEM, AFM, BET, FTIR, XPS, EDAX, Zeta-potential and VSM, respectively.	Zinc	49-52	delta/notch like EGF repeat containing	Homo sapiens	257-260
6429557-5	1984	The enzyme was inhibited by Zn2+, phosphate, fluoride, EDTA and by treatment with neuraminidase.	Zinc	28-32	neuraminidase 1	Homo sapiens	82-95
32162226-4	2020	Thus, this study aimed to analyze the capacity of Cd and Zn to induce VTG production in Danio rerio males and determine whether the histochemical labeling method is efficient to study estrogenic effects in this species.	Zinc	57-59	vitellogenin	Danio rerio	70-73
32162226-7	2020	After analyzes, it was possible observed that Cd and Zn are capable of inducing VTG production in D. rerio males and that the histochemistry method is efficient for detection of estrogenic effects in this species.	Zinc	53-55	vitellogenin	Danio rerio	80-83
32023491-6	2020	Our data demonstrate that MOE disruption caused by nasal exposure to ZnSO4 or specific knockdown of AC3 in the MOE resulted in learning and memory impairment, and they further demonstrate that the expression of AC3 in the MOE plays a major role in learning and memory.	Zinc	69-74	adenylate cyclase 3	Mus musculus	211-214
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Zinc	188-192	mucin 7, secreted	Homo sapiens	111-114
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Zinc	188-192	mucin 7, secreted	Homo sapiens	209-212
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Zinc	333-337	mucin 7, secreted	Homo sapiens	111-114
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Zinc	333-337	mucin 7, secreted	Homo sapiens	209-212
31838350-3	2020	We display that CaF2 layer could passivate the surface traps of ZnO thin film and decrease the interfacial barrier between PC61BM and ZnO, so that electron transfer efficiency is facilitated, the recombination of electrons and holes is inhibited at the contact interface, and the series resistance is reduced.	Zinc	64-67	CCR4-NOT transcription complex subunit 8	Homo sapiens	16-20
31838350-3	2020	We display that CaF2 layer could passivate the surface traps of ZnO thin film and decrease the interfacial barrier between PC61BM and ZnO, so that electron transfer efficiency is facilitated, the recombination of electrons and holes is inhibited at the contact interface, and the series resistance is reduced.	Zinc	134-137	CCR4-NOT transcription complex subunit 8	Homo sapiens	16-20
31172426-9	2020	In addition, to verify the effect of Zn deficiency on the extracellular matrix (ECM) regulatory system, MMPs were determined by real-time PCR, and the expression in the Zn deficiency group was lower than that in the normal group and high-Zn group.	Zinc	169-171	matrix metallopeptidase 13	Mus musculus	104-108
31172426-9	2020	In addition, to verify the effect of Zn deficiency on the extracellular matrix (ECM) regulatory system, MMPs were determined by real-time PCR, and the expression in the Zn deficiency group was lower than that in the normal group and high-Zn group.	Zinc	169-171	matrix metallopeptidase 13	Mus musculus	104-108
31172426-10	2020	The MMP-2 and MMP-13 analyses showed that the expression of the high-Zn group was significantly higher than that of the normal group, indicating that Zn plays an important role in its expression.	Zinc	69-71	matrix metallopeptidase 13	Mus musculus	14-20
31931138-5	2020	Investigation of Rac and Rho in the G93A mutant, human Cu, Zn-superoxide dismutase (hSOD1) mouse model of amyotrophic lateral sclerosis (ALS), revealed that active Rac1-GTP is markedly decreased in spinal cord motor neurons of transgenic mice at disease onset and end-stage, when compared to age-matched wild type (WT) littermates.	Zinc	59-72	Rac family small GTPase 1	Mus musculus	164-168
31846878-0	2020	Cr3+ substituted Zn-Al layered double hydroxides as UV-Vis light photocatalysts for NO gas removal from the urban environment.	Zinc	17-19	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
32009135-2	2020	Then, a first new porous d-p heterometallic MOF (HMOF), namely {[PbZn(L)2] DMA H2O}n (2), was yielded via Zn(ii) ions and MOF 1 as the precursor because of the different coordination affinity of oxygen and nitrogen atoms with various metal ions.	Zinc	67-69	lysine acetyltransferase 8	Homo sapiens	29-47
32009135-2	2020	Then, a first new porous d-p heterometallic MOF (HMOF), namely {[PbZn(L)2] DMA H2O}n (2), was yielded via Zn(ii) ions and MOF 1 as the precursor because of the different coordination affinity of oxygen and nitrogen atoms with various metal ions.	Zinc	67-69	lysine acetyltransferase 8	Homo sapiens	49-53
32009135-3	2020	MOF 1 is a condensed packing motif, whereas HMOF 2 is a porous three-dimensional (3D) framework with unsaturated Pb(ii) and Zn(ii) active sites, uncoordinated carboxylate oxygen atoms and two kinds of porous channels due to the introduction of Zn(ii) ions into the framework of MOF 1, which thus endowed HMOF 2 with excellent sorption and selectivity for CO2 over CH4.	Zinc	124-126	lysine acetyltransferase 8	Homo sapiens	44-48
32009135-3	2020	MOF 1 is a condensed packing motif, whereas HMOF 2 is a porous three-dimensional (3D) framework with unsaturated Pb(ii) and Zn(ii) active sites, uncoordinated carboxylate oxygen atoms and two kinds of porous channels due to the introduction of Zn(ii) ions into the framework of MOF 1, which thus endowed HMOF 2 with excellent sorption and selectivity for CO2 over CH4.	Zinc	124-130	lysine acetyltransferase 8	Homo sapiens	44-48
31806468-9	2020	Additional Zn diet increased p62 protein level (p &lt; 0.05), decreased testicular Zn concentration (p &lt; 0.01) and down-regulated the relative mRNA expression of heme oxygenase 1 (p &lt; 0.05).	Zinc	11-13	heme oxygenase 1	Sus scrofa	165-181
31814573-4	2020	The Cu content and activity of anti- oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, were lower in the lungs of PrPC-knockout mice, suggesting that the anti-oxidative activity of PrPC is probably attributable to its function of activating SOD1 through regulating Cu content in lungs.	Zinc	57-59	prion protein	Mus musculus	118-122
31814573-4	2020	The Cu content and activity of anti- oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, were lower in the lungs of PrPC-knockout mice, suggesting that the anti-oxidative activity of PrPC is probably attributable to its function of activating SOD1 through regulating Cu content in lungs.	Zinc	57-59	prion protein	Mus musculus	185-189
31839606-6	2020	Also, binding of Zn(II) and Cu(II) by GMP-1 is weaker than the 8-hydroxyquinoline scaffold compound clioquinol previously tested in AD clinical trials.	Zinc	17-23	small ubiquitin like modifier 1	Homo sapiens	38-43
31839606-8	2020	Our data provide new insight on GMP-1 as a Zn(II) and Cu(II) specific metal chelator of moderate affinity that can be responsible for some of its neuroprotective effects observed in AD animal models.	Zinc	43-49	small ubiquitin like modifier 1	Homo sapiens	32-37
31862901-2	2019	Vacuolar storage is achieved through the action of the Zn/Cd transporter HMA3 (Heavy Metal Atpase 3).	Zinc	55-57	heavy metal atpase 3	Arabidopsis thaliana	58-99
31862901-5	2019	We hypothesize that plants sense changes in cytosolic Zn that are due to variation in HMA3 function, and respond by altering expression of genes related to Zn uptake, transport and compartmentalisation, in order to maintain Zn homeostasis.	Zinc	54-56	heavy metal atpase 3	Arabidopsis thaliana	86-90
30704300-7	2019	Additionally, the Real-Time PCR and Western blotting results for plasmid-gene (pCEP4/Cdk9) delivery showed that Zn/Al-LDH nanoparticles can be used as an effective carrier in cellular uptake and release of genes for gene therapy.	Zinc	112-114	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	85-89
31756486-5	2020	The activation of cur/SF matrix by the L-carnosine was persuading the inactivation of matrix metalloproteinase-9 (MMP-9) through its potent chelating effects of Zn2+ ions from the MMP-9 active center.	Zinc	161-165	matrix metallopeptidase 9	Mus musculus	86-112
31756486-5	2020	The activation of cur/SF matrix by the L-carnosine was persuading the inactivation of matrix metalloproteinase-9 (MMP-9) through its potent chelating effects of Zn2+ ions from the MMP-9 active center.	Zinc	161-165	matrix metallopeptidase 9	Mus musculus	114-119
31756486-5	2020	The activation of cur/SF matrix by the L-carnosine was persuading the inactivation of matrix metalloproteinase-9 (MMP-9) through its potent chelating effects of Zn2+ ions from the MMP-9 active center.	Zinc	161-165	matrix metallopeptidase 9	Mus musculus	180-185
32202034-3	2020	Herein, metal-organic framework (MOF) was constructed as front surface layer to maintain a supersaturated electrolyte layer on Zn anode.	Zinc	127-129	lysine acetyltransferase 8	Homo sapiens	8-37
32045805-3	2020	To solve this problem, we introduce a simple and efficient way to prepare a photocatalyst, ZnIn2S4 grown on nitrogen-doped hollow carbon spheres (ZIS-NHC), which is an effective catalyst that can used to reduce aqueous Cr(VI).	Zinc	91-98	zinc finger RANBP2-type containing 2	Homo sapiens	146-149
32457249-8	2020	hCP has two Zn binding sites, and gonococcal growth assays using hCP mutants deficient in one or both of the Zn binding sites revealed that TdfH exhibited a site preference during Zn piracy and utilization.	Zinc	12-14	coproporphyrinogen oxidase	Homo sapiens	0-3
32528485-9	2020	The contributions of the AtHMA4 C-terminal domain to metal transport and binding therefore differ for Zn and Cd.	Zinc	102-104	heavy metal atpase 4	Arabidopsis thaliana	25-31
32528485-10	2020	Our data suggest that it is possible to identify HMA4 variants that discriminate Zn and Cd for transport.	Zinc	81-83	heavy metal atpase 4	Arabidopsis thaliana	49-53
32151685-9	2020	The transcriptional expressions of immune-related genes (TNF-alpha, INF-gamma and IL-1beta) in Cu, Zn, Cu + Zn groups were significantly inhibited compared with the control group after treatment for 21 days.	Zinc	99-101	interleukin-1 beta	Oreochromis niloticus	82-90
32151685-9	2020	The transcriptional expressions of immune-related genes (TNF-alpha, INF-gamma and IL-1beta) in Cu, Zn, Cu + Zn groups were significantly inhibited compared with the control group after treatment for 21 days.	Zinc	108-110	interleukin-1 beta	Oreochromis niloticus	82-90
31891920-6	2020	However, another trilayer photodetector ITO/ZnO(80nm)/CsPbBr3(50nm)/PbS(150nm)/Au showed a maximum D* of 1.73x1012 Jones with a R of 5.31 A/W under 6.8 mW/cm2 405 nm illumination.	Zinc	44-47	cholinergic receptor muscarinic 3	Homo sapiens	68-71
32032711-8	2020	Both chitosan and CH/ZnO nanocomposite downregulate the expression of LasI and RhlI genes using quantitative real-time PCR.	Zinc	21-24	acyl-homoserine-lactone synthase	Pseudomonas aeruginosa PAO1	79-83
32032711-9	2020	The expression of RhlI gene in PAO1 is reduced by 1240 folds after treatment with CH/ZnO nanocomposite.	Zinc	85-88	acyl-homoserine-lactone synthase	Pseudomonas aeruginosa PAO1	18-22
32032711-10	2020	The expression of LasI and RhlI genes in clinical isolates is reduced by 1778.07 and 627.29 folds upon treatment with CH/ZnO.	Zinc	121-124	acyl-homoserine-lactone synthase	Pseudomonas aeruginosa PAO1	27-31
32195517-8	2020	Yeast heterologous expression of CDF proteins from Chlamydomonas reinhardtii indicated Zn2+ and Co2+ transport function by CrMTP1, and Mn2+ transport function by CrMTP2, CrMTP3 and CrMTP4, which validated the phylogenetic prediction.	Zinc	87-91	uncharacterized protein	Chlamydomonas reinhardtii	123-129
32195517-9	2020	However, the Mn-CDF protein CrMTP3 was also able to provide zinc and cobalt tolerance to the Zn- and Co-sensitive zrc1 cot1 yeast strain.	Zinc	93-95	uncharacterized protein	Chlamydomonas reinhardtii	28-34
32195517-9	2020	However, the Mn-CDF protein CrMTP3 was also able to provide zinc and cobalt tolerance to the Zn- and Co-sensitive zrc1 cot1 yeast strain.	Zinc	93-95	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	114-118
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	192-196	Janus kinase 2	Homo sapiens	48-62
32090570-3	2020	The energy difference (E) at the interface between ZnS stem and Ag2S tip would be altered as the AR of Ag2S-ZnS NRs increased from 11.9 to 18.4, resulting in the enlarged driving force for the delocalized electrons along conduction band (CB) of ZnS injecting into that of Ag2S.	Zinc	51-54	angiotensin II receptor type 1	Homo sapiens	103-107
6429557-6	1984	Mg2+ activated alkaline phosphatase and showed protective effect towards inhibition by EDTA and Zn2+.	Zinc	96-100	mucin 7, secreted	Homo sapiens	0-3
32090570-3	2020	The energy difference (E) at the interface between ZnS stem and Ag2S tip would be altered as the AR of Ag2S-ZnS NRs increased from 11.9 to 18.4, resulting in the enlarged driving force for the delocalized electrons along conduction band (CB) of ZnS injecting into that of Ag2S.	Zinc	51-54	angiotensin II receptor type 1	Homo sapiens	103-107
32090570-3	2020	The energy difference (E) at the interface between ZnS stem and Ag2S tip would be altered as the AR of Ag2S-ZnS NRs increased from 11.9 to 18.4, resulting in the enlarged driving force for the delocalized electrons along conduction band (CB) of ZnS injecting into that of Ag2S.	Zinc	108-111	angiotensin II receptor type 1	Homo sapiens	64-68
32090570-3	2020	The energy difference (E) at the interface between ZnS stem and Ag2S tip would be altered as the AR of Ag2S-ZnS NRs increased from 11.9 to 18.4, resulting in the enlarged driving force for the delocalized electrons along conduction band (CB) of ZnS injecting into that of Ag2S.	Zinc	108-111	angiotensin II receptor type 1	Homo sapiens	103-107
6661500-4	1983	It is concluded from these Raman data that the interaction between polyacrylate ion and Cu2+, Zn2+ or Mn2+ includes a specific interaction with bond formation, whereas in the case of Mg2+ and Ba2+, the electrostatic interaction is dominant.	Zinc	94-98	mucin 7, secreted	Homo sapiens	183-186
32090570-3	2020	The energy difference (E) at the interface between ZnS stem and Ag2S tip would be altered as the AR of Ag2S-ZnS NRs increased from 11.9 to 18.4, resulting in the enlarged driving force for the delocalized electrons along conduction band (CB) of ZnS injecting into that of Ag2S.	Zinc	108-111	angiotensin II receptor type 1	Homo sapiens	103-107
32090570-4	2020	The interfacial electron transfer rate constant (ket) from ZnS to Ag2S could be enhanced about two-orders of magnitude from 5.27 106 to 3.24 108 s-1, leading to a significant efficiency improvement in solar hydrogen generation (SHG).	Zinc	59-62	angiotensin II receptor type 1	Homo sapiens	66-70
31546382-2	2019	The solubility, osteoinductivity, antibacterial properties and drug loading efficiency of HAp can be further enhanced by Zn doping.	Zinc	121-123	reticulon 3	Homo sapiens	90-93
31546382-3	2019	In this study, we carried out first-principles and molecular dynamics (MD) simulations to investigate the influence of Zn doping on the crystal structure and adsorption capacity of macromolecular drugs on HAp.	Zinc	119-121	reticulon 3	Homo sapiens	205-208
31546382-4	2019	Our results showed that the binding energy of doxorubicin (DOX) on HAp is significantly increased in consequence of Zn-doping.	Zinc	116-118	reticulon 3	Homo sapiens	67-70
31346859-0	2019	Neuroprotective effects of some seaweeds against Zn - induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity.	Zinc	49-51	acetylcholinesterase	Mus musculus	156-176
31346859-7	2019	Acetylcholinesterase activity was significantly high in Zn treated cells compared to the control.	Zinc	56-58	acetylcholinesterase	Mus musculus	0-20
31655152-2	2020	The prepared ZnO@CS-beta-CD was extensively characterized using XRD, FTIR, SEM, EDX with mapping, TGA, DSC and UV/vis DRS techniques and the photoreduction of Cr(VI) to Cr(III) was confirmed by X-ray photoelectron spectroscopy.	Zinc	13-16	T-box transcription factor 1	Homo sapiens	98-101
6197128-7	1983	Zn2+, a calmodulin inhibitor transported by A23187, inhibited more potently the calcium-dependent histamine release.	Zinc	0-4	calmodulin 1	Rattus norvegicus	8-18
31655152-2	2020	The prepared ZnO@CS-beta-CD was extensively characterized using XRD, FTIR, SEM, EDX with mapping, TGA, DSC and UV/vis DRS techniques and the photoreduction of Cr(VI) to Cr(III) was confirmed by X-ray photoelectron spectroscopy.	Zinc	13-16	desmocollin 3	Homo sapiens	103-106
31172426-10	2020	The MMP-2 and MMP-13 analyses showed that the expression of the high-Zn group was significantly higher than that of the normal group, indicating that Zn plays an important role in its expression.	Zinc	150-152	matrix metallopeptidase 13	Mus musculus	14-20
31846878-2	2020	Samples without Cr and increasing the presence of Cr3+ in the LDH framework in the 0.06, 0.15 and 0.3 Cr/Zn ratio were prepared by co-precipitation method, all of them constituted by pure LDH phase.	Zinc	105-107	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	50-53
31872196-8	2020	Resveratrol prevented 2-DG-induced mPTP opening and increased intracellular Zn2+ concentration indicated by TMRE and Newport Green DCF fluorescence intensity, which were further abrogated by ERK/GSK-3beta inhibitors and siRNAs.	Zinc	76-80	glycogen synthase kinase 3 alpha	Rattus norvegicus	195-204
31346859-8	2019	Pre-treatment with the seaweed extracts triggered a decrease in acetylcholinesterase activity in Zn - treated cells.	Zinc	97-99	acetylcholinesterase	Mus musculus	64-84
31693352-1	2019	Highly dense packing of chromophoric linkers is achieved in a novel pyrene-based metal-organic framework (MOF), [Zn(TBAPy)1/2(H2O)2], induced by an ionic liquid.	Zinc	113-115	lysine acetyltransferase 8	Homo sapiens	81-111
31829301-7	2020	Meanwhile, Nano-ZnO could induce neuronal repair and regeneration disorders by affecting the growth-related protein GAP-43 and delayed neurotoxicity by affecting the calcium/calcium-regulated kinase (CAMK2A/CAMK2B protein) signaling pathway.	Zinc	16-19	calcium/calmodulin dependent protein kinase II alpha	Homo sapiens	200-206
6305741-8	1983	The enzyme had a pH optimal value of about 7.0 and an apparent Km for cCMP about 2.8 mM; its activity was slightly affected by the presence of calmodulin (100 micrograms/ml) and/or CaCl2 (100 microM), but showed variable responses to other cations (La3+, Mg2+, Mn2+, Zn2+, Fe2+, Na+ and K+).	Zinc	267-271	calmodulin 1	Rattus norvegicus	143-153
31829301-7	2020	Meanwhile, Nano-ZnO could induce neuronal repair and regeneration disorders by affecting the growth-related protein GAP-43 and delayed neurotoxicity by affecting the calcium/calcium-regulated kinase (CAMK2A/CAMK2B protein) signaling pathway.	Zinc	16-19	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	207-213
31676820-3	2019	A range of enzymes, namely beta-glucosidase, invertase, beta-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process.	Zinc	132-138	galactosidase beta 1	Homo sapiens	56-88
31578859-0	2019	Correction to "Strong Phonon-Phonon Interactions Securing Extraordinary Thermoelectric Ge1-xSbxTe with Zn-Alloying-Induced Band Alignment".	Zinc	103-105	enhancer of mRNA decapping 4	Homo sapiens	87-90
7169610-3	1982	The majority of Zn2+ added to the medium was shown to be bound to serum albumin (95% out of 200 microM) by means of equilibrium dialysis.	Zinc	16-20	albumin	Mus musculus	66-79
31552971-5	2019	The maximum BET surface area was found to be 1043.65 m2 g-1 for ZIF Co/Zn = 0.5.	Zinc	71-73	delta/notch like EGF repeat containing	Homo sapiens	12-15
6894161-5	1981	Conjugase activity in bile was inhibited by Zn2+ at pH 7.5 but not at pH 4.5 and was much more stable to heat at pH 4.5.	Zinc	44-48	gamma-glutamyl hydrolase	Rattus norvegicus	0-9
31532646-4	2019	The structure may be decomposed into fragments, related to the AlB2 structure type, and could be obtained from multiplication of the unit cell, multiple substitution of Li atoms by triangles of Zn, insertion of Zn atoms, and deformation.	Zinc	194-196	afamin	Homo sapiens	63-67
31532646-4	2019	The structure may be decomposed into fragments, related to the AlB2 structure type, and could be obtained from multiplication of the unit cell, multiple substitution of Li atoms by triangles of Zn, insertion of Zn atoms, and deformation.	Zinc	211-213	afamin	Homo sapiens	63-67
6256485-3	1980	The 5"-nucleotidase in the homogenates and in isolated myelin had optimum activity at pH 7.5--9.0, was stimulated by Mg2+ and Mn2+, and was inhibited by Co2+, Zn2+, EDTA, and EGTA.	Zinc	159-163	5' nucleotidase, ecto	Rattus norvegicus	4-19
476502-1	1979	The refinement of the crystal structure of two-Zn pig insulin using 1.5-A (1A = 0.1 nm) resolution data by Fourier and fast Fourier least-squares methods allows us to make detailed comparisons between the two independent molecules present in the two-Zn insulin dimer and to describe their interactions in the monomer, dimer, and hexamer.	Zinc	47-49	insulin	Sus scrofa	54-61
31602177-1	2019	A new porous and flexible metal-organic framework (MOF) has been synthesized from the flexible asymmetric linker N-(4-carboxyphenyl)succinamate (CSA) and heptanuclear zinc oxo-clusters of formula [Zn7O2(carboxylate)10DMF2] involving two coordinated terminal DMF ligands.	Zinc	167-175	lysine acetyltransferase 8	Homo sapiens	26-55
31564457-5	2020	In particular, C-ZnMn2O4 at 350  C @12 h exhibits appreciable electrochemical performance by showing a stable and higher capacity of 600 mAhg-1 at a current density of 50 mAg-1 in the voltage range of 0.01-3.0 V and qualifies it as a better performing cost-effective anode for LIBs.	Zinc	15-24	dentin matrix protein 1	Mus musculus	171-176
31593356-5	2020	Such processing relies on specific T. cruzi proteases, including Zn-metalloproteases and collagenases, and ultimately conveys profound changes in galectin-3-dependent effects, as chemical inhibition of parasite proteases allows galectin-3 to induce parasite death in vitro.	Zinc	65-67	galectin 3	Homo sapiens	146-156
31761550-4	2020	We further discovered that surface charge of ZnO NPs were modified after Cd2+ adsorption and the resulting nanoadducts caused more severe damages in placental barriers by causing shed endothelial cells and decreased expressions of tight junction proteins ZO1, occludin, claudin-4 and claudin-8.	Zinc	45-48	occludin	Homo sapiens	260-268
31913396-6	2020	As expected, the as-prepared Ni(ii,iii)Zn-LDH/NF-nm has relatively low overpotentials of 320 and 370 mV to drive large current densities of 100 and 500 mA cm-2, respectively, and a small Tafel slope of 63.9 mV dec-1, extremely superior to RuO2/NF and NiZn-LDH/NF-ns counterpart.	Zinc	29-41	deleted in esophageal cancer 1	Homo sapiens	210-215
31602177-1	2019	A new porous and flexible metal-organic framework (MOF) has been synthesized from the flexible asymmetric linker N-(4-carboxyphenyl)succinamate (CSA) and heptanuclear zinc oxo-clusters of formula [Zn7O2(carboxylate)10DMF2] involving two coordinated terminal DMF ligands.	Zinc	197-221	lysine acetyltransferase 8	Homo sapiens	26-55
476502-1	1979	The refinement of the crystal structure of two-Zn pig insulin using 1.5-A (1A = 0.1 nm) resolution data by Fourier and fast Fourier least-squares methods allows us to make detailed comparisons between the two independent molecules present in the two-Zn insulin dimer and to describe their interactions in the monomer, dimer, and hexamer.	Zinc	47-49	insulin	Sus scrofa	253-260
33611177-9	2021	The correlation between the PM2.5 components and myocardial hypertrophy markers suggested that Zinc (Zn) and acenaphthene (AC) are related to the changes in ANP and beta-MHC at the transcriptional level, respectively.	Zinc	101-103	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	165-173
31365236-7	2019	Furthermore, Zn2+-induced closing of the proton channel Delta-Hv1 was studied with two-dimensional NMR spectroscopy, which showed that characteristic large scale dynamics of open Delta-Hv1 are absent in the closed state of the channel.	Zinc	13-17	hydrogen voltage gated channel 1	Homo sapiens	56-65
31365236-7	2019	Furthermore, Zn2+-induced closing of the proton channel Delta-Hv1 was studied with two-dimensional NMR spectroscopy, which showed that characteristic large scale dynamics of open Delta-Hv1 are absent in the closed state of the channel.	Zinc	13-17	hydrogen voltage gated channel 1	Homo sapiens	179-188
32840726-8	2021	The expression of Bcl-xL and Xiap was increased in most conditions by having high Zn in the medium regardless of the presence of insulin or IL6.	Zinc	82-84	BCL2-like 1	Mus musculus	18-24
32840726-8	2021	The expression of Bcl-xL and Xiap was increased in most conditions by having high Zn in the medium regardless of the presence of insulin or IL6.	Zinc	82-84	X-linked inhibitor of apoptosis	Mus musculus	29-33
33956221-0	2021	Enhancement of Zn tolerance and accumulation in plants mediated by the expression of Saccharomyces cerevisiae vacuolar transporter ZRC1.	Zinc	15-17	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	131-135
33956221-4	2021	The Saccharomyces cerevisiae ZRC1 gene encodes a zinc transporter which is primarily involved in the uptake of Zn into the vacuole.	Zinc	111-113	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	29-33
33462468-4	2021	We also exploited the atomic-level miscibility of Cd and Zn to synthesize Mn2+:(Cd1-xZnxSe)13 alloy suprastructures with tunable metal synergy: Mn2+:(Cd0.5Zn0.5Se)13 suprastructures demonstrated high catalytic activity (turnover number, 17,964 per cluster in 6 h; turnover frequency, 2,994 per cluster per hour) for converting CO2 to organic cyclic carbonates under mild reaction conditions.	Zinc	57-59	CD1c molecule	Homo sapiens	80-83
33512039-2	2021	PUM168 is a Zn-based MOF characterized by microporous cavities that allows the encapsulation of a significant number of guest molecules.	Zinc	12-14	lysine acetyltransferase 8	Homo sapiens	21-24
33635301-5	2021	With the ESIPT property, HL1 and HL2 could also detect Zn2+ ions via the "turn on" mode in EtOH/HEPES media.	Zinc	55-59	intelectin 2	Homo sapiens	33-36
33554430-0	2021	Synergistic Manipulation of Zn2+ Ion Flux and Desolvation Effect Enabled by Anodic Growth of a 3D ZnF2 Matrix for Long-Lifespan and Dendrite-Free Zn Metal Anodes.	Zinc	28-32	zinc finger protein 2	Homo sapiens	98-102
31321447-3	2019	In vivo, Cav2.3 channels are thought to be under tight allosteric control by endogenous loosely bound trace metal cations (Zn2+ and Cu2+) that suppress channel gating via a high-affinity trace metal-binding site.	Zinc	123-127	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	9-15
31636842-2	2019	In mammalian cells, Zn transporters such as ZIP8 and ZIP14 have been found to function as the transporters for Mn(II) and Cd(II), contributing to the maintenance of Mn homeostasis and metallothionein-independent transports of Cd, respectively.	Zinc	20-22	solute carrier family 39 member 8	Homo sapiens	44-48
31636842-2	2019	In mammalian cells, Zn transporters such as ZIP8 and ZIP14 have been found to function as the transporters for Mn(II) and Cd(II), contributing to the maintenance of Mn homeostasis and metallothionein-independent transports of Cd, respectively.	Zinc	20-22	solute carrier family 39 member 14	Homo sapiens	53-58
31767137-4	2020	Importantly, we notified that transition metals such as copper (II) and zinc (II) interfere with the MIF tautomerase activity under the assay conditions applied.	Zinc	72-81	macrophage migration inhibitory factor	Homo sapiens	101-104
31838698-2	2020	Al-doped ZnO (ZnO:Alx%) nanopowders with 0 to 5% Al content are prepared via an amended sol-gel method.	Zinc	9-12	hematopoietic SH2 domain containing	Homo sapiens	18-21
31838698-3	2020	The morphology and microstructure of the prepared ZnO:Alx% are probed by means of scanning electron microscopy (SEM), X-ray particles diffraction (XRD) analysis, energy dispersive X-ray spectroscopy (EDS) and elemental mapping.	Zinc	50-53	hematopoietic SH2 domain containing	Homo sapiens	54-57
31838698-8	2020	The ZnO:Alx% with 1 wt% Al exhibits the highest uptake rate of heavy metal ions.	Zinc	4-7	hematopoietic SH2 domain containing	Homo sapiens	8-11
31838698-11	2020	Desorption studies with 0.1 M NaOH indicate that ZnO:Alx% can be regenerated effectively.	Zinc	49-52	hematopoietic SH2 domain containing	Homo sapiens	53-56
31878012-8	2019	From the TGA data, it is clear that the addition of ZnO NPs could change the thermal degradation behaviors of coatings with increasing char residue percentage at high temperatures.	Zinc	52-55	T-box transcription factor 1	Homo sapiens	9-12
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	growth hormone receptor	Oryctolagus cuniculus	196-219
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	growth hormone receptor	Oryctolagus cuniculus	221-224
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	fibroblast growth factor 1	Oryctolagus cuniculus	227-253
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	fibroblast growth factor 1	Oryctolagus cuniculus	255-259
31842499-6	2019	On the other hand, mRNA of FGF1, TGF1, TCIRG1, and adenosine deaminase (ADA) were higher expressed (p &lt; 0.05) in the spleen tissues of Cu/Zn-Mnt group.	Zinc	141-143	fibroblast growth factor 1	Oryctolagus cuniculus	27-31
31842499-6	2019	On the other hand, mRNA of FGF1, TGF1, TCIRG1, and adenosine deaminase (ADA) were higher expressed (p &lt; 0.05) in the spleen tissues of Cu/Zn-Mnt group.	Zinc	141-143	TCIRG1	Oryctolagus cuniculus	39-45
31714570-3	2019	The present work shows the first case of employing pressure hydrogenation to prepare hydrogenated ZnIn2S4 (H-ZIS) microspheres with surface-deficient porous structures, which are favorable for furnishing sufficient surface sulfur vacancies to realize excellent photocatalytic hydrogen evolution reactions.	Zinc	98-105	zinc finger RANBP2-type containing 2	Homo sapiens	109-112
33554430-3	2021	In this work, a 3D interconnected ZnF2 matrix is designed on the surface of Zn foil (Zn@ZnF2 ) through a simple and fast anodic growth method, serving as a multifunctional protective layer.	Zinc	34-36	zinc finger protein 2	Homo sapiens	88-92
33554430-3	2021	In this work, a 3D interconnected ZnF2 matrix is designed on the surface of Zn foil (Zn@ZnF2 ) through a simple and fast anodic growth method, serving as a multifunctional protective layer.	Zinc	76-78	zinc finger protein 2	Homo sapiens	34-38
33554430-3	2021	In this work, a 3D interconnected ZnF2 matrix is designed on the surface of Zn foil (Zn@ZnF2 ) through a simple and fast anodic growth method, serving as a multifunctional protective layer.	Zinc	76-78	zinc finger protein 2	Homo sapiens	88-92
33554430-4	2021	The as-fabricated Zn@ZnF2 electrode can not only redistribute the Zn2+ ion flux, but also reduce the desolvation active energy significantly, leading to stable and facile Zn deposition kinetics.	Zinc	18-20	zinc finger protein 2	Homo sapiens	21-25
33554430-4	2021	The as-fabricated Zn@ZnF2 electrode can not only redistribute the Zn2+ ion flux, but also reduce the desolvation active energy significantly, leading to stable and facile Zn deposition kinetics.	Zinc	66-70	zinc finger protein 2	Homo sapiens	21-25
33554430-5	2021	The results reveal that the Zn@ZnF2 electrode can effectively inhibit dendrites growth, restrain the hydrogen evolution reactions, and endow excellent plating/stripping reversibility.	Zinc	28-30	zinc finger protein 2	Homo sapiens	31-35
33554430-6	2021	Accordingly, the Zn@ZnF2 electrode exhibits a long cycle life of over 800 h at 1 mA cm-2 with a capacity of 1.0 mAh cm-2 in a symmetrical cell test, the feasibility of which is also convincing in Zn@ZnF2 //MnO2 and Zn@ZnF2 //V2 O5 full batteries.	Zinc	17-19	zinc finger protein 2	Homo sapiens	20-24
33554430-6	2021	Accordingly, the Zn@ZnF2 electrode exhibits a long cycle life of over 800 h at 1 mA cm-2 with a capacity of 1.0 mAh cm-2 in a symmetrical cell test, the feasibility of which is also convincing in Zn@ZnF2 //MnO2 and Zn@ZnF2 //V2 O5 full batteries.	Zinc	17-19	zinc finger protein 2	Homo sapiens	199-203
33554430-6	2021	Accordingly, the Zn@ZnF2 electrode exhibits a long cycle life of over 800 h at 1 mA cm-2 with a capacity of 1.0 mAh cm-2 in a symmetrical cell test, the feasibility of which is also convincing in Zn@ZnF2 //MnO2 and Zn@ZnF2 //V2 O5 full batteries.	Zinc	17-19	zinc finger protein 2	Homo sapiens	199-203
33554430-7	2021	Importantly, a hybrid zinc-ion capacitor of the Zn@ZnF2 //AC can work at an ultrahigh current density of  60 mA cm-2 for up to 5000 cycles with a high capacity retention of 92.8%.	Zinc	48-50	zinc finger protein 2	Homo sapiens	51-55
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	22-26	adenosine A1 receptor	Mus musculus	106-112
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	170-174	adenosine A1 receptor	Mus musculus	106-112
33360236-8	2021	The expression of ZmPIP1;1, ZmPIP1;2, and ZmPIP2;2 was significantly higher with moderate Zn treatment than that of low-level Zn treatment.	Zinc	90-92	aquaporin PIP1-2	Zea mays	28-36
33188635-9	2021	Job"s Plot showed that the stoichiometric ratio of the complex formed by HL2 and Zn2+ ions is 2:1 (ligand:metal).	Zinc	81-85	intelectin 2	Homo sapiens	73-76
32579250-2	2020	A plant cadmium (Cd) and zinc (Zn) transporter (AtHMA4) was used as a transgene to increase the ability of Chlamydomonas reinhardtii to tolerate 0.2 mM Cd and 0.3 mM Zn exposure.	Zinc	31-33	heavy metal atpase 4	Arabidopsis thaliana	48-54
32579250-2	2020	A plant cadmium (Cd) and zinc (Zn) transporter (AtHMA4) was used as a transgene to increase the ability of Chlamydomonas reinhardtii to tolerate 0.2 mM Cd and 0.3 mM Zn exposure.	Zinc	166-168	heavy metal atpase 4	Arabidopsis thaliana	48-54
32825449-11	2020	Also, there was a reduction in the Zn-induced enhancement of ZnT1 protein level in the small intestine.	Zinc	35-37	solute carrier family 30 (zinc transporter), member 1	Mus musculus	61-65
32825449-12	2020	Zn + IMI also induced an increase in the ZnT4 protein level in the PFC compared to the control group and normalized the Zn-induced decrease in the ZnT1 protein level in the hippocampus (Hp).	Zinc	0-2	solute carrier family 30 (zinc transporter), member 1	Mus musculus	147-151
32510447-3	2020	Interestingly, the adsorption of Cr3+ at high and low concentrations was very fast, and equilibrium was achieved within 2 min compared to Cu2+ and Zn2+ which needed 30 and 60 min to reach equilibrium, respectively.	Zinc	147-151	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	33-36
31482704-4	2019	Because SnS2 is insoluble in acidic condition, it is easy to create a yolk-shell architecture by selectively removing the ZnS component.	Zinc	122-125	sodium voltage-gated channel alpha subunit 11	Homo sapiens	8-12
31469368-8	2019	Moreover, zctr1 overexpression made ZFL cells more sensitive to Cu and Zn exposure, and overexpression of zatox1 or zatp7b increased Cu uptake and Cu tolerance in ZFL cells.	Zinc	71-73	solute carrier family 31 member 1	Danio rerio	10-15
32510447-9	2020	The adsorption of Zn2+, Cu2+, and Cr3+ was spontaneous, endothermic, and physical for Cu2+ and Cr3+, while exothermic and chemical for Zn2+.	Zinc	18-22	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	34-37
31754889-4	2019	We found that the [Zn2+]i probe FluoZin-3 and the traditional [Ca2+]i probe fura-2 responded most consistently and robustly to [Cd2+]i accumulation mediated by voltage-gated calcium channels.	Zinc	19-23	CD2 antigen	Mus musculus	128-131
32510447-9	2020	The adsorption of Zn2+, Cu2+, and Cr3+ was spontaneous, endothermic, and physical for Cu2+ and Cr3+, while exothermic and chemical for Zn2+.	Zinc	18-22	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	95-98
32510447-9	2020	The adsorption of Zn2+, Cu2+, and Cr3+ was spontaneous, endothermic, and physical for Cu2+ and Cr3+, while exothermic and chemical for Zn2+.	Zinc	135-139	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	34-37
32229323-2	2020	The results showed decreased Cat1 and Cat2 signals for the Zn(II)-loaded MT3 species with respect to the metal-free protein, which might be explained by the arrangement of tetrahedral metal-thiolate coordination environments and the formation of metal clusters.	Zinc	59-65	solute carrier family 7 member 2	Homo sapiens	38-42
31799425-4	2019	Previously, we showed that the BTB/POZ-Zn-finger protein Mamo is necessary for vasa expression in Drosophila.	Zinc	35-41	vasa	Drosophila melanogaster	79-83
32124714-6	2019	Zn contents (P < 0 001) in yolk and serum, Ca, albumin (Alb) levels in ESG as well as carbonic anhydrase (CA) activity in serum (P < 0 05) and mRNA levels of CA and Ca-binding protein-d28k (CaBP-D28k) (P < 0 001) in the 80 mg/kg Zn-Met group were the highest among all treatments.	Zinc	0-2	albumin	Gallus gallus	47-54
32124714-6	2019	Zn contents (P < 0 001) in yolk and serum, Ca, albumin (Alb) levels in ESG as well as carbonic anhydrase (CA) activity in serum (P < 0 05) and mRNA levels of CA and Ca-binding protein-d28k (CaBP-D28k) (P < 0 001) in the 80 mg/kg Zn-Met group were the highest among all treatments.	Zinc	0-2	albumin	Gallus gallus	56-59
31508411-4	2019	The partial vaporization of Zn and the stabilizing effect of N, illustrated by XRD, HRTEM, HAADF-STEM with mapping, SEM, Raman Spectrum, BET, and TGA, were able to remarkably increase the accessibility of substrate toward active sites and prevent the aggregation of metal particles, respectively.	Zinc	28-30	delta/notch like EGF repeat containing	Homo sapiens	137-140
31508411-4	2019	The partial vaporization of Zn and the stabilizing effect of N, illustrated by XRD, HRTEM, HAADF-STEM with mapping, SEM, Raman Spectrum, BET, and TGA, were able to remarkably increase the accessibility of substrate toward active sites and prevent the aggregation of metal particles, respectively.	Zinc	28-30	T-box transcription factor 1	Homo sapiens	146-149
31346193-5	2019	Zn induces the production of a variety of pro-inflammatory cytokines including IL-6 through signaling pathways mediated by the Zn receptor GPR39.	Zinc	0-2	G protein-coupled receptor 39	Mus musculus	139-144
31346193-7	2019	Thus, our results show that Zn and mast cells play a critical role in wound healing through activation of the GPR39/IL-6 signaling axis.	Zinc	28-30	G protein-coupled receptor 39	Mus musculus	110-115
32124714-8	2019	Also, the increase in Zn-Met-induced Ca deposition may be due to the increased Zn contents in serum and tissues, which were attributable to the increased CA concentrations in serum, Ca, Alb levels and up-regulated CA and CaBP-D28k mRNA levels in ESG.	Zinc	22-24	albumin	Gallus gallus	186-189
32076742-6	2020	For example, protein phosphorylation was found to regulate ZIP7 activity resulting in the release of Zn2+ from intracellular stores leading to phosphorylation of tyrosine kinases and activation of signaling pathways.	Zinc	101-105	solute carrier family 39 member 7	Homo sapiens	59-63
31441970-5	2019	Within 2,5-NH2Cl, the eta value becomes larger as the metal are varied from Co to Zn.	Zinc	82-84	endothelin receptor type A	Homo sapiens	22-25
31220150-15	2019	Moreover, both the proteins showed OP hydrolase activities in the presence of Ca2+ as well as Zn2+, suggesting the metal-dependent promiscuous nature of SMP30.	Zinc	94-98	regucalcin	Homo sapiens	153-158
31460120-0	2019	Zn-Catalyzed Multicomponent KA2 Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers.	Zinc	0-2	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	28-31
32645059-4	2020	The solute carrier (SLC) protein SLC39A7, a Zn2+ importer, has recently been linked to asthma.	Zinc	44-48	solute carrier family 39 member 7	Homo sapiens	33-40
30907040-3	2019	We construct In- and Zn/In-doped SnS2 nanosheet arrays through a hydrothermal method.	Zinc	21-23	sodium voltage-gated channel alpha subunit 11	Homo sapiens	33-37
31517402-4	2019	By introducing guest iron (Fe) ions into the core@shell MOF precursor, the open carbon cages are self-assembled into a hydrangea-like 3D superstructure interconnected by carbon nanotubes, which are grown in situ on the Fe-Co alloy nanoparticles formed during the pyrolysis of Fe-introduced Zn@Co-MOFs.	Zinc	290-292	lysine acetyltransferase 8	Homo sapiens	56-59
31828721-5	2020	Zn supplementation increased the decreased parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), metallothionein (MT), protein sulfhydryl (P-SH), and nuclear factor-erythroid 2-related factor-2 (Nrf2) expression and decreased the increased elements such as endoplasmic reticulum (ER) stress, mitochondrial permeability transition pore (mPTP) opening, malondialdehyde (MDA), serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and microRNAs-(122 and 34a), apoptotic factors, and histopathological changes.	Zinc	0-2	glutamic--pyruvic transaminase	Homo sapiens	483-507
32591593-4	2020	For the chemical structure design, in silico tools (molecular docking, molecular dynamic (MD) simulations, ADME/Tox properties were used to target Zn2+ atoms and HDAC hydrophobic cavities.	Zinc	147-151	thymocyte selection associated high mobility group box	Homo sapiens	107-115
31450362-10	2019	The as-synthesized Zn0.35Fe2.65O4 nanostructure was characterized through the SEM, EDX, TEM, CV, DRS, BET, VSM, and XRD.	Zinc	19-22	sushi repeat containing protein X-linked	Homo sapiens	97-100
31450362-10	2019	The as-synthesized Zn0.35Fe2.65O4 nanostructure was characterized through the SEM, EDX, TEM, CV, DRS, BET, VSM, and XRD.	Zinc	19-22	delta/notch like EGF repeat containing	Homo sapiens	102-105
31709314-8	2019	The presence of Zn2+ ions inhibited the formation of hydroxycarbonate apatite (HCAp) on the particles after immersion in simulated body fluid (SBF).	Zinc	16-20	HCA1	Homo sapiens	79-83
31352117-8	2019	The mRNA expression profile of both interleukin 8 (IL-8), interleukin 1, beta (IL-1beta) encoding genes showed an up-regulation that was found in all Zn- supplemented groups, but more pronounced in nZnO60-supplemented group.	Zinc	150-152	interleukin-8	Oreochromis niloticus	36-49
31352117-8	2019	The mRNA expression profile of both interleukin 8 (IL-8), interleukin 1, beta (IL-1beta) encoding genes showed an up-regulation that was found in all Zn- supplemented groups, but more pronounced in nZnO60-supplemented group.	Zinc	150-152	interleukin-8	Oreochromis niloticus	51-55
30468883-2	2019	Previous studies have shown that zinc (Zn(II)) and insulin, co-secreted with hIAPP, have an inhibition effect on hIAPP aggregation.	Zinc	39-45	islet amyloid polypeptide	Homo sapiens	77-82
30468883-2	2019	Previous studies have shown that zinc (Zn(II)) and insulin, co-secreted with hIAPP, have an inhibition effect on hIAPP aggregation.	Zinc	39-45	islet amyloid polypeptide	Homo sapiens	113-118
30468883-8	2019	Circular dichroism experiments indicate the formation and stabilization of a helical structure of hIAPP in presence of the EGCG:Zn(II) complex.	Zinc	128-134	islet amyloid polypeptide	Homo sapiens	98-103
30468883-9	2019	Our results also reveal the ability of EGCG or EGCG:Zn(II) to efficiently suppress hIAPP"s cellular toxicity.	Zinc	52-58	islet amyloid polypeptide	Homo sapiens	83-88
30690405-5	2019	Secondly, Zn pre-exposure reduced Cd accumulation at 100 and 200 mug/L Cd, down-regulated il-6 and il-1beta at 100 mug/L Cd and p65 at 200 mug/L Cd, and increased Cu/Zn-SOD and CAT activities at 200 mug/L Cd.	Zinc	10-12	v-rel avian reticuloendotheliosis viral oncogene homolog A	Danio rerio	128-131
30611496-3	2019	In polyaniline chitosan silver nanocomposite adsorbed beta-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn2+, K+, Ca2+ and Mn2+ ions.	Zinc	165-169	galactosidase beta 1	Homo sapiens	54-72
30668786-8	2019	From 1 to 28, organic Zn increased BW gain (P = 0.02), and improved FCR (P = 0.03) vs. birds fed ZnSO4.	Zinc	22-24	FCR	Gallus gallus	68-71
30668786-11	2019	In the jejunum, organic Zn fed birds showed a downregulation of expression of IL-8 (P = 0.02), and upregulation of IL-10 (P = 0.05) in CoCPF birds vs. ZnSO4- CoCPF birds.	Zinc	24-26	interleukin 8-like 2	Gallus gallus	78-82
30890462-0	2019	Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells.	Zinc	81-85	parathyroid hormone like hormone	Homo sapiens	0-11
30890462-11	2019	These Zn-MBGs scaffolds showed 3D hierarchical meso-macroporous structure that enables to host and release osteostatin.	Zinc	6-8	parathyroid hormone like hormone	Homo sapiens	107-118
30810529-4	2019	Here we show that hTMEM266 forms oligomers, undergoes both rapid (micros) and slow (ms) structural rearrangements in response to changes in voltage, and contains a Zn2+ binding site that can regulate the slow conformational transition.	Zinc	164-168	transmembrane protein 266	Homo sapiens	18-26
30406698-6	2019	Zn2+ ameliorated this perturbed barrier by redistribution of claudin-2 and -4 back to the plasma membrane and by modulating the phosphorylation state of TJ proteins t hough extracellular signal-regulated kinase (ERK)1/2 dependency.	Zinc	0-4	claudin 2	Mus musculus	61-77
30406698-6	2019	Zn2+ ameliorated this perturbed barrier by redistribution of claudin-2 and -4 back to the plasma membrane and by modulating the phosphorylation state of TJ proteins t hough extracellular signal-regulated kinase (ERK)1/2 dependency.	Zinc	0-4	mitogen-activated protein kinase 3	Mus musculus	173-219
30406698-7	2019	Zn2+ prevents elevation of IL-6 and IL-8.	Zinc	0-4	chemokine (C-X-C motif) ligand 15	Mus musculus	36-40
30406698-10	2019	Zn2+ supplementation ameliorated this barrier dysfunction, and the inflammatory response involving ERK-mediated change of phosphorylation status for claudin-2 and -4.	Zinc	0-4	claudin 2	Mus musculus	149-165
30299460-4	2019	At the terminal experiment, there were significant differences between control and 80 mg/kg Zn-Met group in feed intake (P &lt; 0.05) and feed conversion ratio (FCR) (P &lt; 0.01).	Zinc	92-94	FCR	Gallus gallus	138-159
30299460-4	2019	At the terminal experiment, there were significant differences between control and 80 mg/kg Zn-Met group in feed intake (P &lt; 0.05) and feed conversion ratio (FCR) (P &lt; 0.01).	Zinc	92-94	FCR	Gallus gallus	161-164
30534759-2	2019	In contrast to the Zn-based metal-organic framework (Zn-MOF), the cooperative assembly of POM and a Zn/trz macrocycle gave rise to high stability and good electrochemical ability of the Zn-POMCF in lithium-ion batteries (LIBs).	Zinc	53-55	lysine acetyltransferase 8	Homo sapiens	56-59
31787719-4	2019	Here, we determined the three-dimensional X-ray crystal structure of RNase He1 in complex with Zn, which revealed that Zn binding most likely prevents substrate entry into the active site due to steric hindrance.	Zinc	95-97	NPC intracellular cholesterol transporter 2	Homo sapiens	75-78
31787719-4	2019	Here, we determined the three-dimensional X-ray crystal structure of RNase He1 in complex with Zn, which revealed that Zn binding most likely prevents substrate entry into the active site due to steric hindrance.	Zinc	119-121	NPC intracellular cholesterol transporter 2	Homo sapiens	75-78
31787719-5	2019	This could explain why RNase He1 and other T1 family RNases are inhibited by Zn.	Zinc	77-79	NPC intracellular cholesterol transporter 2	Homo sapiens	29-32
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	v-rel avian reticuloendotheliosis viral oncogene homolog A	Danio rerio	127-130
31474742-4	2019	The results showed that the uptakes of Cd2+ and Mn2+ from apical sides were the highest in S3 cells, and Cd2+, Mn2+, and Zn2+ mutually inhibited the apical uptake of each metal.	Zinc	121-125	CD2 antigen	Mus musculus	39-42
31474742-4	2019	The results showed that the uptakes of Cd2+ and Mn2+ from apical sides were the highest in S3 cells, and Cd2+, Mn2+, and Zn2+ mutually inhibited the apical uptake of each metal.	Zinc	121-125	CD2 antigen	Mus musculus	105-108
29307859-4	2019	Since we recently have shown how hyperglycemia (HG)-induced changes in ZIP7 and ZnT7 contribute to Zn2+-transport across S(E)R and contribute to S(E)R-stress in the heart, herein, we hypothesized that these transporters can also be localized to mitochondria and affect the S(E)R-mitochondria coupling, and thereby contribute to cellular Zn2+-muffling between S(E)R-mitochondria in HG-cells.	Zinc	99-103	solute carrier family 39 member 7	Homo sapiens	71-75
29307859-4	2019	Since we recently have shown how hyperglycemia (HG)-induced changes in ZIP7 and ZnT7 contribute to Zn2+-transport across S(E)R and contribute to S(E)R-stress in the heart, herein, we hypothesized that these transporters can also be localized to mitochondria and affect the S(E)R-mitochondria coupling, and thereby contribute to cellular Zn2+-muffling between S(E)R-mitochondria in HG-cells.	Zinc	337-341	solute carrier family 39 member 7	Homo sapiens	71-75
29307859-9	2019	Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and S(E)R and contribute to cellular Zn2+-muffling between cellular-compartments in HG or hypertrophic cardiomyocytes via affecting S(E)R-mitochondria coupling.	Zinc	155-159	solute carrier family 39 member 7	Homo sapiens	72-76
30357199-1	2018	Copper transfer from Cu(ii)amyloid-beta4-16 to human Zn7-metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA.	Zinc	53-55	tubulin beta 3 class III	Homo sapiens	35-43
30402029-2	2018	Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect against glutamate-induced neuronal cell death by inhibiting Ca2+ and Zn2+ signaling.	Zinc	154-158	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	0-25
31352117-8	2019	The mRNA expression profile of both interleukin 8 (IL-8), interleukin 1, beta (IL-1beta) encoding genes showed an up-regulation that was found in all Zn- supplemented groups, but more pronounced in nZnO60-supplemented group.	Zinc	150-152	interleukin-1 beta	Oreochromis niloticus	58-77
31352117-8	2019	The mRNA expression profile of both interleukin 8 (IL-8), interleukin 1, beta (IL-1beta) encoding genes showed an up-regulation that was found in all Zn- supplemented groups, but more pronounced in nZnO60-supplemented group.	Zinc	150-152	interleukin-1 beta	Oreochromis niloticus	79-87
31451914-8	2019	ASIC currents were increased by 20% upon extracellular application of Zn2+ (300 muM) (p < 0.05, n = 13).	Zinc	70-74	acid-sensing (proton-gated) ion channel 1	Mus musculus	0-4
32274925-7	2020	We hypothesized that As3+ could displace Zn2+ from ZRANB2 altering its structure, expression and splicing function.	Zinc	41-45	zinc finger RANBP2-type containing 2	Homo sapiens	51-57
31553739-1	2019	We identified a mouse strain, HLB444, carrying an N-ethyl-N-nitrosourea (ENU)-induced mutation in a highly conserved C2H2 zinc-finger DNA binding motif of the transcriptional regulator KLF15 that exhibits resistance to diet-induced obesity.	Zinc	117-126	Kruppel-like factor 15	Mus musculus	185-190
30500804-0	2018	Photocatalytic performance of Ag2S/ZnO/ZnS nanocomposites with high visible light response prepared via microwave-assisted hydrothermal two-step method.	Zinc	39-42	angiotensin II receptor type 1	Homo sapiens	30-34
32274925-16	2020	We conclude that As3+ exposure displaces Zn2+ from ZRANB2 zfms, changing its structure and compromising splicing of its targets, and increases ZRANB2 protein expression as a homeostatic response both at environmental/toxicological exposures and therapeutically relevant doses.	Zinc	41-45	zinc finger RANBP2-type containing 2	Homo sapiens	51-57
30500804-3	2018	At the same time, due to the introduction of narrow band gap Ag2S, the synthesized composite can effectively increase the visible optical absorption of ZnO/ZnS composites.	Zinc	156-159	angiotensin II receptor type 1	Homo sapiens	61-65
29680883-4	2019	The results revealed that the broilers receiving a probiotic mixture alone or in combination with Zn (30 and 60 mg) increased (P < 0.05) final body weight, feed conversion ratio (FCR), and total goblet cell count in duodenum compared with the control group.	Zinc	98-100	FCR	Gallus gallus	179-182
32044631-3	2020	The obtained ZnO/In2O3 heterostructures were carefully characterized by XRD, SEM, HRTEM, BET and XPS.	Zinc	13-16	delta/notch like EGF repeat containing	Homo sapiens	89-92
31461891-0	2019	Conformation and Domain Movement Analysis of Human Matrix Metalloproteinase-2: Role of Associated Zn2+ and Ca2+ Ions.	Zinc	98-102	matrix metallopeptidase 2	Homo sapiens	51-77
30206119-9	2018	Our findings indicate that CARD9 is a potential target of Zn2+-mediated signaling that affects Bcl10 polymerization in innate immune responses.	Zinc	58-62	BCL10 immune signaling adaptor	Homo sapiens	95-100
32329619-7	2020	In addition, from PBE+U approach, we have investigated the localization of the Zn $d$-states and its effect on the band gap in the ZnX and ZnF$_{2}$.	Zinc	79-81	zinc finger protein 763	Homo sapiens	139-142
30203961-1	2018	A new generation-2 light-responsive metal-organic framework (MOF) has been successfully synthesized using Zn as the metal source and both 2-phenyldiazenyl terephthalic acid and 1,4-diazabicyclo[2.2.2]octane (DABCO) as the ligands.	Zinc	106-108	lysine acetyltransferase 8	Homo sapiens	36-65
31792980-7	2020	At low micromolar concentrations, Zn2+ caused MC4 R-dependent activation of the cAMP pathway, whereas Cu2+ reduced the activity of MC4 R even below the basal level.	Zinc	34-38	melanocortin receptor 4	Cricetulus griseus	46-51
30250952-4	2018	Data from XRD and TEM indicate that photocatalysis might contribute to the formation of the strong interfacial interaction between ZnS and Ag2S nanoparticles.	Zinc	131-134	angiotensin II receptor type 1	Homo sapiens	139-143
30250952-7	2018	Superior photocatalytic performance was exhibited by the Zn0.5Ag0.5S catalyst owing to its large surface area and the presence of Ag0 with improved charge transfer in comparison with that of bare ZnS and Ag2S.	Zinc	57-60	angiotensin II receptor type 1	Homo sapiens	204-208
31792980-8	2020	These findings indicate that at physiologically relevant concentrations can Zn2+ and Cu2+ function as MC4 R agonists or inverse agonists, respectively.	Zinc	76-80	melanocortin receptor 4	Cricetulus griseus	102-107
31792980-9	2020	This means that depending on the level of constitutive activity induced by Zn2+ ions, the pharmacological effect of orthosteric ligands of MC4 R can be switched from a partial to an inverse agonist.	Zinc	75-79	melanocortin receptor 4	Cricetulus griseus	139-144
30204443-0	2018	Zn2+-Binding to the Voltage-Gated Proton Channel Hv1/VSOP.	Zinc	0-4	hydrogen voltage gated channel 1	Homo sapiens	49-52
32208668-0	2020	Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.	Zinc	136-139	elastase, neutrophil expressed	Homo sapiens	6-25
30204443-0	2018	Zn2+-Binding to the Voltage-Gated Proton Channel Hv1/VSOP.	Zinc	0-4	hydrogen voltage gated channel 1	Homo sapiens	53-57
30031876-0	2018	Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.	Zinc	0-8	NFS1 cysteine desulfurase	Homo sapiens	71-75
30031876-8	2018	Indeed, removal of zinc(II) ion from ISCU causes a moderate but significant increase in activity compared to SDA alone, and FXN can activate both zinc-depleted and zinc-bound forms of ISCU complexed to SDA.	Zinc	19-27	frataxin	Homo sapiens	124-127
32363330-6	2020	To identify the most suitable conditions for the shell growth, we first developed a synthesis route to Zn x Mg1-x Se nanocrystals (NCs) wherein Mg is effectively incorporated.	Zinc	103-105	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	108-111
29458585-1	2018	We report the design and synthesis of a novel chemosensor (Rh6G-Cin) rhodamine-based indicator for selective detection of Zn2+ ion.	Zinc	122-126	pyridoxal phosphatase	Homo sapiens	64-67
29458585-2	2018	Rh6G-Cin displayed high selectivity towards Zn2+ from various metal ions, including Ca2+, Ag+, Cd2+, Co2+, Cu2+, Al3+, Zn2+, Cr3+, Ba2+, Fe2+, Fe3+, Gd3+, Hg2+, Mg2+, Mn2+, Nd3+, Pb2+, Sr2+ and Ni2+, and the resultant complex is [Rh6G-Cin-Zn2+].	Zinc	44-48	pyridoxal phosphatase	Homo sapiens	5-8
29458585-2	2018	Rh6G-Cin displayed high selectivity towards Zn2+ from various metal ions, including Ca2+, Ag+, Cd2+, Co2+, Cu2+, Al3+, Zn2+, Cr3+, Ba2+, Fe2+, Fe3+, Gd3+, Hg2+, Mg2+, Mn2+, Nd3+, Pb2+, Sr2+ and Ni2+, and the resultant complex is [Rh6G-Cin-Zn2+].	Zinc	44-48	pyridoxal phosphatase	Homo sapiens	235-238
30197701-9	2018	Results: Our studies describe the behavior of these channels Cav3.2 and Cav3.3 and also their current sensitivity to Zinc (Zn2+) in transfected HEK-293/tsA-201cells.	Zinc	123-127	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	61-67
30197701-11	2018	We observe that Zn2+ differentially modulates the CaV3.2 and CaV3.3 channels.	Zinc	16-20	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	50-56
30197701-11	2018	We observe that Zn2+ differentially modulates the CaV3.2 and CaV3.3 channels.	Zinc	16-20	caveolin 3	Homo sapiens	50-54
30197701-12	2018	Zn2+ preferably inhibits Cav3.2.	Zinc	0-4	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	25-31
30197701-13	2018	Conclusion: We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.	Zinc	38-42	caveolin 3	Homo sapiens	72-76
30197701-13	2018	Conclusion: We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.	Zinc	38-42	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	87-93
30197701-13	2018	Conclusion: We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.	Zinc	38-42	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	139-145
30003078-3	2018	The satisfactory PLS1 regression models between sensor array optical response and analyte concentration were obtained for Cd2+, Cu2+, Zn2+, and NO2- ions in all the range of tested concentrations.	Zinc	134-138	plastin 1	Homo sapiens	17-21
29912588-9	2018	Meanwhile, Zn2+-activated autophagy and lipid depletion were via enhancing metal response element-binding transcription factor (MTF)-1 DNA binding at PPARalpha promoter region, which in turn induced transcriptional activation of the key genes related to autophagy and lipolysis.	Zinc	11-15	metal regulatory transcription factor 1	Homo sapiens	75-134
29912588-10	2018	Zn activated the pathways of Zn2+/MTF-1/ Peroxisome proliferator-activated receptor (PPAR)alpha and Ca2+/CaMKKbeta/AMPK, resulting in the up-regulation of lipophagy and accordingly reduced hepatic lipid accumulation.	Zinc	0-2	metal regulatory transcription factor 1	Homo sapiens	34-39
29912588-12	2018	The present study also indicated the novel mechanism for Zn-induced lipolysis by the activation of Zn2+/MTF-1/PPARalpha and Ca2+/CaMKKbeta/AMPK pathways, which induced the occurrence of lipophagy.	Zinc	57-59	metal regulatory transcription factor 1	Homo sapiens	104-109
29743298-0	2018	Coupling between an electrostatic network and the Zn2+ binding site modulates Hv1 activation.	Zinc	50-54	hydrogen voltage gated channel 1	Homo sapiens	78-81
29743298-1	2018	The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effects on GAQ gating, the atomic structure of the Zn2+ coordination site and mechanism by which extracellular Zn2+ stabilizes a closed-state conformation remain unknown.	Zinc	172-176	hydrogen voltage gated channel 1	Homo sapiens	34-37
29743298-1	2018	The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effects on GAQ gating, the atomic structure of the Zn2+ coordination site and mechanism by which extracellular Zn2+ stabilizes a closed-state conformation remain unknown.	Zinc	230-234	hydrogen voltage gated channel 1	Homo sapiens	34-37
29743298-1	2018	The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effects on GAQ gating, the atomic structure of the Zn2+ coordination site and mechanism by which extracellular Zn2+ stabilizes a closed-state conformation remain unknown.	Zinc	230-234	hydrogen voltage gated channel 1	Homo sapiens	34-37
29743298-1	2018	The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effects on GAQ gating, the atomic structure of the Zn2+ coordination site and mechanism by which extracellular Zn2+ stabilizes a closed-state conformation remain unknown.	Zinc	230-234	hydrogen voltage gated channel 1	Homo sapiens	34-37
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	63-67	hydrogen voltage gated channel 1	Homo sapiens	260-263
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	63-67	hydrogen voltage gated channel 1	Homo sapiens	271-274
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	159-163	hydrogen voltage gated channel 1	Homo sapiens	260-263
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	159-163	hydrogen voltage gated channel 1	Homo sapiens	271-274
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	159-163	hydrogen voltage gated channel 1	Homo sapiens	260-263
29743298-2	2018	Here we use His mutagenesis to identify residues that increase Zn2+ potency and are therefore likely to participate in first solvation shell interactions with Zn2+ Experimental Zn2+-mapping data were then used to constrain the structure of a new resting-state Hv1 model (Hv1 F).	Zinc	159-163	hydrogen voltage gated channel 1	Homo sapiens	271-274
29743298-3	2018	Molecular dynamics (MD) simulations show how protein and water atoms directly contribute to octahedral Zn2+ coordination spheres in Zn2+-bound and -unbound Hv1 F models.	Zinc	103-107	hydrogen voltage gated channel 1	Homo sapiens	156-159
29743298-3	2018	Molecular dynamics (MD) simulations show how protein and water atoms directly contribute to octahedral Zn2+ coordination spheres in Zn2+-bound and -unbound Hv1 F models.	Zinc	132-136	hydrogen voltage gated channel 1	Homo sapiens	156-159
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	Smc5-Smc6 complex subunit NSE1	Saccharomyces cerevisiae S288C	56-60
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	NSE1 homolog, SMC5-SMC6 complex component	Homo sapiens	97-101
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	NSE1 homolog, SMC5-SMC6 complex component	Homo sapiens	97-101
29058176-3	2018	The activation/phosphorylation of some proteins including Zn2+-transporter ZIP7 in cardiomyocytes is controlled with CK2alpha, thereby, inducing changes in the level of intracellular free Zn2+ ([Zn2+] i ).	Zinc	58-62	solute carrier family 39 member 7	Homo sapiens	75-79
29058176-3	2018	The activation/phosphorylation of some proteins including Zn2+-transporter ZIP7 in cardiomyocytes is controlled with CK2alpha, thereby, inducing changes in the level of intracellular free Zn2+ ([Zn2+] i ).	Zinc	188-192	solute carrier family 39 member 7	Homo sapiens	75-79
29414090-2	2018	The excellent performance of the sensor comes from simultaneously fabricated layer by layer structure "target DNA + Hemin / Au-Luminol NPs / DNA* / sl DNA / TGA / QDs / MWNTs / GCE" mode which was based on the enhancing effect of luminol by G-quadruplex / hemin and Au nanoparticles and the quenching effect of CdSe/ZnS by G-quadruplex / hemin.	Zinc	316-319	T-box transcription factor 1	Homo sapiens	157-160
29281262-0	2018	Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays.	Zinc	11-17	neurotrophic receptor tyrosine kinase 1	Homo sapiens	21-50
30613975-4	2019	Furthermore, the increased [Zn2+ ]i induced a significant increase in messenger RNA (mRNA) level of beta3 -AR in cardiomyocytes.	Zinc	28-32	ferredoxin reductase	Rattus norvegicus	107-109
30613975-9	2019	Overall, our present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn2+ ]i pathways.	Zinc	229-233	ferredoxin reductase	Rattus norvegicus	83-85
31259339-7	2019	Furthermore, we explore the stabilities and mechanical properties of tetr- and hex-W2B2 and indicate that they may be prepared by growing on ZnS(100) and ZnS(111), respectively.	Zinc	141-144	hematopoietically expressed homeobox	Homo sapiens	79-82
31259339-7	2019	Furthermore, we explore the stabilities and mechanical properties of tetr- and hex-W2B2 and indicate that they may be prepared by growing on ZnS(100) and ZnS(111), respectively.	Zinc	154-157	hematopoietically expressed homeobox	Homo sapiens	79-82
30645027-4	2019	Interestingly, the band alignments, exposure of active sites, and interfacial charge separation of Cd1- x Znx S@O-MoS2 /NiOx are optimized by tuning the Zn-doping content as well as the growth of defect-rich O-MoS2 layer and NiOx nanoparticles, which endow the hybrids with excellent HER performances.	Zinc	106-108	CD1c molecule	Homo sapiens	99-102
31252587-0	2019	Effective Modulation of Optical and Photoelectrical Properties of SnS2 Hexagonal Nanoflakes via Zn Incorporation.	Zinc	96-98	sodium voltage-gated channel alpha subunit 11	Homo sapiens	66-70
31252587-3	2019	Herein, we report the synthesis of SnS2 nanoflakes with Zn doping via simple hydrothermal route.	Zinc	56-58	sodium voltage-gated channel alpha subunit 11	Homo sapiens	35-39
31252587-4	2019	The effect of doping Zn was found to display a huge influence in the structural and crystalline order of as synthesized SnS2.	Zinc	21-23	sodium voltage-gated channel alpha subunit 11	Homo sapiens	120-124
31252587-5	2019	Their optical properties attest Zn doping of SnS2 results in reduction of the band gap which benefits strong visible-light absorption.	Zinc	32-34	sodium voltage-gated channel alpha subunit 11	Homo sapiens	45-49
30738010-10	2019	GPR39 is expressed on intestinal L- and K-cells, and stimulated GIP secretion plays an integral role in mediating enhanced insulin secretion and glucose tolerance following oral administration of Zn2+.	Zinc	196-200	G protein-coupled receptor 39	Mus musculus	0-5
31086870-6	2019	To better understand the Mn import pathway in skeletal muscle cells, we probed the functional relevance of the closely related proteins ZIP8 and ZIP14, which are implicated in Zn, Mn, and Fe transport.	Zinc	176-178	solute carrier family 39 member 8	Homo sapiens	136-140
31086870-6	2019	To better understand the Mn import pathway in skeletal muscle cells, we probed the functional relevance of the closely related proteins ZIP8 and ZIP14, which are implicated in Zn, Mn, and Fe transport.	Zinc	176-178	solute carrier family 39 member 14	Homo sapiens	145-150
31001120-7	2019	Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. In vivo study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.	Zinc	308-310	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	29-33
31001120-7	2019	Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. In vivo study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.	Zinc	308-310	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	44-48
31001120-7	2019	Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. In vivo study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.	Zinc	308-310	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	44-48
31001120-7	2019	Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. In vivo study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.	Zinc	308-310	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	44-48
31458706-1	2018	This work uniquely reports the synthesis of Zn x Mg1-x O nanowires and submicron columns by utilizing a traditional carbothermal reduction process toward forming ZnO nanowire ultraviolet detectors, while simultaneously utilizing Mg3N2 as the source of Mg.	Zinc	44-46	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	49-52
32363330-7	2020	Our optimized procedure was employed for the successful growth of Zn x Mg1-x Se shells around In(Zn)P QDs.	Zinc	66-68	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	71-74
30772605-2	2019	The amide derivatives 5a-f showed moderate potency against GSK-3beta with weak Cu2+, Zn2+ and Al3+ chelating ability.	Zinc	85-89	glycogen synthase kinase 3 alpha	Homo sapiens	59-68
32320662-4	2020	NC-Zn2+ ejection reverses the HIV-1 blockade on SG assembly, inhibits NC-SG assembly, disrupts NC/Gag-genomic RNA (vRNA) ribonucleoprotein complexes, and causes nuclear sequestration of NC and the vRNA, inhibiting Gag expression and virus release.	Zinc	3-7	Pr55(Gag)	Human immunodeficiency virus 1	98-101
30935087-11	2019	Nut consumers were less likely to be below the EAR for vitamins A, B1, B2, B6, C, D, E, folic acid, and Ca, Mg, Se and Zn than non-nut consumers.	Zinc	119-121	NUT midline carcinoma family member 1	Homo sapiens	0-3
32320662-4	2020	NC-Zn2+ ejection reverses the HIV-1 blockade on SG assembly, inhibits NC-SG assembly, disrupts NC/Gag-genomic RNA (vRNA) ribonucleoprotein complexes, and causes nuclear sequestration of NC and the vRNA, inhibiting Gag expression and virus release.	Zinc	3-7	Pr55(Gag)	Human immunodeficiency virus 1	214-217
29704071-7	2018	zone to eta phase is a growing process where Mg and Zn atoms enter the nanoparticle, therefore rejecting Al atoms.	Zinc	52-54	endothelin receptor type A	Homo sapiens	8-11
32326581-3	2020	In addition, it is possible to tune the CdTe bandgap by introducing, for example, Zn into the composition, forming Cd1-xZnxTe alloys, which can fulfill the Shockley-Queisser limit design criteria for tandem devices.	Zinc	82-84	CD1c molecule	Homo sapiens	115-118
29651652-4	2018	The maximum sorption capacities observed were higher for the ST20-ALG composite compared to the initial ST20 oxide for all studied metal ions, namely their values for ST20-ALG were 22.44 mg g- 1 for Cu(II) adsorption, 19.95 mg g- 1 for Zn(II), 18.85 mg g- 1 for Cd(II), and 32.49 mg g- 1 for Pb(II).	Zinc	236-238	suppressor of tumorigenicity 20	Homo sapiens	61-65
30562656-1	2019	In this study, various sonochemical conditions were applied to prepare the microsheets, nanosheets and nanoflowers of a metal-organic framework (MOF; [Zn6(IDC)4(OH)2(Hprz)2]n) that is composed of Zn(II) cations coordinated with the linear N-donor piperazine (prz) and rigid planar imidazole-4,5-dicarboxylate (H3IDC) ligands.	Zinc	151-153	lysine acetyltransferase 8	Homo sapiens	145-148
30562660-1	2019	Micro-scale zinc-copper (mZn/Cu) bimetallic particles were prepared via precipitating Cu on the surface of Zn and were for the first time applied in the aniline degradation.	Zinc	26-28	mitochondrial calcium uniporter	Mus musculus	86-88
31780293-2	2020	Ag2S QDs were synthesized with bead-chain-like structure by the self-assembly route and further covalently bound with ZnS QDs to be coated onto the indium tin oxide (ITO) electrodes.	Zinc	118-121	angiotensin II receptor type 1	Homo sapiens	0-4
30853849-3	2019	The binding thermodynamics of Mg2+ to RNH was determined using competition ITC experiments, and the binding affinity of Mg2+ was found to be about 40- and 400-times lower than those of Mn2+ and of Zn2+, respectively.	Zinc	197-201	mucin 7, secreted	Homo sapiens	30-33
30520657-3	2019	As for other ions and solutes, Zn2+ is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins.	Zinc	31-35	unzipped	Drosophila melanogaster	107-110
30520657-4	2019	ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn2+ import.	Zinc	131-135	solute carrier family 39 (zinc transporter), member 4-like	Rattus norvegicus	0-5
30500420-8	2019	Allicin stimulated the immune response by causing Zn2+ release from proteins and increasing the Zn2+-dependent IL-1-triggered production of IL-2 in murine EL-4 T-cells.	Zinc	96-100	interleukin 1 complex	Mus musculus	111-115
30654594-4	2019	%), the time taken by the alloy to achieve the peak hardness value gradually increases aging at 120  C. When the Zn/Mg ratio is in the range from 2.27% to 2.62%, the precipitate phase of the alloy after peak-aged is mainly dominated by smaller disc-like eta" phase and GP I (Guinier Preston) zones, the grain boundary precipitates are slender and continuous and the PFZ (precipitate free zones) is narrow.	Zinc	113-115	endothelin receptor type A	Homo sapiens	254-257
30654594-4	2019	%), the time taken by the alloy to achieve the peak hardness value gradually increases aging at 120  C. When the Zn/Mg ratio is in the range from 2.27% to 2.62%, the precipitate phase of the alloy after peak-aged is mainly dominated by smaller disc-like eta" phase and GP I (Guinier Preston) zones, the grain boundary precipitates are slender and continuous and the PFZ (precipitate free zones) is narrow.	Zinc	113-115	glucose-6-phosphate isomerase	Homo sapiens	269-273
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	endothelin receptor type B	Rattus norvegicus	79-105
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	endothelin receptor type B	Rattus norvegicus	107-110
30150024-2	2018	The synthesized MOF [Zn(BDC)(DMF)] crystal was characterized by PXRD, FTIR, FESEM-EDX, TGA, UV-DRS and BET.	Zinc	21-23	T-box transcription factor 1	Homo sapiens	87-90
30150024-2	2018	The synthesized MOF [Zn(BDC)(DMF)] crystal was characterized by PXRD, FTIR, FESEM-EDX, TGA, UV-DRS and BET.	Zinc	21-23	delta/notch like EGF repeat containing	Homo sapiens	103-106
30500804-4	2018	Among them, 1% Ag2S/ZnO/ZnS showed a mixed structure of nano-line and nano-particle, of which BET value increased significantly, and the morphology was more excellent.	Zinc	24-27	angiotensin II receptor type 1	Homo sapiens	15-19
30500804-6	2018	Meanwhile, 1% Ag2S/ZnO/ZnS also showed a good degradation effect on other dyes with different structures, and its degradation efficiency did not change significantly after three cycles, showing certain stability.	Zinc	23-26	angiotensin II receptor type 1	Homo sapiens	14-18
30155930-3	2018	Zn and Cd-MOFs lead to the derivation of porous carbons (PCs), which exhibit remarkable BET specific surface areas.	Zinc	0-2	delta/notch like EGF repeat containing	Homo sapiens	88-91
30256966-12	2018	Interestingly, tumor necrosis factor alpha (TNFalpha) levels were decreased during P3 (P = 0.04) in Zn relative to Ctl-fed pigs.	Zinc	100-102	tumor necrosis factor	Sus scrofa	15-42
30256966-12	2018	Interestingly, tumor necrosis factor alpha (TNFalpha) levels were decreased during P3 (P = 0.04) in Zn relative to Ctl-fed pigs.	Zinc	100-102	tumor necrosis factor	Sus scrofa	44-52
30256966-14	2018	In summary, Zn reduced TNFalpha (regardless of HS), and the stimulatory effect of HS on insulin secretion is amplified during HS recovery.	Zinc	12-14	tumor necrosis factor	Sus scrofa	23-31
30235829-1	2018	The long distance transport of Fe and Zn in the phloem sap of wheat (Triticum aestivum L.) is the key route for seed supply, due to wheat having a xylem discontinuity.	Zinc	38-40	thiosulfate sulfurtransferase 16, chloroplastic	Triticum aestivum	55-58
30235829-2	2018	To date, our knowledge is limited on Fe and Zn homeostasis in the phloem sap during the reproductive and grain filling stages.	Zinc	44-46	thiosulfate sulfurtransferase 16, chloroplastic	Triticum aestivum	73-76
30235829-7	2018	There was also a significant decrease in K, Fe and Zn phloem sap concentration of 1.5-, 1.4- and 1.1-fold, respectively, from the start of peak grain loading to the end of grain loading.	Zinc	51-53	thiosulfate sulfurtransferase 16, chloroplastic	Triticum aestivum	61-64
30159555-7	2018	To address these challenges, we applied chiral vibrational sum frequency generation (SFG) spectroscopy to probe the sp1 zinc finger (ZnF), a 31-amino acid protein, folding into a beta-hairpin/alpha-helix (betabetaalpha) motif upon binding to Zn2+.	Zinc	242-246	zinc finger protein 763	Homo sapiens	133-136
30159555-10	2018	The chiral SFG spectra show that interfacial crowding in the absence of spacer lipid hinders ZnF from folding into the betabetaalpha structure even in the presence of Zn2+.	Zinc	167-171	zinc finger protein 763	Homo sapiens	93-96
30133280-2	2018	This nondeliquescent compound features a cubic closet packing of the (PS4)3- groups, with Zn2+ filling in three-quarters of the tetrahedral interspaces.	Zinc	90-94	taste 2 receptor member 18 pseudogene	Homo sapiens	70-73
29882183-8	2018	AtCAX5-transformed yeasts displayed an increment in [Ca2+]int, [K+]int, [Na+]int, and [Zn2+]int concentration under the presence of both sinusoidal and square-waved EMF stresses compared to the control group, which shows that AtCAX5 expressed in the vacuole play an important role in maintaining the homeostasis of intracellular cations.	Zinc	87-91	cation exchanger 5	Arabidopsis thaliana	0-6
29730553-5	2018	Although SB interacts with Zn2+ ions which causes inference in the determination of Cr3+ ions however the interferent can be easily masked with SCN- ions.	Zinc	27-31	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	84-87
29916687-2	2018	The resulting nanoscale metal-organic framework (MOF) {Zn2(OPE-TC1)} n (NMOF-1) showed a vesicular morphology and permanent porosity with omniphilic pore surface.	Zinc	55-58	lysine acetyltransferase 8	Homo sapiens	24-53
29414441-7	2018	Analysis of a PKCdelta structural model revealed a potential His-Cys3 zinc-binding domain adjacent to residue Thr505 and suggests that interaction with a Zn2+ ion may preclude phosphorylation at this site.	Zinc	154-158	protein kinase C delta	Homo sapiens	14-22
29545819-0	2018	AtHMA4 Drives Natural Variation in Leaf Zn Concentration of Arabidopsis thaliana.	Zinc	40-42	heavy metal atpase 4	Arabidopsis thaliana	0-6
29545819-2	2018	Here, we report that genetic variation in Heavy Metal-ATPase 4 (HMA4) controls natural variation in leaf Zn content.	Zinc	105-107	heavy metal atpase 4	Arabidopsis thaliana	64-68
29545819-4	2018	Both quantitative trait loci (QTL) analysis and bulked segregant analysis (BSA) identified HMA4 as a strong candidate accounting for this variation in leaf Zn concentration.	Zinc	156-158	heavy metal atpase 4	Arabidopsis thaliana	91-95
29545819-6	2018	Sequence analysis revealed that a 1-bp deletion in the third exon of HMA4 from Fab-2 is responsible for the lose of function of HMA4 driving the low Zn observed in Fab-2.	Zinc	149-151	heavy metal atpase 4	Arabidopsis thaliana	69-73
29545819-6	2018	Sequence analysis revealed that a 1-bp deletion in the third exon of HMA4 from Fab-2 is responsible for the lose of function of HMA4 driving the low Zn observed in Fab-2.	Zinc	149-151	heavy metal atpase 4	Arabidopsis thaliana	128-132
29545819-9	2018	In addition, we also observed that Fab-2, Van-0 and the hma4-2 null mutant in the Col-0 background show enhanced resistance to a combination of high Zn and high Cd in the growth medium, raising the possibility that variation at HMA4 may play a role in environmental adaptation.	Zinc	149-151	heavy metal atpase 4	Arabidopsis thaliana	56-60
29058176-9	2018	Therefore, our present data demonstrated, for the first time, the physiological relevance of CK2alpha in cellular control of Zn2+-distribution via inducing ZIP7 phosphorylation and activation of these above endogenous actors in hyperglycemia/diabetes-associated cardiac dysfunction.	Zinc	125-129	solute carrier family 39 member 7	Homo sapiens	156-160
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-149
31780293-3	2020	It was discovered that the ZnS@Ag2S-modified electrodes could display the visible-light-driven PEC behavior, of which Ag2S and ZnS QDs could act as the PEC sensitizer and Hg2+-recognition probe, respectively.	Zinc	27-30	angiotensin II receptor type 1	Homo sapiens	31-35
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A8	Homo sapiens	111-117
31780293-3	2020	It was discovered that the ZnS@Ag2S-modified electrodes could display the visible-light-driven PEC behavior, of which Ag2S and ZnS QDs could act as the PEC sensitizer and Hg2+-recognition probe, respectively.	Zinc	27-30	angiotensin II receptor type 1	Homo sapiens	118-122
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A8	Homo sapiens	135-150
29654524-5	2018	This receptor exhibit more selectivity and sensitivity towards Cr3+ than other divalent and trivalent cations like Mn2+, Zn2+, Co2+, Ni2+, Cd2+, Cu2+, Hg2+, Fe3+, and Al3+ ions.	Zinc	121-125	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	63-66
31780293-3	2020	It was discovered that the ZnS@Ag2S-modified electrodes could display the visible-light-driven PEC behavior, of which Ag2S and ZnS QDs could act as the PEC sensitizer and Hg2+-recognition probe, respectively.	Zinc	127-130	angiotensin II receptor type 1	Homo sapiens	31-35
29124566-9	2018	Zn2+ enhanced the phosphorylation of p38-mitogen-activated protein kinase (MAPK) at 1-6 h after LPS treatment.	Zinc	0-4	mitogen activated protein kinase 14	Rattus norvegicus	37-73
31780293-4	2020	More importantly, the photocurrent responses of the developed electrodes could be specifically turned on in the presence of Hg2+ under the visible-light irradiation, presumably due to that Hg2+ might conduct a Zn-to-Hg exchange on ZnS QDs to trigger the formation of HgS/ZnS@Ag2S heterojunction towards the enhanced electron-hole separation.	Zinc	210-212	angiotensin II receptor type 1	Homo sapiens	275-279
29124566-9	2018	Zn2+ enhanced the phosphorylation of p38-mitogen-activated protein kinase (MAPK) at 1-6 h after LPS treatment.	Zinc	0-4	mitogen activated protein kinase 14	Rattus norvegicus	75-79
31780293-4	2020	More importantly, the photocurrent responses of the developed electrodes could be specifically turned on in the presence of Hg2+ under the visible-light irradiation, presumably due to that Hg2+ might conduct a Zn-to-Hg exchange on ZnS QDs to trigger the formation of HgS/ZnS@Ag2S heterojunction towards the enhanced electron-hole separation.	Zinc	231-234	angiotensin II receptor type 1	Homo sapiens	275-279
29124566-11	2018	Intracellular Zn2+ chelation with N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) or inhibition of p38-MAPK diminished the Zn2+ enhancement of LPS-induced NO production.	Zinc	14-18	mitogen activated protein kinase 14	Rattus norvegicus	113-117
29124566-11	2018	Intracellular Zn2+ chelation with N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) or inhibition of p38-MAPK diminished the Zn2+ enhancement of LPS-induced NO production.	Zinc	133-137	mitogen activated protein kinase 14	Rattus norvegicus	109-112
28290146-0	2018	Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism.	Zinc	124-126	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-16
28290146-2	2018	The present study aimed to explore the role of COX-2 in Zn-induced Parkinsonism and its association with the microglial activation.	Zinc	56-58	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	47-52
28290146-8	2018	Zn induced time-dependent increase in the expression of COX-2 while COX-1 expression was unaltered.	Zinc	0-2	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	56-61
28290146-9	2018	Zn reduced the neurobehavioral activities, striatal dopamine content, tyrosine hydroxylase (TH) expression and number of dopaminergic neurons.	Zinc	0-2	tyrosine hydroxylase	Rattus norvegicus	70-90
29124566-11	2018	Intracellular Zn2+ chelation with N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) or inhibition of p38-MAPK diminished the Zn2+ enhancement of LPS-induced NO production.	Zinc	133-137	mitogen activated protein kinase 14	Rattus norvegicus	113-117
29124566-12	2018	These findings suggest that activation of MAPK and NFkappaB is important for mediating Zn2+enhancement of LPS-induced NO production in astrocytes.	Zinc	87-91	mitogen activated protein kinase 14	Rattus norvegicus	42-46
31780293-4	2020	More importantly, the photocurrent responses of the developed electrodes could be specifically turned on in the presence of Hg2+ under the visible-light irradiation, presumably due to that Hg2+ might conduct a Zn-to-Hg exchange on ZnS QDs to trigger the formation of HgS/ZnS@Ag2S heterojunction towards the enhanced electron-hole separation.	Zinc	271-274	angiotensin II receptor type 1	Homo sapiens	275-279
32080916-3	2020	However, it is found that the structural stability can be substantially improved by the mixed occupation of Na+ /Zn2+ at both M1 and M2 when using NaV2 (PO4 )3 (NVP) as a cathode for Zn-ion batteries.	Zinc	113-117	neuron navigator 2	Homo sapiens	147-151
29194809-3	2018	For the first time 25 new transition metal complexes (Mn2+ , Ni2+ , Co2+ , Cu2+ , and Zn2+ ) using methylsemicarbazide (1) as the ligand were prepared and comprehensively analyzed by, for example, XRD, IR, EA, UV/Vis and DSC/DTA/TGA.	Zinc	86-90	desmocollin 3	Homo sapiens	221-224
29194809-3	2018	For the first time 25 new transition metal complexes (Mn2+ , Ni2+ , Co2+ , Cu2+ , and Zn2+ ) using methylsemicarbazide (1) as the ligand were prepared and comprehensively analyzed by, for example, XRD, IR, EA, UV/Vis and DSC/DTA/TGA.	Zinc	86-90	T-box transcription factor 1	Homo sapiens	229-232
29440746-8	2018	Furthermore, using an Ni wire-implanted mouse model, we found that Ni wire-induced expression of mouse macrophage inflammatory protein-2 (MIP-2) and cyclooxygenase-2 (COX-2) mRNA in the skin tissue surrounding the wire were enhanced by low Zn conditions.	Zinc	240-242	prostaglandin-endoperoxide synthase 2	Mus musculus	149-165
29440746-8	2018	Furthermore, using an Ni wire-implanted mouse model, we found that Ni wire-induced expression of mouse macrophage inflammatory protein-2 (MIP-2) and cyclooxygenase-2 (COX-2) mRNA in the skin tissue surrounding the wire were enhanced by low Zn conditions.	Zinc	240-242	prostaglandin-endoperoxide synthase 2	Mus musculus	167-172
29373588-4	2018	Supplemental organic Zn increased bone Zn and Mg content, serum IGF-1, growth hormone and leptin concentration.	Zinc	21-23	growth hormone	Gallus gallus	71-85
32080916-3	2020	However, it is found that the structural stability can be substantially improved by the mixed occupation of Na+ /Zn2+ at both M1 and M2 when using NaV2 (PO4 )3 (NVP) as a cathode for Zn-ion batteries.	Zinc	113-115	neuron navigator 2	Homo sapiens	147-151
31874288-8	2020	In general, the growth hormone (Gh)/insulin-like growth factor-I (Igf-1) axis is important for growth in fishes, and Zn exposure induced a significant reduction of igf-1 expression at the concentration that caused growth inhibition.	Zinc	117-119	insulin-like growth factor 1	Danio rerio	66-71
29308896-1	2018	A Zn(II)-based fluorescent metal-organic framework (MOF) was synthesized and applied as a highly sensitive and quickly responsive chemical sensor for antibiotic detection in simulated wastewater.	Zinc	2-8	lysine acetyltransferase 8	Homo sapiens	27-56
29283372-9	2017	Curcumin-Cu(II) or -Zn(II) complexes systems significantly enhanced the superoxide dismutase, catalase, and glutathione peroxidase activities and attenuated the increase of malondialdehyde levels and caspase-3 and caspase-9 activities, in a dose-dependent manner.	Zinc	19-26	caspase 3	Rattus norvegicus	200-209
31874288-8	2020	In general, the growth hormone (Gh)/insulin-like growth factor-I (Igf-1) axis is important for growth in fishes, and Zn exposure induced a significant reduction of igf-1 expression at the concentration that caused growth inhibition.	Zinc	117-119	insulin-like growth factor 1	Danio rerio	164-169
32178414-5	2020	The number of fluorophores available for Zn(II) increased from pH 3 to 7 by ~44%.	Zinc	41-47	phenylalanine hydroxylase	Homo sapiens	63-65
28683540-3	2017	Thus, the main goal of this study was to develop composition-tunable and biocompatible Zn x Cd1 - x S QDs using carboxymethylcellulose polysaccharide as direct capping ligand via green colloidal aqueous route at neutral pH and at room temperature for potential biomedical and environmental applications.	Zinc	87-89	CD1c molecule	Homo sapiens	92-95
28683540-6	2017	The XRD results indicated that monophasic ternary alloyed Zn x Cd1 - x S nanocrystals were produced with homogenous composition of the core as evidenced by EELS and XPS analyses.	Zinc	58-60	CD1c molecule	Homo sapiens	63-66
28683540-7	2017	In addition, the absorption and emission optical properties of Zn x Cd1 - x S QDs were red shifted with increasing the amount of Cd2+ in the alloyed nanocrystals, which have also increased the quantum yield compared to pure CdS and ZnS nanoparticles.	Zinc	63-65	CD1c molecule	Homo sapiens	68-71
32178414-9	2020	A positive relationship was found between the fraction of accessible fluorophores and Zn(II) binding at pH 7 determined based on proton release (R = 0.91-0.97).	Zinc	86-92	phenylalanine hydroxylase	Homo sapiens	104-106
28683540-7	2017	In addition, the absorption and emission optical properties of Zn x Cd1 - x S QDs were red shifted with increasing the amount of Cd2+ in the alloyed nanocrystals, which have also increased the quantum yield compared to pure CdS and ZnS nanoparticles.	Zinc	232-235	CD1c molecule	Homo sapiens	68-71
29170618-1	2017	We report on the growth and characterization of optical quality multiple quantum well structures of Zn x Cd1-x Se/Zn x Cd y Mg1-x-y Se on an ultra-thin Bi2Se3/CdTe virtual substrate on c-plane Al2O3 (sapphire).	Zinc	100-102	CD1c molecule	Homo sapiens	105-108
28948272-0	2017	Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-beta4-16 peptide and Zn7-metallothionein-3.	Zinc	40-42	tubulin beta 3 class III	Homo sapiens	71-79
28948272-2	2017	The released Zn(ii) in turn binds to amyloid-beta4-16.	Zinc	13-19	tubulin beta 3 class III	Homo sapiens	45-53
28967744-1	2017	A new luminescent Zn(II)-based metal-organic framework (MOF), [Zn2(TPOM)(NDC)2] 3.5H2O (Zn-MOF; TPOM = tetrakis(4-pyridyloxymethylene)methane and H2ndc = 2,6-naphthalenedicarboxylic acid), was successfully synthesized by a hydrothermal reaction.	Zinc	18-24	lysine acetyltransferase 8	Homo sapiens	31-61
31972155-0	2020	Assessing Structural Determinants of Zn2+ Binding to Human HV1 via Multiple MD Simulations.	Zinc	37-41	hydrogen voltage gated channel 1	Homo sapiens	59-62
31972155-1	2020	Voltage-gated proton channels (HV1) are essential for various physiological tasks but are strongly inhibited by Zn2+ cations.	Zinc	112-116	hydrogen voltage gated channel 1	Homo sapiens	31-34
31972155-3	2020	However, the results have always been interpreted under the assumption that Zn2+ binds to monomeric HV1 despite evidence that HV1 expresses as a dimer and that the dimer has a higher affinity for zinc than the monomer and experimental data that suggest coordination in the dimer interface.	Zinc	76-80	hydrogen voltage gated channel 1	Homo sapiens	100-103
32014991-0	2020	Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase.	Zinc	125-127	DDB1 and CUL4 associated factor 4	Homo sapiens	41-46
28711829-6	2017	Concentrations of Cu, Zn and Pb were also increased in manure treated soil and positive correlated with the relative abundance of intI1 and most of the ARGs.	Zinc	22-24	arginyl-tRNA synthetase	Glycine max	152-156
31940246-6	2020	Zn chelator TPEN treatment reduced the expression of stem cell markers CD73, CD90 and CD105 and generated ROS in endometrial stromal cells.	Zinc	0-2	5'-nucleotidase ecto	Homo sapiens	71-75
31881218-0	2020	Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration.	Zinc	0-4	mitochondrial calcium uniporter	Mus musculus	23-54
28957153-8	2017	The PL spectrum of ZnS:Mn/ZnO/GaN covers the visible region from the blue light to the red light (400-700 nm), and its color coordinate and color temperature are (0.3103,0.3063) and 6869 K, respectively, presenting strong white light emission.	Zinc	19-22	gigaxonin	Homo sapiens	30-33
31881218-4	2020	While studies have indicated that Zn2+ can also enter the mitochondria through the MCU, the specificity of the pore"s role in Zn2+-triggered injury is still debated.	Zinc	34-38	mitochondrial calcium uniporter	Mus musculus	83-86
31881218-6	2020	In cultured cortical neurons from MCU knockout mice, we find significantly reduced mitochondrial Zn2+ accumulation.	Zinc	97-101	mitochondrial calcium uniporter	Mus musculus	34-37
28805023-11	2017	The OPE-induced current was profoundly inhibited by 10 mum Zn2+ , the most potent Hv1 channel inhibitor, and was also inhibited by treatment with GF109203X, a specific protein kinase C (PKC) inhibitor.	Zinc	59-63	hydrogen voltage gated channel 1	Homo sapiens	82-85
31881218-11	2020	These data-combining both genetic and pharmacologic tools-support the hypothesis that Zn2+ entry through the MCU is a critical contributor to ischemic neurodegeneration that could be targeted for neuroprotection.	Zinc	86-90	mitochondrial calcium uniporter	Mus musculus	109-112
32068980-6	2020	In vivo, Cav2.3 must be under tight control by endogenous trace metal cations (Zn2+ and Cu2+).	Zinc	79-83	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	9-15
28538167-1	2017	Thermodynamic information about the metal-ligand interaction between Fe3+, Zn2+, Cu2+ and Sn2+, and a biodegradable ligand as MGDA is reported.	Zinc	75-79	paired box 6	Homo sapiens	126-130
32068980-11	2020	Surprisingly, Zn2+ plus histidine resembles the kainate only control with more seizure severity in Cav2.3-competent than in deficient mice.	Zinc	14-18	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	99-105
32068980-12	2020	CONCLUSION: Cav2.3 represents one important Zn2+-sensitive target, which is useful for modulating convulsive seizures.	Zinc	44-48	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	12-18
28758753-2	2017	Putting the chromophore, for which luminescence can be enhanced by Zn2+ ion, into MOF-5 by the "bottle around ship" strategy is a simple but efficient synthesis method to realize such dual-emissive materials.	Zinc	67-71	lysine acetyltransferase 8	Homo sapiens	82-85
28758753-3	2017	According to this strategy, a novel dual-emissive luminescent composite material [Zn2(HL)3]+@MOF-5 was constructed by loading the [La3(HL)2L2(NO3)3H2O] (1) (H2L = 7,7"-(ethane-1,1"-diyl)8-hydro-quinoline) into MOF-5, in which the [Zn2(HL)3]+ anions were transformed from 1 with the existence of Zn2+.	Zinc	295-299	lysine acetyltransferase 8	Homo sapiens	93-96
31841328-3	2020	Molecular docking predicted that RGM-(Hyp)-GF and the ACE residues of Glu384, His513 and Lys511 formed hydrogen-bonding interactions at distances of 2.57, 2.99 and 2.42+3.0 A. RGL-(Hyp)-GL formed hydrogen bonds with Lys511 and Tyr523 and generated hydrogen-bonding interactions with His387 and Glu411 in the zinc(II) complexation motif at distances of 2.74 and 3.03+1.93 A.	Zinc	308-316	angiotensin I converting enzyme	Bos taurus	54-57
28873533-4	2018	A free Zn concentration of 1.76mumolL-1 determined with DMT was in excellent agreement with the free Zn concentration independently provided by the electroanalytical technique Absence of Gradients and Nernstian Equilibrium Stripping (AGNES), 1.7mumolL-1, amounting to 14.4% of the total Zn.	Zinc	7-9	dematin actin binding protein	Homo sapiens	56-59
31645653-4	2020	This variant affects the conserved cysteine residue forming the coordinate bond with Zn2+ ion at the first zinc finger domain, and is predicted to exert a dominant-negative effect because of the generation of homo- and hetero-dimers with the wild-type and variant ZBTB7A proteins.	Zinc	85-89	zinc finger and BTB domain containing 7A	Homo sapiens	264-270
29180015-3	2018	Furthermore, we recently found that copper (Cu2+) significantly exacerbates Zn2+ neurotoxicity in mouse hypothalamic neuronal cells, suggesting that Zn2+ interaction with Cu2+ is important for the development of neurological disease.	Zinc	76-80	immunoglobulin kappa variable 1-35	Mus musculus	44-47
29180015-3	2018	Furthermore, we recently found that copper (Cu2+) significantly exacerbates Zn2+ neurotoxicity in mouse hypothalamic neuronal cells, suggesting that Zn2+ interaction with Cu2+ is important for the development of neurological disease.	Zinc	76-80	immunoglobulin kappa variable 1-35	Mus musculus	171-174
29180015-3	2018	Furthermore, we recently found that copper (Cu2+) significantly exacerbates Zn2+ neurotoxicity in mouse hypothalamic neuronal cells, suggesting that Zn2+ interaction with Cu2+ is important for the development of neurological disease.	Zinc	149-153	immunoglobulin kappa variable 1-35	Mus musculus	44-47
29180015-3	2018	Furthermore, we recently found that copper (Cu2+) significantly exacerbates Zn2+ neurotoxicity in mouse hypothalamic neuronal cells, suggesting that Zn2+ interaction with Cu2+ is important for the development of neurological disease.	Zinc	149-153	immunoglobulin kappa variable 1-35	Mus musculus	171-174
29180015-5	2018	Thus, in this study, we focused on organic acids and searched for compounds that inhibit Cu2+/Zn2+-induced neurotoxicity.	Zinc	94-98	immunoglobulin kappa variable 1-35	Mus musculus	89-92
28577345-3	2017	Herein three new MIR NLO materials, AZn4 Ga5 S12 (A=K, Rb, Cs) are reported, which crystallize in the KCd4 Ga5 S12 -type structure and adopt a 3D diamond-like framework (DLF) consisting of MS4 (M=Zn/Ga) tetrahedra; achieving the desired balance with strong powder SHG response (1.2-1.4 x AGS) and wide band gap (Eg  3.65 eV).	Zinc	37-39	MS4	Homo sapiens	189-192
28353208-3	2017	However, the receptor HL2 response toward Cd2+, Mg2+, Ba2+, Ca2+ besides Zn2+ and exhibits fluorescence enhancement but not enough to detection of the concentration levels of Zn2+.	Zinc	175-179	intelectin 2	Homo sapiens	22-25
29180015-10	2018	These results suggest that pyruvic acid prevents Cu2+/Zn2+-induced neuronal cell death by suppressing mitochondrial injury.	Zinc	54-58	immunoglobulin kappa variable 1-35	Mus musculus	49-52
31678720-6	2020	Both compounds inhibited Duox activity in normal human bronchial epithelial cells but with an IC50 over 10-fold higher than that reported for Hv1 (IC50 Zn2+ = 0.68 mM; IC50 ClGBI = 0.07-0.14 mM).	Zinc	152-155	hydrogen voltage gated channel 1	Homo sapiens	142-145
29289532-4	2018	Here, we identified a novel connection between CFTR/ENaC expression and the intracellular Zn2+ concentration in the regulation of MUC5AC, a major secreted mucin that is highly expressed in CF airway.	Zinc	90-94	LOC100508689	Homo sapiens	155-160
29114036-6	2017	Here we found that ZnT2 deletion in lactating mice and cultured MECs resulted in Zn2+-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development.	Zinc	81-85	prolactin receptor	Mus musculus	198-216
29180421-5	2017	Moreover, reduced intracellular Zn concentration in Slc39a10fl/fl;LysM-Cre+ macrophages led to the stabilization of p53, which increased apoptosis upon LPS stimulation.	Zinc	32-34	solute carrier family 39 (zinc transporter), member 10	Mus musculus	52-60
29180421-8	2017	Taken together, these results suggest that Slc39a10 plays a role in promoting the survival of macrophages through a Zn/p53-dependent axis in response to inflammatory stimuli.	Zinc	116-118	solute carrier family 39 (zinc transporter), member 10	Mus musculus	43-51
28557421-12	2017	Similarly, addition of Cu(I) to the Zn(II)-TTP-2D/RNA complex resulted in inhibition of RNA binding.	Zinc	36-38	ZFP36 ring finger protein	Homo sapiens	43-46
29745158-3	2017	Compared to elevation of the level of only Cd2+ or Zn2+, the seed germination rate under elevation of both Cd2+ and Zn2+ levels was enhanced significantly; O2-  generation rate, contents of H2O2 and MDA decreased; CAT, APX and MDAR activities increased in the last stage of Cd2+ and Zn2+ exposure.	Zinc	116-120	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	219-222
31491633-5	2019	The main mechanism by which Ca2+ inhibited the APA was by competing with Mg2+ and Zn2+ for the active sites of the enzyme.	Zinc	82-86	glutamyl aminopeptidase	Homo sapiens	47-50
29137232-8	2017	Using in situ hybridization and immunohistochemical analysis, the inverse correlation between miR-143 down-regulation and HK2 overexpression is documented in hyperplastic Zn-deficient esophagus, archived ESCC-bearing Zn-deficient esophagus, and human ESCC tissues.	Zinc	171-173	microRNA 143	Homo sapiens	94-101
29137232-8	2017	Using in situ hybridization and immunohistochemical analysis, the inverse correlation between miR-143 down-regulation and HK2 overexpression is documented in hyperplastic Zn-deficient esophagus, archived ESCC-bearing Zn-deficient esophagus, and human ESCC tissues.	Zinc	171-173	hexokinase 2	Homo sapiens	122-125
29137232-8	2017	Using in situ hybridization and immunohistochemical analysis, the inverse correlation between miR-143 down-regulation and HK2 overexpression is documented in hyperplastic Zn-deficient esophagus, archived ESCC-bearing Zn-deficient esophagus, and human ESCC tissues.	Zinc	217-219	microRNA 143	Homo sapiens	94-101
29137232-8	2017	Using in situ hybridization and immunohistochemical analysis, the inverse correlation between miR-143 down-regulation and HK2 overexpression is documented in hyperplastic Zn-deficient esophagus, archived ESCC-bearing Zn-deficient esophagus, and human ESCC tissues.	Zinc	217-219	hexokinase 2	Homo sapiens	122-125
28753206-7	2017	Consistent with the role of Zn2+, palmitate caused a rise in mitochondrial Zn2+, leading to Zn2+-dependent mitochondrial recruitment of Drp-1 (a protein that catalyses mitochondrial fission) and loss of mitochondrial membrane potential.	Zinc	28-32	collapsin response mediator protein 1	Homo sapiens	136-141
28753206-7	2017	Consistent with the role of Zn2+, palmitate caused a rise in mitochondrial Zn2+, leading to Zn2+-dependent mitochondrial recruitment of Drp-1 (a protein that catalyses mitochondrial fission) and loss of mitochondrial membrane potential.	Zinc	75-79	collapsin response mediator protein 1	Homo sapiens	136-141
28753206-7	2017	Consistent with the role of Zn2+, palmitate caused a rise in mitochondrial Zn2+, leading to Zn2+-dependent mitochondrial recruitment of Drp-1 (a protein that catalyses mitochondrial fission) and loss of mitochondrial membrane potential.	Zinc	75-79	collapsin response mediator protein 1	Homo sapiens	136-141
31491633-6	2019	Excessive S2- could reduce the APA by removing Zn2+ from the active sites of the enzyme.	Zinc	47-51	glutamyl aminopeptidase	Homo sapiens	31-34
28293755-2	2017	Zn inhibited pyruvate kinase uncompetitively with respect to the substrate PEP, and competitively with respect to ADP.	Zinc	0-2	prolyl endopeptidase	Homo sapiens	75-78
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	43-45	prolyl endopeptidase	Homo sapiens	202-205
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	heavy metal atpase 3	Arabidopsis thaliana	68-72
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	43-45	prolyl endopeptidase	Homo sapiens	401-404
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	76-80	prolyl endopeptidase	Homo sapiens	202-205
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	76-80	prolyl endopeptidase	Homo sapiens	401-404
28888859-6	2017	The concentrations of Hg, Cd, Pb, Zn, and Cu in which the ALP activity was half that of the control (EC50) were found to be 0.017, 0.021, 0.27, 1.30, and 1.36 muM, respectively.	Zinc	34-36	uncharacterized protein	Chlamydomonas reinhardtii	58-61
31862901-8	2019	The results support our hypothesis that alteration in the level of function of HMA3 is counterbalanced by the fine regulation of the Zn homeostasis gene network in roots of A. thaliana.	Zinc	133-135	heavy metal atpase 3	Arabidopsis thaliana	79-83
31842510-6	2019	Previous findings showed that zinc tetrasulfonatophenylporphyrin can bind galectin-3 with sub-micromolar affinity without disturbing lactose binding.	Zinc	30-64	galectin 3	Homo sapiens	74-84
29092635-9	2017	In addition, NaHS suppressed Zn2+-dependent activation of metal-responsive transcription factor-1 and induction of metallothionein gene expression.	Zinc	29-33	metal regulatory transcription factor 1	Homo sapiens	58-97
28965604-3	2017	Previous work had indicated a Zn2+-dependent upregulation of STAT1 mRNA in response to LPS and IFN-beta, potentially affecting STAT1-dependent downstream signaling upon pre-incubation with these agents.	Zinc	30-34	interferon beta 1	Homo sapiens	95-103
28965604-5	2017	The LPS- and IFN-beta-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn2+ with the membrane permeable chelator N,N,N",N"-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.	Zinc	103-107	interferon beta 1	Homo sapiens	13-21
27752920-10	2017	It is proposed that Zn and Se play an important role in DM2 pathogenesis.	Zinc	20-22	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	56-59
28235739-5	2017	The heavy metals associated to HMW-DOM fraction follows the order: Zn &gt; Cu &gt; Pb &gt;&gt; Cd ~ As ~ U.	Zinc	67-69	cilia and flagella associated protein 97	Homo sapiens	31-34
28235739-6	2017	The percentage fraction of metals bound to HMW-DOM respect to total metal content follows the order: Cu &gt;&gt; Pb &gt; Zn, Cd in agreement with humic substance binding ability (Irwing-William series).	Zinc	121-123	cilia and flagella associated protein 97	Homo sapiens	43-46
26995406-1	2017	The study aimed to investigate the role of NO and neuronal NO synthase (nNOS) in Zn-induced neurodegeneration.	Zinc	81-83	nitric oxide synthase 1	Homo sapiens	72-76
31591273-1	2019	The gene designated BAB_RS23470 in the Brucella abortus 2308 genome encodes an ortholog of the cation diffusion facilitator family protein EmfA which has been linked to resistance to Mn toxicity in Rhizobium etli A B. abortus emfA null mutant derived from strain 2308 displays increased sensitivity to elevated levels of Mn in the growth medium compared to the parent strain, but wild-type resistance to Fe, Mg, Zn, Cu, Co and Ni.	Zinc	412-414	cation diffusion facilitator family transporter	Brucella abortus 2308	20-27
26995406-5	2017	Zn caused time-dependent reduction in nitrite content and total/nNOS activity/expression.	Zinc	0-2	nitric oxide synthase 1	Homo sapiens	64-68
26995406-8	2017	While Zn elevated LPO content, it attenuated nitrite content, nNOS activity, and glutathione level along with the expression of TH and nNOS in SH-SY-5Y cells.	Zinc	6-8	nitric oxide synthase 1	Homo sapiens	62-66
26995406-8	2017	While Zn elevated LPO content, it attenuated nitrite content, nNOS activity, and glutathione level along with the expression of TH and nNOS in SH-SY-5Y cells.	Zinc	6-8	nitric oxide synthase 1	Homo sapiens	135-139
26995406-9	2017	7-NI further augmented Zn-induced changes in the cell viability, oxidative stress, and expression of TH and nNOS.	Zinc	23-25	nitric oxide synthase 1	Homo sapiens	108-112
28274089-4	2017	The HTS/CdS/CdSe/ZnS coupled to the CuS CE showed the highest power conversion efficiency eta (of 3.46%).	Zinc	17-20	endothelin receptor type A	Homo sapiens	90-93
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interleukin 4	Bos taurus	250-254
28951896-4	2017	Here we report a novel crystal structure of membrane type I MMP (MT1-MMP or MMP-14), which includes a small peptide bound at the catalytic Zn site via its C-terminus.	Zinc	139-141	matrix metallopeptidase 14	Homo sapiens	60-63
28951896-4	2017	Here we report a novel crystal structure of membrane type I MMP (MT1-MMP or MMP-14), which includes a small peptide bound at the catalytic Zn site via its C-terminus.	Zinc	139-141	matrix metallopeptidase 14	Homo sapiens	65-72
28951896-4	2017	Here we report a novel crystal structure of membrane type I MMP (MT1-MMP or MMP-14), which includes a small peptide bound at the catalytic Zn site via its C-terminus.	Zinc	139-141	matrix metallopeptidase 14	Homo sapiens	76-82
29057835-9	2017	We found a high release of hypothalamic TRH, which along with reduced MBH PPII activity, increased TSH levels in Zn-deficient pups independently of changes in TH concentration.	Zinc	113-115	thyrotropin releasing hormone	Rattus norvegicus	40-43
29245902-0	2017	COX-2 metabolic products, the prostaglandin I2 and F2alpha, mediate the effects of TNF-alpha and Zn2+ in stimulating the phosphorylation of Tau.	Zinc	97-101	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
29245902-3	2017	Specifically, we initially found that high level of Zn2+ upregulates the expression of COX-2 via stimulating the activity of TNF-alpha in a zinc transporter 3 (ZnT3)-dependent mechanism.	Zinc	52-56	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
28780297-9	2017	Furthermore, Zn induced phytochelatin (PC) and glutathione peroxidase (GPX) expression in GSH catabolism.	Zinc	13-15	glutathione peroxidase 2	Crassostrea gigas	47-69
28780297-9	2017	Furthermore, Zn induced phytochelatin (PC) and glutathione peroxidase (GPX) expression in GSH catabolism.	Zinc	13-15	glutathione peroxidase 2	Crassostrea gigas	71-74
28957153-4	2017	Due to the insertion of ZnO films, the diffraction peak intensity of ZnS:Mn in ZnS:Mn/ZnO/GaN is stronger than that of ZnS:Mn in ZnS:Mn/GaN, and the full width at half-maximum is smaller.	Zinc	69-72	gigaxonin	Homo sapiens	90-93
28957153-4	2017	Due to the insertion of ZnO films, the diffraction peak intensity of ZnS:Mn in ZnS:Mn/ZnO/GaN is stronger than that of ZnS:Mn in ZnS:Mn/GaN, and the full width at half-maximum is smaller.	Zinc	69-72	gigaxonin	Homo sapiens	136-139
28957153-4	2017	Due to the insertion of ZnO films, the diffraction peak intensity of ZnS:Mn in ZnS:Mn/ZnO/GaN is stronger than that of ZnS:Mn in ZnS:Mn/GaN, and the full width at half-maximum is smaller.	Zinc	79-82	gigaxonin	Homo sapiens	90-93
28973460-5	2017	Here, we provide evidence for the binding of two Zn2+ atoms to Pcf11, bound to separate zinc-binding domains located on each side of the Clp1 recognition region.	Zinc	49-53	Pcf11p	Saccharomyces cerevisiae S288C	63-68
31957297-1	2017	A new metal-organic framework (MOF), {Zn(oba)(3-bpdh)0.5 }   2 H2 O (1 Zn; oba=4,4"-oxybis(benzoic acid), 3-bpdh=N,N"-bis(1-pyridine-3-yl-ethylidene)hydrazine), was successfully assembled in a solvothermal system.	Zinc	38-40	lysine acetyltransferase 8	Homo sapiens	6-36
28557068-5	2017	Then, an investigation was carried out regarding the inhibitory effects caused by various metal ions (Fe2+ , Pb2+ , Cd2+ , Ag+ , and Zn2+ ) on G6PD enzyme activities, as per Beutler method at 340 nm under in vitro conditions.	Zinc	133-137	glucose-6-phosphate dehydrogenase	Rattus norvegicus	143-147
28395160-4	2017	The BET surface area and surface site density gradually increased with Zn substitution.	Zinc	71-73	delta/notch like EGF repeat containing	Homo sapiens	4-7
28630041-6	2017	Under diastolic conditions, the addition of pathophysiological concentrations of Zn2+ (&gt;=2 nm) caused dysregulated RyR2-channel openings.	Zinc	81-85	ryanodine receptor 2	Rattus norvegicus	118-122
28630041-7	2017	Our data also revealed that RyR2 channels are not the only SR Ca2+-permeable channels regulated by Zn2+ Elevating the cytosolic Zn2+ concentration to 1 nm increased the activity of the transmembrane protein mitsugumin 23 (MG23).	Zinc	128-132	ryanodine receptor 2	Rattus norvegicus	28-32
28630041-10	2017	In conclusion, these data suggest that dysregulated Zn2+ homeostasis alters the function of both RyR2 and MG23 and that both ion channels play a key role in diastolic SR Ca2+ leakage.	Zinc	52-56	ryanodine receptor 2	Rattus norvegicus	97-101
26995406-10	2017	The results obtained thus demonstrate that Zn inhibits nNOS that partially contributes to an increase in oxidative stress, which subsequently leads to the nigrostriatal dopaminergic neurodegeneration.	Zinc	43-45	nitric oxide synthase 1	Homo sapiens	55-59
28473060-12	2017	The RANKL/OPG ratio was similar between the control and OVX/T1DM+Zn groups, whereas it was higher in the OVX/T1DM group.	Zinc	65-67	TNF superfamily member 11	Rattus norvegicus	4-9
28473060-13	2017	In conclusion, Zn supplementation prevents bone alteration in chronic OVX/T1DM rats, as demonstrated by the reduced RANKL/OPG ratio and preservation of bone architecture.	Zinc	15-17	TNF superfamily member 11	Rattus norvegicus	116-121
28421781-8	2017	PIH Zn showed values of 1.36, and 0.99 mg Zn/100 g samples of "wheat with milk" and "wheat with honey", respectively, and increased availability of 75%.	Zinc	4-6	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	0-3
28421781-8	2017	PIH Zn showed values of 1.36, and 0.99 mg Zn/100 g samples of "wheat with milk" and "wheat with honey", respectively, and increased availability of 75%.	Zinc	42-44	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	0-3
28772589-1	2017	The present work was focused on the synthesis and characterization of hydroxyapatite doped with low concentrations of zinc (Zn:HAp) (0.01 &lt; xZn &lt; 0.05).	Zinc	124-126	reticulon 3	Homo sapiens	127-130
28772589-2	2017	The incorporation of low concentrations of Zn2+ ions in the hydroxyapatite (HAp) structure was achieved by co-precipitation method.	Zinc	43-47	reticulon 3	Homo sapiens	76-79
28772589-7	2017	Furthermore, the Energy Dispersive X-ray Analysis (EDAX) and XPS analyses showed that the elements Ca, P, O, and Zn were found in all the Zn:HAp samples suggesting that the synthesized materials were zinc doped hydroxyapatite, Ca10-xZnx(PO4)6(OH), with 0.01 &lt;= xZn &lt;= 0.05.	Zinc	113-115	reticulon 3	Homo sapiens	141-144
28772589-7	2017	Furthermore, the Energy Dispersive X-ray Analysis (EDAX) and XPS analyses showed that the elements Ca, P, O, and Zn were found in all the Zn:HAp samples suggesting that the synthesized materials were zinc doped hydroxyapatite, Ca10-xZnx(PO4)6(OH), with 0.01 &lt;= xZn &lt;= 0.05.	Zinc	138-140	reticulon 3	Homo sapiens	141-144
28013412-6	2017	In this work, we show, for the first time in a oncohematologic cell line, that inhibition of Hv1 channels by Zn2+ and the more selective blocker 2-(6-chloro-1H-benzimidazol-2-yl)guanidine (ClGBI) progressively decreases intracellular pH in resting conditions.	Zinc	109-113	hydrogen voltage gated channel 1	Homo sapiens	93-96
27750369-3	2017	ZnF motifs usually possess an exceptional specificity and high affinity towards Zn(II) ion to drive folding.	Zinc	80-86	zinc finger protein 763	Homo sapiens	0-3
27541797-8	2017	On the basis of the spectral studies, TGA and DFT data an octahedral geometry has been assigned for Co(II), Ni(II), square planar for Cu(II) and tetrahedral for Zn(II) complexes.	Zinc	161-167	T-box transcription factor 1	Homo sapiens	38-41
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interleukin 1 beta	Bos taurus	314-322
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interferon beta-2	Bos taurus	324-361
31069605-11	2019	OA + Fe and OA + Zn displayed significant decrease in DTH, NO, expression of IL-4, 5, 13, 17, toll-like receptor-2, nuclear factor-kappa B and tumor necrosis factor-alpha; serum IgE, COX-2, and 5-LOX.	Zinc	17-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	183-188
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	160-164	Janus kinase 2	Homo sapiens	48-62
31694210-7	2019	Normal BMP-2 and Runx2 transcriptions are observed in both Si-TCP and Zn-TCP scaffolds at the initial time point, as demonstrated by RT-qPCR.	Zinc	70-72	bone morphogenetic protein 2	Homo sapiens	7-12
31694210-8	2019	Moreover, the addition of both Si and Zn positively regulate the osteoprotegerin: receptor activator of nuclear factor k-beta ligand (OPG:RANKL) ratio at 21-days for Si-TCP and Zn-TCP scaffolds.	Zinc	38-40	TNF receptor superfamily member 11b	Homo sapiens	65-80
31694210-8	2019	Moreover, the addition of both Si and Zn positively regulate the osteoprotegerin: receptor activator of nuclear factor k-beta ligand (OPG:RANKL) ratio at 21-days for Si-TCP and Zn-TCP scaffolds.	Zinc	38-40	TNF receptor superfamily member 11b	Homo sapiens	134-137
31694210-8	2019	Moreover, the addition of both Si and Zn positively regulate the osteoprotegerin: receptor activator of nuclear factor k-beta ligand (OPG:RANKL) ratio at 21-days for Si-TCP and Zn-TCP scaffolds.	Zinc	177-179	TNF receptor superfamily member 11b	Homo sapiens	65-80
27917477-0	2017	The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2.	Zinc	72-75	transmembrane protein 163	Homo sapiens	29-33
27917477-2	2017	Here, we demonstrate that SV31 protein synthesized within a cell-free system binds Zn2+ and to a lower extent Ni2+ and Cu2+ ions.	Zinc	83-87	transmembrane protein 163	Homo sapiens	26-30
31694210-9	2019	These results demonstrate the effects of Si and Zn doped porous beta-TCP scaffolds on the upregulation of osteoblast marker gene expression including OPG, RANKL, BMP-2, and Runx2, indicating the role of trace elements on the effective regulation of late-stage osteoblast cell differentiation markers.	Zinc	48-50	TNF receptor superfamily member 11b	Homo sapiens	150-153
31694210-9	2019	These results demonstrate the effects of Si and Zn doped porous beta-TCP scaffolds on the upregulation of osteoblast marker gene expression including OPG, RANKL, BMP-2, and Runx2, indicating the role of trace elements on the effective regulation of late-stage osteoblast cell differentiation markers.	Zinc	48-50	bone morphogenetic protein 2	Homo sapiens	162-167
31652717-7	2019	The findings suggested that the HAp-coated Mg-10 wt% ZnO-2.5 h + 10 min composite is a high-potential candidate for biodegradable implant applications.	Zinc	53-56	reticulon 3	Homo sapiens	32-35
28090201-0	2016	The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.	Zinc	42-50	nerve growth factor	Rattus norvegicus	22-25
28090201-0	2016	The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.	Zinc	42-50	nerve growth factor	Rattus norvegicus	62-65
31552978-1	2019	A new white light MOF was constructed from low-cost 1,3,5-benzenetricarboxylate and nontoxic Zinc(ii) ions.	Zinc	93-101	lysine acetyltransferase 8	Homo sapiens	18-21
28090201-5	2016	The NGF-induced TrkA internalization was slightly inhibited in the presence of Cu2+ and Zn2+ ions, whereas the metal ions elicited the NGF(1-14)-induced internalization of TrkA and no significant differences were found in the weak Ac-NGF(1-14)-induced receptor internalization.	Zinc	88-92	nerve growth factor	Rattus norvegicus	4-7
31271795-6	2019	All three types of NC adsorbed significant amount of Fe, and CNC adsorbed significant amount of Zn, while no significant adsorption was observed on other minerals (Ca, Mg, Zn, Cu and Ag).	Zinc	96-98	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	61-64
27895481-2	2016	In this study, CdSe/ZnS QDs-based nonviral vectors with the dual functions of delivering miR-26a plasmid and bioimaging were formulated by capping the surface of CdSe/ZnS QDs with polyethyleneimine (PEI).	Zinc	20-23	microRNA 26a-1	Homo sapiens	89-96
27895481-3	2016	The PEI-coated QDs were capable of condensing miR-26a expression vector into nanocomplexes that can emit strong red luminescence when loaded with CdSe/ZnS QDs.	Zinc	151-154	microRNA 26a-1	Homo sapiens	46-53
27811086-0	2016	The ratio of Zn to Cd supply as a determinant of metal-homeostasis gene expression in tobacco and its modulation by overexpressing the metal exporter AtHMA4.	Zinc	13-15	heavy metal atpase 4	Arabidopsis thaliana	150-156
28791524-5	2017	The 5-FU@FACS-Mn:ZnS composite induced anti-proliferative properties in these organs as compared to the free 5-FU drug.	Zinc	17-20	acyl-CoA synthetase long-chain family member 1	Mus musculus	9-13
28686686-4	2017	Although Co2+ ions have been shown to protect the kidney via hypoxia inducible factor (HIF), the effect of Zn2+ ions on the induction of HIF1alpha, HIF2alpha and HIF3alpha has not been investigated previously.	Zinc	107-111	hypoxia inducible factor 3 subunit alpha	Rattus norvegicus	162-171
28595785-6	2017	Zn NPs showed dual effects, as its middle dose played protective role and recovered cardiac damages evidenced by significant reduction of serum cholesterol, HDL-cholesterol, lipoprotein (a), atherogenic index, TNF-alpha, cardiac MDA, B-type natriuretic peptide and caspase-3 activity.	Zinc	0-2	caspase 3	Rattus norvegicus	265-274
31165152-4	2019	Previously, we showed that ZmZIP5 functionally complemented the Zn uptake double mutant zrt1zrt2, Fe-uptake double mutant fet3fet4 in yeast.	Zinc	64-66	ferroxidase FET3	Saccharomyces cerevisiae S288C	122-130
27859307-1	2016	The sulfide photocatalyst of Zn0.9 Fe0.1 S was successfully synthesized by a facile microwave-assisted method, and Zn0.9 Fe0.1 S photocatalysts were characterized using SEM, EDX, XRD and BET.	Zinc	29-32	delta/notch like EGF repeat containing	Homo sapiens	187-190
27501363-7	2016	The Zn2+ -dependent mZnR/GPR39 activation triggers phosphorylation of extracellular regulated kinase and up-regulates expression of the chaperone protein clusterin (Clu).	Zinc	4-8	clusterin	Homo sapiens	154-163
27501363-7	2016	The Zn2+ -dependent mZnR/GPR39 activation triggers phosphorylation of extracellular regulated kinase and up-regulates expression of the chaperone protein clusterin (Clu).	Zinc	4-8	clusterin	Homo sapiens	165-168
27501363-8	2016	Importantly, neuronal Zn2+ -dependent extracellular regulated kinase1/2 phosphorylation and up-regulation of Clu are attenuated by silencing mZnR/GPR39 as well as by Abeta treatment.	Zinc	22-26	clusterin	Homo sapiens	109-112
28483530-5	2017	Herein, we demonstrated that Zn2+ could induce deglycosylation of lysosome-associated membrane protein 1 and 2 (LAMP-1 and LAMP-2), which primarily locate in late endosomes/lysosomes, in A549 lung epithelium cells.	Zinc	29-33	lysosomal associated membrane protein 1	Homo sapiens	66-110
28483530-5	2017	Herein, we demonstrated that Zn2+ could induce deglycosylation of lysosome-associated membrane protein 1 and 2 (LAMP-1 and LAMP-2), which primarily locate in late endosomes/lysosomes, in A549 lung epithelium cells.	Zinc	29-33	lysosomal associated membrane protein 1	Homo sapiens	112-118
27501363-11	2016	Synaptically released Zn2+ activates a Zn2+ -sensing receptor, mZnR/GPR39, and induces Ca2+ -signaling, followed by ERK1/2 MAPK activation and up-regulation of clusterin.	Zinc	22-26	clusterin	Homo sapiens	160-169
32055393-1	2019	In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.	Zinc	111-115	RNA 3'-terminal phosphate cyclase	Cricetulus griseus	183-187
26497033-6	2016	Zn caused neurobehavioral impairments and reduction in dopamine and its metabolites, tyrosine hydroxylase (TH)-positive neurons, catalase activity, and expression of TH, Bcl-2, and NOXA.	Zinc	0-2	tyrosine hydroxylase	Rattus norvegicus	85-105
26497033-6	2016	Zn caused neurobehavioral impairments and reduction in dopamine and its metabolites, tyrosine hydroxylase (TH)-positive neurons, catalase activity, and expression of TH, Bcl-2, and NOXA.	Zinc	0-2	tyrosine hydroxylase	Rattus norvegicus	107-109
28487400-0	2017	Native and engineered sensors for Ca2+ and Zn2+: lessons from calmodulin and MTF1.	Zinc	43-47	metal regulatory transcription factor 1	Homo sapiens	77-81
28487400-3	2017	Here we compare and contrast the native metal sensors: calmodulin (CaM), the quintessential Ca2+ sensor and metal-responsive transcription factor 1 (MTF1), a candidate Zn2+ sensor.	Zinc	168-172	metal regulatory transcription factor 1	Homo sapiens	149-153
31220319-8	2019	In the jejunum, an interaction of Zn source by challenge was observed for the expression of IL-8 (P = 0.001) and INF-gamma (P = 0.03), wherein the NE challenge upregulated their expression, but not in the Zn proteinate supplemented birds.	Zinc	34-36	interleukin 8-like 2	Gallus gallus	92-96
28318265-0	2017	Cytoskeletal-like Filaments of Ca2+-Calmodulin-Dependent Protein Kinase II Are Formed in a Regulated and Zn2+-Dependent Manner.	Zinc	105-109	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	31-74
28318265-4	2017	We discovered that CaMKII forms filaments that can extend for several micrometers in the presence of certain divalent cations (Zn2+, Cd2+, and Cu2+) but not with others (Ca2+, Mg2+, Co2+, and Ni2+).	Zinc	127-131	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	19-25
27684894-5	2016	Following a cisgenic approach to produce transgenic homozygous barley line over-expressing HvHMA2 in the transfer cells of the grain, resulted in a doubling of a wide range of nutrients including Zn, iron (Fe), and magnesium (Mg) in the inner endosperm.	Zinc	196-198	HMA2	Hordeum vulgare	91-97
31379409-8	2019	In addition, sublethal treatment with PAM induced phosphorylation of ATM kinase, accumulation of p53 protein, and expression of p21 and GADD45A, which are known p53 target genes, in a Zn2+-dependent manner.	Zinc	184-188	growth arrest and DNA damage inducible alpha	Homo sapiens	136-143
28318265-11	2017	We compile our results with structural and mechanistic data from the literature to propose a model of Zn2+-mediated CaMKII filament formation, in which assembly and activity are further regulated by Ca2+/CaM.	Zinc	102-106	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	116-122
27433833-4	2016	Herein, a tripeptide GGH was used to selectively chelate the Cu(2+) in Abeta-Cu complex in the presence of other metal ions (e.g., K(+), Ca(2+), Ni(2+), Mg(2+), and Zn(2+)) as shown by isothermal titration calorimetry results.	Zinc	165-167	gamma-glutamyl hydrolase	Rattus norvegicus	21-24
31140732-0	2019	Hierarchically Porous Co/Cox My (M = P, N) as an Efficient Mott-Schottky Electrocatalyst for Oxygen Evolution in Rechargeable Zn-Air Batteries.	Zinc	126-128	cytochrome c oxidase subunit 8A	Homo sapiens	25-28
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Zinc	109-111	insulin degrading enzyme	Bos taurus	78-81
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Zinc	162-165	insulin degrading enzyme	Bos taurus	78-81
28093242-2	2017	We show that Zn2+ acts via a specific receptor, ZnR/GPR39, to reduce fluid loss.	Zinc	13-17	G protein-coupled receptor 39	Mus musculus	52-57
28093242-8	2017	Altogether, our data indicate that Zn2+ acting via ZnR/GPR39 has a direct role in controlling Cl- absorption via upregulation of basolateral KCC1 in the colon.	Zinc	35-39	G protein-coupled receptor 39	Mus musculus	55-60
28093242-8	2017	Altogether, our data indicate that Zn2+ acting via ZnR/GPR39 has a direct role in controlling Cl- absorption via upregulation of basolateral KCC1 in the colon.	Zinc	35-39	solute carrier family 12, member 4	Mus musculus	141-145
28322340-5	2017	Further analysis indicate that Zn2+ induced ROS production, PARP-1 stimulation, increase in the [Ca2+]c and cell death, all of which were suppressed by chelerythrine, a protein kinase C inhibitor, DPI, a NADPH-dependent oxidase (NOX) inhibitor, GKT137831, a NOX1/4 inhibitor, and Phox-I2, a NOX2 inhibitor.	Zinc	31-35	NADPH oxidase 1	Homo sapiens	258-264
27425207-0	2016	Effect of Zn(2+) ions on the assembly of amylin oligomers: insight into the molecular mechanisms.	Zinc	10-16	islet amyloid polypeptide	Homo sapiens	41-47
31140732-7	2019	More importantly, the Co/Cox My +Pt/C achieves higher voltaic efficiency and several times longer cycle life than conventional RuO2 +Pt/C catalysts in rechargeable Zn-air batteries.	Zinc	164-166	cytochrome c oxidase subunit 8A	Homo sapiens	25-28
27425207-2	2016	Zn(2+) ions can bind to amylin peptides to form self-assembled Zn(2+)-amylin oligomers.	Zinc	0-2	islet amyloid polypeptide	Homo sapiens	24-30
27425207-2	2016	Zn(2+) ions can bind to amylin peptides to form self-assembled Zn(2+)-amylin oligomers.	Zinc	0-2	islet amyloid polypeptide	Homo sapiens	70-76
31237916-8	2019	Furthermore, our observations of ZnCd mixture effects at the individual and population levels are consistent with literature data on the dose-dependent expression of the cdf-2 gene, which is involved in mediation of Zn and Cd toxicity.	Zinc	33-35	Cation Diffusion Facilitator family	Caenorhabditis elegans	170-175
27425207-3	2016	In the current work the binding sites of Zn(2+) ions in the self-assembled amylin oligomers at various concentrations of zinc have been investigated.	Zinc	41-47	islet amyloid polypeptide	Homo sapiens	75-81
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
27425207-5	2016	First, in the absence of Zn(2+) ions polymorphic states (i.e. various classes of amylin oligomers) are obtained, but when Zn(2+) ions bind to amylin peptides to form Zn(2+)-amylin oligomers, the polymorphism is decreased, i.e. Zn(2+) ions bind only to specific classes of amylin.	Zinc	122-124	islet amyloid polypeptide	Homo sapiens	142-148
30444646-2	2019	Although the increased intracellular Zn2+ level ([Zn2+]i), oxidative stress, and altered cardiac matrix metalloproteinases (MMPs) in diabetic cardiomyopathy can intersect with different signaling pathways, the exact mechanisms are not known yet.	Zinc	37-41	matrix metallopeptidase 2	Rattus norvegicus	124-128
30444646-6	2019	Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8.	Zinc	18-22	solute carrier family 39 member 8	Rattus norvegicus	138-142
27230230-5	2016	Furthermore, carboxypeptidase B and alpha-amylase activities were significantly lower in samples with reduced pancreatic Zn contents.	Zinc	121-123	LOW QUALITY PROTEIN: pancreatic alpha-amylase	Sus scrofa	36-49
30444646-6	2019	Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8.	Zinc	53-57	solute carrier family 39 member 8	Rattus norvegicus	138-142
31089618-1	2019	Herein, a novel bifunctional flower-like metal-organic framework (MOF) was designed as a probe, which could be activated by H2S, induce itself disassembly and then release linker, Zn porphyrin.	Zinc	180-182	lysine acetyltransferase 8	Homo sapiens	41-70
27235274-1	2016	Solvolytic dissociation rate constants (kd) of bovine carbonic anhydrase II (CA) and its metallovariants (M-CAs, M=Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)) were estimated by a ligand substitution reaction, which was monitored by affinity capillary electrophoresis to selectively detect the undissociated CAs in the reaction mixture.	Zinc	139-145	carbonic anhydrase 2	Bos taurus	54-75
27235274-1	2016	Solvolytic dissociation rate constants (kd) of bovine carbonic anhydrase II (CA) and its metallovariants (M-CAs, M=Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)) were estimated by a ligand substitution reaction, which was monitored by affinity capillary electrophoresis to selectively detect the undissociated CAs in the reaction mixture.	Zinc	139-145	carbonic anhydrase 2	Bos taurus	77-79
28199205-5	2017	In addition to zinc transporters (ZnT) of the solute-carrier family type 30A (SLC30A), the lysosomal ion channel TRPML1 and the poorly understood novel transporter TMEM163 have been shown to play a role in the Zn2+ uptake by the lysosomes.	Zinc	210-214	transmembrane protein 163	Homo sapiens	164-171
28232787-4	2017	We examined the effects of other metal ions on the Zn2+-induced neurotoxicity in these cells and found that sub-lethal concentrations of copper ion (Cu2+) markedly exacerbated Zn2+-induced neurotoxicity.	Zinc	51-55	immunoglobulin kappa variable 1-35	Mus musculus	149-152
28232787-4	2017	We examined the effects of other metal ions on the Zn2+-induced neurotoxicity in these cells and found that sub-lethal concentrations of copper ion (Cu2+) markedly exacerbated Zn2+-induced neurotoxicity.	Zinc	176-180	immunoglobulin kappa variable 1-35	Mus musculus	149-152
28232787-7	2017	Thus, based on our results, we hypothesize here that Cu2+ interacts with Zn2+ in the synapse to synergistically promote neuronal death and significantly influence the pathogenesis of vascular dementia.	Zinc	73-77	immunoglobulin kappa variable 1-35	Mus musculus	53-56
27522493-5	2017	Although exposure to 8 mg L-1 Zn increased activities and mRNA levels of antioxidant enzymes during the early stage of exposure, including Cu/Zn-SOD, Mn-SOD, CAT, GPx and GR, the activities of these enzymes except Cu/Zn-SOD were inhibited at 96 h. Furthermore, a sharp increase in Nrf2 expression was observed in fish exposed to 8 mg L-1 at 6 and 12 h, and 2 mg L-1 at 12 h and 24 h, suggesting that Nrf2 was required for the protracted induction of these genes.	Zinc	30-32	catalase	Larimichthys crocea	158-161
27432995-6	2016	Using the Xenopus oocyte heterologous expression system and the two-microelectrode voltage-clamp technique, we find that the channel exhibits slow activation and inactivation kinetics, insensitivity to tetrodotoxin, and block by Cd(2+) and Zn(2+) These characteristics are reminiscent of CaV channels.	Zinc	240-242	caravaggio	Drosophila melanogaster	288-291
30979722-3	2019	Here, we show that ICA512 RESP18HD residues 91-131 encode for an intrinsically disordered region (IDR), which in vitro acts as a condensing factor for the reversible aggregation of insulin and other beta-cell proteins in a pH and Zn2+-regulated fashion.	Zinc	230-234	protein tyrosine phosphatase, receptor type, N	Rattus norvegicus	19-25
27297986-5	2016	In fact, surplus Zn enhanced the resistance of A. thaliana to fungal attack in Columbia (Col-0), Wassilewskija (WS), and mtp1-1.	Zinc	17-19	Cation efflux family protein	Arabidopsis thaliana	121-127
30979722-3	2019	Here, we show that ICA512 RESP18HD residues 91-131 encode for an intrinsically disordered region (IDR), which in vitro acts as a condensing factor for the reversible aggregation of insulin and other beta-cell proteins in a pH and Zn2+-regulated fashion.	Zinc	230-234	regulated endocrine-specific protein 18	Rattus norvegicus	26-32
25764516-8	2016	Zn attenuated the expression of tyrosine hydroxylase (TH) and vesicular monoamine transporter-2 (VMAT-2) while augmented the expression of dopamine transporter (DAT) and heme oxygenase-1 (HO-1).	Zinc	0-2	solute carrier family 6 member 3	Rattus norvegicus	139-159
30979722-4	2019	At variance with what has been shown for other granule cargoes with aggregating properties, the condensing activity of ICA512 RESP18HD is displayed at a pH close to neutral, i.e. in the pH range found in the early secretory pathway, whereas it is resolved at acidic pH and Zn2+ concentrations resembling those present in mature SGs.	Zinc	273-277	protein tyrosine phosphatase, receptor type, N	Rattus norvegicus	119-125
25764516-8	2016	Zn attenuated the expression of tyrosine hydroxylase (TH) and vesicular monoamine transporter-2 (VMAT-2) while augmented the expression of dopamine transporter (DAT) and heme oxygenase-1 (HO-1).	Zinc	0-2	solute carrier family 6 member 3	Rattus norvegicus	161-164
27886631-13	2017	All CRPs are able to confer Cd-tolerance, and four of them confer Zn-tolerance in the Zn-sensitive zrc1Delta yeast mutant.	Zinc	66-68	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	99-103
27886631-13	2017	All CRPs are able to confer Cd-tolerance, and four of them confer Zn-tolerance in the Zn-sensitive zrc1Delta yeast mutant.	Zinc	86-88	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	99-103
30979722-4	2019	At variance with what has been shown for other granule cargoes with aggregating properties, the condensing activity of ICA512 RESP18HD is displayed at a pH close to neutral, i.e. in the pH range found in the early secretory pathway, whereas it is resolved at acidic pH and Zn2+ concentrations resembling those present in mature SGs.	Zinc	273-277	regulated endocrine-specific protein 18	Rattus norvegicus	126-132
31193510-4	2019	The XRD structure revealed that Zn ion incorporation up to 10% led to the second phase hydroxyapatite (HAp) formation, while higher concentration diminished the apatite structure.	Zinc	32-34	reticulon 3	Homo sapiens	103-106
27865419-0	2017	GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn2+ distribution.	Zinc	77-81	G protein-coupled receptor 39	Mus musculus	0-5
27865419-2	2017	Increasing evidence suggests that GPR39 is potently stimulated by zinc ions (Zn2+) and is therefore considered a putative Zn2+ receptor.	Zinc	77-81	G protein-coupled receptor 39	Mus musculus	34-39
27865419-3	2017	Given the importance of Zn2+ in the reproductive system, we proposed that GPR39 might have a functional role in the reproductive system.	Zinc	24-28	G protein-coupled receptor 39	Mus musculus	74-79
27166256-4	2016	The ubiquitous mammalian ZIP8 divalent cation transporter (encoded by the SLC39A8 gene) is bicarbonate-dependent, moving endogenous substrates (Zn2+, Mn2+, Fe2+ or Co2+) and nonessential metals such as Cd2+ into the cell.	Zinc	144-148	solute carrier family 39 member 8	Homo sapiens	25-29
27166256-4	2016	The ubiquitous mammalian ZIP8 divalent cation transporter (encoded by the SLC39A8 gene) is bicarbonate-dependent, moving endogenous substrates (Zn2+, Mn2+, Fe2+ or Co2+) and nonessential metals such as Cd2+ into the cell.	Zinc	144-148	solute carrier family 39 member 8	Homo sapiens	74-81
27251638-6	2016	The release of Zn(2+) from MT is associated with a greater increase in p38 MAPK activation following restimulation and decreased p38 MAPK activation in MT knockout Tr1 cells can be rescued by increasing intracellular [Zn(2+)].	Zinc	15-17	mitogen-activated protein kinase 14	Mus musculus	71-74
27251638-6	2016	The release of Zn(2+) from MT is associated with a greater increase in p38 MAPK activation following restimulation and decreased p38 MAPK activation in MT knockout Tr1 cells can be rescued by increasing intracellular [Zn(2+)].	Zinc	15-17	mitogen-activated protein kinase 14	Mus musculus	129-132
27865419-6	2017	Moreover, using ZnSeAMG staining, we found that Zn2+, the putative ligand of GPR39, also found a distribution similar to GPR39 expression, suggesting that their potential interaction mediates fertilization and embryo transportation.	Zinc	48-52	G protein-coupled receptor 39	Mus musculus	77-82
31193510-7	2019	TEM results showed particulate polycrystalline apatite with crystallite size ranging from 68 nm in pure HAp to 41 nm in 20% Zn-doped HAp indicating a decrease in the crystal size with increasing Zn ion in the samples.	Zinc	124-126	reticulon 3	Homo sapiens	133-136
27251638-6	2016	The release of Zn(2+) from MT is associated with a greater increase in p38 MAPK activation following restimulation and decreased p38 MAPK activation in MT knockout Tr1 cells can be rescued by increasing intracellular [Zn(2+)].	Zinc	15-21	mitogen-activated protein kinase 14	Mus musculus	71-74
27251638-6	2016	The release of Zn(2+) from MT is associated with a greater increase in p38 MAPK activation following restimulation and decreased p38 MAPK activation in MT knockout Tr1 cells can be rescued by increasing intracellular [Zn(2+)].	Zinc	15-21	mitogen-activated protein kinase 14	Mus musculus	129-132
31108985-5	2019	In addition, the CuS-CNF/GCE shows a selective identification of HQ and CC over potential interfering metal ions (Zn2+, Na+, K+, NO3-, SO42-, Cl-) and organic compounds (ascorbic acid, glucose), and a satisfactory recovery is also obtained in the spiked water samples.	Zinc	114-118	glycine decarboxylase	Homo sapiens	25-28
27251136-8	2016	S100A8 binds two zinc ions per homodimer, through two symmetrical, all-His tetracoordination sites, revealing a classical His-Zn binding mode for the protein.	Zinc	126-128	S100 calcium binding protein A8	Homo sapiens	0-6
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-37	S100 calcium binding protein A8	Homo sapiens	51-58
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-37	S100 calcium binding protein A8	Homo sapiens	52-58
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-33	S100 calcium binding protein A8	Homo sapiens	51-58
27251136-11	2016	CONCLUSIONS: Our structures of Zn(2+)/Ca(2+)-bound hS100A8 demonstrate that S100A8 is a genuine His-Zn S100 protein.	Zinc	31-33	S100 calcium binding protein A8	Homo sapiens	52-58
27806940-12	2017	Specifically, TPEN promotes Nox2 expression and activation, which are reversed when intracellular Zn2+ levels are restored following Zn2+ supplementation.	Zinc	98-102	cytochrome b-245, beta polypeptide	Mus musculus	28-32
27806940-12	2017	Specifically, TPEN promotes Nox2 expression and activation, which are reversed when intracellular Zn2+ levels are restored following Zn2+ supplementation.	Zinc	133-137	cytochrome b-245, beta polypeptide	Mus musculus	28-32
27806940-14	2017	Together, these findings reveal that Nox2 is a Zn2+-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy.	Zinc	47-51	cytochrome b-245, beta polypeptide	Mus musculus	37-41
27917477-4	2017	SV31 was preferentially monomeric in detergent and revealed specific binding of Zn2+ .	Zinc	80-84	transmembrane protein 163	Homo sapiens	0-4
27917477-5	2017	When co-translationally inserted into defined nanodisc bilayers, SV31 assembled into dimeric complexes, resulting in increased binding of Zn2+ .	Zinc	138-142	transmembrane protein 163	Homo sapiens	65-69
30984950-2	2019	The zinc(ii) complexes of L1 (HCDLPCGVY-NH2), L2 (Ac-HCDLPCGVY-NH2) and L3 (HCDLACGVY-NH2) and the nickel(ii) and zinc(ii) complexes of L4 (HCDLPCG-NH2) were studied by pH-potentiometric and several spectroscopic methods.	Zinc	4-12	immunoglobulin kappa variable 3-15	Homo sapiens	30-48
27917477-6	2017	Putative Zn2+ -binding motifs within SV31 comprise aspartic acid and histidine residues.	Zinc	9-13	transmembrane protein 163	Homo sapiens	37-41
27917477-9	2017	We demonstrate proton-dependent transport of Zn2+ as by accumulation of fluorescent FluoZin-1 inside of SV31-containing proteoliposomes.	Zinc	45-49	transmembrane protein 163	Homo sapiens	104-108
30610192-5	2019	GPR39 encodes a Zn2+-binding metabotropic receptor known to modulate excitatory and inhibitory neurotransmission, the balance of which is altered in AUD.	Zinc	16-20	G-protein coupled receptor 39	Macaca mulatta	0-5
27611765-0	2016	Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.	Zinc	25-29	kallikrein related peptidase 10	Homo sapiens	61-92
27611765-5	2016	Crystal structures of recombinant ligand-free KLK10 and a Zn2+ bound form explain to some extent the mixed trypsin- and chymotrypsin-like substrate specificity.	Zinc	58-62	kallikrein related peptidase 10	Homo sapiens	46-51
27611765-6	2016	Zn2+-inhibition of KLK10 appears to be based on a unique mechanism, which involves direct binding and blocking of the catalytic triad.	Zinc	0-4	kallikrein related peptidase 10	Homo sapiens	19-24
30578643-4	2019	Nab2 Zn fingers 5-7 have a defined spatial arrangement, with fingers 5 and 7 arranged on one side of the cluster and finger 6 on the other side.	Zinc	5-7	NGFI-A binding protein 2	Homo sapiens	0-4
27622309-3	2016	We used the Zn outer shell of the QD to bind HIS6 in JB577 (W G Dap(N-Palmitoyl) VKIKK P9  G2  H6 ) and by a gel-shift assay showed that siRNAs would bind to the positively charged KIKK sequence.	Zinc	12-14	death associated protein	Homo sapiens	64-67
27811086-3	2016	In tobacco, expression of the export protein AtHMA4 modified Zn/Cd root/shoot distribution, but the pattern depended on their concentrations in the medium.	Zinc	61-63	heavy metal atpase 4	Arabidopsis thaliana	45-51
30678993-1	2019	The cellular prion protein (PrPC) is a zinc-binding protein that contributes to the regulation of Zn2+ and other divalent species of the central nervous system.	Zinc	98-102	prion protein	Mus musculus	28-32
27647906-2	2016	Zn2+ is an important physiological inhibitor of Hv1.	Zinc	0-4	hydrogen voltage gated channel 1	Homo sapiens	48-51
27647906-3	2016	Sperm cells are quiescent in the male reproductive system due to Zn2+ inhibition of Hv1 channels, but become active once introduced into the low-Zn2+-concentration environment of the female reproductive tract.	Zinc	65-69	hydrogen voltage gated channel 1	Homo sapiens	84-87
27647906-4	2016	How Zn2+ inhibits Hv1 is not completely understood.	Zinc	4-8	hydrogen voltage gated channel 1	Homo sapiens	18-21
27647906-5	2016	In this study, we use the voltage clamp fluorometry technique to identify the molecular mechanism of Zn2+ inhibition of Hv1.	Zinc	101-105	hydrogen voltage gated channel 1	Homo sapiens	120-123
27647906-6	2016	We find that Zn2+ binds to both the activated closed and resting closed states of the Hv1 channel, thereby inhibiting both voltage sensor motion and gate opening.	Zinc	13-17	hydrogen voltage gated channel 1	Homo sapiens	86-89
27647906-7	2016	Mutations of some Hv1 residues affect only Zn2+ inhibition of the voltage sensor motion, whereas mutations of other residues also affect Zn2+ inhibition of gate opening.	Zinc	43-47	hydrogen voltage gated channel 1	Homo sapiens	18-21
27647906-8	2016	These effects are similar in monomeric and dimeric Hv1 channels, suggesting that the Zn2+-binding sites are localized within each subunit of the dimeric Hv1.	Zinc	85-89	hydrogen voltage gated channel 1	Homo sapiens	51-54
30678993-2	2019	Zn2+ coordinates to the flexible, N-terminal repeat region of PrPC and drives a tertiary contact between this repeat region and a well-defined cleft of the C-terminal domain.	Zinc	0-4	prion protein	Mus musculus	62-66
27647906-8	2016	These effects are similar in monomeric and dimeric Hv1 channels, suggesting that the Zn2+-binding sites are localized within each subunit of the dimeric Hv1.	Zinc	85-89	hydrogen voltage gated channel 1	Homo sapiens	153-156
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	16-20	hydrogen voltage gated channel 1	Homo sapiens	54-57
30529889-5	2019	In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd.	Zinc	77-79	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	38-41
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	16-20	hydrogen voltage gated channel 1	Homo sapiens	171-174
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	16-20	hydrogen voltage gated channel 1	Homo sapiens	171-174
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	54-57
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	171-174
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	171-174
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	54-57
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	171-174
27647906-9	2016	We propose that Zn2+ binding has two major effects on Hv1: (i) at low concentrations, Zn2+ binds to one site and prevents the opening conformational change of the pore of Hv1, thereby inhibiting proton conduction; and (ii) at high concentrations, Zn2+, in addition, binds to a second site and inhibits the outward movement of the voltage sensor of Hv1.	Zinc	86-90	hydrogen voltage gated channel 1	Homo sapiens	171-174
30592419-0	2019	Strong Phonon-Phonon Interactions Securing Extraordinary Thermoelectric Ge1- xSb xTe with Zn-Alloying-Induced Band Alignment.	Zinc	90-92	enhancer of mRNA decapping 4	Homo sapiens	72-75
27647906-10	2016	Elucidating the molecular mechanism of how Zn2+ inhibits Hv1 will further our understanding of Hv1 function and might provide valuable information for future drug development for Hv1 channels.	Zinc	43-47	hydrogen voltage gated channel 1	Homo sapiens	57-60
27647906-10	2016	Elucidating the molecular mechanism of how Zn2+ inhibits Hv1 will further our understanding of Hv1 function and might provide valuable information for future drug development for Hv1 channels.	Zinc	43-47	hydrogen voltage gated channel 1	Homo sapiens	95-98
30592419-4	2019	In addition, an extra 2-6% Zn alloying decreases the energy offset between valence band edges at L and Sigma points in Ge1- xSb xTe that is found to be induced by the Ge 4s2 lone pairs.	Zinc	27-29	enhancer of mRNA decapping 4	Homo sapiens	119-122
27647906-10	2016	Elucidating the molecular mechanism of how Zn2+ inhibits Hv1 will further our understanding of Hv1 function and might provide valuable information for future drug development for Hv1 channels.	Zinc	43-47	hydrogen voltage gated channel 1	Homo sapiens	95-98
30680275-4	2019	The main diffraction patterns of stannous fluoride (SnF2) were also identified and a reduction in intensity with increasing Zn percentage was evidenced.	Zinc	124-126	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	52-56
27385273-5	2016	The synergistic effects of Zn(2+) and DA on PC12 cell death can be accounted for by an activation of the Gadd45b-induced cell death pathway and an inhibition of p38/JNK survival pathway.	Zinc	27-29	mitogen activated protein kinase 14	Rattus norvegicus	161-164
27385273-6	2016	Furthermore, the in vivo results show that the levels of Gadd45b protein expression and phosphorylation of p38 were increased in the substantia nigra by the infusion of Zn(2+) /DA in the mouse brain and the level of Gadd45b mRNA is significantly higher in the substantia nigra of male PD patients than normal controls.	Zinc	169-175	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	57-64
27385273-6	2016	Furthermore, the in vivo results show that the levels of Gadd45b protein expression and phosphorylation of p38 were increased in the substantia nigra by the infusion of Zn(2+) /DA in the mouse brain and the level of Gadd45b mRNA is significantly higher in the substantia nigra of male PD patients than normal controls.	Zinc	169-175	mitogen-activated protein kinase 14	Mus musculus	107-110
31860849-14	2019	CONCLUSION: Conclusions: Taking into account the fact that MMPs belong to Zn- and Ca-dependent proteolytic enzymes, it can be assumed that microelementosis and changes in the level of MMP-2 found in women are interrelated, they are complex and contribute to the creation of favorable conditions for the risk of development of PIs and other complications of the fetus.	Zinc	74-76	matrix metallopeptidase 2	Homo sapiens	59-63
27519859-1	2016	BACKGROUND: To increase the Zn level in shoots, AtHMA4 was ectopically expressed in tomato under the constitutive CaMV 35S promoter.	Zinc	28-30	heavy metal atpase 4	Arabidopsis thaliana	48-54
27519859-3	2016	Modification of Zn root/shoot distribution in tomato expressing 35S::AtHMA4 depended on the concentration of Zn in the medium, thus indicating involvement of unknown endogenous metal-homeostasis mechanisms.	Zinc	16-18	heavy metal atpase 4	Arabidopsis thaliana	69-75
27519859-3	2016	Modification of Zn root/shoot distribution in tomato expressing 35S::AtHMA4 depended on the concentration of Zn in the medium, thus indicating involvement of unknown endogenous metal-homeostasis mechanisms.	Zinc	109-111	heavy metal atpase 4	Arabidopsis thaliana	69-75
31860849-14	2019	CONCLUSION: Conclusions: Taking into account the fact that MMPs belong to Zn- and Ca-dependent proteolytic enzymes, it can be assumed that microelementosis and changes in the level of MMP-2 found in women are interrelated, they are complex and contribute to the creation of favorable conditions for the risk of development of PIs and other complications of the fetus.	Zinc	74-76	matrix metallopeptidase 2	Homo sapiens	184-189
30618610-3	2018	Here, we demonstrate that NCS-1 also has Zn2+-binding sites, which affect its structural and functional properties upon filling.	Zinc	41-45	neuronal calcium sensor 1	Homo sapiens	26-31
27519859-5	2016	RESULTS: Zn-supply-dependent modification of Zn root/shoot distribution in AtHMA4-tomato (increase at 5 muM Zn, no change at 0.5 muM Zn) involved tissue-specific, distinct from that in the wild type, expression of tomato endogenous genes.	Zinc	9-11	heavy metal atpase 4	Arabidopsis thaliana	75-81
27519859-5	2016	RESULTS: Zn-supply-dependent modification of Zn root/shoot distribution in AtHMA4-tomato (increase at 5 muM Zn, no change at 0.5 muM Zn) involved tissue-specific, distinct from that in the wild type, expression of tomato endogenous genes.	Zinc	45-47	heavy metal atpase 4	Arabidopsis thaliana	75-81
27519859-5	2016	RESULTS: Zn-supply-dependent modification of Zn root/shoot distribution in AtHMA4-tomato (increase at 5 muM Zn, no change at 0.5 muM Zn) involved tissue-specific, distinct from that in the wild type, expression of tomato endogenous genes.	Zinc	45-47	heavy metal atpase 4	Arabidopsis thaliana	75-81
27519859-5	2016	RESULTS: Zn-supply-dependent modification of Zn root/shoot distribution in AtHMA4-tomato (increase at 5 muM Zn, no change at 0.5 muM Zn) involved tissue-specific, distinct from that in the wild type, expression of tomato endogenous genes.	Zinc	45-47	heavy metal atpase 4	Arabidopsis thaliana	75-81
27519859-10	2016	CONCLUSIONS: In transgenic tomato plants, the export activity of ectopically expressed AtHMA4 changes the cellular Zn status, which induces coordinated tissue-specific responses of endogenous ethylene-related genes and metal transporters.	Zinc	115-117	heavy metal atpase 4	Arabidopsis thaliana	87-93
27095402-4	2016	Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system.	Zinc	91-93	ZIP8	Arabidopsis thaliana	32-36
27248371-5	2016	Lower concentrations (&lt;80 muM) of Zn(2+) had no adverse effects on cell viability but promoted cell adhesion, cell spreading, cell proliferation, cell migration, and enhanced the expression of F-actin and vinculin.	Zinc	37-39	vinculin	Homo sapiens	208-216
30618610-4	2018	Fluorescence and circular dichroism experiments reveal the impact of Zn2+ binding on NCS-1 secondary and tertiary structure.	Zinc	69-73	neuronal calcium sensor 1	Homo sapiens	85-90
30618610-5	2018	According to atomic absorption spectroscopy and isothermal titration calorimetry studies, apo-NCS-1 has two high-affinity (4 x 106 M-1) and one low-affinity (2 x 105 M-1) Zn2+-binding sites, whereas Mg2+-loaded and Ca2+-loaded forms (which dominate under physiological conditions) bind two zinc ions with submicromolar affinity.	Zinc	171-175	neuronal calcium sensor 1	Homo sapiens	94-99
29997800-1	2016	A highly luminescent and water-stable homochiral Zn-MOF, i.e., Zn-PLA, has been developed based on a pyrene-tetralactic acid, which inherently features concave shapes for guest inclusion, to explore sensing of amino acids by fluorescence quenching; the solid-state fluorescence quantum yield of the MOF was found to be 46%.	Zinc	49-51	lysine acetyltransferase 8	Homo sapiens	52-55
30618610-6	2018	Metal competition analysis and circular dichroism studies suggest that Zn2+-binding sites of apo- and Mg2+-loaded NCS-1 overlap with functional EF-hands of the protein.	Zinc	71-75	neuronal calcium sensor 1	Homo sapiens	114-119
29997800-1	2016	A highly luminescent and water-stable homochiral Zn-MOF, i.e., Zn-PLA, has been developed based on a pyrene-tetralactic acid, which inherently features concave shapes for guest inclusion, to explore sensing of amino acids by fluorescence quenching; the solid-state fluorescence quantum yield of the MOF was found to be 46%.	Zinc	49-51	lysine acetyltransferase 8	Homo sapiens	299-302
30618610-8	2018	Meanwhile, one of the EF-hands of Zn2+-saturated NCS-1 exhibits a 14-fold higher calcium affinity, which increases the overall calcium sensitivity of the protein.	Zinc	34-38	neuronal calcium sensor 1	Homo sapiens	49-54
30618610-9	2018	Based on QM/MM molecular dynamics simulations, Zn2+ binding to Ca2+-loaded NCS-1 could occur at EF-hands 2 and 4.	Zinc	47-51	neuronal calcium sensor 1	Homo sapiens	75-80
26936488-7	2016	The resultant peptide [CP-1(CAHH)] was evaluated for its ability to coordinate Zn(II) and Co(II) ions, adopt secondary structure, and promote hydrolysis.	Zinc	79-85	ring finger protein 216	Homo sapiens	28-32
27154022-2	2016	Zn(2+) binding to OT is known to increase the affinity of OT for its receptor [Pearlmutter, A. F., Soloff, M. S.: Characterization of the metal ion requirement for oxytocin-receptor interaction in rat mammary gland membranes.	Zinc	0-2	oxytocin receptor	Rattus norvegicus	164-181
26936488-8	2016	CP-1(CAHH) was found to coordinate Co(II) and Zn(II) and a pentacoordinate geometry for Co(II)-CP-1(CAHH) was implicated from UV-vis data.	Zinc	46-52	ring finger protein 216	Homo sapiens	5-9
30397150-3	2018	We found that in middle-aged rats a Zn-deficient diet reduces prostatic Zn levels (P = 0.025), increases cellular proliferation, and induces an inflammatory phenotype with COX-2 overexpression.	Zinc	36-38	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	172-177
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	bone morphogenetic protein 2	Homo sapiens	140-168
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	bone morphogenetic protein 2	Homo sapiens	170-174
26872532-3	2016	We demonstrate that not only zinc (Zn(2+)) but also copper (Cu(2+)) and protons (H(+)) are agonists of ZAC, displaying potencies and efficacies in the rank orders of H(+)&gt;Cu(2+)&gt;Zn(2+) and H(+)&gt;Zn(2+)&gt;Cu(2+), respectively.	Zinc	35-37	zinc activated ion channel	Homo sapiens	103-106
30459425-3	2018	Here, we report that introduction of histidine at this position, D918H, makes TRPA1 channels sensitive to block by nanomolar concentration of Zn2+ and can be used to functionally tag subunits in concatemers.	Zinc	142-146	transient receptor potential cation channel subfamily A member 1	Homo sapiens	78-83
26872532-3	2016	We demonstrate that not only zinc (Zn(2+)) but also copper (Cu(2+)) and protons (H(+)) are agonists of ZAC, displaying potencies and efficacies in the rank orders of H(+)&gt;Cu(2+)&gt;Zn(2+) and H(+)&gt;Zn(2+)&gt;Cu(2+), respectively.	Zinc	184-186	zinc activated ion channel	Homo sapiens	103-106
26872532-3	2016	We demonstrate that not only zinc (Zn(2+)) but also copper (Cu(2+)) and protons (H(+)) are agonists of ZAC, displaying potencies and efficacies in the rank orders of H(+)&gt;Cu(2+)&gt;Zn(2+) and H(+)&gt;Zn(2+)&gt;Cu(2+), respectively.	Zinc	184-186	zinc activated ion channel	Homo sapiens	103-106
26872532-6	2016	The permeabilities of ZAC for Na(+) and K(+) relative to Cs(+) are indistinguishable, whereas replacing all of extracellular Na(+) and K(+) with the divalent cations Ca(2+) or Mg(2+) results in complete elimination of Zn(2+)-activated currents at both negative and positive holding potentials.	Zinc	218-224	zinc activated ion channel	Homo sapiens	22-25
26872532-9	2016	ZAC could be an important mediator of some of the wide range of physiological functions regulated by or involving Zn(2+), Cu(2+) and H(+).	Zinc	114-116	zinc activated ion channel	Homo sapiens	0-3
30266832-7	2018	The same sites were occupied by zinc ions in the structure of Rv3488-Zn, with two additional zinc ions complexed in one monomer.	Zinc	69-71	hypothetical protein	Mycobacterium tuberculosis H37Rv	62-68
26925211-9	2016	The GluC cleavage site is in close proximity to the His3Asp metal-binding site, which coordinates Zn(II) with high affinity, and Zn(II) chelation protects the S100A8 subunit from GluC cleavage.	Zinc	98-100	S100 calcium binding protein A8	Homo sapiens	159-165
26925211-9	2016	The GluC cleavage site is in close proximity to the His3Asp metal-binding site, which coordinates Zn(II) with high affinity, and Zn(II) chelation protects the S100A8 subunit from GluC cleavage.	Zinc	129-131	S100 calcium binding protein A8	Homo sapiens	159-165
30236453-6	2018	Zn accumulation in mitochondria was induced by hCG stimulation.	Zinc	0-2	chorionic gonadotropin subunit beta 5	Homo sapiens	47-50
26776086-1	2016	A new 3D porous anionic MOF (AMOF-1) based on Zn(II) and a flexible tetracarboxylate linker has been synthesized.	Zinc	46-52	lysine acetyltransferase 8	Homo sapiens	24-27
30417860-6	2018	To obtain the requisite Zn-polarity, careful surface treatment of GaN templates and control over the VI/II ratio during the growth of low temperature ZnO nucleation layer are utilized.	Zinc	24-26	cytochrome c oxidase subunit 8A	Homo sapiens	101-106
26715398-9	2016	The negative surface charge of NPs (COOH(-)) binds to the Zn(2+) of the MMP active center by chelation, leading to MMP inhibition.	Zinc	58-60	matrix metallopeptidase 13	Mus musculus	72-75
26715398-9	2016	The negative surface charge of NPs (COOH(-)) binds to the Zn(2+) of the MMP active center by chelation, leading to MMP inhibition.	Zinc	58-60	matrix metallopeptidase 13	Mus musculus	115-118
26574547-0	2016	Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.	Zinc	0-4	neurotrophic receptor tyrosine kinase 1	Homo sapiens	33-36
26574547-0	2016	Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.	Zinc	148-152	neurotrophic receptor tyrosine kinase 1	Homo sapiens	33-36
26574547-4	2016	Zn(2+)-mediated phosphorylation of STEP61 at multiple sites (hyperphosphorylation) was induced by the up-regulation of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activation of cAMP-dependent PKA (protein kinase A).	Zinc	0-2	protein tyrosine phosphatase non-receptor type 5	Homo sapiens	35-41
26574547-4	2016	Zn(2+)-mediated phosphorylation of STEP61 at multiple sites (hyperphosphorylation) was induced by the up-regulation of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activation of cAMP-dependent PKA (protein kinase A).	Zinc	0-2	neurotrophic receptor tyrosine kinase 1	Homo sapiens	160-187
26574547-4	2016	Zn(2+)-mediated phosphorylation of STEP61 at multiple sites (hyperphosphorylation) was induced by the up-regulation of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activation of cAMP-dependent PKA (protein kinase A).	Zinc	0-2	neurotrophic receptor tyrosine kinase 1	Homo sapiens	189-192
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	97-103	neurotrophic receptor tyrosine kinase 1	Homo sapiens	54-57
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	76-78	solute carrier family 39 member 14	Homo sapiens	219-224
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	128-130	solute carrier family 39 member 14	Homo sapiens	219-224
25594566-4	2016	In this system, a commercial polyclonal antibody raised against human metal-responsive transcription factor-1 protein (MTF-1 protein) could modify the electrophoretic migration patterns (i.e. cause specific decreases in agarose gel electrophoretic mobility) of the plasmid in the presence or absence of heavy metals other than zinc (Zn).	Zinc	333-335	metal regulatory transcription factor 1	Homo sapiens	119-124
25594566-9	2016	The Zn effect was reversed/modified by adding MTF-1 protein.	Zinc	4-6	metal regulatory transcription factor 1	Homo sapiens	46-51
29774825-3	2018	Because dietary zinc (Zn) improved recovery in nonblast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- (LoZn) and adequate-Zn (AdZn) diets on MMP expression and behavioral responses, subsequent to exposure to a single blast.	Zinc	86-88	matrix metallopeptidase 2	Rattus norvegicus	77-81
26623569-4	2016	The results showed that both CK2 inhibitors, 4,5,6,7-tetrabromobenzotriazole (TBB) and quinalizarin, markedly reduced the toxicity of Zn(ii), Al(iii), Co(ii), Cr(vi) and As(iii).	Zinc	134-136	casein kinase 2, alpha prime polypeptide	Mus musculus	29-32
29774825-9	2018	Taken together, our results support a relationship between marginally Zn-deficient status and a compromised regenerative response post-injury in muscle, likely through the MMP pathway.	Zinc	70-72	matrix metallopeptidase 2	Rattus norvegicus	172-175
29774825-10	2018	However, in neuronal tissue, changes in MMP/TIMP levels after blast indicate a variable response to marginally Zn-deficient diets that may help explain compromised repair mechanism(s) previously associated with the systemic hypozincemia that develops in patients with TBI.	Zinc	111-113	matrix metallopeptidase 2	Rattus norvegicus	40-43
29668173-10	2016	There was a significant positive correlation between elastase1 and Zn/Cu ratio (r = 0.396, p &lt; 0.001).	Zinc	67-69	chymotrypsin like elastase 1	Homo sapiens	53-62
26529669-10	2015	CONCLUSIONS: These results suggest that genetic variation in the MT gene region and MTF1 influences urinary Cd, Cu, and Zn excretion.	Zinc	120-122	metal regulatory transcription factor 1	Homo sapiens	84-88
30204443-1	2018	The voltage-gated proton channel (Hv1/VSOP) is inhibited by Zn2+, of which the binding site is located in the extracellular region.	Zinc	60-64	hydrogen voltage gated channel 1	Homo sapiens	34-37
30204443-1	2018	The voltage-gated proton channel (Hv1/VSOP) is inhibited by Zn2+, of which the binding site is located in the extracellular region.	Zinc	60-64	hydrogen voltage gated channel 1	Homo sapiens	38-42
30204443-3	2018	The Zn2+-induced difference ATR-FTIR spectra of Hv1 showed IR features that can be assigned to the histidine C5-N1 and carboxylate-COO- stretches as well as amide I changes likely in alpha-helical peptide bonds.	Zinc	4-8	hydrogen voltage gated channel 1	Homo sapiens	48-51
26575792-4	2015	The good photocatalytic reduction was related to the narrower bandgap of (AgIn)(x)Zn(2(1-x))S2 solid solution because of the hybridized orbitals of Ag, In, Zn, and S and low recombination rate of photogenerated electron and hole pairs due to the effectiveness of p-type Ag2S and n-type (AgIn)(x)Zn(2(1-x))S2 nanoheterojunctions.	Zinc	82-84	angiotensin II receptor type 1	Homo sapiens	270-274
31950612-5	2018	In particular, the Co3 O4 /ZnO hybrid nanostructured electrode (60 s) exhibits the lowest onset potential of 1.5 V (vs. reversible hydrogen electrode, RHE).	Zinc	27-30	factor interacting with PAPOLA and CPSF1	Homo sapiens	151-154
26409456-3	2015	The purpose of this study was to determine the effects of Zn concentration in cell culture on the expression of miR-548n, SMAD4 and SMAD5 in hepatocyte (HepG2) and lung epithelium (HEp-2) cell lines.	Zinc	58-60	SMAD family member 4	Homo sapiens	122-127
26409456-8	2015	HEp-2 miR-548n expression increased 23-fold, while SMAD4 expression decreased twofold, in 50 muM Zn-treated cells.	Zinc	97-99	SMAD family member 4	Homo sapiens	51-56
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	SMAD family member 4	Homo sapiens	0-5
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	SMAD family member 4	Homo sapiens	173-178
28919489-5	2018	TRPA1 was shown to be activated by Zn2+ which was linked to pain and inflammation.	Zinc	35-39	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
26298079-1	2015	A novel luminescent lanthanide metal organic framework (Ln-MOF) is synthesized by in situ encapsulating Eu(3+) ions to partial replace the transition-metal clusters in the channels of CPM-17-Zn nanocrystals.	Zinc	191-193	lysine acetyltransferase 8	Homo sapiens	59-62
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	190-192	CREB regulated transcription coactivator 1	Mus musculus	51-57
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	219-221	CREB regulated transcription coactivator 1	Mus musculus	51-57
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	219-221	CREB regulated transcription coactivator 1	Mus musculus	51-57
27063502-2	2016	A3F is one of the four APOBEC members with two Zn-coordinated homologous cytosine deaminase (CD) domains, with the others being A3G, A3D, and A3B.	Zinc	47-49	apolipoprotein B mRNA editing enzyme catalytic subunit 3F	Homo sapiens	0-3
27235627-7	2016	Next, we found that Zn(2+) supported robust polalpha reactions when the concentration of nucleotides was above the concentration of ions; however, there was only one nucleotide incorporation by the Klenow fragment of DNA pol I. Zn(2+) drastically inhibited polalpha, but had no effect on Klenow, when Mg(2+) was also present.	Zinc	20-22	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	44-52
27235627-7	2016	Next, we found that Zn(2+) supported robust polalpha reactions when the concentration of nucleotides was above the concentration of ions; however, there was only one nucleotide incorporation by the Klenow fragment of DNA pol I. Zn(2+) drastically inhibited polalpha, but had no effect on Klenow, when Mg(2+) was also present.	Zinc	20-22	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	257-265
29458585-2	2018	Rh6G-Cin displayed high selectivity towards Zn2+ from various metal ions, including Ca2+, Ag+, Cd2+, Co2+, Cu2+, Al3+, Zn2+, Cr3+, Ba2+, Fe2+, Fe3+, Gd3+, Hg2+, Mg2+, Mn2+, Nd3+, Pb2+, Sr2+ and Ni2+, and the resultant complex is [Rh6G-Cin-Zn2+].	Zinc	119-123	pyridoxal phosphatase	Homo sapiens	5-8
26315400-2	2015	Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis.	Zinc	41-43	thyrotropin releasing hormone	Rattus norvegicus	137-140
26315400-2	2015	Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis.	Zinc	41-43	thyrotropin releasing hormone	Rattus norvegicus	227-230
30050082-1	2018	A synthetic derivative, GnRH [6-D-Phe], stable against enzymatic degradation, self-assembles and forms nanostructures and fibrils upon a pH shift in the presence of different concentrations of Zn2+ in vitro.	Zinc	193-197	gonadotropin releasing hormone 1	Homo sapiens	24-28
27063150-7	2016	Thus, the enzymatic activity of APE1 is increased in the order Zn(2+) &lt; Ni(2+) &lt; Mn(2+) &lt; Mg(2+).	Zinc	63-65	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	32-36
30050082-2	2018	Attenuated Total Reflection Fourier Transform Infrared spectroscopy (ATR-FTIR) revealed the existence of higher order assembly of Zn2+: GnRH [6-D-Phe].	Zinc	130-134	gonadotropin releasing hormone 1	Homo sapiens	136-140
30050082-3	2018	Nuclear Magnetic Resonance spectroscopy (NMR) indicated a weak interaction between Zn2+ and GnRH [6-D-Phe].	Zinc	83-87	gonadotropin releasing hormone 1	Homo sapiens	92-96
30050082-5	2018	Molecular Dynamic (MD) simulation of the 10:1 Zn2+: GnRH [6-D-Phe] explored the interaction and dimerization processes.	Zinc	46-50	gonadotropin releasing hormone 1	Homo sapiens	52-56
30050082-7	2018	The lyophilized Zn2+: GnRH [6-D-Phe] assembly was tested as a platform for the sustained delivery of GnRH [6-D-Phe] and incorporated into two different oil vehicle matrices.	Zinc	16-20	gonadotropin releasing hormone 1	Homo sapiens	101-105
29019078-0	2018	Chitosan-Zn Chelate Downregulates TLR4-NF-kappaB Signal Pathway of Inflammatory Response and Cell Death-Associated Proteins Compared to Inorganic Zinc.	Zinc	9-11	toll like receptor 4	Sus scrofa	34-38
29677391-4	2018	Knockout of FBP results in an enhanced expression of NAS genes and a higher nicotianamine content, and the fbp mutant exhibits tolerance to excessive Zn.	Zinc	150-152	Inositol monophosphatase family protein	Arabidopsis thaliana	12-15
29677391-4	2018	Knockout of FBP results in an enhanced expression of NAS genes and a higher nicotianamine content, and the fbp mutant exhibits tolerance to excessive Zn.	Zinc	150-152	Inositol monophosphatase family protein	Arabidopsis thaliana	107-110
29677391-5	2018	Physiological analyses reveal that the mutant fbp retains a larger amount of Zn in roots and transfers a greater proportion of Fe to shoots than that in wild type under Zn-excessive stress.	Zinc	77-79	Inositol monophosphatase family protein	Arabidopsis thaliana	46-49
29677391-5	2018	Physiological analyses reveal that the mutant fbp retains a larger amount of Zn in roots and transfers a greater proportion of Fe to shoots than that in wild type under Zn-excessive stress.	Zinc	169-171	Inositol monophosphatase family protein	Arabidopsis thaliana	46-49
29845997-0	2018	A robust Zn(ii)/Na(i)-MOF decorated with [(OAc)2(H2O)2]n2n- anions for the luminescence sensing of copper ions based on the inner filter effect.	Zinc	9-15	lysine acetyltransferase 8	Homo sapiens	22-25
29845997-1	2018	Based on the inner filter effect, a luminescent Zn(ii)/Na(i) metal-organic framework (MOF) {[Zn2Na(L)(HL)2(H2O)2][OAc] 2H2O}n (1, H2L = 5-methyl-1,3-benzenedicarboxylic acid) with excellent stability was constructed for the fluorescence detection of Cu2+ ions.	Zinc	48-50	lysine acetyltransferase 8	Homo sapiens	61-90
29743301-8	2018	This is consistent with HtHV1 possessing three of the four amino acids that coordinate Zn2+ in mammalian HV1.	Zinc	87-91	hydrogen voltage gated channel 1	Homo sapiens	26-29
28842860-19	2018	OPG and OPG/RANKL ratios were significantly higher in the OVX-Gen and OVX-Zn groups than that in the OVX group (P &lt; 0.05).	Zinc	74-76	TNF superfamily member 11	Rattus norvegicus	12-17
26939666-0	2016	Zn(2+) -induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels.	Zinc	0-6	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	122-127
26939666-1	2016	KEY POINTS: Increases in intracellular Zn(2+) concentrations are an early, necessary signal for the modulation of Kv2.1 K(+) channel localization and physiological function.	Zinc	39-45	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	114-119
26939666-2	2016	Intracellular Zn(2+) -mediated Kv2.1 channel modulation is dependent on calcineurin, a Ca(2+) -activated phosphatase.	Zinc	14-20	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	31-36
26939666-3	2016	We show that intracellular Zn(2+) induces a significant increase in ryanodine receptor-dependent cytosolic Ca(2+) transients, which leads to a calcineurin-dependent redistribution of Kv2.1 channels from pre-existing membrane clusters to diffuse localization.	Zinc	27-33	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	183-188
26939666-4	2016	As such, the link between Zn(2+) and Ca(2+) signalling in this Kv2.1 modulatory pathway is established.	Zinc	26-28	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	63-68
26939666-7	2016	ABSTRACT: Sublethal injurious stimuli in neurons induce transient increases in free intracellular Zn(2+) that are associated with regulating adaptive responses to subsequent lethal injury, including alterations in the function and localization of the delayed-rectifier potassium channel, Kv2.1.	Zinc	98-100	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	288-293
26939666-8	2016	However, the link between intracellular Zn(2+) signalling and the observed changes in Kv2.1 remain undefined.	Zinc	40-46	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	86-91
26939666-9	2016	In the present study, utilizing exogenous Zn(2+) treatment, along with a selective Zn(2+) ionophore, we show that transient elevations in intracellular Zn(2+) concentrations are sufficient to induce calcineurin-dependent Kv2.1 channel dispersal in rat cortical neurons in vitro, which is accompanied by a relatively small but significant hyperpolarizing shift in the voltage-gated activation kinetics of the channel.	Zinc	42-48	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	221-226
26939666-10	2016	Critically, using a molecularly encoded calcium sensor, we found that the calcineurin-dependent changes in Kv2.1 probably occur as a result of Zn(2+) -induced cytosolic Ca(2+) release via activation of neuronal ryanodine receptors.	Zinc	143-149	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	107-112
27086774-0	2016	Coordination of Zn(2+) and Cu(2+) to the membrane disrupting fragment of amylin.	Zinc	16-18	islet amyloid polypeptide	Homo sapiens	73-79
27086774-4	2016	In this work, the coordination chemistry of Zn(2+) and Cu(2+) with the membrane-disrupting part of amylin (amylin1-19) is discussed.	Zinc	44-46	islet amyloid polypeptide	Homo sapiens	99-105
30001042-7	2016	The results show that the Pb(II)-MICA displayed strong affinity for Pb(II) in the solution and exhibited selectivity for Pb(II) ion in the presence of Cu2+,Cd2+,Ni2+ and Zn2+.	Zinc	170-174	MHC class I polypeptide-related sequence A	Homo sapiens	33-37
28773454-5	2016	The results showed that the optimized product of AgInS2-Ag2S-ZnS nanoparticles synthesized with the precursor ratio of Ag:Zn = 1:1 exhibited the highest H2 evolution rate of 5.4 mmol g-1 h-1.	Zinc	61-63	angiotensin II receptor type 1	Homo sapiens	56-60
26794023-3	2016	However, sulfonamide compound binding to CA IX is linked to several reactions, the deprotonation of the sulfonamide amino group and the protonation of the CA active site Zn(II)-bound hydroxide.	Zinc	170-176	carbonic anhydrase 9	Homo sapiens	41-46
26936488-10	2016	The Zn(II)-bound CP-1(CAHH) was shown to adopt partial secondary structure by 1-D (1)H NMR spectroscopy.	Zinc	4-10	ring finger protein 216	Homo sapiens	22-26
26936488-11	2016	Both Zn(II)-CP-1(CAHH) and Co(II)-CP-1(CAHH) show good hydrolytic activity toward the test substrate 4-nitrophenyl acetate, exhibiting faster rates than most active synthetic Zn(II) complexes.	Zinc	5-11	ring finger protein 216	Homo sapiens	17-21
26936488-11	2016	Both Zn(II)-CP-1(CAHH) and Co(II)-CP-1(CAHH) show good hydrolytic activity toward the test substrate 4-nitrophenyl acetate, exhibiting faster rates than most active synthetic Zn(II) complexes.	Zinc	5-11	ring finger protein 216	Homo sapiens	39-43
27065282-4	2016	The INR and AAC diets provided the same daily amount of Cu, Co, Mn, and Zn.	Zinc	72-74	glycine N-acyltransferase	Bos taurus	12-15
26498180-4	2015	Here we provide evidence that the metal-regulatory transcription factor 1 (MTF1) mediates the increase of CaV3.2 mRNA and intrinsic excitability consequent to a rise in intracellular Zn(2+) that is associated with SE.	Zinc	183-185	metal regulatory transcription factor 1	Homo sapiens	34-73
26498180-4	2015	Here we provide evidence that the metal-regulatory transcription factor 1 (MTF1) mediates the increase of CaV3.2 mRNA and intrinsic excitability consequent to a rise in intracellular Zn(2+) that is associated with SE.	Zinc	183-185	metal regulatory transcription factor 1	Homo sapiens	75-79
26498180-4	2015	Here we provide evidence that the metal-regulatory transcription factor 1 (MTF1) mediates the increase of CaV3.2 mRNA and intrinsic excitability consequent to a rise in intracellular Zn(2+) that is associated with SE.	Zinc	183-185	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	106-112
29928486-2	2018	Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the active site of CA IX inducing novel conformational changes as determined by X-ray crystallography.	Zinc	153-159	carbonic anhydrase 9	Homo sapiens	18-23
25957834-5	2015	As designed, DP-3 exhibits excellent cell permeation and low biotoxicity and displays high selectivity and sensitivity, with Zn(2+) and Cu(2+) detection limits of 82 nM and 78 nM, respectively.	Zinc	125-127	APC regulator of WNT signaling pathway	Homo sapiens	13-17
27065282-8	2016	Liver Co, Cu, and Zn concentrations on d 75 were greater ( &lt;= 0.05) for INR and AAC cows compared with CON cows, whereas INR cows had reduced ( = 0.04) liver Co but greater ( = 0.03) liver Cu compared with AAC cows.	Zinc	18-20	glycine N-acyltransferase	Bos taurus	83-86
27065282-11	2016	Liver Cu and Zn concentrations at birth were greater ( &lt;= 0.05) in calves from AAC cows compared with cohorts from CON cows.	Zinc	13-15	glycine N-acyltransferase	Bos taurus	82-85
29578563-1	2018	A new Zn(ii) metal-organic framework (MOF) [Me2NH2][Zn2(BDPP)(HTZ)] 4DMF (1) (H4BDPP = 3,5-bis(3,5-dicarboxylphenyl)pyridine, HTZ = 1H-tetrazole) has been constructed under solvothermal conditions by using a mixed-ligand strategy.	Zinc	6-12	lysine acetyltransferase 8	Homo sapiens	13-42
26222306-3	2016	Interestingly, spermatogenic cells mainly express CaV 3.2-encoded T-type Ca(2+) currents (ICaT) which are positively or negatively modulated by Zn(2+) in other tissues.	Zinc	144-146	catenin beta interacting protein 1	Homo sapiens	90-94
26222306-4	2016	To explore whether ICaT could be regulated by Zn(2+) and albumin, its main physiological carrier, we performed whole cell electrophysiological recordings of spermatogenic cell ICaT in the absence or presence of different Zn(2+) concentrations.	Zinc	46-48	catenin beta interacting protein 1	Homo sapiens	19-23
26222306-4	2016	To explore whether ICaT could be regulated by Zn(2+) and albumin, its main physiological carrier, we performed whole cell electrophysiological recordings of spermatogenic cell ICaT in the absence or presence of different Zn(2+) concentrations.	Zinc	46-52	catenin beta interacting protein 1	Homo sapiens	19-23
26222306-11	2016	ICaT modulation by Zn(2+) could be relevant for spontaneous Ca(2+) oscillations during spermatogenesis and in pathophysiological conditions such as diabetes.	Zinc	19-21	catenin beta interacting protein 1	Homo sapiens	0-4
26426582-3	2015	By employing a cell viability assay, we examined the effects of various concentrations of Cu2+, Zn2+, Mn2+, and Co2+ on Zpl (Prnp-/-) and ZW (Prnp+/+) hippocampus-derived mouse neuronal cells.	Zinc	96-100	prion protein	Mus musculus	125-140
29223455-7	2018	Moreover, the AuNPsTyr aggregated by Cr3+ or Pb2+ (a combination of them) show excellent selectivity compared to other metal ions (Cr3+, Pb2+, Fe2+,Cu2+,Zn2+,Cr6+,Ni2+,Co2+,Hg2+,Mn2+,Mg2+,Ca2+,Cd2+).	Zinc	153-157	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	37-40
25913317-3	2015	Results from the sequential extraction revealed that more than 50 % of the Cu and Zn were highly mobile and defined within the extractable fraction (AS1 + FM2 + OS3) in the majority of the sediments, in contrast extractable fractions of Ni and Cd were lower than 50 % in most of the sampling sites.	Zinc	82-84	prostaglandin D2 receptor	Homo sapiens	149-152
25376631-3	2015	Significant interactions between Ci and Zn on FCR, EW, EP, or EM were observed (P &lt; 0.05).	Zinc	40-42	FCR	Gallus gallus	46-49
26121325-0	2015	GLP-1 Receptor Mediated Targeting of a Fluorescent Zn(2+) Sensor to Beta Cell Surface for Imaging Insulin/Zn(2+) Release.	Zinc	51-53	glucagon like peptide 1 receptor	Homo sapiens	0-14
26059373-5	2015	The test showed that Zn intake in women significantly correlated with reduced systolic blood pressure (SBP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gamma-GPT), and homeostasis model assessment-insulin resistance (HOMA-IR).	Zinc	21-23	glutamic--pyruvic transaminase	Homo sapiens	109-133
30090406-2	2016	The Zn transporter ZIP8 (also known as SLC39A8) is an important Zn2+ importer; aberrant Zn2+ influx mediated by ZIP8 can lead to the pathogenesis of osteoarthritis and inflammatory diseases.	Zinc	64-68	solute carrier family 39 member 8	Homo sapiens	19-23
30090406-2	2016	The Zn transporter ZIP8 (also known as SLC39A8) is an important Zn2+ importer; aberrant Zn2+ influx mediated by ZIP8 can lead to the pathogenesis of osteoarthritis and inflammatory diseases.	Zinc	64-68	solute carrier family 39 member 8	Homo sapiens	39-46
30090406-2	2016	The Zn transporter ZIP8 (also known as SLC39A8) is an important Zn2+ importer; aberrant Zn2+ influx mediated by ZIP8 can lead to the pathogenesis of osteoarthritis and inflammatory diseases.	Zinc	64-68	solute carrier family 39 member 8	Homo sapiens	112-116
26739447-1	2016	The Zn(2+)-specific ion channel ZIP7 has been implicated to play an important role in releasing Zn(2+) from the ER.	Zinc	4-6	solute carrier family 39 member 7	Homo sapiens	32-36
26739447-2	2016	External stimulation of breast cancer cells has been proposed to induce phosphorylation of ZIP7 by CK2alpha, resulting in ZIP7-mediated Zn(2+) release from the ER into the cytosol.	Zinc	136-138	solute carrier family 39 member 7	Homo sapiens	91-95
26739447-2	2016	External stimulation of breast cancer cells has been proposed to induce phosphorylation of ZIP7 by CK2alpha, resulting in ZIP7-mediated Zn(2+) release from the ER into the cytosol.	Zinc	136-138	solute carrier family 39 member 7	Homo sapiens	122-126
26658105-6	2016	Mutants carrying E272A abrogated Zn-reversal of apoptosis induced by B-PAC-1 via higher XIAP and smac expressions but not in H108A or C148S mutants.	Zinc	33-35	X-linked inhibitor of apoptosis	Mus musculus	88-92
26658105-7	2016	Co-immunoprecipitation analysis revealed stronger XIAP-caspase-3 interaction suggesting a novel mechanism of impulsive apoptosis resistance by disrupting predicted Zn-ligands in caspase-3.	Zinc	164-166	X-linked inhibitor of apoptosis	Mus musculus	50-54
26623569-8	2016	Taken together, these findings shed light on a new facet of CK2 functionality and provide a basis for further research on the regulation of Zn(ii) and Ca(ii) homeostasis by CK2.	Zinc	140-146	casein kinase 2, alpha prime polypeptide	Mus musculus	60-63
26623569-8	2016	Taken together, these findings shed light on a new facet of CK2 functionality and provide a basis for further research on the regulation of Zn(ii) and Ca(ii) homeostasis by CK2.	Zinc	140-146	casein kinase 2, alpha prime polypeptide	Mus musculus	173-176
26720709-0	2015	Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.	Zinc	6-10	G protein-coupled receptor 39	Mus musculus	21-26
26720709-5	2015	A high throughput screen, followed by a medicinal chemistry program, identified three novel potent Zn2+ modulated GPR39 agonists.	Zinc	99-103	G protein-coupled receptor 39	Mus musculus	114-119
26720709-8	2015	It is concluded that Zn2+ modulated GPR39 agonists do not acutely stimulate insulin release in rodents.	Zinc	21-25	G protein-coupled receptor 39	Mus musculus	36-41
26459298-2	2015	Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions.	Zinc	29-37	lysine acetyltransferase 8	Homo sapiens	72-75
26356416-3	2015	Strain TR1 grew at a broad range of pH (3-7) and temperature (20-50  C) and showed good metal tolerance (Pb(2+), Zn(2+), Cu(2+), Ni(2+)), especially for Ni(2+) and Pb(2+), with maximal tolerated concentrations of 0.09 and 0.03 mM, respectively.	Zinc	113-115	taste 1 receptor member 1	Homo sapiens	7-10
26174742-6	2015	In this study, we examined the effect of Zn(2+) on IL-23 p19 mRNA expression using rat immortalized microglia HAPI cells.	Zinc	41-43	interleukin 23 subunit alpha	Rattus norvegicus	51-60
26174742-7	2015	Exposure to Zn(2+) dose- and time-dependently induced the expression of IL-23 p19 mRNA in HAPI cells.	Zinc	12-14	interleukin 23 subunit alpha	Rattus norvegicus	72-81
26174742-10	2015	Treatment with salubrinal, an eIF2alpha dephosphorylation inhibitor, enhanced Zn(2+)-induced ATF4 accumulation and IL-23 p19 mRNA expression.	Zinc	78-84	interleukin 23 subunit alpha	Rattus norvegicus	115-124
26174742-11	2015	In addition, reporter assay using the IL-23 p19 promoter region revealed that ATF4 directly transactivated IL-23 p19 promoter and that dominant-negative ATF4 suppressed Zn(2+)-induced activation of IL-23 p19 promoter.	Zinc	169-171	interleukin 23 subunit alpha	Rattus norvegicus	38-47
26174742-12	2015	Taken together, these findings suggest that Zn(2+) up-regulates expression of the IL-23 p19 gene via the eIF2alpha/ATF4 axis in HAPI cells.	Zinc	44-50	interleukin 23 subunit alpha	Rattus norvegicus	82-91
25580958-4	2015	In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH).	Zinc	44-46	insulin-like growth factor I	Ovis aries	68-96
25580958-4	2015	In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH).	Zinc	44-46	insulin-like growth factor I	Ovis aries	98-103
25757458-4	2015	With increasing Zn concentrations, mRNA and protein levels of metallothionein (MT) and zinc transporter 1 (ZnT1) were upregulated, whereas zinc transporter 4 (ZIP4) expression was downregulated.	Zinc	16-18	solute carrier family 30 member 4	Sus scrofa	139-157
25757458-4	2015	With increasing Zn concentrations, mRNA and protein levels of metallothionein (MT) and zinc transporter 1 (ZnT1) were upregulated, whereas zinc transporter 4 (ZIP4) expression was downregulated.	Zinc	16-18	solute carrier family 30 member 4	Sus scrofa	159-163
25794607-7	2015	Se and Zn supplementation to LPDF rats reversed the elevation in [Ca(2+)]i, calpain and caspase-3 activities and restored the cognitive deficits and the activities of Ca(2+)-ATPase and Na(+)-K(+)-ATPase.	Zinc	7-9	caspase 3	Rattus norvegicus	88-97
25872526-4	2015	The present study identified that 10 microM of Zn supplementation prevented EMT changes, such as the loss of E-cadherin and the increase in alpha-smooth muscle actin and vimentin expression.	Zinc	47-49	vimentin	Rattus norvegicus	170-178
25131383-8	2015	The ALDC of L. lactis DX was activated by Fe(2+) , Zn(2+) , Mg(2+) , Ba(2+) and Ca(2+) , while Cu(2+) significantly inhibited ALDC activity.	Zinc	51-53	aldC	Lactococcus lactis	4-8
25210955-4	2015	Among them, CsHMA3 was predominantly expressed in roots and up-regulated by Pb, Zn and Cd excess, whereas the CsHMA4 transcript was most abundant in roots and flowers of cucumber plants, and elevated under Pb and Zn excess.	Zinc	80-82	putative inactive cadmium/zinc-transporting ATPase HMA3	Cucumis sativus	12-18
25210955-4	2015	Among them, CsHMA3 was predominantly expressed in roots and up-regulated by Pb, Zn and Cd excess, whereas the CsHMA4 transcript was most abundant in roots and flowers of cucumber plants, and elevated under Pb and Zn excess.	Zinc	213-215	cadmium/zinc-transporting ATPase HMA2-like	Cucumis sativus	110-116
25210955-5	2015	Expression of CsHMA3 in Saccharomyces cerevisiae enhanced yeast tolerance to Cd and Pb, whereas CsHMA4 conferred increased resistance of yeast cells to Cd and Zn.	Zinc	159-161	cadmium/zinc-transporting ATPase HMA2-like	Cucumis sativus	96-102
25817891-7	2015	Allosteric suppression of some of the pore-forming Cavalpha1-subunits (Cav2.3, Cav3.2) by Zn(2+) and Cu(2+) may play a major role for the regulation of excitability by endogenous transition metal ions.	Zinc	90-92	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	79-85
26167168-7	2015	The up-regulation of LeNRAMP3 gene in leaf of Ikram/Maxifort could explain the better nutritional status of interspecific grafting combination (higher Fe, Mn, and Zn).	Zinc	163-165	metal transporter	Solanum lycopersicum	21-29
25564338-7	2015	Both MMP-2 and MMP-9 required divalent ions Ca and Zn for its activity and MMP-9 was more active at higher Ca/Zn ratio.	Zinc	51-53	matrix metallopeptidase 2	Homo sapiens	5-10
25564338-7	2015	Both MMP-2 and MMP-9 required divalent ions Ca and Zn for its activity and MMP-9 was more active at higher Ca/Zn ratio.	Zinc	110-112	matrix metallopeptidase 2	Homo sapiens	5-10
29448650-1	2018	We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work.	Zinc	74-82	proprotein convertase subtilisin/kexin type 4	Homo sapiens	157-160
25854679-2	2015	Here we explored the effect of Zn(2+) on PP2A and their direct interaction in vitro.	Zinc	31-37	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	41-45
25854679-4	2015	PP2A activity assays indicated that a low concentration (10 mumol/L) of Zn(2+) inhibited PP2A directly.	Zinc	72-78	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	0-4
25854679-4	2015	PP2A activity assays indicated that a low concentration (10 mumol/L) of Zn(2+) inhibited PP2A directly.	Zinc	72-78	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	89-93
25854679-6	2015	Taken together, Zn(2+) inhibits PP2A directly through binding to PP2Ac(51-270) in vitro.	Zinc	16-22	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	32-36
28290146-11	2018	CXB significantly attenuated Zn-induced increase in COX-2 expression and restored TH-expression, dopamine content, level of inflammatory cytokines and neurobehavioral indexes towards normalcy.	Zinc	29-31	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	52-57
26024021-2	2015	In this work, enhanced photocurrent is achieved by incorporating another type of hole-transporting QDs, Zn-doped CuInS2 (Zn-CIS) QDs into the PbS QD matrix.	Zinc	104-106	cholinergic receptor muscarinic 3	Homo sapiens	142-145
25603538-1	2015	Peptide-hormone secretion is partially triggered by Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) and gene inactivation of Zn2+-sensitive Cav2.3-type VGCCs is associated with disturbed glucose homeostasis in mice.	Zinc	133-137	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	148-154
25603538-4	2015	Fasting glucose and glucagon level were significantly higher in Cav2.3-deficient compared to wild-type mice, while DEDTC Zn2+-chelation produced a significant and correlated increase of blood glucose and serum glucagon concentration in wild-type but not Cav2.3-deficient mice.	Zinc	121-125	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	254-260
28290146-13	2018	Results of the study thus demonstrate that COX-2 induces microglial activation that provokes the release of inflammatory mediators, which in turn augments oxidative stress and intrinsic apoptosis leading to dopaminergic neurodegeneration in Zn-induced Parkinsonism.	Zinc	241-243	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	43-48
25603538-5	2015	Glucose tolerance tests revealed severe glucose intolerance in Zn2+-depleted Cav2.3-deficient but not vehicle-treated Cav2.3-deficient or Zn2+-depleted wildtype mice.	Zinc	63-67	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	77-83
25603538-6	2015	Collectively, these findings indicate that Cav2.3 channels are critically involved in the Zn2+-mediated suppression of glucagon secretion during hyperglycemia.	Zinc	90-94	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	43-49
29292431-0	2018	Multifunctional luminescent Zn(ii)-based metal-organic framework for high proton-conductivity and detection of Cr3+ ions in the presence of mixed metal ions.	Zinc	28-34	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	111-114
25603538-7	2015	Especially under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.	Zinc	31-35	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	75-81
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	Sp7 transcription factor	Homo sapiens	130-137
25761388-1	2015	A mesoporous Zn-based metal-organic framework (MOF) was prepared from a shape-persistent phenylene ethynylene macrocycle functionalized with three -COOH groups.	Zinc	13-15	lysine acetyltransferase 8	Homo sapiens	22-51
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	Sp7 transcription factor	Homo sapiens	159-166
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	Sp7 transcription factor	Homo sapiens	130-137
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	Sp7 transcription factor	Homo sapiens	159-166
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	Sp7 transcription factor	Homo sapiens	130-137
25405524-3	2015	Differences in the zinc-binding affinities of the zinc fingers of MTF-1 and the alpha- and beta-domains of MT facilitate their regulation of Zn2+ concentration.	Zinc	141-145	metal regulatory transcription factor 1	Homo sapiens	66-71
25405524-4	2015	Alterations in the intracellular concentration of Zn2+ influence the MTF-1 zinc finger number, and MTF-1 containing certain zinc finger numbers regulates the expression of corresponding target genes.	Zinc	50-54	metal regulatory transcription factor 1	Homo sapiens	69-74
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	Sp7 transcription factor	Homo sapiens	159-166
29292464-8	2018	Subsequently, Zn2+ can cause the down-regulation of claudin-1, breakage of occludin and ZO-1 rings, and collapse of basolateral F-actin structures.	Zinc	14-18	occludin	Canis lupus familiaris	75-83
29031053-2	2018	The Zn-CNTs was characterized by SEM, BET and XRD, and the degradation of 4-chloro-3-methyl phenol (CMP) in aqueous solution was investigated using Zn-CNTs/O3 system.	Zinc	4-6	delta/notch like EGF repeat containing	Homo sapiens	38-41
28876332-6	2018	RESULTS: In logistic regression models, Zn treatment was associated with greater odds of ID (odds ratio (OR) 1.8 (95% confidence interval (CI) 1.0-3.3)) and MV treatment was associated with lower odds (OR 0.49 (95% CI 0.3-0.9)).	Zinc	40-42	olfactory receptor family 10 subfamily R member 2	Homo sapiens	93-112
25601756-1	2015	Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface.	Zinc	27-29	RAD50 double strand break repair protein	Homo sapiens	0-5
25601756-1	2015	Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface.	Zinc	27-29	RAD50 double strand break repair protein	Homo sapiens	59-64
25601756-3	2015	Here, we focused on rad50 mutations flanking the Zn(2+)-coordinating hook cysteines.	Zinc	49-55	RAD50 double strand break repair protein	Homo sapiens	20-25
25649462-3	2015	Since Zn(2+) concentration determines insulin oligomer equilibrium, we computationally investigated interactions of IAPP with different insulin oligomers and compared with IAPP homodimer formation.	Zinc	6-12	islet amyloid polypeptide	Homo sapiens	116-120
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	apoptotic peptidase activating factor 1	Rattus norvegicus	120-126
31997833-0	2018	The deposition of thin films of cadmium zinc sulfide Cd1-x Zn x S at 250  C from spin-coated xanthato complexes: a potential route to window layers for photovoltaic cells.	Zinc	59-61	CD1c molecule	Homo sapiens	53-56
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	caspase 3	Rattus norvegicus	139-148
25201908-7	2015	The CPCs with ZnBG showed increased ALP activity, enhanced formation of mineralized nodules, and upregulated mRNA expression of DMP-1, DSPP, Runx2, and osterix in a time- and dose-dependent manner, relative to CPCs without Zn.	Zinc	14-16	dentin sialophosphoprotein	Homo sapiens	135-139
25201908-7	2015	The CPCs with ZnBG showed increased ALP activity, enhanced formation of mineralized nodules, and upregulated mRNA expression of DMP-1, DSPP, Runx2, and osterix in a time- and dose-dependent manner, relative to CPCs without Zn.	Zinc	14-16	Sp7 transcription factor	Homo sapiens	152-159
25227315-6	2015	MFAO effects on Abeta:Zn complex formation were evaluated with Zinquin staining and the ability of the Abeta:Zn complex to be degraded by matrix metalloproteinase-2 (MMP-2).	Zinc	109-111	matrix metallopeptidase 2	Homo sapiens	138-164
31997833-8	2018	This work is the first study to demonstrate Cd1-x Zn x S thin films by a spin coating/melt method from xanthato precursors.	Zinc	50-52	CD1c molecule	Homo sapiens	44-47
25227315-11	2015	MFAOs also removed zinc from the Abeta:Zn complex so that Abeta plaque could be degraded by MMP-2.	Zinc	39-41	matrix metallopeptidase 2	Homo sapiens	92-97
29172459-2	2017	GCAP5 contains two nonconserved cysteine residues (Cys15 and Cys17) that could in principle bind to biologically active transition state metal ions (Zn2+ and Fe2+).	Zinc	149-153	guanylate cyclase activator 1e	Danio rerio	0-5
25051343-5	2014	We found that the exogenous Zn(2+) in the exposure range (31.25-125.0 mumol/L) results in the overgeneration of ROS, cell cycle arrest at G2/M phases, elevation of cytosolic [Ca(2+)], inactivation of Ca(2+)-ATPase and reduction of both PMCA1 and PMCA2 in 661 W cells, and thus induces cell death.	Zinc	28-30	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	236-241
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	lipopolysaccharide induced TNF factor	Gallus gallus	123-132
25142338-4	2014	[Zn(Imdz)(2) R - OH(2)](2+) complexes (Imdz =imidazole rings; R = imidazole ring, acetic acid molecule or acetate anion) were used to partially reproduce the coordination sphere in metalloproteases (ACE, amgiotensin converting enzyme, and TLN, thermolysine) being inhibited by related compounds (i.e., silanediols).	Zinc	1-3	intercellular adhesion molecule 5	Homo sapiens	239-242
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	interleukin 4	Gallus gallus	159-163
29022694-2	2017	In the thermal treatment, the Ag2S QDs react to produce Ag nanoparticles and ZnS.	Zinc	77-80	angiotensin II receptor type 1	Homo sapiens	30-34
25068594-4	2014	Strengthening of the hydrogen bond weakens the radioactive transition of [Zn(NH2bdc)(bix)]n, which thus leads to a luminescence decrease or quenching phenomenon, meaning that the luminescent MOF [Zn(NH2bdc)(bix)]n may be applied to the detection of formaldehyde.	Zinc	74-76	lysine acetyltransferase 8	Homo sapiens	191-194
25105504-2	2014	Zinc ions (Zn2+) have been shown to antagonize the toxic effects of heavy metals such as Cd2+ in some systems.	Zinc	11-15	CD2 molecule	Bos taurus	89-92
25105504-5	2014	Zn2+ supplementation alleviated Cd2+-induced cytotoxicity and this protective effect was more obvious when cells were exposed to a lower concentration of Cd2+ (10 muM), as compared to 50 muM Cd2+.	Zinc	0-4	CD2 molecule	Bos taurus	32-35
28514971-11	2017	During preconditioning, mean liver concentrations of Co, Zn and Cu were greater (P&lt;=0.03) in AAC and INR compared with CON.	Zinc	57-59	glycine N-acyltransferase	Bos taurus	96-99
28514971-17	2017	Hence, INR and AAC increased liver concentrations of Co, Zn and Cu through preconditioning, but did not impact cattle performance and immunity responses during preconditioning and feedlot receiving.	Zinc	57-59	glycine N-acyltransferase	Bos taurus	15-18
28964831-6	2017	Molecular docking simulations suggested the novel inhibitors suppress APN activity by an alternative mechanism to Zn coordination: they interacted with residues comprising the S1 and S5" subsites of APN.	Zinc	114-116	alanyl aminopeptidase, membrane	Homo sapiens	70-73
28964831-6	2017	Molecular docking simulations suggested the novel inhibitors suppress APN activity by an alternative mechanism to Zn coordination: they interacted with residues comprising the S1 and S5" subsites of APN.	Zinc	114-116	alanyl aminopeptidase, membrane	Homo sapiens	199-202
25981743-4	2015	In mice lacking Shank2, an excitatory postsynaptic scaffolding protein, postsynaptic Zn elevation induced by clioquinol (a Zn chelator and ionophore) improves social interaction.	Zinc	85-87	SH3 and multiple ankyrin repeat domains 2	Mus musculus	16-22
25981743-4	2015	In mice lacking Shank2, an excitatory postsynaptic scaffolding protein, postsynaptic Zn elevation induced by clioquinol (a Zn chelator and ionophore) improves social interaction.	Zinc	123-125	SH3 and multiple ankyrin repeat domains 2	Mus musculus	16-22
28946747-0	2017	Force Measurement for the Interaction between Cucurbit[7]uril and Mica and Self-Assembled Monolayer in the Presence of Zn2+ Studied with Atomic Force Microscopy.	Zinc	119-123	MHC class I polypeptide-related sequence A	Homo sapiens	66-70
25967485-1	2015	Using a Cr:ZnS wafer as the saturable absorber, diode-pumped passively Q-switched mode-locking of a Tm:YAP laser at 1976 nm has been realized for the first time, to the best of our knowledge, and nearly 100% modulation depth of Q-switched mode-locking was achieved.	Zinc	11-14	Yes1 associated transcriptional regulator	Homo sapiens	103-106
25604665-6	2015	Higher percentages of CD28 expression in CD4(+) and CD8(+) T cell populations were observed in control and infected Zn-treated group as compared to untreated ones.	Zinc	116-118	Cd28 molecule	Rattus norvegicus	22-26
28946747-2	2017	Indeed, Zn2+ was observed to facilitate the self-assembly of CB[7] on the mica surface, whereas monocations, such as Na+, were less effective.	Zinc	8-12	MHC class I polypeptide-related sequence A	Homo sapiens	74-78
28692245-2	2017	Under unknown conditions, the amylin peptides aggregate to produce oligomers and fibrils, and in some cases Zn2+ ions can bind to amylin peptides to form Zn2+-aggregate complexes.	Zinc	108-112	islet amyloid polypeptide	Homo sapiens	130-136
25875377-6	2015	The eta improvement can be attributed primarily to the morphology effect of ZnO nanocones on light-trapping and effectively passivating the interface surface recombination sites of ZnO nanocones by coating with a ZnS shell layer.	Zinc	213-216	endothelin receptor type A	Homo sapiens	4-7
28692245-2	2017	Under unknown conditions, the amylin peptides aggregate to produce oligomers and fibrils, and in some cases Zn2+ ions can bind to amylin peptides to form Zn2+-aggregate complexes.	Zinc	154-158	islet amyloid polypeptide	Homo sapiens	130-136
28692245-4	2017	Therefore, it is crucial to investigate the binding sites of the Zn2+ ions in fibrillary amylin.	Zinc	65-69	islet amyloid polypeptide	Homo sapiens	89-95
28692245-5	2017	It was previously found by in vitro and simulation studies that Zn2+ ion binds to two or four His residues in the turn domain of fibrillary amylin.	Zinc	64-68	islet amyloid polypeptide	Homo sapiens	140-146
28692245-6	2017	In the current study, we present a new Zn2+ binding site in the N-terminus of fibrillary amylin with three different coordination modes.	Zinc	39-43	islet amyloid polypeptide	Homo sapiens	89-95
25831305-1	2015	Passive Q switching of a Tm:YAP solid-state laser at 1935 nm with Cr:ZnSe and Cr:ZnS polycrystalline saturable absorbers is demonstrated for the first time, to the best of our knowledge.	Zinc	69-72	Yes1 associated transcriptional regulator	Homo sapiens	28-31
28692245-7	2017	Our simulations showed that Zn2+ ions bind to polymorphic amylin fibrils with a preference to bind to four Cys residues rather than two Cys residues of two neighboring amylin monomers.	Zinc	28-32	islet amyloid polypeptide	Homo sapiens	58-64
28692245-7	2017	Our simulations showed that Zn2+ ions bind to polymorphic amylin fibrils with a preference to bind to four Cys residues rather than two Cys residues of two neighboring amylin monomers.	Zinc	28-32	islet amyloid polypeptide	Homo sapiens	168-174
28692245-9	2017	Our study provides insight into the molecular mechanisms through which Zn2+ ions that play a critical role in amylin aggregation can bind to amylin and promote amylin aggregation in T2D.	Zinc	71-75	islet amyloid polypeptide	Homo sapiens	110-116
25852435-5	2015	The efficiency of the CdS/CdSe/ZnS QD-loaded FTiR assembling CuS counter electrode cell improved from eta = 2.715% (Voc = 0.692 V, Jsc = 5.896 mA/cm(2), FF = 0.665) to eta = 0.703% (Voc = 0.665 V, Jsc = 2.108 mA/cm(2), FF = 0.501) for the QD-loaded FTiR assembling Pt counter electrode cell.	Zinc	31-34	endothelin receptor type A	Homo sapiens	102-105
28692245-9	2017	Our study provides insight into the molecular mechanisms through which Zn2+ ions that play a critical role in amylin aggregation can bind to amylin and promote amylin aggregation in T2D.	Zinc	71-75	islet amyloid polypeptide	Homo sapiens	141-147
25852435-5	2015	The efficiency of the CdS/CdSe/ZnS QD-loaded FTiR assembling CuS counter electrode cell improved from eta = 2.715% (Voc = 0.692 V, Jsc = 5.896 mA/cm(2), FF = 0.665) to eta = 0.703% (Voc = 0.665 V, Jsc = 2.108 mA/cm(2), FF = 0.501) for the QD-loaded FTiR assembling Pt counter electrode cell.	Zinc	31-34	endothelin receptor type A	Homo sapiens	168-171
28692245-9	2017	Our study provides insight into the molecular mechanisms through which Zn2+ ions that play a critical role in amylin aggregation can bind to amylin and promote amylin aggregation in T2D.	Zinc	71-75	islet amyloid polypeptide	Homo sapiens	141-147
28935959-6	2017	Cellular studies confirm the Zn2+ dependent transport of two electroneutral bicarbonate transporters, NCBE and NBCn1.	Zinc	29-33	solute carrier family 4 member 7	Homo sapiens	111-116
25651991-3	2015	The two carboxylate groups of each L(4-) anion bridge Zn(II) or Cd(II) atoms to afford a 3D porous HMOF.	Zinc	54-60	lysine acetyltransferase 8	Homo sapiens	99-103
31957297-1	2017	A new metal-organic framework (MOF), {Zn(oba)(3-bpdh)0.5 }   2 H2 O (1 Zn; oba=4,4"-oxybis(benzoic acid), 3-bpdh=N,N"-bis(1-pyridine-3-yl-ethylidene)hydrazine), was successfully assembled in a solvothermal system.	Zinc	71-73	lysine acetyltransferase 8	Homo sapiens	6-36
28672144-6	2017	This raises more questions about the relationship between Zn(II) and amylin/pramlintide: could this zinc-induced change in the complex structure be a partial explanation of the formation of oligomeric aggregates of the complex, which might be much more toxic to beta-cells than large fibrillar deposits and if so, is pramlintide the optimal choice of an antidiabetic drug?	Zinc	58-64	islet amyloid polypeptide	Homo sapiens	69-75
28852113-9	2017	The growth and coarsening of the eta" precipitates caused rapid depletion of Mg and Zn solute atoms in the MPZ.	Zinc	84-86	endothelin receptor type A	Homo sapiens	33-36
28630041-0	2017	Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.	Zinc	13-17	ryanodine receptor 2	Rattus norvegicus	46-71
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Zinc	69-73	hydrogen voltage gated channel 1	Homo sapiens	21-24
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Zinc	69-73	hydrogen voltage gated channel 1	Homo sapiens	116-119
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Zinc	177-181	hydrogen voltage gated channel 1	Homo sapiens	21-24
28607992-4	2017	TUNEL assay results showing internucleosomal DNA fragmentation in the nuclei of the cells from Zn-exposed leaves, together with an enhanced expression of three PCD marker genes (NtBI-1, Ntrboh, and NtSIPK), indicated the involvement of PCD in the formation of Zn-related lesions.	Zinc	95-97	mitogen-activated protein kinase homolog NTF4-like	Nicotiana tabacum	198-204
24980442-4	2015	Using an in vitro olfactory neuron model (the rat Odora cell line), we tested the hypothesis that Zn toxicity was caused by inhibition of the hydrogen voltage-gated channel 1(HVCN1), leading to acidosis and apoptotic cell death.	Zinc	98-100	hydrogen voltage-gated channel 1	Rattus norvegicus	142-174
24980442-4	2015	Using an in vitro olfactory neuron model (the rat Odora cell line), we tested the hypothesis that Zn toxicity was caused by inhibition of the hydrogen voltage-gated channel 1(HVCN1), leading to acidosis and apoptotic cell death.	Zinc	98-100	hydrogen voltage-gated channel 1	Rattus norvegicus	175-180
25600809-1	2015	Matrix metalloproteinases (MMPs) are zinc (Zn(2+)) and calcium (Ca(2+)) dependant endopeptidases, capable of degradation of numerous components of the extracellular matrix.	Zinc	43-49	matrix metallopeptidase 2	Rattus norvegicus	27-31
25381639-8	2015	Further, gene expressions of caspase 3 and caspase 9 were also found to be elevated after Al treatment, which however were reduced following Zn co-treatment.	Zinc	141-143	caspase 3	Rattus norvegicus	29-38
25689142-6	2015	There was an accumulation of reactive oxygen species, a release of mitochondrial cytochrome c into the cytoplasm, and an increased cellular expression of active caspase-3 in TPEN-treated cNCC compared to cNCC cultured in CTRL or TPEN + Zn media.	Zinc	236-238	caspase 3	Rattus norvegicus	161-170
24666302-4	2015	Most likely, the compounds can displace the zinc-bound water molecule of hCA XII to form a direct interaction with the Zn(2+) ion.	Zinc	119-121	carbonic anhydrase 12	Homo sapiens	73-80
26303500-5	2015	Sensitivity of Cav3.2 channels to H2S required the presence of the redox-sensitive extracellular residue H191, which is also required for tonic binding of Zn(2+) to this channel.	Zinc	155-157	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	15-21
25262292-8	2015	Dissolved/particulate partitioning was correctly assessed by WHAM-VII modeling for Cu, Pb and Zn, depicting significant differences in chemical speciation in the Fez River when compared to that in the Sebou River.	Zinc	94-96	FEZ family zinc finger 1	Homo sapiens	162-165
25220380-0	2014	TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.	Zinc	51-55	transmembrane channel like 8	Homo sapiens	0-4
25220380-0	2014	TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.	Zinc	51-55	transmembrane channel like 8	Homo sapiens	6-11
25140151-4	2014	AMPARs lacking GluA2 or containing the unedited subunit are permeable to Ca(2+) and Zn(2+).	Zinc	84-86	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	15-20
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	44-46	transmembrane channel like 8	Homo sapiens	8-12
28353208-3	2017	However, the receptor HL2 response toward Cd2+, Mg2+, Ba2+, Ca2+ besides Zn2+ and exhibits fluorescence enhancement but not enough to detection of the concentration levels of Zn2+.	Zinc	73-77	intelectin 2	Homo sapiens	22-25
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	44-46	transmembrane channel like 8	Homo sapiens	168-172
28509528-0	2017	Synthesis of Water-Soluble Ag2S Quantum Dots with Fluorescence in the Second Near-Infrared Window for Turn-On Detection of Zn(II) and Cd(II).	Zinc	123-129	angiotensin II receptor type 1	Homo sapiens	27-31
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	73-75	transmembrane channel like 8	Homo sapiens	8-12
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	73-75	transmembrane channel like 8	Homo sapiens	168-172
25517751-4	2014	In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B.	Zinc	30-32	microtubule associated protein 1 light chain 3 beta	Homo sapiens	93-97
28509528-7	2017	Furthermore, the as-synthesized Ag2S QDs showed good robustness in real sample matrix and were demonstrated to be able to detect exogenous Zn(II) in cells.	Zinc	139-141	angiotensin II receptor type 1	Homo sapiens	32-36
28509528-8	2017	These properties suggest potential applications of detection of Zn2+ in biology and Cd2+ in environment via the NIR-II fluorescent Ag2S QDs.	Zinc	64-68	angiotensin II receptor type 1	Homo sapiens	131-135
25198146-1	2014	The synthesis of a permanently porous pillared-paddlewheel metal-organic framework (MOF) was achieved through transmetalation of Zn(II) with Ni(II).	Zinc	129-135	lysine acetyltransferase 8	Homo sapiens	59-88
29745158-3	2017	Compared to elevation of the level of only Cd2+ or Zn2+, the seed germination rate under elevation of both Cd2+ and Zn2+ levels was enhanced significantly; O2-  generation rate, contents of H2O2 and MDA decreased; CAT, APX and MDAR activities increased in the last stage of Cd2+ and Zn2+ exposure.	Zinc	116-120	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	219-222
25988148-3	2014	In between the substrate-binding domain and the J-domain anchor to DnaK, DnaJ has a unique domain with four conserved CXXC motives that bind two Zn(2+) and partly contribute to polypeptide binding.	Zinc	145-147	DnaJ heat shock protein family (Hsp40) member C14	Homo sapiens	73-77
25988148-4	2014	Here, we deleted in DnaJ this Zn-binding domain, which is characteristic to type I but not of type II or III J-proteins.	Zinc	30-32	DnaJ heat shock protein family (Hsp40) member C14	Homo sapiens	20-24
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	38-40	iron regulated transporter 3	Arabidopsis thaliana	130-134
24733507-1	2014	The canonical transient receptor potential 6 (TRPC6) protein is a non-selective cation channel able to transport essential trace elements like iron (Fe) and zinc (Zn) through the plasma membrane.	Zinc	163-165	transient receptor potential cation channel subfamily C member 6	Homo sapiens	46-51
24733507-3	2014	This finding prompted us to better understand the role played by TRPC6 in Zn homeostasis.	Zinc	74-76	transient receptor potential cation channel subfamily C member 6	Homo sapiens	65-70
24733507-5	2014	TRPC6 over-expression facilitates the basal uptake of Zn and enhances the size of the pool of Zn sensitive to Baf-A.	Zinc	54-56	transient receptor potential cation channel subfamily C member 6	Homo sapiens	0-5
24733507-5	2014	TRPC6 over-expression facilitates the basal uptake of Zn and enhances the size of the pool of Zn sensitive to Baf-A.	Zinc	94-96	transient receptor potential cation channel subfamily C member 6	Homo sapiens	0-5
24733507-11	2014	Altogether, these data indicate that TRPC6 is participating in the transport of Zn and influences the Zn storage and buffering capacities of the cells.	Zinc	80-82	transient receptor potential cation channel subfamily C member 6	Homo sapiens	37-42
24733507-11	2014	Altogether, these data indicate that TRPC6 is participating in the transport of Zn and influences the Zn storage and buffering capacities of the cells.	Zinc	102-104	transient receptor potential cation channel subfamily C member 6	Homo sapiens	37-42
24967969-3	2014	Here, we determined a role of the colonocytic Zn(2+) sensing receptor, ZnR/GPR39, in mediating Zn(2+)-dependent signaling and regulating the proliferation and differentiation of colonocytes.	Zinc	46-52	G protein-coupled receptor 39	Mus musculus	75-80
24967969-4	2014	Silencing of ZnR/GPR39 expression attenuated Zn(2+)-dependent activation of ERK1/2 and AKT as well as downstream activation of mTOR/p70S6K, pathways that are linked with proliferation.	Zinc	45-51	G protein-coupled receptor 39	Mus musculus	17-22
24967969-4	2014	Silencing of ZnR/GPR39 expression attenuated Zn(2+)-dependent activation of ERK1/2 and AKT as well as downstream activation of mTOR/p70S6K, pathways that are linked with proliferation.	Zinc	45-51	mitogen-activated protein kinase 3	Mus musculus	76-82
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Zinc	21-23	G protein-coupled receptor 39	Mus musculus	25-30
26273866-4	2014	Furthermore, the involvement of metal ions (Cu(2+) and Zn(2+)) associated with hIAPP has demonstrated an effect on the aggregation pathway.	Zinc	55-61	islet amyloid polypeptide	Homo sapiens	79-84
24901737-3	2014	In this paper, an immobilized metal affinity chromatography (IMAC) assay showed that the soybean BURP protein SALI3-2 could bind soft transition metal ions (Cd(2+), Co(2+), Ni(2+), Zn(2+) and Cu(2+)) but not hard metal ions (Ca(2+) and Mg(2+)) in vitro.	Zinc	181-183	Sali3-2	Glycine max	110-117
24703409-6	2014	FI demonstrates characteristic "turn-on" behavior in the presence of Cu2+ via spirolactom ring-opening, while other metals such as Na+, K+, Ca2+, Cr3+, Mn2+, Fe3+, Fe2+, Co2+, Ni2+, Zn2+, Cd2+, Hg2+, and Ag+ did not influence FI fluorescence even at very high concentration.	Zinc	182-186	immunoglobulin kappa variable 1-35	Mus musculus	69-72
24591003-4	2014	The authors discovered that Zn supplementation inhibited high glucose (HG)-induced NRK-52E cell apoptosis by attenuating reactive oxygen species production, inhibiting HG-induced caspase-3 and caspase-9 activation, and inhibiting the release of cytochrome c from mitochondria to the cytosol.	Zinc	28-30	caspase 3	Rattus norvegicus	179-188
24591003-6	2014	Moreover, the Zn-mediated increases in Nrf2 activity were suppressed by the pharmacological inhibition of Akt or extracellular signal-regulated kinase 1/2.	Zinc	14-16	mitogen activated protein kinase 3	Rattus norvegicus	113-154
24591003-7	2014	Taken together, these findings suggest that Zn antiapoptosis capacity through the activation of Akt and ERK signal pathways leads to Nrf2 activation and, subsequently, Nrf2 target gene induction, thereby protecting the NRK-52E cells from HG-induced apoptosis.	Zinc	44-46	mitogen activated protein kinase 3	Rattus norvegicus	104-107
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	solute carrier family 30 member 5	Sus scrofa	253-260
24658588-8	2014	Hepatic TNF-alpha, IL-1beta, and IL-6 gene expression were higher in the Zn+ control group (p &lt; 0.05), and hepatic Delta6 desaturase was significantly higher in the Zn+ group (p &lt; 0.001).	Zinc	73-75	lipopolysaccharide induced TNF factor	Gallus gallus	8-17
31986605-6	2014	In this work, we show that by replacing ClO4 - with PF6 - , a series of ZnII -papx-based frameworks can be obtained.	Zinc	72-76	sperm associated antigen 17	Homo sapiens	52-55
24420568-5	2014	This indicated that PHR1 and PHO1 participate in the coregulation of Zn and Pi homeostasis.	Zinc	69-71	photolyase 1	Arabidopsis thaliana	20-24
25046762-0	2014	Approach to engineer tomato by expression of AtHMA4 to enhance Zn in the aerial parts.	Zinc	63-65	heavy metal atpase 4	Arabidopsis thaliana	45-51
25046762-1	2014	The aim of this work was to assess the potential for using AtHMA4 to engineer enhanced efficiency of Zn translocation to shoots, and to increase the Zn concentration in aerial tissues of tomato.	Zinc	101-103	heavy metal atpase 4	Arabidopsis thaliana	59-65
25046762-1	2014	The aim of this work was to assess the potential for using AtHMA4 to engineer enhanced efficiency of Zn translocation to shoots, and to increase the Zn concentration in aerial tissues of tomato.	Zinc	149-151	heavy metal atpase 4	Arabidopsis thaliana	59-65
25046762-2	2014	AtHMA4, a P1B-ATPase, encodes a Zn export protein known to be involved in the control of Zn root-to-shoot translocation.	Zinc	32-34	heavy metal atpase 4	Arabidopsis thaliana	0-6
25046762-2	2014	AtHMA4, a P1B-ATPase, encodes a Zn export protein known to be involved in the control of Zn root-to-shoot translocation.	Zinc	89-91	heavy metal atpase 4	Arabidopsis thaliana	0-6
25046762-6	2014	At 10muM Zn exposure, a higher Zn concentration was observed in leaves of AtHMA4-expressing lines compared to wild-type, which is promising in terms of Zn biofortification.	Zinc	9-11	heavy metal atpase 4	Arabidopsis thaliana	74-80
25046762-6	2014	At 10muM Zn exposure, a higher Zn concentration was observed in leaves of AtHMA4-expressing lines compared to wild-type, which is promising in terms of Zn biofortification.	Zinc	31-33	heavy metal atpase 4	Arabidopsis thaliana	74-80
25046762-6	2014	At 10muM Zn exposure, a higher Zn concentration was observed in leaves of AtHMA4-expressing lines compared to wild-type, which is promising in terms of Zn biofortification.	Zinc	31-33	heavy metal atpase 4	Arabidopsis thaliana	74-80
25046762-8	2014	Expression of this transgene AtHMA4 also resulted in distinct changes in Fe accumulation in Zn-exposed plants, and Fe/Zn-accumulation in Cd-exposed plants, even though Fe is not a substrate for AtHMA4.	Zinc	92-94	heavy metal atpase 4	Arabidopsis thaliana	29-35
25046762-8	2014	Expression of this transgene AtHMA4 also resulted in distinct changes in Fe accumulation in Zn-exposed plants, and Fe/Zn-accumulation in Cd-exposed plants, even though Fe is not a substrate for AtHMA4.	Zinc	118-120	heavy metal atpase 4	Arabidopsis thaliana	29-35
25046762-11	2014	Furthermore, results strongly suggest the importance of the up-regulation of LeCHLN in the roots of AtHMA4-expressing plants for efficient translocation of Zn to the shoots.	Zinc	156-158	heavy metal atpase 4	Arabidopsis thaliana	100-106
25046762-12	2014	Thus, the modifications of Zn/Fe/Cd translocation to aerial plant parts due to AtHMA4 expression are closely related to the alteration of the endogenous Zn-Fe-Cd cross-homeostasis network of tomato.	Zinc	27-29	heavy metal atpase 4	Arabidopsis thaliana	79-85
25046762-12	2014	Thus, the modifications of Zn/Fe/Cd translocation to aerial plant parts due to AtHMA4 expression are closely related to the alteration of the endogenous Zn-Fe-Cd cross-homeostasis network of tomato.	Zinc	153-155	heavy metal atpase 4	Arabidopsis thaliana	79-85
24880337-10	2014	Our in planta results show that OPT3 is important for leaf phloem-loading of iron and plays a key role regulating Fe, Zn, and Cd distribution within the plant.	Zinc	118-120	oligopeptide transporter	Arabidopsis thaliana	32-36
25074913-3	2014	Genetic ablation of Zip10 in early B-cell stages resulted in significant reductions in B-cell populations, and the inducible deletion of Zip10 in pro-B cells increased the caspase activity in parallel with a decrease in intracellular Zn levels.	Zinc	234-236	solute carrier family 39 member 10	Homo sapiens	137-142
25074913-5	2014	Collectively, these findings indicated that ZIP10-mediated Zn homeostasis is essential for early B-cell survival.	Zinc	59-61	solute carrier family 39 member 10	Homo sapiens	44-49
24873257-0	2014	Synthesis of porous ZnS:Ag2S nanosheets by ion exchange for photocatalytic H2 generation.	Zinc	20-23	angiotensin II receptor type 1	Homo sapiens	24-28
24873257-1	2014	ZnS:Ag2S porous nanostructures are prepared by a simple ion-exchange route using ZnS nanosheets as sacrificial templates.	Zinc	0-3	angiotensin II receptor type 1	Homo sapiens	4-8
24873257-1	2014	ZnS:Ag2S porous nanostructures are prepared by a simple ion-exchange route using ZnS nanosheets as sacrificial templates.	Zinc	81-84	angiotensin II receptor type 1	Homo sapiens	4-8
24873257-2	2014	In solutions of different Ag ion concentrations, ZnS nanosheets are partially converted to Ag2S, resulting in porous ZnS:Ag2S nanosheet composites with different pore sizes.	Zinc	49-52	angiotensin II receptor type 1	Homo sapiens	91-95
24873257-2	2014	In solutions of different Ag ion concentrations, ZnS nanosheets are partially converted to Ag2S, resulting in porous ZnS:Ag2S nanosheet composites with different pore sizes.	Zinc	49-52	angiotensin II receptor type 1	Homo sapiens	121-125
24873257-2	2014	In solutions of different Ag ion concentrations, ZnS nanosheets are partially converted to Ag2S, resulting in porous ZnS:Ag2S nanosheet composites with different pore sizes.	Zinc	117-120	angiotensin II receptor type 1	Homo sapiens	91-95
24420568-5	2014	This indicated that PHR1 and PHO1 participate in the coregulation of Zn and Pi homeostasis.	Zinc	69-71	phosphate 1	Arabidopsis thaliana	29-33
24420568-9	2014	When grown in Zn-free medium, pho1;h3 mutant plants displayed higher Pi contents in the shoots than wild-type plants.	Zinc	14-16	phosphate 1	Arabidopsis thaliana	30-34
24420575-1	2014	Ectopic expression in tobacco (Nicotiana tabacum v. Xanthi) of the export protein AtHMA4 (responsible in Arabidopsis for the control of Zn/Cd root to shoot translocation) resulted in decreased Cd uptake/accumulation in roots and shoots.	Zinc	136-138	heavy metal atpase 4	Arabidopsis thaliana	82-88
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	90-92	iron regulated transporter 3	Arabidopsis thaliana	130-134
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	90-92	iron regulated transporter 3	Arabidopsis thaliana	130-134
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	221-225	prolyl endopeptidase	Homo sapiens	202-205
28293755-3	2017	Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition.	Zinc	221-225	prolyl endopeptidase	Homo sapiens	401-404
24031023-1	2014	The interaction of Tat-conjugated PEGylated CdSe/ZnS quantum dots (QD) with the amphiphilic disulfonated aluminium phthalocyanine photosensitiser is investigated in aqueous solution and in a human breast cancer cell line.	Zinc	49-52	tyrosine aminotransferase	Homo sapiens	19-22
28358304-4	2017	Humans and Escherichia coli possess a single copy of GLYI (encoding either the Ni- or Zn-dependent form) and GLYII genes, which through MG detoxification provide protection against various pathological and disease conditions.	Zinc	86-88	hydroxyacylglutathione hydrolase	Homo sapiens	109-114
24333596-5	2014	PRL-R signaling regulates Zn metabolism in breast cells.	Zinc	26-28	prolactin receptor	Homo sapiens	0-5
27940032-1	2017	In the present work, coupled and supported NiS and ZnS onto the mechanically prepared clinoptilolite nanoparticles (NC) was prepared and characterized by XRD, FTIR, SEM-EDX, X-ray mapping, DRS, BET, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques.	Zinc	51-54	sushi repeat containing protein X-linked	Homo sapiens	189-192
24529376-3	2014	Among Zn2+ transporters, the Zn2+ importer ZIP8 was specifically upregulated in OA cartilage of humans and mice, resulting in increased levels of intracellular Zn2+ in chondrocytes.	Zinc	6-10	solute carrier family 39 member 8	Homo sapiens	43-47
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	matrix metallopeptidase 9	Mus musculus	88-92
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	matrix metallopeptidase 12	Mus musculus	94-99
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	matrix metallopeptidase 13	Mus musculus	101-106
25196974-1	2014	BACKGROUND: Aggregation of growth hormone (GH) required for its proper storage in granules is facilitated by zinc (Zn(2+)) transported by specific zinc transporters in and out of the regulated secretory pathway.	Zinc	115-121	gonadotropin releasing hormone receptor	Rattus norvegicus	27-41
25196974-1	2014	BACKGROUND: Aggregation of growth hormone (GH) required for its proper storage in granules is facilitated by zinc (Zn(2+)) transported by specific zinc transporters in and out of the regulated secretory pathway.	Zinc	115-121	gonadotropin releasing hormone receptor	Rattus norvegicus	43-45
24693334-6	2014	We thus for the first time report that an enhancement of antioxidant defence in diabetics via directly targeting heart seems to prevent diastolic dysfunction due to modulation of RyR2 macromolecular-complex thereby leading to normalized [Ca(2+)]i and [Zn(2+)]i in cardiomyocytes.	Zinc	252-258	ryanodine receptor 2	Rattus norvegicus	179-183
24126278-9	2013	The R(2) of the 14 variable model was 0.58, in which Zn and K content and the interaction of NDF x protein and Ca x P content were negatively associated with excreta moisture, and Na, protein, P, and Ca content and the interactions in contents of NDF x Na, NDF x Zn, and K x Cu were positively associated with excreta moisture content.	Zinc	263-265	neuregulin 1	Homo sapiens	93-96
23826687-0	2013	A mutation in the Arabidopsis thaliana cell wall biosynthesis gene pectin methylesterase 3 as well as its aberrant expression cause hypersensitivity specifically to Zn.	Zinc	165-167	methyl esterase 3	Arabidopsis thaliana	74-90
23726800-8	2013	This paper is the first report from an in vivo study providing evidence that beneficial Zn impact on the skeleton under exposure to Cd is related to the improvement of the bone tissue oxidative/antioxidative status and mediating the RANK/RANKL/OPG system.	Zinc	88-90	TNF superfamily member 11	Rattus norvegicus	238-243
23884414-4	2013	Here, we show that extracellular application of Zn(2+) inhibits TRPM5 activity.	Zinc	48-50	transient receptor potential cation channel subfamily M member 5	Homo sapiens	64-69
23884414-9	2013	From these results, we conclude that extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition.	Zinc	51-53	transient receptor potential cation channel subfamily M member 5	Homo sapiens	67-72
23884414-9	2013	From these results, we conclude that extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition.	Zinc	51-53	transient receptor potential cation channel subfamily M member 5	Homo sapiens	126-131
23859779-9	2013	These results indicate that the Zn-chelators ZnA-DPA (3) and ZnA-Pyr (4) exercise their apoptosis-inducing effect by mechanisms similar to TPEN (1) and PAC-1 (2), by chelation of zinc, caspase-3 activation, and ROS production.	Zinc	32-34	caspase 3	Rattus norvegicus	185-194
23664582-1	2013	HvHMA2 is a plasma membrane P1B-ATPase from barley that functions in Zn/Cd root-to-shoot transport.	Zinc	69-71	HMA2	Hordeum vulgare	0-6
23664582-6	2013	It was shown that HvHMA2 localizes to the plasma membrane of tobacco cells, and overloads the apoplast with Zn, which could explain the overall decrease in metal uptake observed.	Zinc	108-110	HMA2	Hordeum vulgare	18-24
23664582-7	2013	Despite the lower levels in the shoot, HvHMA2 transformants showed increased Zn sensitivity.	Zinc	77-79	HMA2	Hordeum vulgare	39-45
23664582-8	2013	Moreover, introduction of HvHMA2 into tobacco interfered with Fe metabolism and Fe accumulation was modified in HvHMA2-transformants in a Zn- and Cd-concentration dependent manner.	Zinc	138-140	HMA2	Hordeum vulgare	26-32
23664582-8	2013	Moreover, introduction of HvHMA2 into tobacco interfered with Fe metabolism and Fe accumulation was modified in HvHMA2-transformants in a Zn- and Cd-concentration dependent manner.	Zinc	138-140	HMA2	Hordeum vulgare	112-118
23603373-3	2013	Divalent ion zinc (Zn(2+)) is co-packaged and co-secreted with insulin and is intimately involved in the process of insulin biosynthesis and the maturation of insulin secretory granules.	Zinc	19-21	insulin	Mesocricetus auratus	63-70
23603373-3	2013	Divalent ion zinc (Zn(2+)) is co-packaged and co-secreted with insulin and is intimately involved in the process of insulin biosynthesis and the maturation of insulin secretory granules.	Zinc	19-21	insulin	Mesocricetus auratus	116-123
23603373-3	2013	Divalent ion zinc (Zn(2+)) is co-packaged and co-secreted with insulin and is intimately involved in the process of insulin biosynthesis and the maturation of insulin secretory granules.	Zinc	19-21	insulin	Mesocricetus auratus	116-123
23578765-2	2013	Using the Hv1 inhibitor Zn(2+), we found that the PMA-induced respiratory burst of human neutrophils is inhibited when assessed as extracellular production of O2(-) and H2O2, in accordance with literature studies, but, surprisingly, unaffected when measured as oxygen consumption or total (extracellular plus intracellular) H2O2 production.	Zinc	24-26	hydrogen voltage gated channel 1	Homo sapiens	10-13
23578765-3	2013	Furthermore, we show that inhibiting Hv1 with Zn(2+) results in an increased production of intracellular ROS.	Zinc	46-48	hydrogen voltage gated channel 1	Homo sapiens	37-40
23589615-3	2013	The ALS-causing mutant protein Cu(+)/Zn(+) superoxide dismutase SOD1-G93A directly enhances the activity of the main ROS-producing enzyme in microglia, NADPH oxidase 2 (NOX2), a well-known player in the pathogenesis of ALS.	Zinc	37-39	cytochrome b-245, beta polypeptide	Mus musculus	152-167
23589615-3	2013	The ALS-causing mutant protein Cu(+)/Zn(+) superoxide dismutase SOD1-G93A directly enhances the activity of the main ROS-producing enzyme in microglia, NADPH oxidase 2 (NOX2), a well-known player in the pathogenesis of ALS.	Zinc	37-39	cytochrome b-245, beta polypeptide	Mus musculus	169-173
23377617-9	2013	Although Zn-deficient cells partially upregulated GCL subunits after exposure to DA, GSH content remained low.	Zinc	9-11	glutamate-cysteine ligase catalytic subunit	Homo sapiens	50-53
23303248-1	2013	The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(II) complexes.	Zinc	82-88	RAD50 double strand break repair protein	Homo sapiens	33-38
23161861-3	2013	The mutual influence between the alkali-metal azides and the pi rings or Zn centers of the involved MOF derivatives are studied by considering the interactions both of the alkali-metal cations with model aromatic centers and of the alkali-metal azides with distinct sites of differently sized models of IRMOF-1 and IRMOF-3.	Zinc	73-75	lysine acetyltransferase 8	Homo sapiens	100-103
23711853-2	2013	Zn is also involved in many steps of high-affinity IgE receptor (FcepsilonRI)-induced mast cell (MC) activation, which is required for degranulation and cytokine production.	Zinc	0-2	Fc epsilon receptor Ia	Homo sapiens	65-76
23711853-12	2013	The kinetics and optimal conditions for FcepsilonRI cross-linking for Zn release were different from those for degranulation.	Zinc	70-72	Fc epsilon receptor Ia	Homo sapiens	40-51
23289009-8	2013	Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.	Zinc	19-21	CD19 molecule	Homo sapiens	78-82
22826039-4	2012	We found that Zn supplementation inhibited HG-induced RPMC apoptosis significantly, by attenuating reactive oxygen species (ROS) production, inhibiting HG-induced sFasR and sFasL over-expression, caspase-8 and caspase-3 activation, and inhibiting release of cytochrome c from mitochondria to the cytosol.	Zinc	14-16	caspase 3	Rattus norvegicus	210-219
22826039-6	2012	These results indicate that Zn can inhibit apoptosis in HG-induced RPMCs by several independent mechanisms, including an indirect antioxidative effect and probably by inhibition of caspase-8 and caspase-3 activation.	Zinc	28-30	caspase 3	Rattus norvegicus	195-204
23042275-1	2012	We studied the effect of heavy metal cations: Fe2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of cathepsin D in human aorta homogenate and blood serum.	Zinc	58-62	cathepsin D	Homo sapiens	100-111
22898811-4	2012	Transfection of HEK 293T cells with ZIP8 cDNA enhanced the uptake of (59)Fe and (65)Zn by 200 and 40%, respectively, compared with controls.	Zinc	84-86	solute carrier family 39 member 8	Homo sapiens	36-40
22898811-7	2012	ZIP8 also mediated the uptake of (109)Cd(2+), (57)Co(2+), (65)Zn(2+) &gt; (54)Mn(2+), but not (64)Cu (I or II).	Zinc	62-64	solute carrier family 39 member 8	Homo sapiens	0-4
22683053-6	2012	RESULTS: The data of this study revealed that the food intake, gain in body weight, serum leptin, glucose, insulin, cortisol increased with increased Zn concentration in diet.	Zinc	150-152	leptin	Rattus norvegicus	90-96
22683053-8	2012	CONCLUSION: The results of this study suggest that excessive bioavailability of Zn induces leptin resistance through increased uptake of nutrients at intestinal level, leading to the growth of the fat cells which aggravated the leptin synthesis and its release in the blood stream.	Zinc	80-82	leptin	Rattus norvegicus	91-97
22683053-8	2012	CONCLUSION: The results of this study suggest that excessive bioavailability of Zn induces leptin resistance through increased uptake of nutrients at intestinal level, leading to the growth of the fat cells which aggravated the leptin synthesis and its release in the blood stream.	Zinc	80-82	leptin	Rattus norvegicus	228-234
22744407-4	2012	The reaction of the nanocrystalline ZnS with Pb(2+) proceeds as a replacement reaction where solid PbS is formed and Zn(2+) is released into the aqueous system.	Zinc	36-38	cholinergic receptor muscarinic 3	Homo sapiens	99-102
22441041-3	2012	Zn(2+) initiates this process by activating the Gq-coupled metabotropic Zn(2+) receptor/G protein-linked receptor 39 (mZnR/GPR39).	Zinc	0-6	G protein-coupled receptor 39	Rattus norvegicus	123-128
22482529-2	2012	All MBP-NDM-1 fusion proteins were soluble; however, only one, MBP-NDM-1Delta36, exhibited high activity and bound 2 equiv of Zn(II).	Zinc	126-128	myelin basic protein	Homo sapiens	4-7
22482529-2	2012	All MBP-NDM-1 fusion proteins were soluble; however, only one, MBP-NDM-1Delta36, exhibited high activity and bound 2 equiv of Zn(II).	Zinc	126-128	myelin basic protein	Homo sapiens	63-66
22507054-7	2012	Similarly, Zn(dsc) binds weakly both to thymine bulges and hairpins with fully complementary stems.	Zinc	11-13	desmocollin 3	Homo sapiens	14-17
22806030-8	2012	The activity of the recombinant chymosin was activated by cations such as Mn(2+), Fe(3+), Mg(2+) and Na(+), but inhibited by K(+), Co(2+), Zn(2+), Ni(2+), and to a lesser extent by Cu(2+).	Zinc	139-145	chymosin	Bos taurus	32-40
22169953-2	2012	We have analyzed the effects of Mg(2+) and Zn(2+) on the conformational activation process based on NMR measurements of [methyl-(13)C]methionine DNA polymerase beta.	Zinc	43-45	DNA polymerase beta	Homo sapiens	145-164
22057392-1	2012	Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I) and is also involved in the response to hypoxia and oxidative stress.	Zinc	138-140	metal regulatory transcription factor 1	Homo sapiens	0-39
22057392-1	2012	Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I) and is also involved in the response to hypoxia and oxidative stress.	Zinc	138-140	metal regulatory transcription factor 1	Homo sapiens	41-46
22024096-5	2012	HA and FAP could significantly reduce Cd, Cu, Pb, and Zn availability in terms of water solubility in contaminated soils while minimizing soil acidification and potential risk of eutrophication associated with the application of highly soluble phosphate sources.	Zinc	54-56	fibroblast activation protein alpha	Homo sapiens	7-10
22489132-4	2012	The Ca(2+) and Zn(2+)-binding properties of S100A8/A9 have a pivotal influence on their conformation and oligomerization state, including self-assembly into homo- and heterodimers, tetramers and larger oligomers.	Zinc	15-21	S100 calcium binding protein A8	Homo sapiens	44-50
23155447-7	2012	Isolated barley chloroplasts exported Zn and Cu when supplied with Mg-ATP and this transport was inhibited by the AtHMA1 inhibitor thapsigargin.	Zinc	38-40	heavy metal atpase 1	Arabidopsis thaliana	114-120
23133519-3	2012	Application of the GPR39 agonist, Zn(2+), induced large currents and membrane depolarization in FLCs cultured from wild-type mice, but not Gpr39(-/-) mice.	Zinc	34-36	G protein-coupled receptor 39	Mus musculus	19-24
23133519-4	2012	This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression.	Zinc	5-11	chloride channel accessory 3A1	Mus musculus	88-92
23110240-3	2012	ZIP14 can transport Zn(2+) and non-transferrin-bound Fe(2+) in vitro.	Zinc	20-22	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-5
22068497-4	2011	The recombinant MaeB showed a maximum activity at pH 7.8 and 46 C. MaeB activity was dependent on the presence of Mn(2+) but was strongly inhibited by Zn(2+).	Zinc	151-153	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))	Escherichia coli str. K-12 substr. MG1655	16-20
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	75-79	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	32-37
21939532-8	2011	Interestingly, intracellular Zn2+ levels in APP-PS1 mice and human AD hippocampus are reduced along with a reduction in synapse density and synaptic ProSAP2/Shank3 and Shank1 protein levels.	Zinc	29-33	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	168-174
21621258-5	2011	Recent evidence suggests that TRPML1 is involved in Fe(2+), Ca(2+) and Zn(2+) transport across the lysosomal membrane, ascribing novel physiological roles to this ion channel, and perhaps to its relatives TRPML2 and TRPML3 and illuminating poorly understood aspects of lysosomal function.	Zinc	71-77	mucolipin TRP cation channel 3	Homo sapiens	216-222
22032146-3	2011	RESULT: The contents of Cu and S elements were increased, while the content of Zn element was decreased in Paeoniae Radix Alba after sulfur-fumigated process compared with the samples dried in the sun.	Zinc	79-81	afamin	Homo sapiens	122-126
21598944-4	2011	The energetics of desolvated MOF-5 per mole of Zn falls in line with trends relating the enthalpy of inorganic porous materials (zeolites, zeotypes, and mesoporous materials) to molar volume.	Zinc	47-49	lysine acetyltransferase 8	Homo sapiens	29-32
21312334-4	2011	Several new zinc(II) or copper(II) complexes demonstrated potent anti-HIV activity, strong CXCR4-binding activity, and significant inhibitory activity against Ca(2+) mobilization induced by CXCL12 stimulation.	Zinc	12-20	C-X-C motif chemokine ligand 12	Homo sapiens	190-196
21262225-6	2011	Regardless of the counter anion used, Zn(2+) and Cu(2+) interact with alpha(1A)-adrenoceptor with apparent affinities in the low micromolar range.	Zinc	38-40	adrenoceptor alpha 1A	Homo sapiens	70-92
21445361-5	2011	We conclude that SLC39A14 facilitates GPCR-mediated cAMP-CREB signaling by suppressing the basal PDE activity, and that this is one mechanism for Zn"s involvement in systemic growth processes.	Zinc	146-148	solute carrier family 39 (zinc transporter), member 14	Mus musculus	17-25
21103564-1	2011	Zn(II)-containing metal-organic framework (MOF) [Zn(4)(dmf)(ur)(2)(ndc)(4)] (ndc(2-) = 2,6-naphtalenedicarboxylate, ur = urotropin, dmf = N,N"-dimethylformamide) was synthesized and characterized by X-ray crystallography and gas sorption analysis.	Zinc	0-6	lysine acetyltransferase 8	Homo sapiens	18-47
21423774-0	2011	Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator Noccaea caerulescens.	Zinc	44-46	heavy metal atpase 4	Arabidopsis thaliana	26-30
21423774-2	2011	Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd hyperaccumulation in A. halleri.	Zinc	58-60	heavy metal atpase 4	Arabidopsis thaliana	74-78
21217644-3	2011	Here, we report that Zn(2+) ions, which are highly enriched within the postsynaptic density (PSD), are able to influence the recruitment of ProSAP/Shank proteins to PSDs in a family member-specific manner during the course of synaptogenesis and synapse maturation.	Zinc	21-23	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	147-152
21217644-5	2011	Furthermore, depletion of synaptic Zn(2+) along with the knockdown of zinc-insensitive Shank1 causes the rapid disintegration of PSDs and the loss of several postsynaptic molecules including Homer1, PSD-95 and NMDA receptors.	Zinc	35-37	discs large MAGUK scaffold protein 4	Homo sapiens	199-205
20672323-11	2011	Inhibitor studies indicated that the galectin-3 cleavage activity in seminal plasma is a Zn(2+) sensitive, serine protease.	Zinc	89-95	galectin 3	Homo sapiens	37-47
21155538-4	2011	Two 1D chains are then interlinked via the connectivity between the Zn(II) ions and anti-BPE liagnds to complete the 1D ladderlike MOF.	Zinc	68-74	lysine acetyltransferase 8	Homo sapiens	131-134
21869566-8	2011	In contrast, addition of Zn(2+), an essential metal co-factor of NT5E activity, prevented SNP from inhibiting NT5E.	Zinc	25-27	5'-nucleotidase ecto	Homo sapiens	65-69
21869566-8	2011	In contrast, addition of Zn(2+), an essential metal co-factor of NT5E activity, prevented SNP from inhibiting NT5E.	Zinc	25-27	5'-nucleotidase ecto	Homo sapiens	110-114
21869566-9	2011	These results suggest that SNP disrupts a critical Zn(2+)-dependent enzyme activity and might be useful as a pharmacological tool for inhibiting NT5E.	Zinc	51-53	5'-nucleotidase ecto	Homo sapiens	145-149
20947945-1	2010	A new process for making single crystalline undoped and Ga-doped ZnS nanowires with simple evaporation and condensation procedures on Si and GaN is introduced.	Zinc	65-68	gigaxonin	Homo sapiens	141-144
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Zinc	30-32	heavy metal atpase 4	Arabidopsis thaliana	5-11
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Zinc	30-32	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	47-51
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Zinc	168-170	heavy metal atpase 4	Arabidopsis thaliana	5-11
20650903-5	2010	We conclude that the C-terminal domain of AtHMA4 serves a dual role as Zn(2+) and Cd(2+) chelator (sensor) and as a regulator of the efficiency of Zn(2+) and Cd(2+) export.	Zinc	71-73	heavy metal atpase 4	Arabidopsis thaliana	42-48
20650903-5	2010	We conclude that the C-terminal domain of AtHMA4 serves a dual role as Zn(2+) and Cd(2+) chelator (sensor) and as a regulator of the efficiency of Zn(2+) and Cd(2+) export.	Zinc	147-149	heavy metal atpase 4	Arabidopsis thaliana	42-48
20492471-7	2010	RESULTS: Zn2(+) -containing PS potently inhibited extrinsic FXase in the presence of saturating phospholipids, independently of TFPI, whereas inhibition of extrinsic FXase by Zn2(+) -deficient PS required TFPI.	Zinc	9-15	tissue factor pathway inhibitor	Homo sapiens	205-209
20608701-5	2010	EDA-SAMMS and AC-CH(2)-EDA demonstrated rapid Cu(2+) sorption kinetics (minutes) and good sorption capacities (26 and 17 mg Cu/g sorbent, respectively) in seawater, whereas Phen-FMC had excellent selectivity for Cu(2+) over other metal ions (e.g., Ca(2+), Fe(2+), Ni(2+), and Zn(2+)) and was able to achieve Cu below the EPA recommended levels for river and sea waters.	Zinc	276-278	ectodysplasin A	Homo sapiens	0-3
20553223-6	2010	Zn and/or PQ exposure increased gene expression of DAT, CYP2E1, GSTA4-4, MT-I and MT-II, but reduced the expression of VMAT-2.	Zinc	0-2	solute carrier family 6 member 3	Rattus norvegicus	51-54
27940032-1	2017	In the present work, coupled and supported NiS and ZnS onto the mechanically prepared clinoptilolite nanoparticles (NC) was prepared and characterized by XRD, FTIR, SEM-EDX, X-ray mapping, DRS, BET, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques.	Zinc	51-54	delta/notch like EGF repeat containing	Homo sapiens	194-197
27801555-3	2017	EXPERIMENTAL DESIGN AND RESULTS: Here, we explored further and found that the zinc (Zn) importer Zip8 was stably abolished in these cells along with a marked decrease of Cd and Zn accumulation.	Zinc	84-86	solute carrier family 39 member 8	Homo sapiens	97-101
20188440-11	2010	The above isoforms also displayed differences in preference towards a mixture of ADP, GDP, dGDP, TDP, dCDP, CDP and UDP in the presence of Cu(2+), Zn(2+), Mg(2+), Mn(2+), Ni(2+), Ca(2+), Hg(2+) or Co(2+).	Zinc	147-149	cut like homeobox 1	Homo sapiens	103-106
20229093-8	2010	Upon reconstitution with either Fe(II) or Zn(II), NZF-1-DF binds selectively and tightly (nanomolar affinity) to its target beta-RARE DNA sequence, whereas apo-NZF-1-DF does not bind to DNA and instead aggregates.	Zinc	42-48	myelin transcription factor 1 like	Homo sapiens	50-55
28176522-3	2017	Our results identify that full miscibility of most Cd1-xZnxOyS1-y compositions and even binaries like Zn(O,S) is outside typical photovoltaic processing conditions.	Zinc	56-58	CD1c molecule	Homo sapiens	51-54
19768661-6	2010	Here we report that free Zn(2+) disrupts cellular redox status through inhibition of glutathione reductase, and induces apoptosis by redox-mediated inhibition of the mitochondrial adenine nucleotide transporter (ANT).	Zinc	25-27	glutathione-disulfide reductase	Homo sapiens	85-106
28116384-0	2017	Effect of Zn substitution on the magnetic and magnetocaloric properties of Cd1-xZnxCr2Se4 spinel.	Zinc	10-12	CD1c molecule	Homo sapiens	75-78
20039701-4	2010	The results of (1)H NMR, potentiometric pH, UV-vis, and fluorescent titrations showed that L(6) rapidly forms a 1:1 complex with Zn(2+) (Zn(H(-1)L(6))), the dissociation constant of which is 50 fM at pH 7.4.	Zinc	129-131	transmembrane 4 L six family member 1	Homo sapiens	91-95
20039701-4	2010	The results of (1)H NMR, potentiometric pH, UV-vis, and fluorescent titrations showed that L(6) rapidly forms a 1:1 complex with Zn(2+) (Zn(H(-1)L(6))), the dissociation constant of which is 50 fM at pH 7.4.	Zinc	137-139	transmembrane 4 L six family member 1	Homo sapiens	91-95
20039701-4	2010	The results of (1)H NMR, potentiometric pH, UV-vis, and fluorescent titrations showed that L(6) rapidly forms a 1:1 complex with Zn(2+) (Zn(H(-1)L(6))), the dissociation constant of which is 50 fM at pH 7.4.	Zinc	137-139	transmembrane 4 L six family member 1	Homo sapiens	145-149
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	28-30	transmembrane 4 L six family member 1	Homo sapiens	36-40
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	28-30	transmembrane 4 L six family member 1	Homo sapiens	84-88
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	28-30	transmembrane 4 L six family member 1	Homo sapiens	84-88
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	150-152	transmembrane 4 L six family member 1	Homo sapiens	36-40
27349787-8	2017	Results indicated that PAC-Ep was efficient in removing nZnO and Zn2+, which leads to more than 95 % particles, 50-60 % natural organic matter (NOM) removed, and 35 % of resolved heavy metal ion adsorbing-chelation.	Zinc	65-69	furin, paired basic amino acid cleaving enzyme	Homo sapiens	23-29
20039701-5	2010	The fluorescent emission of Zn(H(-1)L(6)) at 478 nm is 32 times as large as that of L(6) (excitation at 370 nm), and the fluorescent quantum yield of Zn(H(-1)L(6)) (Phi(F) = 0.41) is much greater than that of Zn(H(-1)L(5)) (Phi(F) = 0.044).	Zinc	150-152	transmembrane 4 L six family member 1	Homo sapiens	36-40
20039701-6	2010	The BS-caged-L(6) was reactivated by hydrolysis of the benzenesulfonyl moiety more rapidly (completes in 30 min at pH 7.4 at 37 degrees C) than BS-caged-L(5), presumably enabling the practical detection of Zn(2+) in sample solutions and living cells.	Zinc	206-208	transmembrane 4 L six family member 1	Homo sapiens	13-17
20092568-0	2009	Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.	Zinc	0-4	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	15-20
28190830-0	2017	Forster Resonance Energy Transfer Mediated Photoluminescence Quenching in Stoichiometrically Assembled CdSe/ZnS Quantum Dot-Peptide Labeled Black Hole Quencher Conjugates for Matrix Metalloproteinase-2 Sensing.	Zinc	108-111	matrix metallopeptidase 2	Homo sapiens	175-201
20092568-4	2009	Here, we show that neuronal free Zn(2+)also plays a critical role in the ischemic modulation of Kv2.1.	Zinc	33-35	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	96-101
20092568-7	2009	Zn(2+)chelation during ischemia also blocked Kv2.1 declustering.	Zinc	0-2	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	45-50
27891752-2	2016	Herein, we report a metal-organic framework (MOF) assembled from ZnII ions, 1,4-benzenedicarboxylate, and a hydrophobic carborane-based linker.	Zinc	65-69	lysine acetyltransferase 8	Homo sapiens	20-49
20092568-9	2009	Therefore, a calcineurin-independent rise in neuronal free Zn(2+) is critical in altering Kv2.1 channel activity and localization following ischemia.	Zinc	59-61	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	90-95
20092568-10	2009	The identification of Zn(2+) in mediating ischemic modulation of Kv2.1 may lead to a better understanding of cellular adaptive responses to injury.	Zinc	22-24	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	65-70
26944347-3	2016	Results from cyclic voltammetric and FI amperometric measurements have revealed that GDH/ZnS-CdS/MWCNT/GCE is capable of signaling photoelectrocatalytic activity toward NADH when the surface of enzyme modified electrode was irradiated with a light source (250W Halogen lamp).	Zinc	89-92	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	85-88
19813714-1	2009	Zn(2+) ions react with 3,5-pyridinedicarboxylate (pydc) to form a new metal-organic framework (MOF), [Zn(pydc)(dma)] (dma = N,N"-dimethylacetamide), based on a noninterpenetrating (10,3)-a topology.	Zinc	0-2	lysine acetyltransferase 8	Homo sapiens	70-100
27808280-2	2016	A remarkable example is the Rad50 zinc hook domain, which is highly conserved and facilitates the Zn2+-mediated homodimerization of Rad50 proteins.	Zinc	98-102	RAD50 double strand break repair protein	Homo sapiens	28-33
19616630-6	2009	Mn-SOD expression in the liver and kidney were significantly modulated by injection of LPS (1, 5, or 10 microg g(-1) body weight), Edwardsiella tarda challenge (5 x 10(3) or 5 x 10(5) cells/fish), and heavy metal exposure (Cd, Cu, or Zn at 5 microM).	Zinc	234-236	superoxide dismutase 2	Homo sapiens	0-6
27808280-2	2016	A remarkable example is the Rad50 zinc hook domain, which is highly conserved and facilitates the Zn2+-mediated homodimerization of Rad50 proteins.	Zinc	98-102	RAD50 double strand break repair protein	Homo sapiens	132-137
19589782-4	2009	In support of both cell-based and animal work showing that the cytotoxic effect of ETPs is reduced by the addition of Zn(2+) through an unknown mechanism, our mechanistic studies reveal that ETPs react with p300, causing zinc ion ejection.	Zinc	118-120	E1A binding protein p300	Homo sapiens	207-211
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (&gt;100 mM).	Zinc	76-80	helicase for meiosis 1	Homo sapiens	4-12
27642808-3	2016	Importantly, the Zn-doped CoSe2/CFC electrode exhibited an obviously enhanced catalytic activity for OER in 1 M KOH aqueous solution compared with CoSe2/CFC, showing a small overpotential of 356 mV for a current density of 10 mA cm-2, a small Tafel slope of 88 mV dec-1, and an excellent stability.	Zinc	17-19	deleted in esophageal cancer 1	Homo sapiens	264-269
19789157-7	2009	In contact with sea water only 0.29 mg kg-1 of V, 0.04 mg kg-1 of Cr, 0.07 mg kg-1 of Ni, 0.33 mg kg-1 of Cu, 0.67 mg kg-1 of Zn and 0.06 mg kg-1 of Pb could be remobilised from sediment material into the water column.	Zinc	126-128	scheggia	Drosophila melanogaster	16-19
19490425-6	2009	Zn treatment dramatically increased the expression of the metallothionein (Mt), and modestly increased the expression of acute-phase protein genes (ceruloplasmin, Stat3, egr1, Cxc chemokines and heat-shock proteins).	Zinc	0-2	ceruloplasmin	Rattus norvegicus	148-161
27567443-5	2016	In addition, Zn deficient cells significantly triggered intracellular ROS level and develop oxidative stress induced DNA damage; it was confirmed by elevated expression of CYP1A, GPX, GSK3beta and TNF-alpha gene.	Zinc	13-15	glycogen synthase kinase 3 beta	Homo sapiens	184-192
19572618-2	2009	A mixture of spherical and tripod nanostructures were obtained only in the one-step reaction (ZC3), where the Zn- and Cd-precursors were reacted simultaneously, rather than in the two step reactions (ZC1 and ZC2), where largely spherical nanostructures were observed.	Zinc	110-112	misshapen like kinase 1	Homo sapiens	94-97
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	proline rich protein BstNI subfamily 1	Homo sapiens	65-69
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	proline rich protein BstNI subfamily 1	Homo sapiens	163-167
27535342-1	2016	The addition of Sn and Zn ions to [Ge9 ] clusters by reaction of [Ge9 ]4- with SnPh2 Cl2 , ZnCp*2 (Cp*=pentamethylcyclopentadienyl), or Zn2 [HC(Ph2 P=NPh)2 ]2 is reported.	Zinc	23-25	syntaphilin	Homo sapiens	79-83
19413286-0	2009	Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme.	Zinc	38-44	hydroxyacylglutathione hydrolase	Homo sapiens	6-19
19413286-2	2009	Recombinant human Glx2 tightly binds nearly 1 equiv each of Zn(II) and Fe.	Zinc	60-66	hydroxyacylglutathione hydrolase	Homo sapiens	18-22
19413286-5	2009	NMR studies show that Fe(II) binds to the consensus Zn(2) site in Glx2 and that this site can also bind Co(II) and Ni(II), suggesting that Zn(II) binds to the consensus Zn(1) site.	Zinc	52-57	hydroxyacylglutathione hydrolase	Homo sapiens	66-70
19413286-7	2009	Steady-state and pre-steady-state kinetic studies show that Glx2 containing only 1 equiv of Zn(II) is catalytically active and that the metal ion in the consensus Zn(2) site has little effect on catalytic activity.	Zinc	92-98	hydroxyacylglutathione hydrolase	Homo sapiens	60-64
27520940-3	2016	This organometallic inhibitor incorporates adenosine and zinc(II)cyclen within its core scaffold and inhibits UBA5 noncompetitively and selectively over other E1 enzymes and a panel of human kinases.	Zinc	57-65	ubiquitin like modifier activating enzyme 5	Homo sapiens	110-114
19413286-8	2009	Taken together, these studies suggest that Glx2 contains a Fe(II)Zn(II) center in vivo but that the catalytic activity is due to Zn(II) in the Zn(1) site.	Zinc	65-71	hydroxyacylglutathione hydrolase	Homo sapiens	43-47
30155193-9	2016	On the other hand, metal-free hIAPP and Zn(ii)-associated hIAPP monomers generate relatively less toxic aggregates that eventually grow into fibrils.	Zinc	40-46	islet amyloid polypeptide	Homo sapiens	58-63
26637494-6	2016	Results showed that dietary supplementation of Zn reduced the gene expression of hypothalamic ghrelin and tumor necrosis factor alpha (TNF-alpha) (P &lt; 0.05).	Zinc	47-49	lipopolysaccharide induced TNF factor	Gallus gallus	106-133
19339245-10	2009	Using electrospray ionization mass spectrometry and inductively coupled plasma-atomic emission spectrometry analysis, we determined that the RING0, RING1, IBR, and RING2 domains each bind two Zn(2+) ions, the first observation of an E3 ligase with the ability to bind eight metal ions.	Zinc	192-194	ring finger protein 1	Homo sapiens	148-153
26637494-6	2016	Results showed that dietary supplementation of Zn reduced the gene expression of hypothalamic ghrelin and tumor necrosis factor alpha (TNF-alpha) (P &lt; 0.05).	Zinc	47-49	lipopolysaccharide induced TNF factor	Gallus gallus	135-144
26637494-10	2016	This study shows that dietary Zn supplementation promoted orexigenic appetite regulatory peptides and reduced the expression of the inflammatory cytokine TNF-alpha in the hypothalamus of Salmonella-challenged broilers.	Zinc	30-32	lipopolysaccharide induced TNF factor	Gallus gallus	154-163
19240037-8	2009	Whole cell voltage-clamp recordings show that Zn(2+) inhibition of agonist-evoked NMDA receptor currents of NR1/NR2A-transfected HEK 293 cells and cultured cortical neurons is significantly reduced by plasmin treatment.	Zinc	46-48	plasminogen	Homo sapiens	201-208
30155058-4	2016	The centrosomal STIL protein bound Zn2+ ions via both its structured N-terminal domain (NTD) and disordered central region (IDR).	Zinc	35-39	STIL centriolar assembly protein	Homo sapiens	16-20
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Zinc	95-97	plasminogen	Homo sapiens	13-20
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Zinc	95-97	plasminogen	Homo sapiens	84-91
19240037-10	2009	The relief of Zn(2+) inhibition by plasmin occurs in PAR1(-/-) cortical neurons and thus is independent of interaction with protease-activated receptors.	Zinc	14-16	plasminogen	Homo sapiens	35-42
19240037-11	2009	These results suggest that plasmin can directly interact with NMDA receptors, and plasmin may increase NMDA receptor responses through disruption or removal of the amino-terminal domain and relief of Zn(2+) inhibition.	Zinc	200-202	plasminogen	Homo sapiens	82-89
30155058-6	2016	We suggest that by binding Zn2+ STIL acquires a different conformation, which allows its oligomerization and induces its activity.	Zinc	27-31	STIL centriolar assembly protein	Homo sapiens	32-36
27166256-8	2016	In every model system studied, HSeO3- uptake is tightly associated with ZIP8 protein levels and sufficient Zn2+ and HCO3- concentrations, suggesting that the ZIP8-mediated electroneutral complex transported contains three ions: Zn2+/(HCO3-)(HSeO3-).	Zinc	107-111	solute carrier family 39 member 8	Homo sapiens	158-162
27166256-8	2016	In every model system studied, HSeO3- uptake is tightly associated with ZIP8 protein levels and sufficient Zn2+ and HCO3- concentrations, suggesting that the ZIP8-mediated electroneutral complex transported contains three ions: Zn2+/(HCO3-)(HSeO3-).	Zinc	228-232	solute carrier family 39 member 8	Homo sapiens	158-162
20183605-1	2009	In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4") oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates.	Zinc	160-162	cytidine deaminase	Homo sapiens	83-101
27172138-1	2016	Investigation of genetic determinants of Cd tolerance in the Zn/Cd hyperaccumulator Arabidopsis halleri allowed the identification of the vacuolar Ca(2+)/H(+) exchanger encoding CAX1 gene.	Zinc	61-63	cation exchanger 1	Arabidopsis thaliana	178-182
20183605-1	2009	In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4") oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates.	Zinc	160-162	cytidine deaminase	Homo sapiens	103-106
19420558-0	2009	Surface doping for photocatalytic purposes: relations between particle size, surface modifications, and photoactivity of SnO(2):Zn2+ nanocrystals.	Zinc	128-132	strawberry notch homolog 1	Homo sapiens	121-124
19420558-5	2009	It is found that Zn(2+) doped SnO(2) showed excellent activity toward photodegradation of methylene blue solution under UV light irradiation.	Zinc	17-19	strawberry notch homolog 1	Homo sapiens	30-33
19420558-6	2009	These observations were interpreted in terms of the Zn(2+) doping at the surface sites of SnO(2) nanoparticles and the relevant defects that have increased the surface active sites and moreover improved the ratio of surface charge carrier transfer rate to the electron-hole recombination rate.	Zinc	52-54	strawberry notch homolog 1	Homo sapiens	90-93
19036834-2	2009	In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1.	Zinc	258-260	heavy metal atpase 3	Arabidopsis thaliana	143-149
19036834-4	2009	Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd.	Zinc	40-42	heavy metal atpase 3	Arabidopsis thaliana	85-91
19036834-6	2009	Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants.	Zinc	93-95	heavy metal atpase 3	Arabidopsis thaliana	38-44
19036834-7	2009	Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.	Zinc	70-72	heavy metal atpase 3	Arabidopsis thaliana	6-12
18975044-5	2009	Zn-deficient mice showed exaggerated stress-evoked immediate-early gene expression in the amygdala which was normalised following DMI treatment.	Zinc	0-2	jun proto-oncogene	Mus musculus	51-66
19858116-6	2009	Total nutrient accumulation was similar between lines, but grain Fe, Zn, and N were at lower concentrations in the NAM knockdown line.	Zinc	69-71	NAC domain-containing protein 20	Triticum aestivum	115-118
18720954-2	2008	The present strategy utilizes the large difference in solubility between ZnS and other metal sulfides (Ag2S, PbS, CuS, Cu2S, Bi2S3, and Sb2S3) for the effective transformation and shows mild growth conditions and good reproducibility.	Zinc	73-76	angiotensin II receptor type 1	Homo sapiens	103-107
18774338-4	2008	The association of single nucleotide polymorphisms in genes encoding ZnT-8 and MT with DM2 has drawn attention to the relevance of Zn homeostasis for insulin secretory capacity and responsiveness.	Zinc	69-71	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	87-90
18774338-5	2008	Here, we propose that potential mechanisms leading to altered subcellular Zn distribution rather than deficiency might be important in DM2.	Zinc	74-76	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	135-138
18463798-5	2008	Alternatively, it might be that Zrt2p was degraded by endocytosis in the absence of Al(3+) and Al(3+) interfered with this process, resulting in enhanced Zn(2+) accumulation.	Zinc	154-160	low-affinity Zn(2+) transporter ZRT2	Saccharomyces cerevisiae S288C	32-37
27028368-10	2016	Zn could delay the progression of obesity-related kidney disease by down-regulating P38 MAPK-mediated inflammation.	Zinc	0-2	mitogen-activated protein kinase 14	Mus musculus	84-92
26940795-5	2016	During the early stage of exposure for 6 h, the 8 mg L(-1) Zn exposure sharply increased mRNA levels of Cu/Zn-SOD, CAT, GPx1b, Nrf2, and Keap1, whereas, the 4 mg L(-1) Zn exposure did not significantly affect the expression of these genes.	Zinc	59-61	catalase	Larimichthys crocea	115-118
27031885-1	2016	The combination of zero-dimensional (0D) colloidal CdSe/ZnS quantum dots with tin disulfide (SnS2), a two-dimensional (2D)-layered metal dichalcogenide, results in 0D-2D hybrids with enhanced light absorption properties.	Zinc	56-59	sodium voltage-gated channel alpha subunit 11	Homo sapiens	93-97
27031885-2	2016	These 0D-2D hybrids, when exposed to light, exhibit intrahybrid nonradiative energy transfer from photoexcited CdSe/ZnS quantum dots to SnS2.	Zinc	116-119	sodium voltage-gated channel alpha subunit 11	Homo sapiens	136-140
26329999-9	2016	The expressions of apoptotic proteins caspase 12 and cleaved caspase 9 and caspase 3 were also significantly controlled in ZnS-NPs-treated primary MRPE cells when comparing with thapsigargin- and hydrogen peroxide-treated cells.	Zinc	123-126	caspase 12	Mus musculus	38-48
26329999-9	2016	The expressions of apoptotic proteins caspase 12 and cleaved caspase 9 and caspase 3 were also significantly controlled in ZnS-NPs-treated primary MRPE cells when comparing with thapsigargin- and hydrogen peroxide-treated cells.	Zinc	123-126	caspase 9	Mus musculus	61-70
26541645-5	2016	The size of the ZIS QDs and their crystal lattice constant increased with increasing In incorporation, but they maintained the cubic sphalerite phase of ZnS, rather than the hexagonal phase typical of ZnIn2 S4 .	Zinc	153-156	zinc finger RANBP2-type containing 2	Homo sapiens	16-19
26879852-1	2016	The roles of protein undernutrition as well as selenium (Se) and zinc (Zn) supplementation on the ability of calmodulin (CaM) to activate erythrocyte ghost membrane (EGM) Ca(2+)-ATPase and the calmodulin genes and protein expressions in rat"s cortex and cerebellum were investigated.	Zinc	71-73	calmodulin 1	Rattus norvegicus	109-119
26879852-5	2016	Se or Zn supplementation improved the ability of Ca(2+)/CaM to activate EGM Ca(2+)-ATPase and protein expressions.	Zinc	6-8	calmodulin 1	Rattus norvegicus	56-59
26879852-8	2016	In conclusion, it is postulated that Se and Zn might be beneficial antioxidants in protecting against neuronal dysfunction resulting from reduced level of calmodulin such as present in protein undernutrition.	Zinc	44-46	calmodulin 1	Rattus norvegicus	155-165
26497333-6	2016	Furthermore, Zn(ASA)2 significantly increased the myocardial mRNA-expression of superoxide dismutase-1, glutathione peroxidase-4 and decreased the level of Na(+)/K(+)/ATPase.	Zinc	13-15	glutathione peroxidase 4	Rattus norvegicus	104-128
26845700-8	2016	RESULTS: Exposure to IL-17 and TNF-alpha enhanced expression of the Zn-importer ZIP-8, regardless of the concentration of Zn in the culture medium.	Zinc	68-70	solute carrier family 39 member 8	Homo sapiens	80-85
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Zinc	111-113	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	31-36
18543905-1	2008	Color-tunable Zn(II) complexes of the type Zn( N,O-OPh (OxZ)ArX) 2 ( 5), where the ligand consists of an oxazolylphenolate ion connected at the 4-position by a 2,4-substituted aryl functional group with X = NMe 2 a, OMe b, Ph c, Cl d, F 2 e, and CN f, were prepared.	Zinc	14-16	solute carrier family 25 member 3	Homo sapiens	223-227
18800729-2	2008	The analyzing conditions of PAN chelating reaction with three metal ions such as Cu2+, Cd2+ and Zn2+, the spectral properties at maximum absorption wavelength of these chelate compounds, pH effect and reaction time and so on were studied.	Zinc	96-100	adenosine deaminase 2	Homo sapiens	28-31
18451058-6	2008	These genes (CTA4, ASG1 and CTF1) encode proteins with Zn(2)-Cys(6)-type zinc finger motifs in their N-terminal domains.	Zinc	55-57	Asg1p	Saccharomyces cerevisiae S288C	19-23
18497135-1	2008	The competitive binding of Cd2+ and Zn2+ by the phytochelatin (gamma-Glu-Cys)4-Gly (PC4) has been examined using several techniques.	Zinc	36-40	keratin 6B	Homo sapiens	84-87
17671992-6	2007	The NMDA (10 microM) response was blocked by 1 nM Zn(2+) and 1 microM ifenprodil, compatible with the involvement of a NR1/NR2A/NR2B assembly, although the presence of two separate receptor populations, i.e., NR1/NR2A and NR1/NR2B, cannot be excluded.	Zinc	50-52	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	119-122
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Zinc	130-134	transient receptor potential cation channel subfamily M member 5	Homo sapiens	62-67
17215247-6	2007	Zn(II) binding in Cox4 is, therefore, important for the stability of the complex.	Zinc	0-6	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	18-22
17256929-3	2007	In the presence of the triaza ligand:Zn2+ complex, the change from water to methanol and then to ethanol brings about a mechanism where two molecules of the complex, suggested as EtOH:Zn2+:[12]aneN3 and its basic form, EtO-:Zn2+:[12]aneN3, bind to HPNPP and catalyze its decomposition with a rate constant of kcat of 0.13 s(-1) at s(s)pH 7.1.	Zinc	37-41	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	179-182
17256929-3	2007	In the presence of the triaza ligand:Zn2+ complex, the change from water to methanol and then to ethanol brings about a mechanism where two molecules of the complex, suggested as EtOH:Zn2+:[12]aneN3 and its basic form, EtO-:Zn2+:[12]aneN3, bind to HPNPP and catalyze its decomposition with a rate constant of kcat of 0.13 s(-1) at s(s)pH 7.1.	Zinc	37-40	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	179-182
17256929-3	2007	In the presence of the triaza ligand:Zn2+ complex, the change from water to methanol and then to ethanol brings about a mechanism where two molecules of the complex, suggested as EtOH:Zn2+:[12]aneN3 and its basic form, EtO-:Zn2+:[12]aneN3, bind to HPNPP and catalyze its decomposition with a rate constant of kcat of 0.13 s(-1) at s(s)pH 7.1.	Zinc	184-188	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	179-182
17008051-7	2007	Mutational analysis pointed to Ser 536 of p65/RelA as the determinant of Zn2+-induced NF-kappaB transactivation in BEAS-2B cells.	Zinc	73-77	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
17008051-7	2007	Mutational analysis pointed to Ser 536 of p65/RelA as the determinant of Zn2+-induced NF-kappaB transactivation in BEAS-2B cells.	Zinc	73-77	RELA proto-oncogene, NF-kB subunit	Homo sapiens	46-50
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	66-70	RELA proto-oncogene, NF-kB subunit	Homo sapiens	79-82
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	66-70	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-87
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	218-222	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-87
17266955-0	2007	The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase.	Zinc	34-38	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	42-62
17266955-1	2007	EXAFS analysis of Zn binding site(s) in bovine-heart cytochrome c oxidase and characterization of the inhibitory effect of internal zinc on respiratory activity and proton pumping of the liposome reconstituted oxidase are presented.	Zinc	18-20	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	53-73
17114218-9	2007	Binding of the polyamines and Zn(II) to the S1S2 domain of the GluR2 subunit was not observed.	Zinc	30-36	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	63-68
16953504-6	2006	The important vulcanization accelerator mercaptobenzothiazole (C(7)H(5)NS(2), MBT) containing several donor sites reacts with the Zn(4)O(4) cluster with proton transfer from the NH group to one of the oxygen atoms of ZnO, and in addition the exocyclic thiono sulfur atom and the nitrogen atom coordinate to one and the same zinc atom, resulting in a binding energy of -247 kJ mol(-1).	Zinc	130-132	proteinase 3	Homo sapiens	78-81
16953504-7	2006	A second isomer of [(MBT)Zn(4)O(4)] with a strong O--HN hydrogen bond rather than a Zn--N bond is only slightly less stable (binding energy -243 kJ mol(-1)).	Zinc	25-27	proteinase 3	Homo sapiens	21-24
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Zinc	135-137	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	31-36
26481949-7	2016	After the additional adjustment for energy intake, whole nut consumers had higher intakes of dietary fibre, vitamin E, folate, Cu, Mg, K, P and Zn (all P&lt;=0 044), whereas cholesterol and vitamin B12 intakes were significantly lower (both P&lt;=0 013).	Zinc	144-146	NUT midline carcinoma family member 1	Homo sapiens	57-60
26627720-7	2016	Consistent with a role of the K(+) current in amplifying the sensory response, entry of protons through the Zn(2+)-sensitive conductance produces a transient block of the KIR2.1 current.	Zinc	108-114	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	171-177
19754813-5	2006	Sequence differences between individuals in p53 and SIRT2 were found in two cell lines including a stop codon in p53 and substitutions of conserved cysteine residues in the Zn(2+)-binding motif in SIRT2.	Zinc	173-175	tumor protein p53	Canis lupus familiaris	44-47
16818790-8	2006	We found that Zn was required for FcepsilonRI-induced translocation of granules to the plasma membrane, a process that we have shown to be important for MC degranulation.	Zinc	14-16	Fc epsilon receptor Ia	Homo sapiens	34-45
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	212-218	neurotrophic receptor tyrosine kinase 1	Homo sapiens	54-57
16818790-10	2006	These results revealed that Zn was involved in multiple steps of FcepsilonRI-induced MC activation and required for degranulation and cytokine production.	Zinc	28-30	Fc epsilon receptor Ia	Homo sapiens	65-76
26574547-9	2016	The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2.	Zinc	121-127	protein tyrosine phosphatase non-receptor type 5	Homo sapiens	72-78
29668173-8	2016	The mean Zn level and Zn/Cu ratio was significantly lower in CP patients with diabetes and those with low elastase1 as compared to non-diabetics and those with normal elastase1 respectively.	Zinc	9-11	chymotrypsin like elastase 1	Homo sapiens	106-115
16633561-4	2006	Both AtCAD5 and AtCAD4 are dimers with two zinc ions per subunit and belong to the Zn-dependent medium chain dehydrogenase/reductase (MDR) superfamily, on the basis of their overall 2-domain structures and distribution of secondary structural elements.	Zinc	83-85	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	16-22
26637978-5	2015	SLC39A8 is a member of the solute carrier gene family known to import Mn, Zn, and other divalent cations across the plasma membrane.	Zinc	74-76	solute carrier family 39 member 8	Homo sapiens	0-7
16460681-5	2006	This supershift was observed for HSF1/HSE complexes induced by Zn, Cd, Ag, and heat shock.	Zinc	63-65	heat shock transcription factor 1	Homo sapiens	33-37
26637978-7	2015	Our findings identify a human Mn and Zn transporter deficiency syndrome linked to SLC39A8, providing insight into the roles of Mn and Zn homeostasis in human health and development.	Zinc	37-39	solute carrier family 39 member 8	Homo sapiens	82-89
16460681-5	2006	This supershift was observed for HSF1/HSE complexes induced by Zn, Cd, Ag, and heat shock.	Zinc	63-65	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	38-41
26375174-6	2015	Similarly, Zn(2+)-dependent extracellular-regulated kinase 1/2 phosphorylation and up-regulation of NHE activity were absent at acidic pHe.	Zinc	11-17	solute carrier family 9 member C1	Homo sapiens	100-103
16423564-2	2006	We now show that NO donors also affected the activity of the metal responsive transcription factor MTF-1 that translocates from the cytosol to the nucleus in response to physiologically relevant increases in intracellular Zn and transactivates MT gene expression.	Zinc	222-224	metal regulatory transcription factor 1	Homo sapiens	99-104
16519301-1	2006	Quantitative real-time polymerase chain reaction (PCR) was used to compare for the first time the differential expression of metallothionein (MT) isoform genes, together with biosynthesis of the total MT proteins, in the gills of triploid and diploid juvenile Pacific oyster Crassostrea gigas in response to cadmium (Cd) and zinc (Zn) exposure.	Zinc	331-333	LOC105323466	Crassostrea gigas	125-140
26462412-3	2015	Two sensors in particular demonstrate optimized parameters and, therefore, show exceptionally high longitudinal relaxivities of about 50 mM(-1) s(-1) upon binding to Zn(II) and human serum albumin (HSA).	Zinc	166-168	albumin	Mus musculus	183-196
16519301-1	2006	Quantitative real-time polymerase chain reaction (PCR) was used to compare for the first time the differential expression of metallothionein (MT) isoform genes, together with biosynthesis of the total MT proteins, in the gills of triploid and diploid juvenile Pacific oyster Crassostrea gigas in response to cadmium (Cd) and zinc (Zn) exposure.	Zinc	331-333	LOC105323466	Crassostrea gigas	142-144
26451804-2	2015	Here we report a novel strategy to synthesize Zn x Cd1-x S NFs via the synergistic actions of the graphene oxide (GO) confinement effect and oriented cation exchange.	Zinc	46-48	CD1c molecule	Homo sapiens	51-54
26395757-5	2015	Meanwhile, two different zincs inhibited the ZEA-induced loss of mitochondrial membrane potential and elevation of late-stage apoptosis via activating the mitochondrial apoptotic pathway by recovering the mRNA and protein expression of pro-apoptotic genes (Bax, Casp3, Casp9).	Zinc	25-30	caspase 9	Mus musculus	269-274
26288315-3	2015	Remarkably, the obtained 4H/fcc-Au@Ag2S NRBs can be further converted to a novel class of 4H/fcc-Au@metal sulfide core-shell NRB heterostructures, referred to as 4H/fcc-Au@MS (M = Cd, Pb or Zn), through the cation exchange.	Zinc	190-192	angiotensin II receptor type 1	Homo sapiens	35-39
16386795-1	2006	The synthesis, characterization and biological activity of the first zinc(II) complexes with potent inhibitors of cyclin-dependent kinases (CDKs) derived from 6-benzylaminopurine are described.	Zinc	69-77	cyclin dependent kinase 2	Homo sapiens	140-144
16288781-2	2005	Zn(2+) binding by the engineered MBP was thought to require a large conformational change from "open" to "closed", similar to that observed when maltose is bound by the wild-type protein.	Zinc	0-6	myelin basic protein	Homo sapiens	33-36
16288781-3	2005	We show that although this re-designed MBP molecule binds Zn(2+) with high affinity as previously reported, it does not adopt a closed conformation in solution as assessed by small-angle X-ray scattering.	Zinc	58-60	myelin basic protein	Homo sapiens	39-42
16288781-4	2005	High-resolution crystallographic studies of the engineered Zn(2+)-binding MBP molecule demonstrate that Zn(2+) is coordinated by residues on the N-terminal lobe only, and therefore Zn(2+) binding does not require the protein to adopt a fully closed conformation.	Zinc	59-61	myelin basic protein	Homo sapiens	74-77
16288781-4	2005	High-resolution crystallographic studies of the engineered Zn(2+)-binding MBP molecule demonstrate that Zn(2+) is coordinated by residues on the N-terminal lobe only, and therefore Zn(2+) binding does not require the protein to adopt a fully closed conformation.	Zinc	104-106	myelin basic protein	Homo sapiens	74-77
16288781-4	2005	High-resolution crystallographic studies of the engineered Zn(2+)-binding MBP molecule demonstrate that Zn(2+) is coordinated by residues on the N-terminal lobe only, and therefore Zn(2+) binding does not require the protein to adopt a fully closed conformation.	Zinc	104-106	myelin basic protein	Homo sapiens	74-77
16215279-5	2005	Circumstance data have indicated that the GluR2 subunits dictate Ca2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons.	Zinc	70-74	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	42-47
17162855-1	2005	PURPOSE: To investigate whether the induction of heat shock protein (HSP)72 by heat stress (HS) or zinc (Zn2+ ) administration can increase survival of retinal ganglion cells (RGC)in rat model of acute experimental glaucoma.	Zinc	105-109	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	69-75
15861476-6	2005	Whereas Mg2+, Mn2+, and Cd2+ only bind to the more basic 5"-terminal phosphate group, Pb2+, and to a certain extent also Zn2+, show a remarkably enhanced stability of the [M(pUpU)]- complex.	Zinc	121-125	mucin 7, secreted	Homo sapiens	8-11
25670850-12	2015	Additionally, Zn(ASA)2 significantly increased the mRNA-expression of superoxide dismutase 1 (+73 +- 15%), glutathione peroxidase 4 (+44 +- 12%), and transforming growth factor (TGF)-beta1 (+102 +- 22%).	Zinc	14-16	glutathione peroxidase 4	Rattus norvegicus	107-131
26112153-8	2015	Because the hydrophobic cavity of CA around the active center pre-organized the orientation of SA, thereby fixing the ligating NH(-) moiety to the apex of the tetrahedron supported by three basal His3 of CA, metals such as Zn and Co at the center of M-CA gave the most stable CA-SA complex.	Zinc	223-225	carbonic anhydrase 2	Bos taurus	34-36
15953358-3	2005	Zn induced a complex biphasic effect of inhibition and enhancement of [(3)H]LY354740 binding to mGlu3.	Zinc	0-2	glutamate receptor, metabotropic 3	Mus musculus	96-101
15953358-4	2005	Observations with a series of chimeric mGlu2/3 receptors suggest that the Zn effect resides in the N-terminal domain of mGlu2 and mGlu3.	Zinc	74-76	glutamate receptor, metabotropic 3	Mus musculus	39-46
15953358-4	2005	Observations with a series of chimeric mGlu2/3 receptors suggest that the Zn effect resides in the N-terminal domain of mGlu2 and mGlu3.	Zinc	74-76	glutamate receptor, metabotropic 3	Mus musculus	130-135
15953358-5	2005	We observed that the His56 of mGlu2, which corresponds to Asp63 in mGlu3 was largely accountable for the second phase of the Zn effect.	Zinc	125-127	glutamate receptor, metabotropic 3	Mus musculus	67-72
26112153-10	2015	Thus, pre-organization of SA was the key to facilitating the tetrahedral coordination geometry of the Zn(II) active center of CA.	Zinc	102-108	carbonic anhydrase 2	Bos taurus	126-128
25977654-0	2015	Facile synthesis of composition-tuned ZnO/Zn x Cd1-x Se nanowires for photovoltaic applications.	Zinc	38-40	CD1c molecule	Homo sapiens	47-50
15713785-7	2005	Expressed SLC41A1 transports a range of other divalent cations: Mg2+, Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, and Cd2+.	Zinc	76-80	solute carrier family 41, member 1	Mus musculus	10-17
15847434-2	2005	The coordination properties of L3 and of two analogous macrocyclic ligands (L1 and L2) toward Cu(II) and Zn(II) metal ions are reported.	Zinc	105-111	HEXIM P-TEFb complex subunit 2	Homo sapiens	31-33
25023609-0	2015	Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).	Zinc	104-106	E1A binding protein p300	Homo sapiens	28-32
25023609-4	2015	Both the naphthoquinones and ninhydrin were observed to induce Zn(II) ejection from p300 and the catalytic domain of the histone demethylase KDM4A.	Zinc	63-69	E1A binding protein p300	Homo sapiens	84-88
25722997-1	2015	A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized.	Zinc	54-56	lysine acetyltransferase 8	Homo sapiens	20-23
15634741-3	2005	In the present study, we have used a unique mammary epithelial cell model (HC11) to characterize the role of Zip3 in mammary epithelial cell Zn(2+) transport.	Zinc	141-143	solute carrier family 39 member 3	Homo sapiens	109-113
15634741-5	2005	Total (65)Zn transport was higher in secreting cells, while gene silencing of Zip3 decreased (65)Zn uptake into mammary epithelial cells, particularly in those with a secretory phenotype.	Zinc	97-99	solute carrier family 39 member 3	Homo sapiens	78-82
15634741-6	2005	Finally, reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import, which may reflect the unique requirement for Zn(2+) of this highly specialized cell type and thus provides a physiological explanation for the restricted tissue distribution of this Zn(2+) importer.	Zinc	156-158	solute carrier family 39 member 3	Homo sapiens	31-35
15634741-6	2005	Finally, reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import, which may reflect the unique requirement for Zn(2+) of this highly specialized cell type and thus provides a physiological explanation for the restricted tissue distribution of this Zn(2+) importer.	Zinc	156-158	solute carrier family 39 member 3	Homo sapiens	142-146
15634741-6	2005	Finally, reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import, which may reflect the unique requirement for Zn(2+) of this highly specialized cell type and thus provides a physiological explanation for the restricted tissue distribution of this Zn(2+) importer.	Zinc	216-218	solute carrier family 39 member 3	Homo sapiens	31-35
25722997-1	2015	A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized.	Zinc	54-56	lysine acetyltransferase 8	Homo sapiens	30-33
25541535-7	2015	Notably, maternal dietary organic Zn exposure exhibited greater attenuation of gut impairment, along with increased MUC2 expression and sIgA level, and decreased the abundance of TNF-alpha and A20 relative to the inorganic-Zn group.	Zinc	34-36	lipopolysaccharide induced TNF factor	Gallus gallus	179-188
24833283-4	2015	The band gap of Znx Cd1-x S/alginate core/shell nanoparticles increases with increasing Zn/Cd molar ratio, and the UV/vis absorption blue-shifts correspondingly.	Zinc	16-18	CD1c molecule	Homo sapiens	20-23
15817131-1	2005	BACKGROUND: Energy and Zinc (Zn) deficiencies have been associated with nutritional related growth retardation as well as growth hormone (GH) resistance.	Zinc	29-31	gonadotropin releasing hormone receptor	Rattus norvegicus	122-136
15817131-6	2005	Growth hormone treated rats fed only suboptimal Zn (100/70), had increased weight gain (217.5 +/- 13.2 vs. 191.6 +/- 17.9 g; p &lt; 0.05) compared to those given NSS.	Zinc	48-50	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
24833283-6	2015	A cadmium-related emission was observed for both the uncovered Znx Cd1-x S and Znx Cd1-x S/alginate core/shell nanoparticles, which has a significant blue-shift with increasing Zn/Cd molar ratio.	Zinc	63-65	CD1c molecule	Homo sapiens	67-70
25446125-1	2015	The voltage-gated proton channel Hv1 is strongly sensitive to Zn(2+).	Zinc	62-64	hydrogen voltage gated channel 1	Homo sapiens	33-36
15781326-2	2005	The majority of MMP-2 inhibitor candidate drugs block the active site of MMP-2 by binding to its catalytic Zn2+ ion through a chelating (hydroxamate, sulphonate etc.)	Zinc	107-111	matrix metallopeptidase 2	Homo sapiens	16-21
15781326-2	2005	The majority of MMP-2 inhibitor candidate drugs block the active site of MMP-2 by binding to its catalytic Zn2+ ion through a chelating (hydroxamate, sulphonate etc.)	Zinc	107-111	matrix metallopeptidase 2	Homo sapiens	73-78
25446125-2	2015	The H(+) conduction is decreased at a high concentration of Zn(2+) and Hv1 channel closing is slowed by the internal application of Zn(2+).	Zinc	132-134	hydrogen voltage gated channel 1	Homo sapiens	71-74
25446125-4	2015	Here, we studied the pH-dependent structural stability of the intracellular C-terminal domain of human Hv1 and showed that Zn(2+) binds to His(244) and His(266) residues.	Zinc	123-125	hydrogen voltage gated channel 1	Homo sapiens	103-106
15747135-3	2005	We have studied the Co(II)- and Zn(II)-binding of a series of derivatives of L36, a small zinc ribbon protein containing a (Cys)(3)His metal coordination site.	Zinc	32-38	ribosomal protein L36	Homo sapiens	77-80
25832641-2	2015	MTF-1 is known to be activated by heavy metals such as Zn and Cd, but the mechanism of activation remains unclear.	Zinc	55-57	metal regulatory transcription factor 1	Homo sapiens	0-5
15747135-7	2005	L36, displaying Co(II)- and Zn(II)-binding sensitivity to various sequence mutations without undergoing a change in protein structure, can therefore serve as a useful model system for future structure/reactivity studies.	Zinc	28-34	ribosomal protein L36	Homo sapiens	0-3
25832641-3	2015	In the present study, Cys and His residues of human MTF-1 (hMTF-1), some of which may be involved in interaction with metals or with each other, were screened for their contribution to Zn-dependent transcription.	Zinc	185-187	metal regulatory transcription factor 1	Homo sapiens	52-57
15733866-4	2005	AtHMA4 expression resulted in an increased tolerance to Zn, Cd and Pb and to a phenotypic complementation of hypersensitive mutants.	Zinc	56-58	heavy metal atpase 4	Arabidopsis thaliana	0-6
25832641-3	2015	In the present study, Cys and His residues of human MTF-1 (hMTF-1), some of which may be involved in interaction with metals or with each other, were screened for their contribution to Zn-dependent transcription.	Zinc	185-187	metal regulatory transcription factor 1	Homo sapiens	59-65
25832641-8	2015	These results indicate that Zn activation of hMTF-1 involves an additional process besides induction of DNA binding activity.	Zinc	28-30	metal regulatory transcription factor 1	Homo sapiens	45-51
15697212-3	2005	The Hx-heme complex exhibited similar behavior except the order of retention of the complex on Zn(2+)- and Co(2+)-charged columns was reversed.	Zinc	95-101	hemopexin	Homo sapiens	4-6
25266449-5	2015	Integral to this reprogramming are "switching" pathways in transcriptional networks, other than the well-characterized effects of NFkappaB and mitogen-activated protein kinase signalling; HIF-2alpha transcriptional signalling and ZIP8-mediated Zn(2+) uptake, with downstream MTF1 transcriptional signalling, have been implicated but further validation is required.	Zinc	244-250	solute carrier family 39 member 8	Homo sapiens	230-234
15697212-8	2005	Binding of Cu(2+) and Zn(2+) to the Hx-heme complex produced significant changes in the Soret-CD spectrum of the Hx-heme complex that were reversed with addition of EDTA.	Zinc	22-24	hemopexin	Homo sapiens	36-38
25506946-5	2014	The biophysical properties and the responses to PcTx1, amiloride, Ca2+ and Zn2+ suggested that ASIC currents were mediated predominantly by heteromultimeric channels that contained ASIC1a and ASIC2a or ASIC2b.	Zinc	75-79	acid-sensing (proton-gated) ion channel 1	Mus musculus	95-99
15667214-2	2005	In the cyanide-bridged, spin-coupled heme-copper center in an engineered myoglobin, the presence of Zn(II) in the Cu(B) center raises the heme reduction potential from -85 to 49 mV vs NHE.	Zinc	100-106	solute carrier family 9 member C1	Homo sapiens	184-187
25325734-6	2014	As expected, our study demonstrates that unlike the parent DMOF structures (based on Co, Ni, Cu, and Zn metals), which all collapse under 60% relative humidity (RH), their corresponding tetramethyl-functionalized variations (DMOF-TM) are remarkably stable, even when adsorbing more than 20 mmol of H2O/g of MOF at 80% RH.	Zinc	101-103	lysine acetyltransferase 8	Homo sapiens	60-63
15670822-6	2005	The possible role of Zn2+ ions and the participation of acidic amino acids Glu and Asp in adenosine deamination catalyzed by ADA2 were shown.	Zinc	21-25	adenosine deaminase 2	Homo sapiens	125-129
15670847-0	2005	The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels.	Zinc	44-46	heavy metal atpase 4	Arabidopsis thaliana	26-32
15670847-2	2005	Arabidopsis thaliana HMA4, belonging to the Type P1B subfamily of P-type ATPases, has recently been implicated in Zn nutrition, having a role in root to shoot Zn translocation.	Zinc	114-116	heavy metal atpase 4	Arabidopsis thaliana	21-25
15670847-2	2005	Arabidopsis thaliana HMA4, belonging to the Type P1B subfamily of P-type ATPases, has recently been implicated in Zn nutrition, having a role in root to shoot Zn translocation.	Zinc	159-161	heavy metal atpase 4	Arabidopsis thaliana	21-25
15670847-3	2005	Using Arabidopsis insertional mutants, it is shown here that disruption of AtHMA4 function also results in increased sensitivity to elevated levels of Cd and Zn, suggesting that AtHMA4 serves an important role in metal detoxification at higher metal concentrations.	Zinc	158-160	heavy metal atpase 4	Arabidopsis thaliana	75-81
25183670-4	2014	The sensitivity of Cav3.2 channels to H2S required the presence of the redox-sensitive extracellular residue H191, which is also required for tonic binding of Zn(2+) to this channel.	Zinc	159-161	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	19-25
15670847-3	2005	Using Arabidopsis insertional mutants, it is shown here that disruption of AtHMA4 function also results in increased sensitivity to elevated levels of Cd and Zn, suggesting that AtHMA4 serves an important role in metal detoxification at higher metal concentrations.	Zinc	158-160	heavy metal atpase 4	Arabidopsis thaliana	178-184
15670847-4	2005	AtHMA4 and a truncated form lacking the last 457 amino acids both confer Cd and Zn resistance to yeast but a mutant version of the full-length AtHMA4 (AtHMA4-C357G) does not; this demonstrates that the C-terminal region is not essential for this function.	Zinc	80-82	heavy metal atpase 4	Arabidopsis thaliana	0-6
15641773-4	2005	(2003) Biochemistry 42, 9937] suggested that the isolated p300 TAZ1 domain lacks a well-defined structure and behaves like a molten globule, even in the presence of Zn(2+), and that the formation of a stable three-dimensional structure requires binding of a protein partner.	Zinc	165-167	E1A binding protein p300	Homo sapiens	58-62
15641773-5	2005	In marked contrast to this result, we find that both the CBP and p300 TAZ domains in the presence of stoichiometric concentrations of Zn(2+) adopt a well-defined structure in solution in the absence of binding partners.	Zinc	134-136	E1A binding protein p300	Homo sapiens	65-69
25192149-8	2014	Previously it was proposed that the catalytic mechanism of DPP III is similar to that of thermolysin, which assumes exchange of five and four coordinated Zn(2+), and activation of Zn-bound water by a nearby Glu.	Zinc	154-156	dipeptidyl peptidase 3	Homo sapiens	59-66
16327072-3	2005	We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study.	Zinc	52-54	gonadotropin releasing hormone receptor	Rattus norvegicus	79-93
16327072-3	2005	We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study.	Zinc	52-54	gonadotropin releasing hormone receptor	Rattus norvegicus	95-97
25192149-8	2014	Previously it was proposed that the catalytic mechanism of DPP III is similar to that of thermolysin, which assumes exchange of five and four coordinated Zn(2+), and activation of Zn-bound water by a nearby Glu.	Zinc	180-182	dipeptidyl peptidase 3	Homo sapiens	59-66
25325899-4	2014	Herein, nano fluorine-doped hydroxyapatite (FAp, a well-known biocompatible material) was introduced to endow biocompatibility to Cd-free Mn-doped ZnSe@ZnS QDs.	Zinc	147-150	fibroblast activation protein alpha	Homo sapiens	44-47
15632449-7	2005	The Mramp-KO phagosome showed a significant increase of P, Ca, Mn, Fe and Zn concentrations between 1 and 24 h after infection, while the concentrations of K and Ni decreased.	Zinc	74-76	divalent metal cation transporter MntH	Mycobacterium tuberculosis H37Rv	4-9
25272315-6	2014	Overexpression of AtHMA4 had a large impact on Zn and Cd translocation and resulted in a 3-fold higher potential of Cd and Zn extraction from an industrial soil highly contaminated by Zn, Pb and Cd.	Zinc	47-49	heavy metal atpase 4	Arabidopsis thaliana	18-24
15485870-3	2004	Recently we have shown that mutants of Kv4.2 lacking the ability to bind an intersubunit Zn(2+) between their T1 domains fail to form functional channels because they are unable to assemble to tetramers and remain trapped in the endoplasmic reticulum.	Zinc	89-91	potassium voltage-gated channel subfamily D member 2	Homo sapiens	39-44
25272315-6	2014	Overexpression of AtHMA4 had a large impact on Zn and Cd translocation and resulted in a 3-fold higher potential of Cd and Zn extraction from an industrial soil highly contaminated by Zn, Pb and Cd.	Zinc	123-125	heavy metal atpase 4	Arabidopsis thaliana	18-24
25272315-6	2014	Overexpression of AtHMA4 had a large impact on Zn and Cd translocation and resulted in a 3-fold higher potential of Cd and Zn extraction from an industrial soil highly contaminated by Zn, Pb and Cd.	Zinc	123-125	heavy metal atpase 4	Arabidopsis thaliana	18-24
15525775-1	2004	Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons.	Zinc	66-70	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	98-118
25272315-7	2014	Despite AtHMA4 overexpressing lines presenting a higher Zn concentration in the shoot, the Zn content in the seeds was found to be lower than in wild type plants.	Zinc	56-58	heavy metal atpase 4	Arabidopsis thaliana	8-14
15525775-1	2004	Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons.	Zinc	66-70	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	120-125
25272315-8	2014	Our results indicate that AtHMA4 overexpression is an efficient tool to increase the root to shoot translocation of Zn and Cd in plants.	Zinc	116-118	heavy metal atpase 4	Arabidopsis thaliana	26-32
15525775-1	2004	Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons.	Zinc	66-70	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	151-157
24881047-1	2014	d-Serine dehydratase from Saccharomyces cerevisiae (Dsd1p) is a pyridoxal 5"-phosphate (PLP)- and Zn(2+)-dependent enzyme that catalyzes the dehydration of d-serine to yield pyruvate and ammonia.	Zinc	98-104	D-serine ammonia-lyase DSD1	Saccharomyces cerevisiae S288C	52-57
15525775-5	2004	Early CaEDTA attenuated ischemia-induced GluR2 mRNA and protein downregulation (and, by inference, formation of Zn2+-permeable AMPARs), the delayed rise in Zn2+, and neuronal death.	Zinc	112-116	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	127-133
15525775-6	2004	These findings suggest that Zn2+ acts at step(s) upstream from GluR2 gene downregulation and implicate Zn2+ in transcriptional regulation and/or GluR2 mRNA stability.	Zinc	28-32	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	63-68
25162517-0	2014	Zn-responsive proteome profiling and time-dependent expression of proteins regulated by MTF-1 in A549 cells.	Zinc	0-2	metal regulatory transcription factor 1	Homo sapiens	88-93
25162517-4	2014	In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1.	Zinc	147-149	metal regulatory transcription factor 1	Homo sapiens	126-131
15498553-1	2004	AtHMA4 is an Arabidopsis thaliana P1B-ATPase which transports Zn and Cd.	Zinc	62-64	heavy metal atpase 4	Arabidopsis thaliana	0-6
15498553-3	2004	The ectopic overexpression of AtHMA4 improved the root growth in the presence of toxic concentrations of Zn, Cd and Co. A null mutant exhibited a lower translocation of Zn and Cd from the roots to shoot.	Zinc	105-107	heavy metal atpase 4	Arabidopsis thaliana	30-36
25105504-5	2014	Zn2+ supplementation alleviated Cd2+-induced cytotoxicity and this protective effect was more obvious when cells were exposed to a lower concentration of Cd2+ (10 muM), as compared to 50 muM Cd2+.	Zinc	0-4	CD2 molecule	Bos taurus	154-157
15498553-3	2004	The ectopic overexpression of AtHMA4 improved the root growth in the presence of toxic concentrations of Zn, Cd and Co. A null mutant exhibited a lower translocation of Zn and Cd from the roots to shoot.	Zinc	169-171	heavy metal atpase 4	Arabidopsis thaliana	30-36
25105504-5	2014	Zn2+ supplementation alleviated Cd2+-induced cytotoxicity and this protective effect was more obvious when cells were exposed to a lower concentration of Cd2+ (10 muM), as compared to 50 muM Cd2+.	Zinc	0-4	CD2 molecule	Bos taurus	154-157
25105504-9	2014	Notably, addition of Zn2+ reduced the amounts of cytosolic Cd2+ detected following MDBK exposure to 10 muM Cd2+.	Zinc	21-25	CD2 molecule	Bos taurus	59-62
25105504-9	2014	Notably, addition of Zn2+ reduced the amounts of cytosolic Cd2+ detected following MDBK exposure to 10 muM Cd2+.	Zinc	21-25	CD2 molecule	Bos taurus	107-110
25105504-10	2014	These findings revealed a protective role of Zn2+ in counteracting Cd2+ uptake and toxicity in MDBK cells, indicating that this approach may provide a means to protect livestock from excessive Cd2+ accumulation.	Zinc	45-49	CD2 molecule	Bos taurus	67-70
25105504-10	2014	These findings revealed a protective role of Zn2+ in counteracting Cd2+ uptake and toxicity in MDBK cells, indicating that this approach may provide a means to protect livestock from excessive Cd2+ accumulation.	Zinc	45-49	CD2 molecule	Bos taurus	193-196
24829149-8	2014	Additionally, the inhibition of lysosomal exocytosis through knockdown (KD) of the lysosomal SNARE proteins VAMP7 and synaptotagmin VII (SYT7) suppressed Zn(2+) secretion and VAMP7 KD cells had increased apoptosis.	Zinc	154-156	synaptotagmin 7	Homo sapiens	118-135
24829149-8	2014	Additionally, the inhibition of lysosomal exocytosis through knockdown (KD) of the lysosomal SNARE proteins VAMP7 and synaptotagmin VII (SYT7) suppressed Zn(2+) secretion and VAMP7 KD cells had increased apoptosis.	Zinc	154-156	synaptotagmin 7	Homo sapiens	137-141
24264723-11	2014	Finally, we show that in PC3 cells ZnR/GPR39 is required for mediating the Zn(2+) -dependent activation of MAPK and PI3K, pathways leading to enhanced cell growth.	Zinc	75-81	keratin 6A	Homo sapiens	25-28
24092018-8	2014	QDs themselves are likely to contribute to HSP70B" promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.	Zinc	112-115	heat shock protein family A (Hsp70) member 7 (pseudogene)	Homo sapiens	43-49
24576911-2	2014	Zinc transporters such as Zrt, Irt-related protein 8 (ZIP8), and ZIP14 have been shown to have affinities for Mn(2+) as well as Zn(2+), but their roles in Mn(2+) uptake in neuronal cells remain unclear.	Zinc	128-130	solute carrier family 39 member 8	Homo sapiens	54-58
24576911-2	2014	Zinc transporters such as Zrt, Irt-related protein 8 (ZIP8), and ZIP14 have been shown to have affinities for Mn(2+) as well as Zn(2+), but their roles in Mn(2+) uptake in neuronal cells remain unclear.	Zinc	128-130	solute carrier family 39 member 14	Homo sapiens	65-70
24497284-5	2014	RESULTS: Mass spectra of CsA obtained upon post-column addition of solutions of Ca(II), Cu(II) and Zn(II) showed complexes between cyclosporin and the metal, including [2CsA + Me](2+) and [CsA-H + Me](+).	Zinc	99-105	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	25-28
15381762-9	2004	In Zn-adequate mice, ZnT1 is diffusely distributed in acinar cell cytoplasm and colocalizes with alpha-amylase but is not detected in pancreatic islets.	Zinc	3-5	solute carrier family 30 (zinc transporter), member 1	Mus musculus	21-25
15381762-10	2004	In acinar cells during Zn depletion, ZnT1 is localized to the plasma membrane.	Zinc	23-25	solute carrier family 30 (zinc transporter), member 1	Mus musculus	37-41
15470133-4	2004	Here we show that the divalent cation Zn2+, an endogenous trace element, dose-dependently inhibits ASIC currents in cultured mouse cortical neurons at nanomolar concentrations.	Zinc	38-42	acid-sensing (proton-gated) ion channel 1	Mus musculus	99-103
15470133-5	2004	With ASICs expressed in Chinese hamster ovary cells, Zn2+ inhibits currents mediated by homomeric ASIC1a and heteromeric ASIC1a-ASIC2a channels, without affecting currents mediated by homomeric ASIC1beta, ASIC2a, or ASIC3.	Zinc	53-57	acid-sensing (proton-gated) ion channel 1	Mus musculus	98-104
15470133-5	2004	With ASICs expressed in Chinese hamster ovary cells, Zn2+ inhibits currents mediated by homomeric ASIC1a and heteromeric ASIC1a-ASIC2a channels, without affecting currents mediated by homomeric ASIC1beta, ASIC2a, or ASIC3.	Zinc	53-57	acid-sensing (proton-gated) ion channel 1	Mus musculus	121-127
15470133-5	2004	With ASICs expressed in Chinese hamster ovary cells, Zn2+ inhibits currents mediated by homomeric ASIC1a and heteromeric ASIC1a-ASIC2a channels, without affecting currents mediated by homomeric ASIC1beta, ASIC2a, or ASIC3.	Zinc	53-57	acid-sensing ion channel 3	Cricetulus griseus	216-221
15470133-6	2004	Consistent with ASIC1a-specific modulation, high-affinity Zn2+ inhibition is absent in neurons from ASIC1a knock-out mice.	Zinc	58-62	acid-sensing (proton-gated) ion channel 1	Mus musculus	100-106
15470133-8	2004	Mutation of lysine-133 in the extracellular domain of the ASIC1a subunit abolishes the high-affinity Zn2+ inhibition.	Zinc	101-105	acid-sensing (proton-gated) ion channel 1	Mus musculus	58-64
15470133-9	2004	Our studies suggest that Zn2+ may play an important role in a negative feedback system for preventing overexcitation of neurons during normal synaptic transmission and ASIC1a-mediated excitotoxicity in pathological conditions.	Zinc	25-29	acid-sensing (proton-gated) ion channel 1	Mus musculus	168-174
15322227-6	2004	Preincubation of cortical cultures with IGF-I increased arachidonic acid (AA)-induced cytotoxicity, and AA increased Zn(2+) toxicity, which suggested the involvement of COX activity in these cellular responses.	Zinc	117-123	cytochrome c oxidase subunit 8A	Homo sapiens	169-172
15262058-2	2004	Excessive intracellular Zn(2+) in many cell types triggers the expression of genes that encode metal binding proteins, such as metallothionein, via the activation and nuclear translocation of metal response element (MRE)-binding transcription factor-1 (MTF-1).	Zinc	24-26	metal regulatory transcription factor 1	Homo sapiens	192-251
15262058-2	2004	Excessive intracellular Zn(2+) in many cell types triggers the expression of genes that encode metal binding proteins, such as metallothionein, via the activation and nuclear translocation of metal response element (MRE)-binding transcription factor-1 (MTF-1).	Zinc	24-26	metal regulatory transcription factor 1	Homo sapiens	253-258
15142040-10	2004	Partly oxidized Cox17 can bind one Cu+ or Zn2+ ion, whereas fully oxidized Cox17 does not bind metals.	Zinc	42-46	copper metallochaperone COX17	Saccharomyces cerevisiae S288C	16-21
15218066-4	2004	External Zn(2+), at micromolar concentrations, activated SUR1/Kir6.2 but induced a small inhibition of SUR2A/Kir6.2 channels.	Zinc	9-11	ATP binding cassette subfamily C member 8	Homo sapiens	57-61
15218066-5	2004	Cytosolic Zn(2+) dose-dependently stimulated both SUR1/Kir6.2 and SUR2A/Kir6.2 channels, with half-maximal effects at 1.8 and 60 microm, respectively, but it did not affect the Kir6.2 subunit expressed alone.	Zinc	10-16	ATP binding cassette subfamily C member 8	Homo sapiens	50-54
15218066-6	2004	These observations point to an action of both external and internal Zn(2+) on the SUR subunit.	Zinc	68-70	ATP binding cassette subfamily C member 8	Homo sapiens	82-85
15218066-9	2004	Therefore, Zn(2+) is an endogenous K(ATP) channel opener being active on both sides of the membrane, with potentially distinct sites of action located on the SUR subunit.	Zinc	11-17	ATP binding cassette subfamily C member 8	Homo sapiens	158-161
24497284-5	2014	RESULTS: Mass spectra of CsA obtained upon post-column addition of solutions of Ca(II), Cu(II) and Zn(II) showed complexes between cyclosporin and the metal, including [2CsA + Me](2+) and [CsA-H + Me](+).	Zinc	99-105	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	170-173
15187093-5	2004	Mn(2+) and Ni(2+) substituted for Mg(2+) as a cofactor for WRN helicase, whereas Fe(2+) or Cu(2+) (10 microm) profoundly inhibited WRN unwinding in the presence of Mg(2+).Zn(2+) (100 microm) was preferred over Mg(2+) as a metal cofactor for WRN exonuclease activity and acts as a molecular switch, converting WRN from a helicase to an exonuclease.	Zinc	171-177	WRN RecQ like helicase	Homo sapiens	131-134
15187093-5	2004	Mn(2+) and Ni(2+) substituted for Mg(2+) as a cofactor for WRN helicase, whereas Fe(2+) or Cu(2+) (10 microm) profoundly inhibited WRN unwinding in the presence of Mg(2+).Zn(2+) (100 microm) was preferred over Mg(2+) as a metal cofactor for WRN exonuclease activity and acts as a molecular switch, converting WRN from a helicase to an exonuclease.	Zinc	171-177	WRN RecQ like helicase	Homo sapiens	131-134
15187093-5	2004	Mn(2+) and Ni(2+) substituted for Mg(2+) as a cofactor for WRN helicase, whereas Fe(2+) or Cu(2+) (10 microm) profoundly inhibited WRN unwinding in the presence of Mg(2+).Zn(2+) (100 microm) was preferred over Mg(2+) as a metal cofactor for WRN exonuclease activity and acts as a molecular switch, converting WRN from a helicase to an exonuclease.	Zinc	171-177	WRN RecQ like helicase	Homo sapiens	131-134
15187093-6	2004	Zn(2+) strongly stimulated the exonuclease activity of a WRN exonuclease domain fragment, suggesting a Zn(2+) binding site in the WRN exonuclease domain.	Zinc	0-6	WRN RecQ like helicase	Homo sapiens	57-60
24587242-6	2014	Moreover, the activity of intracellular Zn(2+) uptake significantly increased in high glucose-treated cells in comparison to 5.5 mM glucose, and the mRNA expression of zinc transporters, ZIP6 and ZIP10, was upregulated in 25 mM glucose-treated cells.	Zinc	40-46	solute carrier family 39 member 10	Homo sapiens	196-201
24587242-7	2014	The deficiency of ZIP6 or ZIP10 and intracellular Zn(2+) significantly inhibited the high migration activity in 25 mM glucose medium, indicating that Zn(2+) transported via ZIP6 and ZIP10 play an essential role in the promotion of cell motility by high glucose stimulation.	Zinc	50-52	solute carrier family 39 member 10	Homo sapiens	182-187
24587242-7	2014	The deficiency of ZIP6 or ZIP10 and intracellular Zn(2+) significantly inhibited the high migration activity in 25 mM glucose medium, indicating that Zn(2+) transported via ZIP6 and ZIP10 play an essential role in the promotion of cell motility by high glucose stimulation.	Zinc	150-152	solute carrier family 39 member 10	Homo sapiens	26-31
15187093-6	2004	Zn(2+) strongly stimulated the exonuclease activity of a WRN exonuclease domain fragment, suggesting a Zn(2+) binding site in the WRN exonuclease domain.	Zinc	0-6	WRN RecQ like helicase	Homo sapiens	130-133
24587242-7	2014	The deficiency of ZIP6 or ZIP10 and intracellular Zn(2+) significantly inhibited the high migration activity in 25 mM glucose medium, indicating that Zn(2+) transported via ZIP6 and ZIP10 play an essential role in the promotion of cell motility by high glucose stimulation.	Zinc	150-152	solute carrier family 39 member 10	Homo sapiens	182-187
15187093-6	2004	Zn(2+) strongly stimulated the exonuclease activity of a WRN exonuclease domain fragment, suggesting a Zn(2+) binding site in the WRN exonuclease domain.	Zinc	103-109	WRN RecQ like helicase	Homo sapiens	57-60
15187093-6	2004	Zn(2+) strongly stimulated the exonuclease activity of a WRN exonuclease domain fragment, suggesting a Zn(2+) binding site in the WRN exonuclease domain.	Zinc	103-109	WRN RecQ like helicase	Homo sapiens	130-133
23650259-10	2014	It might be possible that environmental factors like nutritional Zn(2+) status or metal ion homeostasis in general intersect with this distinct pathway centered around ProSAP/Shank proteins and the deregulation of any of these two factors may lead to ASDs.	Zinc	65-67	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	175-180
15221484-4	2004	Crystal structures of ACS revealed major differences in protein conformation and in A-cluster composition; for example, a [Fe(4)S(4)] cluster bridged to a binuclear center in which one of the metal binding sites was occupied by Ni, Cu, or Zn.	Zinc	239-241	acyl-CoA synthetase short chain family member 2	Homo sapiens	22-25
24489995-2	2014	Matrix metalloproteinases (MMPs) comprise a family of over two dozen Zn-dependent endopeptidases thought to be primary effectors of extracellular tissue renewal and remodeling processes.	Zinc	69-71	matrix metallopeptidase 2	Homo sapiens	27-31
15075348-7	2004	The cytotoxicity/apoptotic effect of human S100A8/A9 and DTPA was inhibited significantly (P&lt;0.05) by Zn(+2) and Cu(+2), more effectively than by Ca(2+) and Mg(2+).	Zinc	105-107	S100 calcium binding protein A8	Homo sapiens	43-49
24089422-4	2013	Both Zip11 mRNA and ZIP11 protein were shown to be downregulated during dietary zinc restriction (&lt;1 mg Zn/kg) in the murine stomach tissue but were unaffected in the colon.	Zinc	107-109	solute carrier family 39 (metal ion transporter), member 11	Mus musculus	5-10
15014994-9	2004	It did not affect the activities of superoxide dismutase, ascorbate peroxidase or catalase, but improved glutathione reductase activity under Cu and Zn stress.	Zinc	149-151	glutathione-disulfide reductase	Homo sapiens	105-126
15137746-0	2004	Effect of Zn on acetyl coenzyme a synthase: evidence for a conformational change in the alpha subunit during catalysis.	Zinc	10-12	acyl-CoA synthetase short chain family member 2	Homo sapiens	16-42
24089422-4	2013	Both Zip11 mRNA and ZIP11 protein were shown to be downregulated during dietary zinc restriction (&lt;1 mg Zn/kg) in the murine stomach tissue but were unaffected in the colon.	Zinc	107-109	solute carrier family 39 (metal ion transporter), member 11	Mus musculus	20-25
15137746-6	2004	ACS in which Zn replaced Nip was inactive and did not exhibit the so-called NiFeC EPR signal nor the ability to accept a methyl group from the corrinoid-iron-sulfur protein (CoFeSP).	Zinc	13-15	acyl-CoA synthetase short chain family member 2	Homo sapiens	0-3
23970781-5	2013	Depleting Zn(2+) from culture medium using N,N,N",N"-tetrakis(2-pyridylemethyl)ethylenediamine, a high-affinity Zn(2+) chelator, led to a significant reduction of the stimulated wt-GH secretion.	Zinc	10-12	gonadotropin releasing hormone receptor	Rattus norvegicus	181-183
15137746-12	2004	Zn appears to replace Nip when ACS is in an intermediate state (or states) of catalysis but this(these) state(s) must not be present when ACS is reduced in CO alone, or in the presence of CoA, CoFeSP, or reduced methyl viologen.	Zinc	0-2	acyl-CoA synthetase short chain family member 2	Homo sapiens	31-34
23970781-6	2013	Furthermore, externally added Zn(2+) to culture medium increased intracellular free Zn(2+) levels and recovered wt-GH secretion, suggesting its direct dependence on free Zn(2+) levels after forskolin stimulation.	Zinc	30-32	gonadotropin releasing hormone receptor	Rattus norvegicus	115-117
23970781-8	2013	Taken together, our data support the hypothesis that loss of affinity of GH to Zn(2+) as well as altering intracellular free Zn(2+) content may interfere with normal GH dimerization (aggregation) and storage of the mutant variant (alone or with wt-GH), which could possibly explain impaired GH secretion.	Zinc	79-81	gonadotropin releasing hormone receptor	Rattus norvegicus	73-75
15100400-4	2004	Whereas the individual mutants exhibited no apparent phenotype, hma2 hma4 double mutants had a nutritional deficiency phenotype that could be compensated for by increasing the level of Zn, but not Cu or Co, in the growth medium.	Zinc	185-187	heavy metal atpase 4	Arabidopsis thaliana	69-73
23962989-10	2013	Consistent with the possible involvement of Zn released from MT3, raising intracellular Zn levels increased VEGF levels and activated its receptor, Flk-1, in both WT and MT3-KO retinal cells.	Zinc	88-90	kinase insert domain protein receptor	Mus musculus	148-153
15100400-5	2004	Levels of Zn, but not other essential elements, in the shoot tissues of a hma2 hma4 double mutant and, to a lesser extent, of a hma4 single mutant were decreased compared with the wild type.	Zinc	10-12	heavy metal atpase 4	Arabidopsis thaliana	79-83
15100400-6	2004	Together, these observations indicate a primary role for HMA2 and HMA4 in essential Zn homeostasis.	Zinc	84-86	heavy metal atpase 4	Arabidopsis thaliana	66-70
15100400-10	2004	These observations are consistent with a role for HMA2 and HMA4 in Zn translocation.	Zinc	67-69	heavy metal atpase 4	Arabidopsis thaliana	59-63
15069187-1	2004	The Cu- and Zn-containing superoxide dismutase 1 (SOD1) largely obtains Cu in vivo by means of the action of the Cu chaperone CCS.	Zinc	12-14	copper chaperone for superoxide dismutase	Homo sapiens	126-129
23820730-8	2013	Adding a Zn(2+) chelator fully protected SLP76 in mast cell lysates, thereby enabling an efficient affinity-purification of this adapter with its partners.	Zinc	9-11	lymphocyte cytosolic protein 2	Mus musculus	41-46
23965149-2	2013	Metalloprotein anthrax lethal factor (ALF) binds to HNP 1-3 in a Zn2+-dependent manner.	Zinc	65-69	defensin alpha 3	Homo sapiens	52-59
14762707-14	2004	On the other hand, the amino group in carbamoylphosphonic acid2 lowers the stability of the complexes with metals favoring oxygen ligands (Ca, Mg and Fe) and increases the selectivity towards Zn.	Zinc	192-194	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	58-63
23919513-3	2013	The preparation of Ag2Se-catalyzed ZnSe nanowires at 100-210  C is exampled to elucidate the SSS model, which can be extendable to grow other II-VI semiconductor (e.g., CdSe, ZnS, and CdS) nanowires by the catalysis of nanoscale superionic-phase silver or copper(I) chalcogenides (Ag2Se, Ag2S, and Cu2S).	Zinc	35-38	angiotensin II receptor type 1	Homo sapiens	19-23
15117453-3	2004	To study the significance of Zn(2+) in the cysteine-rich domain of the Tat protein particularly released to the extracellular space, we raised the monoclonal antibody (MAb) 5A4, which has an attractive property of recognizing the Zn(2+)-binding Tat(20-41) peptide but not the apo-Tat(20-41) peptide.	Zinc	29-31	tyrosine aminotransferase	Homo sapiens	71-74
15117453-3	2004	To study the significance of Zn(2+) in the cysteine-rich domain of the Tat protein particularly released to the extracellular space, we raised the monoclonal antibody (MAb) 5A4, which has an attractive property of recognizing the Zn(2+)-binding Tat(20-41) peptide but not the apo-Tat(20-41) peptide.	Zinc	29-35	tyrosine aminotransferase	Homo sapiens	71-74
15117453-6	2004	These results suggest that Zn(2+), whose structure is closely associated with not only the trans-activation of HIV-LTR but also the induction of apoptosis, binds to the extracellular native Tat protein.	Zinc	27-29	tyrosine aminotransferase	Homo sapiens	190-193
15117453-7	2004	The Zn(2+)-binding cysteine-rich domain therefore can be a molecular target in the development of an anti-Tat vaccine and agents for the control of extracellular-Tat-protein-mediated pathogenesis leading to the progression of acquired immunodeficiency syndrome.	Zinc	4-10	tyrosine aminotransferase	Homo sapiens	106-109
15117453-7	2004	The Zn(2+)-binding cysteine-rich domain therefore can be a molecular target in the development of an anti-Tat vaccine and agents for the control of extracellular-Tat-protein-mediated pathogenesis leading to the progression of acquired immunodeficiency syndrome.	Zinc	4-10	tyrosine aminotransferase	Homo sapiens	162-165
23812383-8	2013	Furthermore, ryanodine receptor (RyR) S2808 and phospholamban (PLB) S16/T17 were markedly dephosphorylated after perfusing hearts with 50 muM Zn(2+).	Zinc	142-144	ryanodine receptor 2	Rattus norvegicus	33-36
14610091-4	2004	In addition, the mutated proteins respond to induction by Zn(II) or Cd(II) with nuclear translocation and MRE binding activities comparable with wild-type MTF-1.	Zinc	58-64	metal regulatory transcription factor 1	Homo sapiens	155-160
23812383-10	2013	These findings suggest that Zn(2+) suppresses cardiomyocyte systolic function and enhances relaxation function by lowering systolic and diastolic intracellular Ca(2+) concentrations due to a combination of competitive inhibition of Ca(2+) influx through the L-type calcium channel, reduction of SR Ca(2+) load resulting from phospholamban dephosphorylation, and lowered SR Ca(2+) leak via RyR dephosphorylation.	Zinc	28-34	ryanodine receptor 2	Rattus norvegicus	389-392
23918396-3	2013	Here, we show that Ca(2+)-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is required for a cell death-enabling process previously shown to also depend on Zn(2+).	Zinc	186-188	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	50-95
23918396-3	2013	Here, we show that Ca(2+)-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is required for a cell death-enabling process previously shown to also depend on Zn(2+).	Zinc	186-188	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	97-103
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	insulin-like growth factor 1 receptor	Rattus norvegicus	181-187
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	glycogen synthase kinase 3 beta	Rattus norvegicus	192-200
23755195-8	2013	However, application of the Zn(II) complexes noticeably changed the pro-MMP-2/MMP-2 ratio towards a higher amount of maturated MMP-2, when they induced a 4-times higher production of maturated MMP-2 in comparison with the vehicle-treated cells under LPS stimulation.	Zinc	28-34	matrix metallopeptidase 2	Homo sapiens	72-77
23755195-8	2013	However, application of the Zn(II) complexes noticeably changed the pro-MMP-2/MMP-2 ratio towards a higher amount of maturated MMP-2, when they induced a 4-times higher production of maturated MMP-2 in comparison with the vehicle-treated cells under LPS stimulation.	Zinc	28-34	matrix metallopeptidase 2	Homo sapiens	78-83
23755195-8	2013	However, application of the Zn(II) complexes noticeably changed the pro-MMP-2/MMP-2 ratio towards a higher amount of maturated MMP-2, when they induced a 4-times higher production of maturated MMP-2 in comparison with the vehicle-treated cells under LPS stimulation.	Zinc	28-34	matrix metallopeptidase 2	Homo sapiens	78-83
23755195-8	2013	However, application of the Zn(II) complexes noticeably changed the pro-MMP-2/MMP-2 ratio towards a higher amount of maturated MMP-2, when they induced a 4-times higher production of maturated MMP-2 in comparison with the vehicle-treated cells under LPS stimulation.	Zinc	28-34	matrix metallopeptidase 2	Homo sapiens	78-83
23170996-0	2013	Development of Zn-related necrosis in tobacco is enhanced by expressing AtHMA4 and depends on the apoplastic Zn levels.	Zinc	15-17	heavy metal atpase 4	Arabidopsis thaliana	72-78
14744996-5	2004	The results presented here define the beta-Lact/beta-CASP domain of Artemis as the minimal core catalytic domain needed for V(D)J recombination and suggest that Artemis uses one or two Zn(II) ions to exert its catalytic activity, like bacterial class B beta-Lact enzymes hydrolyzing beta-lactam compounds.	Zinc	185-187	cytohesin 1 interacting protein	Homo sapiens	53-57
14765975-1	2004	Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands.	Zinc	6-12	insulin-like growth factor 1	Mus musculus	188-193
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	heavy metal atpase 3	Arabidopsis thaliana	313-319
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	cell growth defect factor-like protein (DUF3353)	Arabidopsis thaliana	358-364
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	nicotianamine synthase 3	Arabidopsis thaliana	397-403
23170996-1	2013	AtHMA4 was previously shown to contribute to the control of Zn root-to-shoot translocation and tolerance to high Zn.	Zinc	60-62	heavy metal atpase 4	Arabidopsis thaliana	0-6
23170996-1	2013	AtHMA4 was previously shown to contribute to the control of Zn root-to-shoot translocation and tolerance to high Zn.	Zinc	113-115	heavy metal atpase 4	Arabidopsis thaliana	0-6
23170996-4	2013	This study provides a better understanding of the development of this Zn-sensitive phenotype and demonstrates that substantial modifications of Zn homeostasis occur due to AtHMA4 expression.	Zinc	70-72	heavy metal atpase 4	Arabidopsis thaliana	172-178
23170996-4	2013	This study provides a better understanding of the development of this Zn-sensitive phenotype and demonstrates that substantial modifications of Zn homeostasis occur due to AtHMA4 expression.	Zinc	144-146	heavy metal atpase 4	Arabidopsis thaliana	172-178
23170996-5	2013	We show that ectopically expressing AtHMA4 in tobacco results in overloading the root and leaf apoplast with Zn.	Zinc	109-111	heavy metal atpase 4	Arabidopsis thaliana	36-42
23170996-6	2013	The tissue and cellular distribution of Zn, monitored using Zinpyr-1, was altered in the AtHMA4-expressing plants compared with wild type.	Zinc	40-42	heavy metal atpase 4	Arabidopsis thaliana	89-95
23170996-7	2013	Increased loading of the leaf apoplast with Zn in AtHMA4 transformants induced necrosis; this appeared at lower levels of Zn supply in the transgenics compared with wild type.	Zinc	44-46	heavy metal atpase 4	Arabidopsis thaliana	50-56
23170996-7	2013	Increased loading of the leaf apoplast with Zn in AtHMA4 transformants induced necrosis; this appeared at lower levels of Zn supply in the transgenics compared with wild type.	Zinc	122-124	heavy metal atpase 4	Arabidopsis thaliana	50-56
23719795-2	2013	In experiments performed in a Zn(2+)-enriched auditory brainstem nucleus--the dorsal cochlear nucleus--we discovered that synaptic Zn(2+) and GPR39, a putative metabotropic Zn(2+)-sensing receptor (mZnR), are necessary for triggering the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG).	Zinc	30-36	G protein-coupled receptor 39	Mus musculus	142-147
23719795-2	2013	In experiments performed in a Zn(2+)-enriched auditory brainstem nucleus--the dorsal cochlear nucleus--we discovered that synaptic Zn(2+) and GPR39, a putative metabotropic Zn(2+)-sensing receptor (mZnR), are necessary for triggering the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG).	Zinc	30-32	G protein-coupled receptor 39	Mus musculus	142-147
23590825-6	2013	Certain members of the ZIP family (ZIP4, ZIP9, and ZIP12) showed significant induction in roots and shoots of the Zn- seedlings.	Zinc	114-116	zinc transporter 12 precursor	Arabidopsis thaliana	51-56
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Zinc	64-66	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Zinc	97-101	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
23646822-4	2013	[Ir(ppy)2(dtbbpy)](PF6) (ppy = 2-phenylpyridine, dtbbpy = 4,4"-di-tert-butyl-2,2"-bipyridine) was found to be the most robust photocatalyst, and the use of ZnCl2 as the Zn(2+) starting material and acetonitrile as the solvent afforded the highest yield of Zn metal product.	Zinc	156-158	sperm associated antigen 17	Homo sapiens	19-22
23353815-1	2013	Upregulation of Zip14 contributes to hepatic zinc (Zn) and non-transferrin-bound iron (Fe) uptake during infection and inflammation.	Zinc	51-53	solute carrier family 39 (zinc transporter), member 14	Mus musculus	16-21
24378464-7	2013	The positive ion complexes of Zn(II) and Cu(II) were both shown to coordinate via the two imidazole nitrogens of His1 and His5 and either the oxygen of the backbone carbonyl of Cys6 or the oxygen of the C-terminal, respectively.	Zinc	30-36	viral integration site 1	Homo sapiens	113-117
23368341-5	2012	The neutral Zn impurity site together with a N vacancy is considered as the carrier-capturing deep impurity level in bulk GaN.	Zinc	12-14	gigaxonin	Homo sapiens	122-125
22932891-7	2012	Conversely, Zn supplementation would decrease the numbers of eosinophils, neutrophils, and monocytes in BALF; suppress eotaxin and MCP-1 protein secretion; and increase lung IFN-gamma mRNA expression.	Zinc	12-14	C-C motif chemokine ligand 11	Rattus norvegicus	119-126
22562713-18	2012	The results suggest that MT can provide effective protection against endogenous Cu and Zn toxicity in FRDA, similar to the neuroprotective sequestration of Fe in holoferritin.	Zinc	87-89	frataxin	Homo sapiens	102-106
23148261-13	2012	Zn(2+) blocks ClC-Ka as well as its Ca(2+)-insensitive mutant, suggesting that Zn(2+) binds to a different site.	Zinc	0-2	chloride voltage-gated channel Ka	Homo sapiens	14-20
23020689-2	2012	Chitosan-stabilized ZnS Q-dots were synthesized in aqueous medium and were observed to have been converted to HgS, Ag(2)S, and PbS Q-dots in the presence of corresponding ions.	Zinc	20-23	angiotensin II receptor type 1	Homo sapiens	115-121
14622981-3	2003	We examined the roles of L-ascorbic acid (AA) and its transporter, sodium-dependent vitamin C transporter (SVCT) 2, in the Zn-induced expression of osteoblastic differentiation markers.	Zinc	123-125	solute carrier family 23 member 2	Homo sapiens	67-114
14622981-5	2003	Western blotting and kinetic assays showed that Zn increased functional SVCT2 protein levels and AA transport.	Zinc	48-50	solute carrier family 23 member 2	Homo sapiens	72-77
14684753-2	2003	The most important degradative system is insulin degrading enzyme which is a highly conserved metalloendopeptidase requiring Zn(++) for its proteolytic action, although protein disulfide isomerase and cathepsin D are also involved in insulin metabolism.	Zinc	125-131	cathepsin D	Homo sapiens	201-212
22922308-0	2012	Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.	Zinc	11-15	PDZ and LIM domain 5	Homo sapiens	28-31
22922308-0	2012	Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.	Zinc	11-15	PDZ and LIM domain 1	Homo sapiens	42-48
14629481-2	2003	Proteins such as gC1qR, cytokeratin-1 and u-PAR have been identified to be responsible for Zn2+-dependent binding of high molecular weight kininogen (HK) to HUVEC.	Zinc	91-95	complement C1q binding protein	Homo sapiens	17-22
22922308-1	2012	An individual LIM domain has approximately 55 amino acids with 8 highly conserved residues responsible for binding of two Zn(2+) into two distinct zinc finger motifs.	Zinc	122-124	PDZ and LIM domain 5	Homo sapiens	14-17
14629481-2	2003	Proteins such as gC1qR, cytokeratin-1 and u-PAR have been identified to be responsible for Zn2+-dependent binding of high molecular weight kininogen (HK) to HUVEC.	Zinc	91-95	keratin 1	Homo sapiens	24-37
22922308-4	2012	The results demonstrate unambiguously very high (femtomolar) affinity of both Zn(2+) to the conserved LIM domain (K(d)(av)=2.5x10(-14) M) and its additional elevation in the C-terminally extended domain construct (K(d)(av)=3.1x10(-15) M).	Zinc	78-80	PDZ and LIM domain 5	Homo sapiens	102-105
23002309-1	2012	Multi-component synthesis 2-amino-3,5-dicarbonitrile-6-thio-pyridines has been developed by using the reaction of aldehydes, malononitrile, and thiophenols in the presence of a Zn (II) or a Cd(II) metal-organic framework (MOF) as the heterogeneous catalyst.	Zinc	177-184	lysine acetyltransferase 8	Homo sapiens	190-226
12972688-7	2003	Zn ions potently inhibited MAO-A activity, but Fe ions did not inhibit either MAO-A or MAO-B activity in monkey brain mitochondria.	Zinc	0-2	monoamine oxidase A	Rattus norvegicus	27-32
12972688-8	2003	These results indicate that the activating action of CaNa2EDTA on MAO-A was the result of the chelating of Zn ions contained in mitochondria by CaNa2EDTA.	Zinc	107-109	monoamine oxidase A	Rattus norvegicus	66-71
12972688-9	2003	These results also indicate the possibility that Zn ions may regulate physiologically the level of serotonin and norepinephrine content in brain by inhibiting a MAO-A activity.	Zinc	49-51	monoamine oxidase A	Rattus norvegicus	161-166
22837466-8	2012	Gelatinase activity was decreased in lungs from torpid animals, indicating inhibition of the Zn(2+)-dependent MMP-2 and MMP-9.	Zinc	93-99	72 kDa type IV collagenase	Mesocricetus auratus	110-115
22710690-3	2012	Significant fluorescence enhancement is observed with MS1 in the presence of Hg(2+); the metal ions Ag(+), Ca(2+), Cd(2+), Co(2+), Cu(2+), Fe(2+), Fe(3+), K(+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+) cause only minor changes in the fluorescence of the system.	Zinc	197-199	MS	Homo sapiens	54-57
22592803-1	2012	The present paper is focused on zinc(ii) treatment effects on prostatic cell lines PC-3 (tumour) and PNT1A (non-tumour).	Zinc	32-40	keratin 6A	Homo sapiens	83-87
12716893-10	2003	MTF1 null cells were prone to apoptosis after exposure to Zn2+ or Cd2+ that was augmented in presence Cr6+, whereas the onset of apoptosis was significantly delayed in cells overexpressing MTF1.	Zinc	58-62	metal regulatory transcription factor 1	Homo sapiens	0-4
12794140-6	2003	KIR phosphorylation was not dependent on ICAM-1-mediated adhesion and was not blocked by inhibition of actin polymerization, but required Zn(2+).	Zinc	138-140	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	0-3
12775422-4	2003	Evidence for Tat acting at a distinct modulatory site on the NR1 subunit of NMDA receptors was provided by findings that 1 microM Zn(2+) abolished Tat-evoked responses in all neurons tested.	Zinc	130-132	tyrosine aminotransferase	Homo sapiens	13-16
12775422-4	2003	Evidence for Tat acting at a distinct modulatory site on the NR1 subunit of NMDA receptors was provided by findings that 1 microM Zn(2+) abolished Tat-evoked responses in all neurons tested.	Zinc	130-132	tyrosine aminotransferase	Homo sapiens	147-150
12775422-5	2003	Thus, Tat appears to excite neurons via direct activation of the NMDA receptor at an allosteric Zn(2+)-sensitive site.	Zinc	96-102	tyrosine aminotransferase	Homo sapiens	6-9
22592803-4	2012	Impedance-based IC(50) for zinc(ii) is 55.5 and 150.8 muM for PC-3 and PNT1A, respectively.	Zinc	27-35	keratin 6A	Homo sapiens	62-66
22592803-7	2012	Two-fold lower intracellular zinc(ii) in the tumour PC-3 cell line was found.	Zinc	29-37	keratin 6A	Homo sapiens	52-56
12910288-3	2003	Sequence (GCC)8 in VLDL receptor gene forms specific complexes with nuclear proteins of HepG2 cells, the formation of these complexes depended on Zn(2+).	Zinc	146-148	guanylate cyclase 2C	Homo sapiens	10-13
22592803-8	2012	After zinc(ii) treatment &gt;2.6-fold increase of intracellular zinc(ii) was observed in non-tumour PNT1A and in tumour PC-3 cells.	Zinc	6-14	keratin 6A	Homo sapiens	120-124
22592803-8	2012	After zinc(ii) treatment &gt;2.6-fold increase of intracellular zinc(ii) was observed in non-tumour PNT1A and in tumour PC-3 cells.	Zinc	64-72	keratin 6A	Homo sapiens	120-124
22592803-9	2012	In PC-3 cells, free and bound zinc(ii) levels were enhanced more markedly as compared to PNT1A.	Zinc	30-38	keratin 6A	Homo sapiens	3-7
22592803-11	2012	PNT1A cells showed a 4.8-fold increase trend (r = 0.94; p = 0.005); PC-3 did show a significant trend at MT1 and MT2 protein levels (r = 0.93; p = 0.02) with nearly ten-fold increase after 100 muM zinc(ii) treatment.	Zinc	197-205	keratin 6A	Homo sapiens	68-72
12705835-3	2003	Previous studies demonstrated that LuxS contains a divalent metal cofactor, which has been proposed to be a Zn(2+) ion.	Zinc	108-110	Lutheran suppressor, X-linked	Homo sapiens	35-39
22345571-8	2012	Zinc (Zn), a known cytoprotectant, prevented Cd-mediated cell toxicity via ZIP8 uptake.	Zinc	6-8	solute carrier family 39 member 8	Homo sapiens	75-79
12705835-4	2003	To gain insight into the catalytic mechanism of this unusual reaction and the function of the metal cofactor, we developed an efficient expression and purification system to produce LuxS enriched in either Fe(2+), Co(2+), or Zn(2+).	Zinc	225-231	Lutheran suppressor, X-linked	Homo sapiens	182-186
12686747-0	2003	Inhibition by Zn(2+) of A-form monoamine oxidase in monkey brain mitochondria.	Zinc	14-16	monoamine oxidase A	Rattus norvegicus	31-48
22345571-11	2012	From this we contend that ZIP8 plays a critical role at the interface between micronutrient (Zn) metabolism and toxic metal exposure (Cd) in the lung microenvironment following cigarette smoke exposure.	Zinc	93-95	solute carrier family 39 member 8	Homo sapiens	26-30
21939673-3	2012	Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.	Zinc	0-2	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	143-146
12604208-2	2003	Our group has recently identified a new gene, the YMR318C open reading frame, which coded for a Zn-containing NADP(H)-dependent alcohol dehydrogenase (ADHVI).	Zinc	96-98	NADP-dependent alcohol dehydrogenase	Saccharomyces cerevisiae S288C	151-156
21939673-3	2012	Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.	Zinc	0-2	betaine--homocysteine S-methyltransferase	Homo sapiens	206-210
22236806-2	2012	CcO includes 13 different protein subunits, 7 species of phospholipids, 7 species of triglycerides, 4 redox-active metal sites (Cu(A), heme a (Fe(a)), Cu(B), heme a(3) (Fe(a3))) and 3 redox-inactive metal sites (Mg(2+), Zn(2+) and Na(+)).	Zinc	220-222	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-3
21702047-7	2012	Our data suggest that Zip5, Zip8, and Zip10 may be key to Zn acquisition from maternal circulation, while multiple Zip proteins reuptake Zn from milk.	Zinc	58-60	solute carrier family 39 (zinc transporter), member 10	Mus musculus	38-43
22282516-6	2012	The typical DNA-binding domain Zn(II)(2)-Cys(6) of Dal81 is unnecessary for its activity and Uga3 acts as a bridge between Dal81 and DNA.	Zinc	31-33	Uga3p	Saccharomyces cerevisiae S288C	93-97
16256471-5	2003	Comparing the peak positions of the new bands, it was found that the new band induced by the injection of Cr3+ was red-shifted with respect to those induced by Cu2+, Zn2+, or the Cd2+ cations.	Zinc	166-170	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	106-109
22317921-3	2012	We show that phosphorylation of evolutionarily conserved residues in endoplasmic reticulum zinc channel ZIP7 is associated with the gated release of Zn(2+) from intracellular stores, leading to activation of tyrosine kinases and the phosphorylation of AKT and extracellular signal-regulated kinases 1 and 2.	Zinc	149-151	solute carrier family 39 member 7	Homo sapiens	104-108
22790819-1	2012	A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized.	Zinc	53-59	homeobox A cluster	Homo sapiens	86-90
12536316-1	2003	Carbonic anhydrase-related protein (CA-RP VIII) lacks a Zn-binding motif which is essential for carbonic anhydrase activity.	Zinc	56-58	carbonic anhydrase 8	Homo sapiens	0-34
12220488-3	2002	X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A.	Zinc	48-50	betaine--homocysteine S-methyltransferase	Homo sapiens	26-30
12220488-3	2002	X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A.	Zinc	70-72	betaine--homocysteine S-methyltransferase	Homo sapiens	26-30
22976316-4	2012	Among the tropolonato-Zn(II) complexes with various coordination modes, di(2-mercaptotropolonato)zinc(II) (ZT2) with the Zn(S(2)O(2)) coordination mode was found to exhibit the highest in vitro insulin-mimetic activity with respect to inhibition of free fatty acid (FFA) release and enhancement of glucose uptake in isolated rat adipocytes treated with adrenaline.	Zinc	22-24	zinc finger protein 125	Mus musculus	107-110
11984815-4	2002	Among them, ZnT-1 has been suggested to play a key role in reducing cellular Zn(2+) toxicity.	Zinc	77-83	solute carrier family 30 (zinc transporter), member 1	Mus musculus	12-17
22497137-3	2012	The results indicated that the properties of Lan/Zn stabilizer was better than Ca/Zn stabilizer and compound lead salt except static stability and dynamic stability.	Zinc	49-51	DiGeorge syndrome critical region gene 2	Homo sapiens	45-48
21871556-11	2011	Zn may inhibit a ZIP8-mediated Cd uptake, whereas the Mn-sensitive component of uptake would be related to other transport processes.	Zinc	0-2	solute carrier family 39 member 8	Homo sapiens	17-21
12023845-5	2002	Both beta2-integrin- and uPAR-dependent processes are activated by Zn2+ and are blocked by high-molecular-mass kininogen.	Zinc	67-71	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	5-10
11719517-5	2002	In vitro enzyme assays showed that Ahp1p had lower specific activity in strains lacking Cu,Zn-SOD.	Zinc	91-93	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	35-40
21870859-7	2011	By depositing four bilayers [GOD/PAH](4) on the CdSe/ZnS electrode, a fast-responding sensor for the concentration range of 0.1-5 mM glucose can be prepared.	Zinc	53-56	phenylalanine hydroxylase	Homo sapiens	33-39
11802720-3	2002	TAFI was classified as a metallocarboxypeptidase, which contains a Zn(2+), since its amino acid sequence shows approximately 40% identity with pancreatic carboxypeptidases, the Zn(2+) pocket is conserved, and the Zn(2+) chelator o-phenanthroline inhibited TAFIa activity.	Zinc	67-69	carboxypeptidase B2	Homo sapiens	0-4
21756885-5	2011	The co-exposure of fish to Cd and Zn abolished ZnT1 down-regulation and rendered a persistently increased ZIP10 mRNA level.	Zinc	34-36	solute carrier family 30 member 1a	Danio rerio	47-51
11802720-3	2002	TAFI was classified as a metallocarboxypeptidase, which contains a Zn(2+), since its amino acid sequence shows approximately 40% identity with pancreatic carboxypeptidases, the Zn(2+) pocket is conserved, and the Zn(2+) chelator o-phenanthroline inhibited TAFIa activity.	Zinc	177-179	carboxypeptidase B2	Homo sapiens	0-4
11802720-3	2002	TAFI was classified as a metallocarboxypeptidase, which contains a Zn(2+), since its amino acid sequence shows approximately 40% identity with pancreatic carboxypeptidases, the Zn(2+) pocket is conserved, and the Zn(2+) chelator o-phenanthroline inhibited TAFIa activity.	Zinc	177-179	carboxypeptidase B2	Homo sapiens	0-4
11802720-4	2002	In this study we showed that TAFI contained Zn(2+) in a 1:1 molar ratio.	Zinc	44-46	carboxypeptidase B2	Homo sapiens	29-33
21756885-8	2011	The protective effect of dietary Zn supplementation against Cd-induced toxicity is mediated, at least in part, by the increase of Zn availability and subsequently the induction of ZnT1 gene expression.	Zinc	33-35	solute carrier family 30 member 1a	Danio rerio	180-184
11606065-0	2001	Structural insight into human Zn(2+)-bound S100A2 from NMR and homology modeling.	Zinc	30-36	S100 calcium binding protein A2	Homo sapiens	43-49
21116767-6	2011	Furthermore, siRNA-mediated HMGB1 knockdown substantially suppressed NMDA- or Zn(2+)-induced cell death.	Zinc	78-84	high mobility group box 1	Homo sapiens	28-33
11767840-0	2001	Theoretical prediction of A(3)0+ &lt;-- X(1)0+ and B(3)1 &lt;-- X(1)0+ spectra of the Zn-rare gas van der Waal"s molecules.	Zinc	86-88	cytohesin 1 interacting protein	Homo sapiens	40-56
11767840-1	2001	Excitation spectra arising from A(3)0+ &lt;-- X(1)0+ and B(3)1 &lt;-- X(1)0+ electronic transitions in the Zn-rare gas (RG) van der Waal"s molecules are calculated using the newly obtained ab initio potential curves for these species.	Zinc	107-109	cytohesin 1 interacting protein	Homo sapiens	46-62
21510945-2	2011	The influence of divalent zinc (Zn(2+)) as measured by intrinsic fluorescence or FRET in each of these hormones is unique and is affected by the presence of varying stoichiometries of hPRLr.	Zinc	32-38	prolactin receptor	Homo sapiens	184-189
11483663-4	2001	Intracellular accumulation of Zn2+ induced by the combined application of pyrithione (5 microM), a Zn2+ ionophore, and Zn2+ (10 microM) caused cell death and activated JNK and ERK, but not p38 MAPK.	Zinc	30-34	mitogen activated protein kinase 14	Rattus norvegicus	189-192
21351738-3	2011	The Phe-Cys-Ser (FCS) domain, named for three consecutive residues conserved in this domain, is a 30-40-residue Zn(2+) binding motif found in a number of PcG proteins.	Zinc	112-114	Polycomb	Drosophila melanogaster	154-157
11352900-4	2001	In this study we demonstrate that Zn(2+) ions inhibit the uncoupled anion conductance and also reduce the affinity of L-aspartate for EAAT4.	Zinc	34-40	solute carrier family 1 member 6	Homo sapiens	134-139
11352900-6	2001	Two histidine residues in the extracellular loop between transmembrane domains three and four of EAAT4 appear to confer Zn(2+) inhibition of the anion conductance.	Zinc	120-122	solute carrier family 1 member 6	Homo sapiens	97-102
11423399-5	2001	The presence of cysteines at the Q/R/N site in both subunits of NR1/NR2C receptors results in a 220,000-fold increase in sensitivity of the inhibition by extracellular Zn.	Zinc	168-170	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	68-72
11423399-6	2001	In contrast with the high-affinity Zn inhibition of wild-type NR1/NR2A receptors, the high-affinity Zn inhibition of mutated NR1/NR2C receptors shows a voltage dependence, which resembles very much that of the block by extracellular Mg.	Zinc	100-102	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	129-133
11133983-5	2001	In the present study, we have created a Zn(2+) binding site in mGluR1b by mutating the residue Lys(260) to a histidine.	Zinc	40-46	glutamate metabotropic receptor 1	Homo sapiens	63-69
21534604-2	2011	We obtain Cu and Zn MOF-2 structures, which have not yet been obtained using conventional, solvothermal synthesis methods.	Zinc	17-19	lysine acetyltransferase 8	Homo sapiens	20-23
21470317-1	2011	GPR39, which may function as a Zn(2+) sensor, is a member of the G protein-coupled receptor family that also includes the receptor for the hunger hormone ghrelin.	Zinc	31-33	G protein-coupled receptor 39	Mus musculus	0-5
11237510-6	2001	These amounts of Fe and Zn represented 39 and 90% of the NRC requirement for the rat, respectively.	Zinc	24-26	nuclear receptor coactivator 6	Rattus norvegicus	57-60
21078376-8	2011	These results suggest that like diabetes, chronic depletion of Zn with TPEN induces testicular oxidative stress and damage, along with the activation of p38 MAPK and p53 signaling and mitochondria-related apoptotic cell death.	Zinc	63-65	mitogen-activated protein kinase 14	Mus musculus	153-156
21446559-3	2011	In the EDXS and ICPAES analyses, it was found that the molar ratio of Zn/Si was linearly related to the exchanged amount of metal ions, and that the slope of the Zn/Si to the metal/Si was in the order of ZnO/Na-FAU &lt; ZnO/CaNa-FAU &lt; ZnO/ErNa-FAU.	Zinc	162-164	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	211-214
21446559-3	2011	In the EDXS and ICPAES analyses, it was found that the molar ratio of Zn/Si was linearly related to the exchanged amount of metal ions, and that the slope of the Zn/Si to the metal/Si was in the order of ZnO/Na-FAU &lt; ZnO/CaNa-FAU &lt; ZnO/ErNa-FAU.	Zinc	162-164	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	229-232
21446559-3	2011	In the EDXS and ICPAES analyses, it was found that the molar ratio of Zn/Si was linearly related to the exchanged amount of metal ions, and that the slope of the Zn/Si to the metal/Si was in the order of ZnO/Na-FAU &lt; ZnO/CaNa-FAU &lt; ZnO/ErNa-FAU.	Zinc	162-164	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	229-232
21029107-11	2011	Overexpression of GhBCP1 and GhBCP4 in yeast (Schizosaccharomyces pombe) significantly increased the cell growth rate under Cu(2+) , Zn(2+) and high-salinity stresses.	Zinc	133-135	lamin-like protein	Gossypium hirsutum	29-35
20492550-0	2011	Expression of the P(1B) -type ATPase AtHMA4 in tobacco modifies Zn and Cd root to shoot partitioning and metal tolerance.	Zinc	64-66	heavy metal atpase 4	Arabidopsis thaliana	37-43
20492550-3	2011	Expression of AtHMA4 enhanced Zn translocation to the shoots only at 10 muM Zn but not at 0.5, 100 and 200 muM Zn.	Zinc	30-32	heavy metal atpase 4	Arabidopsis thaliana	14-20
20492550-3	2011	Expression of AtHMA4 enhanced Zn translocation to the shoots only at 10 muM Zn but not at 0.5, 100 and 200 muM Zn.	Zinc	76-78	heavy metal atpase 4	Arabidopsis thaliana	14-20
20492550-3	2011	Expression of AtHMA4 enhanced Zn translocation to the shoots only at 10 muM Zn but not at 0.5, 100 and 200 muM Zn.	Zinc	76-78	heavy metal atpase 4	Arabidopsis thaliana	14-20
20492550-4	2011	AtHMA4-trunc did not show this effect and instead reduced Zn translocation to the shoot.	Zinc	58-60	heavy metal atpase 4	Arabidopsis thaliana	0-6
21138269-14	2010	Crystal structures of these double-headed aminopyridine inhibitors in complexes with nNOS show unexpected and significant protein and heme conformational changes induced by inhibitor binding that result in removal of the tetrahydrobiopterin (H(4)B) cofactor and creation of a new Zn(2+) site.	Zinc	280-286	nitric oxide synthase 1	Homo sapiens	85-89
20729526-4	2010	Using partial proteolysis we find that RepE, a folded substrate, contacts a wide DnaJ area that involves part of the G/F-rich region and Zn-binding domain.	Zinc	137-139	replication initiation protein of the FIA replicon	Escherichia coli	39-43
20650903-2	2010	AtHMA4, an Arabidopsis thaliana heavy metal pump of importance for plant Zn(2+) nutrition, has an extended C-terminal domain containing 13 cysteine pairs and a terminal stretch of 11 histidines.	Zinc	73-75	heavy metal atpase 4	Arabidopsis thaliana	0-6
20650903-3	2010	Using a novel size-exclusion chromatography, inductively coupled plasma mass spectrometry approach we report that the C-terminal domain of AtHMA4 is a high affinity Zn(2+) and Cd(2+) chelator with capacity to bind 10 Zn(2+) ions per C terminus.	Zinc	165-167	heavy metal atpase 4	Arabidopsis thaliana	139-145
20650903-3	2010	Using a novel size-exclusion chromatography, inductively coupled plasma mass spectrometry approach we report that the C-terminal domain of AtHMA4 is a high affinity Zn(2+) and Cd(2+) chelator with capacity to bind 10 Zn(2+) ions per C terminus.	Zinc	217-219	heavy metal atpase 4	Arabidopsis thaliana	139-145
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Zinc	30-36	heavy metal atpase 4	Arabidopsis thaliana	5-11
20650903-4	2010	When AtHMA4 is expressed in a Zn(2+)-sensitive zrc1 cot1 yeast strain, sequential removal of the histidine stretch and the cysteine pairs confers a gradual increase in Zn(2+) and Cd(2+) tolerance and lowered Zn(2+) and Cd(2+) content of transformed yeast cells.	Zinc	30-36	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	47-51
20697649-8	2010	Interestingly, attempts to deprotonate 6c with n-BuLi produced unexpectedly the alkylated product [1c]Zn(n-Bu) (7c) instead of [1c]ZnCl; analogous reactions employing NEt3 led to Lewis base substitution to give H[1c] and [ZnCl2(NEt3)]2.	Zinc	102-104	tetraspanin 2	Homo sapiens	167-171
20697649-8	2010	Interestingly, attempts to deprotonate 6c with n-BuLi produced unexpectedly the alkylated product [1c]Zn(n-Bu) (7c) instead of [1c]ZnCl; analogous reactions employing NEt3 led to Lewis base substitution to give H[1c] and [ZnCl2(NEt3)]2.	Zinc	102-104	tetraspanin 2	Homo sapiens	228-232
20711450-7	2010	Given the recent interest in metal-chelation therapies for AD that remove metal from Abeta leaving a metal-free Abeta that can readily bind metals again, we believe that MT-2A might represent a different therapeutic approach as the metal exchange between MT and Abeta leaves the Abeta in a Zn-bound, relatively inert form.	Zinc	290-292	metallothionein 2A	Rattus norvegicus	170-175
20591924-4	2010	Exit from mII can be induced by Zn(2+)-specific sequestration without Ca(2+) release, eliciting Cyclin B degradation in a manner dependent upon the proteasome pathway and intact microtubules, but not accompanied by degradation of the meiotic regulator Emi2.	Zinc	32-38	F-box protein 43	Mus musculus	252-256
20825028-2	2010	The results showed that Cu2+ or Zn2+ adsorption isotherm could significantly conform to Freundlich and Henry equations both for the directly landfilled sludge (SSA) and the solidifying landfilled sludge (SSB).	Zinc	32-36	small RNA binding exonuclease protection factor La	Homo sapiens	204-207
11067850-3	2001	In neuronal NOS (nNOS), there is a conserved cysteine motif (CX(4)C) that participates in a ZnS(4) center, which stabilizes the dimer interface and/or the flavoprotein-heme domain interface.	Zinc	92-95	nitric oxide synthase 1	Homo sapiens	3-15
11067850-3	2001	In neuronal NOS (nNOS), there is a conserved cysteine motif (CX(4)C) that participates in a ZnS(4) center, which stabilizes the dimer interface and/or the flavoprotein-heme domain interface.	Zinc	92-95	nitric oxide synthase 1	Homo sapiens	17-21
20413590-5	2010	In the present study we found that Zn(2+) enhanced the binding of protein C/activated protein C (APC) to endothelial cell protein C receptor (EPCR) on endothelial cells.	Zinc	35-41	protein C receptor	Homo sapiens	105-140
20413590-5	2010	In the present study we found that Zn(2+) enhanced the binding of protein C/activated protein C (APC) to endothelial cell protein C receptor (EPCR) on endothelial cells.	Zinc	35-41	protein C receptor	Homo sapiens	142-146
20413590-6	2010	Binding kinetics revealed that Zn(2+) increased the binding affinities of protein C/APC to EPCR.	Zinc	31-37	structural maintenance of chromosomes 4	Homo sapiens	82-87
20413590-6	2010	Binding kinetics revealed that Zn(2+) increased the binding affinities of protein C/APC to EPCR.	Zinc	31-37	protein C receptor	Homo sapiens	91-95
20413590-8	2010	Intrinsic fluorescence measurements suggested that Zn(2+) binding induces conformational changes in protein C/APC.	Zinc	51-57	structural maintenance of chromosomes 4	Homo sapiens	108-113
20413590-12	2010	Zn(2+) enhanced APC-mediated activation of protease activated receptor 1 and p44/42 MAPK.	Zinc	0-2	interferon induced protein 44	Homo sapiens	77-80
20413590-13	2010	Overall, our data show that Zn(2+) binds to protein C/APC, which results in conformational changes in protein C/APC that favor their binding to EPCR.	Zinc	28-30	structural maintenance of chromosomes 4	Homo sapiens	52-57
20413590-13	2010	Overall, our data show that Zn(2+) binds to protein C/APC, which results in conformational changes in protein C/APC that favor their binding to EPCR.	Zinc	28-30	structural maintenance of chromosomes 4	Homo sapiens	110-115
20413590-13	2010	Overall, our data show that Zn(2+) binds to protein C/APC, which results in conformational changes in protein C/APC that favor their binding to EPCR.	Zinc	28-30	protein C receptor	Homo sapiens	144-148
20228268-3	2010	FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase 1/2 (ERK1/2; mitogen-activated protein kinase 44 [MAPK44] and MAPK42) and Akt (Ser473) phosphorylation in endothelial cells.	Zinc	26-28	coagulation factor XII (Hageman factor)	Mus musculus	0-4
20228268-3	2010	FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase 1/2 (ERK1/2; mitogen-activated protein kinase 44 [MAPK44] and MAPK42) and Akt (Ser473) phosphorylation in endothelial cells.	Zinc	26-28	mitogen-activated protein kinase 3	Mus musculus	82-88
20417934-2	2010	Adsorption of IgG onto CIM-IDA disk immobilized with Cu(2+), Ni(2+) and Zn(2+) were studied with Tris-acetate (TA), phosphate-acetate (PA) and MMA (MES, MOPS and acetate) buffer systems at different flow rates.	Zinc	72-74	immunoglobulin heavy variable V1-62	Mus musculus	14-17
20356629-10	2010	Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells, while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes.	Zinc	11-17	matrix metallopeptidase 2	Homo sapiens	52-57
20411580-1	2010	The native form of Cu,Zn-superoxide dismutase (SOD-1) is a homodimer that coordinates one Cu(2+) and one Zn(2+) per monomer.	Zinc	22-24	superoxide dismutase [Cu-Zn]	Bos taurus	47-52
20411580-5	2010	The metal ions of the native enzyme (Cu(2),Zn(2)-dimer SOD-1) were released in acidic medium in order to obtain apo-SOD-1, which is a monomer.	Zinc	43-48	superoxide dismutase [Cu-Zn]	Bos taurus	116-121
20411580-9	2010	This finding indicated that the metals were released from the Cu(2),Zn(2)-dimer SOD-1 during sample preparation or ionization.	Zinc	68-73	superoxide dismutase [Cu-Zn]	Bos taurus	80-85
20411580-12	2010	However, the electrophoretic profiles and the mass spectra obtained suggested that the metals of Cu(2),Zn(2)-dimer SOD-1 were released, which generated the apo-monomer during the electrophoretic separation.	Zinc	103-106	superoxide dismutase [Cu-Zn]	Bos taurus	115-120
20213043-3	2010	Fluorescence experiment results showed that the oxidative refolding of the demetalated SOD1 (apo-SOD1) is biphasic, and the addition of stoichiometric Zn(2+) into the refolding buffer remarkably accelerates both the fast phase and the slow phase of the oxidative refolding, compared with without Zn(2+).	Zinc	151-153	superoxide dismutase [Cu-Zn]	Bos taurus	87-91
20213043-3	2010	Fluorescence experiment results showed that the oxidative refolding of the demetalated SOD1 (apo-SOD1) is biphasic, and the addition of stoichiometric Zn(2+) into the refolding buffer remarkably accelerates both the fast phase and the slow phase of the oxidative refolding, compared with without Zn(2+).	Zinc	151-153	superoxide dismutase [Cu-Zn]	Bos taurus	97-101
20213043-3	2010	Fluorescence experiment results showed that the oxidative refolding of the demetalated SOD1 (apo-SOD1) is biphasic, and the addition of stoichiometric Zn(2+) into the refolding buffer remarkably accelerates both the fast phase and the slow phase of the oxidative refolding, compared with without Zn(2+).	Zinc	296-298	superoxide dismutase [Cu-Zn]	Bos taurus	87-91
20213043-3	2010	Fluorescence experiment results showed that the oxidative refolding of the demetalated SOD1 (apo-SOD1) is biphasic, and the addition of stoichiometric Zn(2+) into the refolding buffer remarkably accelerates both the fast phase and the slow phase of the oxidative refolding, compared with without Zn(2+).	Zinc	296-298	superoxide dismutase [Cu-Zn]	Bos taurus	97-101
20213043-4	2010	Aggregation of apo-SOD1 in the presence of stoichiometric Zn(2+) is remarkably slower than that in the absence of Zn(2+).	Zinc	58-60	superoxide dismutase [Cu-Zn]	Bos taurus	19-23
20213043-4	2010	Aggregation of apo-SOD1 in the presence of stoichiometric Zn(2+) is remarkably slower than that in the absence of Zn(2+).	Zinc	114-116	superoxide dismutase [Cu-Zn]	Bos taurus	19-23
21108143-5	2010	The obtained IC50 values of Cd2+, Ni2+, and Zn2+ are 0.027, 0.8, and 1 mM, respectively.	Zinc	44-48	CD2 molecule	Bos taurus	28-31
19712047-11	2009	Furthermore, the presence of heparin, Zn2+ or acidic pH was found to protect HRG from plasmin cleavage.	Zinc	38-42	plasminogen	Homo sapiens	86-93
19778152-2	2009	NMR spectra show that TIS11d(TZF) undergoes a transition from disordered to well folded upon binding to Zn and mRNA.	Zinc	104-106	ZFP36 ring finger protein like 2	Homo sapiens	22-28
19538181-3	2009	Previously we showed that a single amino acid mutation in the yeast vacuolar zinc transporter Zrc1 changed its substrate specificity from Zn2+ to Fe2+ and Mn2+ [Lin, Kumanovics, Nelson, Warner, Ward and Kaplan (2008) J. Biol.	Zinc	138-142	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	94-98
19680471-4	2009	We demonstrated that the apparent rate constant value of the LCAT enzyme reaction gives a measure of LCAT activity and determined the effects of free metals and a reducing agent on LCAT activity, showing an inhibition hierarchy of Zn(2+)&gt;Mg(2+)&gt;Ca(2+) and no inhibition with beta-mercaptoethanol up to 10 mM.	Zinc	231-233	lecithin cholesterol acyltransferase	Mus musculus	61-65
19680471-4	2009	We demonstrated that the apparent rate constant value of the LCAT enzyme reaction gives a measure of LCAT activity and determined the effects of free metals and a reducing agent on LCAT activity, showing an inhibition hierarchy of Zn(2+)&gt;Mg(2+)&gt;Ca(2+) and no inhibition with beta-mercaptoethanol up to 10 mM.	Zinc	231-233	lecithin cholesterol acyltransferase	Mus musculus	101-105
19680471-4	2009	We demonstrated that the apparent rate constant value of the LCAT enzyme reaction gives a measure of LCAT activity and determined the effects of free metals and a reducing agent on LCAT activity, showing an inhibition hierarchy of Zn(2+)&gt;Mg(2+)&gt;Ca(2+) and no inhibition with beta-mercaptoethanol up to 10 mM.	Zinc	231-233	lecithin cholesterol acyltransferase	Mus musculus	101-105
19097988-7	2009	As Zn is the only metal known to directly bind MTF-1, we then showed that Ni increased a labile pool of intracellular Zn in cells as revealed by fluorescence-activated cell sorter using the Zn-sensitive fluorophore, FluoZin-3.	Zinc	3-5	metal regulatory transcription factor 1	Homo sapiens	47-52
19513471-1	2009	The interaction between Zn(2+) and the single repeat of PrP-rel-2 of zebrafish at physiological pH was investigated by NMR spectroscopy; the chemical shift mapping and the proton-proton distances were used to obtain the structural model of the Zn(2+) complex.	Zinc	24-26	prion protein a	Danio rerio	56-65
19513471-1	2009	The interaction between Zn(2+) and the single repeat of PrP-rel-2 of zebrafish at physiological pH was investigated by NMR spectroscopy; the chemical shift mapping and the proton-proton distances were used to obtain the structural model of the Zn(2+) complex.	Zinc	244-246	prion protein a	Danio rerio	56-65
19517273-6	2009	Exposure to Zn2+ increased phosphorylation of the MAP-kinases, ERK1/2 and p38, in monocultures of CMs and CFs.	Zinc	12-16	mitogen activated protein kinase 3	Rattus norvegicus	63-69
19517273-6	2009	Exposure to Zn2+ increased phosphorylation of the MAP-kinases, ERK1/2 and p38, in monocultures of CMs and CFs.	Zinc	12-16	mitogen activated protein kinase 14	Rattus norvegicus	74-77
19517273-8	2009	Treatment with a p38 inhibitor (SB202190) reduced the IL-6 responses to Zn2+ and Cu2+ in both cell types.	Zinc	72-76	mitogen activated protein kinase 14	Rattus norvegicus	17-20
19213833-1	2009	G protein-coupled receptor (GPR)-39 is a seven-transmembrane receptor expressed mainly in endocrine and metabolic tissues that acts as a Zn(++) sensor signaling mainly through the G(q) and G(12/13) pathways.	Zinc	137-143	G protein-coupled receptor 39	Mus musculus	0-35
19433490-8	2009	Zn treatment enhanced the expression of several genes involved in Zn tolerance: namely, the plasma membrane Zn(2+)-export ATPase, HMA4, and plasma and vacuolar membrane proton pumps.	Zinc	0-2	heavy metal atpase 4	Arabidopsis thaliana	130-134
19433490-8	2009	Zn treatment enhanced the expression of several genes involved in Zn tolerance: namely, the plasma membrane Zn(2+)-export ATPase, HMA4, and plasma and vacuolar membrane proton pumps.	Zinc	66-68	heavy metal atpase 4	Arabidopsis thaliana	130-134
18947441-7	2009	Also, we established that mRNA levels of the Zn-responsive metal response element binding transcription factor (MTF)-1, and its homologue MTF-2, are regulated by Zn in Caco-2 but not JAR cells, which may in part underlie differential gene responses to Zn in intestinal and placental cells.	Zinc	162-164	metal regulatory transcription factor 1	Homo sapiens	45-118
19118843-0	2009	Monochloramine impairs caspase-3 through thiol oxidation and Zn2+ release.	Zinc	61-65	caspase-3	Oryctolagus cuniculus	23-32
19118843-1	2009	BACKGROUND: Caspase-3, a pro-apoptotic enzyme, represents a class of proteins in which the active site contains reduced thiol (S-H) groups and is modulated by heavy metal cations, such as Zn(2+).	Zinc	188-190	caspase-3	Oryctolagus cuniculus	12-21
19118843-3	2009	In addition, we tested the hypothesis that NH(2)Cl-induced alterations of caspase-3 activity are modulated by oxidant-induced accumulation of Zn(2+) within the cytoplasm.	Zinc	142-148	caspase-3	Oryctolagus cuniculus	74-83
19118843-10	2009	Independently from its thiol oxidant effects on the enzyme, NH(2)Cl-induced accumulation of Zn(2+) in the cytoplasm is sufficient to restrain endogenous caspase-3 activity.	Zinc	92-98	caspase-3	Oryctolagus cuniculus	153-162
19219993-8	2009	In aqueous solutions E(fb) of Zn(2)SnO(4) was found to follow a 59 mV/pH slope with E(fb) extrapolated at pH 0 of 0.08 V vs NHE.	Zinc	30-32	solute carrier family 9 member C1	Homo sapiens	124-127
19267779-2	2009	Metal ion-free S100A2 is homodimeric and contains two Ca(2+)-binding sites and two Zn(2+)-binding sites per subunit, whereby the Zn(2+) ion binding to one of the sites is coordinated by residues from two homodimers.	Zinc	83-89	S100 calcium binding protein A2	Homo sapiens	15-21
19267779-2	2009	Metal ion-free S100A2 is homodimeric and contains two Ca(2+)-binding sites and two Zn(2+)-binding sites per subunit, whereby the Zn(2+) ion binding to one of the sites is coordinated by residues from two homodimers.	Zinc	129-135	S100 calcium binding protein A2	Homo sapiens	15-21
19267779-5	2009	The energy of unfolding (DeltaG(U)) of the apo wild-type S100A2 was determined to be 89.9 kJ mol(-1), and the apparent midpoint transition temperature (T(m)(app))) was 58.4 degrees C. In addition, a detailed study of the urea and thermal unfolding of the S100A2 mutants in different metallation states (apo, Zn(2+) and Ca(2+)) was performed.	Zinc	308-310	S100 calcium binding protein A2	Homo sapiens	57-63
19267779-7	2009	This suggests a synergistic effect between metal binding, protein stability and S100A2 biological activity, according to which Ca(2+) activates and stabilizes the protein, the opposite being observed on Zn(2+) binding.	Zinc	203-209	S100 calcium binding protein A2	Homo sapiens	80-86
18951909-2	2009	We characterized the effect of zinc (Zn(2+)) on the binding properties of the 5-HT(1A) receptor.	Zinc	37-43	5-hydroxytryptamine receptor 1A	Rattus norvegicus	78-85
18951909-4	2009	Zn(2+) (5microM-1mM) inhibited the binding of agonist/antagonist to 5-HT1A receptors, mostly by decreasing both the ligands" affinity and the maximal number of sites.	Zinc	0-2	5-hydroxytryptamine receptor 1A	Rattus norvegicus	68-74
18951909-5	2009	In [(35)S]GTPgammaS binding assays Zn(2+) behaved as insourmountable antagonist of 5-HT1A receptors, in agreement with radioligand binding assays.	Zinc	35-37	5-hydroxytryptamine receptor 1A	Rattus norvegicus	83-89
19046908-5	2009	The results show that Zn(2+) has a strong effect on the NQR parameters (chi, eta) of proximal nitrogen in contrast with the remote nitrogen.	Zinc	22-24	endothelin receptor type A	Homo sapiens	77-80
19046908-6	2009	In addition, EFG tensors at the Zn nuclear site were calculated for Zn-4-MeIm complexes and estimated the chi and eta values of (67)Zn.	Zinc	32-34	endothelin receptor type A	Homo sapiens	114-117
19076718-1	2009	The Zn/Cd-transporting ATPases, HMA2 and HMA4, essential for root-to-shoot Zn translocation, are also able to transport Cd.	Zinc	4-6	heavy metal atpase 4	Arabidopsis thaliana	41-45
19210716-3	2009	IRT3 genes from both A. halleri and A. thaliana functionally complemented the Zn uptake mutant Spzrt1 in Schizosaccharomyces pombe; and Zn uptake double mutant zrt1zrt2, Fe-uptake mutant fet3fet4 and conferred Zn and Fe uptake activity in Saccharomyces cerevisiae.	Zinc	78-80	iron regulated transporter 3	Arabidopsis thaliana	0-4
19210716-3	2009	IRT3 genes from both A. halleri and A. thaliana functionally complemented the Zn uptake mutant Spzrt1 in Schizosaccharomyces pombe; and Zn uptake double mutant zrt1zrt2, Fe-uptake mutant fet3fet4 and conferred Zn and Fe uptake activity in Saccharomyces cerevisiae.	Zinc	136-138	iron regulated transporter 3	Arabidopsis thaliana	0-4
19210716-3	2009	IRT3 genes from both A. halleri and A. thaliana functionally complemented the Zn uptake mutant Spzrt1 in Schizosaccharomyces pombe; and Zn uptake double mutant zrt1zrt2, Fe-uptake mutant fet3fet4 and conferred Zn and Fe uptake activity in Saccharomyces cerevisiae.	Zinc	136-138	iron regulated transporter 3	Arabidopsis thaliana	0-4
19210716-7	2009	Overexpressing AtIRT3 in A. thaliana led to increased accumulation of Zn in the shoot and Fe in the root of transgenic lines.	Zinc	70-72	iron regulated transporter 3	Arabidopsis thaliana	15-21
19210716-8	2009	Therefore, IRT3 functions as a Zn and Fe-uptake transporter in Arabidopsis.	Zinc	31-33	iron regulated transporter 3	Arabidopsis thaliana	11-15
18823081-3	2008	Under identical solvent (propylene carbonate)/electrolyte (1.0 M Bu 4NCl) conditions, the Zn (II) center has a coordinated Cl (-) ion when the porphyrin is in either the neutral or oxidized state.	Zinc	90-97	nucleolin	Homo sapiens	69-72
18313216-4	2008	With the expression of MerP protein, the metal adsorption capacity of the recombinant strains for Ni(2+), Zn(2+) and Cr(3+) significantly improved.	Zinc	106-108	mercuric transport protein periplasmic component MerP	Escherichia coli	23-27
18313216-5	2008	The cells carrying Gram-positive merP gene (GB) adsorbed Zn(2+) and Cr(3+) at a capacity of 22.3 and 0.98 mmol/g biomass, which is 121% and 72% higher, respectively, over that of the MerP-free host cells.	Zinc	57-59	mercuric transport protein periplasmic component MerP	Escherichia coli	33-37
18313216-6	2008	Adsorption capacity of the cells carrying Gram-negative merP gene (GP) also increased 144% and 126% for Zn(2+) and Cr(3+), respectively.	Zinc	104-106	mercuric transport protein periplasmic component MerP	Escherichia coli	56-60
18624907-7	2008	Pharmacological maneuvers revealed that a number of endogenous oxidant producing systems, including nitric oxide synthase, phospholipase A(2), and mitochondria all contributed to glutamate-induced [Zn(2+)](i) changes.	Zinc	198-200	phospholipase A and acyltransferase 1	Rattus norvegicus	123-138
19049196-4	2008	The X-ray diffraction analysis shows that the crystalline size of pure ZnO is 36 nm and it is 41 nm while doped with 0.8 mol% of GaN due to best stoichiometry between Zn and O. Photoluminescence studies reveal that intense deep level emissions have been observed for pure ZnO and it has been suppressed for the GaN doped ZnO structures.	Zinc	71-73	gigaxonin	Homo sapiens	129-132
19049196-4	2008	The X-ray diffraction analysis shows that the crystalline size of pure ZnO is 36 nm and it is 41 nm while doped with 0.8 mol% of GaN due to best stoichiometry between Zn and O. Photoluminescence studies reveal that intense deep level emissions have been observed for pure ZnO and it has been suppressed for the GaN doped ZnO structures.	Zinc	71-73	gigaxonin	Homo sapiens	311-314
18510578-7	2008	RESULTS: The best-fit curves of 0.1 units neuraminidase-treated red blood cells indicated that ZN decreased by 76% and 1/lambda decreased by 8% compared to intact red blood cells.	Zinc	95-97	neuraminidase 1	Homo sapiens	42-55
18510578-9	2008	CONCLUSION: The present study shows that the change in ZN for neuraminidase-treated cells was very large, but the cells did not become agglutinable.	Zinc	55-57	neuraminidase 1	Homo sapiens	62-75
18613978-4	2008	Tat binds two Zn2+ ions through its conserved cysteine-rich region in vitro, but the role of zinc in the structure and properties of Tat is still controversial.	Zinc	14-18	tyrosine aminotransferase	Homo sapiens	0-3
18596163-4	2008	We show that Zn2+ exerts an inhibitory modulatory effect on (alpha4)(2)(beta2)(3) receptors, whereas it potentiates or inhibits, depending on its concentration, the function of (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
18596163-4	2008	We show that Zn2+ exerts an inhibitory modulatory effect on (alpha4)(2)(beta2)(3) receptors, whereas it potentiates or inhibits, depending on its concentration, the function of (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	189-194
18596163-5	2008	Furthermore, Zn2+ inhibition on (alpha4)(2)(beta2)(3) nAChRs is voltage-dependent, whereas it is not on (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	44-49
18596163-7	2008	Zn(2+) inhibition is mediated by a site located on the beta2(+)/alpha4(-) subunit interfaces on both receptor stoichiometries.	Zinc	0-2	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-60
18596163-9	2008	Zn2+ potentiation on (alpha4)(3)(beta2)(2) nAChRs is exerted by a site that resides on the alpha4(+)/alpha4(-) of this receptor stoichiometry.	Zinc	0-4	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	33-38
18596163-11	2008	We also identified residues within the beta2 subunit that confer voltage dependency to Zn2+ inhibition on (alpha4)(2)(beta2)(3), but not on (alpha4)(3)(beta2)(2) nAChRs.	Zinc	87-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-44
18596163-11	2008	We also identified residues within the beta2 subunit that confer voltage dependency to Zn2+ inhibition on (alpha4)(2)(beta2)(3), but not on (alpha4)(3)(beta2)(2) nAChRs.	Zinc	87-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
18596163-11	2008	We also identified residues within the beta2 subunit that confer voltage dependency to Zn2+ inhibition on (alpha4)(2)(beta2)(3), but not on (alpha4)(3)(beta2)(2) nAChRs.	Zinc	87-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
20126369-8	2008	The results showed that in in vitro study, Zn-adequate group induced more VCAM-1 &amp; ICAM-1 mRNA expression than Zn-deficient group during 6-hour zinc treatment post-5 hour TNF-alpha treatment, unexpectedly.	Zinc	43-45	intercellular adhesion molecule 1	Mus musculus	87-93
17566863-5	2008	The samples from IS1, IS2, and IS3, located in the Talcahuano industrial park, had higher Cr, Ni, Pb, and Zn contents than did samples from the other sites.	Zinc	106-108	chromodomain helicase DNA binding protein 7	Homo sapiens	31-34
18174269-8	2008	In contrast, 2 days after CM there was a significant rise in cystatin C in the Zn (P = 0.012) and the placebo (P = 0.041) group, whereas NAC prevented this deterioration of kidney function.	Zinc	79-81	cystatin C	Homo sapiens	61-71
18022240-2	2008	We have used fluorimetry and transmission electron microscopy to investigate in vitro the influence of Al(III), Fe(III), Zn(II) and Cu(II) on amylin amyloid formation under near-physiological conditions.	Zinc	121-127	islet amyloid polypeptide	Homo sapiens	142-148
18184566-2	2008	In NMDA receptors (NMDARs), the NTDs of NR2A and NR2B subunits also form binding sites for the endogenous inhibitor Zn(2+) ion.	Zinc	116-118	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	49-53
18054826-5	2008	The zinc (Zn) concentration increased significantly in the intestinal cytosol and plasma during the time the mice were fed the low-Ca diet, and expression of both MT-1 and ZnT-1 sharply increased with a similar time course.	Zinc	10-12	solute carrier family 30 (zinc transporter), member 1	Mus musculus	172-177
18054826-7	2008	These results suggest that CaT1 may stimulate the intestinal absorption of Cd and Zn, and some Cd may be distributed to the kidneys along with MT induced by Zn.	Zinc	82-84	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	27-31
18040680-7	2008	The highest specific activity (472 U(SOD) mg(prot) (-1)) and the highest volumetric yield (8.8 x 10(5) U(SOD) l(-1)) were obtained by the recombinant strain overexpressing KmSOD1 in the presence of Cu(2+) and Zn(2+) supplements to the culture media.	Zinc	209-215	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	37-40
10987280-5	2000	The amino acid sequence of matrilysin-2 also contains a threonine residue adjacent to the Zn-binding site that has been defined as a specific feature of matrilysin.	Zinc	90-92	matrix metallopeptidase 26	Homo sapiens	27-39
10987280-5	2000	The amino acid sequence of matrilysin-2 also contains a threonine residue adjacent to the Zn-binding site that has been defined as a specific feature of matrilysin.	Zinc	90-92	matrix metallopeptidase 7	Homo sapiens	27-37
10856290-5	2000	X-ray fluorescence spectra revealed that RPA70-CTD possesses a coordinated Zn(II).	Zinc	75-81	replication protein A1	Homo sapiens	41-46
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	27-29	replication protein A1	Homo sapiens	86-91
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	27-29	replication protein A1	Homo sapiens	86-95
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	27-29	replication protein A1	Homo sapiens	102-111
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	166-168	replication protein A1	Homo sapiens	86-91
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	166-168	replication protein A1	Homo sapiens	86-95
10856290-9	2000	Our data indicate that (i) Zn(II) is essential to stabilize the tertiary structure of RPA70-CTD; (ii) RPA70-CTD possesses DNA-binding activity, which is modulated by Zn(II); and (iii) ssDNA binding by the trimer is a synergistic effect generated by the RPA70-CTD and RPA32.	Zinc	166-168	replication protein A1	Homo sapiens	102-111
10816589-11	2000	Although not observed on native gels, the inhibitory receptor KIR2DL1 can be chemically cross-linked into dimers in the presence of Zn(2+) and its related divalent metal ions, suggesting that Co(2+)-mediated dimerization of KIR2DL1 may mimic a weaker interaction between KIR2DL1 and zinc in vivo.	Zinc	132-134	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	62-69
10903508-2	2000	By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.	Zinc	131-135	prothymosin alpha pseudogene 9	Homo sapiens	9-26
10903508-2	2000	By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.	Zinc	131-135	prothymosin alpha pseudogene 9	Homo sapiens	144-161
10903508-3	2000	This finding was further confirmed by the equilibrium dialysis analysis which demonstrated that, within the micromolar range of Zn2+ concentrations, prothymosin alpha could bind up to three zinc ions in the presence of 100 mM NaCl and up to 13 zinc ions in the absence of NaCl.	Zinc	128-132	prothymosin alpha pseudogene 9	Homo sapiens	149-166
10903508-5	2000	The effects of Zn2+ and Ca2+ on the interaction of prothymosin alpha with its putative partners, Rev of HIV type 1 and histone H1, were examined.	Zinc	15-19	prothymosin alpha pseudogene 9	Homo sapiens	51-68
10971626-5	2000	The releasing effect of gp120 was prevented by blocking the glycine site or the ion channel of NMDA receptors, but not the glutamate recognition site; in addition, the gp120 effect was strongly inhibited by nanomolar concentrations of Zn2+ ions and by low micromolar concentrations of ifenprodil.	Zinc	235-239	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	24-29
10971626-5	2000	The releasing effect of gp120 was prevented by blocking the glycine site or the ion channel of NMDA receptors, but not the glutamate recognition site; in addition, the gp120 effect was strongly inhibited by nanomolar concentrations of Zn2+ ions and by low micromolar concentrations of ifenprodil.	Zinc	235-239	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	168-173
10971626-8	2000	The sensitivity of the gp120 effect to both Zn2+ and ifenprodil would not be incompatible with the idea that these NMDA receptors contain the triple subunit combination NR1/NR2A/NR2B.	Zinc	44-48	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	23-28
10850795-0	2000	Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor.	Zinc	11-15	coagulation factor III, tissue factor	Homo sapiens	114-127
10850795-5	2000	Binding of Zn2+ to FVIIa, which was influenced by the presence of Ca2+, resulted in decreased amidolytic activity and slightly reduced affinity for TF.	Zinc	11-15	coagulation factor III, tissue factor	Homo sapiens	148-150
10807182-3	2000	The proton-assisted dissociation of [Gd(DTPA)]2- is relatively slow (k1 = 0.58+/-0.22 M(-1) s(-1)), and under physiological conditions the release of Gd3+ predominantly occurs through the reactions of the complex with the Cu2+ and Zn2+ ions.	Zinc	231-235	GRDX	Homo sapiens	150-153
10703927-9	2000	In addition, Zn2+ inhibited annexin II-, V-, and VI-mediated Ca2+ influx into liposomes.	Zinc	13-17	annexin A2	Homo sapiens	28-38
10639099-10	2000	With both agonists, Zn2+ altered the open probability of the alpha1 GlyR without changing its unitary conductance.	Zinc	20-24	glycine receptor alpha 1	Homo sapiens	61-72
10639099-13	2000	Site-directed mutagenesis of the GlyR alpha1 subunit identified aspartate 80 and threonine 112 as important determinants of Zn2+ potentiation and inhibition, respectively, without affecting potentiation by ethanol.	Zinc	124-128	glycine receptor alpha 1	Homo sapiens	33-44
10639099-15	2000	Our data support the view that Zn2+ modulates different steps of the receptor binding and gating cycle via specific allosteric high- and low-affinity binding sites in the extracellular N-terminal region of the GlyR alpha1 subunit.	Zinc	31-35	glycine receptor alpha 1	Homo sapiens	210-221
10617612-1	2000	The heme activator protein Hap1 is a member of the yeast Gal4 family, which consists of transcription factors with a conserved Zn(2)Cys(6) cluster that recognizes a CGG triplet.	Zinc	127-129	Hap1p	Saccharomyces cerevisiae S288C	27-31
10630627-4	1999	The activities of thioredoxin reductase in intact or disrupted mitochondria were decreased by dopamine (1-100 microM), 25 microM Zn2+ and 50 microM Mn2+.	Zinc	129-133	peroxiredoxin 5	Homo sapiens	18-39
10346818-4	1999	By replacing the carboxy-terminal TRAF domain of TRAF2 and TRAF6 with repeats of the immunophilin FKBP12, we demonstrate that their effector domains are composed of their amino-terminal Zn and RING fingers.	Zinc	186-188	TNF receptor associated factor 6	Homo sapiens	59-64
10216093-3	1999	Physiologic concentrations of Zn2+ increased the urokinase receptor (uPAR)-mediated adhesion of myelomonocytic cells to VN, whereas other divalent cations had smaller effects.	Zinc	30-34	plasminogen activator, urokinase receptor	Homo sapiens	69-73
10216093-4	1999	Zn2+-induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline, as well as by plasminogen activator inhibitor-1 (PAI-1) and a monoclonal antibody (MoAb) against uPAR.	Zinc	0-4	serpin family E member 1	Homo sapiens	110-143
10216093-4	1999	Zn2+-induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline, as well as by plasminogen activator inhibitor-1 (PAI-1) and a monoclonal antibody (MoAb) against uPAR.	Zinc	0-4	serpin family E member 1	Homo sapiens	145-150
10216093-4	1999	Zn2+-induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline, as well as by plasminogen activator inhibitor-1 (PAI-1) and a monoclonal antibody (MoAb) against uPAR.	Zinc	0-4	plasminogen activator, urokinase receptor	Homo sapiens	193-197
10216093-5	1999	These characteristics could be recapitulated with a uPAR-transfected cell line emphasizing the specificity of this receptor system for Zn2+-dependent cell adhesion.	Zinc	135-139	plasminogen activator, urokinase receptor	Homo sapiens	52-56
10216093-6	1999	Like urokinase (uPA), Zn2+ increased the binding of radiolabeled VN to uPAR-expressing cells, as well as the interaction of VN with immobilized uPAR in an isolated system.	Zinc	22-26	plasminogen activator, urokinase receptor	Homo sapiens	71-75
10216093-8	1999	Instead of the direct beta2-integrin activation through the divalent cation binding site, Zn2+-induced integrin activation was mediated via uPAR, a crucial regulator of this system.	Zinc	90-94	plasminogen activator, urokinase receptor	Homo sapiens	140-144
18040680-7	2008	The highest specific activity (472 U(SOD) mg(prot) (-1)) and the highest volumetric yield (8.8 x 10(5) U(SOD) l(-1)) were obtained by the recombinant strain overexpressing KmSOD1 in the presence of Cu(2+) and Zn(2+) supplements to the culture media.	Zinc	209-215	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	105-108
17803461-8	2008	On the other hand, H2O2 was suggested to induce a release of Zn2+ from the C1 domain of beta2-chimaerin.	Zinc	61-65	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-93
10204240-3	1999	The following selectivity sequences we found for pectins: Pb2+ &gt;&gt; Cu2+ &gt; Co2+ &gt; Ni2+ &gt;&gt; Zn2+ &gt; Cd2+.	Zinc	106-110	complement C2	Homo sapiens	82-85
19190768-2	2008	Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile.	Zinc	8-10	cut like homeobox 1	Homo sapiens	149-152
17901898-8	2007	While addition of Fe2+ did not reverse inhibition, the addition of Zn2+ resulted in a recovery of MMP-2 activity, and furthermore, zinc-saturated LTF did not inhibit MMP-2.	Zinc	67-71	matrix metallopeptidase 2	Homo sapiens	98-103
17883856-2	2007	Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly(ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.	Zinc	0-2	clusterin	Homo sapiens	156-160
17644060-4	2007	Residues in the second Zn-finger loop (Gln49, Arg52), which contribute to C-domain dimerization on DR1 response elements, proved essential to IGFBP-3 binding.	Zinc	23-25	down-regulator of transcription 1	Homo sapiens	99-102
17762108-2	2007	The structure of the compound exhibits a two-dimensional layer, which is formed by the interconnection of [Zn(C(7)H(6)NO(2))(H2O)]n chains via mu2-nitrate bridges or by the interconnection of [Zn(NO(3))(H2O)]n chains via mu2-4-aminobenzoate bridges.	Zinc	107-109	adaptor related protein complex 1 subunit mu 2	Homo sapiens	143-146
10228009-8	1999	Furthermore, IL-17 induction of the CINC promoter could be inhibited by kinase-negative mutants of NF-kappa B-inducing kinase and I kappa B kinase-alpha.	Zinc	36-40	interleukin 17A	Rattus norvegicus	13-18
10402203-0	1999	Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.	Zinc	90-94	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	113-126
10402203-1	1999	Zinc (Zn2+) inhibition of N-methyl-D-aspartate receptor (NMDAR) activity involves both voltage-independent and voltage-dependent components.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	26-55
10402203-1	1999	Zinc (Zn2+) inhibition of N-methyl-D-aspartate receptor (NMDAR) activity involves both voltage-independent and voltage-dependent components.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	57-62
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	12-15
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	25-28
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	29-33
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	25-28
10402203-2	1999	Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively).	Zinc	109-113	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	25-28
10402203-5	1999	We suggest that the mechanism of high-affinity Zn2+ inhibition on the NMDAR involves enhancement of proton inhibition.	Zinc	47-51	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	70-75
9915851-9	1999	Rabbit reticulocyte ALA-D is about as active in converting delta-aminolevulinic acid to porphobilinogen and as Zn2+-dependent as ALA-D purified from other sources.	Zinc	111-115	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	20-25
9915851-9	1999	Rabbit reticulocyte ALA-D is about as active in converting delta-aminolevulinic acid to porphobilinogen and as Zn2+-dependent as ALA-D purified from other sources.	Zinc	111-115	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	129-134
9872993-6	1999	We show that Zn2+ induction of a stably transfected, metallothionein promoter-regulated mxi1 gene blocked the ability of serum to induce transcription of the endogenous c-myc gene and cell entry into S phase.	Zinc	13-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	169-174
9915892-2	1999	Alpha2-macroglobulin (alpha2-M), a major Zn-binding ligand in serum, presents a potential vehicle for mammary Zn uptake.	Zinc	41-43	alpha-2-macroglobulin	Homo sapiens	0-20
9915892-2	1999	Alpha2-macroglobulin (alpha2-M), a major Zn-binding ligand in serum, presents a potential vehicle for mammary Zn uptake.	Zinc	41-43	alpha-2-macroglobulin	Homo sapiens	22-30
9915892-2	1999	Alpha2-macroglobulin (alpha2-M), a major Zn-binding ligand in serum, presents a potential vehicle for mammary Zn uptake.	Zinc	110-112	alpha-2-macroglobulin	Homo sapiens	0-20
9915892-2	1999	Alpha2-macroglobulin (alpha2-M), a major Zn-binding ligand in serum, presents a potential vehicle for mammary Zn uptake.	Zinc	110-112	alpha-2-macroglobulin	Homo sapiens	22-30
9915892-10	1999	Results from this study present evidence for receptor-mediated uptake of alpha2-M in human mammary epithelial cells, which in turn, provides a potential mechanism for Zn acquisition by the cell.	Zinc	167-169	alpha-2-macroglobulin	Homo sapiens	73-81
10473265-6	1999	This possibility was also suggested by the findings that Zn2+ and Cd2+, known blockers of voltage-dependent proton conductances, reduced the magnitude of the rise in pHi observed during anoxia.	Zinc	57-61	glucose-6-phosphate isomerase	Rattus norvegicus	166-169
12136178-2	1999	The results showed that MT-II promoter could be activated by the induction with 160 &amp;mgr;mol/L Zn(2+) and the expression of Bcl-2 plays an important role in apoptosis of SGC7901 cells.	Zinc	99-101	metallothionein 2A	Homo sapiens	24-29
12548830-1	1999	In this paper, extraction chromatography by which Co2+ can be separated from Cu2+, Cd2+, Mn2+, Zn2+, Fe3+ is developed.	Zinc	95-99	complement C2	Homo sapiens	50-53
12548830-5	1999	The results indicated that this extraction chromatographic method is good to separate Co2+ from Cu2+, Cd2+, Mn2+, Zn2+ and Fe3+, and the condition of separation is simple and convenient.	Zinc	114-118	complement C2	Homo sapiens	86-89
9830036-4	1998	In an in vitro binding reaction, Zn2+ mediates p56(lck) association with a glutathione S-transferase (GST) fusion protein containing the cytosolic domains of CD4 or CD8alpha; no other metals tested support binding.	Zinc	33-37	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
17762108-2	2007	The structure of the compound exhibits a two-dimensional layer, which is formed by the interconnection of [Zn(C(7)H(6)NO(2))(H2O)]n chains via mu2-nitrate bridges or by the interconnection of [Zn(NO(3))(H2O)]n chains via mu2-4-aminobenzoate bridges.	Zinc	107-109	adaptor related protein complex 1 subunit mu 2	Homo sapiens	221-224
17762108-2	2007	The structure of the compound exhibits a two-dimensional layer, which is formed by the interconnection of [Zn(C(7)H(6)NO(2))(H2O)]n chains via mu2-nitrate bridges or by the interconnection of [Zn(NO(3))(H2O)]n chains via mu2-4-aminobenzoate bridges.	Zinc	107-110	adaptor related protein complex 1 subunit mu 2	Homo sapiens	143-146
17762108-2	2007	The structure of the compound exhibits a two-dimensional layer, which is formed by the interconnection of [Zn(C(7)H(6)NO(2))(H2O)]n chains via mu2-nitrate bridges or by the interconnection of [Zn(NO(3))(H2O)]n chains via mu2-4-aminobenzoate bridges.	Zinc	107-110	adaptor related protein complex 1 subunit mu 2	Homo sapiens	221-224
17766394-6	2007	The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure.	Zinc	89-91	ubiquitin specific peptidase 5	Homo sapiens	39-43
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	35-38
9830036-5	1998	Treatment of preformed GST-CD4.p56(lck) dimers with the Zn2+ chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic acid results in dissociation of GST-CD4 from p56(lck), consistent with the finding of Huse et al.	Zinc	56-60	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	175-178
17520746-2	2007	Previously, we demonstrated that Zn activates TrkB in cultured cortical neurons in a metalloproteinase (MP)-dependent manner.	Zinc	33-35	neurotrophic receptor tyrosine kinase 2	Homo sapiens	46-50
9843713-7	1998	Zn deficiency reduced plasma apoA-I and hepatic apoA-I mRNA levels 13 and 38%, respectively, in ZD rats.	Zinc	0-2	apolipoprotein A1	Rattus norvegicus	29-35
9843713-7	1998	Zn deficiency reduced plasma apoA-I and hepatic apoA-I mRNA levels 13 and 38%, respectively, in ZD rats.	Zinc	0-2	apolipoprotein A1	Rattus norvegicus	48-54
9843713-8	1998	The 2 days of Zn replenishment raised plasma apoA-I and hepatic apoA-I mRNA levels in ZDA rats by 34 and 28%, respectively, higher than ZA rats.	Zinc	14-16	apolipoprotein A1	Rattus norvegicus	45-51
17520746-10	2007	Because Cu, like Zn, is released in certain brain areas with neuronal activity, metal-triggered TrkB activation may occur in both Cu- and Zn-containing synapses.	Zinc	17-19	neurotrophic receptor tyrosine kinase 2	Homo sapiens	96-100
9843713-8	1998	The 2 days of Zn replenishment raised plasma apoA-I and hepatic apoA-I mRNA levels in ZDA rats by 34 and 28%, respectively, higher than ZA rats.	Zinc	14-16	apolipoprotein A1	Rattus norvegicus	64-70
17520746-10	2007	Because Cu, like Zn, is released in certain brain areas with neuronal activity, metal-triggered TrkB activation may occur in both Cu- and Zn-containing synapses.	Zinc	138-140	neurotrophic receptor tyrosine kinase 2	Homo sapiens	96-100
9843713-11	1998	Data from this study demonstrated that Zn deficiency specifically decreases hepatic apoA-I gene expression, which may at least be partly responsible for the reduction of plasma apoA-I levels.	Zinc	39-41	apolipoprotein A1	Rattus norvegicus	84-90
17544408-1	2007	Endostatin has a compact structure with a Zn(II)-binding site (His1, His3, His11, and Asp76) at the N-terminus.	Zinc	42-48	viral integration site 1	Homo sapiens	63-67
9843713-11	1998	Data from this study demonstrated that Zn deficiency specifically decreases hepatic apoA-I gene expression, which may at least be partly responsible for the reduction of plasma apoA-I levels.	Zinc	39-41	apolipoprotein A1	Rattus norvegicus	177-183
9850069-11	1998	In addition, the expression of bax protein, an apoptosis accelerator, was markedly stronger in esophagi from Zn-/DFMO+ animals that showed increased apoptosis, whereas increased expression of bcl-2, an inhibitor of apoptosis, was only seen in the highly proliferative, zinc-deficient esophagus (Zn-/DFMO-).	Zinc	109-111	BCL2 associated X, apoptosis regulator	Rattus norvegicus	31-34
9850069-11	1998	In addition, the expression of bax protein, an apoptosis accelerator, was markedly stronger in esophagi from Zn-/DFMO+ animals that showed increased apoptosis, whereas increased expression of bcl-2, an inhibitor of apoptosis, was only seen in the highly proliferative, zinc-deficient esophagus (Zn-/DFMO-).	Zinc	295-297	BCL2 associated X, apoptosis regulator	Rattus norvegicus	31-34
9831543-5	1998	Treatment of HPT cells with Cd2+, Zn2+, or Cu2+ increased the levels of MT-1E and MT-1A mRNA, but not the levels of MT-1X or MT-1F mRNA.	Zinc	34-38	metallothionein 1E	Homo sapiens	72-77
9822722-8	1998	This conclusion is supported by data showing that divalent cations such as Cd2+ and Zn2+ (50-200 microM) slowed closed-state inactivation and also dramatically increased the ramp currents for DRG TTX-S currents and hNE channels but not for hSkM1 channels.	Zinc	84-88	sodium voltage-gated channel alpha subunit 4	Homo sapiens	240-245
9611200-2	1998	We now report that imp2 null mutants are also extremely sensitive to elevated levels of the monovalent ions, Na+ and Li+, as well as to the divalent ions Ca2+, Mn2+, Zn2+, and Cu2+, but not to Cd2+, Mg2+, Co2+, Ni2+, and Fe2+, as compared to the parent strain.	Zinc	166-170	endopeptidase catalytic subunit	Saccharomyces cerevisiae S288C	19-23
9581874-8	1998	Assuming that the nonlinear plots were caused by ligand-induced negative cooperativity, Zn2+ and Cd2+ lowered both Ke and Kf (affinity of unoccupied and saturated IGFBPs, respectively).	Zinc	88-92	insulin like growth factor binding protein 3	Homo sapiens	163-169
9636993-2	1998	The Zn-Npy distances range from 1.979 (5) to 1.999 (5) A, while the Zn-Namine distance is 2.028 (5) A.	Zinc	4-6	neuropeptide Y	Homo sapiens	7-10
29711230-1	1998	With CoI corrins as supernucleophiles, methylation by methanol is achieved when the leaving group is activated by Zn2+ ions at elevated temperatures (see reaction below).	Zinc	114-118	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	5-8
9504955-10	1998	This study also revealed an effect of Zn to increase serum osteocalcin (P &lt; 0.03 at 2x normal Zn).	Zinc	38-40	bone gamma-carboxyglutamate protein 2	Mus musculus	59-70
9504955-10	1998	This study also revealed an effect of Zn to increase serum osteocalcin (P &lt; 0.03 at 2x normal Zn).	Zinc	97-99	bone gamma-carboxyglutamate protein 2	Mus musculus	59-70
9528981-4	1998	Zn2+, Au3+, and Cd2+ depressed binding of both [125I]-IGF-I and [125I]-IGF-II.	Zinc	0-4	insulin like growth factor 2	Homo sapiens	71-77
9464918-6	1997	Both picrotoxin (0.5 nM to 10 microM) and Zn2+ (10 nM to 100 microM) reduced the resting membrane conductance for beta3 cDNA-injected oocytes.	Zinc	42-46	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	114-119
9464918-9	1997	It was concluded that beta3 subunits form spontaneously opening ion channels that can be up-regulated by some allosteric modulators, principally by pentobarbitone and propofol and, surprisingly, by bicuculline and strychnine, whilst picrotoxin and Zn2+ acted as antagonists.	Zinc	248-252	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	22-27
33863068-5	1997	Zn2+ was found to significantly ameliorate the toxicity of Cd2+ to three of the four isolates tested.	Zinc	0-4	CD2 molecule	Homo sapiens	59-62
17408612-2	2007	Recent literature has shown Zn2+ inhibits dopamine transport by the dopamine transporter (DAT), the main target of cocaine and some other drugs of abuse.	Zinc	28-32	solute carrier family 6 member 3	Rattus norvegicus	68-88
17408612-2	2007	Recent literature has shown Zn2+ inhibits dopamine transport by the dopamine transporter (DAT), the main target of cocaine and some other drugs of abuse.	Zinc	28-32	solute carrier family 6 member 3	Rattus norvegicus	90-93
17408612-3	2007	Cocaine inhibits DAT and modulation of the DAT by Zn2+ may alter effects of cocaine on dopamine neurotransmission.	Zinc	50-54	solute carrier family 6 member 3	Rattus norvegicus	43-46
17408612-4	2007	This study investigates how Zn2+ changes DAT kinetics and its inhibition by cocaine.	Zinc	28-32	solute carrier family 6 member 3	Rattus norvegicus	41-44
17408612-13	2007	Modulation of the DAT by Zn2+ needs to be assessed further in development of cocaine antagonists.	Zinc	25-29	solute carrier family 6 member 3	Rattus norvegicus	18-21
17360717-9	2007	Processing and enzymatic activation of HDC in P-815 cells was enhanced in the presence of a Zn(2+) chelator, TPEN.	Zinc	92-94	histidine decarboxylase	Mus musculus	39-42
17367129-5	2007	The beta1 and beta2 global formation constants for the [M(LOH)]2+ and [M(LOH)2]2+ species were obtained and are in agreement with the Irving-Williams series: Ni2+&lt; Cu2+&gt; Zn2+.	Zinc	176-180	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	14-19
20535382-4	2007	Also, the expression of bone-related genes (ALP, Runx2, PTH-R, ProCOL I, OPN and OC) was measured on the cellular Zn depletion such as chelexing or TPEN treatment.	Zinc	114-116	parathyroid hormone	Mus musculus	56-59
20535382-4	2007	Also, the expression of bone-related genes (ALP, Runx2, PTH-R, ProCOL I, OPN and OC) was measured on the cellular Zn depletion such as chelexing or TPEN treatment.	Zinc	114-116	secreted phosphoprotein 1	Mus musculus	73-76
17298084-6	2007	Upon coordination with Zn2+, full reduction of Erv2p requires 6 electrons.	Zinc	23-27	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	47-52
9288917-1	1997	N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (PPH, human meprin) is a member of the astacin family of Zn-metalloendopeptidases and is highly expressed in the microvillus membrane of human small intestinal epithelial cells.	Zinc	107-109	enolase 1	Homo sapiens	51-54
9242408-4	1997	We have now identified a new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.	Zinc	134-138	solute carrier family 11 member 2	Homo sapiens	63-67
9240471-5	1997	It is shown that the eIF-5-encoded protein binds to single-stranded DNA and to polyuridylic acid and that the binding is dependent on the presence of Zn2+ ions.	Zinc	150-154	eukaryotic translation initiation factor 5	Zea mays	21-26
9111349-2	1997	Acquisition of DNA-binding capacity in the presence of free zinc was temperature and time dependent and did not occur at 4 degrees C. In contrast, activated MTF-1 binding to the metal response element occurred at 4 degrees C. After Zn activation, mouse MTF-1 binding activity was more sensitive to EDTA and was stabilized by DNA binding relative to the Zn finger transcription factor Sp1.	Zinc	232-234	metal response element binding transcription factor 1	Mus musculus	157-162
9111349-3	1997	After dilution of nuclear or whole-cell extracts from Zn-treated cells and incubation at 37 degrees C, mouse MTF-1 DNA-binding activity was no longer detected but could be completely reconstituted by the subsequent readdition of zinc.	Zinc	54-56	metal response element binding transcription factor 1	Mus musculus	109-114
9111349-4	1997	In vitro-synthesized, recombinant mouse MTF-1 displayed a similar, reversible temperature- and Zn-dependent activation of DNA-binding activity.	Zinc	95-97	metal response element binding transcription factor 1	Mus musculus	40-45
9111349-5	1997	Analysis of deletion mutants of recombinant MTF-1 suggests that the Zn finger domain is important for the Zn-dependent activation of DNA-binding capacity.	Zinc	68-70	metal response element binding transcription factor 1	Mus musculus	44-49
9070268-3	1997	The activity gel assays and HeLa cell nuclear assays for DNase revealed that nuclei from red blood cells and cells in liver (an erythropoietic organ) contain DNase gamma-like activities (molecular mass of 38 and 36 kDa) indicated by their biochemical features (internucleosomal DNA cleavage, requirement of Ca2+ and Mg2+, and sensitivity to Zn2+).	Zinc	341-345	deoxyribonuclease 1 like 3	Homo sapiens	158-169
9264806-0	1997	[Levels of Cu, Zn, Se and their relation to levels of ceruloplasmin and the activity of antioxidative enzymes].	Zinc	15-17	ceruloplasmin	Homo sapiens	54-67
9049956-1	1997	The aim of the study was to determine whether the induction of HSP70 by Zn2+ is able to protect the small bowel of rats against ischemia.	Zinc	72-76	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	63-68
9049956-7	1997	Zn2+ injection, the small bowel expressed increased HSP70 tissue levels.	Zinc	0-4	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	52-57
9049956-9	1997	In conclusion, this study proves that Zn2+ is inducing HSP70 in the small bowel in vivo and hereby able to protect the small bowel against ischemia.	Zinc	38-42	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	55-60
8947044-2	1996	Here, an attempt is made to probe helix-helix interactions systematically in the NK-1 receptor by engineering of bis-His Zn(II) sites.	Zinc	121-123	tachykinin receptor 1	Homo sapiens	81-94
8858095-0	1996	Novel difference in IF1 reactivity to Zn2+ in rabbit versus rat cardiomyocytes, mitochondria, and submitochondrial particles.	Zinc	38-42	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	20-23
8858095-1	1996	Zn2+ has a paradoxical effect on IF1-ATPase interaction in cardiac muscle mitochondria in so-called slow heart-rate mammalian species like rabbit.	Zinc	0-4	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	33-36
8858095-6	1996	While our earlier study suggested that there are two kinds of IF1-ATPase interaction, a docking interaction and an ATPase inhibitory interaction with Zn2+ promoting docking and interfering with inhibition, it did not yield information on whether Zn2+ interacted primarily with IF1, with the ATPase, or with both.	Zinc	150-154	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	62-65
8858095-7	1996	In the present study we show that, in contrast to its effects in rabbit cardiomyocytes, mitochondria, and SMP in which Zn2+ fully blocked IF1-mediated ATPase inhibition, Zn2+ actually enhanced ATPase inhibition in rat cardiomyocytes, although the extent of this effect was limited by the low level of IF1 in rat cardiomyocytes.	Zinc	119-123	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	138-141
17298084-7	2007	Zn2+ also strongly inhibits Erv2p when assayed using tris(2-carboxyethyl)phosphine (TCEP) as the reducing substrate of the oxidase.	Zinc	0-4	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	28-33
17275103-2	2007	AMPA receptors lacking GluR2 subunits are permeable to Ca(2+) and Zn(2+).	Zinc	66-68	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	23-28
8889153-3	1996	Ca2+ currents through this channel, from either MV or annexin V liposomes, are blocked by Zn2+, as is Ca2+ uptake by MV incubated in synthetic cartilage lymph.	Zinc	90-94	annexin A5	Homo sapiens	54-63
8889153-6	1996	In the distinctive effects of ATP, GTP, and Zn2+ on the Ca2+ channel activity observed in both the MV and the liposome systems, the common factor was the presence of annexin V.	Zinc	44-48	annexin A5	Homo sapiens	166-175
8883388-7	1996	Partially purified LeFTase requires Zn2+ and Mg2+ for enzymatic activity and has an apparent molecular mass of 100 kD Immunoprecipitation experiments using anti-alpha LeFTB antibodies confirmed that LeFTB is a component of LeFTase but not of tomato geranylgeranyl-protein transferase 1.	Zinc	36-40	farnesyl protein transferase subunit B	Solanum lycopersicum	199-204
8710882-7	1996	The cleavage of lamin A by Mch2 alpha and by S/M extracts was inhibited by millimolar concentrations of Zn2+, which had a minimal effect on cleavage of poly (ADP-ribose) polymerase by CPP32 and by S/M extracts.	Zinc	104-108	melanin concentrating hormone receptor 2	Homo sapiens	27-31
8631882-7	1996	With Zn2+ stimulation of furin expression, the messages of PC2, PC3, and chromogranin A decreased, and the processing of proinsulin to mature insulin became less efficient.	Zinc	5-9	minisatellite 6 hypermutable 3	Mus musculus	59-62
16979290-7	2007	Strain SA2 grew with metalloid, halogenated and non-metal ions present in phosphogypsum and with added high concentrations of heavy metals (125ppm Zn and 100ppm Ni, W, Li and Al).	Zinc	147-149	stromal antigen 2	Homo sapiens	7-10
17049729-2	2007	In this study the competitive sorption and desorption of Cd, Cr, Cu, Ni, Pb and Zn by humified organic matter, Fe and Mn oxides, kaolinite, vermiculite and mica were investigated.	Zinc	80-82	MHC class I polypeptide-related sequence A	Homo sapiens	156-160
8670096-0	1996	Evidence for a Zn(2+)-binding site in human serum butyrylcholinesterase.	Zinc	15-21	butyrylcholinesterase	Homo sapiens	50-71
8670096-1	1996	Purified human serum butyrylcholinesterase after treatment with either of the metal chelators EDTA or NaCN was able to bind to a Zn(2+)-chelate-Sepharose affinity column and was eluted from the column by EDTA or imidazole.	Zinc	129-135	butyrylcholinesterase	Homo sapiens	21-42
8670096-8	1996	These results suggest the presence of a Zn(2+)-binding site on human serum butyrylcholinesterase and the involvement of histidine residues in the metal binding.	Zinc	40-46	butyrylcholinesterase	Homo sapiens	75-96
8670096-9	1996	The presence in human serum butyrylcholinesterase of a sequence HXXE...H found in many known Zn(2+)-containing enzymes supports these findings.	Zinc	93-99	butyrylcholinesterase	Homo sapiens	28-49
17359251-2	2007	Two Zn-rich hexagonal close-packed structure phases eta and epsilon phases were distinguished using predetermined lattice parameters of the phases.	Zinc	4-6	endothelin receptor type A	Homo sapiens	52-55
8617216-7	1996	As demonstrated by atomic absorption and extended X-ray absorption fine structure spectroscopy (EXAFS), the 90 amino acid cysteine-rich region of DnaJ contains two Zn atoms tetrahedrally coordinated to four cysteine residues, resembling their arrangement in the C4 Zn binding domains of certain DNA binding proteins.	Zinc	164-166	DnaJ	Escherichia coli	146-150
8617216-7	1996	As demonstrated by atomic absorption and extended X-ray absorption fine structure spectroscopy (EXAFS), the 90 amino acid cysteine-rich region of DnaJ contains two Zn atoms tetrahedrally coordinated to four cysteine residues, resembling their arrangement in the C4 Zn binding domains of certain DNA binding proteins.	Zinc	265-267	DnaJ	Escherichia coli	146-150
17160583-1	2007	Using the whole-cell patch-clamp technique, we investigated the influence of extracellular pH and zinc ions (Zn(2+)) on the steady-state inactivation of Kv1.3 channels expressed in human lymphocytes.	Zinc	109-111	potassium voltage-gated channel subfamily A member 3	Homo sapiens	153-158
17885920-0	2007	Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.	Zinc	13-17	G protein-coupled receptor 39	Rattus norvegicus	46-51
8960349-9	1996	These observations, in accordance with the finding that the cysteine-rich region binds to Ca2+, Zn2+, and calmodulin, suggest an active involvement of dystrophin in transducing signals across muscle sarcolemma.	Zinc	96-100	dystrophin	Homo sapiens	151-161
17885920-5	2007	In this fashion, Zn2+ ion was identified as an agonist of GPR39, though no peptidergic molecules were found.	Zinc	17-21	G protein-coupled receptor 39	Rattus norvegicus	58-63
17885920-6	2007	The calcium-mobilizing activity of Zn2+ was not abolished by pertussis toxin but was by a phospholipase C (PLC) inhibitor, U73122, indicating that the activity of GPR39 is mediated through the Gqalpha -PLC pathway.	Zinc	35-39	G protein-coupled receptor 39	Rattus norvegicus	163-168
9084669-7	1996	Inclusion of phosphatidylethanolamine (PE) or sphingomyelin (SM) with PS, or Mg2+ or Zn2+ with Ca2+, strongly inhibited activity; incorporation of annexin V increased SNAC activity.	Zinc	85-89	annexin A5	Homo sapiens	147-156
17885920-7	2007	In addition, Zn2+ also activated mouse and rat GPR39, showing that the function of GPR39 as a Zn2+ receptor is conserved across species.	Zinc	13-17	G protein-coupled receptor 39	Rattus norvegicus	47-52
17885920-7	2007	In addition, Zn2+ also activated mouse and rat GPR39, showing that the function of GPR39 as a Zn2+ receptor is conserved across species.	Zinc	13-17	G protein-coupled receptor 39	Rattus norvegicus	83-88
17335495-4	2007	* In the hma2, hma4 double mutant, which is deficient in root to shoot Zn translocation, Zinpyr-1 fluorescence was low in the xylem and high in the adjacent pericycle cells in which HMA2 and HMA4 are specifically expressed in a wild type.	Zinc	71-73	heavy metal atpase 4	Arabidopsis thaliana	15-19
9196075-2	1996	These Zn2(+)- and Ca2(+)-dependent MMPs degrade components of the extracellular matrix (ECM), and precise regulation of their expression is crucial in many normal processes.	Zinc	6-12	matrix metallopeptidase 7	Homo sapiens	35-39
7476340-1	1995	Zinc (Zn) deficiency can result in severe growth retardation in mammals, and in a number of animal model systems it leads to low circulating insulin-like growth factor-I (IGF-I) concentrations.	Zinc	6-8	insulin-like growth factor 1	Rattus norvegicus	141-169
7476340-1	1995	Zinc (Zn) deficiency can result in severe growth retardation in mammals, and in a number of animal model systems it leads to low circulating insulin-like growth factor-I (IGF-I) concentrations.	Zinc	6-8	insulin-like growth factor 1	Rattus norvegicus	171-176
7476340-2	1995	Using a weanling male rat model and a number of feeding schemes, we show that in addition to lower circulating IGF-I concentrations, Zn deficiency leads to alterations in the distribution of serum IGF-binding proteins (IGFBPs).	Zinc	133-135	insulin-like growth factor binding protein 1	Rattus norvegicus	219-225
7476340-3	1995	Serum from Zn-deficient animals labeled in vitro with [125I]IGF-I displayed three peaks of tracer activity: 150 kd (IGFBP-3), 37 kd (IGFBP-2 and -1), and 8 kd (free [125I]IGF-I).	Zinc	11-13	insulin-like growth factor 1	Rattus norvegicus	60-65
7476340-3	1995	Serum from Zn-deficient animals labeled in vitro with [125I]IGF-I displayed three peaks of tracer activity: 150 kd (IGFBP-3), 37 kd (IGFBP-2 and -1), and 8 kd (free [125I]IGF-I).	Zinc	11-13	insulin-like growth factor binding protein 3	Rattus norvegicus	116-123
7476340-3	1995	Serum from Zn-deficient animals labeled in vitro with [125I]IGF-I displayed three peaks of tracer activity: 150 kd (IGFBP-3), 37 kd (IGFBP-2 and -1), and 8 kd (free [125I]IGF-I).	Zinc	11-13	insulin-like growth factor 1	Rattus norvegicus	171-176
7544912-4	1995	The occurrence of alpha 2M/pMBP-28 complexes was further indicated by crossed immunoelectrophoresis and by use of an anti-alpha 2M affinity column and chelating Sepharose loaded with Zn2+.	Zinc	183-187	alpha-2-macroglobulin	Homo sapiens	18-26
7607305-2	1995	In sub-line cells accommodated to intermediate metal concentrations (100 microM Zn2+; 1-20 microM Cd2+) evidence suggested that the increase in the capacity for isoMT synthesis is brought about by an increased binding activity of the nuclear transcription factors MTF-1 and Sp1.	Zinc	80-84	metal regulatory transcription factor 1	Oryctolagus cuniculus	264-269
7860645-2	1995	We found that in several types of cultured cells and in mice, Zn++ caused marked accumulation of c-fos mRNA and that of another labile mRNA, that encoding the tristetraprolin (TTP) protein.	Zinc	62-66	FBJ osteosarcoma oncogene	Mus musculus	97-102
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	31-35	FBJ osteosarcoma oncogene	Mus musculus	84-89
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	31-35	FBJ osteosarcoma oncogene	Mus musculus	202-207
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	160-164	FBJ osteosarcoma oncogene	Mus musculus	84-89
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	160-164	FBJ osteosarcoma oncogene	Mus musculus	202-207
7860645-6	1995	Zn++ was unable to inhibit the breakdown of TTP and c-fos mRNA in vitro; however, extracts from cells exposed to Zn++ were less able to cause the breakdown of TTP and c-fos mRNAs than were extracts from control cells, again suggesting that Zn++ indirectly affects mRNA stability through inhibition of protein synthesis.	Zinc	113-117	FBJ osteosarcoma oncogene	Mus musculus	167-172
7860645-6	1995	Zn++ was unable to inhibit the breakdown of TTP and c-fos mRNA in vitro; however, extracts from cells exposed to Zn++ were less able to cause the breakdown of TTP and c-fos mRNAs than were extracts from control cells, again suggesting that Zn++ indirectly affects mRNA stability through inhibition of protein synthesis.	Zinc	113-117	FBJ osteosarcoma oncogene	Mus musculus	167-172
7862134-4	1995	Thus, the binuclear Zn clusters of GAL4, the helix-loop-helix/basic domains of USF, and the rel domain of NF-kappa B all participated in cooperative nucleosome binding, illustrating that this effect is not restricted to a particular DNA-binding domain.	Zinc	20-22	upstream transcription factor 1	Homo sapiens	79-82
17021797-5	2007	The Zn(2+)-stimulated [Ca(2+)](i) increase was inhibited by thapsigargin (200 nM), the IP(3) receptor antagonist 2-aminoethoxydiphenyl borate (10 microM) and removal of bath Ca(2+).	Zinc	4-10	inositol 1,4,5-triphosphate receptor 3	Mus musculus	87-101
16962233-9	2006	Of the two metal ions examined, Cd2+ was found to form the most stable HA complexes, followed by Zn.	Zinc	97-99	T-cell surface antigen CD2	Meleagris gallopavo	32-35
17008722-6	2006	Focusing on residues near the extracellular ends of hSERT TMHs I and III, we engineered potential Zn2+-binding sites between V102 or W103 (TMH I) and I179-L184 (TMH III).	Zinc	98-102	LHFPL tetraspan subfamily member 5	Homo sapiens	58-62
17008722-10	2006	We propose that the increased sensitivity to Zn2+ confirms the proximity and the orientation of TMHs I and III in the membrane.	Zinc	45-49	LHFPL tetraspan subfamily member 5	Homo sapiens	96-100
16839579-3	2006	ZN-1 and ZN-2 inhibited the proliferation of ERalpha and ERbeta positive (MCF-7) and negative (MCF-10A) breast cells, further ruling out direct binding to ER in the mechanism of action of these compounds.	Zinc	9-13	estrogen receptor 2	Homo sapiens	57-63
16839579-8	2006	Both ZN-1 and ZN-2 blocked estradiol stimulation of c-Myc and cyclin D1 gene expression in MCF-7 cells, two events that are clearly coupled to cell cycle progression.	Zinc	14-18	cyclin D1	Homo sapiens	62-71
16714279-8	2006	Comparisons with other mammalian ZFP100 orthologs show that the central Zn fingers sufficient for in vivo activity are most highly conserved, whereas the number and sequence of the Zn fingers in the N- and C-terminal domains vary.	Zinc	72-74	zinc finger protein 473	Homo sapiens	33-39
8535348-5	1995	In patients with CI a significant correlation was found between low levels in serum Zn, on the one hand, and serum cholinesterase and proteinemia, on the other hand.	Zinc	84-86	butyrylcholinesterase	Homo sapiens	115-129
8066125-9	1994	Moreover, NB1RGB cells in which the MT content was elevated by dexamethasone (1 microM) or Zn2+ (7 micrograms/mL) treatment were more resistant to UVB irradiation than nontreated ones.	Zinc	91-95	CD177 molecule	Homo sapiens	10-13
8208612-5	1994	HEPR does not contain the carboxyl-terminus leucine zipper motif identified in REPR but contains consensus phosphorylation sites as well as the conserved histidine and both cysteine residues identified as a Zn2+ binding motif in other cytidine deaminases.	Zinc	207-211	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Homo sapiens	0-4
8195040-13	1994	These findings support the hypothesis that a preexisting MRF must complex with Zn to initiate increased transcription for MT.	Zinc	79-81	myelin regulatory factor	Homo sapiens	57-60
16714279-8	2006	Comparisons with other mammalian ZFP100 orthologs show that the central Zn fingers sufficient for in vivo activity are most highly conserved, whereas the number and sequence of the Zn fingers in the N- and C-terminal domains vary.	Zinc	181-183	zinc finger protein 473	Homo sapiens	33-39
16434969-3	2006	In this study, we further characterized the PKC-delta dependent signaling pathways involved in these tumor suppressor actions in Caco-2 cells overexpressing PKC-delta using a Zn2+ inducible expression vector.	Zinc	175-179	protein kinase C delta	Homo sapiens	44-53
16434969-3	2006	In this study, we further characterized the PKC-delta dependent signaling pathways involved in these tumor suppressor actions in Caco-2 cells overexpressing PKC-delta using a Zn2+ inducible expression vector.	Zinc	175-179	protein kinase C delta	Homo sapiens	157-166
16376920-0	2006	Photophysics and charge dynamics of Q-PbS based mixed ZnS/PbS and PbS/ZnS semiconductor nanoparticles.	Zinc	54-57	cholinergic receptor muscarinic 3	Homo sapiens	38-41
16376920-0	2006	Photophysics and charge dynamics of Q-PbS based mixed ZnS/PbS and PbS/ZnS semiconductor nanoparticles.	Zinc	70-73	cholinergic receptor muscarinic 3	Homo sapiens	38-41
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	15-18	cholinergic receptor muscarinic 3	Homo sapiens	60-63
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	15-18	cholinergic receptor muscarinic 3	Homo sapiens	60-63
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	23-26
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	60-63
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	60-63
8205117-7	1994	ECE, once inactivated by EDTA or 8-MQ, was reactivated by the addition of divalent cations such as Zn2+ and Mn2+.	Zinc	99-103	endothelin converting enzyme 1	Homo sapiens	0-3
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	23-26
8205118-9	1994	Taking into consideration the in vitro results, more selective chelating activity of the compounds towards Zn2+ rather than Ca2+ and Mg2+ may contribute to the inhibition of big ET-1-induced responses in vivo.	Zinc	107-111	endothelin 1	Mus musculus	178-182
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	60-63
16376920-1	2006	The surface of ZnS and PbS has been modified by interfacing PbS on ZnS and ZnS on PbS nanoparticles.	Zinc	67-70	cholinergic receptor muscarinic 3	Homo sapiens	60-63
16376920-2	2006	This produced core-shell nanocomposites ZnS/PbS and PbS/ZnS with tunable electronic properties.	Zinc	56-59	cholinergic receptor muscarinic 3	Homo sapiens	52-55
16376920-6	2006	At 1.5 x 10(-4) mol dm(-3) Pb2+ an interfacial relaxation of charge from ZnS to PbS phase could be observed in subnanosecond time domain.	Zinc	73-76	cholinergic receptor muscarinic 3	Homo sapiens	80-83
16376920-8	2006	Composite PbS/ZnS particles are produced at high [ZnS] only.	Zinc	50-53	cholinergic receptor muscarinic 3	Homo sapiens	10-13
16585064-9	2006	The enzymatic activity of ADAMTS-7 requires the presence of Zn2+ and appropriate pH (7.5-9.5), and the concentration of ADAMTS-7 in cartilage and synovium of patients with rheumatoid arthritis is significantly increased as compared to normal cartilage and synovium.	Zinc	60-64	ADAM metallopeptidase with thrombospondin type 1 motif 7	Homo sapiens	26-34
16298534-5	2006	Two parameterizations are obtained, then tested and compared through molecular dynamics simulations of two small, homologous proteins in explicit solvent: Protein Kinase C and the Cysteine Rich Domain (CRD) of Raf, which have two Cys3His-Zn2+ groups each.	Zinc	238-242	zinc fingers and homeoboxes 2	Homo sapiens	210-213
16023209-11	2006	As suggested by sequence homology, SEI requires Zn2+ for strong binding to DR1, which goes undetected in the presence of EDTA.	Zinc	48-52	down-regulator of transcription 1	Mus musculus	75-78
16098472-1	2005	M 3 A oligopeptidases from Escherichia coli, with hydrolytic properties similar to Zn-dependent mammalian thimet oligopeptidase (EP 24.15) and neurolysin (EP 24.16), were studied aiming at identification of comparative enzyme and substrate specificity, hydrolytic products, and susceptibility to inhibitors.	Zinc	83-85	thimet oligopeptidase 1	Homo sapiens	106-127
8288949-4	1994	On the other hand, we show that ADP and Zn2+ exert a cooperative effect on the phosphorylation of P-47 protein (pleckstrin), a substrate of protein kinase C in platelets.	Zinc	40-44	pleckstrin	Homo sapiens	112-122
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	212-214	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	108-114
8226932-3	1993	Harvesting the fibroblasts in medium containing orthovanadate and Zn2+ gave up to 3-fold higher PAP-2 activities when measured in the absence, but not in the presence, of Triton X-100.	Zinc	66-70	regenerating islet-derived 3 alpha	Rattus norvegicus	96-101
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	212-214	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	230-244
8408004-0	1993	Intrinsic stoichiometric equilibrium constants for the binding of zinc(II) and copper(II) to the high affinity site of serum albumin.	Zinc	66-74	albumin	Bos taurus	119-132
8408004-1	1993	Intrinsic stoichiometric equilibrium constants were determined for zinc(II) and copper(II) binding to bovine and human serum albumin.	Zinc	67-75	albumin	Bos taurus	119-132
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	212-214	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	246-251
8408004-7	1993	The log10K for bovine serum albumin were calculated to be 7.28 for Zn(II) and 11.12 for Cu(II).	Zinc	67-73	albumin	Bos taurus	22-35
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	212-214	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	261-267
8408004-8	1993	Those for human serum albumin were determined to be 7.53 and 11.18 for Zn(II) and Cu(II), respectively.	Zinc	71-77	albumin	Bos taurus	16-29
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	287-289	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	108-114
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	287-289	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	230-244
8265567-6	1993	This leads us to propose an alternative model, in which HCAII hydrates HCN to form an OH-/HCN complex coordinated to the Zn ion.	Zinc	121-123	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
8265567-6	1993	This leads us to propose an alternative model, in which HCAII hydrates HCN to form an OH-/HCN complex coordinated to the Zn ion.	Zinc	121-123	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	90-93
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	287-289	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	246-251
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	287-289	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	261-267
16093311-7	2005	These results implicate GluR2-lacking AMPA receptors in the ischemia-induced rise in free Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unproven.	Zinc	90-92	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	24-29
16093311-7	2005	These results implicate GluR2-lacking AMPA receptors in the ischemia-induced rise in free Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unproven.	Zinc	175-177	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	24-29
16852161-1	2005	The hydrogen electrode reaction involving hydride ion, H-, at a Zn electrode is investigated in a molten LiCl-KCl-LiH system at 673 K. The charge-transfer resistances were measured by electrochemical impedance spectroscopy in the overpotential region of 0.10 &lt; or = eta &lt; or = 0.35 V and over the H- concentrations of 1.5 x 10(-4) &lt; or = C(H)- &lt; or = 1.2 x 10(-3) mol cm(-3).	Zinc	64-66	endothelin receptor type A	Homo sapiens	269-272
8503893-2	1993	The results showed that, whereas in parental cells MT concentration was low and composed nearly exclusively of MT-2a and MT-1a, all four isoMTs increased massively in abundance when the cells were exposed to toxic concentrations of Zn(II) or Cd(II), the relative increase being largest in the two minor isoforms MT-2d and MT-2e.	Zinc	232-238	metallothionein-2D	Oryctolagus cuniculus	312-317
8416947-3	1993	The NMDA receptor is distinct from other glutamate receptor channels because of its high Ca2+ permeability and inhibition by selective cationic channel blockers such as Mg2+, Zn2+, and MK-801.	Zinc	175-179	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	4-17
15634741-6	2005	Finally, reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import, which may reflect the unique requirement for Zn(2+) of this highly specialized cell type and thus provides a physiological explanation for the restricted tissue distribution of this Zn(2+) importer.	Zinc	216-218	solute carrier family 39 member 3	Homo sapiens	31-35
7515282-4	1993	TrpRS are Zn(2+)-dependent, dimeric, class I aminoacyl-tRNA synthetases with known amino acid sequence for four different mammalian orders.	Zinc	10-12	tryptophanyl tRNA synthetase 2, mitochondrial	Homo sapiens	0-5
15820896-4	2005	Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center.	Zinc	95-99	DNA polymerase iota	Homo sapiens	44-48
15826377-7	2005	In addition, we propose a mechanism for PGN hydrolysis by Zn2+-containing catalytic PGRPs.	Zinc	58-62	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	40-43
8382811-7	1993	In addition, metal ions inhibited NT binding and the contractile action of NT with the same order of potency (Hg++ &gt; Zn++ &gt; Cu++ &gt; Mn++ &gt; Mg++ &gt; Li++).	Zinc	120-124	neurotensin/neuromedin N	Cavia porcellus	75-77
16240673-7	2005	As for Fe, the Zn isotopic composition exhibited a tendency toward lower levels of fractionation in the blood of subjects with hereditary hemochromatosis with homozygous mutation (C282Y/C282Y) of the HFE gene.	Zinc	15-17	homeostatic iron regulator	Homo sapiens	200-203
1279483-5	1992	This selectivity of La3+ toward the subtypes of GABAA receptors contrasts to that of Zn2+ which inhibits the currents in the alpha 1 beta 2, but not in the alpha 1 beta 2 gamma 2 subtype (Neuron, 5: (1990) 781-788).	Zinc	85-89	adrenoceptor alpha 1D	Homo sapiens	125-132
1279483-5	1992	This selectivity of La3+ toward the subtypes of GABAA receptors contrasts to that of Zn2+ which inhibits the currents in the alpha 1 beta 2, but not in the alpha 1 beta 2 gamma 2 subtype (Neuron, 5: (1990) 781-788).	Zinc	85-89	adrenoceptor alpha 1D	Homo sapiens	156-178
16240673-8	2005	The results therefore suggest that both Fe and Zn isotopic signatures in whole blood, at least to some extent, reflect polymorphisms in the HFE gene.	Zinc	47-49	homeostatic iron regulator	Homo sapiens	140-143
15964699-3	2005	However, in the presence of Zn(2+), the potentiating effect of Tat was much more pronounced, indicating an additional Zn(2+)-related effect on NMDA receptors.	Zinc	28-30	tyrosine aminotransferase	Homo sapiens	63-66
15964699-3	2005	However, in the presence of Zn(2+), the potentiating effect of Tat was much more pronounced, indicating an additional Zn(2+)-related effect on NMDA receptors.	Zinc	28-34	tyrosine aminotransferase	Homo sapiens	63-66
15964699-4	2005	Consistently, Tat potentiated currents of the particularly Zn(2+)-sensitive NR1/NR2A NMDA receptor with a higher efficacy, whereas currents from a Zn(2+)-insensitive mutant were only marginally augmented.	Zinc	59-61	tyrosine aminotransferase	Homo sapiens	14-17
1497654-0	1992	Low-affinity Ca(2+)-binding sites versus Zn(2+)-binding sites in histidine-rich Ca(2+)-binding protein of skeletal muscle sarcoplasmic reticulum.	Zinc	41-47	sarcoplasmic reticulum histidine-rich calcium-binding protein	Oryctolagus cuniculus	65-102
1497654-4	1992	In contrast to Ca(2+)-binding protein calsequestrin not having detectable 65Zn-binding sites, HRC protein bound selectively to immobilized Zn2+ on IDA-agarose affinity columns.	Zinc	139-143	sarcoplasmic reticulum histidine-rich calcium-binding protein	Oryctolagus cuniculus	94-97
15964699-8	2005	Similar to tricine, Tat enhanced NMDA-mediated neurotoxicity in the presence of neuroprotective Zn(2+) concentrations.	Zinc	96-102	tyrosine aminotransferase	Homo sapiens	20-23
15142040-8	2004	Cox17 binds non-co-operatively two Zn2+ ions, but does not bind Ag+ ions, which highlights its extremely high metal-binding specificity.	Zinc	35-39	copper metallochaperone COX17	Saccharomyces cerevisiae S288C	0-5
15184059-2	2004	An arl1 Delta ccz1 Delta double mutant was viable but grew slowly, was more sensitive to caffeine, Ca(2+), Zn(2+), and hygromycin B than either single mutant, and had a more severe vacuolar protein sorting phenotype.	Zinc	107-109	Arf family GTPase ARL1	Saccharomyces cerevisiae S288C	3-7
1314899-0	1992	NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae.	Zinc	73-75	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	0-4
1314899-5	1992	However, the NAM7 protein contains several motifs typical for proteins interacting with nucleic acids: (1) five motifs diagnostic for a superfamily of helicases appear in the same order and with similar distances; (2) the N-terminal portion possesses potential Zn-ligand structures belonging to the C chi superfamily.	Zinc	261-263	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	13-17
1772874-15	1991	The Zn-deficient animals showed a more pronounced growth inhibition than that seen during Mg deficiency and after 17 d on Zn-deficient fodder s-IGF-1 was reduced by 83%.	Zinc	4-6	insulin-like growth factor 1	Rattus norvegicus	144-149
1772874-15	1991	The Zn-deficient animals showed a more pronounced growth inhibition than that seen during Mg deficiency and after 17 d on Zn-deficient fodder s-IGF-1 was reduced by 83%.	Zinc	122-124	insulin-like growth factor 1	Rattus norvegicus	144-149
1772874-16	1991	Following repletion with Zn, s-Zn was normalized and s-IGF-1 had increased by 194% (P less than 0.05) after 3 d. s-IGF-1, however, was not normalized until after 2.5 weeks of repletion.	Zinc	25-27	insulin-like growth factor 1	Rattus norvegicus	55-60
15169950-4	2004	In the presence of physiological levels (&lt;1 mM) of Zn(2+) and other thiophilic divalent cations such as Cd(2+) and Hg(2+), PDI forms a stable dimer that aggregates into much larger oligomeric forms with time.	Zinc	54-56	prolyl 4-hydroxylase subunit beta	Homo sapiens	126-129
15169950-6	2004	Oligomerization involves the interaction of Zn(2+) with the cysteines of PDI.	Zinc	44-46	prolyl 4-hydroxylase subunit beta	Homo sapiens	73-76
15169950-10	2004	The dimer incorporates two atoms of Zn(2+) and exhibits 50% of the isomerase activity of PDI.	Zinc	36-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	89-92
15169950-12	2004	Because of a very high concentration of PDI in the ER, its interaction with divalent ions could play a role in regulating the effective concentration of these metal ions, protecting against metal toxicity, or affecting the activity of other (ER) proteins that use Zn(2+) as a cofactor.	Zinc	264-266	prolyl 4-hydroxylase subunit beta	Homo sapiens	40-43
14727091-6	2004	The Zn(2+)-chelating activity of these siderophores correlated with the inhibition of MMP-2 activity.	Zinc	4-10	matrix metallopeptidase 2	Homo sapiens	86-91
1658609-9	1991	The results are consistent with a model in which a Zn-sensitive modulatory site exerts negative allosteric control over GABA receptor function.	Zinc	51-53	GABA type A receptor-associated protein	Homo sapiens	120-133
1888739-12	1991	Binding of Zn2+ to the apo form of alpha-lactalbumin does not result in significant backbone conformational changes, suggesting a rigid Zn(2+)-binding site.	Zinc	11-15	lactalbumin alpha	Bos taurus	35-52
14727091-7	2004	Therefore, it is considered that siderophores such as pyoverdines inhibit MMP-2 activity by chelating Zn(2+) on the active site of MMP-2.	Zinc	102-108	matrix metallopeptidase 2	Homo sapiens	74-79
14727091-7	2004	Therefore, it is considered that siderophores such as pyoverdines inhibit MMP-2 activity by chelating Zn(2+) on the active site of MMP-2.	Zinc	102-108	matrix metallopeptidase 2	Homo sapiens	131-136
15003446-4	2004	As E.coli GluRS, YadB possesses a Zn2+ located in the putative tRNA acceptor stem-binding domain.	Zinc	34-38	hypothetical protein	Escherichia coli	17-21
1661135-3	1991	Clone MI5 did not secrete detectable levels of IGF-II activity, as determined by radioimmunoassay of conditioned medium, but clone MI7 secreted high levels of IGF-II activity in a Zn2+ inducible fashion.	Zinc	180-184	insulin like growth factor 2	Homo sapiens	159-165
1661135-8	1991	The antiestrogens tamoxifen and 4-hydroxytamoxifen were found to enhance the growth stimulation resulting from Zn2+ induced IGF-II production in MI7 cells.	Zinc	111-115	insulin like growth factor 2	Homo sapiens	124-130
15013746-2	2004	Functional expression of AtHMA3 phenotypically complements the Cd/Pb-hypersensitive yeast strain Deltaycf1, but not the Zn-hypersensitive mutant Deltazrc1.	Zinc	120-122	heavy metal atpase 3	Arabidopsis thaliana	25-31
1850171-12	1991	Surprisingly, Cd2+, Co2+, Ni2+, and Zn2+, which caused a depression in hCG- and db-cAMP-stimulated T production, caused significant increases in HCHOL- and PREG-stimulated T production over untreated and similarly stimulated cultures.	Zinc	36-40	CD2 molecule	Homo sapiens	14-17
15306062-3	2004	This effect can be signally reduced by the precession technique, which we have used to collect extensive intensity data from the semicoherent, metastable eta-precipitate in the Al-Zn-Mg alloy system.	Zinc	180-182	endothelin receptor type A	Homo sapiens	144-147
1984413-8	1991	Incubating the cells with Zn2+ prior to assaying efflux in the absence of Zn2+ strongly inhibited the stimulation of 45Ca2+ efflux by Cd2+, pH 6, and the removal of external Na+ without affecting the stimulation of efflux by ATP.	Zinc	26-30	CD2 molecule	Homo sapiens	134-137
14685271-4	2004	We identified sur-7 by isolating a mutation that suppresses an activated ras allele, and showed that SUR-7 is a divergent member of the cation diffusion facilitator family of heavy metal ion transporters that is probably localized to the endoplosmic recticulum membrane and regulates cellular Zn(2+) concentrations.	Zinc	293-295	SUppressor of activated let-60 Ras	Caenorhabditis elegans	14-19
2254329-13	1990	Surface binding of Cd2+ to mesangial cells was suppressed by competing divalent ions following the order of the Irving-Williams series (Mn less than Co less than Ni less than Cu greater than Zn), although Zn2+ showed the greatest effect on internalization.	Zinc	191-193	CD2 molecule	Sus scrofa	19-22
2254329-13	1990	Surface binding of Cd2+ to mesangial cells was suppressed by competing divalent ions following the order of the Irving-Williams series (Mn less than Co less than Ni less than Cu greater than Zn), although Zn2+ showed the greatest effect on internalization.	Zinc	205-209	CD2 molecule	Sus scrofa	19-22
2254329-14	1990	In LLC-PK1 cells, Zn2+ and Cu2+ were both effective in decreasing Cd2+ uptake.	Zinc	18-22	CD2 molecule	Sus scrofa	66-69
14685271-4	2004	We identified sur-7 by isolating a mutation that suppresses an activated ras allele, and showed that SUR-7 is a divergent member of the cation diffusion facilitator family of heavy metal ion transporters that is probably localized to the endoplosmic recticulum membrane and regulates cellular Zn(2+) concentrations.	Zinc	293-295	SUppressor of activated let-60 Ras	Caenorhabditis elegans	101-106
14717702-7	2004	These are the first data demonstrating that GCH recognizes Mg-free GTP and requires Zn2+ for its catalytic activity.	Zinc	84-88	GTP cyclohydrolase 1	Homo sapiens	44-47
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	alpha-2-macroglobulin	Homo sapiens	71-79
1700994-3	1990	Characterization of optimal conditions for binding 125I IL-1 beta to H alpha 2M showed that H alpha 2M-IL-1 beta complex formation could be obtained over a pH range of 6.3 to 9 in the presence of some metal cations (i.e., Zn2+, Cd2+, Cu2+, Ni2+).	Zinc	222-226	alpha-2-macroglobulin	Homo sapiens	94-102
14622981-7	2003	These findings suggest that AA and SVCT2 mediate Zn-induced OPN and OCN expression and partly regulate Zn-induced osteoblastic differentiation.	Zinc	49-51	solute carrier family 23 member 2	Homo sapiens	35-40
14622981-7	2003	These findings suggest that AA and SVCT2 mediate Zn-induced OPN and OCN expression and partly regulate Zn-induced osteoblastic differentiation.	Zinc	103-105	solute carrier family 23 member 2	Homo sapiens	35-40
2085316-1	1990	The isozyme pattern of superoxide dismutase (SOD) in tomato consists of two Cu,Zn isozymes located, respectively, in the chloroplast and in the cytosol, as well as additional isozymes of the Mn or Fe SOD type.	Zinc	79-81	iron superoxide dismutase	Solanum lycopersicum	23-43
2085316-1	1990	The isozyme pattern of superoxide dismutase (SOD) in tomato consists of two Cu,Zn isozymes located, respectively, in the chloroplast and in the cytosol, as well as additional isozymes of the Mn or Fe SOD type.	Zinc	79-81	iron superoxide dismutase	Solanum lycopersicum	45-48
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor 1	Mus musculus	68-73
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor 1	Mus musculus	91-96
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor 2 receptor	Mus musculus	163-182
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor 2 receptor	Mus musculus	184-190
14566968-10	2003	Zn(2+) was active at physiological doses depressing IGF binding to IGFBP-5 and the IGF-2R at 15-20 microM.	Zinc	0-2	insulin-like growth factor 2 receptor	Mus musculus	83-89
2358072-5	1990	The data suggest that Ca2+ and Zn2+ might trigger the biological activity of calcyclin.	Zinc	31-35	S100 calcium binding protein A6 (calcyclin)	Mus musculus	77-86
12944405-7	2003	Released Zn2+ from 2-8 x 10(8) collagen-activated platelets/ml supported biotin-FXI binding to HUVEC monolayers, but platelet activation was not necessary to support biotin-PK binding to HUVECs.	Zinc	9-13	coagulation factor XI	Homo sapiens	80-83
32795642-9	2020	Mechanistic study applying human renal tubular epithelial cells (HK11) confirmed the role of Nrf2, as silencing Nrf2 expression abolished Zn supplementation protection against high sugar + high fat + low Zn-induced apoptosis and downregulation of beta-catenin expression.	Zinc	138-140	catenin beta 1	Homo sapiens	247-259
32795642-10	2020	All these results suggest that Nrf2 plays a key role in Zn protection against Type 2 diabetes induced renal apoptosis, which might be through Wnt/beta-catenin signaling pathway.	Zinc	56-58	catenin beta 1	Homo sapiens	146-158
12857921-7	2003	Defects in the CNBP-5 mutant could possibly be explained, in part, by restrictions of a set of required atom-atom interactions in the CNBP-5 Zn(2+) finger compared to mutant and wild-type Zn(2+) fingers in NC that support replication.	Zinc	141-143	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	15-19
34866297-5	2022	The primary DNAzyme self-cleaved the DNA chain with Zn2+ as cofactor, and produced the secondary DNAzyme; the secondary DNAzyme afterwards cleaved the EGR-1 mRNA, and thus downregulated the expression of target EGR-1 protein, achieving DNAzyme-based gene therapy.	Zinc	52-56	early growth response 1	Mus musculus	211-216
12857921-7	2003	Defects in the CNBP-5 mutant could possibly be explained, in part, by restrictions of a set of required atom-atom interactions in the CNBP-5 Zn(2+) finger compared to mutant and wild-type Zn(2+) fingers in NC that support replication.	Zinc	141-143	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	134-138
12857921-7	2003	Defects in the CNBP-5 mutant could possibly be explained, in part, by restrictions of a set of required atom-atom interactions in the CNBP-5 Zn(2+) finger compared to mutant and wild-type Zn(2+) fingers in NC that support replication.	Zinc	188-190	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	15-19
12748189-12	2003	The ATP-dependent DNA helicase activity of DinG requires divalent cations (Mg2+, Ca2+, and Mn2+) but is not observed in the presence of Zn2+.	Zinc	136-140	ring finger protein 2	Homo sapiens	43-47
12778114-4	2003	The high-resolution solution structure of the CITED2 TAD-p300 CH1 complex shows that the CITED2 TAD, like the HIF-1alpha C-TAD, folds on a helical, Zn2+-containing CH1 scaffold.	Zinc	148-152	E1A binding protein p300	Homo sapiens	57-61
12729761-6	2003	Metal-deficient apo SOD1 crystallizes with two dimers in the asymmetric unit and shows changes in the metal-binding sites and disorder in the Zn binding and electrostatic loops of one dimer, which is devoid of metals.	Zinc	142-144	superoxide dismutase [Cu-Zn]	Bos taurus	20-24
12568578-1	2003	This paper deals with the use of derivative potentiometric stripping analysis (dPSA) as a rapid and precise method to determine Cd(II), Cu(II), Pb(II), and Zn(II) levels in red and white wine samples from Sicily, Campania, and Tuscany and to investigate the possible connection between the content of these metals and the pesticide treatments used in vine-growing to control plant diseases and pests.	Zinc	156-162	Puromycin sensitive aminopeptidase	Drosophila melanogaster	79-83
12237343-7	2002	However, these modulators affected rP2X(1) receptors in subtly different ways-with increasing H(+) and Zn(2+) ion concentrations reducing agonist potency.	Zinc	103-105	purinergic receptor P2X 1	Rattus norvegicus	35-42
11940571-10	2002	In addition, they indicate a physiological role of Zn2+, because Zn2+ also facilitated transport reversal of DAT in rat striatal slices.	Zinc	51-55	solute carrier family 6 member 3	Rattus norvegicus	109-112
11940571-10	2002	In addition, they indicate a physiological role of Zn2+, because Zn2+ also facilitated transport reversal of DAT in rat striatal slices.	Zinc	65-69	solute carrier family 6 member 3	Rattus norvegicus	109-112
12044548-6	2002	Carbobenzoxy-Asp-1-yl-[(2,6-dichlorobenzoyl)oxy]methane (Z-Asp-CH(2)-DCB), a caspase family protease inhibitor, prevented ricin-induced increase in Zn(2+) probe fluorescence.	Zinc	148-150	nudix hydrolase 11	Homo sapiens	13-18
12065635-5	2002	Here we demonstrate that PSD-95 eliminates the Src-induced potentiation of NR1/NR2A channels expressed in oocytes and reduces the sensitivity of the channels to Zn(2+).	Zinc	161-163	discs large MAGUK scaffold protein 4	Homo sapiens	25-31
12007609-0	2002	Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+.	Zinc	147-151	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	17-54
11805091-6	2002	The dose-response curve for Zn(2+) inhibition was identical for AC1, AC5, and AC6 as well as for the C441R mutant of AC5 whose defect appears to be in one of the catalytic metal binding sites.	Zinc	28-30	adenylate cyclase 1	Mus musculus	64-67
11744691-7	2002	The lipoamide dehydrogenase reaction catalyzed by the purified pig heart enzyme is strongly inhibited by Zn(2+) (K(i) approximately 0.15 microm) in both directions.	Zinc	105-111	dihydrolipoamide dehydrogenase	Sus scrofa	4-27
11867606-4	2002	Based on metal coordination, conjugation of IFNbeta with DTPA-dextran resulted from simply mixing both substances in an aqueous solution containing Zn(2+).	Zinc	148-150	interferon beta 1	Homo sapiens	44-51
11897525-1	2002	BACKGROUND: Zinc (Zn) blocks caspase-3 activation in cardiac allografts and therefore may synergistically decrease apoptosis along with cyclosporine (CsA), which inhibits mitochondrial release of cytochrome c. Simultaneous treatment of rat recipients of heterotopic heart transplants with zinc chloride (ZnCl(2)) thus may allow lower doses of CsA for immunosuppression.	Zinc	18-20	caspase 3	Rattus norvegicus	29-38
12812047-5	2002	It is suggested that significantly elevated plasma nociceptin level is due to the inhibition of nociceptin-inactivating Zn-metallopeptidases (aminopeptidase N, endopeptidase 24.15) by the toxic copper levels, as it is known that changing the central Zn atom to Cu results in an approximately 50% inhibition in the activity of these enzymes.	Zinc	120-122	alanyl aminopeptidase, membrane	Homo sapiens	142-158
12812047-5	2002	It is suggested that significantly elevated plasma nociceptin level is due to the inhibition of nociceptin-inactivating Zn-metallopeptidases (aminopeptidase N, endopeptidase 24.15) by the toxic copper levels, as it is known that changing the central Zn atom to Cu results in an approximately 50% inhibition in the activity of these enzymes.	Zinc	120-122	thimet oligopeptidase 1	Homo sapiens	160-179
12238810-3	2002	Three major bands with gelatinolytic activity were detected at all periods and characterized as the latent and active forms of MMP-2 using their molecular weight and activity dependent on Zn++ and Ca++ ions as criteria.	Zinc	188-192	matrix metallopeptidase 2	Rattus norvegicus	127-132
11524427-1	2001	The human metalloregulatory transcription factor, metal-response element (MRE)-binding transcription factor-1 (MTF-1), contains six TFIIIA-type Cys(2)-His(2) motifs, each of which was projected to form well-structured betabetaalpha domains upon Zn(II) binding.	Zinc	245-247	metal regulatory transcription factor 1	Homo sapiens	50-109
11524427-1	2001	The human metalloregulatory transcription factor, metal-response element (MRE)-binding transcription factor-1 (MTF-1), contains six TFIIIA-type Cys(2)-His(2) motifs, each of which was projected to form well-structured betabetaalpha domains upon Zn(II) binding.	Zinc	245-247	metal regulatory transcription factor 1	Homo sapiens	111-116
11588099-13	2001	The divalent cation current block profile for ECaC1 is Pb(2+)=Cu(2+) &gt;Zn(2+) &gt;Co(2+) &gt;Fe(2+) with IC(50) values between 1 and approximately 10 microM.	Zinc	73-75	transient receptor potential cation channel subfamily V member 5	Homo sapiens	46-51
11516275-8	2001	Frameworks constructed from less symmetric tetrahedral SBUs have the Ga network of CaGa(2)O(4) as illustrated by Zn(2)(ATC).	Zinc	113-118	S100 calcium binding protein A8	Homo sapiens	83-87
11375951-9	2001	RESULTS: In the presence of Zn(2+), PKC-delta transfectants expressed a 4-fold increase in the protein and a 2-fold increase in activity of PKC-delta.	Zinc	28-30	protein kinase C delta	Homo sapiens	36-45
11375951-9	2001	RESULTS: In the presence of Zn(2+), PKC-delta transfectants expressed a 4-fold increase in the protein and a 2-fold increase in activity of PKC-delta.	Zinc	28-30	protein kinase C delta	Homo sapiens	140-149
11353088-1	2001	Zinc cluster proteins (or binuclear cluster proteins) possess zinc fingers of the Zn(II)2Cys6-type involved in DNA recognition as exemplified by the well-characterized protein Gal4p.	Zinc	82-84	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	176-181
34716655-2	2022	Density functional theory calculations illustrate that the Zn2+ can effectively modulate the electrical ordering of Znx Co1- x PS3 on the nanoscale: the reduced charge distribution emerging around the Zn ions can enhance the local built-in electric field, which will accelerate the ions migration rate by Coulomb forces and provide tempting opportunities for manipulating Li+ storage behavior.	Zinc	59-63	taste 2 receptor member 6 pseudogene	Homo sapiens	127-130
11327731-6	2001	The SHD1 and SHD2 of Slp3-a and Slp4 are separated by a putative Zn(2+)-binding sequence, whereas Slp1 and Slp2 lack such Zn(2+)-binding sequences and their SHD1 and SHD2 are linked together.	Zinc	65-71	SAC3 domain containing 1	Mus musculus	4-8
34716655-2	2022	Density functional theory calculations illustrate that the Zn2+ can effectively modulate the electrical ordering of Znx Co1- x PS3 on the nanoscale: the reduced charge distribution emerging around the Zn ions can enhance the local built-in electric field, which will accelerate the ions migration rate by Coulomb forces and provide tempting opportunities for manipulating Li+ storage behavior.	Zinc	201-203	taste 2 receptor member 6 pseudogene	Homo sapiens	127-130
11327731-6	2001	The SHD1 and SHD2 of Slp3-a and Slp4 are separated by a putative Zn(2+)-binding sequence, whereas Slp1 and Slp2 lack such Zn(2+)-binding sequences and their SHD1 and SHD2 are linked together.	Zinc	65-71	synaptotagmin-like 4	Mus musculus	32-36
34921583-5	2022	Therefore, the symmetrical CBL@Zn-CBL@Zn coin cell achieves a superior stability of 100 cycles with quite low overpotential (30 mv).	Zinc	38-40	Cbl proto-oncogene	Homo sapiens	27-30
34921583-5	2022	Therefore, the symmetrical CBL@Zn-CBL@Zn coin cell achieves a superior stability of 100 cycles with quite low overpotential (30 mv).	Zinc	38-40	Cbl proto-oncogene	Homo sapiens	34-37
11413003-4	2001	Here, we show that murine PrP(C) is rapidly endocytosed upon exposure of neuronal cells to physiologically relevant concentrations of Cu(2+) or Zn(2+), but not Mn(2+).	Zinc	144-146	prion protein	Mus musculus	26-32
34772165-11	2021	Comparison of ISM and VIM technologies in the removal efficiency of the Al-Zn alloy indicates a higher removal efficiency using the first technology, which, using the same conditions, achieves 80% of the removal efficiency of the component.	Zinc	75-77	vimentin	Homo sapiens	22-25
11243860-1	2001	High blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus were normalized by daily intraperitoneal (ip) administration of a zinc(II) complex, bis(maltolato)zinc(II) (Zn(Mal)(2)) with a Zn(O(4)) coordination mode, following the finding of strong in vitro insulinomimetic activity in isolated rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release.	Zinc	138-146	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	183-186
34858378-10	2021	The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05).	Zinc	148-150	apoptosis regulator BAX	Sus scrofa	94-120
34858378-10	2021	The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (p<0.05).	Zinc	148-150	apoptosis regulator BAX	Sus scrofa	122-125
11172020-3	2001	The basis of this phenomenon is Zn(2+)-induced multimerization of the KIR molecules as demonstrated by BIAcore, analytical ultracentrifugation, and chemical cross-linking experiments.	Zinc	32-38	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	70-73
34770852-1	2021	Carbonate MCO3 (M = Zn, Cd) can act as both Lewis acid and base to engage in a spodium bond with nitrogen-containing bases (HCN, NHCH2, and NH3) and a chalcogen bond with SeHX (X = F, Cl, OH, OCH3, NH2, and NHCH3), respectively.	Zinc	20-22	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	124-127
34686032-7	2021	Chelate form of Zn increased the activities of GST and GPOD in both Simonida and Divana.	Zinc	16-18	glutathione S-transferase kappa 1	Homo sapiens	47-50
11172020-4	2001	Zn(2+)-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the "natural killer (NK) cell immune synapse," observed at the site of contact between the NK cell and target cell.	Zinc	0-2	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	36-39
34528032-2	2021	An interface dipole was developed at the MOz/Zn interface, resulting in a decrease of the OER overpotential.	Zinc	45-47	lysine acetyltransferase 6A	Homo sapiens	41-44
11172020-4	2001	Zn(2+)-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the "natural killer (NK) cell immune synapse," observed at the site of contact between the NK cell and target cell.	Zinc	0-2	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	89-92
11162381-6	2001	Since the binding of Csk to Zn2+ is not affected by up to 200 mM NaCl, high ionic strength conditions were used in the purification procedure, minimizing nonspecific binding due to ionic interactions.	Zinc	28-32	C-terminal Src kinase	Homo sapiens	21-24
10965932-10	2000	In conclusion, our results demonstrate that the activity of antioxidant enzymes and plasma levels of Se, Zn and Mn levels were decreased in both homozygous and heterozygous subjects with leptin gene mutation.	Zinc	105-107	leptin	Homo sapiens	187-193
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	signal transducer and activator of transcription 3	Rattus norvegicus	163-169
34338604-9	2021	Our results show that Zn could prevent Cd-induced toxicity on MC3T3-E1 cells, probably through the restoration of Runx2, col alpha1, BSP, ALP and Oc and gene expression inhibited by Cd.	Zinc	22-24	runt related transcription factor 2	Mus musculus	114-119
34338604-9	2021	Our results show that Zn could prevent Cd-induced toxicity on MC3T3-E1 cells, probably through the restoration of Runx2, col alpha1, BSP, ALP and Oc and gene expression inhibited by Cd.	Zinc	22-24	bone gamma-carboxyglutamate protein 2	Mus musculus	146-148
34451746-6	2021	The objective of this research was to investigate the effects of leaf shape (curly leaf: CRL) on cottonseed B, Cu, Fe, Mn, Ni (nickel), and Zn in two near-isogenic cotton lines differing in leaf shape (DP 5690 wild-type with normal leaves and DP 5690 CRL).	Zinc	140-142	interleukin 31 receptor A	Homo sapiens	89-92
34451746-11	2021	The accumulation of Mn and Zn in seeds of DP 5690 CRL was higher than in DP 5690 wild-type and Uzbek CRL.	Zinc	27-29	interleukin 31 receptor A	Homo sapiens	50-53
34492884-3	2021	The results showed that Cd2+ and Pb2+ can form both inner- and outer-sphere complexes on Wyoming MMT, while Zn2+ only formed outer-sphere complex due to the stronger hydration interaction of Zn2+ than Cd2+ and Pb2+.	Zinc	191-195	CD2 molecule	Homo sapiens	24-27
34277682-10	2021	The zinc/metal storage protein metallothionein 3 (MT-3) was increased in SELENOP1-/- hippocampus relative to wildtype, possibly in response to an elevated Zn2+ content.	Zinc	155-159	metallothionein 3	Mus musculus	31-48
34277682-10	2021	The zinc/metal storage protein metallothionein 3 (MT-3) was increased in SELENOP1-/- hippocampus relative to wildtype, possibly in response to an elevated Zn2+ content.	Zinc	155-159	metallothionein 3	Mus musculus	50-54
34070833-6	2021	Based on a limited number of investigations, the reason for the lower levels of Zn in PCa is believed to be the dysregulation of Zn transporters (especially ZIP and ZnT family of proteins), metallothioneins (for storing and releasing Zn), and their regulators (e.g., Zn finger transcription factor RREB1).	Zinc	80-82	ras responsive element binding protein 1	Homo sapiens	298-303
34072023-5	2021	A Zn concentration was especially decreased in the blood of smoking AP patients with the AA genotype for SNP rs11640851 in the MT1A gene and the GC genotype for SNP rs10636 in MT2A, compared to non-smokers with AP, which was accompanied by an increase in the value of the Cu/Zn ratio.	Zinc	2-4	metallothionein 2A	Homo sapiens	176-180
35595137-6	2022	The absolute principle component score-multiple linear regression (APCS-MLR) and positive matrix factorization (PMF) model indicated that Zn (64.21%), Cd (51.58%), Cu (67.32%) and Ni (58.49%) in APCS-MLR model whereas Zn (49.5%), Cd (52.7%), Cu (57.4%) and Ni (44.6%) in PMF model were derived from traffic emission, agricultural activities, industrial source and mixed sources.	Zinc	138-140	amyloid P component, serum	Homo sapiens	195-199
35216977-5	2022	The EDS and FTIR results suggested that ion-exchange and complexation between CGB/Aged-CGB with Cd2+/Zn2+ played a dominant role in adsorption processes.	Zinc	101-105	CD2 molecule	Homo sapiens	96-99
35089513-10	2022	From the PCA diagram, we can observe that those sampling points in the positive direction of PC1 were expected to have a high concentration of Cu, Zn, As, Ni while having extremely little sand content.	Zinc	147-149	proprotein convertase subtilisin/kexin type 1	Homo sapiens	93-96
35189329-7	2022	This is supported by experiments showing 100microM Zn2+ addition restored (3H)-progesterone binding of the Q206R mutant to levels in WT mPRalpha and increased (3H)-progesterone binding to mPRgamma and AdipoR1 which have arginine residues in this region.	Zinc	51-55	S100 calcium binding protein A6 (calcyclin)	Mus musculus	136-144
35189329-7	2022	This is supported by experiments showing 100microM Zn2+ addition restored (3H)-progesterone binding of the Q206R mutant to levels in WT mPRalpha and increased (3H)-progesterone binding to mPRgamma and AdipoR1 which have arginine residues in this region.	Zinc	51-55	adiponectin receptor 1	Homo sapiens	201-208
35459748-5	2022	Elemental analysis measured stoichiometric quantities of Fe and Zn in yDbr1 purified following heterologous expression E. coli.	Zinc	64-66	RNA lariat debranching enzyme	Saccharomyces cerevisiae S288C	70-75
35559187-4	2022	The results indicated that CO2 coordination modes of eta1 (C) and eta2 (O, O) with Zn in ZnCl2/EA (1:4) TDESs are conceivable.	Zinc	83-85	secreted phosphoprotein 1	Homo sapiens	53-57
35319883-10	2022	Optical and single-crystal X-ray diffraction structural analysis of the host and the doped system supports our experimental data and confirms the structure-directing role played by Cd2+/Zn2+ centers.	Zinc	186-190	CD2 molecule	Homo sapiens	181-184
35349008-10	2022	Serum Zn was positively correlated with GAP-43 level among epileptic children (r = 0.381, p = 0.006).	Zinc	6-8	growth associated protein 43	Homo sapiens	40-46
35269490-9	2022	Only the Cd2+ current was able to cause the decay of channel activity, presumably as a result of Zn2+ to Cd2+ replacement.	Zinc	97-101	CD2 molecule	Homo sapiens	9-12
35212781-5	2022	The media pH is identified as the decisive factor which controls the dissolution of ZnS shells and also the Cd2+ release kinetics and final concentration.	Zinc	84-87	CD2 molecule	Homo sapiens	108-111
35107469-3	2022	DFT calculations provide important insights into the mechanism, particularly the unusual synergistic catalytic action of Zn2+, Br- and NR4+, which is the critical factor for the outstanding performance of Zn(betaine)2Br2.	Zinc	121-125	interleukin 13 receptor subunit alpha 1	Homo sapiens	135-138
35113349-8	2022	Compared with healthy people, MCI patients had higher whole blood Zn levels and lower Se levels, and Cu/Zn, Cu/Se, and Zn/Se were also significantly different.	Zinc	119-121	squalene epoxidase	Homo sapiens	122-124
35113349-9	2022	Binary logistic regression analysis showed that Zn, Cu/Se, and Zn/Se exposure in the third tertile was associated with an increased risk of MCI, while Se exposure in the third tertile was associated with a reduced risk of MCI.	Zinc	63-65	squalene epoxidase	Homo sapiens	66-68
35120684-9	2022	The principal component analysis result suggests that PC1 (Fe, Zn, Cu, and Ni) mainly comes from vehicular pollution, including tire wear and brake pad wear particles and corrosion of metallic components.	Zinc	63-65	proprotein convertase subtilisin/kexin type 1	Homo sapiens	54-57
35174244-4	2022	The mRNA expression levels of critical antioxidant enzymes such as SOD, CAT, and nuclear factor erythroid 2-related factor 2 (Nrf2) were increased by Zn in the jejunum (P < 0.05).	Zinc	150-152	nuclear factor erythroid 2-related factor 2	Anas platyrhynchos	81-124
35174244-4	2022	The mRNA expression levels of critical antioxidant enzymes such as SOD, CAT, and nuclear factor erythroid 2-related factor 2 (Nrf2) were increased by Zn in the jejunum (P < 0.05).	Zinc	150-152	nuclear factor erythroid 2-related factor 2	Anas platyrhynchos	126-130
35174244-5	2022	Supplementation with 60, 90, 120, and 150 mg/kg of Zn significantly reduced the diamine oxidase (DAO) activity in the serum (P < 0.05).	Zinc	51-53	DAO	Anas platyrhynchos	80-95
35174244-5	2022	Supplementation with 60, 90, 120, and 150 mg/kg of Zn significantly reduced the diamine oxidase (DAO) activity in the serum (P < 0.05).	Zinc	51-53	DAO	Anas platyrhynchos	97-100
35118363-3	2022	Using KCC2 truncated mutants, we show that KCC2 C-terminal domain is essential for membrane targeting and SNAP23-dependent upregulation of KCC2 activity triggered by activation of the Zn2+-sensitive receptor mZnR/GPR39 in HEK293 cells.	Zinc	184-188	G protein-coupled receptor 39	Homo sapiens	213-218
35109726-4	2021	Results showed that dietary Zn supplementation improved (p < 0.05) feed intake, BW, average daily gain, heart girth, body length, plasma growth hormone, insulin-like growth factor and thyroxin concentration; however, nutrient digestibility remained unaffected among the groups.	Zinc	28-30	insulin	Bos taurus	153-160
2611263-1	1989	Xenopus transcription factor IIIA (TFIIIA) contains two tightly bound intrinsic Zn2+ ions that are released through treatment with either p-(hydroxymercuri)benzenesulfonate (PMPS) or diethyl pyrocarbonate (DEP) as monitored by the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR).	Zinc	80-84	general transcription factor 3A L homeolog	Xenopus laevis	35-41
2611263-2	1989	The inactivation of TFIIIA by DEP as detected by an in vitro 5S RNA gene transcription assay was correlated with the extent of modification of histidine residues and Zn2+ release.	Zinc	166-170	general transcription factor 3A L homeolog	Xenopus laevis	20-26
2611263-6	1989	However, the reversibility could be inhibited by EDTA, suggesting that Zn2+ was required for the binding of TFIIIA to 5S RNA.	Zinc	71-75	general transcription factor 3A L homeolog	Xenopus laevis	108-114
2611263-7	1989	In the presence of PMPS- or DEP-modified TFIIIA or Zn2+-depleted TFIIIA, the fluorescence emission maximum of the hydrophobic probe, 8-anilinonaphthalenesulfonate, was blue-shifted by 30 nm, while only less than a 10-nm blue shift was observed in the presence of either the 7S particle or TFIIIA.	Zinc	51-55	general transcription factor 3A L homeolog	Xenopus laevis	41-47
2611263-7	1989	In the presence of PMPS- or DEP-modified TFIIIA or Zn2+-depleted TFIIIA, the fluorescence emission maximum of the hydrophobic probe, 8-anilinonaphthalenesulfonate, was blue-shifted by 30 nm, while only less than a 10-nm blue shift was observed in the presence of either the 7S particle or TFIIIA.	Zinc	51-55	general transcription factor 3A L homeolog	Xenopus laevis	65-71
2611263-7	1989	In the presence of PMPS- or DEP-modified TFIIIA or Zn2+-depleted TFIIIA, the fluorescence emission maximum of the hydrophobic probe, 8-anilinonaphthalenesulfonate, was blue-shifted by 30 nm, while only less than a 10-nm blue shift was observed in the presence of either the 7S particle or TFIIIA.	Zinc	51-55	general transcription factor 3A L homeolog	Xenopus laevis	65-71
2583073-5	1989	The induction of pulmonary Cu/Zn-thionein was accompanied by an acute phase response, characterized by elevated serum Cu and ceruloplasmin levels and depressed serum Zn.	Zinc	30-32	ceruloplasmin	Homo sapiens	125-138
2718914-3	1989	Zn concentrations in milk declined throughout lactation from 71.9 +/- 18.3 mumol/L (means +/- SD) at 7 d to 44.3 +/- 10.7 mumol/L at 1 mo and 7.64 +/- 4.59 mumol/L at 12 mo.	Zinc	0-2	solute carrier family 7 member 5	Homo sapiens	128-134
3167029-2	1988	Experiments have been performed with LAP species containing Mg(II), Mn(II), Ni(II), Cu(II), Zn(II), and no metal ion at the regulatory metal binding site.	Zinc	92-98	LAP	Homo sapiens	37-40
3167030-2	1988	Experiments have been carried out on LAP species containing Mg(II), Mn(II), Cu(II), Ni(II), Zn(II), and no metal ion at the regulatory metal binding site.	Zinc	92-98	LAP	Homo sapiens	37-40
3167030-5	1988	The pre-steady-state reactions carried out under nonturnover conditions at -35 degrees C reveal a new relaxation for LAP species with Ni(II), Cu(II), and Zn(II) in the regulatory site.	Zinc	154-160	LAP	Homo sapiens	117-120
3263342-6	1988	Ni and Zn significantly enhanced the synthesis/secretion of IL-2 by cultured splenocytes and the expression of the receptor for IL-2; however, Pb produced only slight enhancement.	Zinc	7-9	interleukin 2	Mus musculus	60-64
3263342-6	1988	Ni and Zn significantly enhanced the synthesis/secretion of IL-2 by cultured splenocytes and the expression of the receptor for IL-2; however, Pb produced only slight enhancement.	Zinc	7-9	interleukin 2	Mus musculus	128-132
3263342-7	1988	Likewise, anti-IL-2 receptor (7D4) antibodies were able to inhibit a significant portion of the Ni- and Zn-, but not Pb-, induced lymphoproliferation.	Zinc	104-106	interleukin 2	Mus musculus	15-19
3263342-10	1988	The Pb-induced response being the least dependent on IL-2 lends support to the hypothesis that Pb, Ni and Zn may activate T-cells and/or B-cells by different mechanisms.	Zinc	106-108	interleukin 2	Mus musculus	53-57
3676288-1	1987	alpha-Lactalbumin (alpha-LA) is a calcium binding protein that also binds Mn(II), lanthanide ions, A1(III), Zn(II), Co(II).	Zinc	108-114	lactalbumin alpha	Bos taurus	0-17
3676288-1	1987	alpha-Lactalbumin (alpha-LA) is a calcium binding protein that also binds Mn(II), lanthanide ions, A1(III), Zn(II), Co(II).	Zinc	108-114	lactalbumin alpha	Bos taurus	19-27
2440383-1	1987	When alpha 2-macroglobulin (alpha 2M) is reacted with proteinases including trypsin, plasmin, alpha-thrombin, or with CH3NH2, each resulting alpha 2M derivative is precipitated by Zn2+ in a similar manner.	Zinc	180-184	alpha-2-macroglobulin	Homo sapiens	5-26
2440383-1	1987	When alpha 2-macroglobulin (alpha 2M) is reacted with proteinases including trypsin, plasmin, alpha-thrombin, or with CH3NH2, each resulting alpha 2M derivative is precipitated by Zn2+ in a similar manner.	Zinc	180-184	alpha-2-macroglobulin	Homo sapiens	28-36
3492923-2	1987	We studied the role of granulocytes and lactoferrin (LF) in endotoxin and murine interleukin 1 (IL-1)-induced depression of serum Fe and Zn concentrations in both rabbits and rats.	Zinc	137-139	lactotransferrin	Mus musculus	53-55
20501113-8	1987	The carboxypeptidase B was characterized by a strong activation by -SH agents and Zn(2+), and thus could be differentiated from other opioid converting enzymes.	Zinc	82-84	carboxypeptidase B1	Rattus norvegicus	4-22
16665185-2	1987	The reversal of Cd(2+) and Zn(2+) inhibition, in contrast to Cu(2+), by exogenously added catalase (EC 1.11.1.6) suggested that the former cations were inhibitory to H(2)O(2) degradation.	Zinc	27-29	pfam00199	Synechococcus elongatus PCC 7942	90-98
3090432-2	1986	The kinetic characteristics and inhibition by Zn indicated that the residual activity was responsible for the intrinsic activity of acid alpha-glucosidase.	Zinc	46-48	lysosomal alpha-glucosidase	Coturnix japonica	132-154
3011986-1	1986	alpha-lactalbumin has at least three distinct cation binding regions: a Ca(II)-Gd(III) site, a Cu(II)-Zn(II) site and a VO2+ site as observed from electron paramagnetic resonance (EPR) studies of complexes with the bovine protein.	Zinc	102-104	lactalbumin alpha	Bos taurus	0-17
3011986-10	1986	On the other hand, addition of Zn(II) to Cu(II)-alpha-lactalbumin gave a set of EPR lines due to free or loosely bound Cu(II), confirming that the Cu(II) was displaced by zinc.	Zinc	31-37	lactalbumin alpha	Bos taurus	48-65
3005470-0	1985	Mode of inhibitory action of Zn2+, Hg2+ and UO2(2+) on 5"-nucleotidase of mouse hepatic microsomes.	Zinc	29-33	5' nucleotidase, ecto	Mus musculus	55-70
4003387-7	1985	As an extension of these findings, we examined the effect of Zn+2 on the inhibition of thrombin by antithrombin-III (AT-III).	Zinc	61-65	serpin family C member 1	Homo sapiens	99-115
4003387-8	1985	The presence of as little as 0.006 mM Zn+2 in an incubating mixture of thrombin and AT-III severely reduced the inhibitory activity of AT-III towards thrombin.	Zinc	38-42	serpin family C member 1	Homo sapiens	84-90
4003387-8	1985	The presence of as little as 0.006 mM Zn+2 in an incubating mixture of thrombin and AT-III severely reduced the inhibitory activity of AT-III towards thrombin.	Zinc	38-42	serpin family C member 1	Homo sapiens	135-141
4003387-10	1985	It is suggested that Zn+2 can form a complex with thrombin, which results in altered reactivity towards fibrinogen and decreased inhibition by AT-III.	Zinc	21-25	serpin family C member 1	Homo sapiens	143-149
11460756-3	2000	According to the present work, both Cd2+ and Pb2+ displace Zn2+ from transcription factor IIIA (TFIIIA).	Zinc	59-63	general transcription factor 3A L homeolog	Xenopus laevis	69-94
3888954-3	1985	The addition of 20 microM Cd2+ or Zn2+ (but not Mn2+) to the cell suspensions preloaded with 109Cd2+ caused the exchange of Cd2+.	Zinc	34-38	CD2 molecule	Homo sapiens	96-99
6470005-0	1984	Metal dissociation constants for glyoxalase I reconstituted with Zn2+, Co2+, Mn2+, and Mg2+.	Zinc	65-69	glyoxalase I	Homo sapiens	33-45
6469987-1	1984	The binding of Ca2+, Zn2+, Tb3+, and Mn2+ to metal-free bovine alpha-lactalbumin (apo-BLA) was studied by both analytical gel filtration using isotopic metal ions and by fluorescence titration.	Zinc	21-25	lactalbumin alpha	Bos taurus	63-80
6469988-11	1984	Millimolar concentrations of Zn2+ induce a time-dependent conformational change in both calcium-free and calcium-liganded alpha-lactalbumin to produce an "expanded A-like state" comparable to that seen with terbium at similar concentrations.	Zinc	29-33	lactalbumin alpha	Bos taurus	122-139
6712919-1	1984	X-ray edge and extended absorption fine structure spectra of Zn2+ at the active site of glyoxalase I have been measured.	Zinc	61-65	glyoxalase I	Homo sapiens	88-100
6712919-9	1984	105, 6596-6604], indicating at least two imidazole ligands to Zn2+ on glyoxalase I.	Zinc	62-66	glyoxalase I	Homo sapiens	70-82
6695405-1	1984	The in vivo effects of zinc (Zn) and manganese (Mn) on the activity of delta-aminolevulinic acid dehydratase (5-aminolevulinate hydrolyase, ALAD, EC 4.2.1.24) in blood with and without inhibition by lead and on the functions of the liver and kidney were studied in rabbits.	Zinc	29-31	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	71-108
6668728-1	1983	As the delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes is decreased by lead exposure, we considered that a net reduction of ALAD activity by lead in blood should be the difference between the activity fully activated with zinc (Zn2+) and dithiothreitol (DTT) and that without activation.	Zinc	250-254	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	7-44
6668728-1	1983	As the delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes is decreased by lead exposure, we considered that a net reduction of ALAD activity by lead in blood should be the difference between the activity fully activated with zinc (Zn2+) and dithiothreitol (DTT) and that without activation.	Zinc	250-254	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	46-50
6668728-1	1983	As the delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes is decreased by lead exposure, we considered that a net reduction of ALAD activity by lead in blood should be the difference between the activity fully activated with zinc (Zn2+) and dithiothreitol (DTT) and that without activation.	Zinc	250-254	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	146-150
6668728-2	1983	The optimal condition of activation of ALAD was found by addition of 0.25 mM of Zn2+ and 10 mM of DTT in the reaction mixture.	Zinc	80-84	delta-aminolevulinic acid dehydratase	Oryctolagus cuniculus	39-43
6304121-3	1983	Micromolar concentrations of Zn2+ ions inhibited the phosphorylation of the epidermal growth factor (EGF) receptor and of threonine residues in a 47,000-dalton polypeptide.	Zinc	29-33	epidermal growth factor receptor	Mus musculus	76-114
6298535-2	1982	The carboxyl coordinating ability of the Zn atom seems to be significantly higher in ACE than in "enkephalinase".	Zinc	41-43	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	85-88
6298535-3	1982	Moreover, IC50 values against "enkephalinase" were found in the same range whatever the length of the chain bearing the carboxyl group whereas a well-defined position of this group with respect to the Zn atom is required for strong ACE inhibition.	Zinc	201-203	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	232-235
7263672-13	1981	Studies with metal-depleted galactosyltransferase activated with Zn2+ or Co2+ and apo-alpha-lactalbumin or Ca2+-saturated alpha-lactalbumin show that the Ca2+, Zn2+, and apo-alpha-lactalbumin are all able to bind with galactosyltransferase to produce an active lactose synthase complex.	Zinc	65-69	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	28-49
7263672-13	1981	Studies with metal-depleted galactosyltransferase activated with Zn2+ or Co2+ and apo-alpha-lactalbumin or Ca2+-saturated alpha-lactalbumin show that the Ca2+, Zn2+, and apo-alpha-lactalbumin are all able to bind with galactosyltransferase to produce an active lactose synthase complex.	Zinc	160-164	lactalbumin alpha	Bos taurus	86-103
7263672-13	1981	Studies with metal-depleted galactosyltransferase activated with Zn2+ or Co2+ and apo-alpha-lactalbumin or Ca2+-saturated alpha-lactalbumin show that the Ca2+, Zn2+, and apo-alpha-lactalbumin are all able to bind with galactosyltransferase to produce an active lactose synthase complex.	Zinc	160-164	lactalbumin alpha	Bos taurus	122-139
7263672-13	1981	Studies with metal-depleted galactosyltransferase activated with Zn2+ or Co2+ and apo-alpha-lactalbumin or Ca2+-saturated alpha-lactalbumin show that the Ca2+, Zn2+, and apo-alpha-lactalbumin are all able to bind with galactosyltransferase to produce an active lactose synthase complex.	Zinc	160-164	lactalbumin alpha	Bos taurus	122-139
7263672-13	1981	Studies with metal-depleted galactosyltransferase activated with Zn2+ or Co2+ and apo-alpha-lactalbumin or Ca2+-saturated alpha-lactalbumin show that the Ca2+, Zn2+, and apo-alpha-lactalbumin are all able to bind with galactosyltransferase to produce an active lactose synthase complex.	Zinc	160-164	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	218-239
7354072-12	1980	Possible mechanistic roles for Zn2+ in porphobilinogen synthase are discussed.	Zinc	31-35	aminolevulinate dehydratase	Bos taurus	39-63
11460756-3	2000	According to the present work, both Cd2+ and Pb2+ displace Zn2+ from transcription factor IIIA (TFIIIA).	Zinc	59-63	general transcription factor 3A L homeolog	Xenopus laevis	96-102
11460756-4	2000	Neither product binds to the internal control region (ICR) of the 5 S rRNA gene, the normal binding site for Zn-TFIIIA.	Zinc	109-111	general transcription factor 3A L homeolog	Xenopus laevis	112-118
73385-8	1977	Our results also indicate that the high zinc content of alpha-2-macroglobulin (320--770 microgram/g protein) reported in the literature is an artifact and that native alpha-2-macroglobulin contains approximately 150--180 microgram Zn/g protein.	Zinc	231-233	alpha-2-macroglobulin	Homo sapiens	167-188
11460756-7	2000	Similarly, Cd2+ and Zn2+ can be exchanged in the reaction of Cd-TFIIIA with Zn-MT.	Zinc	20-24	general transcription factor 3A L homeolog	Xenopus laevis	64-70
10813835-7	2000	Surprisingly, desMetE49A alpha-LA and the native bovine protein had similar affinities for both Zn(2+) and Ca(2+).	Zinc	96-102	lactalbumin alpha	Bos taurus	25-33
10850967-6	2000	In contrast, Zn(2+) stimulated the activity of CD38 HL-60 ADPR-cyclase and other known types of ADPR-cyclases.	Zinc	13-19	CD38 molecule	Homo sapiens	47-51
1009077-6	1976	Liver Cu concentrations were reduced by up to 40% in the Zn-supplemented animals, with concomitant reductions, especially in the early stages of the experiment, in the extent of liver damage, as assessed by measurement of plasma aspartate aminotransferase (EC 2.6.1.1) and arginase (EC 3.5.3.1) activities.	Zinc	57-59	aspartate aminotransferase, mitochondrial	Ovis aries	229-255
10631119-0	2000	Zn(2+)-mediated structure formation and compaction of the "natively unfolded" human prothymosin alpha.	Zinc	0-6	prothymosin alpha pseudogene 9	Homo sapiens	84-101
18961421-1	1974	A potentiometric and spectrophotometric investigation on the formation of zinc(II) complexes with Semi-Xylenol Orange (SXO or H(4)L) is reported.	Zinc	74-82	H4 clustered histone 7	Homo sapiens	126-131
10608803-0	1999	DNA distortion mechanism for transcriptional activation by ZntR, a Zn(II)-responsive MerR homologue in Escherichia coli.	Zinc	67-73	activator/repressor of mer operon	Escherichia coli	85-89
33675825-4	2021	ThT, DLS, CD and TEM confirm that Zn:Cu2S QDs effectively inhibited insulin fibrosis in a dose-dependent manner with lag phase time extended (beyond 13-time by Zn:Cu2S QDs of 1 mg mL-1), final fibril formation and the conversion from alpha-helix to beta-sheet reduced.	Zinc	34-36	L1 cell adhesion molecule	Mus musculus	180-184
10608803-2	1999	The Escherichia coli ZntR protein, a homologue of MerR, has recently been shown to mediate Zn(II)-responsive regulation of zntA, a gene involved in Zn(II) detoxification.	Zinc	91-97	activator/repressor of mer operon	Escherichia coli	50-54
10816730-8	1999	Inhibitory concentrations of Co2+, Ni2+ and Zn2+ on expression of the CUP1p/lacZ fusion gene were at least one order of magnitude higher than that of Cd2+ and Mn2+.	Zinc	44-48	metallothionein CUP1	Saccharomyces cerevisiae S288C	70-75
10564189-2	1999	Our results show that especially Zn(2+) and Cd(2+) are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs.	Zinc	33-35	heme oxygenase 1	Homo sapiens	107-112
33983441-6	2021	Cu, Zn, Alb and Cp were found associated with several inflammatory as well as nutritional biomarkers.GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment.	Zinc	118-120	ceruloplasmin	Homo sapiens	16-18
33983441-6	2021	Cu, Zn, Alb and Cp were found associated with several inflammatory as well as nutritional biomarkers.GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment.	Zinc	118-120	ceruloplasmin	Homo sapiens	16-18
33939443-4	2021	Here, we report leptin delivers C-peptide and Zn2+ to RBCs in a saturable and specific manner.	Zinc	46-50	leptin	Homo sapiens	16-22
33939443-8	2021	The RBC-derived ATP increased in the presence of a leptin/C-peptide/Zn2+ addition, in a concentration-dependent manner.	Zinc	68-72	leptin	Homo sapiens	51-57
10564189-2	1999	Our results show that especially Zn(2+) and Cd(2+) are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs.	Zinc	33-35	heat shock protein family B (small) member 1	Homo sapiens	127-132
10388757-1	1999	The proton and Zn2+ effects on the human ether-a-go-go related gene (HERG) channels were studied after expression in Xenopus oocytes and stable transfection in the mammalian L929 cell line.	Zinc	15-19	potassium voltage-gated channel subfamily H member 2	Homo sapiens	69-73
33924361-1	2021	TRPM7 plays an important role in cellular Ca2+, Zn2+ and Mg2+ homeostasis.	Zinc	48-52	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	0-5
10388757-11	1999	We conclude that protons and Zn2+ directly interact with HERG channels and that the interaction results, preferentially, in the regulation of channel deactivation mechanism.	Zinc	29-33	potassium voltage-gated channel subfamily H member 2	Homo sapiens	57-61
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Zinc	36-38	arginyl aminopeptidase	Rattus norvegicus	0-16
33918078-1	2021	The G-protein coupled receptor GPR39 is abundantly expressed in various tissues and can be activated by changes in extracellular Zn2+ in physiological concentrations.	Zinc	129-133	G protein-coupled receptor 39	Homo sapiens	31-36
33750840-4	2021	The Zn2+-dependent oligomerization properties of human CRISP1 were investigated using a maltose-binding protein (MBP)-tagging approach in combination with low expression levels in XL-1 Blue bacteria.	Zinc	4-8	cysteine rich secretory protein 1	Homo sapiens	55-61
10212220-4	1999	A recombinant 41-amino acid long peptide representing the N-terminal domain of decorin has full Zn2+ binding activity and binds two Zn2+ ions with an average KD of 3 x 10(-7) M. Binding of Zn2+ to this peptide results in a change in secondary structure as shown by circular dichroism spectroscopy.	Zinc	96-100	decorin	Homo sapiens	79-86
33750840-6	2021	Zn2+ specifically induced oligomerization of both MBP-CRISP1 and MBP-CRISP1DeltaC in vitro.	Zinc	0-4	cysteine rich secretory protein 1	Homo sapiens	54-60
33750840-6	2021	Zn2+ specifically induced oligomerization of both MBP-CRISP1 and MBP-CRISP1DeltaC in vitro.	Zinc	0-4	cysteine rich secretory protein 1	Homo sapiens	69-75
33750840-8	2021	Furthermore, MBP-CRISP1 and MBP-CRISP1DeltaC oligomers dissociated into monomers upon Zn2+ removal by EDTA.	Zinc	86-90	cysteine rich secretory protein 1	Homo sapiens	17-23
33750840-8	2021	Furthermore, MBP-CRISP1 and MBP-CRISP1DeltaC oligomers dissociated into monomers upon Zn2+ removal by EDTA.	Zinc	86-90	cysteine rich secretory protein 1	Homo sapiens	28-44
33750840-10	2021	The Zn2+-induced oligomerization of human recombinant CRISP1 may shed novel insights into the formation of functional protein complexes involved in mammalian fertilization.	Zinc	4-8	cysteine rich secretory protein 1	Homo sapiens	54-60
10212220-4	1999	A recombinant 41-amino acid long peptide representing the N-terminal domain of decorin has full Zn2+ binding activity and binds two Zn2+ ions with an average KD of 3 x 10(-7) M. Binding of Zn2+ to this peptide results in a change in secondary structure as shown by circular dichroism spectroscopy.	Zinc	132-136	decorin	Homo sapiens	79-86
10212220-4	1999	A recombinant 41-amino acid long peptide representing the N-terminal domain of decorin has full Zn2+ binding activity and binds two Zn2+ ions with an average KD of 3 x 10(-7) M. Binding of Zn2+ to this peptide results in a change in secondary structure as shown by circular dichroism spectroscopy.	Zinc	132-136	decorin	Homo sapiens	79-86
33748704-3	2021	Here, we investigate the function of the appended Zn2+-binding domain (ZBD) in the bifunctional AARS, glutamyl-prolyl-tRNA synthetase (GluProRS).	Zinc	50-54	alanyl-tRNA synthetase	Mus musculus	96-100
33673282-7	2021	Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone.	Zinc	90-94	methionine sulfoxide reductase A	Mus musculus	40-44
10096894-1	1999	We have investigated actions of various divalent cations (Ba2+, Sr2+, Mn2+, Co2+, Ni2+, Zn2+) on human ether-a-go-go related gene (HERG) channels expressed in Xenopus laevis oocytes using the voltage clamp technique.	Zinc	88-92	potassium voltage-gated channel subfamily H member 2	Homo sapiens	131-135
10342283-8	1999	These results suggest, first, MT-I &amp; -II may be induced in relation to the progress of the age-related morphological changes in the brain, playing an important role in the protection of the brain tissue from the toxic insults responsible for the brain aging, and second, MT-III may play a role in maintenance of Zn-related essential functions of the brain.	Zinc	316-318	metallothionein-1	Canis lupus familiaris	30-34
33257159-7	2021	The antibacterial activity of the mHAp samples depended strongly on their Zn2+ content.	Zinc	74-78	scaffold attachment factor B	Mus musculus	34-38
33257159-8	2021	Thus, the use of a biotemplate and Zn2+ ions is an efficient approach for the formation of novel HAp-based biomaterials with promising antibacterial properties.	Zinc	35-39	scaffold attachment factor B	Mus musculus	97-100
10201397-3	1999	We now show that the latter effect can be fully rescued by Zn2+ or Cd2+ using a phosphorodithioate substrate, in which both the 3"-oxygen and the pro-Sp oxygen are simultaneously substituted with sulfur.	Zinc	59-63	protein S (beta) pseudogene	Homo sapiens	146-152
32013770-2	2021	Zinc metal carboxylates (AAZ1 - AAZ6) were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Zinc	0-23	butyrylcholinesterase	Homo sapiens	93-114
9778374-11	1998	The significance of Cu- and Zn-clusters for the structure of native GIF is discussed.	Zinc	28-30	cobalamin binding intrinsic factor	Homo sapiens	68-71
33313613-3	2021	Utilizing the interaction between 6His-tag and nitrilotriacetic acid (NTA) mediated by divalent metal ions (Ni2+, Cu2+, Zn2+ or Co2+), we designed and synthesized a series of Nap-G/Biotin/ANA-FFpYGK-NTA probes that, assisted by alkaline phosphatase (ALP), self-assemble into nanofibers.	Zinc	120-124	NSF attachment protein gamma	Homo sapiens	175-180
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	41-43	transcription elongation factor A1	Homo sapiens	101-106
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	41-43	transcription elongation factor A1	Homo sapiens	183-188
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	88-90	transcription elongation factor A1	Homo sapiens	101-106
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	88-90	transcription elongation factor A1	Homo sapiens	183-188
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	88-90	transcription elongation factor A1	Homo sapiens	101-106
9770426-8	1998	Molecular modeling of the putative LEF-5 Zn ribbon using the NMR data available for the Zn ribbon of TFIIS suggested that this domain could fold into a Zn ribbon structure similar to TFIIS.	Zinc	88-90	transcription elongation factor A1	Homo sapiens	183-188
9756632-6	1998	Inductively coupled plasma (ICP) spectrometry demonstrated that MBP-DnaJ contains Fe ions as well as Zn ions.	Zinc	101-103	DnaJ	Escherichia coli	68-72
9756632-9	1998	MBP-DnaJ containing Fe and Zn ions, and MBP-DnaJ containing 2 Zn ions stimulated the ATPase activity of DnaK, prevented the aggregation of denatured rhodanase and bound to DNA to similar extents.	Zinc	62-64	DnaJ	Escherichia coli	44-48
9710597-7	1998	Mutation of two of the potential Zn2+ coordinating cysteines to serines in the RING finger completely abolished the ability of SNURF to enhance basal transcription, whereas its ability to activate steroid receptor-dependent transcription was maintained, suggesting that there are separate domains in SNURF that mediate interactions with different regulatory factors.	Zinc	33-37	SNRPN upstream open reading frame	Homo sapiens	127-132
9710597-7	1998	Mutation of two of the potential Zn2+ coordinating cysteines to serines in the RING finger completely abolished the ability of SNURF to enhance basal transcription, whereas its ability to activate steroid receptor-dependent transcription was maintained, suggesting that there are separate domains in SNURF that mediate interactions with different regulatory factors.	Zinc	33-37	SNRPN upstream open reading frame	Homo sapiens	300-305
9685718-7	1998	In cell-extracted cytosols, Zn2+ ions inhibited the cleavage of the 32-kDa precursor by caspase-9 (Aapf-3) that was activated by addition of cytochrome c and dATP.	Zinc	28-32	caspase 9	Homo sapiens	88-97
9848163-2	1998	The inhibiting effect of heavy metals cations on the both processes satisfies the succession: Pb2+ &gt; Zn2+ &gt; Cd2+.	Zinc	104-108	CD2 molecule	Homo sapiens	114-117
9500996-0	1998	Restricted Zn2+ availability affects the antizyme-dependent ornithine decarboxylase degradation pathway in isolated primary cultured rat hepatocytes.	Zinc	11-15	ornithine decarboxylase 1	Rattus norvegicus	60-83
9500996-1	1998	We previously reported that lack of Zn2+ decreased ornithine decarboxylase (ODC) activity without any change in ODC messenger RNA levels and the half-life of ODC activity being about 2-fold more rapid in primary cultured adult rat hepatocytes, suggesting that lack of Zn2+ decreased ODC activity mainly by degrading the enzyme.	Zinc	36-40	ornithine decarboxylase 1	Rattus norvegicus	51-74
9500996-1	1998	We previously reported that lack of Zn2+ decreased ornithine decarboxylase (ODC) activity without any change in ODC messenger RNA levels and the half-life of ODC activity being about 2-fold more rapid in primary cultured adult rat hepatocytes, suggesting that lack of Zn2+ decreased ODC activity mainly by degrading the enzyme.	Zinc	36-40	ornithine decarboxylase 1	Rattus norvegicus	76-79
9500996-3	1998	These results indicate that a restricted Zn2+ availability affects the antizyme-dependent ODC degradation pathway and consequently decreases ODC activity in primary cultured rat hepatocytes.	Zinc	41-45	ornithine decarboxylase 1	Rattus norvegicus	90-93
9500996-3	1998	These results indicate that a restricted Zn2+ availability affects the antizyme-dependent ODC degradation pathway and consequently decreases ODC activity in primary cultured rat hepatocytes.	Zinc	41-45	ornithine decarboxylase 1	Rattus norvegicus	141-144
9341226-7	1997	The studies with Zn(II), Cd(II), and Co(II) ions indicated the presence of a Me3S9-cluster in GIF(1-32).	Zinc	17-23	cobalamin binding intrinsic factor	Homo sapiens	94-97
9341226-10	1997	The significance of Cu- and Zn-clusters for the structure of biologically active GIF(1-32) is discussed.	Zinc	28-30	cobalamin binding intrinsic factor	Homo sapiens	81-84
9254680-2	1997	A gerbil homolog of rat zinc transporter, ZnT-1, which transports intracellular Zn2+ out of cells, was isolated.	Zinc	80-84	solute carrier family 30 member 1	Rattus norvegicus	42-47
33320649-3	2021	This work examines neuropeptide Y (NPY) as a Zn2+ and Cu2+ chelator agent.	Zinc	45-49	neuropeptide Y	Homo sapiens	19-33
33320649-3	2021	This work examines neuropeptide Y (NPY) as a Zn2+ and Cu2+ chelator agent.	Zinc	45-49	neuropeptide Y	Homo sapiens	35-38
33320649-5	2021	Our simulations reveal that NPY has an efficient Zn2+ chelation activity but is less effective in chelating Cu2+.	Zinc	49-53	neuropeptide Y	Homo sapiens	28-31
33320649-7	2021	Beyond the exploration of the activity of NPY as a Zn2+ and Cu2+ chelator agent, this work provides an insight into the molecular mechanisms of the chelation of these metals at the molecular level.	Zinc	51-55	neuropeptide Y	Homo sapiens	42-45
33155397-9	2021	In the cerebral cortex, GFAP was similar between groups; Iba-1 was increased by CAF diet but reduced in the CAF+Zn group.	Zinc	112-114	allograft inflammatory factor 1	Rattus norvegicus	57-62
33241835-4	2020	The acidic microenvironment in cancer cells leads to the dissolution of the ZnO NPs to release Zn2+ ions and the intracellular miRNA-21 activates the Zn2+-dependent DNAzyme to cleave the substrate signal probes with the assistance of the Zn2+ cofactor to show green fluorescence for imaging miRNA-21.	Zinc	150-154	microRNA 21	Homo sapiens	127-135
33241835-4	2020	The acidic microenvironment in cancer cells leads to the dissolution of the ZnO NPs to release Zn2+ ions and the intracellular miRNA-21 activates the Zn2+-dependent DNAzyme to cleave the substrate signal probes with the assistance of the Zn2+ cofactor to show green fluorescence for imaging miRNA-21.	Zinc	150-154	microRNA 21	Homo sapiens	291-299
33241835-4	2020	The acidic microenvironment in cancer cells leads to the dissolution of the ZnO NPs to release Zn2+ ions and the intracellular miRNA-21 activates the Zn2+-dependent DNAzyme to cleave the substrate signal probes with the assistance of the Zn2+ cofactor to show green fluorescence for imaging miRNA-21.	Zinc	150-154	microRNA 21	Homo sapiens	127-135
33241835-4	2020	The acidic microenvironment in cancer cells leads to the dissolution of the ZnO NPs to release Zn2+ ions and the intracellular miRNA-21 activates the Zn2+-dependent DNAzyme to cleave the substrate signal probes with the assistance of the Zn2+ cofactor to show green fluorescence for imaging miRNA-21.	Zinc	150-154	microRNA 21	Homo sapiens	291-299
9254680-6	1997	Zn2+ was shown to accumulate in CA1 pyramidal neurons expressing ZnT-1 mRNA after the ischemia by using zinquin, a zinc-specific fluorescent dye.	Zinc	0-4	carbonic anhydrase 1	Rattus norvegicus	32-35
9254680-6	1997	Zn2+ was shown to accumulate in CA1 pyramidal neurons expressing ZnT-1 mRNA after the ischemia by using zinquin, a zinc-specific fluorescent dye.	Zinc	0-4	solute carrier family 30 member 1	Rattus norvegicus	65-70
9254680-7	1997	When primary hippocampal neurons were exposed to a high dose of Zn2+, ZnT-1 mRNA accumulated.	Zinc	64-68	solute carrier family 30 member 1	Rattus norvegicus	70-75
33079629-3	2020	In the present review, we use these data as a basis to examine the structure, function, and Zn2+-induced modulation of Cav2.3 VGCCs, which mediate native R-type currents and belong to the most enigmatic members of the family.	Zinc	92-96	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	119-125
9254680-8	1997	These results suggest that the induction of ZnT-1 mRNA observed in CA1 neurons was caused by an increase in the intracellular Zn2+ concentration.	Zinc	126-130	solute carrier family 30 member 1	Rattus norvegicus	44-49
33079629-6	2020	While still far from complete, the picture that emerges is one where Cav2.3 channel expression parallels the occurrence of loosely bound Zn2+ pools in different tissues and where these channels may serve to translate physiological Zn2+ signals into changes of electrical activity and/or intracellular Ca2+ levels.	Zinc	137-141	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	69-75
33079629-6	2020	While still far from complete, the picture that emerges is one where Cav2.3 channel expression parallels the occurrence of loosely bound Zn2+ pools in different tissues and where these channels may serve to translate physiological Zn2+ signals into changes of electrical activity and/or intracellular Ca2+ levels.	Zinc	231-235	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	69-75
9254680-8	1997	These results suggest that the induction of ZnT-1 mRNA observed in CA1 neurons was caused by an increase in the intracellular Zn2+ concentration.	Zinc	126-130	carbonic anhydrase 1	Rattus norvegicus	67-70
9256278-4	1997	Molecular modeling studies predict that Zn2+ binding to NGF will induce structural changes within domains of this neurotrophin that participate in the recognition of TrkA and p75NTR.	Zinc	40-44	nerve growth factor receptor	Homo sapiens	175-181
9233765-6	1997	Our data add N-myc to a growing list of mammalian genes with CT-boxes that bind proteins in a Zn2+-dependent manner.	Zinc	94-98	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
33248594-1	2020	This study investigated that circadian zinc (Zn) feeding regime affected laying performance, Zn and calcium (Ca) status, antioxidant capacity and gene expression of circadian clock, and Ca and Zn transporter in laying hens.	Zinc	45-47	clock circadian regulator	Gallus gallus	175-180
9199772-5	1997	We also found that free zinc (Zn2+), reported to bind to amyloid beta-protein in solution, can block the flow of Cs+ through the A beta P[1-40] channel.	Zinc	30-34	SRC kinase signaling inhibitor 1	Homo sapiens	136-142
33096823-7	2020	Extracellular Zn2+ affects intracellular signaling pathways through its interaction with the Zn2+ sensing receptor (ZnR), also named GPR39.	Zinc	14-18	G protein-coupled receptor 39	Homo sapiens	133-138
33096823-9	2020	Our studies showed that Zn2+ stimulates bovine sperm acrosomal exocytosis, as well as human sperm hyper-activated motility, were both mediated by GPR39.	Zinc	24-28	G protein-coupled receptor 39	Homo sapiens	146-151
9199772-6	1997	Because the Zn2+ chelator o-phenanthroline can reverse this blockade, we conclude that the underlying mechanism involves a direct interaction between the transition element Zn2+ and sites in the A beta P[1-40] channel pore.	Zinc	12-16	SRC kinase signaling inhibitor 1	Homo sapiens	202-208
33096823-10	2020	Zn2+ binds and activates GPR39, which activates the trans-membrane-adenylyl-cyclase (tmAC) to catalyze cAMP production.	Zinc	0-4	G protein-coupled receptor 39	Homo sapiens	25-30
9199772-6	1997	Because the Zn2+ chelator o-phenanthroline can reverse this blockade, we conclude that the underlying mechanism involves a direct interaction between the transition element Zn2+ and sites in the A beta P[1-40] channel pore.	Zinc	173-177	SRC kinase signaling inhibitor 1	Homo sapiens	202-208
9202307-4	1997	This domain includes a cysteine-rich, Zn2+-binding domain whose integrity is also required for Rab3a-GTP binding and the ability to inhibit secretion.	Zinc	38-42	RAB3A, member RAS oncogene family	Bos taurus	95-100
32302450-8	2020	Moreover, a glutamate transporter (EAAT) was the molecular entity for the action of Zn2+ on glutamate uptake by which Zn2+ decreases glutamate availability.	Zinc	84-88	solute carrier family 1 member 3	Rattus norvegicus	12-33
32302450-8	2020	Moreover, a glutamate transporter (EAAT) was the molecular entity for the action of Zn2+ on glutamate uptake by which Zn2+ decreases glutamate availability.	Zinc	118-122	solute carrier family 1 member 3	Rattus norvegicus	12-33
9153200-8	1997	The HRG.Zn complex effectively competes with antithrombin for heparin, which restricts the availability of heparin to bind antithrombin and allows thrombin-mediated fibrinogenesis to proceed unimpeded.	Zinc	8-10	serpin family C member 1	Homo sapiens	45-57
9153200-8	1997	The HRG.Zn complex effectively competes with antithrombin for heparin, which restricts the availability of heparin to bind antithrombin and allows thrombin-mediated fibrinogenesis to proceed unimpeded.	Zinc	8-10	serpin family C member 1	Homo sapiens	123-135
9211591-5	1997	Delta-aminolevulinic acid dehydratase (ALA-D) activities in the blood were found to increase significantly in Zn and BeZn groups when compared to the control level.	Zinc	110-112	aminolevulinate, delta-, dehydratase	Mus musculus	0-37
32991615-6	2020	We fed a semi-purified diet containing 30 mg Zn/kg to Znt7-/- mice with their heterozygous and wild type littermates and found a sex specific effect on colonic mucin density, goblet cell number, and microbiome composition.	Zinc	45-47	solute carrier family 30 (zinc transporter), member 7	Mus musculus	54-58
32987721-7	2020	In this review, we discuss Gd3+-based MR contrast agents that respond to a change in local Zn2+ concentration.	Zinc	91-95	GRDX	Homo sapiens	27-30
9211591-5	1997	Delta-aminolevulinic acid dehydratase (ALA-D) activities in the blood were found to increase significantly in Zn and BeZn groups when compared to the control level.	Zinc	110-112	aminolevulinate, delta-, dehydratase	Mus musculus	39-44
9211591-8	1997	The splenic ALA-D activities were significantly higher in the Zn and BeZn groups than in the control and Be groups.	Zinc	62-64	aminolevulinate, delta-, dehydratase	Mus musculus	12-17
9211591-10	1997	An increase in ALA-D activities in the blood and spleen was observed in the BeZn group, together with an increase in ALA-D activities caused by Zn administration.	Zinc	78-80	aminolevulinate, delta-, dehydratase	Mus musculus	15-20
9110410-9	1997	The data demonstrate that: 1) Zn2+ is a potent inducer of HSP70 expression; 2) the application of Zn2+ leads to slightly increased cytokine plasma levels; and 3) the manipulation of the heat shock response by Zn2+ significantly increases the survival rate after LD100 endotoxemia.	Zinc	30-34	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	58-63
32557022-6	2020	Our results demonstrate significant correlations between the metals tested and the proteins associated with renal damage; Cys-C, OPN, and RPB4 showed a significant correlation with Li, B, and Mo, as well as hippuric acid in the case of Cys-C and Zn in OPN and RPB-4; NGAL did not present significant correlations with any of the pollutants of the study.	Zinc	246-248	secreted phosphoprotein 1	Homo sapiens	129-132
32687683-2	2020	Herein, an inorganic nanocomposite material Ag2 S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector.	Zinc	50-53	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	44-47
32687683-3	2020	Compared with a single ZnS material, the Ag2 S@ZnS composite shows many uneven nano-protrusions on the surface of the microspheres.	Zinc	23-26	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	41-44
32687683-3	2020	Compared with a single ZnS material, the Ag2 S@ZnS composite shows many uneven nano-protrusions on the surface of the microspheres.	Zinc	47-50	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	41-44
9110410-9	1997	The data demonstrate that: 1) Zn2+ is a potent inducer of HSP70 expression; 2) the application of Zn2+ leads to slightly increased cytokine plasma levels; and 3) the manipulation of the heat shock response by Zn2+ significantly increases the survival rate after LD100 endotoxemia.	Zinc	98-102	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	58-63
9110410-9	1997	The data demonstrate that: 1) Zn2+ is a potent inducer of HSP70 expression; 2) the application of Zn2+ leads to slightly increased cytokine plasma levels; and 3) the manipulation of the heat shock response by Zn2+ significantly increases the survival rate after LD100 endotoxemia.	Zinc	98-102	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	58-63
32824906-2	2020	Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT promoters, in response to Zn and Cd.	Zinc	176-178	metal response element binding transcription factor 1	Mus musculus	36-95
9110410-10	1997	Enhanced survival rate in animals pretreated with Zn2+ may be explained by increased tissue levels of HSP70, a subsequent significantly decreased liberation of the proinflammatory cytokines after LPS challenge, and a significantly decreased rate of apoptosis.	Zinc	50-54	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	102-107
32824906-2	2020	Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT promoters, in response to Zn and Cd.	Zinc	176-178	metal response element binding transcription factor 1	Mus musculus	97-101
9063449-4	1997	Deletion of the complete active-site [des-(161-228)-MMP-1] within the catalytic domain, or mutation of a single His residue of the Zn2+ binding domain (His199), generates stable forms of MMP-1 proteins which are unable to digest collagen type I or beta-casein.	Zinc	131-135	matrix metallopeptidase 1	Homo sapiens	187-192
32799855-11	2020	CONCLUSION: PKPM, PGCL, PURL, PULV and PMNP exhibit neuroprotective effects against neuronal damage induced by Zn and this may be attributed to inhibition of apoptosis, oxidative damage and acetylcholinesterase activity.	Zinc	111-113	phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)	Mus musculus	24-28
31828721-6	2020	Zn also increases phosphatidylinositol 3-kinase (PI3K)/Akt and glycogen synthase kinase-3beta (GSK-3beta) phosphorylation and preserves protein kinase C isoforms.	Zinc	0-2	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	18-47
9063449-9	1997	In summary, we have shown that the integrity of the catalytic domain of MMP-1 and its ability to bind Zn2+ is absolutely required for complex formation with TIMP-1, which further underlines the importance of this region for proper regulation of enzymatic activity of MMP-1.	Zinc	102-106	matrix metallopeptidase 1	Homo sapiens	72-77
9063449-9	1997	In summary, we have shown that the integrity of the catalytic domain of MMP-1 and its ability to bind Zn2+ is absolutely required for complex formation with TIMP-1, which further underlines the importance of this region for proper regulation of enzymatic activity of MMP-1.	Zinc	102-106	matrix metallopeptidase 1	Homo sapiens	267-272
31968444-1	2020	Thermal properties and microstructure of Al-4 wt.% Zn-2 wt.% Cu-x (x = 2 wt%.	Zinc	51-53	G antigen 7	Homo sapiens	41-45
31968444-6	2020	The thermal conductivity with temperature and composition of as-extruded Al-4 wt.% Zn-2 wt.% Cu-x alloys decreases with adding 2 wt.% Mg, 2 wt.% Sn contents from 190.925 and 196.451 W/mK but thermal properties of addition of 0.7 wt.% Mg-0.7 wt.% Sn-0.7 wt.% Ca element slightly reduced from 222.32 to 180.775 W/mK.	Zinc	83-85	G antigen 7	Homo sapiens	73-77
8979149-0	1996	Zinc (Zn2+) binds to and stimulates the activity of group I but not group II phospholipase A2.	Zinc	6-10	phospholipase A2 group IB	Rattus norvegicus	77-93
32463408-5	2020	Zn and Hg induced G0/G1 cell arrest and apoptotic cell death detected via typical DNA condensation/fragmentation, annexin V staining and caspase 3/7 activity in A549 and MCF-7 cells.	Zinc	0-2	annexin A5	Homo sapiens	114-123
8979149-2	1996	In the present study, the influence of zinc (Zn2+) on the activity of group I and group II phospholipase A2 was examined in vitro.	Zinc	45-49	phospholipase A2 group IB	Rattus norvegicus	91-107
8979149-3	1996	It appeared that Zn2+ (0.04-1 x 10(-3)M) increased group I phospholipase A2 activity from porcine pancreas and rat lung whereas the activity of group II phospholipase A2 from Crotalus atrox and Vipera russelli was unaffected.	Zinc	17-21	phospholipase A2 group IB	Rattus norvegicus	59-75
8979149-3	1996	It appeared that Zn2+ (0.04-1 x 10(-3)M) increased group I phospholipase A2 activity from porcine pancreas and rat lung whereas the activity of group II phospholipase A2 from Crotalus atrox and Vipera russelli was unaffected.	Zinc	17-21	phospholipase A2 group IB	Rattus norvegicus	153-169
8979149-5	1996	The selective stimulation of group I phospholipase A2 by Zn2+ corresponded to a binding of these phospholipases A2 to a zinc-affinity column, while group II phospholipase A2 was not bound.	Zinc	57-61	phospholipase A2 group IB	Rattus norvegicus	37-53
8979149-7	1996	These results indicate that Zn2+ binds to and increases the activity of group I, but not group II phospholipase A2.	Zinc	28-32	phospholipase A2 group IB	Rattus norvegicus	98-114
8979149-8	1996	This difference in Zn(2+)-binding may be used to discriminate between group I and group II phospholipase A2 and to separate the enzymes from each other in complex biological materials.	Zinc	19-25	phospholipase A2 group IB	Rattus norvegicus	91-107
8894652-7	1996	Interestingly, divalent cations, such as Zn+2 (1 mM) and Ca+2 (10 mM) also inhibited the IGFBP-5 proteolysis.	Zinc	41-45	insulin-like growth factor binding protein 5	Rattus norvegicus	89-96
31851525-5	2020	Supplementation of the diet with Zn did not change the dry matter intake (DMI) of calves during d 7 to 30 but increased the ADG in this period (p &lt; 0.05).	Zinc	33-35	ADG	Bos taurus	124-127
31851525-6	2020	During age periods of 31 to 70 and 71 to 100 d, DMI and ADG of the Zn supplemented calves were higher (p &lt; 0.05) than the control animals.	Zinc	67-69	ADG	Bos taurus	56-59
31427180-5	2020	Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls.	Zinc	7-9	immunoglobulin heavy diversity 1-7	Homo sapiens	36-39
8880741-2	1996	Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors.	Zinc	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	60-63
31427180-5	2020	Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls.	Zinc	21-23	immunoglobulin heavy diversity 1-7	Homo sapiens	36-39
8880741-2	1996	Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors.	Zinc	0-4	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	64-68
8880741-2	1996	Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors.	Zinc	0-4	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	73-76
8880741-3	1996	At NR1/NR2B receptors the Zn2+ concentration-inhibition curve was monophasic, with an apparent affinity for Zn2/ of 1.6 microM, and inhibition by Zn2+ was not voltage-dependent.	Zinc	26-30	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	3-6
8880741-3	1996	At NR1/NR2B receptors the Zn2+ concentration-inhibition curve was monophasic, with an apparent affinity for Zn2/ of 1.6 microM, and inhibition by Zn2+ was not voltage-dependent.	Zinc	26-30	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	7-11
8880741-4	1996	In contrast, the Zn2+ concentration-inhibition curve at NR1/NR2A receptors was biphasic, with high (Ki = 0.08 microM) and low (Ki = 30 microM) affinity components.	Zinc	17-21	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	56-59
31748061-3	2020	Thin film of Zn(O,S) is a favorable contender to substitute CdS thin film as buffer layer for CuInGaSe2 (CIGS), CuInGa(S,Se)2 (CIGSSe), Cu2ZnSn(S,Se)4 (CZTSSe) Cu2ZnSnSe4 (CZTSe), Cu2ZnSnS4 (CZTS) thin film absorber material based photovoltaic due to it made from earth abundant, low cost, non-toxic materials and its ability to improve the efficiency of chalcogenide and kesterite based photovoltaic due to wider band-gap which results in reduction of absorption loss compared to CdS.	Zinc	13-15	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
31748061-3	2020	Thin film of Zn(O,S) is a favorable contender to substitute CdS thin film as buffer layer for CuInGaSe2 (CIGS), CuInGa(S,Se)2 (CIGSSe), Cu2ZnSn(S,Se)4 (CZTSSe) Cu2ZnSnSe4 (CZTSe), Cu2ZnSnS4 (CZTS) thin film absorber material based photovoltaic due to it made from earth abundant, low cost, non-toxic materials and its ability to improve the efficiency of chalcogenide and kesterite based photovoltaic due to wider band-gap which results in reduction of absorption loss compared to CdS.	Zinc	13-15	CDP-diacylglycerol synthase 1	Homo sapiens	481-484
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	68-71
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	85-88
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	89-93
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	85-88
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	85-88
32426531-7	2020	Molecular docked models suggested the formation of coordinate bond between sulphur of allylmercaptan and Zn2+ cofactor of HDAC8.	Zinc	105-109	histone deacetylase 8	Homo sapiens	122-127
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	6-10	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	171-175
8880741-6	1996	Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors.	Zinc	131-135	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	171-175
8880741-7	1996	The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+.	Zinc	30-34	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	49-52
8880741-7	1996	The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+.	Zinc	143-147	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	49-52
32440120-0	2020	The NLRP3-Mediated Neuroinflammatory Responses to CdTe Quantum Dots and the Protection of ZnS Shell.	Zinc	90-93	NLR family, pyrin domain containing 3	Mus musculus	4-9
8694771-15	1996	The (beta 1-3)GalT was unaffected by Ca2+ ions, but were irreversibly inactivated by micromolar levels of transition metal ions (Cu2+ &gt; Zn2+ &gt; Ni2 &gt; Co2+).	Zinc	139-143	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	5-13
8864569-5	1996	Besides Na+ and K+, several divalent cations were effective in the sequence: Ca2+ &gt; Mn2+ &gt; Ba2+ &gt; Cd2+ &gt; Mg2+ &gt; Co2+ &gt; Zn2+ &gt; Ni2+.	Zinc	137-141	CD2 molecule	Homo sapiens	107-110
31309446-11	2020	All the data indicated that Zn deficiency significantly enhanced the harm to the testis induced by oxidative stress and damage, while CCl4 stimulation exacerbated the oxidative damage in testicular cells, leading to apoptosis through the activation of p53, MAPK, and NF-kappaB.	Zinc	28-30	transformation related protein 53, pseudogene	Mus musculus	252-255
8706705-3	1996	Zinc ions stimulated the ADP-ribosyl cyclase activity of MBP-CD38, but inversely inhibited its NAD+ glycohydrolase activity which was approximately 100-fold dominant to the cyclase activity in the absence of Zn2+.	Zinc	208-212	CD38 molecule	Homo sapiens	61-65
8706705-4	1996	Such dual effects of Zn2+ were also observed in the native membrane-bound CD38 of HL-60 cells which had been caused to differentiate by retinoic acid.	Zinc	21-25	CD38 molecule	Homo sapiens	74-78
31918077-2	2020	In this study, we analysed the stoichiometry of ShMT yielded in vivo and exchange reactions of the Zn-ShMT with Cd2+, Pb2+ and Cu2+in vitro via electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS), circular dichroism (CD) spectroscopy, inductively coupled plasma mass spectrometry (ICP-MS), and isothermal titration calorimetry (ITC).	Zinc	99-101	serine hydroxymethyltransferase 1	Homo sapiens	102-106
31918077-2	2020	In this study, we analysed the stoichiometry of ShMT yielded in vivo and exchange reactions of the Zn-ShMT with Cd2+, Pb2+ and Cu2+in vitro via electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS), circular dichroism (CD) spectroscopy, inductively coupled plasma mass spectrometry (ICP-MS), and isothermal titration calorimetry (ITC).	Zinc	99-101	CD2 molecule	Homo sapiens	112-115
8706705-7	1996	The fluorescence increase was further enhanced by the addition of Zn2+ with a shift in the maximum emission wavelength from 484 nm to 470 nm, suggesting that Zn2+ caused conformational changes of MBP-CD38.	Zinc	66-70	CD38 molecule	Homo sapiens	200-204
8706705-7	1996	The fluorescence increase was further enhanced by the addition of Zn2+ with a shift in the maximum emission wavelength from 484 nm to 470 nm, suggesting that Zn2+ caused conformational changes of MBP-CD38.	Zinc	158-162	CD38 molecule	Homo sapiens	200-204
8706705-8	1996	These results indicate that Zn2+ directly interacts with CD38 to stimulate its ADP-ribosyl cyclase with inhibition of its NAD+ glycohydrolase, probably due to prevention of the access of water molecule to an intermediate of the enzymesubstrate complex.	Zinc	28-32	CD38 molecule	Homo sapiens	57-61
8632476-5	1996	Interestingly, H3 codons 202 to 974, which encloses B1 and B2 (containing the Zn-binding CX2CX2CX4CX2CX2C motif from codon 533 to 550) binds preferentially to 0.8 kb duplexes, as compared with 0.4 to 0.6 kb duplexes.	Zinc	78-80	membrane spanning 4-domains A1	Homo sapiens	52-61
32523419-0	2020	Direct linearization approach to discrete integrable systems associated with ZN graded Lax pairs.	Zinc	77-79	lymphocyte transmembrane adaptor 1	Homo sapiens	87-90
15299718-5	1996	Pb(II) can be used to differentiate the two different Zn(II)-binding sites; diffraction-quality crystals of the Pb(II) complex of PBGS have been obtained.	Zinc	54-60	aminolevulinate dehydratase	Bos taurus	130-134
31999287-4	2020	The presence of ATP will trigger the decomposition of PDI@ZIF-8 due to much stronger coordination between ATP and Zn2+ than that of 2-methylimidazole and Zn2+.	Zinc	114-118	peptidyl arginine deiminase 1	Homo sapiens	54-63
31999287-4	2020	The presence of ATP will trigger the decomposition of PDI@ZIF-8 due to much stronger coordination between ATP and Zn2+ than that of 2-methylimidazole and Zn2+.	Zinc	154-158	peptidyl arginine deiminase 1	Homo sapiens	54-63
8634288-4	1996	The results are consistent with the N-terminal halves of AMT1 and ACE1 consisting of two independent submodules, one binding a single Zn(II) ion and the second binding the tetracopper cluster.	Zinc	134-140	Cup2p	Saccharomyces cerevisiae S288C	66-70
8634288-12	1996	The sequence homology between AMT1, ACE1, and MAC1 in the N-terminal 42 residues suggests that ACE1 and MAC1 will, likewise, contain N-terminal Zn modules.	Zinc	144-146	Cup2p	Saccharomyces cerevisiae S288C	36-40
8573078-0	1996	Antigenicity and conformational analysis of the Zn(2+)-binding sites of two Zn(2+)-metalloproteases: Leishmania gp63 and mammalian endopeptidase-24.11.	Zinc	48-54	leishmanolysin like peptidase	Homo sapiens	112-116
31927511-1	2020	A quinoline-based hydrazone, namely, bis((quinolin-8-yl)methylene)carbonohydrazide (1), has been designed and synthesized, which could be used as a dual probe for selective recognition of Co2+ and Zn2+ by monitoring changes in absorption and fluorescence spectral pattern, respectively.	Zinc	197-201	complement C2	Homo sapiens	188-191
31927511-3	2020	The complex formation between 1 and Co2+/Zn2+ is responsible for the detection process, as confirmed through several spectral methods and DFT calculations.	Zinc	41-44	complement C2	Homo sapiens	36-39
7987844-6	1994	DDP-selected cells were 15-fold resistant to DDP and 4.4-fold cross-resistant to antimony potassium tartrate, whereas of the cations tested (Cd2+, Zn2+, Ni2+ and Co2+) cross-resistance was observed only for Cd2+ (2.4-fold).	Zinc	147-151	translocase of inner mitochondrial membrane 8A	Homo sapiens	0-3
31774616-1	2020	The first selective oxidation of methane to methanol is reported herein for zinc-exchanged MOR (Zn/MOR).	Zinc	96-98	opioid receptor mu 1	Homo sapiens	91-94
31774616-1	2020	The first selective oxidation of methane to methanol is reported herein for zinc-exchanged MOR (Zn/MOR).	Zinc	96-98	opioid receptor mu 1	Homo sapiens	99-102
31774616-5	2020	For Zn/MOR, two signals were observed in the 13 C MAS NMR spectrum, resulting from two distinct [Zn-CH 3 ] + species present in the 12 MR and 8 MR side pockets, as supported by additional NMR experiments.	Zinc	4-6	opioid receptor mu 1	Homo sapiens	7-10
31774616-5	2020	For Zn/MOR, two signals were observed in the 13 C MAS NMR spectrum, resulting from two distinct [Zn-CH 3 ] + species present in the 12 MR and 8 MR side pockets, as supported by additional NMR experiments.	Zinc	97-102	opioid receptor mu 1	Homo sapiens	7-10
7811688-3	1994	This region corresponds to helix A (13-20) in the crystal structure of the 2 Zn insulin hexamer.	Zinc	77-79	insulin	Bos taurus	80-87
32101795-2	2020	The proposed assay has shown an excellent selective fluorescence response toward Cd2+ ions over other ions like Al3+, Pb2+, Zn2+, Co2+, K+, Na+ and Sr2+.	Zinc	124-128	CD2 molecule	Homo sapiens	81-84
7890805-2	1994	Using NIH3T3 cells conditionally expressing v-sis from a metallothionein promoter, we show that the addition of Zn2+ stimulates the production of PDGF-B (v-sis) and elicits the expression of Egr-1 in a dose-dependent and time-regulated manner.	Zinc	112-116	platelet derived growth factor, B polypeptide	Mus musculus	146-152
32134645-4	2020	Zn species 4 is present as three isomers in solution including square-pyramidal [Ru(PPh3)2(C6H4PPh2)(ZnMe)] (5), that is formed via C-H reductive elimination and features unsaturated Ru and Zn centers and an axial Z-type [ZnMe]+ ligand.	Zinc	0-2	protein phosphatase 4 catalytic subunit	Homo sapiens	84-88
7890805-2	1994	Using NIH3T3 cells conditionally expressing v-sis from a metallothionein promoter, we show that the addition of Zn2+ stimulates the production of PDGF-B (v-sis) and elicits the expression of Egr-1 in a dose-dependent and time-regulated manner.	Zinc	112-116	early growth response 1	Mus musculus	191-196
32134645-4	2020	Zn species 4 is present as three isomers in solution including square-pyramidal [Ru(PPh3)2(C6H4PPh2)(ZnMe)] (5), that is formed via C-H reductive elimination and features unsaturated Ru and Zn centers and an axial Z-type [ZnMe]+ ligand.	Zinc	101-103	protein phosphatase 4 catalytic subunit	Homo sapiens	84-88
32134645-6	2020	4 reacts with H2 at -40  C to form [Ru(PPh3)3(H)3(ZnMe)], 8-Zn, and contrasts the analogous reactions of 1, 2, and 3 that all require heating to 60  C. This marked difference in reactivity reflects the ability of Zn to promote a rate-limiting C-H reductive elimination step, and calculations attribute this to a significant stabilization of 5 via Ru   Zn donation.	Zinc	50-52	protein phosphatase 4 catalytic subunit	Homo sapiens	39-43
7890805-3	1994	The signal is likely independent of protein kinase C, but depends on tyrosine kinase and other kinase activities and is mediated by c-Ha-Ras since the presence of dominant-negative mutants of Ras and Raf abrogates the induction of Egr-1 expression by Zn2+.	Zinc	251-255	early growth response 1	Mus musculus	231-236
7890805-5	1994	Transient assays also demonstrated that Zn2+ or activated Ras expression stimulate the activity of a 950 bp Egr-1 promoter-reporter gene construct and this is abrogated in the presence of mutant Ras and Raf.	Zinc	40-44	early growth response 1	Mus musculus	108-113
7961776-5	1994	Under these same conditions in solvent containing 5 mM Zn2+, biglycan exists predominantly as a hexamer, with s0(20,w) = 9.4 S and Mz approximately 600,000.	Zinc	55-59	biglycan	Bos taurus	61-69
32221723-1	2020	The present study shows that a dual-signal nanoprobe consisting of DNAzyme-functionalized porous carbon nanospheres (PCNs) responds to microRNA-21 and zinc ion (Zn2+).	Zinc	161-165	microRNA 21	Homo sapiens	135-146
32221723-3	2020	The recognition between microRNA-21 and its complementary strand in the PCNs induces the separation of Zn2+-specific DNAzyme from PCNs, thus resulting in the increase of green fluorescence, and the exogenous Zn2+ triggers the rupture of cleavage strand of DNAzyme and recovery of red fluorescence.	Zinc	103-107	microRNA 21	Homo sapiens	24-35
32221723-3	2020	The recognition between microRNA-21 and its complementary strand in the PCNs induces the separation of Zn2+-specific DNAzyme from PCNs, thus resulting in the increase of green fluorescence, and the exogenous Zn2+ triggers the rupture of cleavage strand of DNAzyme and recovery of red fluorescence.	Zinc	208-212	microRNA 21	Homo sapiens	24-35
7835822-7	1994	In the Zn-deficient rats the concentration of GH in the serum was significantly increased by 78%, while IGF-1 and insulin were significantly reduced by 28% and 25% respectively.	Zinc	7-9	insulin-like growth factor 1	Rattus norvegicus	104-109
7835822-8	1994	It is thought that the growth depression observed in the Zn-deficient rats in this study despite their identical feed intake is probably due to a reduced concentration of IGF-I and insulin and that the biological activity or the binding of GH to receptors is impaired in specific alimentary Zn deficiency.	Zinc	57-59	insulin-like growth factor 1	Rattus norvegicus	171-176
32149230-1	2020	S100A3 protein, a member of the EF-hand-type Ca2+-binding S100 protein family, undergoes a Ca2+-/Zn2+-induced structural change to a tetrameric state upon specific citrullination of R51 in human hair cuticular cells.	Zinc	97-101	S100 calcium binding protein A3	Homo sapiens	0-6
7516153-4	1994	Whereas alpha 2M in complex with bLPL still bound to Zn(2+)-Sepharose, bLPL lost the ability to bind to heparin-Sepharose.	Zinc	53-59	alpha-2-macroglobulin	Homo sapiens	8-16
32149230-7	2020	By contrast, addition of Ca2+/Zn2+ to WT led to nonspecific aggregation in SEC analysis and dynamic light scattering, suggesting that citrullination of S100A3 is essential for stabilization of the Ca2+-/Zn2+-bound state.	Zinc	30-34	S100 calcium binding protein A3	Homo sapiens	152-158
32149230-7	2020	By contrast, addition of Ca2+/Zn2+ to WT led to nonspecific aggregation in SEC analysis and dynamic light scattering, suggesting that citrullination of S100A3 is essential for stabilization of the Ca2+-/Zn2+-bound state.	Zinc	203-207	S100 calcium binding protein A3	Homo sapiens	152-158
32149230-8	2020	These findings will lead to the further development of structural analyses for the Ca2+-/Zn2+-bound S100A3.	Zinc	89-93	S100 calcium binding protein A3	Homo sapiens	100-106
31685320-4	2020	This can be realised through the adsorption of Cd2+ by ZnS nanoparticles, which have exhibited a Cd2+ uptake capacity of approximate 400 mg g-1.	Zinc	55-58	CD2 molecule	Homo sapiens	47-50
31685320-4	2020	This can be realised through the adsorption of Cd2+ by ZnS nanoparticles, which have exhibited a Cd2+ uptake capacity of approximate 400 mg g-1.	Zinc	55-58	CD2 molecule	Homo sapiens	97-100
31685320-9	2020	This work reveals a new mechanism for Cd2+ removal with ZnS and establishes a valuable starting point for further studies into the formation of solid solutions for hazardous heavy metal removal applications.	Zinc	56-59	CD2 molecule	Homo sapiens	38-41
31960837-1	2020	Herein, an environmentally friendly CoP/Zn2In2S5 catalyst is reported as a visible-light photocatalyst for the selective activation of the alpha-C-H bond of methanol to generate ethylene glycol with a selectivity of as high as 90%.	Zinc	40-42	caspase recruitment domain family member 16	Homo sapiens	36-39
31918281-12	2020	ZnO NPs could also significantly elevate the expression of Cyt-C, Apaf-1, Caspase-9 and Caspase-3 at mRNA and protein levels, leading to cell death.	Zinc	0-3	caspase 9	Homo sapiens	74-83
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	caspase 9	Homo sapiens	41-50
31918281-15	2020	ZnO NPs can also increase Cyt-C, Apaf-1, Caspase-9 and Caspase-3 expression at mRNA and protein levels in human MM cells, and initiate MM cell apoptosis, indicating that Cyt-C, Apaf-1, Caspase-9 and Caspase-3 play crucial roles in ZnO NPs-induced, mitochondria-mediated apoptosis in human MM cells.	Zinc	0-3	caspase 9	Homo sapiens	185-194
31852371-4	2020	The mRNA levels of ZnTs (ZnT5-7 &amp; ZnT9), ZIPs (ZIP6-10, ZIP13-14), and MT were significantly (p &lt; 0.05) higher in Saos-2 compared to THP-1 and RD.	Zinc	19-23	solute carrier family 30 member 5	Homo sapiens	25-29
31762283-1	2019	Bimetallic CuZn catalysts have been recently proposed as alternative in order to achieve selectivity control during the electrochemical reduction of CO2 (CO2RR).	Zinc	11-15	complement C2	Homo sapiens	154-159
31762283-11	2019	The evolution of the Cu-Zn interaction with time during CO2RR was found to be responsible for the change in the selectivity from CH4 over Cu-ZnO NPs to CO over CuZn alloy NPs.	Zinc	24-26	complement C2	Homo sapiens	56-61
31762283-11	2019	The evolution of the Cu-Zn interaction with time during CO2RR was found to be responsible for the change in the selectivity from CH4 over Cu-ZnO NPs to CO over CuZn alloy NPs.	Zinc	141-144	complement C2	Homo sapiens	56-61
31762283-11	2019	The evolution of the Cu-Zn interaction with time during CO2RR was found to be responsible for the change in the selectivity from CH4 over Cu-ZnO NPs to CO over CuZn alloy NPs.	Zinc	160-164	complement C2	Homo sapiens	56-61
31514091-9	2019	Hence, the simultaneous determination of Cp, hTf, alpha2M and the Hp-Hb complex in plasma in <25min has the potential to provide new insight into disease processes associated with the bioinorganic chemistry of Cu, Fe and Zn.	Zinc	221-223	ceruloplasmin	Homo sapiens	41-43
31526921-6	2019	The APCS-MLR and geo statistical analysis showed that sources of pollution: PC1 was Ni, Cr, Cu, Zn because of soil parent material.	Zinc	96-98	amyloid P component, serum	Homo sapiens	4-8
31526921-6	2019	The APCS-MLR and geo statistical analysis showed that sources of pollution: PC1 was Ni, Cr, Cu, Zn because of soil parent material.	Zinc	96-98	proprotein convertase subtilisin/kexin type 1	Homo sapiens	76-79
31588929-0	2019	Screening a specific Zn(ii)-binding peptide for improving the cognitive decline of Alzheimer"s disease in APP/PS1 transgenic mice by inhibiting Zn2+-mediated amyloid protein aggregation and neurotoxicity.	Zinc	144-148	presenilin 1	Mus musculus	110-113
31588929-1	2019	Zn2+ has been implicated in the progression of Alzheimer"s disease (AD), as amyloid-beta protein (Abeta) aggregation and neurotoxicity are mediated by zinc ions.	Zinc	0-4	amyloid beta (A4) precursor protein	Mus musculus	98-103
31200268-1	2019	A new naphthalenediol-based bis(salamo)-type fluorescent probe H4L for Zn2+ and CN- was reported.	Zinc	71-75	H4 clustered histone 7	Homo sapiens	63-66
31200268-2	2019	Probe H4L showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and obtained the L-Zn2+complex can only detect CN- in various anions.	Zinc	68-72	H4 clustered histone 7	Homo sapiens	6-9
31692471-0	2019	Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design.	Zinc	52-60	sonic hedgehog signaling molecule	Homo sapiens	13-35
31394422-2	2019	A three-dimensional network structure (...Au-SNH2 Mn+ H2NS-Au...) was formed after the Mn+ (Pb2+, Cd2+, Zn2+ and Ag+) coordinated the gold nanoparticles through the amino group in the thiol ligand, which promoted aurophilicity (...Au...Au...)	Zinc	104-108	CD2 molecule	Homo sapiens	98-101
8161453-2	1994	NR1 subunits with an N-terminal insert (termed N1) form receptors in Xenopus oocytes with greatly reduced potentiation by spermine and Zn2+.	Zinc	135-139	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	0-3
8161453-8	1994	The positively charged N1 may increase NMDA currents by causing a conformational change similar to that produced by spermine and Zn2+ in NR1 receptors lacking N1.	Zinc	129-133	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	137-140
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	213-215	beta-1,4-galactosyltransferase 1	Homo sapiens	90-106
8369307-4	1993	Furthermore, Zn2+ was shown to be a noncompetitive inhibitor of Fe2+ oxidation in rHF but a mixed inhibitor in HLF.	Zinc	13-17	HLF transcription factor, PAR bZIP family member	Homo sapiens	111-114
8369307-5	1993	These different forms of Zn2+ inhibition in the two proteins and the higher activity of HLF than expected, based on its H-chain composition as well as differences in their enzyme kinetic parameters, suggest that H- and L-chains cooperate in modulating the ferroxidase activity of the apoferritin even though the L-subunit lacks a ferroxidase site itself.	Zinc	25-29	HLF transcription factor, PAR bZIP family member	Homo sapiens	88-91
8369307-5	1993	These different forms of Zn2+ inhibition in the two proteins and the higher activity of HLF than expected, based on its H-chain composition as well as differences in their enzyme kinetic parameters, suggest that H- and L-chains cooperate in modulating the ferroxidase activity of the apoferritin even though the L-subunit lacks a ferroxidase site itself.	Zinc	25-29	ferritin heavy chain 1	Homo sapiens	284-295
8450837-3	1993	Zn2+ shifted the activation curves for all three K+ currents in the depolarizing direction and also shifted the steady state inactivation curve for hKv1.4 in the depolarizing direction.	Zinc	0-4	potassium voltage-gated channel subfamily A member 4	Homo sapiens	148-154
8450837-7	1993	The resulting modulation of gating of hKv1.4 by Zn2+ may well be of physiological significance, in view of the localization of this channel in mossy fiber nerve terminals in the hippocampus, where Zn2+ is found in abundance.	Zinc	48-52	potassium voltage-gated channel subfamily A member 4	Homo sapiens	38-44
8450837-7	1993	The resulting modulation of gating of hKv1.4 by Zn2+ may well be of physiological significance, in view of the localization of this channel in mossy fiber nerve terminals in the hippocampus, where Zn2+ is found in abundance.	Zinc	197-201	potassium voltage-gated channel subfamily A member 4	Homo sapiens	38-44
1447834-12	1992	The inhibitory effect of Cd on somatomedin activity via Zn was suggested.	Zinc	56-58	insulin-like growth factor 1	Rattus norvegicus	31-42
1617680-6	1992	Moreover, in these clones H-2Kb expression could be enhanced in the presence of Zn2+, indicating that the metallothionein enhancer was functioning properly.	Zinc	80-84	histocompatibility 2, K1, K region	Mus musculus	26-31
1346974-8	1992	Here we report that 5-CLA-modified PBGS (5-CLA-PBGS) can bind up to four substrate molecules and four Zn(II) ions.	Zinc	102-104	selectin P ligand	Homo sapiens	22-25
1346974-8	1992	Here we report that 5-CLA-modified PBGS (5-CLA-PBGS) can bind up to four substrate molecules and four Zn(II) ions.	Zinc	102-104	selectin P ligand	Homo sapiens	43-46
1346974-10	1992	On the basis of the dissociation constants, the metal ion binding sites lost upon 5-CLA modification are assigned to the four catalytic Zn(II) sites.	Zinc	136-142	selectin P ligand	Homo sapiens	84-87
1352630-1	1992	The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated.	Zinc	27-31	carbonic anhydrase 1	Rattus norvegicus	163-166
1515035-2	1992	The relative stabilities of the various metal-bound states of alpha-LA to trypsin and chymotrypsin at 37 and 5 degrees C decrease in the following order: Ca(II)-alpha-LA greater than Zn(II), Ca(II)-alpha-LA greater than apo-alpha-LA.	Zinc	183-185	lactalbumin alpha	Bos taurus	62-70
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	24-30	lactalbumin alpha	Bos taurus	61-69
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	24-30	lactalbumin alpha	Bos taurus	238-246
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	188-194	lactalbumin alpha	Bos taurus	61-69
1515035-4	1992	Occupation of the first Zn(II)-binding site in Ca(II)-loaded alpha-LA slightly alters the HPLC digestion patterns at both temperatures and accelerates the digestion at 37 degrees C due to Zn(II)-induced shift of the thermal transition of alpha-LA, exposing some portion of thermally denatured protein.	Zinc	188-194	lactalbumin alpha	Bos taurus	238-246
31172523-7	2019	Further, the dissolution of Zn2+ in the solution was analyzed and determined to be 0.199 mug mL-1 .	Zinc	28-32	L1 cell adhesion molecule	Mus musculus	93-97
1544874-3	1992	Commitment assay indicated that elevated levels of c-Myc interfere with entry of the transformant into the commitment event, but when c-myc expression was reduced by removing Zn ions from the medium, the cells could reenter the commitment program.	Zinc	175-177	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	134-139
1657901-3	1991	The PPi-ase activity of the enzyme can be inhibited by cadmium ions (Cd2+), perhaps by replacing Zn2+ from the active site of the enzyme molecule.	Zinc	97-101	CD2 molecule	Homo sapiens	69-72
31394124-8	2019	However, the inhibitive effects of Zn supplementation were significantly blocked after double knockdown of MT-1 and MT-2 by using Small Interfering RNA (siRNA) Transfection method.	Zinc	35-37	metallothionein-1	Canis lupus familiaris	107-111
30941734-6	2019	It appears that cells of the immature cortex express a wide diversity of actors involved in Zn homeostasis with Zip7, SOD1, and metallothioneins being the most abundant transcripts throughout corticogenesis.	Zinc	92-94	solute carrier family 39 (zinc transporter), member 7	Mus musculus	112-116
31521203-3	2019	Uptake of ZIP8-mediated Mn2+, Zn2+, Fe2+, Se4+, and Co2+ represents endogenous functions-moving these cations into the cell.	Zinc	30-34	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	10-14
31345348-7	2019	Multiple regression analyses revealed that DNA methylation of LINE1, Nrf2, OGG1, and PARP1 was associated with potentially toxic (As, Hg, Mn, Mo, and Pb) and essential (Cu, Se, and Zn) elements, and with their interactions.	Zinc	181-183	8-oxoguanine DNA glycosylase	Homo sapiens	75-79
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	146-148	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	123-128
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	171-173	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	123-128
31346193-3	2019	Here we report our findings that Zn transporter ZnT2 is required for the release of Zn from mast cells.	Zinc	33-35	solute carrier family 30 (zinc transporter), member 2	Mus musculus	48-52
31244122-2	2019	In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H   O.	Zinc	50-54	complement C2	Homo sapiens	64-71
31146164-5	2019	Activation of ZnR/GPR39 by Zn2+ upregulated K+/Cl- co-transport activity, measured using NH4+ as a surrogate to K+ while monitoring intracellular pH.	Zinc	27-31	G protein-coupled receptor 39	Homo sapiens	18-23
31146164-10	2019	Importantly, silencing of either ZnR/GPR39 or KCC3 attenuated Zn2+-dependent scratch closure.	Zinc	62-66	G protein-coupled receptor 39	Homo sapiens	37-42
31146164-11	2019	Thus, a novel link between KCC3 and Zn2+, via ZnR/GPR39, promotes breast cancer cell migration and proliferation.	Zinc	36-40	G protein-coupled receptor 39	Homo sapiens	50-55
31253848-5	2019	Additionally, while we were unable to verify the presence of synaptic Zn2+ in these cultures, we did detect the synaptic vesicle Zn2+ transporter ZnT3 and found it to be substantially upregulated by cytosolic Zn2+ increases.	Zinc	129-133	solute carrier family 30 member 3	Rattus norvegicus	146-150
31026140-7	2019	The Zn-air battery assembled with SMO@NrGO shows a high discharge peak power density of 244 mW cm-2 and superior cycling stability against noble metals.	Zinc	4-6	smoothened, frizzled class receptor	Homo sapiens	34-37
30690405-4	2019	Firstly, Zn pre-exposure increased MTs and HSP70 levels and CAT activity in Cd-free water, which may facilitate fish quick response to Cd.	Zinc	9-11	heat shock protein 8-like	Danio rerio	43-48
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	heat shock transcription factor 1	Danio rerio	67-71
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	nfe2 like bZIP transcription factor 2a	Danio rerio	94-98
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	heat shock protein 8-like	Danio rerio	135-140
30668786-11	2019	In the jejunum, organic Zn fed birds showed a downregulation of expression of IL-8 (P = 0.02), and upregulation of IL-10 (P = 0.05) in CoCPF birds vs. ZnSO4- CoCPF birds.	Zinc	24-26	interleukin 10	Gallus gallus	115-120
30714183-5	2019	METHODS: PC3 and DU145 cells were treated with different concentrations of Zn and/or PTX.	Zinc	75-77	proprotein convertase subtilisin/kexin type 1	Homo sapiens	9-12
30786955-7	2019	Together, the results indicate that the Hps1 and Ap3b1 genes play distinct roles in male reproductive system development and spermatogenesis in mice, even though ep and pe males share common phenotypes, including reduced lysosomes in Sertoli cells and dislocated Zn2+ in sperm heads.	Zinc	263-267	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	Mus musculus	40-44
1713475-7	1991	Based on the abilities of nonradioactive metal ions to compete with 65Zn2+ for binding to TFIIIA on Western blots, the relative affinities of the metals for TFIIIA were ranked as follows: Zn2+ = Cu2+ greater than or equal to Hg2+ greater than Cd2+ greater than Co2+ greater than or equal to Ni2+.	Zinc	70-74	general transcription factor 3A L homeolog	Xenopus laevis	90-96
1713475-7	1991	Based on the abilities of nonradioactive metal ions to compete with 65Zn2+ for binding to TFIIIA on Western blots, the relative affinities of the metals for TFIIIA were ranked as follows: Zn2+ = Cu2+ greater than or equal to Hg2+ greater than Cd2+ greater than Co2+ greater than or equal to Ni2+.	Zinc	70-74	general transcription factor 3A L homeolog	Xenopus laevis	157-163
1848338-1	1991	The effects of the potent delta opioid agonist (D-Pen2, D-Pen5)enkephalin (DPDPE) were studied on the endogenous levels and regional distribution of Zn2+ in rat central nervous system by means of flame atomic absorption spectrophotometry.	Zinc	149-153	proenkephalin	Rattus norvegicus	63-73
30698189-6	2019	Although the crystal structures of Cd2+/Zn2+ complexes with EGTQ and BAPTQ derivatives reveal the formation of multiple components including mononuclear and dinuclear complexes, the dinuclear Cd2+ and Zn2+ complexes with a linearly extended structure are regarded as possible fluorescent species in the solution.	Zinc	40-44	CD2 molecule	Homo sapiens	35-38
30698189-6	2019	Although the crystal structures of Cd2+/Zn2+ complexes with EGTQ and BAPTQ derivatives reveal the formation of multiple components including mononuclear and dinuclear complexes, the dinuclear Cd2+ and Zn2+ complexes with a linearly extended structure are regarded as possible fluorescent species in the solution.	Zinc	40-44	CD2 molecule	Homo sapiens	192-195
30698189-6	2019	Although the crystal structures of Cd2+/Zn2+ complexes with EGTQ and BAPTQ derivatives reveal the formation of multiple components including mononuclear and dinuclear complexes, the dinuclear Cd2+ and Zn2+ complexes with a linearly extended structure are regarded as possible fluorescent species in the solution.	Zinc	201-205	CD2 molecule	Homo sapiens	35-38
30785438-2	2019	Notably, through doping Zn ions with a transition metal, in this work, we fabricated a bimetallic ZnM-ZIF (M = Ni, Cu, or Co)-encapsulated CdS nanorod heterostructure for the first time.	Zinc	24-26	CDP-diacylglycerol synthase 1	Homo sapiens	139-142
30932415-5	2019	RESULTS: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT.	Zinc	105-107	lactotransferrin	Rattus norvegicus	29-31
30649352-16	2019	Supplemental Cr in diets containing 90 mg of supplemental Zn/kg DM from ZH improved final BW, ADG, and hot carcass weights.	Zinc	58-60	ADG	Bos taurus	94-97
30564965-5	2019	The increased glycosylation of alpha2M was accompanied by reduced binding of Zn ions and insulin-like growth factor-binding protein 2 (IGFBP-2).	Zinc	77-79	alpha-2-macroglobulin	Homo sapiens	31-38
30564965-6	2019	Glycosylation of alpha2M and its reactivity with IGFBP-2 is similarly affected by ageing and incidence of colon cancer, but the reactivity of alpha2M with Zn ions is differently affected, as the binding of Zn ions remains unaltered in patients with colon cancer compared to healthy middle-aged individuals.	Zinc	155-157	alpha-2-macroglobulin	Homo sapiens	142-149
30564965-6	2019	Glycosylation of alpha2M and its reactivity with IGFBP-2 is similarly affected by ageing and incidence of colon cancer, but the reactivity of alpha2M with Zn ions is differently affected, as the binding of Zn ions remains unaltered in patients with colon cancer compared to healthy middle-aged individuals.	Zinc	206-208	alpha-2-macroglobulin	Homo sapiens	17-24
30465671-7	2019	Most studies investigating the relationship of Cu, Fe and Zn with alpha-synuclein have relied on the use of recombinant protein and there is little evidence that the interaction between metals and alpha-synuclein are physiologically relevant.	Zinc	58-60	synuclein alpha	Homo sapiens	66-81
30465671-9	2019	In addition, we examined the ability of dityrosine cross-linked alpha-synuclein oligomers to bind Cu, Fe and Zn.	Zinc	109-111	synuclein alpha	Homo sapiens	64-79
31544812-4	2019	Human IgG and its Fab domain coated on microtiter plate wells recognized biotin-labeled PPIX and its derivatives, Fe-PPIX and Zn-PPIX, whereas the Fc domain showed some extent of reaction only with Zn-PPIX.	Zinc	126-128	FA complementation group B	Homo sapiens	18-21
30278349-7	2019	CO2/O2 ratio highly affected the capture of Cr and Zn but had no influence on Al, and the decrease of CO2/O2 ratio would help capturing Cr and Zn.	Zinc	51-53	complement C2	Homo sapiens	0-6
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	nfe2 like bZIP transcription factor 2a	Danio rerio	97-101
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	heat shock transcription factor 1	Danio rerio	114-118
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	heat shock protein 8-like	Danio rerio	120-125
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	148-157
32254894-4	2018	The binding peptides are conjugated on the surface of CdSe/ZnS quantum dots (QDs) and consequently acted as a ligand that specifically targets MT3-MMP overexpressed tumor cells.	Zinc	59-62	matrix metallopeptidase 16	Homo sapiens	143-150
1703164-2	1990	The uptake of alpha 2-macroglobulin, a major serum Zn-binding protein proposed to have a function in Zn transport, was less than 1/200 that of the Zn uptake rate.	Zinc	51-53	alpha-2-macroglobulin	Homo sapiens	14-35
30079968-1	2018	Late 3d transition metal disulfides (MS2 , M=Fe, Co, Ni, Cu, Zn) can crystallize in an interesting cubic-pyrite structure, in which all the metal cations are in a low-spin electronic configuration with progressive increase of the eg electrons for M=Fe-Zn.	Zinc	61-63	MS2	Homo sapiens	37-40
1703164-2	1990	The uptake of alpha 2-macroglobulin, a major serum Zn-binding protein proposed to have a function in Zn transport, was less than 1/200 that of the Zn uptake rate.	Zinc	101-103	alpha-2-macroglobulin	Homo sapiens	14-35
2134465-1	1990	Some physicochemical entities involved in the facilitated transport of oxygen along a transport path z1 less than or equal to z less than or equal to zn with membranes impermeable to myoglobin at zi, i = 1,...,n, were identified in an earlier paper [Math.	Zinc	150-152	myoglobin	Homo sapiens	183-192
28884360-8	2018	The mix of Ca, Zn and Fe increased DMT1 and ferroportin expression mainly under high Zn concentration.	Zinc	15-17	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
28884360-8	2018	The mix of Ca, Zn and Fe increased DMT1 and ferroportin expression mainly under high Zn concentration.	Zinc	85-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
2118207-3	1990	Release of Gd3+ from the complex is responsible for the toxicity associated with gadolinium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo.	Zinc	147-151	GRDX	Homo sapiens	11-14
30533266-6	2018	Furthermore, GAS co- or pre-treatment markedly suppressed Zn2+-induced cell death caused by excessive ROS production and PARP-1 induction.	Zinc	58-62	poly (ADP-ribose) polymerase 1	Rattus norvegicus	121-127
30533266-7	2018	We found that GAS suppressed p67 expression and PAR formation in astrocytes, which might underlie the anti- Zn2+-toxicity and anti-oxidative effects of GAS in astrocytes.	Zinc	108-112	methionyl aminopeptidase 2	Rattus norvegicus	29-32
33945057-6	2022	Compared with the index CHM, the results of the new analysis of contaminated soils with the ATM fraction demonstrated that the Zn content in Calcaric Fluvic Arenosol is decreased considerably due to its low buffer capacity.	Zinc	127-129	ATM serine/threonine kinase	Homo sapiens	92-95
30234868-0	2018	Ultrastability and color-tunability of CsPb(Br/I)3 nanocrystals in P-Si-Zn glass for white LEDs.	Zinc	72-74	granzyme B	Homo sapiens	39-43
33776569-2	2021	The aim of this study was to evaluate the effects of Zn supplementation on serum copper (Cu) to Zn and C-reactive protein (CRP) to albumin ratios (CAR) in HD patients.	Zinc	53-55	CXADR pseudogene 1	Homo sapiens	147-150
33776569-9	2021	In parallel, serum albumin concentrations significantly increased, and CAR decreased in Zn supplemented group only.	Zinc	88-90	CXADR pseudogene 1	Homo sapiens	71-74
30239541-4	2018	The results reported herein from density functional theory (M05-2X) and ab initio (MP2 and CCSD(T)) calculations demonstrate that both the coordination number and the molecular geometry have a sizable impact on the binding strength, deprotonation energy, and acidity of the Zn(ii) coordinated water.	Zinc	274-276	tryptase pseudogene 1	Homo sapiens	83-86
7843095-3	1994	Zn2+ and Cu2+ competitively inhibit Ca2+ release evoked by Cd2+ without affecting Ca2+ release by hormones such as bradykinin.	Zinc	0-4	CD2 molecule	Homo sapiens	59-62
29927321-1	2018	Zrt/Irt-like protein 8 (ZIP8) (encoded by Slc39a8) is a multifunctional membrane transporter that influxes essential metal cations Zn2+, Mn2+, Fe2+, and nonmetal inorganic selenite (HSeO3-).	Zinc	131-135	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-22
34897851-1	2022	An investigation of pulsed-laser-ablated Zn, Cd and Hg metal atom reactions with HCN under excess argon during co-deposition with laser-ablated Hg atoms from a dental amalgam target also provided Hg emissions capable of photoionization of the CN photo-dissociation product.	Zinc	41-43	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	81-84
29927321-1	2018	Zrt/Irt-like protein 8 (ZIP8) (encoded by Slc39a8) is a multifunctional membrane transporter that influxes essential metal cations Zn2+, Mn2+, Fe2+, and nonmetal inorganic selenite (HSeO3-).	Zinc	131-135	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	24-28
29927321-1	2018	Zrt/Irt-like protein 8 (ZIP8) (encoded by Slc39a8) is a multifunctional membrane transporter that influxes essential metal cations Zn2+, Mn2+, Fe2+, and nonmetal inorganic selenite (HSeO3-).	Zinc	131-135	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	42-49
29936635-1	2018	KEY MESSAGE: Cysteine in the N-terminal metal-binding domain (N-MBD) of TaHMA2 participates in Zn2+/Cd2+ binding and translocation in Arabidopsis.	Zinc	95-99	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	72-78
34492472-2	2022	The SEM and GCD tests indicate that the pre-ionization process of BTC greatly accelerates the reaction speed between BTC and Zn ions, and only 0.5 h is required for the preparation of Zn-MOF with orderly morphology at room temperature, far less than 3-24 h of the existing hydrothermal synthesis.	Zinc	125-127	guanylate cyclase 2E, pseudogene	Homo sapiens	12-15
29936635-2	2018	Wheat heavy metal ATPase 2 (TaHMA2) can transport Zn2+ and Cd2+ across membranes.	Zinc	50-54	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	18-26
29936635-2	2018	Wheat heavy metal ATPase 2 (TaHMA2) can transport Zn2+ and Cd2+ across membranes.	Zinc	50-54	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	28-34
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	Zinc	76-78	Cbl proto-oncogene	Homo sapiens	72-75
29936635-7	2018	The plants with a truncated N/C-terminal of TaHMA2 were impaired in Zn2+/Cd2+ tolerance and translocation, while mutagenesis of Cys in the N-MBD reduced the tolerance and transport activity of TaHMA2, suggesting the involvement of Cys in Zn2+/Cd2+ binding and translocation in Arabidopsis.	Zinc	68-72	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	44-50
29936635-7	2018	The plants with a truncated N/C-terminal of TaHMA2 were impaired in Zn2+/Cd2+ tolerance and translocation, while mutagenesis of Cys in the N-MBD reduced the tolerance and transport activity of TaHMA2, suggesting the involvement of Cys in Zn2+/Cd2+ binding and translocation in Arabidopsis.	Zinc	238-242	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	44-50
29936635-7	2018	The plants with a truncated N/C-terminal of TaHMA2 were impaired in Zn2+/Cd2+ tolerance and translocation, while mutagenesis of Cys in the N-MBD reduced the tolerance and transport activity of TaHMA2, suggesting the involvement of Cys in Zn2+/Cd2+ binding and translocation in Arabidopsis.	Zinc	238-242	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	193-199
34832131-0	2021	Incorporation of Au Nanoparticles on ZnO/ZnS Core Shell Nanostructures for UV Light/Hydrogen Gas Dual Sensing Enhancement.	Zinc	41-44	gastrin	Homo sapiens	93-96
32255071-6	2018	The fluorescence ratios (I570/I450) of SiNPs@GSH-AuNCs are positively correlated with Zn2+ or Cd2+ with the linear range from 1.5 muM to 500 muM.	Zinc	86-90	CD2 molecule	Homo sapiens	94-97
34832131-1	2021	ZnO/ZnS nanocomposite-based nanostructures exhibit dual light and gas sensing capabilities.	Zinc	4-7	gastrin	Homo sapiens	66-69
34528410-1	2021	The effective path to synthesize Zn x Cd 1-x S quantum dots (ZCS QDs) in aqueous phase at room temperature have remained relatively unexplored.	Zinc	33-35	CD1b molecule	Homo sapiens	38-42
34740311-4	2022	We showed that due to its lysosomotropic properties, GNS561 could reach and specifically inhibited its enzyme target, PPT1 (palmitoyl-protein thioesterase 1), resulting in lysosomal unbound Zn2+ accumulation, impairment of cathepsin activity, blockage of autophagic flux, altered location of MTOR (mechanistic target of rapamycin kinase), lysosomal membrane permeabilization, caspase activation and cell death.	Zinc	190-194	palmitoyl-protein thioesterase 1	Homo sapiens	118-122
34740311-4	2022	We showed that due to its lysosomotropic properties, GNS561 could reach and specifically inhibited its enzyme target, PPT1 (palmitoyl-protein thioesterase 1), resulting in lysosomal unbound Zn2+ accumulation, impairment of cathepsin activity, blockage of autophagic flux, altered location of MTOR (mechanistic target of rapamycin kinase), lysosomal membrane permeabilization, caspase activation and cell death.	Zinc	190-194	palmitoyl-protein thioesterase 1	Homo sapiens	124-156
34627839-11	2021	Together, our data indicate that TRPM7 regulates cellular levels of MDMX in part by modulating the intracellular Zn2+ concentration to promote tumorigenesis.	Zinc	113-117	MDM4 regulator of p53	Homo sapiens	68-72
34549997-13	2021	Here, we use the innate immune protein calprotectin (CP), which complexes with several metals, including iron (Fe), zinc (Zn), and manganese (Mn), and the opportunistic pathogen Pseudomonas aeruginosa to investigate multimetal starvation.	Zinc	122-124	ceruloplasmin	Homo sapiens	39-51
34636529-2	2021	At process times above 150 s, the oversupplied KF agglomerated into large islands and was subsequently eliminated during the deposition of the chemical bath deposition (CBD)-Zn(O,S) buffer layer owing to the islands" water-soluble characteristics.	Zinc	174-176	arylformamidase	Homo sapiens	47-49
30047045-0	2018	Thiacalix[4]arenes Remove the Inhibitory Effects of Zn Cations on the Myosin ATPase Activity.	Zinc	52-54	myosin heavy chain 14	Homo sapiens	70-76
30047045-4	2018	The study of 0.5-5 mM Zn2+ effect on myosin S1 ATPase activity from the uterus found that 5 mM Zn2+ cations have the most pronounced inhibitory effect.	Zinc	22-26	myosin heavy chain 14	Homo sapiens	37-43
30047045-4	2018	The study of 0.5-5 mM Zn2+ effect on myosin S1 ATPase activity from the uterus found that 5 mM Zn2+ cations have the most pronounced inhibitory effect.	Zinc	95-99	myosin heavy chain 14	Homo sapiens	37-43
30047045-5	2018	The calculation of the kinetic parameters (Km and Vmax, ATP) revealed that the apparent maximum velocity of the hydrolysis ATP catalyzed by myosin in the presence of 5 mM Zn2+ decreased by 1.6 times.	Zinc	171-175	myosin heavy chain 14	Homo sapiens	140-146
30047045-6	2018	The value of Km for ATP hydrolysis by myosin S1 in the presence of Zn2+ does not change statistically, although it tends to decrease.	Zinc	67-71	myosin heavy chain 14	Homo sapiens	38-44
30047045-8	2018	Also, it was demonstrated that tetrahydroxythiacalix[4]arene-tetrasulfosphonate (C-798) and tetrahydroxythiacalix[4]arene-tetraphosphonate (C-800) restored myosin S1 ATPase activity to the control level in the presence of 5 mM Zn2+.	Zinc	227-231	myosin heavy chain 14	Homo sapiens	156-162
30047045-10	2018	The molecular docking of C-798 and C-800 into the myosin S1 region showed that these thiacalix[4]arenes could interact with Zn cation bond by myosin amino acid residues near the ATPase active site.	Zinc	124-126	myosin heavy chain 14	Homo sapiens	50-56
30047045-10	2018	The molecular docking of C-798 and C-800 into the myosin S1 region showed that these thiacalix[4]arenes could interact with Zn cation bond by myosin amino acid residues near the ATPase active site.	Zinc	124-126	myosin heavy chain 14	Homo sapiens	142-148
29751173-3	2018	Pb and Zn are quantitively identified to be still emitted from ALBP soil, and Cd as well As are from agricultural activity.	Zinc	7-9	fatty acid binding protein 4	Homo sapiens	63-67
29198021-10	2018	Zn exposure substantially reduced UPS-associated trypsin-like, chymotrypsin-like, and caspase-like activities along with the expression of SUG1 and beta-5 subunits of UPS in the nigrostriatal tissues of exposed groups.	Zinc	0-2	proteasome 26S subunit, ATPase 5	Rattus norvegicus	139-143
34636529-3	2021	As a result, the growth mechanism of the CBD-Zn(O,S) layer varied as a function of KF PDT process time.	Zinc	45-47	arylformamidase	Homo sapiens	83-85
34686351-2	2021	Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca2+ and Zn2+ release channel that regulates multiple aspects of lysosome function, is dramatically upregulated in metastatic melanoma cells compared with normal cells.	Zinc	76-80	mucolipin 1	Mus musculus	46-52
34586565-2	2021	GPR39 is a GPCR which can interact with Zn and modulate the colonocytes" survival.	Zinc	40-42	G protein-coupled receptor 39	Homo sapiens	0-5
29912588-8	2018	Zn-induced autophagy and lipid turnover involved up-regulation of the calcium/calmodulin-dependent protein kinase kinase-beta (Ca2+/CaMKKbeta)/AMPK pathway.	Zinc	0-2	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	132-141
29912588-9	2018	Meanwhile, Zn2+-activated autophagy and lipid depletion were via enhancing metal response element-binding transcription factor (MTF)-1 DNA binding at PPARalpha promoter region, which in turn induced transcriptional activation of the key genes related to autophagy and lipolysis.	Zinc	11-15	peroxisome proliferator activated receptor alpha	Homo sapiens	150-159
29912588-10	2018	Zn activated the pathways of Zn2+/MTF-1/ Peroxisome proliferator-activated receptor (PPAR)alpha and Ca2+/CaMKKbeta/AMPK, resulting in the up-regulation of lipophagy and accordingly reduced hepatic lipid accumulation.	Zinc	0-2	peroxisome proliferator activated receptor alpha	Homo sapiens	85-95
29912588-10	2018	Zn activated the pathways of Zn2+/MTF-1/ Peroxisome proliferator-activated receptor (PPAR)alpha and Ca2+/CaMKKbeta/AMPK, resulting in the up-regulation of lipophagy and accordingly reduced hepatic lipid accumulation.	Zinc	0-2	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	105-114
29912588-12	2018	The present study also indicated the novel mechanism for Zn-induced lipolysis by the activation of Zn2+/MTF-1/PPARalpha and Ca2+/CaMKKbeta/AMPK pathways, which induced the occurrence of lipophagy.	Zinc	57-59	peroxisome proliferator activated receptor alpha	Homo sapiens	110-119
29912588-12	2018	The present study also indicated the novel mechanism for Zn-induced lipolysis by the activation of Zn2+/MTF-1/PPARalpha and Ca2+/CaMKKbeta/AMPK pathways, which induced the occurrence of lipophagy.	Zinc	57-59	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	129-138
34581906-2	2021	Since mitochondrial Zn2+ may control mitophagy by regulating mitochondrial membrane potential (MMP), we hypothesized that the zinc transporter ZIP7 that controls Zn2+ levels within mitochondria would contribute to reperfusion injury by regulating mitophagy.	Zinc	20-24	solute carrier family 39 (zinc transporter), member 7	Mus musculus	143-147
29788717-4	2018	Through sequential partial exchange of Cu+ in Cu1.8S nanocrystals with Zn2+ and Cd2+, five distinct ZnS/CdS/Cu1.8S nanosphere and nanorod isomers are accessible.	Zinc	100-103	CDP-diacylglycerol synthase 1	Homo sapiens	104-107
29119272-9	2018	Homology modeling of the structure of the budding yeast Nse1-Nse3 heterodimer based on the human Nse1-MAGEG1 structure suggests a similar organization and indicates that perturbation of the Zn-coordinating cluster has the potential to allosterically alter structural elements at the Nse1/Nse3 interaction interface that may abrogate their association.	Zinc	190-192	Smc5-Smc6 complex subunit NSE3	Saccharomyces cerevisiae S288C	61-65
29746104-1	2018	Nickel (Ni), cobalt (Co), and zinc (Zn) loaded on fibrous silica KCC-1 was investigated for CO2 methanation reactions.	Zinc	36-38	solute carrier family 12 member 4	Homo sapiens	65-70
29746104-2	2018	Ni/KCC-1 exhibits the highest catalyst performance with a CH4 formation rate of 33.02 x 10-2 molCH4 molmetal-1 s-1, 1.77 times higher than that of Co/KCC-1 followed by Zn/KCC-1 and finally the parent KCC-1.	Zinc	168-170	solute carrier family 12 member 4	Homo sapiens	3-8
29658693-7	2018	The interaction between zinc finger peptide and Zn2+ was firstly applied in SERS sensor for the sensitive detection of PSA.	Zinc	48-52	kallikrein related peptidase 3	Homo sapiens	119-122
29548726-6	2018	Under Cd exposure, we noted an overexpression of the genes coding for membrane transporter involved in the intracellular incorporation of Zn (ZIP6) associated with inhibition of that encoding the transporters involved in the output of the Zn into the extracellular medium (ZnT1 and ZnT3).	Zinc	138-140	solute carrier family 30 member 1	Rattus norvegicus	273-277
29548726-6	2018	Under Cd exposure, we noted an overexpression of the genes coding for membrane transporter involved in the intracellular incorporation of Zn (ZIP6) associated with inhibition of that encoding the transporters involved in the output of the Zn into the extracellular medium (ZnT1 and ZnT3).	Zinc	138-140	solute carrier family 30 member 3	Rattus norvegicus	282-286
29561927-4	2018	Recent discoveries indicate that Zn(ii) ions are bound with MT2 with the range from nano- to picomolar affinity, which determines its cellular zinc buffering properties that are demonstrated by the presence of partially Zn(ii)-depleted MT2 species.	Zinc	33-39	metallothionein 2A	Homo sapiens	60-63
29561927-4	2018	Recent discoveries indicate that Zn(ii) ions are bound with MT2 with the range from nano- to picomolar affinity, which determines its cellular zinc buffering properties that are demonstrated by the presence of partially Zn(ii)-depleted MT2 species.	Zinc	33-39	metallothionein 2A	Homo sapiens	236-239
29561927-4	2018	Recent discoveries indicate that Zn(ii) ions are bound with MT2 with the range from nano- to picomolar affinity, which determines its cellular zinc buffering properties that are demonstrated by the presence of partially Zn(ii)-depleted MT2 species.	Zinc	220-226	metallothionein 2A	Homo sapiens	60-63
29561927-7	2018	Here, we describe the Zn(ii) binding mechanism in human MT2 with high resolution with respect to particular Zn(ii) binding sites, and provide structural insights into Zn(ii)-depleted MT species.	Zinc	22-28	metallothionein 2A	Homo sapiens	56-59
29561927-7	2018	Here, we describe the Zn(ii) binding mechanism in human MT2 with high resolution with respect to particular Zn(ii) binding sites, and provide structural insights into Zn(ii)-depleted MT species.	Zinc	108-114	metallothionein 2A	Homo sapiens	56-59
29561927-7	2018	Here, we describe the Zn(ii) binding mechanism in human MT2 with high resolution with respect to particular Zn(ii) binding sites, and provide structural insights into Zn(ii)-depleted MT species.	Zinc	108-114	metallothionein 2A	Homo sapiens	56-59
29938179-6	2018	Additionally, guest molecules (e.g., glutamate dehydrogenase, GDH) can be encapsulated within the hierarchical Cys/Zn framework, which facilitates sustainable photoenzymatic synthesis of glutamate.	Zinc	115-117	glutamate dehydrogenase 1	Homo sapiens	62-65
29544683-7	2018	Erythrocyte adhesion to endothelial cells was also significantly increased after Zn2+ stimulation, and this effect was inhibited by HRG.	Zinc	81-85	histidine-rich glycoprotein	Mus musculus	132-135
29473882-7	2018	Unexpectedly, it has been found that Trp1 contains a couple of Zn(II) at the active site.	Zinc	63-69	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	37-41
29435667-1	2018	BACKGROUND: The coexistence of Cd2+ and Zn2+ ions in nature has a significant influence on their environmental behaviors in soils and bioavailability for plants.	Zinc	40-44	CD2 molecule	Homo sapiens	31-34
29435667-7	2018	A 1:1 ratio of Cd2+ to Zn2+ promotes the mutual inhibition of their retentions.	Zinc	23-27	CD2 molecule	Homo sapiens	15-18
29435667-11	2018	In the combined system, Cd2+ and Zn2+ restrain each other, resulting in the weaker binding force between ions and soil particles at a 1:1 ratio of Cd2+-Zn2+.	Zinc	33-37	CD2 molecule	Homo sapiens	147-150
29435667-11	2018	In the combined system, Cd2+ and Zn2+ restrain each other, resulting in the weaker binding force between ions and soil particles at a 1:1 ratio of Cd2+-Zn2+.	Zinc	152-156	CD2 molecule	Homo sapiens	24-27
29435667-11	2018	In the combined system, Cd2+ and Zn2+ restrain each other, resulting in the weaker binding force between ions and soil particles at a 1:1 ratio of Cd2+-Zn2+.	Zinc	152-156	CD2 molecule	Homo sapiens	147-150
28939557-2	2018	We previously identified some zinc(II) chelators, including 8-quinolinol derivatives, that suppress apoptosis in attempts to discover compounds that target the zinc-binding site in p53.	Zinc	30-38	transformation related protein 53	Mus musculus	181-184
34581906-2	2021	Since mitochondrial Zn2+ may control mitophagy by regulating mitochondrial membrane potential (MMP), we hypothesized that the zinc transporter ZIP7 that controls Zn2+ levels within mitochondria would contribute to reperfusion injury by regulating mitophagy.	Zinc	162-166	solute carrier family 39 (zinc transporter), member 7	Mus musculus	143-147
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	76-80	solute carrier family 39 (zinc transporter), member 7	Mus musculus	7-11
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	76-80	solute carrier family 39 (zinc transporter), member 7	Mus musculus	202-206
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	182-186	solute carrier family 39 (zinc transporter), member 7	Mus musculus	7-11
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	182-186	PTEN induced putative kinase 1	Mus musculus	102-107
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	182-186	solute carrier family 39 (zinc transporter), member 7	Mus musculus	202-206
34581906-12	2021	cKO of ZIP7 led to mitochondrial depolarization by increasing mitochondrial Zn2+ and, accumulation of PINK1 and Parkin in mitochondria, suggesting that the decrease in mitochondrial Zn2+ in response to ZIP7 upregulation resulting in mitochondrial hyperpolarization may impede PINK1 and Parkin accumulation in mitochondria.	Zinc	182-186	PTEN induced putative kinase 1	Mus musculus	276-281
34298062-9	2021	Furthermore, Zn2+ reduces GAPR-1 protein degradation, which indicates stabilization of GAPR-1 in inclusions.	Zinc	13-17	GLI pathogenesis related 2	Homo sapiens	26-32
34298062-9	2021	Furthermore, Zn2+ reduces GAPR-1 protein degradation, which indicates stabilization of GAPR-1 in inclusions.	Zinc	13-17	GLI pathogenesis related 2	Homo sapiens	87-93
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	signal transducer and activator of transcription 3	Rattus norvegicus	199-205
34525352-7	2021	Citrate supplementation rescues Huh7 cell viability in response to glutamine deprivation or Zn2+ treatment, and NaCT deficiency mitigates these effects.	Zinc	92-96	solute carrier family 13 member 5	Homo sapiens	112-116
34401540-14	2021	However, Zn supplementation increased (P < 0.05) copper zinc superoxide dismutase (CuZnSOD) activity and metallothionein mRNA expression, and effectively decreased (P < 0.05) the expressions of HSP70 mRNA and protein, as well as HSP90 mRNA.	Zinc	9-11	heat shock protein 90 alpha family class A member 1	Homo sapiens	229-234
34101337-3	2021	The fluorescent behavior of C-1 upon the addition of Zn2+ or Cd2+ showed a "turn-on" response accompanied with fluorescence enhancement at 510 nm by 6 times for Cd2+ and by 13 times for Zn2+ .	Zinc	53-57	CD2 molecule	Homo sapiens	161-164
34101337-3	2021	The fluorescent behavior of C-1 upon the addition of Zn2+ or Cd2+ showed a "turn-on" response accompanied with fluorescence enhancement at 510 nm by 6 times for Cd2+ and by 13 times for Zn2+ .	Zinc	186-190	CD2 molecule	Homo sapiens	61-64
34161607-1	2021	The association behavior of apoferritin species with the anionic porphyrins, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (H2 TPPS4- ) and its zinc(II) complex (ZnTPPS4- ), which are water-soluble even in acidic solutions, was investigated for the first time through UV-vis absorption and fluorescence spectroscopy in order to evaluate a potential ability of apoferritin as a stimuli-responsive molecular capsule.	Zinc	146-154	ferritin heavy chain 1	Homo sapiens	28-39
29251416-1	2018	Herein, Ni and Zn elements are doped simultaneously in MnCO3 and microspheric Mnx Niy Znz CO3 is successfully obtained.	Zinc	15-17	keratin 86	Homo sapiens	78-81
29373588-4	2018	Supplemental organic Zn increased bone Zn and Mg content, serum IGF-1, growth hormone and leptin concentration.	Zinc	21-23	insulin like growth factor 1	Gallus gallus	64-69
29243928-0	2018	A Systematic DFT Study of Some Plausible Zn(II) and Al(III) Interaction Sites in N-Terminally Acetylated alpha-Synuclein.	Zinc	41-43	synuclein alpha	Homo sapiens	105-120
29243928-1	2018	The interactions between the protein alpha-synuclein and the Zn(II) and Al(III) cations at different sites were studied at the M06/6-311+G(d,p)/SMD and the omegaB97X-D/6-311+G(d,p)/SMD levels of theory.	Zinc	61-63	synuclein alpha	Homo sapiens	37-52
29243928-5	2018	Herein, we applied a simple theoretical methodology, which satisfactorily reproduces experimental geometries and energies for complexes of N-terminally acetylated alpha-synuclein with Cu(II), to study Zn(II) and Al(III) complexes at those same sites, as well as at some structurally analogous alternative sites.	Zinc	201-203	synuclein alpha	Homo sapiens	163-178
29492208-6	2018	The ability of Zn2+ to protect against oxidative stress via a HIF1alpha-dependent mechanism was investigated using a HIF1alpha knock-down PC3 model.	Zinc	15-19	chromobox 8	Homo sapiens	138-141
29492208-7	2018	Our results demonstrate that the total Zn2+ concentration in normal PNT1A and PC cells is similar, but PC3 cells contain significantly higher free Zn2+ than PNT1A cells (p &lt; 0.01).	Zinc	147-151	chromobox 8	Homo sapiens	103-106
29492208-9	2018	Exposure to 10 microM Zn2+ over 72 hours significantly reduces PC3 cell proliferation in vitro but not in vivo.	Zinc	22-26	chromobox 8	Homo sapiens	63-66
29492208-10	2018	Zn2+ increases PC3 cell survival up to 2.3-fold under oxidative stress, and this protective effect is not seen in PNT1A cells or in a HIF1alpha-KD PC3 cell model.	Zinc	0-4	chromobox 8	Homo sapiens	15-18
29492208-12	2018	HIF1alpha is an integral component of a Zn2+-dependent protective mechanism present in PC3 cells.	Zinc	40-44	chromobox 8	Homo sapiens	87-90
34161607-1	2021	The association behavior of apoferritin species with the anionic porphyrins, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (H2 TPPS4- ) and its zinc(II) complex (ZnTPPS4- ), which are water-soluble even in acidic solutions, was investigated for the first time through UV-vis absorption and fluorescence spectroscopy in order to evaluate a potential ability of apoferritin as a stimuli-responsive molecular capsule.	Zinc	146-154	ferritin heavy chain 1	Homo sapiens	362-373
34106509-1	2021	MCO 3 (M=Zn, Cd, Hg) engages in a spodium bond with nitrogen-containing bases (HCN, NHCH 2 , NH 3 ) and a pnicogen bond with FH 2 Z (Z=P, As, Sb).	Zinc	9-11	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	79-82
34451746-12	2021	However, in 2015, the concentrations of B, Cu, Fe, and Ni, including Mn and Zn, were higher in both DP 5690 wild-type and Uzbek CRL than in DP 5690 CRL.	Zinc	76-78	interleukin 31 receptor A	Homo sapiens	128-131
34447788-4	2021	Using solution NMR and UV-vis spectroscopy, we found that Cd2+ spontaneously replaced Zn2+ in both structural sites of the C1B domain, with the formation of all-Cd and mixed Zn/Cd protein species.	Zinc	86-90	CD2 molecule	Homo sapiens	58-61
34381781-0	2021	The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm.	Zinc	78-82	cation channel sperm associated 1	Homo sapiens	86-93
34381781-7	2021	Finally, we show that Zn2+ suppresses the action of steroids and prostaglandins on CatSper, which might prevent premature prostaglandin activation of CatSper in the ejaculate, aiding sperm to escape from the ejaculate into the female genital tract.	Zinc	22-26	cation channel sperm associated 1	Homo sapiens	83-90
29675205-1	2018	A [ i-PrPDI]CoBr2 complex (PDI = pyridine-diimine) catalyzes Simmons-Smith-type reductive cyclopropanation reactions using CH2Br2 in combination with Zn.	Zinc	150-152	peptidyl arginine deiminase 1	Homo sapiens	8-11
34381781-7	2021	Finally, we show that Zn2+ suppresses the action of steroids and prostaglandins on CatSper, which might prevent premature prostaglandin activation of CatSper in the ejaculate, aiding sperm to escape from the ejaculate into the female genital tract.	Zinc	22-26	cation channel sperm associated 1	Homo sapiens	150-157
34226580-0	2021	UV-induced Zn:Cd/S quantum dots in-situ formed in the presence of thiols for sensitive and selective fluorescence detection of thiols.	Zinc	11-13	CDP-diacylglycerol synthase 1	Homo sapiens	14-18
29289532-4	2018	Here, we identified a novel connection between CFTR/ENaC expression and the intracellular Zn2+ concentration in the regulation of MUC5AC, a major secreted mucin that is highly expressed in CF airway.	Zinc	90-94	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	130-136
34188447-9	2021	Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays.	Zinc	56-65	butyrylcholinesterase	Homo sapiens	178-199
29218639-3	2018	In this work, we examine two of such His-rich regions from forkhead box and MAFA proteins-MB3 (contains 18 His) and MB6 (with 21 His residues), focusing on the affinity and binding modes of Cu2+ and Zn2+ towards the two His-rich regions.	Zinc	199-203	MAF bZIP transcription factor A	Homo sapiens	76-80
34188447-9	2021	Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays.	Zinc	56-65	butyrylcholinesterase	Homo sapiens	201-205
34927909-0	2021	A Gas-Phase Migration Strategy to Synthesize Atomically Dispersed Mn-N-C Catalysts for Zn-Air Batteries.	Zinc	87-89	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	2-5
28332181-1	2018	In order to verify the effects of exposure to Cd and Zn on testicular DAAM1 gene and protein expression and also to ascertain their involvement in the protective role of Zn in prevent the testicular toxicity Cd-induced in male offspring rats at adult age after gestational and lactational exposure, male offspring rats, from mothers receiving either tap water, Cd, Zn, or Cd + Zn during gestation and lactation periods, were scarified on postnatal days (PND) 70.	Zinc	53-55	dishevelled associated activator of morphogenesis 1	Rattus norvegicus	70-75
28332181-6	2018	Our results imply that Zn could prevent Cd-induced testicular toxicity and sperm quality alteration in adult male rat after gestational and lactational exposure, probably via the restoration of the testicular DAAM1 expression inhibited by Cd.	Zinc	23-25	dishevelled associated activator of morphogenesis 1	Rattus norvegicus	209-214
34065320-8	2021	The established numerical analysis not only helps to find the adequate laser energy input and the optimized shielding gas flow for the LPBF of Zn based metal, but is also beneficial to understand the influence of evaporation on the LPBF process.	Zinc	143-145	gastrin	Homo sapiens	118-121
30097947-0	2018	A Simple Method for Detecting Phosphorylation of Proteins by Using Zn2+-Phos-Tag SDS-PAGE at Neutral pH.	Zinc	67-71	long intergenic non-protein coding RNA 1194	Homo sapiens	77-80
30097947-1	2018	Zn2+-Phos-tag SDS-PAGE at neutral pH is a novel and simple method for analysis and separation of phosphorylated forms of proteins from their nonphosphorylated forms.	Zinc	0-4	long intergenic non-protein coding RNA 1194	Homo sapiens	10-13
30097947-2	2018	This technique exploits the use of a dinuclear metal complex of 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olate which acts as a phosphate-binding tag, having the capacity to incorporate two zinc metal ions which could then bind to phosphomonoester dianion as a bridging ligand.	Zinc	194-204	long intergenic non-protein coding RNA 1194	Homo sapiens	150-153
34066470-6	2021	Enriching the diet with Zn microparticles decreased the Delta6-desaturase activity (p < 0.001).	Zinc	24-26	fatty acid desaturase 2	Rattus norvegicus	62-73
30097947-4	2018	The technique is based on the principle that Zn2+-Phos-tag bound phosphorylated protein has a slower migration rate on the gel as compared to unbound nonphosphorylated proteins and are thus separated on the gel.	Zinc	45-49	long intergenic non-protein coding RNA 1194	Homo sapiens	55-58
30097947-5	2018	Zn2+-Phos-tag SDS-PAGE was developed by improving the Mn2+-Phos-tag SDS-PAGE as the latter was unsuccessful in showing a mobility shift in some proteins such as Tau and pepsin.	Zinc	0-4	long intergenic non-protein coding RNA 1194	Homo sapiens	10-13
30097947-5	2018	Zn2+-Phos-tag SDS-PAGE was developed by improving the Mn2+-Phos-tag SDS-PAGE as the latter was unsuccessful in showing a mobility shift in some proteins such as Tau and pepsin.	Zinc	0-4	long intergenic non-protein coding RNA 1194	Homo sapiens	64-67
30097947-7	2018	Therefore, this Zn2+-Phos-tag SDS-PAGE method is simple, reliable and convenient for phosphate-affinity SDS-PAGE.	Zinc	16-20	long intergenic non-protein coding RNA 1194	Homo sapiens	26-29
29114036-6	2017	Here we found that ZnT2 deletion in lactating mice and cultured MECs resulted in Zn2+-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development.	Zinc	81-85	solute carrier family 30 (zinc transporter), member 2	Mus musculus	19-23
34112355-5	2021	Systemic Zn levels in Alzheimer"s and Parkinson"s disease were found to be reduced, whereas its sequestration in brain may result in modulation of amyloid beta and alpha-synuclein processing with subsequent toxic effects.	Zinc	9-11	synuclein alpha	Homo sapiens	164-179
35176317-6	2022	Specific results of PCA and APCS-MLR suggest that Cu, Zn, Cd, Ba are mainly related to mining activities, Cr and Pb are due to fertilizers and pesticides, and Co and Ni are mainly due to natural sources.	Zinc	54-56	amyloid P component, serum	Homo sapiens	28-32
35158192-6	2022	The optimized ZnS@SnS2/CdS hybrid exhibits a CO generation rate of 155.57 mumol g-1h-1 and an excellent selectivity of 80.4%.	Zinc	14-17	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
35093378-7	2022	The open literature reports that spent adsorbents based on polysaccharides with iron oxides may adsorb up to 1 g g-1 of organic pollutants and up to near 100% of metallic ions from wastewater (Cu2+, Cd2+, Zn2+, Pb2+).	Zinc	205-209	CD2 molecule	Homo sapiens	199-202
29203661-6	2017	We additionally report the ultrahigh-resolution structure of the HDAC6-trichostatin A complex, which reveals two Zn2+-binding conformers for the inhibitor: a major conformer (70%) with canonical bidentate hydroxamate-Zn2+ coordination geometry and a minor conformer (30%) with monodentate hydroxamate-Zn2+ coordination geometry, reflecting a free energy difference of only 0.5 kcal/mol.	Zinc	113-117	histone deacetylase 6	Danio rerio	65-70
29203661-6	2017	We additionally report the ultrahigh-resolution structure of the HDAC6-trichostatin A complex, which reveals two Zn2+-binding conformers for the inhibitor: a major conformer (70%) with canonical bidentate hydroxamate-Zn2+ coordination geometry and a minor conformer (30%) with monodentate hydroxamate-Zn2+ coordination geometry, reflecting a free energy difference of only 0.5 kcal/mol.	Zinc	217-221	histone deacetylase 6	Danio rerio	65-70
29203661-6	2017	We additionally report the ultrahigh-resolution structure of the HDAC6-trichostatin A complex, which reveals two Zn2+-binding conformers for the inhibitor: a major conformer (70%) with canonical bidentate hydroxamate-Zn2+ coordination geometry and a minor conformer (30%) with monodentate hydroxamate-Zn2+ coordination geometry, reflecting a free energy difference of only 0.5 kcal/mol.	Zinc	217-221	histone deacetylase 6	Danio rerio	65-70
35623885-3	2022	In addition, if the ischemic episode is short (and sublethal), there is ongoing Zn2+ accumulation in CA1 mitochondria after OGD that may contribute to their delayed dysfunction.	Zinc	80-84	carbonic anhydrase 1	Mus musculus	101-104
29056506-2	2017	Although the metal-binding center of mouse CN2 is also able to associate with Zn2+in vitro, it was not known whether the zinc form of CN2 has any enzymatic activity.	Zinc	78-82	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	43-46
29180421-5	2017	Moreover, reduced intracellular Zn concentration in Slc39a10fl/fl;LysM-Cre+ macrophages led to the stabilization of p53, which increased apoptosis upon LPS stimulation.	Zinc	32-34	transformation related protein 53, pseudogene	Mus musculus	116-119
35623885-8	2022	Finally, using an in vivo rat (male) asphyxial cardiac arrest (CA) model of transient global ischemia, we found that ~8 min asphyxia induces considerable injury of CA1 neurons 4 hours later that is associated with strong Zn2+ accumulation within many damaged mitochondria.	Zinc	221-225	carbonic anhydrase 1	Rattus norvegicus	164-167
35623885-13	2022	We found progressive and long-lasting mitochondrial Zn2+ accumulation to occur in highly vulnerable CA1 neurons after ischemia.	Zinc	52-56	carbonic anhydrase 1	Rattus norvegicus	100-103
28918363-4	2017	Chronic exposure to Zn accelerated senescence and untreated cells at later passages, where doubling time had increased, displayed relocation of labile Zn and altered expression of genes involved in the response to Zn toxicity, including SLC30A1, SLC39A6, SLC30A5, SLC30A10 and metallothioneins, indicating that senescent cells have altered zinc homeostasis.	Zinc	20-22	solute carrier family 30 member 5	Homo sapiens	255-262
35628299-0	2022	Nitric Oxide Mobilizes Intracellular Zn2+ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation.	Zinc	37-41	protein kinase cGMP-dependent 1	Homo sapiens	58-61
28973586-0	2017	The role of Zn2+, dimerization and N-glycosylation in the interaction of Auxin-Binding Protein 1 (ABP1) with different auxins.	Zinc	12-16	auxin-binding protein 1	Zea mays	73-96
28973586-0	2017	The role of Zn2+, dimerization and N-glycosylation in the interaction of Auxin-Binding Protein 1 (ABP1) with different auxins.	Zinc	12-16	auxin-binding protein 1	Zea mays	98-102
35628299-12	2022	NO stimulated intracellular Zn2+ mobilization in adipocytes through the guanylate cyclase (GC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, and NO-stimulated adipocyte differentiation was Zn2+-dependent.	Zinc	28-32	protein kinase cGMP-dependent 1	Homo sapiens	151-154
35628299-14	2022	In conclusion, NO treatment stimulates intracellular Zn2+ mobilization through the GC/cGMP/PKG pathway, subsequently stimulating adipocyte differentiation.	Zinc	53-57	protein kinase cGMP-dependent 1	Homo sapiens	91-94
35600978-6	2023	We further proved that Zn2+ released from ZnO NPs induced downregulation of beta-catenin expression via HIF-1alpha/BNIP3/LC3B-mediated mitophagy pathway.	Zinc	23-27	catenin beta 1	Homo sapiens	76-88
28505883-4	2017	The Po River fluvial inputs accounted for half of Cr, Ni, Pb and Zn of the fluvial inputs into the western Adriatic Sea, contributing for the delivery of important amounts of Cr and Ni into the sediments, probably related to the natural occurrence of ultramafic rocks in the North sector.	Zinc	65-67	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	116-119
35352424-6	2022	Meanwhile, through in/ex-situ tests, the formation of ZnO layer on the metallic Zn surface inhibits the hydrogen evolution reactions (1.8 mmol h-1 cm-2 ) and passivation during cycling.	Zinc	80-82	H1.5 linker histone, cluster member	Homo sapiens	143-151
28865957-6	2017	This study focused on designing an MT2a construct of recombinant human MT2a to determine the Zn(II) binding profile of MT2a in vitro.	Zinc	93-99	metallothionein 2A	Homo sapiens	35-39
28865957-6	2017	This study focused on designing an MT2a construct of recombinant human MT2a to determine the Zn(II) binding profile of MT2a in vitro.	Zinc	93-99	metallothionein 2A	Homo sapiens	71-75
28865957-6	2017	This study focused on designing an MT2a construct of recombinant human MT2a to determine the Zn(II) binding profile of MT2a in vitro.	Zinc	93-99	metallothionein 2A	Homo sapiens	71-75
28865957-7	2017	We analyzed the pH dependence of Zn-MT2a speciation from electrospray ionization mass spectral data.	Zinc	33-35	metallothionein 2A	Homo sapiens	36-40
28865957-8	2017	At physiological pH, Zn(II) is terminally bound to the cysteine thiols of MT2a, making bead-like structures (non-cooperative metal binding), while at low pH, Zn(II) formed Zn4S11-MT2a clusters involving bridged cysteinyl thiols to the Zn(II) (cooperative metal binding).	Zinc	21-27	metallothionein 2A	Homo sapiens	74-78
28865957-8	2017	At physiological pH, Zn(II) is terminally bound to the cysteine thiols of MT2a, making bead-like structures (non-cooperative metal binding), while at low pH, Zn(II) formed Zn4S11-MT2a clusters involving bridged cysteinyl thiols to the Zn(II) (cooperative metal binding).	Zinc	21-27	metallothionein 2A	Homo sapiens	179-183
28865957-8	2017	At physiological pH, Zn(II) is terminally bound to the cysteine thiols of MT2a, making bead-like structures (non-cooperative metal binding), while at low pH, Zn(II) formed Zn4S11-MT2a clusters involving bridged cysteinyl thiols to the Zn(II) (cooperative metal binding).	Zinc	158-164	metallothionein 2A	Homo sapiens	179-183
35414400-0	2022	A dual-mode immunosensing strategy for prostate specific antigen detection: Integration of resonance Raman scattering and photoluminescence properties of ZnS:Mn2+ nanoprobes.	Zinc	154-157	kallikrein related peptidase 3	Homo sapiens	39-64
28865957-8	2017	At physiological pH, Zn(II) is terminally bound to the cysteine thiols of MT2a, making bead-like structures (non-cooperative metal binding), while at low pH, Zn(II) formed Zn4S11-MT2a clusters involving bridged cysteinyl thiols to the Zn(II) (cooperative metal binding).	Zinc	158-164	metallothionein 2A	Homo sapiens	179-183
28865957-9	2017	The Zn(II) binding profile of MT2a was compared to Zn(II) binding profile of human kidney MT1a, which was reported in literature, and found that the Zn(II) binding profile of MT2a is similar to that of MT1a.	Zinc	4-10	metallothionein 2A	Homo sapiens	30-34
35137187-12	2022	ZmIRT1, ZmIRT2, and ZmYS1 may function in a cooperative manner to maintain Zn and Fe homeostasis in ZmIRT2 overexpressing plants.	Zinc	75-77	iron-phytosiderophore transporter yellow stripe 1	Zea mays	20-25
28865957-9	2017	The Zn(II) binding profile of MT2a was compared to Zn(II) binding profile of human kidney MT1a, which was reported in literature, and found that the Zn(II) binding profile of MT2a is similar to that of MT1a.	Zinc	4-10	metallothionein 2A	Homo sapiens	175-179
28865957-10	2017	The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.	Zinc	69-71	metallothionein 2A	Homo sapiens	73-77
28865957-10	2017	The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.	Zinc	69-71	metallothionein 2A	Homo sapiens	93-97
28865957-10	2017	The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.	Zinc	89-91	metallothionein 2A	Homo sapiens	73-77
28865957-10	2017	The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.	Zinc	89-91	metallothionein 2A	Homo sapiens	93-97
35212861-6	2022	I identify zinc ions (Zn2+) as a serum factor that suppresses proapoptotic signaling in cells expressing HrasG12V.	Zinc	22-26	HRas proto-oncogene, GTPase	Homo sapiens	105-113
35280547-7	2022	Application of various levels of Zn significantly improved the CAT, SOD, POD and ASP activities at 40% WHC compared with control treatment.	Zinc	33-35	catalase-1	Triticum aestivum	63-66
28670856-4	2017	Here we for the first time utilized density functional calculations to guide the application of phosphorene as a high-efficiency metal-free co-catalyst for CdS, Zn0.8 Cd0.2 S or ZnS.	Zinc	161-164	CDP-diacylglycerol synthase 1	Homo sapiens	156-159
28500640-8	2017	Our findings suggest that dysregulation of these key signalling molecules depends upon TSPyV mT antigen interaction with protein phosphatase 2A (PP2A) via intact Zn binding motifs.	Zinc	162-164	protein phosphatase 2 phosphatase activator	Homo sapiens	145-149
35160641-0	2022	Diffusion Bonding of Al-Mg-Si Alloy and 301L Stainless Steel by Friction Stir Lap Welding Using a Zn Interlayer.	Zinc	98-100	LAP	Homo sapiens	78-81
28499166-8	2017	The degradation rates of Zn-xCu alloys in c-SBF solution are quite low, which vary from 22.1+-4.7 to 33.0+-1.0mumyear-1.	Zinc	25-27	chromosome 10 open reading frame 99	Homo sapiens	42-47
28686686-9	2017	Zn2+ induced expression of HIF1alpha and HIF2alpha but not HIF3alpha in HK-2 and ACHN cells.	Zinc	0-4	endothelial PAS domain protein 1	Homo sapiens	41-50
35160641-4	2022	Under the addition of Zn interlayer, the diffusion layer structure at lap interface changed from continuous to uneven and segmented.	Zinc	22-24	LAP	Homo sapiens	70-73
35051078-4	2022	The purpose of our study was to evaluate the mitigative role of excess Zn2+ supply to Cd2+ uptake/translocation and toxicity in clary sage.	Zinc	71-75	CD2 molecule	Homo sapiens	86-89
28434765-0	2017	4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents.	Zinc	50-53	diablo IAP-binding mitochondrial protein	Homo sapiens	36-40
28434765-1	2017	Putative dual action compounds (DACs 3a-d) based on azabicyclo[5.3.0]decane (ABD) Smac mimetic scaffolds linked to Zn2+-chelating 2,2"-dipicolylamine (DPA) through their 4 position are reported and characterized.	Zinc	115-119	diablo IAP-binding mitochondrial protein	Homo sapiens	82-86
35051078-10	2022	Excess Zn2+ ameliorated the adverse effects of Cd2+ on PSII photochemistry, increasing the fraction of energy used for photochemistry (PhiPSII) and restoring PSII redox state and maximum PSII efficiency (Fv/Fm), while decreasing excess excitation energy at PSII (EXC).	Zinc	7-11	CD2 molecule	Homo sapiens	47-50
35051078-11	2022	We conclude that excess Zn2+ application eliminated the adverse effects of Cd2+ toxicity, reducing Cd2+ uptake and translocation and restoring chloroplast ultrastructure and PSII photochemical efficiency.	Zinc	24-28	CD2 molecule	Homo sapiens	75-78
35051078-11	2022	We conclude that excess Zn2+ application eliminated the adverse effects of Cd2+ toxicity, reducing Cd2+ uptake and translocation and restoring chloroplast ultrastructure and PSII photochemical efficiency.	Zinc	24-28	CD2 molecule	Homo sapiens	99-102
28332702-2	2017	Because protein sequences and functions are highly conserved between A. halleri and Arabidopsis thaliana, Zn tolerance in A. halleri may reflect the constitutively higher MTP1 expression compared with A. thaliana, based on copy number expansion and different cis regulation.	Zinc	106-108	zinc transporter	Arabidopsis thaliana	171-175
28332702-7	2017	A. thaliana mtp1 transgenic lines expressing AtMTP1 controlled by the native A. halleri promoter were more Zn-tolerant than lines carrying mutations on MYB-binding motifs.	Zinc	107-109	zinc transporter	Arabidopsis thaliana	12-16
35051078-12	2022	Thus, excess Zn2+ application can be used as an important method for low Cd2+-accumulating crops, limiting Cd2+ entry into the food chain.	Zinc	13-17	CD2 molecule	Homo sapiens	73-76
28332702-7	2017	A. thaliana mtp1 transgenic lines expressing AtMTP1 controlled by the native A. halleri promoter were more Zn-tolerant than lines carrying mutations on MYB-binding motifs.	Zinc	107-109	zinc transporter	Arabidopsis thaliana	45-51
28332702-9	2017	The different cis-acting elements in the MTP1 promoters of A. halleri, particularly the MYB-binding sites, are probably involved in the evolution of Zn tolerance.	Zinc	149-151	zinc transporter	Arabidopsis thaliana	41-45
35051078-12	2022	Thus, excess Zn2+ application can be used as an important method for low Cd2+-accumulating crops, limiting Cd2+ entry into the food chain.	Zinc	13-17	CD2 molecule	Homo sapiens	107-110
2611263-8	1989	These results indicate that the two Zn2+ ions in TFIIIA are coordinated with the cysteine and histidine residues and are required for maintenance of the proper conformation of TFIIIA.	Zinc	36-40	general transcription factor 3A L homeolog	Xenopus laevis	49-55
2611263-8	1989	These results indicate that the two Zn2+ ions in TFIIIA are coordinated with the cysteine and histidine residues and are required for maintenance of the proper conformation of TFIIIA.	Zinc	36-40	general transcription factor 3A L homeolog	Xenopus laevis	176-182
2628548-0	1989	Quantitative investigation of copper(II) and zinc(II) complexes with S-carboxymethyl-L-cysteine and computer-simulated appraisal of their potential significance in vivo.	Zinc	45-53	serpin family B member 3	Homo sapiens	69-95
28391870-3	2017	On the basis of nanoparticle preparation and immunoprobe construction, PSA in serum was captured, separated by the immunomagnetic probe and then interacted with the quantum dots (QDs) based immunofluorescence probe; Zn2+ inside QDs was replaced by Ag+ within seconds, after which fluorescence signal was amplified by Fluozin-3, the Zn2+ responsive dye.	Zinc	216-220	aminopeptidase puromycin sensitive	Homo sapiens	71-74
28391870-3	2017	On the basis of nanoparticle preparation and immunoprobe construction, PSA in serum was captured, separated by the immunomagnetic probe and then interacted with the quantum dots (QDs) based immunofluorescence probe; Zn2+ inside QDs was replaced by Ag+ within seconds, after which fluorescence signal was amplified by Fluozin-3, the Zn2+ responsive dye.	Zinc	332-336	aminopeptidase puromycin sensitive	Homo sapiens	71-74
2628548-3	1989	Copper(II)- and zinc(II)-SCC complex equilibria have thus been investigated under physiological conditions by means of classical potentiometry combined with computer-assisted calculation techniques.	Zinc	16-24	serpin family B member 3	Homo sapiens	25-28
2502069-0	1989	Inhibition of [3H]platelet activating factor (PAF) binding by Zn2+: a possible explanation for its specific PAF antiaggregating effects in human platelets.	Zinc	62-66	PCNA clamp associated factor	Homo sapiens	46-49
28347465-3	2017	Free Zn2+ deficiency 1) markedly reduced the neuronal survival rate, 2) reduced the peak amplitude of INa, 3) shifted the INa activation curve towards depolarization, 4) modulated the sensitivity of sodium channel voltage-dependent inactivation to a depolarization voltage, and 5) increased the time course of recovery from sodium channel inactivation.	Zinc	5-9	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	102-108
28174029-7	2017	We concluded that a diet with a pharmacological dose of Zn increased the accumulation of Zn and the expression of Bax, cleaved caspase-3, and caspase-8, which might activate the apoptosis and lead to the marked injury of porcine small intestinal epithelium.	Zinc	56-58	apoptosis regulator BAX	Sus scrofa	114-117
2502069-0	1989	Inhibition of [3H]platelet activating factor (PAF) binding by Zn2+: a possible explanation for its specific PAF antiaggregating effects in human platelets.	Zinc	62-66	PCNA clamp associated factor	Homo sapiens	108-111
2502069-2	1989	The concentration of Zn2+ required for 50% inhibition of aggregation (IC50) was inversely proportional to the concentration of PAF present.	Zinc	21-25	PCNA clamp associated factor	Homo sapiens	127-130
2502069-3	1989	The IC50 values (in microM) for Zn2+ were 8.8 +/- 3.9, 27 +/- 5.8, and 34 +/- 1.7 against 2, 5, and 10 nM PAF, respectively (n = 3-6).	Zinc	32-36	PCNA clamp associated factor	Homo sapiens	106-109
2502069-4	1989	Zn2+ exhibited comparable inhibitory effects on [3H]serotonin secretion and the IC50 values (in microM) were 10 +/- 1.2, 18 +/- 3.5, and 35 +/- 0.0 against 2, 5, and 10 nM PAF, respectively (n = 3).	Zinc	0-4	PCNA clamp associated factor	Homo sapiens	172-175
2502069-6	1989	Introduction of Zn2+ within 0-2 min after PAF addition not only blocked further platelet aggregation and [3H]serotonin secretion but also caused reversal of aggregation.	Zinc	16-20	PCNA clamp associated factor	Homo sapiens	42-45
2502069-7	1989	Analysis of [3H]PAF binding to platelets showed that Zn2+ as well as unlabeled PAF prevented the specific binding of [3H]PAF.	Zinc	53-57	PCNA clamp associated factor	Homo sapiens	16-19
27180066-0	2017	Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn2+-Suspension After Single Subcutaneous Injection in Female Rats.	Zinc	85-90	gonadotropin releasing hormone 1	Rattus norvegicus	44-48
2502069-8	1989	The inhibition of [3H]PAF specific binding was proportional to the concentration of Zn2+ and the IC50 value was 18 +/- 2 microM against 1 nM [3H]PAF (n = 3).	Zinc	84-88	PCNA clamp associated factor	Homo sapiens	22-25
28322340-6	2017	Furthermore, Zn2+-induced PARP-1 stimulation, increase in the [Ca2+]c and cell death were inhibited by PF431396, a Ca2+-sensitive PYK2 inhibitor, and U0126, a MEK/ERK inhibitor.	Zinc	13-17	protein tyrosine kinase 2 beta	Homo sapiens	130-134
2502069-8	1989	The inhibition of [3H]PAF specific binding was proportional to the concentration of Zn2+ and the IC50 value was 18 +/- 2 microM against 1 nM [3H]PAF (n = 3).	Zinc	84-88	PCNA clamp associated factor	Homo sapiens	145-148
2502069-10	1989	However, Cd2+ and Cu2+ at high concentrations exhibited a significant inhibition of the aggregation induced by 10 nM PAF with IC50 values being five- and sevenfold higher, respectively, than the IC50 for Zn2+, and with the IC50 values for inhibition of binding of 1 nM [3H]PAF being 5 and 19 times higher, respectively, than the IC50 for Zn2+.	Zinc	204-208	PCNA clamp associated factor	Homo sapiens	117-120
28199213-4	2017	In this review, we will discuss the role of the ZnR/GPR39 in mediating Zn2+-dependent signaling in epithelial tissues and in neurons, where Zn2+ homeostasis plays physiological as well as pathological roles.	Zinc	71-75	G protein-coupled receptor 39	Homo sapiens	52-57
2502069-10	1989	However, Cd2+ and Cu2+ at high concentrations exhibited a significant inhibition of the aggregation induced by 10 nM PAF with IC50 values being five- and sevenfold higher, respectively, than the IC50 for Zn2+, and with the IC50 values for inhibition of binding of 1 nM [3H]PAF being 5 and 19 times higher, respectively, than the IC50 for Zn2+.	Zinc	338-342	PCNA clamp associated factor	Homo sapiens	117-120
28199213-4	2017	In this review, we will discuss the role of the ZnR/GPR39 in mediating Zn2+-dependent signaling in epithelial tissues and in neurons, where Zn2+ homeostasis plays physiological as well as pathological roles.	Zinc	140-144	G protein-coupled receptor 39	Homo sapiens	52-57
28199213-6	2017	Moreover, signaling activated by ZnR/GPR39 plays a key role in mediating effects of Zn2+ in health and disease.	Zinc	84-88	G protein-coupled receptor 39	Homo sapiens	37-42
2502069-11	1989	The specific inhibition of PAF-induced platelet activation and PAF binding to platelets suggested strongly that Zn2+ interacted with the functional receptor site of PAF or at a contiguous site.	Zinc	112-116	PCNA clamp associated factor	Homo sapiens	27-30
2502069-11	1989	The specific inhibition of PAF-induced platelet activation and PAF binding to platelets suggested strongly that Zn2+ interacted with the functional receptor site of PAF or at a contiguous site.	Zinc	112-116	PCNA clamp associated factor	Homo sapiens	63-66
2502069-11	1989	The specific inhibition of PAF-induced platelet activation and PAF binding to platelets suggested strongly that Zn2+ interacted with the functional receptor site of PAF or at a contiguous site.	Zinc	112-116	PCNA clamp associated factor	Homo sapiens	63-66
2502006-5	1989	The percent content of free cholesterol in HDL-E2 was increased in ZD compared with PF and CT. Zn deficiency decreased the plasma concentrations of apo A-I and apo C of HDL-E0 and total apo E associated with HDL-E1 and HDL-E2.	Zinc	95-97	apolipoprotein A1	Rattus norvegicus	148-175
28128494-2	2017	The trimeric anion [(eta4 -Ge9 )Zn{mu2 (eta1 :eta1 Ge9 )}Zn(eta4 -Ge9 )]8- forms as a side product, indicating that oxidation reactions also take place.	Zinc	56-59	secreted phosphoprotein 1	Homo sapiens	40-44
28128494-2	2017	The trimeric anion [(eta4 -Ge9 )Zn{mu2 (eta1 :eta1 Ge9 )}Zn(eta4 -Ge9 )]8- forms as a side product, indicating that oxidation reactions also take place.	Zinc	56-59	secreted phosphoprotein 1	Homo sapiens	46-50
2540174-7	1989	Cd2+ increased [3H]inositol polyphosphates; [3H]inositol trisphosphate increased 4-fold in 15 s. Zn2+ reversibly blocked 45Ca2+ efflux evoked by Cd2+ but not that produced by bradykinin.	Zinc	97-101	CD2 molecule	Homo sapiens	0-3
2540174-7	1989	Cd2+ increased [3H]inositol polyphosphates; [3H]inositol trisphosphate increased 4-fold in 15 s. Zn2+ reversibly blocked 45Ca2+ efflux evoked by Cd2+ but not that produced by bradykinin.	Zinc	97-101	CD2 molecule	Homo sapiens	145-148
28232787-5	2017	The co-administration of Cu2+ and Zn2+ also significantly increased the expression of genes related to the endoplasmic reticulum"s stress response, including CHOP, GADD34, and ATF4.	Zinc	34-38	DNA-damage inducible transcript 3	Mus musculus	158-162
2540174-8	1989	Zn2+ competitively (Ki = approximately 0.4 microM) inhibited net Ca2+ efflux produced by Cd2+.	Zinc	0-4	CD2 molecule	Homo sapiens	89-92
27915020-3	2017	The Zn/Mg-PIII surfaces were found to promote initial adhesion and spreading of rat bone marrow mesenchymal stem cells (rBMSCs) via the upregulation of the gene expression of integrin alpha1 and integrin beta1.	Zinc	4-6	integrin subunit alpha 1	Rattus norvegicus	175-190
2669761-0	1989	Zn(II), Cd(II) and Cu(II) interactions on glutathione reductase and glucose-6-phosphate dehydrogenase.	Zinc	0-2	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	68-101
27890528-2	2017	Here we study the effects of Zn2+ on abnormal aggregation and cytotoxicity of a pathological mutant DeltaK280 of full-length human Tau.	Zinc	29-33	microtubule associated protein tau	Homo sapiens	131-134
2489045-1	1989	We have employed a retroviral vector, ZN(Smu/S gamma 2b)tk1, as a means of introducing immunoglobulin heavy chain (IgH) switch (S) region sequences into B cell lines to directly measure their switch-recombinase activities.	Zinc	38-40	immunoglobulin heavy variable 2-3	Mus musculus	87-113
27890528-4	2017	As evidenced by annexin V-FITC apoptosis detection assay and MTT reduction assay, pathological concentration of Zn2+ remarkably enhances DeltaK280 fibrillization-induced apoptosis and toxicity in SH-SY5Y cells.	Zinc	112-116	annexin A5	Homo sapiens	16-25
27890528-7	2017	The results from isothermal titration calorimetry show that Zn2+ binds to full-length human Tau by interacting with Cys-291 and Cys-322, forming a 1:1 Zn2+-Tau complex.	Zinc	60-64	microtubule associated protein tau	Homo sapiens	92-95
27890528-7	2017	The results from isothermal titration calorimetry show that Zn2+ binds to full-length human Tau by interacting with Cys-291 and Cys-322, forming a 1:1 Zn2+-Tau complex.	Zinc	60-64	microtubule associated protein tau	Homo sapiens	156-159
27890528-7	2017	The results from isothermal titration calorimetry show that Zn2+ binds to full-length human Tau by interacting with Cys-291 and Cys-322, forming a 1:1 Zn2+-Tau complex.	Zinc	151-155	microtubule associated protein tau	Homo sapiens	92-95
27890528-7	2017	The results from isothermal titration calorimetry show that Zn2+ binds to full-length human Tau by interacting with Cys-291 and Cys-322, forming a 1:1 Zn2+-Tau complex.	Zinc	151-155	microtubule associated protein tau	Homo sapiens	156-159
2489045-1	1989	We have employed a retroviral vector, ZN(Smu/S gamma 2b)tk1, as a means of introducing immunoglobulin heavy chain (IgH) switch (S) region sequences into B cell lines to directly measure their switch-recombinase activities.	Zinc	38-40	immunoglobulin heavy variable 2-3	Mus musculus	115-118
28100752-0	2017	Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria.	Zinc	115-119	carbonic anhydrase 1	Mus musculus	30-33
28100752-3	2017	Whereas most studies address contributions of excitotoxic Ca2+ entry, it is apparent that Zn2+ also contributes, reflecting accumulation in neurons either after synaptic release and entry through postsynaptic channels or upon mobilization from intracellular Zn2+-binding proteins such as metallothionein-III (MT-III).	Zinc	90-94	metallothionein 3	Mus musculus	288-307
3293800-2	1988	brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in Xenopus TFIIIA.	Zinc	97-103	general transcription factor 3A L homeolog	Xenopus laevis	151-157
28100752-3	2017	Whereas most studies address contributions of excitotoxic Ca2+ entry, it is apparent that Zn2+ also contributes, reflecting accumulation in neurons either after synaptic release and entry through postsynaptic channels or upon mobilization from intracellular Zn2+-binding proteins such as metallothionein-III (MT-III).	Zinc	90-94	metallothionein 3	Mus musculus	309-315
28100752-4	2017	Using mouse hippocampal slices to study acute oxygen glucose deprivation (OGD)-triggered neurodegeneration, we found evidence for early contributions of excitotoxic Ca2+ and Zn2+ accumulation in both CA1 and CA3, as indicated by the ability of Zn2+ chelators or Ca2+ entry blockers to delay pyramidal neuronal death in both regions.	Zinc	174-178	carbonic anhydrase 1	Mus musculus	200-203
28100752-5	2017	However, using knock-out animals (of MT-III and vesicular Zn2+ transporter, ZnT3) and channel blockers revealed substantial differences in relevant Zn2+ sources, with critical contributions of presynaptic release and its permeation through Ca2+- (and Zn2+)-permeable AMPA channels in CA3 and Zn2+ mobilization from MT-III predominating in CA1.	Zinc	148-152	metallothionein 3	Mus musculus	37-43
28100752-5	2017	However, using knock-out animals (of MT-III and vesicular Zn2+ transporter, ZnT3) and channel blockers revealed substantial differences in relevant Zn2+ sources, with critical contributions of presynaptic release and its permeation through Ca2+- (and Zn2+)-permeable AMPA channels in CA3 and Zn2+ mobilization from MT-III predominating in CA1.	Zinc	148-152	metallothionein 3	Mus musculus	37-43
27802590-0	2017	Reactions of the Zn Proteome with Cd2+ and Other Xenobiotics: Trafficking and Toxicity.	Zinc	17-19	CD2 molecule	Homo sapiens	34-37
3493154-6	1987	Interleukin 2 levels in the supernatants from Zn2+-supplemented cultures were not increased.	Zinc	46-50	interleukin 2	Mus musculus	0-13
27802590-3	2017	The hypothesis is evaluated that Cd2+ damages cells by replacing Zn2+ in key Zn proteins.	Zinc	65-69	CD2 molecule	Homo sapiens	33-36
27802590-3	2017	The hypothesis is evaluated that Cd2+ damages cells by replacing Zn2+ in key Zn proteins.	Zinc	65-67	CD2 molecule	Homo sapiens	33-36
3493154-8	1987	Further studies showed that, in addition to enhancing the production of interleukin 1, Zn2+ enhanced the ability of concanavalin A-activated T cells from aged mice to produce B cell stimulatory factor-1.	Zinc	87-91	interleukin 4	Mus musculus	175-202
27957862-0	2017	Electron Filtering by an Intervening ZnS Thin Film in the Gold Nanoparticle-Loaded CdS Plasmonic Photocatalyst.	Zinc	37-40	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
2434330-1	1986	Native tetrameric alpha 2-macroglobulin molecules (alpha 2M) can be converted into a population of dimers by incubation with various divalent cations such as Zn, Cd, Mg, Cu, Ni, Co.	Zinc	158-160	alpha-2-macroglobulin	Homo sapiens	18-39
27957862-2	2017	Formation of ZnS thin films between the Au NP and CdS film leads to a drastic increase of the photocurrent under visible-light irradiation (lambda &gt; 610 nm) in a 0.1 M NaClO4 aqueous electrolyte solution due to the electron filtering effect.	Zinc	13-16	CDP-diacylglycerol synthase 1	Homo sapiens	50-53
27957862-4	2017	Furthermore, the ZnS overlayer significantly stabilizes the photocurrent of the CdS/FTO electrode in a polysulfide/sulfide electrolyte solution even under the excitation of CdS (lambda &gt; 430 nm).	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
27957862-4	2017	Furthermore, the ZnS overlayer significantly stabilizes the photocurrent of the CdS/FTO electrode in a polysulfide/sulfide electrolyte solution even under the excitation of CdS (lambda &gt; 430 nm).	Zinc	17-20	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	84-87
27957862-4	2017	Furthermore, the ZnS overlayer significantly stabilizes the photocurrent of the CdS/FTO electrode in a polysulfide/sulfide electrolyte solution even under the excitation of CdS (lambda &gt; 430 nm).	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
2434330-1	1986	Native tetrameric alpha 2-macroglobulin molecules (alpha 2M) can be converted into a population of dimers by incubation with various divalent cations such as Zn, Cd, Mg, Cu, Ni, Co.	Zinc	158-160	alpha-2-macroglobulin	Homo sapiens	51-59
2434330-5	1986	The trypsin inhibitory capacity of Zn++-treated alpha 2M has been studied in an attempt to correlate its Zn++-induced conformational changes with its functional modifications.	Zinc	35-39	alpha-2-macroglobulin	Homo sapiens	48-56
2434330-5	1986	The trypsin inhibitory capacity of Zn++-treated alpha 2M has been studied in an attempt to correlate its Zn++-induced conformational changes with its functional modifications.	Zinc	105-109	alpha-2-macroglobulin	Homo sapiens	48-56
27834679-1	2016	The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding.	Zinc	81-85	C-C motif chemokine ligand 3	Homo sapiens	171-175
3768429-7	1986	Zn2+ and Co2+ also inhibited 51Cr release caused by the enterotoxin previously bound to the cell membrane.	Zinc	0-4	cpe	Clostridium perfringens	56-67
27834679-1	2016	The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding.	Zinc	81-85	C-C motif chemokine ligand 4	Homo sapiens	212-216
27693049-1	2016	The antiangiogenic and antitumor activities of the 27-amino acid fragment corresponding to the N-terminal domain of endostatin were shown to be dependent on a Zn-binding loop in the N-terminus.	Zinc	159-161	collagen type XVIII alpha 1 chain	Homo sapiens	116-126
2424021-5	1986	Isolated C8 alpha-gamma exhibited the propensity to polymerize in the presence of Zn2+ and urea, as already demonstrated for C9.	Zinc	82-86	complement C8 alpha chain	Homo sapiens	9-17
27586008-6	2016	The results demonstrated that isoflurane exposure showed no impact on learning and memory function, but induced transient elevation of neuroapoptosis in Zn-adequate APP/PS1 mice.	Zinc	153-155	presenilin 1	Mus musculus	169-172
27586008-8	2016	Appropriate Zn treatment improved learning and memory function, and prevented isoflurane-induced neuroapoptosis in APP/PS1 mice.	Zinc	12-14	presenilin 1	Mus musculus	119-122
27586008-9	2016	Isoflurane exposure may cause potential neurotoxicity, which is tolerated to some extent in Zn-adequate APP/PS1 mice.	Zinc	92-94	presenilin 1	Mus musculus	108-111
2417226-5	1985	P1-mediated hemolysis is Ca2+-dependent and is inhibited by Zn2+ ions.	Zinc	60-64	perforin 1 (pore forming protein)	Mus musculus	0-2
27811086-7	2016	In transgenics, qualitative changes detected for NtZIP1, NtZIP4, NtIRT1-like, and NtVTL are considered crucial for modification of Zn/Cd supply-dependent Zn/Cd root/shoot distribution.	Zinc	131-133	probable zinc transporter 10	Nicotiana tabacum	65-71
27811086-7	2016	In transgenics, qualitative changes detected for NtZIP1, NtZIP4, NtIRT1-like, and NtVTL are considered crucial for modification of Zn/Cd supply-dependent Zn/Cd root/shoot distribution.	Zinc	154-156	probable zinc transporter 10	Nicotiana tabacum	65-71
26956696-5	2016	We found that Zn treatment blockaded tubular EMT and attenuated renal tubulointerstitial fibrosis by downregulation of hypoxia-inducible factor alpha (HIF-1alpha) in the kidneys of diabetic streptozotocin-treated mice.	Zinc	14-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	151-161
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	16-18	glycogen synthase kinase 3 beta	Mus musculus	33-42
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	163-165	glycogen synthase kinase 3 beta	Mus musculus	33-42
3888271-5	1985	Flavones with strong inhibitors of glyoxalase I and gallocyanine (a dye) showed spectral changes on binding to glyoxalase I indicative of binding to a metal-ion site (probably Zn2+ or Mg2+).	Zinc	176-180	glyoxalase I	Homo sapiens	35-47
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	Zinc	163-165	glycogen synthase kinase 3 beta	Mus musculus	218-227
26956696-9	2016	Therefore, we concluded that Zn had an important anti-fibrosis role under HG/hypoxic conditions, and a novel mechanism contributing to Zn protection on renal tubular epithelial cells from HG/hypoxia-induced EMT through activation of PI3K/Akt/GSK-3beta signaling pathway, which subsequently leads to the downregulation of the expression of HIF-1alpha.	Zinc	29-31	glycogen synthase kinase 3 beta	Mus musculus	242-251
26956696-9	2016	Therefore, we concluded that Zn had an important anti-fibrosis role under HG/hypoxic conditions, and a novel mechanism contributing to Zn protection on renal tubular epithelial cells from HG/hypoxia-induced EMT through activation of PI3K/Akt/GSK-3beta signaling pathway, which subsequently leads to the downregulation of the expression of HIF-1alpha.	Zinc	29-31	hypoxia inducible factor 1, alpha subunit	Mus musculus	339-349
27385273-4	2016	MAPK p38 and JNK signaling was able to cross-talk with Gadd45b during Zn(2+) and DA treatment.	Zinc	70-72	mitogen-activated protein kinase 8	Rattus norvegicus	13-16
3888271-5	1985	Flavones with strong inhibitors of glyoxalase I and gallocyanine (a dye) showed spectral changes on binding to glyoxalase I indicative of binding to a metal-ion site (probably Zn2+ or Mg2+).	Zinc	176-180	glyoxalase I	Homo sapiens	111-123
27385273-5	2016	The synergistic effects of Zn(2+) and DA on PC12 cell death can be accounted for by an activation of the Gadd45b-induced cell death pathway and an inhibition of p38/JNK survival pathway.	Zinc	27-29	mitogen-activated protein kinase 8	Rattus norvegicus	165-168
2985563-7	1985	Inhibition by Zn(II) is specifically overcome competitively by Cd(II) or by a concentration of ubiquitin in excess of Zn(II).	Zinc	14-20	ubiquitin	Oryctolagus cuniculus	95-104
27501363-14	2016	Thus, Zn2+ signaling via mZnR/GPR39 is disrupted by Abeta, a critical pathological component of Alzheimer"s disease.	Zinc	6-10	G protein-coupled receptor 39	Homo sapiens	30-35
27634261-2	2016	Total MP2 energies as well as their inner- and inter-shell components are reported for Cu(+), Zn(2+), Ge(4+), Kr(8+), Sr(10+), and Cd(20+).	Zinc	94-96	tryptase pseudogene 1	Homo sapiens	6-9
6089914-3	1984	The cells pretreated with Cd2+ showed slight activity of the release, but no recovery was observed with other divalent cations such as Mg2+, Sr2+, Co2+, Ba2+ and Zn2+.	Zinc	162-166	CD2 molecule	Homo sapiens	26-29
6712919-0	1984	X-ray absorption studies of the Zn2+ site of glyoxalase I.	Zinc	32-36	glyoxalase I	Homo sapiens	45-57
27506361-1	2016	A novel multi-function Metal-Organic Framework composite Ag@Zn-TSA (zinc thiosalicylate, Zn(C7H4O2S), Zn-TSA) was synthesized as highly efficient immobilization matrixes of myoglobin (Mb)/glucose oxidase (GOx) for electrochemical biosensing.	Zinc	60-62	myoglobin	Homo sapiens	173-182
16663096-7	1983	However, the order of preference for the NO(3) (-)-sensitive ATPase (Mn(2+) &gt; Mg(2+) &gt; Co(2+) &gt; Ca(2+) &gt; Zn(2+)) differed from that of the vanadate-sensitive ATPase (Co(2+) &gt; Mg(2+) &gt; Mn(2+) &gt; Zn(2+) &gt; Ca(2+)).	Zinc	117-119	ATPase	Zea mays	61-67
27548057-13	2016	Zn/Cd ratios correlated negatively with alpha1-, alpha2- and beta-globulins.	Zinc	0-2	adrenoceptor alpha 1D	Homo sapiens	40-55
6307260-4	1983	We found that the removal of Z-line and alpha-actinin as well as the release of proteolytic degradation products from isolated myofibrils by CANP occur only in the presence of Ca2+; Sr2+, Ba2+, Mn2+, Mg2+, Co2+ and Zn2+ are all ineffective.	Zinc	215-219	calpain 1	Homo sapiens	141-145
6291507-2	1982	gamma-Butyrobetaine hydroxylase (EC 1.14.11.1) was inhibited by human erythrocyte superoxide dismutase (EC 1.15.1.1), probably due to release of Cu(2+) or Zn(2+), as the inhibition was more pronounced after heat-inactivation of the dismutase and as Cu(2+) was a potent inhibitor.	Zinc	155-157	gamma-butyrobetaine hydroxylase 1	Homo sapiens	0-31
27477125-2	2016	This paper presents a new approach by inserting a ZnS layer between the TiO2 and CdS/ZnS to prepare a TiO2/ZnS/CdS/ZnS sensitized photoelectrode for QDSSC applications.	Zinc	50-53	CDP-diacylglycerol synthase 1	Homo sapiens	81-84
27477125-2	2016	This paper presents a new approach by inserting a ZnS layer between the TiO2 and CdS/ZnS to prepare a TiO2/ZnS/CdS/ZnS sensitized photoelectrode for QDSSC applications.	Zinc	50-53	CDP-diacylglycerol synthase 1	Homo sapiens	111-114
27477125-2	2016	This paper presents a new approach by inserting a ZnS layer between the TiO2 and CdS/ZnS to prepare a TiO2/ZnS/CdS/ZnS sensitized photoelectrode for QDSSC applications.	Zinc	85-88	CDP-diacylglycerol synthase 1	Homo sapiens	111-114
27477125-2	2016	This paper presents a new approach by inserting a ZnS layer between the TiO2 and CdS/ZnS to prepare a TiO2/ZnS/CdS/ZnS sensitized photoelectrode for QDSSC applications.	Zinc	85-88	CDP-diacylglycerol synthase 1	Homo sapiens	111-114
27477125-2	2016	This paper presents a new approach by inserting a ZnS layer between the TiO2 and CdS/ZnS to prepare a TiO2/ZnS/CdS/ZnS sensitized photoelectrode for QDSSC applications.	Zinc	85-88	CDP-diacylglycerol synthase 1	Homo sapiens	111-114
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	9-12	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	9-12	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	9-12	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
6753835-2	1982	Bivalent metal ions, particularly Zn2+ and other members of the first-row transition series, promote irreversible inactivation of yeast hexokinase by Cibacron Blue F3G-A at a site competitive with both ATP and D-glucose.	Zinc	34-38	hexokinase	Saccharomyces cerevisiae S288C	136-146
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
27477125-4	2016	The TiO2/ZnS/CdS/ZnS based QDSSCs exhibited a power conversion efficiency (eta) value of 3.69%, which is significantly higher than the 3.02% and 2.09% observed for solar cells with a TiO2/CdS/ZnS device and without a passivation layer (TiO2/CdS), respectively.	Zinc	17-20	CDP-diacylglycerol synthase 1	Homo sapiens	188-191
6896052-5	1982	Addition of Zn2+ (20 microM) to Co2+-treated liver cell cultures revealed a striking ability of Zn2+ to block completely Co2+-induced heme oxygenase.	Zinc	12-16	complement C2	Homo sapiens	121-124
27477125-5	2016	The elevated performance of the TiO2/ZnS/CdS/ZnS-based QDSSCs was attributed to the pre-assembled ZnS layer enhancing the light harvesting and acting as a blocking layer to shield the TiO2 core from the outer QDs and the electrolyte, thereby retarding the interfacial recombination of electrons from the TiO2 with the electrolyte or with the QDs.	Zinc	37-40	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
27477125-5	2016	The elevated performance of the TiO2/ZnS/CdS/ZnS-based QDSSCs was attributed to the pre-assembled ZnS layer enhancing the light harvesting and acting as a blocking layer to shield the TiO2 core from the outer QDs and the electrolyte, thereby retarding the interfacial recombination of electrons from the TiO2 with the electrolyte or with the QDs.	Zinc	45-48	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
27477125-5	2016	The elevated performance of the TiO2/ZnS/CdS/ZnS-based QDSSCs was attributed to the pre-assembled ZnS layer enhancing the light harvesting and acting as a blocking layer to shield the TiO2 core from the outer QDs and the electrolyte, thereby retarding the interfacial recombination of electrons from the TiO2 with the electrolyte or with the QDs.	Zinc	45-48	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
27477125-6	2016	Electrochemical impedance spectroscopy and open circuit voltage decay measurements showed that the TiO2/ZnS/CdS/ZnS-based QDSSCs inhibit charge recombination remarkably at the photoanode/electrolyte interface and prolong the electron lifetime.	Zinc	104-107	CDP-diacylglycerol synthase 1	Homo sapiens	108-111
27477125-6	2016	Electrochemical impedance spectroscopy and open circuit voltage decay measurements showed that the TiO2/ZnS/CdS/ZnS-based QDSSCs inhibit charge recombination remarkably at the photoanode/electrolyte interface and prolong the electron lifetime.	Zinc	112-115	CDP-diacylglycerol synthase 1	Homo sapiens	108-111
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	secreted phosphoprotein 1	Homo sapiens	227-238
27387130-4	2016	DPSCs cultured on Zn-Ti exhibited significantly up-regulated gene expression levels of osteoblast-related genes of type I collagen (Col I), bone morphogenetic protein 2 (BMP2), ALP, runt-related transcription factor 2 (Runx2), osteopontin (OPN), and vascular endothelial growth factor A (VEGF A), as compared with controls.	Zinc	18-20	secreted phosphoprotein 1	Homo sapiens	240-243
6896052-5	1982	Addition of Zn2+ (20 microM) to Co2+-treated liver cell cultures revealed a striking ability of Zn2+ to block completely Co2+-induced heme oxygenase.	Zinc	96-100	complement C2	Homo sapiens	32-35
6896052-5	1982	Addition of Zn2+ (20 microM) to Co2+-treated liver cell cultures revealed a striking ability of Zn2+ to block completely Co2+-induced heme oxygenase.	Zinc	96-100	complement C2	Homo sapiens	121-124
7037371-5	1982	In addition, we compared the effects of a series of divalent cations (Cu, Zn, Mg, Ca, Fe, Ba, Sr, Mn; 2.5 mM each) on LHRH release and found that copper stimulated release seventeenfold, zinc--sixfold, and the other divalent cations--twofold or less.	Zinc	74-76	gonadotropin releasing hormone 1	Rattus norvegicus	118-122
27044837-5	2016	GPR39, when binding with Zn(2+) has shown promising therapeutic potentials.	Zinc	25-27	G protein-coupled receptor 39	Homo sapiens	0-5
7041245-3	1982	This paper shows that suppression of LIF production caused by phenanthroline could be entirely reversed by Zn2+, Ni2+ and, most effectively, by Co2+.	Zinc	107-111	LIF interleukin 6 family cytokine	Homo sapiens	37-40
7272282-8	1981	The enkephalin-degrading enzyme had a pH optimum of 6.5-7.0 and exhibited maximal activity at 40 degrees C. Enzyme activity was inhibited by metal chelators, and it was found that 1 mol of Zn2+ was associated with 1 mol of enzyme (102000 Mr).	Zinc	189-193	proenkephalin	Rattus norvegicus	4-14
43541-8	1979	Geochemical maps of the North Sea indicate that the contents of Cu, Pb, Zn, Cd and Hg are uniformly low over most of the offshore area although higher concentrations occur in coastal samples.	Zinc	72-74	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	30-33
41579-11	1979	Zn2+, Mn2+, heparin, glutathione and p-chloromercuribenzoate inhibit the ribonuclease, while Na+, K+, EDTA and sermidine have only little or no effect.	Zinc	0-4	ribonuclease	Saccharomyces cerevisiae S288C	73-85
204295-3	1978	The glucosyltransferase and UDPase (uridine diphosphatase) are stimulated by Ca2+ cation, less so by Mg2+ cation, and inhibited by Zn2+.	Zinc	131-135	ectonucleoside triphosphate diphosphohydrolase 4	Homo sapiens	28-34
204295-3	1978	The glucosyltransferase and UDPase (uridine diphosphatase) are stimulated by Ca2+ cation, less so by Mg2+ cation, and inhibited by Zn2+.	Zinc	131-135	ectonucleoside triphosphate diphosphohydrolase 4	Homo sapiens	36-57
179813-0	1976	Metallocytochromes c: characterization of electronic absorption and emission spectra of Sn4+ and Zn2+ cytochromes c. Tin (Sn4+) and zinc (Zn2+) derivatives of horse heart cytochrome c have been prepared and their optical spectra have been characterized.	Zinc	97-101	cytochrome c, somatic	Equus caballus	171-183
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	colony stimulating factor 2	Homo sapiens	167-173
34049221-1	2021	We previously showed that zinc (Zn) deficiency affects the STAT3 signaling pathway in part through redox-regulated mechanisms.	Zinc	32-34	signal transducer and activator of transcription 3	Rattus norvegicus	59-64
34049221-3	2021	This work characterized the temporal profile of cortical STAT3 activation from the mid embryonic stage up to young adulthood in the offspring from dams fed a marginal Zn deficient diet (MZD) throughout gestation and until postnatal day (P) 2.	Zinc	167-169	signal transducer and activator of transcription 3	Rattus norvegicus	57-62
34049221-7	2021	The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation.	Zinc	70-72	signal transducer and activator of transcription 3	Rattus norvegicus	89-94
34049221-7	2021	The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation.	Zinc	70-72	signal transducer and activator of transcription 3	Rattus norvegicus	270-275
34049221-7	2021	The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation.	Zinc	70-72	signal transducer and activator of transcription 3	Rattus norvegicus	270-275
34049221-8	2021	Zn deficiency-associated decreased STAT3 activation adversely impacted astrogliogenesis, leading to a lower astrocyte number in the early postnatal and adult brain cortex.	Zinc	0-2	signal transducer and activator of transcription 3	Rattus norvegicus	35-40
34049221-9	2021	Thus, a decreased availability of Zn during early development can have a major and irreversible adverse effect on astrogliogenesis, in part via multistep alterations in the STAT3 pathway.	Zinc	34-36	signal transducer and activator of transcription 3	Rattus norvegicus	173-178
33662876-7	2021	The addition of CBL altered the acid soluble fraction of both metals to the residual fraction and, thus, reduced the content of Zn (55 and 40%) and Cd (57 and 67%) in the maize roots and shoots, respectively as compared to the control.	Zinc	128-130	Cbl proto-oncogene	Bos taurus	16-19
26629680-3	2016	Indeed, reduction of 1(2+) with Zn afforded 1(.+) as a dark green solid that was characterized by XRD and EPR spectroscopy, and reduction with Mg(Ant) (THF)3 gave 1, which was characterized by (1) H and (31) P NMR spectroscopy.	Zinc	32-34	solute carrier family 25 member 6	Homo sapiens	146-149
26799971-0	2016	Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	53-55	carnosine dipeptidase 1	Homo sapiens	72-85
26799971-0	2016	Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	53-55	carnosine dipeptidase 1	Homo sapiens	87-91
26799971-0	2016	Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	119-121	carnosine dipeptidase 1	Homo sapiens	87-91
26799971-0	2016	Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	119-121	carnosine dipeptidase 1	Homo sapiens	134-138
26799971-4	2016	METHODS AND RESULTS: Epitope mapping using myc-tagged CN-1 fragments and overlapping peptides revealed that the RYSK173 epitope directly contributes to the formation of the dinuclear Zn center in the catalytic domain of homodimeric CN-1.	Zinc	183-185	carnosine dipeptidase 1	Homo sapiens	54-58
26799971-4	2016	METHODS AND RESULTS: Epitope mapping using myc-tagged CN-1 fragments and overlapping peptides revealed that the RYSK173 epitope directly contributes to the formation of the dinuclear Zn center in the catalytic domain of homodimeric CN-1.	Zinc	183-185	carnosine dipeptidase 1	Homo sapiens	232-236
26658105-0	2016	Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.	Zinc	22-24	dual specificity phosphatase 2	Mus musculus	75-80
26658105-3	2016	B-PAC-1, a procaspase activating compound, induces apoptosis by sequestering Zn bound to procaspase-3, but the amino acids holding Zn in Caspase-3 is not known.	Zinc	77-79	dual specificity phosphatase 2	Mus musculus	2-7
26658105-3	2016	B-PAC-1, a procaspase activating compound, induces apoptosis by sequestering Zn bound to procaspase-3, but the amino acids holding Zn in Caspase-3 is not known.	Zinc	131-133	dual specificity phosphatase 2	Mus musculus	2-7
26658105-6	2016	Mutants carrying E272A abrogated Zn-reversal of apoptosis induced by B-PAC-1 via higher XIAP and smac expressions but not in H108A or C148S mutants.	Zinc	33-35	dual specificity phosphatase 2	Mus musculus	71-76
26658105-11	2016	This study underscores the first genetic evidence that B-PAC-1 driven apoptosis is mediated via Zn chelation.	Zinc	96-98	dual specificity phosphatase 2	Mus musculus	57-62
26538236-2	2016	The zinc (Zn) transporter ZnT4 (SLC30A4) transports Zn into the trans-Golgi apparatus for lactose synthesis, and across the apical cell membrane for efflux from MECs into milk.	Zinc	10-12	solute carrier family 30 (zinc transporter), member 4	Mus musculus	26-30
26538236-2	2016	The zinc (Zn) transporter ZnT4 (SLC30A4) transports Zn into the trans-Golgi apparatus for lactose synthesis, and across the apical cell membrane for efflux from MECs into milk.	Zinc	10-12	solute carrier family 30 (zinc transporter), member 4	Mus musculus	32-39
26538236-3	2016	This is consistent with observations in "lethal milk" (lm/lm) mice, which have a truncation mutation in SLC30A4, and present with not only low milk Zn concentration, but also smaller mammary glands, decreased milk volume, and lactation failure by lactation day 2.	Zinc	148-150	solute carrier family 30 (zinc transporter), member 4	Mus musculus	104-111
34040623-6	2021	Such studies on the nutrient interaction pathways suggest that an MYB-like transcription factor, phosphate starvation response 1 (PHR1), acts as a master regulator of N, P, S, Fe, and Zn homeostasis.	Zinc	184-186	phosphate starvation response 1	Arabidopsis thaliana	97-128
34040623-6	2021	Such studies on the nutrient interaction pathways suggest that an MYB-like transcription factor, phosphate starvation response 1 (PHR1), acts as a master regulator of N, P, S, Fe, and Zn homeostasis.	Zinc	184-186	phosphate starvation response 1	Arabidopsis thaliana	130-134
33990039-8	2021	The variation partitioning analysis showed heavy metals (mainly Cr and Zn) were the major drivers that affect the profile of ARGs (ARG transcripts).	Zinc	71-73	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	125-128
33412350-0	2021	Fabrication, characterization and photoelectrochemical properties of CdS/CdSe nanofilm co-sensitized ZnO nanorod arrays on Zn foil substrate.	Zinc	101-103	CDP-diacylglycerol synthase 1	Homo sapiens	69-72
33412350-2	2021	In order to overcome these drawbacks, ZnO/CdS/CdSe heterostructures are prepared on Zn foil substrate using facile three-step methods containing hydrothermal growth, successive ionic layer adsorption reaction (SILAR) and modified chemical bath deposition (CBD).	Zinc	38-40	CDP-diacylglycerol synthase 1	Homo sapiens	42-45
33635301-5	2021	With the ESIPT property, HL1 and HL2 could also detect Zn2+ ions via the "turn on" mode in EtOH/HEPES media.	Zinc	55-59	intelectin 1	Homo sapiens	25-28
33898275-12	2021	Chitosan, carboxymethyl cellulose, alginate and lignin based nanocomposites have demonstrated better adsorption activities due to great physical and chemical properties for the chelation of heavy metals such as Cd2+, Pb2+ and Zn2+ from water and also higher regeneration with various eluents after several desorption-adsorption cycles.	Zinc	226-230	CD2 molecule	Homo sapiens	211-214
33576627-5	2021	TO-317 exhibits 158-fold selectivity for HDAC6 over other HDAC isozymes by binding the catalytic Zn2+ and, uniquely, making a never seen before direct hydrogen bond with the Zn2+ coordinating residue, His614.	Zinc	97-101	histone deacetylase 6	Danio rerio	41-46
33576627-5	2021	TO-317 exhibits 158-fold selectivity for HDAC6 over other HDAC isozymes by binding the catalytic Zn2+ and, uniquely, making a never seen before direct hydrogen bond with the Zn2+ coordinating residue, His614.	Zinc	174-178	histone deacetylase 6	Danio rerio	41-46
32697740-4	2021	Its binding to the GLO-I active site seemed to be mainly driven by ionic interaction via its ionized hydroxyl groups with the central Zn ion and Lys156, along with other numerous hydrogen bonding and hydrophobic interactions.	Zinc	134-136	glyoxalase I	Homo sapiens	19-24
26268338-4	2016	The coordination ability of flavonoids, and therefore their ability to inhibit GLOI, is determined by the Zn(2+) coordination geometry, the rigid skeleton of flavonoids and the geometry of the hydrophobic cavity of the GLOI active site.	Zinc	106-112	glyoxalase I	Homo sapiens	79-83
33673282-5	2021	The reduction of the BDNF serum level after co-administration of DPCPX and istradefylline with Mg2+ and Zn2+ was noted.	Zinc	104-108	brain derived neurotrophic factor	Mus musculus	21-25
33538977-6	2021	When MP100 (average size: 129 mum) content in soil increased to 10%, the adsorption capacities of soil with Pb2+ and Zn2+ were 3.73 and 4.56 mg/g, respectively, which were significantly (p < 0.05) lower than that of pure soil.	Zinc	117-121	aminopeptidase puromycin sensitive	Homo sapiens	5-10
33360236-8	2021	The expression of ZmPIP1;1, ZmPIP1;2, and ZmPIP2;2 was significantly higher with moderate Zn treatment than that of low-level Zn treatment.	Zinc	90-92	aquaporin PIP1-1	Zea mays	18-26
27882894-11	2016	GGH was able to form robust metal adducts not only with Cu(II) and the related divalent Zn(II) and Ni(II) ions, but also with monovalent ions, including Cu(I) and Ag(I).	Zinc	88-90	gamma-glutamyl hydrolase	Homo sapiens	0-3
33360236-8	2021	The expression of ZmPIP1;1, ZmPIP1;2, and ZmPIP2;2 was significantly higher with moderate Zn treatment than that of low-level Zn treatment.	Zinc	126-128	aquaporin PIP1-1	Zea mays	18-26
26524639-5	2016	RESULTS: It found that GPR39 mRNA and protein were expressed in porcine intramuscular preadipocytes and its expression was significantly up-regulated after treatment with Zn(2+) whose function is found to be mediated by GPR39.	Zinc	171-173	G protein-coupled receptor 39	Homo sapiens	23-28
33297055-5	2021	An extended dual-mode isotherm model, which takes into account both sorption and chemical precipitation, provided the best fits to the sorption isotherms, giving a maximum Langmuir sorption capacity of 141.1 mg g-1 for Zn2+ and 150.2 mg g-1 for Cd2+ by CMC-CAP.	Zinc	219-223	CD2 molecule	Homo sapiens	245-248
26524639-5	2016	RESULTS: It found that GPR39 mRNA and protein were expressed in porcine intramuscular preadipocytes and its expression was significantly up-regulated after treatment with Zn(2+) whose function is found to be mediated by GPR39.	Zinc	171-173	G protein-coupled receptor 39	Homo sapiens	220-225
33126054-2	2021	Several redox-relevant micronutrients are known to contribute to an adequate immune response, including the essential trace elements zinc (Zn) and selenium (Se).	Zinc	139-141	squalene epoxidase	Homo sapiens	0-2
26524639-9	2016	CONCLUSION: It indicated that GPR39 was a transducer of Zn(2+), and enhanced proliferation and differentiation of porcine intramuscular preadipocytes through activation of the PI3K/Akt signaling pathway.	Zinc	56-58	G protein-coupled receptor 39	Homo sapiens	30-35
33504706-6	2021	Mo(VI)-MIIP exhibited an excellent adsorption selectivity to Mo(VI) in binary mixtures of Mo(VI)/Cr(VI), Mo(VI)/Cu(II), Mo(VI)/H2PO44-, Mo(VI)/Zn(II), and Mo(VI)/I-, with relative selectivity coefficients toward MNIP of 13.71, 30.27, 20.01, 23.53, and 15.89, respectively.	Zinc	143-145	migration and invasion inhibitory protein	Homo sapiens	7-11
26766877-7	2016	The detection limits are 0.07, 0.10, 0.07, 0.08, 0.06 and 0.10 ng mL-1 for Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Pb(II), respectively.	Zinc	108-110	L1 cell adhesion molecule	Mus musculus	66-70
26511260-2	2015	Source identification analysis indicated that PC1, including Al, Fe, Mn, Cr, Ni, As, Cu, and Zn, can be defined as a sewage component; PC2, including Pb and Sb, can be considered as an atmospheric deposition component; and PC3, containing Cd and Hg, can be considered as an agricultural nonpoint component.	Zinc	93-95	proprotein convertase subtilisin/kexin type 1	Homo sapiens	46-49
26253511-5	2015	Molecular docking results indicated that the main active binding site for GBA has been located in a hydrophobic cavity in the vicinity of Zn atom.	Zinc	138-140	glucosylceramidase beta	Homo sapiens	74-77
26462907-11	2015	Four metals (Co, Mn, Ni, Zn) demonstrated significant positive correlations (p &lt; 0.05) with 11beta-HSD2 expression.	Zinc	25-27	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	95-106
26462907-12	2015	Sex specific differences were found; Co, Cu, Fe, Zn, and Ni were positively correlated with 11beta-HSD2 expression in males only, no significant correlations were found in the female only sample.	Zinc	49-51	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	92-103
26284970-3	2015	Overexpression of alphaSyn increased intracellular Mn levels, whereas levels of Ca, Zn, K, P, and S were significantly decreased.	Zinc	84-86	synuclein alpha	Homo sapiens	18-26
26411703-1	2015	Oxindolimine-copper(II) and zinc(II) complexes that previously have shown to induce apoptosis, with DNA and mitochondria as main targets, exhibit here significant inhibition of kinase CDK1/cyclin B protein.	Zinc	28-36	cyclin dependent kinase 1	Homo sapiens	184-188
28717503-0	2015	Self-assembly of a mesoporous ZnS/mediating interface/CdS heterostructure with enhanced visible-light hydrogen-production activity and excellent stability.	Zinc	30-33	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
28717503-1	2015	We designed and successfully fabricated a ZnS/CdS 3D mesoporous heterostructure with a mediating Zn1-x Cd x S interface that serves as a charge carrier transport channel for the first time.	Zinc	42-45	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
32818499-5	2020	Mechanically, post-transcriptional regulated protein quantities compromising phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway was demonstrated true causative forces inside the cell for Zn against As poisoning.	Zinc	241-243	protein tyrosine kinase 2 beta	Homo sapiens	114-130
33294736-6	2021	RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/beta-catenin, PI3K/Akt, and MAPK/Erk signaling pathways.	Zinc	36-38	catenin beta 1	Rattus norvegicus	95-107
33074685-6	2020	DFT calculations rationalize these different outcomes in terms of the energies of the square-pyramidal Ru(ZnPhos)L2 intermediates in which Zn sits in a basal site: for L = CO, this is readily accessed and allows H2 to add across the Ru-Zn bond, but for L = IMe4, this species is kinetically inaccessible and reaction can only occur at the Ru center.	Zinc	139-141	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	257-261
32570030-3	2020	The improved functions of HGnFs over the ZnO@ZnS nanorod-array were attributed to the material"s optimized zinc release, which was decreased from an order of 3.5 mg L-1 to about 0.3 mg L-1 (within the first week).	Zinc	45-48	L1 cell adhesion molecule	Mus musculus	165-168
32570030-3	2020	The improved functions of HGnFs over the ZnO@ZnS nanorod-array were attributed to the material"s optimized zinc release, which was decreased from an order of 3.5 mg L-1 to about 0.3 mg L-1 (within the first week).	Zinc	45-48	L1 cell adhesion molecule	Mus musculus	185-188
32784022-4	2020	Here, we report on the activity of Bst exo- in the presence of Mg2+, Mn2+, Ca2+, Cd2+, Co2+, Cu2+, Ni2+ and Zn2+ in the model molecular systems which included amplification of circular and linear DNA templates; conditions providing effective and highly specific isothermal amplification were determined.	Zinc	108-112	CD2 molecule	Homo sapiens	81-84
26103462-0	2015	Structure and aggregation properties of a Schiff-base zinc(II) complex derived from cis-1,2-diaminocyclohexane.	Zinc	54-62	suppressor of cytokine signaling 1	Homo sapiens	84-89
27114935-7	2016	After the patients received chemoradiotherapy for 4 weeks, SMD-2 treatment was found to be associated with a significant decrease in urinary Cu levels, whereas urinary Zn and Se levels increased significantly.	Zinc	168-170	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	59-64
27114935-11	2016	The SMD-2 treatments significantly increased Zn and Se levels in the urine of head and neck cancer patients.	Zinc	45-47	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	4-9
25872526-4	2015	The present study identified that 10 microM of Zn supplementation prevented EMT changes, such as the loss of E-cadherin and the increase in alpha-smooth muscle actin and vimentin expression.	Zinc	47-49	cadherin 1	Rattus norvegicus	109-119
25872526-4	2015	The present study identified that 10 microM of Zn supplementation prevented EMT changes, such as the loss of E-cadherin and the increase in alpha-smooth muscle actin and vimentin expression.	Zinc	47-49	actin gamma 2, smooth muscle	Rattus norvegicus	140-165
25817891-7	2015	Allosteric suppression of some of the pore-forming Cavalpha1-subunits (Cav2.3, Cav3.2) by Zn(2+) and Cu(2+) may play a major role for the regulation of excitability by endogenous transition metal ions.	Zinc	90-92	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	71-77
25724285-5	2015	While Zn and/or PQ elevated the total free radical generation, lipid peroxidation (LPO) and catalytic activity of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase alpha 4-4 (GSTA4-4), a pronounced decrease in reduced glutathione (GSH) and glutathione reductase (GR) activity was also observed.	Zinc	6-8	myeloperoxidase	Rattus norvegicus	114-129
25724285-5	2015	While Zn and/or PQ elevated the total free radical generation, lipid peroxidation (LPO) and catalytic activity of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase alpha 4-4 (GSTA4-4), a pronounced decrease in reduced glutathione (GSH) and glutathione reductase (GR) activity was also observed.	Zinc	6-8	myeloperoxidase	Rattus norvegicus	131-134
25879496-2	2015	HDAC8 is a Zn(II) -based, single-peptide mammalian histone deacetylase that is localized mainly in the cytoskeleton of smooth muscle cells, thus regulating muscle contractility.	Zinc	11-17	histone deacetylase 8	Homo sapiens	0-5
25511253-6	2015	The reactivity of the Zn-loaded forms of MT1 and MT4 is intermediate between those of MT3 and MT2.	Zinc	22-24	metallothionein 1I, pseudogene	Homo sapiens	41-44
25511253-6	2015	The reactivity of the Zn-loaded forms of MT1 and MT4 is intermediate between those of MT3 and MT2.	Zinc	22-24	metallothionein 2A	Homo sapiens	94-97
24939099-1	2015	The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group.	Zinc	156-158	transcription factor like 5	Homo sapiens	117-120
25366467-10	2015	The enzymatic activities, particularly ascorbate peroxidase, and the content of reduced glutathione could be considered good biomarkers of serious stress by Zn in soils.	Zinc	157-159	peroxidase-like	Triticum aestivum	49-59
25523480-7	2015	SIN-1 prevented the inactivation of glutathione reductase (GR) and the increase in the ratio of oxidized glutathione/total glutathione (GSSG/total GSH) induced by Zn(2+).	Zinc	163-165	glutathione-disulfide reductase	Rattus norvegicus	59-61
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	115-118
25201908-7	2015	The CPCs with ZnBG showed increased ALP activity, enhanced formation of mineralized nodules, and upregulated mRNA expression of DMP-1, DSPP, Runx2, and osterix in a time- and dose-dependent manner, relative to CPCs without Zn.	Zinc	14-16	dentin matrix acidic phosphoprotein 1	Homo sapiens	128-133
25620235-4	2015	The Zn transporter ZnT2 imports Zn into vesicles and mitochondria and ZnT2-overexpression activates cell death in mammary epithelial cells (MECs).	Zinc	4-6	solute carrier family 30 (zinc transporter), member 2	Mus musculus	19-23
25620235-4	2015	The Zn transporter ZnT2 imports Zn into vesicles and mitochondria and ZnT2-overexpression activates cell death in mammary epithelial cells (MECs).	Zinc	4-6	solute carrier family 30 (zinc transporter), member 2	Mus musculus	70-74
32559275-0	2020	Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study.	Zinc	0-4	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	24-30
25590806-6	2015	Based on mechanistic studies, Se(4+), which is similar to As(3+), might bind directly to Zn(2+)-binding sites of the PML RING domain, thus controlling the fate of PML-RARalpha oncoprotein.	Zinc	89-95	PML nuclear body scaffold	Homo sapiens	117-120
25590806-6	2015	Based on mechanistic studies, Se(4+), which is similar to As(3+), might bind directly to Zn(2+)-binding sites of the PML RING domain, thus controlling the fate of PML-RARalpha oncoprotein.	Zinc	89-95	PML nuclear body scaffold	Homo sapiens	163-166
25446533-10	2014	The AR stimulated by Zn(2+) is mediated by GPR39 receptor, PKA, Src and the EGFR, as well as the EGFR down-stream effectors PI3K, phospholipase C (PLC) and protein kinase C (PKC).	Zinc	21-23	G protein-coupled receptor 39	Homo sapiens	43-48
32559275-2	2020	Cav2.3 voltage-gated Ca2+ channels are among the most sensitive targets of Zn2+ and are therefore likely to be involved in the neuromodulatory actions of endogenous Zn2+.	Zinc	75-79	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	0-6
25270168-8	2014	Bone resorption, TRAP(+) cells and expression of Tnfa, Il10 and Runx2 were significantly diminished in 5-LO(-/-), ZN- and MT-treated mice.	Zinc	114-116	runt related transcription factor 2	Mus musculus	64-69
32559275-2	2020	Cav2.3 voltage-gated Ca2+ channels are among the most sensitive targets of Zn2+ and are therefore likely to be involved in the neuromodulatory actions of endogenous Zn2+.	Zinc	165-169	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	0-6
32559275-4	2020	Here, we use a combination of electrophysiological recordings, modification of histidine residues, and computational modeling to analyze Zn2+-induced changes in Cav2.3 channel function.	Zinc	137-141	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	161-167
32559275-5	2020	Our most important findings are that multiple high- and low-affinity mechanisms contribute to the net Zn2+ action, that Zn2+ can either inhibit or stimulate Ca2+ influx through Cav2.3 channels depending on resting membrane potential, and that Zn2+ effects may persist for some time even after cessation of the Zn2+ signal.	Zinc	120-124	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	177-183
32559275-5	2020	Our most important findings are that multiple high- and low-affinity mechanisms contribute to the net Zn2+ action, that Zn2+ can either inhibit or stimulate Ca2+ influx through Cav2.3 channels depending on resting membrane potential, and that Zn2+ effects may persist for some time even after cessation of the Zn2+ signal.	Zinc	120-124	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	177-183
25310175-16	2014	A second Zn(2+) complex containing an acridine pendent, Zn(ACR), binds tightly to pentanucleotides with both tandem and spaced thymines.	Zinc	9-15	acrosin	Homo sapiens	59-62
25310175-16	2014	A second Zn(2+) complex containing an acridine pendent, Zn(ACR), binds tightly to pentanucleotides with both tandem and spaced thymines.	Zinc	9-12	acrosin	Homo sapiens	59-62
32559275-5	2020	Our most important findings are that multiple high- and low-affinity mechanisms contribute to the net Zn2+ action, that Zn2+ can either inhibit or stimulate Ca2+ influx through Cav2.3 channels depending on resting membrane potential, and that Zn2+ effects may persist for some time even after cessation of the Zn2+ signal.	Zinc	120-124	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	177-183
32559275-6	2020	Computer simulations show that (1) most salient features of Cav2.3 channel gating in the absence of trace metals can be reproduced by an obligatory model in which activation of two voltage sensors is necessary to open the pore; and (2) most, but not all, of the effects of Zn2+ can be accounted for by assuming that Zn2+ binding to a first site is associated with an electrostatic modification and mechanical slowing of one of the voltage sensors, whereas Zn2+ binding to a second, lower-affinity site blocks the channel and modifies the opening and closing transitions.	Zinc	273-277	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	60-66
25051343-5	2014	We found that the exogenous Zn(2+) in the exposure range (31.25-125.0 mumol/L) results in the overgeneration of ROS, cell cycle arrest at G2/M phases, elevation of cytosolic [Ca(2+)], inactivation of Ca(2+)-ATPase and reduction of both PMCA1 and PMCA2 in 661 W cells, and thus induces cell death.	Zinc	28-30	ATPase, Ca++ transporting, plasma membrane 2	Mus musculus	246-251
32559275-6	2020	Computer simulations show that (1) most salient features of Cav2.3 channel gating in the absence of trace metals can be reproduced by an obligatory model in which activation of two voltage sensors is necessary to open the pore; and (2) most, but not all, of the effects of Zn2+ can be accounted for by assuming that Zn2+ binding to a first site is associated with an electrostatic modification and mechanical slowing of one of the voltage sensors, whereas Zn2+ binding to a second, lower-affinity site blocks the channel and modifies the opening and closing transitions.	Zinc	316-320	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	60-66
32559275-6	2020	Computer simulations show that (1) most salient features of Cav2.3 channel gating in the absence of trace metals can be reproduced by an obligatory model in which activation of two voltage sensors is necessary to open the pore; and (2) most, but not all, of the effects of Zn2+ can be accounted for by assuming that Zn2+ binding to a first site is associated with an electrostatic modification and mechanical slowing of one of the voltage sensors, whereas Zn2+ binding to a second, lower-affinity site blocks the channel and modifies the opening and closing transitions.	Zinc	316-320	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	60-66
32559275-7	2020	While still far from complete, our model provides a first quantitative framework for understanding Zn2+ effects on Cav2.3 channel function and a step toward the application of computational approaches for predicting the complex actions of Zn2+ on neuronal excitability.	Zinc	99-103	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	115-121
32867354-0	2020	Influence of Welding Speed on Characteristics of Non-Axisymmetric Laser-Tungsten Inert Gas Hybrid Welded Mg/Al Lap Joints with Zn Filler.	Zinc	127-129	LAP	Homo sapiens	111-114
25008783-2	2014	STXM and XANES results confirm that the as-prepared product is ZnO/CdS core/shell nanowires (NWs), and further indicate that ZnS was formed on the surface of ZnO NWs as the interface between ZnO and CdS.	Zinc	125-128	CDP-diacylglycerol synthase 1	Homo sapiens	67-70
25008783-2	2014	STXM and XANES results confirm that the as-prepared product is ZnO/CdS core/shell nanowires (NWs), and further indicate that ZnS was formed on the surface of ZnO NWs as the interface between ZnO and CdS.	Zinc	125-128	CDP-diacylglycerol synthase 1	Homo sapiens	199-202
32825449-12	2020	Zn + IMI also induced an increase in the ZnT4 protein level in the PFC compared to the control group and normalized the Zn-induced decrease in the ZnT1 protein level in the hippocampus (Hp).	Zinc	0-2	solute carrier family 30 (zinc transporter), member 4	Mus musculus	41-45
32875247-0	2020	Ethanol Gas Sensing by a Zn-Terminated ZnO(0001) Bulk Single-Crystalline Substrate.	Zinc	25-27	gastrin	Homo sapiens	8-11
25026551-1	2014	In a previous study, we reported that some tetradentate zinc(II) chelators inhibit p53 through the denaturation of its zinc-requiring structure but a chelator, Bispicen, a potent inhibitor of in vitro apoptosis, failed to show any efficient radioprotective effect against irradiated mice because the toxicity of the chelator to mice.	Zinc	56-64	transformation related protein 53, pseudogene	Mus musculus	83-86
25026551-2	2014	The unsuitability of using tetradentate chelators as radioprotectors prompted us to undertake a more extensive search for p53-inhibiting agents that are weaker zinc(II) chelators and therefore less toxic.	Zinc	160-168	transformation related protein 53, pseudogene	Mus musculus	122-125
25140151-4	2014	AMPARs lacking GluA2 or containing the unedited subunit are permeable to Ca(2+) and Zn(2+).	Zinc	84-86	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	0-6
32517868-7	2020	Knockdown of zip10 reduced free Zn2+ in HGC, ceased their normal developmental apoptosis, and resulted in displacement and later disappearance of hatching glands and hatching enzymes he1a and catL1b, and inability to hatch.	Zinc	32-36	solute carrier family 39 member 10	Danio rerio	13-18
31773485-9	2020	ZnG supplementation at 90 mg Zn/kg affected the duodenal mucus by significantly increasing ZnT1, 6, 7, ZIP13, and MT-4 mRNA level (P < 0.05).	Zinc	0-2	solute carrier family 39 member 13	Gallus gallus	103-108
24853956-6	2014	Apo 1a and 1b extract more than 50% of the Zn(2+) from an equimolar amount of [Zn(TPEN)](2+) (TPEN = N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine) or [Zn(EDTA)](2-), whereas TPEN and EDTA cannot effectively remove Zn(2+) from [Zn(1a)] and [Zn(1b)].	Zinc	43-45	Fas cell surface death receptor	Homo sapiens	0-5
31951514-8	2020	Together the results show that exposure of ESBL-producing E. coli to Zn and Cu reduce horizontal transfer of the blaCMY-2 resistance plasmid by reducing expression of genes involved in conjugation in the plasmid donor strain.	Zinc	69-71	AmpC	Escherichia coli	113-121
24853956-6	2014	Apo 1a and 1b extract more than 50% of the Zn(2+) from an equimolar amount of [Zn(TPEN)](2+) (TPEN = N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine) or [Zn(EDTA)](2-), whereas TPEN and EDTA cannot effectively remove Zn(2+) from [Zn(1a)] and [Zn(1b)].	Zinc	79-81	Fas cell surface death receptor	Homo sapiens	0-5
24853956-6	2014	Apo 1a and 1b extract more than 50% of the Zn(2+) from an equimolar amount of [Zn(TPEN)](2+) (TPEN = N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine) or [Zn(EDTA)](2-), whereas TPEN and EDTA cannot effectively remove Zn(2+) from [Zn(1a)] and [Zn(1b)].	Zinc	79-81	Fas cell surface death receptor	Homo sapiens	0-5
32199367-3	2020	O-F increased (29%) chlorophyll levels and counteracted Zn"s effect.	Zinc	56-58	Spi-1 proto-oncogene	Homo sapiens	0-3
24853956-6	2014	Apo 1a and 1b extract more than 50% of the Zn(2+) from an equimolar amount of [Zn(TPEN)](2+) (TPEN = N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine) or [Zn(EDTA)](2-), whereas TPEN and EDTA cannot effectively remove Zn(2+) from [Zn(1a)] and [Zn(1b)].	Zinc	79-81	Fas cell surface death receptor	Homo sapiens	0-5
24264723-3	2014	Here, we show that GPR39 is mediating Zn(2+) -dependent Ca(2+) responses and is regulating activity of MAP and PI3 pathways in prostate cancer cells, PC3, and ductal salivary gland cells, HSY.	Zinc	38-44	G protein-coupled receptor 39	Homo sapiens	19-24
32199367-10	2020	Zn recovery efficiency was in the order O-F > nano-ZnO > bulk-ZnO, regardless of the water status.	Zinc	0-2	Spi-1 proto-oncogene	Homo sapiens	40-43
32545833-8	2020	Furthermore, Zn2+ is a direct concentration-dependent inhibitor of NAT8L activity, while Zn2+-triggered oxidative stress is unlikely to be significant in such suppression.	Zinc	13-17	N-acetyltransferase 8-like	Rattus norvegicus	67-72
32677757-1	2020	Methionine (Met) cationized with Zn2+ , forming Zn (Met-H)+ (ACN) where ACN = acetonitrile, Zn (Met-H)+ , and ZnCl+ (Met), as well as Cd2+ , forming CdCl+ (Met), were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from the FELIX free electron laser.	Zinc	48-50	CD2 molecule	Homo sapiens	134-137
25079991-6	2014	Strong inverse proportionality was calculated between the contents of Pb, Zn, Ni, Cr and Mn and CaO, so these elements showed association to materials other than Ca-bearing compounds (e.g., to aluminosilicates, organic matter, etc.).	Zinc	74-76	mummy	Drosophila melanogaster	96-99
24759986-7	2014	Inhibition of recombinant PTEN by Zn(2+)in vitro yielded an IC50 of 0.59 nM.	Zinc	34-36	phosphatase and tensin homolog	Homo sapiens	26-30
24759986-9	2014	Oxidation with H2O2 and supplementation with Zn(2+) led to similar changes in the CD spectrum of PTEN.	Zinc	45-47	phosphatase and tensin homolog	Homo sapiens	97-101
24970226-7	2014	XAS on HPRG isolated from the AMPD complex showed that zinc is bound to the protein in a dinuclear cluster where each Zn2+ ion is coordinated by three histidine and one heavier ligand, likely sulfur from cysteine.	Zinc	118-122	adenosine monophosphate deaminase 1	Homo sapiens	30-34
24697266-0	2014	Thermodynamic and structural characterization of the specific binding of Zn(II) to human protein DJ-1.	Zinc	73-75	Parkinsonism associated deglycase	Homo sapiens	97-101
24697266-4	2014	Herein, we report that Zn(II) binds to DJ-1 with great selectivity among the other metals examined: Mn(II), Fe(II), Co(II), Ni(II), and Cu(II).	Zinc	23-29	Parkinsonism associated deglycase	Homo sapiens	39-43
24697266-6	2014	These results suggest that DJ-1 may be regulated and/or stabilized by Zn(II).	Zinc	70-72	Parkinsonism associated deglycase	Homo sapiens	27-31
32040263-1	2020	Metal-CO 2 batteries, an attractive technology for both energy storage and CO 2 utilization, are typically classified into organic Li(Na)-CO 2 batteries with a high energy density/output voltage and aqueous Zn-CO 2 batteries with flexible chemical production.	Zinc	207-209	complement C2	Homo sapiens	6-10
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	solute carrier family 39 member 4	Sus scrofa	141-148
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	solute carrier family 39 member 4	Sus scrofa	150-154
31918077-4	2020	The ITC analyses of exchange reactions demonstrated that Zn-ShMT exhibited up to 6, 6, and 7 binding sites for Cd2+, Pb2+ and Cu2+.	Zinc	57-59	serine hydroxymethyltransferase 1	Homo sapiens	60-64
31918077-4	2020	The ITC analyses of exchange reactions demonstrated that Zn-ShMT exhibited up to 6, 6, and 7 binding sites for Cd2+, Pb2+ and Cu2+.	Zinc	57-59	CD2 molecule	Homo sapiens	111-114
31918077-5	2020	By the analyses of the UV and CD spectra in the substitution experiments showed that the geometric structural stability of metal-ShMT could be influenced when excess of over 6, 6, or 7 equivalents of Cd2+, Pb2+, or Cu2+ were added into Zn-ShMT.	Zinc	236-238	serine hydroxymethyltransferase 1	Homo sapiens	129-133
24565835-8	2014	The present results demonstrated that Zn supplementation protected against CP-induced testicular damages by modulating metallothionein (MT), tesmin and Nrf2 associated pathways.	Zinc	38-40	testis expressed metallothionein like protein	Rattus norvegicus	141-147
31918077-5	2020	By the analyses of the UV and CD spectra in the substitution experiments showed that the geometric structural stability of metal-ShMT could be influenced when excess of over 6, 6, or 7 equivalents of Cd2+, Pb2+, or Cu2+ were added into Zn-ShMT.	Zinc	236-238	CD2 molecule	Homo sapiens	200-203
31918077-6	2020	Although both the reconstructed apo-ShMT and substituted Zn-ShMT with three metal ions fitted the same M6II- and M7I-ShMT binding models for divalent and monovalent metals, the differences in their thermodynamic data suggested that discrepancies exit in their physiological functions.	Zinc	57-59	serine hydroxymethyltransferase 1	Homo sapiens	60-64
31918077-6	2020	Although both the reconstructed apo-ShMT and substituted Zn-ShMT with three metal ions fitted the same M6II- and M7I-ShMT binding models for divalent and monovalent metals, the differences in their thermodynamic data suggested that discrepancies exit in their physiological functions.	Zinc	57-59	serine hydroxymethyltransferase 1	Homo sapiens	60-64
31918077-7	2020	These results suggested that ShMT yielded in vivo had a higher storage capability for Zn2+ and a uptake ability for Cd2+, and Zn-ShMT was more easy to release Zn2+ as well as to uptake Cd2+, Cu2+, or Pb2+.	Zinc	86-90	serine hydroxymethyltransferase 1	Homo sapiens	29-33
31918077-7	2020	These results suggested that ShMT yielded in vivo had a higher storage capability for Zn2+ and a uptake ability for Cd2+, and Zn-ShMT was more easy to release Zn2+ as well as to uptake Cd2+, Cu2+, or Pb2+.	Zinc	86-88	serine hydroxymethyltransferase 1	Homo sapiens	29-33
24304836-9	2014	Hepcidin treatment of oocytes inhibited efflux of (55)Fe, (65)Zn, and (57)Co.	Zinc	62-64	hepcidin antimicrobial peptide	Homo sapiens	0-8
31918077-7	2020	These results suggested that ShMT yielded in vivo had a higher storage capability for Zn2+ and a uptake ability for Cd2+, and Zn-ShMT was more easy to release Zn2+ as well as to uptake Cd2+, Cu2+, or Pb2+.	Zinc	159-163	serine hydroxymethyltransferase 1	Homo sapiens	29-33
24420568-6	2014	Zn deprivation had a very limited effect on transcript levels of Pi-starvation-responsive genes such as AT4, IPS1, and microRNA399, or on of members of the high-affinity Pi transporter family PHT1.	Zinc	0-2	induced by phosphate starvation1	Arabidopsis thaliana	109-113
31918077-7	2020	These results suggested that ShMT yielded in vivo had a higher storage capability for Zn2+ and a uptake ability for Cd2+, and Zn-ShMT was more easy to release Zn2+ as well as to uptake Cd2+, Cu2+, or Pb2+.	Zinc	159-163	serine hydroxymethyltransferase 1	Homo sapiens	129-133
32320662-4	2020	NC-Zn2+ ejection reverses the HIV-1 blockade on SG assembly, inhibits NC-SG assembly, disrupts NC/Gag-genomic RNA (vRNA) ribonucleoprotein complexes, and causes nuclear sequestration of NC and the vRNA, inhibiting Gag expression and virus release.	Zinc	3-7	vault RNA 1-1	Homo sapiens	115-119
32320662-4	2020	NC-Zn2+ ejection reverses the HIV-1 blockade on SG assembly, inhibits NC-SG assembly, disrupts NC/Gag-genomic RNA (vRNA) ribonucleoprotein complexes, and causes nuclear sequestration of NC and the vRNA, inhibiting Gag expression and virus release.	Zinc	3-7	vault RNA 1-1	Homo sapiens	197-201
23681976-0	2014	A novel phosphorescence sensor for Co2+ ion based on Mn-doped ZnS quantum dots.	Zinc	62-65	complement C2	Homo sapiens	35-38
31119572-5	2020	Multivariate statistical analysis (principle component analysis) identifies two dominant components, PC1: As, Cr, Cu, Pb and Zn, as well as PC2: Ni, Co and total organic carbon.	Zinc	125-127	polycystin 1, transient receptor potential channel interacting	Homo sapiens	101-104
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-4
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	matrix metallopeptidase 3	Mus musculus	82-86
31057077-6	2020	1T64 (HDAC8 in complex with TSA) was found to show the highest stability over time, presumably because of the TSA"s ability to span HDAC8 catalytic channel and form a strong ionic interaction with zinc metal ion.	Zinc	197-207	histone deacetylase 8	Homo sapiens	6-11
24356796-9	2014	Proteomic analysis of one of the commonly seen fluorescing regions showed the possibility for some dyes to recognize Zn and Cu bound to metallothionein 2.	Zinc	117-119	metallothionein 2A	Homo sapiens	136-153
24694605-10	2014	Placental soluble Ob-R mRNA expression also decreased in Zn-deficient mice and tended to increase in Zn-supplemented mice.	Zinc	57-59	leptin receptor	Mus musculus	18-22
32597135-10	2020	The third SNP, rs1610216 (MT2A -209A/G), has been studied for association with type 2 diabetes, cardiomyopathy, hyperglycaemia, and Zn concentrations.	Zinc	132-134	metallothionein 2A	Homo sapiens	26-30
31794081-1	2020	A new triazole functionalized tetracarboxylic acid ligand (H4L) has been synthesized and utilized for the fabrication of a 3D Zn(II) organic framework with a Zn4(-COO)6 cluster as the SBU.	Zinc	126-132	H4 clustered histone 7	Homo sapiens	59-62
31794081-1	2020	A new triazole functionalized tetracarboxylic acid ligand (H4L) has been synthesized and utilized for the fabrication of a 3D Zn(II) organic framework with a Zn4(-COO)6 cluster as the SBU.	Zinc	158-168	H4 clustered histone 7	Homo sapiens	59-62
31969116-7	2020	Furthermore, for lower Zn/Cd concentrations changes were noted for NtZIP5A/B and NtZIP5-like only, but at higher Zn and Cd levels for NtZIP1-like, NtZIP5-like, NtZIP8, NtZIP11, NtIRT1, and NtIRT1-like.	Zinc	23-25	probable zinc transporter 10	Nicotiana tabacum	177-183
31969116-7	2020	Furthermore, for lower Zn/Cd concentrations changes were noted for NtZIP5A/B and NtZIP5-like only, but at higher Zn and Cd levels for NtZIP1-like, NtZIP5-like, NtZIP8, NtZIP11, NtIRT1, and NtIRT1-like.	Zinc	23-25	probable zinc transporter 10	Nicotiana tabacum	189-195
31854993-0	2020	Tandem Carbenoid C-H Functionalization/Conia-ene Cyclization of N-Propargyl Indoles Generates Pyrroloindoles under Cooperative Rh(II)/Zn(II) Catalysis.	Zinc	134-140	Rh blood group D antigen	Homo sapiens	127-133
31272355-6	2020	Furthermore, the binding of Zn2+ by amyloid beta causes a disruption of zincergic signaling, and recent studies point to GPR39 and its intracellular targets being affected by amyloid pathology.	Zinc	28-32	G protein-coupled receptor 39	Homo sapiens	121-126
31272355-7	2020	In this review, we present neurobiological findings related to Zn2+ and GPR39, focusing on its signaling pathways, neural plasticity, interactions with other neurotransmission systems, as well as on the effects of pathophysiological changes observed in Alzheimer"s disease on GPR39 function.	Zinc	63-67	G protein-coupled receptor 39	Homo sapiens	276-281
31696764-1	2020	Earlier, we demonstrated that transcript levels of METAL TOLERANCE PROTEIN2 (MTP2) and of HEAVY METAL ATPase2 (HMA2) increase strongly in roots of Arabidopsis upon prolonged zinc (Zn) deficiency and respond to shoot physiological Zn status, and not to the local Zn status in roots.	Zinc	180-182	heavy metal atpase 2	Arabidopsis thaliana	90-109
31696764-1	2020	Earlier, we demonstrated that transcript levels of METAL TOLERANCE PROTEIN2 (MTP2) and of HEAVY METAL ATPase2 (HMA2) increase strongly in roots of Arabidopsis upon prolonged zinc (Zn) deficiency and respond to shoot physiological Zn status, and not to the local Zn status in roots.	Zinc	180-182	heavy metal atpase 2	Arabidopsis thaliana	111-115
31696764-1	2020	Earlier, we demonstrated that transcript levels of METAL TOLERANCE PROTEIN2 (MTP2) and of HEAVY METAL ATPase2 (HMA2) increase strongly in roots of Arabidopsis upon prolonged zinc (Zn) deficiency and respond to shoot physiological Zn status, and not to the local Zn status in roots.	Zinc	230-232	heavy metal atpase 2	Arabidopsis thaliana	90-109
31696764-1	2020	Earlier, we demonstrated that transcript levels of METAL TOLERANCE PROTEIN2 (MTP2) and of HEAVY METAL ATPase2 (HMA2) increase strongly in roots of Arabidopsis upon prolonged zinc (Zn) deficiency and respond to shoot physiological Zn status, and not to the local Zn status in roots.	Zinc	230-232	heavy metal atpase 2	Arabidopsis thaliana	90-109
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	zinc transporter 3 precursor	Arabidopsis thaliana	136-140
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	zinc transporter	Arabidopsis thaliana	148-152
31746596-1	2019	Eukaryotic histone deacetylase 10 (HDAC10) is a Zn2+-dependent hydrolase that exhibits catalytic specificity for the hydrolysis of the polyamine N8-acetylspermidine.	Zinc	48-52	histone deacetylase 10	Danio rerio	11-33
31746596-1	2019	Eukaryotic histone deacetylase 10 (HDAC10) is a Zn2+-dependent hydrolase that exhibits catalytic specificity for the hydrolysis of the polyamine N8-acetylspermidine.	Zinc	48-52	histone deacetylase 10	Danio rerio	35-41
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	lactotransferrin	Bos taurus	38-40
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	60-62	lactotransferrin	Bos taurus	38-40
30783921-7	2019	It is concluded that Zn supplementation has an impact on the immuno-modulation of bovine LF, while Zn-saturation is a key factor to modulate these assessed immune activities.	Zinc	21-23	lactotransferrin	Bos taurus	89-91
31586897-7	2019	Our experiments indicate a strong synergistic interaction between ZnO and PANI, resulting in the magnification of PP current with a declined over-potential, compared to bare CPE.	Zinc	66-69	carboxypeptidase E	Homo sapiens	174-177
31776425-0	2019	Zn2+ stimulates salivary secretions via metabotropic zinc receptor ZnR/GPR39 in human salivary gland cells.	Zinc	0-4	G protein-coupled receptor 39	Homo sapiens	71-76
31776425-2	2019	Zn2+ can evoke G-protein-coupled receptor signaling via activation of the metabotropic zinc receptor ZnR/GPR39.	Zinc	0-4	G protein-coupled receptor 39	Homo sapiens	105-110
31776425-9	2019	As with muscarinic agonist, Zn2+ also induced the translocation of aquaporin-5 (AQP-5) to the plasma membrane, which was drastically decreased in ZnR/GPR39-knockdown cells.	Zinc	28-32	aquaporin 5	Homo sapiens	67-78
31776425-9	2019	As with muscarinic agonist, Zn2+ also induced the translocation of aquaporin-5 (AQP-5) to the plasma membrane, which was drastically decreased in ZnR/GPR39-knockdown cells.	Zinc	28-32	aquaporin 5	Homo sapiens	80-85
31776425-9	2019	As with muscarinic agonist, Zn2+ also induced the translocation of aquaporin-5 (AQP-5) to the plasma membrane, which was drastically decreased in ZnR/GPR39-knockdown cells.	Zinc	28-32	G protein-coupled receptor 39	Homo sapiens	150-155
31682454-3	2019	Aluminum matrix superhydrophobic surface (STA-PDMS-ZnO sample) was able to display excellent repellency to water with a WCA of 152  and a WSA of 2 .	Zinc	51-54	GCY	Homo sapiens	42-45
31682454-5	2019	Due to the special surface structure, the mechanical robustness and corrosion resistance of STA-PDMS-ZnO sample were improved.	Zinc	101-104	GCY	Homo sapiens	92-95
31682454-7	2019	The superhydrophobic surface with multilayered micro&amp;nano-structure (STA-PDMS-ZnO sample) showed greater corrosion resistance than the surface coated by superhydrophobic modification (Control sample).	Zinc	82-85	GCY	Homo sapiens	73-76
31726734-1	2019	Ultrasound-assisted transient liquid phase bonding (U-TLP) has been regarded as a promising brazing process to join magnesium alloys with a Sn and Zn interlayer; however, the formation of brittle magnesium intermetallic compounds (Mg2Sn, MgZn, and MgZn2) compromises the mechanical properties of the joints.	Zinc	147-149	cysteine rich protein 3	Homo sapiens	54-57
31376766-2	2019	In this study, ZnS nanoparticles with an average size around 10-15 nm were synthesised by a facile hydrothermal method, and then hybridised with g-C3N4 (MCN, DCN, and UCN) derived from melamine, dicyandiamide and urea, producing the heterojunctions denoted as ZMCN, ZDCN and ZUCN, respectively.	Zinc	15-18	urocortin	Homo sapiens	167-170
25462065-8	2014	HO-1 mRNA expression was measured as a downstream marker of response to oxidative stress induced by Zn(2+) exposure.	Zinc	100-103	heme oxygenase 1	Homo sapiens	0-4
25462065-10	2014	Compartment-directed catalase expression blunted Zn(2+)-induced elevations in cytosolic EGSH and the increased expression of HO-1 mRNA levels.	Zinc	49-51	heme oxygenase 1	Homo sapiens	125-129
31641177-1	2019	The selected and controlled preparation of core@shell nanostructures, which unite the multiple functions of ferromagnetic Ni-Zn ferrite core and CdS shell in a single material with tuneable fluorescence and magnetic properties, have been proposed by the seed mediated aqueous growth process.	Zinc	122-135	CDP-diacylglycerol synthase 1	Homo sapiens	145-148
32954262-5	2019	In this study, we show that the deletion of YPK9 (the yeast orthologue of ATP13A2) in Saccharomyces cerevisiae leads to growth impairment in the presence of Zn2+, Mn2+, Co2+ and Ni2+, with the strongest phenotype being observed in the presence of zinc.	Zinc	157-161	ATPase cation transporting 13A2	Danio rerio	74-81
24198360-0	2013	The GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia.	Zinc	53-57	glycine receptor alpha 1	Homo sapiens	4-9
24198360-4	2013	Here, we report that recombinant human GlyRs containing alpha1 or alpha1beta subunits with a missense mutation in the alpha1 subunit (W170S), previously identified from familial hyperekplexia, caused remarkably reduced potentiation and enhanced inhibition by Zn(2+).	Zinc	259-261	adrenoceptor alpha 1D	Homo sapiens	56-76
24198360-9	2013	Together, our results reveal a new zinc potentiation site on alpha1 GlyRs and a strong link between Zn(2+) modulation and human disease.	Zinc	100-102	glycine receptor alpha 1	Homo sapiens	61-73
31547165-8	2019	The expression of Heavy Metal ATPase 2 (TaHMA2) and ATP-Binding Cassette (TaABCC2/3/4) metal detoxification transporters are significantly upregulated in Pirsabak 2004 compared with Fakhar-e-sarhad and non-treated controls in response to Pb, Cd and Zn metal stresses.	Zinc	249-251	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	30-38
23826687-4	2013	Mutant ozs1 represents a non-functional allele of the vacuolar Zn transporter AtMTP1, providing additional genetic evidence for its major role in Zn(2+) tolerance in seedlings.	Zinc	63-65	zinc transporter	Arabidopsis thaliana	78-84
23726800-5	2013	Moreover, Zn protected from the Cd-induced increase in sRANKL concentration and the sRANKL/OPG ratio, and decrease in OPG concentration in the bone and serum.	Zinc	10-12	TNF receptor superfamily member 11B	Rattus norvegicus	91-94
23726800-5	2013	Moreover, Zn protected from the Cd-induced increase in sRANKL concentration and the sRANKL/OPG ratio, and decrease in OPG concentration in the bone and serum.	Zinc	10-12	TNF receptor superfamily member 11B	Rattus norvegicus	118-121
23726800-8	2013	This paper is the first report from an in vivo study providing evidence that beneficial Zn impact on the skeleton under exposure to Cd is related to the improvement of the bone tissue oxidative/antioxidative status and mediating the RANK/RANKL/OPG system.	Zinc	88-90	TNF receptor superfamily member 11B	Rattus norvegicus	244-247
31547165-8	2019	The expression of Heavy Metal ATPase 2 (TaHMA2) and ATP-Binding Cassette (TaABCC2/3/4) metal detoxification transporters are significantly upregulated in Pirsabak 2004 compared with Fakhar-e-sarhad and non-treated controls in response to Pb, Cd and Zn metal stresses.	Zinc	249-251	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	40-46
30991335-6	2019	The chemical elements As, B, Bi, Cd, Cu, P, Pb, Sb, Sn and Zn (PC2) are strongly spatially associated with soils sampled above high-density urban residential, commercial and industrial sites, and are interpreted to reflect heavy metal contamination from human activities.	Zinc	59-61	chromobox 4	Homo sapiens	63-66
24058648-11	2013	CONCLUSION/SIGNIFICANCE: The gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70.	Zinc	60-69	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	188-193
31140476-2	2019	The chemosensor HL exhibits rapid visual turn-on fluorescence enhancing recognition toward Mg2+/Zn2+, which is not interfered by other cations, especially for respective congeners Ca2+/Cd2+.	Zinc	96-100	CD2 molecule	Homo sapiens	185-188
23752481-0	2013	Heparin-mediated fluorescence anisotropy assay of antithrombin based on polyethyleneimine capped Mn-doped ZnS quantum dots.	Zinc	106-109	serpin family C member 1	Homo sapiens	50-62
31104243-10	2019	We also found the decreased trends of urinary Se, Zn, and Mn quartiles with the ORs for PTC.	Zinc	50-52	coiled-coil domain containing 6	Homo sapiens	88-91
23752481-1	2013	We presented a homogeneous heparin-mediated fluorescence anisotropy (FA) assay of antithrombin (AT) based on long-lived luminescent polyethyleneimine capped Mn-doped ZnS (PEI-Mn-ZnS) QDs.	Zinc	166-169	serpin family C member 1	Homo sapiens	82-94
31104243-12	2019	Our study suggested that PTC was positively associated with urinary levels of Cd, Cu, Fe, Pb, and inversely associated with Se, Zn, and Mn.	Zinc	128-130	coiled-coil domain containing 6	Homo sapiens	25-28
31379409-8	2019	In addition, sublethal treatment with PAM induced phosphorylation of ATM kinase, accumulation of p53 protein, and expression of p21 and GADD45A, which are known p53 target genes, in a Zn2+-dependent manner.	Zinc	184-188	H3 histone pseudogene 16	Homo sapiens	128-131
23801188-1	2013	This paper reports a theoretical and experimental study of the heterostructure photocatalytic activity in a CdS or ZnS and CdS@ZnS decorated system prepared by a microwave assisted solvothermal (MAS) method.	Zinc	127-130	CDP-diacylglycerol synthase 1	Homo sapiens	123-126
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	30-33	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
31588281-8	2019	Within the next week the reaction mixture gives in high yield a diamagnetic dinuclear compound [PhZn(mu-TEMPO*)][PhZn(mu2-eta1:eta1-TEMPO*)] and biphenyl.	Zinc	96-100	secreted phosphoprotein 1	Homo sapiens	122-126
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	30-33	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
31588281-8	2019	Within the next week the reaction mixture gives in high yield a diamagnetic dinuclear compound [PhZn(mu-TEMPO*)][PhZn(mu2-eta1:eta1-TEMPO*)] and biphenyl.	Zinc	96-100	secreted phosphoprotein 1	Homo sapiens	127-131
31588281-8	2019	Within the next week the reaction mixture gives in high yield a diamagnetic dinuclear compound [PhZn(mu-TEMPO*)][PhZn(mu2-eta1:eta1-TEMPO*)] and biphenyl.	Zinc	113-117	secreted phosphoprotein 1	Homo sapiens	122-126
31588281-8	2019	Within the next week the reaction mixture gives in high yield a diamagnetic dinuclear compound [PhZn(mu-TEMPO*)][PhZn(mu2-eta1:eta1-TEMPO*)] and biphenyl.	Zinc	113-117	secreted phosphoprotein 1	Homo sapiens	127-131
30444646-6	2019	Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8.	Zinc	18-22	solute carrier family 30 member 8	Rattus norvegicus	271-275
31006963-10	2019	The SEC-ICP-MS analyses showed that ADAMTS13 only bound Zn2+ and that its reduced activity correlated with a gradual loss of bound Zn2+ .	Zinc	56-60	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	36-44
23895096-6	2013	However, Zn(2+), Mg(2+) and Mn(2+) added to a Ca(2+)- pradimicin mixture, prevented pradimicin from efficient binding to gp120 glycans.	Zinc	9-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	121-126
23420078-10	2013	Western blot and mRNA expressions of p53 and nuclear factor kappaB (NF-kappaB) were also found to be significantly elevated after Al treatment, which however, were reversed following Zn treatment.	Zinc	183-185	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	37-40
31006963-10	2019	The SEC-ICP-MS analyses showed that ADAMTS13 only bound Zn2+ and that its reduced activity correlated with a gradual loss of bound Zn2+ .	Zinc	131-135	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	36-44
31006963-12	2019	CONCLUSIONS: Zn2+ is required to stabilize ADAMTS13 structure at physiologic temperature, thereby preventing irreversible loss of enzyme activity.	Zinc	13-17	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	43-51
30746812-6	2019	Zn 2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-AC-cAMP-PKA-Src-EGFR and phospholipase C. Both the transmembrane adenylyl cyclase (AC) and the soluble-AC are involved in the stimulation of HAM by Zn 2+ .	Zinc	0-5	G protein-coupled receptor 39	Homo sapiens	91-96
30746812-6	2019	Zn 2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-AC-cAMP-PKA-Src-EGFR and phospholipase C. Both the transmembrane adenylyl cyclase (AC) and the soluble-AC are involved in the stimulation of HAM by Zn 2+ .	Zinc	245-250	G protein-coupled receptor 39	Homo sapiens	91-96
22846892-8	2013	Small angle scattering analyses revealed that the overall structure of the S100A3 tetramer bound both Ca(2+) and Zn(2+) had a similar molecular shape to the Ca(2+)-bound form in solution.	Zinc	113-119	S100 calcium binding protein A3	Homo sapiens	75-81
22846892-9	2013	The binding states of the Ca(2+) or Zn(2+) to each S100A3 subunit within a homotetramer appear to be propagated by sensing the repositioning of helix III and the rearrangement of the C-terminal tail domain.	Zinc	36-38	S100 calcium binding protein A3	Homo sapiens	51-57
30746812-10	2019	These data support a role for extracellular Zn 2+ acting via GPR39 to regulate signaling pathways in sperm capacitation, leading to HAM induction.	Zinc	44-49	G protein-coupled receptor 39	Homo sapiens	61-66
30900874-3	2019	The binding of catalytically competent divalent cation-dNTP complexes to RT-P/T was measured with Mg2+, Mn2+, Zn2+, Co2+, and Ni2+ using Ca2+, a noncatalytic cation, for displacement.	Zinc	110-114	MORN repeat containing 4	Homo sapiens	73-79
24024362-5	2013	RESULTS: Exposure of BEAS-2B cells to Zn2+ inhibited phosphatase activity of PTEN, as well as PTEN phosphorylation, indicative of PTEN activity (P &lt; 0.05).	Zinc	38-42	phosphatase and tensin homolog	Homo sapiens	77-81
24024362-5	2013	RESULTS: Exposure of BEAS-2B cells to Zn2+ inhibited phosphatase activity of PTEN, as well as PTEN phosphorylation, indicative of PTEN activity (P &lt; 0.05).	Zinc	38-42	phosphatase and tensin homolog	Homo sapiens	94-98
24024362-5	2013	RESULTS: Exposure of BEAS-2B cells to Zn2+ inhibited phosphatase activity of PTEN, as well as PTEN phosphorylation, indicative of PTEN activity (P &lt; 0.05).	Zinc	38-42	phosphatase and tensin homolog	Homo sapiens	94-98
24024362-8	2013	CONCLUSION: These results suggested that Zn2+ exposure might inhibit PTEN phosphatase activity through inhibition of CK-2 activity in human airway epithelial cells.	Zinc	41-45	phosphatase and tensin homolog	Homo sapiens	69-73
30791479-6	2019	More recently, the induction of endogenous expression of the Zn and Cu binding protein, metallothionein, by the glucocorticoid analogue, dexamethasone, gave a specific reduction in Cu-dependent alpha-syn aggregates.	Zinc	61-63	synuclein alpha	Homo sapiens	194-203
23672184-6	2013	As synthesized Cd(0.9)Zn(0.1)S shows 2-fold enhancement in degradation of methylene blue as compared to the bulk CdS.	Zinc	22-24	CDP-diacylglycerol synthase 1	Homo sapiens	113-116
30714062-0	2019	Insights into the ion-exchange properties of Zn(ii)-incorporated MOR zeolites for the capture of multivalent cations.	Zinc	45-51	opioid receptor mu 1	Homo sapiens	65-68
23294838-4	2013	Zinc/cadmium (Zn/Cd) resistance was observed in TaHMA2-transformed yeast.	Zinc	14-16	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	48-54
23294838-9	2013	The over-expression of TaHMA2 improved plant tolerance under moderate Zn stress and Zn deficiency, but Zn and Cd resistance decreased under high levels of Zn and Cd stress, respectively.	Zinc	70-72	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	23-29
23294838-9	2013	The over-expression of TaHMA2 improved plant tolerance under moderate Zn stress and Zn deficiency, but Zn and Cd resistance decreased under high levels of Zn and Cd stress, respectively.	Zinc	84-86	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	23-29
30714062-2	2019	We synthesized a Zn(ii)-incorporated mordenite-framework aluminosilicate zeolite (Zn,Al-MOR), in which both Zn and Al are substituted in the framework, and studied its ion-exchange behavior for multivalent cations.	Zinc	17-23	opioid receptor mu 1	Homo sapiens	88-91
23294838-9	2013	The over-expression of TaHMA2 improved plant tolerance under moderate Zn stress and Zn deficiency, but Zn and Cd resistance decreased under high levels of Zn and Cd stress, respectively.	Zinc	84-86	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	23-29
30714062-2	2019	We synthesized a Zn(ii)-incorporated mordenite-framework aluminosilicate zeolite (Zn,Al-MOR), in which both Zn and Al are substituted in the framework, and studied its ion-exchange behavior for multivalent cations.	Zinc	17-19	opioid receptor mu 1	Homo sapiens	88-91
23055406-4	2013	In S. cerevisiae, the expression of a chimeric derivative of the AVP1 and OVP1 alleviated the phenotype associated with ipp2-deficient cells in the presence of high salinity (NaCl) and metal stressors (Cd, Mn, and Zn).	Zinc	214-216	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	65-69
30714062-5	2019	Herein, we discussed the mechanism responsible for improving the ion-exchange performance in the presence of Zn(ii) and found that the incorporation of Zn(ii) led to a significant improvement in the ion-exchange temperature dependence of the MOR, which led to the ability to enhance ion-exchange capacity through temperature control during actual application.	Zinc	109-112	opioid receptor mu 1	Homo sapiens	242-245
30714062-5	2019	Herein, we discussed the mechanism responsible for improving the ion-exchange performance in the presence of Zn(ii) and found that the incorporation of Zn(ii) led to a significant improvement in the ion-exchange temperature dependence of the MOR, which led to the ability to enhance ion-exchange capacity through temperature control during actual application.	Zinc	152-155	opioid receptor mu 1	Homo sapiens	242-245
30714133-1	2019	The present study examined the involvement of zinc (Zn)-transporters (ZnT3) in cadmium (Cd)-induced alterations of Zn homeostasis in rat hippocampal neurons.	Zinc	52-54	solute carrier family 30 member 3	Rattus norvegicus	70-74
23055406-4	2013	In S. cerevisiae, the expression of a chimeric derivative of the AVP1 and OVP1 alleviated the phenotype associated with ipp2-deficient cells in the presence of high salinity (NaCl) and metal stressors (Cd, Mn, and Zn).	Zinc	214-216	inorganic diphosphatase PPA2	Saccharomyces cerevisiae S288C	120-124
23055406-5	2013	In E. coli, AVP1 and OVP1 overexpression conferred enhanced tolerance to abiotic stresses, including heat shock and H(2)O(2), as well as NaCl, Cd, Mn, Zn, Ca, and Al.	Zinc	151-153	Inorganic H pyrophosphatase family protein	Arabidopsis thaliana	12-16
30672309-1	2019	AIM: To generate a combination of serum zinc (Zn) and prostate-specific antigen (PSA) in an attempt to provide better prediction of prostate biopsy outcomes with Zn/PSA ratios.	Zinc	162-164	kallikrein related peptidase 3	Homo sapiens	81-84
23320490-1	2013	The structural change and resilience of a single crystal of a metal-organic framework (MOF), Zn(HO(3)PC(4)H(8)PO(3)H) 2H(2)O (ZAG-4), was investigated under high pressures (0-9.9 GPa) using in situ single crystal X-ray diffraction.	Zinc	93-95	DSCAM intronic transcript 1	Homo sapiens	126-131
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Zinc	257-261	carbonic anhydrase 1	Rattus norvegicus	8-11
23272701-1	2013	The plant metallothionein2 from Cicer arietinum (chickpea), cic-MT2, is known to coordinate five divalent metal ions such as Zn(II) or Cd(II), which are arranged in a single metal thiolate cluster.	Zinc	125-131	metallothionein-like protein 2	Cicer arietinum	64-67
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Zinc	257-261	carbonic anhydrase 1	Rattus norvegicus	64-67
22978548-0	2012	By increasing the affinity of heparin for fibrin, Zn(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin.	Zinc	50-56	serpin family C member 1	Homo sapiens	167-179
22978548-8	2012	Therefore, by enhancing the binding of heparin to fibrin, physiological concentrations of Zn(2+) render fibrin-bound thrombin more protected from inhibition by antithrombin.	Zinc	90-96	serpin family C member 1	Homo sapiens	160-172
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Zinc	337-341	carbonic anhydrase 1	Rattus norvegicus	8-11
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Zinc	337-341	carbonic anhydrase 1	Rattus norvegicus	64-67
30581142-3	2019	Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn2+ entry through the Zip1-MCU complex.	Zinc	177-181	dynamin 1 like	Homo sapiens	68-72
22803592-2	2012	To explain the structural basis of metal ion binding specificity, we have determined the X-ray structures of the N-terminal domain of calmodulin (N-CaM) in complexes with Mg(2+), Mn(2+), and Zn(2+).	Zinc	191-193	neural cell adhesion molecule 1	Homo sapiens	146-151
30581142-3	2019	Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn2+ entry through the Zip1-MCU complex.	Zinc	177-181	solute carrier family 39 member 1	Homo sapiens	200-204
22465770-0	2012	Synthesis and optical characterization of single phased ZnS:Mn2+/CdS core-shell nanoparticles.	Zinc	56-59	CDP-diacylglycerol synthase 1	Homo sapiens	65-68
30261431-4	2019	The competitive experiments were found to be highly selective for the Cd2+ ions even in the existence of excess competing metal ions including Zn2+, Pb2+, Hg2+ and Cu2+ ions.	Zinc	143-147	CD2 molecule	Homo sapiens	70-73
22367497-5	2012	The obtained results showed that rapid increase of [Zn(2+)]( i ) in the cytoplasm up-regulates metallothionein MtnB but not MtnA gene expression in cells treated with Zn(2+) in both concentrations.	Zinc	52-58	Metallothionein B	Drosophila melanogaster	111-115
22367497-5	2012	The obtained results showed that rapid increase of [Zn(2+)]( i ) in the cytoplasm up-regulates metallothionein MtnB but not MtnA gene expression in cells treated with Zn(2+) in both concentrations.	Zinc	167-173	Metallothionein B	Drosophila melanogaster	111-115
22625223-5	2012	RESULTS: After 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P &lt; 0.001), IGF-1 (P &lt; 0.01), IGF-1 standard deviation score (SDS, P &lt; 0.01) and IGFBP-3 (P = 0.042).	Zinc	27-29	insulin like growth factor binding protein 3	Homo sapiens	258-265
22441041-2	2012	In a recent study, we showed that Zn(2+) regulates GABA(A) reversal potentials in the hippocampus by enhancing the activity of KCC2 through an increase in its surface expression.	Zinc	34-36	solute carrier family 12 member 5	Rattus norvegicus	127-131
22441041-8	2012	We observed that Zn(2+) pretreatment induced a Ca(2+)-dependent increase in KCC2 activity.	Zinc	17-23	solute carrier family 12 member 5	Rattus norvegicus	76-80
22441041-9	2012	The effects of Zn(2+) on KCC2 activity were also observed in wild-type mouse cortical neurons in culture, but not in neurons obtained from mZnR/GPR39(-/-) mice, suggesting that Zn(2+) acts through mZnR/GPR39 activation to upregulate KCC2 activity.	Zinc	15-17	solute carrier family 12, member 5	Mus musculus	25-29
22441041-12	2012	Non-transfected cells, or cells transfected with marker vector alone, showed a Zn(2+)-dependent increase in KCC2 activity.	Zinc	79-85	solute carrier family 12 member 5	Rattus norvegicus	108-112
33418810-7	2018	Moreover, with the synergistic functions of Zn and Mg ions, cells on the composite coating showed a higher level of alkaline phosphatase activity and expression of osteopontin (OPN).	Zinc	44-46	AT695_RS04080	Staphylococcus aureus	116-136
30187212-0	2018	Zn2+-binding in the glutamate-rich region of the intrinsically disordered protein prothymosin-alpha.	Zinc	0-4	prothymosin alpha pseudogene 9	Homo sapiens	82-99
21947794-5	2012	Studies have suggested an association between Zn and leptin status in human and rats; however, the results are inconsistent.	Zinc	46-48	leptin	Homo sapiens	53-59
21947794-7	2012	Others have reported that Zn might be a mediator of leptin production.	Zinc	26-28	leptin	Homo sapiens	52-58
21935692-8	2012	Expression of PARP, p53 and OGG1 measured by western blotting was increased in Zn-depleted cells indicating that DNA repair mechanisms are activated.	Zinc	79-81	8-oxoguanine DNA glycosylase	Homo sapiens	28-32
30187212-1	2018	Prothymosin-alpha is a small, multifunctional intrinsically disordered protein associated with cell survival and proliferation which binds multiple Zn2+ ions and undergoes partial folding.	Zinc	148-152	prothymosin alpha pseudogene 9	Homo sapiens	0-17
30187212-2	2018	The interaction between prothymosin-alpha and at least two of its protein targets is significantly enhanced in the presence of Zn2+ ions, suggesting that Zn2+ binding plays a role in the protein"s function.	Zinc	127-131	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-2	2018	The interaction between prothymosin-alpha and at least two of its protein targets is significantly enhanced in the presence of Zn2+ ions, suggesting that Zn2+ binding plays a role in the protein"s function.	Zinc	154-158	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-4	2018	To gain a better understanding of the nature of the Zn2+-prothymosin-alpha interactions and the protein"s ability to discriminate Zn2+ over other divalent cations (e.g., Ca2+, Co2+, Mg2+) we synthesized a set of three model peptides and characterized the effect of metal binding using electrospray ionization mass spectrometry (ESI MS) and circular dichroism (CD) spectroscopy.	Zinc	52-56	prothymosin alpha pseudogene 9	Homo sapiens	57-74
22108899-8	2012	However, Zn supplementation to Al-treated rats was able to reduce significantly the Al-induced increased activities of G6P, G6I, and LDH, but it elevated the levels of hexokinase, SDH, and glycogen.	Zinc	9-11	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	119-122
29496417-12	2018	Cows supplemented with combination of Zn and VE showed minimum decline in plasma concentration of leptin, insulin, GH, IGF-1, T3, and T4, and minimum increase in cortisol concentration.	Zinc	38-40	insulin	Bos taurus	106-113
22306774-0	2012	Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress.	Zinc	39-43	carbonic anhydrase 1	Rattus norvegicus	84-87
22306774-4	2012	In the present study, involvement of synaptic Zn(2+) in stress-induced attenuation of CA1 LTP was examined in hippocampal slices from young rats after exposure to tail suspension stress for 30s, which significantly increased serum corticosterone.	Zinc	46-48	carbonic anhydrase 1	Rattus norvegicus	86-89
29496417-12	2018	Cows supplemented with combination of Zn and VE showed minimum decline in plasma concentration of leptin, insulin, GH, IGF-1, T3, and T4, and minimum increase in cortisol concentration.	Zinc	38-40	insulin like growth factor 1	Bos taurus	119-124
22306774-5	2012	Stress-induced attenuation of CA1 LTP was ameliorated by administration of clioquinol, a membrane permeable zinc chelator, to rats prior to exposure to stress, implying that the reduction of synaptic Zn(2+) by clioquinol participates in this amelioration.	Zinc	200-202	carbonic anhydrase 1	Rattus norvegicus	30-33
22306774-6	2012	To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone.	Zinc	53-59	carbonic anhydrase 1	Rattus norvegicus	85-88
30397150-4	2018	This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of the Zn importer ZIP1 (target of miR-182), leading to a reduction of prostatic Zn.	Zinc	117-119	solute carrier family 39 member 1	Homo sapiens	249-253
22306774-10	2012	The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress.	Zinc	81-87	carbonic anhydrase 1	Rattus norvegicus	158-161
30397150-5	2018	This inverse relationship between miR-182 and ZIP1 also occurs in human prostate cancer tissue, which is known for Zn loss.	Zinc	115-117	solute carrier family 39 member 1	Homo sapiens	46-50
30397150-6	2018	The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer.	Zinc	23-25	solute carrier family 39 member 1	Homo sapiens	344-348
30005378-1	2018	In this work, a new "signal-on" split-type photoelectrochemical (PEC) sensing platform for prostate-specific antigen (PSA) detection was successfully constructed using p-type Cu-doped Zn0.3Cd0.7S as the photosensitive semiconductor material and target-triggered rolling circle amplification (RCA) for signal amplification.	Zinc	184-187	kallikrein related peptidase 3	Homo sapiens	91-122
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Zinc	415-417	synaptosome associated protein 25	Homo sapiens	59-65
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Zinc	415-417	synaptosome associated protein 25	Homo sapiens	101-107
29954510-0	2018	CdS/ZnS Heterostructured Porous Composite with Enhanced Visible Light Photocatalysis.	Zinc	4-7	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
22178664-2	2012	This paper presents the full 384-388-atom structures of the two native Zn(II)- and the Cd(II)-containing domains of human MT2, optimized with density functional theory.	Zinc	71-77	metallothionein 2A	Homo sapiens	122-125
29954510-2	2018	Here we present a facile design to fabricate novel CdS/ZnS heterostructured porous sheet-like nanocomposite based on a cation-exchanged hydrothermal procedure.	Zinc	55-58	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
22393314-1	2012	BACKGROUND: Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status.	Zinc	98-100	leptin	Homo sapiens	55-61
23251339-7	2012	Zn deficiency exacerbated hepatic injuries, shown by further increased serum ALT, hepatic lipid accumulation, inflammation, oxidative damage, and endoplasmic reticulum stress-related cell death in Diabetes/TPEN group compared to Diabetes alone.	Zinc	0-2	glutamic pyruvic transaminase, soluble	Mus musculus	77-80
29954510-6	2018	The enhanced photocatalytic activity was presumed to result from the direct photoinduced interfacial charge transfer (IFCT) from the valence band (VB) of ZnS to CdS.	Zinc	154-157	CDP-diacylglycerol synthase 1	Homo sapiens	161-164
29381217-2	2018	The aim of the present study on hydroponically grown barley (Hordeum vulgare) was to test whether any reduction in root hydraulic conductivity (Lp) in response to Zn treatment is accompanied by a reduction in cell Lp and gene expression level of aquaporin (AQP) isoforms.	Zinc	163-165	HvPIP2;3	Hordeum vulgare	246-255
22018863-10	2011	PC1 represented SPFs of Cd, Cr, Cu, Pb and Zn, while PC2 represented SPFs of Ni and Co.	Zinc	43-45	polycystin 1, transient receptor potential channel interacting	Homo sapiens	0-3
22047639-0	2011	Determination of pyrimidine and purine bases by reversed-phase capillary liquid chromatography with at-line surface-enhanced Raman spectroscopic detection employing a novel SERS substrate based on ZnS/CdSe silver-quantum dots.	Zinc	197-200	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	173-177
22047639-1	2011	We have developed a new SERS substrate based on the reduction of silver nitrate in the presence of ZnS-capped CdSe quantum dots.	Zinc	99-102	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	24-28
21873044-1	2011	A novel, highly sensitive amperometric biosensor for detection of organophosphorus (OP) compounds has been constructed, based on rat brain acetylcholinesterase (AChE) immobilized onto nanocomposite of ZnS-nanoparticles (ZnSNPs) and poly(indole-5-carboxylic acid) electrodeposited on Au electrode.	Zinc	201-204	acetylcholinesterase	Rattus norvegicus	139-159
21873044-1	2011	A novel, highly sensitive amperometric biosensor for detection of organophosphorus (OP) compounds has been constructed, based on rat brain acetylcholinesterase (AChE) immobilized onto nanocomposite of ZnS-nanoparticles (ZnSNPs) and poly(indole-5-carboxylic acid) electrodeposited on Au electrode.	Zinc	201-204	acetylcholinesterase	Rattus norvegicus	161-165
21767559-3	2011	The aim of this study was to investigate the association between the metallothionein 2A (MT2A) core promoter region -5 A/G single nucleotide polymorphism (SNP) and Cd, Pb, Zn and Cu levels in the blood samples.	Zinc	172-174	metallothionein 2A	Homo sapiens	69-87
21767559-3	2011	The aim of this study was to investigate the association between the metallothionein 2A (MT2A) core promoter region -5 A/G single nucleotide polymorphism (SNP) and Cd, Pb, Zn and Cu levels in the blood samples.	Zinc	172-174	metallothionein 2A	Homo sapiens	89-93
21767559-6	2011	As a result; highly statistically significant associations were detected between the -5 A/G core promoter region SNP in the MT2A gene and Cd, Pb and Zn levels (p=0.004, p=0.012 and p=0.002, respectively), but no association was found with Cu level (p=0.595).	Zinc	149-151	metallothionein 2A	Homo sapiens	124-128
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	75-79	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	24-31
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	75-79	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	32-38
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	148-152	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	24-31
21939532-3	2011	Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Abeta) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Abeta contributes to ProSAP/Shank platform malformation.	Zinc	148-152	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	24-31
21939532-6	2011	However, application of soluble Abeta prevented association of Zn2+ ions with ProSAP2/Shank3 in a cell-based assay and decreased the concentration of Zn2+ clusters within dendrites.	Zinc	63-67	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	78-85
21939532-6	2011	However, application of soluble Abeta prevented association of Zn2+ ions with ProSAP2/Shank3 in a cell-based assay and decreased the concentration of Zn2+ clusters within dendrites.	Zinc	63-67	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	86-92
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	0-4	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	155-162
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	0-4	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	163-169
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	49-53	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	155-162
21939532-7	2011	Zn2+ supplementation or saturation of Abeta with Zn2+ ions prior to cell treatment was able to counter the effects induced by Abeta on synapse density and ProSAP2/Shank3 levels at the PSD.	Zinc	49-53	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	163-169
21939532-8	2011	Interestingly, intracellular Zn2+ levels in APP-PS1 mice and human AD hippocampus are reduced along with a reduction in synapse density and synaptic ProSAP2/Shank3 and Shank1 protein levels.	Zinc	29-33	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	149-156
21939532-8	2011	Interestingly, intracellular Zn2+ levels in APP-PS1 mice and human AD hippocampus are reduced along with a reduction in synapse density and synaptic ProSAP2/Shank3 and Shank1 protein levels.	Zinc	29-33	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	157-163
21939532-9	2011	CONCLUSIONS: We conclude that sequestration of Zn2+ ions by Abeta significantly contributes to changes in ProSAP2/Shank3 platforms.	Zinc	47-51	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	106-113
21939532-9	2011	CONCLUSIONS: We conclude that sequestration of Zn2+ ions by Abeta significantly contributes to changes in ProSAP2/Shank3 platforms.	Zinc	47-51	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	114-120
21702491-8	2011	In high-water-content (CH(3)CN/H(2)O = 5/95, v/v) aqueous solution compound 2 shows a selective "turn-on" response toward Zn(2+), with a 10-fold enhancement in the fluorescence intensity at 428 nm and a 62 nm blue shift of the emission maximum (490 to 428 nm) due to the inhibition of intermolecular PPT process upon chelating with Zn(2+).	Zinc	122-124	palmitoyl-protein thioesterase 1	Homo sapiens	300-303
21702491-8	2011	In high-water-content (CH(3)CN/H(2)O = 5/95, v/v) aqueous solution compound 2 shows a selective "turn-on" response toward Zn(2+), with a 10-fold enhancement in the fluorescence intensity at 428 nm and a 62 nm blue shift of the emission maximum (490 to 428 nm) due to the inhibition of intermolecular PPT process upon chelating with Zn(2+).	Zinc	332-334	palmitoyl-protein thioesterase 1	Homo sapiens	300-303
21574551-5	2011	Using fluorescence anisotropy, we demonstrate that Fe(II)-ZIF268-3D binds selectively to its target DNA in the same manner as Zn(II)-ZIF268-3D.	Zinc	126-132	early growth response 1	Homo sapiens	133-139
21574551-8	2011	Similarly, Zn(II)-ZIF268-3D and apo-ZIF268-3D are rapidly oxidized by H(2)O(2) or O(2), and we propose that ZIF268-3D is highly susceptible to oxidation.	Zinc	11-17	early growth response 1	Homo sapiens	18-24
21377473-0	2011	Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.	Zinc	43-49	S100 calcium binding protein A3	Homo sapiens	58-64
21377473-1	2011	S100A3, a member of the EF-hand-type Ca(2+)-binding S100 protein family, is unique in its exceptionally high cysteine content and Zn(2+) affinity.	Zinc	130-132	S100 calcium binding protein A3	Homo sapiens	0-6
21467744-3	2011	Previously, we had reported that Zn induced the formation of a co-activator complex containing metal response element-binding transcription factor-1 (MTF-1) and the histone acetyltransferase (HAT), p300, which plays an essential role in the activation of MT-1 transcription.	Zinc	33-35	metal response element binding transcription factor 1	Mus musculus	95-148
21467744-3	2011	Previously, we had reported that Zn induced the formation of a co-activator complex containing metal response element-binding transcription factor-1 (MTF-1) and the histone acetyltransferase (HAT), p300, which plays an essential role in the activation of MT-1 transcription.	Zinc	33-35	metal response element binding transcription factor 1	Mus musculus	150-155
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	47-49	metal response element binding transcription factor 1	Mus musculus	125-130
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	95-97	metal response element binding transcription factor 1	Mus musculus	125-130
20817126-3	2011	The results demonstrate that Zn(2+) or Al(3+) cations bring about a dramatic increase of alpha-synuclein interactions in unfavorable conditions for alpha-synuclein misfolding (neutral pH).	Zinc	29-31	synuclein alpha	Homo sapiens	89-104
20817126-3	2011	The results demonstrate that Zn(2+) or Al(3+) cations bring about a dramatic increase of alpha-synuclein interactions in unfavorable conditions for alpha-synuclein misfolding (neutral pH).	Zinc	29-31	synuclein alpha	Homo sapiens	148-163
21242634-1	2011	Metal ion (Ag(+), Cd(2+), Zn(2+)) modified CdS quantum dots (QDs) were synthesized and used for Cu(2+) sensing.	Zinc	26-32	CDP-diacylglycerol synthase 1	Homo sapiens	43-46
21242634-3	2011	Different metal ion (Ag(+), Cd(2+), Zn(2+)) modified CdS QDs also showed different analytical characteristics for Cu(2+) sensing.	Zinc	36-42	CDP-diacylglycerol synthase 1	Homo sapiens	53-56
21389614-2	2011	We found novel roles of RPT2a and RPT5a in Zn deficiency-tolerance.	Zinc	43-45	regulatory particle AAA-ATPase 2A	Arabidopsis thaliana	24-29
21389614-3	2011	Arabidopsis thaliana mutants carrying T-DNA in RPT2a and RPT5a were more sensitive to Zn deficiency than the wild-type.	Zinc	86-88	Phototropic-responsive NPH3 family protein	Arabidopsis thaliana	47-51
20812023-6	2011	The potency and specificity of Zn(2+) in activating GPR39 suggest it to be a physiologically important agonist.	Zinc	31-37	G protein-coupled receptor 39	Homo sapiens	52-57
21695274-3	2011	Arabidopsis SAP10 showed differential regulation by various abiotic stresses such as heavy metals and metalloids (Ni, Cd, Mn, Zn, and As), high and low temperatures, cold, and ABA.	Zinc	126-128	stress-associated protein 10	Arabidopsis thaliana	12-17
21695274-4	2011	Overexpression of AtSAP10 in Arabidopsis conferred strong tolerance to heavy metals such as Ni, Mn, and Zn and to high temperature stress.	Zinc	104-106	stress-associated protein 10	Arabidopsis thaliana	18-25
29381217-2	2018	The aim of the present study on hydroponically grown barley (Hordeum vulgare) was to test whether any reduction in root hydraulic conductivity (Lp) in response to Zn treatment is accompanied by a reduction in cell Lp and gene expression level of aquaporin (AQP) isoforms.	Zinc	163-165	HvPIP2;3	Hordeum vulgare	257-260
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	39-43	DNA methyltransferase 1	Rattus norvegicus	208-213
20858712-7	2010	FluoZin-3 fluorescence illustrated increased lysosomal accumulation of Zn in cells expressing SNP1 concomitant with the abrogation of Zn secretion.	Zinc	71-73	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	94-98
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	112-116	DNA methyltransferase 1	Rattus norvegicus	208-213
30058805-7	2018	Complex 6 is accessed via Zn reduction of Ru2(dsichp)4Cl (4-Cl), which along with Ru2(dsichp)4N3 (4-N3), show similar structural and electronic properties to their non-TMS-substituted analogues, 1-Cl and 1-N3.	Zinc	26-28	doublecortin domain containing 2	Homo sapiens	42-56
20615447-5	2010	Among them are the attenuating Zn(2+) ions, active site-directed proteinaceous inhibitors, such as serpins and the Kazal-type inhibitors, or the huge, unspecific compartment forming alpha(2)-macroglobulin.	Zinc	31-37	alpha-2-macroglobulin	Homo sapiens	182-204
30058805-7	2018	Complex 6 is accessed via Zn reduction of Ru2(dsichp)4Cl (4-Cl), which along with Ru2(dsichp)4N3 (4-N3), show similar structural and electronic properties to their non-TMS-substituted analogues, 1-Cl and 1-N3.	Zinc	26-28	doublecortin domain containing 2	Homo sapiens	82-96
20709757-5	2010	Like the Ca(2+)/H(+) antiporter activity catalyzed by Vcx1p, the K(+)/H(+) antiporter activity was strongly inhibited by Cd(2+) and to a lesser extend by Zn(2+).	Zinc	154-156	Vcx1p	Saccharomyces cerevisiae S288C	54-59
30028452-0	2018	Organophosphoric acid-derived CoP quantum dots@S,N-codoped graphite carbon as a trifunctional electrocatalyst for overall water splitting and Zn-air batteries.	Zinc	142-144	caspase recruitment domain family member 16	Homo sapiens	30-33
20858932-2	2010	Single-crystalline ZnS and ZnS:Te NWs were grown directly on a MGF without a catalyst, and exhibited blue-green and blue emission peaks of ~ 503 and ~ 440 nm.	Zinc	19-22	signal transducer and activator of transcription 5A	Homo sapiens	63-66
20858932-2	2010	Single-crystalline ZnS and ZnS:Te NWs were grown directly on a MGF without a catalyst, and exhibited blue-green and blue emission peaks of ~ 503 and ~ 440 nm.	Zinc	27-30	signal transducer and activator of transcription 5A	Homo sapiens	63-66
30028452-3	2018	Benefiting from the strong coupling and synergistic effect between CoP QDs and highly conductive S,N-codoped carbon, well-structured porosity and high specific surface area, the resulting CoP@SNC exhibits excellent activities for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and oxygen reduction reaction (ORR), making it a trifunctional electro-catalyst for overall water splitting and rechargeable Zn-air batteries.	Zinc	423-425	caspase recruitment domain family member 16	Homo sapiens	188-191
20876732-4	2010	Ebf1 contacts the DNA with two loop-based modules and a unique Zn coordination motif whereby each Ebf1 monomer interacts with both palindromic half-sites.	Zinc	63-65	EBF transcription factor 1	Homo sapiens	0-4
20876732-4	2010	Ebf1 contacts the DNA with two loop-based modules and a unique Zn coordination motif whereby each Ebf1 monomer interacts with both palindromic half-sites.	Zinc	63-65	EBF transcription factor 1	Homo sapiens	98-102
30028452-4	2018	When CoP@SNC is used for overall water splitting, a cell voltage as low as 1.64 V is required to reach the current density of 10 mA cm-2; the obtained rechargeable Zn-air battery with CoP@SNC as the air cathode exhibits a high open-circuit voltage of 1.45 V, a very low discharge-charge voltage gap (0.83 V at 10 mA cm-2), and a long cycle life (up to 180 cycles).	Zinc	164-166	caspase recruitment domain family member 16	Homo sapiens	5-8
30028452-4	2018	When CoP@SNC is used for overall water splitting, a cell voltage as low as 1.64 V is required to reach the current density of 10 mA cm-2; the obtained rechargeable Zn-air battery with CoP@SNC as the air cathode exhibits a high open-circuit voltage of 1.45 V, a very low discharge-charge voltage gap (0.83 V at 10 mA cm-2), and a long cycle life (up to 180 cycles).	Zinc	164-166	caspase recruitment domain family member 16	Homo sapiens	184-187
28620816-1	2018	Historical mining activities in the village of Kank (in the northern part of the Kutna Hora ore district, Czech Republic) produced large amounts of mine wastes which contain significant amounts of metal(loid) contaminants such as As, Cu, Pb, and Zn.	Zinc	246-248	KN motif and ankyrin repeat domains 1	Homo sapiens	47-51
20492471-8	2010	Immunoblots for FXa and functional assays showed that Zn2(+) -containing PS inhibited primarily the quantity of FXa formed by tissue factor (TF)-FVIIa, rather than FXa amidolytic activity.	Zinc	54-60	coagulation factor III, tissue factor	Homo sapiens	126-139
20492471-8	2010	Immunoblots for FXa and functional assays showed that Zn2(+) -containing PS inhibited primarily the quantity of FXa formed by tissue factor (TF)-FVIIa, rather than FXa amidolytic activity.	Zinc	54-60	coagulation factor III, tissue factor	Homo sapiens	141-143
20492471-9	2010	Zn2(+) -containing PS, but not Zn2(+) -deficient PS, bound to TF with high affinity (K(dapp) = 41 nm) and targeted TF function.	Zinc	0-6	coagulation factor III, tissue factor	Homo sapiens	62-64
29771714-18	2018	CONCLUSIONS: Rem maintains Zn homeostasis at reperfusion by inhibiting MTF1 and ZnT1 expression, leading to the attenuation of ER stress and cardiac injury.	Zinc	27-29	solute carrier family 30 member 1	Rattus norvegicus	80-84
20492471-9	2010	Zn2(+) -containing PS, but not Zn2(+) -deficient PS, bound to TF with high affinity (K(dapp) = 41 nm) and targeted TF function.	Zinc	0-6	coagulation factor III, tissue factor	Homo sapiens	115-117
29685974-5	2018	Crystallographic analysis revealed a unique mode of action, in which NPD11033 creates a hydrophobic cavity behind the substrate-binding pocket after a conformational change of the Zn-binding small domain of SIRT2.	Zinc	180-182	sirtuin 2	Homo sapiens	207-212
28842860-19	2018	OPG and OPG/RANKL ratios were significantly higher in the OVX-Gen and OVX-Zn groups than that in the OVX group (P &lt; 0.05).	Zinc	74-76	TNF receptor superfamily member 11B	Rattus norvegicus	0-3
28842860-19	2018	OPG and OPG/RANKL ratios were significantly higher in the OVX-Gen and OVX-Zn groups than that in the OVX group (P &lt; 0.05).	Zinc	74-76	TNF receptor superfamily member 11B	Rattus norvegicus	8-11
29802348-3	2018	The Zn2+-sensing G-protein coupled receptor, ZnR/GPR39, triggers signaling leading to cell growth, but a role for this receptor in breast cancer in unknown.	Zinc	4-8	G protein-coupled receptor 39	Homo sapiens	49-54
29802348-4	2018	Using fluorescence imaging, we found Zn2+-dependent Ca2+ release, mediated by ZnR/GPR39 activity, in TAMR tamoxifen-resistant cells derived from MCF-7 cells, but not in ER-expressing MCF-7 or T47D cells.	Zinc	37-41	G protein-coupled receptor 39	Homo sapiens	82-87
29351417-3	2018	Here, we hypothesize that the Zn2+-sensing receptor ZnR/G protein-coupled receptor 39 (GPR39), found in tissues where dynamic Zn2+ homeostasis takes place, enables extracellular Zn2+ to trigger intracellular signaling pathways regulating key cell functions in vascular cells.	Zinc	30-34	G protein-coupled receptor 39	Homo sapiens	52-85
20679226-3	2010	Preventing the coordination of Zn(2+) ions by amino acid substitutions in PEX10, PEX2, and PEX12 and overexpressing the resulting conditional sublethal mutations in WT uncovered additional functions of PEX10.	Zinc	31-33	peroxin 10	Arabidopsis thaliana	74-79
20679226-3	2010	Preventing the coordination of Zn(2+) ions by amino acid substitutions in PEX10, PEX2, and PEX12 and overexpressing the resulting conditional sublethal mutations in WT uncovered additional functions of PEX10.	Zinc	31-33	peroxin-12	Arabidopsis thaliana	91-96
20679226-3	2010	Preventing the coordination of Zn(2+) ions by amino acid substitutions in PEX10, PEX2, and PEX12 and overexpressing the resulting conditional sublethal mutations in WT uncovered additional functions of PEX10.	Zinc	31-33	peroxin 10	Arabidopsis thaliana	202-207
20553223-6	2010	Zn and/or PQ exposure increased gene expression of DAT, CYP2E1, GSTA4-4, MT-I and MT-II, but reduced the expression of VMAT-2.	Zinc	0-2	glutathione S-transferase alpha 4	Rattus norvegicus	64-71
20416985-2	2010	Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of gbnp have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic moment, spectral (IR, (1)H NMR, electronic and FAB mass) and thermal studies.	Zinc	54-62	FA complementation group B	Homo sapiens	229-232
20648354-0	2010	Zn-doped nanocrystalline TiO2 films for CdS quantum dot sensitized solar cells.	Zinc	0-2	CDP-diacylglycerol synthase 1	Homo sapiens	40-43
29351417-3	2018	Here, we hypothesize that the Zn2+-sensing receptor ZnR/G protein-coupled receptor 39 (GPR39), found in tissues where dynamic Zn2+ homeostasis takes place, enables extracellular Zn2+ to trigger intracellular signaling pathways regulating key cell functions in vascular cells.	Zinc	30-34	G protein-coupled receptor 39	Homo sapiens	87-92
29351417-3	2018	Here, we hypothesize that the Zn2+-sensing receptor ZnR/G protein-coupled receptor 39 (GPR39), found in tissues where dynamic Zn2+ homeostasis takes place, enables extracellular Zn2+ to trigger intracellular signaling pathways regulating key cell functions in vascular cells.	Zinc	126-130	G protein-coupled receptor 39	Homo sapiens	52-85
29351417-3	2018	Here, we hypothesize that the Zn2+-sensing receptor ZnR/G protein-coupled receptor 39 (GPR39), found in tissues where dynamic Zn2+ homeostasis takes place, enables extracellular Zn2+ to trigger intracellular signaling pathways regulating key cell functions in vascular cells.	Zinc	126-130	G protein-coupled receptor 39	Homo sapiens	87-92
29351417-5	2018	Knockdown of GPR39 through siRNA largely abolished Zn2+-triggered cellular activity changes, Ca2+ responses, as well as the downstream activation of Galphaq-PLC pathways.	Zinc	51-55	G protein-coupled receptor 39	Homo sapiens	13-18
29339274-6	2018	Principal Component Analysis (PCA) of the trace metal data extracted V, Cr, Cu, Zn, Pb, U and Th in the first component PC1.	Zinc	80-82	polycystin 1, transient receptor potential channel interacting	Homo sapiens	120-123
28455702-2	2018	Recently, we described zinc non-competitive interactions toward agonist binding at serotonin 5-HT1A receptors, in which biphasic effects, involving potentiation at sub-micromolar concentrations (10 muM) and inhibition at sub-millimolar concentrations (500 muM) of Zn2+ in radioligand binding assays, were consistent with both the agonist and antagonist-like effects of zinc ions observed in in vivo studies.	Zinc	264-268	5-hydroxytryptamine receptor 1A	Homo sapiens	93-99
29448650-1	2018	We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work.	Zinc	74-82	proprotein convertase subtilisin/kexin type 1	Homo sapiens	139-142
29448650-1	2018	We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work.	Zinc	74-82	chromobox 4	Homo sapiens	144-147
29448650-1	2018	We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work.	Zinc	74-82	proprotein convertase subtilisin/kexin type 1	Homo sapiens	149-152
28034013-5	2018	We have shown that the enzyme possesses glyoxalase I activity in the presence of Zn2+, Mg2+, Ni2+, and Co2+, in this order of preference.	Zinc	81-85	glyoxalase I	Homo sapiens	40-52
29337306-5	2018	Here, we have shown that Slc39a8 is expressed by endothelial cells in the developing mouse heart, where it serves to maintain cellular Zn levels.	Zinc	135-137	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	25-32
29337306-7	2018	Consistent with the in vivo observations, knockdown of SLC39A8 in HUVECs decreased ADAMTS1 transcription by decreasing cellular Zn uptake and, as a result, MTF1 transcriptional activity.	Zinc	128-130	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	55-62
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	solute carrier family 39 member 1	Homo sapiens	93-97
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	16-20	solute carrier family 39 member 1	Homo sapiens	167-171
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	solute carrier family 39 member 1	Homo sapiens	93-97
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	solute carrier family 39 member 1	Homo sapiens	167-171
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	solute carrier family 39 member 1	Homo sapiens	93-97
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Zinc	64-68	solute carrier family 39 member 1	Homo sapiens	167-171
28818764-6	2018	The ratiometric displacement of Cd2+ ions by Zn2+ ions shows an excellent selectivity towards in-situ detection of Zn2+ ions.	Zinc	45-49	CD2 molecule	Homo sapiens	32-35
28818764-6	2018	The ratiometric displacement of Cd2+ ions by Zn2+ ions shows an excellent selectivity towards in-situ detection of Zn2+ ions.	Zinc	115-119	CD2 molecule	Homo sapiens	32-35
28915474-5	2017	The interaction of heavy metal ions showed that the increase of initial Zn2+ concentration adversely affects on Cd2+ removal.	Zinc	72-76	CD2 molecule	Homo sapiens	112-115
29192165-3	2017	In cells, at non-inhibitory elevated concentrations, Zur and ZntR, only respond to Zn(II), RcnR to cobalt and FrmR to formaldehyde.	Zinc	61-63	Transcriptional repressor rcnR	Salmonella enterica subsp. enterica serovar Typhimurium	91-95
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	interleukin 10	Gallus gallus	165-170
20545365-10	2010	Additionally, although HDAC8 binds Zn(2+) nearly 10(6)-fold more tightly than Fe(2+), the affinities for both metal ions are comparable to the readily exchangeable metal concentrations estimated in living cells, suggesting that HDAC8 could bind either or both Fe(2+) or Zn(2+) in vivo.	Zinc	35-41	histone deacetylase 8	Homo sapiens	23-28
29053870-4	2017	Compared to the birds injected with PBS, LPS injection upregulated cathelicidin and IL-1 relative mRNA amounts in monocytes from birds fed 100 mg Zn+90 mg Mn, both in sulfate and OHCl form, and in birds fed 50 mg ZnOHCl+45 mg MnOHCl, but not in the birds fed 50 mg ZnSO4+45 mg MnSO4.	Zinc	146-148	interleukin 1 alpha	Homo sapiens	84-88
20545365-10	2010	Additionally, although HDAC8 binds Zn(2+) nearly 10(6)-fold more tightly than Fe(2+), the affinities for both metal ions are comparable to the readily exchangeable metal concentrations estimated in living cells, suggesting that HDAC8 could bind either or both Fe(2+) or Zn(2+) in vivo.	Zinc	35-41	histone deacetylase 8	Homo sapiens	228-233
20545365-10	2010	Additionally, although HDAC8 binds Zn(2+) nearly 10(6)-fold more tightly than Fe(2+), the affinities for both metal ions are comparable to the readily exchangeable metal concentrations estimated in living cells, suggesting that HDAC8 could bind either or both Fe(2+) or Zn(2+) in vivo.	Zinc	35-37	histone deacetylase 8	Homo sapiens	23-28
28770438-6	2017	Interestingly, administration of low doses of Zn to HFD-induced obese mice prominently ameliorated HFD-induced changes in neurogenic, synaptic plasticity markers and BDNF levels as well as lipid peroxidation in the hippocampus.	Zinc	46-48	brain derived neurotrophic factor	Mus musculus	166-170
20303360-3	2010	The aim of this study was to investigate the association between the -5 A/G metallothionein 2A (MT2A) single nucleotide polymorphism (SNP) and Cd, Zn and Cu levels in the renal cortex from autopsy cases.	Zinc	147-149	metallothionein 2A	Homo sapiens	76-94
20303360-3	2010	The aim of this study was to investigate the association between the -5 A/G metallothionein 2A (MT2A) single nucleotide polymorphism (SNP) and Cd, Zn and Cu levels in the renal cortex from autopsy cases.	Zinc	147-149	metallothionein 2A	Homo sapiens	96-100
20371992-8	2010	Zn(II) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges.	Zinc	0-2	microtubule associated protein tau	Homo sapiens	22-25
19768661-6	2010	Here we report that free Zn(2+) disrupts cellular redox status through inhibition of glutathione reductase, and induces apoptosis by redox-mediated inhibition of the mitochondrial adenine nucleotide transporter (ANT).	Zinc	25-27	solute carrier family 25 member 6	Homo sapiens	180-210
19768661-6	2010	Here we report that free Zn(2+) disrupts cellular redox status through inhibition of glutathione reductase, and induces apoptosis by redox-mediated inhibition of the mitochondrial adenine nucleotide transporter (ANT).	Zinc	25-27	solute carrier family 25 member 6	Homo sapiens	212-215
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	53-55	caspase 9	Homo sapiens	307-316
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	caspase 9	Homo sapiens	307-316
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	caspase 9	Homo sapiens	307-316
19326061-5	2009	It was observed that effects of treatment with EGCG, Zn(2+), or EGCG + Zn(2+)on mitochondria showed EGCG + Zn(2+) &gt; Zn(2+) &gt; EGCG, including cytochrome C release from the intermembrane space into the cytosol, inhibited the synthesis of ATP, loss of mitochondrial membrane potential, and activation of caspase-9.	Zinc	71-73	caspase 9	Homo sapiens	307-316
28770438-7	2017	In contrast, high-dose Zn supplementation in HFD-fed mice exacerbated the reduction of markers for neurogenesis and synaptic plasticity as well as BDNF levels, but not 4-HNE levels, in the hippocampus.	Zinc	23-25	brain derived neurotrophic factor	Mus musculus	147-151
28770438-8	2017	These results suggest that low-dose Zn supplementation in obese mice could reverse the HFD-induced reduction in neurogenic and synaptic marker proteins in the hippocampus by reducing lipid peroxidation and improving BDNF expression, while high-dose Zn supplementation exacerbates the reduction of neurogenesis by affecting synaptic markers and BDNF levels in the hippocampus.	Zinc	36-38	brain derived neurotrophic factor	Mus musculus	216-220
28770438-8	2017	These results suggest that low-dose Zn supplementation in obese mice could reverse the HFD-induced reduction in neurogenic and synaptic marker proteins in the hippocampus by reducing lipid peroxidation and improving BDNF expression, while high-dose Zn supplementation exacerbates the reduction of neurogenesis by affecting synaptic markers and BDNF levels in the hippocampus.	Zinc	36-38	brain derived neurotrophic factor	Mus musculus	344-348
29068406-9	2017	Complexing of P2.2 with Zn(II) or Cu(II) altered several of its PDT-relevant properties.	Zinc	24-30	prohibitin 2	Homo sapiens	14-18
19651194-5	2009	There were reticulocytosis and extra-medullary erythropoiesis in the spleen and an increase in serum EPO concentrations in rats fed with the high Zn diet vs. those on the standard diet.	Zinc	146-148	erythropoietin	Rattus norvegicus	101-104
19848120-6	2009	The CAS allows usto distinguish three groups of cations: (a) Al, H, Pb, Hg, and Cr, which are preferentially bound to the phenolic sites of the fulvic ligand; (b) Ca, Mg, Cd, Fe(II), and Mn, which display a greater effective affinity for carboxylic sites, in contrast to what would be expected from their individual complexation parameters; and (c) Fe(III), Cu, Zn, and Ni, for which phenolic and carboxylic distributions are overlapped.	Zinc	362-364	BCAR1 scaffold protein, Cas family member	Homo sapiens	4-7
19345008-5	2009	It was observed that the four lignite samples were considerably effective in removing Pb, Cd, Zn, and Cu ions from aqueous solutions, with the sample MT2 being the most effective.	Zinc	94-96	metallothionein 2A	Homo sapiens	150-153
19267955-9	2009	The results indicate that Zn supplementation decreased faecal scores and the reduction was accompanied by reduced intestinal permeability, which was evident from the reduced urinary lactulose:mannitol ratios and increased expression of occludin and ZO-1.	Zinc	26-28	occludin	Sus scrofa	236-244
19267955-9	2009	The results indicate that Zn supplementation decreased faecal scores and the reduction was accompanied by reduced intestinal permeability, which was evident from the reduced urinary lactulose:mannitol ratios and increased expression of occludin and ZO-1.	Zinc	26-28	zonula occludens 1	Sus scrofa	249-253
19490425-6	2009	Zn treatment dramatically increased the expression of the metallothionein (Mt), and modestly increased the expression of acute-phase protein genes (ceruloplasmin, Stat3, egr1, Cxc chemokines and heat-shock proteins).	Zinc	0-2	signal transducer and activator of transcription 3	Rattus norvegicus	163-168
19409415-5	2009	The maximum adsorption capacity of CMCS-g-D-GA for Ni2+, Zn2+ and Cu2+ was found to be 57, 56.4 and 70.2 mg/g, respectively.	Zinc	57-61	G protein signaling modulator 2	Homo sapiens	35-39
19500590-1	2009	The recombination-activating protein, RAG1, a key component of the V(D)J recombinase, binds multiple Zn(2+) ions in its catalytically required core region.	Zinc	101-103	recombination activating 1	Homo sapiens	38-42
19500590-3	2009	To address this issue, we determined the stoichiometry of Zn(2+) ions bound to the catalytically active core region of RAG1 under various conditions.	Zinc	58-60	recombination activating 1	Homo sapiens	119-123
19500590-4	2009	Using metal quantitation methods, we determined that core RAG1 can bind up to four Zn(2+) ions.	Zinc	83-85	recombination activating 1	Homo sapiens	58-62
19500590-8	2009	Significantly, the C-terminal domain in core RAG1 binds at least two Zn(2+) ions, with one zinc-binding site containing C902 and C907 as ligands (termed the CC zinc site) and H937 and H942 coordinating a Zn(2+) ion in a separate site (HH zinc site).	Zinc	69-71	recombination activating 1	Homo sapiens	45-49
19500590-8	2009	Significantly, the C-terminal domain in core RAG1 binds at least two Zn(2+) ions, with one zinc-binding site containing C902 and C907 as ligands (termed the CC zinc site) and H937 and H942 coordinating a Zn(2+) ion in a separate site (HH zinc site).	Zinc	204-206	recombination activating 1	Homo sapiens	45-49
19522520-9	2009	Finally, CCSD(T) calculations, slightly modifying MP2 insights, found that all three complexes present the same metal binding energy order, and notably Cu(2+) &gt; Ni(2+) &gt; Zn(2+) &gt; Co(2+) &gt; Fe(2+) &gt; Mn(2+).	Zinc	176-178	tryptase pseudogene 1	Homo sapiens	50-53
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Zinc	133-135	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	25-30
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Zinc	133-135	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	57-60
19499941-4	2009	The tris(phosphinoamine) Co(I) complex (Ph(2)PNH(i)Pr)(3)CoI (8) can only be generated in the presence of an added reductant such as Zn(0), indicating that the reduction of Co(II) to Co(I) only occurs in the presence of Zr in the formation of complexes 4-6.	Zinc	133-135	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	183-188
19473687-2	2009	A CAT gene from Brassica juncea was cloned and up-regulated in response to Cd/Zn.	Zinc	78-80	catalase isozyme 1	Nicotiana tabacum	2-5
19798981-3	2009	In the present paper, the direct interaction between heme-iron of myoglobin and additional metal ions [Cu (II), Zn (II) and Co( II)] was studied by UV-Vis spectra.	Zinc	112-119	myoglobin	Homo sapiens	66-75
19366695-4	2009	Expression of ZnT5 was followed by both accelerated removal of Zn2+ from the cytoplasm and its increased vesicular sequestration.	Zinc	63-67	solute carrier family 30 member 5	Homo sapiens	14-18
19240037-4	2009	Here, we demonstrate that plasmin can cleave the native NR2A amino-terminal domain (NR2A(ATD)), removing the functional high affinity Zn(2+) binding site.	Zinc	134-136	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	84-88
19240037-7	2009	Recombinant expression of NR2A with an amino-terminal deletion at Lys(317) is functional and Zn(2+) insensitive.	Zinc	93-95	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	26-30
19240037-8	2009	Whole cell voltage-clamp recordings show that Zn(2+) inhibition of agonist-evoked NMDA receptor currents of NR1/NR2A-transfected HEK 293 cells and cultured cortical neurons is significantly reduced by plasmin treatment.	Zinc	46-48	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	108-111
19240037-8	2009	Whole cell voltage-clamp recordings show that Zn(2+) inhibition of agonist-evoked NMDA receptor currents of NR1/NR2A-transfected HEK 293 cells and cultured cortical neurons is significantly reduced by plasmin treatment.	Zinc	46-48	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	112-116
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Zinc	95-97	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	47-51
19245740-3	2009	The Zn transporter ZnT5 may play a key role in the absorption of dietary Zn.	Zinc	4-6	solute carrier family 30 member 5	Homo sapiens	19-23
19245740-10	2009	This premise is being investigated by analysis of additional samples from a human adult cohort to test the hypothesis that methylation of the SLC30A5 promoter region contributes to the age-related decline in Zn status.	Zinc	208-210	solute carrier family 30 member 5	Homo sapiens	142-149
19402754-4	2009	We also show that S100A9 in the presence of Zn++ and Ca++ is an efficient ligand of receptor for advanced glycation end products (RAGE) and also an endogenous Toll ligand in that it shows a highly specific interaction with TLR4/MD2.	Zinc	44-48	toll like receptor 4	Homo sapiens	223-227
19220871-2	2009	In this work we describe the results of functional analysis of a single Kluyveromyces lactis homolog of the PDR1 gene, which encodes a zinc finger Zn(2)Cys(6)-containing transcription factor.	Zinc	147-149	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	108-112
18984033-9	2009	It is likely that Zn(2+) taken up during LTP induction potentiates CA1 LTP via NMDA receptor activation.	Zinc	18-24	carbonic anhydrase 1	Rattus norvegicus	67-70
28935959-5	2017	A novel conserved Zn2+-binding motif present in the N-terminal domain of NDCBE is identified and characterized in vitro.	Zinc	18-22	solute carrier family 4 member 8	Homo sapiens	73-78
28762409-3	2017	Here, a facile organic-free synthesis route for new zincoaluminosilicate zeolites having MOR topology, in which both Zn and Al are substituted in the framework, is demonstrated for the first time.	Zinc	117-119	opioid receptor mu 1	Homo sapiens	89-92
28685578-7	2017	The best diode properties after the aging process (SV = 3.9 x 107, eta = 1.12, and phiB,eff = 1.31 eV) were also observed for 0.63 Zn/(Zn + Sn).	Zinc	131-133	secreted phosphoprotein 1	Homo sapiens	67-74
28685578-7	2017	The best diode properties after the aging process (SV = 3.9 x 107, eta = 1.12, and phiB,eff = 1.31 eV) were also observed for 0.63 Zn/(Zn + Sn).	Zinc	135-137	secreted phosphoprotein 1	Homo sapiens	67-74
28677078-11	2017	In addition, BSA does not inhibit the binding of apo-Tf with Zn, suggesting that BSA has lower affinity to Zn than that of apo-Tf.	Zinc	107-109	albumin	Bos taurus	81-84
28380662-0	2017	Involvement of intracellular Zn2+ signaling in LTP at perforant pathway-CA1 pyramidal cell synapse.	Zinc	29-33	carbonic anhydrase 1	Rattus norvegicus	72-75
28380662-1	2017	Physiological significance of synaptic Zn2+ signaling was examined at perforant pathway-CA1 pyramidal cell synapses.	Zinc	39-43	carbonic anhydrase 1	Rattus norvegicus	88-91
28380662-4	2017	Even in rat brain slices bathed in CaEDTA in ACSF, intracellular Zn2+ level, which was measured with intracellular ZnAF-2, was increased in the stratum lacunosum-moleculare where perforant pathway-CA1 pyramidal cell synapses were contained after tetanic stimulation.	Zinc	65-69	carbonic anhydrase 1	Rattus norvegicus	197-200
28380662-5	2017	These results suggest that intracellular Zn2+ signaling, which originates in internal stores/proteins, is involved in LTP at perforant pathway-CA1 pyramidal cell synapses.	Zinc	41-45	carbonic anhydrase 1	Rattus norvegicus	143-146
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	36-40	carbonic anhydrase 1	Rattus norvegicus	131-134
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	36-40	carbonic anhydrase 1	Rattus norvegicus	238-241
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	75-79	carbonic anhydrase 1	Rattus norvegicus	131-134
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	75-79	carbonic anhydrase 1	Rattus norvegicus	238-241
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	75-79	carbonic anhydrase 1	Rattus norvegicus	131-134
28380662-6	2017	Because the influx of extracellular Zn2+ , which originates in presynaptic Zn2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.	Zinc	75-79	carbonic anhydrase 1	Rattus norvegicus	238-241
28435068-5	2017	Previous researches have shown that Drosophila MtnB responds to copper (Cu), cadmium (Cd) and zinc (Zn).	Zinc	100-102	Metallothionein B	Drosophila melanogaster	47-51
28587098-6	2017	MT2 was highly upregulated by Zn2+ in both cell cultures, while MT3 was not affected, and no other metal had an effect on either MT2 or MT3.	Zinc	30-34	metallothionein 2A	Homo sapiens	0-3
19099413-8	2009	Replacement of ZnS-coated CdSe with ZnS-coated InGaP nanoparticles provided similar biosensors (100 pM limit of detection; K(A1) = 1 x 10(9) M(-1); K(A2) = 1 x 10(7) M(-1)) but with excitation/emission wavelengths longer than the major absorbance of red blood cell hemoglobin (&gt;620 nm).	Zinc	36-39	regenerating family member 3 alpha	Homo sapiens	47-52
28263766-2	2017	In 1995, the SHH crystal structure predicted that SHH-E176 (human)/E177 (mouse) regulates signaling through a Zn2+-dependent mechanism.	Zinc	110-114	sonic hedgehog signaling molecule	Homo sapiens	13-16
28263766-2	2017	In 1995, the SHH crystal structure predicted that SHH-E176 (human)/E177 (mouse) regulates signaling through a Zn2+-dependent mechanism.	Zinc	110-114	sonic hedgehog	Mus musculus	50-53
28263766-3	2017	While Zn2+ is known to be required for SHH protein stability, a regulatory role for SHH-E176 or Zn2+ has not been described.	Zinc	6-10	sonic hedgehog	Mus musculus	39-42
28263766-4	2017	Here, we show that SHH-E176/177 modulates Zn2+-dependent cross-linking in vitro and is required for endogenous signaling, in vivo.	Zinc	42-46	sonic hedgehog	Mus musculus	19-22
28263766-8	2017	Together, these results reveal a novel role for E177-Zn2+ in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.	Zinc	53-57	sonic hedgehog	Mus musculus	72-75
18981218-7	2009	Combining all of the data, we suggest a structural model where chromosomal DNA is bound at the Zn-domain and cleaved at the DEDDh nuclease domain in CRN-4 when the cell is undergoing apoptosis.	Zinc	95-97	Cell death-related nuclease 4	Caenorhabditis elegans	149-154
28134465-1	2017	A new kind of multitetrahedron sheath ternary ZnS-(CdS/Au) hetero-nanorod is prepared, in which one 1D ultrathin ZnS nanorod is integrated with segmented tetrahedron sheaths made of CdS, and more importantly, Au nanoparticles can be decorated in a targeted manner onto the vertexes and edges of CdS tetrahedron sheaths solely, for achieving performance improvement in photoelectric and photochemical conversion applications.	Zinc	46-49	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
18714988-2	2008	This strategy is successful in the preparation of six mixed-metal MCPs, where Co/Zn and Ni/Zn versions of MOF-4, MOF-39, and a Zn-BTEC MCP are reported.	Zinc	81-83	capping actin protein, gelsolin like	Homo sapiens	66-69
18714988-2	2008	This strategy is successful in the preparation of six mixed-metal MCPs, where Co/Zn and Ni/Zn versions of MOF-4, MOF-39, and a Zn-BTEC MCP are reported.	Zinc	91-93	capping actin protein, gelsolin like	Homo sapiens	66-69
28134465-1	2017	A new kind of multitetrahedron sheath ternary ZnS-(CdS/Au) hetero-nanorod is prepared, in which one 1D ultrathin ZnS nanorod is integrated with segmented tetrahedron sheaths made of CdS, and more importantly, Au nanoparticles can be decorated in a targeted manner onto the vertexes and edges of CdS tetrahedron sheaths solely, for achieving performance improvement in photoelectric and photochemical conversion applications.	Zinc	113-116	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
28358304-4	2017	Humans and Escherichia coli possess a single copy of GLYI (encoding either the Ni- or Zn-dependent form) and GLYII genes, which through MG detoxification provide protection against various pathological and disease conditions.	Zinc	86-88	glyoxalase I	Homo sapiens	53-57
28358304-6	2017	Plants possess both Ni2+- and Zn2+-dependent forms of GLYI, and studies on plant glyoxalases reveal the various unique features of these enzymes distinguishing them from prokaryotic and other eukaryotic glyoxalases.	Zinc	30-34	glyoxalase I	Homo sapiens	54-58
28245828-4	2017	In Saccharomyces cerevisiae, organism, which does not metabolize xylose, gene CAT8 encodes a Zn-cluster transcriptional activator necessary for expression of genes involved in gluconeogenesis, respiration, glyoxylic cycle and ethanol utilization.	Zinc	93-95	DNA-binding transcription factor CAT8	Saccharomyces cerevisiae S288C	78-82
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	65-67	carnosine dipeptidase 1	Homo sapiens	84-97
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	65-67	carnosine dipeptidase 1	Homo sapiens	99-103
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	65-67	carnosine dipeptidase 1	Homo sapiens	146-150
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	131-133	carnosine dipeptidase 1	Homo sapiens	84-97
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	131-133	carnosine dipeptidase 1	Homo sapiens	99-103
28114379-0	2017	Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.	Zinc	131-133	carnosine dipeptidase 1	Homo sapiens	146-150
28100752-7	2017	Furthermore, the recovery appeared to be accompanied by mitochondrial Zn2+ accumulation (via the mitochondrial Ca2+ uniporter MCU) in CA1 but not in CA3 neurons and was markedly diminished in MT-III knock-outs, suggesting that it depended upon Zn2+ mobilization from this protein.	Zinc	70-74	carbonic anhydrase 1	Mus musculus	134-137
28100752-7	2017	Furthermore, the recovery appeared to be accompanied by mitochondrial Zn2+ accumulation (via the mitochondrial Ca2+ uniporter MCU) in CA1 but not in CA3 neurons and was markedly diminished in MT-III knock-outs, suggesting that it depended upon Zn2+ mobilization from this protein.	Zinc	70-74	metallothionein 3	Mus musculus	192-198
28100752-7	2017	Furthermore, the recovery appeared to be accompanied by mitochondrial Zn2+ accumulation (via the mitochondrial Ca2+ uniporter MCU) in CA1 but not in CA3 neurons and was markedly diminished in MT-III knock-outs, suggesting that it depended upon Zn2+ mobilization from this protein.	Zinc	244-248	carbonic anhydrase 1	Mus musculus	134-137
28100752-7	2017	Furthermore, the recovery appeared to be accompanied by mitochondrial Zn2+ accumulation (via the mitochondrial Ca2+ uniporter MCU) in CA1 but not in CA3 neurons and was markedly diminished in MT-III knock-outs, suggesting that it depended upon Zn2+ mobilization from this protein.	Zinc	244-248	metallothionein 3	Mus musculus	192-198
28100752-10	2017	These data may be consistent with observations of prominent mitochondrial dysfunction as a critical early event in the delayed degeneration of CA1 neurons after ischemia and support a hypothesis that mitochondrial Zn2+ accumulation in the early reperfusion period may be a critical and targetable upstream event in the injury cascade.	Zinc	214-218	carbonic anhydrase 1	Mus musculus	143-146
27726077-7	2017	However, in root apoplast, decreased SOD and ascorbate peroxidase activities as well as increased POD, catalase, and GR activities were caused by different Zn, Fe, and Cu interactions.	Zinc	156-158	peroxidase-like	Triticum aestivum	98-101
27769419-2	2016	The interplay between aberrations in the structural organization and elemental composition of SN neuron bodies has recently gained in importance as selected metals: Fe, Cu, Zn, Ca were found to trigger oxidative-stress-mediated aberration in their molecular assembly due to concomitant protein (alpha-synuclein, tau-protein) aggregation, gliosis and finally oxidative stress.	Zinc	173-175	synuclein alpha	Homo sapiens	295-310
18570882-5	2008	In this study, we determined the potency of Zn(2+)-cyclen-PAGE for the detection of the Gua/Cyt-to-Cyt/Gua single substitutions in some artificial Gua/Cyt-lined sequences derived from a human cardiac sodium channel gene, SCN5A.	Zinc	44-46	sodium voltage-gated channel alpha subunit 5	Homo sapiens	221-226
18543905-1	2008	Color-tunable Zn(II) complexes of the type Zn( N,O-OPh (OxZ)ArX) 2 ( 5), where the ligand consists of an oxazolylphenolate ion connected at the 4-position by a 2,4-substituted aryl functional group with X = NMe 2 a, OMe b, Ph c, Cl d, F 2 e, and CN f, were prepared.	Zinc	14-16	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	207-212
18558110-5	2008	With a 2 min deposition time in the presence of oxygen, linear calibration curves were obtained in a wide concentration range (about 2-0.001 microM) with detection limits of 8.6 nM (0.56 microg dm(-3)) for Zn2+, 1.1 nM (0.12 microg dm(-3)) for Cd2+ and 0.37 nM (0.077 microg dm(-3)) for Pb(2+).	Zinc	206-210	CD2 molecule	Homo sapiens	244-247
18451556-0	2008	Coordination of divalent metal cation to amide group to form adduct ion in FAB mass spectrometry: implication of Zn2+ in enzymatic hydrolysis of amide bond.	Zinc	113-117	FA complementation group B	Homo sapiens	75-78
18451058-2	2008	This gene is regulated by at least two transcription factors with Zn(2)-Cys(6) finger DNA-binding motifs, Pdr1p and Pdr3p.	Zinc	66-68	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	106-111
18451058-6	2008	These genes (CTA4, ASG1 and CTF1) encode proteins with Zn(2)-Cys(6)-type zinc finger motifs in their N-terminal domains.	Zinc	55-57	DNA helicase	Saccharomyces cerevisiae S288C	28-32
18369486-1	2008	The first structurally characterized mononuclear biscarbamate complex of Zn with eta1-coordinated carbamate ligands can be prepared by reaction between [EtZn(O2CN(iBu)2)]4 and a guanidine base.	Zinc	73-75	secreted phosphoprotein 1	Homo sapiens	81-85
17590860-5	2008	It was also shown that the RWPE-1 cells respond to Zn(+2) and Cd(+2) exposure by induction of the basally expressed MT mRNAs and the accumulation of high levels MT-1/2 protein (in excess of 10% of total protein).	Zinc	51-53	metallothionein 2A	Homo sapiens	161-167
18083705-1	2008	S100A3 is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+.	Zinc	117-121	S100 calcium binding protein A3	Homo sapiens	0-6
17350247-8	2007	The Cu(II)-MIIP exhibited an imprinting efficiency of 2.0 and it was showing 8% interference from a mixture of Zn, Ni and Co ions.	Zinc	111-113	migration and invasion inhibitory protein	Homo sapiens	11-15
29035259-7	2016	Here, we present Zn and Ni isotope data for the water column and sediments of the Black Sea.	Zinc	17-19	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	88-91
27324419-4	2016	At optimal preconcentration conditions, calibration curves were linear from 1 to 150 ng mL-1 for Ni and Cu and from 1 to 200 ng mL-1 for Zn.	Zinc	137-139	L1 cell adhesion molecule	Mus musculus	128-132
17503802-5	2007	Our calculations indicate that the metal ion in Fe2+-PDF is always pentacoordinated during the reaction process, while that in Zn2+-PDF is only tetrahedrally coordinated and not bound to the substrate in the reactant complex.	Zinc	127-131	peptide deformylase, mitochondrial	Homo sapiens	132-135
17503802-6	2007	This difference in their metal coordination is suggested to account for the lower activity of Zn2+-PDF in comparison with Fe2+-PDF.	Zinc	94-98	peptide deformylase, mitochondrial	Homo sapiens	99-102
17503802-6	2007	This difference in their metal coordination is suggested to account for the lower activity of Zn2+-PDF in comparison with Fe2+-PDF.	Zinc	94-98	peptide deformylase, mitochondrial	Homo sapiens	127-130
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Zinc	130-134	transient receptor potential cation channel subfamily M member 4	Homo sapiens	52-57
17303564-0	2007	Stabilizing effect of Zn2+ in native bovine rhodopsin.	Zinc	22-26	rhodopsin	Bos taurus	44-53
17303564-2	2007	We applied SMFS to understand the effect of Zn2+ on the molecular interactions underlying the structure of rhodopsin.	Zinc	44-48	rhodopsin	Bos taurus	107-116
17303564-6	2007	Thus, Zn2+ stabilizes the structure of rhodopsin in a specific manner.	Zinc	6-10	rhodopsin	Bos taurus	39-48
17381514-8	2007	Similarly, cells expressing alpha-syn displayed increased ion current activity consistent with the formation of Zn(2+)-sensitive nonselective cation channels.	Zinc	112-118	synuclein alpha	Homo sapiens	28-37
17086401-0	2007	Expression of Arabidopsis phytochelatin synthase in Indian mustard (Brassica juncea) plants enhances tolerance for Cd and Zn.	Zinc	122-124	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	26-48
17277087-10	2007	MTP1 has been identified as a tonoplast Zn transporter and a zif1-1 mtp1-1 double mutant was more sensitive to Zn than either of the single mutants, suggesting ZIF1 influences a distinct mechanism of Zn homeostasis.	Zinc	40-42	zinc transporter	Arabidopsis thaliana	0-4
17277087-10	2007	MTP1 has been identified as a tonoplast Zn transporter and a zif1-1 mtp1-1 double mutant was more sensitive to Zn than either of the single mutants, suggesting ZIF1 influences a distinct mechanism of Zn homeostasis.	Zinc	111-113	zinc transporter	Arabidopsis thaliana	0-4
17277087-10	2007	MTP1 has been identified as a tonoplast Zn transporter and a zif1-1 mtp1-1 double mutant was more sensitive to Zn than either of the single mutants, suggesting ZIF1 influences a distinct mechanism of Zn homeostasis.	Zinc	111-113	zinc transporter	Arabidopsis thaliana	68-72
17279683-2	2007	The objective of this work was to assess the intracellular Cd2+ concentration in human breast cancer MCF-7 cells treated with cadmium telluride (CdTe) and core/shell cadmium selenide/zinc sulfide (CdSe/ZnS) nanoparticles capped with mercaptopropionic acid (MPA), cysteamine (Cys), or N-acetylcysteine (NAC) conjugated to cysteamine.	Zinc	202-205	CD2 molecule	Homo sapiens	59-62
17118402-7	2007	The Zn(2+) dissociation constant from the Lck-SH3 dimer is estimated to be lower than 100 nM.	Zinc	4-10	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
17020887-5	2006	These effects were blocked by the HO-1 inhibitors Zn- and Sn-protoporphyrin IX.	Zinc	50-52	heme oxygenase 1	Homo sapiens	34-38
16973620-5	2006	Characterization of the isolated HMA2 C terminus showed that this fragment binds three Zn2+ with high affinity (Kd = 16 +/- 3 nM).	Zinc	87-91	heavy metal atpase 2	Arabidopsis thaliana	33-37
16914250-6	2006	Entry via Zn2+, Fe2+, and Ca2+ transporters is the molecular basis of Cd2+ uptake into plant cells.	Zinc	10-14	CD2 molecule	Homo sapiens	70-73
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Zinc	210-216	histone deacetylase 8	Homo sapiens	25-46
16681389-4	2006	Here we demonstrate that histone deacetylase 8 (HDAC8) is catalytically active with a number of divalent metal ions in a 1:1 stoichiometry with the following order of specific activity: Co(II) &gt; Fe(II) &gt; Zn(II) &gt; Ni(II).	Zinc	210-216	histone deacetylase 8	Homo sapiens	48-53
16595927-1	2006	Previous studies have suggested that during forebrain ischemia, considerable Zn2+ is released from synaptic vesicles of gultamatergic neuronal terminals and accumulates in hippocampal CA1 pyramidal neurons, leading to delayed neuronal death.	Zinc	77-81	carbonic anhydrase 1	Rattus norvegicus	184-187
16595927-3	2006	In this study, we investigated the temporal change of extracellular Zn2+ in the hippocampal CA1 area using microdialysis and the accumulation of Zn2+ in hippocampal CA1 neurons with TSQ staining in rats with a transient forebrain ischemia.	Zinc	68-72	carbonic anhydrase 1	Rattus norvegicus	92-95
16595927-3	2006	In this study, we investigated the temporal change of extracellular Zn2+ in the hippocampal CA1 area using microdialysis and the accumulation of Zn2+ in hippocampal CA1 neurons with TSQ staining in rats with a transient forebrain ischemia.	Zinc	145-149	carbonic anhydrase 1	Rattus norvegicus	165-168
16595927-4	2006	The level of extracellular Zn2+ in the CA1 area increased transiently reaching a peak 15 min after occlusion, then decreased with time, returning to the basal level 15 min after reperfusion.	Zinc	27-31	carbonic anhydrase 1	Rattus norvegicus	39-42
16533897-4	2006	Previously, we demonstrated that thiol-specific reagents inhibit Kv4.1 channels by reacting in a state-dependent manner with native Zn(2+) site thiolate groups in the T1-T1 interface; therefore, we concluded that the T1-T1 interface is functionally active and not protected by Zn(2+) (Wang, G., M. Shahidullah, C.A.	Zinc	277-279	potassium voltage-gated channel subfamily D member 1	Homo sapiens	65-70
16736756-9	2006	The thermodynamic binding constant for Gd3+ to the nanoparticles was approximately 10(18) M(-1) and transmetallation studies with Zn2+ yielded kinetic constants K1 and K(-1) of 0.033 and 0.022 1/h, respectively, with an equilibrium constant of 1.5.	Zinc	130-134	GRDX	Homo sapiens	39-42
16343939-8	2006	Electrophoretic mobility shift assay with double-stranded DNA containing the double Egr1 consensus site 5"-GCG-TGG-GCG-3" confirmed that 6HIS-ZN-wt1 has higher DNA binding affinity than 6HIS-ZN+wt1.	Zinc	142-144	early growth response 1	Homo sapiens	84-88
27324419-6	2016	The obtained detection limits were 0.08 ng mL-1 for Ni and 0.09 ng mL-1 for Cu and Zn.	Zinc	83-85	L1 cell adhesion molecule	Mus musculus	67-71
27694524-6	2016	In fact, the contribution of AtPCS1 to tolerating Zn excess is comparable with that of the major Zn tolerance factor MTP1.	Zinc	97-99	zinc transporter	Arabidopsis thaliana	117-121
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	runt related transcription factor 2	Mus musculus	141-146
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	187-192
27444578-6	2016	Molecular data revealed that Zn-doped TiO2 NPs induced the down-regulation of super oxide dismutase gene while the up-regulation of heme oxygenase-1 gene in MCF-7 cells.	Zinc	29-31	heme oxygenase 1	Homo sapiens	132-148
16212555-3	2006	Expression of TrZnT-1 in a metallothionein acquiescent cell line suggested that this protein reduces intracellular Zn2+ levels.	Zinc	115-119	zinc transporter 1	Takifugu rubripes	14-21
16212555-5	2006	However, addition of N-ethylmaleimide increased TrZnT-1-mediated transport, possibly by increasing intracellular free Zn2+ levels by Zn2+ release from carrier proteins.	Zinc	118-122	zinc transporter 1	Takifugu rubripes	48-55
16212555-5	2006	However, addition of N-ethylmaleimide increased TrZnT-1-mediated transport, possibly by increasing intracellular free Zn2+ levels by Zn2+ release from carrier proteins.	Zinc	133-137	zinc transporter 1	Takifugu rubripes	48-55
27283079-2	2016	For example, CdS itself is inactive and loading of cocatalysts is indispensable to achieve high efficiency of hydrogen evolution, but the reverse is true for ZnS.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
16255717-7	2006	Differing from the activity against SM, the activity against PAF was optimal at pH 7.5, inhibited by EDTA and stimulated by 0.1-0.25 mM Zn2+.	Zinc	136-140	PCNA clamp associated factor	Homo sapiens	61-64
16380093-7	2006	Decorin interacted with mature myostatin in the presence of concentrations of Zn(2+) greater than 10microM, but not in the absence of Zn(2+).	Zinc	78-80	decorin	Homo sapiens	0-7
16266835-7	2006	Complementary studies with Cd2+ ions cause perturbations to 1H NMR spectra that are strikingly similar to that observed for Zn2+.	Zinc	124-128	CD2 molecule	Homo sapiens	27-30
16330358-9	2005	Also, metallothionein 1 genes (MT1F, MT1G, MT1K) were up-regulated by Zn only.	Zinc	70-72	metallothionein 1G	Homo sapiens	37-41
27283079-8	2016	On pure (110) with large DeltaGH*, the photocatalytic HER is favored on ZnS due to its higher CBM; on Pt loaded (110) with small DeltaGH*, the photocatalytic HER is favored on CdS due to its lower CBM.	Zinc	72-75	CDP-diacylglycerol synthase 1	Homo sapiens	176-179
16330358-9	2005	Also, metallothionein 1 genes (MT1F, MT1G, MT1K) were up-regulated by Zn only.	Zinc	70-72	metallothionein 1G	Homo sapiens	43-47
27154831-2	2016	Under excitation with near-infrared (NIR) light at 808 nm, the Mn(2+):ZnS@SiO2/MoS2-RBS nanocomposites showed the dual-emissive two-photon excited photoluminescence (TPEPL) that induced RBS photolysis to release NO in situ.	Zinc	70-73	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	84-87
16094687-7	2005	On the other hand, a trisaccharide--Man alpha(1,3)Hin beta(1,2)Man alphaMe--was bent immediately after the addition of Zn(II) or Hg(II), and the bent population reached 75%, much larger than those of all the other hinged trisaccharides ever tested (&lt;40%).	Zinc	119-121	adrenoceptor alpha 1D	Homo sapiens	40-49
27154831-2	2016	Under excitation with near-infrared (NIR) light at 808 nm, the Mn(2+):ZnS@SiO2/MoS2-RBS nanocomposites showed the dual-emissive two-photon excited photoluminescence (TPEPL) that induced RBS photolysis to release NO in situ.	Zinc	70-73	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	186-189
27147951-5	2016	Significant deficits in brain bioenergetics, Zn levels, and Shank3 protein expression were observed in the Zn-rich regions KI hippocampus and cerebellum at PND21, with some of these effects lasting into adulthood (PND210).	Zinc	107-109	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	60-66
16236145-8	2005	In the groups of Zn+Cd, Ca+Cd and Cys+Cd co-administration, AChE activity remained high (+42%; P&lt;0.001, +41%; P&lt;0.001 and +141%; P&lt;0.001 respectively), while total antioxidant status returned to the saline control levels.	Zinc	17-20	acetylcholinesterase	Rattus norvegicus	60-64
26806311-8	2016	The upper pKa reflects the ionization of the metal-bound water molecule and shifts to 9.1 in Zn(II)-HDAC8.	Zinc	93-99	histone deacetylase 8	Homo sapiens	100-105
26618301-9	2016	The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of &gt;0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb).	Zinc	224-226	heme oxygenase 1	Homo sapiens	41-46
16277363-3	2005	The radical initiator Cp2TiCl was prepared in situ from commercially available Cp2TiCl2 and Zn dust in THF under argon.	Zinc	92-94	ceruloplasmin	Homo sapiens	22-25
28174721-3	2016	We hypothesized that Zn, transported into the granule through the Zn transporter (ZnT)2, is critical for signature PC functions.	Zinc	21-23	solute carrier family 30 (zinc transporter), member 2	Mus musculus	66-87
16087241-4	2005	We show herein that NAC will form beta-pleated conformers at a peptide concentration of only 2.0 microM and that metals, and Zn(II) and Cu(II) in particular, accelerate the formation of these fibrils.	Zinc	125-127	synuclein alpha	Homo sapiens	20-23
28174721-13	2016	CONCLUSIONS: ZnT2 is critical for Zn import into PC granules, and the inability to import Zn leads to profound defects in PC function and uncoordinated granule secretion.	Zinc	34-36	solute carrier family 30 (zinc transporter), member 2	Mus musculus	13-17
26241779-5	2016	RESULTS: HIF-2alpha activated the zinc-ZIP8-MTF1 axis in chondrocytes by upregulating the Zn(2+) transporter ZIP8, thereby increasing Zn(2+) influx and activating the downstream transcription factor MTF1.	Zinc	90-92	endothelial PAS domain protein 1	Mus musculus	9-19
16076162-3	2005	The [Ru(bpy)2(tpphz)]2+ DNA light switch can be turned OFF statically in the presence of Co2+, Ni2+, and Zn2+, and the emission can be fully restored by the addition of EDTA.	Zinc	105-109	complement C2	Homo sapiens	89-92
26241779-5	2016	RESULTS: HIF-2alpha activated the zinc-ZIP8-MTF1 axis in chondrocytes by upregulating the Zn(2+) transporter ZIP8, thereby increasing Zn(2+) influx and activating the downstream transcription factor MTF1.	Zinc	90-92	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	39-43
26241779-5	2016	RESULTS: HIF-2alpha activated the zinc-ZIP8-MTF1 axis in chondrocytes by upregulating the Zn(2+) transporter ZIP8, thereby increasing Zn(2+) influx and activating the downstream transcription factor MTF1.	Zinc	90-92	metal response element binding transcription factor 1	Mus musculus	44-48
26241779-5	2016	RESULTS: HIF-2alpha activated the zinc-ZIP8-MTF1 axis in chondrocytes by upregulating the Zn(2+) transporter ZIP8, thereby increasing Zn(2+) influx and activating the downstream transcription factor MTF1.	Zinc	90-92	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	109-113
26375174-0	2015	Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.	Zinc	46-52	G protein-coupled receptor 39	Homo sapiens	87-92
16038907-0	2005	Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation.	Zinc	31-33	zinc transporter	Arabidopsis thaliana	21-25
16038907-0	2005	Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation.	Zinc	86-88	zinc transporter	Arabidopsis thaliana	21-25
26375174-1	2015	Synaptically released Zn(2+) acts as a neurotransmitter, in part, by activating the postsynaptic metabotropic Zn(2+)-sensing Gq protein-coupled receptor (mZnR/GPR39).	Zinc	22-24	G protein-coupled receptor 39	Homo sapiens	159-164
16038907-1	2005	The Arabidopsis thaliana metal tolerance protein 1 (MTP1) of the cation diffusion facilitator family of membrane transport proteins can mediate the detoxification of Zn in Arabidopsis and yeast.	Zinc	166-168	zinc transporter	Arabidopsis thaliana	25-50
26375174-1	2015	Synaptically released Zn(2+) acts as a neurotransmitter, in part, by activating the postsynaptic metabotropic Zn(2+)-sensing Gq protein-coupled receptor (mZnR/GPR39).	Zinc	110-112	G protein-coupled receptor 39	Homo sapiens	159-164
16038907-1	2005	The Arabidopsis thaliana metal tolerance protein 1 (MTP1) of the cation diffusion facilitator family of membrane transport proteins can mediate the detoxification of Zn in Arabidopsis and yeast.	Zinc	166-168	zinc transporter	Arabidopsis thaliana	52-56
26468492-12	2015	Furthermore, the ileal expression and function of hepatocyte nuclear factor 4alpha, which was impaired in the AF group, was significantly elevated in the AF/Zn group compared with the PF group.	Zinc	157-159	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	50-82
16038907-2	2005	Xenopus laevis oocytes expressing AtMTP1 accumulate more Zn than oocytes expressing the AtMTP1(D94A) mutant or water-injected oocytes.	Zinc	57-59	zinc transporter	Arabidopsis thaliana	34-40
16038907-5	2005	RNA interference-mediated silencing of AtMTP1 causes Zn hypersensitivity and a reduction in Zn concentrations in vegetative plant tissues.	Zinc	53-55	zinc transporter	Arabidopsis thaliana	39-45
16038907-5	2005	RNA interference-mediated silencing of AtMTP1 causes Zn hypersensitivity and a reduction in Zn concentrations in vegetative plant tissues.	Zinc	92-94	zinc transporter	Arabidopsis thaliana	39-45
15934064-8	2005	E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure.	Zinc	46-52	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	2-5
15934064-8	2005	E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure.	Zinc	46-52	metallothionein 1B	Homo sapiens	97-100
15934064-8	2005	E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure.	Zinc	46-52	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	108-111
26884962-8	2015	TGF-beta RI content in 200 muM Zn group was significantly decreased and the protein content of TGF-beta RII was not affected.	Zinc	31-33	transforming growth factor beta receptor 1	Homo sapiens	0-11
26884962-11	2015	Zn could significantly inhibit the expression of alphaSMA and type I collagen by inhibiting TGF-beta RI expression and promoting MMP-13 expression.	Zinc	0-2	transforming growth factor beta receptor 1	Homo sapiens	92-103
26530531-0	2015	Reactions of Hexa-aquo Transition Metal Ions with the Hydrated Electron up to 300  C. Reactions of the hydrated electron with divalent aqueous transition-metal ions, Cd(2+), Zn(2+), Ni(2+), Cu(2+), Co(2+), Fe(2+), and Mn(2+), were studied using a pulse radiolysis technique.	Zinc	174-180	hexosaminidase subunit alpha	Homo sapiens	13-17
16022539-8	2005	Cu(II) and Zn(II) complexes of 8 were synthesized in situ and studied by FAB-MS, ESI-MS, UV/vis, and EPR (for 8(Cu)), and FAB-MS, ESI-MS, and NMR (for 8(Zn)).	Zinc	11-17	FA complementation group B	Homo sapiens	73-76
16022539-8	2005	Cu(II) and Zn(II) complexes of 8 were synthesized in situ and studied by FAB-MS, ESI-MS, UV/vis, and EPR (for 8(Cu)), and FAB-MS, ESI-MS, and NMR (for 8(Zn)).	Zinc	11-17	FA complementation group B	Homo sapiens	122-125
16022539-8	2005	Cu(II) and Zn(II) complexes of 8 were synthesized in situ and studied by FAB-MS, ESI-MS, UV/vis, and EPR (for 8(Cu)), and FAB-MS, ESI-MS, and NMR (for 8(Zn)).	Zinc	11-13	FA complementation group B	Homo sapiens	73-76
16022539-8	2005	Cu(II) and Zn(II) complexes of 8 were synthesized in situ and studied by FAB-MS, ESI-MS, UV/vis, and EPR (for 8(Cu)), and FAB-MS, ESI-MS, and NMR (for 8(Zn)).	Zinc	11-13	FA complementation group B	Homo sapiens	122-125
15953358-8	2005	In contrast, the addition of 300 microM Zn to brain sections of mGlu2(-/-) mice caused large increases in binding density of 289 and 242% in DGmol and CA1-LMol, respectively.	Zinc	40-42	carbonic anhydrase 1	Mus musculus	151-154
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	23-25	metallothionein-1	Danio rerio	98-101
15917084-2	2005	Four metal ions (Mg(+2), Mn(+2), Zn(2+), and Co(2+)) activate endogenous, exogenous, and baculovirus-expressed recombinant MST3 within the physiological concentration range.	Zinc	33-39	serine/threonine kinase 24	Homo sapiens	123-127
16252197-15	2005	The Cu/Zn ratio, when compared with Zn, ceruloplasmin and Cu, showed significant results (r= 0.	Zinc	7-9	ceruloplasmin	Homo sapiens	40-53
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	23-25	heat shock protein 8-like	Danio rerio	111-116
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	180-182	metallothionein-1	Danio rerio	98-101
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	180-182	heat shock protein 8-like	Danio rerio	111-116
26306426-6	2015	Of the 797 proteins identified, expression of two members of the Zrt- and Irt-related protein family, ZIP3 and ZIP9, and three defensin-like family proteins was markedly induced in wild-type but not in the bzip19 mutant under Zn-deficient conditions.	Zinc	226-228	zinc transporter 3 precursor	Arabidopsis thaliana	102-106
15913136-4	2005	The selectivity and efficiency of Cd2+ transport from an aqueous solution containing other cations, such as Co2+, Cr3+, Ni2+, Fe2+, Mn2+, Pd2+ and Zn2+ ions, were investigated.	Zinc	147-151	CD2 molecule	Homo sapiens	34-37
26413806-5	2015	Pearson correlation and principal component analysis showed that there were significant positive correlations (p&lt;0.05) between all of the metals, and As, Cd, Cr, Mn, Ni, Pb, and Zn were closely associated with the first principal component (PC1), which explained 39.81% of the total variance.	Zinc	181-183	polycystin 1, transient receptor potential channel interacting	Homo sapiens	244-247
26204819-0	2015	Influx of extracellular Zn(2+) into the hippocampal CA1 neurons is required for cognitive performance via long-term potentiation.	Zinc	24-30	carbonic anhydrase 1	Rattus norvegicus	52-55
15753101-0	2005	A putative function for the arabidopsis Fe-Phytosiderophore transporter homolog AtYSL2 in Fe and Zn homeostasis.	Zinc	97-99	YELLOW STRIPE like 2	Arabidopsis thaliana	80-86
26204819-1	2015	Physiological significance of synaptic Zn(2+) signaling was examined in the CA1 of young rats.	Zinc	39-45	carbonic anhydrase 1	Rattus norvegicus	76-79
15753101-4	2005	Quantitative real-time polymerase chain reaction (PCR) and analysis of transgenic plants expressing an AtYSL2 promoter::beta-glucuronidase gene further allowed the detection of down-regulated AtYSL2 gene expression under Zn and Fe deficiency.	Zinc	221-223	YELLOW STRIPE like 2	Arabidopsis thaliana	103-109
26204819-3	2015	In vivo CA1 LTP was inhibited under perfusion with CaEDTA and ZnAF-2DA, extracellular and intracellular Zn(2+) chelators, respectively, suggesting that the influx of extracellular Zn(2+) is required for in vivo CA1 LTP induction.	Zinc	62-64	carbonic anhydrase 1	Rattus norvegicus	8-11
15753101-4	2005	Quantitative real-time polymerase chain reaction (PCR) and analysis of transgenic plants expressing an AtYSL2 promoter::beta-glucuronidase gene further allowed the detection of down-regulated AtYSL2 gene expression under Zn and Fe deficiency.	Zinc	221-223	YELLOW STRIPE like 2	Arabidopsis thaliana	192-198
26204819-3	2015	In vivo CA1 LTP was inhibited under perfusion with CaEDTA and ZnAF-2DA, extracellular and intracellular Zn(2+) chelators, respectively, suggesting that the influx of extracellular Zn(2+) is required for in vivo CA1 LTP induction.	Zinc	62-64	carbonic anhydrase 1	Rattus norvegicus	211-214
26204819-3	2015	In vivo CA1 LTP was inhibited under perfusion with CaEDTA and ZnAF-2DA, extracellular and intracellular Zn(2+) chelators, respectively, suggesting that the influx of extracellular Zn(2+) is required for in vivo CA1 LTP induction.	Zinc	104-106	carbonic anhydrase 1	Rattus norvegicus	8-11
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Zinc	30-36	carbonic anhydrase 1	Rattus norvegicus	83-86
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Zinc	30-36	carbonic anhydrase 1	Rattus norvegicus	133-136
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Zinc	168-174	carbonic anhydrase 1	Rattus norvegicus	83-86
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Zinc	168-174	carbonic anhydrase 1	Rattus norvegicus	133-136
26204819-6	2015	These data suggest that intracellular Zn(2+) signaling in the CA1 is required for object recognition memory via LTP.	Zinc	38-44	carbonic anhydrase 1	Rattus norvegicus	62-65
26204819-8	2015	The influx of extracellular Zn(2+) into CA1 pyramidal cells has bidirectional action in CA1 LTP.	Zinc	28-30	carbonic anhydrase 1	Rattus norvegicus	40-43
26204819-8	2015	The influx of extracellular Zn(2+) into CA1 pyramidal cells has bidirectional action in CA1 LTP.	Zinc	28-30	carbonic anhydrase 1	Rattus norvegicus	88-91
26204819-9	2015	The present study indicates that the degree of extracellular Zn(2+) influx into CA1 neurons is critical for LTP and cognitive performance.	Zinc	61-67	carbonic anhydrase 1	Rattus norvegicus	80-83
26142902-3	2015	The rLap1 was about 36.7 kDa with an optimal pH 8.0 and optimal temperature 50  C for substrate Leu-p-nitroanilide and it sustained 50 % activity after 1 h incubation at 50  C. The activity of rLap1 was significantly inhibited by EDTA, whereas Co(2+), Mn(2+), and Ca(2+) ions, but not Zn(2+) ions, restored its activity.	Zinc	285-291	alanyl aminopeptidase, membrane	Rattus norvegicus	4-9
26142902-3	2015	The rLap1 was about 36.7 kDa with an optimal pH 8.0 and optimal temperature 50  C for substrate Leu-p-nitroanilide and it sustained 50 % activity after 1 h incubation at 50  C. The activity of rLap1 was significantly inhibited by EDTA, whereas Co(2+), Mn(2+), and Ca(2+) ions, but not Zn(2+) ions, restored its activity.	Zinc	285-291	alanyl aminopeptidase, membrane	Rattus norvegicus	193-198
26003525-6	2015	Cations such as Na(+), K(+) and Mg(2+) slightly inhibited the activity of recombinant human GOT1, while Zn(2+), Mn(2+), Cu(2+), Ni(2+), Co(2+) and Ca(2+) had stronger inhibitory effects.	Zinc	104-110	glutamic-oxaloacetic transaminase 1	Homo sapiens	92-96
26187352-7	2015	Therefore, a correlation exists between the N-terminal loop and anti-cancer properties of endostatin fragment and a disulfide loop may be more promising than a Zn binding loop for inhibiting tumor growth.	Zinc	160-162	collagen type XVIII alpha 1 chain	Homo sapiens	90-100
26286729-2	2015	Using a rat model that recapitulates features of human ESCC, the mechanism whereby Zn regulates miR-31 expression to promote ESCC is examined.	Zinc	83-85	microRNA 31	Homo sapiens	96-102
27114935-2	2016	The objective of this study was to assess the effect of SMD-2 on the levels of urinary copper (Cu), zinc (Zn), and selenium (Se) in lung cancer patients and head and neck cancer patients receiving chemoradiotherapy.	Zinc	106-108	small nuclear ribonucleoprotein D2 polypeptide	Homo sapiens	56-61
26018933-4	2015	The mutants allow us to demonstrate convincingly the preparation of a mixed-metal analogue, Co(C)Zn(S)-MMP-1, with Zn(II) in the structural site and Co(II) in the catalytic site.	Zinc	115-121	matrix metallopeptidase 1	Homo sapiens	103-108
15563730-2	2005	Semen contains a high concentration of Zn2+, which is known to inhibit the protease activity of PSA.	Zinc	39-43	kallikrein related peptidase 3	Homo sapiens	96-99
15563730-3	2005	We characterized the binding of Zn2+ to SgI and SgII and found evidence that these proteins are involved in regulating the activity of PSA.	Zinc	32-36	semenogelin 1	Homo sapiens	40-43
26018933-5	2015	Stopped-flow fluorescence of the native form, Zn(C)Zn(S)-MMP-1, and the mixed-metal Co(C)Zn(S)-MMP-1 analogue shows that the internal fluorescence of a nearby Trp residue is modulated with catalysis and can be used to monitor reactivity under a number of conditions, opening the door to substrate profiling.	Zinc	46-48	matrix metallopeptidase 1	Homo sapiens	57-62
15563730-3	2005	We characterized the binding of Zn2+ to SgI and SgII and found evidence that these proteins are involved in regulating the activity of PSA.	Zinc	32-36	semenogelin 2	Homo sapiens	48-52
15563730-3	2005	We characterized the binding of Zn2+ to SgI and SgII and found evidence that these proteins are involved in regulating the activity of PSA.	Zinc	32-36	kallikrein related peptidase 3	Homo sapiens	135-138
26018933-5	2015	Stopped-flow fluorescence of the native form, Zn(C)Zn(S)-MMP-1, and the mixed-metal Co(C)Zn(S)-MMP-1 analogue shows that the internal fluorescence of a nearby Trp residue is modulated with catalysis and can be used to monitor reactivity under a number of conditions, opening the door to substrate profiling.	Zinc	46-48	matrix metallopeptidase 1	Homo sapiens	95-100
15563730-7	2005	SgI and SgII bound Zn2+ with a stoichiometry of at least 10 mol (mol of protein)(-1) and with an average dissociation constant of approx.	Zinc	19-23	semenogelin 1	Homo sapiens	0-3
15563730-7	2005	SgI and SgII bound Zn2+ with a stoichiometry of at least 10 mol (mol of protein)(-1) and with an average dissociation constant of approx.	Zinc	19-23	semenogelin 2	Homo sapiens	8-12
26018933-5	2015	Stopped-flow fluorescence of the native form, Zn(C)Zn(S)-MMP-1, and the mixed-metal Co(C)Zn(S)-MMP-1 analogue shows that the internal fluorescence of a nearby Trp residue is modulated with catalysis and can be used to monitor reactivity under a number of conditions, opening the door to substrate profiling.	Zinc	51-53	matrix metallopeptidase 1	Homo sapiens	57-62
15563730-9	2005	Moreover, Zn2+-inhibited PSA was activated by exposure to SgI or SgII.	Zinc	10-14	kallikrein related peptidase 3	Homo sapiens	25-28
15563730-9	2005	Moreover, Zn2+-inhibited PSA was activated by exposure to SgI or SgII.	Zinc	10-14	semenogelin 1	Homo sapiens	58-61
26018933-5	2015	Stopped-flow fluorescence of the native form, Zn(C)Zn(S)-MMP-1, and the mixed-metal Co(C)Zn(S)-MMP-1 analogue shows that the internal fluorescence of a nearby Trp residue is modulated with catalysis and can be used to monitor reactivity under a number of conditions, opening the door to substrate profiling.	Zinc	51-53	matrix metallopeptidase 1	Homo sapiens	95-100
15563730-9	2005	Moreover, Zn2+-inhibited PSA was activated by exposure to SgI or SgII.	Zinc	10-14	semenogelin 2	Homo sapiens	65-69
15563730-10	2005	Since both proteins have high affinity for Zn2+ and are the dominating proteins in semen, they probably represent the major Zn2+ binders in semen, one function of which may be to regulate the activity of PSA.	Zinc	124-128	kallikrein related peptidase 3	Homo sapiens	204-207
25840866-5	2015	Principal component (PC) analysis showed that PC1, PC2 and PC3 in the east were correlated to Pb+Cr+Zn+Cd, As+Cd and Cu, respectively, and they were correlated to Pb+Cr, Zn+Cu+Cd and As+Cu, respectively, in the west.	Zinc	100-102	proprotein convertase subtilisin/kexin type 1	Homo sapiens	46-49
15871276-12	2005	Moreover, the fat and oil phases produced during this method act as chelating agents to catch metal ions with an order of recovery of Cu2+ &gt; Zn2+ &gt; Cd2+ and Zn2+ &gt; Cu2+ &gt; Cd2+, respectively.	Zinc	144-148	CD2 molecule	Homo sapiens	154-157
15784978-4	2005	The deduced amino acid sequence of bmSOD indicated that the residues forming the Cu/Zn binding site are conserved and that the sequence is in 60% identity to that of the Drosophila melanogaster.	Zinc	84-86	superoxide dismutase [Cu-Zn]	Bombyx mori	35-40
15551063-9	2005	Effects of Zn(2+) on bcl-2/bax ratio were confirmed in apoptotic camptothecin-treated SHE cells.	Zinc	11-13	apoptosis regulator BAX	Mesocricetus auratus	27-30
15757339-5	2005	Atentative complexation/ electrochemical model is proposed for when both metal ions, Cd2+ and Zn2+, compete toward complexation, and some of the corresponding equilibrium constants are estimated.	Zinc	94-98	CD2 molecule	Homo sapiens	85-88
15641773-4	2005	(2003) Biochemistry 42, 9937] suggested that the isolated p300 TAZ1 domain lacks a well-defined structure and behaves like a molten globule, even in the presence of Zn(2+), and that the formation of a stable three-dimensional structure requires binding of a protein partner.	Zinc	165-167	zinc finger and BTB domain containing 18	Homo sapiens	63-67
16327072-3	2005	We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this study.	Zinc	52-54	insulin-like growth factor binding protein 3	Rattus norvegicus	142-186
15664000-12	2005	A specific, dose-dependent and Zn-dependent protein interaction between secPHEX and immobilized MEPE occurs (EC50 of 553 nM).	Zinc	31-33	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	Mus musculus	96-100
15606252-1	2004	To provide very accurate reference results for the second-order Moller-Plesset (MP2) energy and its various components for Zn(2+), which plays for 3d-electron systems a similar role as Ne for smaller atoms and molecules, we have performed extensive calculation by two completely different implementations of the MP2 method: the finite element method (FEM) and the variation-perturbation (VP) method.	Zinc	123-125	tryptase pseudogene 1	Homo sapiens	80-83
15606252-1	2004	To provide very accurate reference results for the second-order Moller-Plesset (MP2) energy and its various components for Zn(2+), which plays for 3d-electron systems a similar role as Ne for smaller atoms and molecules, we have performed extensive calculation by two completely different implementations of the MP2 method: the finite element method (FEM) and the variation-perturbation (VP) method.	Zinc	123-125	tryptase pseudogene 1	Homo sapiens	312-315
15590066-7	2004	Coupling the knowledge that biometals such as zinc are highly concentrated in the amyloid deposits in AD and S100A6 having a high affinity for Zn(2+) may suggest that S100A6 plays a role in AD neuropathology.	Zinc	143-145	S100 calcium binding protein A6 (calcyclin)	Mus musculus	109-115
15590066-7	2004	Coupling the knowledge that biometals such as zinc are highly concentrated in the amyloid deposits in AD and S100A6 having a high affinity for Zn(2+) may suggest that S100A6 plays a role in AD neuropathology.	Zinc	143-145	S100 calcium binding protein A6 (calcyclin)	Mus musculus	167-173
18404403-7	2004	Replacement of His-132 in the hP2Y(1) receptor with either Ala or Phe increased Zn(2+) sensitivity of the T(in) current.	Zinc	80-82	purinergic receptor P2Y1	Homo sapiens	30-46
15522710-14	2004	The relative selectivity coefficients of imprinted beads for Cd2+/Pb2+ and Cd2+/Zn2+ were 7.8 and 1683 times greater than non-imprinted matrix, respectively.	Zinc	80-84	CD2 molecule	Homo sapiens	75-78
15270717-4	2004	The metal-activation profiles for these additional GlxIs firmly establish the existence of a non-Zn2+-dependent grouping within the general category of GlxI enzymes.	Zinc	97-101	glyoxalase I	Homo sapiens	51-55
15270717-6	2004	Amino acid sequence comparisons indicate a more extended peptide chain in the Zn2+-dependent forms of GlxI (H. sapiens, P. putida and S. cerevisiae), compared with the GlxI enzymes of E. coli, Y. pestis, P. aeruginosa and N. meningitidis.	Zinc	78-82	glyoxalase I	Homo sapiens	102-106
15504453-1	2004	Mammalian porphobilinogen synthase (PBGS) is a metalloenzyme, which requires Zn2+ and reduced thiol groups for maximal catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Zinc	77-81	aminolevulinate dehydratase	Bos taurus	10-34
15504453-1	2004	Mammalian porphobilinogen synthase (PBGS) is a metalloenzyme, which requires Zn2+ and reduced thiol groups for maximal catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Zinc	77-81	aminolevulinate dehydratase	Bos taurus	36-40
15504453-5	2004	Zn2+ restored completely aluminum-induced inhibitory effect on PBGS activity.	Zinc	0-4	aminolevulinate dehydratase	Bos taurus	63-67
15491138-5	2004	Circular dichroism, UV-vis, and NMR experiments carried out on the C-terminal domain of Eos (EosC) revealed that the two putative ZnFs (C1 and C2) are separable, i.e., capable of folding independently in the presence of Zn(II).	Zinc	130-132	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	136-145
15474044-0	2004	An episodic ataxia type-1 mutation in the S1 segment sensitises the hKv1.1 potassium channel to extracellular Zn2+.	Zinc	110-114	potassium voltage-gated channel subfamily A member 1	Homo sapiens	68-74
15516700-6	2004	Both Cr and Zn could phosphorylate insulin receptor substrate-1 (IRS-1).	Zinc	12-14	insulin receptor substrate 1	Homo sapiens	35-63
15516700-6	2004	Both Cr and Zn could phosphorylate insulin receptor substrate-1 (IRS-1).	Zinc	12-14	insulin receptor substrate 1	Homo sapiens	65-70
15349162-1	2004	Metal selenocarboxylate salts (PPh4)[M(SeC[O]Tol)3] (M = Zn (1), Cd (2) and Hg (3); Tol = C6H4-p-CH3) have been synthesized by reacting Zn(NO3)2 .6H2O, Cd(NO3)2 .4H2O or HgCl2 with (Na+)TolC[O]Se- and PPh4Cl in the ratio of 1 : 4 : 1.	Zinc	57-59	potassium two pore domain channel subfamily K member 3	Homo sapiens	31-35
15261115-0	2004	Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons.	Zinc	74-78	carbonic anhydrase 1	Rattus norvegicus	118-121
15236578-7	2004	This observation is inconsistent with a rhodopsin-like structure, which would locate Ile(234) on the lipid-exposed side of TM5, too distant from other residues making up the Zn(2+)-binding site.	Zinc	174-180	rhodopsin	Rattus norvegicus	40-49
15222747-2	2004	These GATA fingers require Zn(2+) to fold, to bind DNA recognition elements, and to regulate transcription.	Zinc	27-29	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	6-10
15222747-4	2004	Co(2+) was used as a spectroscopic probe in a series of competition titrations to determine the affinity of Co(2+) and Zn(2+) for the C-terminal finger from chicken GATA-1 and the double finger from human GATA-1 (referred to in this report as CF and DF).	Zinc	119-125	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	165-171
15134923-1	2004	Properties of the metal ion binding sites of Zn-transcription factor IIIA (TFIIIA) were investigated to understand the potential of this type of zinc finger to undergo reactions that remove Zn(2+) from the protein.	Zinc	45-47	general transcription factor 3A L homeolog	Xenopus laevis	75-81
15134923-2	2004	Zn-TFIIIA was purified from E. coli containing the cloned sequence for Xenopus laevis oocyte TFIIIA and its stoichiometry of bound Zn(2+) was shown to depend on the details of the isolation process.	Zinc	0-2	general transcription factor 3A L homeolog	Xenopus laevis	3-9
15134923-2	2004	Zn-TFIIIA was purified from E. coli containing the cloned sequence for Xenopus laevis oocyte TFIIIA and its stoichiometry of bound Zn(2+) was shown to depend on the details of the isolation process.	Zinc	0-2	general transcription factor 3A L homeolog	Xenopus laevis	93-99
15100400-4	2004	Whereas the individual mutants exhibited no apparent phenotype, hma2 hma4 double mutants had a nutritional deficiency phenotype that could be compensated for by increasing the level of Zn, but not Cu or Co, in the growth medium.	Zinc	185-187	heavy metal atpase 2	Arabidopsis thaliana	64-68
15100400-5	2004	Levels of Zn, but not other essential elements, in the shoot tissues of a hma2 hma4 double mutant and, to a lesser extent, of a hma4 single mutant were decreased compared with the wild type.	Zinc	10-12	heavy metal atpase 2	Arabidopsis thaliana	74-78
15100400-6	2004	Together, these observations indicate a primary role for HMA2 and HMA4 in essential Zn homeostasis.	Zinc	84-86	heavy metal atpase 2	Arabidopsis thaliana	57-61
15100400-10	2004	These observations are consistent with a role for HMA2 and HMA4 in Zn translocation.	Zinc	67-69	heavy metal atpase 2	Arabidopsis thaliana	50-54
15050736-3	2004	The enzymatic activity of purified PSA was strongly inhibited by Zn(2+).	Zinc	65-67	kallikrein related peptidase 3	Homo sapiens	35-38
15050736-4	2004	The ability of LNCaP cells which express and secrete PSA to invade Matrigel was strongly suppressed by Zn(2+) at a concentration similar to that inhibiting the activity of purified PSA.	Zinc	103-109	kallikrein related peptidase 3	Homo sapiens	53-56
15050736-5	2004	Zn(2+) effectively inhibited the degradation of Matrigel by purified PSA.	Zinc	0-2	kallikrein related peptidase 3	Homo sapiens	69-72
15050736-6	2004	These results suggest that Zn(2+) in human prostate may suppress the invasion and metastasis of prostate cancer cells through the regulation of the proteolytic activity of PSA.	Zinc	27-29	kallikrein related peptidase 3	Homo sapiens	172-175
15050736-7	2004	Loss of inhibition of the proteolytic activity of PSA by Zn(2+) in prostate tumors could contribute to invasion.	Zinc	57-59	kallikrein related peptidase 3	Homo sapiens	50-53
12972402-5	2004	Neutralizing antibodies against EGFR ligands revealed the involvement of heparin-binding EGF (HB-EGF) in Zn(2+)-induced EGFR phosphorylation.	Zinc	105-107	heparin binding EGF like growth factor	Homo sapiens	73-92
12972402-5	2004	Neutralizing antibodies against EGFR ligands revealed the involvement of heparin-binding EGF (HB-EGF) in Zn(2+)-induced EGFR phosphorylation.	Zinc	105-107	heparin binding EGF like growth factor	Homo sapiens	94-100
12972402-6	2004	This observation was further supported by immunoblots showing elevated levels of HB-EGF released by Zn(2+)-exposed cells.	Zinc	100-106	heparin binding EGF like growth factor	Homo sapiens	81-87
15068813-7	2004	ZnO supplementation dose dependently increased the plasma Zn concentration and significantly increased amylase, lipase, trypsin and total protease activity in pancreatic homogenates and small intestinal contents.	Zinc	0-2	lipase G, endothelial type	Rattus norvegicus	112-118
15039103-6	2004	These findings suggest that GIF may inhibit Zn(2+)-induced neuronal death via its interaction with Rab3A.	Zinc	44-50	metallothionein 3	Rattus norvegicus	28-31
14610091-3	2004	MTF-1 proteins containing two Cys--&gt;Ala substitutions (C632A/C634A) or a deletion in this region altogether (Delta(632-644)) are significantly impaired in their ability to induce Zn(II)- and Cd(II)-responsive transcription of a MRE-linked reporter gene in transiently transfected mouse dko7 (MTF-1-/-) cells in culture under moderate metal stress but retain the ability to drive basal levels of transcription in a MRE-dependent manner in vivo and in vitro.	Zinc	182-184	metal response element binding transcription factor 1	Mus musculus	0-5
14765975-1	2004	Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands.	Zinc	6-12	insulin-like growth factor binding protein 3	Mus musculus	92-166
14765975-1	2004	Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands.	Zinc	6-12	insulin-like growth factor 2	Mus musculus	198-204
14765975-2	2004	However, there is a need for data concerning the effects of Zn(2+) on soluble IGFBPs and the type 2 IGF receptor (IGF-2R).	Zinc	60-66	insulin-like growth factor binding protein 3	Mus musculus	78-84
15070437-2	2004	The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption.	Zinc	21-23	solute carrier family 30 member 5	Homo sapiens	61-66
15070437-2	2004	The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption.	Zinc	21-23	solute carrier family 30 member 5	Homo sapiens	68-72
15070437-2	2004	The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption.	Zinc	21-23	solute carrier family 30 member 5	Homo sapiens	74-81
15070437-4	2004	hZTL1 mediates Zn uptake when expressed in Xenopus laevis oocytes and hZIP4 is mutated in most cases of the inherited Zn deficiency disease acrodermatitis enteropathica.	Zinc	15-17	solute carrier family 30 member 5	Homo sapiens	0-5
15070437-7	2004	Human intestinal Caco-2 cells show a similar response to increasing the Zn2+ concentration of the nutrient medium in relation to the expression of mRNA corresponding to several Zn transporters and that of ZnT1 (SLC30A1) and hZTL1/ZnT5 proteins.	Zinc	72-76	solute carrier family 30 member 5	Homo sapiens	224-229
15070437-7	2004	Human intestinal Caco-2 cells show a similar response to increasing the Zn2+ concentration of the nutrient medium in relation to the expression of mRNA corresponding to several Zn transporters and that of ZnT1 (SLC30A1) and hZTL1/ZnT5 proteins.	Zinc	72-76	solute carrier family 30 member 5	Homo sapiens	230-234
14622981-6	2003	In the presence of AA, 50 microM Zn enhanced mRNA expression of the osteoblastic differentiation markers alkaline phosphatase, alpha(1)(I) procollagen, osteopontin (OPN), and osteocalcin (OCN) by 3.9-, 3.8-, 3.3-, and 3.5-fold, respectively; in the absence of AA, the Zn-induced increase was 2.8-, 2.5-, 1.3-, and 1.1-fold, respectively.	Zinc	33-35	secreted phosphoprotein 1	Homo sapiens	152-163
14622981-6	2003	In the presence of AA, 50 microM Zn enhanced mRNA expression of the osteoblastic differentiation markers alkaline phosphatase, alpha(1)(I) procollagen, osteopontin (OPN), and osteocalcin (OCN) by 3.9-, 3.8-, 3.3-, and 3.5-fold, respectively; in the absence of AA, the Zn-induced increase was 2.8-, 2.5-, 1.3-, and 1.1-fold, respectively.	Zinc	33-35	secreted phosphoprotein 1	Homo sapiens	165-168
14629481-2	2003	Proteins such as gC1qR, cytokeratin-1 and u-PAR have been identified to be responsible for Zn2+-dependent binding of high molecular weight kininogen (HK) to HUVEC.	Zinc	91-95	plasminogen activator, urokinase receptor	Homo sapiens	42-47
12973678-1	2003	BACKGROUND &amp; AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	Zinc	102-106	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
14500983-3	2003	We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes.	Zinc	67-71	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
12851928-5	2003	This stability increase is identical for M(MeOPS) and M(UMPS) species and amounts to about 0.6 and 2.4 log units for Zn(PS) and Cd(PS), respectively.	Zinc	117-119	uridine monophosphate synthetase	Homo sapiens	56-60
12808046-5	2003	UNC-98 is a novel 310-residue polypeptide consisting of four C2H2 Zn fingers and several possible nuclear localization signal and nuclear export signal sequences.	Zinc	66-68	Zinc finger protein unc-98	Caenorhabditis elegans	0-6
12910288-3	2003	Sequence (GCC)8 in VLDL receptor gene forms specific complexes with nuclear proteins of HepG2 cells, the formation of these complexes depended on Zn(2+).	Zinc	146-148	very low density lipoprotein receptor	Homo sapiens	19-32
12682016-5	2003	The GCM domain exhibits a novel fold consisting of two domains tethered together by one of two structural Zn ions.	Zinc	106-108	glial cells missing	Drosophila melanogaster	4-7
12736367-0	2003	NMR and ICP spectroscopic analysis of the DNA-binding domain of the Drosophila GCM protein reveals a novel Zn2+ -binding motif.	Zinc	107-111	glial cells missing	Drosophila melanogaster	79-82
12736367-3	2003	In the DNA-binding region of this GCM protein, there is a cysteine-rich region with which divalent metal ions such as Zn(2+) must bind and other proteins belonging to the GCM family have a corresponding region.	Zinc	118-120	glial cells missing	Drosophila melanogaster	34-37
12736367-3	2003	In the DNA-binding region of this GCM protein, there is a cysteine-rich region with which divalent metal ions such as Zn(2+) must bind and other proteins belonging to the GCM family have a corresponding region.	Zinc	118-120	glial cells missing	Drosophila melanogaster	171-174
12556398-9	2003	Cd(2+) and Zn(2+) induced metallothionein IIa to five times higher levels than metallothionein Ig.	Zinc	11-13	metallothionein 2A	Homo sapiens	26-45
12556398-9	2003	Cd(2+) and Zn(2+) induced metallothionein IIa to five times higher levels than metallothionein Ig.	Zinc	11-13	metallothionein 1G	Homo sapiens	79-97
12566481-1	2003	This study examined the effects of graded intakes of zinc (Zn) and copper (Cu) on serum insulin-like growth-factor-I (IGF-I) concentration and bone quality in growing rats.	Zinc	59-61	insulin-like growth factor 1	Rattus norvegicus	88-116
12377780-4	2002	Zn(2+) binding to S100B is sufficient to promote interaction with IQGAP1.	Zinc	0-6	IQ motif containing GTPase activating protein 1	Homo sapiens	66-72
12377780-8	2002	They also reveal an additional cellular function for IQGAP1 associated with Zn(2+)/Ca(2+)-dependent relocation of S100B.	Zinc	76-82	IQ motif containing GTPase activating protein 1	Homo sapiens	53-59
12405537-6	2002	The obtained data indicate besides its neuronal growth inhibitory function, GIF might play a role in cellular Zn homeostasis in brain.	Zinc	110-112	cobalamin binding intrinsic factor	Homo sapiens	76-79
12438619-3	2002	Previous studies have demonstrated that hCycT1 binds Tat in a Zn(2+)-dependent manner via the cysteine at position 261, which is a tyrosine in murine cyclin T1.	Zinc	62-68	cyclin T1	Mus musculus	150-159
12204545-5	2002	Treatment with 20 mg/kg Zn prior to DNR, dramatically induced metallothionein-1 (MT-1) mRNA and MT protein in both heart and liver while DNR alone induced MT, but to a much lower degree than Zn.	Zinc	24-26	metallothionein 1I, pseudogene	Homo sapiens	81-85
12183328-0	2002	An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunit.	Zinc	34-36	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	83-88
12183328-6	2002	The Zn(2+)-sensitive spontaneous beta3 subunit-mediated conductance was also insensitive to block by Zn(2+) at pH 5.4.	Zinc	4-6	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	33-38
12183328-11	2002	External histidine residues in the beta3 receptor subunit were substituted with alanine, in addition to the background mutation, H267A, to assess their sensitivity to Zn(2+) inhibition.	Zinc	167-169	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	35-40
12183328-18	2002	GABA(A) receptor beta3 subunits form functional ion channels that can be inhibited by Zn(2+).	Zinc	86-88	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	17-22
12383231-0	2002	Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors.	Zinc	60-64	purinergic receptor P2X 2	Homo sapiens	110-114
12383231-9	2002	Together, these results suggest that Zn2+ is a potent modulator of glycinergic synaptic transmission which increases in a synergistic manner the agonist affinity of both presynaptic P2X2 receptors and postsynaptic GlyRs.	Zinc	37-41	purinergic receptor P2X 2	Homo sapiens	182-186
12146948-2	2002	Under ambient pressure, the dissociation constant, K(d)(Zn), of the ZnCytc/Cytb(5) complex was dependent on the buffer concentration, 1.5 and 12 microM in 2 and 10 mM Tris-HCl, pH 7.4, respectively, which was consistent with formation of salt bridges in its complexation.	Zinc	56-58	cytochrome b5 type A	Homo sapiens	75-82
12597030-4	2002	Low and high Zn, however, showed diverse effect on glutathione reductase.	Zinc	13-15	glutathione reductase 1	Zea mays	51-72
12597030-5	2002	While low Zn increased the activity of glutathione reductase, high Zn decreased its activity.	Zinc	10-12	glutathione reductase 1	Zea mays	39-60
12152085-3	2002	Here we present a 2.2 A crystal structure of the Rad50 coiled-coil region that reveals an unexpected dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn(2+) ion.	Zinc	234-236	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	49-54
12023845-5	2002	Both beta2-integrin- and uPAR-dependent processes are activated by Zn2+ and are blocked by high-molecular-mass kininogen.	Zinc	67-71	plasminogen activator, urokinase receptor	Homo sapiens	25-29
12561547-0	2002	[Effect of excessive Zn2+ and deficient Zn2+ on the expression of wild type-p53 mRNA in rat glicoma cells].	Zinc	21-25	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	76-79
12561547-0	2002	[Effect of excessive Zn2+ and deficient Zn2+ on the expression of wild type-p53 mRNA in rat glicoma cells].	Zinc	40-44	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	76-79
12561547-1	2002	RT-PCR is applied to observe the effects of excessive and deficient Zn2+ on the expression of wild type-p53 (wt-p53) in rat glicoma cells.	Zinc	68-72	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	104-107
12561547-1	2002	RT-PCR is applied to observe the effects of excessive and deficient Zn2+ on the expression of wild type-p53 (wt-p53) in rat glicoma cells.	Zinc	68-72	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115
25840866-5	2015	Principal component (PC) analysis showed that PC1, PC2 and PC3 in the east were correlated to Pb+Cr+Zn+Cd, As+Cd and Cu, respectively, and they were correlated to Pb+Cr, Zn+Cu+Cd and As+Cu, respectively, in the west.	Zinc	100-102	chromobox 4	Homo sapiens	51-54
12382908-4	2002	This presentation gives a comprehensive survey of the spectral and dose dependent RL properties of a number of luminescent materials like LiF:Mg,Ti, Al2O3:C, CaSO4:Dy, CaF2:Mn, Li2B4O7:Mn, BeO and ZnS:Ag.	Zinc	197-200	LIF interleukin 6 family cytokine	Homo sapiens	138-141
25840866-5	2015	Principal component (PC) analysis showed that PC1, PC2 and PC3 in the east were correlated to Pb+Cr+Zn+Cd, As+Cd and Cu, respectively, and they were correlated to Pb+Cr, Zn+Cu+Cd and As+Cu, respectively, in the west.	Zinc	100-102	proprotein convertase subtilisin/kexin type 1	Homo sapiens	59-62
25840866-5	2015	Principal component (PC) analysis showed that PC1, PC2 and PC3 in the east were correlated to Pb+Cr+Zn+Cd, As+Cd and Cu, respectively, and they were correlated to Pb+Cr, Zn+Cu+Cd and As+Cu, respectively, in the west.	Zinc	170-172	proprotein convertase subtilisin/kexin type 1	Homo sapiens	46-49
25840866-5	2015	Principal component (PC) analysis showed that PC1, PC2 and PC3 in the east were correlated to Pb+Cr+Zn+Cd, As+Cd and Cu, respectively, and they were correlated to Pb+Cr, Zn+Cu+Cd and As+Cu, respectively, in the west.	Zinc	170-172	proprotein convertase subtilisin/kexin type 1	Homo sapiens	59-62
25900616-2	2015	The goal of this study was to identify the -5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene, and to investigate its effect on allele-specific gene expression and Cd, Zn, Cu and Ni content in sinonasal inverted papilloma tissue (IP), with non-cancerous sinonasal mucosa (NCM) as a control.	Zinc	219-221	metallothionein 2A	Homo sapiens	135-139
11728393-2	2001	Complexes of these ligands with Zn(II) were isolated and characterized using elemental analysis, FTIR, UV-Vis absorption, NMR spectroscopic and FAB mass spectrometric techniques.	Zinc	32-38	FA complementation group B	Homo sapiens	144-147
12561611-6	2001	The result showed that the expression on area density and L-density (average optical density) of Hox3.5 in ZD and ZR groups were decreased in comparing with those in ZN group (P &lt; 0.05).	Zinc	166-168	homeobox C4	Mus musculus	97-103
25586622-9	2015	However, in the HT + Zn group, the histomorphology of the liver was restored, the serum aspartate aminotransferase (AST) level was significantly decreased, and the hepatic CuZn-SOD activity was significantly increased compared to the HT group.	Zinc	21-23	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	88-114
25586622-9	2015	However, in the HT + Zn group, the histomorphology of the liver was restored, the serum aspartate aminotransferase (AST) level was significantly decreased, and the hepatic CuZn-SOD activity was significantly increased compared to the HT group.	Zinc	21-23	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	116-119
11504925-5	2001	Like all of these effectors, Mlph possesses two Zn(2+)-binding CX(2)CX(13,14)CX(2)C motifs and a short aromatic-rich amino acid region that is critical for Rab binding.	Zinc	48-54	melanophilin	Mus musculus	29-33
25586622-11	2015	Zn might alleviate heat-induced hepatic injury as revealed by restored histomorphology and AST level.	Zinc	0-2	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	91-94
25607980-0	2015	Nuclear-translocated endostatin downregulates hypoxia inducible factor-1alpha activation through interfering with Zn(II) homeostasis.	Zinc	114-120	collagen type XVIII alpha 1 chain	Homo sapiens	21-31
11554452-6	2001	The inhibitory effect of o-phenanthroline on RPA-ssDNA interaction was reversed by Zn(II), but not by other divalent cations, suggesting that Zn(II) is the unique metal coordinating the zinc-finger cysteines in redox regulation of RPA-ssDNA interaction.	Zinc	83-85	replication protein A1	Homo sapiens	45-48
11554452-6	2001	The inhibitory effect of o-phenanthroline on RPA-ssDNA interaction was reversed by Zn(II), but not by other divalent cations, suggesting that Zn(II) is the unique metal coordinating the zinc-finger cysteines in redox regulation of RPA-ssDNA interaction.	Zinc	142-144	replication protein A1	Homo sapiens	45-48
11554452-6	2001	The inhibitory effect of o-phenanthroline on RPA-ssDNA interaction was reversed by Zn(II), but not by other divalent cations, suggesting that Zn(II) is the unique metal coordinating the zinc-finger cysteines in redox regulation of RPA-ssDNA interaction.	Zinc	142-144	replication protein A1	Homo sapiens	231-234
11483663-4	2001	Intracellular accumulation of Zn2+ induced by the combined application of pyrithione (5 microM), a Zn2+ ionophore, and Zn2+ (10 microM) caused cell death and activated JNK and ERK, but not p38 MAPK.	Zinc	30-34	mitogen-activated protein kinase 8	Rattus norvegicus	168-171
11483663-8	2001	Therefore, we conclude that although Zn2+ activates JNK and ERK, only ERK contributes to Zn2+-induced cell death, and that ERK activation is mediated by ROS via the Ras/Raf/MEK/ERK signaling pathway.	Zinc	37-41	mitogen-activated protein kinase 8	Rattus norvegicus	52-55
25607980-4	2015	The current study investigated the mechanism by which nuclear-translocated endostatin suppresses HIF-1alpha activation by disrupting Zn(II) homeostasis.	Zinc	133-139	collagen type XVIII alpha 1 chain	Homo sapiens	75-85
25607980-7	2015	Nuclear-translocated apo-endostatin, but not holo-endostatin, significantly disrupts the interaction between CBP/p300 and HIF-1alpha by disturbing Zn(II) homeostasis, which leads to the transcriptional inactivation of HIF-1alpha.	Zinc	147-149	collagen type XVIII alpha 1 chain	Homo sapiens	25-35
25919709-5	2014	MCT4-mediated lactate transport was inhibited by Zn2+ in a pH physiological condition but not in an acidic condition.	Zinc	49-53	solute carrier family 16 member 3 S homeolog	Xenopus laevis	0-4
11327731-6	2001	The SHD1 and SHD2 of Slp3-a and Slp4 are separated by a putative Zn(2+)-binding sequence, whereas Slp1 and Slp2 lack such Zn(2+)-binding sequences and their SHD1 and SHD2 are linked together.	Zinc	122-128	synaptotagmin-like 3	Mus musculus	21-27
11134057-1	2001	Multiple or pleiotropic drug resistance often arises in the yeast Saccharomyces cerevisiae due to genetic alterations of the functional state of the Cys(6)-Zn(II)(2) transcription factors Pdr1p and Pdr3p.	Zinc	156-158	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	188-193
11179023-6	2001	We found two duplication mutations in these families, at a cytosine tract in exon 10 of NEMO, both of which remove the zinc (Zn) finger at the C-terminus of the protein.	Zinc	125-127	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	88-92
11171056-1	2001	Metal activation of metallothionein gene transcription depends mainly on the presence of regulatory DNA sequences termed metal-regulatory elements (MREs) and involves MRE-binding transcription factor-1 (MTF-1) interacting with the MREs in a Zn(2+)-dependent manner.	Zinc	241-243	metal response element binding transcription factor 1	Mus musculus	167-201
11171056-1	2001	Metal activation of metallothionein gene transcription depends mainly on the presence of regulatory DNA sequences termed metal-regulatory elements (MREs) and involves MRE-binding transcription factor-1 (MTF-1) interacting with the MREs in a Zn(2+)-dependent manner.	Zinc	241-243	metal response element binding transcription factor 1	Mus musculus	203-208
11171056-8	2001	MTF-1 DNA-binding activity was rapidly activated in vivo by Zn(2+) ions but not by Cd(2+), UV irradiation or PMA, and occurred on ice as well as at 21 degrees C. In control and Zn(2+)-treated cell extracts, DNA-binding activity was not enhanced in vitro following the addition of exogenous Zn(2+) or a preincubation at 37 degrees C. However, recombinant MTF-1 produced in vitro required Zn(2+) activation for DNA binding.	Zinc	60-62	metal response element binding transcription factor 1	Mus musculus	0-5
11171056-8	2001	MTF-1 DNA-binding activity was rapidly activated in vivo by Zn(2+) ions but not by Cd(2+), UV irradiation or PMA, and occurred on ice as well as at 21 degrees C. In control and Zn(2+)-treated cell extracts, DNA-binding activity was not enhanced in vitro following the addition of exogenous Zn(2+) or a preincubation at 37 degrees C. However, recombinant MTF-1 produced in vitro required Zn(2+) activation for DNA binding.	Zinc	60-66	metal response element binding transcription factor 1	Mus musculus	0-5
11171056-8	2001	MTF-1 DNA-binding activity was rapidly activated in vivo by Zn(2+) ions but not by Cd(2+), UV irradiation or PMA, and occurred on ice as well as at 21 degrees C. In control and Zn(2+)-treated cell extracts, DNA-binding activity was not enhanced in vitro following the addition of exogenous Zn(2+) or a preincubation at 37 degrees C. However, recombinant MTF-1 produced in vitro required Zn(2+) activation for DNA binding.	Zinc	177-179	metal response element binding transcription factor 1	Mus musculus	0-5
11171056-8	2001	MTF-1 DNA-binding activity was rapidly activated in vivo by Zn(2+) ions but not by Cd(2+), UV irradiation or PMA, and occurred on ice as well as at 21 degrees C. In control and Zn(2+)-treated cell extracts, DNA-binding activity was not enhanced in vitro following the addition of exogenous Zn(2+) or a preincubation at 37 degrees C. However, recombinant MTF-1 produced in vitro required Zn(2+) activation for DNA binding.	Zinc	177-179	metal response element binding transcription factor 1	Mus musculus	0-5
11160420-0	2001	Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.	Zinc	56-60	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	79-92
11160420-1	2001	NMDA receptor activity is modulated by various compounds, including sulfhydryl redox agents and Zn(2+).	Zinc	96-102	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	0-13
11160420-2	2001	In addition to a slow and persistent component of redox modulation common to all NMDA receptors, NR1/NR2A receptors uniquely have a rapid and reversible component that has been variously attributed to redox or Zn(2+) effects.	Zinc	210-212	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	97-100
11440182-13	2001	Another general observation was that the complexes with Mn dications were more stable than those with Zn dications for both PP1c and PP2Ac units.	Zinc	102-104	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	133-138
25972885-0	2015	Integration of P, S, Fe, and Zn nutrition signals in Arabidopsis thaliana: potential involvement of PHOSPHATE STARVATION RESPONSE 1 (PHR1).	Zinc	29-31	phosphate starvation response 1	Arabidopsis thaliana	133-137
25923075-5	2015	Furthermore, the Zrt/Irt-like protein 3 (ZIP3)-defective mutant with an elevated Zn-deficient response exhibited higher Ni accumulation than the wild type, further supporting that the response to Zn deficiency induces Ni accumulation.	Zinc	81-83	zinc transporter 3 precursor	Arabidopsis thaliana	17-39
25923075-5	2015	Furthermore, the Zrt/Irt-like protein 3 (ZIP3)-defective mutant with an elevated Zn-deficient response exhibited higher Ni accumulation than the wild type, further supporting that the response to Zn deficiency induces Ni accumulation.	Zinc	81-83	zinc transporter 3 precursor	Arabidopsis thaliana	41-45
25923075-5	2015	Furthermore, the Zrt/Irt-like protein 3 (ZIP3)-defective mutant with an elevated Zn-deficient response exhibited higher Ni accumulation than the wild type, further supporting that the response to Zn deficiency induces Ni accumulation.	Zinc	196-198	zinc transporter 3 precursor	Arabidopsis thaliana	17-39
25923075-5	2015	Furthermore, the Zrt/Irt-like protein 3 (ZIP3)-defective mutant with an elevated Zn-deficient response exhibited higher Ni accumulation than the wild type, further supporting that the response to Zn deficiency induces Ni accumulation.	Zinc	196-198	zinc transporter 3 precursor	Arabidopsis thaliana	41-45
25724285-5	2015	While Zn and/or PQ elevated the total free radical generation, lipid peroxidation (LPO) and catalytic activity of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase alpha 4-4 (GSTA4-4), a pronounced decrease in reduced glutathione (GSH) and glutathione reductase (GR) activity was also observed.	Zinc	6-8	glutathione-disulfide reductase	Rattus norvegicus	300-321
25724285-5	2015	While Zn and/or PQ elevated the total free radical generation, lipid peroxidation (LPO) and catalytic activity of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase alpha 4-4 (GSTA4-4), a pronounced decrease in reduced glutathione (GSH) and glutathione reductase (GR) activity was also observed.	Zinc	6-8	glutathione-disulfide reductase	Rattus norvegicus	323-325
25724285-6	2015	Zn and/or PQ augmented the expression of metallothionein-I and II and GSTA4-4.	Zinc	0-2	glutathione S-transferase alpha 4	Rattus norvegicus	70-77
24939099-1	2015	The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group.	Zinc	156-158	transcription factor like 5	Homo sapiens	143-146
25793284-3	2015	Each inhibitor contains a pendant side chain thiol that coordinates to the active site Zn(2+) ion, as observed in the X-ray crystal structure of the HDAC8-Largazole complex [Cole, K. E., Dowling, D. P., Boone, M. A., Phillips, A. J., and Christianson, D. W. (2011) J.	Zinc	87-93	histone deacetylase 8	Homo sapiens	149-154
25485957-5	2015	Compared with Zn-stressed roots, catalase, soluble peroxidase (POD), ascorbate peroxidase and superoxide dismutase decreased in Zn+DPI-treated roots, suggesting that ROS generation from plasma membrane (PM) NADPH oxidase was associated with the regulation of antioxidant enzyme activities.	Zinc	128-130	catalase-1	Triticum aestivum	33-41
25485957-5	2015	Compared with Zn-stressed roots, catalase, soluble peroxidase (POD), ascorbate peroxidase and superoxide dismutase decreased in Zn+DPI-treated roots, suggesting that ROS generation from plasma membrane (PM) NADPH oxidase was associated with the regulation of antioxidant enzyme activities.	Zinc	128-130	peroxidase-like	Triticum aestivum	51-61
25485957-5	2015	Compared with Zn-stressed roots, catalase, soluble peroxidase (POD), ascorbate peroxidase and superoxide dismutase decreased in Zn+DPI-treated roots, suggesting that ROS generation from plasma membrane (PM) NADPH oxidase was associated with the regulation of antioxidant enzyme activities.	Zinc	128-130	peroxidase-like	Triticum aestivum	63-66
25485957-5	2015	Compared with Zn-stressed roots, catalase, soluble peroxidase (POD), ascorbate peroxidase and superoxide dismutase decreased in Zn+DPI-treated roots, suggesting that ROS generation from plasma membrane (PM) NADPH oxidase was associated with the regulation of antioxidant enzyme activities.	Zinc	128-130	peroxidase-like	Triticum aestivum	79-89
25485957-6	2015	Additionally, Zn-treated roots exhibited significant decreases in cell wall-bound POD, diamine oxidase and polyamine oxidase activities.	Zinc	14-16	peroxidase-like	Triticum aestivum	82-85
25408502-8	2015	The pro-apoptotic effects of Zn(2+) -chelation in combination with F10 treatment were enhanced by inhibiting Omi/HtrA2 implicating this serine protease as a novel target for prostate cancer treatment.	Zinc	29-31	HtrA serine peptidase 2	Homo sapiens	113-118
25408502-10	2015	The serine protease Omi/HtrA2 modulates Zn(2+) -dependent apoptosis in prostate cancer cells and represents a new target for treatment of CRPC.	Zinc	40-46	HtrA serine peptidase 2	Homo sapiens	24-29
25459509-1	2015	A new mononuclear Zn(II) complex, trans-[Zn(Pir)2(DMSO)2], where Pir(-) is 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (piroxicam), has been synthesized and characterized.	Zinc	18-24	ring finger protein 144B	Homo sapiens	44-49
25597679-4	2015	The MLK model was employed to simulate the adsorption kinetics of Cu(II), Co(II), Cd(II), Zn(II) and Ni(II) on MnO2 at pH3.2 or 3.3 to get the values of KS-kinetic.	Zinc	90-96	mitogen-activated protein kinase kinase kinase 13	Homo sapiens	4-7
25129612-7	2014	Significantly higher alpha smooth muscle actin mRNA and protein expression were measured after Zn (ASA)2 and Zn-treatment in comparison with the untreated and ASA-groups while the expression of matrix-metalloproteinase-9 was significantly higher in these groups compared to Zn (ASA)2.	Zinc	95-97	actin gamma 2, smooth muscle	Rattus norvegicus	21-46
25129612-7	2014	Significantly higher alpha smooth muscle actin mRNA and protein expression were measured after Zn (ASA)2 and Zn-treatment in comparison with the untreated and ASA-groups while the expression of matrix-metalloproteinase-9 was significantly higher in these groups compared to Zn (ASA)2.	Zinc	109-111	actin gamma 2, smooth muscle	Rattus norvegicus	21-46
25129612-7	2014	Significantly higher alpha smooth muscle actin mRNA and protein expression were measured after Zn (ASA)2 and Zn-treatment in comparison with the untreated and ASA-groups while the expression of matrix-metalloproteinase-9 was significantly higher in these groups compared to Zn (ASA)2.	Zinc	109-111	actin gamma 2, smooth muscle	Rattus norvegicus	21-46
24841088-4	2014	In the fluorescence "turn-on" step, the strong binding ability between Zn(2+) and CMCS on the surface of QDs can enhance the photoluminescence intensity (PL) of QDs.	Zinc	71-73	G protein signaling modulator 2	Homo sapiens	82-86
25189342-0	2014	A Cd/Fe/Zn-responsive phytochelatin synthase is constitutively present in the ancient liverwort Lunularia cruciata (L.) dumort.	Zinc	8-10	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	22-44
25089007-2	2014	MAIN METHODS: mZIP1 cDNA, which was cloned from mouse microglia, was transfected into HEK293T cells by a lipofection method, and its functional expression was confirmed by Western blotting and immunocytochemical analyses, and (65)Zn ((65)ZnCl2) uptake.	Zinc	230-232	solute carrier family 39 (zinc transporter), member 1	Mus musculus	14-19
25089007-3	2014	KEY FINDINGS: (65)Zn uptake by mZIP1 cDNA-transfected cells time-dependently increased compared with that by mock cells, indicating functional expression of mZIP1.	Zinc	18-20	solute carrier family 39 (zinc transporter), member 1	Mus musculus	31-36
25089007-3	2014	KEY FINDINGS: (65)Zn uptake by mZIP1 cDNA-transfected cells time-dependently increased compared with that by mock cells, indicating functional expression of mZIP1.	Zinc	18-20	solute carrier family 39 (zinc transporter), member 1	Mus musculus	157-162
25089007-4	2014	mZIP1-mediated (65)Zn uptake showed clear saturable kinetics consisting of a single component with a Michaelis constant of 5.88 muM.	Zinc	19-21	solute carrier family 39 (zinc transporter), member 1	Mus musculus	0-5
25089007-6	2014	In addition, CoCl2 and CdCl2 showed non-competitive inhibition of mZIP1-mediated (65)Zn uptake, the Ki values being 219 and 32.5 muM, respectively.	Zinc	85-87	solute carrier family 39 (zinc transporter), member 1	Mus musculus	66-71
24254232-0	2014	Optical and structural characterization of CdS/ZnS and CdS:Cu(2+) /ZnS core-shell nanoparticles.	Zinc	67-70	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
24254232-1	2014	Core-shell CdS/ZnS (Zn 0.025-0.125 M) and CdS:Cu(2+) (1%)/ZnS nanoparticles were successfully synthesized using a chemical method.	Zinc	15-17	CDP-diacylglycerol synthase 1	Homo sapiens	11-14
24254232-1	2014	Core-shell CdS/ZnS (Zn 0.025-0.125 M) and CdS:Cu(2+) (1%)/ZnS nanoparticles were successfully synthesized using a chemical method.	Zinc	58-61	CDP-diacylglycerol synthase 1	Homo sapiens	42-45
24254232-2	2014	X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR TEM), photoluminescence (PL) and UV/Visible (UV/Vis) techniques were used to characterize the novel CdS/ZnS and CdS:Cu(2+) /ZnS core-shell nanoparticles.	Zinc	182-185	CDP-diacylglycerol synthase 1	Homo sapiens	178-181
24254232-2	2014	X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR TEM), photoluminescence (PL) and UV/Visible (UV/Vis) techniques were used to characterize the novel CdS/ZnS and CdS:Cu(2+) /ZnS core-shell nanoparticles.	Zinc	202-205	CDP-diacylglycerol synthase 1	Homo sapiens	178-181
24254232-4	2014	Very narrow and symmetric PL emission was observed in the yellow region for core-shell CdS/ZnS.	Zinc	91-94	CDP-diacylglycerol synthase 1	Homo sapiens	87-90
24254232-5	2014	Furthermore, the PL emission of CdS/ZnS was tuned into orange region by incorporate the Cu ion into the core CdS lattice.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	32-35
24254232-5	2014	Furthermore, the PL emission of CdS/ZnS was tuned into orange region by incorporate the Cu ion into the core CdS lattice.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	109-112
25054451-10	2014	Collectively, these results demonstrate that Mt3 may act through PDE3a to play a key role in Zn dyshomeostasis and cell death in STZ-treated islets.	Zinc	93-95	metallothionein 3	Mus musculus	45-48
25162517-4	2014	In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1.	Zinc	147-149	metallothionein 1I, pseudogene	Homo sapiens	197-201
25162517-4	2014	In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1.	Zinc	147-149	solute carrier family 39 member 1	Homo sapiens	264-269
25006697-4	2014	Specifically, we will focus on heme peroxidases, metallo-beta-lactamases, alpha-synuclein and ligase ribozymes to show how this approach is capable of describing the catalytic and/or structural role played by transition (Fe, Zn or Cu) and main group (Mg) metals.	Zinc	225-227	synuclein alpha	Homo sapiens	74-89
24264723-8	2014	Importantly, overexpression of GPR39 in HEK293 cells is sufficient to trigger Zn(2+) -dependent responses.	Zinc	78-84	G protein-coupled receptor 39	Homo sapiens	31-36
24264723-11	2014	Finally, we show that in PC3 cells ZnR/GPR39 is required for mediating the Zn(2+) -dependent activation of MAPK and PI3K, pathways leading to enhanced cell growth.	Zinc	75-81	G protein-coupled receptor 39	Homo sapiens	39-44
24264723-12	2014	Importantly, Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells.	Zinc	13-19	G protein-coupled receptor 39	Homo sapiens	49-54
24334770-9	2014	Zn(2+) stress also caused increased expression of alpha-Syn and consequently decreased activity of the lysosomal enzyme glucocerebrosidase.	Zinc	0-2	synuclein alpha	Homo sapiens	50-59
24334770-10	2014	Together, these data suggest that PARK9 loss of function leads to dyshomeostasis of intracellular Zn(2+) that in turn contributes to lysosomal dysfunction and accumulation of alpha-Syn.	Zinc	98-100	synuclein alpha	Homo sapiens	175-184
24597671-6	2014	Zn supplement prevented the effects of TPEN and also increased Akt and GSK-3beta phosphorylation with a decrease in Nrf2 nuclear exporter, Fyn.	Zinc	0-2	glycogen synthase kinase 3 beta	Mus musculus	71-80
24552592-0	2014	Photosensitized singlet oxygen luminescence from the protein matrix of Zn-substituted myoglobin.	Zinc	71-73	myoglobin	Homo sapiens	86-95
22422511-5	2014	Levels of lipid peroxidation (LPx) and activities of catalase and glutathione-S-transferase (GST) were significantly decreased following Al treatment, which, however, were increased significantly in Zn co-treated rats.	Zinc	199-201	hematopoietic prostaglandin D synthase	Rattus norvegicus	66-91
22422511-5	2014	Levels of lipid peroxidation (LPx) and activities of catalase and glutathione-S-transferase (GST) were significantly decreased following Al treatment, which, however, were increased significantly in Zn co-treated rats.	Zinc	199-201	hematopoietic prostaglandin D synthase	Rattus norvegicus	93-96
24581221-8	2014	Importantly, the metal-complex, ZnII(atsm), induced Zip7 upregulation, promoted Zn redistribution and restored Zn-dependent functions in primary mouse Cln6 deficient neurons and astrocytes.	Zinc	32-34	solute carrier family 39 (zinc transporter), member 7	Mus musculus	52-56
24313328-5	2014	Using this new approach, we then determined the Zn binding site of beta-2-microglobulin, a protein associated with metal-induced amyloidosis.	Zinc	48-50	beta-2-microglobulin	Homo sapiens	67-87
24049181-8	2013	Residues H71 and H116 in Delta2 LHBS, which also contact Zn(2+) ions, are also indispensable for Delta2 LHBS-mediated p27(Kip1) degradation in human HuH7 cells.	Zinc	57-59	cyclin dependent kinase inhibitor 1B	Homo sapiens	122-126
23962989-1	2013	In the present study, we investigated possible roles of the zinc (Zn)-binding protein metallothionein-3 (MT3) and cellular Zn in a mouse model of laser-induced choroidal neovascularization (CNV) using wild-type (WT) and MT3-knockout (KO) mice.	Zinc	66-68	metallothionein 3	Mus musculus	86-103
23962989-10	2013	Consistent with the possible involvement of Zn released from MT3, raising intracellular Zn levels increased VEGF levels and activated its receptor, Flk-1, in both WT and MT3-KO retinal cells.	Zinc	44-46	metallothionein 3	Mus musculus	61-64
23962989-10	2013	Consistent with the possible involvement of Zn released from MT3, raising intracellular Zn levels increased VEGF levels and activated its receptor, Flk-1, in both WT and MT3-KO retinal cells.	Zinc	88-90	metallothionein 3	Mus musculus	61-64
23962989-10	2013	Consistent with the possible involvement of Zn released from MT3, raising intracellular Zn levels increased VEGF levels and activated its receptor, Flk-1, in both WT and MT3-KO retinal cells.	Zinc	88-90	metallothionein 3	Mus musculus	170-173
23962989-12	2013	Moreover, Zn released from MT3 may contribute to VEGF induction.	Zinc	10-12	metallothionein 3	Mus musculus	27-30
23643911-0	2013	Soft-binding ligand-capped fluorescent CdSe/ZnS quantum dots for the facile labeling of polysaccharide-based self-assemblies.	Zinc	44-47	POC1 centriolar protein A	Homo sapiens	0-4
23835914-5	2013	Zn(II) competition experiments with the metal ion chelator 4-(2-pyridylazo)resorcinol (PAR) in the presence of the cellular redox pair glutathione (GSH)/glutathione disulfide (GSSG) show that plant MTs from the subfamilies MT1, MT2, and MT3 are remarkably more affected by oxidative stress than those from the Ec subfamily and the well-characterized human MT2 form.	Zinc	0-6	metallothionein 1I, pseudogene	Homo sapiens	223-226
23835914-5	2013	Zn(II) competition experiments with the metal ion chelator 4-(2-pyridylazo)resorcinol (PAR) in the presence of the cellular redox pair glutathione (GSH)/glutathione disulfide (GSSG) show that plant MTs from the subfamilies MT1, MT2, and MT3 are remarkably more affected by oxidative stress than those from the Ec subfamily and the well-characterized human MT2 form.	Zinc	0-6	metallothionein 2A	Homo sapiens	228-231
23835914-5	2013	Zn(II) competition experiments with the metal ion chelator 4-(2-pyridylazo)resorcinol (PAR) in the presence of the cellular redox pair glutathione (GSH)/glutathione disulfide (GSSG) show that plant MTs from the subfamilies MT1, MT2, and MT3 are remarkably more affected by oxidative stress than those from the Ec subfamily and the well-characterized human MT2 form.	Zinc	0-6	metallothionein 2A	Homo sapiens	356-359
23801188-3	2013	The results show that CdS and ZnS interfaces produce an electron charge transfer from the CdS electron-populated clusters to the ZnS hole-populated clusters which helps to enhance the photocatalytic activity of the CdS@ZnS decorated system.	Zinc	129-132	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
23735664-5	2013	The Zn supplement prevented a decrease in the activity and mRNA of alkaline phosphatase (ALP), osteocalcin mRNA, and hydroxyproline and calcium levels, and an increase in the activity and mRNA of tartrate-resistant acid phosphatase (TRAP) and cathepsin K in the proximal tibia of diabetic rats.	Zinc	4-6	cathepsin K	Rattus norvegicus	243-254
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	insulin-like growth factor 1	Rattus norvegicus	175-180
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	catenin beta 1	Rattus norvegicus	201-213
22846892-0	2013	Human S100A3 tetramerization propagates Ca(2+)/Zn(2+) binding states.	Zinc	47-53	S100 calcium binding protein A3	Homo sapiens	6-12
22846892-2	2013	Each S100A3 subunit contains two EF-hand-type Ca(2+)-binding motifs and one (Cys)3His-type Zn(2+)-binding site in the C-terminus.	Zinc	91-97	S100 calcium binding protein A3	Homo sapiens	5-11
22846892-4	2013	The aim of this study was to determine the structural and functional role of the C-terminal Zn(2+)-binding domain, which is unique to S100A3, in homotetramer assembly.	Zinc	92-98	S100 calcium binding protein A3	Homo sapiens	134-140
22846892-5	2013	The binding of either Ca(2+) or Zn(2+) reduced the alpha-helix content of S100A3 and modulated its affinity for the other cation.	Zinc	32-38	S100 calcium binding protein A3	Homo sapiens	74-80
22846892-6	2013	The binding of a single Zn(2+) accelerated the Ca(2+)-dependent tetramerization of S100A3 while inducing an extensive unfolding of helix IV.	Zinc	24-30	S100 calcium binding protein A3	Homo sapiens	83-89
22846892-7	2013	The Ca(2+) and Zn(2+) binding affinities of S100A3 were enhanced when the other cation bound in concert with the tetramerization of S100A3.	Zinc	15-21	S100 calcium binding protein A3	Homo sapiens	44-50
22846892-7	2013	The Ca(2+) and Zn(2+) binding affinities of S100A3 were enhanced when the other cation bound in concert with the tetramerization of S100A3.	Zinc	15-21	S100 calcium binding protein A3	Homo sapiens	132-138
23401182-8	2013	It is generally understood that imbalances in Cu and Zn levels may lead to a higher prevalence of p53 mutations.	Zinc	53-55	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	98-101
23700340-8	2013	Furthermore, gene expression of macrophage-specific markers ADAM8 (A disintegrin and metalloproteinase domain-containing protein 8) and CD68 (cluster of differentiation 68) was significantly greater in adipose tissue in the HFD-Zn group than in the HFD group, as confirmed by CD68 protein analysis, indicative of increased macrophage infiltration.	Zinc	228-230	a disintegrin and metallopeptidase domain 8	Mus musculus	60-65
23924759-3	2013	PIF1 is very sensitive to temperature, whereas it is not affected by pH, and the ATPase activity of human PIF1 is dependent on the divalent cations Mg (2+) and Mn (2+) but not Ca (2+) and Zn (2+).	Zinc	188-190	PIF1 5'-to-3' DNA helicase	Homo sapiens	106-110
23785420-8	2013	The CD9-positive microvesicles transferred molecules to the same sperm regions (acrosome and midpiece) as epididymosomes, with the same kinetics; however, the molecules were preferentially transferred to live sperm and, in contrast to epididymosomes, Zn(2+) did not demonstrate potentiated transfer.	Zinc	251-253	CD9 molecule	Bos taurus	4-7
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Zinc	185-191	selectin P	Homo sapiens	63-67
23652332-6	2013	SelM" (U48C) and SelP-H were found to coordinate 0.5 and 2 molar equivalents of Zn(2+)/Cd(2+) with micromolar and submicromolar affinities, respectively.	Zinc	80-82	selectin P	Homo sapiens	17-21
23590825-8	2013	Zn-deficiency-mediated induction of HMA2 in roots and shoots suggested its role in effluxing Zn into xylem for long-distance transport.	Zinc	0-2	heavy metal atpase 2	Arabidopsis thaliana	36-40
23590825-8	2013	Zn-deficiency-mediated induction of HMA2 in roots and shoots suggested its role in effluxing Zn into xylem for long-distance transport.	Zinc	93-95	heavy metal atpase 2	Arabidopsis thaliana	36-40
23294838-12	2013	These findings provide important information for TaHMA2, and more efforts should be made in the future to characterize the reduced Zn concentration in TaHMA2 transgenic grains and the diversity of TaHMA2 substrate specificity.	Zinc	131-133	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	151-157
23294838-12	2013	These findings provide important information for TaHMA2, and more efforts should be made in the future to characterize the reduced Zn concentration in TaHMA2 transgenic grains and the diversity of TaHMA2 substrate specificity.	Zinc	131-133	cadmium/zinc-transporting ATPase HMA2	Triticum aestivum	151-157
23772397-1	2013	The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop).	Zinc	13-15	zinc transporter	Arabidopsis thaliana	61-67
23575356-8	2013	RESULTS: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship.	Zinc	100-102	serpin family B member 3	Homo sapiens	44-47
23575356-10	2013	As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P &lt; 0.01) and Zn (P = 0.02) for lung AC.	Zinc	145-147	serpin family B member 3	Homo sapiens	167-170
23168272-1	2013	The aim of the present study was to analyse the sequence variability of the porcine Zip4-like Zn transporter gene and the association of identified sequence variants with average daily gain, apparent Zn absorption, plasma Zn concentration and Zn concentration in the liver and pancreas.	Zinc	94-96	solute carrier family 39 member 4	Sus scrofa	84-88
23168272-1	2013	The aim of the present study was to analyse the sequence variability of the porcine Zip4-like Zn transporter gene and the association of identified sequence variants with average daily gain, apparent Zn absorption, plasma Zn concentration and Zn concentration in the liver and pancreas.	Zinc	200-202	solute carrier family 39 member 4	Sus scrofa	84-88
23168272-1	2013	The aim of the present study was to analyse the sequence variability of the porcine Zip4-like Zn transporter gene and the association of identified sequence variants with average daily gain, apparent Zn absorption, plasma Zn concentration and Zn concentration in the liver and pancreas.	Zinc	200-202	solute carrier family 39 member 4	Sus scrofa	84-88
23421923-7	2013	Metalation of human MT-2A is shown to be metal ion specific by comparing relative metal ion binding constants for Cd(2+) and Zn(2+).	Zinc	125-127	metallothionein 2A	Homo sapiens	20-25
23260180-7	2013	By contrast, higher H(2)O(2) and MDA contents in Zn-treated roots were correlated with the stimulation of SOD and the inhibition of POD and GR.	Zinc	49-51	peroxidase-like	Triticum aestivum	132-135
23345406-6	2013	Pharmacological inhibition of CALHM1 permeability using Ruthenium Red, Zn(2+), and Gd(3+), or expression of the CALHM1 N140A and W114A mutants, which are deficient in mediating Ca(2+) influx, prevented the effect of CALHM1 on the MEK, ERK, RSK and MSK signaling cascade, demonstrating that CALHM1 controlled this pathway via its channel properties.	Zinc	71-73	calcium homeostasis modulator 1	Mus musculus	30-36
23673847-5	2013	PC1 had a high loading for Mg, Cu, Zn, Al, and Fe; PC2 was related to N, K, and Mn; and PC3 and PC4 mainly represented P and Ca.	Zinc	35-37	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
23266931-5	2013	The molecular mechanism responsible for the insulin-like effects of Zn compounds involves the activation of several key components of the insulin signaling pathways, which include the extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3-K)/protein kinase B/Akt (PKB/Akt) pathways.	Zinc	68-70	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	239-268
23524874-0	2013	Electrochemiluminescence energy transfer-promoted ultrasensitive immunoassay using near-infrared-emitting CdSeTe/CdS/ZnS quantum dots and gold nanorods.	Zinc	117-120	CDP-diacylglycerol synthase 1	Homo sapiens	106-109
23524874-3	2013	Herein, we present a sensitive ECL-ET based immunosensor for the detection of tumor markers, using energy tunable CdSeTe/CdS/ZnS double shell quantum dots (QDs) and gold nanorods (GNRs) as the donor and acceptor, respectively.	Zinc	125-128	CDP-diacylglycerol synthase 1	Homo sapiens	114-117
22890879-8	2012	Interestingly, Zn upregulated the expressions of VASA and ITG b1 but downregulated PIWIL2 and OCT4.	Zinc	15-17	POU class 5 homeobox 1	Homo sapiens	94-98
22932891-7	2012	Conversely, Zn supplementation would decrease the numbers of eosinophils, neutrophils, and monocytes in BALF; suppress eotaxin and MCP-1 protein secretion; and increase lung IFN-gamma mRNA expression.	Zinc	12-14	C-C motif chemokine ligand 2	Rattus norvegicus	131-136
22884904-2	2012	The receptor is constitutively active and Zn(2+) is a physiological agonist of GPR39.	Zinc	42-44	G protein-coupled receptor 39	Homo sapiens	79-84
23067545-3	2012	And also, Zn stress led to the inhibition of cell-wall bound peroxidase.	Zinc	10-12	peroxidase-like	Triticum aestivum	61-71
23439614-5	2012	TIP does not coordinate to Fe(3+) and shows only weak affinity for Cu(2+) or Zn(2+), in stark contrast to deferasirox, which avidly binds all three metal ions.	Zinc	77-79	TOR signaling pathway regulator	Homo sapiens	0-3
23064315-4	2012	The aim of             this study was to determine the expression levels of selected miRNA and zinc(II)-related             genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in             comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II)             treatment.	Zinc	95-103	solute carrier family 39 member 1	Homo sapiens	131-136
23064315-4	2012	The aim of             this study was to determine the expression levels of selected miRNA and zinc(II)-related             genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in             comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II)             treatment.	Zinc	290-298	solute carrier family 39 member 1	Homo sapiens	131-136
22832069-0	2012	Structural basis behind the interaction of Zn2+ with the protein alpha-synuclein and the Abeta peptide: a comparative analysis.	Zinc	43-47	synuclein alpha	Homo sapiens	65-80
22832069-5	2012	By using NMR spectroscopy, we have addressed here unknown structural details related to the binding of Zn(2+) to the protein AS through the design of site-directed and domain truncated mutants of AS.	Zinc	103-105	synuclein alpha	Homo sapiens	125-127
22832069-5	2012	By using NMR spectroscopy, we have addressed here unknown structural details related to the binding of Zn(2+) to the protein AS through the design of site-directed and domain truncated mutants of AS.	Zinc	103-105	synuclein alpha	Homo sapiens	196-198
22832069-7	2012	Although the results of this study contribute to the understanding of the structural and molecular basis behind the acceleration of AS fibrillation mediated by Zn(2+), the low affinity that characterizes the interaction of Zn(2+) with AS contrasts strongly with the high-affinity features reported for the binding of this metal ion to other target proteins linked to human amylodosis such as Abeta peptide and the Islet Amyloid Polypeptide (IAPP), challenging the biological relevance of zinc interactions in the pathogenesis of PD.	Zinc	160-162	synuclein alpha	Homo sapiens	132-134
22820507-7	2012	The rise in Ca(2+)(i) induced by PIF and AngII was completely attenuated by the Zn(2+) chelator D-myo-inositol-1,2,6-triphosphate, and this was reversed by administration of exogenous Zn(2+).	Zinc	80-82	Pif	Mus musculus	33-36
11014343-10	2000	SSZ-induced cleavage of the U1-70K protein was inhibited by Zn2+ and by specific inhibitors of caspases 3 and 8, but not caspases 1 and 9.	Zinc	60-64	small nuclear ribonucleoprotein 70 (U1)	Mus musculus	28-34
22820507-7	2012	The rise in Ca(2+)(i) induced by PIF and AngII was completely attenuated by the Zn(2+) chelator D-myo-inositol-1,2,6-triphosphate, and this was reversed by administration of exogenous Zn(2+).	Zinc	184-186	Pif	Mus musculus	33-36
23089641-4	2012	Far-UV-CD and fluorescence spectroscopy revealed that Ca2+ and Mg2+ binding induces conformation change in hPLSCR4, exposing hydrophobic patches of the protein, and Ca2+ has more affinity than Mg2+ and Zn2+.	Zinc	202-206	phospholipid scramblase 4	Homo sapiens	107-114
10702365-8	2000	Studies in vitro showed that GRP78 bound tightly to affinity columns with Pb(2+) as the affinity ligand and bound weakly when either Zn(2+) or Ni(2+) replaced the Pb(2+).	Zinc	133-135	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	29-34
23393983-4	2012	The bioaugmentation of the ST3 consortium enhanced Fe accumulation by 247%, Ni by 231% and Zn by 223% in B. juncea as compared to control plants.	Zinc	91-93	Sulfotransferase 3	Drosophila melanogaster	27-30
10824681-8	2000	Zn2+ inhibited both GABA(A) and GABA(C) receptors.	Zinc	0-4	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	20-27
10824681-9	2000	GABA(C) receptors were more susceptible to Zn2+; the IC50 for the GABA(A) receptor was 67.4 microM and that for the GABA(C) receptor was 1.9 microM.	Zinc	43-47	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	66-73
10657263-6	2000	In contrast, ethanol inhibited insulin-induced activating phosphorylation of p42/p44 mitogen-activated protein kinases; these inhibitory ethanol effects were prevented by Zn(2+).	Zinc	171-173	interferon-induced protein 44	Mus musculus	81-84
22292746-1	2012	MMPs are a family of Zn dependent endopeptidases, which can mediate degradation of ECM components during various physiological and pathological processes including cancer.	Zinc	21-23	multimerin 1	Homo sapiens	83-86
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Zinc	311-317	solute carrier family 6 member 3	Homo sapiens	97-117
23120985-2	2012	It was established that Fe3+ in a form of free ion at concentration of 30 mg/l also stimulates both the reduction of chlorate by A. thermotoleranticus C-1 and the growth of biomass, Cd2+ Pb2+ and Mn2+ do not practically affect the process velocity or stimulate it a little, Cu2+ and Zn2+ lower the reduction rate of C10(3)- 2.5-3 times, under these conditions the biomass growth is inhibited more weakly than the reduction rate.	Zinc	283-287	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	151-154
10601246-2	1999	Recently, we have described a distance constraint in the unknown tertiary structure of the human dopamine transporter (hDAT) by identification of two histidines, His(193) in the second extracellular loop and His(375) at the top of transmembrane (TM) 7, that form two coordinates in an endogenous, high affinity Zn(2+)-binding site.	Zinc	311-317	solute carrier family 6 member 3	Homo sapiens	119-123
10601246-3	1999	To achieve further insight into the tertiary organization of hDAT, we set out to identify additional residues involved in Zn(2+) binding and subsequently to engineer artificial Zn(2+)-binding sites.	Zinc	122-128	solute carrier family 6 member 3	Homo sapiens	61-65
10601246-3	1999	To achieve further insight into the tertiary organization of hDAT, we set out to identify additional residues involved in Zn(2+) binding and subsequently to engineer artificial Zn(2+)-binding sites.	Zinc	177-183	solute carrier family 6 member 3	Homo sapiens	61-65
10601246-6	1999	These data suggest that Glu(396) is involved in Zn(2+) binding to hDAT.	Zinc	48-50	solute carrier family 6 member 3	Homo sapiens	66-70
10601246-8	1999	The common participation of Glu(396), His(193), and His(375) in binding the small Zn(2+) ion implies their proximity in the unknown tertiary structure of hDAT.	Zinc	82-84	solute carrier family 6 member 3	Homo sapiens	154-158
22736759-6	2012	Radiotracer and continuous measurement of transport by fluorescence assays revealed that DMT1 mediates the transport of several metal ions that were ranked in selectivity by using the ratio I(max)/K(0.5) (determined from evoked currents at -70 mV): Cd(2+) &gt; Fe(2+) &gt; Co(2+), Mn(2+) &gt;&gt; Zn(2+), Ni(2+), VO(2+).	Zinc	297-299	solute carrier family 11 member 2	Homo sapiens	89-93
10514432-7	1999	The binding of HRG to immunoglobulins containing the kappa L-chain (particularly IgG1kappa) was generally potentiated in the presence of a physiological concentration (20 microM) of Zn(2+) (K(d) decreased to 0.60 +/- 0.01 for IgG1kappa), but Zn(2+) had no effect or slightly inhibited the binding of HRG to immobilized IgG subclasses possessing the lambda L-chain.	Zinc	182-184	histidine rich glycoprotein	Homo sapiens	15-18
22822062-9	2012	TDP2 requires Mg(2+) or Mn(2+) for efficient catalysis but is weakly active with Ca(2+) or Zn(2+).	Zinc	91-93	tyrosyl-DNA phosphodiesterase 2	Homo sapiens	0-4
10514432-7	1999	The binding of HRG to immunoglobulins containing the kappa L-chain (particularly IgG1kappa) was generally potentiated in the presence of a physiological concentration (20 microM) of Zn(2+) (K(d) decreased to 0.60 +/- 0.01 for IgG1kappa), but Zn(2+) had no effect or slightly inhibited the binding of HRG to immobilized IgG subclasses possessing the lambda L-chain.	Zinc	182-184	histidine rich glycoprotein	Homo sapiens	300-303
10514432-7	1999	The binding of HRG to immunoglobulins containing the kappa L-chain (particularly IgG1kappa) was generally potentiated in the presence of a physiological concentration (20 microM) of Zn(2+) (K(d) decreased to 0.60 +/- 0.01 for IgG1kappa), but Zn(2+) had no effect or slightly inhibited the binding of HRG to immobilized IgG subclasses possessing the lambda L-chain.	Zinc	182-188	histidine rich glycoprotein	Homo sapiens	15-18
10514432-7	1999	The binding of HRG to immunoglobulins containing the kappa L-chain (particularly IgG1kappa) was generally potentiated in the presence of a physiological concentration (20 microM) of Zn(2+) (K(d) decreased to 0.60 +/- 0.01 for IgG1kappa), but Zn(2+) had no effect or slightly inhibited the binding of HRG to immobilized IgG subclasses possessing the lambda L-chain.	Zinc	182-188	histidine rich glycoprotein	Homo sapiens	300-303
10514432-8	1999	Interestingly, HRG also bound differentially to Bence Jones (BJ) proteins containing kappa and lambda L-chains, with HRG having a 14-fold lower K(d) for BJkappa than for BJlambda when 20 microM Zn(2+) was present.	Zinc	194-196	histidine rich glycoprotein	Homo sapiens	15-18
10514432-8	1999	Interestingly, HRG also bound differentially to Bence Jones (BJ) proteins containing kappa and lambda L-chains, with HRG having a 14-fold lower K(d) for BJkappa than for BJlambda when 20 microM Zn(2+) was present.	Zinc	194-196	histidine rich glycoprotein	Homo sapiens	117-120
10514432-9	1999	HRG also bound to IgM (IgMkappa), but the affinity of this interaction (K(d) approximately 1.99 +/- 0.05 microM) was markedly lower than the interaction with IgG, and the affinity was actually decreased 4-fold in the presence of Zn(2+).	Zinc	229-231	histidine rich glycoprotein	Homo sapiens	0-3
22465770-2	2012	X-ray diffraction (XRD) and transmission electron microscopy (TEM) techniques were used to characterize the uncoated and the novel ZnS:Mn(2+)/CdS core-shell nanoparticles.	Zinc	131-134	CDP-diacylglycerol synthase 1	Homo sapiens	142-145
22465770-3	2012	The results show that the size of the ZnS:Mn(2+)/CdS core-shell nanoparticles is less than the bare ZnS:Mn(2+).	Zinc	38-41	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
22465770-3	2012	The results show that the size of the ZnS:Mn(2+)/CdS core-shell nanoparticles is less than the bare ZnS:Mn(2+).	Zinc	100-103	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
22465770-4	2012	The PL study of ZnS:Mn(2+)/CdS core-shell nanoparticles shows an enhanced intensity than ZnS:Mn(2+).	Zinc	16-19	CDP-diacylglycerol synthase 1	Homo sapiens	27-30
22465770-4	2012	The PL study of ZnS:Mn(2+)/CdS core-shell nanoparticles shows an enhanced intensity than ZnS:Mn(2+).	Zinc	89-92	CDP-diacylglycerol synthase 1	Homo sapiens	27-30
22465770-7	2012	The presence of Mn(2+) ions in ZnS lattice and the growth of the CdS on ZnS:Mn(2+) nanoparticles were confirmed by the ESR spectra.	Zinc	72-75	CDP-diacylglycerol synthase 1	Homo sapiens	65-68
22684055-4	2012	ADAM-8 has an overall fold similar to those of other ADAM members, including a central five-stranded beta-sheet and a catalytic Zn(2+) ion.	Zinc	128-130	ADAM metallopeptidase domain 8	Homo sapiens	0-6
21906406-8	2012	The expression levels of the Zn transporters Zip4 and ZnT1 in the intestinal epithelium were significantly lower in rats fed a diet supplemented with 1016 mg/kg Zn compared to those fed the basal diet.	Zinc	29-31	solute carrier family 30 member 1	Rattus norvegicus	54-58
23565341-0	2012	Involvement of SIRT1 in Zn2+, Streptozotocin, Non-Obese Diabetic, and Cytokine-Mediated Toxicities of beta-cells.	Zinc	24-28	sirtuin 1	Mus musculus	15-20
23565341-5	2012	METHODS: Sensitivity of MIN6 cells expressing empty vector, sirtuin protein-1 (SIRT1) or its siRNA, to Zn2+, streptozotocin, or cytokines, and effects on NAD+ levels were determined.	Zinc	103-107	sirtuin 1	Mus musculus	60-77
23565341-5	2012	METHODS: Sensitivity of MIN6 cells expressing empty vector, sirtuin protein-1 (SIRT1) or its siRNA, to Zn2+, streptozotocin, or cytokines, and effects on NAD+ levels were determined.	Zinc	103-107	sirtuin 1	Mus musculus	79-84
22509818-9	2012	Surface passivation of CdS@MPA cores by a wider bandgap material, ZnS, led to enhanced luminescence intensity.	Zinc	66-69	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
22068728-7	2012	These results confirm that DMT1 is involved in active transport of Fe, Cu, and Zn although Zn showed a different relative capacity.	Zinc	91-93	solute carrier family 11 member 2	Homo sapiens	27-31
22068728-8	2012	These results also show that hCTR1 is able to transport Fe and Zn.	Zinc	63-65	solute carrier family 31 member 1	Homo sapiens	29-34
21939673-3	2012	Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.	Zinc	0-2	8-oxoguanine DNA glycosylase	Homo sapiens	137-141
22416042-5	2012	In the case of o-SLG, the addition of Cu(2+) and Mg(2+) ions maintained the gelating ability of the compound, whilst Zn(2+) and Ni(2+) ions destroyed the gel.	Zinc	117-119	sialic acid binding Ig like lectin 12	Homo sapiens	17-20
22344178-8	2012	Each pao(-) ligand adopts the eta(1) : eta(1) : eta(1) : mu coordination mode, chelating one Zn(II) atom and bridging a Zn(II)(2) pair.	Zinc	93-99	secreted phosphoprotein 1	Homo sapiens	30-36
22344178-8	2012	Each pao(-) ligand adopts the eta(1) : eta(1) : eta(1) : mu coordination mode, chelating one Zn(II) atom and bridging a Zn(II)(2) pair.	Zinc	93-99	secreted phosphoprotein 1	Homo sapiens	39-45
22344178-8	2012	Each pao(-) ligand adopts the eta(1) : eta(1) : eta(1) : mu coordination mode, chelating one Zn(II) atom and bridging a Zn(II)(2) pair.	Zinc	93-99	secreted phosphoprotein 1	Homo sapiens	39-45
22344178-8	2012	Each pao(-) ligand adopts the eta(1) : eta(1) : eta(1) : mu coordination mode, chelating one Zn(II) atom and bridging a Zn(II)(2) pair.	Zinc	120-126	secreted phosphoprotein 1	Homo sapiens	30-36
21702047-7	2012	Our data suggest that Zip5, Zip8, and Zip10 may be key to Zn acquisition from maternal circulation, while multiple Zip proteins reuptake Zn from milk.	Zinc	58-60	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	28-32
21702047-7	2012	Our data suggest that Zip5, Zip8, and Zip10 may be key to Zn acquisition from maternal circulation, while multiple Zip proteins reuptake Zn from milk.	Zinc	58-60	solute carrier family 39 (zinc transporter), member 3	Mus musculus	22-25
22282516-6	2012	The typical DNA-binding domain Zn(II)(2)-Cys(6) of Dal81 is unnecessary for its activity and Uga3 acts as a bridge between Dal81 and DNA.	Zinc	31-33	Dal81p	Saccharomyces cerevisiae S288C	51-56
22014117-6	2012	Detailed analysis showed clearly the correlation of AtMT4a and AtMT4b to the accumulation of some important metal ions in late embryos, especially to Zn ion storing in seeds, which then serves as part of early Zn ion resources for post-germinated seedling growth.	Zinc	150-152	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	63-69
22014117-6	2012	Detailed analysis showed clearly the correlation of AtMT4a and AtMT4b to the accumulation of some important metal ions in late embryos, especially to Zn ion storing in seeds, which then serves as part of early Zn ion resources for post-germinated seedling growth.	Zinc	210-212	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	63-69
22014117-7	2012	Furthermore, phytohormone abscisic acid (ABA) and gibberellic acid (GA) may play roles in regulating the expression and function of AtMT4a and AtMT4b during seed development; and this may influence Zn accumulation in seeds and Zn ion nutrient supplementation in the early seedling growth after germination.	Zinc	198-200	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	143-149
22014117-7	2012	Furthermore, phytohormone abscisic acid (ABA) and gibberellic acid (GA) may play roles in regulating the expression and function of AtMT4a and AtMT4b during seed development; and this may influence Zn accumulation in seeds and Zn ion nutrient supplementation in the early seedling growth after germination.	Zinc	227-229	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	143-149
22066515-6	2012	Blocking glutathione biosynthesis in wild-type plants by a specific inhibitor of GSH1, buthionine sulfoximine, resulted in loss of Fe-mediated Zn tolerance, which provides further evidence that glutathione plays an essential role in Fe-mediated Zn tolerance.	Zinc	143-145	glutamate-cysteine ligase	Arabidopsis thaliana	81-85
10461992-1	1999	Dietary phytase supplementation improves bioavailabilities of phytate-bound minerals such as P, Ca, and Zn to pigs, but its effect on Fe utilization is not clear.	Zinc	104-106	putative glycerophosphoryl diester phosphodiesterase	Glycine max	8-15
10358054-4	1999	Now we report engineering of metal-binding sites bridging the cytoplasmic ends of these two helices in two other serpentine receptors, the beta2-adrenoreceptor and the parathyroid hormone receptor; occupancy of the metal-binding site by Zn(II) markedly impairs the ability of each receptor to mediate ligand-dependent activation of Gs, the stimulatory regulator of adenylyl cyclase.	Zinc	237-239	adrenoceptor beta 2	Homo sapiens	139-159
10501564-2	1999	While prior studies using the slowly desensitizing agonist kainate suggested preferential Zn2+ permeation through Ca2+ permeable AMPA/kainate (Ca-A/K) channels, the present study aims to assess relevance of those findings upon more physiological receptor activation.	Zinc	90-94	teashirt zinc finger homeobox 1	Homo sapiens	143-149
10411640-13	1999	hK2 is inhibited by Zn2+ at micromolar concentrations well below the 9 mM zinc concentration found in the prostate.	Zinc	20-24	RBPJ pseudogene 3	Homo sapiens	0-3
10411640-14	1999	The enzymatic activity of hK2 is likely to be reversibly regulated by Zn2+ in prostatic fluid.	Zinc	70-74	RBPJ pseudogene 3	Homo sapiens	26-29
10346818-4	1999	By replacing the carboxy-terminal TRAF domain of TRAF2 and TRAF6 with repeats of the immunophilin FKBP12, we demonstrate that their effector domains are composed of their amino-terminal Zn and RING fingers.	Zinc	186-188	TNF receptor associated factor 2	Homo sapiens	49-54
10216093-2	1999	Here, we demonstrate that Zn2+ can induce the adhesion of myelomonocytic cells to the endothelium, as well as to the provisional matrix proteins vitronectin (VN) and fibrinogen (FBG), which are pivotal steps for the recruitment of leukocytes into inflamed/injured tissue.	Zinc	26-30	vitronectin	Homo sapiens	145-156
10216093-2	1999	Here, we demonstrate that Zn2+ can induce the adhesion of myelomonocytic cells to the endothelium, as well as to the provisional matrix proteins vitronectin (VN) and fibrinogen (FBG), which are pivotal steps for the recruitment of leukocytes into inflamed/injured tissue.	Zinc	26-30	vitronectin	Homo sapiens	158-160
10216093-3	1999	Physiologic concentrations of Zn2+ increased the urokinase receptor (uPAR)-mediated adhesion of myelomonocytic cells to VN, whereas other divalent cations had smaller effects.	Zinc	30-34	vitronectin	Homo sapiens	120-122
10216093-4	1999	Zn2+-induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline, as well as by plasminogen activator inhibitor-1 (PAI-1) and a monoclonal antibody (MoAb) against uPAR.	Zinc	0-4	vitronectin	Homo sapiens	30-32
10216093-6	1999	Like urokinase (uPA), Zn2+ increased the binding of radiolabeled VN to uPAR-expressing cells, as well as the interaction of VN with immobilized uPAR in an isolated system.	Zinc	22-26	vitronectin	Homo sapiens	65-67
10341316-6	1999	Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn-induced immunostimulation.	Zinc	206-208	LOC105243590	Mus musculus	51-55
10341316-6	1999	Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn-induced immunostimulation.	Zinc	206-208	CD4 antigen	Mus musculus	105-108
10188989-6	1999	Zn2+ (100 nM - 10 microM) potentiated ATP-responses at the rP2X4 receptor by 2 fold, whereas higher concentrations (30 microM - 1 mM) inhibited ATP-responses.	Zinc	0-4	purinergic receptor P2X 4	Rattus norvegicus	59-64
10188989-13	1999	In conclusion, H+ and Zn2+ exerted opposite effects on the rP2X4 receptor by lowering and raising agonist potency, respectively.	Zinc	22-26	purinergic receptor P2X 4	Rattus norvegicus	59-64
10188989-14	1999	H+ (&gt; or = 3 microM) and Zn2+ (&gt; or = 30 microM) also reduces agonist efficacy by lowering the number of rP2X4 receptors available for activation.	Zinc	28-32	purinergic receptor P2X 4	Rattus norvegicus	111-116
10188989-15	1999	The striking differences between the modulatory actions of H+ and Zn2+ at rP2X4 and rP2X2 receptors are discussed.	Zinc	66-70	purinergic receptor P2X 4	Rattus norvegicus	74-79
10188989-15	1999	The striking differences between the modulatory actions of H+ and Zn2+ at rP2X4 and rP2X2 receptors are discussed.	Zinc	66-70	purinergic receptor P2X 2	Rattus norvegicus	84-89
9987035-7	1999	Pretreatment with insulin or brain-derived neurotrophic factor increased the Zn(2+)-induced free radical injury.	Zinc	77-83	brain derived neurotrophic factor	Homo sapiens	29-62
10575295-4	1999	Since until now MT-0 protein was only found in human fetal liver and in Zn-stimulated human monocytes, a possible role for this isoform as an oncofetal marker is hypothesized.	Zinc	72-74	metallothionein 1H	Homo sapiens	16-20
9929559-5	1999	The effects of Cd2+ on the twitch, tetanus and action potential were mimicked by Zn2+, while La3+ and Co2+ at 3 mM - or Mg2+ and Ca2+ at 30 mM - depressed peak twitch and tetanic tension, but did not potentiate twitches.	Zinc	81-85	Cd2 molecule	Rattus norvegicus	15-18
9929559-6	1999	The results suggest that: (1) Cd2+ and Zn2+ potentiate twitch tension by prolonging action potential depolarisation; (2) Cd2+ depresses twitch and tetanic tension by reducing the action potential overshoot, and causing a positive shift in the voltage dependence of contraction; and (3) the irreversible depression of action potential amplitude in rat soleus muscle is a specific property of Cd2+ and Zn2+ that is not shared by Co2+, Mg2+ or Ca2+.	Zinc	400-404	Cd2 molecule	Rattus norvegicus	121-124
9929559-6	1999	The results suggest that: (1) Cd2+ and Zn2+ potentiate twitch tension by prolonging action potential depolarisation; (2) Cd2+ depresses twitch and tetanic tension by reducing the action potential overshoot, and causing a positive shift in the voltage dependence of contraction; and (3) the irreversible depression of action potential amplitude in rat soleus muscle is a specific property of Cd2+ and Zn2+ that is not shared by Co2+, Mg2+ or Ca2+.	Zinc	400-404	Cd2 molecule	Rattus norvegicus	121-124
9830036-4	1998	In an in vitro binding reaction, Zn2+ mediates p56(lck) association with a glutathione S-transferase (GST) fusion protein containing the cytosolic domains of CD4 or CD8alpha; no other metals tested support binding.	Zinc	33-37	CD8a molecule	Homo sapiens	165-173
9836590-0	1998	Aggregation behaviour and Zn2+ binding properties of secretin.	Zinc	26-30	secretin	Homo sapiens	53-61
9836590-10	1998	The potential for secretin to bind divalent cations, including Ca2+ and Zn2+, was also examined by CD1 and NMR spectroscopy.	Zinc	72-76	secretin	Homo sapiens	18-26
9836590-11	1998	The results revealed that Zn2+ specifically coordinates to the His1 and Asp3 residues of each secretin monomer without disrupting the peptide"s helical structure, whereas Ca2+ did not exhibit any interaction with the peptide hormone.	Zinc	26-30	secretin	Homo sapiens	94-102
9836595-1	1998	The hdm2 oncoprotein contains a C-terminal domain that binds RNA and has been suggested to bind zinc(II) in an unusual RING finger domain in which Thr 455 was postulated as a ligand.	Zinc	96-104	MDM2 proto-oncogene	Homo sapiens	4-8
9834141-1	1998	Extracellular Zn2+ was found to reversibly inhibit the ClC-0 Cl- channel.	Zinc	14-18	Charcot-Leyden crystal galectin	Homo sapiens	55-58
9834141-2	1998	The apparent on and off rates of the inhibition were highly temperature sensitive, suggesting an effect of Zn2+ on the slow gating (or inactivation) of ClC-0.	Zinc	107-111	Charcot-Leyden crystal galectin	Homo sapiens	152-155
9834141-6	1998	When ClC-0 is bound with Zn2+, the equilibrium constant of the slow-gating process is increased by approximately 30-fold, reflecting a 30-fold higher Zn2+ affinity in the inactivated channel than in the open-state channel.	Zinc	25-29	Charcot-Leyden crystal galectin	Homo sapiens	5-8
22066515-6	2012	Blocking glutathione biosynthesis in wild-type plants by a specific inhibitor of GSH1, buthionine sulfoximine, resulted in loss of Fe-mediated Zn tolerance, which provides further evidence that glutathione plays an essential role in Fe-mediated Zn tolerance.	Zinc	245-247	glutamate-cysteine ligase	Arabidopsis thaliana	81-85
22066515-7	2012	Two glutathione-deficient mutant alleles of GSH1, pad2-1 and cad2-1, which contain 22% and 39%, respectively, of the wild-type glutathione level, revealed that a minimal glutathione level between 22 and 39% of the wild-type level is required for Fe-mediated Zn tolerance.	Zinc	258-260	glutamate-cysteine ligase	Arabidopsis thaliana	44-48
9834141-6	1998	When ClC-0 is bound with Zn2+, the equilibrium constant of the slow-gating process is increased by approximately 30-fold, reflecting a 30-fold higher Zn2+ affinity in the inactivated channel than in the open-state channel.	Zinc	150-154	Charcot-Leyden crystal galectin	Homo sapiens	5-8
22317921-2	2012	Zinc channels of the ZIP (ZRT1- and IRT1-like protein) family [also known as solute carrier family 39A (SLC39A)] transiently increase the cytosolic free zinc (Zn(2+)) concentration in response to extracellular signals.	Zinc	159-165	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	21-24
9834141-12	1998	These results together indicate that extracellular Zn2+ inhibits ClC-0 by facilitating the slow-gating process.	Zinc	51-55	Charcot-Leyden crystal galectin	Homo sapiens	65-68
22317921-2	2012	Zinc channels of the ZIP (ZRT1- and IRT1-like protein) family [also known as solute carrier family 39A (SLC39A)] transiently increase the cytosolic free zinc (Zn(2+)) concentration in response to extracellular signals.	Zinc	159-165	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	26-53
9611199-3	1998	This identified recessive mutations in MOT3, which encodes a nuclear protein with two Cys2-His2 Zn fingers.	Zinc	96-98	Mot3p	Saccharomyces cerevisiae S288C	39-43
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Zinc	174-176	zinc transporter	Arabidopsis thaliana	21-27
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Zinc	174-176	zinc transporter	Arabidopsis thaliana	90-96
22139846-7	2012	Furthermore, mutants of AtMTP1 generated through random mutagenesis revealed residues embedded within transmembrane domain 3 that additionally specify the high degree of Zn(2+) selectivity.	Zinc	170-172	zinc transporter	Arabidopsis thaliana	24-30
22349685-2	2012	Zn2+ can accelerate assembly of the amyloid-beta peptides (Abeta) and tau protein central to the neuropathological changes found in Alzheimer"s disease (AD).	Zinc	0-4	microtubule associated protein tau	Homo sapiens	70-73
22349685-10	2012	These expression changes could either reflect or cause the altered cortical Zn2+ distribution in AD, potentially increasing the likelihood of interactions between Zn2+ and Abeta or tau protein.	Zinc	76-80	microtubule associated protein tau	Homo sapiens	181-184
22570624-2	2012	Considerable in vitro evidence indicates that the aggregation/oligomerization of Abeta is promoted in the presence of Zn; however, the functional role of Zn in AD pathogenesis is still not well clarified in vivo.	Zinc	118-120	beta amyloid protein precursor-like	Drosophila melanogaster	81-86
9657286-13	1998	In the kidney of Vit A + Ni treated mice, the increase of Cu, Fe, and Zn but not Ca, was reduced and not significantly different from control and Vit A-treated mice.	Zinc	70-72	vitrin	Mus musculus	17-20
9657286-14	1998	Pretreatment with Vit A reduced the increased Fe, Cu, Zn and Ca concentration in the lung caused by Ni injection.	Zinc	54-56	vitrin	Mus musculus	18-21
9504955-7	1998	Covariant analyses showed that serum ALP, tibial ALP, tibial protein, and tibial TRAP were affected by the dose of Zn (P &lt; 0.005) and by the treatment time (P &lt; 0.03).	Zinc	115-117	acid phosphatase 5, tartrate resistant	Mus musculus	81-85
9504955-9	1998	The second dietary study confirmed the results of the first: 4 weeks of treatment with Zn caused significant increases in serum ALP, calvarial ALP, and tibial ALP activities, and a significant decrease in tibial TRAP (P &lt; 0.05-0.005 for each).	Zinc	87-89	acid phosphatase 5, tartrate resistant	Mus musculus	212-216
9504955-12	1998	The effect of Zn to decrease TRAP activity in osteoblast-line cells precludes the interpretation of a Zn-dependent decrease in tibial TRAP activity as evidence of decreased bone resorption.	Zinc	14-16	acid phosphatase 5, tartrate resistant	Mus musculus	29-33
9504955-12	1998	The effect of Zn to decrease TRAP activity in osteoblast-line cells precludes the interpretation of a Zn-dependent decrease in tibial TRAP activity as evidence of decreased bone resorption.	Zinc	102-104	acid phosphatase 5, tartrate resistant	Mus musculus	134-138
22570624-2	2012	Considerable in vitro evidence indicates that the aggregation/oligomerization of Abeta is promoted in the presence of Zn; however, the functional role of Zn in AD pathogenesis is still not well clarified in vivo.	Zinc	154-156	beta amyloid protein precursor-like	Drosophila melanogaster	81-86
22570624-4	2012	Using a genetically tractable Drosophila model, we found that the expression of dZip1, the orthologue of human Slc39 family transporter hZip1 in Drosophila, was altered in the brains of Abeta42-expressing flies, and Zn homeostasis could be modulated by forcible dZip1 expression changes.	Zinc	216-218	Zinc/iron regulated transporter-related protein 42C.1	Drosophila melanogaster	80-85
22570624-4	2012	Using a genetically tractable Drosophila model, we found that the expression of dZip1, the orthologue of human Slc39 family transporter hZip1 in Drosophila, was altered in the brains of Abeta42-expressing flies, and Zn homeostasis could be modulated by forcible dZip1 expression changes.	Zinc	216-218	solute carrier family 39 member 1	Homo sapiens	136-141
22545109-5	2012	Silencing of the G-protein coupled receptor GPR39 expression abolished ZnR-dependent Ca(2+) release and Zn(2+)-dependent survival of butyrate-treated colonocytes.	Zinc	104-110	G protein-coupled receptor 39	Homo sapiens	44-49
18967008-5	1997	The selectivity of silica-ERT phase towards the extraction of a certain metal ion from a mixture containing only two metal ions is studied by the batch equilibrium technique and exhibited good discrimination orders for Zn(II) and Mg(II) in presence of Ca(II).	Zinc	219-225	carbonic anhydrase 2	Homo sapiens	252-258
9434104-5	1997	Tyrosine 17 fluorescence spectra showed a decrease of intensity upon binding of Ca2+ to the three proteins and an increase upon binding of Zn2+ to rS100beta and NoEF but not in Caloops.	Zinc	139-143	S100 calcium binding protein B	Rattus norvegicus	147-156
9263330-7	1997	Reconstitution experiments of the human enzyme indicate that TRP2 has Zn at its metal binding-sites.	Zinc	70-72	dopachrome tautomerase	Homo sapiens	61-65
9168122-6	1997	The crude enzyme prepared from the periplasmic fraction of recombinant E. coli was inhibited by a metalloprotease inhibitor and Zn2+ is essential for its protease activity.	Zinc	128-132	metalloprotease	Escherichia coli	98-113
9126286-3	1997	Expression of I-FABP in all transfected cell lines tested was induced several-fold by optimized levels of Cd2+ and Zn2+.	Zinc	115-119	fatty acid binding protein 2	Rattus norvegicus	14-20
9126286-10	1997	Therefore, promoter induction levels of Cd2+ and Zn2+ enhanced I-FABP expression in H141 cells, thereby modulating both fatty acid uptake and intracellular esterification into neutral and phospholipids.	Zinc	49-53	fatty acid binding protein 2	Rattus norvegicus	63-69
9204381-3	1997	Excellent inhibition of three CA isozymes (CA I, II and IV respectively) were observed with some of the new sulfonamides, but especially with their Zn(II) complexes.	Zinc	148-154	carbonic anhydrase 1	Homo sapiens	43-47
9016620-9	1997	The protein exhibited no DNase activity in the presence of Zn2+ion, which was one of the most preferable divalent cations for ATPase activity.	Zinc	59-63	AAA family ATPase	Thermococcus kodakarensis KOD1	126-132
8807898-0	1996	A Zn(II)-binding site engineered into retinol-binding protein exhibits metal-ion specificity and allows highly efficient affinity purification with a newly designed metal ligand.	Zinc	2-8	retinol binding protein 4	Homo sapiens	38-61
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Zinc	16-22	carbonic anhydrase 2	Homo sapiens	68-89
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Zinc	16-22	retinol binding protein 4	Homo sapiens	166-189
8807898-1	1996	BACKGROUND: The Zn(II)-binding site from the active center of human carbonic anhydrase II, formed by three His side chains, can be grafted onto the recombinant serum retinol-binding protein (RBP).	Zinc	16-22	retinol binding protein 4	Homo sapiens	191-194
8807898-2	1996	The artificial binding site in the resulting variant RBP/H3(A) has high affinity for Zn(II) and stabilizes the protein against denaturation.	Zinc	85-87	retinol binding protein 4	Homo sapiens	53-56
8807898-3	1996	RESULTS: The metal-ion specificity of the grafted Zn(II) binding site in RBP/H3(A) was investigated.	Zinc	50-56	retinol binding protein 4	Homo sapiens	73-76
8631882-7	1996	With Zn2+ stimulation of furin expression, the messages of PC2, PC3, and chromogranin A decreased, and the processing of proinsulin to mature insulin became less efficient.	Zinc	5-9	proprotein convertase subtilisin/kexin type 1	Mus musculus	64-67
8631882-7	1996	With Zn2+ stimulation of furin expression, the messages of PC2, PC3, and chromogranin A decreased, and the processing of proinsulin to mature insulin became less efficient.	Zinc	5-9	chromogranin A	Mus musculus	73-87
8626461-3	1996	Here, this Zn(II) site is transferred to the kappa-opioid receptor by substituting two residues at the outer portion of transmembrane V (TM-V), Asp223 and Lys227, and one residue at the top of TM-VI, Ala298, with histidyl residues.	Zinc	11-17	opioid receptor kappa 1	Homo sapiens	45-66
8639494-9	1996	These novel properties engineered into E117Q CAII facilitate the exploitation of CAII as a rapid and sensitive Zn(2+) biosensor.	Zinc	111-117	carbonic anhydrase 2	Homo sapiens	45-49
8639494-9	1996	These novel properties engineered into E117Q CAII facilitate the exploitation of CAII as a rapid and sensitive Zn(2+) biosensor.	Zinc	111-117	carbonic anhydrase 2	Homo sapiens	81-85
8592145-5	1996	In the present study, we investigate the effect of Zn2+ on aggregation of radiolabeled and unlabeled human and rat A beta over a wide range of peptide concentrations in the presence and absence of salt and blocking protein.	Zinc	51-55	amyloid beta precursor protein	Rattus norvegicus	115-121
8964254-3	1995	In the case of ALA-D or Zn-reactivated ALA-D despite the direct correlation with BLL, the curve follows a potential or a logarithmic line, which is not the best to calculate BLL.	Zinc	24-26	aminolevulinate dehydratase	Homo sapiens	39-44
8964254-4	1995	The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D.	Zinc	14-16	aminolevulinate dehydratase	Homo sapiens	17-22
8964254-4	1995	The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D.	Zinc	14-16	aminolevulinate dehydratase	Homo sapiens	117-122
8964254-4	1995	The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D.	Zinc	14-16	aminolevulinate dehydratase	Homo sapiens	117-122
8597881-13	1995	A small stimulation of 12% above Zn+Dex was obtained with leukaemia inhibitory factor (LIF) at concentrations greater than 100 U/mL.	Zinc	33-35	LIF, interleukin 6 family cytokine	Rattus norvegicus	58-85
8597881-13	1995	A small stimulation of 12% above Zn+Dex was obtained with leukaemia inhibitory factor (LIF) at concentrations greater than 100 U/mL.	Zinc	33-35	LIF, interleukin 6 family cytokine	Rattus norvegicus	87-90
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	35-37	metallothionein 1I, pseudogene	Homo sapiens	61-64
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	35-37	metallothionein 2A	Homo sapiens	66-69
7592604-17	1995	This is consistent with a role for one or both of these histidines as a ligand to the required Zn(II) of E. coli PBGS, which is known to participate in substrate binding.	Zinc	95-97	aminolevulinate dehydratase	Homo sapiens	113-117
7592604-18	1995	Past chemical modification may have inactivated the PBGS by blocking Zn(II) and ALA binding.	Zinc	69-75	aminolevulinate dehydratase	Homo sapiens	52-56
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	133-139	metallothionein 1I, pseudogene	Homo sapiens	61-64
8582785-11	1995	The inhibiting effect of Zn2+ on apoptosis is related to an increase in the number of CD4+CD8+ thymocytes.	Zinc	25-29	CD4 antigen	Mus musculus	86-89
8582785-12	1995	Concentrations of Zn2+ inducing apoptosis sometimes cause a decrease of CD4+CD8+ cells with a corresponding increase of CD4+CD8-thymocytes.	Zinc	18-22	CD4 antigen	Mus musculus	72-75
8582785-12	1995	Concentrations of Zn2+ inducing apoptosis sometimes cause a decrease of CD4+CD8+ cells with a corresponding increase of CD4+CD8-thymocytes.	Zinc	18-22	CD4 antigen	Mus musculus	120-123
7603033-3	1995	Zn2+ can affect intracellular Ca2+ homeostasis, so the aim of this study was to investigate whether TPEN-induced apoptosis is mediated by Ca2+ signalling.	Zinc	0-4	carbonic anhydrase 2	Homo sapiens	30-33
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	133-139	metallothionein 2A	Homo sapiens	66-69
21678079-4	2011	Particular attention is paid to the Tg2576 Alzheimer disease mouse model and the preliminary results obtained in mice into which human Zn(7)MT-2A was injected, which suggest a reversal of the behavioral deficits while enhancing amyloid plaque load and gliosis.	Zinc	135-138	metallothionein 2A	Homo sapiens	140-145
9049347-5	1995	NS3 protease activity was inhibited by Cu2+ but was slightly enhanced by Zn2+.	Zinc	73-77	KRAS proto-oncogene, GTPase	Homo sapiens	0-3
7860645-2	1995	We found that in several types of cultured cells and in mice, Zn++ caused marked accumulation of c-fos mRNA and that of another labile mRNA, that encoding the tristetraprolin (TTP) protein.	Zinc	62-66	zinc finger protein 36	Mus musculus	159-174
7860645-2	1995	We found that in several types of cultured cells and in mice, Zn++ caused marked accumulation of c-fos mRNA and that of another labile mRNA, that encoding the tristetraprolin (TTP) protein.	Zinc	62-66	zinc finger protein 36	Mus musculus	176-179
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	31-35	zinc finger protein 36	Mus musculus	94-97
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	31-35	zinc finger protein 36	Mus musculus	212-215
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	160-164	zinc finger protein 36	Mus musculus	94-97
21688177-1	2011	The metallothionein (MT) superfamily combines a large variety of small cysteine-rich proteins from nearly all phyla of life that have the ability to coordinate various transition metal ions, including Zn(II), Cd(II), and Cu(I).	Zinc	201-207	metallothionein-like protein 1	Triticum aestivum	4-19
7860645-4	1995	When the cells were exposed to Zn++ for 4 h and then exposed to actinomycin D, both c-fos and TTP mRNA levels remained constant for up to 10 h, indicating that Zn++ was preventing the breakdown of both c-fos and TTP mRNA.	Zinc	160-164	zinc finger protein 36	Mus musculus	212-215
7860645-6	1995	Zn++ was unable to inhibit the breakdown of TTP and c-fos mRNA in vitro; however, extracts from cells exposed to Zn++ were less able to cause the breakdown of TTP and c-fos mRNAs than were extracts from control cells, again suggesting that Zn++ indirectly affects mRNA stability through inhibition of protein synthesis.	Zinc	113-117	zinc finger protein 36	Mus musculus	159-162
7860645-6	1995	Zn++ was unable to inhibit the breakdown of TTP and c-fos mRNA in vitro; however, extracts from cells exposed to Zn++ were less able to cause the breakdown of TTP and c-fos mRNAs than were extracts from control cells, again suggesting that Zn++ indirectly affects mRNA stability through inhibition of protein synthesis.	Zinc	113-117	zinc finger protein 36	Mus musculus	159-162
7862134-4	1995	Thus, the binuclear Zn clusters of GAL4, the helix-loop-helix/basic domains of USF, and the rel domain of NF-kappa B all participated in cooperative nucleosome binding, illustrating that this effect is not restricted to a particular DNA-binding domain.	Zinc	20-22	galectin 4	Homo sapiens	35-39
21688177-1	2011	The metallothionein (MT) superfamily combines a large variety of small cysteine-rich proteins from nearly all phyla of life that have the ability to coordinate various transition metal ions, including Zn(II), Cd(II), and Cu(I).	Zinc	201-207	metallothionein-like protein 1	Triticum aestivum	21-23
21784112-4	2011	When Cu(2+) and Zn(2+) are added to SA and alpha-syn, protein aggregation is induced.	Zinc	16-22	synuclein alpha	Homo sapiens	43-52
7600450-3	1995	The KD for the half-maximal shift of the activation curve was 278 microM for Cd2+ and 93 microM for Zn2+; the maximal shifts of the activation curve were 32.5 and 34 mV, for Cd2+ and Zn2+, respectively.	Zinc	100-104	Cd2 molecule	Rattus norvegicus	174-177
7600450-3	1995	The KD for the half-maximal shift of the activation curve was 278 microM for Cd2+ and 93 microM for Zn2+; the maximal shifts of the activation curve were 32.5 and 34 mV, for Cd2+ and Zn2+, respectively.	Zinc	183-187	Cd2 molecule	Rattus norvegicus	77-80
21784112-5	2011	In the case of Zn(2+), the aggregation of alpha-syn increased to 74% (ratio=1:1000:50).	Zinc	15-17	synuclein alpha	Homo sapiens	42-51
21784112-8	2011	Thus, possible protective or inducing effects of lys, Cu(2+) and Zn(2+) may exist with alpha-syn.	Zinc	65-67	synuclein alpha	Homo sapiens	87-96
21900570-4	2011	As KCC2 is the major Cl(-) outward transporter in neurons, Zn(2+) also triggers a pronounced hyperpolarizing shift in the GABA(A) reversal potential.	Zinc	59-65	solute carrier family 12, member 5	Mus musculus	3-7
7775392-8	1995	Cu2+, Zn2+, or Cd2+ strongly inhibited rMME activity with IC50 values between 68 and 180 microM, while Mg2+, Ba2+, Mn2+, Co2+, and Sr2+ had no effect.	Zinc	6-10	membrane metallo-endopeptidase	Rattus norvegicus	39-43
21900570-5	2011	Mossy fiber stimulation-dependent upregulation of KCC2 activity is eliminated in slices from Zn(2+) transporter 3-deficient animals, which lack synaptic Zn(2+).	Zinc	93-95	solute carrier family 12, member 5	Mus musculus	50-54
21756885-5	2011	The co-exposure of fish to Cd and Zn abolished ZnT1 down-regulation and rendered a persistently increased ZIP10 mRNA level.	Zinc	34-36	solute carrier family 39 member 10	Danio rerio	106-111
7775392-9	1995	The requirement of Zn2+ for rMME activity was determined.	Zinc	19-23	membrane metallo-endopeptidase	Rattus norvegicus	28-32
7775392-12	1995	The optimal Zn2+ concentration for rMME activation was 100 microM.	Zinc	12-16	membrane metallo-endopeptidase	Rattus norvegicus	35-39
21652531-8	2011	The two transporter genes have a lower basal transcript expression in B. juncea seedling tissues when grown in normal conditions than under metal-stress, however, their transcripts levels could be substantially increased by Zn, Cd, NaCl or PEG, suggesting that BjCET3 and BjCET4 may play roles in several stress conditions, roles which appear to be different from those of previous characterized cation-efflux transporters, for example, AtMTP1, BjCET2, and BjMTP1.	Zinc	224-226	zinc transporter	Arabidopsis thaliana	437-443
7775392-13	1995	These results indicate that Zn2+ is tightly bound to rMME.	Zinc	28-32	membrane metallo-endopeptidase	Rattus norvegicus	53-57
7753753-8	1995	Cd2+ and Zn2+ were potent inhibitors of both binding sites, Cd2+ particularly of rem2 binding and Zn2+ preferably of rem1 binding.	Zinc	9-13	RRAD and GEM like GTPase 1	Rattus norvegicus	117-121
21658371-2	2011	ZIP8 functions endogenously as a electroneutral Zn(2+)/(HCO(3)(-))(2) symporter, moving both ions into the cell.	Zinc	48-50	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-4
7696990-0	1994	Dephosphorylation of ribosomal protein S6 phosphorylated via the cAMP-mediated signaling pathway in rat parotid gland: effect of okadaic acid and Zn2+.	Zinc	146-150	ribosomal protein S6	Rattus norvegicus	21-41
8200454-8	1994	Both bovine Cu1Cd5- and the equine Cu3Cd3-GIF derivatives (Cd replacing Zn) exhibit cadmium-dependent absorption and CD features between 220-260 nm characteristic of Cd-thiolate clusters similar to those in Cd-MTs.	Zinc	72-74	cobalamin binding intrinsic factor	Rattus norvegicus	42-45
8106444-8	1994	Zn(2+)-induced overexpression of PKC-delta- and PKC-epsilon-stimulated sodium-dependent phosphate uptake.	Zinc	0-2	protein kinase C, delta	Mus musculus	33-42
17180023-2	1994	In the experimental system we used, that is HeLa cells treated with VP-16, the protection from internucleosomal DNA degradation is modulated by Zn concentration and appears to be dependent on the time after treatment.	Zinc	144-146	host cell factor C1	Homo sapiens	68-73
8137886-4	1994	Zn2+ (3 microM) reduced the inhibitory potency of Cd2+ on the binding but was ineffective against CH3Hg+ and Cu2+.	Zinc	0-4	Cd2 molecule	Rattus norvegicus	50-53
8259647-5	1994	p28 was expressed in bacteria and shown to bind Zn in vitro.	Zinc	48-50	golgi SNAP receptor complex member 1	Homo sapiens	0-3
8303711-5	1993	A similar reduction was also observed when Zn,Cd-MT was administered during the development of an anti-sheep red blood cell (sRBC) humoral response.	Zinc	43-45	CYLD lysine 63 deubiquitinase	Homo sapiens	46-51
8303711-6	1993	When amounts of Zn and Cd equimolar to that associated with the Zn, Cd-MT were co-injected with OVA, humoral responsiveness was enhanced, in contrast to the suppression seen with Zn, Cd-MT.	Zinc	16-18	CYLD lysine 63 deubiquitinase	Homo sapiens	68-73
8358292-10	1993	When Zn is added as a substrate for the terminal enzyme, ferrochelatase, along with coproporphyrinogen, there is formation of Zn protoporphyrin with little accumulation of free protoporphyrin.	Zinc	5-7	ferrochelatase	Mus musculus	57-71
8100148-1	1993	Recombinant human tyrosine hydroxylase has been purified as a metal-free apoenzyme (apo-hTH1) which tightly binds one Fe2+, Co2+, or Zn2+ per subunit with activation only by Fe2+ and competitive inhibition by the other cations.	Zinc	133-137	negative elongation factor complex member C/D	Homo sapiens	88-92
1473156-0	1992	Activation of apoalkaline phosphatase by serum albumin with Zn2+ in rat hepatoma cells.	Zinc	60-64	albumin	Rattus norvegicus	41-54
1473156-4	1992	In contrast, no effect from serum albumin was observed in the increase of alkaline phosphatase activity in R-Y121B cell homogenates incubated at 37 degrees C. The activated-charcoal treatment of bovine serum albumin increased the amount of Zn2+ bound to the protein.	Zinc	240-244	albumin	Rattus norvegicus	202-215
1473156-5	1992	When R-Y121B cells were cultured with bovine serum albumin, the concentration of Zn2+ in the cytosol fraction slightly increased.	Zinc	81-85	albumin	Rattus norvegicus	45-58
1473156-6	1992	However, the effect of serum albumin on Zn2+ concentration in the cytosol fractions was independent of charcoal treatment.	Zinc	40-44	albumin	Rattus norvegicus	23-36
1473156-7	1992	It was concluded that serum albumin with Zn2+ induces the activation of apoalkaline phosphatase due to Zn2+ binding.	Zinc	41-45	albumin	Rattus norvegicus	22-35
1473156-7	1992	It was concluded that serum albumin with Zn2+ induces the activation of apoalkaline phosphatase due to Zn2+ binding.	Zinc	103-107	albumin	Rattus norvegicus	22-35
1633158-5	1992	The salt sensitivity of the interaction indicated that two ion pairs are involved in the association of Zn2+ (NC-F1) with polynucleotide, whereas one ion pair is found in the metal-free peptide-nucleic acid complex.	Zinc	104-108	neutrophil cytosolic factor 1	Homo sapiens	110-115
1633158-7	1992	Using NMR methods, we monitored the binding of a synthetic oligonucleotide, d(TTTGGTTT), to Zn(NC-F1).	Zinc	92-94	neutrophil cytosolic factor 1	Homo sapiens	95-100
1348524-3	1992	These antagonists partially block high K(+)-, phorbol ester-, Zn(2+)-, and VIP-induced c-fos mRNA expression, but have no effect on bFGF-induced c-fos mRNA expression.	Zinc	62-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
1319617-3	1992	the heparin-neutralizing ability of HRG in the APC inhibition by PCI, however, was decreased in a Ca(2+)-dependent manner and apparently lost at 1 mM Ca2+, while it was enhanced by Zn2+ regardless of the presence or absence of Ca2+.	Zinc	181-185	histidine rich glycoprotein	Homo sapiens	36-39
21345721-7	2011	In addition, the effect of some metal ions Cu(2+), Ca(2+), Mg(2+), and Zn(2+) on the binding constant between SAS and BSA was examined.	Zinc	71-73	tetraspanin 31	Homo sapiens	110-113
1741458-10	1992	In the gram-positive multiple-metal-resistant bacterium Staphylococcus aureus, Cd2+ (and probably Zn2+) efflux is catalyzed by the membrane-bound CadA protein, a P-type ATPase.	Zinc	98-102	CD2 molecule	Canis lupus familiaris	79-82
1741458-13	1992	In the current working model CzcA works as a cation-proton antiporter, CzcB as a cation-binding subunit, and CzcC as a modifier protein required to change the substrate specificity of the system from Zn2+ only to Co2+, Zn2+, and Cd2+.	Zinc	200-204	CD2 molecule	Canis lupus familiaris	229-232
1812786-7	1991	Modulation of PTPase activity by orthovanadate, heparin, Zn2+, and EDTA gave similar results in both assays.	Zinc	57-61	acid phosphatase 1	Bos taurus	14-20
21239534-4	2011	A contributory role of decreases in [Zn](i) in LPS-induced apoptosis (as determined by caspase-3/7 activation, annexin-V binding, and cytochrome c release) in SPAECs was revealed by mimicking the effect of LPS with the zinc chelator, TPEN, and inhibiting LPS- (or TPEN)-induced apoptosis with exogenous zinc.	Zinc	37-39	caspase-3	Ovis aries	87-96
20638923-4	2011	While the OR of CYP 1A1 variants carriers with a higher serum Cu or Cu/Zn ratio level was around 3.38 and 12.59, respectively, the risk of CYP1A1 variants carriers with a higher serum Zn is 0.18, Se 0.04 or Cr(3+) 0.28.	Zinc	71-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-23
20638923-4	2011	While the OR of CYP 1A1 variants carriers with a higher serum Cu or Cu/Zn ratio level was around 3.38 and 12.59, respectively, the risk of CYP1A1 variants carriers with a higher serum Zn is 0.18, Se 0.04 or Cr(3+) 0.28.	Zinc	184-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-23
20638923-4	2011	While the OR of CYP 1A1 variants carriers with a higher serum Cu or Cu/Zn ratio level was around 3.38 and 12.59, respectively, the risk of CYP1A1 variants carriers with a higher serum Zn is 0.18, Se 0.04 or Cr(3+) 0.28.	Zinc	184-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-145
1945883-3	1991	LEU3 proteins with a mutation at Cys47 were very poor activators which could not be rescued by supplying Zn(II) to the growth medium.	Zinc	105-111	leucine-responsive transcriptional regulator LEU3	Saccharomyces cerevisiae S288C	0-4
20638923-6	2011	CONCLUSIONS: Our findings suggested that CYP1A1 or GSTM1 variants may significantly modify the associations between level of serum trace metals (Cu, Zn, Se or Cr) and NSCLC, indicating the intriguing pathogenesis of lung cancer.	Zinc	149-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47
21104143-4	2011	DMT1 mediates the transport of a wide range of metals, including the essential metals Fe2+, Zn2+, Mn2+, Cu2+, Co2+, Ni2+ and toxic metals such as Cd2+ and Pb2+.	Zinc	92-96	solute carrier family 11 member 2	Homo sapiens	0-4
1821809-7	1991	An enzyme-linked immunosorbent assay was developed; a 75% recovery of intact HRG from the immobilized Zn(II) ion affinity column was documented.	Zinc	102-108	histidine rich glycoprotein	Homo sapiens	77-80
1821809-9	1991	These results demonstrate that TED-immobilized Zn(II) ions can be used as a new and efficient method for the isolation of structurally intact human plasma HRG.	Zinc	47-53	histidine rich glycoprotein	Homo sapiens	155-158
1661135-7	1991	Both the basal growth rate in the absence of metal ions and the Zn2+ induced increases in cell proliferation could be inhibited by the monoclonal antibody alpha-IR3, which blocks the binding site of the IGF-I receptor.	Zinc	64-68	insulin like growth factor 1 receptor	Homo sapiens	203-217
20835842-1	2011	Human zeta-crystallin is a Zn(2+)-lacking medium-chain dehydrogenase/reductase (MDR) included in the quinone oxidoreductase (QOR) family because of its activity with quinones.	Zinc	27-29	crystallin zeta	Homo sapiens	101-123
1939451-7	1991	The optimal pH for ferrochelatase was 7.4 and with protoporphyrin and Zn2+ as substrates, the Michaelis constants were 1.49 and 8.33 microM, respectively.	Zinc	70-74	ferrochelatase	Homo sapiens	19-33
20835842-1	2011	Human zeta-crystallin is a Zn(2+)-lacking medium-chain dehydrogenase/reductase (MDR) included in the quinone oxidoreductase (QOR) family because of its activity with quinones.	Zinc	27-29	crystallin zeta	Homo sapiens	125-128
21241850-7	2011	The presence of Zn(2+) (or Cd(2+)) can "turn-on" the weak fluorescence of QDs quenched by S(2-) due to the formation of ZnS (or CdS) passivation shell.	Zinc	16-22	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
21241850-7	2011	The presence of Zn(2+) (or Cd(2+)) can "turn-on" the weak fluorescence of QDs quenched by S(2-) due to the formation of ZnS (or CdS) passivation shell.	Zinc	120-123	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
20378322-10	2011	Osteocalcin mRNA levels were positively correlated to Zn exposure at both time points.	Zinc	54-56	bone gamma-carboxyglutamate protein 2	Mus musculus	0-11
1676831-5	1991	The facilitation of CCK release by NMDA was examined in more detail and shown to be significantly attenuated by Mg2+ (2.5 mM), Zn2+ (50 microM), MK-801 (0.1 and 0.3 microM), aminophosphonovaleric acid (100 microM) and kynurenic acid (100 microM and 300 microM).	Zinc	127-131	cholecystokinin	Rattus norvegicus	20-23
21078376-8	2011	These results suggest that like diabetes, chronic depletion of Zn with TPEN induces testicular oxidative stress and damage, along with the activation of p38 MAPK and p53 signaling and mitochondria-related apoptotic cell death.	Zinc	63-65	transformation related protein 53, pseudogene	Mus musculus	166-169
1899425-1	1991	We have recently reported that in patients with hyperthyroidism, red blood cell (RBC) zinc (Zn), most of which is present as the metal of carbonic anhydrase-I isozyme (CAI), reflects a patient"s integrated thyroid hormone level over the previous few months.	Zinc	92-94	carbonic anhydrase 1	Homo sapiens	138-158
22255137-7	2011	This paper reports on the development of a Point-of-Care device for rap id electrochemical measurement of Zn.	Zinc	106-108	LDL receptor related protein associated protein 1	Homo sapiens	68-71
22125384-4	2011	120 hydroxamic acid derivatives were designed as inhibitors based on hydrophobic pocket and the Zn (II) catalytic site of HDAC8 active site using Structure Based Drug Design (SBDD) approach.	Zinc	96-103	histone deacetylase 8	Homo sapiens	122-127
2211636-5	1990	To examine the role of Zn2+ in terminal transferase catalysis we analyzed for Zn2+ in homogeneous recombinant human terminal transferase preparations and found that Zn2+ is not an intrinsic part of enzyme molecule.	Zinc	23-27	DNA nucleotidylexotransferase	Homo sapiens	31-51
2211636-6	1990	Analysis of Zn2+ binding to terminal transferase under equilibrium conditions shows about 0.3 g of atom of Zn2+/mol of enzyme, suggesting that Zn2+ forms an easily dissociable complex with the enzyme molecule.	Zinc	12-16	DNA nucleotidylexotransferase	Homo sapiens	28-48
2211636-6	1990	Analysis of Zn2+ binding to terminal transferase under equilibrium conditions shows about 0.3 g of atom of Zn2+/mol of enzyme, suggesting that Zn2+ forms an easily dissociable complex with the enzyme molecule.	Zinc	12-15	DNA nucleotidylexotransferase	Homo sapiens	28-48
2211636-6	1990	Analysis of Zn2+ binding to terminal transferase under equilibrium conditions shows about 0.3 g of atom of Zn2+/mol of enzyme, suggesting that Zn2+ forms an easily dissociable complex with the enzyme molecule.	Zinc	107-111	DNA nucleotidylexotransferase	Homo sapiens	28-48
21029107-11	2011	Overexpression of GhBCP1 and GhBCP4 in yeast (Schizosaccharomyces pombe) significantly increased the cell growth rate under Cu(2+) , Zn(2+) and high-salinity stresses.	Zinc	133-135	mavicyanin	Gossypium hirsutum	18-24
2211636-10	1990	These results suggest that Zn2+ is a positive effector for terminal transferase, interacting with oligonucleotide and enzyme near the initiator binding site.	Zinc	27-31	DNA nucleotidylexotransferase	Homo sapiens	59-79
22163318-0	2011	Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit.	Zinc	22-26	carbonic anhydrase 1	Rattus norvegicus	42-45
2116666-2	1990	The Zn(II) binding site from carbonic anhydrase B was used as a model.	Zinc	4-10	carbonic anhydrase 2	Homo sapiens	29-49
22163318-4	2011	Zn(2+) delivery by Zn-CQ transiently attenuated CA1 long-term potentiation (LTP) in hippocampal slices prepared 2 h after i.p.	Zinc	0-2	carbonic anhydrase 1	Rattus norvegicus	48-51
22163318-5	2011	injection of Zn-CQ into rats, when intracellular Zn(2+) levels was transiently increased in the CA1 pyramidal cell layer, followed by object recognition memory deficit.	Zinc	49-55	carbonic anhydrase 1	Rattus norvegicus	96-99
22163318-6	2011	Object recognition memory was transiently impaired 30 min after injection of ZnCl(2) into the CA1, but not after injection into the dentate gyrus that did not significantly increase intracellular Zn(2+) in the granule cell layer of the dentate gyrus.	Zinc	77-79	carbonic anhydrase 1	Rattus norvegicus	94-97
22163318-7	2011	Object recognition memory deficit may be linked to the preferential increase in Zn(2+) and/or the preferential vulnerability to Zn(2+) in CA1 pyramidal neurons.	Zinc	128-130	carbonic anhydrase 1	Rattus norvegicus	138-141
22163318-8	2011	In the case of the cytosolic increase in endogenous Zn(2+) in the CA1 induced by 100 mM KCl, furthermore, object recognition memory was also transiently impaired, while ameliorated by co-injection of CaEDTA to block the increase in cytosolic Zn(2+).	Zinc	52-54	carbonic anhydrase 1	Rattus norvegicus	66-69
2160969-3	1990	This paper presents evidence that a metal ion, probably Zn2+, is an essential cofactor for the Ah receptor.	Zinc	56-60	aryl hydrocarbon receptor	Rattus norvegicus	95-106
22163318-8	2011	In the case of the cytosolic increase in endogenous Zn(2+) in the CA1 induced by 100 mM KCl, furthermore, object recognition memory was also transiently impaired, while ameliorated by co-injection of CaEDTA to block the increase in cytosolic Zn(2+).	Zinc	242-244	carbonic anhydrase 1	Rattus norvegicus	66-69
2160969-11	1990	The Zn2+ requirement of the Ah receptor is similar to that of the estrogen and the glucocorticoid receptors and is consistent with the hypothesis that the Ah receptor is a member of the steroid and thyroid hormone receptor superfamily.	Zinc	4-8	aryl hydrocarbon receptor	Rattus norvegicus	28-39
22163318-9	2011	The present study indicates that the transient increase in cytosolic Zn(2+) in CA1 pyramidal neurons reversibly impairs object recognition memory.	Zinc	69-75	carbonic anhydrase 1	Rattus norvegicus	79-82
2160969-11	1990	The Zn2+ requirement of the Ah receptor is similar to that of the estrogen and the glucocorticoid receptors and is consistent with the hypothesis that the Ah receptor is a member of the steroid and thyroid hormone receptor superfamily.	Zinc	4-8	aryl hydrocarbon receptor	Rattus norvegicus	155-166
21077603-3	2010	The IRPD spectrum of Zn(2+)(H(2)O)(8) is most consistent with the calculated spectrum of the five-coordinate MP2(full) ground-state (GS) species.	Zinc	21-23	tryptase pseudogene 1	Homo sapiens	109-112
20839184-7	2010	Furthermore, complete analysis of recombinant (Escherichia coli) Zn-Cup1, Cd-Cup1, and Cu-Cup1 and those complexes that result from Zn/Cd and Zn/Cu replacements in vitro and acidification/renaturalization processes yielded a comprehensive and comparative overview of the metal-binding abilities of Cup1.	Zinc	65-67	metallothionein CUP1	Saccharomyces cerevisiae S288C	68-72
2190816-8	1990	Zn2(+)-induced expression of the chicken CaM gene in MCM cells increased the rate of proliferation, while Zn2(+)-induced expression of high levels of CaM anti-sense RNA stops proliferation at Zn2+ levels that do not affect the growth of BPV cells.	Zinc	0-6	calmodulin 2	Gallus gallus	41-44
2190816-8	1990	Zn2(+)-induced expression of the chicken CaM gene in MCM cells increased the rate of proliferation, while Zn2(+)-induced expression of high levels of CaM anti-sense RNA stops proliferation at Zn2+ levels that do not affect the growth of BPV cells.	Zinc	106-112	calmodulin 2	Gallus gallus	150-153
2190816-8	1990	Zn2(+)-induced expression of the chicken CaM gene in MCM cells increased the rate of proliferation, while Zn2(+)-induced expression of high levels of CaM anti-sense RNA stops proliferation at Zn2+ levels that do not affect the growth of BPV cells.	Zinc	192-196	calmodulin 2	Gallus gallus	150-153
20660165-5	2010	Both in the absence of extracellular Ca(2+) and in the presence of Cd(2+) or Zn(2+), the SLURP-1-dependent elevation of NF-kappaB was almost completely blocked by inhibiting MEK1 activity.	Zinc	77-79	secreted LY6/PLAUR domain containing 1	Homo sapiens	89-96
2342485-5	1990	This level of induction is substantially reduced when Zn,Cd-MT is added to lymphocyte cultures in the presence of 50 microM 2-mercaptoethanol.	Zinc	54-56	CYLD lysine 63 deubiquitinase	Homo sapiens	57-62
20660165-5	2010	Both in the absence of extracellular Ca(2+) and in the presence of Cd(2+) or Zn(2+), the SLURP-1-dependent elevation of NF-kappaB was almost completely blocked by inhibiting MEK1 activity.	Zinc	77-79	mitogen-activated protein kinase kinase 1	Homo sapiens	174-178
20729526-4	2010	Using partial proteolysis we find that RepE, a folded substrate, contacts a wide DnaJ area that involves part of the G/F-rich region and Zn-binding domain.	Zinc	137-139	DnaJ	Escherichia coli	81-85
20729554-3	2010	Interactions preferentially occurred in the presence of Zn(2+) suggesting that matrilin-3 has acquired a requirement for specific metal ions for activation and/or molecular associations.	Zinc	56-58	matrilin 3	Homo sapiens	79-89
21046948-0	2010	Bleaching of Congo red in the presence of ZnS nanoparticles, with dopant of Co2+ ion, as photocatalyst under UV and sunlight irradiations.	Zinc	42-45	complement C2	Homo sapiens	76-79
20726777-1	2010	Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1.	Zinc	173-175	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	152-157
20522546-2	2010	We show that in the human HaCaT keratinocytes extracellular Zn(2+) induces a metabotropic Ca(2+) response that is abolished by silencing the expression of the G-protein-coupled receptor GPR39, suggesting that this Zn(2+)-sensing receptor, ZnR, is mediating the response.	Zinc	60-62	G protein-coupled receptor 39	Homo sapiens	186-191
20522546-8	2010	Thus our results indicate that extracellular Zn(2+), which is either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair.	Zinc	45-47	G protein-coupled receptor 39	Homo sapiens	121-126
20510875-0	2010	Solution NMR characterization of Sgf73(1-104) indicates that Zn ion is required to stabilize zinc finger motif.	Zinc	61-63	deubiquitination module subunit SGF73	Saccharomyces cerevisiae S288C	33-38
20410362-9	2010	The current remaining showed decreased [Mg](o) affinities reminiscent of NR2C and NR2D subunits but was highly sensitive to [Zn](o), a potent NR2A blocker, showing a approximately 44.2 +/- 1.1% maximal inhibition at saturating concentrations with an IC(50) of 7.8 +/- 1.1 nM.	Zinc	125-127	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	142-146
20428803-7	2010	FBL and CD164 were responsive to the treatment with Zn2+ in PNT2 prostate normal cells and were further overexpressed in the prolonged Zn2+-treated LNCaP cells.	Zinc	52-56	CD164 molecule	Homo sapiens	8-13
20428803-7	2010	FBL and CD164 were responsive to the treatment with Zn2+ in PNT2 prostate normal cells and were further overexpressed in the prolonged Zn2+-treated LNCaP cells.	Zinc	135-139	CD164 molecule	Homo sapiens	8-13
20428803-8	2010	These observations suggest that in general high Zn2+ has suppressive effects on prostate cancer cell growth but continuous exposure to an environment of high Zn2+ can lead to the overexpression of cancer promoting genes such as FBL and CD164.	Zinc	158-162	CD164 molecule	Homo sapiens	236-241
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	Janus kinase 2	Mus musculus	121-125
20129672-7	2010	Whereas, besides DTT, cysteine can also prevent the inhibition of hAS3MT activity by Co(2+), Mn(2+), and Zn(2+).	Zinc	105-107	PDS5 cohesin associated factor B	Homo sapiens	66-70
20449461-1	2010	Using phosphine-free and "green" chalcogen precursors, controlled synthesis of high quality CdS/ZnSe/ZnS core/shell1/shell2 nanocrystals has been successfully carried out using different sized CdS nanocrystals as cores.	Zinc	96-99	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
20407581-12	2010	Since physiological concentrations of the divalent cation Mg(2+) did not affect the I-V dependence, our data suggest that relief of the voltage-dependent Ca(2+) block of NR1/NR3A receptors by Zn(2+) may be important for the regulation of excitatory glycinergic transmission, according to the Mg(2+)-block of conventional NR1/NR2 NMDA receptors.	Zinc	192-194	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	174-178
19371353-1	2010	Our previous studies demonstrate alterations of zinc (Zn) transporter proteins ZnT-1, ZnT-4 and ZnT-6 in vulnerable brain regions of subjects with mild cognitive impairment (MCI), and early and late stage Alzheimer"s disease (AD), suggesting disruptions of Zn homeostasis may play a role in the pathogenesis of AD.	Zinc	54-56	solute carrier family 30 member 6	Homo sapiens	96-101
2107541-1	1990	The DNA-binding domain of the transcription factor GAL4, consisting of the 62 N-terminal residues and denoted GAL4(62*), contains a Cys-Xaa2-Cys-Xaa6-Cys-Xaa6-Cys-Xaa2-Cys-Xaa6+ ++-Cys motif, which has been shown previously to bind two Zn(II) or Cd(II) ions.	Zinc	236-238	galectin 4	Homo sapiens	110-114
2107541-2	1990	Binding of Zn(II) or Cd(II) is essential for the recognition by GAL4 of the specific palindromic DNA sequence to which it binds upstream of genes for galactose-metabolizing enzymes, the UASG sequence.	Zinc	11-17	galectin 4	Homo sapiens	64-68
2107541-8	1990	1H NMR spectra of apo-GAL4(62*) suggest conformational fluctuation of the metal-binding subdomain upon removal of Zn(II) or Cd(II).	Zinc	114-120	galectin 4	Homo sapiens	22-26
19946718-0	2010	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.	Zinc	57-61	insulin-like growth factor 1 receptor	Cricetulus griseus	28-34
19946718-0	2010	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.	Zinc	57-61	epidermal growth factor receptor	Cricetulus griseus	39-43
19946718-0	2010	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.	Zinc	57-61	protein tyrosine kinase 2 beta	Homo sapiens	81-84
19900532-6	2010	MT-I and MT-II were up-regulated in response to both Zn and Cd exposure and, as expected, Cd represented the most potent inducer.	Zinc	53-55	metallothionein 2A	Homo sapiens	9-14
7104037-7	1982	The uptake of Cd2+ by the whole liver and th hepatic metallothionein is not related to the total liver concentration of Zn2+ or copper and is not significantly influenced by the concentration of pre-existing metallothionein or the concentration of thionein-bound Zn2+ or copper.	Zinc	263-267	Cd2 molecule	Rattus norvegicus	14-17
7104037-8	1982	The results are discussed in relation to the possible effects of Cd2+ on the liver metabolism and tissue distribution of Zn2+ and copper in the developing animal.	Zinc	121-125	Cd2 molecule	Rattus norvegicus	65-68
32795642-6	2020	The results showed that low Zn diet significantly aggravated the level of renal apoptosis during diabetes, performed as the upregulation of caspase-3 expression.	Zinc	28-30	caspase 3	Mus musculus	140-149
19768661-9	2010	We conclude that key mechanisms of Zn(2+)-mediated apoptotic induction include disruption of cellular glutathione homeostasis leading to ANT inhibition and decreases in mitochondrial ATP synthesis.	Zinc	35-41	solute carrier family 25 member 6	Homo sapiens	137-140
19747413-3	2010	Two-dimensional gel electrophoresis and MS were applied to identify major protein expression changes in the protein lysates of human Ml7 neuronal cells that had been grown in the presence and absence of Zn and DHA.	Zinc	203-205	solute carrier family 25 member 16	Homo sapiens	133-136
34563529-5	2022	H16 to promote plant growth, but stimulated the production of extracellular polysaccharides and inorganic labile sulfide, and enhanced biofilm formation, thereby significantly improved the removal efficiency of Cu2+, Zn2+, Cd2+, and Pb2+.	Zinc	217-221	H1.6 linker histone, cluster member	Homo sapiens	0-3
19941862-2	2010	Previously, I demonstrated that Zn(2+)-depleted human TrpRS is enzymatically inactive and that binding of Zn(2+) or heme to human TrpRS stimulates its aminoacylation activity.	Zinc	32-38	tryptophanyl tRNA synthetase 2, mitochondrial	Homo sapiens	54-59
19941862-2	2010	Previously, I demonstrated that Zn(2+)-depleted human TrpRS is enzymatically inactive and that binding of Zn(2+) or heme to human TrpRS stimulates its aminoacylation activity.	Zinc	32-38	tryptophanyl tRNA synthetase 2, mitochondrial	Homo sapiens	130-135
19941862-2	2010	Previously, I demonstrated that Zn(2+)-depleted human TrpRS is enzymatically inactive and that binding of Zn(2+) or heme to human TrpRS stimulates its aminoacylation activity.	Zinc	106-112	tryptophanyl tRNA synthetase 2, mitochondrial	Homo sapiens	130-135
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	144-146	endothelin 1	Mus musculus	37-41
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	144-146	angiopoietin 2	Mus musculus	46-51
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	242-244	endothelin 1	Mus musculus	37-41
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	242-244	angiopoietin 2	Mus musculus	46-51
20418627-4	2010	The experiments of photocatalytic H(2) generation showed that the catalysts (CdS)(x)/(ZnS)(1-x) with x ranging from 0.1 to 1 were able to produce hydrogen from water photolysis under visible light.	Zinc	86-89	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
20418627-9	2010	This is attributable to the large band-gap ZnS shell that separates the electron/hole pairs generated by the CdS core and hence reduces their recombinations.	Zinc	43-46	CDP-diacylglycerol synthase 1	Homo sapiens	109-112
19826005-5	2009	Low micromolar concentrations of Zn(2+) dramatically accelerate fibril formation of wild-type Tau(244-372) under reducing conditions, compared with no Zn(2+).	Zinc	33-35	microtubule associated protein tau	Homo sapiens	94-97
19826005-6	2009	Higher concentrations of Zn(2+), however, induce wild-type Tau(244-372) to form granular aggregates in reducing conditions.	Zinc	25-27	microtubule associated protein tau	Homo sapiens	59-62
19826005-7	2009	Moreover, these non-fibrillar aggregates assemble into mature Tau filaments when Zn(2+) has been chelated by EDTA.	Zinc	81-83	microtubule associated protein tau	Homo sapiens	62-65
19826005-9	2009	The results from isothermal titration calorimetry show that one Zn(2+) binds to one Tau molecule via tetrahedral coordination to Cys-291 and Cys-322 as well as two histidines, with moderate, micromolar affinity.	Zinc	64-66	microtubule associated protein tau	Homo sapiens	84-87
19780838-6	2009	Glial cells treated with CdTe quantum dots accumulated newly synthesized lipids in a phosphoinositide 3-kinase-dependent manner, which was consistent with the growth factor-dependent accumulation of lipids in PC12 cells treated with CdTe and CdSe/ZnS quantum dots.	Zinc	247-250	myotrophin	Rattus norvegicus	159-172
19839811-3	2009	RESULTS: Cell treatment with a common fatty acid (oleic acid) within the range of physiological concentrations markedly enhanced the InGaP/ZnS uptake by microglia and afforded their colocalization within lipid droplets/lysosomes but not with mitochondria.	Zinc	139-142	regenerating family member 3 alpha	Homo sapiens	133-138
19624124-0	2009	Homodimerization and heterodimerization of minimal zinc(II)-binding-domain peptides of T-cell proteins CD4, CD8alpha, and Lck.	Zinc	51-59	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
19602149-3	2009	Here, we show that BcrR interacts directly with Zn2+ bacitracin (Kd = 2-5 micropM), but not metal-free bacitracin.	Zinc	48-52	DNA-binding protein	Enterococcus faecalis	19-23
19458277-2	2009	Our previous studies in animal and cell models implicated the Zn transporter Zip3 (Slc39a3) in mammary gland Zn acquisition.	Zinc	62-64	solute carrier family 39 (zinc transporter), member 3	Mus musculus	77-81
34752845-2	2022	TRPM7 mediates a variety of physiological responses by conducting flow of cations such as Ca2+, Mg2+, and Zn2+.	Zinc	106-110	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-5
34752845-3	2022	Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn2+ release to the cytosol, presumably from the intracellular Zn2+-accumulating vesicles where TRPM7 localizes.	Zinc	151-155	transient receptor potential cation channel subfamily M member 7	Homo sapiens	37-42
34752845-3	2022	Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn2+ release to the cytosol, presumably from the intracellular Zn2+-accumulating vesicles where TRPM7 localizes.	Zinc	151-155	transient receptor potential cation channel subfamily M member 7	Homo sapiens	86-91
34752845-3	2022	Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn2+ release to the cytosol, presumably from the intracellular Zn2+-accumulating vesicles where TRPM7 localizes.	Zinc	214-218	transient receptor potential cation channel subfamily M member 7	Homo sapiens	37-42
34752845-3	2022	Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn2+ release to the cytosol, presumably from the intracellular Zn2+-accumulating vesicles where TRPM7 localizes.	Zinc	214-218	transient receptor potential cation channel subfamily M member 7	Homo sapiens	86-91
34752845-3	2022	Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn2+ release to the cytosol, presumably from the intracellular Zn2+-accumulating vesicles where TRPM7 localizes.	Zinc	214-218	transient receptor potential cation channel subfamily M member 7	Homo sapiens	247-252
34752845-4	2022	Zn2+ release following the activation of TRPM7 disrupted the fusion between autophagosomes and lysosomes by disturbing the interaction between Sxt17 and VAMP8 which determines fusion status of autophagosomes and lysosomes.	Zinc	0-4	transient receptor potential cation channel subfamily M member 7	Homo sapiens	41-46
34364212-8	2022	Desorption followed the order Ni>Zn>Pb>Cu, which was attributed to decreased hydrolysis constant (pK1 = 9.4, 9.6, 7.8, 7.5, respectively).	Zinc	33-35	prokineticin 1	Homo sapiens	98-101
34924116-4	2022	Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism.	Zinc	153-155	death associated protein kinase 3	Homo sapiens	187-190
34867993-3	2021	Herein, we identify that the caspase-11 inflammasome in mouse and human macrophages (Mphi) is negatively controlled by the zinc (Zn2+) regulating protein, metallothionein 3 (MT3).	Zinc	129-133	metallothionein 3	Homo sapiens	155-172
34867993-3	2021	Herein, we identify that the caspase-11 inflammasome in mouse and human macrophages (Mphi) is negatively controlled by the zinc (Zn2+) regulating protein, metallothionein 3 (MT3).	Zinc	129-133	metallothionein 3	Homo sapiens	174-177
34867993-5	2021	Mechanistically, MT3 increased intramacrophage Zn2+ to downmodulate the TRIF-IRF3-STAT1 axis that is prerequisite for caspase-11 effector function.	Zinc	47-51	metallothionein 3	Homo sapiens	17-20
34867993-5	2021	Mechanistically, MT3 increased intramacrophage Zn2+ to downmodulate the TRIF-IRF3-STAT1 axis that is prerequisite for caspase-11 effector function.	Zinc	47-51	signal transducer and activator of transcription 1	Homo sapiens	82-87
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	cAMP responsive element binding protein 1	Homo sapiens	167-204
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	cAMP responsive element binding protein 1	Homo sapiens	206-210
34831318-5	2021	By activating TRKB-mediated extracellular signal-regulated kinase (ERK) and AKT serine/threonine kinase 1 (AKT) signaling, these two ZN compounds also upregulated the cAMP-response-element binding protein (CREB) and its downstream BDNF and anti-apoptotic B-cell lymphoma 2 (BCL2).	Zinc	133-135	brain derived neurotrophic factor	Homo sapiens	231-235
34644082-3	2021	Herein, we examine the structure, spectroscopy, and magnetic exchange coupling in two biradicals (1,3-SQ2Az and 1,3-SQ-Az-NN; SQ = the zinc(II) complex of spin-1/2 semiquinone radical anion, NN = spin-1/2 nitronylnitroxide; Az = azulene) that possess nonalternant azulene pi-system bridges.	Zinc	135-143	spindlin 1	Homo sapiens	155-163
34709124-6	2021	Analysis of the molecular docking suggests that these drugs were bound to TACE"s catalytic domain and interact with the key residues such as His405, Glu406, and His415, which are involved in active site Zn2+ ion chelation.	Zinc	203-207	ADAM metallopeptidase domain 17	Homo sapiens	74-78
34560438-6	2021	The groups receiving Zn or Cu chelate showed statistically confirmed higher activity of superoxide dismutase, catalase, and a higher level of glutathione in comparison to the group receiving Fe chelate.	Zinc	21-23	catalase	Gallus gallus	110-118
34639491-11	2021	High correlation coefficients (r >= 0.8) were found for the elements Mg, Ca, Fe, Al, Cd, Pb, and Zn in the PM1 fraction, Cd, Pb, and Zn in PM2.5, and Ba, Sb, Fe, Cu, Cr, Mg, Al, and Ca in PM2.5-10.	Zinc	97-99	transmembrane protein 11	Homo sapiens	107-110
34631763-14	2021	The n-6/n-3 ratio in plasma phospholipids was elevated (12.25 +- 3.45) and patients with inadequate Zn intake had lower n-3 PUFA intake and status compared to those with adequate intake.	Zinc	100-102	pumilio RNA binding family member 3	Homo sapiens	124-128
34174323-9	2021	SIGNIFICANCE: BBR plus Zn could be used as a novel therapy for the treatment of MTX-induced intestinal damage through modulation of GSK-3beta/NRF2, Akt/mTOR, JAK1/STAT-3, and SIRT1/FOXO-3 signaling pathways.	Zinc	23-25	mechanistic target of rapamycin kinase	Rattus norvegicus	152-156
34296610-1	2021	This work describes the synthesis and characterization of a Zn-based metal-organic framework, (Zn2(TTPA)(SDB)2 (DMF)(H2O))n (1, TTPA = tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine, SDB = 4,4"-sulfonyldibenzoate).	Zinc	60-62	alpha tocopherol transfer protein	Homo sapiens	99-103
34296610-1	2021	This work describes the synthesis and characterization of a Zn-based metal-organic framework, (Zn2(TTPA)(SDB)2 (DMF)(H2O))n (1, TTPA = tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine, SDB = 4,4"-sulfonyldibenzoate).	Zinc	60-62	alpha tocopherol transfer protein	Homo sapiens	128-132
34296610-2	2021	A newly designed strategy with a redox-active linker, TTPA, and mediated by a V-shaped carboxylic linker with Zn2+ metal ions resulted in an electroactive framework.	Zinc	110-114	alpha tocopherol transfer protein	Homo sapiens	54-58
34296610-3	2021	The V-shaped carboxylic linker with Zn2+ metal ions forms linear struts interlinked by two of the side-arms of the TTPA ligands to form a square grid network.	Zinc	36-40	alpha tocopherol transfer protein	Homo sapiens	115-119
35611945-4	2022	The pGr-MoS2/GCE exhibited selectivity towards DHBI, in the presence of other toxic contaminants and metal ions such as phenol, dinitrophenol, trinitrophenol, urea and glucose, Hg(II), Ca(II), Ni(II), Zn(II), Cu(II), Na(I) and K(I).	Zinc	201-203	carbonic anhydrase 2	Homo sapiens	185-191
35625653-1	2022	The human (h) transporter hZIP4 is the primary Zn2+ importer in the intestine.	Zinc	47-51	solute carrier family 39 member 4	Homo sapiens	26-31
19458277-2	2009	Our previous studies in animal and cell models implicated the Zn transporter Zip3 (Slc39a3) in mammary gland Zn acquisition.	Zinc	62-64	solute carrier family 39 (zinc transporter), member 3	Mus musculus	83-90
19458277-6	2009	Consistent with this localization, Zn transfer studies using (65)Zn revealed that Zn retention in the secreted milk pool and milk Zn concentration was higher in Zip3-null compared with wild-type mice.	Zinc	35-37	solute carrier family 39 (zinc transporter), member 3	Mus musculus	161-165
35625653-3	2022	Dysfunction of hZIP4 can result in the Zn2+ deficiency disease acrodermatitis enteropathica (AE).	Zinc	39-43	solute carrier family 39 member 4	Homo sapiens	15-20
19458277-6	2009	Consistent with this localization, Zn transfer studies using (65)Zn revealed that Zn retention in the secreted milk pool and milk Zn concentration was higher in Zip3-null compared with wild-type mice.	Zinc	65-67	solute carrier family 39 (zinc transporter), member 3	Mus musculus	161-165
19458277-6	2009	Consistent with this localization, Zn transfer studies using (65)Zn revealed that Zn retention in the secreted milk pool and milk Zn concentration was higher in Zip3-null compared with wild-type mice.	Zinc	65-67	solute carrier family 39 (zinc transporter), member 3	Mus musculus	161-165
35446024-3	2022	This study aimed to engineer TIMP2, one of the four homologous TIMPs, as a potential therapeutic by virtue of its ability to bind to the active-site Zn2+ of MMP-14.	Zinc	149-153	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	157-163
19458277-6	2009	Consistent with this localization, Zn transfer studies using (65)Zn revealed that Zn retention in the secreted milk pool and milk Zn concentration was higher in Zip3-null compared with wild-type mice.	Zinc	65-67	solute carrier family 39 (zinc transporter), member 3	Mus musculus	161-165
19097988-8	2009	Ni-induced increases in MT2A mRNA and MRE-luciferase activity were sensitive to the Zn chelator, TPEN, supporting an important role for Zn in mediating the effect of Ni.	Zinc	84-86	metallothionein 2A	Homo sapiens	24-28
19097988-8	2009	Ni-induced increases in MT2A mRNA and MRE-luciferase activity were sensitive to the Zn chelator, TPEN, supporting an important role for Zn in mediating the effect of Ni.	Zinc	136-138	metallothionein 2A	Homo sapiens	24-28
19447499-8	2009	In order to determine the metal binding properties of the N-terminal fragment of endostatin, we performed equilibrium, UV-visible (UV-vis), CD, EPR and NMR studies on the zinc(II) and copper(II) complexes of L. In the presence of zinc(II) the formation of a stable [NH(2),3N(im),COO(-)] coordinated complex was detected in the neutral pH-range.	Zinc	171-179	collagen type XVIII alpha 1 chain	Homo sapiens	81-91
35451192-6	2022	With the optimal 3 m Zn(OTF)2 in (H2 O-HAc)/TMS acidic electrolyte (pH 1.6), the Zn electrode exhibits a coulombic efficiency of >99.8% and smooth Zn deposition.	Zinc	81-83	POU class 2 homeobox 2	Homo sapiens	21-29
35566234-0	2022	Insight into Spodium-pi Bonding Characteristics of the MX2 pi (M = Zn, Cd and Hg; X = Cl, Br and I) Complexes-A Theoretical Study.	Zinc	67-69	MX dynamin like GTPase 2	Homo sapiens	55-58
19447499-8	2009	In order to determine the metal binding properties of the N-terminal fragment of endostatin, we performed equilibrium, UV-visible (UV-vis), CD, EPR and NMR studies on the zinc(II) and copper(II) complexes of L. In the presence of zinc(II) the formation of a stable [NH(2),3N(im),COO(-)] coordinated complex was detected in the neutral pH-range.	Zinc	230-238	collagen type XVIII alpha 1 chain	Homo sapiens	81-91
35566234-1	2022	The spodium-pi bonding between MX2 (M = Zn, Cd, and Hg; X = Cl, Br, and I) acting as a Lewis acid, and C2H2/C2H4 acting as a Lewis base was studied by ab initio calculations.	Zinc	40-42	MX dynamin like GTPase 2	Homo sapiens	31-34
19447499-9	2009	This coordination mode is probably identical to that present in the zinc(II) complex of the above mentioned N-terminal 25-mer peptide fragment of human endostatin.	Zinc	68-76	collagen type XVIII alpha 1 chain	Homo sapiens	152-162
19430470-1	2009	We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury.	Zinc	130-132	solute carrier family 12 member 5	Rattus norvegicus	14-41
35233951-0	2022	V2 O3 /MnS Arrays as Bifunctional Air Electrode for Long-Lasting and Flexible Rechargeable Zn-Air Batteries.	Zinc	91-93	glycophorin E (MNS blood group)	Homo sapiens	7-10
19430470-1	2009	We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury.	Zinc	130-132	solute carrier family 12 member 5	Rattus norvegicus	43-47
19430470-2	2009	Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons.	Zinc	0-6	solute carrier family 12 member 5	Rattus norvegicus	16-20
19430470-4	2009	The link between Zn(2+) and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission.	Zinc	17-19	solute carrier family 12 member 5	Rattus norvegicus	28-32
19433490-1	2009	A mutant line of Arabidopsis thaliana that lacks a vacuolar membrane Zn(2+)/H(+) antiporter MTP1 is sensitive to zinc.	Zinc	69-71	zinc transporter	Arabidopsis thaliana	92-96
19433490-12	2009	These results indicate an essential role of MTP1 in detoxification of excessive Zn and provide novel information on the latent adaptation mechanism to Zn stress, which is hidden by MTP1.	Zinc	80-82	zinc transporter	Arabidopsis thaliana	44-48
19433490-12	2009	These results indicate an essential role of MTP1 in detoxification of excessive Zn and provide novel information on the latent adaptation mechanism to Zn stress, which is hidden by MTP1.	Zinc	151-153	zinc transporter	Arabidopsis thaliana	181-185
18947441-7	2009	Also, we established that mRNA levels of the Zn-responsive metal response element binding transcription factor (MTF)-1, and its homologue MTF-2, are regulated by Zn in Caco-2 but not JAR cells, which may in part underlie differential gene responses to Zn in intestinal and placental cells.	Zinc	45-47	metal response element binding transcription factor 2	Homo sapiens	138-143
18947441-7	2009	Also, we established that mRNA levels of the Zn-responsive metal response element binding transcription factor (MTF)-1, and its homologue MTF-2, are regulated by Zn in Caco-2 but not JAR cells, which may in part underlie differential gene responses to Zn in intestinal and placental cells.	Zinc	162-164	metal response element binding transcription factor 2	Homo sapiens	138-143
19135505-0	2009	Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons.	Zinc	14-18	carbonic anhydrase 1	Mus musculus	112-115
19095042-0	2009	Silencing of ZnT1 reduces Zn2+ efflux in cultured cortical neurons.	Zinc	26-30	solute carrier family 30 member 1	Rattus norvegicus	13-17
19095042-3	2009	The plasma membrane bound transporter ZnT1 is suggested to lower intracellular Zn2+ concentration.	Zinc	79-83	solute carrier family 30 member 1	Rattus norvegicus	38-42
19095042-8	2009	Reducing ZnT1 expression caused Zn2+ efflux to decrease compared with the Zn2+ efflux measured in nonsense transfected neurons, suggesting that ZnT1 plays a direct role in Zn2+ efflux.	Zinc	32-36	solute carrier family 30 member 1	Rattus norvegicus	9-13
19095042-8	2009	Reducing ZnT1 expression caused Zn2+ efflux to decrease compared with the Zn2+ efflux measured in nonsense transfected neurons, suggesting that ZnT1 plays a direct role in Zn2+ efflux.	Zinc	32-36	solute carrier family 30 member 1	Rattus norvegicus	144-148
19095042-8	2009	Reducing ZnT1 expression caused Zn2+ efflux to decrease compared with the Zn2+ efflux measured in nonsense transfected neurons, suggesting that ZnT1 plays a direct role in Zn2+ efflux.	Zinc	32-35	solute carrier family 30 member 1	Rattus norvegicus	9-13
19095042-8	2009	Reducing ZnT1 expression caused Zn2+ efflux to decrease compared with the Zn2+ efflux measured in nonsense transfected neurons, suggesting that ZnT1 plays a direct role in Zn2+ efflux.	Zinc	32-35	solute carrier family 30 member 1	Rattus norvegicus	144-148
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	15-19	solute carrier family 30 member 1	Rattus norvegicus	0-4
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	15-19	solute carrier family 30 member 1	Rattus norvegicus	106-110
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	175-179	solute carrier family 30 member 1	Rattus norvegicus	0-4
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	175-179	solute carrier family 30 member 1	Rattus norvegicus	106-110
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	175-179	solute carrier family 30 member 1	Rattus norvegicus	0-4
19095042-9	2009	ZnT1 dependent Zn2+ efflux rate was higher in the first 10 min than at later time periods suggesting that ZnT1-mediated efflux was heavily dependent on the intracellular free Zn2+ concentration and/or required an outwardly directed Zn2+ gradient.	Zinc	175-179	solute carrier family 30 member 1	Rattus norvegicus	106-110
19076718-1	2009	The Zn/Cd-transporting ATPases, HMA2 and HMA4, essential for root-to-shoot Zn translocation, are also able to transport Cd.	Zinc	4-6	heavy metal atpase 2	Arabidopsis thaliana	32-36
19076719-1	2009	The Zn/Cd-transporting ATPase, HMA2, has N- and C-terminal domains that can bind Zn ions with high affinity.	Zinc	4-6	heavy metal atpase 2	Arabidopsis thaliana	31-35
18541455-9	2008	Doping of CdS with Zn2+ and Cu2+ is found to enhance the PL intensity.	Zinc	19-23	CDP-diacylglycerol synthase 1	Homo sapiens	10-13
35203006-7	2022	We found that AtTIP2;2 is involved in retaining excess Zn in the root, limiting its translocation to the shoot, and facilitating its accumulation in the leaf trichome.	Zinc	55-57	tonoplast intrinsic protein 2	Arabidopsis thaliana	14-20
35203006-8	2022	Furthermore, when expressed in yeast, the tonoplast-localized AtTIP2;2 renders glutathione (GSH)-dependent Zn resistance to yeast cells, suggesting that AtTIP2;2 facilitates the across-tonoplast transport of GSH-Zn complexes.	Zinc	107-109	tonoplast intrinsic protein 2;2	Arabidopsis thaliana	62-70
35203006-8	2022	Furthermore, when expressed in yeast, the tonoplast-localized AtTIP2;2 renders glutathione (GSH)-dependent Zn resistance to yeast cells, suggesting that AtTIP2;2 facilitates the across-tonoplast transport of GSH-Zn complexes.	Zinc	107-109	tonoplast intrinsic protein 2;2	Arabidopsis thaliana	153-161
35133393-6	2022	Specifically, our results indicate that the first Zn atom showed a tendency to occupy the Ca(II) site first, and the subsequent Zn atoms entering the Ca(II) sites in a symmetrical manner.	Zinc	50-52	carbonic anhydrase 2	Homo sapiens	90-96
35133393-6	2022	Specifically, our results indicate that the first Zn atom showed a tendency to occupy the Ca(II) site first, and the subsequent Zn atoms entering the Ca(II) sites in a symmetrical manner.	Zinc	50-52	carbonic anhydrase 2	Homo sapiens	150-156
35133393-6	2022	Specifically, our results indicate that the first Zn atom showed a tendency to occupy the Ca(II) site first, and the subsequent Zn atoms entering the Ca(II) sites in a symmetrical manner.	Zinc	128-130	carbonic anhydrase 2	Homo sapiens	150-156
35118363-3	2022	Using KCC2 truncated mutants, we show that KCC2 C-terminal domain is essential for membrane targeting and SNAP23-dependent upregulation of KCC2 activity triggered by activation of the Zn2+-sensitive receptor mZnR/GPR39 in HEK293 cells.	Zinc	184-188	solute carrier family 12 member 5	Homo sapiens	43-47
35118363-3	2022	Using KCC2 truncated mutants, we show that KCC2 C-terminal domain is essential for membrane targeting and SNAP23-dependent upregulation of KCC2 activity triggered by activation of the Zn2+-sensitive receptor mZnR/GPR39 in HEK293 cells.	Zinc	184-188	synaptosome associated protein 23	Homo sapiens	106-112
35118363-3	2022	Using KCC2 truncated mutants, we show that KCC2 C-terminal domain is essential for membrane targeting and SNAP23-dependent upregulation of KCC2 activity triggered by activation of the Zn2+-sensitive receptor mZnR/GPR39 in HEK293 cells.	Zinc	184-188	solute carrier family 12 member 5	Homo sapiens	139-143
35046970-0	2021	Genetic Correlation Between Fe and Zn Biofortification and Yield Components in a Common Bean (Phaseolus vulgaris L.).	Zinc	35-37	brain expressed associated with NEDD4 1	Homo sapiens	88-92
35046970-3	2021	Bean is a target for biofortification to develop new cultivars with high Fe/Zn levels that help to ameliorate malnutrition mainly in developing countries.	Zinc	76-78	brain expressed associated with NEDD4 1	Homo sapiens	0-4
34994293-6	2022	NF-kappaB and DNMT activities were a significant increase in the 2100 MHz EMF group compared to the control group, although were statistically decreased in the 50, 100 and 200 microM Zn + 2100 MHz EMF groups compared to the 2100 MHz EMF group.	Zinc	183-185	DNA methyltransferase 1	Homo sapiens	14-18
2804139-7	1989	Of the metalloporphyrins examined (Fe, Co, Zn and Sn) all inhibited ferrochelatase at micromolar concentrations, although tin protoporphyrin was the least effective.	Zinc	43-45	ferrochelatase	Mus musculus	68-82
2620798-6	1989	To elucidate the mechanism of this inhibition, binding of Zn(II) (0.5-50 microM 65ZnCl2) to CAM in the presence of Ca(II) (200 microM) was also studied.	Zinc	58-64	carbonic anhydrase 2	Homo sapiens	115-121
2620798-7	1989	The maximum molecular ratio of Zn(II) to CAM in the Zn(II)/Ca(II)/CAM complex approached 0.5.	Zinc	31-37	carbonic anhydrase 2	Homo sapiens	59-65
2620798-7	1989	The maximum molecular ratio of Zn(II) to CAM in the Zn(II)/Ca(II)/CAM complex approached 0.5.	Zinc	52-58	carbonic anhydrase 2	Homo sapiens	59-65
18690663-3	2008	Here, four Zn(II) complexes of invertebrate MTs (mollusc, insect, nematode, and echinoderm) and the Zn(II)-MT complex of the mammalian MT1 isoform, heterologously synthesized in E. coli, were studied by analytic and spectroscopic techniques.	Zinc	11-17	metallothionein 1I, pseudogene	Homo sapiens	135-138
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	33-39	carbonic anhydrase 2	Homo sapiens	65-71
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	33-39	carbonic anhydrase 2	Homo sapiens	199-205
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	33-39	carbonic anhydrase 2	Homo sapiens	199-205
2620798-8	1989	Thus, the observed inhibition by Zn(II) of the Ni(II) binding to Ca(II)/CAM does not involve competition for the same binding sites but is rather caused by a conformational arrangement of CAM in its Ca(II)/Zn(II) complex that is different than the Ca(II) complex.	Zinc	206-212	carbonic anhydrase 2	Homo sapiens	65-71
2508514-4	1989	The increase in SAA concentration coincided with decreasing serum Zn and Fe concentrations; however, with decreasing serum Zn and Fe concentrations; however, Zn and Fe concentrations appeared to be restored when SAA concentration was still maximal.	Zinc	66-68	serum amyloid A protein	Bos taurus	16-19
2530465-3	1989	However, S-100b in the presence of Zn2+ almost doubled the ATPase activity in brain myelin.	Zinc	35-39	S100 calcium binding protein B	Bos taurus	9-15
2530465-5	1989	The observations may indicate a "second messenger" role for S-100b in the presence of Zn2+ in the Schwann cell.	Zinc	86-90	S100 calcium binding protein B	Bos taurus	60-66
2901990-3	1988	A domain constituting amino acid 250-555 positioned within the catalytic domain shows very clear homology to E. coli aminopeptidase N and contains Zn2+ ligands.	Zinc	147-151	aminopeptidase N	Escherichia coli	117-133
3401446-2	1988	Zn2+ and Ca2+ affect the conformation of bovine brain S100b (beta beta) protein and the exposure of its Cys-84 beta.	Zinc	0-4	S100 calcium binding protein B	Bos taurus	54-59
3401446-3	1988	Zn2+ binding to high-affinity sites of native S100b protected the sulfhydryl groups against the thiol-specific reagent 5,5"-dithiobis(2-nitrobenzoate) and antagonized the Ca2+-stimulated reactivity of Cys-84 beta toward the reagent.	Zinc	0-4	S100 calcium binding protein B	Bos taurus	46-51
3401446-4	1988	Spectroscopic studies on the fluorescence properties of labeled S100b with the fluorescent probes bimane and acrylodan at Cys-84 beta confirmed the antagonistic effect of Ca2+ and Zn2+ with respect to the conformational properties of the protein.	Zinc	180-184	S100 calcium binding protein B	Bos taurus	64-69
3401446-5	1988	Measurements of fluorescence dynamics on bimane-labeled S100b indicated that the slow monomer-dimer equilibrium that characterizes the apoprotein at micromolar concentrations was shifted to the monomer form in the presence of Zn2+, a fact that could explain the previously reported Zn2+-dependent increase of S100b protein affinity for calcium.	Zinc	226-230	S100 calcium binding protein B	Bos taurus	56-61
3401446-5	1988	Measurements of fluorescence dynamics on bimane-labeled S100b indicated that the slow monomer-dimer equilibrium that characterizes the apoprotein at micromolar concentrations was shifted to the monomer form in the presence of Zn2+, a fact that could explain the previously reported Zn2+-dependent increase of S100b protein affinity for calcium.	Zinc	226-230	S100 calcium binding protein B	Bos taurus	309-314
3401446-5	1988	Measurements of fluorescence dynamics on bimane-labeled S100b indicated that the slow monomer-dimer equilibrium that characterizes the apoprotein at micromolar concentrations was shifted to the monomer form in the presence of Zn2+, a fact that could explain the previously reported Zn2+-dependent increase of S100b protein affinity for calcium.	Zinc	282-286	S100 calcium binding protein B	Bos taurus	56-61
3401446-6	1988	The difference in the effects of Ca2+ and Zn2+ on the reactivity of Cys-84 beta in S100b was confirmed when we observed that Ca2+ and Zn2+ have opposite actions on the formation of disulfide bridges between Cys-84 beta of the S100b beta-subunit and sulfhydryl groups on the microtubule-associated tau(2) protein.	Zinc	42-46	S100 calcium binding protein B	Bos taurus	83-88
3401446-6	1988	The difference in the effects of Ca2+ and Zn2+ on the reactivity of Cys-84 beta in S100b was confirmed when we observed that Ca2+ and Zn2+ have opposite actions on the formation of disulfide bridges between Cys-84 beta of the S100b beta-subunit and sulfhydryl groups on the microtubule-associated tau(2) protein.	Zinc	42-46	S100 calcium binding protein B	Bos taurus	226-231
3401446-6	1988	The difference in the effects of Ca2+ and Zn2+ on the reactivity of Cys-84 beta in S100b was confirmed when we observed that Ca2+ and Zn2+ have opposite actions on the formation of disulfide bridges between Cys-84 beta of the S100b beta-subunit and sulfhydryl groups on the microtubule-associated tau(2) protein.	Zinc	134-138	S100 calcium binding protein B	Bos taurus	83-88
3401446-6	1988	The difference in the effects of Ca2+ and Zn2+ on the reactivity of Cys-84 beta in S100b was confirmed when we observed that Ca2+ and Zn2+ have opposite actions on the formation of disulfide bridges between Cys-84 beta of the S100b beta-subunit and sulfhydryl groups on the microtubule-associated tau(2) protein.	Zinc	134-138	S100 calcium binding protein B	Bos taurus	226-231
3401446-8	1988	We suggest that Zn2+ may have a modulatory function on Cys-84 beta reactivity in the S100b beta-subunit in vivo.	Zinc	16-20	S100 calcium binding protein B	Bos taurus	85-90
9944652-0	1988	Spin-polarized electronic structure of Cr impurities in ZnS.	Zinc	56-59	spindlin 1	Homo sapiens	0-4
3034814-4	1987	Hepatic activity of alcohol dehydrogenase (EC 1.1.1.1) and cytochrome oxidase (EC 1.9.3.1) paralleled Zn and Cu concentrations respectively.	Zinc	102-104	aldo-keto reductase family 1 member A1	Gallus gallus	20-41
4060972-8	1985	Eliminating the trace amount (0.8 nM) of Zn2+ in MEM by chelation with EDTA decreased rIGF-II secretion to 62% of control levels (P less than 0.01), while increasing the concentration of this cation to 3 mM did not alter the basal release of this SM.	Zinc	41-45	insulin-like growth factor 2	Rattus norvegicus	86-93
4003387-2	1985	It was observed with either human or bovine thrombin that 0.01-0.1 mM Zn+2 induced significant reductions of clotting times in a concentration-dependent manner.	Zinc	70-74	coagulation factor II, thrombin	Bos taurus	44-52
3986189-7	1985	The peptide represents a binding domain of HRG since it retains much of the ability of intact HRG to bind heme and metals including Zn2+, Ni2+, and Cu2+.	Zinc	132-136	histidine rich glycoprotein	Homo sapiens	43-46
3986189-7	1985	The peptide represents a binding domain of HRG since it retains much of the ability of intact HRG to bind heme and metals including Zn2+, Ni2+, and Cu2+.	Zinc	132-136	histidine rich glycoprotein	Homo sapiens	94-97
3966559-1	1985	The purpose of this study was to examine the effect of three common divalent cations (Ca2+, Mg2+, and Zn2+) on the release of cholecystokinin (CCK-33), pancreatic polypeptide (PP), and gastrin.	Zinc	102-106	cholecystokinin	Canis lupus familiaris	126-141
3966559-1	1985	The purpose of this study was to examine the effect of three common divalent cations (Ca2+, Mg2+, and Zn2+) on the release of cholecystokinin (CCK-33), pancreatic polypeptide (PP), and gastrin.	Zinc	102-106	cholecystokinin	Canis lupus familiaris	143-146
3964836-4	1985	The properties of the Ca2+ and Zn2+ binding sites on rat S100b protein were investigated by flow dialysis and by fluorometric titration, and the conformation of rat S100b in its metal-free form as well as in the presence of Ca2+ or Zn2+ was studied.	Zinc	31-35	S100 calcium binding protein B	Rattus norvegicus	57-62
18948096-4	2008	The present study had a focus on the human retinal pigment epithelial (RPE) cell line ARPE-19 in an attempt to demonstrate a reduction in intracellular Cd(2+) effect associated with heme oxygenase-1 (HO-1) expression by co-exposure with zinc (Zn(2+)) or manganese (Mn(2+)), which is known to be a more potent inhibitor of Cd(2+) uptake than Zn(2+).	Zinc	243-245	heme oxygenase 1	Homo sapiens	200-204
6691985-7	1984	Marked changes are observed in the CD spectrum which can be associated with a two-phase reaction: initially Zn2+ is displaced by the Cd2+, then at higher concentrations of Cd2+ the tetrahedral geometry of the Cd2+-binding sites is lost as more Cd2+ is bound using the same thiolate groups.	Zinc	108-112	Cd2 molecule	Rattus norvegicus	133-136
18948096-4	2008	The present study had a focus on the human retinal pigment epithelial (RPE) cell line ARPE-19 in an attempt to demonstrate a reduction in intracellular Cd(2+) effect associated with heme oxygenase-1 (HO-1) expression by co-exposure with zinc (Zn(2+)) or manganese (Mn(2+)), which is known to be a more potent inhibitor of Cd(2+) uptake than Zn(2+).	Zinc	341-343	heme oxygenase 1	Homo sapiens	200-204
6691985-7	1984	Marked changes are observed in the CD spectrum which can be associated with a two-phase reaction: initially Zn2+ is displaced by the Cd2+, then at higher concentrations of Cd2+ the tetrahedral geometry of the Cd2+-binding sites is lost as more Cd2+ is bound using the same thiolate groups.	Zinc	108-112	Cd2 molecule	Rattus norvegicus	172-175
6691985-7	1984	Marked changes are observed in the CD spectrum which can be associated with a two-phase reaction: initially Zn2+ is displaced by the Cd2+, then at higher concentrations of Cd2+ the tetrahedral geometry of the Cd2+-binding sites is lost as more Cd2+ is bound using the same thiolate groups.	Zinc	108-112	Cd2 molecule	Rattus norvegicus	172-175
18922025-7	2008	Cytidylyltransferases require a divalent cation for catalysis, and the cation preference of CCT1 was found to be as follows: Mg (2+) &gt; Mn (2+) = Co (2+) &gt; Ca (2+) = Ni (2+) &gt; Zn (2+).	Zinc	184-186	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	92-96
6691985-7	1984	Marked changes are observed in the CD spectrum which can be associated with a two-phase reaction: initially Zn2+ is displaced by the Cd2+, then at higher concentrations of Cd2+ the tetrahedral geometry of the Cd2+-binding sites is lost as more Cd2+ is bound using the same thiolate groups.	Zinc	108-112	Cd2 molecule	Rattus norvegicus	172-175
6288708-7	1982	The kinetic parameters Km and Vmax for the pyridoxal kinase reaction were determined for ATP and the diastereomers of ATP beta S in the presence of Mg(II), Co(II), Zn(II), and Cd(II).	Zinc	164-170	pyridoxal kinase	Homo sapiens	43-59
21832764-0	2008	Traps and performance of MEH-PPV/CdSe(ZnS) nanocomposite-based organic light-emitting diodes.	Zinc	38-41	epoxide hydrolase 1	Homo sapiens	25-28
7032600-14	1981	Zn2+ decreased the rate of inactivation of the mercurial-labelled kinase by proteinase A.	Zinc	0-4	proteinase A	Saccharomyces cerevisiae S288C	76-88
18550540-4	2008	Here, we present the crystal structures of mouse CN2 complexed with bestatin together with Zn(2+) at a resolution of 1.7 A and that with Mn(2+) at 2.3 A CN2 is a homodimer in a noncrystallographic asymmetric unit, and the Mn(2+) and Zn(2+) complexes closely resemble each other in the overall structure.	Zinc	91-93	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	49-52
6272741-3	1981	The cell-external-surface protein kinase requires Mg2+ for activity, and other bivalent cations such as Mn2+ and Co2+ can substitute partially for Mg2+, whereas Ca2+ and Zn2+ are potent inhibitors of the enzyme.	Zinc	170-174	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	26-40
18550540-4	2008	Here, we present the crystal structures of mouse CN2 complexed with bestatin together with Zn(2+) at a resolution of 1.7 A and that with Mn(2+) at 2.3 A CN2 is a homodimer in a noncrystallographic asymmetric unit, and the Mn(2+) and Zn(2+) complexes closely resemble each other in the overall structure.	Zinc	233-235	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	49-52
18307831-8	2008	The Zn-deficient group had a 49-62% lower production of Th1 cytokines (IL-2), but no difference in the production of Th2 cytokines (IL-6, IL-10) by stimulated splenocytes compared with the pair-fed, marginally Zn-deficient and control groups (P&lt;0.01).	Zinc	4-6	interleukin 2	Rattus norvegicus	71-75
7470991-3	1980	The stimulation of sugar transport by insulin, hyperosmolarity, K+-free medium, or 10(-5) M ouabain was strongly antagonized by Ni2+, Zn2+, and La3+ but was unaffected by Co2+ and Mn2+.	Zinc	134-138	insulin	Cavia porcellus	38-45
18782483-6	2008	The LVA-LZ group tended to show decreased amounts of the BDNF and NGF, while animals supplemented with high vitamin A along with Zn deficiency had high BDNF and NGF concentrations.	Zinc	129-131	brain derived neurotrophic factor	Mus musculus	152-156
7448618-3	1980	The LCAT preparation was pure according to alkaline polyacrylamide and SDS-polyacrylamide gel electrophoresis and did not react against antisera to apo AI, AII, and D. The LCAT preparation obtained by preparative electrophoresis was stimulated by Cu2+, Ni2+, Co2+, and Zn2+ at both stages of the reaction, phospholipase reaction and cholesterol esterification.	Zinc	269-273	lecithin-cholesterol acyltransferase	Homo sapiens	172-176
84485-4	1979	A greater total penetration of 65Zn was found from a carrier-free 65Zn-zinc chloride solution at pH 1 than from the same solution made less acidic (pH 4) and from a zinc oxide suspension at pH 8 (125 microgram Zn/ml).	Zinc	33-35	prolyl 4-hydroxylase, transmembrane	Rattus norvegicus	148-152
18646877-3	2008	The addition of 0.1 ML Zn to the Cu results in the complete conversion of CO 2 (delta-) to carbonate.	Zinc	23-25	complement C2	Homo sapiens	74-78
18711142-0	2008	Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.	Zinc	69-73	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	32-36
33969988-2	2021	Herein, the layered K0.36H0.26MnO2 0.28H2O (K36) with a proton and Zn2+ cointercalation mechanism leads to a progressive phase evolution from layer-type K36 to hybrid layer-type KxHyZnzMnO2 nH2O and spinel-type ZnMn2O4 nanocrystal after a long-term cycle.	Zinc	67-71	keratin 36	Homo sapiens	44-47
18711142-2	2008	Here, we report that micromolar concentrations of the divalent cation Zn(2+) produce a 10-fold potentiation of NR1/NR3A receptor responses, which resembles that seen upon antagonizing glycine binding to the NR1 subunit.	Zinc	70-72	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	115-119
33969988-2	2021	Herein, the layered K0.36H0.26MnO2 0.28H2O (K36) with a proton and Zn2+ cointercalation mechanism leads to a progressive phase evolution from layer-type K36 to hybrid layer-type KxHyZnzMnO2 nH2O and spinel-type ZnMn2O4 nanocrystal after a long-term cycle.	Zinc	67-71	keratin 36	Homo sapiens	153-156
18711142-5	2008	Point mutations in the NR1 and NR3A glycine-binding sites revealed that both the potentiating and agonistic effects of Zn(2+) are mediated by the ligand-binding domain of the NR1 subunit.	Zinc	119-121	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	31-35
18711142-6	2008	In conclusion, Zn(2+) acts as a potent positive modulator and agonist at the NR1 subunit of NR1/NR3A receptors.	Zinc	15-17	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	96-100
18685026-5	2008	In contrast, cytosolic Zn(2+) increases were observed in CA1 neurons before ouabain-SD, and L-type channel block prevented the intracellular Zn(2+) rises.	Zinc	23-25	carbonic anhydrase 1	Mus musculus	57-60
33229261-7	2021	These results provide a possibility of increasing solubility of Zn in OPC clinker by increasing the contents of C3A and C4AF, thus will be very meaningful in the synthesis of OPC clinker by utilizing Zn-bearing alternative raw materials.	Zinc	64-66	complement C3	Homo sapiens	112-115
18606452-10	2008	Our results demonstrate the importance of the Zn-knuckle motif in EBF.	Zinc	46-48	EBF transcription factor 1	Homo sapiens	66-69
33755175-5	2021	Pigs fed the diet containing pharmacological Zn had increased (P < 0.05) ADG and G:F compared to the negative control and the 21% CP CWB diet.	Zinc	45-47	ADG	Sus scrofa	73-76
33755175-9	2021	Pigs fed 21% CP with Zn had increased (P = 0.001) ADG compared to those fed 18% CP (1.35% SID Lys) or 1.2% SID Lys.	Zinc	21-23	ADG	Sus scrofa	50-53
18588883-0	2008	Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.	Zinc	23-27	G protein-coupled receptor 39	Homo sapiens	67-72
33888834-0	2021	Rapid, quantitative, and high-sensitivity detection of anti-phospholipase A2 receptor antibodies using a novel CdSe/ZnS-based fluorescence immunosorbent assay.	Zinc	116-119	phospholipase A2 receptor 1	Homo sapiens	60-85
18588883-1	2008	Ala substitution of potential metal-ion binding residues in the main ligand-binding pocket of the Zn2+-activated G protein-coupled receptor 39 (GPR39) receptor did not decrease Zn2+ potency.	Zinc	98-102	G protein-coupled receptor 39	Homo sapiens	113-142
18588883-1	2008	Ala substitution of potential metal-ion binding residues in the main ligand-binding pocket of the Zn2+-activated G protein-coupled receptor 39 (GPR39) receptor did not decrease Zn2+ potency.	Zinc	98-102	G protein-coupled receptor 39	Homo sapiens	144-149
18588883-4	2008	It is proposed that Zn2+ acts as an agonist for GPR39, not in the classical manner by directly stabilizing an active conformation of the transmembrane domain, but instead by binding to His17 and His19 in the extracellular domain and potentially by diverting Asp313 from functioning as a tethered inverse agonist through engaging this residue in a tridentate metal-ion binding site.	Zinc	20-24	G protein-coupled receptor 39	Homo sapiens	48-53
18477665-8	2008	Zinc influx function of ZIP10 was demonstrated by (65)Zn transport assays in Xenopus oocyte expression experiments, suggesting that the inverse relationship between zinc availability and ZIP10 expression serves to maintain zinc homeostasis.	Zinc	54-56	solute carrier family 39 member 10	Danio rerio	24-29
33583176-0	2021	Detection of Kallikrein-Related Peptidase 4 with a Label-free Electrochemical Impedance Biosensor Based on a Zinc(II) Phthalocyanine Tetracarboxylic Acid-Functionalized Disposable Indium Tin Oxide Electrode.	Zinc	109-117	kallikrein related peptidase 4	Homo sapiens	13-43
20126369-8	2008	The results showed that in in vitro study, Zn-adequate group induced more VCAM-1 &amp; ICAM-1 mRNA expression than Zn-deficient group during 6-hour zinc treatment post-5 hour TNF-alpha treatment, unexpectedly.	Zinc	43-45	vascular cell adhesion molecule 1	Mus musculus	74-80
34057515-0	2021	Copper(II) and Zinc(II) Complexes Derived from N,N"-Bis(4-bromosalicylidene)propane-1,3-diamine: Syntheses, Crystal Structures and Antimicrobial Activity.	Zinc	15-23	Bis protein	Escherichia coli	52-55
33748704-3	2021	Here, we investigate the function of the appended Zn2+-binding domain (ZBD) in the bifunctional AARS, glutamyl-prolyl-tRNA synthetase (GluProRS).	Zinc	50-54	glutamyl-prolyl-tRNA synthetase	Mus musculus	102-133
18287486-5	2008	The type-4 MTs (MT4a and MT4b) conferred greater Zn tolerance and higher accumulation of Zn than other MTs to the Deltazrc1 Deltacot1 mutant.	Zinc	49-51	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	25-29
33673282-7	2021	Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone.	Zinc	90-94	8-oxoguanine DNA-glycosylase 1	Mus musculus	34-38
33673282-7	2021	Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone.	Zinc	135-139	8-oxoguanine DNA-glycosylase 1	Mus musculus	34-38
18287486-5	2008	The type-4 MTs (MT4a and MT4b) conferred greater Zn tolerance and higher accumulation of Zn than other MTs to the Deltazrc1 Deltacot1 mutant.	Zinc	89-91	Plant EC metallothionein-like protein, family 15	Arabidopsis thaliana	25-29
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	179-181	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	120-126
18359862-0	2008	Zn2+ binding to human calbindin D(28k) and the role of histidine residues.	Zinc	0-4	calbindin 1	Homo sapiens	22-31
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	179-181	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	131-137
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	215-217	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	120-126
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	215-217	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	131-137
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	237-241	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	120-126
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	237-241	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	131-137
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	215-217	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	120-126
33594269-4	2021	Here, we use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, function as Zn sensors by binding Zn2+ ions to a Zn-sensor motif.	Zinc	215-217	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	131-137
18359862-1	2008	We have studied the binding of Zn2+ to the hexa EF-hand protein, calbindin D(28k)-a strong Ca2+-binder involved in apoptosis regulation-which is highly expressed in brain tissue.	Zinc	31-35	calbindin 1	Homo sapiens	65-74
18359862-2	2008	By use of radioblots, isothermal titration calorimetry, and competition with a fluorescent Zn2+ chelator, we find that calbindin D(28k) binds Zn2+ to three rather strong sites with dissociation constants in the low micromolar range.	Zinc	91-95	calbindin 1	Homo sapiens	119-128
18359862-2	2008	By use of radioblots, isothermal titration calorimetry, and competition with a fluorescent Zn2+ chelator, we find that calbindin D(28k) binds Zn2+ to three rather strong sites with dissociation constants in the low micromolar range.	Zinc	142-146	calbindin 1	Homo sapiens	119-128
18359862-5	2008	The binding of Zn2+ is compatible with the ability of calbindin to activate myo-inositol monophosphatase, one of the known targets of calbindin.	Zinc	15-19	calbindin 1	Homo sapiens	54-63
18359862-5	2008	The binding of Zn2+ is compatible with the ability of calbindin to activate myo-inositol monophosphatase, one of the known targets of calbindin.	Zinc	15-19	calbindin 1	Homo sapiens	134-143
18203721-0	2008	Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity.	Zinc	56-58	zinc transporter	Arabidopsis thaliana	37-43
33169865-4	2021	We considered the complexes of the extended recognition site of a Zn-dependent metallo-beta-lactamase, VIM-2, produced by bacteria responsible for nosocomial infections, with five newly synthesized inhibitors sharing an original dizinc binding group, 1,2,4-triazole-3-thione (TZT).	Zinc	66-68	vimentin 2, pseudogene	Homo sapiens	103-108
32354246-2	2020	Zinc (Zn), selenium (Se), and glutathione (GSH) have antioxidant properties in several cells and hypoxia-induced TRPM2 channel activity, ROS and cell death may be inhibited by the Zn, Se, and GSH treatments.	Zinc	6-8	transient receptor potential cation channel subfamily M member 2	Homo sapiens	113-118
32354246-2	2020	Zinc (Zn), selenium (Se), and glutathione (GSH) have antioxidant properties in several cells and hypoxia-induced TRPM2 channel activity, ROS and cell death may be inhibited by the Zn, Se, and GSH treatments.	Zinc	180-182	transient receptor potential cation channel subfamily M member 2	Homo sapiens	113-118
18203721-8	2008	The K(m) for Zn(2+) and V(max) of AtMTP1 were determined to be 0.30 microm and 1.22 nmol/min/mg, respectively.	Zinc	13-15	zinc transporter	Arabidopsis thaliana	34-40
32354246-7	2020	Compared to the normoxia groups, the current densities of TRPM2 channel were increased in the hypoxia-exposed cells by the hypoxia applications, while the same values were decreased in the treatment of Zn, Se, and GSH according to hypoxia group.	Zinc	202-204	transient receptor potential cation channel subfamily M member 2	Homo sapiens	58-63
18335143-1	2008	In this paper we discuss the structural chemistry of (PPh(4))(2)M(WS(4))(2) (M = Co, Ni, Zn) materials.	Zinc	89-91	potassium two pore domain channel subfamily K member 3	Homo sapiens	54-60
32354246-8	2020	In conclusion, hypoxia-induced TRPM2 channel activity, ROS and cell death were recovered by the Se, Zn and GSH treatments.	Zinc	100-102	transient receptor potential cation channel subfamily M member 2	Homo sapiens	31-36
18088336-6	2008	The Arabidopsis myb72 knockout mutant was more sensitive to excess Zn or iron (Fe) deficiency than wild type, while Arabidopsis transformants overexpressing bHLH100 showed increased tolerance to high Zn and nickel (Ni) compared to wild-type plants, confirming their role in metal homeostasis in Arabidopsis.	Zinc	67-69	myb domain protein 72	Arabidopsis thaliana	16-21
33230284-8	2020	Our findings explain the mode-of-action of xanthine-based TRPC1/4/5 modulators, and suggest a structural basis for TRPC1/4/5 modulation by endogenous factors such as (phospho)lipids and Zn2+ ions.	Zinc	186-190	transient receptor potential cation channel subfamily C member 1	Homo sapiens	58-67
33230284-8	2020	Our findings explain the mode-of-action of xanthine-based TRPC1/4/5 modulators, and suggest a structural basis for TRPC1/4/5 modulation by endogenous factors such as (phospho)lipids and Zn2+ ions.	Zinc	186-190	transient receptor potential cation channel subfamily C member 1	Homo sapiens	115-124
18201832-4	2008	Consistent with the properties of gH+s in other cell types, the magnitude of the rise in pHi observed in the absence of external Ca2+ was not affected by the removal of external Na+ but was sensitive to external Zn2+ and temperature and was dependent on the measured transmembrane pH gradient (DeltapHmemb).	Zinc	212-216	glucose-6-phosphate isomerase	Rattus norvegicus	89-92
32873629-2	2020	Iron absorption in Arabidopsis root epidermal cells requires the IRT1 transporter that also allows the entry of certain non-iron metals, such as Zn, Mn, and Co.	Zinc	145-147	iron-regulated transporter 1	Arabidopsis thaliana	65-69
18479026-10	2008	The binding constants and sites of the interaction with SA were analyzed by the Scatchard"s equation, the results indicated that there was a strong interaction between the four metal complexes and serum albumin and the binding force was Co-GLUS &gt; Zn-GLUS &gt; Cu-GLUS &gt; Cu-GLUS, and the binding site is only one.	Zinc	250-252	albumin	Bos taurus	203-210
33060722-0	2020	A C-peptide complex with albumin and Zn2+ increases measurable GLUT1 levels in membranes of human red blood cells.	Zinc	37-41	solute carrier family 2 member 1	Homo sapiens	63-68
32977698-2	2020	Genetic inactivation of TRPM7 in animal models uncovered the critical role of TRPM7 in early embryonic development, immune responses, and the organismal balance of Zn2+, Mg2+, and Ca2+.	Zinc	164-168	transient receptor potential cation channel subfamily M member 7	Homo sapiens	24-29
32977698-2	2020	Genetic inactivation of TRPM7 in animal models uncovered the critical role of TRPM7 in early embryonic development, immune responses, and the organismal balance of Zn2+, Mg2+, and Ca2+.	Zinc	164-168	transient receptor potential cation channel subfamily M member 7	Homo sapiens	78-83
17935725-0	2008	One-pot synthesis of ZnS/polymer composites in supercritical CO2-ethanol solution and their applications in degradation of dyes.	Zinc	21-24	complement C2	Homo sapiens	61-64
18048453-4	2008	Here we investigate at the single-channel level the mechanism of high affinity Zn(2+) inhibition of recombinant NR1/NR2A receptors expressed in HEK293 cells.	Zinc	79-81	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	112-115
32800116-0	2020	Promotion effect of Zn on 2D bimetallic NiZn metal organic framework nanosheets for tyrosinase immobilization and ultrasensitive detection of phenol.	Zinc	20-22	tyrosinase	Homo sapiens	84-94
32800116-3	2020	Herein, 2D bimetallic metal organic framework nanosheets (NiZn-MOF NSs) with tunable Ni/Zn ratios were synthesized, and for the first time employed to construct a tyrosinase biosensor.	Zinc	60-62	tyrosinase	Homo sapiens	163-173
18048453-4	2008	Here we investigate at the single-channel level the mechanism of high affinity Zn(2+) inhibition of recombinant NR1/NR2A receptors expressed in HEK293 cells.	Zinc	79-81	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	116-120
32610223-6	2020	Exposure to high Zn altered the mRNA expression levels of specific zip transporters, with an increase in zip1 (at 3 dpf) and zip8 (at 5 dpf), and a decrease in zip4 (at 5 dpf).	Zinc	17-19	solute carrier family 39 member 8	Danio rerio	125-129
18037372-0	2008	Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.	Zinc	12-16	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	31-35
32346941-7	2020	ZN also rescued the ZnT3 loss-associated reduction of neurogenesis via elevation of IGF-1 and ERK/CREB activation.	Zinc	0-2	solute carrier family 30 (zinc transporter), member 3	Mus musculus	20-24
32346941-8	2020	Together, these findings reveal that ZnT3 plays a highly important role in maintaining adult hippocampal neurogenesis and supplementation by ZN has a beneficial effect on hippocampal neurogenesis, as well as providing a therapeutic target for enhanced neuroprotection and repair after injury as demonstrated by its ability to prevent aging-dependent cognitive decline in ZnT3-/- mice.	Zinc	141-143	solute carrier family 30 (zinc transporter), member 3	Mus musculus	371-375
18023887-2	2008	MT gene expression is induced by various heavy metal ions, and Zn(2+) is able to bind and activate a transcription factor associated with the MT gene that is known as the metal responsive element (MRE) binding transcription factor-1 (MTF-1).	Zinc	63-69	metal regulatory transcription factor 1	Oreochromis niloticus	234-239
32615471-3	2020	Under the mild acidic microenvironment of tumor, the nanoreactor will collapse to release GOx that triggers a catalytic cascade reaction in vivo, depleting glucose, etching AgNPs@MBN, and producing toxic H2O2, Ag+, and Zn2+ ions, all of which work together to inhibit tumor growth.	Zinc	219-223	hydroxyacid oxidase 1	Homo sapiens	90-93
18083072-9	2008	The inhibition of enzymatic activity of both f-PSA and T-PSA over a wide range of concentrations of Zn(2+) ions (10nM to 50 microM) was comparable.	Zinc	100-102	kallikrein related peptidase 3	Homo sapiens	47-50
32155551-8	2020	Our findings indicate Zn-Asp, especially Zn, enhances ISC activity to maintain the intestinal integrity by activating the Wnt/beta-catenin signaling, which sheds some light upon effective preventive strategies for intestinal injury induced by mycotoxin based on ISCs with exogenous zinc preparations in the proper drugs, health foods or qualified feed.	Zinc	22-24	catenin (cadherin associated protein), beta 1	Mus musculus	126-138
18533363-3	2008	Detailed studies have determined that the glyoxalase I from Escherichia coli, Neisseria meningitidis and Yersinia pestis are maximally activated by Ni2+ and Co2+, and are inactive with Zn2+, a situation quite different from the human glyoxalase I enzyme, which is activated by Zn2+.	Zinc	277-281	glyoxalase I	Homo sapiens	42-54
32637763-2	2020	Here, we report a series of binuclear double-stranded helicates synthesized from different combinations of pyridyl hydrazone-based multidentate ligands (H2 1, H2 2, H2 3) by increasing the methylene spacer and transition metals (Co, Ni, and Zn).	Zinc	241-243	A-kinase anchoring protein 5	Homo sapiens	153-157
31688305-7	2020	In addition, Zn levels were significantly correlated with homeostasis model assessment of insulin resistance (HOMA-IR) (r = -0.284, P &lt; 0.001), hyaluronic acid (r = -0.230, P &lt; 0.001), branched chain amino acid/tyrosine molar ratio (BTR) (r = 0.278, P &lt; 0.001), FIB-4 index (r = -0.238, P &lt; 0.001), and NAFLD fibrosis score (NFS) (r = -0.261, P &lt; 0.001).	Zinc	13-15	G protein-coupled receptor 148	Homo sapiens	239-242
18533363-4	2008	Recent studies on the Pseudomonas aeruginosa genome have led to the characterization of three different glyoxalase I enzymes, two of which follow a Ni2+/Co2+ activation profile and the third exhibits a human-like preference for Zn2+.	Zinc	228-232	glyoxalase I	Homo sapiens	104-116
18350886-1	2008	Degradation of 1,1- and 1,2-dichloroethane (1,1-DCA, 1,2-DCA) and carbon tetrachloride (CCl4) on Zn0 was investigated using compound specific isotope analysis (CSIA) to measure isotopic fractionation factors for chloroalkane degradation by hydrogenolysis, by alpha-elimination, and by beta-elimination.	Zinc	97-100	C-C motif chemokine ligand 4	Homo sapiens	88-92
32453778-3	2020	The first step towards the detoxification of MG is catalyzed by GLYI, a metalloenzyme that requires divalent metal ions (either Zn2+ as seen in eukaryotes or Ni2+ as in prokaryotes).	Zinc	128-132	glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein	Arabidopsis thaliana	64-68
32453778-8	2020	Further, lack in germination of Arabidopsis AtGLYI2 mutants in presence of exogenous MG indicates the direct involvement of Zn2+ dependent GLYI in MG detoxification, suggesting Zn2+ dependent GLYI as the main enzyme responsible for MG detoxification and salinity stress tolerance.	Zinc	124-128	glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein	Arabidopsis thaliana	139-143
18691669-3	2008	A Zn(II)-binding motif, distinct from the Fe-binding site, has been proposed in human MTf based on computer modelling studies.	Zinc	2-8	melanotransferrin	Homo sapiens	86-89
18691669-10	2008	The ability of MTf to bind Zn(II) was also investigated using CD which demonstrated that the single high-affinity Fe-binding site was distinct from a potential Zn(II)-binding site.	Zinc	27-33	melanotransferrin	Homo sapiens	15-18
32172853-5	2020	When used as colorimetric sensor for Zn2+ detection, the detection limit of CP was as low as 100 ppb, and the color change was distinguishable after testing with tap water.	Zinc	37-41	nuclear RNA export factor 1	Homo sapiens	162-165
17881354-5	2007	This study defined novel structural features of the matrilin-3 A-domain and identified a conformational change induced by the presence or the absence of Zn(2+).	Zinc	153-155	matrilin 3	Homo sapiens	52-62
32154705-6	2020	To this end, we designed and synthesized the first PA probe of Zn2+, namely, CR-1 for in situ ratiometric imaging of Zn2+ in deep tissue in vivo.	Zinc	63-67	complement receptor 2	Mus musculus	77-81
32154705-6	2020	To this end, we designed and synthesized the first PA probe of Zn2+, namely, CR-1 for in situ ratiometric imaging of Zn2+ in deep tissue in vivo.	Zinc	117-121	complement receptor 2	Mus musculus	77-81
31309446-8	2020	Furthermore, the ROS levels in the testes obviously increased after Zn-deficient mice were stimulated with CCl4, whereas reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) showed reduced activities.	Zinc	68-70	chemokine (C-C motif) ligand 4	Mus musculus	107-111
17918925-2	2007	Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition.	Zinc	20-28	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	7-10
32296107-8	2020	Intracellular free Zn2+, apoptosis, cell death, PARP-1, TRPM2 expression, caspase -3 and -9 levels are increased through activating TRPM2 in the SH-SY5Y cells exposed to the HYPX.	Zinc	19-23	transient receptor potential cation channel subfamily M member 2	Homo sapiens	132-137
17918925-2	2007	Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition.	Zinc	77-85	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	7-10
17918829-0	2007	Synthesis and structure of new compounds with Zn-Ga bonds: insertion of the gallium(I) bisimidinate Ga(DDP) into Zn-X (X = CH3, Cl) and the homoleptic complex cation [Zn(GaCp*)4]2+.	Zinc	46-48	translocase of inner mitochondrial membrane 8A	Homo sapiens	100-107
32123074-2	2020	In a Zn deficiency-promoted rat ESCC model with miR-31 up-regulation, cancer-associated inflammation, and a high ESCC burden following N-nitrosomethylbenzylamine (NMBA) exposure, systemic antimiR-31 delivery reduced ESCC incidence from 85 to 45% (P = 0.038) and miR-31 gene knockout abrogated development of ESCC (P = 1 x 10-6).	Zinc	5-7	microRNA 31	Rattus norvegicus	48-54
32123074-2	2020	In a Zn deficiency-promoted rat ESCC model with miR-31 up-regulation, cancer-associated inflammation, and a high ESCC burden following N-nitrosomethylbenzylamine (NMBA) exposure, systemic antimiR-31 delivery reduced ESCC incidence from 85 to 45% (P = 0.038) and miR-31 gene knockout abrogated development of ESCC (P = 1 x 10-6).	Zinc	5-7	microRNA 31	Rattus norvegicus	192-198
32123074-3	2020	Transcriptomics, genome sequencing, and metabolomics analyses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout.	Zinc	71-73	microRNA 31	Rattus norvegicus	140-146
32123074-7	2020	ESCC-free, Zn-deficient miR-31-/- rat esophagus displayed no genome instability and limited metabolic activity changes vs. the pronounced mutational burden and ESCC-associated metabolic changes of Zn-deficient wild-type rats.	Zinc	11-13	microRNA 31	Rattus norvegicus	24-30
31172426-10	2020	The MMP-2 and MMP-13 analyses showed that the expression of the high-Zn group was significantly higher than that of the normal group, indicating that Zn plays an important role in its expression.	Zinc	69-71	matrix metallopeptidase 2	Mus musculus	4-9
32080244-3	2020	The framework of ZIF-8 is disrupted by Cl2, which bonds with Zn either on the surface or by freely diffusing into the cage.	Zinc	61-63	endogenous retrovirus group W member 5	Homo sapiens	39-42
32075143-7	2020	There are a superexchange interaction and an indirect exchange interaction that is provided by the spin (and charge) itinerant carriers in a spin-polarized band situated in the vicinity of the Fermi level of the Fe-doped ZnO semiconductor.	Zinc	221-224	spindlin 1	Homo sapiens	141-145
31759136-4	2020	Vesicular zinc transporter-3 (ZnT3) knockout mice lacking releasable Zn2+ were more resistant to locomotor deficit and memory impairment of nigrostriatal dopamine (DA) denervation compared to wildtype littermates.	Zinc	69-73	solute carrier family 30 (zinc transporter), member 3	Mus musculus	10-28
31759136-4	2020	Vesicular zinc transporter-3 (ZnT3) knockout mice lacking releasable Zn2+ were more resistant to locomotor deficit and memory impairment of nigrostriatal dopamine (DA) denervation compared to wildtype littermates.	Zinc	69-73	solute carrier family 30 (zinc transporter), member 3	Mus musculus	30-34
31855420-4	2020	It displays an apparent selectivity ranking of Hg2+ > Ag+ >= Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Pb2+.	Zinc	79-83	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	47-50
31979155-0	2020	Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.	Zinc	27-31	solute carrier family 39 member 4	Homo sapiens	55-59
17673155-2	2007	To better determine the role of MT in interprotein metal transfer, we describe a procedure that uses stable isotopically enriched (67)Zn(7) metallothionein 2 ((67)Zn(7)-MT-2) to quantitatively determine the stoichiometry of transfer of Zn from the protein to a recipient apo-metalloenzyme, apo-carbonic anhydrase (apo-CA) by directly coupled ion exchange high-performance liquid chromatography inductively coupled plasma mass spectrometry.	Zinc	163-165	metallothionein 2A	Homo sapiens	140-157
17443687-8	2007	ICP-MS analyses reveal that Cdc25C is a Zn(2+)-binding metalloprotein, and that TPEN effectively strips Zn(2+) away from the enzyme.	Zinc	40-42	cell division cycle 25C	Homo sapiens	28-34
17443687-9	2007	Interestingly, although apo-Cdc25C (Zn(2+)-deficient) remains fully catalytically active, it is compromised in its ability to dephosphorylate and activate MPF/cdk1.	Zinc	36-42	cell division cycle 25C	Homo sapiens	28-34
17443687-9	2007	Interestingly, although apo-Cdc25C (Zn(2+)-deficient) remains fully catalytically active, it is compromised in its ability to dephosphorylate and activate MPF/cdk1.	Zinc	36-42	cyclin dependent kinase 1	Homo sapiens	159-163
17644060-4	2007	Residues in the second Zn-finger loop (Gln49, Arg52), which contribute to C-domain dimerization on DR1 response elements, proved essential to IGFBP-3 binding.	Zinc	23-25	insulin like growth factor binding protein 3	Homo sapiens	142-149
31979155-4	2020	Here, using live-cell fluorescent imaging of Zn2+ and H+, in cells expressing ZIP4, we set out to interrogate its function.	Zinc	45-49	solute carrier family 39 member 4	Homo sapiens	78-82
17993224-20	2007	In combining apoproteins or peptides synthesized from scratch for purposes of catalysing certain transformations, the map and numerical approaches might prove useful for the selection of central ions which are even more efficient than the "natural" ones, like for Co2+ in many Zn enzymes.	Zinc	277-279	complement C2	Homo sapiens	264-267
31979155-6	2020	In contrast, extracellular acidification stimulated ZIP4 dependent Zn2+ uptake.	Zinc	67-71	solute carrier family 39 member 4	Homo sapiens	52-56
31979155-7	2020	Furthermore, Zn2+ uptake was coupled to enhanced H+ influx in cells expressing ZIP4, thus indicating that ZIP4 is not acting as a pH regulated channel but rather as an H+ powered Zn2+ co-transporter.	Zinc	13-17	solute carrier family 39 member 4	Homo sapiens	79-83
31979155-7	2020	Furthermore, Zn2+ uptake was coupled to enhanced H+ influx in cells expressing ZIP4, thus indicating that ZIP4 is not acting as a pH regulated channel but rather as an H+ powered Zn2+ co-transporter.	Zinc	13-17	solute carrier family 39 member 4	Homo sapiens	106-110
31979155-7	2020	Furthermore, Zn2+ uptake was coupled to enhanced H+ influx in cells expressing ZIP4, thus indicating that ZIP4 is not acting as a pH regulated channel but rather as an H+ powered Zn2+ co-transporter.	Zinc	13-16	solute carrier family 39 member 4	Homo sapiens	79-83
31979155-7	2020	Furthermore, Zn2+ uptake was coupled to enhanced H+ influx in cells expressing ZIP4, thus indicating that ZIP4 is not acting as a pH regulated channel but rather as an H+ powered Zn2+ co-transporter.	Zinc	13-16	solute carrier family 39 member 4	Homo sapiens	106-110
31979155-8	2020	We further illustrate how this functional mechanism is affected by genetic variants in SLC39A4 that in turn lead to Acrodermatitis enteropathica, a rare condition of Zn2+ deficiency.	Zinc	166-169	solute carrier family 39 member 4	Homo sapiens	87-94
31782469-1	2020	Oxytocin is a peptide hormone with high affinity to both Zn2+ and Cu2+ ions compared to other metal ions.	Zinc	57-61	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
17680810-7	2007	The conformational change induced in semenogelin I by the binding of Zn(2+) may contribute to the ability of this protein to form a gel.	Zinc	69-71	semenogelin 1	Homo sapiens	37-50
17766394-6	2007	The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure.	Zinc	89-91	ubiquitin specific peptidase 33	Homo sapiens	112-117
17766394-6	2007	The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure.	Zinc	89-91	ubiquitin specific peptidase 33	Homo sapiens	118-122
17550234-0	2007	Novel Zn2+ coordination by the regulatory N-terminus metal binding domain of Arabidopsis thaliana Zn(2+)-ATPase HMA2.	Zinc	6-10	heavy metal atpase 2	Arabidopsis thaliana	112-116
31868740-5	2020	Angular-dependent X-ray absorption analyses at the O K-edge reveal enhanced surface-state contributions and asymmetric O 2p orbital occupations in the (000\bar 1)-terminated o-plane ZnO compound.	Zinc	182-185	immunoglobulin kappa variable 1D-39	Homo sapiens	119-123
17550234-5	2007	The isolated HMA2 N-MBD fragment binds a single Zn2+ (Kd 0.18 microM), Cd2+ (Kd 0.27 microM), or, with less affinity, Cu+ (Kd 13 microM).	Zinc	48-52	heavy metal atpase 2	Arabidopsis thaliana	13-17
31583423-3	2019	Clam age was significantly negatively correlated (p < 0.05) with soft tissue Zn concentrations.	Zinc	77-79	CLAM	Homo sapiens	0-4
17513107-0	2007	Design, synthesis, and binding studies of bidentate Zn-chelating peptidic inhibitors of glyoxalase-I.	Zinc	52-54	glyoxalase I	Homo sapiens	88-100
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	160-164	growth hormone receptor	Homo sapiens	126-129
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	160-164	growth hormone receptor	Homo sapiens	237-240
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	192-196	growth hormone receptor	Homo sapiens	126-129
31173363-5	2019	It was found that the phosphorylation levels of Janus kinase 2, signal transducers and activators of transcription 5/3/1, and GHR increased significantly under Zn2+ treatment, indicating that Zn2+ can enhance the signaling ability of GH/GHR.	Zinc	192-196	growth hormone receptor	Homo sapiens	237-240
31173363-6	2019	On this basis, we further explored how Zn2+ regulates the biological activity of GH/GHR.	Zinc	39-43	growth hormone receptor	Homo sapiens	84-87
17544408-0	2007	Contributions of Zn(II)-binding to the structural stability of endostatin.	Zinc	17-23	collagen type XVIII alpha 1 chain	Homo sapiens	63-73
31173363-7	2019	The results showed that downregulation and turnover of GHR changed under Zn2+ /pGH treatment.	Zinc	73-77	growth hormone receptor	Homo sapiens	55-58
31173363-8	2019	Zn2+ enhanced the membrane residence time of pGH/GHR and delayed GHR downregulation.	Zinc	0-4	growth hormone receptor	Homo sapiens	49-52
17544408-1	2007	Endostatin has a compact structure with a Zn(II)-binding site (His1, His3, His11, and Asp76) at the N-terminus.	Zinc	42-48	collagen type XVIII alpha 1 chain	Homo sapiens	0-10
31173363-8	2019	Zn2+ enhanced the membrane residence time of pGH/GHR and delayed GHR downregulation.	Zinc	0-4	growth hormone receptor	Homo sapiens	65-68
31173363-9	2019	Further investigation showed that the internalization dynamic of pGH/GHR was changed by Zn2+ , which prolonged the residence time of pGH/GHR in the cell membrane.	Zinc	88-92	growth hormone receptor	Homo sapiens	69-72
17544408-2	2007	In this study, the effects of Zn(II)-binding on the folding and stability of recombinant human endostatin were studied.	Zinc	30-36	collagen type XVIII alpha 1 chain	Homo sapiens	95-105
31173363-9	2019	Further investigation showed that the internalization dynamic of pGH/GHR was changed by Zn2+ , which prolonged the residence time of pGH/GHR in the cell membrane.	Zinc	88-92	growth hormone receptor	Homo sapiens	137-140
17544408-3	2007	The results show that Zn(II)-binding largely stabilizes the structure of endostatin at physiological pH.	Zinc	22-28	collagen type XVIII alpha 1 chain	Homo sapiens	73-83
17544408-4	2007	Under some proteolytic conditions, Zn(II)-binding also contributes to the integrity of the N-terminus of endostatin, which is critical for endostatin to maintain a stable structure.	Zinc	35-41	collagen type XVIII alpha 1 chain	Homo sapiens	105-115
31546432-0	2019	Green synthesis of fluorescent PEG-ZnS QDs encapsulated into Co-MOFs as an effective sensor for ultrasensitive detection of copper ions in tap water.	Zinc	35-38	nuclear RNA export factor 1	Homo sapiens	139-142
17544408-4	2007	Under some proteolytic conditions, Zn(II)-binding also contributes to the integrity of the N-terminus of endostatin, which is critical for endostatin to maintain a stable structure.	Zinc	35-41	collagen type XVIII alpha 1 chain	Homo sapiens	139-149
17544408-5	2007	Moreover, engineering an extra Zn(II)-binding peptide to the N-terminus of human endostatin makes this molecule more stable and cooperative in the presence of Zn(II).	Zinc	31-37	collagen type XVIII alpha 1 chain	Homo sapiens	81-91
17544408-5	2007	Moreover, engineering an extra Zn(II)-binding peptide to the N-terminus of human endostatin makes this molecule more stable and cooperative in the presence of Zn(II).	Zinc	159-165	collagen type XVIII alpha 1 chain	Homo sapiens	81-91
17381157-1	2007	In a neutral aqueous environment, a new ratiometric Cd2+ fluorescent sensor 1a can successfully discriminate Cd2+ from Zn2+ by undergoing two different internal charge transfer (ICT) processes, and the high selectivity of sensor 1a to Cd2+ over some other metals was also observed.	Zinc	119-123	CD2 molecule	Homo sapiens	52-55
31738003-6	2019	KLF4 (Kruppel-like factor 4) is a Zn2+ -binding gene that plays a vital role in cell proliferation and differentiation.	Zinc	34-38	Kruppel like factor 4	Homo sapiens	0-4
31738003-6	2019	KLF4 (Kruppel-like factor 4) is a Zn2+ -binding gene that plays a vital role in cell proliferation and differentiation.	Zinc	34-38	Kruppel like factor 4	Homo sapiens	6-27
31738003-7	2019	Sustained Zn2+ release and the increased expression of KLF4 can be detected, suggesting that ZnO NRs have efficiently released Zn2+ for stemness maintenance.	Zinc	93-96	Kruppel like factor 4	Homo sapiens	55-59
31738003-7	2019	Sustained Zn2+ release and the increased expression of KLF4 can be detected, suggesting that ZnO NRs have efficiently released Zn2+ for stemness maintenance.	Zinc	127-131	Kruppel like factor 4	Homo sapiens	55-59
17317328-11	2007	Expression levels of cormorant MT1/2 showed significant positive correlations with hepatic Cu and Zn concentrations, suggesting that both MT isoforms were induced by Cu and Zn in livers.	Zinc	98-100	metallothionein 1I, pseudogene	Homo sapiens	31-36
31763072-4	2019	Twenty-six SOD genes were identified from the whole genome of wheat, including 17 Cu/Zn-SODs, six Fe-SODs, and three Mn-SODs.	Zinc	85-87	SOD	Triticum aestivum	11-14
17317328-11	2007	Expression levels of cormorant MT1/2 showed significant positive correlations with hepatic Cu and Zn concentrations, suggesting that both MT isoforms were induced by Cu and Zn in livers.	Zinc	173-175	metallothionein 1I, pseudogene	Homo sapiens	31-36
17374673-7	2007	Zn supplementation of ZD dams led to enhanced lymphocyte proliferation and IFN-gamma responses in pups ZDZ+.	Zinc	0-2	interferon gamma	Rattus norvegicus	75-84
31505452-0	2019	A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling.	Zinc	23-27	histone deacetylase 9	Homo sapiens	59-63
31592647-2	2019	Two bioenzymes, glucose oxidase (GOx) and alkaline phosphatase (ALP) were chosen for the enzymatic preparation of core-satellite or core-shell type CdSe/ZnS@Au hybrid nanostructures.	Zinc	153-156	hydroxyacid oxidase 1	Homo sapiens	16-31
31592647-2	2019	Two bioenzymes, glucose oxidase (GOx) and alkaline phosphatase (ALP) were chosen for the enzymatic preparation of core-satellite or core-shell type CdSe/ZnS@Au hybrid nanostructures.	Zinc	153-156	hydroxyacid oxidase 1	Homo sapiens	33-36
31666761-5	2019	We show that these shallow trap states are removed when additional wide band gap ZnS shells are grown around the CdSe/CdS core/shell QDs.	Zinc	81-84	TRAP	Homo sapiens	27-31
31396753-3	2019	Titers at this Zn concentration in CDM containing the insulin replacing agent aurintricarboxylic acid (ATA) (CDM + A) showed a 1.8-fold (EPO) and 1.2-fold (IgG) titers increase compared to control.	Zinc	15-17	erythropoietin	Cricetulus griseus	137-140
31136861-2	2019	DSH exhibited a highly selective and sensitive toward Zn2+ ions by "turn-on" response based on generation of monomer-excimer mechanism in aqueous solutions, and the detection limit was calculated at 11.2 nM.	Zinc	54-58	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	0-3
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Zinc	96-100	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	10-13
31136861-4	2019	Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn2+ ions and Na2EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.	Zinc	96-100	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	227-230
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	146-148	ATPase cation transporting 13A2	Homo sapiens	95-102
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	146-148	ATPase cation transporting 13A2	Homo sapiens	104-109
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	171-173	ATPase cation transporting 13A2	Homo sapiens	95-102
31345364-6	2019	Young and middle-aged deletion mutants of catp-6 and pdr-1, which are orthologues of mammalian ATP13A2 (PARK9) and parkin (PARK2), showed altered Zn homeostasis following Zn exposure compared to wildtype worms.	Zinc	171-173	ATPase cation transporting 13A2	Homo sapiens	104-109
31330099-9	2019	Finally, we demonstrate induction of PGRN expression by fast-on/fast-off, highly potent, macrocyclic HDAC inhibitors with ethyl ketone or ethyl ester Zn2+ binding groups.	Zinc	150-154	histone deacetylase 9	Homo sapiens	101-105
31035130-5	2019	Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) &gt; Ca(II) &gt; Co(II) &gt; Zn(II).	Zinc	135-141	carbonic anhydrase 2	Homo sapiens	111-117
31175919-8	2019	The endopolyphosphatase activities of Ppn2 and Ppn1 were induced by 0.01 mM of Co2+ or Zn2+, whereas that of Ddp1 required 0.1 mM of these cations.	Zinc	87-91	endopolyphosphatase	Saccharomyces cerevisiae S288C	47-51
17346081-4	2007	In particular, the reaction strongly depends on structural parameters (protecting group pattern, configuration at C-4) and on the presence of Zn2+ ions.	Zinc	142-146	complement C4A (Rodgers blood group)	Homo sapiens	114-117
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	91-93	peptidoglycan recognition protein 1	Homo sapiens	41-49
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	91-93	peptidoglycan recognition protein 3	Homo sapiens	51-59
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	91-93	peptidoglycan recognition protein 3	Homo sapiens	75-83
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	199-201	peptidoglycan recognition protein 1	Homo sapiens	41-49
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	199-201	peptidoglycan recognition protein 3	Homo sapiens	51-59
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	199-201	peptidoglycan recognition protein 3	Homo sapiens	75-83
17253189-5	2007	The binding of Sg-II to PSA and PCI is influenced by pH, ionic strength, heparin, negatively charged dextran sulfate, divalent cations, and particularly by Zn 2 +.	Zinc	156-162	semenogelin 2	Homo sapiens	15-20
17253189-5	2007	The binding of Sg-II to PSA and PCI is influenced by pH, ionic strength, heparin, negatively charged dextran sulfate, divalent cations, and particularly by Zn 2 +.	Zinc	156-162	kallikrein related peptidase 3	Homo sapiens	24-27
17143923-4	2007	Each of these Zn(II) complexes features a tetrahedral metal ion bound to the three amino arms of ligand 1 and to an exogenous ligand (either HO-, X-, or RNH2) sitting outside of the cavity.	Zinc	14-20	NLR family pyrin domain containing 4	Homo sapiens	153-157
31203897-0	2019	Phloem-specific overexpression of AtOPT6 in Arabidopsis enhances Zn transport into shoots.	Zinc	65-67	oligopeptide transporter 1	Arabidopsis thaliana	34-40
31203897-7	2019	The results of heavy metal analysis revealed that transgenic Arabidopsis overexpressing AtOPT6 under the control of pSUC2 could promote the transport of Zn into shoots as effectively as transgenic Arabidopsis with elevated foliar GSH synthesis, or wild-type plants with exogenous foliar application of GSH.	Zinc	153-155	oligopeptide transporter 1	Arabidopsis thaliana	88-94
17163970-3	2007	Its overexpression prevents the deleterious effects exhibited by CUP1-CRS5-null cells when exposed to combined Zn/Cu, as it does the mouse MT1 Zn-thionein, but not Cup1.	Zinc	111-113	metallothionein CUP1	Saccharomyces cerevisiae S288C	65-69
17163970-3	2007	Its overexpression prevents the deleterious effects exhibited by CUP1-CRS5-null cells when exposed to combined Zn/Cu, as it does the mouse MT1 Zn-thionein, but not Cup1.	Zinc	111-113	CRS5	Saccharomyces cerevisiae S288C	70-74
17335495-4	2007	* In the hma2, hma4 double mutant, which is deficient in root to shoot Zn translocation, Zinpyr-1 fluorescence was low in the xylem and high in the adjacent pericycle cells in which HMA2 and HMA4 are specifically expressed in a wild type.	Zinc	71-73	heavy metal atpase 2	Arabidopsis thaliana	9-13
17136261-1	2006	Complexation of linear hexaoxime ligand H6L with Zn2+ and Mn+ (= La3+, Ba2+) afforded a tetranuclear single metallohelicate [LZn3M]n+, whose inversion rate can be modulated by the central metal Mn+.	Zinc	49-53	H6 family homeobox 2	Homo sapiens	40-43
17158957-6	2006	Previously, we showed that UNC-97 interacts with UNC-98, a 37-kD protein, containing four C2H2 Zn fingers, that localizes to M-lines.	Zinc	95-97	Zinc finger protein unc-98	Caenorhabditis elegans	49-55
17046817-9	2006	The sequestration of Zn(2+) ions from the N-terminal fibrinogen-binding region abrogated decorin incorporation into the fibrin network.	Zinc	21-23	decorin	Homo sapiens	89-96
17052688-6	2006	Interestingly, Zn(tanm)(2) increased depressed plasma adiponectin levels in the mice.	Zinc	15-17	adiponectin, C1Q and collagen domain containing	Mus musculus	54-65
17054911-10	2006	We could activate GPR39 by high concentrations of Zn(2+), demonstrating cell surface expression of a functional receptor that could elicit a Ca(2+) response.	Zinc	50-52	G protein-coupled receptor 39	Homo sapiens	18-23
17013754-1	2006	The effect of Zn on p53-independent cell death was examined in IIC9 embryonic fibroblasts.	Zinc	14-16	cellular tumor antigen p53	Cricetulus griseus	20-23
16839579-8	2006	Both ZN-1 and ZN-2 blocked estradiol stimulation of c-Myc and cyclin D1 gene expression in MCF-7 cells, two events that are clearly coupled to cell cycle progression.	Zinc	14-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	52-57
16981707-4	2006	Thus, a new mechanism is proposed in which the active site-bound Fe2+ or Zn2+ serves as a Lewis acid to activate the 2-OH group of (S)-HPP and the epoxide ring is formed by the attack of the 2-OH group at C-1 coupled with the transfer of the C-1 hydrogen as a hydride ion to the bound FMN.	Zinc	73-77	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	205-208
16981707-4	2006	Thus, a new mechanism is proposed in which the active site-bound Fe2+ or Zn2+ serves as a Lewis acid to activate the 2-OH group of (S)-HPP and the epoxide ring is formed by the attack of the 2-OH group at C-1 coupled with the transfer of the C-1 hydrogen as a hydride ion to the bound FMN.	Zinc	73-77	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	242-245
16922547-6	2006	DNA attachment to BGR surfaces was strong enough to allow AFM imaging when the deposition buffer contained one of the following cations: Co(II), Mg(II), Mn(II), Ni(II), and Zn(II).	Zinc	173-175	C-type lectin domain containing 7A	Homo sapiens	18-21
16772659-4	2006	DAZAP1 is detected exclusively in the nucleus and has the ability to shuttle between the nucleus and the cytoplasm using a highly conserved 25 amino acid segment, designated ZNS, at its C terminus.	Zinc	174-177	DAZ associated protein 1	Homo sapiens	0-6
16582407-2	2006	These proteins bind Zn(2+) and act as substrates for prostate-specific antigen and transglutaminase.	Zinc	20-22	kallikrein related peptidase 3	Homo sapiens	53-78
16564629-6	2006	A model of the average structure in the space group P6(3)/mmc with assumed composition Mg(2)Zn(5-x)Al(2+x), have been derived by Patterson analysis and intensity comparisons.	Zinc	92-94	tumor protein p63	Homo sapiens	52-57
16563532-6	2006	After Zn and Zn + Cu exposure the expression of MT-1 and MT-2 isoforms increased with a concomitant increase in MT synthesis.	Zinc	6-8	metallothionein 1I, pseudogene	Homo sapiens	48-61
31241327-1	2019	Tartrate (Tar2-) was originally employed in this work as a chelating/structure-directing agent for hydrothermal crystallization of ZnWO4, where the decisive roles of Tar2-/Zn2+/WO42- molar ratio, solution pH (7-10), and the use of ethylene glycol (EG) cosolvent in phase/morphology evolution were deciphered in detail.	Zinc	172-175	trace amine associated receptor 2	Homo sapiens	10-14
16563532-6	2006	After Zn and Zn + Cu exposure the expression of MT-1 and MT-2 isoforms increased with a concomitant increase in MT synthesis.	Zinc	13-15	metallothionein 1I, pseudogene	Homo sapiens	48-61
16488017-3	2006	Data obtained at pH 7.0 using this system, show that the synthetic ionophore transports divalent cations with the selectivity sequence Pb2+ &gt; Cd2+ &gt;&gt; Zn2+ &gt; Mn2+ &gt; Co2+ &gt; Ni2+ &gt; Ca2+ &gt; Sr2+.	Zinc	159-163	CD2 molecule	Homo sapiens	145-148
31243558-7	2019	The mineralization and ALP activity was higher for polycaprolactone membranes modified with Zn doped bioglass than compared to pure PCL membranes or control material.	Zinc	92-94	ATHS	Homo sapiens	23-26
30833508-4	2019	We show that MF input-induced Zn2+ signaling inhibits postsynaptic PTP, and thus enables MF inputs to induce LTP-IE at a wide range of [Ca2+]i values.	Zinc	30-34	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	67-70
30833508-4	2019	We show that MF input-induced Zn2+ signaling inhibits postsynaptic PTP, and thus enables MF inputs to induce LTP-IE at a wide range of [Ca2+]i values.	Zinc	30-34	carbonic anhydrase 2	Homo sapiens	136-139
30833508-6	2019	Moreover, the incompetence of somatic stimulation was rescued by the inhibition of PTP or a supplement of extracellular zinc, indicating that MF input-induced increase in dendritic [Zn2+] facilitates the induction of LTP-IE by inhibiting PTP.	Zinc	182-186	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	83-86
30833508-6	2019	Moreover, the incompetence of somatic stimulation was rescued by the inhibition of PTP or a supplement of extracellular zinc, indicating that MF input-induced increase in dendritic [Zn2+] facilitates the induction of LTP-IE by inhibiting PTP.	Zinc	182-186	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	238-241
30690405-5	2019	Secondly, Zn pre-exposure reduced Cd accumulation at 100 and 200 mug/L Cd, down-regulated il-6 and il-1beta at 100 mug/L Cd and p65 at 200 mug/L Cd, and increased Cu/Zn-SOD and CAT activities at 200 mug/L Cd.	Zinc	10-12	interleukin 6 (interferon, beta 2)	Danio rerio	90-94
30690405-6	2019	Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent manner.	Zinc	9-11	metal-regulatory transcription factor 1	Danio rerio	83-88
16474894-6	2006	The stability constants of complexes formed with Gd3+, Cu2+ and Zn2+ increase with an increase in the number of butyl substituents in the order ML(0) &lt; ML(1) &lt; ML(2).	Zinc	64-68	GRDX	Homo sapiens	49-52
30778144-5	2019	Two zinc-finger-like motifs are present in each NS1 monomer, and tubules are disrupted by divalent cation chelation and restored by cation addition, including Zn2+, suggesting a regulatory role of divalent cations in tubule formation.	Zinc	159-163	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	48-51
30668786-12	2019	As main effect, birds supplemented with organic Zn had higher mRNA expression of TLR-2 (P = 0.02) and IgA (P = 0.01).	Zinc	48-50	toll-like receptor 2 type-1	Gallus gallus	81-86
30957488-9	2019	We discuss how the additional conformational changes introduced to these domains upon Zn2+ binding may also impact the interaction of S100A12 and target proteins such as RAGE.	Zinc	86-90	advanced glycosylation end-product specific receptor	Homo sapiens	170-174
16474894-13	2006	The rates of the proton, Cu2+ and Zn2+ assisted dissociation of Gd3+ complexes decrease with increasing number of the n-butyl substituents, which is presumably the result of steric hindrance hampering the formation or dissociation of the intermediates.	Zinc	34-38	GRDX	Homo sapiens	64-67
16330433-4	2005	The U937/PR9 subclone, whose expression of PML-RARalpha protein can be induced by Zn2+, was also investigated.	Zinc	82-86	PML nuclear body scaffold	Homo sapiens	43-46
30823346-7	2019	Fifty percent of the genes differentially expressed in the ZnSO4 treatment, including the three metal responsive genes (mtl-1, mtl-2 and numr-1), were shared among all treatments, suggesting that responses to all forms of Zn could be partially attributed to dissolved Zn.	Zinc	59-61	Metallothionein-2	Caenorhabditis elegans	127-132
16330433-4	2005	The U937/PR9 subclone, whose expression of PML-RARalpha protein can be induced by Zn2+, was also investigated.	Zinc	82-86	retinoic acid receptor alpha	Homo sapiens	47-55
30823346-7	2019	Fifty percent of the genes differentially expressed in the ZnSO4 treatment, including the three metal responsive genes (mtl-1, mtl-2 and numr-1), were shared among all treatments, suggesting that responses to all forms of Zn could be partially attributed to dissolved Zn.	Zinc	59-61	NUclear localized Metal Responsive	Caenorhabditis elegans	137-143
16853635-3	2005	In the most stable Zn-MOR structures Zn(2+) is located in a small ring (5MR, 6MR) containing two Al/Si substitutions.	Zinc	19-21	opioid receptor mu 1	Homo sapiens	22-25
30823346-7	2019	Fifty percent of the genes differentially expressed in the ZnSO4 treatment, including the three metal responsive genes (mtl-1, mtl-2 and numr-1), were shared among all treatments, suggesting that responses to all forms of Zn could be partially attributed to dissolved Zn.	Zinc	222-224	NUclear localized Metal Responsive	Caenorhabditis elegans	137-143
30229906-1	2019	Transient receptor potential melastatin 2 (TRPM2) channel activation by reactive oxygen species (ROS) plays a critical role in delayed neuronal cell death, responsible for postischemia brain damage via altering intracellular Zn2+ homeostasis, but a mechanistic understanding is still lacking.	Zinc	225-229	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-41
16853635-3	2005	In the most stable Zn-MOR structures Zn(2+) is located in a small ring (5MR, 6MR) containing two Al/Si substitutions.	Zinc	37-39	opioid receptor mu 1	Homo sapiens	22-25
30229906-1	2019	Transient receptor potential melastatin 2 (TRPM2) channel activation by reactive oxygen species (ROS) plays a critical role in delayed neuronal cell death, responsible for postischemia brain damage via altering intracellular Zn2+ homeostasis, but a mechanistic understanding is still lacking.	Zinc	225-229	transient receptor potential cation channel subfamily M member 2	Homo sapiens	43-48
30229906-5	2019	Bafilomycin-induced lysosomal dysfunction also resulted in mitochondrial Zn2+ accumulation, fragmentation, and ROS generation that were inhibited by PJ34 or 2-APB, suggesting that these mitochondrial events are TRPM2 dependent and sequela of lysosomal dysfunction.	Zinc	73-77	transient receptor potential cation channel subfamily M member 2	Homo sapiens	211-216
15980035-0	2005	p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.	Zinc	113-117	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	55-84
30229906-6	2019	Mitochondrial TRPM2 expression was detected and exposure to ADPR-induced Zn2+ uptake in isolated mitochondria, which was prevented by TPEN.	Zinc	73-77	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
15980035-5	2005	Inhibitors of the phosphatidylinositol 3-kinase (PI3K) potently block Zn2+-induced COX-2 mRNA and protein expression.	Zinc	70-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	18-47
30229906-9	2019	Collectively, these results support a critical role for the TRPM2 channel in coupling PKC/NOX-mediated ROS generation, lysosomal Zn2+ release, and mitochondrial Zn2+ accumulation, and ROS generation to form a vicious positive feedback signaling mechanism for ROS-induced delayed cell death.	Zinc	129-133	transient receptor potential cation channel subfamily M member 2	Homo sapiens	60-65
30229906-9	2019	Collectively, these results support a critical role for the TRPM2 channel in coupling PKC/NOX-mediated ROS generation, lysosomal Zn2+ release, and mitochondrial Zn2+ accumulation, and ROS generation to form a vicious positive feedback signaling mechanism for ROS-induced delayed cell death.	Zinc	161-165	transient receptor potential cation channel subfamily M member 2	Homo sapiens	60-65
16041076-8	2005	The overall folding of the present structure is essentially similar to that of the monoferric C-terminal lobe of bovine lactoferrin, although it contains Zn2+ in place of Fe3+ in the metal-binding cleft as well as two additional Zn2+ ions on the surface of the C-terminal lobe.	Zinc	154-158	lactotransferrin	Bos taurus	120-131
30783936-8	2019	The changing levels of As, Zn and Se seems to affect the severity of inflammatory reactions based on IL-6, IL-10 and TNF-alpha levels (r = 0.755, r = 0.679 and r = 0.617, respectively, for all p &lt; 0.01).	Zinc	27-29	interleukin 10	Homo sapiens	107-112
16041076-8	2005	The overall folding of the present structure is essentially similar to that of the monoferric C-terminal lobe of bovine lactoferrin, although it contains Zn2+ in place of Fe3+ in the metal-binding cleft as well as two additional Zn2+ ions on the surface of the C-terminal lobe.	Zinc	229-233	lactotransferrin	Bos taurus	120-131
16041076-13	2005	The structure shows that the C-terminal lobe of lactoferrin is capable of sequestering a Zn2+ ion at a pH of 3.8.	Zinc	89-93	lactotransferrin	Bos taurus	48-59
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	45-47	NPHS1 adhesion molecule, nephrin	Homo sapiens	18-26
15990634-10	2005	Liver IGF-I and IGFBP-3 mRNA levels were higher in low Zn animals compared with controls.	Zinc	55-57	insulin-like growth factor 1	Rattus norvegicus	6-11
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	45-47	NPHS1 adhesion molecule, nephrin	Homo sapiens	23-26
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	169-171	NPHS1 adhesion molecule, nephrin	Homo sapiens	18-26
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	169-171	NPHS1 adhesion molecule, nephrin	Homo sapiens	23-26
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	169-171	NPHS1 adhesion molecule, nephrin	Homo sapiens	18-26
30793878-4	2019	The free-standing Co2P@CNF air-cathode-based Zn-air batteries deliver a power density of 121 mW cm-2 at a voltage of 0.76 V. The overall overpotential of Co2P@CNF-based Zn-air batteries can be significantly reduced, with low discharge-charge voltage gap (0.81 V at 10 mA cm-2) and high cycling stability, which outperform the benchmark Pt/C-based Zn-air batteries.	Zinc	169-171	NPHS1 adhesion molecule, nephrin	Homo sapiens	23-26
30628789-3	2019	GLO1 is a Zn2+-dependent enzyme that isomerizes a hemithioacetal, formed from glutathione and methylglyoxal, to a lactic acid thioester.	Zinc	10-14	glyoxalase 1	Mus musculus	0-4
30253258-5	2019	Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1beta, tnf-alpha and inos.	Zinc	12-14	interleukin 6 (interferon, beta 2)	Danio rerio	132-136
30460652-10	2019	For chocolates, the Emperor had the highest Pb:Zn (0.50) ratios and Trident had the highest Cd:Zn (0.57) ratios.	Zinc	95-97	forkhead box M1	Homo sapiens	68-75
31588059-10	2019	Results of microarray analysis revealed significant changes in gene expression of transthyretin and many olfactory receptors in the hippocampus of Zn-treated mice.	Zinc	147-149	transthyretin	Mus musculus	82-95
29307859-4	2019	Since we recently have shown how hyperglycemia (HG)-induced changes in ZIP7 and ZnT7 contribute to Zn2+-transport across S(E)R and contribute to S(E)R-stress in the heart, herein, we hypothesized that these transporters can also be localized to mitochondria and affect the S(E)R-mitochondria coupling, and thereby contribute to cellular Zn2+-muffling between S(E)R-mitochondria in HG-cells.	Zinc	99-103	solute carrier family 30 member 7	Homo sapiens	80-84
29307859-9	2019	Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and S(E)R and contribute to cellular Zn2+-muffling between cellular-compartments in HG or hypertrophic cardiomyocytes via affecting S(E)R-mitochondria coupling.	Zinc	155-159	solute carrier family 30 member 7	Homo sapiens	81-85
30466585-2	2018	Orthologous proteins AtMTP5 and AtMTP12 from Arabidopsis have also been shown to form a heterodimeric complex at the Golgi compartment of plant cells that possibly transport Zn.	Zinc	174-176	Cation efflux family protein	Arabidopsis thaliana	21-27
30357199-1	2018	Copper transfer from Cu(ii)amyloid-beta4-16 to human Zn7-metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA.	Zinc	53-55	metallothionein 3	Homo sapiens	57-74
30357199-1	2018	Copper transfer from Cu(ii)amyloid-beta4-16 to human Zn7-metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA.	Zinc	53-55	metallothionein 3	Homo sapiens	138-155
30145429-4	2018	Transient changes in Zn2+ concentrations within the cell or in the extracellular region occur following its release from Zn2+ binding metallothioneins, its transport across membranes by the ZnT or ZIP transporters, or release of vesicular Zn2+.	Zinc	21-25	death associated protein kinase 3	Homo sapiens	197-200
30206119-4	2018	We unexpectedly found here that the CARD in CARD9 binds to Zn2+ with picomolar affinity-a concentration comparable with the levels of readily accessible Zn2+ in the cytosol.	Zinc	59-63	caspase recruitment domain family member 9	Homo sapiens	44-49
30206119-4	2018	We unexpectedly found here that the CARD in CARD9 binds to Zn2+ with picomolar affinity-a concentration comparable with the levels of readily accessible Zn2+ in the cytosol.	Zinc	153-157	caspase recruitment domain family member 9	Homo sapiens	44-49
30206119-5	2018	NMR solution structures of the CARD9-CARD in the apo and Zn2+-bound states revealed that Zn2+ has little effect on the ground-state structure of the CARD; yet the stability of the domain increased considerably upon Zn2+ binding, with a concomitant reduction in conformational flexibility.	Zinc	57-61	caspase recruitment domain family member 9	Homo sapiens	31-36
30206119-5	2018	NMR solution structures of the CARD9-CARD in the apo and Zn2+-bound states revealed that Zn2+ has little effect on the ground-state structure of the CARD; yet the stability of the domain increased considerably upon Zn2+ binding, with a concomitant reduction in conformational flexibility.	Zinc	89-93	caspase recruitment domain family member 9	Homo sapiens	31-36
30206119-5	2018	NMR solution structures of the CARD9-CARD in the apo and Zn2+-bound states revealed that Zn2+ has little effect on the ground-state structure of the CARD; yet the stability of the domain increased considerably upon Zn2+ binding, with a concomitant reduction in conformational flexibility.	Zinc	89-93	caspase recruitment domain family member 9	Homo sapiens	31-36
30206119-6	2018	Moreover, Zn2+ binding inhibited polymerization of the CARD9-CARD into helical assemblies.	Zinc	10-14	caspase recruitment domain family member 9	Homo sapiens	55-60
30206119-9	2018	Our findings indicate that CARD9 is a potential target of Zn2+-mediated signaling that affects Bcl10 polymerization in innate immune responses.	Zinc	58-62	caspase recruitment domain family member 9	Homo sapiens	27-32
30208271-0	2018	The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.	Zinc	77-81	mutY DNA glycosylase	Homo sapiens	54-59
30208271-5	2018	We recently uncovered a second functionally relevant metal cofactor site present only in higher eukaryotic MUTYH orthologs: a Zn2+ ion coordinated by three Cys residues located within the extended interdomain connector (IDC) region of MUTYH that connects the N-terminal adenine excision and C-terminal 8-oxoG recognition domains.	Zinc	126-130	mutY DNA glycosylase	Homo sapiens	107-112
30208271-5	2018	We recently uncovered a second functionally relevant metal cofactor site present only in higher eukaryotic MUTYH orthologs: a Zn2+ ion coordinated by three Cys residues located within the extended interdomain connector (IDC) region of MUTYH that connects the N-terminal adenine excision and C-terminal 8-oxoG recognition domains.	Zinc	126-130	mutY DNA glycosylase	Homo sapiens	235-240
29499210-6	2018	[125I]T3 binding to wild type TTR and mutant TTRDelta3-11, was differentially modulated by Zn2+.	Zinc	91-95	transthyretin	Homo sapiens	30-33
29499210-7	2018	Zn2+ contents of wild type TTR were 7-10/TTR (mol/mol).	Zinc	0-4	transthyretin	Homo sapiens	27-30
29499210-7	2018	Zn2+ contents of wild type TTR were 7-10/TTR (mol/mol).	Zinc	0-4	transthyretin	Homo sapiens	41-44
29895356-7	2018	The increased Fe areal density was found in all examined hippocampal areas whilst Zn was elevated in CA3, DG and H. In order to follow the dynamics of age-dependent elemental changes, the statistical significance of differences in their accumulation between subsequent moments of time was examined.	Zinc	82-84	carbonic anhydrase 3	Rattus norvegicus	101-104
29890505-10	2018	QuantiGene (QDP) RNA analysis revealed Cd to be a potent inducer of metallothionein 2 (mt2) mRNA in zebrafish larvae, and Zn to be a weak mt2 inducer, suggesting a protective role of mt2 in Cd and Zn olfactory injury.	Zinc	122-124	metallothionein 2	Danio rerio	138-141
29890505-10	2018	QuantiGene (QDP) RNA analysis revealed Cd to be a potent inducer of metallothionein 2 (mt2) mRNA in zebrafish larvae, and Zn to be a weak mt2 inducer, suggesting a protective role of mt2 in Cd and Zn olfactory injury.	Zinc	122-124	metallothionein 2	Danio rerio	138-141
29596989-8	2018	The rAp activity was significantly inhibited by PMSF, Zn2+ and Fe2+ and the rAp had a broad substrate specificity for natural proteins and synthetic peptide substrates, and preferred substrates at P1 position with large hydrophobic side-chain groups.	Zinc	54-58	LDL receptor related protein associated protein 1	Rattus norvegicus	4-7
29596989-8	2018	The rAp activity was significantly inhibited by PMSF, Zn2+ and Fe2+ and the rAp had a broad substrate specificity for natural proteins and synthetic peptide substrates, and preferred substrates at P1 position with large hydrophobic side-chain groups.	Zinc	54-58	LDL receptor related protein associated protein 1	Rattus norvegicus	8-9
15990634-10	2005	Liver IGF-I and IGFBP-3 mRNA levels were higher in low Zn animals compared with controls.	Zinc	55-57	insulin-like growth factor binding protein 3	Rattus norvegicus	16-23
15952772-0	2005	Identification of a Cd2+- and Zn2+-binding site in cytochrome c using FTIR coupled to an ATR microdialysis setup and NMR spectroscopy.	Zinc	30-34	cytochrome c, somatic	Equus caballus	51-63
29752522-4	2018	Bean biofortification breeding programs develop new varieties with high levels of Fe and Zn targeted for countries with human micronutrient deficiencies.	Zinc	89-91	brain expressed associated with NEDD4 1	Homo sapiens	0-4
30197701-13	2018	Conclusion: We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.	Zinc	38-42	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	98-104
30197701-13	2018	Conclusion: We have demonstrated that Zn2+ differentially modulates two CaV3 channels (Cav3.2 and Cav3.3): It is a preferential blocker of CaV3.2 channels and it alters the gating behaviour of CaV3.3 channels.	Zinc	38-42	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	193-199
15952772-0	2005	Identification of a Cd2+- and Zn2+-binding site in cytochrome c using FTIR coupled to an ATR microdialysis setup and NMR spectroscopy.	Zinc	30-34	ATR serine/threonine kinase	Equus caballus	89-92
29991716-3	2018	As one of the underlying mechanisms of Cu, Zn superoxide dismutase (SOD1) gene mutation-induced ALS, SOD1 mutants (SOD1mut) commonly interact with an endoplasmic reticulum-resident membrane protein Derlin-1, triggering motoneuron death.	Zinc	43-45	Der1-like domain family, member 1	Mus musculus	198-206
15952772-4	2005	In this study, we identified a Cd(2+)- or Zn(2+)-binding site in cytochrome c with dissociation constants of 17 and 42 microM, respectively, which affects the oxidation rate of ferrocytochrome c by hydrogen peroxide.	Zinc	42-48	cytochrome c, somatic	Equus caballus	65-77
29198021-9	2018	Zn treatment caused neurobehavioral anomalies, striatal dopamine decline, and dopaminergic neuronal cell loss accompanied with a marked increase in alpha-synuclein expression/aggregation and Ubiquitin-conjugated protein levels in the exposed groups.	Zinc	0-2	synuclein alpha	Rattus norvegicus	148-163
15917084-4	2005	Mn(2+), Co(2+), and Mg(2+)-dependent autophosphorylation of MST3 is mainly on threonine residue while Zn(2+)-stimulated MST3 autophosphorylation is on both serine and threonine residues.	Zinc	102-108	serine/threonine kinase 24	Homo sapiens	60-64
29198021-12	2018	The results suggest that Zn caused UPS impairment, resulting in alpha-synuclein aggregation subsequently leading to dopaminergic neurodegeneration, and that Zn-induced Parkinsonism exhibited positive L-Dopa response similar to sporadic PD.	Zinc	25-27	synuclein alpha	Rattus norvegicus	64-79
15917084-4	2005	Mn(2+), Co(2+), and Mg(2+)-dependent autophosphorylation of MST3 is mainly on threonine residue while Zn(2+)-stimulated MST3 autophosphorylation is on both serine and threonine residues.	Zinc	102-108	serine/threonine kinase 24	Homo sapiens	120-124
15753101-10	2005	Taken together, our investigations support an involvement of AtYSL2 in Fe and Zn homeostasis, although functionality or substrate specificity are likely to differ between AtYSL2 and ZmYS1.	Zinc	78-80	YELLOW STRIPE like 2	Arabidopsis thaliana	61-67
29873380-6	2018	The resultant 8-17 DNAzyme fragments may bind with the loop of Hp2 to form a partial double-stranded DNA (dsDNA) duplex, initiating the cyclic cleavage of Hp2 in the presence of Zn2+-dependent DNAzymes and generating numerous new DNA fragments with the free 3"-OH terminal, which can induce the formation of a poly(thymine) (poly-T) sequence with the assistance of terminal deoxynucleotidyl transferase (TdTase).	Zinc	178-182	DNA nucleotidylexotransferase	Homo sapiens	365-402
29873380-6	2018	The resultant 8-17 DNAzyme fragments may bind with the loop of Hp2 to form a partial double-stranded DNA (dsDNA) duplex, initiating the cyclic cleavage of Hp2 in the presence of Zn2+-dependent DNAzymes and generating numerous new DNA fragments with the free 3"-OH terminal, which can induce the formation of a poly(thymine) (poly-T) sequence with the assistance of terminal deoxynucleotidyl transferase (TdTase).	Zinc	178-182	DNA nucleotidylexotransferase	Homo sapiens	404-410
15820896-4	2005	Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center.	Zinc	95-99	secreted phosphoprotein 1	Homo sapiens	39-43
29058176-3	2018	The activation/phosphorylation of some proteins including Zn2+-transporter ZIP7 in cardiomyocytes is controlled with CK2alpha, thereby, inducing changes in the level of intracellular free Zn2+ ([Zn2+] i ).	Zinc	58-62	casein kinase 2 alpha 2	Homo sapiens	117-125
15820896-4	2005	Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center.	Zinc	95-99	secreted phosphoprotein 1	Homo sapiens	49-53
15802852-0	2005	In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.	Zinc	48-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
29737340-2	2018	It is found that solute atoms Mg and Zn are likely to segregate to the Sigma5(210)[001] tilt Al GB.	Zinc	37-39	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	71-77
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	Zinc	48-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
29658693-4	2018	In the presence of HCl, the ZnO NPs would convert into Zn2+ to open the PZF because Zn2+ can specifically react with zinc finger peptide to destroy the PZF structure forming abundant pores.	Zinc	55-59	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	72-75
29658693-4	2018	In the presence of HCl, the ZnO NPs would convert into Zn2+ to open the PZF because Zn2+ can specifically react with zinc finger peptide to destroy the PZF structure forming abundant pores.	Zinc	55-59	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	152-155
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	Zinc	166-172	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15865262-7	2005	Interestingly, Zn treatment to protein-deficient animals lowered already raised activity catalase, glutathione peroxidase, and glutathione-S-transferase and levels of lipid peroxidation to significant levels when compared to protein-deficient animals.	Zinc	15-17	hematopoietic prostaglandin D synthase	Rattus norvegicus	127-152
15655791-1	2005	Electrospray ionization mass spectra of some glycosyl dithioacetals recorded in the presence of transition-metal chlorides, XCl2 (where X = Co, Mn and Zn), give abundant adduct ions such as [M+XCl]+ and [2M-H+X]+ and minor ions such as [M-H+X]+ and [2M+XCl]+.	Zinc	151-153	X-C motif chemokine ligand 2	Homo sapiens	124-128
29658693-4	2018	In the presence of HCl, the ZnO NPs would convert into Zn2+ to open the PZF because Zn2+ can specifically react with zinc finger peptide to destroy the PZF structure forming abundant pores.	Zinc	84-88	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	72-75
29658693-4	2018	In the presence of HCl, the ZnO NPs would convert into Zn2+ to open the PZF because Zn2+ can specifically react with zinc finger peptide to destroy the PZF structure forming abundant pores.	Zinc	84-88	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	152-155
29658693-5	2018	In this way, Zn2+ could act as the key of Raman signal to open the PZF structure obtaining a strong Raman signal of TB.	Zinc	13-17	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	67-70
15341838-3	2004	The adsorption of Zn2+ is speeded up by the presence of Cd2+ and Hg2+ ions provided that the concentration of these two ions is high as compared to the concentration of Zn2+.	Zinc	18-22	CD2 molecule	Homo sapiens	56-59
29492773-5	2018	The ability of these metal ions to produce oligosaccharide adduct ions by ESI had the general trend: Ca(II) &gt; Mg(II) &gt; Ni(II) &gt; Co(II) &gt; Zn(II) &gt; Cu(II) &gt; Na(I) &gt; K(I) &gt; Al(III)   Fe(III)   Cr(III).	Zinc	149-151	carbonic anhydrase 2	Homo sapiens	101-107
15341838-3	2004	The adsorption of Zn2+ is speeded up by the presence of Cd2+ and Hg2+ ions provided that the concentration of these two ions is high as compared to the concentration of Zn2+.	Zinc	169-173	CD2 molecule	Homo sapiens	56-59
15178055-2	2004	Stable isotopically labeled (67)Zn(3)Cd(4) MTII was used to enable Zn donated from MTII to be differentiated from extraneous sources of Zn.	Zinc	32-34	metallothionein 2A	Homo sapiens	83-87
29577622-6	2018	Finally, the rechargeable Zn-air battery assembled from the optimized catalyst (CNF@Zn/CoNC) displays a peak power density of 140.1 mW cm-2 , energy density of 878.9 Wh kgZn-1 , and excellent cyclic stability over 150 h, giving a promising performance in realistic application.	Zinc	26-28	NPHS1 adhesion molecule, nephrin	Homo sapiens	80-83
29548726-6	2018	Under Cd exposure, we noted an overexpression of the genes coding for membrane transporter involved in the intracellular incorporation of Zn (ZIP6) associated with inhibition of that encoding the transporters involved in the output of the Zn into the extracellular medium (ZnT1 and ZnT3).	Zinc	138-140	solute carrier family 39 member 6	Rattus norvegicus	142-146
15178055-2	2004	Stable isotopically labeled (67)Zn(3)Cd(4) MTII was used to enable Zn donated from MTII to be differentiated from extraneous sources of Zn.	Zinc	67-69	metallothionein 2A	Homo sapiens	43-47
15178055-2	2004	Stable isotopically labeled (67)Zn(3)Cd(4) MTII was used to enable Zn donated from MTII to be differentiated from extraneous sources of Zn.	Zinc	67-69	metallothionein 2A	Homo sapiens	83-87
29485857-6	2018	In IMP-1, binding does not replace the nucleophilic hydroxide, and the PMPC carboxylate and pyridine nitrogen interact closely (2.3 and 2.7 A, respectively) with the Zn2 ion of the binuclear metal site.	Zinc	166-169	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	3-8
15178055-3	2004	Transfer of both (67)Zn and Cd from MTII to apo-carbonic anhydrase was noted in the absence of either GSSG or GSH.	Zinc	21-23	metallothionein 2A	Homo sapiens	36-40
15178055-5	2004	Thereafter, a gradual increase in the (67)Zn content at the expense of Cd was noted over 24-h indicating continued interaction and exchange between MTII and the enzyme commensurate with the relative preferences shown by the proteins for these two metals.	Zinc	42-44	metallothionein 2A	Homo sapiens	148-152
15145943-4	2004	Our results indicate that external Zn(2+) rapidly and reversibly activates ENaC in a dose-dependent manner with an estimated EC(50) of 2 microm.	Zinc	35-37	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	75-79
32704689-17	2018	2, EO did not affect ADG or ADFI, whereas pharmacological levels of Cu, Zn, and CTC increased (P < 0.05) ADG with coinciding increases (P = 0.055, 0.006, and linear 0.079, respectively) in ADFI.	Zinc	72-74	ADG	Sus scrofa	105-108
32704689-19	2018	Overall from d 5 to 47, Cu increased (P = 0.018) ADG, Zn increased (P < 0.05) ADG and ADFI, and EO tended to decrease (P = 0.086) G:F. In conclusion, increased dietary Cu, Zn, or CTC improved weanling pig performance while EO elicited no growth benefits.	Zinc	54-56	ADG	Sus scrofa	78-81
29545819-3	2018	Investigation of the natural variation in leaf Zn content in a world-wide collection of 349 Arabidopsis thaliana wild collected accessions identified two accessions, Van-0 and Fab-2, which accumulate significantly lower Zn when compared with Col-0.	Zinc	47-49	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	176-181
29545819-3	2018	Investigation of the natural variation in leaf Zn content in a world-wide collection of 349 Arabidopsis thaliana wild collected accessions identified two accessions, Van-0 and Fab-2, which accumulate significantly lower Zn when compared with Col-0.	Zinc	220-222	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	176-181
29545819-6	2018	Sequence analysis revealed that a 1-bp deletion in the third exon of HMA4 from Fab-2 is responsible for the lose of function of HMA4 driving the low Zn observed in Fab-2.	Zinc	149-151	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	79-84
15145943-9	2004	Our results suggest that external Zn(2+) activates ENaC by relieving the channel from Na(+) self-inhibition, and that external Ni(2+) mimics or masks Na(+) self-inhibition.	Zinc	34-36	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
29545819-6	2018	Sequence analysis revealed that a 1-bp deletion in the third exon of HMA4 from Fab-2 is responsible for the lose of function of HMA4 driving the low Zn observed in Fab-2.	Zinc	149-151	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	164-169
29545819-9	2018	In addition, we also observed that Fab-2, Van-0 and the hma4-2 null mutant in the Col-0 background show enhanced resistance to a combination of high Zn and high Cd in the growth medium, raising the possibility that variation at HMA4 may play a role in environmental adaptation.	Zinc	149-151	Plant stearoyl-acyl-carrier-protein desaturase family protein	Arabidopsis thaliana	35-40
15233916-2	2004	A step in this selective injury is Ca(2+) and/or Zn(2+) entry through Ca(2+)-permeable AMPA receptor channels; reducing Ca(2+) permeability of AMPA receptors via expression of Ca(2+)-impermeable GluR2(R) channels or activation of CRE transcription in the hippocampus of adult rats in vivo using shutoff-deficient pSFV-based vectors rescues vulnerable CA1 pyramidal neurons from forebrain ischemic injury.	Zinc	49-55	carbonic anhydrase 1	Rattus norvegicus	351-354
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	50-54	solute carrier family 6 member 9 L homeolog	Xenopus laevis	84-89
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	163-167	solute carrier family 6 member 9 L homeolog	Xenopus laevis	84-89
15031290-5	2004	We have also investigated the molecular basis for these differences and the relationship between the Zn2+ and proton binding sites on GLYT1.	Zinc	101-105	solute carrier family 6 member 9 L homeolog	Xenopus laevis	134-139
14648120-10	2004	However, the ability of RIT1 to facilitate Zn and Cd uptake when these metals are present at elevated concentrations suggests that RIT1 may be one pathway for the entry of toxic metals into the food chain.	Zinc	43-45	tRNA A64-2'-O-ribosylphosphate transferase	Saccharomyces cerevisiae S288C	24-28
29476070-1	2018	SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells.	Zinc	24-26	solute carrier family 30 member 2	Homo sapiens	0-7
29476070-1	2018	SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells.	Zinc	24-26	solute carrier family 30 member 2	Homo sapiens	41-45
14556652-2	2004	Unlike other GlxI enzymes, Escherichia coli GlxI exhibits no activity with Zn(2+) but maximal activation with Ni(2+).	Zinc	75-77	glyoxalase I	Homo sapiens	44-48
29476070-2	2018	Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants are associated with abnormally low milk Zn levels and can lead to severe infantile Zn deficiency.	Zinc	50-52	solute carrier family 30 member 2	Homo sapiens	112-116
14556652-8	2004	One of the ligands to the catalytic metal, His(5), was altered to glutamine, a side chain found in the Zn(2+)-active Homo sapiens GlxI.	Zinc	103-105	glyoxalase I	Homo sapiens	130-134
29453864-6	2018	Finally, we show that in Zn deficient conditions loss of function of LPCAT1 increases the phospholipid Lyso-PhosphatidylCholine/PhosphatidylCholine ratio, the expression of the Pi transporter PHT1;1, and that this leads to shoot Pi accumulation.	Zinc	25-27	lysophosphatidylcholine acyltransferase 1	Homo sapiens	69-75
14556652-10	2004	However, low levels of activity were now observed for Zn(2+)-bound GlxI.	Zinc	54-60	glyoxalase I	Homo sapiens	67-71
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
29416015-7	2018	Bafilomycin-induced lysosomal dysfunction also resulted in TRPM2-dependent cytosolic Zn2+ increase, mitochondrial Zn2+ accumulation, and mitochondrial generation of ROS, supporting that lysosomal dysfunction and accompanying Zn2+ release trigger mitochondrial Zn2+ accumulation and generation of ROS.	Zinc	85-89	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	59-64
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-5	2004	The photoluminescence efficiency of the resulting composite particle film of ZnS-passivated CdS was significantly enhanced as compared to that of the plain CdS film, due to the effective passivation of surface electronic states of CdS by ZnS, a material with a higher conduction band than that of CdS.	Zinc	77-80	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
28950204-2	2018	Under low Zn concentration (0.1mgL-1), the nitrification rate was promoted by Zn ions and inhibited by the two NPs, indicating that the toxicity of NPs was caused by the NPs themselves instead of the released Zn ions.	Zinc	10-12	LLGL scribble cell polarity complex component 1	Homo sapiens	31-36
15745020-5	2004	The photoluminescence efficiency of the resulting composite particle film of ZnS-passivated CdS was significantly enhanced as compared to that of the plain CdS film, due to the effective passivation of surface electronic states of CdS by ZnS, a material with a higher conduction band than that of CdS.	Zinc	77-80	CDP-diacylglycerol synthase 1	Homo sapiens	156-159
15745020-5	2004	The photoluminescence efficiency of the resulting composite particle film of ZnS-passivated CdS was significantly enhanced as compared to that of the plain CdS film, due to the effective passivation of surface electronic states of CdS by ZnS, a material with a higher conduction band than that of CdS.	Zinc	77-80	CDP-diacylglycerol synthase 1	Homo sapiens	156-159
15745020-5	2004	The photoluminescence efficiency of the resulting composite particle film of ZnS-passivated CdS was significantly enhanced as compared to that of the plain CdS film, due to the effective passivation of surface electronic states of CdS by ZnS, a material with a higher conduction band than that of CdS.	Zinc	77-80	CDP-diacylglycerol synthase 1	Homo sapiens	156-159
15745020-5	2004	The photoluminescence efficiency of the resulting composite particle film of ZnS-passivated CdS was significantly enhanced as compared to that of the plain CdS film, due to the effective passivation of surface electronic states of CdS by ZnS, a material with a higher conduction band than that of CdS.	Zinc	238-241	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
15745020-6	2004	As for particle films of CdS-modified ZnS, a decay in photoluminescence efficiency was observed.	Zinc	38-41	CDP-diacylglycerol synthase 1	Homo sapiens	25-28
30270320-2	2018	The movement of Zn in and out of cells, across membranes, is regulated by two protein families: the zinc-regulated transporter (ZRT), iron-regulated transporter (IRT)-like protein (ZIP) and the Zn transporter (ZnT) families.	Zinc	16-18	death associated protein kinase 3	Homo sapiens	181-184
15120848-3	2004	We report here the real time observation of increase of the concentration of extracellular Zn(2+) ([Zn(2+)](o)), accompanied by a rapid increase of intracellular free Zn(2+)concentration, in the areas of dentate gyrus (DG), CA1 and CA3 in acute rat hippocampus slices during ischemia simulated by deprivation of oxygen and glucose (OGD) followed by reperfusion with normal artificial cerebrospinal fluid.	Zinc	91-93	carbonic anhydrase 1	Rattus norvegicus	224-227
15120848-3	2004	We report here the real time observation of increase of the concentration of extracellular Zn(2+) ([Zn(2+)](o)), accompanied by a rapid increase of intracellular free Zn(2+)concentration, in the areas of dentate gyrus (DG), CA1 and CA3 in acute rat hippocampus slices during ischemia simulated by deprivation of oxygen and glucose (OGD) followed by reperfusion with normal artificial cerebrospinal fluid.	Zinc	100-102	carbonic anhydrase 1	Rattus norvegicus	224-227
28928244-6	2018	Fluorescence live cell imaging revealed that extracellular Zn2+ exerted rapid inhibitory effects on Orai1-mediated SOCE and on intracellular Ca2+ oscillations in the ESCC cells.	Zinc	59-63	ORAI calcium release-activated calcium modulator 1	Homo sapiens	100-105
14643239-0	2003	Dithiol-mediated incorporation of CdS nanoparticles from reverse micellar system into Zn-doped SBA-15 mesoporous silica and their photocatalytic properties.	Zinc	86-88	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
29727262-3	2018	From sequence alignments, a structurally conserved Zn-binding domain common to class I and class II aaRS was identified.	Zinc	51-53	alanyl-tRNA synthetase 1	Homo sapiens	100-104
14643239-1	2003	CdS nanoparticles, as prepared in reverse micellar systems, were incorporated into alkanedithiol-modified Zn-doped SBA-15 mesoporous silica (dtz.sbnd;ZnSBA-15; pore diameter, ca.	Zinc	106-108	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
14643239-6	2003	This is effected by electron transfer from the photoexcited ZnS (dithiol-bonded Zn on SBA-15) to CdS nanoparticles.	Zinc	60-62	CDP-diacylglycerol synthase 1	Homo sapiens	97-100
29114036-4	2017	The vesicular zinc (Zn2+) transporter ZnT2 is critical for appropriate mammary gland architecture, and ZnT2 deletion is associated with cytoplasmic Zn2+ accumulation, loss of secretory function and lactation failure.	Zinc	20-24	solute carrier family 30 member 2	Homo sapiens	38-42
29114036-5	2017	The underlying mechanisms are important to understand as numerous mutations and non-synonymous genetic variation in ZnT2 have been detected in women that result in severe Zn2+ deficiency in exclusively breastfed infants.	Zinc	171-175	solute carrier family 30 member 2	Homo sapiens	116-120
14622981-7	2003	These findings suggest that AA and SVCT2 mediate Zn-induced OPN and OCN expression and partly regulate Zn-induced osteoblastic differentiation.	Zinc	49-51	secreted phosphoprotein 1	Homo sapiens	60-63
29056506-3	2017	In the present study, we show that Zn2+ has a higher affinity for binding to CN2 than Mn2+, as evidenced by native mass spectrometry.	Zinc	35-39	carnosine dipeptidase 2	Homo sapiens	77-80
14581177-0	2003	Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions.	Zinc	115-119	pyrimidinergic receptor P2Y4	Rattus norvegicus	54-58
14566968-8	2003	In contrast, Zn(2+) increases the affinity by which either [(125)I]-IGF-I or [(125)I]-R(3)-IGF-I binds to the IGF-1R, but depresses [(125)I]-IGF-II binding to the IGF-type 2 receptor (IGF-2R) on BC(3)H-1 cells.	Zinc	13-15	insulin-like growth factor 2	Mus musculus	141-147
29311807-0	2017	Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death.	Zinc	28-32	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	60-65
14552638-4	2003	Reactions of L1 and L2 with M(hfac)(2) (hfac = 1,1,1,5,5,5-hexafluoroacetylacetonate, M = Mn, Ni, Cu, Zn) produce 2:1 complexes (L)(2).M(hfac)(2) with cis and trans configurations, respectively.	Zinc	102-104	CYFIP related Rac1 interactor B	Homo sapiens	13-15
14515014-2	2003	Herein, we describe the mechanism by which zinc (Zn2+) maintains IGF-II in an active form by directly regulating IGF-II binding to IGF-binding proteins (IGFBPs) and the type 1 IGF receptor (IGF-1R).	Zinc	49-53	insulin like growth factor 2	Homo sapiens	65-71
28409411-9	2017	Furthermore, supplementing Zn increased the activities of catalase and glutathione peroxidase in the jejunal mucosa (P &lt; 0.05), which were accompanied with increased malondialdehyde levels (P &lt; 0.05) in the broilers.	Zinc	27-29	catalase	Gallus gallus	58-66
14515014-2	2003	Herein, we describe the mechanism by which zinc (Zn2+) maintains IGF-II in an active form by directly regulating IGF-II binding to IGF-binding proteins (IGFBPs) and the type 1 IGF receptor (IGF-1R).	Zinc	49-53	insulin like growth factor 2	Homo sapiens	113-119
28753206-0	2017	TRPM2-mediated rise in mitochondrial Zn2+ promotes palmitate-induced mitochondrial fission and pancreatic beta-cell death in rodents.	Zinc	37-41	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
14515014-2	2003	Herein, we describe the mechanism by which zinc (Zn2+) maintains IGF-II in an active form by directly regulating IGF-II binding to IGF-binding proteins (IGFBPs) and the type 1 IGF receptor (IGF-1R).	Zinc	49-53	insulin like growth factor binding protein 3	Homo sapiens	153-159
28753206-6	2017	Although TRPM2 activation affects the intracellular dynamics of Ca2+ and Zn2+, chelation of Zn2+ alone was sufficient to prevent mitochondrial fission.	Zinc	73-77	transient receptor potential cation channel subfamily M member 2	Homo sapiens	9-14
28753206-12	2017	The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn2+, Drp-1 recruitment and abnormal mitochondrial fission.	Zinc	108-112	cytochrome b-245 beta chain	Homo sapiens	21-26
14515014-5	2003	Zn2+, Cd2+, and Au3+, but not La3+, decreased total binding and the affinity for [125I]IGF-II association with IGFBP-3 and IGFBP-5.	Zinc	0-4	insulin like growth factor 2	Homo sapiens	87-93
14515014-5	2003	Zn2+, Cd2+, and Au3+, but not La3+, decreased total binding and the affinity for [125I]IGF-II association with IGFBP-3 and IGFBP-5.	Zinc	0-4	insulin like growth factor binding protein 3	Homo sapiens	111-118
14515014-7	2003	In contrast, Zn2+ enhanced [125I]IGF-II binding to the IGF-1R by enhancing the rate of ligand association and decreasing the rate of dissociation.	Zinc	13-17	insulin like growth factor 2	Homo sapiens	33-39
14515014-9	2003	Together with the current work, these findings imply that Zn2+ acts in vivo to prevent secreted IGF-II from binding to IGFBP-3 and IGFBP- 5, thus maintaining IGF-II in an "active state," i.e., readily available for IGF-1R association.	Zinc	58-62	insulin like growth factor 2	Homo sapiens	96-102
27459881-8	2017	HSP70 +1267 AA genotype was an independent factor associated with Zn plasma concentrations.	Zinc	66-68	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
14515014-9	2003	Together with the current work, these findings imply that Zn2+ acts in vivo to prevent secreted IGF-II from binding to IGFBP-3 and IGFBP- 5, thus maintaining IGF-II in an "active state," i.e., readily available for IGF-1R association.	Zinc	58-62	insulin like growth factor binding protein 3	Homo sapiens	119-126
14515014-9	2003	Together with the current work, these findings imply that Zn2+ acts in vivo to prevent secreted IGF-II from binding to IGFBP-3 and IGFBP- 5, thus maintaining IGF-II in an "active state," i.e., readily available for IGF-1R association.	Zinc	58-62	insulin like growth factor 2	Homo sapiens	158-164
28965604-3	2017	Previous work had indicated a Zn2+-dependent upregulation of STAT1 mRNA in response to LPS and IFN-beta, potentially affecting STAT1-dependent downstream signaling upon pre-incubation with these agents.	Zinc	30-34	signal transducer and activator of transcription 1	Homo sapiens	61-66
28965604-3	2017	Previous work had indicated a Zn2+-dependent upregulation of STAT1 mRNA in response to LPS and IFN-beta, potentially affecting STAT1-dependent downstream signaling upon pre-incubation with these agents.	Zinc	30-34	signal transducer and activator of transcription 1	Homo sapiens	127-132
12582160-0	2003	Decorin binds fibrinogen in a Zn2+-dependent interaction.	Zinc	30-34	decorin	Homo sapiens	0-7
28965604-4	2017	The aim of the present study was to investigate the long-term influence of Zn2+ chelation on cellular STAT1 levels and their effect on protein levels and activity of iNOS.	Zinc	75-79	signal transducer and activator of transcription 1	Homo sapiens	102-107
28965604-5	2017	The LPS- and IFN-beta-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn2+ with the membrane permeable chelator N,N,N",N"-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.	Zinc	103-107	signal transducer and activator of transcription 1	Homo sapiens	43-48
28965604-8	2017	In conclusion, long term Zn2+ chelation does affect STAT1 protein expression, but interferes with NO production by a different, yet unknown pathway not involving STAT1.	Zinc	25-29	signal transducer and activator of transcription 1	Homo sapiens	52-57
28965604-8	2017	In conclusion, long term Zn2+ chelation does affect STAT1 protein expression, but interferes with NO production by a different, yet unknown pathway not involving STAT1.	Zinc	25-29	signal transducer and activator of transcription 1	Homo sapiens	162-167
12582160-1	2003	We have previously shown that decorin, a member of the small leucine-rich proteoglycan family of extracellular matrix proteoglycans/glycoproteins is a Zn(2+) metalloprotein at physiological Zn(2+) concentrations (Yang, V. W-C., LaBrenz, S. R., Rosenberg, L. C., McQuillan, D., and Hook, M. (1999) J. Biol.	Zinc	151-153	decorin	Homo sapiens	30-37
12582160-4	2003	We now report that the decorin proteoglycan binds fibrinogen in the presence of Zn(2+).	Zinc	80-82	decorin	Homo sapiens	23-30
12582160-6	2003	Furthermore, we show that Zn(2+) promotes the self-association of decorin.	Zinc	26-28	decorin	Homo sapiens	66-73
12582160-8	2003	The results of solid-phase binding assays and gel filtration chromatography suggest that the N-terminal domain of decorin, when present at low micromolar concentrations, forms an oligomer in a Zn(2+)-dependent manner.	Zinc	193-195	decorin	Homo sapiens	114-121
12689772-2	2003	Recently, evidence has been gathered to suggest that Abeta precipitation and toxicity in AD are caused by abnormal interactions with neocortical metal ions, especially Zn, Cu and Fe.	Zinc	168-170	amyloid beta (A4) precursor protein	Mus musculus	53-58
28235370-0	2017	Low-Temperature PLD-Growth of Ultrathin ZnO Nanowires by Using Zn x Al1-x O and Zn x Ga1-x O Seed Layers.	Zinc	40-42	ephrin A5	Homo sapiens	68-71
28235370-0	2017	Low-Temperature PLD-Growth of Ultrathin ZnO Nanowires by Using Zn x Al1-x O and Zn x Ga1-x O Seed Layers.	Zinc	63-65	ephrin A5	Homo sapiens	68-71
12616630-4	2003	Here, we report the synthesis and UV and NMR spectroscopic structural characterization of a 37 amino acid SUPERMAN region complexed to a Zn(2+) ion (Zn-SUP37) and present the first high-resolution structure of a classical zinc finger domain from a plant protein.	Zinc	137-139	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	106-114
28868809-5	2017	The Fe3+ -containing oxides showed band-gap narrowing (owing to strong sp-d exchange interactions between Zn2+ and the transition-metal ion), and this tuned the color of these materials uniquely.	Zinc	106-110	surfactant protein D	Homo sapiens	71-75
12531252-5	2003	Tests of fast- and slow-binding inhibitions showed that fatty acid synthase of chicken liver is rapidly and irreversibly inactivated by low Zn(2+) concentrations.	Zinc	140-142	fatty acid synthase	Gallus gallus	56-75
29245902-3	2017	Specifically, we initially found that high level of Zn2+ upregulates the expression of COX-2 via stimulating the activity of TNF-alpha in a zinc transporter 3 (ZnT3)-dependent mechanism.	Zinc	52-56	solute carrier family 30 (zinc transporter), member 3	Mus musculus	140-158
29245902-3	2017	Specifically, we initially found that high level of Zn2+ upregulates the expression of COX-2 via stimulating the activity of TNF-alpha in a zinc transporter 3 (ZnT3)-dependent mechanism.	Zinc	52-56	solute carrier family 30 (zinc transporter), member 3	Mus musculus	160-164
28747335-11	2017	There was a Zn2+-induced increase in the functional component of NADPH oxidase, p47phox, thus suggesting that NADPH oxidase may mediate Zn2+-induced ROS accumulation.	Zinc	12-16	neutrophil cytosolic factor 1	Homo sapiens	80-87
28747335-11	2017	There was a Zn2+-induced increase in the functional component of NADPH oxidase, p47phox, thus suggesting that NADPH oxidase may mediate Zn2+-induced ROS accumulation.	Zinc	136-140	neutrophil cytosolic factor 1	Homo sapiens	80-87
28771048-7	2017	Serum ghrelin concentration was significantly elevated in all Zn-supplemented groups, but further increased in groups nanoZnO and gamma-PGA-nanoZnO (p &lt; 0.05).	Zinc	62-64	ghrelin/obestatin prepropeptide	Gallus gallus	6-13
28771048-10	2017	In conclusion, dietary supplementation of nanoZnO and gamma-PGA-nanoZnO increased Zn content in eggshells, serum Zn concentration, ghrelin and IgG levels of aged layers when compared to regular ZnO.	Zinc	68-70	ghrelin/obestatin prepropeptide	Gallus gallus	131-138
28973460-5	2017	Here, we provide evidence for the binding of two Zn2+ atoms to Pcf11, bound to separate zinc-binding domains located on each side of the Clp1 recognition region.	Zinc	49-53	cleavage polyadenylation factor subunit CLP1	Saccharomyces cerevisiae S288C	137-141
28914300-1	2017	A Mn-incorporated Ni(OH)2/carbon fiber cloth (Mn-Ni(OH)2/CFC) fabricated via a room-temperature solution route exhibited superior electrocatalytic activities of the oxygen reduction and urea oxidation reactions, delivering 12-21% energy saving in the charging process of Mn-Ni(OH)2/CFC assembled Zn-air batteries in the presence of 0.5 M urea compared to the battery without urea.	Zinc	296-298	tubulin folding cofactor C	Homo sapiens	57-60
29209656-2	2017	Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochondrial fragmentation.	Zinc	131-135	transient receptor potential cation channel subfamily M member 2	Homo sapiens	53-58
29209656-2	2017	Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochondrial fragmentation.	Zinc	131-135	transient receptor potential cation channel subfamily M member 2	Homo sapiens	60-101
28952761-1	2017	We report muon-spin rotation and neutron-scattering experiments on nonmagnetic Zn impurity effects on the static spin-stripe order and superconductivity of the La214 cuprates.	Zinc	79-81	spindlin 1	Homo sapiens	113-117
28952761-2	2017	Remarkably, it was found that, for samples with hole doping x 1/8, the spin-stripe ordering temperature T_{so} decreases linearly with Zn doping y and disappears at y 4%, demonstrating a high sensitivity of static spin-stripe order to impurities within a CuO_{2} plane.	Zinc	135-137	spindlin 1	Homo sapiens	71-75
28952761-2	2017	Remarkably, it was found that, for samples with hole doping x 1/8, the spin-stripe ordering temperature T_{so} decreases linearly with Zn doping y and disappears at y 4%, demonstrating a high sensitivity of static spin-stripe order to impurities within a CuO_{2} plane.	Zinc	135-137	spindlin 1	Homo sapiens	214-218
28630041-7	2017	Our data also revealed that RyR2 channels are not the only SR Ca2+-permeable channels regulated by Zn2+ Elevating the cytosolic Zn2+ concentration to 1 nm increased the activity of the transmembrane protein mitsugumin 23 (MG23).	Zinc	128-132	transmembrane protein 109	Rattus norvegicus	207-220
28630041-7	2017	Our data also revealed that RyR2 channels are not the only SR Ca2+-permeable channels regulated by Zn2+ Elevating the cytosolic Zn2+ concentration to 1 nm increased the activity of the transmembrane protein mitsugumin 23 (MG23).	Zinc	128-132	transmembrane protein 109	Rattus norvegicus	222-226
28630041-8	2017	The current amplitude of the MG23 full-open state was consistent with that previously reported for RyR2 sub-conductance gating, suggesting that in heart failure in which Zn2+ levels are elevated, RyR2 channels do not gate in a sub-conductance state, but rather MG23-gating becomes more apparent.	Zinc	170-174	transmembrane protein 109	Rattus norvegicus	29-33
28630041-9	2017	We also show that in H9C2 cells exposed to ischemic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression.	Zinc	78-82	transmembrane protein 109	Rattus norvegicus	130-134
28630041-10	2017	In conclusion, these data suggest that dysregulated Zn2+ homeostasis alters the function of both RyR2 and MG23 and that both ion channels play a key role in diastolic SR Ca2+ leakage.	Zinc	52-56	transmembrane protein 109	Rattus norvegicus	106-110
28768420-7	2017	This is attributed to the larger crystallite size and higher Zn per unit area on PC as compared to glass which enabled a higher activity of GOx on ZnO/PC compared to ZnO/glass.	Zinc	61-63	hydroxyacid oxidase 1	Homo sapiens	140-143
28686686-4	2017	Although Co2+ ions have been shown to protect the kidney via hypoxia inducible factor (HIF), the effect of Zn2+ ions on the induction of HIF1alpha, HIF2alpha and HIF3alpha has not been investigated previously.	Zinc	107-111	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	137-146
28686686-4	2017	Although Co2+ ions have been shown to protect the kidney via hypoxia inducible factor (HIF), the effect of Zn2+ ions on the induction of HIF1alpha, HIF2alpha and HIF3alpha has not been investigated previously.	Zinc	107-111	endothelial PAS domain protein 1	Rattus norvegicus	148-157
28370392-2	2017	Metallothionein-3 (MT3), an isoform of the metal-binding proteins, metallothioneins, involved in maintaining intracellular zinc (Zn) homeostasis and the deregulation of zinc homeostasis, has separately been implicated in AD.	Zinc	129-131	metallothionein 3	Homo sapiens	0-17
28370392-2	2017	Metallothionein-3 (MT3), an isoform of the metal-binding proteins, metallothioneins, involved in maintaining intracellular zinc (Zn) homeostasis and the deregulation of zinc homeostasis, has separately been implicated in AD.	Zinc	129-131	metallothionein 3	Homo sapiens	19-22
28370392-3	2017	Here, we investigated the effect of ELFEMF-induced neural differentiation of hBM-MSCs on Zn-MT3 homeostatic interaction.	Zinc	89-91	metallothionein 3	Homo sapiens	92-95
28483671-10	2017	This was due to the inhibition of acrolein conjugation with His405 and 411 located at the Zn2+ binding site of MMP-9.	Zinc	90-94	matrix metallopeptidase 9	Homo sapiens	111-116
28483530-0	2017	LAMP-2 mediates oxidative stress-dependent cell death in Zn2+-treated lung epithelium cells.	Zinc	57-61	lysosomal associated membrane protein 2	Homo sapiens	0-6
28483530-5	2017	Herein, we demonstrated that Zn2+ could induce deglycosylation of lysosome-associated membrane protein 1 and 2 (LAMP-1 and LAMP-2), which primarily locate in late endosomes/lysosomes, in A549 lung epithelium cells.	Zinc	29-33	lysosomal associated membrane protein 2	Homo sapiens	123-129
28483530-6	2017	Intriguingly, LAMP-2 knockdown further aggravated Zn2+-mediated ROS production and cell death, indicating LAMP-2 (not LAMP-1) was involved in Zn2+-induced toxicity.	Zinc	50-54	lysosomal associated membrane protein 2	Homo sapiens	14-20
28273533-5	2017	In addition, P1, P2, and P3 promoted the transformation of ZnO NPs into zinc phosphate (Zn-P) precipitates via interactions with dissolved Zn2+.	Zinc	139-143	crystallin gamma F, pseudogene	Homo sapiens	13-27
28322340-3	2017	H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ34, a PARP inhibitor, and abolished by TRPM2 knockout (TRPM2-KO).	Zinc	5-9	transient receptor potential cation channel subfamily M member 2	Homo sapiens	159-164
28322340-3	2017	H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ34, a PARP inhibitor, and abolished by TRPM2 knockout (TRPM2-KO).	Zinc	5-9	transient receptor potential cation channel subfamily M member 2	Homo sapiens	175-180
28322340-4	2017	Pathological concentrations of H2O2/Zn2+ induced substantial cell death that was inhibited by PJ34 and DPQ, PARP inhibitors, 2-APB, a TRPM2 channel inhibitor, and prevented by TRPM2-KO.	Zinc	36-40	transient receptor potential cation channel subfamily M member 2	Homo sapiens	134-139
28322340-4	2017	Pathological concentrations of H2O2/Zn2+ induced substantial cell death that was inhibited by PJ34 and DPQ, PARP inhibitors, 2-APB, a TRPM2 channel inhibitor, and prevented by TRPM2-KO.	Zinc	36-40	transient receptor potential cation channel subfamily M member 2	Homo sapiens	176-181
28322340-5	2017	Further analysis indicate that Zn2+ induced ROS production, PARP-1 stimulation, increase in the [Ca2+]c and cell death, all of which were suppressed by chelerythrine, a protein kinase C inhibitor, DPI, a NADPH-dependent oxidase (NOX) inhibitor, GKT137831, a NOX1/4 inhibitor, and Phox-I2, a NOX2 inhibitor.	Zinc	31-35	cytochrome b-245 beta chain	Homo sapiens	291-295
12482872-3	2003	A specific effect of Zn(2+) on the thermal stability of rhodopsin, obtained from bovine retinas and solubilized in dodecyl maltoside detergent, in the dark is reported.	Zinc	21-23	rhodopsin	Bos taurus	56-65
28096460-10	2017	In contrast, Zn2+ elicited biphasic effects on transport, i.e. stimulation at 1 mum and inhibition at 10 mum A kinetic model that posited preferential binding of transition metal ions to the outward-facing apo state of DAT and a reciprocal interaction of dopamine and transition metals recapitulated all experimental findings.	Zinc	13-17	solute carrier family 6 member 3	Homo sapiens	219-222
28096460-11	2017	Allosteric activation of DAT via the Zn2+-binding site may be of interest to restore transport in loss-of-function mutants.	Zinc	37-41	solute carrier family 6 member 3	Homo sapiens	25-28
12482872-4	2003	The thermal stability of rhodopsin in its ground state (dark state) is clearly reduced with increasing Zn(2+) concentrations (0-50 microm Zn(2+)).	Zinc	103-109	rhodopsin	Bos taurus	25-34
12482872-4	2003	The thermal stability of rhodopsin in its ground state (dark state) is clearly reduced with increasing Zn(2+) concentrations (0-50 microm Zn(2+)).	Zinc	103-105	rhodopsin	Bos taurus	25-34
12482872-9	2003	These effects, specific for zinc, are also seen for rhodopsin in native disc membranes, and may be relevant to the suggested role of Zn(2+) in normal and pathological retinal function.	Zinc	133-135	rhodopsin	Bos taurus	52-61
28086172-5	2017	The suppression threshold of Zn (II) on AOB in short-term effect was 10mgL-1, which rose to 50mgL-1 in the long-term effect due to the self-adaption.	Zinc	29-31	LLGL scribble cell polarity complex component 1	Homo sapiens	71-76
28086172-5	2017	The suppression threshold of Zn (II) on AOB in short-term effect was 10mgL-1, which rose to 50mgL-1 in the long-term effect due to the self-adaption.	Zinc	29-31	LLGL scribble cell polarity complex component 1	Homo sapiens	94-99
12620355-8	2003	Affinity-purified phytochelatin synthase preparations required divalent heavy metal ions such as Cd(2+), Zn(2+) or Cu(2+) for detectable turnover of glutathione-S-conjugates.	Zinc	105-107	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	18-40
28204942-4	2017	In agreement with the clinical tests performed on the C203Y patient, protein modeling and molecular dynamics suggest that direct interactions with RIPK2 and Caspase3 are altered by the C203Y mutation and subsequent loss of Zn coordination in the second BIR domain of XIAP.	Zinc	223-225	receptor interacting serine/threonine kinase 2	Homo sapiens	147-152
28204942-4	2017	In agreement with the clinical tests performed on the C203Y patient, protein modeling and molecular dynamics suggest that direct interactions with RIPK2 and Caspase3 are altered by the C203Y mutation and subsequent loss of Zn coordination in the second BIR domain of XIAP.	Zinc	223-225	X-linked inhibitor of apoptosis	Homo sapiens	267-271
28232787-5	2017	The co-administration of Cu2+ and Zn2+ also significantly increased the expression of genes related to the endoplasmic reticulum"s stress response, including CHOP, GADD34, and ATF4.	Zinc	34-38	protein phosphatase 1, regulatory subunit 15A	Mus musculus	164-170
27915020-5	2017	Meanwhile, Mg2+ ions from Zn/Mg-PIII increased Mg2+ influx by upregulating the expression of MagT1 transporter in human umbilical vein endothelial cells (HUVECs), and then stimulated the transcription of VEGF and KDR via activation of hypoxia inducing factor (HIF)-1alpha, thus inducing angiogenesis.	Zinc	26-28	magnesium transporter 1	Homo sapiens	93-98
27915020-5	2017	Meanwhile, Mg2+ ions from Zn/Mg-PIII increased Mg2+ influx by upregulating the expression of MagT1 transporter in human umbilical vein endothelial cells (HUVECs), and then stimulated the transcription of VEGF and KDR via activation of hypoxia inducing factor (HIF)-1alpha, thus inducing angiogenesis.	Zinc	26-28	kinase insert domain receptor	Homo sapiens	213-216
12559473-6	2003	Serum leptin concentration was positively correlated with body weight and body fat, and negatively correlated with adipose Zn concentration.	Zinc	123-125	leptin	Mus musculus	6-12
28100752-5	2017	However, using knock-out animals (of MT-III and vesicular Zn2+ transporter, ZnT3) and channel blockers revealed substantial differences in relevant Zn2+ sources, with critical contributions of presynaptic release and its permeation through Ca2+- (and Zn2+)-permeable AMPA channels in CA3 and Zn2+ mobilization from MT-III predominating in CA1.	Zinc	148-152	solute carrier family 30 (zinc transporter), member 3	Mus musculus	76-80
12559473-10	2003	In summary, the reduced adipose Zn concentrations in HF-fed mice and the negative correlation between serum leptin and adipose Zn concentrations support an interrelationship among obesity, leptin and Zn metabolism.	Zinc	127-129	leptin	Mus musculus	108-114
28100752-5	2017	However, using knock-out animals (of MT-III and vesicular Zn2+ transporter, ZnT3) and channel blockers revealed substantial differences in relevant Zn2+ sources, with critical contributions of presynaptic release and its permeation through Ca2+- (and Zn2+)-permeable AMPA channels in CA3 and Zn2+ mobilization from MT-III predominating in CA1.	Zinc	148-152	solute carrier family 30 (zinc transporter), member 3	Mus musculus	76-80
12559473-10	2003	In summary, the reduced adipose Zn concentrations in HF-fed mice and the negative correlation between serum leptin and adipose Zn concentrations support an interrelationship among obesity, leptin and Zn metabolism.	Zinc	127-129	leptin	Mus musculus	189-195
27885880-4	2017	The clinical and experimental evidence for the common ZIP transporter/Zn down regulation in these cancers.	Zinc	70-72	death associated protein kinase 3	Homo sapiens	54-57
12559473-10	2003	In summary, the reduced adipose Zn concentrations in HF-fed mice and the negative correlation between serum leptin and adipose Zn concentrations support an interrelationship among obesity, leptin and Zn metabolism.	Zinc	127-129	leptin	Mus musculus	108-114
27834679-1	2016	The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding.	Zinc	81-85	C-C motif chemokine receptor 5	Homo sapiens	112-116
12559473-10	2003	In summary, the reduced adipose Zn concentrations in HF-fed mice and the negative correlation between serum leptin and adipose Zn concentrations support an interrelationship among obesity, leptin and Zn metabolism.	Zinc	127-129	leptin	Mus musculus	189-195
27834679-1	2016	The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding.	Zinc	81-85	C-C motif chemokine receptor 5	Homo sapiens	187-191
27834679-1	2016	The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding.	Zinc	81-85	C-C motif chemokine ligand 5	Homo sapiens	246-250
12372826-6	2002	We report here that tetramerization of the Shal (rKv4.2) T1 in solution requires the presence of Zn(2+), and the addition/removal of Zn(2+) reversibly switches the protein between a stable tetrameric or monomeric state.	Zinc	97-99	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	49-59
27694524-8	2016	In contrast, AtPCS1 mutants grown under Zn-limited conditions showed wild-type levels of Zn accumulation, suggesting the operation of distinct Zn translocation pathways.	Zinc	89-91	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	13-19
27694524-8	2016	In contrast, AtPCS1 mutants grown under Zn-limited conditions showed wild-type levels of Zn accumulation, suggesting the operation of distinct Zn translocation pathways.	Zinc	89-91	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	13-19
27694524-9	2016	Contrasting phenotypes of the tested AtPCS1 mutant alleles upon growth in Zn- or Cd-contaminated soil indicated differential activation of PC synthesis by these metals.	Zinc	74-76	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	37-43
27694524-10	2016	Experiments with truncated versions identified a part of the AtPCS1 protein required for the activation by Zn but not by Cd.	Zinc	107-109	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	61-67
12372826-6	2002	We report here that tetramerization of the Shal (rKv4.2) T1 in solution requires the presence of Zn(2+), and the addition/removal of Zn(2+) reversibly switches the protein between a stable tetrameric or monomeric state.	Zinc	133-135	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	49-59
27506361-1	2016	A novel multi-function Metal-Organic Framework composite Ag@Zn-TSA (zinc thiosalicylate, Zn(C7H4O2S), Zn-TSA) was synthesized as highly efficient immobilization matrixes of myoglobin (Mb)/glucose oxidase (GOx) for electrochemical biosensing.	Zinc	60-62	hydroxyacid oxidase 1	Homo sapiens	205-208
12642989-5	2002	Compared with the control group, the zinc-deficient group and zinc-excess (Zn2+ 120 mumol/L) group contained less osteocalcin (BGP) and 45Ca content, and lower AKP activity; whereas zinc-normal (Zn2+ 45 mumol/L and Zn2+ 70 mumol/L) groups contained more BGP and 45Ca contents, and higher AKP (alkaline phosphatase) activity.	Zinc	75-78	bone gamma-carboxyglutamate protein 2	Mus musculus	127-130
27695784-11	2016	There was a tendency for increasing Zn supplementation to decrease plasma haptoglobin within RAC-fed steers ( = 0.07), suggesting that Zn may alter the inflammatory response.	Zinc	36-38	haptoglobin	Bos taurus	74-85
12421840-7	2002	Rats fed a low Zn or low vitamin A diet had lower ZnT-1 protein and higher ZnT-4 mRNA expression and protein levels compared with controls.	Zinc	15-17	solute carrier family 30 member 1	Rattus norvegicus	50-55
27232456-0	2016	Molecular dynamics study of human carbonic anhydrase II in complex with Zn(2+) and acetazolamide on the basis of all-atom force field simulations.	Zinc	72-78	carbonic anhydrase 2	Homo sapiens	34-55
12359264-2	2002	In this study we have examined the localization of pro-caspase-3 and Zn(2+), a cellular regulator of pro-caspase-3, in primary sheep and human AEC.	Zinc	69-71	caspase-3	Ovis aries	105-114
12359264-4	2002	Depletion of intracellular Zn(2+) in sheep AEC, using the membrane permeant Zn(2+) chelator TPEN, increased lipid peroxidation in the apical cell membranes (as assessed by immunofluorescence with anti-hydroxynonenal) as well as increasing activated pro-caspase-3 and apoptosis.	Zinc	27-29	caspase-3	Ovis aries	253-262
26399199-7	2016	Expression of interleukin-6 was higher (P &lt; 0.01) in in ovo I supplemented chicks (2.5-fold) but lower in the Zn and Se groups than in the un-injected control group.	Zinc	113-115	interleukin 6	Gallus gallus	14-27
12359264-4	2002	Depletion of intracellular Zn(2+) in sheep AEC, using the membrane permeant Zn(2+) chelator TPEN, increased lipid peroxidation in the apical cell membranes (as assessed by immunofluorescence with anti-hydroxynonenal) as well as increasing activated pro-caspase-3 and apoptosis.	Zinc	27-31	caspase-3	Ovis aries	253-262
12359264-7	2002	These findings suggest that cytoplasmic pro-caspase-3 is positioned near the lumenal surface of AEC where it is under the influence of Zn(2+) and other anti-oxidants.	Zinc	135-137	caspase-3	Ovis aries	44-53
12368662-6	2002	The Zn translocation observed in hippocampus CA1, CA2, and Hilus 72 hours after 20 minutes of TGI was significantly reduced by mild hypothermia.	Zinc	4-6	carbonic anhydrase 1	Mus musculus	45-48
12217694-8	2002	Crystal soaking experiments revealed a binding site for Zn(2+) and Hg(2+), two known PSA inhibitors.	Zinc	56-58	kallikrein related peptidase 3	Homo sapiens	85-88
12045193-3	2002	This high affinity for Zn(2+) is attributed to the unusual high Cys content of S100A3.	Zinc	23-25	S100 calcium binding protein A3	Homo sapiens	79-85
12045193-7	2002	The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion.	Zinc	70-72	S100 calcium binding protein A3	Homo sapiens	25-31
12045193-7	2002	The crystal structure of S100A3 allows the prediction of one putative Zn(2+) binding site in the C terminus of each subunit of S100A3 involving Cys and His residues in the coordination of the metal ion.	Zinc	70-72	S100 calcium binding protein A3	Homo sapiens	127-133
12226493-10	2002	ECA1 provided increased tolerance of yeast mutant to toxic levels of Mn(2+) (1 mM) and Zn(2+)(3 mM), consistent with removal of these ions from the cytoplasm.	Zinc	87-93	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	0-4
16290766-0	2002	Dithiol-mediated immobilization of CdS nanoparticles from reverse micellar system onto Zn-doped silica particles and their high photocatalytic activity.	Zinc	87-89	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
16290766-1	2002	Cds nanoparticles, prepared in a reverse micellar system, were immobilized directly onto alkanedithiol-modified Zn-doped silica particles, which were themselves prepared via hydrolysis of tetraethylorthosilicate in the presence of Zn(NO(3))(2) followed by contact with dithiol molecules.	Zinc	112-114	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
16290766-4	2002	This is effected by electron transfer from the photoexcited ZnS (dithiol-bonded Zn on SiO(2)) to CdS nanoparticles.	Zinc	60-62	CDP-diacylglycerol synthase 1	Homo sapiens	97-100
12079460-6	2002	The luminescence of Ru-2 and Ru-4 is quenched in the presence of Zn(2+) because of a conformationally induced reduction in electronic communication between the two phen halves of the ligand.	Zinc	65-67	doublecortin domain containing 2	Homo sapiens	20-24
12079460-7	2002	The addition of Zn(2+) has only a slight effect on the luminescence of Ru-1 because of steric hindrance toward complexation.	Zinc	16-18	Scm like with four mbt domains 1	Homo sapiens	71-75
12044548-2	2002	Zn(2+) also completely inhibited the activation of caspase-3-, caspase-6-, and caspase-9-like proteases in ricin-treated cells, while no significant effect of Zn(2+) on these protease activities was observed when added directly to the lysate of ricin-treated cells, suggesting that Zn(2+) blocks the process of the activation of these caspases rather than the direct inhibition of the already activated enzymes.	Zinc	0-2	caspase 6	Homo sapiens	63-72
12044548-2	2002	Zn(2+) also completely inhibited the activation of caspase-3-, caspase-6-, and caspase-9-like proteases in ricin-treated cells, while no significant effect of Zn(2+) on these protease activities was observed when added directly to the lysate of ricin-treated cells, suggesting that Zn(2+) blocks the process of the activation of these caspases rather than the direct inhibition of the already activated enzymes.	Zinc	0-2	caspase 6	Homo sapiens	335-343
11943669-9	2002	In summary, exposure to As, Zn, and V initiated EGFR signaling and Ras-dependent activation of MEK1/2 and ERK1/2, but only V induced Ras-dependent NF-kappaB nuclear translocation.	Zinc	28-30	mitogen-activated protein kinase kinase 1	Homo sapiens	95-101
11805091-6	2002	The dose-response curve for Zn(2+) inhibition was identical for AC1, AC5, and AC6 as well as for the C441R mutant of AC5 whose defect appears to be in one of the catalytic metal binding sites.	Zinc	28-30	adenylate cyclase 5	Mus musculus	69-72
11805091-6	2002	The dose-response curve for Zn(2+) inhibition was identical for AC1, AC5, and AC6 as well as for the C441R mutant of AC5 whose defect appears to be in one of the catalytic metal binding sites.	Zinc	28-30	adenylate cyclase 5	Mus musculus	117-120
12060262-5	2002	Roles of Mn2+ and Zn2+ in protection of plant cells from salt stress, as an effective superoxide scavenger and an effective inhibitor of plasma membrane-bound NADPH oxidase, respectively, are discussed.	Zinc	18-22	respiratory burst oxidase homolog protein A-like	Nicotiana tabacum	159-172
11904232-10	2002	Collectively, the present results suggest that cellular mechanisms of SH group modification and intracellular levels of Zn(2+) may play an important role in regulation of placental 11 beta-HSD2 activity.	Zinc	120-126	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	181-193
11814329-3	2002	MTF1 binding to MRE motifs is regulated by changes in intracellular zinc (Zn(2+)) concentration.	Zinc	74-80	metal response element binding transcription factor 1	Mus musculus	0-4
11814329-6	2002	Electrophoretic mobility shift assays demonstrated that MTF1 retrovirally transduced dko7 cells (MTF1dko7) possess levels of inducible MTF1-MRE binding activity similar to that seen in mouse hepatoma Hepa-1 cells, and MTF1 binding could be modulated over a 20-fold range by varying the concentration of Zn(2+) present in the culture medium.	Zinc	303-305	metal response element binding transcription factor 1	Mus musculus	56-60
11814329-6	2002	Electrophoretic mobility shift assays demonstrated that MTF1 retrovirally transduced dko7 cells (MTF1dko7) possess levels of inducible MTF1-MRE binding activity similar to that seen in mouse hepatoma Hepa-1 cells, and MTF1 binding could be modulated over a 20-fold range by varying the concentration of Zn(2+) present in the culture medium.	Zinc	303-305	metal response element binding transcription factor 1	Mus musculus	97-105
11814329-6	2002	Electrophoretic mobility shift assays demonstrated that MTF1 retrovirally transduced dko7 cells (MTF1dko7) possess levels of inducible MTF1-MRE binding activity similar to that seen in mouse hepatoma Hepa-1 cells, and MTF1 binding could be modulated over a 20-fold range by varying the concentration of Zn(2+) present in the culture medium.	Zinc	303-305	metal response element binding transcription factor 1	Mus musculus	97-101
11814329-6	2002	Electrophoretic mobility shift assays demonstrated that MTF1 retrovirally transduced dko7 cells (MTF1dko7) possess levels of inducible MTF1-MRE binding activity similar to that seen in mouse hepatoma Hepa-1 cells, and MTF1 binding could be modulated over a 20-fold range by varying the concentration of Zn(2+) present in the culture medium.	Zinc	303-305	metal response element binding transcription factor 1	Mus musculus	97-101
11814329-8	2002	Interestingly, MTF1dko7 cells showed resistance to Zn(2+) toxicity, but negligible resistance to Cd(2+).	Zinc	51-57	metal response element binding transcription factor 1	Mus musculus	15-19
11814329-9	2002	Concomitantly, MT1 protein levels in MTF1dko7 cells were inducible to the same degree as that in Hepa-1 cells when treated with Zn(2+), but not with Cd(2+).	Zinc	128-130	metal response element binding transcription factor 1	Mus musculus	37-41
11814329-10	2002	Together, our studies suggest that MTF1-mediated regulation of gene expression is sufficient to protect cells against Zn(2+) toxicity and may be necessary but not sufficient to protect cells against Cd(2+) toxicity.	Zinc	118-124	metal response element binding transcription factor 1	Mus musculus	35-39
11739784-8	2001	Surprisingly, with Ubc4 as the E2 enzyme, Zn(2+) ions alone are sufficient to catalyze the ubiquitination of cyclin B1.	Zinc	42-48	cyclin B1	Homo sapiens	109-118
11457851-5	2001	This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e. ASIC2a, ASIC1a+2a, ASIC2a+3), but not of homomeric ASIC1a and ASIC3.	Zinc	22-24	acid sensing ion channel subunit 3	Homo sapiens	185-190
11356846-13	2001	Biochemical characterization showed that aPHC had a pH optimum of 9.5, was activated by Ca(2+), but was inhibited by Zn(2+) and sphingosine.	Zinc	117-123	alkaline ceramidase 3	Homo sapiens	41-45
25682263-3	2016	Matrix metalloproteinase-9 (MMP-9), a member of the family of Zn(+2)-containing endoproteases, known to be expressed and secreted by astrocytes, is capable of degrading Abeta.	Zinc	62-68	matrix metallopeptidase 9	Homo sapiens	0-26
26940742-0	2016	Pyrithione Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3.	Zinc	11-13	egl-9 family hypoxia inducible factor 3	Homo sapiens	79-83
26771939-5	2016	Results showed daily average PM1 concentration is 102.46 +- 35.9 mug/m(3) and metal concentration followed the trend: Ca &gt; Fe &gt; Mg &gt; Zn &gt; Pb &gt; Cu &gt; Cr &gt; Ni &gt; Se &gt; Cd &gt; V &gt; As.	Zinc	142-144	transmembrane protein 11	Homo sapiens	29-32
26783088-4	2016	We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions and that excess Zn(2+) leads to inhibition of enzyme activity through binding to additional sites.	Zinc	62-64	sphingomyelin phosphodiesterase acid like 3A	Homo sapiens	35-42
26783088-4	2016	We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions and that excess Zn(2+) leads to inhibition of enzyme activity through binding to additional sites.	Zinc	90-92	sphingomyelin phosphodiesterase acid like 3A	Homo sapiens	35-42
26930473-3	2016	It is orthologous to AtZIP4 from Arabidopsis thaliana, an important actor in Zn homeostasis.	Zinc	77-79	zinc transporter	Arabidopsis thaliana	21-27
26930473-8	2016	In A. thaliana, the AtZIP4 and NcZNT1 promoters were mainly active in cortex, endodermis and pericycle cells under Zn deficient conditions.	Zinc	115-117	zinc transporter	Arabidopsis thaliana	20-26
26977182-2	2016	The optimal conditions for this reaction were found to be PdCl2(PPh3)2, ZnCl2, Et3N and Zn in THF.	Zinc	72-74	phosducin like 2	Homo sapiens	58-63
26780729-0	2016	Stress hormone potentiates Zn(2+)-induced neurotoxicity via TRPM7 channel in dopaminergic neuron.	Zinc	27-33	transient receptor potential cation channel subfamily M member 7	Homo sapiens	60-65
26739447-2	2016	External stimulation of breast cancer cells has been proposed to induce phosphorylation of ZIP7 by CK2alpha, resulting in ZIP7-mediated Zn(2+) release from the ER into the cytosol.	Zinc	136-138	casein kinase 2 alpha 2	Homo sapiens	99-107
26658105-5	2016	Using caspase-6 and -9 exosite analysis, we identified and mutated predicted Zn-ligands in caspase-3 (H108A, C148S and E272A) and overexpressed into DKO MEFs.	Zinc	77-79	caspase 3	Mus musculus	91-100
26658105-7	2016	Co-immunoprecipitation analysis revealed stronger XIAP-caspase-3 interaction suggesting a novel mechanism of impulsive apoptosis resistance by disrupting predicted Zn-ligands in caspase-3.	Zinc	164-166	caspase 3	Mus musculus	55-64
26658105-7	2016	Co-immunoprecipitation analysis revealed stronger XIAP-caspase-3 interaction suggesting a novel mechanism of impulsive apoptosis resistance by disrupting predicted Zn-ligands in caspase-3.	Zinc	164-166	caspase 3	Mus musculus	178-187
26696154-1	2016	We report transparent RO-SnO-P2O5 (R=Zn, Ba, Sr) glasses with low photoelastic constant less than ~1  B (1x10(-12)  Pa(-1)) and high refractive index more than ~1.65.	Zinc	37-39	strawberry notch homolog 2	Homo sapiens	25-28
26647834-4	2015	SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles.	Zinc	89-91	solute carrier family 30 (zinc transporter), member 3	Mus musculus	0-7
26647834-4	2015	SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles.	Zinc	89-91	solute carrier family 30 (zinc transporter), member 3	Mus musculus	20-38
26647834-4	2015	SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles.	Zinc	89-91	solute carrier family 30 (zinc transporter), member 3	Mus musculus	40-44
26338723-4	2015	By evaluating these macrocyclic polyamines and their complexes with Mn(2+), Cu(2+), Fe(3+), and Zn(2+), we have discovered novel CXCR4-binding compounds.	Zinc	96-98	C-X-C motif chemokine receptor 4	Homo sapiens	129-134
26346802-5	2015	The ability of NTAdeCage to mediate the uptake of (65) Zn(2+) by Xenopus laevis oocytes expressing hZIP4 demonstrates the viability of this photocaging strategy to execute biological assays.	Zinc	55-57	solute carrier family 39 member 4	Homo sapiens	99-104
32264585-2	2015	Here we use cysteine enantiomer-modified SeNPs (abbreviated as d/lSeNPs) to demonstrate that surface chirality strongly influences the formation of Abeta aggregates in the presence of metal ions, such as Zn2+ or Cu2+.	Zinc	204-208	amyloid beta precursor protein	Rattus norvegicus	148-153
26174742-9	2015	Interestingly, we found that Zn(2+) stimulated the phosphorylation of eIF2alpha and promoted the nuclear accumulation of activating transcription factor 4 (ATF4).	Zinc	29-35	eukaryotic translation initiation factor 2A	Rattus norvegicus	70-79
26174742-10	2015	Treatment with salubrinal, an eIF2alpha dephosphorylation inhibitor, enhanced Zn(2+)-induced ATF4 accumulation and IL-23 p19 mRNA expression.	Zinc	78-84	eukaryotic translation initiation factor 2A	Rattus norvegicus	30-39
11444825-1	2001	We developed a cell system where expression of thymidylate synthase (TS), an enzyme essential for DNA synthesis, can be modulated by a Zn(2+)-inducible promoter in MCF-7 cells.	Zinc	135-137	thymidylate synthetase	Homo sapiens	47-67
26174742-12	2015	Taken together, these findings suggest that Zn(2+) up-regulates expression of the IL-23 p19 gene via the eIF2alpha/ATF4 axis in HAPI cells.	Zinc	44-50	eukaryotic translation initiation factor 2A	Rattus norvegicus	105-114
25808614-2	2015	Recently, we demonstrated that tumor necrosis factor-alpha (TNFalpha), a cytokine released during early involution, redistributes the zinc (Zn) transporter ZnT2 to accumulate Zn in lysosomes and activate LCD and involution.	Zinc	140-142	solute carrier family 30 member 2	Homo sapiens	156-160
11444825-1	2001	We developed a cell system where expression of thymidylate synthase (TS), an enzyme essential for DNA synthesis, can be modulated by a Zn(2+)-inducible promoter in MCF-7 cells.	Zinc	135-137	thymidylate synthetase	Homo sapiens	69-71
25986320-9	2015	The relations obtained for Ca (increased level in CA3, DG, and its internal area) and Zn (decreased areal density in CA3 and DG) were analogous to those that we previously observed for rats in the acute phase of pilocarpine-induced seizures.	Zinc	86-88	carbonic anhydrase 3	Rattus norvegicus	117-120
25580958-4	2015	In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH).	Zinc	44-46	somatotropin	Ovis aries	153-167
11301334-4	2001	First, we examined (65)Zn uptake activity in K562 erythroleukemia cells overexpressing hZIP1.	Zinc	23-25	solute carrier family 39 member 1	Homo sapiens	87-92
11301334-9	2001	Furthermore, hZIP1-dependent (65)Zn uptake was biochemically indistinguishable from the endogenous activity.	Zinc	33-35	solute carrier family 39 member 1	Homo sapiens	13-18
25580958-4	2015	In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH).	Zinc	44-46	somatotropin	Ovis aries	169-171
11301334-10	2001	Finally, inhibition of endogenous hZIP1 expression with antisense oligonucleotides caused a marked decrease in endogenous (65)Zn uptake activity.	Zinc	126-128	solute carrier family 39 member 1	Homo sapiens	34-39
11430801-3	2001	Here we report a 49% decrease in brain Abeta deposition (-375 microg/g wet weight, p = 0.0001) in a blinded study of APP2576 transgenic mice treated orally for 9 weeks with clioquinol, an antibiotic and bioavailable Cu/Zn chelator.	Zinc	219-221	amyloid beta (A4) precursor protein	Mus musculus	39-44
26040283-12	2015	The negative charge of the surface coating of PVP binds to Zn(2+) from the active center of MMPs by chelate binding and results in MMP inhibition.	Zinc	59-65	matrix metallopeptidase 8	Mus musculus	92-96
11430801-6	2001	These results support targeting the interactions of Cu and Zn with Abeta as a novel therapy for the prevention and treatment of AD.	Zinc	59-61	amyloid beta (A4) precursor protein	Mus musculus	67-72
11327731-6	2001	The SHD1 and SHD2 of Slp3-a and Slp4 are separated by a putative Zn(2+)-binding sequence, whereas Slp1 and Slp2 lack such Zn(2+)-binding sequences and their SHD1 and SHD2 are linked together.	Zinc	65-71	synaptotagmin-like 3	Mus musculus	21-27
11423905-1	2001	It has previously been documented that Zn2+ inhibits TrkA-mediated effects of NGF.	Zinc	39-43	neurotrophic receptor tyrosine kinase 1	Gallus gallus	53-57
26051901-2	2015	Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.	Zinc	95-97	egl-9 family hypoxia inducible factor 3	Homo sapiens	87-91
10923625-16	2000	Morphological evaluations revealed that Cd or Zn preincubation led to relative preservation of MAP2 staining and GFAP.	Zinc	46-48	microtubule associated protein 2	Homo sapiens	95-99
25892083-5	2015	Unlike the bacterial protein, the HSP33 from C. reinhardtii had lost the first cysteine residue of its center, diminishing Zn-binding activity under all conditions.	Zinc	123-125	uncharacterized protein	Chlamydomonas reinhardtii	34-39
25511253-6	2015	The reactivity of the Zn-loaded forms of MT1 and MT4 is intermediate between those of MT3 and MT2.	Zinc	22-24	metallothionein 4	Homo sapiens	49-52
25511253-6	2015	The reactivity of the Zn-loaded forms of MT1 and MT4 is intermediate between those of MT3 and MT2.	Zinc	22-24	metallothionein 3	Homo sapiens	86-89
25531417-0	2015	Effective removal of zinc (II) from aqueous solutions by tricalcium aluminate (C3A).	Zinc	21-30	complement C3	Homo sapiens	79-82
25531417-5	2015	The adsorption capacity of C3A for Zn(2+) was computed to be up to 13.73 mmol g(-1), and the highest zinc removal capacity was obtained when the initial pH of Zn(NO3)2 solution was between 6.0 and 7.0, with temperature around 308 K. The XRD analysis showed that the resultant products were ZnAl-LDHs.	Zinc	35-37	complement C3	Homo sapiens	27-30
25562606-0	2015	TRPM2-mediated intracellular Zn2+ release triggers pancreatic beta-cell death.	Zinc	29-33	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
25562606-3	2015	Recent studies however revealed that TRPM2 channels can also conduct Zn2+, but the physiological relevance of this property is enigmatic.	Zinc	69-73	transient receptor potential cation channel subfamily M member 2	Homo sapiens	37-42
25562606-4	2015	Given that Zn2+ is cytotoxic, we asked whether TRPM2 channels can permeate sufficient Zn2+ to affect cell viability.	Zinc	86-90	transient receptor potential cation channel subfamily M member 2	Homo sapiens	47-52
25562606-6	2015	H2O2 activation of TRPM2 channels increases the cytosolic levels of both Ca2+ and Zn2+ and causes apoptotic cell death.	Zinc	82-86	transient receptor potential cation channel subfamily M member 2	Homo sapiens	19-24
25562606-9	2015	Lysosomes express TRPM2 channels, providing a potential route for Zn2+ release.	Zinc	66-70	transient receptor potential cation channel subfamily M member 2	Homo sapiens	18-23
25562606-12	2015	These results argue that TRPM2-mediated, Ca2+-potentiated Zn2+ release underlies ROS-induced beta-cell death and Zn2+, rather than Ca2+, plays a primary role in apoptosis.	Zinc	58-62	transient receptor potential cation channel subfamily M member 2	Homo sapiens	25-30
25562606-12	2015	These results argue that TRPM2-mediated, Ca2+-potentiated Zn2+ release underlies ROS-induced beta-cell death and Zn2+, rather than Ca2+, plays a primary role in apoptosis.	Zinc	113-117	transient receptor potential cation channel subfamily M member 2	Homo sapiens	25-30
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-132	MX dynamin like GTPase 2	Homo sapiens	98-101
25440581-1	2015	The complexes derived the reactions of 1-(2-hydroxybenzoyl)-4-phenylthiosemicarbazide (L(1)) with MX2 (M = Co(II), Cu(II) and Zn(II) ions; X = Cl(-) in case of Co(II) and Cu(II) ions, Cl(-) and Ac(-) in case of Zn(II)) in EtOH, were synthesized and characterized.	Zinc	126-128	MX dynamin like GTPase 2	Homo sapiens	98-101
25381639-7	2015	However, Zn supplementation to Al treated rats resulted in a reduction in the protein expressions of cytochrome c, Bax, Apaf-1, caspase 9, caspase 3 (p17), caspase 8, caspase 6 and caspase 7 whereas it elevated the Bcl-2 in both the regions.	Zinc	9-11	caspase 8	Rattus norvegicus	156-165
25201908-7	2015	The CPCs with ZnBG showed increased ALP activity, enhanced formation of mineralized nodules, and upregulated mRNA expression of DMP-1, DSPP, Runx2, and osterix in a time- and dose-dependent manner, relative to CPCs without Zn.	Zinc	14-16	ATHS	Homo sapiens	36-39
25422498-0	2015	Two metal-tolerance proteins, MTP1 and MTP4, are involved in Zn homeostasis and Cd sequestration in cucumber cells.	Zinc	61-63	metal tolerance protein B	Cucumis sativus	39-43
25422498-5	2015	When expressed in yeast, CsMTP1 and CsMTP4 were able to complement the hypersensitivity of mutant strains to Zn and Cd through the increased sequestration of metals within vacuoles using the transmembrane electrochemical gradient.	Zinc	109-111	metal tolerance protein B	Cucumis sativus	36-42
25422498-7	2015	Changes in the abundance of CsMTP1 and CsMTP4 transcripts and proteins in response to elevated Zn and Cd, or to Zn deprivation, suggested metal-induced transcriptional, translational, and post-translational modifications of protein activities.	Zinc	95-97	metal tolerance protein B	Cucumis sativus	39-45
25422498-7	2015	Changes in the abundance of CsMTP1 and CsMTP4 transcripts and proteins in response to elevated Zn and Cd, or to Zn deprivation, suggested metal-induced transcriptional, translational, and post-translational modifications of protein activities.	Zinc	112-114	metal tolerance protein B	Cucumis sativus	39-45
25422498-8	2015	The differences in the organ expression and affinity of both proteins to Zn and Cd suggested that CsMTP1 and CsMTP4 may not be functionally redundant in cucumber cells.	Zinc	73-75	metal tolerance protein B	Cucumis sativus	109-115
25579424-0	2015	N-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+).	Zinc	64-66	cadherin 2	Homo sapiens	0-10
25465483-8	2015	In contrast, for Zn substituted STA-2, both X-ray diffraction and NMR spectroscopy show less preference for substitution onto Al1 or Al2, with both appearing to be present, although that into Al1 appears slightly more favoured.	Zinc	17-19	ephrin A5	Homo sapiens	126-129
25036455-1	2015	Five metal complexes derived the reactions of 4-allyl-1-(2-hydroxybenzoyl) thiosemicarbazide (L(1)) with MX2 (M=Co(2+), Cu(2+) and Zn(2+) ions; X=Cl(-) in case of Co(2+) and Cu(2+) ions and Cl(-) and Ac(-) in case of Zn(2+) ion) in EtOH were synthesized and characterized.	Zinc	131-133	MX dynamin like GTPase 2	Homo sapiens	105-108
25036455-1	2015	Five metal complexes derived the reactions of 4-allyl-1-(2-hydroxybenzoyl) thiosemicarbazide (L(1)) with MX2 (M=Co(2+), Cu(2+) and Zn(2+) ions; X=Cl(-) in case of Co(2+) and Cu(2+) ions and Cl(-) and Ac(-) in case of Zn(2+) ion) in EtOH were synthesized and characterized.	Zinc	217-219	MX dynamin like GTPase 2	Homo sapiens	105-108
25169754-2	2015	Inhibition of TRPM7 activity and TRPM7-mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of stroke.	Zinc	62-64	transient receptor potential cation channel subfamily M member 7	Homo sapiens	33-38
25169754-5	2015	Fluorescent Zn(2+) imaging technique was used to study the effect of lidocaine on TRPM7-mediated intracellular Zn(2+) accumulation.	Zinc	12-18	transient receptor potential cation channel subfamily M member 7	Homo sapiens	82-87
25169754-5	2015	Fluorescent Zn(2+) imaging technique was used to study the effect of lidocaine on TRPM7-mediated intracellular Zn(2+) accumulation.	Zinc	111-117	transient receptor potential cation channel subfamily M member 7	Homo sapiens	82-87
26521879-5	2015	Our studies on MBLs, and especially on IMP-1, focus on understanding the role of Zn(II) ion(s) in the hydrolysis of beta-lactam antibiotics and on the detailed structure of the IMP-1 active site in order to develop efficient inhibitors.	Zinc	81-87	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	39-44
24720651-7	2014	After calving, Sahiwal cows supplemented with Zn + Vit E had higher plasma TIG, IgG and IL-2 in comparison with cows of control and Zn + Vit E-fed groups.	Zinc	46-48	interleukin 2	Bos taurus	88-92
25157844-9	2014	More importantly, the AtBFN2/A5T structure reveals a novel and conserved secondary binding site, which seems to be important for plant Zn(2+)-dependent endonucleases.	Zinc	135-137	endonuclease 2	Arabidopsis thaliana	22-28
24852612-10	2014	Amongst heavy metals Zn and Pb were found at the highest concentrations in both PM2.5 and PM1.	Zinc	21-23	transmembrane protein 11	Homo sapiens	90-93
24787898-0	2014	Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration.	Zinc	19-23	carbonic anhydrase 2	Homo sapiens	45-48
24787898-2	2014	We recently examined changes in intracellular Zn(2+) and Ca(2+) in CA1 pyramidal neurons subjected to oxygen glucose deprivation (OGD), and found that Zn(2+) rises precede and contribute to the onset of terminal Ca(2+) rises ("Ca(2+) deregulation"), which are causatively linked to a lethal loss of membrane integrity.	Zinc	46-48	carbonic anhydrase 1	Homo sapiens	67-70
24832541-6	2014	Importantly, high Zn favours production of the longer ZIF2.2 transcript, which compared to ZIF2.1 confers greater Zn tolerance to transgenic plants by promoting higher root Zn immobilization.	Zinc	114-116	Major facilitator superfamily protein	Arabidopsis thaliana	54-58
24832541-9	2014	Collectively, our findings indicate that alternative splicing controls the levels of a Zn-responsive mRNA variant of the ZIF2 transporter to enhance plant tolerance to the metal ion.	Zinc	87-89	Major facilitator superfamily protein	Arabidopsis thaliana	121-125
24970226-7	2014	XAS on HPRG isolated from the AMPD complex showed that zinc is bound to the protein in a dinuclear cluster where each Zn2+ ion is coordinated by three histidine and one heavier ligand, likely sulfur from cysteine.	Zinc	118-122	histidine rich glycoprotein	Homo sapiens	7-11
24591003-5	2014	Further analysis revealed that Zn supplementation facilitated cell survival through increasing nuclear translocation of NF-E2-related factor 2 (Nrf2), leading to increased regulation of levels of two antioxidant enzymes, hemeoxygenase-1 and glutamate cysteine ligase, which provided an adaptive survival response against the HG-induced oxidative cytotoxicity.	Zinc	31-33	heme oxygenase 1	Rattus norvegicus	221-266
24635441-2	2014	Two of these ligands display a monodentate mode of coordination to the active site Zn(2+) ion in hCAII that is not recapitulated in model complexes of the enzyme active site.	Zinc	83-89	carbonic anhydrase 2	Homo sapiens	97-102
24673930-9	2014	Furthermore, pigs receiving high Zn diet showed a down-regulation of interferon (IFN)-alpha, oligoadenylate synthetase (OAS), Zn transporter SLC39A4 (ZIP4), but up-regulation of metallothionein-1 (MT1), as well as the Zn transporters SLC30A1 (ZnT1) and SLC30A5 (ZnT5).	Zinc	33-35	interferon-alpha-14	Sus scrofa	69-91
24658588-8	2014	Hepatic TNF-alpha, IL-1beta, and IL-6 gene expression were higher in the Zn+ control group (p &lt; 0.05), and hepatic Delta6 desaturase was significantly higher in the Zn+ group (p &lt; 0.001).	Zinc	73-75	interleukin 6	Gallus gallus	33-37
24658588-8	2014	Hepatic TNF-alpha, IL-1beta, and IL-6 gene expression were higher in the Zn+ control group (p &lt; 0.05), and hepatic Delta6 desaturase was significantly higher in the Zn+ group (p &lt; 0.001).	Zinc	73-75	fatty acid desaturase 2	Gallus gallus	124-135
24658588-8	2014	Hepatic TNF-alpha, IL-1beta, and IL-6 gene expression were higher in the Zn+ control group (p &lt; 0.05), and hepatic Delta6 desaturase was significantly higher in the Zn+ group (p &lt; 0.001).	Zinc	168-170	fatty acid desaturase 2	Gallus gallus	124-135
24478111-6	2014	Cu(II) and Zn(II) coordination to terpy(GCN4bd)2 promotes binding to AP1 DNA, and to a lesser extent half-CRE DNA.	Zinc	11-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-72
24529376-4	2014	ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.	Zinc	14-18	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	112-119
25049948-13	2014	There were linear increases (p&lt;0.05) in the total tract digestibility of Ca, total P, Na, K, Mg, and Zn as well as in the retention of Mg and Zn with increased phytase dose.	Zinc	145-147	phytase	Zea mays	163-170
24311739-7	2014	Further studies using cultured cells and a two-chamber Transwell device showed that Pb treatment significantly reduced the cellular Zn concentration and led to an increased transport of Zn across the BCB, the effect that may be due to the increased ZnT2 by Pb exposure.	Zinc	186-188	solute carrier family 30 member 2	Rattus norvegicus	249-253
23617838-7	2014	SV2C staining was located in the inner molecular layer of the dentate gyrus and colocalized with dynorphin, ZnT3 and VGLUT1, suggesting selective expression in presynaptic glutamatergic Zn(2+) -rich terminals of abnormal sprouting fibres.	Zinc	108-110	synaptic vesicle glycoprotein 2C	Homo sapiens	0-4
24380370-3	2014	Analyses in BEAS-2B immortalized bronchial epithelial cells showed rapid PTP-mediated dephosphorylation of the substrate (2.2 pmol min(-1) mg(-1)) that was blocked by pretreatment of the cells with the PTP inhibitors pervanadate, Zn(2+), and 1,2-naphthoquinone (76%, 69%, and 100% inhibition relative to PTP activity in untreated controls, respectively).	Zinc	230-232	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	73-76
24380370-5	2014	In primary hAECs, dephosphorylation of the substrate occurred at a rate of 2.2 pmol min(-1) mg(-1) and was also effectively inhibited by preincubation of the cells with the inhibitors pervanadate, Zn(2+), and 1,2-naphthoquinone (91%, 88%, and 87% median PTP inhibition, respectively).	Zinc	197-199	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	254-257
24745988-1	2014	The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are involved in the essential maintenance of cellular zinc (Zn2+) and copper (Cu2+) homeostasis, respectively.	Zinc	143-147	death associated protein kinase 3	Homo sapiens	57-60
24396300-5	2013	Partial density states calculation further suggests that the appearance of the half-metallic ferromagnetism in ZnO nanorod with V(Zn) originates from the hybridization of the O2p states with Zn 3d states.	Zinc	111-113	immunoglobulin kappa variable 1D-39	Homo sapiens	175-178
24396300-5	2013	Partial density states calculation further suggests that the appearance of the half-metallic ferromagnetism in ZnO nanorod with V(Zn) originates from the hybridization of the O2p states with Zn 3d states.	Zinc	130-132	immunoglobulin kappa variable 1D-39	Homo sapiens	175-178
23947440-0	2013	Effects of Zn2+ binding on the structural and dynamic properties of amyloid beta peptide associated with Alzheimer"s disease: Asp1 or Glu11?	Zinc	11-15	beta-secretase 2	Homo sapiens	126-130
23947440-4	2013	In this work, two 3N1O Zn(2+) binding modes were constructed with three histidines (His(6), His(13), and His(14)), and Asp(1)/Glu(11) of Abeta40 coordinated to Zn(2+).	Zinc	23-25	beta-secretase 2	Homo sapiens	119-125
24077247-2	2013	Matrix metalloproteinases (MMPs) are Zn-dependent enzymes that regulate ECM turnover in concert with their inhibitors, tissue inhibitors of metalloproteinases (TIMPs).	Zinc	37-39	matrix metallopeptidase 2	Mus musculus	27-31
23971073-1	2013	A new turn-on fluorescent chemosensor, DPPL1, was rationally designed and synthesized based on diketopyrrolopyrrole (DPP), which presented high sensitivity and selectivity for Zn(2+).	Zinc	176-178	phospholipid phosphatase 5	Homo sapiens	39-44
23971073-2	2013	Specifically, DPPL1 presented a large emission enhancement and a 70 nm blue-shift upon Zn(2+) binding.	Zinc	87-93	phospholipid phosphatase 5	Homo sapiens	14-19
24070197-3	2013	Zn(2+) ion binding may influence BDNF activity.	Zinc	0-6	brain derived neurotrophic factor	Homo sapiens	33-37
24070197-8	2013	Zn(2+) addition to the cell culture medium induces an increase in the proliferative activity of the BDNF(1-12) peptide and of the whole protein on the SHSY5Y neuroblastoma cell line.	Zinc	0-2	brain derived neurotrophic factor	Homo sapiens	100-104
24070197-9	2013	The effect of Zn(2+) is opposite to that previously observed for Cu(2+) addition, which determines a decrease in the proliferative activity for both peptide and protein, suggesting that these metals might discriminate and modulate differently the activity of BDNF.	Zinc	14-16	brain derived neurotrophic factor	Homo sapiens	259-263
23772702-6	2013	Accordingly, we used Blue native PAGE and showed that the profound inhibition caused by propofol in the presence of Zn2+ is coupled with the reversible clustering of AQP4 tetramers.	Zinc	116-120	aquaporin 4	Homo sapiens	166-170
23772702-8	2013	Overall, we discovered that propofol specifically and reversibly inhibits AQP4 through the interaction between Zn2+ and Cys253.	Zinc	111-115	aquaporin 4	Homo sapiens	74-78
23936097-7	2013	In the absence of Zn(+2), the NS3 protease adopts a partially-folded inactive conformation.	Zinc	18-20	KRAS proto-oncogene, GTPase	Homo sapiens	30-33
23936053-8	2013	CrCaf1 degraded poly(A) in a distributive mode with the optimal reacting conditions at pH 7 and 35 C. CrCaf1 had similar activity when coordinated with Mg(2+) and Mn(2+), while the enzyme bound to Ca(2+) or Zn(2+) was almost inactivated.	Zinc	207-209	uncharacterized protein	Chlamydomonas reinhardtii	0-6
23936053-8	2013	CrCaf1 degraded poly(A) in a distributive mode with the optimal reacting conditions at pH 7 and 35 C. CrCaf1 had similar activity when coordinated with Mg(2+) and Mn(2+), while the enzyme bound to Ca(2+) or Zn(2+) was almost inactivated.	Zinc	207-209	uncharacterized protein	Chlamydomonas reinhardtii	102-108
23936053-9	2013	Zn(2+) could induce CrCaf1 aggregation with the disruption of the native structure, while Mg(2+), Mn(2+) and Ca(2+) could stabilize CrCaf1 against thermal denaturation by reducing protein aggregation.	Zinc	0-6	uncharacterized protein	Chlamydomonas reinhardtii	20-26
23702591-8	2013	Inorganic contaminants at low levels, including Al, Mn, Zn, Pb, Cr, Cu, and Ni, were detected in tubercles and were concentrated in particulates from tap water following the release of iron during stagnation.	Zinc	56-58	nuclear RNA export factor 1	Homo sapiens	150-153
23542779-2	2013	The human heat shock protein 70 gene (hsp70) is activated by several heavy metals such as Cd and Zn, and the heat shock element (HSE) has been proposed to mediate metal response by previous studies.	Zinc	97-99	heat shock protein family A (Hsp70) member 4	Homo sapiens	38-43
23535854-1	2013	The use of the commercially available, bifunctional phosphine 1,3,5-triaza-7-phosphaadamantane (abbreviated as PN3) in conjunction with a series of Zn(salphen) complexes leads to sterically encumbered phosphine ligands as a result of (reversible) coordinative Zn-N interactions.	Zinc	260-264	sodium voltage-gated channel alpha subunit 10	Homo sapiens	111-114
23535854-3	2013	Also, upon application of these supramolecular bulky phosphines in hydrosilylation catalysis employing 1-hexene as a substrate, the catalysis data infer the presence of an active Rh species with two coordinated, bulky PN3/Zn(salphen) assembly units having a maximum of three Zn(salphen)s associated per PN3 scaffold, with an excess of bulky phosphines hardly affecting the overall activity.	Zinc	222-224	sodium voltage-gated channel alpha subunit 10	Homo sapiens	218-221
23535854-3	2013	Also, upon application of these supramolecular bulky phosphines in hydrosilylation catalysis employing 1-hexene as a substrate, the catalysis data infer the presence of an active Rh species with two coordinated, bulky PN3/Zn(salphen) assembly units having a maximum of three Zn(salphen)s associated per PN3 scaffold, with an excess of bulky phosphines hardly affecting the overall activity.	Zinc	222-224	sodium voltage-gated channel alpha subunit 10	Homo sapiens	303-306
23696812-2	2013	Increasing evidence has shown that matrix metalloproteinases (MMPs), a family of extracellularly acting and Zn(2+)-dependent endopeptidases, are able to rapidly modulate dendritic spine morphology.	Zinc	108-110	matrix metallopeptidase 9	Homo sapiens	62-66
23482562-14	2013	We found that isolated CtpC has metal-dependent ATPase activity with a strong preference for Mn(2+) over Zn(2+).	Zinc	105-107	ATPase	Escherichia coli	48-54
23208103-0	2013	Blue fluorescent protein analogs as chemosensors for Zn2+.	Zinc	53-57	ring finger protein 112	Homo sapiens	0-24
23208103-1	2013	Three chemosensors for Zn2+ were designed and synthesized based on the chromophore of the blue fluorescent protein (BFP).	Zinc	23-27	ring finger protein 112	Homo sapiens	90-114
23208103-1	2013	Three chemosensors for Zn2+ were designed and synthesized based on the chromophore of the blue fluorescent protein (BFP).	Zinc	23-27	ring finger protein 112	Homo sapiens	116-119
23208103-7	2013	Our work demonstrated the potentiality for the development of practical Zn2+ sensors based on the isolated BFP chromophores without the proteinframe.	Zinc	72-76	ring finger protein 112	Homo sapiens	107-110
23455330-5	2013	The origin of the magnetism induced by XZn-2VZn is similar to that of the Zn vacancy (VZn) in ZnO and comes from the O-2p orbitals dominantly.	Zinc	40-42	immunoglobulin kappa variable 1D-39	Homo sapiens	117-121
22825793-1	2013	This study is carried out to evaluate potentially toxic metal concentrations (As, Cd, Cr, Cu, Hg, Mo, Ni, Pb, and Zn) together with their spatial distribution, degree of pollution, and potential ecological risk in Kor river sediments (southwest Iran) using sediment quality guidelines, geoaccumulation index (I geo), Hakanson potential ecological risk index (RI), and standard methods of statistical analysis.	Zinc	114-116	opioid receptor kappa 1	Homo sapiens	214-217
22825793-4	2013	The potential ecological risk for nine investigated metals in Kor river is Hg (948) &gt; Mo (51.9) &gt; Ni (37.8) &gt; Cd (29.8) &gt; As (22) &gt; Cu (16.6) &gt; Pb (13.3) &gt; Zn (3.3) &gt; Cr (1).	Zinc	177-179	opioid receptor kappa 1	Homo sapiens	62-65
22640991-7	2013	The risk of higher levels of TNF-alpha, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0 63, 95% CI 0 42, 0 96, P= 0 03; OR 0 57, 95% CI 0 39, 0 86, P= 0 025; OR 0 63, 95% CI 0 41, 0 96, P= 0 04; OR 0 62, 95% CI 0 41, 0 95, P= 0 03, respectively).	Zinc	112-114	interleukin 10	Homo sapiens	46-51
23000319-9	2013	These results support the recently proposed inducible metalloprotease mechanism for TTR based on its 3D structure in presence of Zn(2+) and a series of point mutations [Liz et al., Biochem.	Zinc	129-131	transthyretin	Homo sapiens	84-87
23063975-2	2013	METHODS: Here we characterized the Zn(2+) induced TIM15 folding integrating biophysical and computational approaches.	Zinc	35-37	Zim17p	Saccharomyces cerevisiae S288C	50-55
23063975-4	2013	Moreover, we demonstrate unambiguously that Zn(2+) induced TIM15 folding is essential for its role as mtHsp70 chaperone since in the unstructured apo state TIM15 does not bind to mtHsp70 and is unable to prevent its aggregation.	Zinc	44-46	Zim17p	Saccharomyces cerevisiae S288C	59-64
23063975-4	2013	Moreover, we demonstrate unambiguously that Zn(2+) induced TIM15 folding is essential for its role as mtHsp70 chaperone since in the unstructured apo state TIM15 does not bind to mtHsp70 and is unable to prevent its aggregation.	Zinc	44-46	Zim17p	Saccharomyces cerevisiae S288C	156-161
23063975-5	2013	Molecular dynamics simulations help to understand the crucial role of Zn(2+) in promoting a stable and functional 3D architecture in TIM15.	Zinc	70-72	Zim17p	Saccharomyces cerevisiae S288C	133-138
23063975-7	2013	CONCLUSIONS: Zn(2+) induced TIM15 folding is essential for its function and likely occurs in mitochondrial matrix where high concentrations of Zn(2+) were reported.	Zinc	13-15	Zim17p	Saccharomyces cerevisiae S288C	28-33
23063975-7	2013	CONCLUSIONS: Zn(2+) induced TIM15 folding is essential for its function and likely occurs in mitochondrial matrix where high concentrations of Zn(2+) were reported.	Zinc	143-145	Zim17p	Saccharomyces cerevisiae S288C	28-33
23289009-8	2013	Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.	Zinc	19-21	CD8a molecule	Homo sapiens	113-116
22826039-4	2012	We found that Zn supplementation inhibited HG-induced RPMC apoptosis significantly, by attenuating reactive oxygen species (ROS) production, inhibiting HG-induced sFasR and sFasL over-expression, caspase-8 and caspase-3 activation, and inhibiting release of cytochrome c from mitochondria to the cytosol.	Zinc	14-16	caspase 8	Rattus norvegicus	196-205
22826039-6	2012	These results indicate that Zn can inhibit apoptosis in HG-induced RPMCs by several independent mechanisms, including an indirect antioxidative effect and probably by inhibition of caspase-8 and caspase-3 activation.	Zinc	28-30	caspase 8	Rattus norvegicus	181-190
22722772-6	2012	Interestingly, exogenously administered Zn(7)MT-3 increased soluble Abeta40 and Abeta42 and amyloid plaques and gliosis, particularly in the cortex, and changed several behavioral traits (increased deambulation and exploration and decreased anxiety).	Zinc	40-42	metallothionein 3	Homo sapiens	45-49
22932316-5	2012	The structural similarity between the potent HDAC inhibitor trichostatin A (TSA, 1; HDAC1, IC(50) 12nM) and the present compounds (2-7) was high at the Zn(II) coordinating hydroxamic acid head group; and in selected compounds (2, 5), at the 4-(dimethylamino)phenyl tail.	Zinc	152-154	histone deacetylase 9	Homo sapiens	45-49
23026089-11	2012	Finally, the combined treatment (Zn/Cd) also appears to cause enzyme inductions: CAT, APX and GST.	Zinc	33-35	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	86-89
22766378-3	2012	We present here an alternative approach to map and quantify Zn levels in the synapses from mossy fibers to CA3 region of the hippocampus.	Zinc	60-62	carbonic anhydrase 3	Rattus norvegicus	107-110
22674434-6	2012	For example, prominent beta-sheet formation in the N-terminal region (Asp1, Arg5, and Tyr10) of Zn:Abeta40 is significantly decreased or lacking in Zn:Abeta42.	Zinc	96-98	beta-secretase 2	Homo sapiens	70-74
22674434-6	2012	For example, prominent beta-sheet formation in the N-terminal region (Asp1, Arg5, and Tyr10) of Zn:Abeta40 is significantly decreased or lacking in Zn:Abeta42.	Zinc	148-150	beta-secretase 2	Homo sapiens	70-74
22415943-5	2012	We show that treatment of PC-3 prostate cancer and MDA-MB-231 breast cancer cells with these membrane-permeable Zn-chelators with different Zn affinities results in varying degrees of XIAP depletion.	Zinc	112-114	X-linked inhibitor of apoptosis	Homo sapiens	184-188
22415943-5	2012	We show that treatment of PC-3 prostate cancer and MDA-MB-231 breast cancer cells with these membrane-permeable Zn-chelators with different Zn affinities results in varying degrees of XIAP depletion.	Zinc	140-142	X-linked inhibitor of apoptosis	Homo sapiens	184-188
22415943-6	2012	Following decreased level of XIAP expression, we also show apoptosis-related caspase activation and cellular morphological changes upon treatment with strong Zn-chelators N4Py and BnTPEN.	Zinc	158-160	X-linked inhibitor of apoptosis	Homo sapiens	29-33
22706290-2	2012	Two families of Zn transporters - ZIP (SLC39) and ZnT (SLC30) - contribute to Zn homeostasis.	Zinc	16-18	death associated protein kinase 3	Homo sapiens	34-37
10923625-16	2000	Morphological evaluations revealed that Cd or Zn preincubation led to relative preservation of MAP2 staining and GFAP.	Zinc	46-48	glial fibrillary acidic protein	Homo sapiens	113-117
10891178-1	2000	Using this unprecedented methodology, AF4 is produced in 60% yield in a reaction of Zn with 0.35 M p-bis(chlorodifluoromethyl)benzene in DMA at 100 degrees C. The process comprises a convenient, inexpensive, and highly scaleable preparation of AF4 for both research and commercial purposes.	Zinc	84-86	AF4/FMR2 family member 1	Homo sapiens	38-41
10875441-6	2000	In contrast, the neuronal death induced by 50 microM Zn2+ was characterized by plasma membrane disruption and random DNA fragmentation; this death was attenuated by D-APV, but exhibited little sensitivity to ZVAD or deletion of bax.	Zinc	53-57	BCL2-associated X protein	Mus musculus	228-231
10644722-8	2000	Both human PBGS proteins purified with eight Zn(II)/octamer; Zn(II) binding was shown to be pH-dependent; and Pb(II) could displace some of the Zn(II).	Zinc	45-47	aminolevulinate dehydratase	Homo sapiens	11-15
22824090-6	2012	Compared to other members of the ZIP family identified in the Vitis vinifera L. genome, VvZIP3 is mainly expressed in reproductive tissue - specifically in developing flowers - which correlates with the high Zn accumulation in these organs.	Zinc	208-210	Argonaute family protein	Arabidopsis thaliana	33-36
22824090-10	2012	CONCLUSIONS: Our results suggest that VvZIP3 encodes a putative plasma membrane Zn transporter protein member of the ZIP gene family that might play a role in Zn uptake and distribution during the early reproductive development in Vitis vinifera L., indicating that the availability of this micronutrient may be relevant for reproductive development.	Zinc	80-82	Argonaute family protein	Arabidopsis thaliana	40-43
10644722-8	2000	Both human PBGS proteins purified with eight Zn(II)/octamer; Zn(II) binding was shown to be pH-dependent; and Pb(II) could displace some of the Zn(II).	Zinc	61-63	aminolevulinate dehydratase	Homo sapiens	11-15
10644722-8	2000	Both human PBGS proteins purified with eight Zn(II)/octamer; Zn(II) binding was shown to be pH-dependent; and Pb(II) could displace some of the Zn(II).	Zinc	61-63	aminolevulinate dehydratase	Homo sapiens	11-15
10564189-2	1999	Our results show that especially Zn(2+) and Cd(2+) are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs.	Zinc	33-35	heat shock protein family A (Hsp70) member 4	Homo sapiens	75-80
10564189-2	1999	Our results show that especially Zn(2+) and Cd(2+) are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs.	Zinc	33-35	heat shock protein family D (Hsp60) member 1	Homo sapiens	91-96
10406802-5	1999	We report here the cloning and characterization of an Arabidopsis thaliana transporter, designated AtMHX, which is localized in the vacuolar membrane and functions as an electrogenic exchanger of protons with Mg(2+) and Zn(2+) ions.	Zinc	220-222	magnesium/proton exchanger	Arabidopsis thaliana	99-104
10499288-3	1999	We have prepared complexes of HL1 and HL2 with Zn(II) and Cd(II).	Zinc	47-53	asialoglycoprotein receptor 1	Mus musculus	30-33
10499288-3	1999	We have prepared complexes of HL1 and HL2 with Zn(II) and Cd(II).	Zinc	47-53	asialoglycoprotein receptor 2	Mus musculus	38-41
10499288-4	1999	The cytotoxic activity shown by these compounds against cell lines sensitive and resistant to cis-diamminedichloroplatinum(II) (cis-DDP) indicates that coupling of HL1 and HL2 to Zn(II) and Cd(II) centers may result in metallic complexes with important biological properties since they display IC50 values in a microM range similar to that of the antitumor drug cis-DDP.	Zinc	179-185	asialoglycoprotein receptor 1	Mus musculus	164-167
10499288-4	1999	The cytotoxic activity shown by these compounds against cell lines sensitive and resistant to cis-diamminedichloroplatinum(II) (cis-DDP) indicates that coupling of HL1 and HL2 to Zn(II) and Cd(II) centers may result in metallic complexes with important biological properties since they display IC50 values in a microM range similar to that of the antitumor drug cis-DDP.	Zinc	179-185	asialoglycoprotein receptor 2	Mus musculus	172-175
18967666-6	1999	The developed methods were applied to Cu(II) and Zn(II) determination in natural and tap water.	Zinc	49-55	nuclear RNA export factor 1	Homo sapiens	85-88
10475631-5	1999	Phytase supplementation significantly improved the utilisation of N, P, Ca and Zn (as a percentage of intake) and increased the concentration of Ca and Zn in the tibiae (P&lt;0.05) because of higher intakes of dry matter, N, P, Ca and Zn.	Zinc	79-81	phytase	Zea mays	0-7
10475631-5	1999	Phytase supplementation significantly improved the utilisation of N, P, Ca and Zn (as a percentage of intake) and increased the concentration of Ca and Zn in the tibiae (P&lt;0.05) because of higher intakes of dry matter, N, P, Ca and Zn.	Zinc	152-154	phytase	Zea mays	0-7
10475631-5	1999	Phytase supplementation significantly improved the utilisation of N, P, Ca and Zn (as a percentage of intake) and increased the concentration of Ca and Zn in the tibiae (P&lt;0.05) because of higher intakes of dry matter, N, P, Ca and Zn.	Zinc	152-154	phytase	Zea mays	0-7
10362023-6	1999	These genes also showed differential responses in time course: more rapid induction was observed in the order of c-fos, hsp70, and MT-IIA after exposure to Zn or Cd.	Zinc	156-158	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
22667991-1	2012	Addition of the Lewis acid Zn(2+) to (TBP(8)Cz)Mn(V)(O) induces valence tautomerization, resulting in the formation of [(TBP(8)Cz(+ ))Mn(IV)(O)-Zn(2+)].	Zinc	27-29	TATA-box binding protein	Homo sapiens	38-41
22667991-1	2012	Addition of the Lewis acid Zn(2+) to (TBP(8)Cz)Mn(V)(O) induces valence tautomerization, resulting in the formation of [(TBP(8)Cz(+ ))Mn(IV)(O)-Zn(2+)].	Zinc	27-29	TATA-box binding protein	Homo sapiens	121-124
22367497-8	2012	The level of DIAP1 decreased significantly in haemocytes in the presence of high Zn(2+) concentration in comparison to untreated cells.	Zinc	81-87	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	13-18
22326910-1	2012	Matrix metalloproteinase-9 (MMP-9), an extracellularly acting, Zn(2+)-dependent endopeptidase is a subject to complex regulation at the level of transcription, mRNA dendritic translocation, and local translation as well as protein activation, as it is released extracellularly in a latent, pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity.	Zinc	63-69	matrix metallopeptidase 9	Homo sapiens	0-26
22326910-1	2012	Matrix metalloproteinase-9 (MMP-9), an extracellularly acting, Zn(2+)-dependent endopeptidase is a subject to complex regulation at the level of transcription, mRNA dendritic translocation, and local translation as well as protein activation, as it is released extracellularly in a latent, pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity.	Zinc	63-69	matrix metallopeptidase 9	Homo sapiens	28-33
22440330-9	2012	VrDhn1 exhibited low affinity for non-specific interaction with DNA using electrophoretic mobility shift assays (EMSAs), and the exogenous addition of Zn(2+) or Ni(2+) stimulated interaction.	Zinc	151-153	dehydrin DHN3	Vigna radiata	0-6
22294056-4	2012	Furthermore, the field-emission measurements show that the present ultralong ZnS nanowires arrays possess a low turn-on field of 3.69 V mum(-1) and a high field-enhancement factor of 1215.4, indicating they are valuable field emitters.	Zinc	77-80	PWWP domain containing 3A, DNA repair factor	Homo sapiens	136-142
10362023-6	1999	These genes also showed differential responses in time course: more rapid induction was observed in the order of c-fos, hsp70, and MT-IIA after exposure to Zn or Cd.	Zinc	156-158	heat shock protein family A (Hsp70) member 4	Homo sapiens	120-125
10398688-1	1999	The inactivation of the ClC-0 chloride channel is very temperature sensitive and is greatly facilitated by the binding of a zinc ion (Zn2+) from the extracellular side, leading to a Zn2+-induced current inhibition.	Zinc	134-138	Charcot-Leyden crystal galectin	Homo sapiens	24-27
10398688-1	1999	The inactivation of the ClC-0 chloride channel is very temperature sensitive and is greatly facilitated by the binding of a zinc ion (Zn2+) from the extracellular side, leading to a Zn2+-induced current inhibition.	Zinc	182-186	Charcot-Leyden crystal galectin	Homo sapiens	24-27
10398688-7	1999	These results further support the assertion that the inhibition of Zn2+ on ClC-0 is indeed due to an effect on the inactivation of the channel.	Zinc	67-71	Charcot-Leyden crystal galectin	Homo sapiens	75-78
10499817-5	1999	A Zn++ deficiency can lead to a premature transition from efficient Th1-dependent cellular antiviral immune functions to Th2-dependent humoral immune functions.	Zinc	2-6	negative elongation factor complex member C/D	Homo sapiens	68-71
10499817-6	1999	Deficiencies of Zn++, NO and/or GSH shift the Th1/Th2 balance towards Th2, as do deficiencies of any of the essential nutrients (ENs) - a group that includes methionine, cysteine, arginine, vitamins A, B, C and E, zinc and selenium (Se) - because these are necessary for the synthesis and maintenance of sufficient amounts of GSH, MT and NO.	Zinc	16-20	negative elongation factor complex member C/D	Homo sapiens	46-49
10499817-17	1999	Moreover, a sufficiency of Zn++ and NO prevents a shift of the Th1/Th2 balance towards Th2 and thereby slows the proliferation of HIV, which it also does by inactivating the HIV protease.	Zinc	27-31	negative elongation factor complex member C/D	Homo sapiens	63-66
10212220-2	1999	We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high affinity for Zn2+ as demonstrated by equilibrium dialyses.	Zinc	177-181	decorin	Bos taurus	18-25
10206982-1	1999	Currents through the human skeletal muscle chloride channel hClC-1 can be blocked by external application of 1 mM Zn2+ or the histidine-reactive compound diethyl pyrocarbonate (DEPC).	Zinc	114-118	chloride voltage-gated channel 1	Homo sapiens	60-66
10051656-4	1999	Further studies using the oxidation-sensitive dye, hydroethidine, revealed Zn2+-dependent reactive oxygen species (ROS) generation that paralleled the [Zn2+]i rises, with rapid oxidation observed only in the case of Zn2+ entry through Ca-A/K channels.	Zinc	75-79	teashirt zinc finger homeobox 1	Homo sapiens	235-241
10051656-6	1999	Additional evidence for a direct interaction between Zn2+ and mitochondria was provided by the observation that the Zn2+ entry through Ca-A/K channels triggered rapid mitochondrial depolarization, as assessed by using the potential-sensitive dye tetramethylrhodamine ethylester.	Zinc	53-57	teashirt zinc finger homeobox 1	Homo sapiens	135-141
10051656-6	1999	Additional evidence for a direct interaction between Zn2+ and mitochondria was provided by the observation that the Zn2+ entry through Ca-A/K channels triggered rapid mitochondrial depolarization, as assessed by using the potential-sensitive dye tetramethylrhodamine ethylester.	Zinc	116-120	teashirt zinc finger homeobox 1	Homo sapiens	135-141
11711061-2	1998	To elucidate the role for proline in plant responses to heavy metal stress, we studied the effect of proline on Cd-induced and Zn-induced inhibition of glucose-6-phosphate dehydrogenase (G-6-PDH; EC 1.1.1.49) and nitrate reductase (NR; EC 1.6.6.2) in vitro.	Zinc	127-129	glucose-6-phosphate dehydrogenase	Homo sapiens	152-185
11711061-2	1998	To elucidate the role for proline in plant responses to heavy metal stress, we studied the effect of proline on Cd-induced and Zn-induced inhibition of glucose-6-phosphate dehydrogenase (G-6-PDH; EC 1.1.1.49) and nitrate reductase (NR; EC 1.6.6.2) in vitro.	Zinc	127-129	glucose-6-phosphate dehydrogenase	Homo sapiens	187-194
9794920-4	1998	Transport was studied with enalapril (1 to 800 micromol/L, with [3H]enalapril) in a HeLa cell line stably transfected with oatp1-cDNA under the regulation of a Zn2+-inducible promoter.	Zinc	160-164	ornithine aminotransferase pseudogene 1	Homo sapiens	123-128
9728050-6	1998	Similarly, the transcription factors c-Jun and ATF-2, substrates of JNK and P38, respectively, were markedly phosphorylated in BEAS cells treated with As, Cr, Cu, V, and Zn.	Zinc	170-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
9728050-6	1998	Similarly, the transcription factors c-Jun and ATF-2, substrates of JNK and P38, respectively, were markedly phosphorylated in BEAS cells treated with As, Cr, Cu, V, and Zn.	Zinc	170-172	activating transcription factor 2	Homo sapiens	47-52
9783327-2	1998	ALA-D inhibition by 2,3-dimercaptopropanol was totally reversed by 25-100 microM Zn2+, indicating that inhibition was due to chelation of zinc by 2,3-dimercaptopropanol.	Zinc	81-85	aminolevulinate dehydratase	Homo sapiens	0-5
9783327-7	1998	Taken together, these results suggest that 2,3-dimercaptopropanol inhibits ALA-D by chelating Zn2+ from a labile site that is involved in maintaining enzyme sulfhydryl groups in a reduced state.	Zinc	94-98	aminolevulinate dehydratase	Homo sapiens	75-80
9501139-7	1998	Expression studies with the Fe2+ transporter cloned from Arabidopsis, IRT1, indicated that Fe deficiency induced the expression of this transporter, which might facilitate the transport of heavy-metal divalent cations such as Cd2+ and Zn2+, in addition to Fe2+.	Zinc	236-240	iron-regulated transporter 1	Arabidopsis thaliana	71-75
9452440-2	1998	Fluorescent and non-fluorescent probes have been used to show that divalent cations (Ca2+, Mg2+, Mn2+, and Zn2+) significantly increase hydrophobic exposure on GroEL, whereas monovalent cations (K+ and Na+) have little effect.	Zinc	107-111	heat shock protein family D (Hsp60) member 1	Homo sapiens	160-165
9452440-3	1998	Zn2+ always induced the largest amount of hydrophobic exposure on GroEL.	Zinc	0-4	heat shock protein family D (Hsp60) member 1	Homo sapiens	66-71
9452440-4	1998	By using a new method based on interactions of GroEL with octyl-Sepharose, it was demonstrated that Zn2+ binding strengthens GroEL hydrophobic binding interactions and increases the efficiency of substrate release upon the addition of MgATP and GroES.	Zinc	100-104	heat shock protein family D (Hsp60) member 1	Homo sapiens	47-52
9452440-4	1998	By using a new method based on interactions of GroEL with octyl-Sepharose, it was demonstrated that Zn2+ binding strengthens GroEL hydrophobic binding interactions and increases the efficiency of substrate release upon the addition of MgATP and GroES.	Zinc	100-104	heat shock protein family D (Hsp60) member 1	Homo sapiens	125-130
9452440-5	1998	The binding of 4, 4"-bis(1-anilino-8-naphthalenesulfonic acid) to GroEL in the presence of Zn2+ has a Kd congruent with 1 microM, which is similar to that observed previously for the GroEL 4, 4"-bis(1-anilino-8-naphthalenesulfonic acid) complex.	Zinc	91-95	heat shock protein family D (Hsp60) member 1	Homo sapiens	66-71
22417133-2	2012	This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37  C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4.	Zinc	132-134	elastin	Homo sapiens	20-27
9452440-5	1998	The binding of 4, 4"-bis(1-anilino-8-naphthalenesulfonic acid) to GroEL in the presence of Zn2+ has a Kd congruent with 1 microM, which is similar to that observed previously for the GroEL 4, 4"-bis(1-anilino-8-naphthalenesulfonic acid) complex.	Zinc	91-95	heat shock protein family D (Hsp60) member 1	Homo sapiens	183-188
9452440-6	1998	Urea denaturation, sedimentation velocity ultracentrifugation, and electron microscopy revealed that the quaternary structure of GroEL in the presence of Zn2+ had a stability and morphology equivalent to unliganded GroEL.	Zinc	154-158	heat shock protein family D (Hsp60) member 1	Homo sapiens	129-134
9452440-9	1998	Furthermore, the influence of Zn2+ on GroEL hydrophobic surface exposure as well as substrate binding and release appears to be distinct from the stabilizing effects of Mg2+ on GroEL quaternary structure.	Zinc	30-34	heat shock protein family D (Hsp60) member 1	Homo sapiens	38-43
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	Zinc	174-178	putative Mg(2+) transporter ALR2	Saccharomyces cerevisiae S288C	55-59
22533418-5	2012	Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently.	Zinc	0-2	tRNA glycine, mitochondrial	Mus musculus	50-55
9507061-1	1998	The endogenous cation, Zn2+, is synaptically released and may trigger neurodegeneration after permeating through NMDA channels, voltage sensitive Ca2+ channels (VSCC), or Ca2+ permeable AMPA/kainate channels (Ca-A/K).	Zinc	23-27	teashirt zinc finger homeobox 1	Homo sapiens	209-215
9507061-3	1998	The primary objective of this study was to determine whether a similar approach could be employed to visualize agonist-stimulated intracellular Zn2+ accumulation, and, thus, to test the hypothesis that Ca-A/K permit particularly rapid Zn2+ flux.	Zinc	235-239	teashirt zinc finger homeobox 1	Homo sapiens	202-208
9543248-10	1998	Incubation of rat aortic smooth muscle cells and bovine pulmonary artery endothelial cell co-cultures with Zn2+ (150 microM) caused a significant reduction in basal and bradykinin- or A-23187-induced formation of cGMP.	Zinc	107-111	kininogen 1	Bos taurus	169-179
29576664-3	2012	It was observed that the Zn concentration is highly correlated with S and Fe and Ca with Sr in common bean seed.	Zinc	25-27	brain expressed associated with NEDD4 1	Homo sapiens	102-106
22139846-5	2012	Unlike its close relative AtMTP1, which is highly selective for Zn(2+), HvMTP1 exhibits selectivity for both Zn(2+) and Co(2+) as assessed by its ability to suppress yeast mutant phenotypes for both metals.	Zinc	64-66	putative Zn transporter	Hordeum vulgare	72-78
22139846-5	2012	Unlike its close relative AtMTP1, which is highly selective for Zn(2+), HvMTP1 exhibits selectivity for both Zn(2+) and Co(2+) as assessed by its ability to suppress yeast mutant phenotypes for both metals.	Zinc	64-70	putative Zn transporter	Hordeum vulgare	72-78
9543248-11	1998	Thus, our results indicate that Zn2+ is capable of inhibiting lipopolysaccharide- or interleukin-1beta-induced NO formation as well as NO formation by constitutive NO synthase basally or in response to bradykinin or A-23187, and may explain the reported anti-inflammatory activity of Zn2+.	Zinc	32-36	kininogen 1	Bos taurus	202-212
22139846-6	2012	Expression of HvMTP1/AtMTP1 chimeras in yeast revealed a five-residue sequence within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+).	Zinc	174-176	putative Zn transporter	Hordeum vulgare	14-20
9649687-3	1998	The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes.	Zinc	68-70	intercellular adhesion molecule 1	Homo sapiens	161-167
9256278-3	1997	Although the interaction of Zn2+ with this neurotrophin has previously been suggested, the direct actions of the ion on NGF function have not been explored.	Zinc	28-32	brain derived neurotrophic factor	Homo sapiens	43-55
9256278-4	1997	Molecular modeling studies predict that Zn2+ binding to NGF will induce structural changes within domains of this neurotrophin that participate in the recognition of TrkA and p75NTR.	Zinc	40-44	brain derived neurotrophic factor	Homo sapiens	114-126
9256278-6	1997	Similar actions of Zn2+ are also observed with other members of the NGF family, suggesting a modulatory role for this metal ion in neurotrophin function.	Zinc	19-23	brain derived neurotrophic factor	Homo sapiens	131-143
9295238-6	1997	Exposure of HPT cells to either Zn2+ or Cd2+ resulted in an early (within 24 h), but unsustained increase in MT-3 mRNA.	Zinc	32-36	metallothionein 3	Homo sapiens	109-113
9211591-6	1997	The blood porphobilinogen deaminase (PBG-D) activity in the Zn group was slightly less than that in the controls.	Zinc	60-62	hydroxymethylbilane synthase	Mus musculus	10-35
9211591-6	1997	The blood porphobilinogen deaminase (PBG-D) activity in the Zn group was slightly less than that in the controls.	Zinc	60-62	hydroxymethylbilane synthase	Mus musculus	37-42
9211591-9	1997	The splenic PBG-D activities were markedly higher in the Be and/or Zn groups than in the controls.	Zinc	67-69	hydroxymethylbilane synthase	Mus musculus	12-17
9211591-11	1997	Furthermore, the increase in PBG-D activities in liver and spleen was observed in the Be and/or Zn groups.	Zinc	96-98	hydroxymethylbilane synthase	Mus musculus	29-34
9173905-2	1997	The metal depletion of a glutathione S-transferase (GST)-M96 fusion protein showed that Zn2+ ions modulate the MRE-binding activity, suggesting that the M96-encoded protein is a Zn2+-regulated factor (ZiRF1).	Zinc	88-92	metal response element binding transcription factor 2	Mus musculus	201-206
9064653-4	1997	With the mutant channel hClC-1 D136G, presumed to have a defective voltage sensor, external Zn2+ also reduced the current without effect on the altered gating.	Zinc	92-96	chloride voltage-gated channel 1	Homo sapiens	24-30
21360559-6	2012	Zn and/or Cd treatment increased hepatic delta-ALA-D activity, although the increase caused by Cd was less marked.	Zinc	0-2	aminolevulinate dehydratase	Homo sapiens	41-52
21360559-7	2012	Reactivation index of delta-ALA-D by DTT was decreased by Zn and Cd exposure, which indicates that Zn protects enzyme from oxidation.	Zinc	58-60	aminolevulinate dehydratase	Homo sapiens	22-33
21360559-7	2012	Reactivation index of delta-ALA-D by DTT was decreased by Zn and Cd exposure, which indicates that Zn protects enzyme from oxidation.	Zinc	99-101	aminolevulinate dehydratase	Homo sapiens	22-33
21360559-9	2012	The results presented here indicate that Cd can redistribute Zn from non-hepatic tissues to liver and the increase in hepatic Zn deposition can account for the increase in hepatic delta-ALA-D activity after Cd exposure.	Zinc	126-128	aminolevulinate dehydratase	Homo sapiens	180-191
21603979-6	2012	Gene silencing of ZIP2 and ZIP4 in RPE cells from young donors or their overexpression in cells from older donors confirms that these two transporters are essential in controlling Zn(2+) influx and sequestration in RPE cells.	Zinc	180-182	solute carrier family 39 member 4	Homo sapiens	27-31
8969229-9	1996	Vps8p contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif.	Zinc	100-104	CORVET complex membrane-binding subunit VPS8	Saccharomyces cerevisiae S288C	0-5
8737837-6	1996	Phytase supplementation of the low-P diet increased (P &lt; or = 0.05) the relative retention of total P, Ca, Cu, and Zn by 12.5, 12.2, 19.3, and 62.3 percentage units, respectively, in male chickens.	Zinc	118-120	putative glycerophosphoryl diester phosphodiesterase	Glycine max	0-7
8737837-10	1996	These results show that microbial phytase supplementation of a low-P diet increased growth and relative retention of total P, Ca, Cu, and Zn and improved bone mineralization in broiler chickens.	Zinc	138-140	putative glycerophosphoryl diester phosphodiesterase	Glycine max	34-41
8745276-23	1996	The divalent and trivalent cations Cd2+, Co2+, Ni2+, Zn2+ and La3+ shifted the activation of INa to more positive potentials and decreased the maximal conductance in a dose-dependent manner.	Zinc	53-57	internexin neuronal intermediate filament protein, alpha	Mus musculus	93-96
8745276-24	1996	The apparent Kd values for blockade of the INa by Cd2+, Co2+, Ni2+, Zn2+ and La3+ were 430, 3500, 1900, 83 and 202 microM, respectively.	Zinc	68-72	internexin neuronal intermediate filament protein, alpha	Mus musculus	43-46
7591296-5	1995	The down-modulation was strengthened by Zn2+ or Cd2+, but not by other divalent cations such as Fe2+, Mn2+, Mg2+, Ca2+ or Co2+, thus indicating the involvement of a zinc metalloproteinase in CD30 modulation which can be activated by protein kinase C and by alkylation of sulfhydryl groups.	Zinc	40-44	TNF receptor superfamily member 8	Homo sapiens	191-195
8529638-1	1995	Porphobilinogen synthase activity has been measured in human erythrocyte lysates supplemented with metal-ion buffers to control free Zn2+ and Pb2+ concentrations.	Zinc	133-137	aminolevulinate dehydratase	Homo sapiens	0-24
8537816-8	1995	For the Cys mutant of mu 1 and also for the cardiac isoform Na channel (rh1) expressed in the L6 rat muscle cell line, inhibition of macroscopic Na+ conductance by Zn2+ reached a plateau at 85-90% inhibition, suggesting the presence of a substate current.	Zinc	164-168	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	22-26
7626590-5	1995	Among pyrimidine-catabolizing enzymes, dihydropyrimidinase (EC 3.5.2.2) activity showed significant retardation in the Zn-deficient rat liver with decrease of the enzyme protein.	Zinc	119-121	dihydropyrimidinase	Rattus norvegicus	39-58
7726852-0	1995	Zn2+ binding to cardiac calsequestrin.	Zinc	0-4	calsequestrin 2	Canis lupus familiaris	16-37
7726852-1	1995	Zn2+ binding to canine cardiac calsequestrin was investigated using the Zn2+ specific fluorescence dye salicylcarbohydrazone (SACH), 65Zn2+ overlay and Zn(2+)-IDA chromatography.	Zinc	0-4	calsequestrin 2	Canis lupus familiaris	23-44
7726852-1	1995	Zn2+ binding to canine cardiac calsequestrin was investigated using the Zn2+ specific fluorescence dye salicylcarbohydrazone (SACH), 65Zn2+ overlay and Zn(2+)-IDA chromatography.	Zinc	72-76	calsequestrin 2	Canis lupus familiaris	23-44
7733291-7	1995	Inactivation of AP by cleavage of its membrane anchor and by removal of the Zn2+ necessary for its function left the ecto-ATPase that was activated by Ca2+ and Mg2+ and hydrolyzed purine and pyrimidine trinucleotides and dinucleotides, but not AMP, pyrophosphate, and 4-nitrophenylphosphate.	Zinc	76-80	CEA cell adhesion molecule 1	Rattus norvegicus	117-128
22050230-9	2011	NH(4)Cl increased peripheral-type benzodiazepine receptor (PBR) protein expression, whereas PBR mRNA levels were decreased in a Zn(2+)-independent manner.	Zinc	128-130	translocator protein	Rattus norvegicus	92-95
7836451-9	1995	In contrast, pHi recovery in high K+ medium was largely attributed to a Zn(2+)-sensitive proton conductive pathway.	Zinc	72-78	glucose-6-phosphate isomerase	Oryctolagus cuniculus	13-16
7890805-3	1994	The signal is likely independent of protein kinase C, but depends on tyrosine kinase and other kinase activities and is mediated by c-Ha-Ras since the presence of dominant-negative mutants of Ras and Raf abrogates the induction of Egr-1 expression by Zn2+.	Zinc	251-255	Harvey rat sarcoma virus oncogene	Mus musculus	132-140
7947824-0	1994	Grafting of a high-affinity Zn(II)-binding site on the beta-barrel of retinol-binding protein results in enhanced folding stability and enables simplified purification.	Zinc	28-34	retinol binding protein 4	Homo sapiens	70-93
7947824-1	1994	In a rational protein design approach, the His3 Zn(II)-binding site from the active center of human carbonic anhydrase II was transplanted on the beta-barrel of mammalian serum retinol-binding protein (RBP) in a solvent-accessible location on the protein"s outer surface.	Zinc	48-54	carbonic anhydrase 2	Homo sapiens	100-121
7947824-1	1994	In a rational protein design approach, the His3 Zn(II)-binding site from the active center of human carbonic anhydrase II was transplanted on the beta-barrel of mammalian serum retinol-binding protein (RBP) in a solvent-accessible location on the protein"s outer surface.	Zinc	48-54	retinol binding protein 4	Homo sapiens	177-200
7947824-1	1994	In a rational protein design approach, the His3 Zn(II)-binding site from the active center of human carbonic anhydrase II was transplanted on the beta-barrel of mammalian serum retinol-binding protein (RBP) in a solvent-accessible location on the protein"s outer surface.	Zinc	48-54	retinol binding protein 4	Homo sapiens	202-205
7947824-2	1994	Several mutants of RBP were generated and produced in Escherichia coli, and their Zn(II)-binding properties were investigated in equilibrium dialysis experiments.	Zinc	82-88	retinol binding protein 4	Homo sapiens	19-22
7947824-3	1994	One mutant, RBP/H3(A), with His residues introduced at the positions 46, 54, and 56 in the polypeptide sequence was shown to bind Zn(II) specifically with a stoichiometry of 1 and a corresponding dissociation constant equal to 36 +/- 10 nM.	Zinc	130-132	retinol binding protein 4	Homo sapiens	12-15
7525551-7	1994	Using fluorimetric determinations of pHi, a conductive, Zn(2+)-sensitive alkalinization was observed in neutrophils from both normal and cytochrome b-deficient CGD donors.	Zinc	56-62	mitochondrially encoded cytochrome b	Homo sapiens	137-149
7918369-0	1994	5-Chloro[1,4-13C]levulinic acid modification of mammalian and bacterial porphobilinogen synthase suggests an active site containing two Zn(II).	Zinc	136-138	aminolevulinate dehydratase	Homo sapiens	72-96
8076694-2	1994	The present study reports the details of the zinc-metalloprotein nature of TP2 by employing the 65 Zn-blotting technique.	Zinc	99-101	transition protein 2	Rattus norvegicus	75-78
7749371-7	1994	While Ca(II) did not replace Zn(II) as an activator it significantly enhanced Zn(II)- and P(i)-dependent activation of FXII.	Zinc	78-84	carbonic anhydrase 2	Homo sapiens	6-12
8307005-13	1994	The Ki for Zn2+ as an inhibitor of DHPase was 23 microM, and the maximum rate of inactivation was 0.057 min-1 at 37 degrees C. H2Ura and H2Thy protected the enzyme activity from Zn2+ inactivation.	Zinc	11-15	dihydropyrimidinase	Rattus norvegicus	35-41
8307005-13	1994	The Ki for Zn2+ as an inhibitor of DHPase was 23 microM, and the maximum rate of inactivation was 0.057 min-1 at 37 degrees C. H2Ura and H2Thy protected the enzyme activity from Zn2+ inactivation.	Zinc	178-182	dihydropyrimidinase	Rattus norvegicus	35-41
8241506-7	1993	Platelet activation with Zn+2 also enhanced GPIIb and GPIIIa recovery on fibrinogen-coated surfaces over that observed with unstimulated platelets, but GPIIb and IIIa retention was EDTA sensitive.	Zinc	25-29	integrin subunit alpha 2b	Homo sapiens	44-49
8504099-8	1993	On the basis of these similarities, yeast AMP deaminase is also proposed to use a Zn(2+)-activated water molecule to attack C6 of AMP with the displacement of NH3.	Zinc	82-88	AMP deaminase	Saccharomyces cerevisiae S288C	42-55
8503871-3	1993	Micromolar concentrations of Mn2+, Fe2+ and, to a lesser extent, of Zn2+ and Co2+ were shown to stimulate PEPCK activity.	Zinc	68-72	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	106-111
7682829-8	1993	Zn tended to increase in all tissues, except in the spleen, where during the acute phase of the infection, the total content of Zn in groups L-1 and L-2 was lower than in group C. Cu increased mainly in the spleen and muscle.	Zinc	128-130	ribosomal protein L4	Rattus norvegicus	141-144
8452534-4	1993	Lysosomal ADA was completely inhibited by 2.5 mM Cu2+ or Hg2+ salts, but not by other bivalent cations (Ba2+, Cd2+, Ca2+, Fe2+, Mg2+, Mn2+ and Zn2+).	Zinc	143-147	adenosine deaminase	Homo sapiens	10-13
8382991-11	1993	SL-MMTS-modified PBGS loses all Zn(II) and cannot catalyze product formation.	Zinc	32-34	aminolevulinate dehydratase	Homo sapiens	17-21
1379555-4	1992	Cyanogen bromide cleavage of p60c-src phosphorylated in the presence of Zn2+ yields a 4-kDa phosphopeptide corresponding to phosphorylation of a carboxy-terminal tyrosine residue of Src kinase.	Zinc	72-76	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	34-37
1379555-4	1992	Cyanogen bromide cleavage of p60c-src phosphorylated in the presence of Zn2+ yields a 4-kDa phosphopeptide corresponding to phosphorylation of a carboxy-terminal tyrosine residue of Src kinase.	Zinc	72-76	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	182-185
1379555-5	1992	In conclusion, hippocampal membranes contain a Zn(2+)-stimulated protein tyrosine kinase capable of regulating the p60c-src activity.	Zinc	47-53	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	120-123
1602138-6	1992	Zn2+ also prevented Leu-Leu-OMe-mediated killing of normal human CD16+ NK cells.	Zinc	0-4	Fc gamma receptor IIIa	Homo sapiens	65-69
1577805-6	1992	The novel enzyme is further differentiated from the major lysosomal alpha-mannosidase by its inability to catalyze the efficient hydrolysis of the synthetic substrate p-nitrophenyl alpha-mannoside, and by the strong stimulation of its activity by Co2+ and Zn2+.	Zinc	256-260	mannosidase alpha class 2B member 1	Homo sapiens	58-85
1348524-1	1992	c-fos mRNA and Fos-like protein(s) (FLP) are induced in cultured cortical neurons by glutamate, high K+, phorbol ester, basic fibroblast growth factor, Zn2+, and vasoactive intestinal peptide.	Zinc	152-156	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
1348524-1	1992	c-fos mRNA and Fos-like protein(s) (FLP) are induced in cultured cortical neurons by glutamate, high K+, phorbol ester, basic fibroblast growth factor, Zn2+, and vasoactive intestinal peptide.	Zinc	152-156	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-18
1561009-9	1992	Immunoaffinity and Zn(II) affinity isolation of HRG from colostrum and milk resulted in the copurification of several associated proteins.	Zinc	19-21	histidine rich glycoprotein	Homo sapiens	48-51
21791082-12	2011	Furthermore, The SPLA2 activity was dependent on Ca2+; other cations (Mg2+, Mn2+, Cd2+ and Zn2+) reduced the enzymatic activity notably, suggesting that the arrangement of the catalytic site presents an exclusive structure for Ca2+.	Zinc	91-95	phospholipase A2 group IIA	Homo sapiens	17-22
21602277-2	2011	Here we used patch clamp recording to study the effects of Zn(2+) on the melastatin transient receptor potential 2 (TRPM2) channel.	Zinc	59-61	transient receptor potential cation channel subfamily M member 2	Homo sapiens	116-121
21602277-3	2011	Zn(2+) inhibited the human (h) TRPM2 channel currents, and the steady-state inhibition was largely not reversed upon washout and concentration-independent in the range of 30-1000 muM, suggesting that Zn(2+) induces channel inactivation.	Zinc	0-5	transient receptor potential cation channel subfamily M member 2	Homo sapiens	31-36
21602277-3	2011	Zn(2+) inhibited the human (h) TRPM2 channel currents, and the steady-state inhibition was largely not reversed upon washout and concentration-independent in the range of 30-1000 muM, suggesting that Zn(2+) induces channel inactivation.	Zinc	0-6	transient receptor potential cation channel subfamily M member 2	Homo sapiens	31-36
21602277-5	2011	Alanine substitution scanning mutagenesis of 20 Zn(2+)-interacting candidate residues in the outer pore region of the hTRPM2 channel showed that mutation of Lys(952) in the extracellular end of the fifth transmembrane segment and Asp(1002) in the large turret strongly attenuated or abolished Zn(2+) inactivation, and mutation of several other residues dramatically changed the inactivation kinetics.	Zinc	48-50	transient receptor potential cation channel subfamily M member 2	Homo sapiens	118-124
21602277-5	2011	Alanine substitution scanning mutagenesis of 20 Zn(2+)-interacting candidate residues in the outer pore region of the hTRPM2 channel showed that mutation of Lys(952) in the extracellular end of the fifth transmembrane segment and Asp(1002) in the large turret strongly attenuated or abolished Zn(2+) inactivation, and mutation of several other residues dramatically changed the inactivation kinetics.	Zinc	293-295	transient receptor potential cation channel subfamily M member 2	Homo sapiens	118-124
21602277-6	2011	The mouse (m) TRPM2 channels were also inactivated by Zn(2+), but the kinetics were remarkably slower.	Zinc	54-56	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	14-19
21602277-8	2011	We conclude from these results that Zn(2+) inactivates the TRPM2 channels and that residues in the outer pore are critical determinants of the inactivation.	Zinc	36-42	transient receptor potential cation channel subfamily M member 2	Homo sapiens	59-64
21678940-6	2011	Films consisting of the Zn ion complex of P-1 and ABTS are yellow in the neutral state and change their color to brownish gray and finally blue, if anodically oxidized at ~640 mV vs FOC.	Zinc	24-26	crystallin gamma F, pseudogene	Homo sapiens	42-45
21678940-7	2011	Films containing the Zn ion complex of P-1, with P-2 as a counterion, are yellow in the neutral state and change color to dark red and finally blue, if anodically oxidized at ~450 mV vs FOC.	Zinc	21-23	crystallin gamma F, pseudogene	Homo sapiens	39-42
21678940-8	2011	Compared with previously reported films of the Zn ion complex of P-1 with nonelectroactive hexafluorophosphate as the counterion, the new films exhibit faster response times, as well as higher contrast, and the colors in the oxidized state are modified.	Zinc	47-49	crystallin gamma F, pseudogene	Homo sapiens	65-68
21300396-0	2011	Leaching of Cu and Zn from discarded boat paint particles into tap water and rain water.	Zinc	19-21	nuclear RNA export factor 1	Homo sapiens	63-66
21414325-2	2011	We have determined the atomic structure of the soluble domain of CnrX in its Ni-bound, Co-bound, or Zn-bound form.	Zinc	100-102	periplasmic nickel sensor	Cupriavidus metallidurans CH34	65-69
21312334-2	2011	Low-molecular-weight nonpeptidic compounds, including AMD3100 and various pyridyl macrocyclic zinc(II) complexes, have been identified as selective antagonists of CXCR4.	Zinc	94-102	C-X-C motif chemokine receptor 4	Homo sapiens	163-168
21312334-4	2011	Several new zinc(II) or copper(II) complexes demonstrated potent anti-HIV activity, strong CXCR4-binding activity, and significant inhibitory activity against Ca(2+) mobilization induced by CXCL12 stimulation.	Zinc	12-20	C-X-C motif chemokine receptor 4	Homo sapiens	91-96
21425789-4	2011	With the purpose of identifying which is the most efficient dimetallic center for the prolidase catalyzed reaction, Zn(II), Co(II), and Mn(II) have been examined as potential catalytic metals for this enzyme.	Zinc	116-122	peptidase D	Homo sapiens	86-95
21388211-2	2011	Depending on the position of the C-Zn bond relative to the nitrogen (position 2 vs position 4), the stereoselectivity of the coupling can be directed toward either the trans- or cis-2,4-disubstituted products.	Zinc	35-37	suppressor of cytokine signaling 2	Homo sapiens	178-183
21467744-3	2011	Previously, we had reported that Zn induced the formation of a co-activator complex containing metal response element-binding transcription factor-1 (MTF-1) and the histone acetyltransferase (HAT), p300, which plays an essential role in the activation of MT-1 transcription.	Zinc	33-35	E1A binding protein p300	Mus musculus	198-202
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	47-49	E1A binding protein p300	Mus musculus	131-135
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	95-97	E1A binding protein p300	Mus musculus	131-135
21445361-5	2011	We conclude that SLC39A14 facilitates GPCR-mediated cAMP-CREB signaling by suppressing the basal PDE activity, and that this is one mechanism for Zn"s involvement in systemic growth processes.	Zinc	146-148	G protein-coupled receptor 34	Mus musculus	38-42
21097531-6	2011	Zn supplementation reduced tumor burdens by 28% (wild-type) to 42% (Fhit-/-Nit1-/-).	Zinc	0-2	nitrilase 1	Mus musculus	75-79
20967475-0	2011	Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.	Zinc	127-135	BRCA1 DNA repair associated	Homo sapiens	71-76
20967475-5	2011	An unprecedented D67E BRCA1 mutation, identified in Thai familial breast cancer patients, is located in the vicinity of Zn(2+) binding site II, and its pathogenic significance remains elusive.	Zinc	120-126	BRCA1 DNA repair associated	Homo sapiens	22-27
20967475-6	2011	The present study revealed that the D67E BRCA1 RING protein assumes a preformed structure in the absence of Zn(2+).	Zinc	108-110	BRCA1 DNA repair associated	Homo sapiens	41-46
21253395-8	2011	Similarly, ileal lactase activities were higher in MT-/- (1480 +- 192) compared with MT+/+ (629 +- 353) mice particularly those fed the 2 Zn diet.	Zinc	138-140	lactase	Mus musculus	17-24
21389614-2	2011	We found novel roles of RPT2a and RPT5a in Zn deficiency-tolerance.	Zinc	43-45	regulatory particle triple-A ATPase 5A	Arabidopsis thaliana	34-39
21389614-3	2011	Arabidopsis thaliana mutants carrying T-DNA in RPT2a and RPT5a were more sensitive to Zn deficiency than the wild-type.	Zinc	86-88	regulatory particle triple-A ATPase 5A	Arabidopsis thaliana	57-62
20858712-1	2010	Zinc transporter 2 (ZnT2) plays a major role in zinc (Zn) export from the mammary gland.	Zinc	20-22	solute carrier family 30 member 2	Homo sapiens	0-18
20629007-3	2010	The crystal structure of hCA II in complex with one such fragment reveals a bidentate binding mode with a trigonal-bipyramidal coordination geometry at the Zn(2+) center.	Zinc	156-158	carbonic anhydrase 2	Homo sapiens	25-31
1346974-4	1992	Native octameric PBGS binds eight substrate molecules and eight Zn(II) ions, with two types of sites for each ligand.	Zinc	64-70	aminolevulinate dehydratase	Homo sapiens	17-21
1346974-8	1992	Here we report that 5-CLA-modified PBGS (5-CLA-PBGS) can bind up to four substrate molecules and four Zn(II) ions.	Zinc	102-104	aminolevulinate dehydratase	Homo sapiens	35-39
1346974-8	1992	Here we report that 5-CLA-modified PBGS (5-CLA-PBGS) can bind up to four substrate molecules and four Zn(II) ions.	Zinc	102-104	aminolevulinate dehydratase	Homo sapiens	47-51
1567990-1	1992	Cod parvalbumin, a calcium-binding protein, possesses a specific Zn2+ (or Cu2+) binding site per molecule.	Zinc	65-69	parvalbumin	Homo sapiens	4-15
20806985-1	2010	The dopamine transporter is regulated by zinc (Zn2+), which directly interacts with the transporter protein as a potent non-competitive blocker of substrate translocation (dopamine transport inward and outward).	Zinc	47-51	solute carrier family 6 member 3	Homo sapiens	4-24
20492471-8	2010	Immunoblots for FXa and functional assays showed that Zn2(+) -containing PS inhibited primarily the quantity of FXa formed by tissue factor (TF)-FVIIa, rather than FXa amidolytic activity.	Zinc	54-60	coagulation factor X	Homo sapiens	16-19
20492471-8	2010	Immunoblots for FXa and functional assays showed that Zn2(+) -containing PS inhibited primarily the quantity of FXa formed by tissue factor (TF)-FVIIa, rather than FXa amidolytic activity.	Zinc	54-60	coagulation factor X	Homo sapiens	112-115
20492471-8	2010	Immunoblots for FXa and functional assays showed that Zn2(+) -containing PS inhibited primarily the quantity of FXa formed by tissue factor (TF)-FVIIa, rather than FXa amidolytic activity.	Zinc	54-60	coagulation factor X	Homo sapiens	112-115
20679226-3	2010	Preventing the coordination of Zn(2+) ions by amino acid substitutions in PEX10, PEX2, and PEX12 and overexpressing the resulting conditional sublethal mutations in WT uncovered additional functions of PEX10.	Zinc	31-33	Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein	Arabidopsis thaliana	81-85
20553223-6	2010	Zn and/or PQ exposure increased gene expression of DAT, CYP2E1, GSTA4-4, MT-I and MT-II, but reduced the expression of VMAT-2.	Zinc	0-2	solute carrier family 18 member A2	Rattus norvegicus	119-125
20345607-6	2010	LysoPL2 mRNA was induced by zinc (Zn) and hydrogen peroxide (H(2)O(2)), and lysoPL2 knockout mutants showed enhanced sensitivity to Zn and H(2)O(2) in comparison to wild type.	Zinc	34-36	lysophospholipase 2	Arabidopsis thaliana	0-7
20345607-6	2010	LysoPL2 mRNA was induced by zinc (Zn) and hydrogen peroxide (H(2)O(2)), and lysoPL2 knockout mutants showed enhanced sensitivity to Zn and H(2)O(2) in comparison to wild type.	Zinc	132-134	lysophospholipase 2	Arabidopsis thaliana	76-83
21389531-4	2010	Bond order calculations show that Zn preference for the Ca2 vacancy, near the OH channel and with greater structural flexibility, is associated with the formation of a four-fold (bulk) and nearly four-fold (surface) coordination, as in ZnO.	Zinc	34-36	carbonic anhydrase 2	Homo sapiens	56-59
21389531-5	2010	When occupying the octahedral Ca1 vacancy, Zn remains six-fold in the bulk, but coordination decreases to five-fold in the surface.	Zinc	43-45	carbonic anhydrase 1	Homo sapiens	30-33
19937002-1	2010	A commercially available screen-printed carbon electrode coated with an ex situ deposited bismuth film (BiSPCE) has been applied to the determination of Pb(II) and Zn(II) ions in tap water (Barcelona water distribution network) by means of stripping voltammetry (SV) and stripping chronopotentiometry (SCP).	Zinc	164-170	nuclear RNA export factor 1	Homo sapiens	179-182
19862562-7	2010	Also, Fe in CA3 and dentate gyrus, Cu in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group.	Zinc	66-68	carbonic anhydrase 3	Rattus norvegicus	72-75
20689709-4	2010	Ga(O,O)(3) showed the highest anti-PAF activity but did not inhibit the thrombin-related pathway, whereas Zn(S,S)(2), with also a significant PAF inhibitory effect, exhibited the highest thrombin-related inhibition.	Zinc	106-113	prothrombin	Oryctolagus cuniculus	187-195
19655232-7	2010	We report here on two variants of a novel, bioactive, Al-free, Zn-based glass polyalkenoate cement (Zn-GPC), and how their properties compare to those of an injectable PMMA bone cement (SIMPL) that is widely used in VP and BKP.	Zinc	63-65	glycophorin C (Gerbich blood group)	Homo sapiens	103-106
19655232-7	2010	We report here on two variants of a novel, bioactive, Al-free, Zn-based glass polyalkenoate cement (Zn-GPC), and how their properties compare to those of an injectable PMMA bone cement (SIMPL) that is widely used in VP and BKP.	Zinc	100-102	glycophorin C (Gerbich blood group)	Homo sapiens	103-106
1567990-2	1992	This work employed fluorescence energy transfer techniques to measure the distance between the Zn2+ (Cu2+) site and the stronger Ca(2+)-binding site in parvalbumin.	Zinc	95-99	parvalbumin	Homo sapiens	152-163
1718728-7	1991	Treatment with the PTH agonist [Nle8,18,Tyr34]bovine PTH(1-34)NH2 [(NlePTH(1-34)] also markedly down-regulates PTH receptors in UMR 106 cells, but this effect is only partially inhibited in Zn(++)-induced UMR 4-7 cells.	Zinc	190-196	parathyroid hormone	Bos taurus	19-22
1718728-7	1991	Treatment with the PTH agonist [Nle8,18,Tyr34]bovine PTH(1-34)NH2 [(NlePTH(1-34)] also markedly down-regulates PTH receptors in UMR 106 cells, but this effect is only partially inhibited in Zn(++)-induced UMR 4-7 cells.	Zinc	190-196	parathyroid hormone	Bos taurus	53-56
1943730-5	1991	In a patient with Graves" disease whose plasma thyroxine (T4) and triiodothyronine (T3) concentrations changed remarkably because of poor compliance with the regimen, the change in plasma thyroid hormone levels preceded the change in the RBC CAI and Zn concentrations by 2 to 3 months.	Zinc	250-252	carbonic anhydrase 1	Homo sapiens	242-245
1657901-2	1991	In contrast to the p-NPP-ase part of the enzyme, the PPi-ase part requires Zn2+ as a cofactor for its hydrolytic activity.	Zinc	75-79	FKBP prolyl isomerase 2	Homo sapiens	53-60
1657901-3	1991	The PPi-ase activity of the enzyme can be inhibited by cadmium ions (Cd2+), perhaps by replacing Zn2+ from the active site of the enzyme molecule.	Zinc	97-101	FKBP prolyl isomerase 2	Homo sapiens	4-11
1657901-7	1991	Ascorbic acid may accordingly also remove Zn2+ from the active site of the PPi-ase.	Zinc	42-46	FKBP prolyl isomerase 2	Homo sapiens	75-82
1851092-6	1991	Addition of Zn2+ to reduced bc1 complex causes a red shift in the absorption spectrum of cytochrome b566 and a substantial decrease in the signal intensity of the EPR spectrum of the Fe-S protein.	Zinc	12-16	cytochrome b	Bos taurus	89-101
1826087-8	1991	Zn2+ ions are an inhibitor of C3b cleavage by factor I, a reaction in which factor H acts as a cofactor.	Zinc	0-4	complement C3	Homo sapiens	30-33
19883117-11	2009	Chimera HMA7/4n binds Cu(I) with an affinity between those of HMA4n and HMA7n but binds Zn(II) more weakly than either parent protein does.	Zinc	88-90	copper-exporting ATPase / responsive-to-antagonist 1 / copper-transporting ATPase (RAN1)	Arabidopsis thaliana	8-12
19877597-8	2009	A detailed investigation of the structure in aqueous solution of the complexes by using nuclear magnetic resonance (NMR) techniques and density functional theory (DFT) calculations (B3LYP) shows that while in the Zn(II) complex the metal ion is six-coordinated, in the Pb(II) and Ca(II) analogues the metal ions are eight-coordinated.	Zinc	213-219	carbonic anhydrase 2	Homo sapiens	280-286
1826087-8	1991	Zn2+ ions are an inhibitor of C3b cleavage by factor I, a reaction in which factor H acts as a cofactor.	Zinc	0-4	complement factor H	Homo sapiens	76-84
1826087-9	1991	Additions of Zn2+ to factor H caused it to form oligomers containing 4-10 monomers.	Zinc	13-17	complement factor H	Homo sapiens	21-29
1713274-6	1991	The effects of the chondroitinase were completely reversed by the addition of 1 mM Zn2+, a known inhibitor of this enzyme.	Zinc	83-87	galactosamine (N-acetyl)-6-sulfatase	Canis lupus familiaris	19-33
19501903-8	2009	These polypeptides were coordinated with the Zn(II) ions chelated to HAc chains for both the cross-linking of HAc and the tethering of BDNF.	Zinc	45-47	brain derived neurotrophic factor	Homo sapiens	135-139
19501903-10	2009	It was shown by release tests that the coordinated BDNF was firmly bound to the Zn(II)-chelated HAc for more than 12 days.	Zinc	80-86	brain derived neurotrophic factor	Homo sapiens	51-55
1977382-4	1990	The N-terminal sequence and amino acid composition of GP 130 showed that GP 130 is similar to rat kidney zinc peptidase and human intestinal aminopeptidase N. GP 130 had aminopeptidase N enzymic activity and was inhibited by bestatin (Ki = 36 microM), 1,10-phenanthroline (Ki 30 microM), Zn2+ (Ki 26 microM), Cu2+ (Ki 260 microM), pre-incubation with EDTA and by a polyclonal antibody against GP 130.	Zinc	288-292	alanyl aminopeptidase, membrane	Sus scrofa	54-60
1977382-4	1990	The N-terminal sequence and amino acid composition of GP 130 showed that GP 130 is similar to rat kidney zinc peptidase and human intestinal aminopeptidase N. GP 130 had aminopeptidase N enzymic activity and was inhibited by bestatin (Ki = 36 microM), 1,10-phenanthroline (Ki 30 microM), Zn2+ (Ki 26 microM), Cu2+ (Ki 260 microM), pre-incubation with EDTA and by a polyclonal antibody against GP 130.	Zinc	288-292	alanyl aminopeptidase, membrane	Sus scrofa	73-79
19637848-1	2009	We present three-pulse vibrational echo measurements of azide ion bound to the active site Zn of human carbonic anhydrase II (HCA II) and of two separate active-site mutants Thr199 --&gt; Ala (T199A) and Leu198 --&gt; Phe (L198F).	Zinc	91-93	carbonic anhydrase 2	Homo sapiens	103-124
1977382-4	1990	The N-terminal sequence and amino acid composition of GP 130 showed that GP 130 is similar to rat kidney zinc peptidase and human intestinal aminopeptidase N. GP 130 had aminopeptidase N enzymic activity and was inhibited by bestatin (Ki = 36 microM), 1,10-phenanthroline (Ki 30 microM), Zn2+ (Ki 26 microM), Cu2+ (Ki 260 microM), pre-incubation with EDTA and by a polyclonal antibody against GP 130.	Zinc	288-292	alanyl aminopeptidase, membrane	Sus scrofa	73-79
19630406-5	2009	Spectroscopic and X-ray crystallographic studies indicate that the sulfonate group within the stereogenic-at-Zn bidentate complexes coordinates syn to the proximal phenyl substituent of the NHC backbone (vs the initially expected anti).	Zinc	109-111	synemin	Homo sapiens	144-147
1977382-4	1990	The N-terminal sequence and amino acid composition of GP 130 showed that GP 130 is similar to rat kidney zinc peptidase and human intestinal aminopeptidase N. GP 130 had aminopeptidase N enzymic activity and was inhibited by bestatin (Ki = 36 microM), 1,10-phenanthroline (Ki 30 microM), Zn2+ (Ki 26 microM), Cu2+ (Ki 260 microM), pre-incubation with EDTA and by a polyclonal antibody against GP 130.	Zinc	288-292	alanyl aminopeptidase, membrane	Sus scrofa	73-79
1973646-6	1990	However, inhibitions by Zn2+ and Cu2+ were different between kidney and reproductive system GGT.	Zinc	24-28	gamma-glutamyltransferase 1	Homo sapiens	92-95
19809679-5	2009	Coordination of Asp 1 to Zn drives the complex towards the expulsion of one of initially bonded His side-chains.	Zinc	25-27	beta-secretase 2	Homo sapiens	16-21
32506408-6	2020	Fish exposed to Zn and fed SP showed high blood urea, catalase, ALT, AST, and total superoxide dismutase (T-SOD), while the malondialdehyde (MDA) was decreased (P < 0.05).	Zinc	16-18	catalase	Oreochromis niloticus	54-62
19622865-3	2009	In this structure, the Zn ion was shown to be pentacoordinated by His297, His301 and Glu320 of APN and the two O atoms of the phosphinic moiety of PL250.	Zinc	23-25	aminopeptidase N	Escherichia coli	95-98
19244162-10	2009	Zn(2+)-containing PS bound FXa more efficiently (K(d)(app)=9.3 nM) than Zn(2+)-deficient PS (K(d)(app)=110 nM).	Zinc	0-6	coagulation factor X	Homo sapiens	27-30
19416844-0	2009	Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.	Zinc	69-73	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	35-40
19416844-4	2009	We also show that CQ activates TRPA1 in a Zn(2+)-dependent manner.	Zinc	42-48	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
19416844-6	2009	Direct application of Zn(2+) to the intracellular face of excised, inside-out patches activates TRPA1 with an EC(50) value of 7.5 +/- 1 nM.	Zinc	22-24	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	96-101
19416844-9	2009	In conclusion, we have discovered that TRPA1 acts a sensor of intracellular Zn(2+), and that Zn(2+) ionophores, such as CQ and ZnPy, activate TRPA1 by increasing [Zn(2+)](i).	Zinc	76-78	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	39-44
19416844-9	2009	In conclusion, we have discovered that TRPA1 acts a sensor of intracellular Zn(2+), and that Zn(2+) ionophores, such as CQ and ZnPy, activate TRPA1 by increasing [Zn(2+)](i).	Zinc	76-78	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	142-147
19416844-9	2009	In conclusion, we have discovered that TRPA1 acts a sensor of intracellular Zn(2+), and that Zn(2+) ionophores, such as CQ and ZnPy, activate TRPA1 by increasing [Zn(2+)](i).	Zinc	93-95	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	142-147
19018666-0	2009	Modulation of redox switches of copper chaperone Cox17 by Zn(II) ions determined by new ESI MS-based approach.	Zinc	58-64	cytochrome c oxidase copper chaperone COX17	Homo sapiens	49-54
19018666-5	2009	We hypothesize that Zn(II) ions might protect cytosolic Cox17 from oxidation.	Zinc	20-26	cytochrome c oxidase copper chaperone COX17	Homo sapiens	56-61
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	105-110
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	72-74	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	105-110
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-6	2009	In order to get quantitative information about the modulatory effect of Zn(II) ions on redox switches in Cox17, we have used ESI MS for determination of the midpoint potentials for redox couples of Cox17: Cox17(3S-S) &lt;--&gt; Cox17(2S-S) (E(m1)) and Cox17(2S-S) &lt;--&gt; Cox17(0S-S) (E(m2)) in the presence of Zn(II).	Zinc	314-316	cytochrome c oxidase copper chaperone COX17	Homo sapiens	198-203
19018666-8	2009	Apparent dissociation constants for Zn(II) complexes of Cox17(0S-S) and Cox17(2S-S), are 0.067 and 0.29 nM, respectively.	Zinc	36-42	cytochrome c oxidase copper chaperone COX17	Homo sapiens	56-61
19018666-8	2009	Apparent dissociation constants for Zn(II) complexes of Cox17(0S-S) and Cox17(2S-S), are 0.067 and 0.29 nM, respectively.	Zinc	36-42	cytochrome c oxidase copper chaperone COX17	Homo sapiens	72-77
19018666-9	2009	The high affinity shows that metallation of Cox17(0S-S) by Zn(II) might be significant in cellular conditions, which might protect Cox17 from oxidation and enable its transport into IMS.	Zinc	59-65	cytochrome c oxidase copper chaperone COX17	Homo sapiens	44-49
18500671-4	2009	The mutation changes a conserved cysteine 39 to a glycine in the Zn(2+) site II of the RING domain, which is essential for BRCA1 ubiquitin ligase activity.	Zinc	65-67	BRCA1 DNA repair associated	Homo sapiens	123-128
19127548-5	2009	The roles that IDE/insulin concentration ratio, reaction time, adenosine 5"-triphosphate (ATP) and metal ions (Zn and Cu) have on the insulin cleavage pattern produced by IDE are investigated and a plausible interpretation involving the proteolytic action of the different IDE oligomeric forms is proposed.	Zinc	111-113	insulin degrading enzyme	Homo sapiens	171-174
19127548-5	2009	The roles that IDE/insulin concentration ratio, reaction time, adenosine 5"-triphosphate (ATP) and metal ions (Zn and Cu) have on the insulin cleavage pattern produced by IDE are investigated and a plausible interpretation involving the proteolytic action of the different IDE oligomeric forms is proposed.	Zinc	111-113	insulin degrading enzyme	Homo sapiens	171-174
20183605-1	2009	In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4") oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates.	Zinc	160-162	adenosine deaminase	Homo sapiens	53-72
20183605-1	2009	In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn(+2) coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4") oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates.	Zinc	160-162	adenosine deaminase	Homo sapiens	74-77
19402754-4	2009	We also show that S100A9 in the presence of Zn++ and Ca++ is an efficient ligand of receptor for advanced glycation end products (RAGE) and also an endogenous Toll ligand in that it shows a highly specific interaction with TLR4/MD2.	Zinc	44-48	S100 calcium binding protein A9	Homo sapiens	18-24
19402754-4	2009	We also show that S100A9 in the presence of Zn++ and Ca++ is an efficient ligand of receptor for advanced glycation end products (RAGE) and also an endogenous Toll ligand in that it shows a highly specific interaction with TLR4/MD2.	Zinc	44-48	advanced glycosylation end-product specific receptor	Homo sapiens	84-128
19402754-4	2009	We also show that S100A9 in the presence of Zn++ and Ca++ is an efficient ligand of receptor for advanced glycation end products (RAGE) and also an endogenous Toll ligand in that it shows a highly specific interaction with TLR4/MD2.	Zinc	44-48	advanced glycosylation end-product specific receptor	Homo sapiens	130-134
19348669-7	2009	It appeared that under conditions of Fe deficiency, the capacity for Zn uptake increased, most probably the result of low specificity of the Fe transporter IRT1 that was induced upon Fe deficiency.	Zinc	69-71	iron-regulated transporter 1	Arabidopsis thaliana	156-160
18951928-3	2009	Zn/PDTC treatment induces a strong apoptotic cell death that is associated to ROS-dependent nuclear translocation of the mitochondrial factor AIF, but not to the regulation of apoptotic genes and caspase activation.	Zinc	0-2	apoptosis inducing factor mitochondria associated 1	Homo sapiens	142-145
19763775-6	2009	Multiple alignments of protease peptides showed that the catalytic triads and binding residues for substrate, Zn2+ and the NS4 cofactor are conserved among different isolates, including ours, and confirmed the closer homology between NS3 of genotypes 4 and 1.	Zinc	110-114	KRAS proto-oncogene, GTPase	Homo sapiens	234-237
10354450-6	1999	These results indicate that specific interactions between the sulfonamide group on the inhibitor and the Zn(II) ion on CAII were preserved in the gas phase.	Zinc	105-111	carbonic anhydrase 2	Homo sapiens	119-123
18976665-6	2008	By ultracentrifugation, size-distribution analyses showed that monomeric FH at 5.57 S was the major species at [Zn] up to 60 microM.	Zinc	112-114	complement factor H	Homo sapiens	73-75
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	LIM zinc finger domain containing 1	Homo sapiens	131-137
19074270-3	2008	This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding.	Zinc	194-199	LIM zinc finger domain containing 1	Homo sapiens	219-225
34802936-3	2022	The results showed that Zn2+ and the probe formed (NIRF-Zn2+) complex after added Zn2+ into the probe NIRF solution, which emited red fluorescence.	Zinc	24-28	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	51-55
18688660-4	2008	The opposite relation was observed for the Cu level in the dentate gyrus and for Zn in the CA3 region of the hippocampus and in the dentate gyrus.	Zinc	81-83	carbonic anhydrase 3	Rattus norvegicus	91-94
34802936-3	2022	The results showed that Zn2+ and the probe formed (NIRF-Zn2+) complex after added Zn2+ into the probe NIRF solution, which emited red fluorescence.	Zinc	24-28	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	102-106
34802936-3	2022	The results showed that Zn2+ and the probe formed (NIRF-Zn2+) complex after added Zn2+ into the probe NIRF solution, which emited red fluorescence.	Zinc	82-86	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	51-55
34802936-3	2022	The results showed that Zn2+ and the probe formed (NIRF-Zn2+) complex after added Zn2+ into the probe NIRF solution, which emited red fluorescence.	Zinc	82-86	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	102-106
18606152-0	2008	3D local structure around Zn in Kti11p as a representative Zn-(Cys)4 motif as obtained by MXAN.	Zinc	26-28	diphthamide biosynthesis 3	Homo sapiens	32-38
34802936-4	2022	The probe can be used for quantitative detection of Zn2+ with a detection limit of 4.61 x 10-8 M. It was determined that the binding stoichiometry between the NIRF and Zn2+ was 1:1 according to the job,s curve.	Zinc	52-56	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	159-163
18606152-4	2008	Ab initio full MS calculations performed by MXAN are applied to obtain chemical and stereo structural information around the Zn ion in Kti11p.	Zinc	125-127	diphthamide biosynthesis 3	Homo sapiens	135-141
34802936-4	2022	The probe can be used for quantitative detection of Zn2+ with a detection limit of 4.61 x 10-8 M. It was determined that the binding stoichiometry between the NIRF and Zn2+ was 1:1 according to the job,s curve.	Zinc	168-172	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	159-163
18570882-0	2008	Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.	Zinc	79-83	DExD-box helicase 21	Homo sapiens	17-20
34802936-5	2022	Subsequently, CN- was added to the NIRF-Zn2+ solution, CN- combined with Zn2+ to generate (Zn(CN-)x)1-x due to the stronger binding ability between zinc ion and cyanogen, which lead to the red fluorescence disappeared.	Zinc	73-77	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	35-39
18570882-0	2008	Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.	Zinc	79-83	DExD-box helicase 21	Homo sapiens	32-35
34802936-9	2022	In addition, the probe NIRF has good applicability for Zn2+ and CN- detection in actual samples.	Zinc	55-59	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	23-27
18570882-0	2008	Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.	Zinc	79-83	DExD-box helicase 21	Homo sapiens	32-35
34857349-8	2022	In the end, the applicability of the developed approach was successfully evaluated to determine Zn2+ in tap, mineral, and river water samples.	Zinc	96-100	nuclear RNA export factor 1	Homo sapiens	104-107
18570882-5	2008	In this study, we determined the potency of Zn(2+)-cyclen-PAGE for the detection of the Gua/Cyt-to-Cyt/Gua single substitutions in some artificial Gua/Cyt-lined sequences derived from a human cardiac sodium channel gene, SCN5A.	Zinc	44-46	DExD-box helicase 21	Homo sapiens	88-91
18570882-5	2008	In this study, we determined the potency of Zn(2+)-cyclen-PAGE for the detection of the Gua/Cyt-to-Cyt/Gua single substitutions in some artificial Gua/Cyt-lined sequences derived from a human cardiac sodium channel gene, SCN5A.	Zinc	44-46	DExD-box helicase 21	Homo sapiens	103-106
18570882-5	2008	In this study, we determined the potency of Zn(2+)-cyclen-PAGE for the detection of the Gua/Cyt-to-Cyt/Gua single substitutions in some artificial Gua/Cyt-lined sequences derived from a human cardiac sodium channel gene, SCN5A.	Zinc	44-46	DExD-box helicase 21	Homo sapiens	103-106
18574758-6	2008	Terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL) staining showed that exposure to 100microM Zn(2+) significantly increased the number of pro-apoptotic neurons in cultures maintained with BDNF, while these conditions had no effect on cultures maintained with CNTF.	Zinc	134-136	brain-derived neurotrophic factor	Rattus norvegicus	229-233
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	135-137	brain-derived neurotrophic factor	Rattus norvegicus	25-29
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	135-137	brain-derived neurotrophic factor	Rattus norvegicus	99-103
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	135-137	brain-derived neurotrophic factor	Rattus norvegicus	99-103
34922149-4	2022	The NTPase of the DHAV-1 2C protein is Mg2+ indispensable and affected by other biochemical characteristics such as Mn2+, Ca2+, Zn2+, Na+ and pH.	Zinc	128-132	inosine triphosphatase	Homo sapiens	4-10
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	161-163	brain-derived neurotrophic factor	Rattus norvegicus	25-29
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	161-163	brain-derived neurotrophic factor	Rattus norvegicus	99-103
34964348-9	2021	Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL.	Zinc	33-35	neurofilament light chain	Homo sapiens	130-133
18574758-7	2008	We also demonstrate that BDNF protomer cross-linking efficiency and TrkB receptor cross-linking to BDNF are significantly inhibited by Zn(2+), suggesting that a Zn(2+)-induced change in BDNF conformation inhibits receptor-binding activity.	Zinc	161-163	brain-derived neurotrophic factor	Rattus norvegicus	99-103
34944467-5	2021	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	55-59	carbonic anhydrase 2	Homo sapiens	46-49
18452312-1	2008	Matrix metalloproteases (MMPs) are Zn-containing endopeptidases involved in the degradation of extracellular matrix components and are typically secreted in a latent (pro-MMP) form and activated either by proteolytic or oxidative disruption of a conserved cysteine switch.	Zinc	35-37	matrix metallopeptidase 9	Homo sapiens	25-29
18452312-5	2008	In fact, high concentrations of DETA-NO were found to inhibit MMP-9 activity, presumably by direct interaction with the active-site Zn (2+).	Zinc	132-134	matrix metallopeptidase 9	Homo sapiens	62-67
34944467-5	2021	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	106-110	carbonic anhydrase 2	Homo sapiens	46-49
34944467-6	2021	In addition, two lower affinity sites can bind Zn2+ even when the EF-hands are saturated by Ca2+, resulting in a 2Ca2+:S100A1:2Zn2+ conformer.	Zinc	47-51	carbonic anhydrase 2	Homo sapiens	92-95
34944467-8	2021	We also determined a higher affinity to Ca2+ (KD~0.16 and 24 mum) than was previously reported for S100A1, which would allow this protein to function as a Ca2+/Zn2+-sensor both inside and outside cells, participating in diverse signaling pathways under normal and pathological conditions.	Zinc	160-164	carbonic anhydrase 2	Homo sapiens	40-43
34944467-8	2021	We also determined a higher affinity to Ca2+ (KD~0.16 and 24 mum) than was previously reported for S100A1, which would allow this protein to function as a Ca2+/Zn2+-sensor both inside and outside cells, participating in diverse signaling pathways under normal and pathological conditions.	Zinc	160-164	carbonic anhydrase 2	Homo sapiens	155-158
34655964-8	2021	The calculated addition of Zn is given as median (p25 - p75).	Zinc	27-29	tubulin polymerization promoting protein	Homo sapiens	50-53
18433093-2	2008	We present here simulated magnetic circular dichroism (MCD) spectra of MTAP (M=Mg, Ni, Zn) and MPc (M=Mg, Zn) where TAP=tetraazaporphyrin and Pc=phthalocyanine.	Zinc	87-89	methylthioadenosine phosphorylase	Homo sapiens	71-75
34766907-2	2021	TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn2+, Mg2+ and Ca2+, and thus shapes cellular excitability, plasticity and metabolic activity.	Zinc	82-86	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-5
18222915-7	2008	Significant correlations were also found in seminal plasma between MSP and prostate-specific antigen (PSA) (r = .65, P &lt; .001) and between MSP and Zn(2+) (r = .54, P &lt; .001).	Zinc	150-152	microseminoprotein beta	Homo sapiens	142-145
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Zinc	37-42	heat shock protein family D (Hsp60) member 1	Homo sapiens	116-121
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Zinc	37-42	heat shock protein family D (Hsp60) member 1	Homo sapiens	123-131
18368618-5	2008	Zn and Cu were detected at high levels in water-soluble fractions (TP2 &gt; TP1).	Zinc	0-2	transition protein 1	Rattus norvegicus	76-79
18368618-12	2008	The observed acute pulmonary toxicity of TP could be due to the presence of water soluble Zn and Cu.	Zinc	90-92	transition protein 2	Rattus norvegicus	41-43
18074158-2	2008	Since, basically, the Zn(II) stability constants of only two cytosolic zinc enzymes, carbonic anhydrase and superoxide dismutase, have been reported, the affinity for Zn(II) of another zinc enzyme, sorbitol dehydrogenase (SDH), was determined.	Zinc	167-169	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	222-225
17671992-6	2007	The NMDA (10 microM) response was blocked by 1 nM Zn(2+) and 1 microM ifenprodil, compatible with the involvement of a NR1/NR2A/NR2B assembly, although the presence of two separate receptor populations, i.e., NR1/NR2A and NR1/NR2B, cannot be excluded.	Zinc	50-52	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	128-132
17672825-3	2007	Mammalian Cox17 exists in three oxidative states, each characterized by distinct metal-binding properties: fully reduced mammalian Cox17(0S-S) binds co-operatively to four Cu+; Cox17(2S-S), with two disulfide bridges, binds to one of either Cu+ or Zn2+; and Cox17(3S-S), with three disulfide bridges, does not bind to any metal ions.	Zinc	248-252	cytochrome c oxidase copper chaperone COX17	Homo sapiens	10-15
17672825-3	2007	Mammalian Cox17 exists in three oxidative states, each characterized by distinct metal-binding properties: fully reduced mammalian Cox17(0S-S) binds co-operatively to four Cu+; Cox17(2S-S), with two disulfide bridges, binds to one of either Cu+ or Zn2+; and Cox17(3S-S), with three disulfide bridges, does not bind to any metal ions.	Zinc	248-252	cytochrome c oxidase copper chaperone COX17	Homo sapiens	131-136
17672825-3	2007	Mammalian Cox17 exists in three oxidative states, each characterized by distinct metal-binding properties: fully reduced mammalian Cox17(0S-S) binds co-operatively to four Cu+; Cox17(2S-S), with two disulfide bridges, binds to one of either Cu+ or Zn2+; and Cox17(3S-S), with three disulfide bridges, does not bind to any metal ions.	Zinc	248-252	cytochrome c oxidase copper chaperone COX17	Homo sapiens	131-136
17672825-3	2007	Mammalian Cox17 exists in three oxidative states, each characterized by distinct metal-binding properties: fully reduced mammalian Cox17(0S-S) binds co-operatively to four Cu+; Cox17(2S-S), with two disulfide bridges, binds to one of either Cu+ or Zn2+; and Cox17(3S-S), with three disulfide bridges, does not bind to any metal ions.	Zinc	248-252	cytochrome c oxidase copper chaperone COX17	Homo sapiens	131-136
17848574-8	2007	MDM2 in which one of the Zn(2+) coordinating residues is mutated (C478S or C464A) blocks degradation but enhances folding of p53.	Zinc	25-27	MDM2 proto-oncogene	Homo sapiens	0-4
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Zinc	130-134	transient receptor potential cation channel subfamily M member 6	Homo sapiens	38-43
17098283-4	2007	Neutralization of E1029 (conserved in TRPM6, TRPM7, TRPM4 and TRPM5) resulted in channels with increased conductance for Ba2+ and Zn2+, decreased ruthenium red sensitivity and larger pore diameter compared to wild-type TRPM6.	Zinc	130-134	transient receptor potential cation channel subfamily M member 7	Homo sapiens	45-50
17331952-2	2007	Here, we investigated the redox regulation at the Zn(2+) binding site (HX(5)CX(20)CC) in the intracellular T1-T1 inter-subunit interface of a Kv4 channel.	Zinc	50-56	potassium voltage-gated channel subfamily C member 1	Homo sapiens	142-145
17331952-8	2007	We propose that the interfacial T1 Zn(2+) site of Kv4 channels acts as a Zn(2+)-dependent redox switch that may regulate the activity of neuronal and cardiac A-type K(+) currents under physiological and pathological conditions.	Zinc	35-41	potassium voltage-gated channel subfamily C member 1	Homo sapiens	50-53
17624187-5	2007	Zn-supplement increased the CD4+/CD3+ cell percentage, and simultaneously decreased the CD8+/CD3+ cell population.	Zinc	0-2	CD8a molecule	Homo sapiens	88-91
17086401-4	2007	Transgenic plants with moderate AtPCS1 expression levels showed significantly higher tolerance to Cd and Zn stress, but accumulated significantly less Cd and Zn than wild type plants in both shoot and root tissues.	Zinc	105-107	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	32-38
17086401-4	2007	Transgenic plants with moderate AtPCS1 expression levels showed significantly higher tolerance to Cd and Zn stress, but accumulated significantly less Cd and Zn than wild type plants in both shoot and root tissues.	Zinc	158-160	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	32-38
17625247-4	2007	MsrB is a selenoprotein reported to contain zinc (Zn).	Zinc	50-52	methionine sulfoxide reductase B2	Mus musculus	0-4
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	66-70	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	30-43
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	66-70	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	181-194
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	218-222	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	30-43
17008051-8	2007	Pharmacological inhibition of IKKalpha/beta activity reduced both Zn2+-induced p65/RelA phosphorylation at Ser 536 and NF-kappaB-dependent transcriptional activity, suggesting that IKKalpha/beta is necessary for these Zn2+-induced effects.	Zinc	218-222	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	181-194
17289437-2	2007	Liver catalase (CAT) activity was influenced by Cd and Pb exposures, while it was inhibited by Zn exposure.	Zinc	95-97	catalase	Oreochromis niloticus	6-14
17289437-2	2007	Liver catalase (CAT) activity was influenced by Cd and Pb exposures, while it was inhibited by Zn exposure.	Zinc	95-97	catalase	Oreochromis niloticus	16-19
17020885-7	2006	We analyzed APOBEC3 proteins in which either the critical glutamic acid residue or the Zn(2+) coordination amino acid residues in the active sites were mutated.	Zinc	87-89	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	Mus musculus	12-19
17093223-4	2006	In pancreatic tissue, the activity of amylase, carboxypeptidase A, chymotrypsin, trypsin, and lipase increased (P &lt; 0.01) in pigs fed 2,500 ppm of Zn, whereas the activity of carboxypeptidase B and carboxylester hydrolase was unaffected.	Zinc	150-152	carboxypeptidase B1	Sus scrofa	178-196
17093223-12	2006	In pigs fed 100 ppm of Zn, the activity of aminopeptidase N was greater in the caudal small intestine, but dietary Zn or Cu had no effect on aminopeptidase N in the cranial and middle small intestine.	Zinc	23-25	alanyl aminopeptidase, membrane	Sus scrofa	43-59
17015178-8	2006	Immunoblot analyses, which suggested GSH interacts with MMP-9"s active-site Zn, were corroborated by computational molecular modeling.	Zinc	76-78	matrix metallopeptidase 9	Homo sapiens	56-61
34791819-0	2021	Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.	Zinc	0-2	bone marrow stromal cell antigen 2	Homo sapiens	53-57
19754813-5	2006	Sequence differences between individuals in p53 and SIRT2 were found in two cell lines including a stop codon in p53 and substitutions of conserved cysteine residues in the Zn(2+)-binding motif in SIRT2.	Zinc	173-175	sirtuin 2	Canis lupus familiaris	52-57
19754813-5	2006	Sequence differences between individuals in p53 and SIRT2 were found in two cell lines including a stop codon in p53 and substitutions of conserved cysteine residues in the Zn(2+)-binding motif in SIRT2.	Zinc	173-175	sirtuin 2	Canis lupus familiaris	197-202
34791819-0	2021	Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.	Zinc	0-2	bone marrow stromal cell antigen 2	Homo sapiens	58-66
34791819-1	2021	We present in this work a first X-ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS-CoV-2 orf7a proteins as well as with some of their complexes.	Zinc	91-93	bone marrow stromal cell antigen 2	Homo sapiens	105-109
34791819-1	2021	We present in this work a first X-ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS-CoV-2 orf7a proteins as well as with some of their complexes.	Zinc	91-93	bone marrow stromal cell antigen 2	Homo sapiens	110-118
34627839-11	2021	Together, our data indicate that TRPM7 regulates cellular levels of MDMX in part by modulating the intracellular Zn2+ concentration to promote tumorigenesis.	Zinc	113-117	transient receptor potential cation channel subfamily M member 7	Homo sapiens	33-38
16878961-7	2006	The ZAP1-3 probes can detect Zn2+ fluorimetrically at pH 9, indicating that proton-induced background emission obscures any Zn2+-induced fluorescence at pH 7.	Zinc	29-33	zinc finger protein 569	Homo sapiens	4-10
34591459-5	2021	By characterizing TdT nucleotide selectivity under different conditions, we show that TdT can encode various physiologically relevant signals such as Co2+, Ca2+, and Zn2+ concentrations and temperature changes in vitro.	Zinc	166-170	DNA nucleotidylexotransferase	Homo sapiens	18-21
16878961-7	2006	The ZAP1-3 probes can detect Zn2+ fluorimetrically at pH 9, indicating that proton-induced background emission obscures any Zn2+-induced fluorescence at pH 7.	Zinc	124-128	zinc finger protein 569	Homo sapiens	4-10
16878961-8	2006	The tertiary amine groups in ZAP1-3 are less basic than those in ZP1, which implies that the additional pyridine rings are responsible for the emissive response to Zn2+ at pH 7.0.	Zinc	164-168	zinc finger protein 569	Homo sapiens	29-33
16813414-0	2006	Model peptides based on the binding loop of the copper metallochaperone Atx1: selectivity of the consensus sequence MxCxxC for metal ions Hg(II), Cu(I), Cd(II), Pb(II), and Zn(II).	Zinc	173-175	antioxidant 1 copper chaperone	Homo sapiens	72-76
16410015-9	2006	These data show that Zn2+-induced activation of EGFR in HAEC involves a loss of PTP activities whose function is to dephosphorylate EGFR in opposition to baseline EGFR kinase activity.	Zinc	21-25	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	80-83
16633561-4	2006	Both AtCAD5 and AtCAD4 are dimers with two zinc ions per subunit and belong to the Zn-dependent medium chain dehydrogenase/reductase (MDR) superfamily, on the basis of their overall 2-domain structures and distribution of secondary structural elements.	Zinc	83-85	cinnamyl alcohol dehydrogenase 5	Arabidopsis thaliana	5-11
16633561-6	2006	Using AtCAD5, site-directed mutagenesis of Glu70 to alanine resulted in loss of catalytic activity, thereby indicating that perturbation of the Zn2+ coordination was sufficient to abolish catalytic activity.	Zinc	144-148	cinnamyl alcohol dehydrogenase 5	Arabidopsis thaliana	6-12
16602764-0	2006	Ratiometric Zn2+ sensor and strategy for Hg2+ selective recognition by central metal ion replacement.	Zinc	12-16	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	41-44
16533897-13	2006	These observations strongly suggest that Kv4 channel gating is tightly coupled to voltage-dependent accessibility changes of native T1 cysteines in the intersubunit Zn(2+) site.	Zinc	165-167	potassium voltage-gated channel subfamily C member 1	Homo sapiens	41-44
16432573-1	2006	The apparently paradoxical behaviour of facile exchange (kinetic lability) of tightly bound (thermodynamic stability) zinc ions in the enzyme IMP-1 metallo-beta-lactamase with Zn-68 and cadmium ions, as indicated by in-torch vaporization inductively-coupled plasma mass spectrometry (ITV-ICP-MS) and electrospray-ionization mass spectrometry (ESI-MS), is consistent with the involvement of a third metal ion in promoting Lewis acid/base type exchange processes.	Zinc	176-178	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	142-147
16330358-9	2005	Also, metallothionein 1 genes (MT1F, MT1G, MT1K) were up-regulated by Zn only.	Zinc	70-72	metallothionein 1F	Homo sapiens	31-35
16094687-6	2005	Typically, a disaccharide--Hin beta(1,2)Man alphaMe--was difficult to bend under all the tested reaction conditions, and the bent population in the presence of Zn(II) was only 4%.	Zinc	160-162	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	31-39
16094687-7	2005	On the other hand, a trisaccharide--Man alpha(1,3)Hin beta(1,2)Man alphaMe--was bent immediately after the addition of Zn(II) or Hg(II), and the bent population reached 75%, much larger than those of all the other hinged trisaccharides ever tested (&lt;40%).	Zinc	119-121	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	54-62
16245854-6	2005	On dissolution in SLF, the most limiting metals were Pb, Cu, and Zn.	Zinc	65-67	slf	Drosophila melanogaster	18-21
16002443-3	2005	In ClC-1, however, previous results suggested that Zn2+ block is independent of gating, and that the cysteine residues involved in Zn2+ binding are in different positions to those that confer Zn2+ sensitivity on ClC-0.	Zinc	51-55	chloride voltage-gated channel 1	Homo sapiens	3-8
16002443-3	2005	In ClC-1, however, previous results suggested that Zn2+ block is independent of gating, and that the cysteine residues involved in Zn2+ binding are in different positions to those that confer Zn2+ sensitivity on ClC-0.	Zinc	131-135	chloride voltage-gated channel 1	Homo sapiens	3-8
16002443-3	2005	In ClC-1, however, previous results suggested that Zn2+ block is independent of gating, and that the cysteine residues involved in Zn2+ binding are in different positions to those that confer Zn2+ sensitivity on ClC-0.	Zinc	131-135	chloride voltage-gated channel 1	Homo sapiens	3-8
16002443-4	2005	In this work, we show that Zn2+ block of ClC-1 is faster at hyperpolarized potentials where the channel is more likely to be in the closed state.	Zinc	27-31	chloride voltage-gated channel 1	Homo sapiens	41-46
16002443-5	2005	Mutation C277S, equivalent to C212S in ClC-0, which locks the common gate in ClC-1 open, virtually eliminates Zn2+ block.	Zinc	110-114	chloride voltage-gated channel 1	Homo sapiens	77-82
16002443-9	2005	The Q10 of approximately 13 of the time course of Zn2+ block, which is significantly higher than the Q10 of common gating transitions in WT ClC-1, suggests that Zn2+ binds to a very high temperature-dependent low-probability closed substate of the common gate, which has not yet been characterized in this channel.	Zinc	50-54	chloride voltage-gated channel 1	Homo sapiens	140-145
16002443-9	2005	The Q10 of approximately 13 of the time course of Zn2+ block, which is significantly higher than the Q10 of common gating transitions in WT ClC-1, suggests that Zn2+ binds to a very high temperature-dependent low-probability closed substate of the common gate, which has not yet been characterized in this channel.	Zinc	161-165	chloride voltage-gated channel 1	Homo sapiens	140-145
16355814-9	2005	CONCLUSION: From the results of our study, it can be hypothesized that serum Zn levels should be closely monitored during the course of DM1 and supplementation may be given to patients, especially at the time of puberty.	Zinc	77-79	DM1 protein kinase	Homo sapiens	136-139
16215279-3	2005	A key step in this selective neuronal injury is Ca2+/Zn2+ entry into vulnerable neurons through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor channels, a principle subtype of glutamate receptors.	Zinc	53-57	carbonic anhydrase 2	Homo sapiens	48-51
16215279-5	2005	Circumstance data have indicated that the GluR2 subunits dictate Ca2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons.	Zinc	70-74	carbonic anhydrase 2	Homo sapiens	65-68
16215279-5	2005	Circumstance data have indicated that the GluR2 subunits dictate Ca2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons.	Zinc	70-74	carbonic anhydrase 2	Homo sapiens	133-136
15964842-0	2005	Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.	Zinc	28-32	tripartite motif containing 17	Homo sapiens	130-134
15964842-8	2005	The linker region between the RING and B-box motifs is crucial for full folding, and Zn2+ affinity of the RING-B-box region is further protected in the entire RBCC region and appears to interact with the coiled-coil region.	Zinc	85-89	tripartite motif containing 17	Homo sapiens	159-163
16853177-8	2005	The possible growth mechanism of the composite nanowires may be enucleated that Zn atoms in the source vapor will replace the Sn atoms on the surface of the formed SnO(2) nanowires due to the higher reducibility of Zn than Sn.	Zinc	80-82	strawberry notch homolog 2	Homo sapiens	164-167
16853177-8	2005	The possible growth mechanism of the composite nanowires may be enucleated that Zn atoms in the source vapor will replace the Sn atoms on the surface of the formed SnO(2) nanowires due to the higher reducibility of Zn than Sn.	Zinc	215-217	strawberry notch homolog 2	Homo sapiens	164-167
16142921-2	2005	The insertion of Ni(II) into the precursor enzyme follows the incorporation of the iron center and is the function of HypA, a Zn(II)-binding protein, and HypB, a GTPase.	Zinc	126-129	hypA	Escherichia coli	118-122
15985434-1	2005	Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+.	Zinc	124-128	pyridoxal kinase	Homo sapiens	0-16
15985434-1	2005	Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+.	Zinc	124-128	pyridoxal kinase	Homo sapiens	18-22
15984002-3	2005	By comparing parallel tissue series histologically reacted for Zn and parvalbumin (PV), we further found that regions high in Zn are typically low in PV neuropil.	Zinc	126-128	parvalbumin	Homo sapiens	70-81
15984002-3	2005	By comparing parallel tissue series histologically reacted for Zn and parvalbumin (PV), we further found that regions high in Zn are typically low in PV neuropil.	Zinc	126-128	parvalbumin	Homo sapiens	83-85
34591459-5	2021	By characterizing TdT nucleotide selectivity under different conditions, we show that TdT can encode various physiologically relevant signals such as Co2+, Ca2+, and Zn2+ concentrations and temperature changes in vitro.	Zinc	166-170	DNA nucleotidylexotransferase	Homo sapiens	86-89
34630544-1	2021	Dihydroorotase (DHOase) possesses a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine.	Zinc	72-74	dihydroorotase	Saccharomyces cerevisiae S288C	0-14
15984002-3	2005	By comparing parallel tissue series histologically reacted for Zn and parvalbumin (PV), we further found that regions high in Zn are typically low in PV neuropil.	Zinc	126-128	parvalbumin	Homo sapiens	150-152
16045754-8	2005	Quantitative evaluation of the regulatory effects of divalent metal cations on the l-T3-sulfating activity of SULT1 ST5 revealed that Fe2+, Hg2+, Co2+, Zn2+, Cu2+, Cd2+ and Pb2+ exhibited dramatic inhibitory effects, whereas Mn2+ showed a significant stimulation.	Zinc	152-156	sulfotransferase family 1, cytosolic sulfotransferase 5	Danio rerio	110-119
34630544-1	2021	Dihydroorotase (DHOase) possesses a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine.	Zinc	72-74	dihydroorotase	Saccharomyces cerevisiae S288C	16-22
34901539-8	2022	Whereas the direct stimulating effects on BMSCs by Zn2+/Sr2+ were more effectively at the later stage with Nfatc1/Maf and Wnt signals activated.	Zinc	51-55	nuclear factor of activated T cells 1	Homo sapiens	107-113
16240177-8	2005	The MT1 knockdown plant lines were all hypersensitive to Cd and accumulated several fold lower levels of As, Cd, and Zn than wildtype, while Cu and Fe levels were unaffected.	Zinc	117-119	metallothionein 1A	Arabidopsis thaliana	4-7
15995183-4	2005	Metal analysis was used to demonstrate that HypA simultaneously binds stoichiometric Zn(2+) and stoichiometric Ni(2+).	Zinc	85-87	hypA	Escherichia coli	44-48
34174323-6	2021	On the contrary, BBR and/or Zn produced marked protection against MTX-induced intestinal toxicity via amelioration of oxidative stress, improving NRF2, SIRT1, FOXO-3, GSK-3beta, Akt, mTOR, JAK1, and STAT-3 alterations.	Zinc	28-30	mechanistic target of rapamycin kinase	Rattus norvegicus	183-187
34399895-1	2021	A rationally designed multifunctional polydopamine (PDA)-coated metal-organic frameworks (MOFs) biosensors for detection of miRNA-122 with Zn2+-triggered aggregation-induced enhancement (AIE) and synergistic chem-photothermal therapy in vitro was developed for the first time.	Zinc	139-143	microRNA 122	Homo sapiens	124-133
15788415-4	2005	The IMP-1 mutants exhibited 10(2)-10(4)-fold drops in k(cat) values compared with WT despite the fact that they contained two Zn(II) ions in the active site.	Zinc	126-128	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	4-9
34399895-3	2021	The pH-responsive MOFs structure was decomposed under the influence of acidic environment, and a large amount of free Zn2+ was released as the trigger agent for AIE signal amplification, realizing the ultra-sensitive detection of miRNA-122 and the accurate discrimination of the cells with different expression levels of miRNA-122, with the detection limit as low as 12.5 pM.	Zinc	118-122	microRNA 122	Homo sapiens	230-239
34399895-3	2021	The pH-responsive MOFs structure was decomposed under the influence of acidic environment, and a large amount of free Zn2+ was released as the trigger agent for AIE signal amplification, realizing the ultra-sensitive detection of miRNA-122 and the accurate discrimination of the cells with different expression levels of miRNA-122, with the detection limit as low as 12.5 pM.	Zinc	118-122	microRNA 122	Homo sapiens	321-330
15698955-4	2005	Results demonstrate that MT-3 binds Zn2+ and Cd2+ ions more weakly than MT-2 but exposes higher metal-binding capacity and plasticity.	Zinc	36-40	metallothionein 3	Homo sapiens	25-29
34401540-14	2021	However, Zn supplementation increased (P < 0.05) copper zinc superoxide dismutase (CuZnSOD) activity and metallothionein mRNA expression, and effectively decreased (P < 0.05) the expressions of HSP70 mRNA and protein, as well as HSP90 mRNA.	Zinc	9-11	heat shock protein family A (Hsp70) member 4	Homo sapiens	194-199
34382330-0	2021	Red Bean Pod Derived Heterostructure Carbon Decorated with Hollow Mixed Transition Metals as a Bifunctional Catalyst in Zn-Air Batteries.	Zinc	120-122	brain expressed associated with NEDD4 1	Homo sapiens	4-8
15664358-5	2005	The purity of IgG(1) in the eluate fractions was high when eluted from Zn(2+) complex.	Zinc	71-73	LOC105243590	Mus musculus	14-20
34505134-13	2021	Results indicate that Cu and Zn from HTM have low solubility in the rumen and appear to be less tightly bound to ruminal solid digesta than Cu and Zn from STM.	Zinc	147-149	sulfotransferase family 1A member 3	Homo sapiens	155-158
15713062-4	2005	Results show that Zn2+ occupies an octahedral site in the interior of the OT peptide that frees the N-terminus and creates a structured hydrophobic binding site on the peptide exterior; both factors are conducive to binding oxytocin to its receptor.	Zinc	18-22	oxytocin/neurophysin I prepropeptide	Homo sapiens	224-232
15701702-2	2005	Its affinity for CXCR4 is enhanced by binding to Cu2+, Ni2+, or Zn2+.	Zinc	64-68	C-X-C motif chemokine receptor 4	Homo sapiens	17-22
34667575-4	2021	Screening the HTC-PhABit library with carbonic anhydrase I (CAI) afforded 7 hits (0.7% hit rate), which were found to covalently crosslink in the Zn2+ binding pocket.	Zinc	146-150	carbonic anhydrase 1	Homo sapiens	38-58
15670982-1	2005	OBJECTIVE: This study was carried out to evaluate the effect of short-chain fructooligosaccharides (sc-FOS) on the absorption of Cu, Zn, and Se among postmenopausal women who are potential candidates to subclinical trace element deficiencies.	Zinc	133-135	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-106
34667575-4	2021	Screening the HTC-PhABit library with carbonic anhydrase I (CAI) afforded 7 hits (0.7% hit rate), which were found to covalently crosslink in the Zn2+ binding pocket.	Zinc	146-150	carbonic anhydrase 1	Homo sapiens	60-63
34439491-1	2021	TRPM2 channels admit Ca2+ and Na+ across the plasma membrane and release Ca2+ and Zn2+ from lysosomes.	Zinc	82-86	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
15621272-0	2005	Disturbances on delta aminolevulinate dehydratase (ALA-D) enzyme activity by Pb2+, Cd2+, Cu2+, Mg2+, Zn2+, Na+, K+ and Li+: analysis based on coordination geometry and acid-base Lewis capacity.	Zinc	101-105	aminolevulinate dehydratase	Gallus gallus	51-56
34112355-6	2021	Zn2+ was shown to possess adipotropic effects through the role of zinc transporters, zinc finger proteins, and Zn-alpha2-glycoprotein in adipose tissue physiology, underlying its particular role in pathogenesis of obesity and diabetes mellitus type 2.	Zinc	0-4	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	111-133
35460952-10	2022	These associations were mainly driven by Cu and Sb for mPC1; Se, Zn and Cd for mPC2; Co, Se and Zn for mPC3; and Zn for mPC4.	Zinc	113-115	proprotein convertase subtilisin/kexin type 4	Mus musculus	120-124
35623885-6	2022	Blockade of the primary route for Zn2+ entry, the mitochondrial Ca2+ uniporter (MCU; with ruthenium red, RR) or Zn2+ chelation shortly after OGD withdrawal substantially attenuated the mitochondrial depolarization and the changes in synaptic activity.	Zinc	34-38	mitochondrial calcium uniporter	Rattus norvegicus	80-83
35584675-3	2022	Here, we present evidence for a conserved family of putative metal transferases in human and fungi, which interact with Zn-dependent methionine aminopeptidase type I (MetAP1/Map1p/Fma1).	Zinc	120-122	methionyl aminopeptidase 1	Homo sapiens	167-173
15657441-5	2005	Using mutagenesis, we identified a putative zinc (Zn) binding domain within Ubp8 as being critical for the association with SAGA.	Zinc	50-52	ubiquitin-specific protease UBP8	Saccharomyces cerevisiae S288C	76-80
35584675-3	2022	Here, we present evidence for a conserved family of putative metal transferases in human and fungi, which interact with Zn-dependent methionine aminopeptidase type I (MetAP1/Map1p/Fma1).	Zinc	120-122	methionyl aminopeptidase 1	Homo sapiens	174-179
15657441-6	2005	The Zn binding domain is required for H2B deubiquitylation and for growth on media requiring Ubp8"s function in gene activation.	Zinc	4-6	ubiquitin-specific protease UBP8	Saccharomyces cerevisiae S288C	93-97
35075596-7	2022	The stimulation of TRPM2 induced the increase of TRPM2 current densities, lipid peroxidation, cytosolic ROS, miROS, cytosolic Ca2+, and Zn2+ values in the Hep2 cells after the treatment of PAX, although their values were decreased by the treatment of MLT and TRPM2 antagonists (ACA and 2APB).	Zinc	136-140	transient receptor potential cation channel subfamily M member 2	Homo sapiens	19-24
15759501-4	2005	At the equimolar Zn2+ concentration, zinc ions form a stable complex with His119(GH1).	Zinc	17-21	somatotropin	Sus scrofa	81-84
15620738-1	2005	Six 5 wt.% metal sorbents including Mn, Fe, Cu, Co, Ce and Zn supported on gamma-Al2O3, prepared by the incipient wetness impregnation method with calcination at 700 degrees C for 2 h, have been investigated for sorption of hydrogen sulfide in the temperature range of 500-700 degrees C. The sorption experiments were conducted in a fixed-bed reactor in terms of breakthrough curves and characterized by X-ray powder diffraction.	Zinc	59-61	SIX homeobox 5	Homo sapiens	0-5
19641676-4	2005	Reactive oxygen species act directly on PKC, releasing chelated Zn(2+) ions from the zinc finger of the regulatory domain.	Zinc	64-70	protein kinase C, gamma	Rattus norvegicus	40-43
19641676-5	2005	Zn(2+) release from PKC by oxidative stress has been shown at the level of isolated protein fragments, PKC immune complexes and single cells.	Zinc	0-6	protein kinase C, gamma	Rattus norvegicus	20-23
19641676-5	2005	Zn(2+) release from PKC by oxidative stress has been shown at the level of isolated protein fragments, PKC immune complexes and single cells.	Zinc	0-6	protein kinase C, gamma	Rattus norvegicus	103-106
19641676-8	2005	The studies lead to an unexpected and intriguing result, suggesting that in addition to serving a structural function, Zn(2+) ions are likely to play a dynamic regulatory role in PKC.	Zinc	119-125	protein kinase C, gamma	Rattus norvegicus	179-182
15525775-1	2004	Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons.	Zinc	66-70	carbonic anhydrase 1	Homo sapiens	204-207
15381762-5	2004	As shown by quantitative PCR, Western blot analysis, and immunohistochemistry, intestinal Zip4 was markedly up-regulated in response to Zn-depletion conditions.	Zinc	136-138	solute carrier family 39 (zinc transporter), member 4	Mus musculus	90-94
15381762-11	2004	Intestinal Zip4 up-regulation by Zn-depletion conditions is dampened in metallothionein knockout mice, suggesting that intracellular Zn pools influence these responses.	Zinc	33-35	solute carrier family 39 (zinc transporter), member 4	Mus musculus	11-15
15381762-11	2004	Intestinal Zip4 up-regulation by Zn-depletion conditions is dampened in metallothionein knockout mice, suggesting that intracellular Zn pools influence these responses.	Zinc	133-135	solute carrier family 39 (zinc transporter), member 4	Mus musculus	11-15
15358369-4	2004	By using the Sepharose-IDA-Zn(2+) affinity column, we purified the Escherichia coli expressed hCA-II with an overall recovery of 76%.	Zinc	26-29	carbonic anhydrase 2	Homo sapiens	94-100
15218066-4	2004	External Zn(2+), at micromolar concentrations, activated SUR1/Kir6.2 but induced a small inhibition of SUR2A/Kir6.2 channels.	Zinc	9-11	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	62-68
15218066-4	2004	External Zn(2+), at micromolar concentrations, activated SUR1/Kir6.2 but induced a small inhibition of SUR2A/Kir6.2 channels.	Zinc	9-11	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	109-115
15218066-5	2004	Cytosolic Zn(2+) dose-dependently stimulated both SUR1/Kir6.2 and SUR2A/Kir6.2 channels, with half-maximal effects at 1.8 and 60 microm, respectively, but it did not affect the Kir6.2 subunit expressed alone.	Zinc	10-16	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	55-61
15218066-5	2004	Cytosolic Zn(2+) dose-dependently stimulated both SUR1/Kir6.2 and SUR2A/Kir6.2 channels, with half-maximal effects at 1.8 and 60 microm, respectively, but it did not affect the Kir6.2 subunit expressed alone.	Zinc	10-16	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	72-78
15218066-5	2004	Cytosolic Zn(2+) dose-dependently stimulated both SUR1/Kir6.2 and SUR2A/Kir6.2 channels, with half-maximal effects at 1.8 and 60 microm, respectively, but it did not affect the Kir6.2 subunit expressed alone.	Zinc	10-16	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	72-78
15340647-10	2004	Among a series of divalent cations and salts, Cu2+ and Zn2+ were the most potent inhibitors of NAT activity.	Zinc	55-59	bromodomain containing 2	Homo sapiens	95-98
15269838-6	2004	In this study, we demonstrate that HPRG binds with high affinity to FGF-2-stimulated human umbilical vein endothelial cells (HUVEC) and immobilized tropomyosin in a Zn2+ or pH-dependent manner, and that this interaction is mediated by the H/P domain of HPRG.	Zinc	165-169	histidine rich glycoprotein	Homo sapiens	35-39
15102849-7	2004	However, in contrast to MMP-2, the binding mode of SB-3CT to the catalytic zinc ion of TACE is different in the length of the Zn-S(SB-3CT) bond distance and the total effective charge of the catalytic zinc ion.	Zinc	126-130	ADAM metallopeptidase domain 17	Homo sapiens	87-91
35191200-4	2022	In combination with the Zn anode, the PASP-Tempo composite electrode exhibited rapid charging/discharging and superior cyclic stability with reversible two-electron redox reaction in an aqueous electrolyte.	Zinc	24-26	carboxypeptidase B1	Homo sapiens	38-42
35387998-4	2022	The lab-scale Zn    Se@C cell delivers a discharge voltage of about 1.2 V at 0.5 A g-1 and an initial discharge capacity of 1263 mAh gSe-1.	Zinc	14-16	Gse1 coiled-coil protein	Homo sapiens	133-138
35387998-5	2022	Interestingly, when a specific charging current of 6 A g-1 is applied, the Zn    Se@C cell delivers a stable discharge capacity of around 900 mAh gSe-1 independently from the discharge rate.	Zinc	75-77	Gse1 coiled-coil protein	Homo sapiens	146-151
35402594-0	2022	TRPC6 ameliorates renal ischemic reperfusion injury by inducing Zn2+ influx and activating autophagy to resist necrosis.	Zinc	64-68	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	0-5
35402594-8	2022	Results: Our results verified TRPC6 could markedly enhance viability, Zn2+ influx, and autophagy, and suppressed necrosis in OGD/R HK-2 cells.	Zinc	70-74	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	30-35
35402594-10	2022	Rescue experiment results also showed TRPC6 could prevent necrosis and facilitate Zn2+ influx and autophagy of OGD/R HK-2 cells by inducing Zn2+ influx and autophagy.	Zinc	82-86	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	38-43
35402594-10	2022	Rescue experiment results also showed TRPC6 could prevent necrosis and facilitate Zn2+ influx and autophagy of OGD/R HK-2 cells by inducing Zn2+ influx and autophagy.	Zinc	140-144	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	38-43
35402594-11	2022	Moreover, TRPC6 could ameliorate kidney injury, block necrosis, and enhance autophagy in RIRI model rats by promoting Zn2+ influx and autophagy.	Zinc	118-122	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	10-15
35402594-12	2022	Conclusions: TRPC6 could prevent necrosis and induce autophagy to alleviate RIRI by accelerating Zn2+ influx and autophagy.	Zinc	97-101	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	13-18
35280547-7	2022	Application of various levels of Zn significantly improved the CAT, SOD, POD and ASP activities at 40% WHC compared with control treatment.	Zinc	33-35	SOD	Triticum aestivum	68-71
35112232-3	2022	Eleven studies were identified and used to analyze the effect of diets with or without Zn supplementation on feed intake, feed conversion ratio (FCR), hen day egg production (HDEP), egg weight (EW), egg mass (EM), Haugh unit (HU) scores, eggshell thickness (EST), eggshell weight (ESW), and blood Zn concentrations in laying hens.	Zinc	87-89	ESW	Gallus gallus	281-284
35013289-4	2022	Compared to the bare TiO2 group, Zn2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%.	Zinc	33-37	interleukin 10	Homo sapiens	145-150
35013289-4	2022	Compared to the bare TiO2 group, Zn2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%.	Zinc	33-37	interleukin 10	Homo sapiens	318-323
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	42-46	neutrophil cytosolic factor 2	Mus musculus	65-72
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	42-46	solute carrier family 39 (zinc transporter), member 2	Mus musculus	77-81
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	42-46	neutrophil cytosolic factor 2	Mus musculus	245-252
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	209-213	neutrophil cytosolic factor 2	Mus musculus	65-72
15084143-10	2004	In contrast with the ecto-ADP-ribosyl cyclase (CD38), the cyclization and base-exchange reaction of the skeletal muscle isoform was inhibited by Cu2+ and Zn2+, while other bivalent cations such as Ca2+, Mg2+ and Mn2+ had virtually no effect.	Zinc	154-158	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Oryctolagus cuniculus	47-51
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	209-213	solute carrier family 39 (zinc transporter), member 2	Mus musculus	77-81
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	209-213	neutrophil cytosolic factor 2	Mus musculus	245-252
15137746-13	2004	Nip appears susceptible to Zn-attack when the alpha subunit is in the open conformation and protected from attack when it is in the closed conformation.	Zinc	27-29	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	0-3
35296207-12	2022	In conclusion, an increase of p67phox expression in response to Zn2+ is an intrinsic adaptive response to I/R and leads to cardioprotection against I/R by upregulating ZIP2 via STAT3.	Zinc	64-68	neutrophil cytosolic factor 2	Mus musculus	30-37
2604719-7	1989	Ca2+ binding to the S100b.Zn2+6 complex, studied by flow-dialysis and fluorescence measurements showed that, although Zn2+ ions increase the affinity of S100b protein for Ca2+, the Ca2+-binding sequence was not changed.	Zinc	26-30	S100 calcium binding protein B	Bos taurus	20-25
15070393-2	2004	CAII, through the Zn(2+)-bound hydroxide, catalyzes the deceptively simple reaction: CO(2) + H(2)O &lt;==&gt; HCO(3)(-) + H(+).	Zinc	18-20	carbonic anhydrase 2	Homo sapiens	0-4
15070393-3	2004	The accepted mechanism for CAII would predict that water would be bound to the Zn(2+) at pH 5 and hydroxide would be bound at pH 8.5.	Zinc	79-81	carbonic anhydrase 2	Homo sapiens	27-31
15045055-1	2004	The novel cyclodecapeptide c(GMTCSGCSRP) is able to bind soft metals with a selectivity for Hg(2+) and Cu(+) over Pb(2+), Cd(2+) and Zn(2+), and is demonstrated to be an excellent structural model of the binding loop of the copper metallochaperone Atx1 in its apo and mercury loaded forms.	Zinc	133-135	antioxidant 1 copper chaperone	Homo sapiens	248-252
2604719-7	1989	Ca2+ binding to the S100b.Zn2+6 complex, studied by flow-dialysis and fluorescence measurements showed that, although Zn2+ ions increase the affinity of S100b protein for Ca2+, the Ca2+-binding sequence was not changed.	Zinc	26-30	S100 calcium binding protein B	Bos taurus	153-158
2619040-2	1989	The metal ions, Cu(II), Ni(II) and Zn(II), were immobilized by iminodiacetic acid (IDA) coupled to TSK gel 5PW (10 microns).	Zinc	35-41	tsukushi, small leucine rich proteoglycan	Homo sapiens	99-102
14762707-12	2004	The complex stability orders for both1 and2 are Ca(II)&lt;Mg(II)&lt;Zn(II)&lt;Cu(II).	Zinc	68-70	carbonic anhydrase 2	Homo sapiens	48-54
15117453-0	2004	Zn2+ binding to cysteine-rich domain of extracellular human immunodeficiency virus type 1 Tat protein is associated with Tat protein-induced apoptosis.	Zinc	0-4	Tat	Human immunodeficiency virus 1	90-93
15117453-0	2004	Zn2+ binding to cysteine-rich domain of extracellular human immunodeficiency virus type 1 Tat protein is associated with Tat protein-induced apoptosis.	Zinc	0-4	Tat	Human immunodeficiency virus 1	121-124
2553103-6	1989	Zn2+, Cd2+, Ni2+ and Mn2+ each inhibited Ca2+ inflow through the receptor-activated Ca2+ inflow system.	Zinc	0-4	carbonic anhydrase 2	Homo sapiens	41-44
2553103-6	1989	Zn2+, Cd2+, Ni2+ and Mn2+ each inhibited Ca2+ inflow through the receptor-activated Ca2+ inflow system.	Zinc	0-4	carbonic anhydrase 2	Homo sapiens	84-87
15070437-2	2004	The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption.	Zinc	21-23	solute carrier family 39 member 4	Homo sapiens	87-92
15070437-2	2004	The cloning of human Zn transporters ZnT-like transporter 1 (hZTL1)/ZnT5 (SLC30A5) and hZIP4 (SLC39A4) were major advances in the understanding of the molecular mechanisms of dietary Zn absorption.	Zinc	21-23	solute carrier family 39 member 4	Homo sapiens	94-101
2775217-7	1989	As purified human plasma carboxypeptidase N and pancreatic carboxypeptidase B were also activated more at pH 5.5, we conclude that the increased activation by CoCl2 is due to the enhanced dissociation of Zn2+ below the pKa of the ligands that co-ordinate the cofactor in the protein.	Zinc	204-208	carboxypeptidase B1	Homo sapiens	48-77
14690509-6	2004	The identified candidate genes encode proteins closely related to the following A. thaliana proteins: AtZIP6, a putative cellular Zn uptake system and member of the zinc-regulated transporter (ZRT)-iron regulated transporter (IRT)-like protein (ZIP)-family of metal transporters, the putative P-type metal ATPase AtHMA3, the cation diffusion facilitator ZAT/AtCDF1, and the nicotianamine synthase AtNAS3.	Zinc	130-132	Argonaute family protein	Arabidopsis thaliana	104-107
2662962-2	1989	IMAC of proteins on transition metals (Co, Ni, Cu, Zn) can be rationalized in terms of the coordination of histidine residues.	Zinc	51-53	C-C motif chemokine ligand 26	Homo sapiens	0-4
14757933-9	2003	Considering that the positivity to Timm"s reaction is based on the presence of free or loosely bound Zn2+ ions within synaptic terminals and that Zn2+ ions are reported to be accumulated by hippocampal neurons when tissue injury occurs, the increased area of the mossy fibres in CA3 field of Al(III)-treated rats could indicate increased hippocampal damage in these animals.	Zinc	146-150	carbonic anhydrase 3	Rattus norvegicus	279-282
2496005-4	1989	The Cd2+ fraction can be divided with EDTA and Zn2+.	Zinc	47-51	T-cell surface antigen CD2	Oryctolagus cuniculus	4-7
12869552-7	2003	Oligonucleotide and Zn2+ binding is well retained in the fusion protein, which is the first example of acquisition of a functional nucleic acid binding module by the DNA repair factor dUTPase.	Zinc	20-24	Deoxyuridine triphosphatase	Drosophila melanogaster	184-191
12869571-0	2003	Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.	Zinc	204-208	ubiquitin conjugating enzyme E2 G2	Homo sapiens	78-82
12869571-6	2003	Additional studies showed that the Zn2+ chelator N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine blocked InsP3R ubiquitination, suggesting that a RING finger domain-containing E3 is also involved in this process.	Zinc	35-39	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	108-114
12974644-4	2003	Studies with Zn(2+), as a redox inactive surrogate for copper, show that one Zn(2+) binds to four-electron-reduced QSOX by diverting electrons away from the flavin and into two of the three redox active disulfide bridges in the enzyme.	Zinc	13-15	quiescin sulfhydryl oxidase 1	Homo sapiens	115-119
12974644-4	2003	Studies with Zn(2+), as a redox inactive surrogate for copper, show that one Zn(2+) binds to four-electron-reduced QSOX by diverting electrons away from the flavin and into two of the three redox active disulfide bridges in the enzyme.	Zinc	77-79	quiescin sulfhydryl oxidase 1	Homo sapiens	115-119
12974644-6	2003	Using tris(2-carboxyethyl)phosphine hydrochloride (TCEP), an alternate substrate of QSOX that binds Zn(2+) relatively weakly (unlike dithiothreitol), allows rapid inhibition of oxidase activity to be demonstrated at low micromolar metal levels.	Zinc	100-102	quiescin sulfhydryl oxidase 1	Homo sapiens	84-88
2489045-1	1989	We have employed a retroviral vector, ZN(Smu/S gamma 2b)tk1, as a means of introducing immunoglobulin heavy chain (IgH) switch (S) region sequences into B cell lines to directly measure their switch-recombinase activities.	Zinc	38-40	immunoglobulin heavy constant gamma 2B	Mus musculus	47-55
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Zinc	54-56	CD8a molecule	Homo sapiens	4-7
2484545-7	1988	CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with ConA stimulation in presence of Zn or Fe.	Zinc	109-111	CD8a molecule	Homo sapiens	4-7
13129323-6	2003	The Zn2+-sensing properties of one member of this class are similar to those of the parent ZP1 sensor, with slightly tighter binding and lower background signal.	Zinc	4-8	zona pellucida glycoprotein 1	Homo sapiens	91-94
2484545-8	1988	The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8 positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth of B cells higher than T cells.	Zinc	196-198	CD8a molecule	Homo sapiens	202-205
2484545-8	1988	The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8 positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth of B cells higher than T cells.	Zinc	196-198	CD8a molecule	Homo sapiens	202-205
3183774-5	1988	Plasma Zn was significantly positively correlated with both plasma retinol and PRBP, but significantly negatively correlated only for the detection threshold of NaCl concentration.	Zinc	7-9	retinol binding protein 4	Homo sapiens	79-83
14511320-3	2003	PARP was activated in cultured mouse cortical astrocytes after a toxic acute Zn2+ exposure (350 microm Zn2+ for 15 min), but not in cortical neurons or glia after exposure to a toxic chronic Zn2+ exposure (40 microm Zn2+ for 1-4 h), an exposure sufficient to deplete NAD+ and ATP levels.	Zinc	77-81	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-4
14511320-3	2003	PARP was activated in cultured mouse cortical astrocytes after a toxic acute Zn2+ exposure (350 microm Zn2+ for 15 min), but not in cortical neurons or glia after exposure to a toxic chronic Zn2+ exposure (40 microm Zn2+ for 1-4 h), an exposure sufficient to deplete NAD+ and ATP levels.	Zinc	103-107	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-4
14511320-3	2003	PARP was activated in cultured mouse cortical astrocytes after a toxic acute Zn2+ exposure (350 microm Zn2+ for 15 min), but not in cortical neurons or glia after exposure to a toxic chronic Zn2+ exposure (40 microm Zn2+ for 1-4 h), an exposure sufficient to deplete NAD+ and ATP levels.	Zinc	103-107	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-4
14511320-3	2003	PARP was activated in cultured mouse cortical astrocytes after a toxic acute Zn2+ exposure (350 microm Zn2+ for 15 min), but not in cortical neurons or glia after exposure to a toxic chronic Zn2+ exposure (40 microm Zn2+ for 1-4 h), an exposure sufficient to deplete NAD+ and ATP levels.	Zinc	103-107	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-4
14511320-5	2003	These data suggest PARP activation may contribute to more fulminant forms of Zn2+-induced neuronal death.	Zinc	77-81	poly (ADP-ribose) polymerase family, member 1	Mus musculus	19-23
3341767-0	1988	A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets.	Zinc	29-33	prothrombin	Oryctolagus cuniculus	69-77
2821276-8	1987	The structure of tonin that has been determined is not in its active conformation, but one that has been perturbed by the binding of Zn2+ in the active site.	Zinc	133-137	kallikrein 1-related peptidase C2	Rattus norvegicus	17-22
12890779-7	2003	This stimulus also leads to even greater Zn elevations in area CA1 that is only weakly stained by the Timm"s method.	Zinc	41-43	carbonic anhydrase 1	Homo sapiens	63-66
3722149-2	1986	Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein.	Zinc	122-126	S100 calcium binding protein B	Bos taurus	95-100
12809498-8	2003	WSCP binds Chl a, Chl b, bacteriochlorophyll a, and the Zn derivative of Chl a but not pheophytin a, indicating that the central metal ion in Chl is essential for binding.	Zinc	56-58	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	0-4
3722149-2	1986	Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein.	Zinc	122-126	S100 calcium binding protein B	Bos taurus	153-158
3718228-7	1986	Since both Cd2+ and Hg2+ reduce the foetal uptake of 65Zn and the foetal concentration of Zn, but only Cd2+ interferes with DNA synthesis, it is unlikely that the inhibition of the metabolism of thymidine can be attributed to reduction in thymidine kinase activity in consequence of foetal Zn deficiency.	Zinc	55-57	Cd2 molecule	Rattus norvegicus	11-14
12713833-4	2003	Based on the X-ray crystal structure of the adducts of hCA II with ureate and hydroxamate inhibitors, the hypothetical binding of hydroxyurea is proposed to be achieved in deprotonated state, with the nitrogen atom coordinated to Zn(II), and the OH group of the inhibitor making a hydrogen bond with Thr 199.	Zinc	230-236	carbonic anhydrase 2	Homo sapiens	55-61
12617904-3	2003	The X-ray structure of the complex of topiramate with hCA II has been solved and it revealed a very tight association of the inhibitor, with a network of seven strong hydrogen bonds fixing topiramate within the active site, in addition to the Zn(II) coordination through the ionized sulfamate moiety.	Zinc	243-249	carbonic anhydrase 2	Homo sapiens	54-60
18968965-3	2003	The method was applied to the simultaneous determination of Na(I), Ca(II), Mg(II) and Zn(II) in drinking water with satisfactory results and a detection limit of 32 ng ml(-1) for Zn(II) was obtained.	Zinc	179-181	carbonic anhydrase 2	Homo sapiens	67-73
12377780-3	2002	We have identified the IQGAP1 protein as the major cytoplasmic S100B target protein in different rat and human glial cell lines in the presence of Zn(2+) and Ca(2+).	Zinc	147-149	S100 calcium binding protein B	Rattus norvegicus	63-68
12357749-2	2002	The first part of this review discusses improvements in the syn-selective direct catalytic enantioselective aldol reaction and 1,4-addition reaction of a 2-hydroxyacetophenone derivative using a Zn-linked-BINOL complex.	Zinc	195-197	synemin	Homo sapiens	60-63
12220840-5	2002	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn(2+) coordination into mice enhanced induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), specifically in the liver to a significantly greater extent than free natural IFN-beta.	Zinc	67-73	interferon beta 1, fibroblast	Mus musculus	29-37
12220840-5	2002	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn(2+) coordination into mice enhanced induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), specifically in the liver to a significantly greater extent than free natural IFN-beta.	Zinc	67-73	interferon beta 1, fibroblast	Mus musculus	259-267
12221648-4	2002	Zn2+ is more efficient on DNA/His-pLK complexes: the number of EGFP-positive cells increased from 1% to more than 40%.	Zinc	0-4	polo like kinase 1	Homo sapiens	34-37
12181280-1	2002	Permeation of the endogenous cation Zn2+ through calcium-permeable AMPA/kainate receptor-gated (Ca-A/K) channels might subserve pathological and/or physiological signalling roles.	Zinc	36-40	nucleotriphosphatase	Mus musculus	96-102
12181280-10	2002	These results provide direct evidence that Zn2+ can carry currents through Ca-A/K channels, and that there is little interference between Ca2+ and Zn2+ in permeating these channels.	Zinc	43-47	nucleotriphosphatase	Mus musculus	75-81
12121793-3	2002	[Co(emni)(2)Br(2)], and [Zn(emni)(2)X(2)] (X(-)=Cl, Br) stabilize zig-zag chains, and a 2D supramolecular structure is formed by inter-chain contacts through inter-molecular hydrogen-bonding.	Zinc	25-28	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	70-73
12059205-0	2002	Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5).	Zinc	46-48	cytochrome b	Bos taurus	63-75
12020852-9	2002	Combining pharmacological approaches, we found that voltage-dependent Ca(2+) channels, Ca(2+) stores and a putative Zn(2+)-sensitive extracellular Ca(2+) entry, respectively, makes 61.0, 25.1, and 13.9% contribution to the [Ca(2+)](i) increase caused by Abeta.	Zinc	116-122	amyloid beta precursor protein	Rattus norvegicus	254-259
12072966-2	2002	Isolated MT-3 contains four Cu(I) and three Zn(II) ions organized in homometallic metal-thiolate clusters located in two independent protein domains.	Zinc	44-46	metallothionein 3	Homo sapiens	9-13
11972793-2	2002	The binding specificity of the PrnA Zn cluster differs from that of the Gal4p/Ppr1p/UaY/Put3p group of proteins.	Zinc	36-38	Put3p	Saccharomyces cerevisiae S288C	88-93
11850455-2	2002	Studies in cultured neurons have revealed that of the three major routes of divalent cation entry, NMDA channels, voltage-sensitive Ca2+ channels (VSCCs), and Ca2+-permeable AMPA/kainate (Ca-A/K) channels, Ca-A/K channels exhibit the highest permeability to exogenously applied Zn2+.	Zinc	278-282	nucleotriphosphatase	Mus musculus	188-194
11526114-2	2001	Cancer-predisposing missense mutations in the RING domain of BRCA1 primarily target Zn(2+)-liganding residues.	Zinc	84-90	BRCA1 DNA repair associated	Homo sapiens	61-66
11526114-5	2001	Limited proteolysis of BRCA1/BARD1 complexes, monitored by matrix-assisted laser desorption ionization time-of-flight spectrometry, show that the mutations cause a local structural perturbation that is primarily confined to the second Zn(2+) binding loop of the BRCA1 subunit.	Zinc	235-237	BRCA1 DNA repair associated	Homo sapiens	23-28
11526114-5	2001	Limited proteolysis of BRCA1/BARD1 complexes, monitored by matrix-assisted laser desorption ionization time-of-flight spectrometry, show that the mutations cause a local structural perturbation that is primarily confined to the second Zn(2+) binding loop of the BRCA1 subunit.	Zinc	235-237	BRCA1 associated RING domain 1	Homo sapiens	29-34
11527967-2	2001	Two high affinity Zn(2+) binding sites were engineered in the otherwise Zn(2+)-insensitive rat gamma-aminobutyric acid (GABA) transporter-1 (rGAT-1) based on structural information derived from Zn(2+) binding sites engineered previously in the homologous dopamine transporter.	Zinc	18-24	solute carrier family 6 member 12	Rattus norvegicus	95-139
11454945-6	2001	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn2+ coordination enhanced liver induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), to a greater extent than that by free IFN-beta, although the 2-5AS levels in the liver depended on the mixing ratio of the IFN-beta/DTPA residue of DTPA-pullulan/Zn2+.	Zinc	337-341	interferon beta 1, fibroblast	Mus musculus	29-37
11454945-7	2001	In addition, the duration of the liver 2-5AS induction by the IFN-beta-DTPA-pullulan conjugate with Zn2+ coordination was longer than that by free IFN-beta.	Zinc	100-104	interferon beta 1, fibroblast	Mus musculus	62-70
3086246-2	1986	In the present paper, response changes in Zn biodistribution (mice) and Zn excretion through the pancreatic duct (rats) due to the stimulation of gastro-intestinal hormones like secretin, CCK-PZ (exocrine stimulation) and glucose (endocrine stimulation) were studied.	Zinc	72-74	cholecystokinin	Mus musculus	188-191
11454945-8	2001	The liver targeting of IFN-beta by DTPA-pullulan with Zn2+ coordination may be a promising IFN therapy.	Zinc	54-58	interferon beta 1, fibroblast	Mus musculus	23-31
3086246-3	1986	Under these stimuli, the pancreatic secretion of radioactive Zn through cannulated pancreatic duct showed increased Zn secretion only under the CCK-PZ effect, 3 h post 65Zn (t1/2 = 270 d) injection.	Zinc	61-63	cholecystokinin	Mus musculus	144-147
3086246-5	1986	Thus, the effective mobilization of the injected radioactive Zn, upon exocrine stimulation, represented by CCK-PZ, favored the exploration of a functional study of the pancreas with the positron computed tomograph (PCT) using short lived nuclide labeled 62Zn-EDDA in dog.	Zinc	61-63	cholecystokinin	Mus musculus	107-110
4081618-3	1985	Zn2+ at concentrations from 0.25-4.0 mmol/l inhibited the release of ECP in a dose-dependent fashion, with or without Ca2+ and Mg2+ in the medium.	Zinc	0-4	ribonuclease A family member 3	Homo sapiens	69-72
11444968-6	2001	Those PBGS utilizing a catalytic Zn(2+) are more sensitive to 4,7-DOSA than those that do not.	Zinc	33-35	aminolevulinate dehydratase	Homo sapiens	6-10
4019447-2	1985	The effects of divalent cations (Zn2+, Cd2+, Ca2+, Mg2+) on the cytosol androgen receptor were determined by sedimentation into sucrose gradients.	Zinc	33-37	androgen receptor	Rattus norvegicus	72-89
11166545-7	2001	When zN is small, the suspensions are stable for large 1/lambda but show strong aggregation for small 1/lambda.	Zinc	5-7	LARGE xylosyl- and glucuronyltransferase 1	Homo sapiens	49-56
11134057-1	2001	Multiple or pleiotropic drug resistance often arises in the yeast Saccharomyces cerevisiae due to genetic alterations of the functional state of the Cys(6)-Zn(II)(2) transcription factors Pdr1p and Pdr3p.	Zinc	156-158	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	198-203
4019447-6	1985	The potentiating effect of Zn2+ on formation of the 8.6 S receptor (in the absence of Ca2+) and the 6.2 S receptor (in the presence of Ca2+) requires both the 4.5 S receptor and the 8 S androgen receptor-promoting factor.	Zinc	27-31	androgen receptor	Rattus norvegicus	186-203
4007160-3	1985	In the presence of Zn2+ from 0.1 to 1 mM (free concentration), rat S-100 and ox S-100a and S-100b inhibit assembly, while S-100a0 is without effect.	Zinc	19-23	S100 calcium binding protein B	Rattus norvegicus	91-97
11156944-10	2001	We presume that the mechanism of TACE activation by H2O2 is due to an oxidative attack of the pro-domain thiol group and disruption of its inhibitory coordination with the Zn++ in the catalytic domain of TACE.	Zinc	172-176	ADAM metallopeptidase domain 17	Homo sapiens	204-208
11160420-2	2001	In addition to a slow and persistent component of redox modulation common to all NMDA receptors, NR1/NR2A receptors uniquely have a rapid and reversible component that has been variously attributed to redox or Zn(2+) effects.	Zinc	210-212	glutamate receptor ionotropic, NMDA 2A-like	Xenopus laevis	101-105
3890940-6	1985	Calculations based on Forster energy-transfer theory predict that the Co(II) [or Zn(II) in vivo] and Eu(III) [or Ca(II) in vivo] binding sites are separated by 9.6 +/- 0.5 A.	Zinc	81-87	carbonic anhydrase 2	Homo sapiens	113-119
3964836-8	1985	The occupancy of the two high-affinity Zn2+ binding sites was responsible for most of the Zn2+-induced conformational changes in the rat S100b protein.	Zinc	39-43	S100 calcium binding protein B	Rattus norvegicus	137-142
3964836-8	1985	The occupancy of the two high-affinity Zn2+ binding sites was responsible for most of the Zn2+-induced conformational changes in the rat S100b protein.	Zinc	90-94	S100 calcium binding protein B	Rattus norvegicus	137-142
6430565-5	1984	All kex2 mutants examined (three independent alleles) lack a Zn++-sensitive membrane-associated endopeptidase with specificity for cleaving on the carboxyl side of a pair of basic residues.	Zinc	61-65	kexin KEX2	Saccharomyces cerevisiae S288C	4-8
6327055-6	1984	While the hMT-IIA promoter is responsive to Cd++, Zn++, and glucocorticoids, the hMT-IA promoter mediates response only to Cd++.	Zinc	50-54	histamine N-methyltransferase	Homo sapiens	10-13
6715334-2	1984	A stable, reversibly sulfhydryl-modified, Zn2+-free porphobilinogen synthase (mod-apo-PBG synthase) has been prepared using methylmethanethiosulfonate.	Zinc	42-46	aminolevulinate dehydratase	Homo sapiens	52-76
7097790-5	1982	The 7-fold increase in plasma GOT and 12-fold increase in GPT after PA (120 mg/kg) were reduced to 2.4- and 2.1-fold, respectively, by Zn pretreatment.	Zinc	135-137	glutamic--pyruvic transaminase	Rattus norvegicus	58-61
7338951-8	1981	Cd and Zn also inhibited steroid 21-hydroxylase activity in adrenal microsomes, but Pb had no effect on steroid metabolism.	Zinc	7-9	steroid 21-hydroxylase	Cavia porcellus	25-47
6114094-3	1981	This chelator has a much higher association constant for Zn2+ than for the Mn2+ needed for glycosyltransferase reactions, enabling selective chelation of Zn2+.	Zinc	154-158	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)	Gallus gallus	91-110
11177815-1	2001	We present a theory for recent STM studies of Zn impurities in the superconductor Bi2Sr2CaCu2O8+delta, using insights from NMR experiments which show that there is a net S = 1/2 moment on the Cu ions near the Zn.	Zinc	46-48	sulfotransferase family 1A member 3	Homo sapiens	31-34
11177815-1	2001	We present a theory for recent STM studies of Zn impurities in the superconductor Bi2Sr2CaCu2O8+delta, using insights from NMR experiments which show that there is a net S = 1/2 moment on the Cu ions near the Zn.	Zinc	209-211	sulfotransferase family 1A member 3	Homo sapiens	31-34
11440182-13	2001	Another general observation was that the complexes with Mn dications were more stable than those with Zn dications for both PP1c and PP2Ac units.	Zinc	102-104	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	124-128
7217218-1	1981	A metallothionein-like protein (MTP) is synthesized in normal diploid human skin fibroblasts cultured in Zn- or Cu-supplemented medium.	Zinc	105-107	microsomal triglyceride transfer protein	Homo sapiens	32-35
7217218-5	1981	However, Menkes fibroblasts retain the ability to incorporate 65Zn into MTP in response to Zn supplementation of the medium.	Zinc	64-66	microsomal triglyceride transfer protein	Homo sapiens	72-75
526041-2	1979	In an in vitro experimental system, a study was also made of how the erythrocyte delta-aminolevulinic acid dehydratase activity varies on the action of the activators -SH and Zn2+.	Zinc	175-179	aminolevulinate dehydratase	Homo sapiens	81-118
526041-3	1979	It was found that, compared to the healthy controls, the erythrocyte delta-aminolevulinic acid dehydratase activity of porphyria cutanea tarda patients is significantly decreased, but it is restored to the original activity level on the addition of -SH and Zn2+.	Zinc	257-261	aminolevulinate dehydratase	Homo sapiens	69-106
117692-1	1978	In the present study use was made of the chelating ability of EDTA and the activating property of some metal ions Ca(II), Mg(II) or Mn(II) to counteract the inhibitory effect of Cu(II), Co(II), Pb(II) or Zn(II) ions on the B6-dependent kynurenine hydrolase and on kynurenine aminotransferase.	Zinc	204-210	carbonic anhydrase 2	Homo sapiens	114-120
32840726-7	2021	The expression of caspase-3 gene was significantly increased in the presence of the combination high Zn/high glucose with and without the presence of insulin and IL6 in the culture medium Fas expression instead, showed uneven responses.	Zinc	101-103	caspase 3	Mus musculus	18-27
32840726-9	2021	Bax/Bcl2 ratio was decreased in the presence of high Zn.	Zinc	53-55	BCL2-associated X protein	Mus musculus	0-3
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	cAMP responsive element binding protein 1	Homo sapiens	154-158
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	matrix metallopeptidase 9	Homo sapiens	293-318
33641168-8	2021	Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9).	Zinc	55-59	matrix metallopeptidase 9	Homo sapiens	320-325
33970272-3	2021	Mean Zn concentrations in NAT(BT) are 5.5 mug g-1 greater than in NAT(MT) (p = 0.00056) and 5.1 mug g-1 greater than in HT (p = 0.0026).	Zinc	5-7	bromodomain containing 2	Homo sapiens	26-29
33970272-3	2021	Mean Zn concentrations in NAT(BT) are 5.5 mug g-1 greater than in NAT(MT) (p = 0.00056) and 5.1 mug g-1 greater than in HT (p = 0.0026).	Zinc	5-7	bromodomain containing 2	Homo sapiens	66-69
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	intercellular adhesion molecule 1	Homo sapiens	223-256
33979169-6	2021	Theoretical calculations suggest that this is because the introduction of the electron-withdrawing fluorine substituents reduces the spin density on Zn atoms and weakens the spin-orbit interaction.	Zinc	149-151	spindlin 1	Homo sapiens	133-137
33689144-8	2022	It was determined that in comparison with the normoxia 30 min and 60 min groups, the amount of inward Ca+2 current across TRPM2 channels and mean current density increased in the groups that were exposed to hypercapnia for 30 min and 60 min, while the same values significantly decreased in the hypercapnia groups that Zn, Se, and GSH were applied.	Zinc	319-321	transient receptor potential cation channel subfamily M member 2	Homo sapiens	122-127
33359632-9	2021	They also unravel an intramolecular disulfide bridge that stabilizes the C-terminal tail in a rigid conformation, thus shaping a second Zn-binding site per S100A9 protomer.	Zinc	136-138	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	156-162
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	22-26	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	185-192
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	22-26	catechol-O-methyltransferase	Mus musculus	321-325
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	170-174	solute carrier family 6 (neurotransmitter transporter), member 15	Mus musculus	185-192
33673282-6	2021	Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression.	Zinc	170-174	catechol-O-methyltransferase	Mus musculus	321-325
33560532-8	2021	The CD 4 +  (cluster of differentiation in %) was more (p < 0.05) in Zn supplemented groups.	Zinc	69-71	T-cell surface glycoprotein CD4	Capra hircus	4-8
33253705-0	2021	The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn2+ accumulation.	Zinc	104-108	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	36-67
33253705-3	2021	Notably, excitatory amino acid carrier 1 (EAAC1), known as a cysteine transporter, is involved in Zn2+ homeostasis, and its expressions exhibit a diurnal fluctuation.	Zinc	98-102	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	9-40
33253705-3	2021	Notably, excitatory amino acid carrier 1 (EAAC1), known as a cysteine transporter, is involved in Zn2+ homeostasis, and its expressions exhibit a diurnal fluctuation.	Zinc	98-102	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	42-47
33253705-4	2021	This study aimed to investigate whether time of day of an ischemic insult affects Zn2+ accumulation and neuronal injury and determine whether altered Zn2+ accumulation is modulated by EAAC1 diurnal fluctuation in the hippocampus in a mouse model of ischemic stroke.	Zinc	150-154	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	184-189
33253705-8	2021	These findings suggest that ischemia-induced Zn2+ accumulation displays circadian fluctuations through diurnal variations in EAAC1 expressions and affects susceptibility to ischemic neuronal injury in the hippocampal hilar region.	Zinc	45-49	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	125-130
33477854-8	2021	In addition, ATP1A1 and ATP8 could be used as the key genes to detect K and Zn, respectively.	Zinc	76-78	sodium/potassium-transporting ATPase subunit alpha-1	Anas platyrhynchos	13-19
33064326-2	2021	Here we describe the influence of Cd2+ , Ni2+ , Zn2+ and Cu2+ on root development and vital organization of actin filaments into different cells of Arabidopsis thaliana line expressing GFP-FABD2.	Zinc	48-52	actin-12	Arabidopsis thaliana	108-113
33254959-7	2021	The release of Zn2+ also inhibited the bioactivity in SBF but, in contrast to the release of Mg2+, induced low cell adhesion and proliferation and high ALP activity compared to the control.	Zinc	15-19	ATHS	Homo sapiens	152-155
33305939-8	2020	The combination of CgA-ZapCY1 and CgA-eCALWY-4 allows for measurement of Zn2+ from pM to nM ranges.	Zinc	73-77	chromogranin A	Mus musculus	19-22
33305939-8	2020	The combination of CgA-ZapCY1 and CgA-eCALWY-4 allows for measurement of Zn2+ from pM to nM ranges.	Zinc	73-77	chromogranin A	Mus musculus	34-37
32971353-5	2020	Cd2+ regulated the expression of genes associated with cellular Cu, Zn, and Fe homeostasis, DNA replication leading to cell cycle arrest and apoptosis, and glutathione metabolism.	Zinc	68-70	si:ch211-132g1.1	Danio rerio	0-3
32926024-2	2020	Previously, we have reported that copper ions (Cu2+) markedly exacerbated Zn2+-induced neuronal cell death by potentiating oxidative stress, the endoplasmic reticulum (ER) stress response, and the activation of the c-Jun amino-terminal kinase (JNK) signaling pathway.	Zinc	74-78	mitogen-activated protein kinase 8	Mus musculus	215-242
32926024-2	2020	Previously, we have reported that copper ions (Cu2+) markedly exacerbated Zn2+-induced neuronal cell death by potentiating oxidative stress, the endoplasmic reticulum (ER) stress response, and the activation of the c-Jun amino-terminal kinase (JNK) signaling pathway.	Zinc	74-78	mitogen-activated protein kinase 8	Mus musculus	244-247
33142680-0	2020	Zinc (Zn): The Last Nutrient in the Alphabet and Shedding Light on Zn Efficiency for the Future of Crop Production under Suboptimal Zn.	Zinc	6-8	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	99-103
33142680-0	2020	Zinc (Zn): The Last Nutrient in the Alphabet and Shedding Light on Zn Efficiency for the Future of Crop Production under Suboptimal Zn.	Zinc	67-69	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	99-103
33142680-0	2020	Zinc (Zn): The Last Nutrient in the Alphabet and Shedding Light on Zn Efficiency for the Future of Crop Production under Suboptimal Zn.	Zinc	67-69	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	99-103
33142680-8	2020	Furthermore, future research will address the target genes underlying Zn efficiency and the optimization of Zn efficiency phenotyping for the development of Zn-efficient crop varieties for more sustainable crop production under suboptimal Zn regimes, as well food security of the future.	Zinc	108-110	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	170-174
33142680-8	2020	Furthermore, future research will address the target genes underlying Zn efficiency and the optimization of Zn efficiency phenotyping for the development of Zn-efficient crop varieties for more sustainable crop production under suboptimal Zn regimes, as well food security of the future.	Zinc	108-110	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	170-174
33142680-8	2020	Furthermore, future research will address the target genes underlying Zn efficiency and the optimization of Zn efficiency phenotyping for the development of Zn-efficient crop varieties for more sustainable crop production under suboptimal Zn regimes, as well food security of the future.	Zinc	108-110	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	170-174
33060722-5	2020	Importantly, when the complex also included Zn2+, a significant increase in cell membrane GLUT1 was measured, thus providing a cellular effect similar to insulin, but on a transporter on which insulin has no effect.	Zinc	44-48	solute carrier family 2 member 1	Homo sapiens	90-95
32229323-2	2020	The results showed decreased Cat1 and Cat2 signals for the Zn(II)-loaded MT3 species with respect to the metal-free protein, which might be explained by the arrangement of tetrahedral metal-thiolate coordination environments and the formation of metal clusters.	Zinc	59-65	transient receptor potential cation channel subfamily V member 6	Homo sapiens	29-33
33463313-6	2020	More importantly, the coupled growth of the Sn-enriched and Zn-enriched phases and their volume differences together led to a rod-like morphology of the eutectic according to the volume fraction theory.	Zinc	60-62	kinetochore associated 1	Homo sapiens	126-129
33463313-10	2020	This study showed the potential of rod-like eutectic for the mechanical enhancement of the biodegradable Zn alloy.	Zinc	105-107	kinetochore associated 1	Homo sapiens	35-38
32562453-10	2020	Downregulation of Zn2+ attenuated the increased MMP9 activity, laminin degradation caused by ketamine and significantly reduced ketamine-induced neuronal apoptosis.	Zinc	18-22	matrix metallopeptidase 9	Rattus norvegicus	48-52
32562453-13	2020	Zn2+ downregulation may play a protective role against ketamine-induced neuronal apoptosis through inhibiting MMP9 activity.	Zinc	0-4	matrix metallopeptidase 9	Rattus norvegicus	110-114
32355935-5	2020	Cadmium selenide/zinc sulfide (CdSe/ZnS) core/shell nanoparticles were attached to azido-CTB by strain-promoted alkyne-azide cycloaddition to make a nano-conjugate.	Zinc	36-39	phosphate cytidylyltransferase 1B, choline	Homo sapiens	89-92
32320289-4	2020	Numerous genetic variants in the gene encoding ZnT2 (SLC30A2) are associated with low milk Zn concentration and result in severe Zn deficiency in exclusively breastfed infants.	Zinc	47-49	solute carrier family 30 member 2	Homo sapiens	53-60
32409642-6	2020	Hg2+, Zn2+, Cd2+, and NaN3 (5 mM) were effective peroxidase inhibitors, whereas Cu2+ and Ca2+ enhanced the peroxidase activity.	Zinc	6-10	peroxidase 42	Ziziphus jujuba	49-59
32409642-6	2020	Hg2+, Zn2+, Cd2+, and NaN3 (5 mM) were effective peroxidase inhibitors, whereas Cu2+ and Ca2+ enhanced the peroxidase activity.	Zinc	6-10	peroxidase 42	Ziziphus jujuba	107-117
32052323-5	2020	Crustal enrichment factors (EFcs) of trace elements (V, Cr, Ni, Zn, As, Se, Rb, Cd, Pb, and Bi) in PM1.1 in that called slight air pollution events were always higher than those in that called severe air pollution events and EFcs of Se were up to 2.5 x 104, while EFcs of Pb, Bi, and Cd were over 100.	Zinc	64-66	transmembrane protein 11	Homo sapiens	99-102
31792980-5	2020	We show that Ca2+ is required for high-affinity ligand binding, but Zn2+ and Cu2+ in the presence of Ca2+ behave as negative allosteric modulators of ligand binding to MC4 R.	Zinc	68-72	melanocortin 4 receptor	Homo sapiens	168-173
32195564-3	2020	Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA.	Zinc	75-77	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	17-20
32195564-3	2020	Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA.	Zinc	75-77	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	92-95
32195564-3	2020	Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA.	Zinc	210-213	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	17-20
32195564-3	2020	Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA.	Zinc	210-213	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	92-95
32195564-5	2020	The hybrid cell shows an extremely high stability of 10000 cycles with a record little capacity loss of 0.0027% per cycle, since Zn-reinforced SA-PAM SE successfully inhibits free water molecules from occupying low-spinning metallic sites (Fe-C) in Na0.5FeFe(CN)6.	Zinc	129-131	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	146-149
32267231-5	2020	An additional layer comprising two serines in human TMEM175 increases selectivity further and renders this channel sensitive to 4-aminopyridine and Zn2+.	Zinc	148-152	transmembrane protein 175	Homo sapiens	52-59
31867832-4	2020	DNAzymes that bind 1, 2, and 3 Zn2+ ions, increased their selectivity for Zn2+ over Co2+ ions from approximately 20-, 1000-, to 5000-fold, respectively.	Zinc	31-35	3-hydroxyacyl-CoA dehydratase 3	Homo sapiens	14-20
31867832-4	2020	DNAzymes that bind 1, 2, and 3 Zn2+ ions, increased their selectivity for Zn2+ over Co2+ ions from approximately 20-, 1000-, to 5000-fold, respectively.	Zinc	74-78	3-hydroxyacyl-CoA dehydratase 3	Homo sapiens	14-20
32023031-4	2020	This ZnO@C/GF microelectrode was further successfully applied to the detection of TNT in lake and tap water, indicating its promise as a portable sensor for the electrochemical detection of explosive compounds.	Zinc	5-8	nuclear RNA export factor 1	Homo sapiens	98-101
32065557-7	2020	Regarding the lipase characterization, maximum relative activity was obtained at pH 7.0 and at 35  C. An inhibitory effect was observed for Ca2+, Mn2+, Zn2+, Fe2+, and Cu2+ ions.	Zinc	152-156	probable feruloyl esterase A	Triticum aestivum	14-20
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	zinc transporter	Arabidopsis thaliana	142-146
31862901-7	2019	We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19.	Zinc	110-112	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	158-164
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interleukin 2	Bos taurus	228-241
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interleukin 2	Bos taurus	243-247
30783921-5	2019	More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P &lt; 0.05).	Zinc	22-24	interferon gamma	Bos taurus	260-276
31665668-2	2019	Zn-TNE treated seeds bestowed better seedling vigor index and higher activities of seed stored food mobilizing enzymes (alpha-amylase and protease).	Zinc	0-2	1,4-alpha-glucan-branching enzyme 1, chloroplastic/amyloplastic	Glycine max	120-133
31695039-4	2019	The methyltransferase (MTase) domain of ZCCHC4 is packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal CCHC domain, creating an integrated RNA-binding surface.	Zinc	89-98	zinc finger CCHC-type containing 4	Homo sapiens	40-46
31694210-8	2019	Moreover, the addition of both Si and Zn positively regulate the osteoprotegerin: receptor activator of nuclear factor k-beta ligand (OPG:RANKL) ratio at 21-days for Si-TCP and Zn-TCP scaffolds.	Zinc	38-40	TNF superfamily member 11	Homo sapiens	138-143
31694210-9	2019	These results demonstrate the effects of Si and Zn doped porous beta-TCP scaffolds on the upregulation of osteoblast marker gene expression including OPG, RANKL, BMP-2, and Runx2, indicating the role of trace elements on the effective regulation of late-stage osteoblast cell differentiation markers.	Zinc	48-50	TNF superfamily member 11	Homo sapiens	155-160
31635415-2	2019	Hyperthermia data revealed a sigmoidal dependence of the specific absorption rate (SAR)on the alternating magnetic field (AMF) amplitude, with remarkable saturation SAR values in waterof ~1200 W/gFe+Mn and ~800 W/gFe+Zn for the Mn and Zn ferrites, respectively.	Zinc	217-219	sarcosine dehydrogenase	Homo sapiens	83-86
31635415-2	2019	Hyperthermia data revealed a sigmoidal dependence of the specific absorption rate (SAR)on the alternating magnetic field (AMF) amplitude, with remarkable saturation SAR values in waterof ~1200 W/gFe+Mn and ~800 W/gFe+Zn for the Mn and Zn ferrites, respectively.	Zinc	235-237	sarcosine dehydrogenase	Homo sapiens	83-86
31635415-3	2019	The immobilizationof the MNPs in a solid matrix reduced the maximum SAR values by ~300 W/gFe+Mn, Zn for bothferrites.	Zinc	97-99	sarcosine dehydrogenase	Homo sapiens	68-71
31636470-9	2019	Zn2+ transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC).	Zinc	0-3	death associated protein kinase 3	Homo sapiens	25-28
31636470-9	2019	Zn2+ transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC).	Zinc	0-3	solute carrier family 39 member 4	Homo sapiens	123-127
31636470-9	2019	Zn2+ transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC).	Zinc	40-43	solute carrier family 39 member 4	Homo sapiens	123-127
31330363-8	2019	Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity.	Zinc	34-36	arginase 2	Homo sapiens	153-157
31480251-3	2019	The results show that TC4/Zn composite can be successfully prepared, and gradient microstructures varying from coarse grain to nanocrystalline is formed from the bottom to the upper surface.	Zinc	26-28	RAN pseudogene 1	Homo sapiens	22-25
31480251-8	2019	This paper provides a new method to obtain a TC4/Zn composite with gradient surface microstructures for potential applications in the biomedical field.	Zinc	49-51	RAN pseudogene 1	Homo sapiens	45-48
31632499-2	2019	Zinc-alpha2-glycoprotein 1(AZGP1) is a candidate biomarker for diagnosis and prognosis in cancer.	Zinc	0-11	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	27-32
31632863-3	2019	The pathogenesis of KRS is related to an interrelated metabolism of ATP13A2 with Mn+2 and Zn+2, bioenergetics of mitochondria, autophagy lysosomal dysfunction, and synuclein metabolism.	Zinc	90-92	ATPase cation transporting 13A2	Homo sapiens	68-75
31305986-5	2019	The as-prepared Fe-N/GPC-800, as a cathodic catalyst, is assessed in a Zn-air battery test and delivers an open-circuit voltage of 1.44 V with a power density of 134 mW cm-2 as well as the outstanding durability after 350 cycles at 10 mA cm-2, demonstrating appreciable promise in application of metal-air batteries.	Zinc	71-73	glycophorin C (Gerbich blood group)	Homo sapiens	21-24
31185570-3	2019	These NPL monolayers were employed as acceptors in an energy transfer working model system to pair with CdZnS/ZnS core/shell quantum dots (QDs) as donors.	Zinc	106-109	N-acetylneuraminate pyruvate lyase	Homo sapiens	6-9
30660752-7	2019	Rim2-dependent pyrimidine transport was competed by Zn2+ but not by Fe2+, Fe3+ or Cu2+.	Zinc	52-56	regulating synaptic membrane exocytosis 2	Homo sapiens	0-4
31115566-11	2019	Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO-1 expression compared with the HG group.	Zinc	150-152	heme oxygenase 1	Rattus norvegicus	196-200
31276083-11	2019	We observed that CuZnSOD activity is strongly downregulated in Zn-deficient A. thaliana, in association with an about 94% reduction in the abundance of the CSD2 transcript, a known target of miR398.	Zinc	19-21	copper/zinc superoxide dismutase 2	Arabidopsis thaliana	156-160
30952310-3	2019	Under optimized conditions (1.25 mL of 5 mg L-1 MIP-PEG-ZnS QDs solution, pH 5.0, and 12 min delay time before scanning), the prepared MIP-QDs composite was found to offer high affinity and selectivity for AFs (AFB1, AFB2, AFG1 and AFG2).	Zinc	56-59	AFG1 like ATPase	Homo sapiens	223-227
31095373-0	2019	"Ship in a Bottle" Design of Highly Efficient Bifunctional Electrocatalysts for Long-Lasting Rechargeable Zn-Air Batteries.	Zinc	106-108	inositol polyphosphate-5-phosphatase D	Homo sapiens	1-5
31111849-9	2019	Experiments performed with a mixture of four metal ions, Hg2+, Cd2+, Zn2+ and Ni2+, indicate that this molecular probe may potentially be used in Hg2+-sensing systems under acidic conditions for the measurement of muM range concentrations.	Zinc	69-73	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	146-149
31275928-8	2019	After combination with three-dimensional graphene foam (3DG), the resultant CoFe-CNTF-coated 3DG is used as air-cathode to fabricate a flexible all-solid-state Zn-air battery, which exhibits a high open circuit potential of 1.455 V. Importantly, the fabricated flexible battery can light a light-emitting diode (LED) even when it is bent.	Zinc	160-162	ciliary neurotrophic factor	Homo sapiens	81-85
31137854-0	2019	Development of Hot-Extruded Mg-RE-Zn Alloy Bar with High Mechanical Properties.	Zinc	34-36	alcohol dehydrogenase iron containing 1	Homo sapiens	15-18
30817078-3	2019	We demonstrate that Zn-substitution of neuroglobin, to populate the Zn(II) protoporphyrin IX triplet state, makes it possible to perform light-induced pulsed dipolar experiments on hemeproteins, extending the use of light-induced dipolar spectroscopy to this large class of metalloproteins.	Zinc	20-22	neuroglobin	Homo sapiens	39-50
30762184-4	2019	The results indicated that the total simultaneous adsorption of Cu2+, Zn2+, and PNP onto STAC-En-MMt adsorbent with REn/STAC = 0.75 reached up to 260.27 mmol kg-1 under the condition of pH = 6, ATemp = 40  C, and ATime = 60 min.	Zinc	70-74	SH3 and cysteine rich domain	Homo sapiens	89-93
30762184-8	2019	Compared with Zn2+, Cu2+ had higher affinity for the adsorption sites on STAC-En-MMt.	Zinc	14-18	SH3 and cysteine rich domain	Homo sapiens	73-77
29742958-7	2019	Recent studies provide evidence of differences in sources of Zn2+ and its interactions with mitochondria in CA1 versus CA3 neurons that may pertain to their differential vulnerabilities in disease.	Zinc	61-65	carbonic anhydrase 1	Homo sapiens	108-111
30884854-0	2019	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	Zinc	16-18	Cbl proto-oncogene like 2	Homo sapiens	50-69
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine receptor 1	Homo sapiens	30-35
30727735-2	2019	The approach proposed herein based on the online coupling of asymmetric flow field-flow fractionation (AF4) with inductively coupled plasma-tandem mass spectrometry (ICP-MS/MS) allows for the first time the direct determination of such ratios in CdSe/ZnS core-shell quantum dot:rat monoclonal IgG2a antibody (QD:Ab) conjugate mixtures in a single run without any previous sample preparation (i.e., derivatization).	Zinc	251-254	AF4/FMR2 family member 1	Homo sapiens	103-106
30516222-13	2019	Zn-Replete and Pb-replete MT3 have distinctive circular dichroism spectra, suggestive of structural differences with different metallation status.	Zinc	0-2	metallothionein 3	Homo sapiens	26-29
30342410-4	2019	Surface protection of a CdS-covered CZTS photocathode by a ZnS layer resulted in efficient photoelectrochemical water splitting with a maximum half-cell solar to hydrogen (HC-STH) efficiency of 2.1% and without showing appreciable degradation.	Zinc	59-62	saitohin	Homo sapiens	175-178
30296047-1	2019	A water-soluble meso-carboxy aryl substituted [18] heteroannulene (porphyrin) and its Zn-complex have been found to be viable in targeting alpha-Syn aggregation at all its key microevents, namely, primary nucleation, fibril elongation, and secondary nucleation, by converting the highly heterogeneous and cytotoxic aggresome into a homogeneous population of minimally toxic off-pathway oligomers, that remained unexplored until recently.	Zinc	86-88	synemin	Homo sapiens	145-148
30180347-9	2019	We found correlation between soil Cu and Zn concentrations and the abundance of ARGs and MGE genes.	Zinc	41-43	serpin family A member 2 (gene/pseudogene)	Homo sapiens	80-84
30387407-10	2018	After 4 weeks of feeding a high-dosage Zn diet, the relative CD4+ T-cell count (P&lt;0 05) and the relative CD8beta + T-cell count (P&lt;0 1) were reduced compared with the MZn group.	Zinc	39-41	T-cell surface glycoprotein CD8 beta chain	Sus scrofa	108-115
29806484-3	2018	The structure of human Zn,Cu-CA II has been solved which contains a copper ion bound at its N-terminal, coordinated to His4 and His64.	Zinc	23-25	carbonic anhydrase 2	Homo sapiens	29-34
30397150-4	2018	This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of the Zn importer ZIP1 (target of miR-182), leading to a reduction of prostatic Zn.	Zinc	117-119	microRNA 182	Homo sapiens	265-272
30397150-5	2018	This inverse relationship between miR-182 and ZIP1 also occurs in human prostate cancer tissue, which is known for Zn loss.	Zinc	115-117	microRNA 182	Homo sapiens	34-41
30226602-12	2018	It was revealed that cyclic peptide 2 bound deeply in the binding pocket of MMP9 and had interaction with the active-site Zn2+ ion in the catalytic domain.	Zinc	122-126	matrix metallopeptidase 9	Homo sapiens	76-80
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	76-78	solute carrier family 30 member 2	Homo sapiens	213-217
30221266-7	2018	At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1.	Zinc	128-130	solute carrier family 30 member 2	Homo sapiens	213-217
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	39-43	brain-derived neurotrophic factor	Rattus norvegicus	244-248
28421879-8	2018	CONCLUSION: Our data suggest that free Zn2+ deficiency-induced hippocampal neuronal injury correlates with free Zn2+ deficiency-induced changes in methylation-related protein gene expression including DNMT3a/DNMT1/MeCP2 and GADD45b, as well as BDNF gene expression.	Zinc	112-116	brain-derived neurotrophic factor	Rattus norvegicus	244-248
29743301-7	2018	HtHV1 opening is exquisitely sensitive to pHo, whereas closing is nearly independent of pHo Zn2+ and Cd2+ inhibit HtHV1 currents in the micromolar range, slowing activation, shifting the proton conductance-voltage (gH-V) relationship to more positive potentials, and lowering the maximum conductance.	Zinc	92-96	growth hormone 2	Homo sapiens	215-219
29755482-6	2018	Both, silicon and micronutrient treatments were associated with increased activity of superoxide dismutase in shoot and roots (as a key enzyme for detoxification of reactive oxygen species, depending on Zn and Mn as cofactors), increased tissue concentrations of phenolics, proline, and antioxidants, but reduced levels of H2O2.	Zinc	203-205	superoxide dismutase	Zea mays	86-106
29106077-5	2018	Further, the presence of oxygen increased the interaction of selenoxides with the delta-ALAD active site by O...Zn coordination.	Zinc	112-114	aminolevulinate dehydratase	Homo sapiens	82-92
29512390-2	2018	Mg2+ and Zn2+ activate and inhibit, respectively, protein tyrosine phosphatase 1B (PTP1B).	Zinc	9-13	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	50-81
29512390-2	2018	Mg2+ and Zn2+ activate and inhibit, respectively, protein tyrosine phosphatase 1B (PTP1B).	Zinc	9-13	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	83-88
29223455-7	2018	Moreover, the AuNPsTyr aggregated by Cr3+ or Pb2+ (a combination of them) show excellent selectivity compared to other metal ions (Cr3+, Pb2+, Fe2+,Cu2+,Zn2+,Cr6+,Ni2+,Co2+,Hg2+,Mn2+,Mg2+,Ca2+,Cd2+).	Zinc	153-157	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	158-161
29281059-5	2018	The T-DNA insertion in the AtPCS1 mutant cad1-6 causes a truncation in the C-terminal regulatory domain that differentially affects activation by cadmium (Cd) and zinc (Zn).	Zinc	169-171	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	27-33
29281059-5	2018	The T-DNA insertion in the AtPCS1 mutant cad1-6 causes a truncation in the C-terminal regulatory domain that differentially affects activation by cadmium (Cd) and zinc (Zn).	Zinc	169-171	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	41-45
29281059-7	2018	Both cad1-6 and cad1-3 showed increased As distribution to shoots compared with Col-0, whereas Zn accumulation in shoots was equally lower in cad1-6 and cad1-3.	Zinc	95-97	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	142-148
29281059-7	2018	Both cad1-6 and cad1-3 showed increased As distribution to shoots compared with Col-0, whereas Zn accumulation in shoots was equally lower in cad1-6 and cad1-3.	Zinc	95-97	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	153-159
29292464-8	2018	Subsequently, Zn2+ can cause the down-regulation of claudin-1, breakage of occludin and ZO-1 rings, and collapse of basolateral F-actin structures.	Zinc	14-18	claudin 1	Canis lupus familiaris	52-61
29403274-4	2018	Methods: A magnetic fluorescence-linked immunosorbent assay (FLISA) using CdSe/ZnS quantum dots as fluorescent probes was proposed for the rapid and sensitive detection of the DNMT1 level in this study.	Zinc	79-82	DNA methyltransferase 1	Homo sapiens	176-181
28801789-8	2018	Additionally, those human breast tissue samples were analyzed in parallel by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in order to gather additional information about the elemental distribution of Zn and its possible associations with MMPs.	Zinc	227-229	matrix metallopeptidase 11	Homo sapiens	265-269
29218630-5	2018	To investigate whether biological functions are reflected in molecular properties, we compare aspects of zinc(II)-binding dynamics of full-length MT4a and MT4b, namely the pH dependence of zinc(II) binding and protein folding, and zinc(II) transfer to the chelator EDTA.	Zinc	105-113	plant EC metallothionein family protein	Arabidopsis thaliana	146-150
29218630-9	2018	Non-conservative amino acid substitutions in this region affect local electrostatics as well as whole-domain dynamics, with both effects rendering zinc(II) ions bound to MT4a more reactive in metal transfer reactions.	Zinc	147-155	plant EC metallothionein family protein	Arabidopsis thaliana	170-174
29343155-12	2018	CONCLUSIONS: Our study showed that CMC-Zn2+-coated implants were effective in preventing pin tract infection.	Zinc	39-43	dynein light chain 1, cytoplasmic	Oryctolagus cuniculus	89-92
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	interferon gamma	Gallus gallus	134-143
29053834-1	2017	The aim of the study was to evaluate the effect of inorganic and organic forms of Zn on the expression of cytokines (IL-2, TNF-alpha, IFN-gamma, IL-12, IL-17, IL-4, IL-10, and TGF-beta) and immunoglobulins (IgA and IgG) in the tissues of the small intestine (jejunum and ileum) of broiler chickens.	Zinc	82-84	interleukin 17A	Gallus gallus	152-157
28841972-8	2017	The limits of detections (LODs) for Zn and Ca are 0.014-0.033 and 0.011-0.097mgL-1, respectively, which are in good agreement with the closed-type electrolyte cathode atmospheric glow discharge (ELCAD).	Zinc	36-38	LLGL scribble cell polarity complex component 1	Homo sapiens	77-82
28630041-0	2017	Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.	Zinc	13-17	transmembrane protein 109	Rattus norvegicus	76-89
28630041-5	2017	Cardiac SR vesicles prepared from sheep or mouse ventricular tissue were incorporated into phospholipid bilayers under voltage-clamp conditions, and the direct action of Zn2+ on RyR2 channel function was examined.	Zinc	170-174	ryanodine receptor 2, cardiac	Mus musculus	178-182
28774948-7	2017	We also found that DrHv1 is comparatively resistant to extracellular Zn2+, which is a potent inhibitor of mammalian Hv1, and this phenomenon appears to reflect variation in the Zn2+-coordinating residue (histidine) within the extracellular linker region in mammalian Hv1.	Zinc	177-181	hydrogen voltage-gated channel 1	Danio rerio	19-24
28750036-3	2017	To study the role of PDE1A in a mammalian system, we used a TALEN pair to Pde1a exon 7, targeting the histidine-aspartic acid dipeptide involved in ligating the active site Zn++ ion to generate two Pde1a null mouse lines.	Zinc	173-177	phosphodiesterase 1A	Homo sapiens	74-79
28696294-0	2017	TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles.	Zinc	41-45	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-5
28696294-5	2017	Treatments that increase reactive oxygen species (ROS) trigger TRPM7-dependent Zn2+ release from the vesicles, whereas reduced glutathione prevents TRPM7-dependent cytosolic Zn2+ influx.	Zinc	79-83	transient receptor potential cation channel subfamily M member 7	Homo sapiens	63-68
28696294-5	2017	Treatments that increase reactive oxygen species (ROS) trigger TRPM7-dependent Zn2+ release from the vesicles, whereas reduced glutathione prevents TRPM7-dependent cytosolic Zn2+ influx.	Zinc	174-178	transient receptor potential cation channel subfamily M member 7	Homo sapiens	148-153
28696294-6	2017	These observations strongly support the notion that ROS-mediated TRPM7 activation releases Zn2+ from intracellular vesicles after Zn2+ overload.	Zinc	91-95	transient receptor potential cation channel subfamily M member 7	Homo sapiens	65-70
28696294-6	2017	These observations strongly support the notion that ROS-mediated TRPM7 activation releases Zn2+ from intracellular vesicles after Zn2+ overload.	Zinc	130-134	transient receptor potential cation channel subfamily M member 7	Homo sapiens	65-70
28343244-3	2017	The probe showed high selectivity and sensitivity to Hg2+ over other metal ions such as Pb2+, Na+, K+, Cd2+, Cr3+, Zn2+, Cu2+, Ni2+, Ca2+, Fe3+, Fe2+, Co2+, Mn2+ and Mg2+ in MeCN/H2O (15/85, v/v).	Zinc	115-119	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	53-56
28592109-0	2017	Roles of the Active Site Zn(II) and Residues in Substrate Discrimination by Threonyl-tRNA Synthetase: An MD and QM/MM Investigation.	Zinc	25-27	threonyl-tRNA synthetase 1	Homo sapiens	76-100
28592109-1	2017	Threonyl-tRNA synthetase (ThrRS) is a Zn(II) containing enzyme that catalyzes the activation of threonine and its subsequent transfer to the cognate tRNA.	Zinc	38-44	threonyl-tRNA synthetase 1	Homo sapiens	0-24
28592109-1	2017	Threonyl-tRNA synthetase (ThrRS) is a Zn(II) containing enzyme that catalyzes the activation of threonine and its subsequent transfer to the cognate tRNA.	Zinc	38-44	threonyl-tRNA synthetase 1	Homo sapiens	26-31
28592109-3	2017	Molecular dynamics (MD) simulations and hybrid quantum mechanics/molecular mechanics (QM/MM) methods have been used to elucidate the role of Zn(II) in the aminoacylation mechanism of ThrRS.	Zinc	141-147	threonyl-tRNA synthetase 1	Homo sapiens	183-188
28592109-4	2017	More specifically, the role of Zn(II) and active site residues in ThrRS"s ability to discriminate between its cognate substrate l-threonine and the noncognate l-serine, l-valine, and d-threonine has been examined.	Zinc	31-33	threonyl-tRNA synthetase 1	Homo sapiens	66-71
28671251-6	2017	This motif is conserved in group bZIP and suggested to play a role as a Zn-sensor.	Zinc	72-74	basic leucine-zipper 8	Arabidopsis thaliana	33-37
28501617-4	2017	The binding of the RAPTA compounds to the BRCA1 protein resulted in a release of Zn2+ ions in a dose and time dependent manner, as well as thermal alteration of ruthenated-BRCA1 proteins.	Zinc	81-85	BRCA1 DNA repair associated	Homo sapiens	42-47
28483530-6	2017	Intriguingly, LAMP-2 knockdown further aggravated Zn2+-mediated ROS production and cell death, indicating LAMP-2 (not LAMP-1) was involved in Zn2+-induced toxicity.	Zinc	50-54	lysosomal associated membrane protein 2	Homo sapiens	106-112
28483530-6	2017	Intriguingly, LAMP-2 knockdown further aggravated Zn2+-mediated ROS production and cell death, indicating LAMP-2 (not LAMP-1) was involved in Zn2+-induced toxicity.	Zinc	142-146	lysosomal associated membrane protein 2	Homo sapiens	106-112
28483530-7	2017	Our results provide a new insight that LAMP-2 contributes to the ROS clearance and cell death induced by Zn2+ treatment, which would help us to get a better understanding of Zn2+-induced toxicity in respiratory system.	Zinc	105-109	lysosomal associated membrane protein 2	Homo sapiens	39-45
28483530-7	2017	Our results provide a new insight that LAMP-2 contributes to the ROS clearance and cell death induced by Zn2+ treatment, which would help us to get a better understanding of Zn2+-induced toxicity in respiratory system.	Zinc	174-178	lysosomal associated membrane protein 2	Homo sapiens	39-45
29745158-3	2017	Compared to elevation of the level of only Cd2+ or Zn2+, the seed germination rate under elevation of both Cd2+ and Zn2+ levels was enhanced significantly; O2-  generation rate, contents of H2O2 and MDA decreased; CAT, APX and MDAR activities increased in the last stage of Cd2+ and Zn2+ exposure.	Zinc	116-120	monodehydroascorbate reductase	Nicotiana tabacum	227-231
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	38-40	zinc transporter	Arabidopsis thaliana	121-125
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	90-92	zinc transporter	Arabidopsis thaliana	121-125
28859376-6	2017	Accessions with a higher tolerance to Zn deficiency showed an increased expression of the Zn deficiency-responsive genes ZIP4 and IRT3 in comparison with Zn deficiency-sensitive accessions.	Zinc	90-92	zinc transporter	Arabidopsis thaliana	121-125
28177192-2	2017	The O6 -MeG selectivity and MGMT inhibitory activity of DIGPor were improved by incorporating ZnII into the porphyrin.	Zinc	94-98	O-6-methylguanine-DNA methyltransferase	Homo sapiens	28-32
28316040-5	2017	According to the calculated Gibbs free energy, these three ranges correspond to the van der Waals attachment of Cl2 molecules on Zn-polar sites, van der Waals attachment of Cl2 molecules on O sites, and dissociation of Cl2 molecules on ZnO nanocrystal surfaces, respectively.	Zinc	129-131	endogenous retrovirus group W member 5	Homo sapiens	112-115
28194465-4	2017	The deletion of CKA2, the yeast orthologue of mammalian CK2alpha", leads to a pronounced resistant phenotype against Zn2+ and Al3+, whilst the deletion of CKB1 or CKB2 results in tolerance to Cr6+ and As3+.	Zinc	117-121	casein kinase 2 alpha 2	Homo sapiens	56-64
28096460-1	2017	The human dopamine transporter (DAT) has a tetrahedral Zn2+-binding site.	Zinc	55-59	solute carrier family 6 member 3	Homo sapiens	10-30
28096460-1	2017	The human dopamine transporter (DAT) has a tetrahedral Zn2+-binding site.	Zinc	55-59	solute carrier family 6 member 3	Homo sapiens	32-35
28257077-2	2017	This regulatory control from metals is observed in the relatively abundant plasma protein histidine-rich glycoprotein (HRG), which displays preferential binding to the second most abundant transition element in human systems, Zinc (Zn2+).	Zinc	232-236	histidine rich glycoprotein	Homo sapiens	119-122
28257077-5	2017	Changes in Zn2+ levels have been shown to modify HRG function by altering its affinity for certain ligands and/or providing protection against proteolytic disassembly by serine proteases.	Zinc	11-15	histidine rich glycoprotein	Homo sapiens	49-52
28257077-6	2017	This review focuses on the molecular interplay between HRG and Zn2+, and how Zn2+ binding modifies HRG-ligand interactions to regulate function in different settings of tissue injury.	Zinc	77-81	histidine rich glycoprotein	Homo sapiens	99-102
28071891-2	2017	Dual-enzyme-sensitive GEM nanovectors were prepared by conjugation of matrix metalloproteinase-9 (MMP-9) detachable poly(ethylene glycol) (PEG), cathepsin B-cleavable GEM, and targeting ligand CycloRGD to CdSe/ZnS quantum dots (QDs).	Zinc	210-213	matrix metallopeptidase 9	Homo sapiens	98-103
28112295-2	2017	In this work, we employed a DNA-directed covalent conjugation method to design a fluorescence probe for in vitro detection of functional matrix metalloproteinases, by which a nitrilotriacetic acid (NTA)-modified DNA probe can combine with the Zn2+ in the active site of MMPs, and then a molecule beacon (MB) modified FITC and BHQ1 can open to bond with their complementary base, NTA-modified DNA.	Zinc	243-247	matrix metallopeptidase 9	Homo sapiens	270-274
27722792-4	2017	Glutamate uptake inhibition by t-PDC (L-trans-pyrrolidine-2,4-dicarboxylic acid) or Zn2+-induced general mitochondrial dysfunction caused similar toxicity in WT and Ppt1 -/- cultures.	Zinc	84-88	palmitoyl-protein thioesterase 1	Mus musculus	165-169
28676853-6	2017	Furthermore, the upregulation of UQCRC1 reduced the concentration of free Zn2+ in mitochondria, whereas the downregulation of UQCRC1 increased the concentration of free Zn2+ in mitochondria.	Zinc	74-78	ubiquinol-cytochrome c reductase core protein 1	Rattus norvegicus	33-39
28676853-6	2017	Furthermore, the upregulation of UQCRC1 reduced the concentration of free Zn2+ in mitochondria, whereas the downregulation of UQCRC1 increased the concentration of free Zn2+ in mitochondria.	Zinc	169-173	ubiquinol-cytochrome c reductase core protein 1	Rattus norvegicus	126-132
27726084-11	2017	Of the total variance, 21.7 % was explained by factor 2 and had maximum loadings on Zn and Cd.	Zinc	84-86	transcription termination factor 2	Homo sapiens	47-55
28012153-6	2017	These conductive, biodegradable, and bioactive materials efficiently promoted neuroglial cell proliferation depending on the amount of Zn NPs present in the PCL matrix.	Zinc	135-137	PHD finger protein 1	Homo sapiens	157-160
28012153-7	2017	Chemical characterizations indicated that the incorporated Zn NPs do not interact with the PCL matrix chemically and that the Zn NPs improved the tensile properties of the PCL matrix.	Zinc	126-128	PHD finger protein 1	Homo sapiens	172-175
27791361-1	2016	A Zn-based metal-organic framework (MOF)/porous coordination polymer (PCP), (EMIM)[Zn(SIP)] (1) (SIP3- = 5-sulfoisophthalate, EMIM+ = 1-ethyl-3-methylimidazolium), was synthesized using the ionothermal reaction.	Zinc	2-4	gem nuclear organelle associated protein 7	Homo sapiens	97-101
27791361-3	2016	One of two carboxylates in SIP3- serves as a mu2-bridge ligand to link two Zn2+ ions and form the dinuclear SBU, and such SBUs are connected by SIP3- ligands to build the three-dimensional framework with rutile (rtl) topology.	Zinc	75-79	gem nuclear organelle associated protein 7	Homo sapiens	27-31
27694524-6	2016	In fact, the contribution of AtPCS1 to tolerating Zn excess is comparable with that of the major Zn tolerance factor MTP1.	Zinc	50-52	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	29-35
27694524-7	2016	For plants supplied with a normal level of Zn, a significant reduction in leaf Zn accumulation of AtPCS1 mutants was detected.	Zinc	43-45	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	98-104
27694524-7	2016	For plants supplied with a normal level of Zn, a significant reduction in leaf Zn accumulation of AtPCS1 mutants was detected.	Zinc	79-81	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	98-104
27694524-8	2016	In contrast, AtPCS1 mutants grown under Zn-limited conditions showed wild-type levels of Zn accumulation, suggesting the operation of distinct Zn translocation pathways.	Zinc	40-42	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	13-19
27665863-6	2016	Equilibria between equivalent ligands for one Zn(II) binding position have also been observed, the predominant site being made by the side chains of His6, His13 or His14, Glu11, and Asp1 or Glu3 or Asp7, with a slight preference for Asp1.	Zinc	46-52	beta-secretase 2	Homo sapiens	182-186
27665863-6	2016	Equilibria between equivalent ligands for one Zn(II) binding position have also been observed, the predominant site being made by the side chains of His6, His13 or His14, Glu11, and Asp1 or Glu3 or Asp7, with a slight preference for Asp1.	Zinc	46-52	beta-secretase 2	Homo sapiens	233-237
27567443-7	2016	Zn supplementation (IC50=15muM), increased significantly CDKN2A, pRB1 &amp; p53 and markedly reduced mdm2 expression; also protein expression levels of CDKN2A and pRb1 was significantly increased.	Zinc	0-2	MDM2 proto-oncogene	Homo sapiens	101-105
27334921-4	2016	The LECT2 structure adopts a conserved Zn(II) coordination configuration but lacks a proposed catalytic histidine residue, and its potential substrate-binding groove is blocked in the vicinity of the Zn(II)-binding site by an additional intrachain loop at the N terminus.	Zinc	39-45	leukocyte cell derived chemotaxin 2	Homo sapiens	4-9
27334921-4	2016	The LECT2 structure adopts a conserved Zn(II) coordination configuration but lacks a proposed catalytic histidine residue, and its potential substrate-binding groove is blocked in the vicinity of the Zn(II)-binding site by an additional intrachain loop at the N terminus.	Zinc	200-206	leukocyte cell derived chemotaxin 2	Homo sapiens	4-9
26514573-9	2016	From the adsorption of heavy metals and OM complex compounds contained in IPA 54 % on Fe-PILB, the bridging of humic acid between bentonite and heavy metals (Zn(II) or Cr(III)) is proposed as the dominant adsorption mechanism (bentonite-HA-Me).	Zinc	158-160	methionine sulfoxide reductase B2	Homo sapiens	89-93
26024288-3	2016	Peptidylamidoglycolate lyase is the PAM domain responsible for the Zn(II)-dependent dealkylation of the alpha-hydroxyglycine-containing precursor to the final alpha-amidated peptide.	Zinc	67-73	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	0-28
26024288-3	2016	Peptidylamidoglycolate lyase is the PAM domain responsible for the Zn(II)-dependent dealkylation of the alpha-hydroxyglycine-containing precursor to the final alpha-amidated peptide.	Zinc	67-73	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	36-39
27511040-14	2016	CONCLUSIONS: The concentration of 10(-4) mol/L Zn(2+) can significantly increase the expression of osteoblastic proteins such as ALP, BMP-2, RUNX2, Osterix and decrease the expression of RANKL in mice osteoblasts in TNF-alpha inflammatory environment.	Zinc	47-49	Sp7 transcription factor 7	Mus musculus	148-155
27031076-4	2016	These so-called VividZn proteins consist of two light-responsive Vivid domains that homodimerize upon illumination with blue light, thus preventing the binding of Zn(2+) between two Zn(2+) binding domains, Atox1 and WD4.	Zinc	21-23	antioxidant 1 copper chaperone	Homo sapiens	206-211
27031076-4	2016	These so-called VividZn proteins consist of two light-responsive Vivid domains that homodimerize upon illumination with blue light, thus preventing the binding of Zn(2+) between two Zn(2+) binding domains, Atox1 and WD4.	Zinc	163-165	antioxidant 1 copper chaperone	Homo sapiens	206-211
26637494-6	2016	Results showed that dietary supplementation of Zn reduced the gene expression of hypothalamic ghrelin and tumor necrosis factor alpha (TNF-alpha) (P &lt; 0.05).	Zinc	47-49	ghrelin/obestatin prepropeptide	Gallus gallus	94-101
27251638-3	2016	CD4(+) T helper cells are poised to be influenced by MT transduced zinc signaling because they produce intracellular reactive oxygen species following activation through the T cell receptor and are sensitive to small changes in intracellular [Zn(2+)].	Zinc	243-249	CD4 antigen	Mus musculus	0-3
26329999-9	2016	The expressions of apoptotic proteins caspase 12 and cleaved caspase 9 and caspase 3 were also significantly controlled in ZnS-NPs-treated primary MRPE cells when comparing with thapsigargin- and hydrogen peroxide-treated cells.	Zinc	123-126	caspase 3	Mus musculus	75-84
26886512-3	2016	Among the different approaches, which were developed for CXCR4 imaging, a CXCR4 antagonist biscyclam system (AMD3100, also called Mozobil), currently used in the clinic for the mobilization of hematopoietic stem cells, was radiolabeled with different radiometals such as (62)Zn, (64)Cu, (67)Ga, or (99m)Tc.	Zinc	275-277	C-X-C motif chemokine receptor 4	Homo sapiens	74-79
26845700-8	2016	RESULTS: Exposure to IL-17 and TNF-alpha enhanced expression of the Zn-importer ZIP-8, regardless of the concentration of Zn in the culture medium.	Zinc	68-70	interleukin 17A	Homo sapiens	21-26
26845700-11	2016	CONCLUSION: IL-17/TNF-mediated inflammation enhanced the intracellular Zn uptake by synoviocytes, further increasing inflammation.	Zinc	71-73	interleukin 17A	Homo sapiens	12-17
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Zinc	111-113	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	22-27
26610299-6	2016	Moreover, mutation of sod-2 or sod-3 gene encoding Mn-SOD increased susceptibility in nematodes exposed to Fe, Zn, or Ni, although Fe, Zn, or Ni at the examined concentration did not lead to toxicity in wild-type nematodes.	Zinc	135-137	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	22-27
26913170-3	2016	In this work, we present results from metal-binding studies and microbiology assays designed to ascertain whether Ca(II) ions modulate the Zn(II)-binding properties of S100A12 and further evaluate the antimicrobial properties of this protein.	Zinc	139-145	carbonic anhydrase 2	Homo sapiens	114-120
26913170-4	2016	Our metal depletion studies reveal that Ca(II) ions enhance the ability of S100A12 to sequester Zn(II) from microbial growth media.	Zinc	96-102	carbonic anhydrase 2	Homo sapiens	40-46
26913170-13	2016	Taken together, these data support a model whereby S100A12 uses Ca(II) ions to tune its Zn(II)-chelating properties and antimicrobial activity.	Zinc	88-94	carbonic anhydrase 2	Homo sapiens	64-70
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	212-218	brain derived neurotrophic factor	Homo sapiens	49-53
27007532-11	2016	The level of IL-10 was significantly lower in the Zn-H group by 60%, compared to the Zn-L group.	Zinc	50-52	interleukin 10	Homo sapiens	13-18
27007532-11	2016	The level of IL-10 was significantly lower in the Zn-H group by 60%, compared to the Zn-L group.	Zinc	85-87	interleukin 10	Homo sapiens	13-18
27073711-6	2016	We further demonstrate that PA and PI(3,5)P2 are also required for the ATP13A2-mediated protection against the toxic metals Mn(2+), Zn(2+), and Fe(3+), suggesting a general lipid-dependent activation mechanism of ATP13A2 in various PD-related stress conditions.	Zinc	132-134	ATPase cation transporting 13A2	Homo sapiens	71-78
26152878-1	2015	Nanometric size gold nanoparticles capped with thiotic acid are used to coordinate with the Zn (II) present in the catalytic center of Alcohol Dehydrogenase (ADH).	Zinc	92-99	aldo-keto reductase family 1 member A1	Homo sapiens	135-156
26152878-1	2015	Nanometric size gold nanoparticles capped with thiotic acid are used to coordinate with the Zn (II) present in the catalytic center of Alcohol Dehydrogenase (ADH).	Zinc	92-99	aldo-keto reductase family 1 member A1	Homo sapiens	158-161
26293594-1	2015	The zinc (Zn) transporter ZnT2 (SLC30A2) is expressed in specialized secretory cells including breast, pancreas and prostate, and imports Zn into mitochondria and vesicles.	Zinc	10-12	solute carrier family 30 member 2	Homo sapiens	26-30
26293594-1	2015	The zinc (Zn) transporter ZnT2 (SLC30A2) is expressed in specialized secretory cells including breast, pancreas and prostate, and imports Zn into mitochondria and vesicles.	Zinc	10-12	solute carrier family 30 member 2	Homo sapiens	32-39
26293594-2	2015	Mutations in SLC30A2 substantially reduce milk Zn concentration ([Zn]) and cause severe Zn deficiency in exclusively breastfed infants.	Zinc	47-49	solute carrier family 30 member 2	Homo sapiens	13-20
26293594-2	2015	Mutations in SLC30A2 substantially reduce milk Zn concentration ([Zn]) and cause severe Zn deficiency in exclusively breastfed infants.	Zinc	66-68	solute carrier family 30 member 2	Homo sapiens	13-20
26293594-4	2015	Here, we used breast milk [Zn] to identify novel non-synonymous ZnT2 variants in a population of lactating women.	Zinc	27-29	solute carrier family 30 member 2	Homo sapiens	64-68
26293594-11	2015	Compared with wild-type ZnT2, these variants were inappropriately localized, and most resulted in either "loss-of-function" or "gain-of-function", and altered sub-cellular Zn pools, Zn secretion, and cell cycle check-points.	Zinc	172-174	solute carrier family 30 member 2	Homo sapiens	24-28
26293594-12	2015	Our study indicates that SLC30A2 variants are common in this population, dysregulate Zn management and can lead to breast cell dysfunction.	Zinc	85-87	solute carrier family 30 member 2	Homo sapiens	25-32
26341213-8	2015	The substrate specificity of FeoE differs from that of FieF, the Escherichia coli homolog of FeoE, which has been reported to be a Cd(2+)/Zn(2+) or Fe(2+)/Zn(2+) exporter.	Zinc	138-140	cation diffusion facilitator family transporter	Shewanella oneidensis MR-1	55-59
26341213-8	2015	The substrate specificity of FeoE differs from that of FieF, the Escherichia coli homolog of FeoE, which has been reported to be a Cd(2+)/Zn(2+) or Fe(2+)/Zn(2+) exporter.	Zinc	155-157	cation diffusion facilitator family transporter	Shewanella oneidensis MR-1	55-59
26409900-5	2015	Comparison of the PRR1 of several mammalian species indicates the presence of a conserved binding site that might coordinate the Zn(2+) ion with an amino acid arrangement compatible with the cysteine-containing site that has been identified experimentally for rabbit HPRG.	Zinc	129-135	histidine rich glycoprotein	Homo sapiens	267-271
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	23-25	metallothionein 2	Danio rerio	103-106
26354112-7	2015	Exposure of embryos to Zn or the mixture exhibited up to 30-fold greater transcript abundances of MT1, MT2 and hsp70 compared to controls which is related to significant uptake of Zn from the sediment.	Zinc	180-182	metallothionein 2	Danio rerio	103-106
25854544-0	2015	Rice PCR1 influences grain weight and Zn accumulation in grains.	Zinc	38-40	cell number regulator 10	Oryza sativa Japonica Group	5-9
25854544-3	2015	Here, we found that plant cadmium resistance 1 (PCR1) influences both zinc (Zn) accumulation and grain weight in rice.	Zinc	76-78	cell number regulator 10	Oryza sativa Japonica Group	48-52
25854544-8	2015	Japonica-type PCR1 had a shorter N-terminus than did PCR1 in the other rice types, and yeast heterologously expressing japonica-type PCR1 was more sensitive to Zn than was yeast expressing indica-type PCR1.	Zinc	160-162	cell number regulator 10	Oryza sativa Japonica Group	14-18
26493598-6	2015	We then show that U87- p53 inactivity can be rescued by zinc (Zn).	Zinc	62-64	small nucleolar RNA, C/D box 87	Homo sapiens	18-21
26306426-4	2015	By monitoring root development under Zn-deficient conditions, we isolated a single mutant lacking the basic-region leucine-zipper transcription factor gene bZIP19.	Zinc	37-39	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	156-162
26395757-5	2015	Meanwhile, two different zincs inhibited the ZEA-induced loss of mitochondrial membrane potential and elevation of late-stage apoptosis via activating the mitochondrial apoptotic pathway by recovering the mRNA and protein expression of pro-apoptotic genes (Bax, Casp3, Casp9).	Zinc	25-30	BCL2-associated X protein	Mus musculus	257-260
26395757-5	2015	Meanwhile, two different zincs inhibited the ZEA-induced loss of mitochondrial membrane potential and elevation of late-stage apoptosis via activating the mitochondrial apoptotic pathway by recovering the mRNA and protein expression of pro-apoptotic genes (Bax, Casp3, Casp9).	Zinc	25-30	caspase 3	Mus musculus	262-267
26004220-4	2015	For instance, Mg(2+) and Zn(2+) favor the substitution at the Ca-5 site of beta-TCP while Sr(2+) and Ba(2+) tend to occupy Ca-3 and Ca-4 in the beta-type crystal structure.	Zinc	25-27	carbonic anhydrase 5A	Homo sapiens	62-66
25882556-9	2015	Our data supports a model in which the intracellular M3M4 domain senses high cytosolic Zn(2+) concentrations and regulates the plasma membrane levels of the hZIP4 transporter in response to Zn(2+) binding.	Zinc	190-196	solute carrier family 39 member 4	Homo sapiens	157-162
26148642-4	2015	The results show that volatile metals, such as Zn, Pb, Cu and Cd, were easily concentrated in the fine particles, especially in Dp2.5-1 and Dp1, with soluble and exchangeable substances as the main chemical species.	Zinc	47-49	Dodeca-satellite-binding protein 1	Drosophila melanogaster	140-143
26286729-7	2015	The miR-31 promoter in Zn-deficient esophagus was identified by ChIP-seq using an antibody for histone mark H3K4me3.	Zinc	23-25	microRNA 31	Rattus norvegicus	4-10
26286729-10	2015	RESULTS: In vivo, anti-miR-31 reduced miR-31 overexpression (P = .002) and suppressed the esophageal preneoplasia in Zn-deficient rats.	Zinc	117-119	microRNA 31	Rattus norvegicus	23-29
26286729-13	2015	In Zn-deficient esophagus, the miR-31 promoter region and NF-kappaBeta binding site were activated.	Zinc	3-5	microRNA 31	Rattus norvegicus	31-37
26044210-2	2015	Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn(2+) into CA1 pyramidal cells.	Zinc	33-35	carbonic anhydrase 1	Homo sapiens	59-62
26044210-2	2015	Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn(2+) into CA1 pyramidal cells.	Zinc	33-35	carbonic anhydrase 1	Homo sapiens	175-178
26044210-2	2015	Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn(2+) into CA1 pyramidal cells.	Zinc	163-165	carbonic anhydrase 1	Homo sapiens	59-62
26044210-2	2015	Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn(2+) into CA1 pyramidal cells.	Zinc	163-165	carbonic anhydrase 1	Homo sapiens	175-178
26051901-0	2015	Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II).	Zinc	80-86	egl-9 family hypoxia inducible factor 3	Homo sapiens	72-76
26051901-1	2015	We report herein that Zn(II) selectively inhibits the hypoxia-inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II).	Zinc	22-28	egl-9 family hypoxia inducible factor 3	Homo sapiens	98-102
25918859-9	2015	At a higher concentration, the mechanical properties of Zn and Mg doped HAP also depend significantly on impurity distribution between the Ca1 and Ca2 sites.	Zinc	56-58	carbonic anhydrase 1	Homo sapiens	139-142
25918859-9	2015	At a higher concentration, the mechanical properties of Zn and Mg doped HAP also depend significantly on impurity distribution between the Ca1 and Ca2 sites.	Zinc	56-58	carbonic anhydrase 2	Homo sapiens	147-150
25918859-10	2015	There is a strong evidence that Zn prefers Ca2 site for substituion whereas Mg has no such preference.	Zinc	32-34	carbonic anhydrase 2	Homo sapiens	43-46
26053888-0	2015	Investigation on Spin Dependent Transport Properties of Core-Shell Structural Fe3O4/ZnS Nanocomposites for Spintronic Application.	Zinc	84-87	spindlin 1	Homo sapiens	17-21
26053888-3	2015	Spin dependent electrical transport is studied on Fe3O4/ZnS nanocomposites with different shell thickness, and a large magnetoresistance (MR) ratio is observed under the magnetic field of 1.0 T at room temperature and 100 K for the compacted sample by Fe3O4/ZnS nanocomposites, which is 50% larger than that of sample with pure Fe3O4 particles, indicating that the enhanced MR is contributed from the spin injection between Fe3O4 and ZnS layer.	Zinc	56-59	spindlin 1	Homo sapiens	0-4
26053888-3	2015	Spin dependent electrical transport is studied on Fe3O4/ZnS nanocomposites with different shell thickness, and a large magnetoresistance (MR) ratio is observed under the magnetic field of 1.0 T at room temperature and 100 K for the compacted sample by Fe3O4/ZnS nanocomposites, which is 50% larger than that of sample with pure Fe3O4 particles, indicating that the enhanced MR is contributed from the spin injection between Fe3O4 and ZnS layer.	Zinc	258-261	spindlin 1	Homo sapiens	0-4
25794607-5	2015	Then, the rats were supplemented with Se and Zn at a concentration of 0.15 mgL(-1) and 227 mgL(-1), respectively, in drinking water for 3 weeks.	Zinc	45-47	LLGL scribble cell polarity complex component 1	Rattus norvegicus	75-81
25794607-5	2015	Then, the rats were supplemented with Se and Zn at a concentration of 0.15 mgL(-1) and 227 mgL(-1), respectively, in drinking water for 3 weeks.	Zinc	45-47	LLGL scribble cell polarity complex component 1	Rattus norvegicus	91-97
25892083-4	2015	Studies from the Jakob laboratory established that activation of the bacterial HSP33 upon its oxidation initiates by the release of pre-bound Zn from the well conserved Zn-binding motif Cys-X-Cys-Xn -Cys-X-X-Cys, and is followed by significant structural changes (Reichmann et al., ).	Zinc	142-144	uncharacterized protein	Chlamydomonas reinhardtii	79-84
25892083-4	2015	Studies from the Jakob laboratory established that activation of the bacterial HSP33 upon its oxidation initiates by the release of pre-bound Zn from the well conserved Zn-binding motif Cys-X-Cys-Xn -Cys-X-X-Cys, and is followed by significant structural changes (Reichmann et al., ).	Zinc	169-171	uncharacterized protein	Chlamydomonas reinhardtii	79-84
25915520-10	2015	As both VIM-2 and VIM-24 were inhibited in a similar manner, the crystal structure of a VIM-2-BTZ complex was determined at 1.25 A and revealed interactions of the inhibitor thiol with the VIM Zn center.	Zinc	193-195	VIM-2	Pseudomonas aeruginosa	8-13
25915520-10	2015	As both VIM-2 and VIM-24 were inhibited in a similar manner, the crystal structure of a VIM-2-BTZ complex was determined at 1.25 A and revealed interactions of the inhibitor thiol with the VIM Zn center.	Zinc	193-195	VIM-2	Pseudomonas aeruginosa	18-23
25586622-10	2015	Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group.	Zinc	97-99	kelch-like ECH-associated protein 1	Mus musculus	63-68
25586622-10	2015	Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group.	Zinc	97-99	NAD(P)H dehydrogenase, quinone 1	Mus musculus	74-78
25900096-5	2015	The involvement of ATP13A2 in Zn(2+) homeostasis has recently been demonstrated, with the molecular consequences of this disturbance causing lysosomal impairment, alpha-synuclein accumulation, and mitochondrial dysfunction.	Zinc	30-32	ATPase cation transporting 13A2	Homo sapiens	19-26
25923075-7	2015	In the present study, we found increased Ni accumulation in IRT1-null mutant under Zn deficiency in agar culture.	Zinc	83-85	iron-regulated transporter 1	Arabidopsis thaliana	60-64
25923075-8	2015	These suggest that Zn deficiency induces Ni accumulation in an IRT1-independen manner.	Zinc	19-21	iron-regulated transporter 1	Arabidopsis thaliana	63-67
25661177-5	2015	The Zn production process mainly contributed to oxidized Hg (Hg2+) emissions, whereas the waste disposal process generated mostly elemental Hg (Hg0) emissions.	Zinc	4-6	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	61-64
25549802-0	2015	Unusual Zn(II) Affinities of Zinc Fingers of Poly(ADP-ribose)Polymerase 1 (PARP-1) Nuclear Protein.	Zinc	8-10	regulating synaptic membrane exocytosis 2	Homo sapiens	83-98
25699459-1	2015	We report on the real space profile of spin polarons in the quasi-two-dimensional frustrated dimer spin system SrCu(2)(BO(3))(2) doped with 0.16% of Zn.	Zinc	149-151	spindlin 1	Homo sapiens	39-43
25699459-1	2015	We report on the real space profile of spin polarons in the quasi-two-dimensional frustrated dimer spin system SrCu(2)(BO(3))(2) doped with 0.16% of Zn.	Zinc	149-151	spindlin 1	Homo sapiens	99-103
25542361-2	2015	The phosphorescence of NAC-Mn: ZnS QDs is effectively quenched by Co(2+) attributing to the adsorption of Co(2+) onto the surface of QDs with a concomitant in suppressing the recombination process of hole and electron of QDs.	Zinc	31-34	X-linked Kx blood group	Homo sapiens	23-26
25542361-3	2015	The phosphorescence of Co(2+)-adsorbed NAC-Mn: ZnS QDs can be recovered by binding of Co(2+) with histidine.	Zinc	47-50	X-linked Kx blood group	Homo sapiens	39-42
25542361-7	2015	Co(2+)-adsorbed NAC-Mn: ZnS QDs show high sensitivity and good selectivity to histidine over other amino acids, metal ions and co-existing substances.	Zinc	24-27	X-linked Kx blood group	Homo sapiens	16-19
25832641-6	2015	In five out of the six ZFs (ZF1 to ZF5), Cys mutations that disrupt the ZF structure abolished response to Zn.	Zinc	107-109	zinc finger and BTB domain containing 14	Homo sapiens	35-38
25832641-7	2015	Of these, ZF5 was shown for the first time to be essential for Zn-responsive transcription, despite it being unnecessary for Zn-induced DNA binding.	Zinc	63-65	zinc finger and BTB domain containing 14	Homo sapiens	10-13
25530834-9	2015	Hammett plots show that the rds involves creation of a negative charge (interpreted as the loss of positive charge), supporting the notion that decomplexation of Zn(II) from the assemblies to generate apo-forms of 1 and 3 is rate-determining.	Zinc	162-165	peripherin 2	Homo sapiens	28-31
26521879-6	2015	We investigated the role of the two Zn(II) ions in IMP-1 by kinetic, spectroscopic and thermodynamic analyses.	Zinc	36-42	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	51-56
25326387-6	2014	We provide evidence that the 99-loop is responsible for two biochemical peculiarities of KLK2, i.e. reversible inhibition by micromolar Zn(2+) concentrations and permanent inactivation by autocatalytic cleavage.	Zinc	136-142	kallikrein related peptidase 2	Homo sapiens	89-93
25326387-7	2014	Indeed, several 99-loop mutants of KLK2 displayed an altered susceptibility to Zn(2+), which located the Zn(2+) binding site at the 99-loop/active site interface.	Zinc	79-81	kallikrein related peptidase 2	Homo sapiens	35-39
25326387-7	2014	Indeed, several 99-loop mutants of KLK2 displayed an altered susceptibility to Zn(2+), which located the Zn(2+) binding site at the 99-loop/active site interface.	Zinc	105-107	kallikrein related peptidase 2	Homo sapiens	35-39
25429618-5	2014	Time-lapse imaging revealed that TRPM2 deficiency had no effect on the ischemia-induced increase in the [Zn(2+)]c but abolished the cytosolic Zn(2+) accumulation during reperfusion as well as ROS-elicited increases in the [Zn(2+)]c. These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 pyramidal neuronal death and identify TRPM2 as a key molecule signaling ROS generation to postischemic brain injury.	Zinc	142-144	transient receptor potential cation channel subfamily M member 2	Homo sapiens	33-38
25409315-9	2014	Switching from Ca++-free to Ca++-enriched medium (1.8 mM) increased the dislodgement rate of claudin-1 as comparable quantitative delocalization was observed after only 6 h. Medium supplemented with the same concentration of Mg++ or Zn++ did not affect the dislodgement rate compared to the Ca++-free medium.	Zinc	233-237	claudin 1	Homo sapiens	93-102
25155653-4	2014	The wheel can be readily generated by mixing the tpy ligand and Zn(2+) in a stoichiometric ratio of 2:3; full characterization is provided by ESI-MS, NMR spectroscopy, and TEM imaging.	Zinc	64-70	MFT2	Homo sapiens	172-175
25054451-10	2014	Collectively, these results demonstrate that Mt3 may act through PDE3a to play a key role in Zn dyshomeostasis and cell death in STZ-treated islets.	Zinc	93-95	phosphodiesterase 3A, cGMP inhibited	Mus musculus	65-70
24907606-4	2014	Significant correlations existed between the ARGs and sediment properties as well as metals (Cu and Zn) and corresponding antibiotic classes, suggesting that the contamination of ARGs is related to chemical pollution of the sediments in the river basin.	Zinc	100-102	serpin family A member 2 (gene/pseudogene)	Homo sapiens	179-183
25105504-8	2014	We found that co-exposure to Zn2+ and Cd2+ synergistically enhanced RNA and protein expression of MT-1, MT-2, and the metal-regulatory transcription factor 1 in MDBK cells.	Zinc	29-33	metal regulatory transcription factor 1	Bos taurus	118-157
25022877-2	2014	Peptidylglycine alpha-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu and Zn, is the only enzyme that catalyzes this reaction.	Zinc	96-98	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	0-45
25022877-2	2014	Peptidylglycine alpha-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu and Zn, is the only enzyme that catalyzes this reaction.	Zinc	96-98	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	47-50
24829149-8	2014	Additionally, the inhibition of lysosomal exocytosis through knockdown (KD) of the lysosomal SNARE proteins VAMP7 and synaptotagmin VII (SYT7) suppressed Zn(2+) secretion and VAMP7 KD cells had increased apoptosis.	Zinc	154-156	vesicle associated membrane protein 7	Homo sapiens	108-113
24264723-12	2014	Importantly, Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells.	Zinc	13-19	S100 calcium binding protein A4	Homo sapiens	115-121
24334770-5	2014	Here, we found that patient fibroblasts expressing mutant PARK9 or primary neurons with silenced PARK9 exhibited increased sensitivity to extracellular zinc (Zn(2+)).	Zinc	158-160	ATPase cation transporting 13A2	Homo sapiens	58-63
24334770-5	2014	Here, we found that patient fibroblasts expressing mutant PARK9 or primary neurons with silenced PARK9 exhibited increased sensitivity to extracellular zinc (Zn(2+)).	Zinc	158-160	ATPase cation transporting 13A2	Homo sapiens	97-102
24334770-7	2014	PARK9-deficient cells showed decreased lysosomal sequestration of Zn(2+) and increased expression of zinc transporters.	Zinc	66-68	ATPase cation transporting 13A2	Homo sapiens	0-5
24334770-8	2014	Importantly, increased concentrations of Zn(2+) (Zn(2+) stress) resulted in lysosomal dysfunction that was partially restored by expression of wild-type PARK9.	Zinc	41-47	ATPase cation transporting 13A2	Homo sapiens	153-158
24334770-8	2014	Importantly, increased concentrations of Zn(2+) (Zn(2+) stress) resulted in lysosomal dysfunction that was partially restored by expression of wild-type PARK9.	Zinc	49-55	ATPase cation transporting 13A2	Homo sapiens	153-158
24334770-10	2014	Together, these data suggest that PARK9 loss of function leads to dyshomeostasis of intracellular Zn(2+) that in turn contributes to lysosomal dysfunction and accumulation of alpha-Syn.	Zinc	98-100	ATPase cation transporting 13A2	Homo sapiens	34-39
24399444-4	2014	Using patient-derived human olfactory neurosphere cultures, which harbour loss-of-function mutations in both alleles of ATP13A2, we identified a low intracellular free zinc ion concentration ([Zn(2+)]i), altered expression of zinc transporters and impaired sequestration of Zn(2+) into autophagy-lysosomal pathway-associated vesicles, indicating that zinc dyshomeostasis occurs in the setting of ATP13A2 deficiency.	Zinc	193-195	ATPase cation transporting 13A2	Homo sapiens	120-127
24399444-6	2014	The toxic effect of Zn(2+) was blocked by ATP13A2 overexpression, Zn(2+) chelation, antioxidant treatment and promotion of mitochondrial fusion.	Zinc	20-22	ATPase cation transporting 13A2	Homo sapiens	42-49
24399444-6	2014	The toxic effect of Zn(2+) was blocked by ATP13A2 overexpression, Zn(2+) chelation, antioxidant treatment and promotion of mitochondrial fusion.	Zinc	20-26	ATPase cation transporting 13A2	Homo sapiens	42-49
24771000-10	2014	MAIN RESULTS AND THE ROLE OF CHANCE: Intratubular cells of the germ line displayed a high redundancy of Zip family members involved in Zn uptake, while ZnT transporters were more represented in epididymis.	Zinc	135-137	death associated protein kinase 3	Homo sapiens	104-107
24832541-3	2014	We show that ZIF2 (Zinc-Induced Facilitator 2) localises primarily at the tonoplast of root cortical cells and is a functional transporter able to mediate Zn efflux when heterologously expressed in yeast.	Zinc	155-157	Major facilitator superfamily protein	Arabidopsis thaliana	13-17
24832541-4	2014	By affecting plant tissue partitioning of the metal ion, loss of ZIF2 function exacerbates plant sensitivity to excess Zn, while its overexpression enhances Zn tolerance.	Zinc	119-121	Major facilitator superfamily protein	Arabidopsis thaliana	65-69
24832541-6	2014	Importantly, high Zn favours production of the longer ZIF2.2 transcript, which compared to ZIF2.1 confers greater Zn tolerance to transgenic plants by promoting higher root Zn immobilization.	Zinc	18-20	Major facilitator superfamily protein	Arabidopsis thaliana	54-58
24832541-6	2014	Importantly, high Zn favours production of the longer ZIF2.2 transcript, which compared to ZIF2.1 confers greater Zn tolerance to transgenic plants by promoting higher root Zn immobilization.	Zinc	114-116	Major facilitator superfamily protein	Arabidopsis thaliana	54-58
24597671-6	2014	Zn supplement prevented the effects of TPEN and also increased Akt and GSK-3beta phosphorylation with a decrease in Nrf2 nuclear exporter, Fyn.	Zinc	0-2	Fyn proto-oncogene	Mus musculus	139-142
24597671-8	2014	Therefore, Zn up-regulates Nrf2 function via activating Akt-mediated inhibition of Fyn function.	Zinc	11-13	Fyn proto-oncogene	Mus musculus	83-86
24732911-7	2014	In contrast, Zn inhibited STAT3 activation through the up-regulation of SHP1 activity.	Zinc	13-15	nuclear receptor subfamily 0, group B, member 2	Mus musculus	72-76
24647953-3	2014	We showed previously that sublethal ischemia, which renders neurons transiently resistant to excitotoxic cell death, can also induce Zn(2+)-dependent changes in Kv2.1 localization and activation kinetics, suggesting that activity-dependent modifications of Kv2.1 may contribute to cellular adaptive responses to injury.	Zinc	133-135	potassium voltage-gated channel subfamily B member 1	Homo sapiens	161-166
24647953-3	2014	We showed previously that sublethal ischemia, which renders neurons transiently resistant to excitotoxic cell death, can also induce Zn(2+)-dependent changes in Kv2.1 localization and activation kinetics, suggesting that activity-dependent modifications of Kv2.1 may contribute to cellular adaptive responses to injury.	Zinc	133-135	potassium voltage-gated channel subfamily B member 1	Homo sapiens	257-262
24479872-7	2014	In contrast, the alpha domain retains a high capacity to bind Zn(2+) ions, and, consequently, the entire MT3 peptide shows a peculiar dual ability to handle both metal ions.	Zinc	62-68	metallothionein 3	Homo sapiens	105-108
24411595-8	2014	The C453A variant was shown to be a Zn(2+)-free enzyme with kinetic parameters similar to those of the truncated-ALP.	Zinc	36-42	PDZ and LIM domain 3	Homo sapiens	113-116
24433538-2	2014	ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter.	Zinc	50-52	Zap1p	Saccharomyces cerevisiae S288C	0-4
24433538-2	2014	ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter.	Zinc	104-106	Zap1p	Saccharomyces cerevisiae S288C	0-4
24581221-8	2014	Importantly, the metal-complex, ZnII(atsm), induced Zip7 upregulation, promoted Zn redistribution and restored Zn-dependent functions in primary mouse Cln6 deficient neurons and astrocytes.	Zinc	32-34	ceroid-lipofuscinosis, neuronal 6	Mus musculus	151-155
24575045-4	2014	The list of Panx1 activators includes extracellular ATP, glutamate, high K(+), Zn(2+), fibroblast growth factors (FGFs),pro-inflammatory cytokines, and elevation of intracellular Ca(2+).	Zinc	79-81	pannexin 1	Homo sapiens	12-17
24652391-0	2014	Dermcidin, an anionic antimicrobial peptide: influence of lipid charge, pH and Zn2+ on its interaction with a biomimetic membrane.	Zinc	79-83	dermcidin	Homo sapiens	0-9
24335702-5	2014	The compound, (6-amidoethyl)triphenylphosphonium Zinpyr-1 diacetate (DA-ZP1-TPP), is essentially nonfluorescent in the metal-free state; however, exposure to Zn(II) triggers metal-mediated hydrolysis of the acetyl groups to afford a large, rapid, and zinc-induced fluorescence response.	Zinc	158-164	zona pellucida glycoprotein 1	Homo sapiens	72-75
24343273-10	2014	Altogether, this study suggests that sub-toxic CuO-NP treatments induce successively a Cu overload, a Cu-Zn exchange on metallothioneins and MTF1 regulation on both Cu and Zn homeostasis.	Zinc	172-174	metal regulatory transcription factor 1	Equus caballus	141-145
24049181-5	2013	In this study, it was found that the interaction between JAB1 and Delta2 LHBS is facilitated by divalent metal Zn(2+) ions.	Zinc	111-113	COP9 signalosome subunit 5	Homo sapiens	57-61
24049181-6	2013	The binding of JAB1 to Delta2 LHBS requires the JAB1/CSN5 MPN metalloenzyme (JAMM) motif and residue H138 that binds to Zn(2+) ions in JAB1.	Zinc	120-122	COP9 signalosome subunit 5	Homo sapiens	15-19
24089197-3	2013	The body of collected experimental and theoretical data indicates that the monoanionic species binds Zn(ii) inducing a strong stabilization of the crystal-like arrangement of the central tartrate zinc-binding group, lending support for a two step TACE docking mechanism via a zinc-bound intermediate.	Zinc	101-107	ADAM metallopeptidase domain 17	Homo sapiens	247-251
23856622-4	2013	We demonstrate a dynamic role of divalent transition metal ions bound to site A: (i) Zn(2+) (or Co(2+)) in Metal A site changes coordination from octahedral to tetrahedral after the chemical step, which explains the known higher affinity of Tdt for the primer strand when these ions are present, and (ii) metal A has to leave to allow the translocation of the primer strand and to clear the active site, a typical feature for a ratchet-like mechanism.	Zinc	85-91	DNA nucleotidylexotransferase	Homo sapiens	241-244
24148476-1	2013	N-Acetyl-L-cysteine (NAC) and L-cysteine (Cys) capped Mn doped ZnS quantum dots (NAC-Mn/ZnS QDs and Cys-Mn/ZnS QDs) are firstly prepared by hydrothermal methods.	Zinc	63-66	X-linked Kx blood group	Homo sapiens	81-84
24141049-2	2013	Matrix metalloproteinase-2 (MMP-2), a Zn(2+)-dependent proteolytic enzyme, is involved in a wide variety of pathological and physiological pathways.	Zinc	38-44	matrix metallopeptidase 2	Mus musculus	0-26
24141049-2	2013	Matrix metalloproteinase-2 (MMP-2), a Zn(2+)-dependent proteolytic enzyme, is involved in a wide variety of pathological and physiological pathways.	Zinc	38-44	matrix metallopeptidase 2	Mus musculus	28-33
24138881-3	2013	We have found that GM-CSF-activated infected macrophages sequestered labile Zn by inducing binding to metallothioneins (MTs) in a STAT3 and STAT5 transcription-factor-dependent manner.	Zinc	76-78	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	19-25
24138881-4	2013	GM-CSF upregulated expression of Zn exporters, Slc30a4 and Slc30a7; the metal was shuttled away from phagosomes and into the Golgi apparatus.	Zinc	33-35	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
23860900-4	2013	hPLK activity is supported by several metals, being Zn(2+) the most effective, although the magnitude of the effect observed is highly dependent on the relative concentrations of metal and nucleotide used.	Zinc	52-54	polo like kinase 1	Homo sapiens	0-4
23962989-6	2013	The role of Zn in VEGF expression was tested in WT and MT3-KO cells treated with pyrithione, with or without additional Zn, using immunoblotting and fluorescence photomicrography.	Zinc	12-14	vascular endothelial growth factor A	Mus musculus	18-22
23962989-10	2013	Consistent with the possible involvement of Zn released from MT3, raising intracellular Zn levels increased VEGF levels and activated its receptor, Flk-1, in both WT and MT3-KO retinal cells.	Zinc	88-90	vascular endothelial growth factor A	Mus musculus	108-112
23962989-12	2013	Moreover, Zn released from MT3 may contribute to VEGF induction.	Zinc	10-12	vascular endothelial growth factor A	Mus musculus	49-53
23926594-0	2013	Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains.	Zinc	28-30	antioxidant 1 copper chaperone	Homo sapiens	51-55
23926594-1	2013	The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans.	Zinc	121-127	antioxidant 1 copper chaperone	Homo sapiens	28-32
23835914-5	2013	Zn(II) competition experiments with the metal ion chelator 4-(2-pyridylazo)resorcinol (PAR) in the presence of the cellular redox pair glutathione (GSH)/glutathione disulfide (GSSG) show that plant MTs from the subfamilies MT1, MT2, and MT3 are remarkably more affected by oxidative stress than those from the Ec subfamily and the well-characterized human MT2 form.	Zinc	0-6	metallothionein 3	Homo sapiens	237-240
23918396-0	2013	Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents.	Zinc	20-24	potassium voltage-gated channel subfamily B member 1	Homo sapiens	55-60
23918396-4	2013	We have reported that oxidant-induced intraneuronal Zn(2+) liberation triggers a syntaxin-dependent incorporation of Kv2.1 voltage-gated potassium channels into the plasma membrane.	Zinc	52-54	potassium voltage-gated channel subfamily B member 1	Homo sapiens	117-122
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Zinc	185-191	selenoprotein M	Homo sapiens	97-112
23652332-5	2013	Here, we reported that the His-rich domain of selenoprotein P (SelP-H) and the Sec-to-Cys mutant selenoprotein M (SelM") are capable of binding transition metal ions and modulating the Zn(2+)-mediated Abeta aggregation, ROS production and neurotoxicity.	Zinc	185-191	selenoprotein M	Homo sapiens	114-119
23652332-6	2013	SelM" (U48C) and SelP-H were found to coordinate 0.5 and 2 molar equivalents of Zn(2+)/Cd(2+) with micromolar and submicromolar affinities, respectively.	Zinc	80-82	selenoprotein M	Homo sapiens	0-5
23660814-3	2013	Keeping this view in mind, we performed molecular dynamics simulation of crystal structure complex of testis truncated version of ACE (tACE) and its inhibitor lisinopril along with Zn(2+) to understand the dynamic behavior of active site residues of tACE.	Zinc	181-183	ADAM metallopeptidase domain 17	Homo sapiens	250-254
23660814-7	2013	The residues Asp 7 and Ser 8 of Abeta-peptide were found in close contact with Glu 384 of tACE along with Zn(2+).	Zinc	106-108	ADAM metallopeptidase domain 17	Homo sapiens	90-94
23590825-6	2013	Certain members of the ZIP family (ZIP4, ZIP9, and ZIP12) showed significant induction in roots and shoots of the Zn- seedlings.	Zinc	114-116	zinc transporter	Arabidopsis thaliana	35-39
23590825-6	2013	Certain members of the ZIP family (ZIP4, ZIP9, and ZIP12) showed significant induction in roots and shoots of the Zn- seedlings.	Zinc	114-116	ZIP metal ion transporter family	Arabidopsis thaliana	41-45
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Zinc	64-66	iron-regulated transporter 1	Arabidopsis thaliana	56-60
23452087-5	2013	MDPT formed a stable complex with Zn(II) (log K = 10.84), which is 10(7) times more stable than the corresponding Ca(II) complex.	Zinc	34-40	carbonic anhydrase 2	Homo sapiens	114-120
23076326-1	2013	We previously reported the development of high affinity Zn(2+) FRET sensors based on the Zn(2+)-mediated interaction between the CXXC motifs present in the copper chaperone proteins ATOX1 and WD4.	Zinc	56-58	antioxidant 1 copper chaperone	Homo sapiens	182-187
23076326-1	2013	We previously reported the development of high affinity Zn(2+) FRET sensors based on the Zn(2+)-mediated interaction between the CXXC motifs present in the copper chaperone proteins ATOX1 and WD4.	Zinc	56-62	antioxidant 1 copper chaperone	Homo sapiens	182-187
23333209-1	2013	AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn(2+)-dependent, 27nM inhibitor of human plasma Lp-PLA(2).	Zinc	111-113	phospholipase A2 group VII	Homo sapiens	160-168
23274584-9	2013	Dietary or ZnT3-dependent Zn(2+) stores, and intracellular Zn(2+) release from rhodopsin recycling are suggested to be involved in light-induced retinal degeneration.	Zinc	26-32	solute carrier family 30 (zinc transporter), member 3	Mus musculus	11-15
23376504-7	2013	These results lead to the hypothesis that in aspartate buffer, Zn(2+) changes the conformation of oxytocin in such a way that the Cys(1,6) disulfide bridge is shielded from its environment thereby suppressing intermolecular reactions involving this region of the molecule.	Zinc	63-69	oxytocin/neurophysin I prepropeptide	Homo sapiens	98-106
23376504-8	2013	To verify this hypothesis, we investigate here the conformation of oxytocin in aspartate buffer in the presence of Mg(2+) or Zn(2+), using 2D NOESY, TOCSY, (1)H-(13)C HSQC and (1)H-(15)N HSQC NMR spectroscopy.	Zinc	125-127	oxytocin/neurophysin I prepropeptide	Homo sapiens	67-75
23376504-11	2013	Zn(2+) causes more extensive changes in oxytocin in aqueous solution than Mg(2+).	Zinc	0-2	oxytocin/neurophysin I prepropeptide	Homo sapiens	40-48
23086703-4	2013	Several compounds showed significant CXCR4 binding affinity, and zinc(II) complexation of bis(pyridin-2-ylmethyl)amine moieties resulted in a remarkable increase in CXCR4 binding affinity.	Zinc	65-73	C-X-C motif chemokine receptor 4	Homo sapiens	165-170
22890879-8	2012	Interestingly, Zn upregulated the expressions of VASA and ITG b1 but downregulated PIWIL2 and OCT4.	Zinc	15-17	piwi like RNA-mediated gene silencing 2	Homo sapiens	83-89
23064315-10	2012	The expression of miRNA 224 in 22Rv1 cell line was negatively correlated with             increasing zinc(II) concentration only.	Zinc	101-109	microRNA 224	Homo sapiens	18-27
23421216-3	2012	Furthermore, MnS/ZnS core/shell d-dots with a diffusion layer at the interface between the MnS core and the ZnS shell were fabricated through an overcoating of the ZnS shell layer on the presynthesized MnS core nanoclusters.	Zinc	17-20	glycophorin E (MNS blood group)	Homo sapiens	91-94
23421216-3	2012	Furthermore, MnS/ZnS core/shell d-dots with a diffusion layer at the interface between the MnS core and the ZnS shell were fabricated through an overcoating of the ZnS shell layer on the presynthesized MnS core nanoclusters.	Zinc	17-20	glycophorin E (MNS blood group)	Homo sapiens	91-94
23421216-3	2012	Furthermore, MnS/ZnS core/shell d-dots with a diffusion layer at the interface between the MnS core and the ZnS shell were fabricated through an overcoating of the ZnS shell layer on the presynthesized MnS core nanoclusters.	Zinc	108-111	glycophorin E (MNS blood group)	Homo sapiens	13-16
23421216-3	2012	Furthermore, MnS/ZnS core/shell d-dots with a diffusion layer at the interface between the MnS core and the ZnS shell were fabricated through an overcoating of the ZnS shell layer on the presynthesized MnS core nanoclusters.	Zinc	108-111	glycophorin E (MNS blood group)	Homo sapiens	13-16
22939141-7	2012	The electrode was tested on real samples (tap water spiked with Zn(2+), food supplement) with a good recovery by applying the standard addition method.	Zinc	64-70	nuclear RNA export factor 1	Homo sapiens	42-45
22332999-7	2012	These observations, supported by analysis of three-dimensional structures of TTR complexed with Zn2+, led to the hypothesis that TTR is a metallopeptidase.	Zinc	96-100	transthyretin	Homo sapiens	77-80
22332999-7	2012	These observations, supported by analysis of three-dimensional structures of TTR complexed with Zn2+, led to the hypothesis that TTR is a metallopeptidase.	Zinc	96-100	transthyretin	Homo sapiens	129-132
22332999-10	2012	The side chain of His88 is shifted near His90 and Glu92 establishing a Zn2+-chelating pattern HXHXE not found previously in any metallopeptidase and only conserved in TTR of humans and some other primates.	Zinc	71-75	transthyretin	Homo sapiens	167-170
22253018-4	2012	Surprisingly, we found that a BLM construct comprising only the two conserved RecA domains and the Zn(2+)-binding domain (residues 642-1077) can efficiently perform all mentioned HR-related activities.	Zinc	99-105	BLM RecQ like helicase	Homo sapiens	30-33
22436914-3	2012	HUT-11 contains two kinds of secondary building units (SBUs), Zn(3)(mu(3)-OH)(COO)(5) clusters and Zn(2)(COO)(4) clusters.	Zinc	62-64	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	0-6
22014117-6	2012	Detailed analysis showed clearly the correlation of AtMT4a and AtMT4b to the accumulation of some important metal ions in late embryos, especially to Zn ion storing in seeds, which then serves as part of early Zn ion resources for post-germinated seedling growth.	Zinc	150-152	plant EC metallothionein family protein	Arabidopsis thaliana	52-58
22014117-6	2012	Detailed analysis showed clearly the correlation of AtMT4a and AtMT4b to the accumulation of some important metal ions in late embryos, especially to Zn ion storing in seeds, which then serves as part of early Zn ion resources for post-germinated seedling growth.	Zinc	210-212	plant EC metallothionein family protein	Arabidopsis thaliana	52-58
22014117-7	2012	Furthermore, phytohormone abscisic acid (ABA) and gibberellic acid (GA) may play roles in regulating the expression and function of AtMT4a and AtMT4b during seed development; and this may influence Zn accumulation in seeds and Zn ion nutrient supplementation in the early seedling growth after germination.	Zinc	198-200	plant EC metallothionein family protein	Arabidopsis thaliana	132-138
22014117-7	2012	Furthermore, phytohormone abscisic acid (ABA) and gibberellic acid (GA) may play roles in regulating the expression and function of AtMT4a and AtMT4b during seed development; and this may influence Zn accumulation in seeds and Zn ion nutrient supplementation in the early seedling growth after germination.	Zinc	227-229	plant EC metallothionein family protein	Arabidopsis thaliana	132-138
22244776-3	2012	The enzyme activity analysis showed that FBP/SBPase can be activated by Mg2+ or Mn2+ but cannot be activated by Ca2+ or Zn2+.	Zinc	120-124	fructose-bisphosphatase 1	Homo sapiens	41-44
22244776-4	2012	Spectroscopic analysis of emission quenching showed that quenching mechanism of FBP/SBPase with Mg2+ or Mn2+ was static quenching mechanism while that of Ca2+ or Zn2+ was dynamic quenching process.	Zinc	162-166	fructose-bisphosphatase 1	Homo sapiens	80-83
22066515-9	2012	However, the phytochelatin-deficient mutant cad1-3 showed normal Fe-mediated Zn tolerance.	Zinc	77-79	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	44-48
22113110-1	2012	VanX, a Zn(II)-dependent D-ala-D-ala dipeptidase, is essential for vancomycin resistance in Enterococcus faecium.	Zinc	8-14	VanX protein	Enterococcus faecium	0-4
21603979-2	2012	Zn(2+) homeostasis in tissues is not only dependent on dietary intake but also on optimal expression and function of its influx (ZIP) and efflux (ZnT) transporters.	Zinc	0-2	death associated protein kinase 3	Homo sapiens	129-132
22120741-4	2011	The effect of Zn(2+) in increasing TTR L55P amyloidogenecity has been reported.	Zinc	14-16	transthyretin	Homo sapiens	35-38
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	35-37	metallothionein 3	Homo sapiens	74-77
21991581-1	2011	Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.	Zinc	133-139	metallothionein 3	Homo sapiens	74-77
21989461-3	2011	Changes in the morphology of the Zn(2)SnO(4) particles were studied by in situ scanning electron microscopy.	Zinc	33-35	strawberry notch homolog 2	Homo sapiens	38-41
20213444-13	2011	It forms complexes with Zn(2+) and, by chelating Zn(2+), S100A12 significantly inhibits MMPs.	Zinc	49-51	matrix metallopeptidase 9	Homo sapiens	88-92
20213444-14	2011	Zn(2+) in S100A12 complexes co-localize with MMP-9 in foam cells in atheroma.	Zinc	0-2	matrix metallopeptidase 9	Homo sapiens	45-50
21889053-6	2011	Presence of Zn(2+) and Cu(2+) in the assay medium inhibited the activity of the wall-associated malate dehydrogenase.	Zinc	12-14	LOC100856934	Zea mays	96-116
21889053-7	2011	Exposure of maize plants to excess concentrations of Zn(2+) and Cu(2+) in the hydroponic solution inhibited lateral root growth, decreased malate dehydrogenase activity and changed isoform profiles.	Zinc	53-55	LOC100856934	Zea mays	139-159
21872012-1	2011	This paper described an investigation of a novel eco-friendly fluorescence sensor for Hg(2+) ions based on N-acetyl-l-cysteine (NAC)-capped ZnS quantum dots (QDs) in aqueous solution.	Zinc	140-143	X-linked Kx blood group	Homo sapiens	128-131
21872012-2	2011	By using safe and low-cost materials, ZnS QDs modified by NAC were easily synthesized in aqueous medium via a one-step method.	Zinc	38-41	X-linked Kx blood group	Homo sapiens	58-61
21757718-1	2011	Histidine-rich glycoprotein (HRG) is an abundant protein that binds fibrinogen and other plasma proteins in a Zn(2+)-dependent fashion but whose function is unclear.	Zinc	110-112	histidine rich glycoprotein	Homo sapiens	0-27
21757718-1	2011	Histidine-rich glycoprotein (HRG) is an abundant protein that binds fibrinogen and other plasma proteins in a Zn(2+)-dependent fashion but whose function is unclear.	Zinc	110-112	histidine rich glycoprotein	Homo sapiens	29-32
21757718-4	2011	By immunoassay, HRG-fibrinogen complexes were detected in Zn(2+)-supplemented human plasma, a finding consistent with a high affinity interaction.	Zinc	58-64	histidine rich glycoprotein	Homo sapiens	16-19
21614444-3	2011	Treatments with Zn(CH(3)COO)(2) (50-350 muM) induced a dose-dependent ICAM-1 expression.	Zinc	16-18	intercellular adhesion molecule 1	Homo sapiens	70-76
21614444-4	2011	These results show that Zn(2+) alone is sufficient to induce similar levels of ICAM-1 expression as ZnO particles, suggesting that dissolved Zn(2+) may play the major role in inflammatory effect of ZnO particles on vascular endothelial cells.	Zinc	24-26	intercellular adhesion molecule 1	Homo sapiens	79-85
21668449-0	2011	SV31 is a Zn2+-binding synaptic vesicle protein.	Zinc	10-14	transmembrane protein 163	Rattus norvegicus	0-4
21668449-3	2011	Based on its amino acid sequence similarity to a prokaryotic heavy metal ion transporter we analyzed its metal ion-binding properties and show that recombinant SV31 binds the divalent cations Zn(2+) and Ni(2+) and to a minor extent Cu(2+), but not Fe(2+), Co(2+), Mn(2+), or Ca(2+).	Zinc	192-198	transmembrane protein 163	Rattus norvegicus	160-164
21687894-1	2011	The ZnO(0001)-Zn terminated crystal face was studied after reduction at high temperatures by combination of STM, STS, XPS and TDS.	Zinc	4-6	sulfotransferase family 1A member 3	Homo sapiens	108-111
21548881-3	2011	The hydrolysis of dUTP by DUT1 was strictly dependent on a bivalent metal cation with significant activity observed in the presence of Mg2+, Co2+, Mn2+, Ni2+ or Zn2+.	Zinc	161-165	bifunctional dITP/dUTP diphosphatase	Saccharomyces cerevisiae S288C	26-30
21914349-13	2011	Compared with the Ch group, rabbits of the Hm group demonstrated a marked reduction of aorta ET-1 expression, whereas Zn group had a significantly higher ET-1 expression.	Zinc	118-120	endothelin-1	Oryctolagus cuniculus	154-158
21354272-2	2011	To test a hypothesis that H(2)S might chelate and remove endogenous Zn(2+) that inhibits the Ca(v)3.2 isoform of T-type Ca(2+) channels, facilitating visceral nociception, we asked if intracolonic (i.col.)	Zinc	68-74	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	93-101
21354272-15	2011	Removal of luminal Zn(2+) by H(2)S and other Zn(2+) chelators thus produces colonic pain through activation of T-type Ca(2+) channels, most probably of the Ca(v)3.2 isoform.	Zinc	19-21	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	156-164
21354272-15	2011	Removal of luminal Zn(2+) by H(2)S and other Zn(2+) chelators thus produces colonic pain through activation of T-type Ca(2+) channels, most probably of the Ca(v)3.2 isoform.	Zinc	19-25	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	156-164
21304106-8	2011	HRG binds factor XIIa with high affinity, an interaction that is enhanced in the presence of Zn2(+), but does not bind factors XII, XI, or XIa.	Zinc	93-99	histidine rich glycoprotein	Homo sapiens	0-3
21304106-10	2011	These results suggest that, by binding to factor XIIa, HRG modulates the intrinsic pathway of coagulation, particularly in the vicinity of a thrombus where platelet release of HRG and Zn2(+) will promote this interaction.	Zinc	184-190	histidine rich glycoprotein	Homo sapiens	55-58
20978516-8	2011	Intracellular Zn(2+) accumulation in CA1 neurons, assessed using microinjection of FluoZin-3, showed significant increases following SD that was attributed to synaptic Zn(2+) release.	Zinc	14-20	carbonic anhydrase 1	Homo sapiens	37-40
20978516-8	2011	Intracellular Zn(2+) accumulation in CA1 neurons, assessed using microinjection of FluoZin-3, showed significant increases following SD that was attributed to synaptic Zn(2+) release.	Zinc	14-16	carbonic anhydrase 1	Homo sapiens	37-40
21219335-5	2011	In A. thaliana, lowering the expression of IRT1 and IRT2 through the addition of excess Fe to the medium increases Zn tolerance.	Zinc	115-117	iron-regulated transporter 1	Arabidopsis thaliana	43-47
21206042-6	2011	TBN1 contains three Zn2+ ions in a similar spatial arrangement to that observed in nuclease P1 from Penicillium citrinum.	Zinc	20-24	endonuclease precursor-like	Solanum lycopersicum	0-4
20524045-7	2010	Treatment with the antioxidant N-acetyl-L-cysteine (NAC) blunted the increase in Zn(2+) levels and reduced LC3-II conversion, cathepsin D release and cell death induced by tamoxifen.	Zinc	81-87	X-linked Kx blood group	Homo sapiens	52-55
20815365-0	2010	Structural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5.	Zinc	62-68	signal transducer and activator of transcription 2	Homo sapiens	82-86
21081802-18	2010	We concluded that 1) trace micronutrients such as Zn(2+) could be successfully measured in the gastric juice and gastric mucosa during ulcer healing; 2) compounds chelating of Zn(2+) can exert a beneficial influence on the ulcer healing via Zn(2+) mediated increase in gastric microcirculation, antisecretory activity and gastrin release, which may enhance the cell proliferation and differentiation during ulcer healing, ultimately exerting a trophic action on the ulcerated gastric mucosa.	Zinc	176-178	gastrin	Rattus norvegicus	322-329
21081802-18	2010	We concluded that 1) trace micronutrients such as Zn(2+) could be successfully measured in the gastric juice and gastric mucosa during ulcer healing; 2) compounds chelating of Zn(2+) can exert a beneficial influence on the ulcer healing via Zn(2+) mediated increase in gastric microcirculation, antisecretory activity and gastrin release, which may enhance the cell proliferation and differentiation during ulcer healing, ultimately exerting a trophic action on the ulcerated gastric mucosa.	Zinc	176-178	gastrin	Rattus norvegicus	322-329
20852107-6	2010	The absorption percentages of Zn as Zn Gly chelate, Zn Met chelate, Zn AA C, Zn Pro B, and Zn Pro A in the duodenum and jejunum were 29 to 129% higher (P&lt;0.05) than those of Zn as ZnSO4, Zn+Gly, and Zn+Met in the following order: Zn Pro A&gt;Zn Pro B&gt;Zn AA C&gt;Zn Gly chelate or Zn Met chelate&gt;ZnSO4, Zn+Met, or Zn+Gly.	Zinc	30-32	glycine-N-acyltransferase	Homo sapiens	260-264
20734993-3	2010	Though nonplanar and nonfluorescent, compound IC1 achieved pseudo planarity from binding with Zn(2+) as indicated by the increased fluorescence signal.	Zinc	94-100	ICR1 differentially methylated region	Homo sapiens	46-49
20701302-0	2010	Preparation of surface imprinting polymer capped Mn-doped ZnS quantum dots and their application for chemiluminescence detection of 4-nitrophenol in tap water.	Zinc	58-61	nuclear RNA export factor 1	Homo sapiens	149-152
20346586-2	2010	The resulting Zn(2)SnO(4) microcubes with the edge size ranging from 0.8 to 1.2 microm were composed of numerous nanoparticles with size of 10-20 nm, and their optical band gap energy was estimated to be 3.25 eV from the UV-vis diffuse reflectance spectra.	Zinc	14-16	strawberry notch homolog 2	Homo sapiens	19-22
20647347-9	2010	We propose that PCR2 functions as a Zn transporter essential for maintaining an optimal Zn level in Arabidopsis.	Zinc	36-38	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	16-20
20410362-9	2010	The current remaining showed decreased [Mg](o) affinities reminiscent of NR2C and NR2D subunits but was highly sensitive to [Zn](o), a potent NR2A blocker, showing a approximately 44.2 +/- 1.1% maximal inhibition at saturating concentrations with an IC(50) of 7.8 +/- 1.1 nM.	Zinc	125-127	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	Mus musculus	82-86
20428803-7	2010	FBL and CD164 were responsive to the treatment with Zn2+ in PNT2 prostate normal cells and were further overexpressed in the prolonged Zn2+-treated LNCaP cells.	Zinc	52-56	fibrillarin	Homo sapiens	0-3
20428803-7	2010	FBL and CD164 were responsive to the treatment with Zn2+ in PNT2 prostate normal cells and were further overexpressed in the prolonged Zn2+-treated LNCaP cells.	Zinc	135-139	fibrillarin	Homo sapiens	0-3
20428803-8	2010	These observations suggest that in general high Zn2+ has suppressive effects on prostate cancer cell growth but continuous exposure to an environment of high Zn2+ can lead to the overexpression of cancer promoting genes such as FBL and CD164.	Zinc	158-162	fibrillarin	Homo sapiens	228-231
20096995-3	2010	In neutral aqueous solutions, the PAR immobilized fiber responds selectively to heavy metal ions, such as Hg(2+), Pb(2+), Cd(2+), Zn(2+), Ni(2+) and Cu(2+) with a color change from red-orange to dark-brown.	Zinc	130-132	jumping translocation breakpoint	Homo sapiens	34-37
19415262-5	2010	In particular, as for the metal ion occupation configuration of the recombinant human prolidase, we have found that one of the two active sites is occupied by two Zn ions and the second one by one Zn and one Mn ion.	Zinc	163-165	peptidase D	Homo sapiens	86-95
19415262-5	2010	In particular, as for the metal ion occupation configuration of the recombinant human prolidase, we have found that one of the two active sites is occupied by two Zn ions and the second one by one Zn and one Mn ion.	Zinc	197-199	peptidase D	Homo sapiens	86-95
20129672-2	2010	Co(2+), Mn(2+), and Zn(2+) inhibited the arsenite methylation by hAS3MT in a concentration-dependent manner and the kinetics indicated Co(2+) and Mn(2+) to be mixed (competitive and non-competitive) inhibitors while Zn(2+) to be a competitive inhibitor.	Zinc	20-26	arsenite methyltransferase	Homo sapiens	65-71
20129672-2	2010	Co(2+), Mn(2+), and Zn(2+) inhibited the arsenite methylation by hAS3MT in a concentration-dependent manner and the kinetics indicated Co(2+) and Mn(2+) to be mixed (competitive and non-competitive) inhibitors while Zn(2+) to be a competitive inhibitor.	Zinc	216-222	arsenite methyltransferase	Homo sapiens	65-71
20208104-5	2010	It is revealed that the CdSe/ZnS QD bioconjugation to the antihuman Interleukin 10 antibodies is accompanied with the dramatic changes in the intensity of the Raman lines of both types: the intensity of the Si related line increases six- or ten-fold, but the intensity of the polymer related line decreases ten-fold.	Zinc	29-32	interleukin 10	Homo sapiens	68-82
19371353-1	2010	Our previous studies demonstrate alterations of zinc (Zn) transporter proteins ZnT-1, ZnT-4 and ZnT-6 in vulnerable brain regions of subjects with mild cognitive impairment (MCI), and early and late stage Alzheimer"s disease (AD), suggesting disruptions of Zn homeostasis may play a role in the pathogenesis of AD.	Zinc	54-56	solute carrier family 30 member 4	Homo sapiens	86-91
20037152-4	2010	We show here that intracellular Zn(2+) potently and reversibly activates large-conductance voltage- and Ca(2+)-activated Slo1 K(+) (BK) channels.	Zinc	32-38	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	121-125
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	14-20	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	31-35
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	14-20	transient receptor potential cation channel subfamily M member 7	Homo sapiens	87-92
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	14-20	transient receptor potential cation channel subfamily M member 7	Homo sapiens	94-135
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	70-76	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	31-35
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	70-76	transient receptor potential cation channel subfamily M member 7	Homo sapiens	87-92
20037152-7	2010	Extracellular Zn(2+) activated Slo1 BK channels when coexpressed with Zn(2+)-permeable TRPM7 (transient receptor potential melastatin 7) channels.	Zinc	70-76	transient receptor potential cation channel subfamily M member 7	Homo sapiens	94-135
20037152-8	2010	The results thus demonstrate that Slo1 BK channels represent a positive and direct effector of Zn(2+) signaling and may participate in sculpting cellular response to an increase in intracellular Zn(2+) concentration.	Zinc	95-98	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	34-38
20037152-8	2010	The results thus demonstrate that Slo1 BK channels represent a positive and direct effector of Zn(2+) signaling and may participate in sculpting cellular response to an increase in intracellular Zn(2+) concentration.	Zinc	95-101	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	34-38
19923004-0	2010	Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.	Zinc	13-17	sirtuin 1	Homo sapiens	94-99
19923004-2	2010	Herein we investigated the effects of Zn(2+) on the deacetylase activity of sirtuin 1 (silent mating type information regulation 2 homolog 1, SIRT1).	Zinc	38-40	sirtuin 1	Homo sapiens	76-140
19923004-3	2010	We found that the inherent Zn(2+) at the zinc-finger motif of SIRT1 is essential for the structural integrity and the deacetylase activity of SIRT1, whereas the exogenous Zn(2+) strongly inhibits the deacetylase activity with an IC(50) of 0.82muM for Zn(Gly)(2).	Zinc	27-29	sirtuin 1	Homo sapiens	62-67
19923004-3	2010	We found that the inherent Zn(2+) at the zinc-finger motif of SIRT1 is essential for the structural integrity and the deacetylase activity of SIRT1, whereas the exogenous Zn(2+) strongly inhibits the deacetylase activity with an IC(50) of 0.82muM for Zn(Gly)(2).	Zinc	27-29	sirtuin 1	Homo sapiens	142-147
19923004-3	2010	We found that the inherent Zn(2+) at the zinc-finger motif of SIRT1 is essential for the structural integrity and the deacetylase activity of SIRT1, whereas the exogenous Zn(2+) strongly inhibits the deacetylase activity with an IC(50) of 0.82muM for Zn(Gly)(2).	Zinc	171-173	sirtuin 1	Homo sapiens	62-67
19923004-3	2010	We found that the inherent Zn(2+) at the zinc-finger motif of SIRT1 is essential for the structural integrity and the deacetylase activity of SIRT1, whereas the exogenous Zn(2+) strongly inhibits the deacetylase activity with an IC(50) of 0.82muM for Zn(Gly)(2).	Zinc	171-173	sirtuin 1	Homo sapiens	142-147
19923004-4	2010	SIRT1 activity suppressed by the exogenous Zn(2+) can be fully recovered by the metal chelator EDTA but not by the activator resveratrol.	Zinc	43-45	sirtuin 1	Homo sapiens	0-5
19923004-6	2010	The 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence titration experiments and site-directed mutagenesis study suggested that the exogenous Zn(2+) binds to SIRT1 but not at the zinc-finger motif.	Zinc	147-149	sirtuin 1	Homo sapiens	163-168
19923004-7	2010	These results indicate that Zn(2+) plays a dual role in SIRT1 activity.	Zinc	28-34	sirtuin 1	Homo sapiens	56-61
19923004-9	2010	On the other hand, Zn(2+) may also bind to another site different from the zinc-finger motif or the binding sites for the substrates or resveratrol and act as a potent inhibitor of SIRT1.	Zinc	19-21	sirtuin 1	Homo sapiens	181-186
20352731-6	2010	Fluorescently labeled Tf was conjugated by the MeO-PEG-NTA with Cu2+ or Zn2+ coordination and injected intravenously into tumor-bearing mice.	Zinc	72-76	transferrin	Mus musculus	22-24
20352731-7	2010	The Tf conjugated with the MeO-PEG-NTA based on Cu2+ coordination was accumulated in the tumor site to a significantly great extent compared with the free Tf and Tf conjugated with the Zn2+ coordinated MeO-PEG-NTA.	Zinc	185-189	transferrin	Mus musculus	4-6
20352731-7	2010	The Tf conjugated with the MeO-PEG-NTA based on Cu2+ coordination was accumulated in the tumor site to a significantly great extent compared with the free Tf and Tf conjugated with the Zn2+ coordinated MeO-PEG-NTA.	Zinc	185-189	transferrin	Mus musculus	155-157
20352731-7	2010	The Tf conjugated with the MeO-PEG-NTA based on Cu2+ coordination was accumulated in the tumor site to a significantly great extent compared with the free Tf and Tf conjugated with the Zn2+ coordinated MeO-PEG-NTA.	Zinc	185-189	transferrin	Mus musculus	155-157
20050588-7	2010	The relative metal ion affinities of OT were found to be responsible for the relative effectiveness of divalent metal ions for the OT activation, which were in the order of Co(2+) &gt; Ni(2+) &gt; Mg(2+) &gt; Zn(2+), with a minimal effect by Ca(2+).	Zinc	209-211	oxytocin/neurophysin I prepropeptide	Homo sapiens	37-39
20050588-7	2010	The relative metal ion affinities of OT were found to be responsible for the relative effectiveness of divalent metal ions for the OT activation, which were in the order of Co(2+) &gt; Ni(2+) &gt; Mg(2+) &gt; Zn(2+), with a minimal effect by Ca(2+).	Zinc	209-211	oxytocin/neurophysin I prepropeptide	Homo sapiens	131-133
20921820-7	2010	The expressions of Cdkn1a, Bax, and Ccng, which are well known as radioresponsive genes, were upregulated in WBI mice and Zn-yeast treated WBI mice.	Zinc	122-124	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	19-25
20921820-7	2010	The expressions of Cdkn1a, Bax, and Ccng, which are well known as radioresponsive genes, were upregulated in WBI mice and Zn-yeast treated WBI mice.	Zinc	122-124	BCL2-associated X protein	Mus musculus	27-30
19928950-3	2009	In this report, we show how Zn(2+) rapidly and reversibly decreases the water permeability of AQP4 when it is reconstituted into proteoliposomes.	Zinc	28-30	aquaporin 4	Homo sapiens	94-98
19928950-6	2009	These results suggest that the water permeability of AQP4 may be regulated by dynamic changes in intracellular Zn(2+) concentration linked to the cellular redox state.	Zinc	111-117	aquaporin 4	Homo sapiens	53-57
19786305-0	2009	Probing the Cu(2+) and Zn(2+) binding affinity of histidine-rich glycoprotein.	Zinc	23-29	histidine rich glycoprotein	Homo sapiens	50-77
19963161-9	2009	In Ca-deficient rats, ITF increased liver (Fe and Zn) and tibia (Zn) mineral levels but impaired tibia Mg, yield load, and resilience.	Zinc	50-52	trefoil factor 3	Rattus norvegicus	22-25
19963161-9	2009	In Ca-deficient rats, ITF increased liver (Fe and Zn) and tibia (Zn) mineral levels but impaired tibia Mg, yield load, and resilience.	Zinc	65-67	trefoil factor 3	Rattus norvegicus	22-25
19903770-7	2009	Relesate from in vitro-activated platelets promoted binding of the His/Pro-rich domain of HRG to endothelial cells, an effect mediated by Zn(2+).	Zinc	138-140	histidine rich glycoprotein	Homo sapiens	90-93
19712047-11	2009	Furthermore, the presence of heparin, Zn2+ or acidic pH was found to protect HRG from plasmin cleavage.	Zinc	38-42	histidine rich glycoprotein	Homo sapiens	77-80
19710230-1	2009	Selenium-Binding Protein1 (SBP1) gene expression was studied in Arabidopsis (Arabidopsis thaliana) seedlings challenged with several stresses, including cadmium (Cd), selenium {selenate [Se(VI)] and selenite [Se(IV)]}, copper (Cu), zinc (Zn), and hydrogen peroxide (H(2)O(2)) using transgenic lines expressing the luciferase (LUC) reporter gene under the control of the SBP1 promoter.	Zinc	238-240	selenium-binding protein 1	Arabidopsis thaliana	27-31
19622611-1	2009	Oxidant-liberated intracellular Zn(2+) regulates neuronal apoptosis via an exocytotic membrane insertion of Kv2.1-encoded ion channels, resulting in an enhancement of voltage-gated K(+) currents and a loss of intracellular K(+) that is necessary for caspase-mediated proteolysis.	Zinc	32-34	potassium voltage-gated channel subfamily B member 1	Homo sapiens	108-113
19622611-6	2009	Kv2.1-encoded channels thus regulate neuronal survival by providing a converging input for two Zn(2+)-dependent signal transduction cascades.	Zinc	95-101	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
19634909-5	2009	ZinCleav-1 has a K(d) of 0.23 pM for Zn(2+) as measured by competitive titration with [Zn(PAR)(2)] (PAR = 4-(2-pyridyl-2-azo) resorcinol).	Zinc	37-43	jumping translocation breakpoint	Homo sapiens	90-93
19634909-5	2009	ZinCleav-1 has a K(d) of 0.23 pM for Zn(2+) as measured by competitive titration with [Zn(PAR)(2)] (PAR = 4-(2-pyridyl-2-azo) resorcinol).	Zinc	37-39	jumping translocation breakpoint	Homo sapiens	90-93
19624124-0	2009	Homodimerization and heterodimerization of minimal zinc(II)-binding-domain peptides of T-cell proteins CD4, CD8alpha, and Lck.	Zinc	51-59	CD8a molecule	Homo sapiens	108-116
19425569-0	2009	Effects of Zn(2+), Ca(2+), and Mg(2+) on the structure of Zn(7)metallothionein-3: evidence for an additional zinc binding site.	Zinc	11-17	metallothionein 3	Homo sapiens	63-80
19425569-0	2009	Effects of Zn(2+), Ca(2+), and Mg(2+) on the structure of Zn(7)metallothionein-3: evidence for an additional zinc binding site.	Zinc	11-13	metallothionein 3	Homo sapiens	63-80
19425569-1	2009	Human metallothionein-3 (Zn(7)MT-3), an intra- and extracellularly occurring metalloprotein, is highly expressed in the brain, where it plays an important role in the homeostasis of the essential metal ions Cu(+) and Zn(2+).	Zinc	25-27	metallothionein 3	Homo sapiens	6-23
19369217-7	2009	Our results broaden our knowledge on how three important functions of Vif (RNA binding, RT binding and stimulation and Zn(++) binding), are coordinated by different domains.	Zinc	119-125	Vif	Human immunodeficiency virus 1	70-73
19321442-1	2009	Oxygen and glucose deprivation (OGD) induces delayed cell death in hippocampal CA1 neurons via Ca(2+)/Zn(2+)-permeable, GluR2-lacking AMPA receptors (AMPARs).	Zinc	102-108	carbonic anhydrase 1	Homo sapiens	79-82
19018666-9	2009	The high affinity shows that metallation of Cox17(0S-S) by Zn(II) might be significant in cellular conditions, which might protect Cox17 from oxidation and enable its transport into IMS.	Zinc	59-65	cytochrome c oxidase copper chaperone COX17	Homo sapiens	131-136
19282477-5	2009	The latter domain corresponds to the NS3 serine protease domain and contains a structural Zn(2+)-binding site with functional importance for both viral proteases.	Zinc	90-96	KRAS proto-oncogene, GTPase	Homo sapiens	37-40
19282477-8	2009	Basal activity could be dramatically enhanced by the NS3 Zn(2+)-binding domain (NS3 amino acids 81-213) not only in cis but also in trans which, however, required a more extended N-terminal part of NS3 downstream of NS2 in cis.	Zinc	57-63	KRAS proto-oncogene, GTPase	Homo sapiens	53-56
19282477-8	2009	Basal activity could be dramatically enhanced by the NS3 Zn(2+)-binding domain (NS3 amino acids 81-213) not only in cis but also in trans which, however, required a more extended N-terminal part of NS3 downstream of NS2 in cis.	Zinc	57-63	KRAS proto-oncogene, GTPase	Homo sapiens	80-83
19282477-8	2009	Basal activity could be dramatically enhanced by the NS3 Zn(2+)-binding domain (NS3 amino acids 81-213) not only in cis but also in trans which, however, required a more extended N-terminal part of NS3 downstream of NS2 in cis.	Zinc	57-63	KRAS proto-oncogene, GTPase	Homo sapiens	80-83
20596475-5	2009	The 1D CdS@ZnS core-shell nanocomposites were confirmed by XRD, SEM, TEM, HR-TEM, ED, and EDS techniques.	Zinc	11-14	MFT2	Homo sapiens	69-72
19148713-7	2009	An elevation of [Zn(2+)](i) mediates mRNA expression of metallothionein and the peripheral benzodiazepine receptor (PBR) induced by hypoosmotic astrocyte swelling.	Zinc	17-23	translocator protein	Rattus norvegicus	80-114
19148713-7	2009	An elevation of [Zn(2+)](i) mediates mRNA expression of metallothionein and the peripheral benzodiazepine receptor (PBR) induced by hypoosmotic astrocyte swelling.	Zinc	17-23	translocator protein	Rattus norvegicus	116-119
19445235-8	2009	It is suggested that the content of Zn and the Na/K ratio may be involved in the resistance response to pathogen invasion and the development of antisense ACS transgenic tomato fruit.	Zinc	36-38	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	155-158
19000913-4	2009	Inhibition or stimulation was lost in a DAT construct without the binding site for Zn(2+).	Zinc	83-85	solute carrier family 6 member 3	Homo sapiens	40-43
19000913-5	2009	Also reverse transport was differentially affected by Zn(2+), dependent on whether the DAT was expressed in HEK293 or SK-N-MC cells.	Zinc	54-56	solute carrier family 6 member 3	Homo sapiens	87-90
19000913-6	2009	Pre-treatment of DAT expressing cells with phorbol-12-myristate-13-acetate, an activator of protein kinase C, attenuated the inhibitory effect of Zn(2+) on uptake in HEK293 cells and increased the stimulatory effect in SK-N-MC cells.	Zinc	146-148	solute carrier family 6 member 3	Homo sapiens	17-20
19000913-9	2009	This study represents the first evidence that DAT regulation by Zn(2+) is profoundly modulated by the membrane potential and chloride.	Zinc	64-70	solute carrier family 6 member 3	Homo sapiens	46-49
19071938-0	2008	Adsorption/desorption of H2 and CO on Zn-modified Pd(111).	Zinc	38-40	relaxin 2	Homo sapiens	25-34
19137815-4	2008	In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.	Zinc	117-121	matrix metallopeptidase 9	Homo sapiens	78-83
19256393-8	2008	The categories of industrial plants play the most important role in separating the high and low level of Zn concentration (G1, G2 and G3, G4, G5), and the pH value, soil types and agricultural types play important roles in differentiation among G1 and G2, and among G3, G4 and G5.	Zinc	105-107	serine/threonine kinase 19	Homo sapiens	123-144
19113375-2	2008	The 2D frozen spin-disordered state of NiGa2S4 is stable against the substitution of Zn2+ (S=0) and Heisenberg Fe2+ (S=2) spins, and exhibits a T2-dependent magnetic specific heat, scaled by the Weiss temperature.	Zinc	85-89	spindlin 1	Homo sapiens	14-18
18959744-2	2008	PrP binds glycosaminoglycan (GAG) and divalent cations, such as Cu(2+) and Zn(2+).	Zinc	75-77	proline rich protein 2-like 1	Rattus norvegicus	0-3
18940611-2	2008	Through X-ray crystallography, we solved the structures of Ca(2+)-free and -bound forms of N-terminally truncated human ALG-2 (des3-20ALG-2), Zn(2+)-bound form of full-length ALG-2, and the structure of the complex between des3-23ALG-2 and the peptide corresponding to Alix799-814 in Zn(2+)-bound form.	Zinc	284-286	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	120-125
18782483-6	2008	The LVA-LZ group tended to show decreased amounts of the BDNF and NGF, while animals supplemented with high vitamin A along with Zn deficiency had high BDNF and NGF concentrations.	Zinc	129-131	nerve growth factor	Mus musculus	161-164
18583042-8	2008	Copper (Cu(2+), 50-100 microM) and manganese (Mn(2+), 50-100 microM) potently increased the expression of both APP and BACE1 in a time- and concentration-dependent pattern, while zinc (Zn(2+)), iron (Fe(2+)) and aluminum (Al(3+)) did not.	Zinc	185-187	beta-secretase 1	Rattus norvegicus	119-124
18593588-9	2008	Considering that Zn(2+) is synaptically co-released with glutamate from mossy fiber terminals that make excitatory synapses onto CA3 neurons, these results suggest that endogenous Zn(2+) modulation of these glycine receptors may have an important role in the excitability of CA3 neurons.	Zinc	17-23	carbonic anhydrase 3	Rattus norvegicus	129-132
18593588-9	2008	Considering that Zn(2+) is synaptically co-released with glutamate from mossy fiber terminals that make excitatory synapses onto CA3 neurons, these results suggest that endogenous Zn(2+) modulation of these glycine receptors may have an important role in the excitability of CA3 neurons.	Zinc	17-23	carbonic anhydrase 3	Rattus norvegicus	275-278
18593588-9	2008	Considering that Zn(2+) is synaptically co-released with glutamate from mossy fiber terminals that make excitatory synapses onto CA3 neurons, these results suggest that endogenous Zn(2+) modulation of these glycine receptors may have an important role in the excitability of CA3 neurons.	Zinc	180-186	carbonic anhydrase 3	Rattus norvegicus	129-132
18593588-9	2008	Considering that Zn(2+) is synaptically co-released with glutamate from mossy fiber terminals that make excitatory synapses onto CA3 neurons, these results suggest that endogenous Zn(2+) modulation of these glycine receptors may have an important role in the excitability of CA3 neurons.	Zinc	180-186	carbonic anhydrase 3	Rattus norvegicus	275-278
18357523-4	2008	Namely, we have concluded that: (1) the Kv4 channel complex employs novel alternative mechanisms of closed-state inactivation; (2) the intracellular Zn(2+) site in the T1 domain undergoes a conformational change tightly coupled to voltage-dependent gating and is targeted by nitrosative modulation; and (3) discrete and specific interactions mediate the effects of KChIPs and DPLPs on activation, inactivation and permeation of Kv4 channels.	Zinc	149-151	potassium voltage-gated channel subfamily C member 1	Homo sapiens	40-43
18357523-4	2008	Namely, we have concluded that: (1) the Kv4 channel complex employs novel alternative mechanisms of closed-state inactivation; (2) the intracellular Zn(2+) site in the T1 domain undergoes a conformational change tightly coupled to voltage-dependent gating and is targeted by nitrosative modulation; and (3) discrete and specific interactions mediate the effects of KChIPs and DPLPs on activation, inactivation and permeation of Kv4 channels.	Zinc	149-151	potassium voltage-gated channel subfamily C member 1	Homo sapiens	428-431
18563879-5	2008	In the initial step binding of MX2 to a bridging thiolate in [Zn4(SPh)10](2-) results in breaking of a Zn-bridging thiolate bond.	Zinc	62-64	MX dynamin like GTPase 2	Homo sapiens	31-34
18596163-0	2008	Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.	Zinc	192-196	immunoglobulin binding protein 1	Homo sapiens	117-123
18596163-0	2008	Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.	Zinc	192-196	immunoglobulin binding protein 1	Homo sapiens	152-158
18596163-4	2008	We show that Zn2+ exerts an inhibitory modulatory effect on (alpha4)(2)(beta2)(3) receptors, whereas it potentiates or inhibits, depending on its concentration, the function of (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	immunoglobulin binding protein 1	Homo sapiens	61-67
18596163-4	2008	We show that Zn2+ exerts an inhibitory modulatory effect on (alpha4)(2)(beta2)(3) receptors, whereas it potentiates or inhibits, depending on its concentration, the function of (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	immunoglobulin binding protein 1	Homo sapiens	178-184
18596163-5	2008	Furthermore, Zn2+ inhibition on (alpha4)(2)(beta2)(3) nAChRs is voltage-dependent, whereas it is not on (alpha4)(3)(beta2)(2) receptors.	Zinc	13-17	immunoglobulin binding protein 1	Homo sapiens	33-39
18596163-7	2008	Zn(2+) inhibition is mediated by a site located on the beta2(+)/alpha4(-) subunit interfaces on both receptor stoichiometries.	Zinc	0-2	immunoglobulin binding protein 1	Homo sapiens	64-70
18596163-9	2008	Zn2+ potentiation on (alpha4)(3)(beta2)(2) nAChRs is exerted by a site that resides on the alpha4(+)/alpha4(-) of this receptor stoichiometry.	Zinc	0-4	immunoglobulin binding protein 1	Homo sapiens	22-28
18596163-9	2008	Zn2+ potentiation on (alpha4)(3)(beta2)(2) nAChRs is exerted by a site that resides on the alpha4(+)/alpha4(-) of this receptor stoichiometry.	Zinc	0-4	immunoglobulin binding protein 1	Homo sapiens	91-97
18596163-9	2008	Zn2+ potentiation on (alpha4)(3)(beta2)(2) nAChRs is exerted by a site that resides on the alpha4(+)/alpha4(-) of this receptor stoichiometry.	Zinc	0-4	immunoglobulin binding protein 1	Homo sapiens	91-97
18596163-11	2008	We also identified residues within the beta2 subunit that confer voltage dependency to Zn2+ inhibition on (alpha4)(2)(beta2)(3), but not on (alpha4)(3)(beta2)(2) nAChRs.	Zinc	87-91	immunoglobulin binding protein 1	Homo sapiens	107-113
18569014-5	2008	Infusion of Abeta(1-40) led to an increase in Mn-superoxide dismutase activity and a decrease in activities of catalase and glutathione peroxidase in mitochondria, to elevation of activities of Cu,Zn-superoxide dismutase and aldehyde oxidase, forwarded the conversion of xanthine dehydrogenase to xanthine oxidase and corresponding increase in the rate of H2O2 formation in the cytosol.	Zinc	197-199	amyloid beta precursor protein	Rattus norvegicus	12-17
18393501-6	2008	MD and DFT calculations also indicate either an octahedral or trigonal-bipyramidal complex between Zn(2+) and OT is lowest in energy with carbonyl oxygens being the primary ligation sites.	Zinc	99-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	110-112
17566863-5	2008	The samples from IS1, IS2, and IS3, located in the Talcahuano industrial park, had higher Cr, Ni, Pb, and Zn contents than did samples from the other sites.	Zinc	106-108	IS1	Homo sapiens	17-20
18327593-0	2008	Overexpression of AtMHX in tobacco causes increased sensitivity to Mg2+, Zn2+, and Cd2+ ions, induction of V-ATPase expression, and a reduction in plant size.	Zinc	73-77	magnesium/proton exchanger	Arabidopsis thaliana	18-23
18327593-7	2008	This suggested that AtMHX can carry in planta not only Mg(2+) and Zn(2+) ions, as previously deduced based on observations in tissue-culture, but also Cd(2+) ions.	Zinc	66-72	magnesium/proton exchanger	Arabidopsis thaliana	20-25
18491323-10	2008	PKC alpha was significantly decreased in Zn deficiency suggesting that Zn may regulate the phosphorylation of target proteins.	Zinc	41-43	protein kinase C, alpha	Rattus norvegicus	0-9
18491323-10	2008	PKC alpha was significantly decreased in Zn deficiency suggesting that Zn may regulate the phosphorylation of target proteins.	Zinc	71-73	protein kinase C, alpha	Rattus norvegicus	0-9
18261461-1	2008	The divalent cations Mg(2+), Mn(2+), Zn(2+), Ca(2+), and Ni(2+) were found to protect against proteolysis a form of GroEL (ox-GroEL) prepared by exposing GroEL for 16h to 6mM hydrogen peroxide (H(2)O(2)).	Zinc	37-42	heat shock protein family D (Hsp60) member 1	Homo sapiens	126-131
17590860-6	2008	It was also shown that additional MT-1 mRNAs were expressed when the cells were exposed to either metal; MT-1A, MT-1F, MT-G and MT-1H for Cd(+2)-exposed cells; and, MT-1F, MT-G and MT-1H for Zn(+2)-exposed cells.	Zinc	191-193	metallothionein 1F	Homo sapiens	165-170
18287311-0	2008	Supplementation of growth media with Zn2+ facilitates detection of VIM-2-producing Pseudomonas aeruginosa.	Zinc	37-41	VIM-2	Pseudomonas aeruginosa	67-72
18287486-5	2008	The type-4 MTs (MT4a and MT4b) conferred greater Zn tolerance and higher accumulation of Zn than other MTs to the Deltazrc1 Deltacot1 mutant.	Zinc	49-51	plant EC metallothionein family protein	Arabidopsis thaliana	16-20
18287486-5	2008	The type-4 MTs (MT4a and MT4b) conferred greater Zn tolerance and higher accumulation of Zn than other MTs to the Deltazrc1 Deltacot1 mutant.	Zinc	89-91	plant EC metallothionein family protein	Arabidopsis thaliana	16-20
18368618-4	2008	Both TP types contained a variety of transition metals, including zinc (Zn), copper (Cu), aluminum, and iron.	Zinc	72-74	transition protein 2	Rattus norvegicus	5-7
18368618-5	2008	Zn and Cu were detected at high levels in water-soluble fractions (TP2 &gt; TP1).	Zinc	0-2	transition protein 2	Rattus norvegicus	67-70
18074158-4	2008	Protein tyrosine phosphatase 1B (PTP 1B), on the other hand, is not classified as a zinc enzyme but is strongly inhibited by Zn(II), with log K = 7.8 +/- 0.1.	Zinc	125-127	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-31
18074158-4	2008	Protein tyrosine phosphatase 1B (PTP 1B), on the other hand, is not classified as a zinc enzyme but is strongly inhibited by Zn(II), with log K = 7.8 +/- 0.1.	Zinc	125-127	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	33-39
18074158-6	2008	MT makes Zn(II) available for both PTP 1B and the apoform of SDH.	Zinc	9-15	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	35-41
18088336-6	2008	The Arabidopsis myb72 knockout mutant was more sensitive to excess Zn or iron (Fe) deficiency than wild type, while Arabidopsis transformants overexpressing bHLH100 showed increased tolerance to high Zn and nickel (Ni) compared to wild-type plants, confirming their role in metal homeostasis in Arabidopsis.	Zinc	200-202	basic helix-loop-helix protein 100	Arabidopsis thaliana	157-164
17604908-2	2008	Batch experiments were conducted to evaluate the interaction between Zn and glyphosate [N-(phosphonomethyl)glycine (GPS; H3L)] with regard to the effect of GPS on Zn adsorption on goethite.	Zinc	163-165	neurobeachin like 2	Homo sapiens	156-159
17604908-3	2008	The herbicide GPS markedly affected Zn adsorption on goethite when they coexisted in a goethite suspension.	Zinc	36-38	neurobeachin like 2	Homo sapiens	14-17
17604908-4	2008	When solution pH was not intentionally adjusted, addition of GPS decreased Zn adsorption on goethite, since the equilibrium solution pH was significantly decreased in the presence of GPS and correspondingly the negative surface charges of goethite decreased.	Zinc	75-77	neurobeachin like 2	Homo sapiens	61-64
17604908-4	2008	When solution pH was not intentionally adjusted, addition of GPS decreased Zn adsorption on goethite, since the equilibrium solution pH was significantly decreased in the presence of GPS and correspondingly the negative surface charges of goethite decreased.	Zinc	75-77	neurobeachin like 2	Homo sapiens	183-186
17604908-6	2008	At lower pH (pH&lt;5), the presence of GPS increased the adsorption of Zn, because Zn adsorbed on the sites of goethite via GPS bridge.	Zinc	71-73	neurobeachin like 2	Homo sapiens	39-42
17604908-6	2008	At lower pH (pH&lt;5), the presence of GPS increased the adsorption of Zn, because Zn adsorbed on the sites of goethite via GPS bridge.	Zinc	71-73	neurobeachin like 2	Homo sapiens	124-127
17604908-6	2008	At lower pH (pH&lt;5), the presence of GPS increased the adsorption of Zn, because Zn adsorbed on the sites of goethite via GPS bridge.	Zinc	83-85	neurobeachin like 2	Homo sapiens	39-42
17604908-6	2008	At lower pH (pH&lt;5), the presence of GPS increased the adsorption of Zn, because Zn adsorbed on the sites of goethite via GPS bridge.	Zinc	83-85	neurobeachin like 2	Homo sapiens	124-127
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	81-83	neurobeachin like 2	Homo sapiens	49-52
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	81-83	neurobeachin like 2	Homo sapiens	105-108
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	131-133	neurobeachin like 2	Homo sapiens	49-52
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	131-133	neurobeachin like 2	Homo sapiens	105-108
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	131-133	neurobeachin like 2	Homo sapiens	49-52
17604908-7	2008	However, at higher pH (pH&gt;5), the presence of GPS decreased the adsorption of Zn on goethite, because GPS reacted with solution Zn to form water-soluble complexes that had lower affinity to the goethite surface in comparison with Zn itself.	Zinc	131-133	neurobeachin like 2	Homo sapiens	105-108
32688753-1	2008	AtMHX is an Arabidopsis vacuolar transporter that exchanges protons with Mg2+, Zn2+ and Fe2+ ions.	Zinc	79-83	magnesium/proton exchanger	Arabidopsis thaliana	0-5
17847078-5	2008	We determined endogenous Zn(2+) exocytosis by direct observation of vesicular Zn(2+) as decreasing fluorescence intensity from presynaptic axonal boutons in the stratum lucidum of CA3 during neural activities induced by the stimulation of membrane depolarization.	Zinc	25-27	carbonic anhydrase 3	Rattus norvegicus	180-183
18061205-5	2008	This oxidation might be a consequence of a lower affinity for the second Zn located in the Cys site that would also explain the observed susceptibility of VIM-2 to chelating agents.	Zinc	73-75	VIM-2	Pseudomonas aeruginosa	155-160
17961647-5	2008	The hydration process does not cause the decomposition of surface phosphate groups and hydroxyl channel, but does affect the energetics of subsequent Zn substitution and occupation on Ca(I) and Ca(II) sites.	Zinc	150-152	carbonic anhydrase 1	Homo sapiens	184-189
19096101-4	2008	Furthermore, the reduction of the CoQ9 incorporated into HeLa cells was also inhibited by Zn2+ in the presence of pyrithione, a zinc ionophore.	Zinc	90-94	coenzyme Q9	Homo sapiens	34-38
18311544-0	2008	High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.	Zinc	19-23	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	47-53
18803194-3	2008	Among the nucleotides, the selective recognition and luminescence enhancement for TTP was achieved by the strong binding of the thymine unit to Zn2+-cyclen (cyclen=1,4,7,10-tetraazacyclododecane) and intermolecular energy transfer between the mCP and FIrpic moieties.	Zinc	144-148	CD46 antigen, complement regulatory protein	Mus musculus	243-246
18042200-7	2008	When YSL1 and YSL3 are nonfunctional, Cu, Fe, and Zn are not effectively remobilized from, or do not effectively pass through, leaf and maternal fruit tissues.	Zinc	50-52	YELLOW STRIPE like 3	Arabidopsis thaliana	14-18
17933919-3	2007	A robust set of genes that responded consistently to Zn limitation was identified, and the set enabled the definition of the Zn-specific Zap1p regulon, comprised of 26 genes and characterized by a broader zinc-responsive element consensus (MHHAACCBYNMRGGT) than so far described.	Zinc	125-127	Zap1p	Saccharomyces cerevisiae S288C	137-142
17699699-0	2007	Zn(2+) slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity.	Zinc	0-6	immunoglobulin lambda variable 7-46	Homo sapiens	18-26
17699699-1	2007	We employed whole cell patch-clamp recordings to establish the effect of Zn(2+) on the gating the brain specific, T-type channel isoform Ca(V)3.3 expressed in HEK-293 cells.	Zinc	73-75	immunoglobulin lambda variable 7-46	Homo sapiens	137-145
17699699-9	2007	These data demonstrate that Zn(2+) modulates Ca(V)3.3 channel gating thus leading to increased neuronal excitability.	Zinc	28-34	immunoglobulin lambda variable 7-46	Homo sapiens	45-53
17990563-8	2007	Rhizosphere and bulk soil Zn fractions were in the order of FeMn &gt; CAB &gt; RES &gt; OM &gt; EXC in Zn alone and Cd and Zn combined treatments, while the order was RES &gt; FeMn &gt; OM &gt; CAB &gt; EXC in Cd only treatment.	Zinc	26-28	neural proliferation, differentiation and control 1	Homo sapiens	70-73
17990563-8	2007	Rhizosphere and bulk soil Zn fractions were in the order of FeMn &gt; CAB &gt; RES &gt; OM &gt; EXC in Zn alone and Cd and Zn combined treatments, while the order was RES &gt; FeMn &gt; OM &gt; CAB &gt; EXC in Cd only treatment.	Zinc	103-105	neural proliferation, differentiation and control 1	Homo sapiens	70-73
17990563-8	2007	Rhizosphere and bulk soil Zn fractions were in the order of FeMn &gt; CAB &gt; RES &gt; OM &gt; EXC in Zn alone and Cd and Zn combined treatments, while the order was RES &gt; FeMn &gt; OM &gt; CAB &gt; EXC in Cd only treatment.	Zinc	103-105	neural proliferation, differentiation and control 1	Homo sapiens	70-73
17584508-0	2007	Spin-glass-like magnetic ordering in Zn substituted magnetite magnetic fluids.	Zinc	37-39	spindlin 1	Homo sapiens	0-4
17584508-1	2007	Electron spin resonance (ESR) spectra of magnetic fluids involving polydispersed Zn(0.5)Fe(0.	Zinc	81-83	spindlin 1	Homo sapiens	9-13
17544347-1	2007	We found that Zn(2+) conspicuously inactivated tyrosinase in a mixed-type inhibition manner: the final level of residual activity was abolished at the equilibrium state with concentration of 0.25 mM Zn(2+).	Zinc	14-16	tyrosinase	Homo sapiens	47-57
17544347-1	2007	We found that Zn(2+) conspicuously inactivated tyrosinase in a mixed-type inhibition manner: the final level of residual activity was abolished at the equilibrium state with concentration of 0.25 mM Zn(2+).	Zinc	199-201	tyrosinase	Homo sapiens	47-57
17544347-3	2007	To see whether Zn(2+) also induced conformational change of tyrosinase and how thermodynamical changes by ligand binding were occurred, the intrinsic fluorescence studies as well as calorimetric measurements were conducted.	Zinc	15-17	tyrosinase	Homo sapiens	60-70
17544347-4	2007	The results showed that the Zn(2+) binding to tyrosinase directly induced conformational change of tyrosinase, and the changes of thermodynamic parameters such as enthalpy (DeltaH), Gibbs free-energy (DeltaG), and entropy (DeltaS) were obtained as 60+/-7.0 kJ/mol, -14.54 kJ/mol and 248.53 J/(K mol), respectively.	Zinc	28-34	tyrosinase	Homo sapiens	46-56
17544347-4	2007	The results showed that the Zn(2+) binding to tyrosinase directly induced conformational change of tyrosinase, and the changes of thermodynamic parameters such as enthalpy (DeltaH), Gibbs free-energy (DeltaG), and entropy (DeltaS) were obtained as 60+/-7.0 kJ/mol, -14.54 kJ/mol and 248.53 J/(K mol), respectively.	Zinc	28-34	tyrosinase	Homo sapiens	99-109
17544347-5	2007	The inactivating effect of Zn(2+) on tyrosinase was completely prevented by incubation with bovine serum albumin, which has a Zn(2+) binding motif in its structure.	Zinc	27-33	tyrosinase	Homo sapiens	37-47
17544347-5	2007	The inactivating effect of Zn(2+) on tyrosinase was completely prevented by incubation with bovine serum albumin, which has a Zn(2+) binding motif in its structure.	Zinc	126-132	tyrosinase	Homo sapiens	37-47
20535396-2	2007	The present study evaluated whether Zn deficiency would negatively affect bone-related enzyme, ALP, and other bone-related minerals (Ca, P and Mg) in rats.	Zinc	36-38	PDZ and LIM domain 3	Rattus norvegicus	95-98
17408612-7	2007	Zn2+ allosterically inhibited transport in the human DAT (hDAT) with a KI=7.9+/-0.42 microM.	Zinc	0-4	solute carrier family 6 member 3	Homo sapiens	53-56
17408612-7	2007	Zn2+ allosterically inhibited transport in the human DAT (hDAT) with a KI=7.9+/-0.42 microM.	Zinc	0-4	solute carrier family 6 member 3	Homo sapiens	58-62
17408612-8	2007	Removal of endogenous Zn2+ with penicillamine in hDAT increased transport values.	Zinc	22-26	solute carrier family 6 member 3	Homo sapiens	49-53
17408612-10	2007	Zn2+ allosterically reduced the inhibition by cocaine in hDAT.	Zinc	0-4	solute carrier family 6 member 3	Homo sapiens	57-61
17408612-11	2007	Results of pre-steady-state studies demonstrated that Zn2+ increases the second order binding rate constant for dopamine to hDAT (3.5 fold to 19.2x10(6) M-1 s-1 for hDAT).	Zinc	54-58	solute carrier family 6 member 3	Homo sapiens	124-128
17408612-11	2007	Results of pre-steady-state studies demonstrated that Zn2+ increases the second order binding rate constant for dopamine to hDAT (3.5 fold to 19.2x10(6) M-1 s-1 for hDAT).	Zinc	54-58	solute carrier family 6 member 3	Homo sapiens	165-169
17657991-4	2007	Furthermore, the highest correlation coefficients were observed between RBC CA1 and Zn levels, and plasma thyroid hormone levels measured eight weeks earlier.	Zinc	84-86	carbonic anhydrase 1	Homo sapiens	76-79
17452788-3	2007	These trigonal crystals reveal the unexpected ability of Rac1 to coordinate Zn atoms in a tetrahedral fashion by use of its biologically relevant switch I and switch II regions.	Zinc	76-78	Rac family small GTPase 1	Homo sapiens	57-61
17188861-6	2007	Using this TACE-selective P1" group as an anchor, stereochemical and conformational constraints in the inhibitors, and restrictions to the active site Zn coordination geometry, we developed a highly plausible and predictive pharmacophore model that rationalizes the observed TACE activity of all three inhibitors.	Zinc	151-153	ADAM metallopeptidase domain 17	Homo sapiens	11-15
17188861-6	2007	Using this TACE-selective P1" group as an anchor, stereochemical and conformational constraints in the inhibitors, and restrictions to the active site Zn coordination geometry, we developed a highly plausible and predictive pharmacophore model that rationalizes the observed TACE activity of all three inhibitors.	Zinc	151-153	ADAM metallopeptidase domain 17	Homo sapiens	275-279
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	91-93	peptidoglycan recognition protein 4	Homo sapiens	61-69
17312159-2	2007	In this study, we demonstrate that human PGLYRP-1, PGLYRP-3, PGLYRP-4, and PGLYRP-3:4 have Zn(2+)-dependent bactericidal activity against both Gram-positive and Gram-negative bacteria at physiologic Zn(2+) concentrations found in serum, sweat, saliva, and other body fluids.	Zinc	199-201	peptidoglycan recognition protein 4	Homo sapiens	61-69
17157873-12	2007	Previously, we have discovered that mutations G262S (yielding IMP-1) and G262A in IMP-6 stabilize the Zn(II) ligand His263 and thus the enzyme-substrate intermediate complex through a domino effect, which enhances conversion of drugs like ceftazidime, penicillins, and imipenem.	Zinc	102-108	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	62-67
17269467-1	2007	Metallothionein is a small (6-kDa), cysteine-rich protein expressed by a six-zinc finger protein called metal-responsive element-binding transcription factor-1 (MTF-1) in response to Zn and Cd.	Zinc	183-185	metal-regulatory transcription factor 1	Danio rerio	104-159
17269467-1	2007	Metallothionein is a small (6-kDa), cysteine-rich protein expressed by a six-zinc finger protein called metal-responsive element-binding transcription factor-1 (MTF-1) in response to Zn and Cd.	Zinc	183-185	metal-regulatory transcription factor 1	Danio rerio	161-166
17269467-6	2007	Using fluorescence techniques, we have shown that Zn and Cd mediate cytoplasmic and nuclear translocation of MTF- 1-enhanced green fluorescent protein fusion protein in zebrafish liver cell line.	Zinc	50-52	metal-regulatory transcription factor 1	Danio rerio	109-115
17269467-9	2007	Electrophoretic mobility shift assay revealed binding of the recombinant MTF-1 in response to Zn and Cd at the putative metal-responsive elements (MREs) in the promoter region of the mt gene.	Zinc	94-96	metal-regulatory transcription factor 1	Danio rerio	73-78
17269467-10	2007	Taken together, these results suggest that Zn and Cd are efficiently involved with mt expression induced in zebrafish embryos and with MTF-1 nuclear translocation and that this induction is achieved through the activation of MTF-1 binding at the MREs.	Zinc	43-45	metal-regulatory transcription factor 1	Danio rerio	135-140
17269467-10	2007	Taken together, these results suggest that Zn and Cd are efficiently involved with mt expression induced in zebrafish embryos and with MTF-1 nuclear translocation and that this induction is achieved through the activation of MTF-1 binding at the MREs.	Zinc	43-45	metal-regulatory transcription factor 1	Danio rerio	225-230
17365795-4	2007	The [15N4]-HDPR model was used to simulate H-bonding and possible Zn2+-coordination of HDPR with ADA.	Zinc	66-70	adenosine deaminase	Homo sapiens	97-100
17158957-6	2006	Previously, we showed that UNC-97 interacts with UNC-98, a 37-kD protein, containing four C2H2 Zn fingers, that localizes to M-lines.	Zinc	95-97	LIM domain-containing protein unc-97	Caenorhabditis elegans	27-33
16377202-0	2006	An overview of copper radionuclides and production of 61Cu by proton irradiation of (nat)Zn at a medical cyclotron.	Zinc	89-91	bromodomain containing 2	Homo sapiens	85-88
17176903-6	2006	In relation with the daily ingestion of Zn, a statistically significant difference was observed only (p &lt; 0.001) in the severe undernourished, 1.87 +/- 0.54 mg/dia (1.20 mg/dia-2.87 mg/dia) when comparing them with the light undernourished, 5.48 +/- 0.98 mg/dia (3.50 mg/dia-7.87 mg/dia), the mild undernourished, 4.99 +/- 1.24 mg/dia (4.10 mg/dia-11.42 mg/dia) ) and the normal subjects, 6.22 +/- 0.98 mg/dia (4.8 mg/dia-8.02 mg/dia).	Zinc	40-42	diaphanous related formin 2	Homo sapiens	176-181
16971553-4	2006	Zn(II) in activating concentrations (100 microM) acted as an allosteric enhancer as it increased the B(max) (7.1-fold), the potency (9.9-fold), the affinity (1.7- and 6.1-fold in competition against agonist and inverse agonist, respectively), and the efficacy (2.5-fold) of CXCL1/GROalpha.	Zinc	0-6	C-X-C motif chemokine ligand 1	Homo sapiens	274-279
16971553-4	2006	Zn(II) in activating concentrations (100 microM) acted as an allosteric enhancer as it increased the B(max) (7.1-fold), the potency (9.9-fold), the affinity (1.7- and 6.1-fold in competition against agonist and inverse agonist, respectively), and the efficacy (2.5-fold) of CXCL1/GROalpha.	Zinc	0-6	C-X-C motif chemokine ligand 1	Homo sapiens	280-288
16971553-5	2006	The activating properties of Zn(II) were not due to a metal ion site between the ligand and the receptor because CXCL1/GROalpha analogs in which the putative metal-ion binding residues had been substituted-[H19A] and [H34A]-acted like wild-type CXCL1/GROalpha.	Zinc	29-31	C-X-C motif chemokine ligand 1	Homo sapiens	119-127
16971553-5	2006	The activating properties of Zn(II) were not due to a metal ion site between the ligand and the receptor because CXCL1/GROalpha analogs in which the putative metal-ion binding residues had been substituted-[H19A] and [H34A]-acted like wild-type CXCL1/GROalpha.	Zinc	29-31	C-X-C motif chemokine ligand 1	Homo sapiens	245-250
16971553-5	2006	The activating properties of Zn(II) were not due to a metal ion site between the ligand and the receptor because CXCL1/GROalpha analogs in which the putative metal-ion binding residues had been substituted-[H19A] and [H34A]-acted like wild-type CXCL1/GROalpha.	Zinc	29-31	C-X-C motif chemokine ligand 1	Homo sapiens	251-259
17125255-3	2006	As shown by X-ray crystallography, the sulfamide analogue binds to CA II with the deprotonated sulfamide moiety coordinated to Zn(II) and with the organic scaffold making an extended network of hydrogen bonds with Thr199, Gln92, His94, Asn62, and Thr200.	Zinc	127-129	carbonic anhydrase 2	Homo sapiens	67-72
17112287-3	2006	The interaction of 2 equiv of MX2 with L1 in n-BuOH at 110 degrees C gives the binuclear complexes, [(L1)M2X4] (M = Fe, X = Cl (1a); M = Co, X = Cl (1b); M = Ni, X = Br (1c); M = Zn, X = Cl (1d)), in which the metal centers adopt distorted tetrahedral geometries and occupy the two pyridyl-imine cavities in L1.	Zinc	179-181	MX dynamin like GTPase 2	Homo sapiens	30-33
17112287-4	2006	In contrast, deprotonation of L2-H occurs upon reaction with 2 equiv of MX2 to afford the phenolate-bridged species [(L2)M2(mu-X)X2] (M = Fe, X = Cl (2a); M = Co, X = Cl (2b); M = Ni, X = Br (2c); M = Zn, X = Cl (2d)).	Zinc	201-203	MX dynamin like GTPase 2	Homo sapiens	72-75
16973622-3	2006	It prevents FIH-1 from hydroxylating the asparagine residue (803) of HIF-1alpha in a Cu(II)- and Zn(II)-independent fashion.	Zinc	97-103	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	12-17
17261792-8	2006	MMPs are a family of Zn(2+)-dependent enzymes with proteolytic activity against connective tissue proteins such as collagens, proteoglycans, and elastin, which appear to play important roles in the development and progression of the atherosclerotic lesion.	Zinc	21-23	matrix metallopeptidase 9	Homo sapiens	0-4
17261792-8	2006	MMPs are a family of Zn(2+)-dependent enzymes with proteolytic activity against connective tissue proteins such as collagens, proteoglycans, and elastin, which appear to play important roles in the development and progression of the atherosclerotic lesion.	Zinc	21-23	elastin	Homo sapiens	145-152
17013754-6	2006	Raf-RBD pull-down experiments confirm that Zn treatment activates Ras and identified H-Ras as the specific isoform activated.	Zinc	43-45	GTPase HRas	Cricetulus griseus	85-90
16938414-4	2006	Here we report that the divalent ions Cd2+, Ni2+, and Zn2+ can inhibit the activity of a recombinant human N-methylpurine-DNA glycosylase (MPG) toward a deoxyoligonucleotide with ethenoadenine (varepsilonA).	Zinc	54-58	N-methylpurine DNA glycosylase	Homo sapiens	107-137
16938414-4	2006	Here we report that the divalent ions Cd2+, Ni2+, and Zn2+ can inhibit the activity of a recombinant human N-methylpurine-DNA glycosylase (MPG) toward a deoxyoligonucleotide with ethenoadenine (varepsilonA).	Zinc	54-58	N-methylpurine DNA glycosylase	Homo sapiens	139-142
16938414-6	2006	At concentrations starting from 50 to 1,000 microM, both Cd2+ and Zn2+ showed metal-dependent inhibition of the MPG catalytic activity.	Zinc	66-70	N-methylpurine DNA glycosylase	Homo sapiens	112-115
16938414-12	2006	Molecular dynamics (MD) simulations with Zn2+ showed that the MPG active site has a potential binding site for Zn2+, formed by several catalytically important and conserved residues.	Zinc	41-45	N-methylpurine DNA glycosylase	Homo sapiens	62-65
16938414-12	2006	Molecular dynamics (MD) simulations with Zn2+ showed that the MPG active site has a potential binding site for Zn2+, formed by several catalytically important and conserved residues.	Zinc	111-115	N-methylpurine DNA glycosylase	Homo sapiens	62-65
17029360-2	2006	To provide a chemical basis for this role, we prepared and studied a peptide corresponding to this sequence from the first iron-regulated transporter (IRT1) of Arabidopsis thaliana, which transports Fe2+ as well as Mn2+, Co2+, Zn2+, and Cd2+.	Zinc	227-231	iron-regulated transporter 1	Arabidopsis thaliana	151-155
17018876-3	2006	Finally, comparative in vitro and cellular experiments examined the relative reactivity of Zn- and apo-MT with nitric oxide species, showing that apo-MT is much more reactive chemically and that in cells it may be a principal reactive species within the MT pool.	Zinc	91-93	anterior polar opacity	Mus musculus	146-149
17042794-7	2006	Furthermore, neuronal cultures derived from the Wld(s) mouse, which overexpress the NAD(+) synthetic enzyme nicotinamide mononucleotide adenyl transferase (NMNAT-1), had reduced sensitivity to Zn(2+) neurotoxicity.	Zinc	193-195	nicotinamide nucleotide adenylyltransferase 1	Rattus norvegicus	156-163
16878961-3	2006	The methyl-for-picolyl substitutions in ZAP1 and ZAP2 have a negligible effect on the optical spectrum of the fluorophore but elevate the quantum yields (Phi = 0.82 (ZAP1), 0.74 (ZAP2)) to values near that of Zn2+-saturated ZP1 (Phi = 0.92).	Zinc	209-213	zinc finger protein 569	Homo sapiens	40-44
16545571-0	2006	Comments on the feasibility of 61Cu production by proton irradiation of (nat)Zn on a medical cyclotron.	Zinc	77-79	bromodomain containing 2	Homo sapiens	73-76
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	65-67	bromodomain containing 2	Homo sapiens	61-64
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16545571-2	2006	Based on the experimentally available cross-sections of the (nat)Zn(p,x) 61Cu, (nat)Zn(p,x) 60Cu and (nat)Zn(p,x) 64Cu nuclear processes the usefulness of the (nat)Zn(p,x) 61Cu process for high-scale production is questionable in the 22 --&gt; 12 MeV energy range.	Zinc	84-86	bromodomain containing 2	Homo sapiens	80-83
16410015-0	2006	Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+.	Zinc	148-152	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	14-42
16787097-2	2006	Its binding to hCA II is similar to that of other benzesulfonamides, with the ionized sulfonamide coordinated to the Zn2+ ion within the enzyme active site, and also participating in a network of hydrogen bonds with residues Thr199 and Glu106.	Zinc	117-121	carbonic anhydrase 2	Homo sapiens	15-21
16674922-3	2006	Here we show for the first time that Zn(2+)-induced aggregation of Abeta (10-21) potentiates its action on outward potassium currents in hippocampal CA1 pyramidal neurons.	Zinc	37-43	carbonic anhydrase 1	Homo sapiens	149-152
16581305-7	2006	In brain, 1.0 mg Zn(2+)/L resulted in an increase in CAT activity (126%), while 1.5 mg Ag(+)/L exposure caused a 54% decrease.	Zinc	17-19	catalase	Oreochromis niloticus	53-56
17080942-3	2006	We investigated the expression in Arabidopsis halleri of a homolog of AtMHX, an A. thaliana tonoplast transporter that exchanges protons with Mg, Zn and Fe ions.	Zinc	146-148	magnesium/proton exchanger	Arabidopsis thaliana	70-75
16484283-8	2006	Results show that Zn deficiency can increase the cytotoxicity of Pb2+ and the susceptibility of neurons to Pb2+-induced oxidative stress, leading to JNK and p38 phosphorylation and, subsequently, AP-1 activation.	Zinc	18-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-200
16626156-1	2006	Intramolecular reductive coupling of diimines in the presence of Zn/Ti(O(i)Pr)2Cl2 gives the corresponding (+/-)-2,3-diarylpiperazines in 73-83% yields with dl/meso ratio &gt;99%:&lt;1%.	Zinc	65-67	endogenous retrovirus group W member 5	Homo sapiens	79-82
16436387-0	2006	The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner.	Zinc	120-124	histidine rich glycoprotein	Homo sapiens	45-72
16489135-9	2006	Purified AtPCS1 and LjPCS1 were activated (in decreasing order) by Cd2+, Zn2+, Cu2+, and Fe3+, but not by Co2+ or Ni2+, in the presence of 5 mm GSH and 50 microm metal ions.	Zinc	73-77	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	9-15
16522806-6	2006	X-ray absorption near-edge structure (XANES) analysis identifies the PTD012-bound ion as Zn(2+).	Zinc	89-91	chromosome 11 open reading frame 54	Homo sapiens	69-75
16522806-8	2006	The binding of Zn(2+) to PTD012 is reminiscent of zinc-containing enzymes such as carboxypeptidase, carbonic anhydrase, and beta-lactamase.	Zinc	15-21	chromosome 11 open reading frame 54	Homo sapiens	25-31
16411690-2	2006	Like the parent ZP1, both Me(2)ZP1 and Me(4)ZP1 exhibit increased fluorescence in the presence of Zn(2+).	Zinc	98-100	zona pellucida glycoprotein 1	Homo sapiens	16-19
16411690-2	2006	Like the parent ZP1, both Me(2)ZP1 and Me(4)ZP1 exhibit increased fluorescence in the presence of Zn(2+).	Zinc	98-100	zona pellucida glycoprotein 1	Homo sapiens	31-34
16411690-2	2006	Like the parent ZP1, both Me(2)ZP1 and Me(4)ZP1 exhibit increased fluorescence in the presence of Zn(2+).	Zinc	98-100	zona pellucida glycoprotein 1	Homo sapiens	31-34
16411690-3	2006	The integrated emission of Me(2)ZP1 increases 4-fold in the presence of excess zinc, whereas Me(4)ZP1 displays 2.5-fold enhanced fluorescence for Zn(2+).	Zinc	146-148	zona pellucida glycoprotein 1	Homo sapiens	98-101
16239244-7	2005	Fe-chelatase activities were similar in mutants and controls, whereas Zn-chelatase activities were slightly elevated in mutants, supporting the idea of an altered metal-specificity of ferrochelatase.	Zinc	70-72	ferrochelatase	Homo sapiens	184-198
16023236-4	2005	The distribution of parvalbumin, a calcium binding protein, showed a reverse gradient to that of Zn.	Zinc	97-99	parvalbumin	Homo sapiens	20-31
16023236-7	2005	A mixed population of labeled neurons was visualized, which included Zn+ neurons in CA1 of the hippocampus and in several amygdala subnuclei.	Zinc	69-72	carbonic anhydrase 1	Homo sapiens	84-87
16023236-8	2005	In CA1, Zn+ neurons were restricted to the upper part of stratum pyramidale.	Zinc	8-11	carbonic anhydrase 1	Homo sapiens	3-6
16093311-2	2005	A striking feature is a delayed rise in intracellular free Zn(2+) in CA1 neurons just before the onset of histologically detectable cell death.	Zinc	59-61	carbonic anhydrase 1	Homo sapiens	69-72
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	212-214	carbonic anhydrase 1	Homo sapiens	142-145
16093311-3	2005	Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death.	Zinc	287-289	carbonic anhydrase 1	Homo sapiens	142-145
16093311-6	2005	Naspm injected intrahippocampally at 9-40 h after insult greatly reduced the late rise in intracellular free Zn(2+) in postischemic CA1 neurons and afforded partial protection against ischemia-induced cell death.	Zinc	109-111	carbonic anhydrase 1	Homo sapiens	132-135
16005709-2	2005	In addition, IFN-alpha promotes redistribution of zinc (Zn) from the plasma to the liver in mice.	Zinc	56-58	interferon alpha	Mus musculus	13-22
16028930-8	2005	Thus, by using a combination of sensor molecules, it was demonstrated for the first time that a higher Zn(2+) concentration is released in DG than in CA3 or CA1 and that we can easily visualize Zn(2+) concentration over a wide range.	Zinc	103-109	carbonic anhydrase 1	Homo sapiens	157-160
15955876-7	2005	This result is surprising because structural studies of Kv4-T1 crystals predicted protection of the targeted thiolate groups by constitutive high-affinity Zn(2+) coordination.	Zinc	155-157	potassium voltage-gated channel subfamily C member 1	Homo sapiens	56-59
15955876-10	2005	These results conclusively demonstrate that the T1--T1 interface of Kv4 channels is functionally active and dynamic, and that critical reactive thiolate groups in this interface may not be protected by Zn(2+) binding.	Zinc	202-208	potassium voltage-gated channel subfamily C member 1	Homo sapiens	68-71
15897968-7	2005	The deduced protein structure of NYD-SP5 was found to contain an IQ motif (a short calmodulin-binding motif containing conserved Ile and Gln residues), a Carbamate kinase-like domain, a Zn-dependent exopeptidase domain and a lactate dehydrogenase (LDH) C-terminal-like domain.	Zinc	186-188	IQ motif containing H	Homo sapiens	33-40
15887030-2	2005	However, we have found that Rck2 is subject to intracellular degradation after exposure of cells to Zn2+ concentrations of 5 mM or more.	Zinc	100-104	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	28-32
15823027-3	2005	As with other S100 protein structures, the quaternary structure of Zn(2+)-Ca(2+)-bound S100B was found to be dimeric with helices H1, H1", H4, and H4" forming an X-type four-helix bundle at the dimer interface.	Zinc	67-73	S100 calcium binding protein B	Rattus norvegicus	87-92
15823027-4	2005	NMR data together with mutational analyses are consistent with Zn(2+) coordination arising from His-15 and His-25 of one S100B subunit and from His-85 and Glu-89 of the other subunit.	Zinc	63-65	S100 calcium binding protein B	Rattus norvegicus	121-126
15823027-6	2005	Furthermore, a kink in helix 4 was observed in Zn(2+)-Ca(2+)-bound S100B that is not in Ca(2+)-bound S100B.	Zinc	47-53	S100 calcium binding protein B	Rattus norvegicus	67-72
15943174-5	2005	Moreover, 10(-4) and 10(-5) M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release.	Zinc	30-32	negative elongation factor complex member C/D	Homo sapiens	83-86
15804357-14	2005	Large external concentrations of some cations inhibited Mg2+ transport (Ni2+, Zn2+, Mn2+) in MagT1-expressing oocytes.	Zinc	78-82	magnesium transporter 1	Homo sapiens	93-98
15665557-1	2005	BACKGROUND: The aim of this work was to characterize the relationship between zinc (Zn(2+)) and cadmium (Cd(2+)) and the toxic effects of Cd(2+) in immortalized renal proximal tubule cells RP1.	Zinc	84-90	uncharacterized protein LOC100355685	Oryctolagus cuniculus	189-192
15964699-10	2005	We therefore propose that release of Zn(2+)-mediated inhibition of NMDA receptors by HIV-1 Tat contributes to the neurotoxic effect of glutamate and may participate in the pathogenesis of AIDS-associated dementia.	Zinc	37-43	Tat	Human immunodeficiency virus 1	91-94
15360251-5	2004	The pentacoordinated Zn sites in the latter complexes have distorted TBP geometry (tau = 0.74), while the corresponding Cu site in 1 has a highly distorted square pyramidal structure (tau = 0.54).	Zinc	21-23	TATA-box binding protein	Homo sapiens	69-72
15360262-9	2004	It shows a distorted tetrahedral coordination geometry for the zinc(II) ions in an NS3 coordination sphere.	Zinc	63-71	KRAS proto-oncogene, GTPase	Homo sapiens	83-86
15220341-5	2004	HRG was also shown to tether plasminogen to cell surfaces, with this interaction being potentiated by elevated Zn(2+) levels and low pH, conditions that prevail at sites of tissue injury, tumor growth, and angiogenesis.	Zinc	111-117	histidine rich glycoprotein	Homo sapiens	0-3
15301552-6	2004	For ADA, an inverse (18)k(nuc) of 0.986 +/- 0.001 is observed, reflecting coordination of the nucleophile by an active site Zn(2+) ion and a stepwise mechanism.	Zinc	124-130	adenosine deaminase	Homo sapiens	4-7
15219426-2	2004	The adsorption equilibrium and kinetics of O2/H2O on Zn have been measured at different temperatures and relative humidities using a Cahn 1000 vacuum recording electrobalance.	Zinc	53-55	immunoglobulin kappa variable 1D-39	Homo sapiens	43-49
15138272-0	2004	Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation.	Zinc	102-106	histidine rich glycoprotein	Homo sapiens	0-27
15138272-5	2004	In this study, HRG was shown to bind to most cell lines in a Zn(2+)-dependent manner, but failed to interact with the Chinese hamster ovary cell line pgsA-745, which lacks cell-surface glycosaminoglycans (GAGs).	Zinc	61-63	histidine-rich glycoprotein	Cricetulus griseus	15-18
15138272-10	2004	In contrast, synthetic peptides corresponding to the Zn(2+)-binding HRR of HRG did not interact with cells.	Zinc	53-59	histidine rich glycoprotein	Homo sapiens	75-78
15138272-11	2004	Furthermore, the binding of full-length HRG, but not the N1N2 domain, was greatly potentiated by physiological concentrations of Zn2+.	Zinc	129-133	histidine rich glycoprotein	Homo sapiens	40-43
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	50-54	solute carrier family 6 member 5 S homeolog	Xenopus laevis	95-100
15031290-4	2004	In this study we have investigated the actions of Zn2+ on the glycine transporters, GLYT1b and GLYT2a, expressed in Xenopus laevis oocytes and we demonstrate that Zn2+ is a noncompetitive inhibitor of GLYT1 but has no effect on GLYT2.	Zinc	163-167	solute carrier family 6 member 5 S homeolog	Xenopus laevis	95-100
14724195-3	2004	A slow gating process closes both protopores simultaneously, has a high Q(10), is facilitated by extracellular Zn(2+) and Cd(2+) and is abolished or markedly reduced by mutation of a cysteine conserved in ClC-0, -1 and -2.	Zinc	111-113	chloride voltage-gated channel 1	Homo sapiens	205-221
12639846-9	2004	LPS+thymulin+Zn(2+)-treated explants showed proliferation of CCAAT-enhancer binding protein-beta (C/EBPbeta) and fibroblast growth factor-9 immunoreactive mesenchyme, which was abolished by IL-6 antisense oligonucleotides.	Zinc	13-15	CCAAT/enhancer binding protein beta	Rattus norvegicus	61-96
12639846-9	2004	LPS+thymulin+Zn(2+)-treated explants showed proliferation of CCAAT-enhancer binding protein-beta (C/EBPbeta) and fibroblast growth factor-9 immunoreactive mesenchyme, which was abolished by IL-6 antisense oligonucleotides.	Zinc	13-15	CCAAT/enhancer binding protein beta	Rattus norvegicus	98-107
14612438-0	2004	Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.	Zinc	0-4	solute carrier family 39 (zinc transporter), member 4	Mus musculus	35-40
14680760-0	2004	Zn2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release.	Zinc	0-4	solute carrier family 6 member 3	Homo sapiens	41-61
15120848-3	2004	We report here the real time observation of increase of the concentration of extracellular Zn(2+) ([Zn(2+)](o)), accompanied by a rapid increase of intracellular free Zn(2+)concentration, in the areas of dentate gyrus (DG), CA1 and CA3 in acute rat hippocampus slices during ischemia simulated by deprivation of oxygen and glucose (OGD) followed by reperfusion with normal artificial cerebrospinal fluid.	Zinc	91-93	carbonic anhydrase 3	Rattus norvegicus	232-235
15120848-3	2004	We report here the real time observation of increase of the concentration of extracellular Zn(2+) ([Zn(2+)](o)), accompanied by a rapid increase of intracellular free Zn(2+)concentration, in the areas of dentate gyrus (DG), CA1 and CA3 in acute rat hippocampus slices during ischemia simulated by deprivation of oxygen and glucose (OGD) followed by reperfusion with normal artificial cerebrospinal fluid.	Zinc	100-102	carbonic anhydrase 3	Rattus norvegicus	232-235
14506276-9	2003	The Zn2+ binding amino acids (conserved in PGRP-L and T7 amidase) and Cys-419 (not conserved in T7 amidase) are required for the amidase activity of PGRP-L, whereas three other amino acids, needed for the activity of T7 amidase, are not required for the activity of PGRP-L.	Zinc	4-8	peptidoglycan recognition protein 2	Homo sapiens	43-49
14581177-0	2003	Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions.	Zinc	115-119	purinergic receptor P2Y2	Rattus norvegicus	41-45
32689086-10	2003	By contrast, Zn2+ and Cu2+ dramatically inactivated A6PR activity.	Zinc	13-17	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	52-56
32689086-11	2003	A6PR activity was decreased approximately 50 and 70%, respectively, when the enzyme was pre-incubated with 2 mM Zn2+ or Cu2+ for 60 min at room temperature.	Zinc	112-116	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	0-4
32689086-13	2003	NADPH and NADP+, which are substrates for A6PR in the oxidative and reductive directions, respectively, partially protected A6PR from inactivation by Zn2+.	Zinc	150-154	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	42-46
32689086-13	2003	NADPH and NADP+, which are substrates for A6PR in the oxidative and reductive directions, respectively, partially protected A6PR from inactivation by Zn2+.	Zinc	150-154	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	124-128
14612149-4	2003	In this review, it will be described how we have used Zn2+-binding sites as a tool to probe the structure and function of Na+/Cl--coupled biogenic amine transporters with specific focus on the human DAT (hDAT).	Zinc	54-58	solute carrier family 6 member 3	Homo sapiens	199-202
14612149-4	2003	In this review, it will be described how we have used Zn2+-binding sites as a tool to probe the structure and function of Na+/Cl--coupled biogenic amine transporters with specific focus on the human DAT (hDAT).	Zinc	54-58	solute carrier family 6 member 3	Homo sapiens	204-208
14612150-5	2003	Several metals impair binding to the DAT and/or the dopamine transport, but, under specific conditions, some of them, and chiefly Zn2+, stimulate binding.	Zinc	130-134	solute carrier family 6 member 3	Homo sapiens	37-40
14612150-6	2003	The complex relationships between cations, uptake blockers and the DAT suggest that cations recognise at least three different sites: the first one, site 1, is for cation-induced binding inhibition; the second one, site 2, is for Na+-induced binding stimulation; and the third one, site 3, is for Zn2+-induced binding stimulation.	Zinc	297-301	solute carrier family 6 member 3	Homo sapiens	67-70
14515014-2	2003	Herein, we describe the mechanism by which zinc (Zn2+) maintains IGF-II in an active form by directly regulating IGF-II binding to IGF-binding proteins (IGFBPs) and the type 1 IGF receptor (IGF-1R).	Zinc	49-53	insulin like growth factor 1 receptor	Homo sapiens	190-196
14515014-7	2003	In contrast, Zn2+ enhanced [125I]IGF-II binding to the IGF-1R by enhancing the rate of ligand association and decreasing the rate of dissociation.	Zinc	13-17	insulin like growth factor 1 receptor	Homo sapiens	55-61
14515014-9	2003	Together with the current work, these findings imply that Zn2+ acts in vivo to prevent secreted IGF-II from binding to IGFBP-3 and IGFBP- 5, thus maintaining IGF-II in an "active state," i.e., readily available for IGF-1R association.	Zinc	58-62	insulin like growth factor 1 receptor	Homo sapiens	215-221
12787249-9	2003	Upon Fe starvation, AtNRAMP3 disruption leads to increased accumulation of manganese (Mn) and zinc (Zn) in the roots, whereas AtNRAMP3 overexpression downregulates Mn accumulation.	Zinc	100-102	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	20-28
12619798-3	2003	In Experiment 1, an in vitro enzyme assay was used to evaluate the effects of Zn, Cu, Mg, and Mn on the activity of microbial uricase.	Zinc	78-80	urate oxidase (pseudogene)	Homo sapiens	126-133
12619798-6	2003	The results indicated that Zn and Cu greatly blocked the activity of microbial uricase (&gt;90% inhibition), whereas Mg and Mn were less inhibitory.	Zinc	27-29	urate oxidase (pseudogene)	Homo sapiens	79-86
12568924-5	2003	For Zn C3A/C26A azurin, the two techniques reveal the same transition temperature.	Zinc	4-6	complement C3	Homo sapiens	7-10
12568924-11	2003	as the reference state, for both Cu and Zn C3A/C26A azurin the unfolding free energy is decreased by about 28 kJ/mol, indicating that metal substitution is not able to compensate the destabilising effect induced by the disulfide bridge depletion.	Zinc	40-42	complement C3	Homo sapiens	43-46
12524046-4	2003	The hypothesis tested was that Ag activates the MT-A promoter indirectly by displacing Zn from pre-existing Zn-MT and that this liberated Zn subsequently induces MT synthesis.	Zinc	87-89	metallothionein A	Oncorhynchus mykiss	48-52
12524046-4	2003	The hypothesis tested was that Ag activates the MT-A promoter indirectly by displacing Zn from pre-existing Zn-MT and that this liberated Zn subsequently induces MT synthesis.	Zinc	108-110	metallothionein A	Oncorhynchus mykiss	48-52
12508053-3	2003	Here we report that heterologously overexpressed TRPM7 in HEK-293 cells conducts a range of essential and toxic divalent metal ions with strong preference for Zn(2+) and Ni(2+), which both permeate TRPM7 up to four times better than Ca(2+).	Zinc	159-161	transient receptor potential cation channel subfamily M member 7	Homo sapiens	49-54
12508053-3	2003	Here we report that heterologously overexpressed TRPM7 in HEK-293 cells conducts a range of essential and toxic divalent metal ions with strong preference for Zn(2+) and Ni(2+), which both permeate TRPM7 up to four times better than Ca(2+).	Zinc	159-161	transient receptor potential cation channel subfamily M member 7	Homo sapiens	198-203
12372517-1	2002	Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn(2+)-dependent inhibitor (1).	Zinc	157-163	KRAS proto-oncogene, GTPase	Homo sapiens	110-113
12372517-3	2002	This compound (46) binds also to NS3/NS4A in a Zn(2+) independent fashion (K(i)=1microM).	Zinc	47-49	KRAS proto-oncogene, GTPase	Homo sapiens	33-36
12372517-4	2002	The SAR of this class of compounds under Zn(2+) conditions is highly divergent compared to the SAR in the absence of Zn(2+), suggesting two distinct binding modes.	Zinc	41-43	sarcosine dehydrogenase	Homo sapiens	4-7
12372517-4	2002	The SAR of this class of compounds under Zn(2+) conditions is highly divergent compared to the SAR in the absence of Zn(2+), suggesting two distinct binding modes.	Zinc	117-119	sarcosine dehydrogenase	Homo sapiens	4-7
12421840-7	2002	Rats fed a low Zn or low vitamin A diet had lower ZnT-1 protein and higher ZnT-4 mRNA expression and protein levels compared with controls.	Zinc	15-17	solute carrier family 30 member 4	Rattus norvegicus	75-80
12224947-3	2002	TACE is a metalloprotease containing a catalytic glutamic acid, Glu-406, and a Zn(2+) ion ligated to three imidazoles.	Zinc	79-81	ADAM metallopeptidase domain 17	Homo sapiens	0-4
12220637-0	2002	Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3.	Zinc	46-48	metallothionein 3	Homo sapiens	102-119
12220637-3	2002	We have used electrospray ionization mass spectrometry to probe conformational states of cadmium- and zinc-substituted metalloforms of MT-3 and can demonstrate that the N-terminal beta-domain of MT-3 filled with Cd(2+) has a more open conformation than that filled with Zn(2+).	Zinc	270-272	metallothionein 3	Homo sapiens	135-139
12220637-3	2002	We have used electrospray ionization mass spectrometry to probe conformational states of cadmium- and zinc-substituted metalloforms of MT-3 and can demonstrate that the N-terminal beta-domain of MT-3 filled with Cd(2+) has a more open conformation than that filled with Zn(2+).	Zinc	270-272	metallothionein 3	Homo sapiens	195-199
12509288-6	2002	Cd(2+) and Zn(2+), but not other divalent cations tested, suppressed mOgg1-catalyzed reactions.	Zinc	11-13	8-oxoguanine DNA-glycosylase 1	Mus musculus	69-74
12107071-1	2002	Reactive changes in free intracellular zinc cation concentration ([Zn(2+)](i)) were monitored, using the fluorescent probe Zinquin, in human lymphoma cells exposed to the DNA-damaging agent VP-16.	Zinc	67-73	host cell factor C1	Homo sapiens	190-195
12107071-6	2002	Reducing [Zn(2+)](i), using N,N,N",N"-tetrakis(2-pyridylmethyl)ethylenediamine, caused rapid apoptosis in both p53(wt) and p53(mut) cells, although cotreatment with VP-16 exacerbated apoptosis only in p53(wt) cells.	Zinc	10-16	host cell factor C1	Homo sapiens	165-170
12119362-0	2002	Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits.	Zinc	12-16	carbonic anhydrase 3	Rattus norvegicus	106-109
12119362-5	2002	Electrophysiological analyses revealed that NMDA receptor-mediated synaptic responses in CA3 proximal stratum radiatum were inhibited in the immediate aftermath of MF activation and that this inhibition was no longer observed in the presence of a Zn2+-chelating agent.	Zinc	247-251	carbonic anhydrase 3	Rattus norvegicus	89-92
11895433-1	2002	The importance of two putative Zn2+-binding (Asp347, Glu429) and two catalytic (Arg431, Lys354) residues in the tomato leucine aminopeptidase (LAP-A) function was tested.	Zinc	31-35	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	143-148
11895433-9	2002	One catalytic (Arg431) and one Zn-binding (Asp347) residue were essential for His6-LAP-A activity, as most R431 and D347 mutant His6-LAP-As did not hydrolyze dipeptides.	Zinc	31-33	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	83-88
11752207-6	2002	These results provide evidence that Zn(2+) released at nerve terminals may modulate signals generated by the beta2AR in vivo.	Zinc	36-38	adrenoceptor beta 2	Homo sapiens	109-116
11551982-7	2001	Several intracellular signals are candidates for mediating changes in cyclic GMP sensitivity including transition metals, such as Ni(2+) and Zn(2+), and lipid metabolites, such as diacylglycerol.	Zinc	141-143	5'-nucleotidase, cytosolic II	Homo sapiens	77-80
11454945-5	2001	Murine IFN-beta could be coordinately conjugated with the DTPA-pullulan by simple mixing in an aqueous solution containing zinc ion (Zn2+).	Zinc	133-137	interferon beta 1, fibroblast	Mus musculus	7-15
11454945-6	2001	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn2+ coordination enhanced liver induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), to a greater extent than that by free IFN-beta, although the 2-5AS levels in the liver depended on the mixing ratio of the IFN-beta/DTPA residue of DTPA-pullulan/Zn2+.	Zinc	67-71	interferon beta 1, fibroblast	Mus musculus	29-37
11454945-6	2001	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn2+ coordination enhanced liver induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), to a greater extent than that by free IFN-beta, although the 2-5AS levels in the liver depended on the mixing ratio of the IFN-beta/DTPA residue of DTPA-pullulan/Zn2+.	Zinc	67-71	interferon beta 1, fibroblast	Mus musculus	213-221
11454945-6	2001	Intravenous injection of the IFN-beta-DTPA-pullulan conjugate with Zn2+ coordination enhanced liver induction of an antiviral enzyme, 2",5"-oligoadenylate synthetase (2-5AS), to a greater extent than that by free IFN-beta, although the 2-5AS levels in the liver depended on the mixing ratio of the IFN-beta/DTPA residue of DTPA-pullulan/Zn2+.	Zinc	67-71	interferon beta 1, fibroblast	Mus musculus	213-221
11404220-8	2001	Furthermore, the protein kinase activities of mTOR immunoprecipitated from rat brain lysates were stimulated two- to fivefold by 10-300 microM Zn2+ in the presence of an excess of either Mn2+ or Mg2+, whereas incubation with 1,10-phenanthroline had no effect.	Zinc	143-147	mechanistic target of rapamycin kinase	Rattus norvegicus	46-50
11312263-4	2001	AHNAK binds to S100B-Sepharose beads and is also recovered in anti-S100B immunoprecipitates in a strict Ca(2+)- and Zn(2+)-dependent manner.	Zinc	116-122	S100 calcium binding protein B	Rattus norvegicus	67-72
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-49	S100 calcium binding protein B	Rattus norvegicus	70-75
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-49	S100 calcium binding protein B	Rattus norvegicus	102-107
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-49	S100 calcium binding protein B	Rattus norvegicus	102-107
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-53	S100 calcium binding protein B	Rattus norvegicus	70-75
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-53	S100 calcium binding protein B	Rattus norvegicus	102-107
11312263-7	2001	We also provide evidence that the binding of 2 Zn(2+) equivalents/mol S100B enhances Ca(2+)-dependent S100B-AHNAK interaction and that the effect of Zn(2+) relies on Zn(2+)-dependent regulation of S100B affinity for Ca(2+).	Zinc	47-53	S100 calcium binding protein B	Rattus norvegicus	102-107
11240140-3	2001	In the present study, RBP expression was determined in HepG2 cells cultured in either Zn adequate media or chelated media containing varying concentrations of Zn.	Zinc	86-88	retinol binding protein 4	Homo sapiens	22-25
11240140-3	2001	In the present study, RBP expression was determined in HepG2 cells cultured in either Zn adequate media or chelated media containing varying concentrations of Zn.	Zinc	159-161	retinol binding protein 4	Homo sapiens	22-25
11240140-4	2001	Levels of RBP mRNA increased in a time- and Zn concentration-dependent manner such that 0.5 microM Zn-treated cells exhibited a &gt;7.5-fold increase while cells treated with 15 microM Zn were increased 2.9-fold at 72 h compared to controls.	Zinc	44-46	retinol binding protein 4	Homo sapiens	10-13
11240140-4	2001	Levels of RBP mRNA increased in a time- and Zn concentration-dependent manner such that 0.5 microM Zn-treated cells exhibited a &gt;7.5-fold increase while cells treated with 15 microM Zn were increased 2.9-fold at 72 h compared to controls.	Zinc	99-101	retinol binding protein 4	Homo sapiens	10-13
11240140-4	2001	Levels of RBP mRNA increased in a time- and Zn concentration-dependent manner such that 0.5 microM Zn-treated cells exhibited a &gt;7.5-fold increase while cells treated with 15 microM Zn were increased 2.9-fold at 72 h compared to controls.	Zinc	99-101	retinol binding protein 4	Homo sapiens	10-13
11240140-5	2001	RBP protein also progressively increased by 72 h to levels &gt;8-fold and 3-fold higher than controls, in 0.5 microM and 15 microM Zn-treated cells, respectively.	Zinc	131-133	retinol binding protein 4	Homo sapiens	0-3
11240140-6	2001	The increase in RBP occurred without any change in DNA concentration between groups through 72 h. The Zn deficiency-induced elevations in RBP transcript levels could be reversed within 24-48 h of repletion in Zn adequate media.	Zinc	102-104	retinol binding protein 4	Homo sapiens	16-19
11240140-6	2001	The increase in RBP occurred without any change in DNA concentration between groups through 72 h. The Zn deficiency-induced elevations in RBP transcript levels could be reversed within 24-48 h of repletion in Zn adequate media.	Zinc	102-104	retinol binding protein 4	Homo sapiens	138-141
11240140-6	2001	The increase in RBP occurred without any change in DNA concentration between groups through 72 h. The Zn deficiency-induced elevations in RBP transcript levels could be reversed within 24-48 h of repletion in Zn adequate media.	Zinc	209-211	retinol binding protein 4	Homo sapiens	16-19
11240140-6	2001	The increase in RBP occurred without any change in DNA concentration between groups through 72 h. The Zn deficiency-induced elevations in RBP transcript levels could be reversed within 24-48 h of repletion in Zn adequate media.	Zinc	209-211	retinol binding protein 4	Homo sapiens	138-141
11222124-7	2001	We observed that Zn(2+) is not transported through the membrane of Xenopus laevis oocytes by either transporter, even though it inhibits the transport of the other metal ions and enables protons to "slip" through the DCT1 transporter.	Zinc	17-19	solute carrier family 11 member 2 L homeolog	Xenopus laevis	217-221
11172754-8	2001	It is concluded that (1) Cd2+ can directly affect nerve cells, (2) toxicity of Cd2+ on Me5 neurons is mediated by continuous elevation in [Ca2+](i), (3) Cd2+ induces necrotic cell death, and (4) Cd2+ neurotoxicity can be antagonized by Zn2+.	Zinc	236-240	Cd2 molecule	Rattus norvegicus	25-28
11172754-8	2001	It is concluded that (1) Cd2+ can directly affect nerve cells, (2) toxicity of Cd2+ on Me5 neurons is mediated by continuous elevation in [Ca2+](i), (3) Cd2+ induces necrotic cell death, and (4) Cd2+ neurotoxicity can be antagonized by Zn2+.	Zinc	236-240	Cd2 molecule	Rattus norvegicus	79-82
11172754-8	2001	It is concluded that (1) Cd2+ can directly affect nerve cells, (2) toxicity of Cd2+ on Me5 neurons is mediated by continuous elevation in [Ca2+](i), (3) Cd2+ induces necrotic cell death, and (4) Cd2+ neurotoxicity can be antagonized by Zn2+.	Zinc	236-240	Cd2 molecule	Rattus norvegicus	79-82
11172754-8	2001	It is concluded that (1) Cd2+ can directly affect nerve cells, (2) toxicity of Cd2+ on Me5 neurons is mediated by continuous elevation in [Ca2+](i), (3) Cd2+ induces necrotic cell death, and (4) Cd2+ neurotoxicity can be antagonized by Zn2+.	Zinc	236-240	Cd2 molecule	Rattus norvegicus	79-82
11172020-4	2001	Zn(2+)-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the "natural killer (NK) cell immune synapse," observed at the site of contact between the NK cell and target cell.	Zinc	0-2	major histocompatibility complex, class I, C	Homo sapiens	97-102
11156944-10	2001	We presume that the mechanism of TACE activation by H2O2 is due to an oxidative attack of the pro-domain thiol group and disruption of its inhibitory coordination with the Zn++ in the catalytic domain of TACE.	Zinc	172-176	ADAM metallopeptidase domain 17	Homo sapiens	33-37
11032836-2	2001	Human PBGS purifies with eight Zn(II) per homo-octamer; four ZnA have predominantly nonsulfur ligands, and four ZnB have predominantly sulfur ligands.	Zinc	31-33	aminolevulinate dehydratase	Homo sapiens	6-10
24728862-1	2014	Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+ into cells.	Zinc	153-157	solute carrier family 39 member 8	Homo sapiens	6-13
24728862-1	2014	Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+ into cells.	Zinc	153-157	solute carrier family 39 member 14	Homo sapiens	18-26
24728862-1	2014	Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+ into cells.	Zinc	153-157	solute carrier family 39 member 8	Homo sapiens	40-44
24728862-1	2014	Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+ into cells.	Zinc	153-157	solute carrier family 39 member 14	Homo sapiens	49-54
24758941-7	2014	Toward MMP-2, Gd@C82(OH)22 could block either the Zn(2+)-catalylitic site directly or the S1" loop indirectly.	Zinc	50-56	matrix metallopeptidase 2	Homo sapiens	7-12
24632943-1	2014	With the help of density functional calculations using the HSE and PBE functionals, it is shown that incorporation of nitrogen into ZnO nanoparticles is energetically less costly compared to ZnO bulk, due to charge transfer between Zn dangling bonds and the NO impurity.	Zinc	132-134	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	67-70
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Zinc	161-163	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Zinc	270-272	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24719342-3	2014	Recently, it has been reported that metal ions such as copper(II) and zinc(II) are implicated in the aggregation of IAPP as well as able to modulate the proteolytic activity of IAPP degrading enzymes.	Zinc	70-78	islet amyloid polypeptide	Homo sapiens	116-120
24719342-3	2014	Recently, it has been reported that metal ions such as copper(II) and zinc(II) are implicated in the aggregation of IAPP as well as able to modulate the proteolytic activity of IAPP degrading enzymes.	Zinc	70-78	islet amyloid polypeptide	Homo sapiens	177-181
24514587-12	2014	In the Andean population, the genotypes of SLC39A14 rs4872479 and rs870215 associated with lower Ery-Cd showed positive correlations with plasma-Zn (P-Zn) and SLC39A14 expression.	Zinc	145-147	solute carrier family 39 member 14	Homo sapiens	43-51
24333596-6	2014	Herein we determined effects of PRL-R attenuation on cellular Zn metabolism and cell function in a model of ER-, PRL-R over-expressing breast cancer cells (MDA-MB-453).	Zinc	62-64	prolactin receptor	Homo sapiens	32-37
24333596-7	2014	PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria.	Zinc	51-53	prolactin receptor	Homo sapiens	0-5
24333596-8	2014	ZnT2-mediated lysosomal Zn sequestration was associated with reduced matrix metalloproteinase 2 (MMP-2) activity and decreased invasion.	Zinc	0-2	matrix metallopeptidase 2	Homo sapiens	69-95
24333596-8	2014	ZnT2-mediated lysosomal Zn sequestration was associated with reduced matrix metalloproteinase 2 (MMP-2) activity and decreased invasion.	Zinc	0-2	matrix metallopeptidase 2	Homo sapiens	97-102
24333596-10	2014	Our results suggest that PRL-R antagonism in PRL-R over-expressing breast cancer cells may reduce invasion through the redistribution of intracellular Zn pools critical for cellular function.	Zinc	151-153	prolactin receptor	Homo sapiens	25-30
24333596-10	2014	Our results suggest that PRL-R antagonism in PRL-R over-expressing breast cancer cells may reduce invasion through the redistribution of intracellular Zn pools critical for cellular function.	Zinc	151-153	prolactin receptor	Homo sapiens	45-50
24701473-3	2014	Matrix metalloproteinases (MMPs), a class of Zn containing enzymes, are involved in the erosion of the fibrous cap and rupture of the plaque which leads to AMI.	Zinc	45-47	matrix metallopeptidase 2	Homo sapiens	27-31
24405052-3	2014	This idea has been successfully applied to Zn(0.96)Co(0.04)O DMSQDs covered by a shell of ZnS or Ag2S.	Zinc	43-45	angiotensin II receptor type 1	Homo sapiens	97-101
24247244-8	2014	Together, our results show that MoPrP cleavage is far more complex than previously thought and suggest a mechanism by which PrP(C) fragmentation responds to Cu(2+) and Zn(2+).	Zinc	168-170	prion protein	Mus musculus	34-37
24071581-3	2014	We report here the 2.15 A resolution crystal structure of Zn fingers 3-5 of Chaetomium thermophilum Nab2 bound to polyadenosine RNA and establish the structural basis for the molecular recognition of adenosine ribonucleotides.	Zinc	58-60	mRNA-binding protein NAB2	Saccharomyces cerevisiae S288C	100-104
23970781-2	2013	Zn(2+) binding to GH through amino acid residues His18, His21, and Glu174 are essential for GH dimerization and might mediate its aggregation and storage in secretory granules.	Zinc	0-2	gonadotropin releasing hormone receptor	Rattus norvegicus	18-20
23970781-2	2013	Zn(2+) binding to GH through amino acid residues His18, His21, and Glu174 are essential for GH dimerization and might mediate its aggregation and storage in secretory granules.	Zinc	0-2	gonadotropin releasing hormone receptor	Rattus norvegicus	92-94
24076154-4	2013	Expression of rat IAP in Escherichia coli (rIAP-Ec) led to ~200-fold loss of activity that was partially recovered by the addition of external Zn(2+) and Mg(2+) ions.	Zinc	143-145	Cd47 molecule	Rattus norvegicus	18-21
24076154-6	2013	Rat IAP-Ic retains its activity in presence of both Zn(2+) and Mg(2+) whereas activity of most other alkaline phosphatases (APs) including the cIAP was strongly inhibited by excess Zn(2+).	Zinc	52-54	Cd47 molecule	Rattus norvegicus	4-7
24076154-6	2013	Rat IAP-Ic retains its activity in presence of both Zn(2+) and Mg(2+) whereas activity of most other alkaline phosphatases (APs) including the cIAP was strongly inhibited by excess Zn(2+).	Zinc	181-183	Cd47 molecule	Rattus norvegicus	4-7
24187545-4	2013	Transgenic lines expressing HMA4 under the At promoter were always fully complemented for root-to-shoot Zn translocation and developed normally at a 2-muM Zn supply, whereas the lines expressing HMA4 under Nc promoters usually showed only slightly enhanced root to shoot Zn translocation rates in comparison with the double mutant, probably owing to ectopic expression in the roots, respectively.	Zinc	104-106	heavy metal atpase 4	Arabidopsis thaliana	28-32
24187545-4	2013	Transgenic lines expressing HMA4 under the At promoter were always fully complemented for root-to-shoot Zn translocation and developed normally at a 2-muM Zn supply, whereas the lines expressing HMA4 under Nc promoters usually showed only slightly enhanced root to shoot Zn translocation rates in comparison with the double mutant, probably owing to ectopic expression in the roots, respectively.	Zinc	155-157	heavy metal atpase 4	Arabidopsis thaliana	28-32
24187545-4	2013	Transgenic lines expressing HMA4 under the At promoter were always fully complemented for root-to-shoot Zn translocation and developed normally at a 2-muM Zn supply, whereas the lines expressing HMA4 under Nc promoters usually showed only slightly enhanced root to shoot Zn translocation rates in comparison with the double mutant, probably owing to ectopic expression in the roots, respectively.	Zinc	155-157	heavy metal atpase 4	Arabidopsis thaliana	28-32
24187545-5	2013	When expression of the Zn deficiency responsive marker gene ZIP4 was tested, the transgenic lines expressing AtHMA4 under an NcHMA4-1-LC promoter showed on average a 7-fold higher expression in the leaves, in comparison with the double hma2hma4 mutant, showing that this construct aggravated, rather than alleviated the severity of foliar Zn deficiency in the mutant, possible owing to expression in the leaf mesophyll.	Zinc	23-25	heavy metal atpase 4	Arabidopsis thaliana	109-115
23891691-0	2013	Zn(2+) induces apoptosis in human highly metastatic SHG-44 glioma cells, through inhibiting activity of the voltage-gated proton channel Hv1.	Zinc	0-6	hydrogen voltage gated channel 1	Homo sapiens	137-140
23891691-6	2013	The results demonstrated that the inhibition of Hv1 activity via Zn(2+) ions can effectively retard the cancer growth and suppress the cancer metastasis by the decrease of proton extrusion and the down-regulation of gelatinase activity.	Zinc	65-71	hydrogen voltage gated channel 1	Homo sapiens	48-51
23863901-2	2013	One is TLR4, which causes an increase of free zinc ions (Zn(2+)) that is required for the MyD88-dependent expression of inflammatory cytokines.	Zinc	57-59	MYD88 innate immune signal transduction adaptor	Homo sapiens	90-95
23863901-3	2013	This study investigates the role of Zn(2+) on Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF)-dependent signals, the other major intracellular pathway activated by TLR4.	Zinc	36-38	interferon beta 1	Homo sapiens	92-100
23863901-4	2013	Chelation of Zn(2+) with the membrane-permeable chelator N,N,N",N"-Tetrakis(2-pyridylmethyl)ethylenediamine augmented TLR4-mediated production of IFN-beta and subsequent synthesis of inducible NO synthase and production of NO.	Zinc	13-15	interferon beta 1	Homo sapiens	146-154
23863901-8	2013	Taken together, Zn(2+) is specifically involved in TLR signaling, where it differentially regulates MyD88 and TRIF signaling via a zinc signal or via basal Zn(2+) levels, respectively.	Zinc	16-18	MYD88 innate immune signal transduction adaptor	Homo sapiens	100-105
23648111-11	2013	In addition, a UV cross-linking assay followed by Western blotting showed that SRSF6 directly bound to the predicted binding site and Zn(2+) suppressed this binding.	Zinc	134-136	serine and arginine rich splicing factor 6	Homo sapiens	79-84
23648111-12	2013	Moreover, Zn(2+) stimulated SRSF6 hyper-phosphorylation.	Zinc	10-16	serine and arginine rich splicing factor 6	Homo sapiens	28-33
23648111-13	2013	TG003, a cdc2-like kinase inhibitor, partially prevented Zn(2+)-induced generation of BimS and SRSF6 hyper-phosphorylation.	Zinc	57-63	serine and arginine rich splicing factor 6	Homo sapiens	95-100
23648111-14	2013	Taken together, our findings suggest that Zn(2+) inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS.	Zinc	42-48	serine and arginine rich splicing factor 6	Homo sapiens	74-79
23847632-4	2013	In wheat, one member of the NAC (NAM, ATAF, and CUC) transcription factor (TF) family (NAM-B1) has a major role in the process, probably regulating key genes for the early onset of senescence, which results in higher Fe and Zn concentrations in grains.	Zinc	224-226	NAC domain-containing protein 20	Triticum aestivum	33-36
23847632-4	2013	In wheat, one member of the NAC (NAM, ATAF, and CUC) transcription factor (TF) family (NAM-B1) has a major role in the process, probably regulating key genes for the early onset of senescence, which results in higher Fe and Zn concentrations in grains.	Zinc	224-226	NAC domain-containing protein 20	Triticum aestivum	87-90
23761487-4	2013	When heterologously expressed in the yeast mutant zrc1 cot1, OsMTP1 complemented its Zn hypersensitivity and was also localized to the vacuole.	Zinc	85-87	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	50-54
24252376-13	2013	It is likely that any disturbance of Zn buffering by Zip14 and MT3 causes mitochondrial damage and cell death.	Zinc	37-39	solute carrier family 39 member 14	Homo sapiens	53-58
23675870-2	2013	The MAZ serves as a divalent reversible chain-transfer agent for olefin polymerization, resulting in telechelic Zn-metalated polyolefins whose molecular weights are controllable over a wide range.	Zinc	112-114	MYC associated zinc finger protein	Homo sapiens	4-7
23651256-1	2013	Aro80, a member of the Zn(2)Cys(6) family proteins, activates expression of the ARO9 and ARO10 genes involved in catabolism of aromatic amino acids in response to aromatic amino acids that act as inducers.	Zinc	23-25	Aro80p	Saccharomyces cerevisiae S288C	0-5
23651256-1	2013	Aro80, a member of the Zn(2)Cys(6) family proteins, activates expression of the ARO9 and ARO10 genes involved in catabolism of aromatic amino acids in response to aromatic amino acids that act as inducers.	Zinc	23-25	phenylpyruvate decarboxylase ARO10	Saccharomyces cerevisiae S288C	89-94
23905339-6	2013	The 20% and 30% cu-doped Cd1-x Zn, Te films were both p-type conductivity.	Zinc	31-33	CD1c molecule	Homo sapiens	25-28
23137351-3	2013	The remaining three acatalytic isoforms (hCAs VIII, X and XI) lack the active site Zn(2+) and are referred to as CA-related proteins (CA-RPs); however, their function remains elusive.	Zinc	83-85	cytochrome c oxidase subunit 8A	Homo sapiens	41-50
23229024-9	2013	Caspase-3 activity was lower in the ZNS group than in the MPP(+) group.	Zinc	36-39	caspase 3	Rattus norvegicus	0-9
23229024-10	2013	In conclusion, ZNS induced modulator effects on the oxidative stress, intracellular Ca(2+), and the caspase-3 values in an experimental model of Parkinson disease.	Zinc	15-18	caspase 3	Rattus norvegicus	100-109
23387946-2	2013	This study reports the carbon acidities of Calpha and C4" atoms in the Schiff bases of pyridoxal-5"-phosphate (PLP) and pyridoxamine-5"-phosphate (PMP) complexed with several biologically available metal ions (Mg2+, Ni2+, Zn2+, Cu2+, Al3+, and Fe3+).	Zinc	222-226	pyridoxal phosphatase	Homo sapiens	111-114
23149916-4	2013	Our comprehensive analysis revealed allosteric binding (Kd 10-30 nmol/L) to the regulatory Zn(2+) binding domain of HDAC4 that locks the protein in a conformation preventing HDAC4/N-CoR/HDAC3 complex formation.	Zinc	91-97	histone deacetylase 3	Homo sapiens	186-191
23065293-5	2013	At 12 h after the treatment by the appropriate concentrations of L-isoleucine or Zn(2+), the mRNA and protein expressions of porcine beta-defensin 1, 2 and 3 were increased (P &lt; 0.05), and reached their maximum after treatment with 25 or 100 mumol/mL zinc sulfate and 25 or 50 mug/mL isoleucine (P &lt; 0.05).	Zinc	81-83	beta-defensin 1	Sus scrofa	133-157
23195954-3	2013	Analogous to the active site of Zn(2+) carboxypeptidases, calnuc has two high affinity (K(d) ~ 20 nm), well conserved Zn(2+)-binding sites near its N terminus, although it is inactive as a peptidase.	Zinc	32-34	nucleobindin 1	Homo sapiens	58-64
23195954-3	2013	Analogous to the active site of Zn(2+) carboxypeptidases, calnuc has two high affinity (K(d) ~ 20 nm), well conserved Zn(2+)-binding sites near its N terminus, although it is inactive as a peptidase.	Zinc	32-38	nucleobindin 1	Homo sapiens	58-64
23195954-4	2013	Zn(2+) binding allosterically and negatively regulates the serine protease activity of calnuc, inhibition being caused by an "open to close" change in its conformation not seen upon Ca(2+) binding.	Zinc	0-6	nucleobindin 1	Homo sapiens	87-93
23195954-7	2013	Calnuc, therefore, exists dynamically in two different forms, (i) as a Ca(2+)-binding protein in Zn(2+)-bound form and (ii) as a protease in Zn(2+)-free form, commissioning it to perform multiple functions.	Zinc	97-103	nucleobindin 1	Homo sapiens	0-6
23195954-7	2013	Calnuc, therefore, exists dynamically in two different forms, (i) as a Ca(2+)-binding protein in Zn(2+)-bound form and (ii) as a protease in Zn(2+)-free form, commissioning it to perform multiple functions.	Zinc	141-147	nucleobindin 1	Homo sapiens	0-6
23945099-1	2013	Structural features, synthesis, and reactivity of Zn-biphenyl metal-organic frameworks with MOF-5 topology are presented to show the chemical flexibility of such materials and to demonstrate the challenges that can be encountered and solved to avoid interpenetration.	Zinc	50-52	lysine acetyltransferase 8	Homo sapiens	92-95
23264639-5	2013	In yeast, AtZIP1 and AtZIP2 both complemented the Zn and Mn uptake mutants, suggesting that they both may transport Zn and/or Mn.	Zinc	50-52	zinc transporter 1 precursor	Arabidopsis thaliana	10-16
23264639-5	2013	In yeast, AtZIP1 and AtZIP2 both complemented the Zn and Mn uptake mutants, suggesting that they both may transport Zn and/or Mn.	Zinc	116-118	zinc transporter 1 precursor	Arabidopsis thaliana	10-16
23264639-8	2013	Functional studies with Arabidopsis AtZIP1 and AtZIP2 T-DNA knockout lines suggest that both transporters play a role in Mn (and possibly Zn) translocation from the root to the shoot.	Zinc	138-140	zinc transporter 1 precursor	Arabidopsis thaliana	36-42
23990800-2	2013	Naturally selected metal hypertolerance and extraordinarily high leaf metal accumulation in A. halleri both require Heavy Metal ATPase4 (HMA4) encoding a PIB-type ATPase that pumps Zn(2+) and Cd(2+) out of specific cell types.	Zinc	181-183	heavy metal atpase 4	Arabidopsis thaliana	137-141
24189560-5	2013	Moreover, Zn(2+) uptake activity into cellular cytosol and the mRNA expression of zinc transporters, ZIP6 and ZIP10, in the high glucose-exposed cells were shown to be especially higher than in the physiological glucose level.	Zinc	10-16	solute carrier family 39 member 10	Homo sapiens	110-115
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	31-33	solute carrier family 39 member 10	Homo sapiens	169-174
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	137-139	solute carrier family 39 member 10	Homo sapiens	68-73
24189560-6	2013	The depletion of intracellular Zn(2+) by zinc chelation and ZIP6 or ZIP10 knockdown blocked the high migration activity, indicating that Zn(2+) transported via ZIP6 and ZIP10 plays an essential role in the promotion of cell motility stimulated in high glucose level.	Zinc	137-139	solute carrier family 39 member 10	Homo sapiens	169-174
23116444-11	2012	Our results suggest that the relaxing effects of Zn2+ on cardiomyocyte function are more pronounced in the HG state due an insulin-dependent effect of enhancing removal of cytosolic Ca2+ via SERCA2a or NCX or by reducing Ca2+ influx via L-type channel or Ca2+ leak through the RyR.	Zinc	49-53	ryanodine receptor 2	Rattus norvegicus	277-280
22957890-1	2012	Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM).	Zinc	91-97	C-C motif chemokine receptor 1	Homo sapiens	36-40
22957890-1	2012	Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM).	Zinc	91-97	C-C motif chemokine receptor 4	Homo sapiens	42-46
22957890-4	2012	A screening of 20 chelator analogues in complex with Zn(II) identified compounds with increased potencies, with 7 reaching highest potency at CCR1 (EC(50) of 0.85 muM), 20 at CCR8 (0.39 muM), and 8 at CCR5 (1.0 muM).	Zinc	53-55	C-C motif chemokine receptor 1	Homo sapiens	142-146
22992416-0	2012	Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar rat after feeding modified poultry egg.	Zinc	15-17	leptin	Rattus norvegicus	31-37
22992416-5	2012	In the present study, the efficacy of ME verses conventional egg (CE) was tested on Zn-induced leptin resistance in rat model to ascertain if the supplementation of antioxidants in the form of egg can reverse Zn-induced leptin resistance to leptin sensitive state.	Zinc	84-86	leptin	Rattus norvegicus	95-101
22992416-5	2012	In the present study, the efficacy of ME verses conventional egg (CE) was tested on Zn-induced leptin resistance in rat model to ascertain if the supplementation of antioxidants in the form of egg can reverse Zn-induced leptin resistance to leptin sensitive state.	Zinc	209-211	leptin	Rattus norvegicus	220-226
22992416-5	2012	In the present study, the efficacy of ME verses conventional egg (CE) was tested on Zn-induced leptin resistance in rat model to ascertain if the supplementation of antioxidants in the form of egg can reverse Zn-induced leptin resistance to leptin sensitive state.	Zinc	209-211	leptin	Rattus norvegicus	220-226
22992416-9	2012	RESULTS: The results revealed that food intake, gain in body weight, height and number/unit surface area of intestinal microvillus and serum leptin, glucose, insulin and cortisol were higher in CE and Zn-HL-Diet treated groups; serum Zn, Cu, Mg were higher and Cu and Mg in tissues were lower in them than the control group.	Zinc	201-203	leptin	Rattus norvegicus	141-147
22992416-12	2012	CONCLUSION: The data suggest that Zn-induced leptin resistance can be attenuated through restoring the ionic balance of Zn, Cu and Mg through inclusion of antioxidants in diet such as these modified eggs.	Zinc	34-36	leptin	Rattus norvegicus	45-51
22992416-12	2012	CONCLUSION: The data suggest that Zn-induced leptin resistance can be attenuated through restoring the ionic balance of Zn, Cu and Mg through inclusion of antioxidants in diet such as these modified eggs.	Zinc	120-122	leptin	Rattus norvegicus	45-51
22843691-1	2012	Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca(2+))- and zinc (Zn(2+))-permeable ion channels that sense noxious substances.	Zinc	88-94	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-45
22843691-1	2012	Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca(2+))- and zinc (Zn(2+))-permeable ion channels that sense noxious substances.	Zinc	88-94	transient receptor potential cation channel subfamily A member 1	Homo sapiens	47-52
22843691-6	2012	The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8.	Zinc	99-101	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
22825026-0	2012	[(eta2-(Si/Ge)4)Zn(eta2-(Si/Ge)4)](6-)- novel Zintl clusters with mixed Si/Ge tetrahedra bridged by a Zn atom.	Zinc	16-18	DNA polymerase iota	Homo sapiens	2-6
22825026-0	2012	[(eta2-(Si/Ge)4)Zn(eta2-(Si/Ge)4)](6-)- novel Zintl clusters with mixed Si/Ge tetrahedra bridged by a Zn atom.	Zinc	16-18	DNA polymerase iota	Homo sapiens	19-23
22727028-5	2012	Additional interactions with the Zn(2+) -binding site close to the catalytic centre and the catalytic centre itself in the C3 domain of CAD were detected, suggesting that prevention of CAD homodimerization and local structural perturbation or blocking of the active site together constitute a dual inhibitory mechanism to effectively inhibit CAD.	Zinc	33-39	DNA fragmentation factor subunit beta	Homo sapiens	136-139
22727028-5	2012	Additional interactions with the Zn(2+) -binding site close to the catalytic centre and the catalytic centre itself in the C3 domain of CAD were detected, suggesting that prevention of CAD homodimerization and local structural perturbation or blocking of the active site together constitute a dual inhibitory mechanism to effectively inhibit CAD.	Zinc	33-39	DNA fragmentation factor subunit beta	Homo sapiens	185-188
22727028-5	2012	Additional interactions with the Zn(2+) -binding site close to the catalytic centre and the catalytic centre itself in the C3 domain of CAD were detected, suggesting that prevention of CAD homodimerization and local structural perturbation or blocking of the active site together constitute a dual inhibitory mechanism to effectively inhibit CAD.	Zinc	33-39	DNA fragmentation factor subunit beta	Homo sapiens	185-188
22651379-7	2012	Additionally, both HL1 and HL2 exhibit an important selectivity for Cu(2+) over Zn(2+).	Zinc	80-82	intelectin 2	Homo sapiens	27-30
22556412-7	2012	The inhibition of intrinsic AID enzymatic activity by Fe(2+) was specific, as shown by lack of inhibition of AID-mediated dC deamination by other bivalent metal ions, such as Zn(2+), Mn(2+), Mg(2+), or Ni(2+), and the inability of Fe(2+) to inhibit UNG-mediated dU excision.	Zinc	175-177	activation induced cytidine deaminase	Homo sapiens	28-31
22411188-2	2012	Adapting findings from the literature of Zn(II) ion sensors, we previously reported chelating sulfonamide inhibitors of MMP-2, some of which showed excellent selectivity over other gelatinases (MMP-9).	Zinc	41-47	matrix metallopeptidase 2	Homo sapiens	120-125
22102510-7	2012	We found that Ca(2+) or Zn(2+) entry via the transient receptor potential melastatin 7 (TRPM7) channel was attenuated by the presence of FAD-associated PS1 mutants, such as DeltaE9 and L286V.	Zinc	24-26	presenilin 1	Homo sapiens	152-155
22441041-14	2012	These results suggest that SNARE proteins are necessary for the increased activity of KCC2 after Zn(2+) stimulation of mZnR/GPR39.	Zinc	97-103	G protein-coupled receptor 39	Rattus norvegicus	124-129
22339672-5	2012	The pH(i) drop reduced the affinity of FluoZin-3 and Fura-2-FF for Zn2+.	Zinc	67-71	glucose-6-phosphate isomerase	Homo sapiens	4-9
22339672-9	2012	Inhibiting the mechanisms responsible for the Ca2+-dependent pH(i) drop (plasmalemmal Ca2+ pump and mitochondria) counteracted the Glu/Gly-induced intracellular Zn2+ release.	Zinc	161-165	glucose-6-phosphate isomerase	Homo sapiens	61-66
22339672-11	2012	A pH(i) drop to 6.0 (without any Ca2+ influx or glutamate receptor activation) led to intracellular Zn2+ release; the released Zn2+ (free Zn2+ plus Zn2+) bound to Fura-2FF and FluoZin-3) reached 1 muM.	Zinc	100-104	glucose-6-phosphate isomerase	Homo sapiens	2-7
22339672-11	2012	A pH(i) drop to 6.0 (without any Ca2+ influx or glutamate receptor activation) led to intracellular Zn2+ release; the released Zn2+ (free Zn2+ plus Zn2+) bound to Fura-2FF and FluoZin-3) reached 1 muM.	Zinc	127-131	glucose-6-phosphate isomerase	Homo sapiens	2-7
22339672-11	2012	A pH(i) drop to 6.0 (without any Ca2+ influx or glutamate receptor activation) led to intracellular Zn2+ release; the released Zn2+ (free Zn2+ plus Zn2+) bound to Fura-2FF and FluoZin-3) reached 1 muM.	Zinc	127-131	glucose-6-phosphate isomerase	Homo sapiens	2-7
22339672-11	2012	A pH(i) drop to 6.0 (without any Ca2+ influx or glutamate receptor activation) led to intracellular Zn2+ release; the released Zn2+ (free Zn2+ plus Zn2+) bound to Fura-2FF and FluoZin-3) reached 1 muM.	Zinc	127-131	glucose-6-phosphate isomerase	Homo sapiens	2-7
22186160-2	2012	The formation of Zn-doped HAp was achieved above 900 C only.	Zinc	17-19	reticulon 3	Homo sapiens	26-29
22186160-3	2012	Zn-doped HAp has the Ca(10)Zn(x)(PO(4))(6)(OH)(2-2)(x)O(2)(x) (0&lt;x&lt;=0.25) chemical composition with a constant Ca/P ratio of 1.67 due to the insertion mechanism into the hexagonal channel (partial occupancy of the 2b Wyckoff site with the formation of linear O-Zn-O entities).	Zinc	0-2	reticulon 3	Homo sapiens	9-12
22186160-5	2012	The reversible formation of Zn-doped beta-TCP phase was observed at 600 C, reached its maximum content at 900 C and had almost vanished at 1100 C. The results presented here strengthen the recently described mechanism of Zn insertion in the interstitial 2b Wyckoff position of the HAp structure, and explain the origin of the contradictory reports in the corresponding literature.	Zinc	28-30	reticulon 3	Homo sapiens	281-284
22186160-5	2012	The reversible formation of Zn-doped beta-TCP phase was observed at 600 C, reached its maximum content at 900 C and had almost vanished at 1100 C. The results presented here strengthen the recently described mechanism of Zn insertion in the interstitial 2b Wyckoff position of the HAp structure, and explain the origin of the contradictory reports in the corresponding literature.	Zinc	221-223	reticulon 3	Homo sapiens	281-284
21918843-7	2012	For the metallovariants, cleavage of the peptide bond occurs in the rate-limiting step with barriers of 17.8, 18.0, and 24.2 kcal/mol for the Zn1-Zn2, Mg1-Zn2, and Mg1-Co2 enzymes, respectively.	Zinc	146-149	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	164-167
22148364-6	2012	For the ZnO/ZnS core/shell nanostructures, the J(SC) and eta can reach a maximum of 8.38 mA/cm(2) and 1.92% after 6 h conversion time, corresponding to 12- and 16-fold increments of as-synthesized ZnO, respectively.	Zinc	12-15	endothelin receptor type A	Homo sapiens	57-60
22536213-1	2012	Zinc (Zn(2+)) appears to be intimately involved in insulin metabolism since insulin secretion is correlated with zinc secretion in response to glucose stimulation, but little is known about the regulation of zinc homeostasis in pancreatic beta-cells.	Zinc	6-12	insulin	Mesocricetus auratus	51-58
21880076-5	2012	Recombinant IDEF1 protein expressed in Escherichia coli contained mainly Fe and Zn.	Zinc	80-82	HvIDEF1	Hordeum vulgare	12-17
22880063-0	2012	HvHMA2, a P(1B)-ATPase from barley, is highly conserved among cereals and functions in Zn and Cd transport.	Zinc	87-89	HMA2	Hordeum vulgare	0-6
22880063-8	2012	Heterologous expression in Saccharomyces cerevisiae demonstrates that HvHMA2 functions as a Zn and Cd pump.	Zinc	92-94	HMA2	Hordeum vulgare	70-76
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	33-35	HMA2	Hordeum vulgare	0-6
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	33-35	HMA2	Hordeum vulgare	107-113
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	129-131	HMA2	Hordeum vulgare	0-6
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	129-131	HMA2	Hordeum vulgare	107-113
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	129-131	HMA2	Hordeum vulgare	0-6
22880063-10	2012	HvHMA2 expression suppresses the Zn-deficient phenotype of the Arabidopsis hma2hma4 mutant indicating that HvHMA2 functions as a Zn pump in planta and could play a role in root to shoot Zn transport.	Zinc	129-131	HMA2	Hordeum vulgare	107-113
22125264-1	2012	The GDI1 protein related vesicle transport system was studied to investigate the possibility that an exclusion of toxic zinc (Zn) from the cytoplasm ameliorates Zn toxicity in Saccharomyces cerevisiae (yeast).	Zinc	126-128	Gdi1p	Saccharomyces cerevisiae S288C	4-8
22125264-1	2012	The GDI1 protein related vesicle transport system was studied to investigate the possibility that an exclusion of toxic zinc (Zn) from the cytoplasm ameliorates Zn toxicity in Saccharomyces cerevisiae (yeast).	Zinc	161-163	Gdi1p	Saccharomyces cerevisiae S288C	4-8
22125264-2	2012	A temperature-sensitive gdi1 mutant (originally called sec19), in which the GDP dissociation inhibitor becomes inactive at the non-permissive temperature (37  C), was more sensitive to Zn than its parental GDI1 strain at 32  C (a moderately non-permissive temperature).	Zinc	185-187	Gdi1p	Saccharomyces cerevisiae S288C	24-28
22125264-3	2012	The relative efflux of cytoplasmic Zn in the gdi1 mutant was lower than that in the control strain.	Zinc	35-37	Gdi1p	Saccharomyces cerevisiae S288C	45-49
22125264-5	2012	It is therefore suggested that the GDI1-related vesicle transport system contributes to Zn tolerance in yeast.	Zinc	88-90	Gdi1p	Saccharomyces cerevisiae S288C	35-39
22125264-6	2012	Furthermore, changes in the number of Zn-specific fluorescent granules (zincosomes) were observed by zinquin staining in the mutant cells under Zn treatment at 32  C and 37  C. We concluded that the GDI1 protein is implicated in control of vesicle numbers.	Zinc	38-40	Gdi1p	Saccharomyces cerevisiae S288C	199-203
22125264-6	2012	Furthermore, changes in the number of Zn-specific fluorescent granules (zincosomes) were observed by zinquin staining in the mutant cells under Zn treatment at 32  C and 37  C. We concluded that the GDI1 protein is implicated in control of vesicle numbers.	Zinc	144-146	Gdi1p	Saccharomyces cerevisiae S288C	199-203
22125264-7	2012	Collectively, the results suggest that the GDI1protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content, allowing yeast to survive in the presence of toxic Zn.	Zinc	70-72	Gdi1p	Saccharomyces cerevisiae S288C	43-47
22125264-7	2012	Collectively, the results suggest that the GDI1protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content, allowing yeast to survive in the presence of toxic Zn.	Zinc	156-158	Gdi1p	Saccharomyces cerevisiae S288C	43-47
22125264-7	2012	Collectively, the results suggest that the GDI1protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content, allowing yeast to survive in the presence of toxic Zn.	Zinc	156-158	Gdi1p	Saccharomyces cerevisiae S288C	43-47
21996590-5	2011	The model calculations predicted pseudo octahedral trans-[M(CCA2)(2)(H(2)O)(2)] structures for the Zn(II), Ni(II) and Co(II) complexes and a binuclear [Mn(2)(CCA2)(4)(H(2)O)(2)] structure.	Zinc	99-101	crystallin beta B2	Homo sapiens	60-64
21864503-9	2011	The data collected indicate that the entry of Zn2+ through TRPC6 channels can up-regulate the size of the DTDP-sensitive pool of Zn2+.	Zinc	46-50	transient receptor potential cation channel subfamily C member 6	Homo sapiens	59-64
21864503-9	2011	The data collected indicate that the entry of Zn2+ through TRPC6 channels can up-regulate the size of the DTDP-sensitive pool of Zn2+.	Zinc	129-133	transient receptor potential cation channel subfamily C member 6	Homo sapiens	59-64
21864503-10	2011	By showing that TRPC6 channels constitute a Zn2+ entry pathway, our study suggests that they could play a role in zinc homeostasis.	Zinc	44-48	transient receptor potential cation channel subfamily C member 6	Homo sapiens	16-21
21653899-4	2011	Zip14-mediated (55)Fe(2+) uptake was saturable (K(0.5)   2 muM), temperature-dependent (apparent activation energy, E(a) = 15 kcal/mol), pH-sensitive, Ca(2+)-dependent, and inhibited by Co(2+), Mn(2+), and Zn(2+).	Zinc	206-212	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-5
21653899-7	2011	Zip14 also mediated the uptake of (109)Cd(2+), (54)Mn(2+), and (65)Zn(2+) but not (64)Cu (I or II).	Zinc	67-69	solute carrier family 39 (zinc transporter), member 14	Mus musculus	0-5
21660051-5	2011	Silencing of GSK-3beta or p53 expression was cardioprotective, indicating that activation of the ERK-GSK-3beta-p53 signaling pathway is involved in Zn(2+)-sensitive myocyte death.	Zinc	148-150	glycogen synthase kinase 3 beta	Homo sapiens	13-22
21660051-5	2011	Silencing of GSK-3beta or p53 expression was cardioprotective, indicating that activation of the ERK-GSK-3beta-p53 signaling pathway is involved in Zn(2+)-sensitive myocyte death.	Zinc	148-150	glycogen synthase kinase 3 beta	Homo sapiens	101-110
21777051-2	2011	Additionally, Zn-induced alterations in the neurobehavioral parameters, lipid peroxidation (LPO), striatal dopamine and its metabolites and tyrosine hydroxylase (TH) protein expression were measured to assess their correlations with the oxidative stress.	Zinc	14-16	tyrosine hydroxylase	Rattus norvegicus	140-160
21777051-3	2011	Zn exposure reduced the locomotor activity, rotarod performance, striatal dopamine and its metabolites and TH protein expression.	Zinc	0-2	tyrosine hydroxylase	Rattus norvegicus	107-109
22068497-4	2011	The recombinant MaeB showed a maximum activity at pH 7.8 and 46 C. MaeB activity was dependent on the presence of Mn(2+) but was strongly inhibited by Zn(2+).	Zinc	151-153	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))	Escherichia coli str. K-12 substr. MG1655	67-71
21593480-6	2011	An increase in CRISP1 was detected in sperm exposed to Zn(2+), but not if the cation was added with ethylenediaminetetra-acetic acid (EDTA).	Zinc	55-57	cysteine-rich secretory protein 3	Rattus norvegicus	15-21
21593480-8	2011	Association of CRISP1 with sperm was dependent on epididymal fluid and Zn(2+) concentrations and incubation time.	Zinc	71-77	cysteine-rich secretory protein 3	Rattus norvegicus	15-21
21593480-10	2011	Flow cytometry of caput sperm exposed to biotinylated CRISP1/avidin-fluorescein isothiocyanate revealed that only the cells incubated with Zn(2+) exhibited an increase in fluorescence.	Zinc	139-141	cysteine-rich secretory protein 3	Rattus norvegicus	54-60
21593480-12	2011	Detection of changes in the tryptophan fluorescence emission spectra of CRISP1 when exposed to Zn(2+) supported a direct interaction between CRISP1 and Zn(2+).	Zinc	95-97	cysteine-rich secretory protein 3	Rattus norvegicus	72-78
21593480-12	2011	Detection of changes in the tryptophan fluorescence emission spectra of CRISP1 when exposed to Zn(2+) supported a direct interaction between CRISP1 and Zn(2+).	Zinc	95-97	cysteine-rich secretory protein 3	Rattus norvegicus	141-147
21593480-12	2011	Detection of changes in the tryptophan fluorescence emission spectra of CRISP1 when exposed to Zn(2+) supported a direct interaction between CRISP1 and Zn(2+).	Zinc	152-154	cysteine-rich secretory protein 3	Rattus norvegicus	72-78
21593480-12	2011	Detection of changes in the tryptophan fluorescence emission spectra of CRISP1 when exposed to Zn(2+) supported a direct interaction between CRISP1 and Zn(2+).	Zinc	152-154	cysteine-rich secretory protein 3	Rattus norvegicus	141-147
21593480-13	2011	Incubation of either cauda epididymal fluid or purified CRISP1 with Zn(2+), followed by native-PAGE and Western blot analysis, revealed the presence of high-molecular-weight CRISP1 complexes not detected in fluids treated with EDTA.	Zinc	68-70	cysteine-rich secretory protein 3	Rattus norvegicus	56-62
21593480-13	2011	Incubation of either cauda epididymal fluid or purified CRISP1 with Zn(2+), followed by native-PAGE and Western blot analysis, revealed the presence of high-molecular-weight CRISP1 complexes not detected in fluids treated with EDTA.	Zinc	68-70	cysteine-rich secretory protein 3	Rattus norvegicus	174-180
21766873-2	2011	In this work, we demonstrate that the electrostatic and chemical (complexing and gold-thiol bonding) interactions existing in a gold nanoparticle/Zn(2+)/dithiothreitol-based ternary chemical system is "programmable" and can be utilized to regulate the aggregation and dispersion of nanoparticles via XOR and INHIBIT logics.	Zinc	146-152	xanthine dehydrogenase	Homo sapiens	300-303
20857495-3	2011	By contrast, Cox-2 deletion offers protection in Zn-sufficient (ZS) mice.	Zinc	49-51	prostaglandin-endoperoxide synthase 2	Mus musculus	13-18
20857495-11	2011	Zn-replenishment in ZD:Cox-2(-/-) mice reversed the inflammation and inhibited carcinogenesis.	Zinc	0-2	prostaglandin-endoperoxide synthase 2	Mus musculus	23-28
21934214-4	2011	Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix.	Zinc	72-74	matrix metallopeptidase 2	Homo sapiens	27-31
21417258-4	2011	Here we show that binding of human gammaD-crystallin (HGD, a natural substrate) to human alphaA-crystallin (HAA) is inversely related to the binding of Cu2+/Zn2+ ions: The higher the amount of bound HGD, the lower the amount of bound metal ions.	Zinc	157-161	crystallin gamma D	Homo sapiens	35-52
21237246-7	2011	The S(328)A mutant mimics the sequence of bovine Ap-B Zn(2+)-binding site, which differs from those of other mammalian Ap-B.	Zinc	54-60	arginyl aminopeptidase	Bos taurus	49-53
21245412-9	2011	Immunohistochemical analysis of carcinomas showed that Zn supplementation caused a shift to a less proliferative/aggressive cancer phenotype by reducing cell proliferation, stimulating apoptosis and decreasing expression of the key tumor markers cyclin D1, p53 and COX-2.	Zinc	55-57	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	265-270
21847988-7	2011	AtCAX3 is the mainly Ca2+/H+ transporter in response to salt stress; AtCAX2 and AtCAX4 participate in transportation and detoxicification of heavy metal ions (Cd2+, Zn2+, and Mn2+) in cells under heavy metal stress, and impact root/shoot Cd partitioning in plant.	Zinc	165-169	cation exchanger 2	Arabidopsis thaliana	69-75
21392374-3	2011	The main structural difference between archaeal MBF1 (aMBF1) and eukaryotic MBF1 is the presence of a Zn ribbon motif in aMBF1.	Zinc	102-104	multiprotein-bridging factor 1	Saccharomyces cerevisiae S288C	48-52
21392374-3	2011	The main structural difference between archaeal MBF1 (aMBF1) and eukaryotic MBF1 is the presence of a Zn ribbon motif in aMBF1.	Zinc	102-104	multiprotein-bridging factor 1	Saccharomyces cerevisiae S288C	55-59
21205077-1	2011	The enzyme aminopeptidase N (APN, also known as CD13) is a Zn(2+) dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid.	Zinc	59-61	alanyl aminopeptidase, membrane	Homo sapiens	11-27
21205077-1	2011	The enzyme aminopeptidase N (APN, also known as CD13) is a Zn(2+) dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid.	Zinc	59-61	alanyl aminopeptidase, membrane	Homo sapiens	29-32
21205077-1	2011	The enzyme aminopeptidase N (APN, also known as CD13) is a Zn(2+) dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid.	Zinc	59-61	alanyl aminopeptidase, membrane	Homo sapiens	48-52
21413179-8	2011	Our results show that this Hg20 detection method has excellent selectivity over other divalent metal ions (e.g. Pb(2+), Cu(2+), Mn(2+), Co(2+), Zn(2+), Cd(2+), Mg(2+), Ca(2+), and Ba(2+)).	Zinc	144-146	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	27-31
22164158-4	2011	It is concluded that GPR39 functions in a beta-cell protective manner and it is suggested that it is involved in some of the beneficial, beta-cell protective effects observed for Zn(++) and that GPR39 may be a target for antidiabetic drug intervention.	Zinc	179-181	G protein-coupled receptor 39	Mus musculus	21-26
21790058-6	2011	Zn supplementation, at low level, restored and enhanced the functional activity of these enzymes (SOD, CAT, APX and GR) as compared to Cd-alone-treated plants.	Zinc	0-2	catalase isozyme 1	Solanum lycopersicum	103-106
21790058-6	2011	Zn supplementation, at low level, restored and enhanced the functional activity of these enzymes (SOD, CAT, APX and GR) as compared to Cd-alone-treated plants.	Zinc	0-2	glutathione reductase	Solanum lycopersicum	116-118
21446559-2	2011	ZnO/M-FAU was prepared by exposing Er(3+)- or Ca(2+)-exchanged Na-FAU to Zn vapor and to air at 723 K. The ZnO formation in the M-FAU showed a change in intensity in the (220), (311) and (331) lines, but no indication of ZnO peaks.	Zinc	0-2	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	6-9
21446559-2	2011	ZnO/M-FAU was prepared by exposing Er(3+)- or Ca(2+)-exchanged Na-FAU to Zn vapor and to air at 723 K. The ZnO formation in the M-FAU showed a change in intensity in the (220), (311) and (331) lines, but no indication of ZnO peaks.	Zinc	0-2	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	66-69
21446559-2	2011	ZnO/M-FAU was prepared by exposing Er(3+)- or Ca(2+)-exchanged Na-FAU to Zn vapor and to air at 723 K. The ZnO formation in the M-FAU showed a change in intensity in the (220), (311) and (331) lines, but no indication of ZnO peaks.	Zinc	0-2	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	66-69
21738593-2	2011	In yeast, Mg uptake is primarily mediated by the Alr1 transporter, which also allows low affinity uptake of other divalent cations such as Ni(2+), Mn(2+), Zn(2+) and Co(2+).	Zinc	155-157	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	49-53
21138269-17	2010	Structural requirements for creation of the new Zn(2+) site in nNOS were analyzed in detail.	Zinc	48-50	nitric oxide synthase 1	Homo sapiens	63-67
20815357-0	2010	The role of Zn2+ on the structure and stability of murine adenosine deaminase.	Zinc	12-16	adenosine deaminase	Mus musculus	58-77
20815357-3	2010	In this study, we have investigated the role of Zn(2+) with respect to ADA structure and stability.	Zinc	48-50	adenosine deaminase	Mus musculus	71-74
20815357-7	2010	ADA contains four tryptophan residues distant from the Zn(2+) site.	Zinc	55-61	adenosine deaminase	Mus musculus	0-3
21589287-2	2010	Given that the Zn-O interactions [2.4926 (15) and 2.6673 (15) A] can be considered as weakly bonding and the nitrate ions share the same C(2) axis of the Zn(dpp)(2) fragment (dpp is 4,7-diphenyl-1,10-phenanthroline), these anions belong to the coordination sphere of Zn(2+), leading to a complex with an overall coordination number of 8 for the metal ion.	Zinc	154-156	dentin sialophosphoprotein	Homo sapiens	157-160
21044600-2	2010	Furthermore, divalent transition metal ions, especially Zn(2+) and Cu(2+), seem to directly affect the MBP-mediated formation and stabilization of the myelin sheath of the central nervous system.	Zinc	56-58	myelin basic protein	Homo sapiens	103-106
21044600-4	2010	Here, using standard continuous wave and modern pulse electron paramagnetic resonance methods, as well as dynamic light scattering, we demonstrate the uptake and specific coordination of two Cu(2+) atoms or one Zn(2+) atom per MBP molecule in solution.	Zinc	211-213	myelin basic protein	Homo sapiens	227-230
21044600-5	2010	In the presence of phosphates, further addition of divalent metal ions above a characteristic threshold of four Cu(2+) atoms or two Zn(2+) atoms per MBP molecule leads to the formation of large MBP aggregates within the protein solution.	Zinc	132-134	myelin basic protein	Homo sapiens	149-152
21044600-5	2010	In the presence of phosphates, further addition of divalent metal ions above a characteristic threshold of four Cu(2+) atoms or two Zn(2+) atoms per MBP molecule leads to the formation of large MBP aggregates within the protein solution.	Zinc	132-134	myelin basic protein	Homo sapiens	194-197
20975991-3	2010	PRINCIPAL FINDINGS: The Arabidopsis hma2 hma4 mutant has a stunted phenotype and a distinctive ionomic profile, with low shoot levels of Zn, Cd, Co, K and Rb, and high shoot Cu.	Zinc	137-139	heavy metal atpase 4	Arabidopsis thaliana	41-45
20975991-5	2010	AtHMA4-FL expression rescued Co, K, Rb and Cu to wild-type levels, and partially returned Cd and Zn levels (83% and 28% of wild type respectively).	Zinc	97-99	heavy metal atpase 4	Arabidopsis thaliana	0-6
20975991-9	2010	When expressed in yeast, AtHMA4-C-term and AtHMA4-trunc conferred greater Cd and Zn tolerance than AtHMA4-FL.	Zinc	81-83	heavy metal atpase 4	Arabidopsis thaliana	25-31
20975991-9	2010	When expressed in yeast, AtHMA4-C-term and AtHMA4-trunc conferred greater Cd and Zn tolerance than AtHMA4-FL.	Zinc	81-83	heavy metal atpase 4	Arabidopsis thaliana	43-49
20975991-9	2010	When expressed in yeast, AtHMA4-C-term and AtHMA4-trunc conferred greater Cd and Zn tolerance than AtHMA4-FL.	Zinc	81-83	heavy metal atpase 4	Arabidopsis thaliana	43-49
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	121-123	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	37-41
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	121-123	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	48-53
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	121-123	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	171-176
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	200-202	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	37-41
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	200-202	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	48-53
20889130-3	2010	We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation in dTRPM disrupts intracellular Zn(2+) homeostasis.	Zinc	200-202	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	171-176
20889130-7	2010	Thus our results implicate TRPM channels in the regulation of cellular Zn(2+) in vivo.	Zinc	71-73	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	27-31
20889130-8	2010	We propose that regulation of Zn(2+) homeostasis through dTRPM channels is required to support molecular processes that mediate class I PI3K-regulated cell growth.	Zinc	30-36	Transient receptor potential cation channel, subfamily M	Drosophila melanogaster	57-62
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	0-6	hydroxyacylglutathione hydrolase	Homo sapiens	20-24
20715794-6	2010	Zn(II)-loaded R246H GLX2-1 enzyme bound 2 equiv of Zn(II), and (1)H NMR spectra of the Co(II)-substituted analogue of this enzyme strongly suggest that the introduced histidine binds to Co(II).	Zinc	51-57	hydroxyacylglutathione hydrolase	Homo sapiens	20-24
20498861-1	2010	A Zn-MOF assembled from a new C(2h)-symmetric terphenyl dicarboxylate and DABCO was prepared and characterized by X-ray crystallography and gas sorption analysis: a preferential sorption of CO(2) over N(2) and H(2) was observed with an exceptionally high CO(2) adsorption enthalpy.	Zinc	2-4	lysine acetyltransferase 8	Homo sapiens	5-8
20426397-1	2010	The redox properties of Fe and Zn complexes coordinated by an alpha-diimine based N(4)-macrocyclic ligand (TIM) have been examined using spectroscopic methods and density functional theory (DFT) computational analysis.	Zinc	31-33	Rho guanine nucleotide exchange factor 5	Homo sapiens	107-110
19944784-1	2010	The atomic level mechanism of incorporation of Zn(2+) into hydroxyapatite (HAp), which is a potential dopant to promote bone formation, was investigated, based on first principles total energy calculations and experimental X-ray absorption near edge structure (XANES) analyses.	Zinc	47-53	reticulon 3	Homo sapiens	75-78
19944784-2	2010	It was found that Zn(2+)-doped HAp tends to have a Ca-deficient chemical composition and substitutional Zn(2+) ions are associated with a defect complex with a Ca(2+) vacancy and two charge compensating protons.	Zinc	18-20	reticulon 3	Homo sapiens	31-34
19944784-2	2010	It was found that Zn(2+)-doped HAp tends to have a Ca-deficient chemical composition and substitutional Zn(2+) ions are associated with a defect complex with a Ca(2+) vacancy and two charge compensating protons.	Zinc	104-106	reticulon 3	Homo sapiens	31-34
19944784-3	2010	Moreover, first principles calculations demonstrated that Zn(2+) incorporation into HAp can take place by occupying the Ca(2+) vacancy of the defect complex.	Zinc	58-64	reticulon 3	Homo sapiens	84-87
20397684-8	2010	Results of optical property calculations for the Zn and Mg phases revealed SHG responses of approximately 5.3 and 4.7 times of KDP, respectively, the order of Zn &gt; Mg is in good agreement with the experiment data.	Zinc	49-51	WNK lysine deficient protein kinase 1	Homo sapiens	127-130
20100538-7	2010	ICP-AES measurements showed that Akbu-LAAO contains four Zn(2+) per dimer that are unessential for the hydrolytic activity of the enzyme.	Zinc	57-59	interleukin 4 induced 1	Homo sapiens	38-42
20100538-8	2010	The emission fluorescence intensity of Akbu-LAAO decreases by 61% on removal of Zn(2+) indicating that the zinc probably helps maintain the structural integrity of the enzyme.	Zinc	80-86	interleukin 4 induced 1	Homo sapiens	44-48
20104313-3	2010	Traces of the Ru complex induce the Zn complex to crystallize in the Pcca modification.	Zinc	36-38	propionyl-CoA carboxylase subunit alpha	Homo sapiens	69-73
19966058-13	2010	In conclusion, morphine mobilizes intracellular Zn(2+) through the NO/cGMP/PKG signaling pathway and prevents the mPTP opening by inactivating GSK-3beta through Zn(2+).	Zinc	161-163	glycogen synthase kinase 3 beta	Homo sapiens	143-152
19874138-3	2010	In this study we tested the effects of Al3+, Ba2+, Ca2+, Li+, Mn2+, Mo6+, Cd2+, Ni2+, and Zn2+ on purified bovine liver GR.	Zinc	90-94	glutathione-disulfide reductase	Bos taurus	120-122
19874138-9	2010	The effect of Zn2+ on GR activity was consistent with a non-competitive inhibition pattern when the varied substrates were GSSG (Ki(GSSG) 0.320 +/- 0.018 mM) and NADPH (Ki(NADPH) 0.761 +/- 0.04 mM), respectively.	Zinc	14-18	glutathione-disulfide reductase	Bos taurus	22-24
21968700-3	2010	Here, we show that APE1 cleaves RNA in the absence of divalent metal ions and, at 2 mM, Zn(2+), Ni(2+), Cu(2+), or Co(2+) inhibited the endoribonuclease activity of APE1.	Zinc	88-90	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	19-23
21968700-3	2010	Here, we show that APE1 cleaves RNA in the absence of divalent metal ions and, at 2 mM, Zn(2+), Ni(2+), Cu(2+), or Co(2+) inhibited the endoribonuclease activity of APE1.	Zinc	88-90	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	165-169
21108143-9	2010	The effect of Zn2+ on GR activity is consistent with noncompetitive inhibition pattern when the varied substrate is the GSSG (Ki(GSSG) 0.091 +- 0.005 mM) and the NADPH (Ki(NADPH) 0.226 +- 0.01 mM), respectively.	Zinc	14-18	glutathione-disulfide reductase	Bos taurus	22-24
19780904-5	2009	Further studies of the underlying mechanisms showed that Zn(2+)-induced ubiquitination required p38 activation.	Zinc	57-63	mitogen activated protein kinase 14	Rattus norvegicus	96-99
19850345-9	2009	Alveolar epithelial cells treated with thymulin markedly showed a downregulation of the nuclear translocation of RelA (p65), the major transactivating member of the NF-kappaB family, in addition to NF-kappaB(1) (p50) and c-Rel (p75), an effect mildly substantiated with Zn(2+).	Zinc	270-272	RELA proto-oncogene, NF-kB subunit	Homo sapiens	113-117
19850345-9	2009	Alveolar epithelial cells treated with thymulin markedly showed a downregulation of the nuclear translocation of RelA (p65), the major transactivating member of the NF-kappaB family, in addition to NF-kappaB(1) (p50) and c-Rel (p75), an effect mildly substantiated with Zn(2+).	Zinc	270-272	RELA proto-oncogene, NF-kB subunit	Homo sapiens	119-122
19767425-1	2009	GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dependent enzyme that catalyzes the first step of the de novo folate biosynthetic pathway in bacteria and plants, the 7-deazapurine biosynthetic pathway in Bacteria and Archaea, and the biopterin pathway in mammals.	Zinc	46-52	GTP cyclohydrolase 1	Homo sapiens	0-20
19800247-4	2009	Like other metal tolerance proteins (MTPs) in plants, heterologous expression of MtMTP1 can complement the Zn-susceptible zrc1 cot1 yeast double mutant.	Zinc	107-109	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	122-126
19681598-1	2009	TAT peptide functionalized shell-core ZnS-CdSe quantum dots (QDs) have been prepared by three different methods, direct ligand exchange with cysteine-terminated TAT (TAT-QD(lig exch)), and covalent conjugation to QDs coated with silanes (TAT-QD(silica)) and polyacrylate derivatives (TAT-QD(polyacrylate)).	Zinc	38-41	tyrosine aminotransferase	Homo sapiens	0-3
19538181-9	2009	Some Zrc1 mutants lost the ability to transport Zn2+, but others retained the ability to transport Zn2+.	Zinc	48-52	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	5-9
19538181-9	2009	Some Zrc1 mutants lost the ability to transport Zn2+, but others retained the ability to transport Zn2+.	Zinc	99-103	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	5-9
19839356-1	2009	Highly luminescent ZnS : Au, Cu X-ray phosphor fine particles synthesized by hydrothermal method is reported for the first time and its photoluminescence (PL) and X-ray excited luminescence (XEL) properties were studied in detail.	Zinc	19-22	cut like homeobox 1	Homo sapiens	29-33
19557260-0	2009	A Zn-based, pillared paddlewheel MOF containing free carboxylic acids via covalent post-synthesis elaboration.	Zinc	2-4	lysine acetyltransferase 8	Homo sapiens	33-36
19557260-1	2009	A Zn-based, mixed-ligand (pillared paddlewheel), metal-organic framework (MOF) has been covalently and quantitatively decorated with free carboxylic acids to demonstrate the utility of covalent post-synthesis modification in the construction of otherwise inaccessible carboxy-functionalized MOFs.	Zinc	2-4	lysine acetyltransferase 8	Homo sapiens	49-78
19288494-8	2009	Expression of zinc transporter-1 (ZnT-1), previously shown to regulate Zn(2+) influx, increased following prolonged application of zinc or cadmium to the explants and prevented clusterin up-regulation by subsequent exposure to these ions.	Zinc	71-77	solute carrier family 30 (zinc transporter), member 1	Mus musculus	14-32
19288494-8	2009	Expression of zinc transporter-1 (ZnT-1), previously shown to regulate Zn(2+) influx, increased following prolonged application of zinc or cadmium to the explants and prevented clusterin up-regulation by subsequent exposure to these ions.	Zinc	71-77	solute carrier family 30 (zinc transporter), member 1	Mus musculus	34-39
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	13-15	matrix metallopeptidase 2	Homo sapiens	53-58
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	86-88	matrix metallopeptidase 2	Homo sapiens	53-58
19561609-4	2009	In the complex structure, a critical loop from HHIP binds the pseudo active site groove of SHH and directly coordinates its Zn2+ cation.	Zinc	124-128	hedgehog interacting protein	Homo sapiens	47-51
19448295-7	2009	The mixture ratio of Zn and Sn was optimized (40% Zn and 25% Sn) to maintain proper hole-electron recombination at the QD layer and avoid the yellowish-white emission from ZnO/SnO(2).	Zinc	21-23	strawberry notch homolog 1	Homo sapiens	176-179
19207208-0	2009	AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis.	Zinc	51-57	heavy metal atpase 1	Arabidopsis thaliana	0-6
19207208-2	2009	It exhibits amino acid sequence similarity to two other Zn(II) transporters, AtHMA2 and AtHMA4, and contains poly-His motifs that are commonly found in Zn(II)-binding proteins, but lacks some amino acids that are typical for this class of transporters.	Zinc	56-62	heavy metal atpase 4	Arabidopsis thaliana	88-94
19207208-5	2009	The Zn(II)-sensitive phenotype of AtHMA1 knock-out plants was complemented by the expression of AtHMA1 under the control of its own promoter.	Zinc	4-10	heavy metal atpase 1	Arabidopsis thaliana	34-40
19207208-5	2009	The Zn(II)-sensitive phenotype of AtHMA1 knock-out plants was complemented by the expression of AtHMA1 under the control of its own promoter.	Zinc	4-10	heavy metal atpase 1	Arabidopsis thaliana	96-102
19207208-6	2009	The Zn(II)-transporting activity of AtHMA1 was confirmed in a heterologous expression system, Saccharomyces cerevisiae.	Zinc	4-10	heavy metal atpase 1	Arabidopsis thaliana	36-42
19207208-7	2009	The sensitivity of yeast to high concentrations of Zn(II) was altered by the expression of AtHMA1 lacking its N-terminal chloroplast-targeting signal.	Zinc	51-57	heavy metal atpase 1	Arabidopsis thaliana	91-97
19207208-8	2009	Taken together, these results suggest that under conditions of excess Zn(II), AtHMA1 contributes to Zn(II) detoxification by reducing the Zn content of Arabidopsis thaliana plastids.	Zinc	70-76	heavy metal atpase 1	Arabidopsis thaliana	78-84
19207208-8	2009	Taken together, these results suggest that under conditions of excess Zn(II), AtHMA1 contributes to Zn(II) detoxification by reducing the Zn content of Arabidopsis thaliana plastids.	Zinc	100-106	heavy metal atpase 1	Arabidopsis thaliana	78-84
19207208-8	2009	Taken together, these results suggest that under conditions of excess Zn(II), AtHMA1 contributes to Zn(II) detoxification by reducing the Zn content of Arabidopsis thaliana plastids.	Zinc	70-72	heavy metal atpase 1	Arabidopsis thaliana	78-84
19240037-4	2009	Here, we demonstrate that plasmin can cleave the native NR2A amino-terminal domain (NR2A(ATD)), removing the functional high affinity Zn(2+) binding site.	Zinc	134-136	plasminogen	Homo sapiens	26-33
19228020-2	2009	Cu-L1 bound 1.7 equiv of Cu and small amounts of Zn(II) and Fe.	Zinc	49-55	cullin 1	Homo sapiens	0-5
19228020-11	2009	Both Cu-L1 and ZnNi-L1 hydrolyze cephalosporins and carbapenems, but not penicillins, suggesting that the Zn(2) site modulates substrate preference in mbetal L1.	Zinc	106-111	cullin 1	Homo sapiens	5-10
19370272-8	2009	CONCLUSION: The HMW-Zn% is a good index of sperm function rather than the total seminal plasma zinc levels.	Zinc	20-22	cilia and flagella associated protein 97	Homo sapiens	16-19
18951909-10	2009	Finally, these findings suggest that synaptic Zn(2+) may be a factor influencing the effectiveness of therapies that rely on 5-HT(1A) receptor activity.	Zinc	46-48	5-hydroxytryptamine receptor 1A	Rattus norvegicus	125-132
19101503-5	2009	Binding of Ca(2+) or Zn(2+) ions to the doubly phosphorylated CDK2 peptide did not cause any change in absorbance, but increased the affinity of the peptide for Fe(3+) ions.	Zinc	21-23	cyclin dependent kinase 2	Homo sapiens	62-66
19858116-2	2009	An RNAi line with reduced expression of NAM genes has lower grain protein, iron (Fe), and zinc (Zn) concentrations.	Zinc	96-98	NAC domain-containing protein 20	Triticum aestivum	40-43
19210716-2	2009	The expression of IRT3, a ZIP transporter, is higher in the Zn/cadmium (Cd) hyperaccumulator Arabidopsis halleri than is that of its ortholog in Arabidopsis thaliana, which implies a positive association of its expression with Zn accumulation in A. halleri.	Zinc	60-62	iron regulated transporter 3	Arabidopsis thaliana	18-22
19210716-2	2009	The expression of IRT3, a ZIP transporter, is higher in the Zn/cadmium (Cd) hyperaccumulator Arabidopsis halleri than is that of its ortholog in Arabidopsis thaliana, which implies a positive association of its expression with Zn accumulation in A. halleri.	Zinc	227-229	iron regulated transporter 3	Arabidopsis thaliana	18-22
18308622-1	2008	Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of salicylidene-N-cyano-acetohydrazone H2L1 and 2-hydroxy-l-naphthylidene-N-cyanoacetohydrazone H2L2 have been prepared in ethanolic solution and characterized by analytical, spectral, magnetic susceptibility, molar conductivity and TGA measurements.	Zinc	35-41	T-box transcription factor 1	Homo sapiens	285-288
18755683-3	2008	Both PMI1 and PMI2 were inhibited by incubation with EDTA, Zn(2+), Cd(2+), and L-ascorbic acid (AsA).	Zinc	59-61	plastid movement impaired1	Arabidopsis thaliana	5-9
18945899-7	2008	Zn PC exhibited the characteristic features of ischemic PC, including caspase-3 activation, PARP-1 cleavage, and HSP70 induction, all of which are crucial for subsequent neuroprotection against NMDA or zinc toxicity.	Zinc	0-2	caspase 3	Rattus norvegicus	70-79
18945899-9	2008	Interestingly, in both Zn PC in vitro and ischemic PC in vivo, p75(NTR) was necessary for neuroprotection.	Zinc	23-25	nerve growth factor receptor	Rattus norvegicus	63-66
18703071-3	2008	The CNBP family shows a conserved modular organization of seven Zn knuckles and an arginine-glycine-glycine (RGG) box between the first and second Zn knuckles.	Zinc	64-66	CCHC-type zinc finger nucleic acid binding protein L homeolog	Xenopus laevis	4-8
18703071-3	2008	The CNBP family shows a conserved modular organization of seven Zn knuckles and an arginine-glycine-glycine (RGG) box between the first and second Zn knuckles.	Zinc	147-149	CCHC-type zinc finger nucleic acid binding protein L homeolog	Xenopus laevis	4-8
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	heat shock 70 kDa protein 1B	Sus scrofa	171-178
18799003-13	2008	Relative hepatic HSP70.2 (P &lt; 0.002) mRNA abundance was confirmed to be lower in pigs fed 2,000 mg Zn/kg than in pigs fed 150 or 1,000 mg Zn/kg.	Zinc	102-104	heat shock 70 kDa protein 1B	Sus scrofa	17-24
18799003-13	2008	Relative hepatic HSP70.2 (P &lt; 0.002) mRNA abundance was confirmed to be lower in pigs fed 2,000 mg Zn/kg than in pigs fed 150 or 1,000 mg Zn/kg.	Zinc	141-143	heat shock 70 kDa protein 1B	Sus scrofa	17-24
18463798-3	2008	A metal determination study clearly demonstrated that Al(3+) induced the incorporation of Zn(2+) into zrt1Delta cells, probably through the low-affinity Zn(2+) transporter Zrt2p, given that the zrt1Deltazrt2Delta double mutant did not show Al-induced growth enhancement.	Zinc	90-93	low-affinity Zn(2+) transporter ZRT2	Saccharomyces cerevisiae S288C	172-177
18463798-3	2008	A metal determination study clearly demonstrated that Al(3+) induced the incorporation of Zn(2+) into zrt1Delta cells, probably through the low-affinity Zn(2+) transporter Zrt2p, given that the zrt1Deltazrt2Delta double mutant did not show Al-induced growth enhancement.	Zinc	90-92	low-affinity Zn(2+) transporter ZRT2	Saccharomyces cerevisiae S288C	172-177
18473479-5	2008	We show that archaeal Nop10 contains a highly stable Zn2+ binding motif that is replaced in eukaryotes by a smaller meta-stable beta-hairpin, while a highly conserved and conformationally dynamic linker connects these motifs to a nascent alpha-helical structure.	Zinc	53-57	snoRNP complex protein NOP10	Saccharomyces cerevisiae S288C	22-27
18473479-7	2008	Several residues within the archaeal Nop10 Zn2+ binding motif have clear structural and functional roles and are conserved in eukaryotes, yet remain disordered in the free yeast Nop10.	Zinc	43-47	snoRNP complex protein NOP10	Saccharomyces cerevisiae S288C	37-42
18473479-7	2008	Several residues within the archaeal Nop10 Zn2+ binding motif have clear structural and functional roles and are conserved in eukaryotes, yet remain disordered in the free yeast Nop10.	Zinc	43-47	snoRNP complex protein NOP10	Saccharomyces cerevisiae S288C	178-183
18443360-12	2008	We demonstrate that Shaker, like mSlo1, is much more sensitive to Cu2+ than Zn2+ and that sensitivity to these metals is altered by mutating the conserved positions in S1 or S4 or reducing pH.	Zinc	76-80	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	33-38
17955184-9	2008	In particular, the addition of Zn2+ to the bath solution induced a clear decrease of the potassium currents in protoplasts transformed with AKT1 alone, whereas a current potentiation (indicative of KDC1 presence) was observed in protoplasts co-transformed with AKT1 + KDC1::GFP.	Zinc	31-35	K+ transporter 1	Arabidopsis thaliana	140-144
17955184-9	2008	In particular, the addition of Zn2+ to the bath solution induced a clear decrease of the potassium currents in protoplasts transformed with AKT1 alone, whereas a current potentiation (indicative of KDC1 presence) was observed in protoplasts co-transformed with AKT1 + KDC1::GFP.	Zinc	31-35	K+ transporter 1	Arabidopsis thaliana	261-265
17600337-1	2007	Transferrin and mouse anti-human CD71 monoclonal antibody were respectively conjugated covalently to the core/shell CdSe/ZnS quantum dots with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydrocylsulfo-succinimide (Sulfo-NHS).	Zinc	121-124	transferrin receptor	Homo sapiens	33-37
17636324-8	2007	Results are consistent with the view that CAX2 and CAX4 antiporters of tonoplast play a role in tolerance to high, toxic levels of Cd, Zn, and Mn in tobacco.	Zinc	135-137	cation exchanger 2	Arabidopsis thaliana	42-46
17997968-3	2007	We report here the crystal structure, determined at 2.8 A resolution by multiple isomorphous replacement with anomalous scattering, of a truncated Cep3p (Cep3p [47-608]), comprising all but an N-terminal, Zn(2)Cys(6)-cluster, DNA-binding module.	Zinc	205-207	Cep3p	Saccharomyces cerevisiae S288C	147-152
17997968-4	2007	Cep3p has a well-ordered structure throughout essentially all of its polypeptide chain, unlike most yeast transcription factors, including those with Zn(2)Cys(6) clusters, such as Gal4p.	Zinc	150-152	Cep3p	Saccharomyces cerevisiae S288C	0-5
17997968-6	2007	We have, using the structure of Cep3p (47-608) and the known structures of Zn(2)Cys(6)-cluster domains, modeled the interaction of Cep3p with CDEIII.	Zinc	75-80	Cep3p	Saccharomyces cerevisiae S288C	131-136
17895834-2	2007	The aim of this study was to investigate the effects in the pancreas on gene expressions of metallothionein 1 (MT1), divalent metal transporter 1 (DMT1), and zinc transporter 5 (ZnT-5) and concomitant changes in iron (Fe), copper (Cu), and zinc (Zn) in serum and pancreas of Balb/c mice on days 3, 6, and 9 of CVB3 infection.	Zinc	178-180	solute carrier family 30 (zinc transporter), member 5	Mus musculus	158-176
17475084-9	2007	These results suggest that while leptin gene expression may be directly affected by Zn, hNPY and hCRH are likely responding to reduced food intake caused by Zn deficiency.	Zinc	84-86	leptin	Rattus norvegicus	33-39
17565998-4	2007	We now present evidence, by means of direct biochemical assays, that Zn2+ is imported through the Ca2+ uniporter and directly targets major enzymes of energy production (lipoamide dehydrogenase) and antioxidant defense (thioredoxin reductase and glutathione reductase).	Zinc	69-73	dihydrolipoamide dehydrogenase	Homo sapiens	170-193
17565998-4	2007	We now present evidence, by means of direct biochemical assays, that Zn2+ is imported through the Ca2+ uniporter and directly targets major enzymes of energy production (lipoamide dehydrogenase) and antioxidant defense (thioredoxin reductase and glutathione reductase).	Zinc	69-73	glutathione-disulfide reductase	Homo sapiens	246-267
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	121-127
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	207-213
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	227-233
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	255-261
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	207-213
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	227-233
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	255-261
17526568-5	2007	Although the CaV2.2 and CaV3.1 channels had similar IC50 for Zn2+ in Ba2+, the CaV2.2, but not CaV3.1 channels, had approximately 10-fold higher IC50 to Zn2+ in Ca2+.	Zinc	61-65	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	13-19
17526568-5	2007	Although the CaV2.2 and CaV3.1 channels had similar IC50 for Zn2+ in Ba2+, the CaV2.2, but not CaV3.1 channels, had approximately 10-fold higher IC50 to Zn2+ in Ca2+.	Zinc	61-65	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	24-30
17526568-5	2007	Although the CaV2.2 and CaV3.1 channels had similar IC50 for Zn2+ in Ba2+, the CaV2.2, but not CaV3.1 channels, had approximately 10-fold higher IC50 to Zn2+ in Ca2+.	Zinc	153-157	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	79-85
17526568-6	2007	The reduced sensitivity of CaV2.2 channels to Zn2+ in Ca2+ was partially reversed by disrupting a putative EF-hand motif located external to the selectivity filter EEEE locus.	Zinc	46-50	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	27-33
17239974-2	2007	In addition to Ca2+ S100A2 binds Zn2+ with a high affinity.	Zinc	33-37	S100 calcium binding protein A2	Homo sapiens	20-26
17239974-3	2007	Studies have been carried out to investigate whether Zn2+ acts as a regulatory ion for S100A2, as in the case of Ca2+.	Zinc	53-57	S100 calcium binding protein A2	Homo sapiens	87-93
17239974-4	2007	Using the method of competition with the Zn2+ chelator 4-(2-pyridylazo)-resorcinol, an apparent Kd of 25 nM has been determined for Zn2+ binding to S100A2.	Zinc	41-45	S100 calcium binding protein A2	Homo sapiens	148-154
17239974-4	2007	Using the method of competition with the Zn2+ chelator 4-(2-pyridylazo)-resorcinol, an apparent Kd of 25 nM has been determined for Zn2+ binding to S100A2.	Zinc	132-136	S100 calcium binding protein A2	Homo sapiens	148-154
17239974-5	2007	The affinity lies close to the range of intracellular free Zn2+ concentrations, suggesting that S100A2 is able to bind Zn2+ in the nucleus.	Zinc	59-63	S100 calcium binding protein A2	Homo sapiens	96-102
17239974-5	2007	The affinity lies close to the range of intracellular free Zn2+ concentrations, suggesting that S100A2 is able to bind Zn2+ in the nucleus.	Zinc	119-123	S100 calcium binding protein A2	Homo sapiens	96-102
17239974-9	2007	Remarkably, only binding of Zn2+ to site 2 substantially weakens the affinity of S100A2 for Ca2+.	Zinc	28-32	S100 calcium binding protein A2	Homo sapiens	81-87
17239974-11	2007	These findings imply that S100A2 is regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals.	Zinc	54-58	S100 calcium binding protein A2	Homo sapiens	26-32
17239974-11	2007	These findings imply that S100A2 is regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals.	Zinc	86-90	S100 calcium binding protein A2	Homo sapiens	26-32
17239974-11	2007	These findings imply that S100A2 is regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals.	Zinc	86-90	S100 calcium binding protein A2	Homo sapiens	108-114
17008051-0	2007	Zn2+-induced NF-kappaB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation.	Zinc	0-4	RELA proto-oncogene, NF-kB subunit	Homo sapiens	81-84
17008051-0	2007	Zn2+-induced NF-kappaB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation.	Zinc	0-4	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-89
17008051-6	2007	We also observed that 50 microM Zn2+ exposure caused p65/RelA phosphorylation on Ser 276, Ser 529, and Ser 536 in both cytoplasmic and nuclear cell fractions.	Zinc	32-36	RELA proto-oncogene, NF-kB subunit	Homo sapiens	53-56
17008051-6	2007	We also observed that 50 microM Zn2+ exposure caused p65/RelA phosphorylation on Ser 276, Ser 529, and Ser 536 in both cytoplasmic and nuclear cell fractions.	Zinc	32-36	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-61
17085522-13	2007	Zn supplementation normalized ZIP1 and ZIP14, but it did not affect mRNA levels of cytokines or their receptors.	Zinc	0-2	solute carrier family 39 (zinc transporter), member 14	Mus musculus	39-44
16959833-3	2007	Although Zn(2+) stimulated inositol phosphate turnover, cAMP production, arrestin mobilization, as well as cAMP response element-dependent and serum response element-dependent transcriptional activity in GPR39-expressing cells as opposed to mock-transfected cells, no reproducible effect was obtained with obestatin in the GPR39-expressing cells.	Zinc	9-15	G protein-coupled receptor 39	Mus musculus	204-209
16959833-3	2007	Although Zn(2+) stimulated inositol phosphate turnover, cAMP production, arrestin mobilization, as well as cAMP response element-dependent and serum response element-dependent transcriptional activity in GPR39-expressing cells as opposed to mock-transfected cells, no reproducible effect was obtained with obestatin in the GPR39-expressing cells.	Zinc	9-15	G protein-coupled receptor 39	Mus musculus	323-328
16959833-8	2007	In contrast, the potency and efficacy of Zn(2+) in respect of activating signaling indicates that this metal ion could be a physiologically relevant agonist or modulator of GPR39.	Zinc	41-43	G protein-coupled receptor 39	Mus musculus	173-178
17082234-3	2007	Using tsA-201 cells, we demonstrate that CaV3.2 current (IC50, 0.8 microm) is significantly more sensitive to Zn2+ than are CaV3.1 and CaV3.3 currents (IC50, 80 microm and approximately 160 microm, respectively).	Zinc	110-114	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	41-47
17082234-7	2007	Consequently, application of Zn2+ results in a significant increase in CaV3.3 current in action potential clamp experiments, while CaV3.1 and CaV3.2 currents are significantly reduced.	Zinc	29-33	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	131-137
17082234-7	2007	Consequently, application of Zn2+ results in a significant increase in CaV3.3 current in action potential clamp experiments, while CaV3.1 and CaV3.2 currents are significantly reduced.	Zinc	29-33	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	142-148
17082234-8	2007	In neuroblastoma NG 108-15 cells, the duration of CaV3.3-mediated action potentials is increased upon Zn2+ application, indicating further that Zn2+ behaves as a CaV3.3 channel opener.	Zinc	102-106	calcium channel, voltage-dependent, alpha 1I subunit	Mus musculus	50-56
17082234-8	2007	In neuroblastoma NG 108-15 cells, the duration of CaV3.3-mediated action potentials is increased upon Zn2+ application, indicating further that Zn2+ behaves as a CaV3.3 channel opener.	Zinc	144-148	calcium channel, voltage-dependent, alpha 1I subunit	Mus musculus	50-56
16964525-6	2006	We present here evidence that, following experimental depletion of Zn, both NF-kappaB and AP-1 signallings are altered in primary T cells isolated from young and elderly healthy individuals under CD3/CD28 costimulation.	Zinc	67-69	CD28 molecule	Homo sapiens	200-204
16964525-7	2006	A supplementation of Zn restored both NF-kappaB and AP-1 activation in CD3/CD28 costimulated T cells from young, but not from elderly, healthy individuals, indicating that the Zn deficiency is only one component of a more complex mechanism involved in immunosenescence.	Zinc	21-23	CD28 molecule	Homo sapiens	75-79
16964525-7	2006	A supplementation of Zn restored both NF-kappaB and AP-1 activation in CD3/CD28 costimulated T cells from young, but not from elderly, healthy individuals, indicating that the Zn deficiency is only one component of a more complex mechanism involved in immunosenescence.	Zinc	176-178	CD28 molecule	Homo sapiens	75-79
16950869-5	2006	Zip14 was found to localize to the plasma membrane, and its overexpression increased the uptake of both (65)Zn and (59)Fe.	Zinc	108-110	solute carrier family 39 member 14	Homo sapiens	0-5
16844841-5	2006	The encoded proteins include HMA4, known to contribute to root-shoot transport of Zn in A. thaliana.	Zinc	82-84	heavy metal atpase 4	Arabidopsis thaliana	29-33
16844841-6	2006	Expression of either AtHMA4 or AhHMA4 confers cellular Zn and Cd tolerance to yeast (Saccharomyces cerevisiae).	Zinc	55-57	heavy metal atpase 4	Arabidopsis thaliana	21-27
16844841-7	2006	Among further newly implicated proteins are IRT3 and ZIP10, which have been proposed to contribute to cytoplasmic Zn influx, and FRD3 required for iron partitioning in A. thaliana.	Zinc	114-116	iron regulated transporter 3	Arabidopsis thaliana	44-48
16584753-10	2006	These results suggest that the accumulation of Zn2+ following an ischemic insult can cause retinal degeneration and induce abnormal COX-2 expression.	Zinc	47-51	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	132-137
16834351-5	2006	The activation energy for solid-solution formation was determined as approximately 152 kJ/mol, which evidently indicates that the diffusion of Zn2+ ions in the CdSe-ZnSe system is the governing mechanism for the Cd1-xZnxSe solid-solution formation.	Zinc	143-147	CD1c molecule	Homo sapiens	212-215
16819821-5	2006	However, Zn2+ concentrations in the range of those found in boar seminal plasma induce the unfolding and self-association of PSP-I, apparently as a consequence of the exposure of hydrophobic core residues, whereas they have no effect on PSP-II.	Zinc	9-13	major seminal plasma glycoprotein PSP-I	Sus scrofa	125-130
16819821-7	2006	Thus, the modulation of the structural organization and heparin-binding ability of PSP-I by Zn2+ might be a physiological phenomenon in seminal plasma.	Zinc	92-96	major seminal plasma glycoprotein PSP-I	Sus scrofa	83-88
16772438-10	2006	In both experiments, the villous height of the small-intestinal mucosa and both the mRNA and protein levels for IGF-I and IGF-IR in the small intestine were markedly enhanced (P &lt; 0.05) by feeding elevated levels of Zn.	Zinc	219-221	insulin like growth factor 1	Sus scrofa	112-117
16772438-12	2006	Collectively, these results suggest that dietary Zn supplementation exerts its beneficial effects on the intestinal growth of weanling piglets through increasing IGF-I and IGF-IR expression in the small-intestinal mucosa.	Zinc	49-51	insulin like growth factor 1	Sus scrofa	162-167
16845233-9	2006	Altogether, obtained data suggest that Cu inhibits Kv1.3 channels by a different mechanism than Zn and that Cu and Zn act on different binding sites.	Zinc	115-117	potassium voltage-gated channel subfamily A member 3	Homo sapiens	51-56
16771564-1	2006	We present a study of the light extraction from CdSe/ZnS core/shell colloidal quantum dot thin films deposited on quantum well InGaN/GaN photonic crystal structures.	Zinc	53-56	gigaxonin	Homo sapiens	129-132
16519517-1	2006	Bovine lens leucyl aminopeptidase (blLAP), a homohexameric metallopeptidase preferring bulky and hydrophobic amino acids at the N-terminus of (di)peptides, contains two Zn(2+) ions per subunit that are essential for catalytic activity.	Zinc	169-171	leucine aminopeptidase 3	Bos taurus	12-33
16439662-3	2006	Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly.	Zinc	0-4	SH3 and multiple ankyrin repeat domains 3	Rattus norvegicus	73-79
16332354-0	2006	Identification of a Zn2+-binding site on the dopamine D2 receptor.	Zinc	20-24	dopamine receptor D2	Homo sapiens	45-65
16332354-2	2006	To identify the Zn(2+)-binding site responsible for allosteric modulation of the D(2) dopamine receptor, we first demonstrated that the binding site is likely located in extracellular loops or in transmembrane regions that are accessible from the extracellular milieu.	Zinc	16-22	dopamine receptor D2	Homo sapiens	81-103
16332354-7	2006	We conclude that binding of Zn(2+) to H394 and H399 on the dopamine D(2) receptor contributes to allosteric regulation of antagonist binding.	Zinc	28-30	dopamine receptor D2	Homo sapiens	59-81
16153601-0	2005	Cloning and characterization of a mitochondrial glyoxalase II from Brassica juncea that is upregulated by NaCl, Zn, and ABA.	Zinc	112-114	hydroxyacylglutathione hydrolase	Homo sapiens	48-61
16055450-9	2005	These analyses further suggested that metal sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration.	Zinc	167-173	metal regulatory transcription factor 1	Homo sapiens	55-60
16055687-11	2005	While the ionome of cax1 and cax3 lines were modestly perturbed, the cax1/cax3 lines displayed increased PO4(3-), Mn2+, and Zn2+ and decreased Ca2+ and Mg2+ in shoot tissue.	Zinc	124-128	cation exchanger 1	Arabidopsis thaliana	69-73
15949864-3	2005	By correlating the occurrence of NrdR-boxes with phylogenetic distribution of ortholog families, we identified a transcriptional regulator containing Zn-ribbon and ATP-cone motifs (COG1327) for the predicted ribonucleotide reductase regulon.	Zinc	150-152	dehydrogenase/reductase 4	Homo sapiens	33-37
15863613-11	2005	Transfection of mZip14 cDNA into human embryonic kidney cells increased zinc uptake as measured by both a fluorescent probe for free Zn(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip14 functions as a zinc importer.	Zinc	133-135	solute carrier family 39 (zinc transporter), member 14	Mus musculus	16-22
15863613-11	2005	Transfection of mZip14 cDNA into human embryonic kidney cells increased zinc uptake as measured by both a fluorescent probe for free Zn(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip14 functions as a zinc importer.	Zinc	133-135	solute carrier family 39 member 14	Homo sapiens	17-22
15863613-11	2005	Transfection of mZip14 cDNA into human embryonic kidney cells increased zinc uptake as measured by both a fluorescent probe for free Zn(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip14 functions as a zinc importer.	Zinc	148-150	solute carrier family 39 (zinc transporter), member 14	Mus musculus	16-22
15863613-11	2005	Transfection of mZip14 cDNA into human embryonic kidney cells increased zinc uptake as measured by both a fluorescent probe for free Zn(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip14 functions as a zinc importer.	Zinc	148-150	solute carrier family 39 member 14	Homo sapiens	17-22
15843525-4	2005	Point mutations that disrupt the Zn(2+)-chelating ability of its amino-terminal RING finger domain abolished TRAC-1"s ligase activity and the dominant inhibitory effect of C-terminal truncated TRAC-1 on TCR stimulation.	Zinc	33-39	ring finger protein 125	Homo sapiens	109-115
15843525-4	2005	Point mutations that disrupt the Zn(2+)-chelating ability of its amino-terminal RING finger domain abolished TRAC-1"s ligase activity and the dominant inhibitory effect of C-terminal truncated TRAC-1 on TCR stimulation.	Zinc	33-39	ring finger protein 125	Homo sapiens	193-199
15851831-3	2005	The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg.	Zinc	167-169	leptin	Rattus norvegicus	11-17
15841324-2	2005	The matrix metalloproteinases (MMPs) are a family of Zn(++) and Ca(++) dependent endopeptidases, which are key mediators of ECM remodelling.	Zinc	53-59	matrix metallopeptidase 2	Homo sapiens	31-35
15721369-4	2005	Using APOBEC3G deletion and point mutants, we mapped the encapsidation determinant to the Zn(2+) coordination residues of the N-terminal catalytic domain (CD1).	Zinc	90-92	CD1c molecule	Homo sapiens	155-158
15721369-7	2005	The Zn(2+) coordination residues of the C-terminal catalytic domain (CD2) were not required for encapsidation but were essential for cytidine deaminase activity and the antiviral effect.	Zinc	4-10	cytidine deaminase	Homo sapiens	133-151
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Zinc	4-6	copper chaperone for superoxide dismutase	Homo sapiens	19-22
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Zinc	4-6	copper chaperone for superoxide dismutase	Homo sapiens	129-132
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Zinc	89-91	copper chaperone for superoxide dismutase	Homo sapiens	19-22
15736924-8	2005	The Zn-EXAFS of WT CCS showed a 3-4 histidine ligand environment that is consistent with Zn binding in the SOD-like domain II of CCS.	Zinc	89-91	copper chaperone for superoxide dismutase	Homo sapiens	129-132
15664623-7	2005	For example, in addition to the well-characterized soluble Cu/Zn enzyme (Sod) and mitochondrial manganese-containing form (Sod2), Drosophila melanogaster is found to contain a putative copper chaperone (CCS), an extracellular Cu/Zn enzyme (Sod3), and an extracellular protein distantly related to the Cu/Zn forms (Sodq).	Zinc	62-64	Superoxide dismutase 1	Drosophila melanogaster	73-76
15564445-7	2004	Zn(2+) significantly stimulated NF-kappa B and AP-1 activation in NOD mice, in contrast, in C57BL/6 mice, Zn(2+) significantly reduced their activation by MLD-STZ.	Zinc	0-2	jun proto-oncogene	Mus musculus	47-51
15653794-7	2004	Mesophyll cells of the mtp1-1 mutant plants grown in the presence of 500 microM Zn were degraded, suggesting that Zn at high concentrations causes serious damage to leaves and that AtMTP1 plays a crucial role in preventing this damage in plants.	Zinc	80-82	Cation efflux family protein	Arabidopsis thaliana	23-29
15653794-7	2004	Mesophyll cells of the mtp1-1 mutant plants grown in the presence of 500 microM Zn were degraded, suggesting that Zn at high concentrations causes serious damage to leaves and that AtMTP1 plays a crucial role in preventing this damage in plants.	Zinc	114-116	Cation efflux family protein	Arabidopsis thaliana	23-29
15504035-11	2004	TTP"s ARE binding activity was increased by 10 microM Zn(2+).	Zinc	54-60	ZFP36 ring finger protein	Homo sapiens	0-3
15476377-5	2004	The cell-permeable ZP3 probe is capable of identifying natural pools of labile Zn(2+) within the mossy fiber synapses of live hippocampal slices using TPM, establishing the application of this technique for monitoring endogenous Zn(2+) stores.	Zinc	79-81	zona pellucida glycoprotein 3	Homo sapiens	19-22
15476377-5	2004	The cell-permeable ZP3 probe is capable of identifying natural pools of labile Zn(2+) within the mossy fiber synapses of live hippocampal slices using TPM, establishing the application of this technique for monitoring endogenous Zn(2+) stores.	Zinc	79-85	zona pellucida glycoprotein 3	Homo sapiens	19-22
15516700-4	2004	In the present study, it has been observed that both Cr and Zn, upon prolonged exposure, could stimulate tyrosine phosphorylation of insulin receptor (IR) even in the absence of insulin.	Zinc	60-62	insulin receptor	Homo sapiens	133-149
15516700-4	2004	In the present study, it has been observed that both Cr and Zn, upon prolonged exposure, could stimulate tyrosine phosphorylation of insulin receptor (IR) even in the absence of insulin.	Zinc	60-62	insulin receptor	Homo sapiens	151-153
15223154-0	2004	The role of Zn in the interplay among Langmuir-Blodgett multilayer and myelin basic protein: a quantitative analysis of XANES spectra.	Zinc	12-14	myelin basic protein	Homo sapiens	71-91
15096503-6	2004	Furthermore, we show that Zn(2+) inhibits Raf-1 binding to ZnT-1.	Zinc	26-28	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	42-47
15169884-4	2004	The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner.	Zinc	115-121	nuclear receptor binding SET domain protein 1	Homo sapiens	105-109
15169884-4	2004	The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner.	Zinc	115-121	nuclear receptor binding SET domain protein 1	Homo sapiens	221-225
15094391-2	2004	Our previous studies suggested that Zn-induced osteoblast differentiation and Ca2+-, PO4(3-)-stimulated osteopontin (OPN) expression might result from their up-regulation effect on SVCT2 expression and AA uptake.	Zinc	36-38	solute carrier family 23 member 2	Homo sapiens	181-186
14707133-8	2004	RNA interference silencing of ceruloplasmin expression reduced the extent of Zn(II)-supported degradation.	Zinc	77-83	ceruloplasmin	Rattus norvegicus	30-43
14707133-10	2004	However, in the presence of Cu(II)-loaded ceruloplasmin, heparan sulfate in Zn(II)-loaded glypican-1 underwent extensive, ascorbate-induced degradation.	Zinc	76-82	ceruloplasmin	Rattus norvegicus	42-55
14707133-11	2004	We propose that the Cu(II)-to-Cu(I)-reduction that is required for S-nitrosylation of glypican-1 can take place on ceruloplasmin and thereby ensure extensive glypican-1 processing in the presence of free Zn(II) ions.	Zinc	204-206	ceruloplasmin	Rattus norvegicus	115-128
14641108-7	2004	These structural effects of Zn2 binding on TFIIB may have a critical role in interactions with its binding partners, such as the Rpb1 subunit of RNA polymerase II.	Zinc	28-31	RNA polymerase II subunit A	Homo sapiens	129-133
15036267-4	2004	We propose second generation selective MMPs, directed toward gelatinase A (MMP-2), based on a non-hydroxamate Zn-ligand grafted on the galardin (ilomastat) skeleton.	Zinc	110-112	matrix metallopeptidase 2	Homo sapiens	39-43
15036267-4	2004	We propose second generation selective MMPs, directed toward gelatinase A (MMP-2), based on a non-hydroxamate Zn-ligand grafted on the galardin (ilomastat) skeleton.	Zinc	110-112	matrix metallopeptidase 2	Homo sapiens	75-80
15832497-2	2004	Matrix metalloproteinases-2 and -9 (MMP-2 and -9, respectively) are cell-surface Zn-dependent endoproteases associated with diverse processes throughout tumor formation and progression.	Zinc	81-83	matrix metallopeptidase 2	Homo sapiens	0-34
15832497-2	2004	Matrix metalloproteinases-2 and -9 (MMP-2 and -9, respectively) are cell-surface Zn-dependent endoproteases associated with diverse processes throughout tumor formation and progression.	Zinc	81-83	matrix metallopeptidase 2	Homo sapiens	36-48
12944405-10	2003	Elevated Zn2+ concentrations are required for FXI but not PK binding, but the presence of physiologic concentrations of PK and HK also prevented FXI binding.	Zinc	9-13	coagulation factor XI	Homo sapiens	46-49
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	141-143	complement C4B (Chido blood group)	Homo sapiens	39-42
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	141-143	complement C4B (Chido blood group)	Homo sapiens	67-70
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	141-143	endogenous retrovirus group K member 3	Homo sapiens	71-74
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	141-143	endogenous retrovirus group K member 3	Homo sapiens	96-99
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	174-176	complement C4B (Chido blood group)	Homo sapiens	39-42
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	174-176	complement C4B (Chido blood group)	Homo sapiens	67-70
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	174-176	endogenous retrovirus group K member 3	Homo sapiens	71-74
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	174-176	endogenous retrovirus group K member 3	Homo sapiens	96-99
14507713-8	2003	In addition, the attraction can be enhanced when the mica has been pretreated by transition metal cations (Ni(2+), Zn(2+)).	Zinc	115-117	MHC class I polypeptide-related sequence A	Homo sapiens	53-57
12924942-2	2003	The Zn(2+)-binding cysteine/histidine-rich 1 (CH1) domain of p300/CBP binds many of these transcription factors, including hypoxia-inducible factor (HIF).	Zinc	4-10	E1A binding protein p300	Homo sapiens	61-65
12835493-2	2003	In the presence of Zn2+, Cu2+, Cd2+, and Au+ in the incubation mixture at the concentrations of 1 x 10(-5) - 1x 10(-3) M, the amidolytic plasmin activity was strongly inhibited, whereas Ca2+ and Mg2+ at the same concentrations were not effective.	Zinc	19-23	plasminogen	Homo sapiens	137-144
12835493-3	2003	The analysis of the kinetic study has shown that Zn2+ or Cu2+ acts as mixed-type inhibitors of plasmin activity.	Zinc	49-53	plasminogen	Homo sapiens	95-102
12835493-4	2003	The inhibition of amidolytic plasmin activity by Zn2+ and Cu2+ was reduced in the presence of EDTA, histidine, or albumin.	Zinc	49-53	plasminogen	Homo sapiens	29-36
12835493-5	2003	Incubation of plasmin with Zn2+ or Cu2+ (at the concentration of 5 x 10(-4) M) resulted in complete loss of its proteolytic action on fibrinogen, whereas Cd2+ and Au+ under the same conditions only partially inhibited this process.	Zinc	27-31	plasminogen	Homo sapiens	14-21
12848823-3	2003	We cloned and characterised a member of this family, AtHMA4, from Arabidopsis thaliana that clusters with the Zn/Co/Cd/Pb subclass of HMAs on phylogenetic analysis.	Zinc	110-112	heavy metal atpase 4	Arabidopsis thaliana	53-59
12848823-6	2003	AtHMA4 was able to restore growth at high [Zn] in the zntA mutant but not at high [Cu] in the copA mutant, suggesting a role in zinc transport.	Zinc	43-45	heavy metal atpase 4	Arabidopsis thaliana	0-6
12848823-9	2003	AtHMA4 was upregulated in roots exposed to elevated levels of Zn and Mn but downregulated by Cd.	Zinc	62-64	heavy metal atpase 4	Arabidopsis thaliana	0-6
16256525-1	2003	A Zn/Al hydrotalcite-like compound (HTlc) was prepared by co-precipitation (at constant pH) method and was characterized by XRD, TG/DTA, FTIR, and BET surface area.	Zinc	2-4	delta/notch like EGF repeat containing	Homo sapiens	147-150
12646273-4	2003	Purified recombinant TTP bound to the AU-rich element of tumor necrosis factor-alpha (TNFalpha) mRNA and this binding was dependent on Zn(2+).	Zinc	135-137	ZFP36 ring finger protein	Homo sapiens	21-24
12606709-3	2003	This alteration is hypothesized to cause neurodegeneration by permitting a lethal influx of Ca(2+) and/or Zn(2+) through newly formed GluR2-lacking AMPA receptors.	Zinc	106-108	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	134-139
12684163-6	2003	RESULTS AND CONCLUSIONS: Immunohistologic localization of endothelial cells was best accomplished using anti-CD31 in Zn-fixed, paraffin-embedded tissues.	Zinc	117-119	platelet/endothelial cell adhesion molecule 1	Mus musculus	109-113
12684163-10	2003	We conclude that anti-CD31 immunostaining in Zn-fixed, paraffin-embedded murine tissue offered superior morphology and permitted optimal identification of proliferating endothelial cells during infarct repair.	Zinc	45-47	platelet/endothelial cell adhesion molecule 1	Mus musculus	22-26
12686747-8	2003	In monkey brain mitochondria, MAO-A was highly sensitive to Zn(2+) and MAO-B was less sensitive.	Zinc	60-62	monoamine oxidase A	Rattus norvegicus	30-35
12593667-1	2003	Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions.	Zinc	185-187	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	28-33
12526718-1	2003	A photoinduced hydrogen production system that couples sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using visible light-induced photosensitization of artificial Zn chlorophyll-a (Zn Chl-a) has been developed.	Zinc	245-247	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	117-120
14977435-8	2003	Serum leptin showed a tendency to increase during the Zn-depletion period and decreased back to the level of the Zn-repletion period.	Zinc	54-56	leptin	Rattus norvegicus	6-12
14977435-8	2003	Serum leptin showed a tendency to increase during the Zn-depletion period and decreased back to the level of the Zn-repletion period.	Zinc	113-115	leptin	Rattus norvegicus	6-12
14977435-9	2003	Leptin mRNA levels in inguinal adipocytes also increased during the Zn-depletion (P &lt;.05) and Zn-deficient periods, which is consistent with the change in serum leptin.	Zinc	68-70	leptin	Rattus norvegicus	0-6
14977435-9	2003	Leptin mRNA levels in inguinal adipocytes also increased during the Zn-depletion (P &lt;.05) and Zn-deficient periods, which is consistent with the change in serum leptin.	Zinc	97-99	leptin	Rattus norvegicus	0-6
12643543-5	2003	Zn2+-titration of recoverin, traced by bis-ANS fluorescence, reveals binding of a single Zn2+ ion per protein molecule.	Zinc	0-4	recoverin	Homo sapiens	18-27
12643543-5	2003	Zn2+-titration of recoverin, traced by bis-ANS fluorescence, reveals binding of a single Zn2+ ion per protein molecule.	Zinc	89-93	recoverin	Homo sapiens	18-27
12643543-9	2003	Apparent zinc equilibrium binding constants evaluated from spectrofluorimetric Zn2+-titrations of the protein are 1.4 x 10(5) M(-1) (dissociation constant 7.1 microM) for Ca2+-loaded wild-type recoverin and 3.3 x 10(4) M(-1) (dissociation constant 30 microM) for the E85Q/E121Q mutant (analogue of apo-recoverin).	Zinc	79-83	recoverin	Homo sapiens	193-202
12643543-9	2003	Apparent zinc equilibrium binding constants evaluated from spectrofluorimetric Zn2+-titrations of the protein are 1.4 x 10(5) M(-1) (dissociation constant 7.1 microM) for Ca2+-loaded wild-type recoverin and 3.3 x 10(4) M(-1) (dissociation constant 30 microM) for the E85Q/E121Q mutant (analogue of apo-recoverin).	Zinc	79-83	recoverin	Homo sapiens	302-311
12643543-10	2003	Study of the binding of wild-type recoverin to ROS membranes showed a zinc-dependent increase of its affinity for the membranes, without regard to calcium content, suggesting further solvation of a protein myristoyl group upon Zn2+ binding.	Zinc	227-231	recoverin	Homo sapiens	34-43
12518234-3	2003	The results showed that the deletion of PHO85 or PHO80 gene both increased sensibility of Sacchromyces cerevisiae to ions K(+), Mg(2+), Zn(2+), Ca(2+) and Mn(2+), while the deletion of pap1(pcl-7) gene did not lead to such phenotype.	Zinc	136-138	Pho80p	Saccharomyces cerevisiae S288C	49-54
12518234-4	2003	The difference between the patterns of relative growth curve of the mutants and wild type strain in the above ions also implied that PHO80 was the unique PCLs in complex with PHO85 CDK, that were contributed to K(+) and Mg(2+) ion homeostasis control and there were some other PCLs besides PHO80 that were involved in Zn(2+), Ca(2+) and Mn(2+) tolerance regulation as cyclin of PHO85 CDK.	Zinc	318-320	Pho80p	Saccharomyces cerevisiae S288C	133-138
12209932-3	2002	The zinc release rate of ZnTCP/HAP1.64 with a 0.21 Zn wt % nearly coincided with that of ZnTCP/HAP1.60 with a 0.316 Zn wt %, which was found be the most effective for promoting bone formation in rabbit femora.	Zinc	25-27	huntingtin-associated protein 1	Oryctolagus cuniculus	31-35
12209932-3	2002	The zinc release rate of ZnTCP/HAP1.64 with a 0.21 Zn wt % nearly coincided with that of ZnTCP/HAP1.60 with a 0.316 Zn wt %, which was found be the most effective for promoting bone formation in rabbit femora.	Zinc	25-27	huntingtin-associated protein 1	Oryctolagus cuniculus	95-99
12209932-3	2002	The zinc release rate of ZnTCP/HAP1.64 with a 0.21 Zn wt % nearly coincided with that of ZnTCP/HAP1.60 with a 0.316 Zn wt %, which was found be the most effective for promoting bone formation in rabbit femora.	Zinc	51-53	huntingtin-associated protein 1	Oryctolagus cuniculus	31-35
12496117-5	2002	The myelin basic protein induces a distortion on the Zn local environment due to a steric constraint but does not substitute the phosphate headgroups.	Zinc	53-55	myelin basic protein	Homo sapiens	4-24
12186633-4	2002	Additionally, rPrP binding to GAGs is enhanced in the presence of Cu2+ and Zn2+, but not Ca2+ and Mn2+.	Zinc	75-79	prion protein	Rattus norvegicus	14-18
12161436-8	2002	Both Zrc1-dependent and independent activities showed a high specificity for Zn(2+) over other physiologically relevant substrates such as Ca2+, Fe2+, and Mn2+.	Zinc	77-79	Zn(2+) transporter ZRC1	Saccharomyces cerevisiae S288C	5-9
12237228-5	2002	Protoporphyrin IX compounds where the native Fe was substituted with Zn, Mn, Co, or Sn lead to assembly of nNOS, but no detectable NO was synthesized in the presence of NADPH and L-arginine.	Zinc	69-71	nitric oxide synthase 1	Homo sapiens	107-111
12186550-7	2002	Using mass spectrometry, NMR, and fluorescence techniques, we show that native state binding is localized to H31 and W60 and is highly specific for Cu(2+) over Zn(2+) and Ni(2+).	Zinc	160-162	H3 clustered histone 6	Homo sapiens	109-112
12122058-6	2002	Their location in a modeled three-dimensional structure suggests that ifenprodil binds in the cleft of the LIVBP-like domain of NR2B by a mechanism (Venus-flytrap) resembling that of the binding of Zn on the LIVBP-like domain of NR2A.	Zinc	198-200	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	128-132
12109104-1	2002	Four Zn(II) ions arranged within a pyridine-modified large phenolate-containing macrocyle Lpy2- encapsulate two chloranilate ions in a double bis-didentate bridging fashion; the ligands are strongly pi-pi stacked with each other with a short distance of 3.27 A and are electrochemically reduced at the same potential of -1.00 V to produce a reasonably stable biradical species with T1/2 = 60 min at 25 degrees C.	Zinc	5-11	interleukin 1 receptor like 1	Homo sapiens	382-391
12049729-3	2002	CDF-1 reduces intracellular Zn(2+) levels, indicating an inhibitory effect of Zn(2+) on the Ras pathway.	Zinc	28-34	Cation diffusion facilitator family protein 1	Caenorhabditis elegans	0-5
12049729-3	2002	CDF-1 reduces intracellular Zn(2+) levels, indicating an inhibitory effect of Zn(2+) on the Ras pathway.	Zinc	78-84	Cation diffusion facilitator family protein 1	Caenorhabditis elegans	0-5
11757616-4	2001	At high Zn(II) concentrations (&gt;1000 microM), the precipitation of beta2-Zn-(OH)2 (&lt; pH 12) and calcium zincate (Zn2Ca(OH)6 x 2H2O, &gt; pH 12) was observed.	Zinc	8-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	70-75
11533229-6	2001	Ecm22p and Upc2p are members of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors and share no homology to the analogous proteins, SREBPs, that are responsible for transcriptional regulation by sterols in humans.	Zinc	52-57	Ecm22p	Saccharomyces cerevisiae S288C	0-6
11347904-7	2001	All the functional domains (Zn-binding RING finger motif, coiled-coil region, WD-40 repeats, cytoplasmic/nuclear localization sequences and protein-protein interaction domains) that are known in the COP1 proteins from dicots are conserved in COP1 from rice as well.	Zinc	28-30	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	199-203
11962512-9	2001	These results show that the interaction of the ABC ligand with zinc(II), oligonucleotides, DNA and topoisomerase II is different to streptonigrin and hence the design of biologically active ABC ring analogues of streptongrin that operate via different mechanisms should be possible.	Zinc	63-71	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	47-50
11962512-9	2001	These results show that the interaction of the ABC ligand with zinc(II), oligonucleotides, DNA and topoisomerase II is different to streptonigrin and hence the design of biologically active ABC ring analogues of streptongrin that operate via different mechanisms should be possible.	Zinc	63-71	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	190-193
11307829-1	2001	Biotin-FXI optimally bound to HUVEC in the presence of 40 nM high molecular weight kininogen (HK) and &gt; or =7 microM Zn2+.	Zinc	120-124	coagulation factor XI	Homo sapiens	7-10
11179954-8	2001	Altogether, the results presented here suggest that Zn2+ at the active center of the thimet oligopeptidase is the target for the ATP binding, leading to the inhibition of the enzyme activity, and inducing autophosphorylation.	Zinc	52-56	thimet oligopeptidase 1	Homo sapiens	85-106
11162381-2	2001	Zn2+ can bind to this site to replace Mg2+, which inhibits Csk kinase activity.	Zinc	0-4	C-terminal Src kinase	Homo sapiens	59-62
11162381-3	2001	The binding is reversible and removal of Zn2+ results in an active Csk apoenzyme.	Zinc	41-45	C-terminal Src kinase	Homo sapiens	67-70
11352018-4	2001	nc-ZnS exhibits higher photocatalytic activitythan nc-CdS due to the more negative potential of the electrons on nc-ZnS than that on nc-CdS.	Zinc	3-6	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
11352018-4	2001	nc-ZnS exhibits higher photocatalytic activitythan nc-CdS due to the more negative potential of the electrons on nc-ZnS than that on nc-CdS.	Zinc	3-6	CDP-diacylglycerol synthase 1	Homo sapiens	136-139
11172467-1	2001	We examined the effects of a variety of ligands/activators of the peroxisome proliferator-activated receptor (PPAR) on the expression of the superoxide scavenger enzyme, Cu2+,Zn2+-superoxide dismutase (CuZn-SOD), and the superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase in primary cultures of human umbilical vein endothelial cells (HUVEC) and human aorta endothelial cells (HAEC).	Zinc	175-180	peroxisome proliferator activated receptor alpha	Homo sapiens	110-114
11302205-1	2001	DFT calculations were done for the (hydroperoxo)metal complexes with eta1-coordination mode, where metal ions are Fe(III), Al(III), Cu(II) and Zn(II).	Zinc	143-145	secreted phosphoprotein 1	Homo sapiens	69-73
11151508-3	2000	The solid-state structure of the ZnII derivative, NN-SQZnTpCum,Me (C56H69BN8O4Zn), was determined: monoclinic, P2(1)/c, a = 12.5781(12) A, b = 17.7408(17) A, c = 24.440(2) A, alpha = 90.00 degrees, beta = 98.240(2) degrees, gamma = 90.00 degrees, Z = 4.	Zinc	33-37	H3 histone pseudogene 16	Homo sapiens	111-118
11118316-3	2000	Furthermore, expression of Zn transporter 3, ZnT3, which plays to accumulate Zn in synaptic vesicles in the mossy fiber pathway, was markedly reduced in the hippocampal region even in young SAMP10.	Zinc	27-29	solute carrier family 30 member 3	Rattus norvegicus	45-49
11118316-5	2000	The present results suggest that age-dependent deficiencies of Zn in synaptic vesicles of the mossy fiber pathway induced by low expression of ZnT3 cause glutamatergic excitotoxicity in the hippocampal neurons and the deterioration of learning and memory in SAMP10.	Zinc	63-65	solute carrier family 30 member 3	Rattus norvegicus	143-147
11119691-4	2000	To test the hypothesis that the plasma membrane transporter, ZnT-1, modulates Zn(2+) neurotoxicity, we generated stable PC12 cell lines overexpressing wild type or dominant negative forms of rat ZnT-1 (rZnT-1).	Zinc	61-63	solute carrier family 30 member 1	Rattus norvegicus	195-200
11119691-5	2000	Clones T9 and T23 overexpressing wild type rZnT-1 exhibited enhanced Zn(2+) efflux and reduced vulnerability to Zn(2+)-induced death compared to the parental line, whereas clones D5 and D16 expressing dominant negative rZnT-1 exhibited the opposite characteristics.	Zinc	69-71	solute carrier family 30 member 1	Rattus norvegicus	43-49
11127411-8	2000	In Northern blotting experiments, MT-II mRNA levels were induced over a wide range of Zn concentrations during 2-h exposures; specifcally, levels increased by 9- to 115-fold with exposure to 100 microM ZnCl, and by 16- to 311-fold with exposure to 200 microM ZnCl2.	Zinc	86-88	metallothionein 2A	Homo sapiens	34-39
11206070-6	2000	In addition, alpha-synuclein was also rapidly and significantly precipitated by heat in the presence of Zn2+ in vitro, whereas it was not affected by the presence of Ca2+ or Mg2+.	Zinc	104-108	synuclein alpha	Homo sapiens	13-28
11206070-7	2000	Circular dichroism spectra confirmed that alpha-synuclein underwent conformational change in the presence of Zn2+.	Zinc	109-113	synuclein alpha	Homo sapiens	42-57
11155228-4	2000	The zinc ion forms a stable complex with His 119(GH1) on the Mb surface at the equimolar Zn2+ concentration.	Zinc	89-93	somatotropin	Physeter catodon	49-52
11177190-4	2000	Our aim was to show whether measurement of T lymphocyte MT-2A mRNA, using a competitive reverse transcriptase (RT)--polymerase chain reaction (PCR) assay, could indicate Zn status in human subjects in a residential Zn-depletion study.	Zinc	170-172	metallothionein 2A	Homo sapiens	56-61
11177190-4	2000	Our aim was to show whether measurement of T lymphocyte MT-2A mRNA, using a competitive reverse transcriptase (RT)--polymerase chain reaction (PCR) assay, could indicate Zn status in human subjects in a residential Zn-depletion study.	Zinc	215-217	metallothionein 2A	Homo sapiens	56-61
11041860-8	2000	Zn(II) was not only essential but also uniquely qualified for redox regulation of RPA-ssDNA interaction, suggesting that Zn(II)-cysteine coordination is crucial for the zinc-finger function.	Zinc	0-6	replication protein A1	Homo sapiens	82-85
11032778-4	2000	Digital imaging of living mussel haemocytes loaded with Fura-2/AM or Fluo-3/AM showed that Hg2+, Cu2+ and Cd2+ induced a rise in probe fluorescence, whereas up to 200 microM Zn2+ had no effect.	Zinc	174-178	CD2 molecule	Homo sapiens	106-109
11032778-6	2000	Probe calibration yielded [Ca2+]i values characteristic of resting levels in control and Zn2+-exposed cells, and, as expected, indicated Ca2+ homeostasis impairment in cells exposed to Cd2+, Cu2+ and Hg2+.	Zinc	89-93	CD2 molecule	Homo sapiens	185-188
11012675-9	2000	Zn2+, an inhibitor of PSA activity, increased the affinity of the peptides to PSA.	Zinc	0-4	kallikrein related peptidase 3	Homo sapiens	22-25
11012675-9	2000	Zn2+, an inhibitor of PSA activity, increased the affinity of the peptides to PSA.	Zinc	0-4	kallikrein related peptidase 3	Homo sapiens	78-81
11027412-0	2000	Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor.	Zinc	100-102	kallikrein related peptidase 3	Homo sapiens	20-57
11027412-4	2000	Zn(2+)-inhibition of PSA was studied using a chromogenic substrate.	Zinc	0-6	kallikrein related peptidase 3	Homo sapiens	21-24
11027412-8	2000	Zn(2+) ions have a dramatic effect on PSA activity; the data indicate that Zn(2+) is a tight-binding inhibitor of PSA activity.	Zinc	0-5	kallikrein related peptidase 3	Homo sapiens	38-41
11027412-8	2000	Zn(2+) ions have a dramatic effect on PSA activity; the data indicate that Zn(2+) is a tight-binding inhibitor of PSA activity.	Zinc	0-5	kallikrein related peptidase 3	Homo sapiens	114-117
11027412-8	2000	Zn(2+) ions have a dramatic effect on PSA activity; the data indicate that Zn(2+) is a tight-binding inhibitor of PSA activity.	Zinc	0-6	kallikrein related peptidase 3	Homo sapiens	38-41
11027412-8	2000	Zn(2+) ions have a dramatic effect on PSA activity; the data indicate that Zn(2+) is a tight-binding inhibitor of PSA activity.	Zinc	0-6	kallikrein related peptidase 3	Homo sapiens	114-117
11027412-10	2000	The inhibition data indicate that Zn(2+) could regulate PSA activity, which may prove important in the development of efficient inhibitors of PSA activity.	Zinc	34-40	kallikrein related peptidase 3	Homo sapiens	56-59
11027412-10	2000	The inhibition data indicate that Zn(2+) could regulate PSA activity, which may prove important in the development of efficient inhibitors of PSA activity.	Zinc	34-40	kallikrein related peptidase 3	Homo sapiens	142-145
11018678-1	2000	Membrane fusion between uncharged lipid vesicles can be triggered by the peptide sequence "B18" from the fertilization protein "bindin", but it only proceeds efficiently in the presence of Zn(2+) ions.	Zinc	189-191	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	91-94
11018678-3	2000	The complex formation of Zn(2+) with the central histidine-rich motif of B18 appears to shift the secondary structure away from a beta-sheet towards an alpha-helical conformation.	Zinc	25-27	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	73-76
11018678-9	2000	Binding of the B18 peptide in the presence of Zn(2+) effectively renders the membrane surface more hydrophobic, thus allowing fusion to proceed.	Zinc	46-52	NADH:ubiquinone oxidoreductase subunit B7	Homo sapiens	15-18
10986126-9	2000	Additionally, MMP-1 and MMP-13 exhibit different dynamic properties for the active-site loop and the structural Zn-binding region.	Zinc	112-114	matrix metallopeptidase 1	Homo sapiens	14-19
12541706-1	2000	HPLC was used in the investigation of the reaction behavior of Cd2+, Pb2+, Cu2+ and Zn2+ with mesotetrakis (4-hydroxy-phenyl)porphine (THPP) and chromatographic behavior of their complexes.	Zinc	84-88	CD2 molecule	Homo sapiens	63-66
10913283-2	2000	Human GlxI, for which the structure is known, is active in the presence of Zn(2+).	Zinc	75-77	glyoxalase I	Homo sapiens	6-10
10908293-6	2000	The metal-ion chelator, phenantroline, which in the beta(2)-adrenergic receptor increased both the potency and the agonistic efficacy of Zn(2+) or Cu(2+) in complex with the chelator, also bound to the metal-ion site-engineered NK(1) receptor, but here the metal-ion chelator complex instead acted as a pure antagonist.	Zinc	137-139	tachykinin receptor 1	Homo sapiens	228-242
11097056-1	2000	The hydrolytic activity of the 1,3,5-triaminocyclohexane derivatives TACH, TACI and TMCA complexed to Zn(II) and Cu(II) towards a model phosphoric ester and plasmid DNA has been evaluated by means of spectroscopic and gel-electrophoresis techniques.	Zinc	102-108	TNF receptor superfamily member 13B	Homo sapiens	75-79
10751401-1	2000	NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(2+), Zn(2+), Mn(2+), Cu(2+), Cd(2+), Co(2+), Ni(2+), and Pb(2+), and mediates active proton-coupled transport.	Zinc	244-246	solute carrier family 11 member 2	Homo sapiens	0-6
10751401-1	2000	NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(2+), Zn(2+), Mn(2+), Cu(2+), Cd(2+), Co(2+), Ni(2+), and Pb(2+), and mediates active proton-coupled transport.	Zinc	244-246	solute carrier family 11 member 2	Homo sapiens	8-58
10751401-1	2000	NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(2+), Zn(2+), Mn(2+), Cu(2+), Cd(2+), Co(2+), Ni(2+), and Pb(2+), and mediates active proton-coupled transport.	Zinc	244-246	solute carrier family 11 member 2	Homo sapiens	60-64
10887113-6	2000	Furthermore, we have confirmed that HKa but not HK bound to uPAR and to the truncated 2-domain form of uPAR lacking domain 1 in a Zn(2+)-dependent manner.	Zinc	130-132	plasminogen activator, urokinase receptor	Homo sapiens	103-107
11051600-1	2000	We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with thyroid disorder.	Zinc	82-84	leptin	Homo sapiens	53-59
11051600-7	2000	However, a weak correlation (r = 0.28, p = 0.032) between leptin and the Zn/Cu ratio was found from the pooled data of all participants and retained after adjustment for adiposity.	Zinc	73-75	leptin	Homo sapiens	58-64
10885393-3	2000	The difference in the reaction rates is attributed to steric effects due to the high molecular size in the case of BSA and to effects of metal coordination proper as well as to steric effects associated with the closed dual shell-like structure resulting from the tight coordination of the thiolate groups with Zn2+ in MT1.	Zinc	311-315	metallothionein 1I, pseudogene	Homo sapiens	319-322
10812846-5	2000	The inhibition by Cd2+ was relieved by the addition of Zn2+ at much lower concentrations than that of Cd2+.	Zinc	55-59	CD2 molecule	Homo sapiens	18-21
10675536-4	2000	The metal binding abilities of the Cu- and Zn-MTN complexes conformed in vivo, as well as the features of the Cd- and Cu-aggregates produced by metal replacement in vitro, have been determined by atomic emission spectrometry, circular dichroism and electrospray ionization mass spectrometry.	Zinc	43-45	Metallothionein B	Drosophila melanogaster	46-49
10608837-6	1999	HEX1-N2 is approximately 3-fold less active in Mn(2+)-containing buffers and exhibits &lt;5% activity in the presence of Co(2+), Zn(2+), or Ca(2+).	Zinc	129-135	exonuclease 1	Homo sapiens	0-4
10608803-2	1999	The Escherichia coli ZntR protein, a homologue of MerR, has recently been shown to mediate Zn(II)-responsive regulation of zntA, a gene involved in Zn(II) detoxification.	Zinc	148-154	activator/repressor of mer operon	Escherichia coli	50-54
10608803-3	1999	To determine whether the MerR DNA distortion mechanism is conserved among MerR family members, we have purified ZntR to homogeneity and shown that it is a zinc receptor that is necessary and sufficient to stimulate Zn-responsive transcription at the zntA promoter.	Zinc	112-114	activator/repressor of mer operon	Escherichia coli	25-29
10551873-9	1999	MT4-MMP is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A.	Zinc	35-37	matrix metallopeptidase 17	Homo sapiens	0-7
10542287-6	1999	Zn(2+) induced a sustained increase in phosphorylation of the alpha subunit of the translation eukaryotic initiation factor-2 (eIF-2alpha), whereas it triggered a transient increase in phosphorylation of eukaryotic elongation factor-2 (eEF-2).	Zinc	0-2	eukaryotic translation elongation factor 2	Mus musculus	204-234
10542287-6	1999	Zn(2+) induced a sustained increase in phosphorylation of the alpha subunit of the translation eukaryotic initiation factor-2 (eIF-2alpha), whereas it triggered a transient increase in phosphorylation of eukaryotic elongation factor-2 (eEF-2).	Zinc	0-2	eukaryotic translation elongation factor 2	Mus musculus	236-241
10542287-8	1999	Moreover, Zn(2+) was less effective than glutamate to increase eEF-2 phosphorylation, whereas it induced a more profound inhibition of protein synthesis.	Zinc	10-16	eukaryotic translation elongation factor 2	Mus musculus	63-68
10541961-0	1999	Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease.	Zinc	6-12	protein interacting with PRKCA 1	Homo sapiens	70-74
10502303-4	1999	pp52(S6K) was inhibited by fluoride (IC(50) approximately 60 mM), but was relatively insensitive to beta-glycerolphosphate, EGTA, dithiothreitol, spermine, heparin, NaCl, and metal ions such as Mn(2+), Zn(2+), and Ca(2+).	Zinc	202-204	ribosomal protein S6 kinase B1	Homo sapiens	5-8
10462702-5	1999	In this investigation, by immunochemical and morphological analysis, we studied the effect of stabilization with different divalent cations (Zn(2+), Cu(2+), Cd(2+)) on the distribution of lamin A and B1 in the nuclear matrix obtained from K562 human erythroleukemia cells.	Zinc	141-147	lamin B1	Homo sapiens	188-202
10517800-14	1999	Systematic mutation of extracellular histidine residues in the GlyR alpha1 subunit revealed that mutations H107A or H109A completely abolished inhibition of glycine-gated currents by Zn2+.	Zinc	183-187	glycine receptor alpha 1	Homo sapiens	63-74
10517800-16	1999	Thus, H107 and H109 in the extracellular domain of the human GlyR alpha1 subunit are major determinants of the inhibitory Zn2+ binding site.	Zinc	122-126	glycine receptor alpha 1	Homo sapiens	61-72
10517800-18	1999	An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes.	Zinc	18-22	glycine receptor alpha 1	Homo sapiens	174-185
10517800-18	1999	An examination of Zn2+ co-ordination in metalloenzymes revealed that the histidine- hydrophobic residue-histidine motif found to be responsible for binding Zn2+ in the human GlyR alpha1 subunit is also shared by some of these enzymes.	Zinc	156-160	glycine receptor alpha 1	Homo sapiens	174-185
10517800-19	1999	Further comparison of the structure and location of this motif with a generic model of the GlyR alpha1 subunit suggests that H107 and H109 participate in the formation of the inhibitory Zn2+ binding site at the apex of a beta sheet in the N-terminal extracellular domain.	Zinc	186-190	glycine receptor alpha 1	Homo sapiens	91-102
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	NFKB inhibitor alpha	Rattus norvegicus	87-102
10629862-6	1999	Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells.	Zinc	283-287	NFKB inhibitor alpha	Rattus norvegicus	162-177
10510462-0	1999	Modulatory activity of extracellular H+ and Zn2+ on ATP-responses at rP2X1 and rP2X3 receptors.	Zinc	44-48	purinergic receptor P2X 3	Rattus norvegicus	79-84
10510462-1	1999	1 The modulatory activity of extracellular H+ and Zn2+ was examined on ATP-responses at rat P2X1 (rP2X1) and rat P2X3 (rP2X3) receptors expressed in Xenopus oocytes and studied under voltage-clamp conditions.	Zinc	50-54	purinergic receptor P2X 3	Rattus norvegicus	113-117
10510462-1	1999	1 The modulatory activity of extracellular H+ and Zn2+ was examined on ATP-responses at rat P2X1 (rP2X1) and rat P2X3 (rP2X3) receptors expressed in Xenopus oocytes and studied under voltage-clamp conditions.	Zinc	50-54	purinergic receptor P2X 3	Rattus norvegicus	119-124
10510462-10	1999	5 Extracellular Zn2+ weakly potentiated ATP-responses at rP2X3 receptors (EC50 value, 11+/-1 microM).	Zinc	16-20	purinergic receptor P2X 3	Rattus norvegicus	57-62
10510462-13	1999	ATP activity at rP2X3 receptors was less sensitive to H+-inhibition and, in contrast, was potentiated by Zn2+ in a pH-independent manner.	Zinc	105-109	purinergic receptor P2X 3	Rattus norvegicus	16-21
10407157-0	1999	Ca(2+) and Zn(2+) binding properties of peptide substrates of vertebrate collagenase, MMP-1.	Zinc	11-17	matrix metallopeptidase 1	Homo sapiens	86-91
10407157-1	1999	To understand the role of Ca(2+) in vertebrate in the structure and action of collagenase, we have examined peptides that interact with recombinant human fibroblast collagenase for their affinities towards Ca(2+) and Zn(2+) in a non-polar solvent.	Zinc	217-223	matrix metallopeptidase 1	Homo sapiens	154-176
10331855-7	1999	[Ca2+]i-chelating BAPTA-AM (5 microM) and/or DNase gamma-inhibiting Zn2+ (0.5 mM) inhibited approximately 50% of induced apoptosis and DNA-laddering, indicating a 50% participation of Ca2+/Mg2+-dependent DNase gamma.	Zinc	68-72	deoxyribonuclease 1 like 3	Homo sapiens	45-56
10331855-7	1999	[Ca2+]i-chelating BAPTA-AM (5 microM) and/or DNase gamma-inhibiting Zn2+ (0.5 mM) inhibited approximately 50% of induced apoptosis and DNA-laddering, indicating a 50% participation of Ca2+/Mg2+-dependent DNase gamma.	Zinc	68-72	deoxyribonuclease 1 like 3	Homo sapiens	204-215
10201397-2	1999	Thiophilic metal ions such as Mn2+, Zn2+ or Cd2+ rescue the &gt;10(3)-fold inhibitory effect of sulfur substitution of the 3"-oxygen leaving group but do not effectively rescue the effect of sulfur substitution of the nonbridging pro-Sp phosphoryl oxygen.	Zinc	36-40	protein S (beta) pseudogene	Homo sapiens	230-236
9873037-8	1999	ORF-74 could serve as a target for the development of non-peptide inverse agonist drugs as demonstrated by the effect of Zn2+ on the metal ion site-engineered receptor.	Zinc	121-125	ORF74	Human gammaherpesvirus 8	0-6
9808768-4	1998	ECE-1 consists of a short N-terminal cytoplasmic tail, a transmembrane hydrophobic domain, and a large extracellular domain containing the catalytic site with a conserved Zn-binding motif.	Zinc	171-173	endothelin converting enzyme 1	Homo sapiens	0-5
9849872-1	1998	In the wild-type tachykinin NK3A receptor histidyl residues are present at two positions in TM-V, V:01 and V:05, at which Zn2+ functions as an antagonist in NK1 and kappa-opioid receptors with engineered metal-ion sites.	Zinc	122-126	tachykinin receptor 1	Homo sapiens	157-160
9849872-3	1998	[MePhe7]neurokinin B bound to the NK3A receptor in a two-component mode of which Zn2+ eliminated the subnanomolar binding mode but induced a higher binding capacity of the nanomolar binding mode.	Zinc	81-85	tachykinin precursor 3	Homo sapiens	8-20
9849872-6	1998	It is concluded that physiological concentrations of Zn2+ have a positive modulatory effect on the binding and function of neurokinin B on the NK3A receptor through a bis-His site in TM-V.	Zinc	53-57	tachykinin precursor 3	Homo sapiens	123-135
9778374-2	1998	Native GIF contains 4 Cu(I) and three Zn(II) ions organized in homometallic metal-thiolate clusters.	Zinc	38-44	cobalamin binding intrinsic factor	Homo sapiens	7-10
9790586-5	1998	Both hip1-272 cells and the null mutant exhibited low tolerance to divalent cations such as Co2+, Ni2+, Zn2+, and Cu2+.	Zinc	104-108	histidine permease	Saccharomyces cerevisiae S288C	5-9
10696239-4	1998	Recently, the yeast two-hybrid system has identified hASNA-I as a cellular partner of metallothionein II suggesting an additional role in Zn homeostasis and cellular detoxification.	Zinc	138-140	metallothionein 2A	Homo sapiens	86-104
9705294-0	1998	Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.	Zinc	30-34	glyoxalase I	Homo sapiens	78-90
9705294-1	1998	The Zn2+ ligands glutamate 99 and glutamate 172 in the active site of human glyoxalase I were replaced, each in turn, by glutamines by site-directed mutagenesis to elucidate their potential significance for the catalytic properties of the enzyme.	Zinc	4-8	glyoxalase I	Homo sapiens	76-88
29711060-1	1998	MP2 calculations show that the D h isoelectronic dicarbonyl complexes [M(CO)2 ]n (Mn =Rh- , Pd0 , Cu+ , Ag+ , Au+ , Zn2+ , Cd2+ , Hg2+ ) depicted in structure 1 can be classified as classical or nonclassical depending on whether the metal-carbon bond lengths decrease or increase when weak, anionic ligands approach the metal centers.	Zinc	116-119	tryptase pseudogene 1	Homo sapiens	0-3
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2D	Homo sapiens	359-363
9698310-3	1998	Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature NR1 transcript and the NMDA receptor complex contains the NR2A or NR2B subunits; exon 5 has little effect on Zn2+ inhibition of receptors that contain NR2C and NR2D.	Zinc	308-312	glutamate ionotropic receptor NMDA type subunit 2D	Homo sapiens	359-363
9649414-0	1998	Real-time observation of conformational fluctuations in Zn-substituted myoglobin by time-resolved transient hole-burning spectroscopy.	Zinc	56-58	myoglobin	Homo sapiens	71-80
9649612-6	1998	CD-1 mice were pretreated with saline or Zn (20 and 40 mg/kg) on GD 8.5 and 9.5.	Zinc	41-43	CD1 antigen complex	Mus musculus	0-4
9476915-8	1998	Dephosphorylation of NDPK was stimulated by the addition of Mg2+, Mn2+, and Co2+ (but not Zn2+ or Ca2+).	Zinc	90-94	cytidine/uridine monophosphate kinase 2	Homo sapiens	21-25
9503325-3	1998	To investigate underlying receptor function we studied Zn2- effects on macroscopic and single-channel currents of recombinant alpha 1 beta 2 and alpha 1 beta 2 gamma 2 receptors expressed heterologously in HEK-293 cells using the patch-clamp technique and rapid solution changes.	Zinc	55-58	adrenoceptor alpha 1D	Homo sapiens	126-167
9503325-5	1998	Zn2+ present for &gt; 60 s (constant) inhibited peak, GABA (5 microM)-triggered currents of alpha 1 beta 2 receptors in a concentration-dependent manner (inhibition equation parameters: concentration at half-amplitude (IC50) = 0.94 microM; slope related to Hill coefficient, S = 0.7) that was unaffected by GABA concentration.	Zinc	0-4	adrenoceptor alpha 1D	Homo sapiens	92-99
9503325-6	1998	The gamma 2 subunit (alpha 1 beta 2 gamma 2 receptor) reduced Zn2+ sensitivity more than fiftyfold (IC50 = 51 microM, S = 0.86); increased GABA concentration (100 microM) antagonized inhibition by reducing apparent affinity (IC50 = 322 microM, S = 0.79).	Zinc	62-66	adrenoceptor alpha 1D	Homo sapiens	21-28
9503325-7	1998	Zn2+ slowed macroscopic gating of alpha 1 beta 2 receptors by inducing a novel slow exponential component in the activation time course and suppressing a fast component of control desensitization.	Zinc	0-4	adrenoceptor alpha 1D	Homo sapiens	34-41
9503325-8	1998	For alpha 1 beta 2 gamma 2 receptors, Zn2+ accelerated a fast component of apparent desensitization.	Zinc	38-42	adrenoceptor alpha 1D	Homo sapiens	4-11
9503325-10	1998	Zn2+ preincubations lasting up to 10 s markedly increased current depression and activation slowing of alpha 1 beta 2 receptors, but had little effect on currents from alpha 1 beta 2 gamma 2 receptors.	Zinc	0-4	adrenoceptor alpha 1D	Homo sapiens	103-110
9503325-16	1998	Zn2+ (500 microM) depression of previously activated current amplitudes (% control) for alpha 1 beta 2 gamma 2 receptors was independent of GABA concentration (5 microM, 13.2 +/- 0.72%; 100 microM, 12.2 +/- 2.9%, P &lt; 0.8, n = 5).	Zinc	0-4	adrenoceptor alpha 1D	Homo sapiens	88-95
9503325-19	1998	Inhibition onset was also biexponential for preactivated alpha 1 beta 2 receptors with current depression more than fourfold less sensitive (5 microM GABA, IC50 = 3.8 microM, S = 0.84) relative to that in constant Zn2+.	Zinc	214-218	adrenoceptor alpha 1D	Homo sapiens	57-64
14646495-7	1998	The inhibition profiles by aurintricarboxylic acid, sodium citrate and divalent metal ions such as Co2+, Ni2+, Cu2+ and Zn2+ were similar to those of mammalian DNase gamma.	Zinc	120-124	deoxyribonuclease 1 like 3	Homo sapiens	160-171
9308366-9	1998	Cu(I) triggering may involve a metal exchange reaction converting Ace1 from a Zn(II)-specific conformer to a clustered Cu(I) conformer.	Zinc	78-84	Cup2p	Saccharomyces cerevisiae S288C	66-70
9335586-4	1997	Overexpression of VPS45 was able to completely suppress the Zn2+ sensitivity and partially suppress the carboxypeptidase Y deficiency.	Zinc	60-64	Vps45p	Saccharomyces cerevisiae S288C	18-23
9202323-7	1997	The binding of 125I-A beta(1-42) to alpha2M is enhanced by micromolar concentrations of Zn2+ (but not Ca2+) and is inhibited by noniodinated A beta(1-42) and A beta(1-40) but not by the reverse peptide A beta(40-1) or the cytokines interleukin 1beta or interleukin 2.	Zinc	88-92	alpha-2-macroglobulin	Homo sapiens	36-43
9184145-8	1997	Conversely, the presence of Zn2+ weakened the binding of HRG to C1q (Kd increased from 7.80 to 29.3 nM).	Zinc	28-32	complement C1q A chain	Homo sapiens	64-67
9151945-4	1997	As for P2X4 purinoceptors, the ATP-activated current was, however, enhanced after the washout of Zn2+ (100 microM) or Cd2+ (1 mM).	Zinc	97-101	purinergic receptor P2X, ligand gated ion channel, 4 L homeolog	Xenopus laevis	7-11
9142919-9	1997	Although purified salivary PSP from C3H/HeJ or BALB/c mice fails to affect amylase enzyme activity in in vitro assays, PSP bound to whole bacteria in a Zn2+-dependent manner.	Zinc	152-156	BPI fold containing family A, member 2	Mus musculus	119-122
9108290-1	1997	The Bacillus subtilis 168 RecR protein bound to duplex DNA in the presence of ATP and divalent cations (Mg2+ and Zn2+) was visualized by electron microscopy as a nearly spherical particle.	Zinc	113-117	recA filament-DNA complex stabilisation factor	Bacillus subtilis subsp. subtilis str. 168	26-30
9065685-9	1997	The RPA1 subunits of Drosophila melanogaster and lower eukaryotes share an additional Zn-binding motif at the N-terminus with archaebacterial and RPC1 subunits, testifying to the complex evolutionary relationships among the RNA polymerases.	Zinc	86-88	RNA polymerase I subunit	Drosophila melanogaster	4-8
9010776-6	1996	Analyses of proteolytic fragments suggested that both ABP-1 and ABP-2 have Zn fingers showing high similarity with that of AEF-1, a transcriptional repressor of the Drosophila melanogaster alcohol dehydrogenase gene that binds to a sequence very similar to that binding ABP-1 and ABP-2.	Zinc	75-77	Actin binding protein 1	Drosophila melanogaster	54-59
9010776-6	1996	Analyses of proteolytic fragments suggested that both ABP-1 and ABP-2 have Zn fingers showing high similarity with that of AEF-1, a transcriptional repressor of the Drosophila melanogaster alcohol dehydrogenase gene that binds to a sequence very similar to that binding ABP-1 and ABP-2.	Zinc	75-77	lava lamp	Drosophila melanogaster	64-69
9010776-6	1996	Analyses of proteolytic fragments suggested that both ABP-1 and ABP-2 have Zn fingers showing high similarity with that of AEF-1, a transcriptional repressor of the Drosophila melanogaster alcohol dehydrogenase gene that binds to a sequence very similar to that binding ABP-1 and ABP-2.	Zinc	75-77	Adult enhancer factor 1	Drosophila melanogaster	123-128
9010776-7	1996	We isolated a candidate cDNA for ABP-2, and the protein it encoded contained nine Zn fingers and regions rich in alanine, glutamine, serine/threonine, glycine, histidine, and asparagine.	Zinc	82-84	lava lamp	Drosophila melanogaster	33-38
9013335-6	1996	These neurotoxins are Zn(2+)-dependent proteases that cleave VAMP/synaptobrevin and SNAP-25, two proteins which can form a ternary complex (termed the SNARE complex) with syntaxin and have been implicated in the docking of synaptic vesicles at the plasma membrane.	Zinc	22-24	synaptosome associated protein 25	Homo sapiens	84-91
8945632-4	1996	The expression of the dexamethasone-inducible transforming ras gene alone or in combination with the Zn-inducible SV40LTag mimicked the IGF-I effect inducing UCP expression and IGF-I did not induce it further.	Zinc	101-103	insulin-like growth factor 1	Rattus norvegicus	136-141
8945632-4	1996	The expression of the dexamethasone-inducible transforming ras gene alone or in combination with the Zn-inducible SV40LTag mimicked the IGF-I effect inducing UCP expression and IGF-I did not induce it further.	Zinc	101-103	insulin-like growth factor 1	Rattus norvegicus	177-182
8921887-3	1996	The cysteine residues in the putative DNA binding domain, which may interact with Zn2+ ions to form zinc fingers, are 100% conserved between the two species, indicating that the novel zinc-finger structures in DAX1 may be functional.	Zinc	82-86	nuclear receptor subfamily 0, group B, member 1	Mus musculus	210-214
8858095-7	1996	In the present study we show that, in contrast to its effects in rabbit cardiomyocytes, mitochondria, and SMP in which Zn2+ fully blocked IF1-mediated ATPase inhibition, Zn2+ actually enhanced ATPase inhibition in rat cardiomyocytes, although the extent of this effect was limited by the low level of IF1 in rat cardiomyocytes.	Zinc	170-174	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	301-304
8841125-2	1996	Temperature dependent splitting also occurs for zinc cytochrome c, a derivative in which Fe has been replaced by Zn; at 10 K, the peaks in the Q0,0 band region occur at 17 106 and 16 996 cm-1.	Zinc	113-115	cytochrome c, somatic	Equus caballus	53-65
8706670-3	1996	Native Cu, ZN-GIF and the Zn2+ -substituted and Cd2+-substituted metalloforms have been characterized by means of electronic-absorption, CD, magnetic-circular-dichroism (MCD) and low-temperature (77 K) Cu(I)-luminescence spectroscopy.	Zinc	11-13	cobalamin binding intrinsic factor	Homo sapiens	14-17
8706670-4	1996	Analysis of the metal-induced-charge-transfer transitions below 300 nm in the electronic-absorption and CD spectra of Cu, ZN-GIF revealed spectral features characteristic of metal-thiolate coordination.	Zinc	122-124	cobalamin binding intrinsic factor	Homo sapiens	125-128
8706670-6	1996	The 77-K luminescence spectrum of Cu, ZN-GIF revealed two emissive bands at approximately 420 nm and 570 nm, which were reported also for CU4 clusters in mammalian Cu8-metallothionein.	Zinc	38-40	cobalamin binding intrinsic factor	Homo sapiens	41-44
8665956-7	1996	The bindings of Sg II to both iPr2P-PSA and PCI were influenced by pH, ionic strength, heparin, dextran sulfate, and divalent cations, particularly by Zn2+.	Zinc	151-155	semenogelin 2	Homo sapiens	16-21
8740964-0	1996	Influence of zinc(II) binding on the structure of bovine alpha-lactalbumin.	Zinc	13-21	lactalbumin alpha	Bos taurus	57-74
8740964-1	1996	The effect of Zn(II) binding on the structure of bovine alpha-lactalbumin (LA) was investigated.	Zinc	14-20	lactalbumin alpha	Bos taurus	56-73
8740964-2	1996	alpha-Lactalbumin, a regulatory subunit of lactose synthase, binds Ca(II) and Zn(II) at different sites in a mutually non-exclusive manner.	Zinc	78-84	lactalbumin alpha	Bos taurus	0-59
8634288-12	1996	The sequence homology between AMT1, ACE1, and MAC1 in the N-terminal 42 residues suggests that ACE1 and MAC1 will, likewise, contain N-terminal Zn modules.	Zinc	144-146	Cup2p	Saccharomyces cerevisiae S288C	95-99
7592939-5	1995	PSA is 27-40% homologous to several known Zn(2+)-binding aminopeptidases including aminopeptidase N.	Zinc	42-48	alanyl (membrane) aminopeptidase	Mus musculus	83-99
7568234-1	1995	To explore the relationship between mitochondrial aspartate aminotransferase (mAspAT; EC 2.6.1.1) and plasma membrane fatty acid-binding protein (FABPpm) and their role in cellular fatty acid uptake, 3T3 fibroblasts were cotransfected with plasmid pMAAT2, containing a full-length mAspAT cDNA downstream of a Zn(2+)-inducible metallothionein promoter, and pFR400, which conveys methotrexate resistance.	Zinc	309-311	glutamic-oxaloacetic transaminase 2	Homo sapiens	146-152
7568234-8	1995	The overall increase in Vmax between pFR400 and pFR400/pMAAT2 in the presence of Zn2+ was 10.4-fold (P &lt; 0.01) and was highly correlated (r = 0.99) with expression of FABPpm in plasma membranes as determined by Western blotting.	Zinc	81-85	glutamic-oxaloacetic transaminase 2	Homo sapiens	170-176
8540621-2	1995	Formation constants (log K) for the Cd2+ and Zn2+ complexes of PLC estimated by spectrophotometric titration were 8.0 +/- 0.8 and 9.5 +/- 0.5, respectively.	Zinc	45-49	CD2 molecule	Homo sapiens	36-39
7673133-4	1995	The Zn(2+)-binding parameters of S100A3 were studied by equilibrium gel filtration and yielded a stoichiometry of four Zn2+ per monomer with a [Zn2+]0.5 of 11 microM and a Hill coefficient of 1.4 at physiological ionic strength.	Zinc	4-10	S100 calcium binding protein A3	Homo sapiens	33-39
7673133-4	1995	The Zn(2+)-binding parameters of S100A3 were studied by equilibrium gel filtration and yielded a stoichiometry of four Zn2+ per monomer with a [Zn2+]0.5 of 11 microM and a Hill coefficient of 1.4 at physiological ionic strength.	Zinc	119-123	S100 calcium binding protein A3	Homo sapiens	33-39
7673133-12	1995	Of the 10 Cys residues in S100A3, 5 only are free thiols, and accessible to 5,5"-dithiobis(2-nitro-benzoic acid); they display a high reactivity in the metal-free and Ca2+ form, but a 20-fold lowered reactivity in the Zn2+ form of S100A3.	Zinc	218-222	S100 calcium binding protein A3	Homo sapiens	26-32
7673133-14	1995	Our data indicate that Ca2+ and Zn2+ do not bind to the same sites and that under physiological conditions S100A3 is a Zn(2+)-binding rather than a Ca(2+)-binding protein; nevertheless, very specific conformational changes are introduced by either Ca2+ or Zn2+.	Zinc	32-36	S100 calcium binding protein A3	Homo sapiens	107-113
7673133-14	1995	Our data indicate that Ca2+ and Zn2+ do not bind to the same sites and that under physiological conditions S100A3 is a Zn(2+)-binding rather than a Ca(2+)-binding protein; nevertheless, very specific conformational changes are introduced by either Ca2+ or Zn2+.	Zinc	119-125	S100 calcium binding protein A3	Homo sapiens	107-113
7673133-14	1995	Our data indicate that Ca2+ and Zn2+ do not bind to the same sites and that under physiological conditions S100A3 is a Zn(2+)-binding rather than a Ca(2+)-binding protein; nevertheless, very specific conformational changes are introduced by either Ca2+ or Zn2+.	Zinc	256-260	S100 calcium binding protein A3	Homo sapiens	107-113
7673133-15	1995	Since no Zn(2+)-binding motif of known structure was identified in the primary sequence of S100A3, the results are suggestive for a novel Zn(2+)-binding motif.	Zinc	138-144	S100 calcium binding protein A3	Homo sapiens	91-97
7630723-0	1995	Zinc(II) ions selectively interact with DNA sequences present at the TFIIIA binding site of the Xenopus 5S-RNA gene.	Zinc	0-8	general transcription factor 3A L homeolog	Xenopus laevis	69-75
7718580-1	1995	Human and mouse metallothionein-3 (MT-3) molecules exhibit the same metal binding stoichiometry with Zn(II), Cd(II), or Cu(I) as MT-1 or MT-2 molecules, suggesting that MT-3 consists of two domains enfolding separate polymetallic clusters.	Zinc	101-107	metallothionein 3	Mus musculus	16-33
7718580-1	1995	Human and mouse metallothionein-3 (MT-3) molecules exhibit the same metal binding stoichiometry with Zn(II), Cd(II), or Cu(I) as MT-1 or MT-2 molecules, suggesting that MT-3 consists of two domains enfolding separate polymetallic clusters.	Zinc	101-107	metallothionein 3	Mus musculus	35-39
7718580-4	1995	Zn(II) complexes of human and mouse MT-3 inhibit the survival of rat cortical neurons cultured in the presence of an Alzheimer"s disease brain extract.	Zinc	0-6	metallothionein 3	Mus musculus	36-40
7850808-5	1995	Expression of mutant p21ras in these cells, induced by Zn2+, resulted in an approximate 30-fold increase in the IGF-1 production rate, reaching a level exceeding that of human embryo fibroblasts.	Zinc	55-59	HRas proto-oncogene, GTPase	Homo sapiens	21-27
7779539-8	1995	Negative correlations were found between Zn and beta 2 microglobulin (p &lt; 0.005) and between Se and beta 2 microglobulin (p &lt; 0.05).	Zinc	41-43	beta-2-microglobulin	Homo sapiens	48-68
7881739-12	1995	Low concentrations of Zn2+ blocked IK(-Ckm) while having little effect on IK(DR).	Zinc	22-26	creatine kinase M-type	Cavia porcellus	39-42
7881739-13	1995	Zn2+ (40 microM) caused a 77 +/- 1% reduction of IK(-Ckm) at -30 mV (n = 4) but IK(DR) was inhibited by only 10 +/- 3% at the same voltage (n = 4).	Zinc	0-4	creatine kinase M-type	Cavia porcellus	53-56
7881739-21	1995	These experiments indicate that (-)Ckm-activated K channels are more sensitive to inhibition by Ba2+and Zn2+ and pass inward Rb+ current less well than delayed rectifier K channels.	Zinc	104-108	creatine kinase M-type	Cavia porcellus	35-38
7961855-13	1994	Zinc binding to calgranulin C induces a remarkable increase in the protein affinity for calcium; in the absence of zinc, the protein binds 1 Ca2+/monomer with a binding constant of about 2 x 10(4) M-1, whereas the Zn(2+)-loaded form binds 2 Ca2+/monomer with Ka values of approximately 3 x 10(7) and 6 x 10(4) M-1.	Zinc	214-220	S100 calcium binding protein A12	Sus scrofa	16-29
7970873-8	1994	The reduced production of IL-4 and IFN-gamma, the reduced peripheral eosinophilia and reduced serum levels of IgE and IgG1 in Zn- mice were attributed to the zinc deficiency, whereas the reduced delayed type hypersensitivity response to parasite antigen and reduced production of IL-5 were in certain instances attributed to reduced energy intake rather than zinc deficiency.	Zinc	126-128	interleukin 5	Mus musculus	280-284
7938909-6	1994	Furthermore, reduction of Fe and Zn contents in the liver of the PBC patients indicated the possible relationship of ceruloplasmin to Fe and Zn metabolism as well as Cu metabolism.	Zinc	33-35	ceruloplasmin	Homo sapiens	117-130
7938909-6	1994	Furthermore, reduction of Fe and Zn contents in the liver of the PBC patients indicated the possible relationship of ceruloplasmin to Fe and Zn metabolism as well as Cu metabolism.	Zinc	141-143	ceruloplasmin	Homo sapiens	117-130
7945790-7	1994	The present work examines Co2+ binding to bovine alpha-lactalbumin, where for this analog of Zn2+, multiple binding sites were also found from spectrofluorimetric titrations.	Zinc	93-97	complement C2	Homo sapiens	26-29
7945790-7	1994	The present work examines Co2+ binding to bovine alpha-lactalbumin, where for this analog of Zn2+, multiple binding sites were also found from spectrofluorimetric titrations.	Zinc	93-97	lactalbumin alpha	Bos taurus	49-66
7945790-10	1994	Fluorescence energy transfer measurements between Tb3+ in the strong calcium site to Co2+ in the strong Zn2+ site gave a distance in the range of 14-18 A, which was in excellent agreement with recent crystallographic data for human alpha-lactalbumin [Ren et al.	Zinc	104-108	complement C2	Homo sapiens	85-88
7510696-11	1994	The induction of PDE3 message by cAMP was blocked when the L6 transfectants were treated with Zn2+ to induce protein kinase A inhibition.	Zinc	94-98	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	17-21
8264229-8	1993	Expression of transgenes in MT-SGF mice and MT-MGF mice was induced by feeding animals Zn at 2 months of age.	Zinc	87-89	kit ligand	Mus musculus	47-50
8142006-4	1993	In the presence of alpha-lactalbumin (i.e., lactose synthase), the Mn(II)-activation is biphasic and the initial phase is inhibited by increasing concentrations of Zn(II).	Zinc	164-166	beta-1,4-galactosyltransferase 1	Homo sapiens	44-60
8142006-6	1993	The results suggest that Zn(II) binding to alpha-lactalbumin effects lactose synthase.	Zinc	25-31	beta-1,4-galactosyltransferase 1	Homo sapiens	69-85
8142006-7	1993	Kinetically, Zn(II) induces a decrease in both the Km(app) and Vm for Mn(II), which results in an apparent increase, followed by a decrease, in lactose synthase activity at Mn(II) concentrations below saturation of the first [Mn(II)] binding site.	Zinc	13-19	beta-1,4-galactosyltransferase 1	Homo sapiens	144-160
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	beta-1,4-galactosyltransferase 1	Homo sapiens	90-106
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	beta-1,4-galactosyltransferase 1	Homo sapiens	246-262
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	213-215	beta-1,4-galactosyltransferase 1	Homo sapiens	90-106
8332909-0	1993	NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1.	Zinc	43-45	GATA binding protein 1 (globin transcription factor 1)	Gallus gallus	79-85
7679115-4	1993	Expression in Xenopus oocytes demonstrated that the single protein encoded by the cloned cDNA possesses the electrophysiological and pharmacological properties characteristic of the NMDA receptor, including Ca2+ permeability, voltage-dependent Mg2+ block, and inhibition by selective antagonists such as Zn2+ and channel blockers.	Zinc	304-308	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	182-195
8425230-5	1993	Inhibition of mRNA and protein synthesis and addition of the PKC-inhibitor H-7, Zn2+ ions, and IL-4 counteracted the IL-2 effect.	Zinc	80-84	interleukin 2	Mus musculus	117-121
1489830-3	1992	Carboxypeptidase H is a thiol-dependent metalloenzyme and contains a Zn2+ ion in its active center.	Zinc	69-73	carboxypeptidase E	Homo sapiens	0-18
1331763-11	1992	Interestingly, Zn2+, an other inhibitor of beta ARK, totally prevented 5-HT4-induced desensitization.	Zinc	15-19	G protein-coupled receptor kinase 2	Mus musculus	43-51
1456953-4	1992	Although addition of 200 microM EDTA for 24 hr decreased the c-myc mRNA level of HL-60 cells, coaddition of 20 microM of Zn also reversed this effect on c-myc mRNA level.	Zinc	121-123	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	153-158
1456953-6	1992	These findings suggest that Zn deficiency suppresses c-myc gene transcription which is followed by suppression of proliferation and induction of differentiation of HL-60 cells.	Zinc	28-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	53-58
1633859-0	1992	A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.	Zinc	69-71	melanotransferrin	Homo sapiens	53-56
1633859-5	1992	Thus, p97 may have a Zn-binding potential, unique amongst the transferrin superfamily.	Zinc	21-23	melanotransferrin	Homo sapiens	6-9
1815583-1	1991	The binding of Zn(II) ions to human and bovine alpha-lactalbumin has been studied by fluorescence, scanning microcalorimetry, and proteolytic digestion.	Zinc	15-21	lactalbumin alpha	Bos taurus	47-64
1822334-3	1991	It is suggested that interleukin-1 causes both changes by 1) increasing the metallothionein-mediated hepatic uptake to serum Zn and 2) upregulating ceruloplasmin (acute phase reactant) gene and synthesis in liver and subsequently the level of ceruloplasmin-Cu complexes in the blood.	Zinc	125-127	interleukin 1 alpha	Homo sapiens	21-34
1657160-11	1991	Displacement of Co2+ by 1 equiv of Zn2+, which binds tightly to the A site of the 3",5"-exonuclease, shifts the optical spectrum to 524 nm and lowers the extinction coefficient to 30 -1 cm-1, indicative of octahedral coordination.2+ the formation of the binuclear complex.	Zinc	35-39	complement C2	Homo sapiens	16-19
1770112-4	1991	PLC binds to the lecithin moiety in the presence of Zn2+ and is eluted with an acidic buffer containing EDTA.	Zinc	52-56	heparan sulfate proteoglycan 2	Homo sapiens	0-3
2116409-2	1990	The release of Zn2+ from transcription factor IIIA (TFIIIA) was examined with the metallochromic indicator 4-(2-pyridylazo)resorcinol (PAR) in the absence and presence of p-hydroxymercuriphenylsulfonate (PMPS).	Zinc	15-19	general transcription factor 3A L homeolog	Xenopus laevis	52-58
2116409-3	1990	With 0.5 mM PAR, approximately 5 eq of Zn2+ were released from TFIIIA, but no Zn2+ release was detected from the 7 S ribonucleoprotein.	Zinc	39-43	general transcription factor 3A L homeolog	Xenopus laevis	63-69
2116409-4	1990	The PMPS-promoted Zn2+ release from TFIIIA was 8.7 +/- 0.4 eq of Zn2+ of which approximately 4 eq of Zn2+ rebound to TFIIIA upon displacement of the mercurial with excess 2-mercaptoethanol.	Zinc	18-22	general transcription factor 3A L homeolog	Xenopus laevis	36-42
2116409-4	1990	The PMPS-promoted Zn2+ release from TFIIIA was 8.7 +/- 0.4 eq of Zn2+ of which approximately 4 eq of Zn2+ rebound to TFIIIA upon displacement of the mercurial with excess 2-mercaptoethanol.	Zinc	65-69	general transcription factor 3A L homeolog	Xenopus laevis	36-42
2116409-4	1990	The PMPS-promoted Zn2+ release from TFIIIA was 8.7 +/- 0.4 eq of Zn2+ of which approximately 4 eq of Zn2+ rebound to TFIIIA upon displacement of the mercurial with excess 2-mercaptoethanol.	Zinc	65-69	general transcription factor 3A L homeolog	Xenopus laevis	36-42
2116409-5	1990	These results suggest that at least two affinity classes of Zn2+ binding sites exist in TFIIIA, one of which is released to 0.5 mM PAR in the absence of PMPS.	Zinc	60-64	general transcription factor 3A L homeolog	Xenopus laevis	88-94
2116409-10	1990	This further indicates exposure of cysteine residues from Zn2+ binding domains in TFIIIA.	Zinc	58-62	general transcription factor 3A L homeolog	Xenopus laevis	82-88
2116409-14	1990	Thus, Zn2+ binding domains and all but 1 cysteine residue are buried in the 7 S particle, thereby facilitating site-specific labeling of TFIIIA.	Zinc	6-10	general transcription factor 3A L homeolog	Xenopus laevis	137-143
2187194-5	1990	Cd(II), Zn(II), Ag(I), Au(I), and Au(III) have been found to partially stimulate transcription in the presence of MerR, but concentrations at least two to three orders of magnitude greater than for Hg(II) are required.	Zinc	8-10	activator/repressor of mer operon	Escherichia coli	114-118
2310409-7	1990	These data suggest that CCl4-linked oxidation of MT, rather than the covalent binding of 14CCl4 metabolite(s), may be responsible for the CCl4-induced loss of metal binding sites of MT with the concurrent release of Zn and Cd.	Zinc	216-218	C-C motif chemokine ligand 4	Homo sapiens	24-28
33805849-1	2021	In this paper, the application of new substituted 2,6-bis((benzoyl-R)amino)pyridine (R = H, 4-Me, and 4-NMe2) derivatives for the recovery of copper(II), nickel(II), cobalt(II), and zinc(II) ions from aqueous solutions was described.	Zinc	182-190	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	104-108
34844338-5	2022	Results showed MC with molar ratio of Co and Zn at 3:1 (Co-CNT/NPC3/1) achieved the maximal adsorption capacity to 118.3 mg g-1.	Zinc	45-47	NPC intracellular cholesterol transporter 1	Homo sapiens	63-69
34599772-6	2022	Furthermore, the design of distributing bulk Zn in a 3D microscale manner suppresses hydrogen evolution reactions (3.8 mmol h-1 cm-2 ) and passivation through in/ex-situ tests.	Zinc	45-47	H1.5 linker histone, cluster member	Homo sapiens	124-132
34918920-1	2021	Tip-induced dendrites on metallic zinc anodes (MZAs) fundamentally deteriorate the rechargeability of aqueous Zn metal batteries (ZMBs).	Zinc	110-112	TOR signaling pathway regulator	Homo sapiens	0-3
34917771-9	2021	Because of their rare combination of concentrations above 100 mg/mL and high quantum yields, along with minimal self-absorption for good spatial resolution, Mn2+:CsPb(BrCl)3 NCs have the potential to displace ZnS:Cu as the leading scintillator for fast neutron imaging.	Zinc	209-212	granzyme B	Homo sapiens	162-166
34793676-0	2021	Morphology of Mixed Langmuir and Langmuir-Schaefer Monolayers with Covered CdSe/CdS/ZnS Quantum Dots and Arachidic Acid.	Zinc	84-87	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
34500246-1	2021	Based on the interesting Janus-type all-cis1,2,3,4,5,6-hexafluorocyclohexane (1) molecule, a novel type of excess electron compounds MF-1-MH (MF = Li, Na and K, MH = Zn, Cd and Hg) were designed theoretically.	Zinc	166-168	flap structure-specific endonuclease 1	Homo sapiens	133-137
34643326-5	2021	The energy storage mechanism of CNT@KMO@GC is clarified as H+ /Zn2+ coinsertion/extraction via electrochemical analysis and ex situ characterization.	Zinc	63-67	kynurenine 3-monooxygenase	Homo sapiens	36-39
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	integrin subunit alpha 10	Homo sapiens	147-163
34569575-0	2021	Thermodynamics and structural characterization of the nickel(II) and zinc(II) complexes of various peptide fragments of tau protein.	Zinc	69-77	microtubule associated protein tau	Homo sapiens	120-123
34569575-1	2021	Nickel(II) and zinc(II) complexes of various peptide fragments of tau protein have been investigated by potentiometric, UV-Vis, CD and ESI-MS techniques.	Zinc	15-23	microtubule associated protein tau	Homo sapiens	66-69
34569575-5	2021	The results of this study reveal that the histidyl residues of the N-terminal and R3 regions of tau protein can effectively bind nickel(II) and zinc(II) ions.	Zinc	144-152	microtubule associated protein tau	Homo sapiens	96-99
34712389-9	2021	Breeder plasma Zn concentration and erythrocytic 5"-NT activities at week 6 were positively correlated with GSH-Px activity and GPx, MT1, and BCL2 mRNA expressions in embryonic livers on E29.	Zinc	15-17	metallothionein 1I, pseudogene	Homo sapiens	133-136
34927952-1	2021	The imbalance of Zn2+ /Cd2+ in the human body can lead to many serious diseases due to the overuse of antibiotics and deposition in animal products.	Zinc	17-21	CD2 molecule	Homo sapiens	23-26
34927952-3	2021	Herein, silicon quantum dots (SiQDs) are designed as a functional platform for the detection of tetracycline and Zn2+ /Cd2+ .	Zinc	113-117	CD2 molecule	Homo sapiens	119-122
34927952-4	2021	The  COOH functionalized SiQDs with the emission wavelength of 450 nm are chelated with Eu(NO3 )3 to form SiQDs-Eu3+ ratio fluorescent probes, which can be used to detect tetracycline (TCs) and Zn2+ /Cd2+ by fluorescence resonance energy transfer (FRET) principle sequentially.	Zinc	194-198	CD2 molecule	Homo sapiens	200-203
34927952-6	2021	The detection limit of TCs and Zn2+ /Cd2+ are 0.2 x 10-6  m and 3 x 10-6  m, respectively, when the pH of the solution is 7.4.	Zinc	31-35	CD2 molecule	Homo sapiens	37-40
34551053-5	2021	In vitro cell culture using MC3T3-E1 preosteoblasts showed that the Zn2+ released from PEEK-AA-Zn promoted cell proliferation and elevated gene expression levels of alkaline phosphatase (ALP), osteocalcin (OCN) and bone sialoprotein (BSP).	Zinc	68-72	AT695_RS04080	Staphylococcus aureus	165-185
34551053-5	2021	In vitro cell culture using MC3T3-E1 preosteoblasts showed that the Zn2+ released from PEEK-AA-Zn promoted cell proliferation and elevated gene expression levels of alkaline phosphatase (ALP), osteocalcin (OCN) and bone sialoprotein (BSP).	Zinc	68-72	AT695_RS04080	Staphylococcus aureus	187-190
34390101-0	2021	Cyanides, Isocyanides, and Hydrides of Zn, Cd and Hg from Metal Atom and HCN Reactions: Matrix Infrared Spectra and Electronic Structure Calculations.	Zinc	39-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
34572390-8	2021	Here, we review the current understanding of the role of in Zn2+ the mammary gland, and the proteins controlling cellular Zn2+ homeostasis and signaling, including Zn2+ transporters and the Gq-coupled Zn2+ sensing receptor, ZnR/GPR39.	Zinc	201-205	G protein-coupled receptor 39	Homo sapiens	228-233
34414722-9	2021	PC1 (Cu, Zn, Cd, and Pb) metals mainly originate from industrial, agricultural, and traffic sources.	Zinc	9-11	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
34380651-5	2021	Expression of the Zn transporter ZIP8 is rapidly induced following bacterial infection and regulates myeloid cell function in a Zn-dependent manner.	Zinc	128-130	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	33-37
34380651-12	2021	These results (for the first time, to our knowledge) reveal a vital ZIP8- and Zn-mediated axis that alters the lung myeloid cell landscape and the host response against pneumococcus.	Zinc	78-80	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	68-72
34369509-4	2021	Typically, HDAC2 inhibitors interact with the Zn2+ ions through the core chelate group, while HDAC8 inhibitors adopt a bent conformation within the HDAC8 pocket that inclines to be in contact with the Zn2+ ions through the terminal hydroxamic acid group.	Zinc	201-205	histone deacetylase 8	Homo sapiens	94-99
34369509-4	2021	Typically, HDAC2 inhibitors interact with the Zn2+ ions through the core chelate group, while HDAC8 inhibitors adopt a bent conformation within the HDAC8 pocket that inclines to be in contact with the Zn2+ ions through the terminal hydroxamic acid group.	Zinc	201-205	histone deacetylase 8	Homo sapiens	148-153
34444090-5	2021	Significant positive correlations were found between maternal serum Se concentrations and zinc (Zn) and copper (Cu) in the total and regional cohorts.	Zinc	96-98	squalene epoxidase	Homo sapiens	68-70
34429849-0	2021	Nucleobindin-2 consists of two structural components: The Zn2+-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca2+-sensitive C-terminal half, consisting of nesfatin-3.	Zinc	58-62	nucleobindin 2	Homo sapiens	0-14
34429849-4	2021	At the N-terminal half, Nucb2 also possesses a putative Zn2+-binding motif.	Zinc	56-60	nucleobindin 2	Homo sapiens	24-29
34429849-8	2021	In contrast, Zn2+ binding had a more pronounced effect on the structure of Nucb2, leading to the local destabilization of its N-terminal half while also inducing changes within its C-terminal half.	Zinc	13-17	nucleobindin 2	Homo sapiens	75-80
34429849-10	2021	Taken together, the results of our previous and current research help to elucidate the structure of the Nucb2, which can be divided into two parts: the Zn2+-sensitive N-terminal half (consisting of nesfatin-1 and -2) and the Ca2+-sensitive C-terminal half (consisting of nesfatin-3).	Zinc	152-156	nucleobindin 2	Homo sapiens	104-109
34062038-4	2021	Mechanism studies indicate that the accompanying Zn 2+ generated from zinc reduction of the Co II complex plays a critical role to initiate a plausible Co I /Co III catalytic cycle.	Zinc	49-51	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	152-156
34361261-3	2021	The maximum adsorption capacity order of the heavy metals in the single system was Pb2+ > Cd2+ > Cu2+ > Zn2+, and this could be related to their hydration energy and electronegativity.	Zinc	104-108	CD2 molecule	Homo sapiens	90-93
34361261-5	2021	The selective adsorption capacities of the metals were in the order, Pb2+ > Cd2+   Cu2+ > Zn2+.	Zinc	90-94	CD2 molecule	Homo sapiens	76-79
34361202-0	2021	Magnetic and Highly Luminescent Heterostructures of Gd3+/ZnO Conjugated to GCIS/ZnS Quantum Dots for Multimodal Imaging.	Zinc	80-83	GRDX	Homo sapiens	52-55
34361202-2	2021	In this study, Gd3+/ZnO (ZnOGd) were conjugated with Qdots composed of a gadolinium-copper-indium-sulphur core covered with a ZnS shell (GCIS/ZnS Qdots).	Zinc	126-129	GRDX	Homo sapiens	15-18
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	RAD1 checkpoint DNA exonuclease	Homo sapiens	128-132
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	HUS1 checkpoint clamp component	Homo sapiens	133-137
34137399-2	2021	The MAF-7 functions as (i) the armour to preserve DNAzymes, (ii) an ATP scavenger to lower the intracellular ATP level, and (iii) a built-in Zn2+ arsenal to initiate the biocatalysis of DNAzymes, ultimately inhibiting P-gp expression to enhance chemotherapy.	Zinc	141-145	phosphoglycolate phosphatase	Homo sapiens	218-222
34203496-0	2021	Zn-Enhanced Asp-Rich Antimicrobial Peptides: N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides.	Zinc	0-2	assembly factor for spindle microtubules	Homo sapiens	12-15
34132526-1	2021	Herein, we propose the topotactic and self-templated fabrication of Zn1-xCdxSe porous nanobelt-ZnO nanorod (termed as ZnCdSe/ZnO) photoelectrode via the cadmium (Cd2+) ion-exchange process on zinc (Zn) foil.	Zinc	198-200	CD2 molecule	Homo sapiens	162-165
34068211-4	2021	It has been shown that MET plays a protective role against the toxic effects induced by different metals (Pb, Cd, Cu, Zn, B, Al, V, Ni, La, As, and Cr) by regulating both the enzymatic and non-enzymatic antioxidant plant defense systems.	Zinc	118-120	SAFB like transcription modulator	Homo sapiens	23-26
35460952-6	2022	RESULTS: In our study, the association with metabolic principal component (mPC) 1 (reflecting non-essential and essential amino acids, including branched chain, and bacterial co-metabolism versus fatty acids and VLDL subclasses) was positive for Se and Zn, but inverse for Cu, arsenobetaine-corrected arsenic (As) and Sb.	Zinc	253-255	mitochondrial pyruvate carrier 1	Homo sapiens	44-81
35460952-7	2022	The association with mPC2 (reflecting essential amino acids, including aromatic, and bacterial co-metabolism) was inverse for Se, Zn and Cd.	Zinc	130-132	minisatellite 6 hypermutable 3	Mus musculus	21-25
35626683-9	2022	Finally, we evaluated if Zn was able to attenuate the alterations of zonula occludens-1 (ZO-1), one of the tight-junction (TJ) proteins involved in the formation of the BBB.	Zinc	25-27	tight junction protein 1	Rattus norvegicus	69-87
35626683-9	2022	Finally, we evaluated if Zn was able to attenuate the alterations of zonula occludens-1 (ZO-1), one of the tight-junction (TJ) proteins involved in the formation of the BBB.	Zinc	25-27	tight junction protein 1	Rattus norvegicus	89-93
35626683-10	2022	Our data clearly demonstrate that Zn, by protecting from the SOD activity impairment induced by Cd, is able to prevent the triggering of the Cd-dependent signalling pathway that leads to ZO-1 dislocation and downregulation, and BBB damage.	Zinc	34-36	tight junction protein 1	Rattus norvegicus	187-191
35597015-6	2022	Contributed to the dissolution/deposition reaction mechanism combined with H+/Zn2+ co-insertion/co-extraction mechanism, it has achieved the high capacity with the maximum reversible specific capacity of 269.5 mAh g-1 at 0.5 A g-1 and excellent stability with 205.8 mAh g-1 even after 300 cycles in Zn//Al-KMO battery.	Zinc	78-82	kynurenine 3-monooxygenase	Homo sapiens	306-309
35503147-4	2022	In dyeing effluents, the average concentrations of Zn, Cu, Pb, Mn, Fe and Cr ions were 5.50, 82.75, 6.80, 14.27, 66.03 and 65.28 mug mL-1, respectively, while the amount of Cd was barely detectable.	Zinc	51-53	L1 cell adhesion molecule	Mus musculus	133-137
35486032-3	2022	The robust therapeutics of FEGCG/Zn are measured in terms of the regulating effect on programmed cell death ligand 1 (PD-L1), the effective delivery of diverse biomolecules, and the hitchhiking ability using living cells.	Zinc	33-35	CD274 molecule	Homo sapiens	86-116
35486032-3	2022	The robust therapeutics of FEGCG/Zn are measured in terms of the regulating effect on programmed cell death ligand 1 (PD-L1), the effective delivery of diverse biomolecules, and the hitchhiking ability using living cells.	Zinc	33-35	CD274 molecule	Homo sapiens	118-123
35486032-5	2022	Finally, the combination of FEGCG/Zn and siPD-L1 promotes antitumor immunotherapy through alleviation of T cells exhaustion by regulating PD-L1 expression in tumor cells.	Zinc	34-36	CD274 molecule	Homo sapiens	138-143
35169020-3	2022	Here, we show developmental regulation of the expression of Zn2+ transporters ZIP1 and ZIP3 in mouse hippocampal neurons, corresponding to previously described increase in neuronal vesicular Zn2+ during the first postnatal month.	Zinc	191-195	solute carrier family 39 (zinc transporter), member 1	Mus musculus	78-82
35169020-3	2022	Here, we show developmental regulation of the expression of Zn2+ transporters ZIP1 and ZIP3 in mouse hippocampal neurons, corresponding to previously described increase in neuronal vesicular Zn2+ during the first postnatal month.	Zinc	191-195	solute carrier family 39 (zinc transporter), member 3	Mus musculus	87-91
35169020-4	2022	Rates of Zn2+ uptake in cultured mouse hippocampal neurons, monitored using FluoZin-3 fluorescence, were higher in mature neurons, which express higher levels of ZIP1 and ZIP3.	Zinc	9-13	solute carrier family 39 (zinc transporter), member 1	Mus musculus	162-166
35169020-4	2022	Rates of Zn2+ uptake in cultured mouse hippocampal neurons, monitored using FluoZin-3 fluorescence, were higher in mature neurons, which express higher levels of ZIP1 and ZIP3.	Zinc	9-13	solute carrier family 39 (zinc transporter), member 3	Mus musculus	171-175
35169020-5	2022	Zn2+ uptake was attenuated by approximately 50% following silencing of either ZIP1 or ZIP3.	Zinc	0-4	solute carrier family 39 (zinc transporter), member 1	Mus musculus	78-82
35169020-5	2022	Zn2+ uptake was attenuated by approximately 50% following silencing of either ZIP1 or ZIP3.	Zinc	0-4	solute carrier family 39 (zinc transporter), member 3	Mus musculus	86-90
35169020-8	2022	Consistent with their localization, silencing of ZIP1 expression in vivo reduced Zn2+ uptake in CA3 neurons while ZIP3 silencing reduced Zn2+ influx into dentate gyrus granule cells in acute hippocampal slices.	Zinc	81-85	solute carrier family 39 (zinc transporter), member 1	Mus musculus	49-53
35169020-8	2022	Consistent with their localization, silencing of ZIP1 expression in vivo reduced Zn2+ uptake in CA3 neurons while ZIP3 silencing reduced Zn2+ influx into dentate gyrus granule cells in acute hippocampal slices.	Zinc	137-141	solute carrier family 39 (zinc transporter), member 3	Mus musculus	114-118
35069232-7	2021	Moreover, inhibition of STAT3 activation blocked zinc deficiency induced ZIP9 expression, and resulted in increased Zn2+ loss in cardiomyocytes, further confirming that STAT3 activation during reperfusion promotes the expression of ZIP9 zinc transporter to correct the imbalance in zinc homeostasis.	Zinc	116-120	signal transducer and activator of transcription 3	Rattus norvegicus	24-29
35069232-7	2021	Moreover, inhibition of STAT3 activation blocked zinc deficiency induced ZIP9 expression, and resulted in increased Zn2+ loss in cardiomyocytes, further confirming that STAT3 activation during reperfusion promotes the expression of ZIP9 zinc transporter to correct the imbalance in zinc homeostasis.	Zinc	116-120	signal transducer and activator of transcription 3	Rattus norvegicus	169-174
35071864-3	2022	More specifically, the end-of-waste from the thermal inertization of cement-asbestos and glass powder from domestic glass containers have been employed as sources for the hydrothermal synthesis of a tobermorite-rich material (TRM) successfully tested for the selective removal of Pb2+, Zn2+, Cd2+, and Ni2+ from aqueous solutions.	Zinc	286-290	CD2 molecule	Homo sapiens	292-295
2466831-11	1989	In contrast, the yield of "F" alpha 2M IL-1 beta complex formation was increased severalfold in the presence of 2.5 mM Zn2+.	Zinc	119-123	alpha-2-macroglobulin	Homo sapiens	30-38
2729929-2	1989	A 10-fold excess of either Zn2+ or Mn2+ partially antagonized inhibition of growth by Cd2+.	Zinc	27-31	CD2 molecule	Homo sapiens	86-89
2729929-8	1989	Increased Cd2+ in culture medium resulted in decreased Mn2+ and Zn2+ in cells of the susceptible strain but did not reduce the Mn2+ and Zn2+ content of cells of the tolerant strain.	Zinc	64-68	CD2 molecule	Homo sapiens	10-13
2841312-1	1988	Angiotensin-converting enzyme (ACE) is an Zn(II)-containing dipeptidyl carboxypeptidase that converts angiotensin I to the potent vasoconstrictor, angiotensin II.	Zinc	42-48	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	0-29
2841312-1	1988	Angiotensin-converting enzyme (ACE) is an Zn(II)-containing dipeptidyl carboxypeptidase that converts angiotensin I to the potent vasoconstrictor, angiotensin II.	Zinc	42-48	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	31-34
3185538-4	1988	alpha-Lactalbumin contains from 2 to 4 Cu2+ and Zn2+ binding sites, the number and affinities of which depend on Ca2+ concentration.	Zinc	48-52	lactalbumin alpha	Bos taurus	0-17
3185538-6	1988	The binding of Cu2+ and Zn2+ ions to parvalbumin and alpha-lactalbumin changes the shape and position of their thermal denaturation transitions.	Zinc	24-28	lactalbumin alpha	Bos taurus	53-70
2898949-2	1988	The C-2 histidyl regions of the 1H NMR spectra of insulin species containing respectively one Ca2+ and two Zn2+/hexamer and three Cd2+/hexamer have been assigned.	Zinc	107-111	complement C2	Homo sapiens	4-7
3683440-2	1987	Cd2+ was the most active followed by Cu2+, Hg2+, Zn2+ and Ag2.	Zinc	49-53	CD2 molecule	Homo sapiens	0-3
2827734-1	1987	Zn2+ in native glyoxalase I from human erythrocytes can be replaced by Cu2+, giving an inactive enzyme.	Zinc	0-4	glyoxalase I	Homo sapiens	15-27
2440383-1	1987	When alpha 2-macroglobulin (alpha 2M) is reacted with proteinases including trypsin, plasmin, alpha-thrombin, or with CH3NH2, each resulting alpha 2M derivative is precipitated by Zn2+ in a similar manner.	Zinc	180-184	alpha-2-macroglobulin	Homo sapiens	141-149
2440383-3	1987	Zn2+-induced precipitation of alpha 2M-CH3NH2 or alpha 2M-trypsin is prevented by acylation of the protein employing the histidine-specific reagent diethylpyrocarbonate (DEP).	Zinc	0-4	alpha-2-macroglobulin	Homo sapiens	30-38
2440383-3	1987	Zn2+-induced precipitation of alpha 2M-CH3NH2 or alpha 2M-trypsin is prevented by acylation of the protein employing the histidine-specific reagent diethylpyrocarbonate (DEP).	Zinc	0-4	alpha-2-macroglobulin	Homo sapiens	49-57
2440383-4	1987	The Zn2+-induced precipitation of alpha 2M-trypsin is prevented by acylation of the preformed alpha 2M-trypsin complex or by the reaction of acylated native alpha 2M with trypsin.	Zinc	4-8	alpha-2-macroglobulin	Homo sapiens	34-42
2440383-4	1987	The Zn2+-induced precipitation of alpha 2M-trypsin is prevented by acylation of the preformed alpha 2M-trypsin complex or by the reaction of acylated native alpha 2M with trypsin.	Zinc	4-8	alpha-2-macroglobulin	Homo sapiens	94-102
2440383-4	1987	The Zn2+-induced precipitation of alpha 2M-trypsin is prevented by acylation of the preformed alpha 2M-trypsin complex or by the reaction of acylated native alpha 2M with trypsin.	Zinc	4-8	alpha-2-macroglobulin	Homo sapiens	94-102
2440383-7	1987	These results indicate that histidyl residues are involved in the Zn2+-induced precipitation of alpha 2M-proteinase or alpha 2M-CH3NH2 complexes, and that these residues are accessible to extensive protein-metal interactions only after alpha 2M has undergone a major conformational change.	Zinc	66-70	alpha-2-macroglobulin	Homo sapiens	96-104
2440383-7	1987	These results indicate that histidyl residues are involved in the Zn2+-induced precipitation of alpha 2M-proteinase or alpha 2M-CH3NH2 complexes, and that these residues are accessible to extensive protein-metal interactions only after alpha 2M has undergone a major conformational change.	Zinc	66-70	alpha-2-macroglobulin	Homo sapiens	119-127
2440383-7	1987	These results indicate that histidyl residues are involved in the Zn2+-induced precipitation of alpha 2M-proteinase or alpha 2M-CH3NH2 complexes, and that these residues are accessible to extensive protein-metal interactions only after alpha 2M has undergone a major conformational change.	Zinc	66-70	alpha-2-macroglobulin	Homo sapiens	119-127
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	107-111	CD2 molecule	Homo sapiens	89-92
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	107-111	CD2 molecule	Homo sapiens	117-120
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	107-111	CD2 molecule	Homo sapiens	117-120
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	107-111	CD2 molecule	Homo sapiens	117-120
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	135-139	CD2 molecule	Homo sapiens	89-92
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	135-139	CD2 molecule	Homo sapiens	117-120
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	135-139	CD2 molecule	Homo sapiens	117-120
2959502-7	1987	For the 3-metal cluster, the affinity is found to decrease in the order Cu+ greater than Cd2+ greater than Zn2+ with Cd2+ greater than Zn2+ for the 4 metal cluster and Cd2+ (4-metal cluster) greater than Cd2+ (3-metal cluster).	Zinc	135-139	CD2 molecule	Homo sapiens	117-120
2959552-2	1987	In this study, we demonstrate a 1.7-fold increase in purified bovine liver delta-aminolevulinic acid dehydratase (ALAD) activity following incubation with purified kidney Zn-thionein isolated from Zn-treated rats.	Zinc	171-173	aminolevulinate dehydratase	Bos taurus	75-112
2959552-2	1987	In this study, we demonstrate a 1.7-fold increase in purified bovine liver delta-aminolevulinic acid dehydratase (ALAD) activity following incubation with purified kidney Zn-thionein isolated from Zn-treated rats.	Zinc	171-173	aminolevulinate dehydratase	Bos taurus	114-118
3958965-11	1986	Incubation of 65Zn-labeled PbBP fractions from brain and kidney with purified bovine liver ALAD demonstrated that the PbBPs donate Zn to ALAD.	Zinc	16-18	aminolevulinate dehydratase	Bos taurus	91-95
2423344-4	1986	The 22Na+ uptake experiments using veratridine or batrachotoxin to activate Na+ channels indicated that TTX-resistant Na+ channels are more sensitive to the inhibitory action of Cd2+ (IC50(Cd2+) = 0.2 mM) and of Zn2+ (IC50(Zn2+) = 50 microM) than TTX-sensitive Na+ channels (IC50(Cd2+) = 5 mM, IC50(Zn2+) = 2 mM).	Zinc	212-216	CD2 molecule	Homo sapiens	178-181
2423344-4	1986	The 22Na+ uptake experiments using veratridine or batrachotoxin to activate Na+ channels indicated that TTX-resistant Na+ channels are more sensitive to the inhibitory action of Cd2+ (IC50(Cd2+) = 0.2 mM) and of Zn2+ (IC50(Zn2+) = 50 microM) than TTX-sensitive Na+ channels (IC50(Cd2+) = 5 mM, IC50(Zn2+) = 2 mM).	Zinc	223-227	CD2 molecule	Homo sapiens	178-181
2423344-4	1986	The 22Na+ uptake experiments using veratridine or batrachotoxin to activate Na+ channels indicated that TTX-resistant Na+ channels are more sensitive to the inhibitory action of Cd2+ (IC50(Cd2+) = 0.2 mM) and of Zn2+ (IC50(Zn2+) = 50 microM) than TTX-sensitive Na+ channels (IC50(Cd2+) = 5 mM, IC50(Zn2+) = 2 mM).	Zinc	223-227	CD2 molecule	Homo sapiens	178-181
3754136-2	1986	In addition to Cd2+, the administration of Co2+ and other metal ions such as Se2+, Zn2+ and Cr2+ produced a significant increase of hepatic and/or renal ODC activity.	Zinc	83-87	ornithine decarboxylase 1	Rattus norvegicus	153-156
2959315-8	1986	In contrast, the results of functional assays of the T-lymphocyte response were dependent on the conditions of culture but suggested that the generation of IL-2 and its corresponding receptor were determined by the intracellular Zn status.	Zinc	229-231	interleukin 2	Rattus norvegicus	156-160
3931671-5	1985	From the difference in bis-ANS affinity between apo-alpha-LA and Ca(II)-alpha-LA, we demonstrated that Zn(II) and Al(III) were able to "lock" the protein into a new "apo-like" conformation, which was similar to, but not identical with, the apo conformation.	Zinc	103-109	lactalbumin alpha	Bos taurus	52-60
3931671-5	1985	From the difference in bis-ANS affinity between apo-alpha-LA and Ca(II)-alpha-LA, we demonstrated that Zn(II) and Al(III) were able to "lock" the protein into a new "apo-like" conformation, which was similar to, but not identical with, the apo conformation.	Zinc	103-109	lactalbumin alpha	Bos taurus	72-80
2982846-7	1985	In this process, the rate constant for spontaneous dissociation of Zn2+ from free enzyme is 1 X 10(-2) s-1 (t 1/2 = 1 min), which places a lower limit of 3 X 10(-10) M on the dissociation constant of Zn2+ at neutral pH from angiotensin-converting enzyme.	Zinc	67-71	angiotensin-converting enzyme	Oryctolagus cuniculus	224-253
6387045-3	1984	The formation constants for binding to the Co2+ and Cd2+ hybrids are of the order 10(6) M-1, which means that these hybrids have a 500-fold higher affinity for 2,2-dipyridyl than the native Zn2+ enzyme.	Zinc	190-194	CD2 molecule	Equus caballus	52-55
6583446-4	1984	The mean survival of rats beginning the Zn-deficient diet at T11 was significantly increased compared with that of the control group.	Zinc	40-42	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	61-64
6583446-6	1984	Similarly, excess Zn intake significantly prolonged the mean survival when given at T11.	Zinc	18-20	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	84-87
6660510-8	1983	The absorbance of the Zn2+-o-phenanthroline complex was about 10% that of the Co2+-o-phenanthroline complex at 346 nm, but was still sufficient to cause interference at Zn2+ concentrations above 10 microM.	Zinc	22-26	complement C2	Homo sapiens	78-81
6626166-4	1983	Evidence is presented that this reversal is largely an artifact, caused by the incorrect application of a control assay procedure and a spurious effect of Zn2+ (added in order to inhibit glutathione reductase) in crude enzyme solutions.	Zinc	155-159	glutathione-disulfide reductase	Rattus norvegicus	187-208
6407154-2	1983	The response to 13 metal ions has been examined, including several chemical groups from the periodic table: the IIb ions Zn2+, Cd2+, and Hg2+; the IIa ions, Be2+, Mg2+, Sr2+, and Ba2+; the transition elements, Ni2+, Cu2+, Co2+, and Mn2+: and trivalent ions, Y3+ and Cr3+.	Zinc	121-125	E(Mer)IIb	Drosophila melanogaster	112-115
7138835-2	1982	The apoenzyme of glyoxalase I (EC 4.4.1.5) from human erythrocytes was prepared by removal of Zn2+ with ethylenediaminetetraacetic acid (EDTA).	Zinc	94-98	glyoxalase I	Homo sapiens	17-29
6815104-5	1982	Divalent metals (Zn++, Cu++, Hg++, Co++, Cd++) were all efficient inhibitors of acrosin on the washed cells.	Zinc	17-21	acrosin	Homo sapiens	80-87
7317034-6	1981	The identity of the corresponding kinetic and binding parameters of the native enzyme and the Zn(2+)-re-activated apoenzyme and the clear differences from the parameters of the other metal-substituted enzyme forms give strong support to the previous identification of zinc as the natural metal cofactor of glyoxalase I.	Zinc	94-100	glyoxalase I	Homo sapiens	306-318
6167283-9	1981	It seems likely that albumin acts as the major transport protein for Zn in plasma of most species, Zn also being present firmly bound to alpha 2-macroglobulin.	Zinc	99-101	alpha-2-macroglobulin	Homo sapiens	137-158
7020752-10	1981	However, once the catalytic sites are filled, Cd2+ ions displace Mn2+ ions at the new sites as do Zn2+ ions.	Zinc	98-102	CD2 molecule	Equus caballus	46-49
7347132-3	1981	Kynureninase was also inhibited and inactivated by metal ions, especially Hg2+ and Zn2+.	Zinc	83-87	kynureninase	Rattus norvegicus	0-12
6257342-6	1980	In the presence of optimal levels of Co2+ other divalent cations are inhibitory with the order of inhibition: Cd2+ greater than Zn2+ greater than Ca2+ greater than Ba2+ greater than Cu2+ greater than Hg2+ greater than Ni2+.	Zinc	128-132	complement C2	Homo sapiens	37-40
6243635-8	1980	Both Zn2+ and Mg2+, as well as several other divalent cations, activate flavokinase, but Zn2+ yields greatest activity (1.8 times that with Mg2+).	Zinc	5-9	riboflavin kinase	Homo sapiens	72-83
7017904-2	1980	The elaboration of leucocyte migration inhibitory factor (LIF) by tuberculin-sensitized mononuclear cells stimulated with the specific antigen was reduced in a dose-dependent manner, an effect completely restored by addition of excess Zn2+.	Zinc	235-239	LIF interleukin 6 family cytokine	Homo sapiens	19-56
7017904-2	1980	The elaboration of leucocyte migration inhibitory factor (LIF) by tuberculin-sensitized mononuclear cells stimulated with the specific antigen was reduced in a dose-dependent manner, an effect completely restored by addition of excess Zn2+.	Zinc	235-239	LIF interleukin 6 family cytokine	Homo sapiens	58-61
647052-1	1978	The luminescene of 1O2 (1270 nm) has been observed upon illumination of air saturated solutions of different porphyrins and their complexes with Zn in CCl4.	Zinc	145-147	C-C motif chemokine ligand 4	Homo sapiens	151-155
4798313-2	1973	Inhibition by Zn(2+) of iron uptake by apoferritin at very low substrate concentrations is shown to be competitive.	Zinc	14-16	ferritin heavy chain 1	Homo sapiens	39-50
5503959-0	1970	[Effect of sodium bicarbonate, Mg2+, Mn2+ and Zn2+ on incorporation of C14 from radioactive acetate into proteins, lipids, liver glycogen and proteins of blood serum in chickens of different age].	Zinc	46-50	galectin 1A	Gallus gallus	71-74
33682282-8	2021	With a composition of Zn 3 (mIm) 5 (OH), ZIF-EC1 exhibits high N and Zn densities.	Zinc	22-24	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	45-48
33682282-8	2021	With a composition of Zn 3 (mIm) 5 (OH), ZIF-EC1 exhibits high N and Zn densities.	Zinc	69-71	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	45-48
34014775-9	2021	Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha.	Zinc	16-18	interleukin 1 alpha	Homo sapiens	86-94
33548652-3	2021	The presence of BLM and Fe2+ caused the formation of BLM-Fe (II) complex to cleave HP1, releasing DNAzyme fragments, which could further hybridize with substrate HP2 to form a partial double-stranded DNA duplex and enable the activation of Zn2+-dependent DNAzyme with the coexistence of Zn2+.	Zinc	240-244	chromobox 5	Homo sapiens	83-86
33548652-3	2021	The presence of BLM and Fe2+ caused the formation of BLM-Fe (II) complex to cleave HP1, releasing DNAzyme fragments, which could further hybridize with substrate HP2 to form a partial double-stranded DNA duplex and enable the activation of Zn2+-dependent DNAzyme with the coexistence of Zn2+.	Zinc	287-291	chromobox 5	Homo sapiens	83-86
33127139-4	2021	The results demonstrated that the addition of the BCP binder yielded remarkable increase in soil pH, unconfined compressive strength, and relative binding intensity index (IR) of target heavy metals including nickel (Ni) and zinc (Zn), while significantly decreased the electrical conductivity and leachability of contaminated soil.	Zinc	231-233	opsin 1, short wave sensitive	Homo sapiens	50-53
33515499-5	2021	LOD values were found as 0.025, 0.13 and 0.038 ng mL-1, respectively for Cr(III), Hg(II) and Zn(II).	Zinc	93-95	L1 cell adhesion molecule	Mus musculus	50-54
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Zinc	27-29	H1.5 linker histone, cluster member	Homo sapiens	74-82
33604973-5	2021	Encouragingly, a high-areal-capacity Zn@ZnF2 //MnO2 ( 3.2 mAh cm-2 ) full cell only produces maximum hydrogen flux of 0.06 mmol h-1 cm-2 (0.78% of the Zn//Zn cell) at the fully charging state.	Zinc	37-39	H1.5 linker histone, cluster member	Homo sapiens	128-136
33604973-5	2021	Encouragingly, a high-areal-capacity Zn@ZnF2 //MnO2 ( 3.2 mAh cm-2 ) full cell only produces maximum hydrogen flux of 0.06 mmol h-1 cm-2 (0.78% of the Zn//Zn cell) at the fully charging state.	Zinc	40-42	H1.5 linker histone, cluster member	Homo sapiens	128-136
33465674-2	2021	We find that Zn2+ activation of the Gq-coupled receptor ZnR/GPR39 controls these processes by regulating K+/Cl- co-transporter KCC3, which modulates cell volume.	Zinc	13-17	G protein-coupled receptor 39	Homo sapiens	60-65
33465674-5	2021	Immunofluorescence analysis indicates that Zn2+ activation of ZnR/GPR39 and KCC3 are required to enhance formation of F-actin stress fibers and cellular protrusions.	Zinc	43-47	G protein-coupled receptor 39	Homo sapiens	66-71
33443271-7	2021	The chemosensor coordinates with the Cd2+ and Zn2+ ions in different formation and coordination modes, leading to the emission position of the aggregates at 560 and 645 nm, respectively, based on which Cd2+ ions were successfully differentiated from Zn2+ ions.	Zinc	46-50	CD2 molecule	Homo sapiens	202-205
33443271-7	2021	The chemosensor coordinates with the Cd2+ and Zn2+ ions in different formation and coordination modes, leading to the emission position of the aggregates at 560 and 645 nm, respectively, based on which Cd2+ ions were successfully differentiated from Zn2+ ions.	Zinc	250-254	CD2 molecule	Homo sapiens	37-40
33443271-7	2021	The chemosensor coordinates with the Cd2+ and Zn2+ ions in different formation and coordination modes, leading to the emission position of the aggregates at 560 and 645 nm, respectively, based on which Cd2+ ions were successfully differentiated from Zn2+ ions.	Zinc	250-254	CD2 molecule	Homo sapiens	202-205
33443641-4	2021	The optimal activity of bee venom PLA2 was attained at pH 8 and 45  C. Cu2+, Ni2+, Fe2+, Ca2+, and Co2+ exhibited a complete activating effect on it, while Zn2+, Mn2+, NaN3, PMSF, N-Methylmaleimide, and EDTA have inhibitory effect.	Zinc	156-160	phospholipase A2	Apis mellifera	34-38
33320649-0	2021	Molecular Mechanisms and Aspects on the Role of Neuropeptide Y as a Zn2+ and Cu2+ Chelator.	Zinc	68-72	neuropeptide Y	Homo sapiens	48-62
33260324-4	2020	In this work, we have investigated Zn2+ binding to a short peptide 256-264 from C-terminus of RRM2 domain using isothermal titration calorimetry, electrospray ionization mass spectrometry, QM/MM simulations, and NMR spectroscopy.	Zinc	35-39	ribonucleotide reductase regulatory subunit M2	Homo sapiens	94-98
33260324-7	2020	Together with the existing structure of the RRM2 domain of TDP-43 we propose a model of its complex with Zn2+ which illustrates how zinc might regulate DNA/RNA binding.	Zinc	105-109	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-48
33255747-5	2020	Using immunoblotting, we show that specific inhibition of PP2A by okadaic acid (OA) alone leads to stoichiometric Syk S297 phosphorylation, as analyzed by Zn2+-Phos-tag gels, without affecting Syk Y-phosphorylation.	Zinc	155-159	protein phosphatase 2 phosphatase activator	Homo sapiens	58-62
33030499-0	2020	Zn2+ ions inhibit gene transcription following stimulation of the Ca2+ channels Cav1.2 and TRPM3.	Zinc	0-4	transient receptor potential cation channel subfamily M member 3	Homo sapiens	91-96
33030499-6	2020	We asked whether extracellular Zn2+ ions affect Cav1.2 or TRPM3-induced gene transcription following stimulation of the channels.	Zinc	31-35	transient receptor potential cation channel subfamily M member 3	Homo sapiens	58-63
33030499-7	2020	The results show that extracellular Zn2+ ions reduced the activation of AP-1 by more than 80% following stimulation of either voltage-gated Cav1.2 channels or TRPM3 channels.	Zinc	36-40	transient receptor potential cation channel subfamily M member 3	Homo sapiens	159-164
32454274-0	2020	Schiff base - Zn2+ ion combo as "pick and degrade" probe for selected organophosphorus chemical weapon mimics and flame retardant analog: Detoxification of fruits and vegetables in aqueous media.	Zinc	14-18	protein interacting with PRKCA 1	Homo sapiens	33-37
32488947-4	2020	Mononuclear species start to form around pH 6; Zn2+ binds both His18 and N-amino terminus in rat-IAPP(1-37; R18 H).	Zinc	47-51	islet amyloid polypeptide	Rattus norvegicus	97-101
32488947-5	2020	The in silico study allows us to assess not only a structured turn compact domain in r-IAPP(1-37) and r-IAPP(1-37; R18 H) featured by a different free energy barrier for the transition from the compact to elongated conformation upon the coordination of Zn2+ , but also to bring into light a coordination shell further stabilized by noncovalent interactions.	Zinc	253-257	islet amyloid polypeptide	Rattus norvegicus	87-91
32488947-5	2020	The in silico study allows us to assess not only a structured turn compact domain in r-IAPP(1-37) and r-IAPP(1-37; R18 H) featured by a different free energy barrier for the transition from the compact to elongated conformation upon the coordination of Zn2+ , but also to bring into light a coordination shell further stabilized by noncovalent interactions.	Zinc	253-257	islet amyloid polypeptide	Rattus norvegicus	104-108
33036976-6	2020	Injecting the Zn2+-coordinated gels decorated with leukemia inhibitory factor into injured mouse optic nerves led to prolonged cellular signaling and enhanced axon regeneration.	Zinc	14-18	leukemia inhibitory factor	Mus musculus	51-77
32445865-7	2020	Zn2+, whose transport systems translocate Cd2+, markedly enhanced the effects of Cd2+ on both the mitochondrial ROS levels and timing of neurotransmitter release.	Zinc	0-4	CD2 molecule	Homo sapiens	42-45
32445865-7	2020	Zn2+, whose transport systems translocate Cd2+, markedly enhanced the effects of Cd2+ on both the mitochondrial ROS levels and timing of neurotransmitter release.	Zinc	0-4	CD2 molecule	Homo sapiens	81-84
32445865-8	2020	Furthermore, in the presence of Zn2+ ions, Cd2+ also desynchronized the neurotransmitter release in the proximal region.	Zinc	32-36	CD2 molecule	Homo sapiens	43-46
32353602-6	2020	Zn was found to regulate the expression of peroxidases (peroxiredoxin-1, peroxiredoxin-5, peroxiredoxin-6) to relieve AFB1-induced oxidative stress.	Zinc	0-2	peroxiredoxin 1	Homo sapiens	56-71
32353602-6	2020	Zn was found to regulate the expression of peroxidases (peroxiredoxin-1, peroxiredoxin-5, peroxiredoxin-6) to relieve AFB1-induced oxidative stress.	Zinc	0-2	peroxiredoxin 5	Homo sapiens	73-88
32353602-7	2020	Moreover, Zn could decrease the expression of pro-apoptotic genes (cleaved-caspase-3, caspase-9, and Bax) and increase the expression of anti-apoptotic genes (Bcl-2 and Bcl-xl) to alleviate the cell apoptosis induced by AFB1.	Zinc	10-12	caspase 9	Homo sapiens	86-95
31968444-7	2020	The ultimate tensile strength (UTS) for Al-4 wt.% Zn- 2 wt.% Cu alloy was 121.67 MPa.	Zinc	50-52	G antigen 7	Homo sapiens	40-44
31951514-1	2020	The present work addresses the effect of excess levels of ZnCl2 and CuSO4 in the growth medium on the conjugative transfer of plasmids carrying the antibiotic resistance gene blaCMY-2 from extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.	Zinc	58-63	AmpC	Escherichia coli	175-183
32608795-3	2020	Heavy metal ions (Ni2+, Cd2+, Cu2+, and Zn2+) can reduce the removal efficiency of urea by mixed strains, and the degree of influence was Cd2+ > Cu2+ > Ni2+ > Zn2+.	Zinc	40-44	CD2 molecule	Homo sapiens	138-141
32608795-3	2020	Heavy metal ions (Ni2+, Cd2+, Cu2+, and Zn2+) can reduce the removal efficiency of urea by mixed strains, and the degree of influence was Cd2+ > Cu2+ > Ni2+ > Zn2+.	Zinc	159-163	CD2 molecule	Homo sapiens	24-27
32608795-3	2020	Heavy metal ions (Ni2+, Cd2+, Cu2+, and Zn2+) can reduce the removal efficiency of urea by mixed strains, and the degree of influence was Cd2+ > Cu2+ > Ni2+ > Zn2+.	Zinc	159-163	CD2 molecule	Homo sapiens	138-141
32677757-1	2020	Methionine (Met) cationized with Zn2+ , forming Zn (Met-H)+ (ACN) where ACN = acetonitrile, Zn (Met-H)+ , and ZnCl+ (Met), as well as Cd2+ , forming CdCl+ (Met), were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from the FELIX free electron laser.	Zinc	33-37	CD2 molecule	Homo sapiens	134-137
32354066-0	2020	Improvement of the Laser-Welded Lap Joint of Dissimilar Mg Alloy and Cu by Incorporation of a Zn Interlayer.	Zinc	94-96	LAP	Homo sapiens	32-35
32344527-5	2020	Adding Zn to the Al-4.6Mg alloy increased tensile strength and hardness, but decreased corrosion resistance.	Zinc	7-9	G antigen 7	Homo sapiens	17-21
32344527-6	2020	Combined, the addition of Mn and Zn to the Al-4.6Mg alloy exhibited the highest tensile strength and hardness, but seriously reduced corrosion resistance.	Zinc	33-35	G antigen 7	Homo sapiens	43-47
32211624-3	2020	HL1 selectively sensed Zn2+ ions, whereas HL2 detected Al3+ ions.	Zinc	23-27	intelectin 1	Homo sapiens	0-3
31927402-4	2020	And while the Electrospray ionization-mass spectrometry (ESI-MS) confirmed the complexation of Zn2+ and Fe2+ with both R1 and R4, there is no evidence for metalation of R1 or R4 with Fe3+.	Zinc	95-99	CD1b molecule	Homo sapiens	119-128
31909648-7	2020	In vivo study showed that CuInS2/ZnS QDs increased the levels of IL-4 on day 1 and enhanced the levels of IL-10 and IL-13 on day 28 in mice.	Zinc	33-36	interleukin 4	Mus musculus	65-69
31753647-0	2020	Rapid ratiometric detection of Cd2+ based on the formation of ZnSe/CdS quantum dots.	Zinc	62-66	CD2 molecule	Homo sapiens	31-34
31753647-2	2020	Here, we establish a simple, rapid and ratiometric strategy for the recognition of Cd2+ based on the formation of core-shell ZnSe/CdS structure using ZnSe quantum dots (QDs).	Zinc	125-129	CD2 molecule	Homo sapiens	83-86
31753647-2	2020	Here, we establish a simple, rapid and ratiometric strategy for the recognition of Cd2+ based on the formation of core-shell ZnSe/CdS structure using ZnSe quantum dots (QDs).	Zinc	150-154	CD2 molecule	Homo sapiens	83-86
31753647-4	2020	In the detection process, ZnSe QDs only possess absorption peak at 343 nm, the formation of ZnSe/CdS after the addition of Cd2+ leads to the appearance of the new peak at 397 nm, while other heavy metal ions could not cause the appearance of new absorption peak.	Zinc	26-30	CD2 molecule	Homo sapiens	123-126
31753647-4	2020	In the detection process, ZnSe QDs only possess absorption peak at 343 nm, the formation of ZnSe/CdS after the addition of Cd2+ leads to the appearance of the new peak at 397 nm, while other heavy metal ions could not cause the appearance of new absorption peak.	Zinc	92-96	CD2 molecule	Homo sapiens	123-126
31940246-6	2020	Zn chelator TPEN treatment reduced the expression of stem cell markers CD73, CD90 and CD105 and generated ROS in endometrial stromal cells.	Zinc	0-2	Thy-1 cell surface antigen	Homo sapiens	77-81
31802521-0	2020	The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway.	Zinc	42-45	mechanistic target of rapamycin kinase	Mus musculus	111-115
31802521-6	2020	We further demonstrated that the glycolytic shift from oxidative phosphorylation switching into aerobic glycolysis was required in the microglial activation into M1 phenotype induced by CdTe/ZnS QD treatment, which was mediated through the mTOR signaling pathway.	Zinc	191-194	mechanistic target of rapamycin kinase	Mus musculus	240-244
31829301-6	2020	In addition, Nano-ZnO could destroy neuronal structure by affecting cytoskeleton proteins (tubulin-alpha, tubulin-beta and NF-H), resulting in the interruption of connection between nerve cells, which lead to nervous system function damage.	Zinc	18-21	neurofilament heavy chain	Homo sapiens	123-127
31829301-7	2020	Meanwhile, Nano-ZnO could induce neuronal repair and regeneration disorders by affecting the growth-related protein GAP-43 and delayed neurotoxicity by affecting the calcium/calcium-regulated kinase (CAMK2A/CAMK2B protein) signaling pathway.	Zinc	16-19	growth associated protein 43	Homo sapiens	116-122
31670044-6	2020	The compound 1O responded to the metal ions (Cd2+/Zn2+) to form complexations with 1 : 1 stoichiometry which were verified by Job"s plot and MS analysis, respectively.	Zinc	50-54	CD2 molecule	Homo sapiens	45-48
31782883-2	2020	The quite close oxidation potential between neutral TTF and the coordination precursor, (HNEt3)2[M(pdms)2] (M = Co, Zn) causes multiple charge transfers (CTs) between SIM donor [M(pdms)2]n- and the TTF + acceptor as well as an intra-donor CT from the pdms ligand to Co ion upon electrocrystallization.	Zinc	116-118	ras homolog family member H	Homo sapiens	52-55
31782883-2	2020	The quite close oxidation potential between neutral TTF and the coordination precursor, (HNEt3)2[M(pdms)2] (M = Co, Zn) causes multiple charge transfers (CTs) between SIM donor [M(pdms)2]n- and the TTF + acceptor as well as an intra-donor CT from the pdms ligand to Co ion upon electrocrystallization.	Zinc	116-118	ras homolog family member H	Homo sapiens	198-201
32186269-0	2020	The influence of Ca2+ and Zn2+ on the amyloid fibril formation by beta-casein.	Zinc	26-30	casein beta	Homo sapiens	66-77
32186269-4	2020	OBJECTIVE: The effect of Ca2+ and Zn2+ on the amyloid fibril formation by beta-casein was investigated in the absence and presence of HS, which was significantly to explore the relationship between the concentration changes of Ca2+ and Zn2+ and amyloid fibril formation.	Zinc	34-38	casein beta	Homo sapiens	74-85
32186269-4	2020	OBJECTIVE: The effect of Ca2+ and Zn2+ on the amyloid fibril formation by beta-casein was investigated in the absence and presence of HS, which was significantly to explore the relationship between the concentration changes of Ca2+ and Zn2+ and amyloid fibril formation.	Zinc	236-240	casein beta	Homo sapiens	74-85
32186269-5	2020	METHOD: In this work, the influence of Ca2+ and Zn2+ on the beta-casein fibril formation in the absence and presence of HS was investigated by various methods of Thioflavin T fluorescence assay, transmission electron microscopy and intrinsic fluorescence measure.	Zinc	48-52	casein beta	Homo sapiens	60-71
32186269-6	2020	RESULTS: The results demonstrated that Ca2+ and Zn2+ promoted the beta-casein fibril formation.	Zinc	48-52	casein beta	Homo sapiens	66-77
32186269-9	2020	In addition, it was also observed that the microenvironment of beta-casein was changed because the intrinsic fluorescence peaks were red-shifted on the influence of Ca2+ and Zn2+.	Zinc	174-178	casein beta	Homo sapiens	63-74
32186269-10	2020	CONCLUSION: Ca2+ and Zn2+ were capable of promoting the beta-casein fibril formation in the both absence and presence of HS.	Zinc	21-25	casein beta	Homo sapiens	56-67
31905638-12	2019	The increase in HSP70 measured in fish exposed to 100 microg ZnS-QDs/L may be associated with high levels of Zn determined in fish tissues.	Zinc	61-64	heat shock protein 8-like	Danio rerio	16-21
31905638-12	2019	The increase in HSP70 measured in fish exposed to 100 microg ZnS-QDs/L may be associated with high levels of Zn determined in fish tissues.	Zinc	61-63	heat shock protein 8-like	Danio rerio	16-21
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	insulin-like growth factor I	Oryctolagus cuniculus	158-186
31842499-5	2019	Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p &lt; 0.01) growth rate, carcass yield (p &lt; 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p &lt; 0.05), as well as better jejunum morphometric variables (p &lt; 0.05).	Zinc	55-57	insulin-like growth factor I	Oryctolagus cuniculus	188-193
30783921-0	2019	Effect of the Zn Supplementation on Immuno-Modulatory Activities of Bovine Lactoferrin in the Murine Splenocytes and RAW264.7 Macrophages.	Zinc	14-16	lactotransferrin	Bos taurus	75-86
30783921-3	2019	Afterwards, bovine LF and the Zn-supplemented LF products at 10-40-mug/mL doses were compared for their immuno-modulatory activities in two immune cells (murine splenocytes and RAW264.7 macrophages), using the stimulation index of the splenocytes, T lymphocyte subpopulations, macrophage phagocytosis, and cytokine production as evaluation reflectors.	Zinc	30-32	lactotransferrin	Bos taurus	46-48
30783921-4	2019	The results showed that bovine LF and the Zn-supplemented LF products had suppressive effect on the splenocytes and concanavalin A (ConA)- and lipopolysaccharide-stimulated splenocytes, but lower Zn-saturation and lower dose could alleviate and even counteract this suppressive effect (P &lt; 0.05).	Zinc	42-44	lactotransferrin	Bos taurus	58-60
30783921-4	2019	The results showed that bovine LF and the Zn-supplemented LF products had suppressive effect on the splenocytes and concanavalin A (ConA)- and lipopolysaccharide-stimulated splenocytes, but lower Zn-saturation and lower dose could alleviate and even counteract this suppressive effect (P &lt; 0.05).	Zinc	196-198	lactotransferrin	Bos taurus	31-33
30783921-4	2019	The results showed that bovine LF and the Zn-supplemented LF products had suppressive effect on the splenocytes and concanavalin A (ConA)- and lipopolysaccharide-stimulated splenocytes, but lower Zn-saturation and lower dose could alleviate and even counteract this suppressive effect (P &lt; 0.05).	Zinc	196-198	lactotransferrin	Bos taurus	58-60
31628190-7	2019	To validate the bioinformatics and sequence kernel association test analyses, we functionally characterized rare missense and synonymous variants of GPR39, a family A GPCR, revealing altered expression or Zn2+-mediated signaling for members of both variant classes.	Zinc	205-209	G protein-coupled receptor 39	Homo sapiens	149-154
31783644-4	2019	We established that Tau binds 4 Zn2+ and 1 Ca2+ per monomer while using native mass spectrometry analysis, without inducing order or substantial conformational changes in the intrinsically disordered Tau, as determined by structural analysis using circular dichroism and Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopies.	Zinc	32-36	microtubule associated protein tau	Homo sapiens	20-23
31682760-3	2019	In this study, liquid chromatography-mass spectrometry (LC-MS) based metabolomics was used to reveal significantly altered metabolites and metabolic pathways in human bronchial epithelial cells exposed to four different types of MOx NPs (ZnO, SiO2, TiO2, and CeO2) at both high (25 mug/mL) and low (12.5 mug/mL) doses.	Zinc	238-241	monooxygenase DBH like 1	Homo sapiens	229-232
31720653-4	2019	Herein, we describe a new method for fabricating an NCF with vertically aligned ZnO NWs by inducing leaching-enabled capillary rise infiltration (LeCaRI) of uncross-linked and mobile oligomer chains from a poly(dimethylsiloxane) (PDMS) slab into the space between the vertically aligned ZnO NWs.	Zinc	80-83	neutrophil cytosolic factor 4	Homo sapiens	52-55
31720653-4	2019	Herein, we describe a new method for fabricating an NCF with vertically aligned ZnO NWs by inducing leaching-enabled capillary rise infiltration (LeCaRI) of uncross-linked and mobile oligomer chains from a poly(dimethylsiloxane) (PDMS) slab into the space between the vertically aligned ZnO NWs.	Zinc	287-290	neutrophil cytosolic factor 4	Homo sapiens	52-55
31675222-5	2019	(2)Zn2Cl4 undergoes macrocyclic ring inversion on the nuclear magnetic resonance (NMR) time scale with a free energy barrier DeltaG  of 15.5(3) kcal/mol at 295 K. In contrast, (2)Fe2Cl4 and (2)Co2Cl4 undergo slow ring inversion on the NMR chemical shift time scale at 295 K. The amine elimination reaction of 2" with Zr(NMe2)4 yields the bis-PDE complex (2"-4H)Zr2(NMe2)4, which was alkylated with AlMe3 and Al(CH2SiMe3)3 to generate (2"-4H)Zr2Me4 and (2"-4H)Zr2(CH2SiMe3)2(NMe2)2, respectively.	Zinc	3-9	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	320-324
31675222-5	2019	(2)Zn2Cl4 undergoes macrocyclic ring inversion on the nuclear magnetic resonance (NMR) time scale with a free energy barrier DeltaG  of 15.5(3) kcal/mol at 295 K. In contrast, (2)Fe2Cl4 and (2)Co2Cl4 undergo slow ring inversion on the NMR chemical shift time scale at 295 K. The amine elimination reaction of 2" with Zr(NMe2)4 yields the bis-PDE complex (2"-4H)Zr2(NMe2)4, which was alkylated with AlMe3 and Al(CH2SiMe3)3 to generate (2"-4H)Zr2Me4 and (2"-4H)Zr2(CH2SiMe3)2(NMe2)2, respectively.	Zinc	3-9	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	365-369
31675222-5	2019	(2)Zn2Cl4 undergoes macrocyclic ring inversion on the nuclear magnetic resonance (NMR) time scale with a free energy barrier DeltaG  of 15.5(3) kcal/mol at 295 K. In contrast, (2)Fe2Cl4 and (2)Co2Cl4 undergo slow ring inversion on the NMR chemical shift time scale at 295 K. The amine elimination reaction of 2" with Zr(NMe2)4 yields the bis-PDE complex (2"-4H)Zr2(NMe2)4, which was alkylated with AlMe3 and Al(CH2SiMe3)3 to generate (2"-4H)Zr2Me4 and (2"-4H)Zr2(CH2SiMe3)2(NMe2)2, respectively.	Zinc	3-9	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	365-369
31394511-3	2019	In this study, blue emitting ZnCdS/ZnS NCs with high quantum yield and stability are introduced to work with the yellow emission from CsPb(Br/I)3 perovskite NCs for WLEDs.	Zinc	35-38	granzyme B	Homo sapiens	134-138
31400593-7	2019	For biofilms, the MEF caused shifts in the bacterial community structures, and an EFI of 50 to 200 mV cm-1 significantly promoted the enrichment of Cu, Zn, Cd and Co by biofilms.	Zinc	152-154	E74 like ETS transcription factor 4	Homo sapiens	18-21
32039076-2	2019	Materials and Methods: The study was a before and after clinical trial conducted to evaluate the clinical efficacy of a desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals (Zn-CHA) for controlling DH.	Zinc	200-202	transcription factor like 5	Homo sapiens	203-206
32039076-3	2019	The trial involved 72 patients with DH who were evaluated four and eight weeks after using Zn-CHA toothpaste.	Zinc	91-93	transcription factor like 5	Homo sapiens	94-97
32039076-7	2019	Conclusion: The results suggested that the use of Zn-CHA nanocrystals dentifrice might become an effective therapy to reduce DH.	Zinc	50-52	transcription factor like 5	Homo sapiens	53-56
31586028-5	2019	Additionally, interaction with the caspase-7 exosite involves both the Zn3 and BRCT domains of PARP-1 and is mediated by RNA.	Zinc	71-74	caspase 7	Homo sapiens	35-44
31854831-9	2019	The primary source of Cd, Cr, and Ni was PC1, while PC2 was the main source of Pb and Zn.	Zinc	86-88	chromobox 4	Homo sapiens	52-55
31352117-10	2019	The expression level of CXC-chemokine, toll-like receptor 7 (TLR-7), immunoglobulin M heavy chain (IgM heavy chain) and interferon gamma (IFN-gamma) gene was upregulated in Zn-supplemented groups particularly in the nZnO30- supplemented group.	Zinc	173-175	toll-like receptor 8	Oreochromis niloticus	39-59
30552607-6	2019	The serum Se levels were positively correlated with serum zinc (Zn) in both IFG and IGT groups, while urinary Se were positively associated with urinary Zn and copper (Cu) in IGT group.	Zinc	64-66	squalene epoxidase	Homo sapiens	10-12
30552607-6	2019	The serum Se levels were positively correlated with serum zinc (Zn) in both IFG and IGT groups, while urinary Se were positively associated with urinary Zn and copper (Cu) in IGT group.	Zinc	153-155	squalene epoxidase	Homo sapiens	110-112
30552607-7	2019	The serum Se levels were positively correlated with serum Cu in both T1D and T2D groups, and urinary levels of Se were positively associated with serum zinc and urinary Cu, Zn, calcium (Ca), and magnesium (Mg) and negatively correlated with serum Ca and Mg in T2D group, while the urinary levels of Se were positively correlated with urinary Zn and Mg both in peripheral neuropathy (DPN) and retinopathy (DR) groups.	Zinc	173-175	squalene epoxidase	Homo sapiens	111-113
30552607-7	2019	The serum Se levels were positively correlated with serum Cu in both T1D and T2D groups, and urinary levels of Se were positively associated with serum zinc and urinary Cu, Zn, calcium (Ca), and magnesium (Mg) and negatively correlated with serum Ca and Mg in T2D group, while the urinary levels of Se were positively correlated with urinary Zn and Mg both in peripheral neuropathy (DPN) and retinopathy (DR) groups.	Zinc	173-175	squalene epoxidase	Homo sapiens	111-113
31236859-9	2019	Moreover, as  tox increases, it indicates an increase in the concentration of eleven (Ca, P, Co, Cr, Fe, I, Mn, Li, Ni, V, As) and a decrease of two elements in hair (B, Si); for six elements (K, Mg, Na, Cu, Zn, Sn), such a connection was not revealed.	Zinc	208-210	thymocyte selection associated high mobility group box	Equus caballus	14-17
31384878-7	2019	In the whole study population after the completion of the intervention hair Zn correlated positively with serum HEPC and FAM and negatively with serum FE.	Zinc	76-78	hepcidin antimicrobial peptide	Homo sapiens	112-116
30613975-4	2019	Furthermore, the increased [Zn2+ ]i induced a significant increase in messenger RNA (mRNA) level of beta3 -AR in cardiomyocytes.	Zinc	28-32	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	100-105
30613975-9	2019	Overall, our present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn2+ ]i pathways.	Zinc	229-233	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	76-81
31171812-6	2019	Platelets from Nbeal2-/- mice mimicking Gray platelet syndrome (GPS), characterized by primarily loss of the alpha-granule content, had strongly reduced Zn2+ levels, which was also confirmed in primary megakaryocytes.	Zinc	153-157	neurobeachin-like 2	Mus musculus	15-21
31171812-8	2019	In turbidity and flow based assays, platelet-dependent fibrin formation was impaired in both Nbeal2-/- and Unc13d-/- mice, and the impairment could be partially restored by extracellular Zn2+.	Zinc	187-191	neurobeachin-like 2	Mus musculus	93-99
31006963-1	2019	BACKGROUND: The catalytic domain of ADAMTS13 possesses one Zn2+ and up to three putative Ca2+ binding sites and can be inactivated by chelating agents.	Zinc	59-63	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	36-44
30747203-10	2019	Moreover, compound 1 could be established as a selective and efficient sensor of Zn2+ in aqueous solution even in the presence of Cd2+ and other metal ions.	Zinc	81-85	CD2 molecule	Homo sapiens	130-133
30942077-8	2019	Twenty muM Zn supplement dramatically enhanced MTs and MTF-1 levels in Cd-exposed RAW 264.7 macrophages.	Zinc	11-13	metal response element binding transcription factor 1	Mus musculus	55-60
30942077-9	2019	Intracellular Zn2+ chelation or MTF-1 gene silencing inhibited MTs synthesis in Cd-exposed RAW 264.7 macrophages, which was accompanied by the declined expression of MTF-1, indicating that regulation of Zn on MTs was partially achieved by MTF-1 mobilization.	Zinc	14-18	metal response element binding transcription factor 1	Mus musculus	166-171
30942077-9	2019	Intracellular Zn2+ chelation or MTF-1 gene silencing inhibited MTs synthesis in Cd-exposed RAW 264.7 macrophages, which was accompanied by the declined expression of MTF-1, indicating that regulation of Zn on MTs was partially achieved by MTF-1 mobilization.	Zinc	14-18	metal response element binding transcription factor 1	Mus musculus	166-171
30942077-9	2019	Intracellular Zn2+ chelation or MTF-1 gene silencing inhibited MTs synthesis in Cd-exposed RAW 264.7 macrophages, which was accompanied by the declined expression of MTF-1, indicating that regulation of Zn on MTs was partially achieved by MTF-1 mobilization.	Zinc	14-16	metal response element binding transcription factor 1	Mus musculus	166-171
30942077-9	2019	Intracellular Zn2+ chelation or MTF-1 gene silencing inhibited MTs synthesis in Cd-exposed RAW 264.7 macrophages, which was accompanied by the declined expression of MTF-1, indicating that regulation of Zn on MTs was partially achieved by MTF-1 mobilization.	Zinc	14-16	metal response element binding transcription factor 1	Mus musculus	166-171
30803063-4	2019	Furthermore, wearable Zn-air battery based on Co SA@NCF/CNF air electrode displays superior stability under deformation, satisfactory energy storage capacity, and good practicality to be utilized as an integrated battery system.	Zinc	22-24	neutrophil cytosolic factor 4	Homo sapiens	52-55
30892024-1	2019	Novel hetero-binuclear platinum complexes (HBC-Pt(II)-M(II), M = Ca(II), Mg(II), Zn(II), and Cd(II)) have been synthesized by the reaction of the corresponding precursors [Pt(ppy)(mu-Cl)]2 with (2-(1 H-tetrazol-5-yl)phenyl)diphenylphosphine oxide (TTPPO).	Zinc	81-87	keratin 88, pseudogene	Homo sapiens	43-46
29716435-5	2019	Physiological micromolar Zn2+ stimulated ANXA5 transcription, raising ANXA5 protein expression and surface abundance on BeWo and human umbilical vein endothelial cells (HUVEC), thus resulting in prolonged coagulation times.	Zinc	25-29	annexin A5	Homo sapiens	41-46
29716435-5	2019	Physiological micromolar Zn2+ stimulated ANXA5 transcription, raising ANXA5 protein expression and surface abundance on BeWo and human umbilical vein endothelial cells (HUVEC), thus resulting in prolonged coagulation times.	Zinc	25-29	annexin A5	Homo sapiens	70-75
30700571-7	2019	The Zn2+-induced conformational change was required for the formation of GAPR-1 oligomers and amyloid-like assemblies in the presence of heparin, as shown by ThT fluorescence and TEM.	Zinc	4-8	GLI pathogenesis related 2	Homo sapiens	73-79
30723194-2	2019	Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone ERp44, modulating its localization and ability to retrieve clients like Ero1alpha and ERAP1 to the endoplasmic reticulum (ER).	Zinc	19-23	endoplasmic reticulum aminopeptidase 1	Homo sapiens	165-170
30723194-3	2019	Silencing the Zn2+ transporters that uptake Zn2+ into the Golgi led to ERp44 dysfunction and increased secretion of Ero1alpha and ERAP1.	Zinc	14-18	endoplasmic reticulum aminopeptidase 1	Homo sapiens	130-135
30500420-8	2019	Allicin stimulated the immune response by causing Zn2+ release from proteins and increasing the Zn2+-dependent IL-1-triggered production of IL-2 in murine EL-4 T-cells.	Zinc	96-100	interleukin 2	Mus musculus	140-144
30602243-6	2019	The selectivity study in bimetal aqueous systems using copper, lead and zinc metals showed the adsorption order of Cu2+ &gt; Cd2+ &gt; Zn2+ &gt; Pb2+.	Zinc	135-139	CD2 molecule	Homo sapiens	125-128
29948940-0	2019	Rapid Intracellular Zn2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP.	Zinc	20-24	carbonic anhydrase 1	Rattus norvegicus	103-106
29948940-3	2019	In anesthetized rats, extracellular Zn2+ level was increased under local perfusion of the hippocampal CA1 with 500 ng/ml corticosterone.	Zinc	36-40	carbonic anhydrase 1	Rattus norvegicus	102-105
30076580-0	2019	Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism.	Zinc	104-106	hematopoietic prostaglandin D synthase	Rattus norvegicus	14-39
30076580-0	2019	Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism.	Zinc	104-106	mitogen-activated protein kinase 8	Rattus norvegicus	52-75
30076580-3	2019	The study aimed to explore the role of GST-pi in Zn-induced Parkinsonism and its underlying molecular mechanism.	Zinc	49-51	hematopoietic prostaglandin D synthase	Rattus norvegicus	39-42
30076580-9	2019	The results demonstrate that Zn inhibits GST-pi expression leading to increased oxidative stress and JNK activation, which induce apoptosis thereby degeneration of the nigrostriatal dopaminergic neurons.	Zinc	29-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	41-44
30076580-9	2019	The results demonstrate that Zn inhibits GST-pi expression leading to increased oxidative stress and JNK activation, which induce apoptosis thereby degeneration of the nigrostriatal dopaminergic neurons.	Zinc	29-31	mitogen-activated protein kinase 8	Rattus norvegicus	101-104
30687374-9	2018	Moreover, the present study provides new insights into the coordinated function of NtZIP1, NtZIP2, NtZIP4, NtZIP5, NtZIP8, NtIRT1, and NtIRT1-like in response to low-to-high Zn status.	Zinc	174-176	probable zinc transporter 10	Nicotiana tabacum	135-141
30298533-6	2019	Transepithelial electrical resistance of distal small intestinal mucosa was higher for pigs fed the alternative ZnO source as compared with groups fed 110 mg/kg Zn of conventional ZnO, in line with a trend for higher gene expression of claudin-1 and zona occludens-1.	Zinc	112-114	claudin 1	Sus scrofa	236-266
30342059-1	2019	ZIP8 is a membrane transporter that facilitates the uptake of divalent metals (e.g., Zn, Mn, Fe, Cd) and the mineral selenite in anionic form.	Zinc	85-87	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-4
30575723-4	2018	Together with computational studies, the structure reveals that ACER3 is an intramembrane enzyme with a seven transmembrane domain architecture and a catalytic Zn2+ binding site in its core, similar to adiponectin receptors.	Zinc	160-164	alkaline ceramidase 3	Homo sapiens	64-69
30575723-5	2018	Interestingly, we uncover a Ca2+ binding site physically and functionally connected to the Zn2+ providing a structural explanation for the known regulatory role of Ca2+ on ACER3 enzymatic activity and for the loss of function in E33G-ACER3 mutant found in leukodystrophic patients.	Zinc	91-95	alkaline ceramidase 3	Homo sapiens	172-177
30575723-5	2018	Interestingly, we uncover a Ca2+ binding site physically and functionally connected to the Zn2+ providing a structural explanation for the known regulatory role of Ca2+ on ACER3 enzymatic activity and for the loss of function in E33G-ACER3 mutant found in leukodystrophic patients.	Zinc	91-95	alkaline ceramidase 3	Homo sapiens	234-239
30532259-7	2018	The crystal structure of the HDAC3:SMRT complex possesses two monovalent cations (MVCs) labeled as potassium with one MVC binding site near the active site Zn(II) and the second MVC binding site &gt;=20 A from the active site Zn(II).	Zinc	156-158	histone deacetylase 3	Apis mellifera	29-34
30532259-7	2018	The crystal structure of the HDAC3:SMRT complex possesses two monovalent cations (MVCs) labeled as potassium with one MVC binding site near the active site Zn(II) and the second MVC binding site &gt;=20 A from the active site Zn(II).	Zinc	226-228	histone deacetylase 3	Apis mellifera	29-34
30532259-8	2018	We report here the inhibitory effects of excess Zn(II) on the catalytic activity of histone deacetylase 3 (HDAC3) bound to the deacetylase activating domain of nuclear receptor corepressor 2 (NCOR2).	Zinc	48-50	histone deacetylase 3	Apis mellifera	84-105
30532259-8	2018	We report here the inhibitory effects of excess Zn(II) on the catalytic activity of histone deacetylase 3 (HDAC3) bound to the deacetylase activating domain of nuclear receptor corepressor 2 (NCOR2).	Zinc	48-50	histone deacetylase 3	Apis mellifera	107-112
30187212-7	2018	These results suggest that the high net negative charge of the glutamic acid-rich region of prothymosin-alpha is not a sufficient criterion for Zn2+ to induce a structural change; rather, Zn2+ binding to prothymosin-alpha is sequence specific, providing important insight into the behavior of intrinsically disordered proteins.	Zinc	188-192	prothymosin alpha pseudogene 9	Homo sapiens	204-221
30485271-1	2018	The role of zinc (Zn2+), a modulator of N-methyl-D-aspartate (NMDA) receptors, in regulating long-term synaptic plasticity at hippocampal CA1 synapses is poorly understood.	Zinc	18-22	carbonic anhydrase 1	Mus musculus	138-141
30485271-3	2018	Low micromolar concentrations of exogenous Zn2+ enhanced the induction of LTP, and this effect required activation of NMDA receptors containing NR2B subunits.	Zinc	43-47	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	144-148
30485271-4	2018	Zn2+ elicited a selective increase in NMDA/NR2B fEPSPs, and removal of endogenous Zn2+ with high-affinity Zn2+ chelators robustly reduced the magnitude of stimulus-evoked LTP.	Zinc	0-4	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	43-47
30485271-5	2018	Taken together, our data show that Zn2+ at physiological concentrations enhances activation of NMDA receptors containing NR2B subunits, and that this effect enhances the magnitude of LTP.	Zinc	35-39	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	121-125
30257870-4	2018	We map the interaction to the highly conserved Zn2+-binding N-terminal (AZUL) domain of UBE3A, the integrity of which is crucial for binding to PSMD4.	Zinc	47-51	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	144-149
30482150-1	2018	The structure and function of a 27-a.a. fragment of the N-terminal sequence of human endostatin (ES-Zn) were compared to those of the mutant peptide (ES-SSZn) obtained by adding Cys-Pro-Ala to the endostatin N-terminus and substituting Asn16 for Cys ensuring formation of a disulfide bond.	Zinc	100-102	collagen type XVIII alpha 1 chain	Homo sapiens	85-95
30150315-0	2018	Systemic Upregulation of MTP2- and HMA2-Mediated Zn Partitioning to the Shoot Supplements Local Zn Deficiency Responses.	Zinc	49-51	heavy metal atpase 2	Arabidopsis thaliana	35-39
30150315-3	2018	Physiological Zn deficiency of Arabidopsis thaliana shoots results in increased root transcript levels of the membrane transport protein-encoding genes METAL TRANSPORT PROTEIN2 (MTP2) and HEAVY METAL ATPASE2 (HMA2), which are unresponsive to the local Zn status of roots.	Zinc	14-16	heavy metal atpase 2	Arabidopsis thaliana	188-207
30150315-3	2018	Physiological Zn deficiency of Arabidopsis thaliana shoots results in increased root transcript levels of the membrane transport protein-encoding genes METAL TRANSPORT PROTEIN2 (MTP2) and HEAVY METAL ATPASE2 (HMA2), which are unresponsive to the local Zn status of roots.	Zinc	14-16	heavy metal atpase 2	Arabidopsis thaliana	209-213
30150315-4	2018	MTP2 and HMA2 act additively in the partitioning of Zn from roots to shoots.	Zinc	52-54	heavy metal atpase 2	Arabidopsis thaliana	9-13
30015240-4	2018	Although the overexpression of ZIP8 increased the absorption of Zn2+, Fe2+ and Cd2+ in monocytes, only Zn2+ supplementation was demonstrated capable of promoting the adhesion of monocytes to endothelial monolayers in vitro.	Zinc	64-68	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	31-35
30015240-5	2018	In addition, we confirmed the role of ZIP8-dependent Zn2+ influx in promoting monocyte adhesion to the aortas ex-vivo.	Zinc	53-57	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	38-42
30015240-7	2018	Overall, our results suggest that the Zn2+ influx in monocytes regulated by ZIP8 is a novel factor determining their adhesion and recruitment to atherosclerotic lesions, and that targeting ZIP8 or Zn2+ homeostasis may represent a novel strategy to interfere these activities.	Zinc	38-42	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	76-80
30015240-7	2018	Overall, our results suggest that the Zn2+ influx in monocytes regulated by ZIP8 is a novel factor determining their adhesion and recruitment to atherosclerotic lesions, and that targeting ZIP8 or Zn2+ homeostasis may represent a novel strategy to interfere these activities.	Zinc	38-41	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	76-80
30142952-5	2018	Based on the preferential localization of HPRG at the sarcomeric I-band and on the presence of a Zn2+ binding motif in the N-terminal regions of fast TnT and of the AMPD1 catalytic subunit, we advance the hypothesis that the Zn binding properties of HPRG could promote the association of AMPD1 to the thin filament.	Zinc	97-101	troponin T1, slow skeletal type	Homo sapiens	150-153
30142952-5	2018	Based on the preferential localization of HPRG at the sarcomeric I-band and on the presence of a Zn2+ binding motif in the N-terminal regions of fast TnT and of the AMPD1 catalytic subunit, we advance the hypothesis that the Zn binding properties of HPRG could promote the association of AMPD1 to the thin filament.	Zinc	97-99	troponin T1, slow skeletal type	Homo sapiens	150-153
29912548-5	2018	With these sensors, we showed that upon exposure to high Zn2+, only the cytosol and the IMS were overloaded with Zn2+, while the mitochondrial matrix was unable to sequester excess labile Zn2+ in depolarized INS-1 cells.	Zinc	57-61	insulin 1	Rattus norvegicus	208-213
30013175-1	2018	Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+, Mn2+ and Fe2+.	Zinc	172-176	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	0-7
30013175-1	2018	Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+, Mn2+ and Fe2+.	Zinc	172-176	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	16-20
30013175-1	2018	Slc39a8 encodes ZIP8, a divalent cation/bicarbonate symporter expressed in pluripotent mouse embryonic stem cells, and therefore ubiquitous in adult tissues; ZIP8 influxes Zn2+, Mn2+ and Fe2+.	Zinc	172-176	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	158-162
30112002-2	2018	When the metal ions were extracted from an aqueous ammonia solution, the metal ion selectivity for extraction was found to decrease in the order Cd2+&gt; Ni2+&gt; Cu2+&gt; Ag+&gt; Co2+&gt; Zn2+.	Zinc	189-193	complement C2	Homo sapiens	180-183
29248756-1	2018	The concentration and distribution of Mg, P, Cl, K, Cu and Zn in the dorsal hippocampus CA1 region of rat brains were studied during memory consolidation and reconsolidation processes stimulated with inhibitory avoidance (IA) tests.	Zinc	59-61	carbonic anhydrase 1	Rattus norvegicus	88-91
29950603-8	2018	The CQ-driven perturbation of brain Zn2+ was found to reduce levels of BDNF, synaptic plasticity-related proteins and dendritic spine density in vivo.	Zinc	36-40	brain derived neurotrophic factor	Mus musculus	71-75
29890674-1	2018	Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases.	Zinc	33-37	hedgehog	Drosophila melanogaster	6-14
29965645-7	2018	The levels of As, Cd, Cr, Cu, Ni, Pb, and Zn were dominated by human activities and the parent soil material (PC1).	Zinc	42-44	polycystin 1, transient receptor potential channel interacting	Homo sapiens	110-113
29750435-6	2018	Zn2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A-tyrosine kinase Src (Src)-epidermal growth factor receptor and phospholipase C. Both the transmembrane AC and the soluble-AC are involved in the stimulation of HAM by Zn2+ .	Zinc	0-4	G protein-coupled receptor 39	Homo sapiens	90-95
29750435-6	2018	Zn2+ at micromolar concentration stimulates HAM, which is mediated by a cascade involving GPR39-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A-tyrosine kinase Src (Src)-epidermal growth factor receptor and phospholipase C. Both the transmembrane AC and the soluble-AC are involved in the stimulation of HAM by Zn2+ .	Zinc	320-324	G protein-coupled receptor 39	Homo sapiens	90-95
29750435-10	2018	These data support a role for extracellular Zn2+ acting via GPR39 to regulate signaling pathways in sperm capacitation, leading to HAM induction.	Zinc	44-48	G protein-coupled receptor 39	Homo sapiens	60-65
29501129-2	2018	For the first time, core/shell CdSe/ZnS quantum dots were conjugated with anti-HE4 IgG antibodies for subsequent sandwich-type immunosensing with superparamagnetic microparticles functionalized with anti-HE4 IgG antibodies, which allow rapid and efficient HE4 capture from the sample.	Zinc	36-39	WAP four-disulfide core domain 2	Homo sapiens	79-82
29501129-2	2018	For the first time, core/shell CdSe/ZnS quantum dots were conjugated with anti-HE4 IgG antibodies for subsequent sandwich-type immunosensing with superparamagnetic microparticles functionalized with anti-HE4 IgG antibodies, which allow rapid and efficient HE4 capture from the sample.	Zinc	36-39	WAP four-disulfide core domain 2	Homo sapiens	204-207
29501129-2	2018	For the first time, core/shell CdSe/ZnS quantum dots were conjugated with anti-HE4 IgG antibodies for subsequent sandwich-type immunosensing with superparamagnetic microparticles functionalized with anti-HE4 IgG antibodies, which allow rapid and efficient HE4 capture from the sample.	Zinc	36-39	WAP four-disulfide core domain 2	Homo sapiens	204-207
29344880-7	2018	In an experimental model of organic crystal formation produced by silencing xanthine dehydrogenase in Drosophila fly, maneuvers that reduce Zn excretion have shown to reduce crystal formation in the lumen of the Malpighian tubules.	Zinc	140-142	rosy	Drosophila melanogaster	76-98
29503991-1	2018	An easy to prepare novel vitamin B6 cofactor derivative 3-hydroxy-N"-((3 hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)-2-naphthohydrazide (NPY) was synthesized by a one pot condensation reaction of pyridoxal with 3-hydroxy-2-naphthoic hydrazide and applied for the optical detection of Zn2+ and cysteine in the aqueous DMSO medium.	Zinc	298-302	neuropeptide Y	Homo sapiens	151-154
29503991-2	2018	The addition of Zn2+ ions leads to a selective blue-shift in the fluorescence emission spectrum of NPY from 530 nm to 475 nm, which allowed ratiometric detection of Zn2+ ions down to 8.73 x 10-7 M without any interference from other tested metal ions.	Zinc	16-20	neuropeptide Y	Homo sapiens	99-102
29503991-2	2018	The addition of Zn2+ ions leads to a selective blue-shift in the fluorescence emission spectrum of NPY from 530 nm to 475 nm, which allowed ratiometric detection of Zn2+ ions down to 8.73 x 10-7 M without any interference from other tested metal ions.	Zinc	165-169	neuropeptide Y	Homo sapiens	99-102
29503991-4	2018	Further, when the in situ generated NPY Zn2+ complex was interacted with various amino acids, the addition of cysteine resulted in an instantaneous colour change from light yellow to colourless and the absorbance at 435 nm of the complex was quenched selectively.	Zinc	40-44	neuropeptide Y	Homo sapiens	36-39
29503991-5	2018	Also, the fluorescence of the NPY Zn2+ complex was quenched, which allowed the detection of cysteine down to 6.63 x 10-7 M.	Zinc	34-38	neuropeptide Y	Homo sapiens	30-33
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	heme oxygenase 1	Homo sapiens	63-79
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	selectin L	Homo sapiens	81-91
29351417-10	2018	In sum, extracellular Zn2+ regulates endothelial cell activity in a ZnR/GPR39-dependent manner and through the downstream Galphaq-PLC pathways.	Zinc	22-26	G protein-coupled receptor 39	Homo sapiens	72-77
29224046-7	2018	Median Cr and Zn concentrations in the Leyole river in the effluent mixing zones downstream of the tannery and steel processing plant increased by factors of 52 (2660 compared with 51 microg Cr/L) and 5 (520 compared with 110 microg Zn/L), respectively, compared with stations further upstream.	Zinc	14-16	interleukin 31 receptor A	Homo sapiens	191-202
29596360-2	2018	Sensor H4L could show fluorescence turn-on response rapidly and significant selectivity to Cd2+ over many other metallic ions (Cu2+, Ba2+, Ca2+, K+, Cr3+, Mn2+, Sr2+, Co2+, Na+, Li+, Ni2+, Ag+, and Zn2+), and a clear change in color from colorless to yellow that can be very easily observed via the naked eyes in the existence of Cd2+, while other metallic ions do not induce such a change.	Zinc	198-202	H4 clustered histone 7	Homo sapiens	7-10
29596360-2	2018	Sensor H4L could show fluorescence turn-on response rapidly and significant selectivity to Cd2+ over many other metallic ions (Cu2+, Ba2+, Ca2+, K+, Cr3+, Mn2+, Sr2+, Co2+, Na+, Li+, Ni2+, Ag+, and Zn2+), and a clear change in color from colorless to yellow that can be very easily observed via the naked eyes in the existence of Cd2+, while other metallic ions do not induce such a change.	Zinc	198-202	CD2 molecule	Homo sapiens	91-94
29079702-8	2018	Most importantly, supplementation of Zn to induce MT preserved cardiac Akt2 signals and prevented DCM.	Zinc	37-39	thymoma viral proto-oncogene 2	Mus musculus	71-75
28822092-0	2018	Zn(II) can mediate self-association of the extracellular C-terminal domain of CD147.	Zinc	0-6	basigin (Ok blood group)	Homo sapiens	78-83
29389900-1	2018	A distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role.	Zinc	75-79	G protein-coupled receptor 39	Homo sapiens	85-90
29389900-1	2018	A distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role.	Zinc	133-137	G protein-coupled receptor 39	Homo sapiens	85-90
29389900-3	2018	ZnR/GPR39 activity was also described in neurons that are postsynaptic to vesicular Zn2+ release.	Zinc	84-88	G protein-coupled receptor 39	Homo sapiens	4-9
29283372-11	2017	Further mechanistic study demonstrated that curcumin-Cu(II) or -Zn(II) complexes systems inhibited cell apoptosis via downregulating the nuclear factor kappaB (NF-kappaB) pathway and upregulating Bcl-2/Bax pathway.	Zinc	64-70	BCL2 associated X, apoptosis regulator	Rattus norvegicus	202-205
29181969-4	2017	We observe that one DNA (MB2) will open its hairpin structure upon partial hybridization with target miR-21 after entering into cells, and the other part of its hairpin structure could further react with the other hairpin DNA (MB1) to form a Zn2+-specific DNAzyme.	Zinc	242-246	microRNA 21	Homo sapiens	101-107
29203661-2	2017	The Zn2+-dependent class IIb enzyme HDAC6 regulates microtubule function by deacetylating alpha-tubulin, which suppresses microtubule dynamics and leads to cell cycle arrest and apoptosis.	Zinc	4-8	histone deacetylase 6	Danio rerio	36-41
29203661-5	2017	These structures reveal that an unusual monodentate Zn2+ coordination mode is exploited by sterically bulky HDAC6-selective phenylhydroxamate inhibitors.	Zinc	52-56	histone deacetylase 6	Danio rerio	108-113
28963956-0	2017	Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies.	Zinc	6-12	albumin	Bos taurus	148-151
28683540-7	2017	In addition, the absorption and emission optical properties of Zn x Cd1 - x S QDs were red shifted with increasing the amount of Cd2+ in the alloyed nanocrystals, which have also increased the quantum yield compared to pure CdS and ZnS nanoparticles.	Zinc	63-65	CD2 molecule	Homo sapiens	129-132
28683540-7	2017	In addition, the absorption and emission optical properties of Zn x Cd1 - x S QDs were red shifted with increasing the amount of Cd2+ in the alloyed nanocrystals, which have also increased the quantum yield compared to pure CdS and ZnS nanoparticles.	Zinc	232-235	CD2 molecule	Homo sapiens	129-132
29234698-3	2018	The determined heavy metal concentration found in the order of Mn&gt; Ba &gt; V &gt; Cr &gt; Zn &gt; La &gt; Ni &gt;Pb&gt; Co &gt; As &gt; Cd &gt; Cu &gt; Al &gt; Fe &gt;Ca&gt; Ti &gt; K &gt; Mg.	Zinc	93-95	beta-1,4-galactosyltransferase 5	Homo sapiens	74-79
28892676-8	2017	The Zn2+ complex binds to the grooves of the DNA without inducing conformational changes or exhibiting chemical nuclease activity.	Zinc	4-8	nuclease	Escherichia coli	112-120
28937750-4	2017	Varied deacetylase activities of Fe(II)- and Zn(II)-HDAC8 toward an array of peptide substrates were identified using self-assembled monolayers for matrix-assisted laser desorption ionization (SAMDI) mass spectrometry.	Zinc	45-51	histone deacetylase 8	Homo sapiens	52-57
28261760-11	2017	Further, protein expressions of p53 and NF-KB were found to be significantly elevated after X-irradiation, which were reversed following Zn supplementation.	Zinc	137-139	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	32-35
28261760-11	2017	Further, protein expressions of p53 and NF-KB were found to be significantly elevated after X-irradiation, which were reversed following Zn supplementation.	Zinc	137-139	nuclear factor kappa B subunit 1	Rattus norvegicus	40-45
28787130-10	2017	TRPM7 and GPR39 appear to be the major cellular receptors facilitating Zn2+-entry into hMSC.	Zinc	71-75	G protein-coupled receptor 39	Homo sapiens	10-15
28710689-9	2017	PC1 included major ions Si, Co, Se, and Zn, suggesting that these are derived by rock weathering.	Zinc	40-42	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
28427888-7	2017	Inhibitors of the dopamine D1-like receptor, protein kinase A (PKA), and NOS suppressed the dopamine-induced elevation of [Zn2+]i.	Zinc	123-127	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	45-61
28427888-7	2017	Inhibitors of the dopamine D1-like receptor, protein kinase A (PKA), and NOS suppressed the dopamine-induced elevation of [Zn2+]i.	Zinc	123-127	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	63-66
29137232-7	2017	Searching our published microRNA profile, we find that the tumor-suppressor miR-143, a negative regulator of HK2, is down-regulated in Zn-deficient esophagus.	Zinc	135-137	microRNA 143	Rattus norvegicus	76-83
28483976-3	2017	This apoptosis-enabling mechanism is initiated via Zn2+-dependent dual phosphorylation of Kv2.1, increasing the interaction between the channel"s intracellular C-terminus domain and the SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor) protein syntaxin 1A.	Zinc	51-55	syntaxin 1A	Homo sapiens	272-283
28390674-9	2017	Western blots showed that Zn2+ (10 and 100 mumol/L) suppressed Cd2+-induced apoptosis (10 mumol/L) by reducing cytochrome c release into the cytosol, and downregulating the proapoptotic protein, Bax.	Zinc	26-30	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
28101932-11	2017	Long-term application of high concentration of zinc(II) significantly enhanced cisplatin resistance, invasiveness, cellular antioxidant capacity, synthesis of glutathione, and expression of treatment resistance- and stemness-associated genes (SOX2, POU5F1, BIRC5).	Zinc	47-55	POU class 5 homeobox 1	Homo sapiens	249-255
28069220-2	2017	An ultrasonic-promoted rapid TLP bonding with an interlayer of pure Zn was developed to join fine-grained 7034 aluminum alloys at the temperature of lower 400 C. The oxide film could be successfully removed with the ultrasonic vibration, and the Al-Zn eutectic liquid phase generated once Al and Zn contacted with each other.	Zinc	68-70	cysteine rich protein 3	Homo sapiens	29-32
28069220-2	2017	An ultrasonic-promoted rapid TLP bonding with an interlayer of pure Zn was developed to join fine-grained 7034 aluminum alloys at the temperature of lower 400 C. The oxide film could be successfully removed with the ultrasonic vibration, and the Al-Zn eutectic liquid phase generated once Al and Zn contacted with each other.	Zinc	249-251	cysteine rich protein 3	Homo sapiens	29-32
28427190-4	2017	Pygopus2 (Pygo2), which contains a Zn-coordinated plant homeodomain (PHD) finger domain, is critical for beta-catenin-dependent transcriptional switches in normal and malignant tissues and is over-expressed in various cancers, including human brain glioma.	Zinc	35-37	catenin beta 1	Homo sapiens	105-117
28473060-13	2017	In conclusion, Zn supplementation prevents bone alteration in chronic OVX/T1DM rats, as demonstrated by the reduced RANKL/OPG ratio and preservation of bone architecture.	Zinc	15-17	TNF receptor superfamily member 11B	Rattus norvegicus	122-125
28772691-6	2017	We prove that LiF-doped ZnO is the only codoped system that exhibits a p-type character in the presence of Zn vacancies.	Zinc	24-26	LIF interleukin 6 family cytokine	Homo sapiens	14-17
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	protein tyrosine kinase 2 beta	Homo sapiens	212-216
27923210-1	2017	The energetics and the impact on the conformation of heme containing protein myoglobin (Mb) due to the binding of three transition metal ions (Zn2+, Ni2+, and Mn2+) have been investigated using isothermal titration calorimetry (ITC), dynamic light scattering (DLS), UV-vis, and circular dichroism (CD) spectroscopy under physiological conditions.	Zinc	143-147	myoglobin	Homo sapiens	77-86
27923210-1	2017	The energetics and the impact on the conformation of heme containing protein myoglobin (Mb) due to the binding of three transition metal ions (Zn2+, Ni2+, and Mn2+) have been investigated using isothermal titration calorimetry (ITC), dynamic light scattering (DLS), UV-vis, and circular dichroism (CD) spectroscopy under physiological conditions.	Zinc	143-147	myoglobin	Homo sapiens	88-90
27923210-4	2017	Both light scattering and CD results demonstrates that the binding of Zn2+ and Mn2+ ions with Mb results in the folding whereas Ni2+ ion results in the unfolding of the protein.	Zinc	70-74	myoglobin	Homo sapiens	94-96
27923210-6	2017	The results of these studies reveals that Mn2+ ion influences the biological functions of Mb to a larger extent in spite of its lowest affinity followed by Zn2+ and Ni2+ ions.	Zinc	156-160	myoglobin	Homo sapiens	90-92
28386184-4	2017	Under the optimal experimental conditions, no interference was observed for the determination of 100 ng mL-1 Ag+ in the presence of various cations below their maximum concentrations allowed in this method, for instance, 50 mug mL-1 for both Zn2+ and Cu2+, 80 mug mL-1 for Pb2+, 1000 mug mL-1 for Mn2+, and 100 mug mL-1 for both Cd2+ and Ni2+.	Zinc	242-246	L1 cell adhesion molecule	Mus musculus	228-232
28386184-4	2017	Under the optimal experimental conditions, no interference was observed for the determination of 100 ng mL-1 Ag+ in the presence of various cations below their maximum concentrations allowed in this method, for instance, 50 mug mL-1 for both Zn2+ and Cu2+, 80 mug mL-1 for Pb2+, 1000 mug mL-1 for Mn2+, and 100 mug mL-1 for both Cd2+ and Ni2+.	Zinc	242-246	L1 cell adhesion molecule	Mus musculus	228-232
28386184-4	2017	Under the optimal experimental conditions, no interference was observed for the determination of 100 ng mL-1 Ag+ in the presence of various cations below their maximum concentrations allowed in this method, for instance, 50 mug mL-1 for both Zn2+ and Cu2+, 80 mug mL-1 for Pb2+, 1000 mug mL-1 for Mn2+, and 100 mug mL-1 for both Cd2+ and Ni2+.	Zinc	242-246	L1 cell adhesion molecule	Mus musculus	228-232
28045522-1	2017	The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn2+.	Zinc	87-91	G protein-coupled receptor 39	Homo sapiens	4-33
28045522-1	2017	The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn2+.	Zinc	87-91	G protein-coupled receptor 39	Homo sapiens	35-40
28045522-7	2017	Highly selective, highly potent Zn2+-independent GPR39 agonists were found in subsequent minilibraries.	Zinc	32-36	G protein-coupled receptor 39	Homo sapiens	49-54
27981329-0	2017	Replacement of quinolines with isoquinolines affords target metal ion switching from Zn2+ to Cd2+ in the fluorescent sensor TQLN (N,N,N",N"-tetrakis(2-quinolylmethyl)-2,6-bis(aminomethyl)pyridine).	Zinc	85-89	CD2 molecule	Homo sapiens	93-96
27981329-1	2017	A quinoline-based heptadentate ligand, N,N,N",N"-tetrakis(2-quinolylmethyl)-2,6-bis(aminomethyl)pyridine (TQLN), exhibits a Zn2+-specific fluorescence increase at 428 nm, which is assigned to excimer emission (IZn/I0 = 38, ICd/IZn = 24%, phiZn = 0.069).	Zinc	124-128	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Homo sapiens	223-226
27983814-3	2017	The progressive substitution of the nonmagnetic Zn2+ cation for Co2+ rapidly destroys the antiferromagnetic transition present at 46 K in the quasi-one-dimensional Ba2CoS3, leading to paramagnetic behavior down to the lowest investigated temperature (5 K) for compounds with x &gt; 0.25.	Zinc	48-52	complement C2	Homo sapiens	64-67
27885434-9	2017	The expression levels of miR-21, miR-31, miR-93 and miR-375 were different when Zn levels were varied in EC cell lines, but only miR-21 and miR-375 were associated with patient characteristics and prognosis in patients with EC from an area of China with a high incidence of EC.	Zinc	80-82	microRNA 21	Homo sapiens	25-31
26965689-8	2017	Disturbances in Zn2+ homeostasis impair mitochondrial and lysosomal function which leads to loss of mitochondrial bioenergetic capacity and accumulation of lysosomal substrates such as alpha-synuclein and lipofuscin.	Zinc	16-20	synuclein alpha	Homo sapiens	185-200
26965689-9	2017	Additionally, ATP13A2 appears to be involved in alpha-synuclein externalisation through its Zn2+-regulating activity.	Zinc	92-96	synuclein alpha	Homo sapiens	48-63
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Zinc	240-244	histone deacetylase 8	Homo sapiens	0-21
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Zinc	240-244	histone deacetylase 8	Homo sapiens	23-28
27668715-2	2016	Metal contents showed a descending order of Zn &gt; Cu &gt; Ni &gt; Al &gt; V &gt; Pb &gt; Cd &gt; Hg.	Zinc	44-46	beta-1,4-galactosyltransferase 5	Homo sapiens	72-77
27797597-2	2016	Activity of the gastrin promoter is also stimulated by exogenous Zn2+ ions.	Zinc	65-69	gastrin	Homo sapiens	16-23
27797597-7	2016	The zinc chelator N,N,N,N-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) abolished gastrin-stimulated gastrin promoter activity, and the inhibition was completely reversed by exogenous Zn2+ ions.	Zinc	188-192	gastrin	Homo sapiens	86-93
27797597-9	2016	Treatment with gastrin increased the intracellular concentration of free Zn2+ ions, and the increase was blocked by TPEN, but not by BAPTA-AM.	Zinc	73-77	gastrin	Homo sapiens	15-22
27797597-11	2016	These results, which are the first report of the existence of Zn2+ signaling downstream of CCK2R activation, suggest that zinc chelation therapies may be effective in counteracting gastrin-dependent tumor growth.	Zinc	62-66	gastrin	Homo sapiens	181-188
27647474-3	2016	Zinc (Zn) homeostasis is complex, involving both zinc importers (Zip) and zinc exporters (ZnT).	Zinc	6-8	zinc finger CCCH-type and G-patch domain containing	Homo sapiens	65-68
27833104-7	2016	Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate.	Zinc	0-2	solute carrier family 30 member 5	Homo sapiens	162-169
27833104-7	2016	Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate.	Zinc	0-2	solute carrier family 30 member 6	Homo sapiens	174-181
27578248-3	2016	The results are interpreted to evaluate the influence of Zn(2+) chelators on cell-free potency and on cellular permeability of DACs, and to propose novel avenues towards more potent antitumoral DACs based on Smac mimetics and Zn(2+) chelation.	Zinc	57-59	diablo IAP-binding mitochondrial protein	Homo sapiens	208-212
27501363-3	2016	Synaptically released Zn2+ activates a metabotropic Gq-coupled Zn2+ -sensing receptor, mZnR/GPR39, and induces Ca2+ -signaling in post-synaptic neurons.	Zinc	22-26	G protein-coupled receptor 39	Homo sapiens	92-97
27501363-5	2016	Following acute or chronic treatment with Abeta neuronal Zn2+ -dependent Ca2+ release via mZnR/GPR39 is significantly reduced.	Zinc	57-61	G protein-coupled receptor 39	Homo sapiens	95-100
27501363-7	2016	The Zn2+ -dependent mZnR/GPR39 activation triggers phosphorylation of extracellular regulated kinase and up-regulates expression of the chaperone protein clusterin (Clu).	Zinc	4-8	G protein-coupled receptor 39	Homo sapiens	25-30
27501363-8	2016	Importantly, neuronal Zn2+ -dependent extracellular regulated kinase1/2 phosphorylation and up-regulation of Clu are attenuated by silencing mZnR/GPR39 as well as by Abeta treatment.	Zinc	22-26	G protein-coupled receptor 39	Homo sapiens	146-151
27501363-10	2016	Thus, Zn2+ signaling via mZnR/GPR39 is distinctively disrupted by a critical pathological component of Alzheimer"s disease.	Zinc	6-10	G protein-coupled receptor 39	Homo sapiens	30-35
27501363-11	2016	Synaptically released Zn2+ activates a Zn2+ -sensing receptor, mZnR/GPR39, and induces Ca2+ -signaling, followed by ERK1/2 MAPK activation and up-regulation of clusterin.	Zinc	22-26	G protein-coupled receptor 39	Homo sapiens	68-73
26497033-6	2016	Zn caused neurobehavioral impairments and reduction in dopamine and its metabolites, tyrosine hydroxylase (TH)-positive neurons, catalase activity, and expression of TH, Bcl-2, and NOXA.	Zinc	0-2	phorbol-12-myristate-13-acetate-induced protein 1	Rattus norvegicus	181-185
26497033-7	2016	On the contrary, Zn augmented lipid peroxidation, activity of superoxide dismutase, expression of TNF-alpha, IL-1beta, Bcl-xl, and p53-upregulated modulator of apoptosis (PUMA), and translocation of NF-kappaB and Bax from the cytosol to the nucleus and mitochondria, respectively, with concomitant increase in the mitochondrial cytochrome c release and activation of procaspase-3 and -9.	Zinc	17-19	BCL2 associated X, apoptosis regulator	Rattus norvegicus	213-216
27377864-2	2016	Different kinetic and thermodynamic selectivity profiles were obtained by varying the moiety occupying an 11A channel leading to the Zn(2+) catalytic pocket of HDACs 1 and 2, two paralogs with a high degree of structural similarity.	Zinc	133-139	histone deacetylase 1	Mus musculus	160-173
27574401-8	2016	RESULTS: Since Glo-I is a zinc metalloenzyme, a customized Zn-binding pharmacophoric feature was used to search for selective inhibitors via virtual screening of a small-molecule database.	Zinc	59-61	glyoxalase I	Homo sapiens	15-20
27297986-8	2016	This was mainly due to Zn-induced enhancement of the JA/ETH signaling pathway leading to enhanced PAD3 expression.	Zinc	23-25	Cytochrome P450 superfamily protein	Arabidopsis thaliana	98-102
26996235-5	2016	HDAC8 has traditionally been considered to be a Zn-dependent enzyme.	Zinc	48-50	histone deacetylase 8	Homo sapiens	0-5
26996235-14	2016	We predict Co(2+) and Zn(2+) to be the most active metals in HDAC8, followed by Fe(2+), and Mn(2+) and Mg(2+) to be the least active.	Zinc	22-28	histone deacetylase 8	Homo sapiens	61-66
25764516-7	2016	Besides, Zn increased an association of NADPH oxidase subunit p67(phox) with membrane, cytochrome c release from the mitochondria and cleavage of pro-caspase 3.	Zinc	9-11	methionyl aminopeptidase 2	Rattus norvegicus	62-65
27129919-5	2016	Here, the authors elucidate the mechanism of this inhibition and demonstrate that it occurs through the direct interaction of the MAP Tag and the Zn(2+) binding site in the MMP-8 active site.	Zinc	146-152	matrix metallopeptidase 8	Homo sapiens	173-178
26507438-12	2016	In the duodenum, adding 60 or 90 mg Zn/kg increased PepT1 expression, but in the jejunum, 60 mg Zn/kg did not differ from 0 added Zn.	Zinc	36-38	solute carrier family 15 member 1	Rattus norvegicus	52-57
26951338-3	2016	Furthermore, the application of AC1, AC2, AC3, AC4 on different heavy metal (Cu(2+), Zn(2+), Pb(2+), Cr(3+)) removals was explored to investigate their adsorption properties.	Zinc	85-87	long intergenic non-protein coding RNA 1587	Homo sapiens	32-35
26951338-6	2016	Among the four samples, AC1 exhibits the highest adsorption capacity for Cu(2+); the highest adsorption capacities of Pb(2+) and Zn(2+) are obtained for AC2; that of Cr(3+) are obtained for AC4.	Zinc	129-131	long intergenic non-protein coding RNA 1587	Homo sapiens	24-27
26979775-6	2016	Functional expression of ZIP1 in astrocytes was evaluated by means of (65)Zn uptake, Western blotting and immunocytochemical analysis.	Zinc	74-76	solute carrier family 39 (zinc transporter), member 1	Mus musculus	25-29
26978358-1	2016	The early cysteine-labeled metallothionein (MT) from Triticum aestivum (common wheat), denoted Ec-1, features two structurally well-defined domains, gamma and betaE, coordinating two and four Zn(II) ions, respectively.	Zinc	192-194	metallothionein-like protein 1	Triticum aestivum	27-42
26978358-1	2016	The early cysteine-labeled metallothionein (MT) from Triticum aestivum (common wheat), denoted Ec-1, features two structurally well-defined domains, gamma and betaE, coordinating two and four Zn(II) ions, respectively.	Zinc	192-194	metallothionein-like protein 1	Triticum aestivum	44-46
26559751-10	2016	This splice site mutation leads to 4 bp of exon 18 skipping out causing frame shift p.Gly590Glufs*28 that ends up with a loss of active site and Zn(2+)-binding site of PHEX, which probably interfere with renal phosphate reabsorption and bone mineralization.	Zinc	145-151	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	168-172
26548864-8	2016	We succeeded in forming amyloid-like aggregates of Sg1 full length and Sg1 (1-159) fragment showing detergent stability and found that presence of Zn2+ substantially inhibits their amyloid aggregation in vitro.	Zinc	147-151	semenogelin 1	Homo sapiens	51-54
26548864-8	2016	We succeeded in forming amyloid-like aggregates of Sg1 full length and Sg1 (1-159) fragment showing detergent stability and found that presence of Zn2+ substantially inhibits their amyloid aggregation in vitro.	Zinc	147-151	semenogelin 1	Homo sapiens	71-74
26548864-9	2016	Possibly, high Zn2+ found in seminal plasma of young individuals may have preventive role against aggregation of Sg1 in seminal vesicles.	Zinc	15-19	semenogelin 1	Homo sapiens	113-116
26529669-7	2015	RESULTS: Minor alleles of rs28366003 and rs10636 near the MT2A gene were associated with lower urinary Cd, Cu, and Zn.	Zinc	115-117	metallothionein 2A	Homo sapiens	58-62
26529669-8	2015	Minor alleles of rs8044719 and rs1599823, near MT1A and MT1B, were associated with lower urinary Cd and Zn, respectively.	Zinc	104-106	metallothionein 1B	Homo sapiens	56-60
26409456-2	2015	miR-548n increased 57 % in Zn supplemented plasma from adolescent females (ages 9 to 13 years).	Zinc	27-29	microRNA 548n	Homo sapiens	0-8
26409456-3	2015	The purpose of this study was to determine the effects of Zn concentration in cell culture on the expression of miR-548n, SMAD4 and SMAD5 in hepatocyte (HepG2) and lung epithelium (HEp-2) cell lines.	Zinc	58-60	microRNA 548n	Homo sapiens	112-120
26409456-8	2015	HEp-2 miR-548n expression increased 23-fold, while SMAD4 expression decreased twofold, in 50 muM Zn-treated cells.	Zinc	97-99	microRNA 548n	Homo sapiens	6-14
26409456-10	2015	These data indicate that miR-548n expression is in part regulated by Zn in a cell-specific manner.	Zinc	69-71	microRNA 548n	Homo sapiens	25-33
26409456-11	2015	SMAD4 and SMAD5 are genes in the TGF-beta/BMP signaling pathway, and SMAD5 is a putative target for miR-548n; Zn participates in regulating this pathway through controlling SMAD4 and SMAD5 expression.	Zinc	110-112	microRNA 548n	Homo sapiens	100-108
26522088-9	2015	The data suggest that CPI-1 prevents SNAP-25 from accessing the Balc active site by blocking both the substrate binding path at the surface and the Zn(2+) binding region involved in catalysis.	Zinc	148-150	synaptosome associated protein 25	Homo sapiens	37-44
26361342-0	2015	High temperature continuous flow synthesis of CdSe/CdS/ZnS, CdS/ZnS, and CdSeS/ZnS nanocrystals.	Zinc	55-58	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
26361342-0	2015	High temperature continuous flow synthesis of CdSe/CdS/ZnS, CdS/ZnS, and CdSeS/ZnS nanocrystals.	Zinc	64-67	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
26361342-5	2015	The CdSe/CdS/ZnS particles synthesized at elevated temperatures in the reactor exhibit quantum yields of over 60% at longer wavelengths (red region).	Zinc	13-16	CDP-diacylglycerol synthase 1	Homo sapiens	4-7
26301820-7	2015	Based on the release of Zn(2+) in zinc finger domains of EGR1 upon contact with the ECL-inactive PPIX, which was monitored by circular dichroism and UV-absorption, a sensitive Zn(2+)-selective electrode for the "signal-on" detection of EGR1 was prepared with a detection limit down to 0.48 pg mL(-1) and a linearity over 6 orders of magnitude.	Zinc	24-26	early growth response 1	Homo sapiens	57-61
26301820-7	2015	Based on the release of Zn(2+) in zinc finger domains of EGR1 upon contact with the ECL-inactive PPIX, which was monitored by circular dichroism and UV-absorption, a sensitive Zn(2+)-selective electrode for the "signal-on" detection of EGR1 was prepared with a detection limit down to 0.48 pg mL(-1) and a linearity over 6 orders of magnitude.	Zinc	24-26	early growth response 1	Homo sapiens	236-240
26301820-7	2015	Based on the release of Zn(2+) in zinc finger domains of EGR1 upon contact with the ECL-inactive PPIX, which was monitored by circular dichroism and UV-absorption, a sensitive Zn(2+)-selective electrode for the "signal-on" detection of EGR1 was prepared with a detection limit down to 0.48 pg mL(-1) and a linearity over 6 orders of magnitude.	Zinc	24-30	early growth response 1	Homo sapiens	57-61
26301820-7	2015	Based on the release of Zn(2+) in zinc finger domains of EGR1 upon contact with the ECL-inactive PPIX, which was monitored by circular dichroism and UV-absorption, a sensitive Zn(2+)-selective electrode for the "signal-on" detection of EGR1 was prepared with a detection limit down to 0.48 pg mL(-1) and a linearity over 6 orders of magnitude.	Zinc	24-30	early growth response 1	Homo sapiens	236-240
25562657-5	2015	Importantly, kainate-induced synaptic Zn(2+) release enhances surface expression and transport activity of KCC2 in WT, but not mZnR/GPR39 KO hippocampal neurons.	Zinc	38-40	solute carrier family 12, member 5	Mus musculus	107-111
26187352-0	2015	Engineering of a disulfide loop instead of a Zn binding loop restores the anti-proliferative, anti-angiogenic and anti-tumor activities of the N-terminal fragment of endostatin: Mechanistic and therapeutic insights.	Zinc	45-47	collagen type XVIII alpha 1 chain	Homo sapiens	166-176
26244839-3	2015	(2015) present the first crystal structure of human nCDase and show how complexation with phosphate supports a new catalytic mechanism for Zn-dependent amidases while providing a structurally based explanation for ceramide specificity.	Zinc	139-141	N-acylsphingosine amidohydrolase 2	Homo sapiens	52-58
26058002-0	2015	The influence of zinc(II) on thioredoxin/glutathione disulfide exchange: QM/MM studies to explore how zinc(II) accelerates exchange in higher dielectric environments.	Zinc	102-110	thioredoxin	Homo sapiens	29-40
25801306-4	2015	Here, we show that the Zn-binding metallothionein (MT) proteins are essential for the FceRI-induced basophil production of IL-4.	Zinc	23-25	interleukin 4	Mus musculus	123-127
25801306-7	2015	These results suggest that the MT-dependent control of Zn homeostasis is a novel mechanism for regulating basophil IL-4 production.	Zinc	55-57	interleukin 4	Mus musculus	115-119
26266739-0	2015	Controlling Charge Carrier Overlap in Type-II ZnSe/ZnS/CdS Core-Barrier-Shell Quantum Dots.	Zinc	46-49	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
25088245-6	2015	Zn accumulated in the mammary glands of Zn deficient mice and this was associated with macrophage infiltration, enhanced oxidative stress and over-expression of estrogen receptor alpha.	Zinc	0-2	estrogen receptor 1 (alpha)	Mus musculus	161-184
25088245-6	2015	Zn accumulated in the mammary glands of Zn deficient mice and this was associated with macrophage infiltration, enhanced oxidative stress and over-expression of estrogen receptor alpha.	Zinc	40-42	estrogen receptor 1 (alpha)	Mus musculus	161-184
26017872-6	2015	To suppress the interfacial recombination between Ag NWs and the CdS film, a Zn(S,O,OH) film was introduced as a hole-blocking layer between the CdS film and Ag NW network.	Zinc	77-79	CDP-diacylglycerol synthase 1	Homo sapiens	65-68
26017872-6	2015	To suppress the interfacial recombination between Ag NWs and the CdS film, a Zn(S,O,OH) film was introduced as a hole-blocking layer between the CdS film and Ag NW network.	Zinc	77-79	CDP-diacylglycerol synthase 1	Homo sapiens	145-148
26016528-4	2015	Herein, we separate the energetic contributions of metal-ligand interactions from those of protein-protein interactions using a natural protein scaffold that retains essentially identical structures with and without Zn(II) bound, the 59 amino acid zinc binding domain of human transcription factor IIB (ZBD-TFIIB).	Zinc	216-222	cilia and flagella associated protein 20	Homo sapiens	277-301
25766873-3	2015	Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1"s active site similar to His-69 in Endo IV.	Zinc	113-117	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	126-130
25766873-4	2015	Substituting His-83 with Ala is proposed to decrease the AP endonuclease activity of Apn1 owing to weak coordination of Zn2+ ions involved in enzymatic catalysis.	Zinc	120-124	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	85-89
25766873-10	2015	Our data prove suppressed enzymatic activity of H83A Apn1 results from the reduced number of active site Zn2+ ions.	Zinc	105-109	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	53-57
25755079-8	2015	Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p &lt; 0.05).	Zinc	67-69	solute carrier family 39 member 1	Homo sapiens	14-18
25854679-6	2015	Taken together, Zn(2+) inhibits PP2A directly through binding to PP2Ac(51-270) in vitro.	Zinc	16-22	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	65-70
25981743-5	2015	Postsynaptic Zn is mainly derived from presynaptic pools and activates NMDA receptors (NMDARs) through postsynaptic activation of the tyrosine kinase Src.	Zinc	13-15	Rous sarcoma oncogene	Mus musculus	150-153
25981743-7	2015	These results suggest that trans-synaptic Zn mobilization induced by clioquinol rescues social deficits in mouse models of ASD through postsynaptic Src and NMDAR activation.	Zinc	42-44	Rous sarcoma oncogene	Mus musculus	148-151
25981743-7	2015	These results suggest that trans-synaptic Zn mobilization induced by clioquinol rescues social deficits in mouse models of ASD through postsynaptic Src and NMDAR activation.	Zinc	42-44	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	156-161
25724285-5	2015	While Zn and/or PQ elevated the total free radical generation, lipid peroxidation (LPO) and catalytic activity of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase alpha 4-4 (GSTA4-4), a pronounced decrease in reduced glutathione (GSH) and glutathione reductase (GR) activity was also observed.	Zinc	6-8	glutathione S-transferase alpha 4	Rattus norvegicus	235-242
25434301-6	2015	Plasma Zn correlated positively with plasma leptin (r=0.746, P&lt;0.01), Cu-Zn SOD (r=0.827, P&lt;0.01), and negatively with percent fat mass (r=-0.598, P&lt;0.05) under no-training conditions.	Zinc	7-9	leptin	Homo sapiens	44-50
25434301-8	2015	In conclusion, plasma Zn may be involved in the regulation of plasma leptin and may serve as a lipid-mobilizing factor in Chinese men"s basketball athletes.	Zinc	22-24	leptin	Homo sapiens	69-75
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	61-67	histone deacetylase 8	Homo sapiens	0-21
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	61-67	histone deacetylase 8	Homo sapiens	23-28
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	61-67	histone deacetylase 8	Homo sapiens	123-128
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	0-21
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	23-28
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	123-128
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	0-21
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	23-28
25516458-1	2015	Histone deacetylase 8 (HDAC8) was originally classified as a Zn(II)-dependent deacetylase on the basis of Zn(II)-dependent HDAC8 activity in vitro and illumination of a Zn(II) bound to the active site.	Zinc	106-112	histone deacetylase 8	Homo sapiens	123-128
25516458-3	2015	These data suggest that in the cell HDAC8 could be activated by either Zn(II) or Fe(II).	Zinc	71-77	histone deacetylase 8	Homo sapiens	36-41
25516458-4	2015	Here we detail the kinetics, thermodynamics, and selectivity of Zn(II) and Fe(II) binding to HDAC8.	Zinc	64-70	histone deacetylase 8	Homo sapiens	93-98
25516458-8	2015	The metal KD values for HDAC8 are significantly different, ranging from picomolar to micromolar for Zn(II) and Fe(II), respectively.	Zinc	100-106	histone deacetylase 8	Homo sapiens	24-29
25516458-9	2015	Unexpectedly, the Fe(II) and Zn(II) dissociation rate constants from HDAC8 are comparable, koff ~0.0006 s(-1), suggesting that the apparent association rate constant for Fe(II) is slow (~3 x 10(3) M(-1) s(-1)).	Zinc	29-35	histone deacetylase 8	Homo sapiens	69-74
25516458-10	2015	Furthermore, monovalent cations (K(+) or Na(+)) that bind to HDAC8 decrease the dissociation rate constant of Zn(II) by &gt;=100-fold for K(+) and &gt;=10-fold for Na(+), suggesting a possible mechanism for regulating metal exchange in vivo.	Zinc	110-112	histone deacetylase 8	Homo sapiens	61-66
25970885-1	2015	ZnS/CdS composite window layer was prepared by magnetron sputtering method and then applied to CdTe solar cell.	Zinc	0-3	CDP-diacylglycerol synthase 1	Homo sapiens	4-7
25970885-6	2015	Particularly, the quantum efficiency of CdTe solar cells with ZnS/CdS window layer was measured.	Zinc	62-65	CDP-diacylglycerol synthase 1	Homo sapiens	66-69
25970885-10	2015	The performance of CdTe solar cells with ZnS/CdS window layer is much better if ZnS deposited at 250 degrees C. This indicates grain size has some effect on the electron transportation.	Zinc	80-83	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
25970885-11	2015	When the CdS holds the same thickness, the transmission of ZnS/CdS window layer was improved about 2% in short wavelength compared with CdS window layer.	Zinc	59-62	CDP-diacylglycerol synthase 1	Homo sapiens	9-12
25970885-11	2015	When the CdS holds the same thickness, the transmission of ZnS/CdS window layer was improved about 2% in short wavelength compared with CdS window layer.	Zinc	59-62	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
25970885-11	2015	When the CdS holds the same thickness, the transmission of ZnS/CdS window layer was improved about 2% in short wavelength compared with CdS window layer.	Zinc	59-62	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
25970885-12	2015	The quantum efficiency of CdTe solar cells with ZnS/CdS window layer was also improved about 2% in short wavelength compared with that based on CdS window layer.	Zinc	48-51	CDP-diacylglycerol synthase 1	Homo sapiens	52-55
25970885-13	2015	These indicate ZnS/CdS composite window layer can increase the photon transmission in short wavelength so that more photons can be absorbed by the absorbent layer of CdTe solar cells.	Zinc	15-18	CDP-diacylglycerol synthase 1	Homo sapiens	19-22
26031074-4	2015	(2) Multivariate statistical analysis shows that 8 heavy metals can be classified to 2 principle components, among which PC1 ( Cd, Pb, Hg and Zn) is man-made source factor and mainly came from all kinds of waste of agriculture; PC2 ( Cu, Ni, Cr and As) is natural source and was mainly controlled by the background of the natural geography of this area.	Zinc	142-144	polycystin 1, transient receptor potential channel interacting	Homo sapiens	121-124
26031074-4	2015	(2) Multivariate statistical analysis shows that 8 heavy metals can be classified to 2 principle components, among which PC1 ( Cd, Pb, Hg and Zn) is man-made source factor and mainly came from all kinds of waste of agriculture; PC2 ( Cu, Ni, Cr and As) is natural source and was mainly controlled by the background of the natural geography of this area.	Zinc	142-144	chromobox 4	Homo sapiens	228-231
26031076-5	2015	Cd, Pb and Zn, having high loads in PC1, were dominated by industrial, agricultural and traffic sources.	Zinc	11-13	proprotein convertase subtilisin/kexin type 1	Homo sapiens	36-39
25173525-0	2015	The bipyridine adducts of N-phenyldithiocarbamato complexes of Zn(II) and Cd(II); synthesis, spectral, thermal decomposition studies and use as precursors for ZnS and CdS nanoparticles.	Zinc	63-69	CDP-diacylglycerol synthase 1	Homo sapiens	167-170
25973311-1	2015	A seminal plasma protein, semenogelin I (SgI), contributes to sperm clotting, upon binding to Zn(2+), and can be proteolyzed by prostate-specific antigen (PSA), resulting in release of the trapped spermatozoa after ejaculation.	Zinc	94-96	semenogelin 1	Homo sapiens	26-39
25973311-1	2015	A seminal plasma protein, semenogelin I (SgI), contributes to sperm clotting, upon binding to Zn(2+), and can be proteolyzed by prostate-specific antigen (PSA), resulting in release of the trapped spermatozoa after ejaculation.	Zinc	94-96	semenogelin 1	Homo sapiens	41-44
25486072-6	2015	The energetically favored Zn chelation sites of the 1:1 complex were found to be either the C-3 O(-) and CO-4 or C-5 O(-) and CO-4 sites, depending on the functional used, for quercetin and the C-5 O(-) and CO-4 sites for luteolin.	Zinc	26-28	complement C5	Homo sapiens	113-116
25486072-6	2015	The energetically favored Zn chelation sites of the 1:1 complex were found to be either the C-3 O(-) and CO-4 or C-5 O(-) and CO-4 sites, depending on the functional used, for quercetin and the C-5 O(-) and CO-4 sites for luteolin.	Zinc	26-28	complement C5	Homo sapiens	194-197
25257316-1	2015	Octacalcium phosphate (OCP) and hydroxyapatite (HAp) coatings were formed on Mg-3 mass% Al-1 mass% Zn (AZ31) magnesium alloy by a single-step chemical solution deposition method.	Zinc	99-101	scaffold attachment factor B	Mus musculus	48-51
25445539-2	2015	In this work we showed that the binding of Zn(2+) to TPPP/p25 promotes its dimerization resulting in increased tubulin polymerization promoting activity.	Zinc	43-45	tubulin polymerization promoting protein	Rattus norvegicus	53-61
25445539-3	2015	We also demonstrated that the Zn(2+) increases the intracellular TPPP/p25 level resulting in a more decorated microtubule network in CHO10 and CG-4 cells expressing TPPP/p25 ectopically and endogenously, respectively.	Zinc	30-32	tubulin polymerization promoting protein	Rattus norvegicus	65-73
25445539-3	2015	We also demonstrated that the Zn(2+) increases the intracellular TPPP/p25 level resulting in a more decorated microtubule network in CHO10 and CG-4 cells expressing TPPP/p25 ectopically and endogenously, respectively.	Zinc	30-32	tubulin polymerization promoting protein	Rattus norvegicus	165-173
25433542-7	2015	PC1 represented Cd, Cr, Ni, and Zn, while PC2 represented Pb and Cu.	Zinc	32-34	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-3
26053506-5	2015	Finally, we partially purified and identified essential metals, Fe, Zn, Co, Ni and Mn, as novel OGR1 agonists.	Zinc	68-70	G protein-coupled receptor 68	Homo sapiens	96-100
26053506-8	2015	Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.	Zinc	38-40	G protein-coupled receptor 68	Homo sapiens	70-74
26053506-8	2015	Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.	Zinc	38-40	G protein-coupled receptor 68	Homo sapiens	111-115
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	44-46	anoctamin 1	Homo sapiens	242-246
25220380-8	2014	Because TMC8 is required to lower cytosolic Zn(2+) concentrations by the Zn(2+) transporter ZnT-1, we hypothesize that HPV infections and cancer caused by mutations in TMC8 are related to upregulated Zn(2+)/Ca(2+) signaling and activation of Ano1.	Zinc	73-75	anoctamin 1	Homo sapiens	242-246
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Zinc	180-182	cystathionine beta-synthase	Mus musculus	42-69
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Zinc	180-182	cystathionine beta-synthase	Mus musculus	71-74
25517751-4	2014	In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B.	Zinc	30-32	transient receptor potential cation channel subfamily M member 3	Homo sapiens	13-18
25207938-7	2014	For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).	Zinc	59-61	histone deacetylase 8	Homo sapiens	13-34
25157674-0	2014	The -5 A/G single-nucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer.	Zinc	136-138	metallothionein 2A	Homo sapiens	73-77
25157674-3	2014	The aim of this study was to determine the -5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene and to investigate its effect on allele-specific gene expression and Cd, Zn and Cu content in squamous cell laryngeal cancer (SCC) and non-cancerous laryngeal mucosa (NCM) as a control.	Zinc	218-220	metallothionein 2A	Homo sapiens	135-139
25157674-10	2014	The Spearman rank correlation results showed that the MT2A expression and Cd, Zn, Cu levels were negatively correlated.	Zinc	78-80	metallothionein 2A	Homo sapiens	54-58
25049058-7	2014	Exogenous Zn(2+) lowers the threshold in hippocampal CA1 LTP induction in young rat.	Zinc	10-16	carbonic anhydrase 1	Rattus norvegicus	53-56
25141099-6	2014	Aluminium treatment significantly elevated the levels of lipid peroxidation and reactive oxygen species as well as the activities of catalase, superoxide dismutase and glutathione reductase, which however were decreased following Zn co-treatment of Al-treated rats.	Zinc	230-232	glutathione-disulfide reductase	Rattus norvegicus	168-189
24872539-9	2014	Furthermore, selectively blocking NaV1.5 channels with Zn(2+) in the absence of tetrodotoxin also suppressed spontaneous firing, indicating that NaV1.5 channels are required for spontaneous activity despite resting inactivation.	Zinc	55-57	sodium voltage-gated channel alpha subunit 5	Homo sapiens	34-40
24872539-9	2014	Furthermore, selectively blocking NaV1.5 channels with Zn(2+) in the absence of tetrodotoxin also suppressed spontaneous firing, indicating that NaV1.5 channels are required for spontaneous activity despite resting inactivation.	Zinc	55-57	sodium voltage-gated channel alpha subunit 5	Homo sapiens	145-151
24862443-7	2014	The ZnT1 and ZIP1 gene expression studies demonstrate that the Zn-implanted coatings can better stimulate bone growth with reduced Zn release than those doped with zinc throughout the coatings.	Zinc	63-65	solute carrier family 30 member 1	Rattus norvegicus	4-8
25042137-4	2014	The light chain is a Zn(2+) -dependent endoprotease that cleaves and inactivates SNAP-25, thereby blocking exocytotic release of transmitters, a discovery that revealed the pivotal role of the latter in synaptic vesicle fusion.	Zinc	21-27	synaptosome associated protein 25	Homo sapiens	81-88
24715002-5	2014	Visible spectra and NMR reveal that H4L with Fe(III), Cu(II), and Zn(II) can all give stable mono-(ML) and dinuclear complexes [M(ML)].	Zinc	66-72	H4 clustered histone 7	Homo sapiens	36-39
24728862-7	2014	Our data suggest that most if not all tissues use ZIP8, ZIP14A, and/or ZIP14B for Zn2+ uptake, some tissues under basal conditions and others moreso when inflammatory stressors are present; collectively, this might lead to substantial alterations in plasma Zn2+ levels due to Zn2+ redistribution not just in liver but across many vital organs.	Zinc	82-86	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	50-54
24387792-4	2014	The feeding trial lasted for 28 d. The results showed that serum diamine oxidase activities, d-lactate levels and endotoxin contents were lower in pigs fed dietary 100 mg/kg of Zn as CS-Zn or 3000 mg/kg of Zn as ZnO than in pigs fed the control or 100 mg Zn/kg as ZnSO4 diet.	Zinc	177-179	amine oxidase copper containing 1	Sus scrofa	65-80
24648263-1	2014	The syntheses and structures of two new Zn(II) complexes, a 2D graphite-like layer {[Zn(PIA)H2 O] H2 O}n (1) and an independent 1D single-walled metal-organic nanotube (SWMONT) {[Zn2 (PIA)2 (bpy)2 ] 2.5 H2 O DMA}n (2), have been reported based on a "Y"-shaped 5-(pyridine-4-yl)isophthalic acid ligand (H2 PIA).	Zinc	40-42	RPTOR independent companion of MTOR complex 2	Homo sapiens	88-91
24705372-1	2014	The redox properties of cytochrome c (Cyt c), hemoglobin (Hb) and myoglobin (Mb) were studied based on electrostatic interactions between Thioglycolic acid (TGA) capped CdSe/ZnS quantum dots (QDs) and proteins.	Zinc	174-177	myoglobin	Homo sapiens	66-75
24646264-1	2014	A number of bacterial glyoxalase I enzymes are maximally activated by Ni2+ and Co2+ ions, but are inactive in the presence of Zn2+, yet these enzymes will also bind this metal ion.	Zinc	126-130	glyoxalase I	Homo sapiens	22-34
24450572-7	2014	The oligomers formed in the presence of Zn(II) are permitted by this metal"s ability to bridge two beta2m units via His51.	Zinc	40-42	beta-2-microglobulin	Homo sapiens	99-105
24001510-4	2014	Speciation studies using potentiometric titrations have been performed for both the ligand and the corresponding dizinc complex to elucidate the formation of the active hydrolysis catalyst; they reveals that the dinuclear zinc(II) complexes, [Zn(2)(DPCPMP)](2+) and [Zn(2)(DPCPMP)(OH)](+) predominate the solution above pH4.	Zinc	222-230	prolyl 4-hydroxylase, transmembrane	Homo sapiens	320-323
24369429-4	2014	A previously uncharacterized domain 1B connects HEL1 domains 1A and 2A to a long linker of ZBD, which further consists of a novel RING-like module and treble-clef zinc finger, together coordinating three Zn atoms.	Zinc	204-206	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	Homo sapiens	48-52
24051284-1	2014	Complexes of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) with a Schiff base, formed by the condensation of isatin with 2-aminopyrimidine have been synthesised and characterised through elemental analysis, molar conductance measurements, magnetic susceptibility, IR, UV-Vis, (1)HNMR, FAB mass and EPR spectral studies.	Zinc	67-75	FA complementation group B	Homo sapiens	302-305
24694605-11	2014	These results indicate that Zn influences plasma leptin concentrations by modulating mRNA expression of soluble Ob-R in the placenta, and leptin in visceral fat during pregnancy.	Zinc	28-30	leptin receptor	Mus musculus	112-116
24132751-8	2014	We also demonstrate that Ag(I) and Zn(II), which are known to suppress hCtr1-mediated copper transport, can also induce hCtr1/Sp1 expression.	Zinc	35-37	solute carrier family 31 member 1	Homo sapiens	71-76
24132751-8	2014	We also demonstrate that Ag(I) and Zn(II), which are known to suppress hCtr1-mediated copper transport, can also induce hCtr1/Sp1 expression.	Zinc	35-37	solute carrier family 31 member 1	Homo sapiens	120-125
24033183-3	2014	In this report, barley (Hordeum vulgare) HvZIP7 was investigated for its functions in Zn transport.	Zinc	86-88	zip7	Hordeum vulgare	41-47
24033183-8	2014	Overexpression of HvZIP7 in barley plants increased Zn uptake when moderately high concentrations of Zn were supplied.	Zinc	52-54	zip7	Hordeum vulgare	18-24
24033183-8	2014	Overexpression of HvZIP7 in barley plants increased Zn uptake when moderately high concentrations of Zn were supplied.	Zinc	101-103	zip7	Hordeum vulgare	18-24
24033183-10	2014	HvZIP7 displays characteristics of low-affinity Zn transport.	Zinc	48-50	zip7	Hordeum vulgare	0-6
24033183-11	2014	The unique function of HvZIP7 provides new insights into the role of ZIP genes in Zn homeostasis in monocots, and offers opportunities to develop Zn biofortification strategies in cereals.	Zinc	82-84	zip7	Hordeum vulgare	23-29
24033183-11	2014	The unique function of HvZIP7 provides new insights into the role of ZIP genes in Zn homeostasis in monocots, and offers opportunities to develop Zn biofortification strategies in cereals.	Zinc	146-148	zip7	Hordeum vulgare	23-29
24000822-2	2014	In the present study we have performed molecular dynamics (MD) simulation of crystal structure complex of hECE-1 and its inhibitor phosphoramidon with Zn ion to understand the dynamic behavior of active site residues.	Zinc	151-153	endothelin converting enzyme 1	Homo sapiens	106-112
24328274-2	2013	The aforementioned dimer is assembled by dual amidine-Zn(II) coordination between neighboring Pc1 molecules and gives rise to high association constants (KD   10(11) M(-1)).	Zinc	54-60	polycystin 1, transient receptor potential channel interacting	Homo sapiens	94-97
24328274-3	2013	Such extraordinary stability hampers the individual binding of either carboxylic acid ligands through the amidine group or pyridine-type ligands through the Zn(II) metal atom to (Pc1)2.	Zinc	157-163	polycystin 1, transient receptor potential channel interacting	Homo sapiens	179-182
24363439-4	2014	Exposure to Zn(2)(+) ions increased gastrin mRNA concentrations in the human gastric adenocarcinoma cell line AGS in a dose-dependent manner, with a maximum stimulation of 55 +- 14-fold at 100 muM (P&lt;0.05).	Zinc	12-17	gastrin	Homo sapiens	36-43
24363439-6	2014	Activation of MAPK and phosphatidylinositol 3-kinase pathways is necessary but not sufficient for gastrin induction by Zn(2)(+).	Zinc	119-124	gastrin	Homo sapiens	98-105
24363439-7	2014	Deletional mutation of the gastrin promoter identified an 11 bp DNA sequence, which contained an E-box motif, as necessary for Zn(2)(+)-dependent gastrin induction.	Zinc	127-132	gastrin	Homo sapiens	27-34
24363439-7	2014	Deletional mutation of the gastrin promoter identified an 11 bp DNA sequence, which contained an E-box motif, as necessary for Zn(2)(+)-dependent gastrin induction.	Zinc	127-132	gastrin	Homo sapiens	146-153
24363439-8	2014	The fact that E-box binding transcription factors play a crucial role in the epithelial-mesenchymal transition (EMT), together with our observation that Zn(2)(+) ions upregulate the gastrin gene in AGS cells by an E-box-dependent mechanism, suggests that Zn(2)(+) ions may induce an EMT, and that gastrin may be involved in the transition.	Zinc	153-161	gastrin	Homo sapiens	182-189
24363439-8	2014	The fact that E-box binding transcription factors play a crucial role in the epithelial-mesenchymal transition (EMT), together with our observation that Zn(2)(+) ions upregulate the gastrin gene in AGS cells by an E-box-dependent mechanism, suggests that Zn(2)(+) ions may induce an EMT, and that gastrin may be involved in the transition.	Zinc	153-161	gastrin	Homo sapiens	297-304
24363439-8	2014	The fact that E-box binding transcription factors play a crucial role in the epithelial-mesenchymal transition (EMT), together with our observation that Zn(2)(+) ions upregulate the gastrin gene in AGS cells by an E-box-dependent mechanism, suggests that Zn(2)(+) ions may induce an EMT, and that gastrin may be involved in the transition.	Zinc	255-263	gastrin	Homo sapiens	182-189
24278106-11	2013	Finally, Zn(2+) inhibition of isolated NMDAR currents was potentiated by DTNB.	Zinc	9-11	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	39-44
24220130-2	2013	The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requires either Ni(II)/Co(II) or Zn(II) for activity.	Zinc	126-132	glyoxalase I	Homo sapiens	34-46
24044877-2	2013	We report the first experimental evidence for the in situ reduction of CoBr2(dppe) [dppe = 1,2-bis(diphenylphosphino)ethane] by Zn/ZnI2 to [Co(I)(dppe)](+) by means of electrospray MS(n) experiments.	Zinc	128-130	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	140-144
23990470-9	2013	As a consequence, heparin-catalyzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn(2+) is present.	Zinc	130-132	serpin family C member 1	Homo sapiens	63-75
24220325-0	2013	A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.	Zinc	29-35	transformation related protein 53, pseudogene	Mus musculus	81-84
24220325-2	2013	Some mutant (mt) p53 proteins are prone to loss of Zn(II) ion that is bound to the wild-type (wt) core, promoting protein aggregation and therefore unfolding.	Zinc	51-57	transformation related protein 53, pseudogene	Mus musculus	17-20
23378263-9	2013	Functional studies to establish a role for hZip1 in cellular zinc accumulation were carried out using (65)Zn.	Zinc	106-108	solute carrier family 39 member 1	Homo sapiens	43-48
23863901-2	2013	One is TLR4, which causes an increase of free zinc ions (Zn(2+)) that is required for the MyD88-dependent expression of inflammatory cytokines.	Zinc	57-59	toll like receptor 4	Homo sapiens	7-11
23863901-3	2013	This study investigates the role of Zn(2+) on Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF)-dependent signals, the other major intracellular pathway activated by TLR4.	Zinc	36-38	toll like receptor 4	Homo sapiens	46-50
23863901-3	2013	This study investigates the role of Zn(2+) on Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF)-dependent signals, the other major intracellular pathway activated by TLR4.	Zinc	36-38	toll like receptor 4	Homo sapiens	178-182
23863901-4	2013	Chelation of Zn(2+) with the membrane-permeable chelator N,N,N",N"-Tetrakis(2-pyridylmethyl)ethylenediamine augmented TLR4-mediated production of IFN-beta and subsequent synthesis of inducible NO synthase and production of NO.	Zinc	13-15	toll like receptor 4	Homo sapiens	118-122
23648111-5	2013	In this study, we examined whether Zn(2+) affects the expression of Bim in human neuroblastoma SH-SY5Y cells.	Zinc	35-37	BCL2 like 11	Homo sapiens	68-71
23648111-6	2013	Zn(2+) triggered alterations in Bim splicing and induced preferential generation of BimS, but not BimEL and BimL, in a dose- and time-dependent manner.	Zinc	0-2	BCL2 like 11	Homo sapiens	32-35
23648111-8	2013	To address the mechanism of Zn(2+)-induced preferential generation of BimS, which lacks exon 4, we developed a Bim mini-gene construct.	Zinc	28-31	BCL2 like 11	Homo sapiens	70-73
23761487-3	2013	Functional complementation of the Arabidopsis T-DNA insertion mutant mtp1-1 demonstrates that OsMTP1 transports Zn in planta and localizes at the tonoplast.	Zinc	112-114	zinc transporter	Arabidopsis thaliana	69-73
23652332-8	2013	Zn(2+) binding to Abeta42 almost completely suppressed Abeta42 fibrillization, which could be significantly restored by SelP-H and SelM", as observed by thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM).	Zinc	0-5	selectin P	Homo sapiens	120-124
23652332-9	2013	Interestingly, both SelP-H and SelM" inhibited Zn(2+)-Abeta42-induced neurotoxicity and the intracellular ROS production in living cells.	Zinc	47-53	selectin P	Homo sapiens	20-24
23651256-1	2013	Aro80, a member of the Zn(2)Cys(6) family proteins, activates expression of the ARO9 and ARO10 genes involved in catabolism of aromatic amino acids in response to aromatic amino acids that act as inducers.	Zinc	23-25	aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	80-84
23724032-0	2013	The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.	Zinc	78-81	glutamate-cysteine ligase, modifier subunit	Mus musculus	31-35
23724032-3	2013	In this study we synthesized CdSe/ZnS core/shell QDs with a tri-n-octylphosphine oxide, poly(maleic anhydride-alt-1-tetradecene) (TOPO-PMAT) coating and assessed their effects on lung inflammation in mice.	Zinc	34-37	solute carrier family 29 (nucleoside transporters), member 4	Mus musculus	135-139
23717323-10	2013	In Zn hyperaccumulator plants, the MTP1 protein is related to hypertolerance to elevated Zn concentrations.	Zinc	3-5	solute carrier family 40 member 1	Homo sapiens	35-39
23717323-10	2013	In Zn hyperaccumulator plants, the MTP1 protein is related to hypertolerance to elevated Zn concentrations.	Zinc	89-91	solute carrier family 40 member 1	Homo sapiens	35-39
23503404-6	2013	Moreover, it is also suggested that endoplasmic reticulum (ER) stress and activity-regulated cytoskeleton associated protein (Arc) are implicated in Zn-induced degeneration of neurons.	Zinc	149-151	activity regulated cytoskeletal-associated protein	Mus musculus	74-124
22710719-7	2013	Using K562 sublines with conditional MYC expression (induced by Zn(2+) or activated by 4-hydroxy-tamoxifen) we show that MYC prevented the erythroid differentiation induced by imatinib and dasatinib.	Zinc	64-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
22710719-7	2013	Using K562 sublines with conditional MYC expression (induced by Zn(2+) or activated by 4-hydroxy-tamoxifen) we show that MYC prevented the erythroid differentiation induced by imatinib and dasatinib.	Zinc	64-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	121-124
23274584-9	2013	Dietary or ZnT3-dependent Zn(2+) stores, and intracellular Zn(2+) release from rhodopsin recycling are suggested to be involved in light-induced retinal degeneration.	Zinc	59-65	rhodopsin	Mus musculus	79-88
23149916-4	2013	Our comprehensive analysis revealed allosteric binding (Kd 10-30 nmol/L) to the regulatory Zn(2+) binding domain of HDAC4 that locks the protein in a conformation preventing HDAC4/N-CoR/HDAC3 complex formation.	Zinc	91-97	histone deacetylase 4	Homo sapiens	116-121
23149916-4	2013	Our comprehensive analysis revealed allosteric binding (Kd 10-30 nmol/L) to the regulatory Zn(2+) binding domain of HDAC4 that locks the protein in a conformation preventing HDAC4/N-CoR/HDAC3 complex formation.	Zinc	91-97	histone deacetylase 4	Homo sapiens	174-179
23149916-4	2013	Our comprehensive analysis revealed allosteric binding (Kd 10-30 nmol/L) to the regulatory Zn(2+) binding domain of HDAC4 that locks the protein in a conformation preventing HDAC4/N-CoR/HDAC3 complex formation.	Zinc	91-97	nuclear receptor corepressor 1	Homo sapiens	180-185
23423544-0	2013	Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.	Zinc	85-87	matrix metallopeptidase 8	Homo sapiens	106-132
23423544-2	2013	Extensive MD-simulation of the PDB and solvated structures of hMMP-8 has revealed the presence of few conserved water molecules around the catalytic and structural zinc (ZnC and ZnS) ions.	Zinc	178-181	matrix metallopeptidase 8	Homo sapiens	62-68
24159420-2	2013	Metal ions like Cu, Fe and Zn are known to associate with the amyloid beta (A beta ) at high concentration and interaction of these ions with soluble and aggregated forms of A beta peptide help in development of AD.	Zinc	27-29	beta amyloid protein precursor-like	Drosophila melanogaster	70-82
24159420-2	2013	Metal ions like Cu, Fe and Zn are known to associate with the amyloid beta (A beta ) at high concentration and interaction of these ions with soluble and aggregated forms of A beta peptide help in development of AD.	Zinc	27-29	beta amyloid protein precursor-like	Drosophila melanogaster	76-82
24061378-2	2012	Further, the stability constants of the 1 M2+ complexes in water-saturated nitrobenzene were calculated; they were found to increase in the series of Cu2+ &lt; Ba2+ &lt; Zn2+ &lt; Ni2+ &lt; UO22+ &lt; Co2+ &lt; Mn2+ &lt; Cd2+ &lt; Ca2+ &lt; Pb2+.	Zinc	170-174	CD2 molecule	Homo sapiens	221-224
22832069-7	2012	Although the results of this study contribute to the understanding of the structural and molecular basis behind the acceleration of AS fibrillation mediated by Zn(2+), the low affinity that characterizes the interaction of Zn(2+) with AS contrasts strongly with the high-affinity features reported for the binding of this metal ion to other target proteins linked to human amylodosis such as Abeta peptide and the Islet Amyloid Polypeptide (IAPP), challenging the biological relevance of zinc interactions in the pathogenesis of PD.	Zinc	223-225	synuclein alpha	Homo sapiens	235-237
23096014-4	2012	We previously showed these mechanisms are also involved in Zn(2+) neurotoxicity and are attenuated by nicotinamide- or pyruvate-induced restoration of NAD(+) concentrations, Zn(2+) restriction, or inhibition of Sir2 proteins.	Zinc	59-61	sirtuin 1	Mus musculus	211-215
23096014-6	2012	Zn(2+), streptozotocin, and cytokines caused NAD(+) loss and death in insulinoma cells and islets, which were attenuated by Zn(2+) restriction, pyruvate, nicotinamide, NAD(+), and inhibitors of Sir2 proteins.	Zinc	0-2	sirtuin 1	Mus musculus	194-198
23096014-6	2012	Zn(2+), streptozotocin, and cytokines caused NAD(+) loss and death in insulinoma cells and islets, which were attenuated by Zn(2+) restriction, pyruvate, nicotinamide, NAD(+), and inhibitors of Sir2 proteins.	Zinc	124-126	sirtuin 1	Mus musculus	194-198
23090441-7	2012	Competitive inhibition of Cd and Zn uptake with ten additional divalent cations showed a unique gradient of patterns for each of ZIP14A, ZIP14B and ZIP8.	Zinc	33-35	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	148-152
23090441-10	2012	In the present study we show that these five divalent cations are usually competitors of ZIP14- and/or ZIP8-mediated Zn uptake; our data thus support the possible involvement of intestinal ZIP14 for uptake of these five metals into the body and ZIP8 for efficient uptake into the kidney.	Zinc	117-119	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	103-107
23090441-10	2012	In the present study we show that these five divalent cations are usually competitors of ZIP14- and/or ZIP8-mediated Zn uptake; our data thus support the possible involvement of intestinal ZIP14 for uptake of these five metals into the body and ZIP8 for efficient uptake into the kidney.	Zinc	117-119	solute carrier family 39 (zinc transporter), member 14 L homeolog	Xenopus laevis	189-194
23090441-10	2012	In the present study we show that these five divalent cations are usually competitors of ZIP14- and/or ZIP8-mediated Zn uptake; our data thus support the possible involvement of intestinal ZIP14 for uptake of these five metals into the body and ZIP8 for efficient uptake into the kidney.	Zinc	117-119	solute carrier family 39 (metal ion transporter), member 8	Mus musculus	245-249
23082970-5	2012	The calcium-insensitive Zn(II) competitor ZP4 affords dissociation constants of K(d1) = 133 +- 58 pM and K(d2) = 185 +- 219 nM for CP in the absence of Ca(II).	Zinc	24-30	zona pellucida glycoprotein 4	Homo sapiens	42-45
22930753-1	2012	Extracellular Zn(2+) activates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-inhibition.	Zinc	14-16	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	35-59
22930753-1	2012	Extracellular Zn(2+) activates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-inhibition.	Zinc	14-16	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	61-65
22930753-9	2012	Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516).	Zinc	34-36	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
22930753-9	2012	Our results suggest that external Zn(2+) regulates ENaC activity by binding to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory site within the finger subdomain involving His(193), His(200), and His(202) and (ii) a low-affinity Zn(2+) inhibitory site within the palm subdomain that includes His(88) and Asp(516).	Zinc	276-278	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
22898785-0	2012	Synergistic effect of ZnS outer layers and electrolyte methanol content on efficiency in TiO2/CdS/CdSe sensitized solar cells.	Zinc	22-25	CDP-diacylglycerol synthase 1	Homo sapiens	94-97
23089641-3	2012	Functional assay showed that Ca2+, Mg2+, and Zn2+ activate hPLSCR4 and mediate scrambling activity independent of the phospholipid head group.	Zinc	45-49	phospholipid scramblase 4	Homo sapiens	59-66
22819077-9	2012	Glycine substitution of the conserved amino acid residue Glu261 of APN-1, corresponding to Glu145 involved in coordinating Zn(2+) ions in the active site pocket of E. coli endonuclease IV, resulted in an inactive variant that lose the ability to rescue the DNA repair defects of S. cerevisiae apn1Deltaapn2Deltatpp1Delta mutant.	Zinc	123-125	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	67-72
22992540-2	2012	Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and Abeta with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of Abeta aggregation and toxicity.	Zinc	150-152	amyloid beta (A4) precursor protein	Mus musculus	59-84
22992540-2	2012	Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and Abeta with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of Abeta aggregation and toxicity.	Zinc	150-152	amyloid beta (A4) precursor protein	Mus musculus	95-100
23383499-5	2012	The proposed quantitative method was successfully applied with 0-0.50% error for the determination of Co2+ from Ni2+ in spiked samples of bauxite, soil and rock containing common cations such as Al3+, Fe2+, Ti4+, Zn2+, Mn2+, Cu2+, Cr6+, Mg2+ etc.	Zinc	213-217	complement C2	Homo sapiens	102-105
22879599-12	2012	This indicates that Asp(313), which was shown to modulate Zn(2+) binding, is an essential residue of the pH sensor of GPR39.	Zinc	58-64	G protein-coupled receptor 39	Homo sapiens	118-123
22825026-2	2012	Novel dimeric tetrahedral Zintl clusters [(eta(2)-E(4))Zn(eta(2)-E(4))](6-) with mixed site occupation (E = Si/Ge) were obtained through reaction with (C(6)H(6))(2)Zn in ammonia solutions and investigated by means of X-ray single crystal diffraction.	Zinc	55-57	ubiquitination factor E4A	Homo sapiens	50-54
22825026-2	2012	Novel dimeric tetrahedral Zintl clusters [(eta(2)-E(4))Zn(eta(2)-E(4))](6-) with mixed site occupation (E = Si/Ge) were obtained through reaction with (C(6)H(6))(2)Zn in ammonia solutions and investigated by means of X-ray single crystal diffraction.	Zinc	55-57	ubiquitination factor E4A	Homo sapiens	65-69
22621784-1	2012	Zinc (Zn) transporter 4 (ZnT4) plays a key role in mammary gland Zn metabolism.	Zinc	6-8	solute carrier family 30 (zinc transporter), member 4	Mus musculus	25-29
22621784-6	2012	ZnT4-mediated Zn import into the TGN directly contributed to labile Zn accumulation as ZnT4 overexpression increased FluoZin3 fluorescence.	Zinc	0-2	solute carrier family 30 (zinc transporter), member 4	Mus musculus	87-91
22621784-6	2012	ZnT4-mediated Zn import into the TGN directly contributed to labile Zn accumulation as ZnT4 overexpression increased FluoZin3 fluorescence.	Zinc	14-16	solute carrier family 30 (zinc transporter), member 4	Mus musculus	0-4
22621784-6	2012	ZnT4-mediated Zn import into the TGN directly contributed to labile Zn accumulation as ZnT4 overexpression increased FluoZin3 fluorescence.	Zinc	14-16	solute carrier family 30 (zinc transporter), member 4	Mus musculus	87-91
22621784-7	2012	Moreover, ZnT4 provided Zn for metallation of galactosyltransferase, a Zn-dependent protein localized within the TGN that is critical for milk secretion, and carbonic anhydrase VI, a Zn-dependent protein secreted from the TGN into milk.	Zinc	24-26	solute carrier family 30 (zinc transporter), member 4	Mus musculus	10-14
22621784-7	2012	Moreover, ZnT4 provided Zn for metallation of galactosyltransferase, a Zn-dependent protein localized within the TGN that is critical for milk secretion, and carbonic anhydrase VI, a Zn-dependent protein secreted from the TGN into milk.	Zinc	24-26	solute carrier family 30 (zinc transporter), member 4	Mus musculus	10-14
22520078-1	2012	Arabidopsis thaliana MTP1 is a vacuolar membrane Zn(2+)/H(+) antiporter of the cation diffusion facilitator family.	Zinc	49-51	zinc transporter	Arabidopsis thaliana	21-25
22520078-2	2012	Here we present a structure-function analysis of AtMTP1-mediated transport and its remarkable Zn(2+) selectivity by functional complementation tests of more than 50 mutant variants in metal-sensitive yeast strains.	Zinc	94-100	zinc transporter	Arabidopsis thaliana	49-55
22520078-4	2012	The Zn(2+)-binding sites of EcYiiP in the cytoplasmic C-terminus, and the pore formed by transmembrane helices TM2 and TM5, are conserved in AtMTP1.	Zinc	4-10	zinc transporter	Arabidopsis thaliana	141-147
22520078-5	2012	Although absent in EcYiiP, Cys31 and Cys36 in the extended N-terminal cytosolic domain of AtMTP1 are necessary for complementation of a Zn-sensitive yeast strain.	Zinc	136-138	zinc transporter	Arabidopsis thaliana	90-96
22520078-6	2012	On the cytosolic side of the active Zn(2+)-binding site inside the transmembrane pore, Ala substitution of either Asn258 in TM5 or Ser101 in TM2 non-selectively enhanced the metal tolerance conferred by AtMTP1.	Zinc	36-42	zinc transporter	Arabidopsis thaliana	203-209
22520078-7	2012	Modeling predicts that these residues obstruct the movement of cytosolic Zn(2+) into the intra-membrane Zn(2+)-binding site of AtMTP1.	Zinc	73-75	zinc transporter	Arabidopsis thaliana	127-133
22520078-7	2012	Modeling predicts that these residues obstruct the movement of cytosolic Zn(2+) into the intra-membrane Zn(2+)-binding site of AtMTP1.	Zinc	73-79	zinc transporter	Arabidopsis thaliana	127-133
22651379-7	2012	Additionally, both HL1 and HL2 exhibit an important selectivity for Cu(2+) over Zn(2+).	Zinc	80-82	intelectin 1	Homo sapiens	19-22
22560194-5	2012	In the present study, involvement of synaptic Zn(2+) in stress-induced attenuation of CA1 LTP was examined in hippocampal slices from young rats after exposure to tail suspension stress for 30s, which significantly increased serum corticosterone.	Zinc	46-48	carbonic anhydrase 1	Rattus norvegicus	86-89
22560194-6	2012	Stress-induced attenuation of CA1 LTP was ameliorated by administration of clioquinol, a membrane permeable zinc chelator, to rats prior to exposure to stress, implying that the reduction of synaptic Zn(2+) by clioquinol participates in this amelioration.	Zinc	200-202	carbonic anhydrase 1	Rattus norvegicus	30-33
22560194-7	2012	To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone.	Zinc	53-59	carbonic anhydrase 1	Rattus norvegicus	85-88
22560194-11	2012	The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress.	Zinc	81-87	carbonic anhydrase 1	Rattus norvegicus	158-161
22434504-8	2012	This difference in activity may result from binding of a second Zn(2+)  ion by a putative zinc finger in gp74 in addition to binding of a Zn(2+)  ion by the HNH motif.	Zinc	64-66	Gp74	Escherichia phage HK97	105-109
22434504-8	2012	This difference in activity may result from binding of a second Zn(2+)  ion by a putative zinc finger in gp74 in addition to binding of a Zn(2+)  ion by the HNH motif.	Zinc	138-140	Gp74	Escherichia phage HK97	105-109
23565341-7	2012	RESULTS: 1) sirtuin pathway inhibition or SIRT1 knockdown attenuated Zn2+-, STZ-, and cytokine-mediated toxicity and NAD+ loss in beta-cells, 2) SIRT1 overexpression potentiated these toxicities, 3) young SIRT1 beta-cell transgenic mice have improved glucose tolerance under basal conditions, but upon aging showed increased sensitivity to streptozotocin compared to SIRT1 +/- mice, and 4) SIRT1 +/- mice in an NOD background or exposed to streptozotocin trended toward reduced diabetic incidence and mortality compared to wildtype.	Zinc	69-73	sirtuin 1	Mus musculus	42-47
23565341-8	2012	CONCLUSIONS: These results have implicated SIRT1-mediated NAD+ loss in Zn2+, STZ, or cytokine toxicities of MIN6, and in NOD or streptozotocin T1DM animal models.	Zinc	71-75	sirtuin 1	Mus musculus	43-48
22625223-8	2012	CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.	Zinc	75-77	insulin like growth factor binding protein 3	Homo sapiens	28-35
22625223-8	2012	CONCLUSION: Serum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.	Zinc	110-112	insulin like growth factor binding protein 3	Homo sapiens	28-35
22441041-14	2012	These results suggest that SNARE proteins are necessary for the increased activity of KCC2 after Zn(2+) stimulation of mZnR/GPR39.	Zinc	97-103	solute carrier family 12 member 5	Rattus norvegicus	86-90
22529353-0	2012	Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.	Zinc	85-89	CD2 molecule	Homo sapiens	95-98
22068728-6	2012	Both shRNA-DMT1 and shRNA-hCTR1 cells had lower apical Fe uptake (a decrease of 51% and 41%, respectively), Cu uptake (a decrease of 25.8% and 38.5%, respectively), and Zn content (a decrease of 23.1% and 22.7%, respectively) compared to control cells.	Zinc	169-171	solute carrier family 31 member 1	Homo sapiens	26-31
22068728-7	2012	These results confirm that DMT1 is involved in active transport of Fe, Cu, and Zn although Zn showed a different relative capacity.	Zinc	79-81	solute carrier family 11 member 2	Homo sapiens	27-31
22357647-2	2012	These two Zn-dependent enzymes, produced by the Gram-positive bacterium Clostridium histolyticum, are related functionally to matrix metalloproteinases (MMPs) which, among other functions, degrade the extracellular matrix.	Zinc	10-12	matrix metallopeptidase 1	Homo sapiens	153-157
22101393-7	2012	Zn2+ is necessary for PC-PLC enzymatic activity; inhibition by D609 might be attributed to its Zn2+ chelation.	Zinc	0-4	heparan sulfate proteoglycan 2	Homo sapiens	25-28
22676822-6	2012	Significant increases in cell proliferation, ALP activity on day 7, and osteocalcin production on day 14 (P &lt; .05) were observed for Zn(2+)-containing HA-coated surfaces.	Zinc	136-142	bone gamma-carboxyglutamate protein 2	Mus musculus	72-83
22154800-10	2012	The neurosteroid-induced increase in LC3-II levels was inhibited by addition of the Zn(2+) chelator TPEN.	Zinc	84-86	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	37-40
21664410-5	2011	Human S100A3 is characterized by two disulphide bridges and a preformed Zn(2+)-pocket, and may transfer Ca(2+) ions to peptidylarginine deiminases after its citrullination-mediated tetramerization.	Zinc	72-78	S100 calcium binding protein A3	Homo sapiens	6-12
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Zinc	17-19	immunoglobulin lambda variable 7-43	Homo sapiens	51-59
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Zinc	17-19	immunoglobulin lambda variable 7-43	Homo sapiens	202-210
22253048-6	2011	Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake.	Zinc	227-229	solute carrier family 39 member 1	Homo sapiens	36-41
22253048-6	2011	Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake.	Zinc	227-229	solute carrier family 39 member 1	Homo sapiens	169-173
21873044-0	2011	Immobilization of rat brain acetylcholinesterase on ZnS and poly(indole-5-carboxylic acid) modified Au electrode for detection of organophosphorus insecticides.	Zinc	52-55	acetylcholinesterase	Rattus norvegicus	28-48
20878652-0	2011	Aqueous synthesis of CdTe/CdS/ZnS quantum dots and their optical and chemical properties.	Zinc	30-33	CDP-diacylglycerol synthase 1	Homo sapiens	26-29
20878652-4	2011	The characterization of high-resolution transmission electron microscopy (HRTEM), X-ray powder diffraction (XRD) and fluorescence correlation spectroscopy (FCS) showed that the CdTe/CdS/ZnS QDs had good monodispersity and crystal structure.	Zinc	186-189	CDP-diacylglycerol synthase 1	Homo sapiens	182-185
20878652-5	2011	The fluorescence life time spectra demonstrated that CdTe/CdS/ZnS QDs had a longer lifetime in contrast to fluorescent dyes and CdTe QDs.	Zinc	62-65	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
20878652-8	2011	More importantly, our method was cost-effective, and was very suitable for large-scale synthesis of CdTe/CdS/ZnS QDs for future applications.	Zinc	109-112	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
20953845-10	2011	Nevertheless, dietary Zn influenced the growth, bone metabolism, and expression of IGF-I and ALP in male growing rats.	Zinc	22-24	insulin-like growth factor 1	Rattus norvegicus	83-88
21806983-4	2011	The administration of Zn decreased the activities of bone tartrate-resistant acid phosphatase (TRAP) and cathepsin K, without affecting the serum osteocalcin level.	Zinc	22-24	cathepsin K	Rattus norvegicus	105-116
21777051-1	2011	The study was undertaken to investigate the effect of zinc (Zn) on glutathione S-transferase (GST) and superoxide dismutases (SOD) activities and on the expressions of cytosolic Cu, Zn-SOD (SOD1), mitochondrial Mn-SOD (SOD2), gamma-glutamyl cysteine synthetase (gamma-GCS) and heme oxygenase-1 (HO-1) in the nigrostriatal tissue of rats.	Zinc	60-62	hematopoietic prostaglandin D synthase	Rattus norvegicus	94-97
21784112-1	2011	In this study, alpha-synuclein was treated in vitro with salicylaldehyde (SA), lysine (lys) and M(n+) (Cu(2+) or Zn(2+)) in various ratios.	Zinc	113-115	synuclein alpha	Homo sapiens	15-30
21866963-3	2011	The conjugation of the antithrombin or anti-ATP aptamers to CdSe/ZnS semiconductor quantum dots (QDs) allowed the detection of thrombin or ATP through the luminescence of the QDs that is powered by a chemiluminescence resonance energy-transfer (CRET) process stimulated by the hemin/G-quadruplex/thrombin complex or the hemin/G-quadruplex/ATP nanostructure, in the presence of luminol/H(2)O(2).	Zinc	65-68	serpin family C member 1	Homo sapiens	23-35
21852741-0	2011	Phosphine-free synthesis of high-quality reverse type-I ZnSe/CdSe core with CdS/Cd(x)Zn(1 - x)S/ZnS multishell nanocrystals and their application for detection of human hepatitis B surface antigen.	Zinc	56-58	CDP-diacylglycerol synthase 1	Homo sapiens	61-64
21852741-2	2011	By this low-cost, "green" synthesis route, more than 10 g of high-quality ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS NCs were synthesized in a large scale synthesis.	Zinc	74-76	CDP-diacylglycerol synthase 1	Homo sapiens	79-82
21852741-2	2011	By this low-cost, "green" synthesis route, more than 10 g of high-quality ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS NCs were synthesized in a large scale synthesis.	Zinc	74-77	CDP-diacylglycerol synthase 1	Homo sapiens	79-82
21852741-5	2011	The as-prepared water dispersible ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS core/multishell NCs not only have high fluorescence QYs but also are extremely stable in various physiological conditions.	Zinc	34-37	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
21852741-7	2011	The result showed that such ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS core/multishell NCs were excellent fluorescent labels to detect HBsAg.	Zinc	28-30	CDP-diacylglycerol synthase 1	Homo sapiens	33-36
21852741-7	2011	The result showed that such ZnSe/CdSe/CdS/Cd(x)Zn(1 - x)S/ZnS core/multishell NCs were excellent fluorescent labels to detect HBsAg.	Zinc	28-31	CDP-diacylglycerol synthase 1	Homo sapiens	33-36
20588324-6	2011	After accounting for measurement uncertainties, 11 elements (Ca, Cs, Cu, Fe, K, Mg, Na, P, Rb, S, and Zn) had lower 95% ULs&gt;0 ng/spot with estimated concentrations ranging from 0.05 to &gt;50,000 ng/spot in &gt;=50% of NBS samples in both correction methods.	Zinc	102-104	nibrin	Homo sapiens	222-225
21377473-8	2011	We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3.	Zinc	56-58	S100 calcium binding protein A3	Homo sapiens	128-134
21310258-3	2011	Detailed studies have determined that a number of bacterial Glyoxalase I enzymes are maximally activated by Ni(2+) and Co(2+) ions, but are inactive in the presence of Zn(2+).	Zinc	168-170	glyoxalase I	Homo sapiens	60-72
21310258-4	2011	This is in contrast to the Glyoxalase I enzyme from humans, which is catalytically active with Zn(2+) as well as a number of other metal ions.	Zinc	95-98	glyoxalase I	Homo sapiens	27-39
21245412-9	2011	Immunohistochemical analysis of carcinomas showed that Zn supplementation caused a shift to a less proliferative/aggressive cancer phenotype by reducing cell proliferation, stimulating apoptosis and decreasing expression of the key tumor markers cyclin D1, p53 and COX-2.	Zinc	55-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	257-260
21256016-6	2011	Four cysteines coordinate Zn(2+) in the ZF, which ensures that I-TevI cleaves its DNA substrate at a fixed distance, 23-25 nucleotides upstream of the intron insertion site.	Zinc	26-28	GIY-YIG nuclease family protein	Escherichia phage T4	63-69
21256016-7	2011	We show that the fidelity of I-TevI cleavage is controlled by redox-responsive Zn(2+) cycling.	Zinc	79-81	GIY-YIG nuclease family protein	Escherichia phage T4	29-35
21209194-5	2011	When isolated by blockade of NMDA receptors and voltage-gated calcium channels, the absence of both transporters slowed passive Zn uptake into CA1 neurons measured with intracellular fluorescent Zn dyes.	Zinc	128-130	carbonic anhydrase 1	Mus musculus	143-146
21209194-5	2011	When isolated by blockade of NMDA receptors and voltage-gated calcium channels, the absence of both transporters slowed passive Zn uptake into CA1 neurons measured with intracellular fluorescent Zn dyes.	Zinc	195-197	carbonic anhydrase 1	Mus musculus	143-146
21239856-1	2011	The amyloid-beta protein (Abeta) is a metalloprotein with affinity for the metal ions zinc (Zn), copper (Cu), and iron (Fe), which are found in high concentrations in the plaques of Alzheimer"s disease (AD).	Zinc	92-94	amyloid beta (A4) precursor protein	Mus musculus	26-31
21179242-6	2010	In vivo, Zn(2+) is normally present in the inner and outer segments (associated with rhodopsin), Bruch"s membrane and sclera (elastin), RPE, and the outer plexiform layer of the eye (synaptic).	Zinc	9-11	rhodopsin	Rattus norvegicus	85-94
21179242-6	2010	In vivo, Zn(2+) is normally present in the inner and outer segments (associated with rhodopsin), Bruch"s membrane and sclera (elastin), RPE, and the outer plexiform layer of the eye (synaptic).	Zinc	9-11	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	136-139
21179242-13	2010	Exposure to 18 kLux of cool white fluorescent light for 1 h induced a large increase in Zn(2+) staining 4-14 h later, particularly in the superior outer nuclear layer and RPE of dark-maintained Sprague Dawley albino rats; 4 h of light was required to induce similar damage in cyclic light-maintained rats.	Zinc	88-94	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	171-174
21179242-17	2010	These results suggest that cyclic light maintenance, Zn(2+) chelation, pyruvate, and nicotinamide promote RPE and photoreceptor survival after injury and could be effective for various forms of retinal neurodegeneration.	Zinc	53-55	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	106-109
20705137-7	2010	Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method.	Zinc	51-53	solute carrier family 39 member 1	Homo sapiens	187-192
20705137-7	2010	Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method.	Zinc	171-173	solute carrier family 39 member 1	Homo sapiens	187-192
20705137-7	2010	Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method.	Zinc	171-173	solute carrier family 39 member 1	Homo sapiens	187-192
21106837-9	2010	Furthermore, mutating the Zn(2+)-binding site within T1 markedly decreases channel axonal targeting and forward trafficking, likely through disrupting T1 tetramerization and hence eliminating the binding to KIF5 tail.	Zinc	26-32	kinesin family member 5A	Mus musculus	207-211
20378931-8	2010	Here, we used flow cytometry and surface plasmon resonance to study SgI regarding its association with spermatozoa and the interaction dependency on Zn(2+).	Zinc	149-151	semenogelin 1	Homo sapiens	68-71
20378931-9	2010	The concentration of Zn(2+) in seminal plasma is approximately 100 times higher than in blood plasma, and the metal ion is known to change the structure of SgI.	Zinc	21-23	semenogelin 1	Homo sapiens	156-159
20378931-11	2010	In solution, SgI bound to spermatozoa in a non-Zn(2+)-dependent way, whereas immobilized SgI interacts with spermatozoa only in the presence of Zn(2+).	Zinc	144-146	semenogelin 1	Homo sapiens	89-92
20637810-4	2010	In the present study, we used the electrophysiology method to investigate the effects of Zn(2+) on the excitability of hippocampus CA1 region.	Zinc	89-95	carbonic anhydrase 1	Rattus norvegicus	131-134
20637810-5	2010	Our results have demonstrated that the Zn(2+) activates the Wistar rat hippocampal CA1 region network by significantly enhancing the spike rate of the spontaneous firing.	Zinc	39-41	carbonic anhydrase 1	Rattus norvegicus	83-86
20637810-9	2010	The present results, in combination with other works, suggest that Zn(2+) can influence neuronal excitability, intrinsic membrane excitability and synaptic transmission in the hippocampus CA1 neurons by multiple mechanisms.	Zinc	67-73	carbonic anhydrase 1	Rattus norvegicus	188-191
21368864-7	2010	Finally, we found that Zn(2+) supplementation greatly increases the levels of brain-derived neurotrophic factor (BDNF) of treated 3xTg-AD mice.	Zinc	23-25	brain derived neurotrophic factor	Mus musculus	78-111
21368864-7	2010	Finally, we found that Zn(2+) supplementation greatly increases the levels of brain-derived neurotrophic factor (BDNF) of treated 3xTg-AD mice.	Zinc	23-25	brain derived neurotrophic factor	Mus musculus	113-117
20647347-8	2010	The transport pathway mediated by PCR2 does not seem to overlap with that mediated by the described Zn translocators (HMA2 and HMA4) since the growth of pcr2 hma4 double and pcr2 hma2 hma4 triple loss-of-function mutants was more severely inhibited than the individual single knockout mutants, both under conditions of excess or deficient Zn.	Zinc	100-102	heavy metal atpase 2	Arabidopsis thaliana	118-122
20223829-6	2010	S-Glutathionylation exposed more hydrophobic regions in Zn(2+)-bound A9 but did not alter Zn(2+) binding affinity.	Zinc	56-58	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	69-71
20380637-7	2010	Besides direct interaction of Ti(2+) with DNA, induction of the MT1 family of metallothionein genes and downregulation of cellular Zn(2+) uptake in response to titanocene C pointed to disturbed Zn(2+) homeostasis, which triggers cell cycle arrest and apoptosis due to defective transcription factors and metalloenzymes.	Zinc	194-196	metallothionein 1I, pseudogene	Homo sapiens	64-67
20129672-9	2010	It is proposed that the inhibitory effect of the ions (Co(2+), Mn(2+), and Zn(2+)) or selenite on hAS3MT activity might be via the interactions of them with free Cys residues in hAS3MT to form inactive protein adducts.	Zinc	75-81	PDS5 cohesin associated factor B	Homo sapiens	98-102
20226931-4	2010	The new Ag/Zn/PEG sol-gel fiber is simple to prepare, low cost, robust, has high thermal stability and long lifetime, up to 359 extractions.	Zinc	11-13	progestagen associated endometrial protein	Homo sapiens	14-17
20226931-7	2010	Under their optimum conditions, Ag/Zn/PEG sol-gel fiber showed the highest sensitivity and the lowest detection limit at 0.28+/-0.01 ng mL(-1).	Zinc	35-37	progestagen associated endometrial protein	Homo sapiens	38-41
20165791-2	2010	PDI-1 exhibited high selectivity toward Ni(2+) in the presence of various other metal cations including Zn(2+), Cd(2+) and Cu(2+) which were expected to interfere significantly.	Zinc	104-107	peptidyl arginine deiminase 1	Homo sapiens	0-5
20811517-5	2010	Specifically, levels of SOD, Se and Zn decreased by 67%, 30% and 35%; 70%, 52% and 41%; 81%, 58% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and &gt; 20 ng/ml, respectively.	Zinc	36-38	kallikrein related peptidase 3	Homo sapiens	123-126
19946718-1	2010	Zn(2+) exerts insulin-mimetic and antidiabetic effects in rodent models of insulin resistance, and activates extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), key components of the insulin signaling pathway.	Zinc	0-2	protein tyrosine kinase 2 beta	Homo sapiens	187-190
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	insulin receptor	Cricetulus griseus	109-125
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	insulin receptor	Cricetulus griseus	127-129
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	insulin-like growth factor 1 receptor	Cricetulus griseus	146-183
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	insulin-like growth factor 1 receptor	Cricetulus griseus	185-191
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	epidermal growth factor receptor	Cricetulus griseus	197-229
19946718-2	2010	Zn(2+)-induced signaling has been shown to be associated with an increase in the tyrosine phosphorylation of insulin receptor (IR), as well as of insulin-like growth factor 1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) in several cell types.	Zinc	0-2	epidermal growth factor receptor	Cricetulus griseus	231-235
19946718-4	2010	Therefore, using a series of pharmacological inhibitors and genetically engineered cells, we have investigated the roles of various R-PTKs in Zn(2+)-induced ERK1/2 and PKB phosphorylation.	Zinc	142-148	protein tyrosine kinase 2 beta	Homo sapiens	168-171
19946718-6	2010	On the other hand, both of these inhibitors were able to attenuate Zn(2+)-induced phosphorylation of ERK1/2 and PKB in A10 vascular smooth muscle cells.	Zinc	67-73	protein tyrosine kinase 2 beta	Homo sapiens	112-115
19946718-7	2010	In addition, in CHO cells overexpressing tyrosine kinase deficient IR, Zn(2+) was still able to induce the phosphorylation of these two signaling molecules, whereas the insulin effect was significantly attenuated.	Zinc	71-77	insulin receptor	Cricetulus griseus	67-69
19946718-9	2010	Also, Zn(2+)-induced responses in CHO-HIR cells were not associated with an increase in the tyrosine phosphorylation of the IR beta-subunit and insulin receptor substrate 1 in CHO-HIR cells.	Zinc	6-12	insulin receptor	Cricetulus griseus	39-41
19946718-10	2010	Taken together, these data suggest that distinct R-PTKs mediate Zn(2+)-evoked ERK1/2 and PKB phosphorylation in a cell-specific manner.	Zinc	64-70	protein tyrosine kinase 2 beta	Homo sapiens	89-92
19369054-6	2010	Diabetes-induced renal oxidative damage, inflammation and up-regulated expression of profibrosis mediator connective tissue growth factor (CTGF) were also markedly attenuated by Zn supplementation, along with significant increases in Zn levels concomitant with MT expression in renal tubular cells.	Zinc	178-180	cellular communication network factor 2	Rattus norvegicus	106-137
19369054-6	2010	Diabetes-induced renal oxidative damage, inflammation and up-regulated expression of profibrosis mediator connective tissue growth factor (CTGF) were also markedly attenuated by Zn supplementation, along with significant increases in Zn levels concomitant with MT expression in renal tubular cells.	Zinc	178-180	cellular communication network factor 2	Rattus norvegicus	139-143
19369054-8	2010	Pretreatment of HK11 cells with Zn or cadmium induced MT expression and also significantly suppressed HG-induced CTGF expression.	Zinc	32-34	cellular communication network factor 2	Rattus norvegicus	113-117
19369054-9	2010	These results provide the first evidence for Zn supplementation to attenuate diabetes-induced renal pathological changes, likely through prevention of hyperglycemia-induced CTGF expression by Zn-induced MT in renal tubular cells.	Zinc	45-47	cellular communication network factor 2	Rattus norvegicus	173-177
19369054-9	2010	These results provide the first evidence for Zn supplementation to attenuate diabetes-induced renal pathological changes, likely through prevention of hyperglycemia-induced CTGF expression by Zn-induced MT in renal tubular cells.	Zinc	192-194	cellular communication network factor 2	Rattus norvegicus	173-177
19966058-7	2010	The effect of morphine on Zn(2+) release was also abolished by KT5823, a specific inhibitor of protein kinase G (PKG).	Zinc	26-32	protein kinase cGMP-dependent 1	Homo sapiens	95-111
19966058-7	2010	The effect of morphine on Zn(2+) release was also abolished by KT5823, a specific inhibitor of protein kinase G (PKG).	Zinc	26-32	protein kinase cGMP-dependent 1	Homo sapiens	113-116
19896525-5	2010	Along with the phen study, we also found that Zn(2+), Fe(2+) and Cu(2+) increased Cyp1a1 mRNA and protein stability.	Zinc	46-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
19896525-7	2010	In addition, Zn(2+) and Fe(2+) highly neutralized phen"s suppression of Cyp1a1 protein expression, but they only slightly neutralized phen"s promotion of mRNA stability and suppression of cell viability, and had no effect on phen"s suppression of promoter activity.	Zinc	13-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
20333873-10	2009	CONCLUSION: Serum IGF-I and IGFBP-3 levels were decreased in children with Zn deficiency, and were increased after Zn supplementation.	Zinc	75-77	insulin like growth factor binding protein 3	Homo sapiens	28-35
19780525-4	2009	In this work, we used a combined potentiometric, NMR, and electrospray ionization mass spectrometry (ESI-MS) approach to study the zinc(II) binding to a new polyethylene glycol (PEG)-conjugated peptide fragment encompassing the 1-16 amino acid sequence of Abeta (Abeta(1-16)PEG).	Zinc	131-139	progestagen associated endometrial protein	Homo sapiens	178-181
19780525-4	2009	In this work, we used a combined potentiometric, NMR, and electrospray ionization mass spectrometry (ESI-MS) approach to study the zinc(II) binding to a new polyethylene glycol (PEG)-conjugated peptide fragment encompassing the 1-16 amino acid sequence of Abeta (Abeta(1-16)PEG).	Zinc	131-139	progestagen associated endometrial protein	Homo sapiens	263-277
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Zinc	53-57	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Zinc	100-104	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-7	2009	The values of I(50) for NEIL1 inhibition were 7 microM for Cd2+, 16 microM for Zn2+, and 400 microM for Cu2+.	Zinc	79-83	nei like DNA glycosylase 1	Homo sapiens	24-29
19916941-8	2009	The inhibition of NEIL1 by Cd2+, Zn2+, and Cu2+ was at least partly due to the formation of metal-DNA complexes.	Zinc	33-37	nei like DNA glycosylase 1	Homo sapiens	18-23
19698999-5	2009	Relatively weak inhibition by TTX (30+/-3% at 500nM) and sensitivity to 100microM Zn(2+) suggested that this current was predominantly mediated by the cardiac sodium channel isoform Na(V)1.5.	Zinc	82-84	immunoglobulin lambda variable 2-18	Homo sapiens	174-190
19756305-2	2009	Here, we report that erythrocytes (ERYs) obtained from type 2 diabetic rats display an apparent resistance to Zn(2+)-activated C-peptide.	Zinc	110-116	insulin 2	Rattus norvegicus	127-136
19756305-3	2009	Thus, the aims of this study were to demonstrate that Zn(2+)-activated C-peptide exerts potentially beneficial effects on healthy ERYs and that these same effects on type 2 diabetic ERYs are enhanced in the presence of metformin.	Zinc	54-60	insulin 2	Rattus norvegicus	71-80
19756305-4	2009	Incubation of ERYs (obtained from type 2 diabetic BBZDR/Wor-rats) with Zn(2+)-activated C-peptide followed by chemiluminescence measurements of ATP resulted in a 31.2 +/- 4.0% increase in ATP release from these ERYs compared to a 78.4 +/- 4.9% increase from control ERYs.	Zinc	71-73	insulin 2	Rattus norvegicus	88-97
19756305-7	2009	Phosphatidylserine (PS) externalization and metformin sensitization of Zn(2+)-activated C-peptide were examined spectrofluorometrically by measuring the binding of FITC-labeled annexin to PS.	Zinc	71-77	insulin 2	Rattus norvegicus	88-97
19756305-8	2009	The incubation of diabetic ERYs with metformin prior to the addition of Zn(2+)-activated C-peptide resulted in values that were statistically equivalent to those of controls.	Zinc	72-74	insulin 2	Rattus norvegicus	89-98
19756305-9	2009	Summarily, data obtained here demonstrate an apparent resistance to Zn(2+)-activated C-peptide by the ERY that is corrected by metformin.	Zinc	68-74	insulin 2	Rattus norvegicus	85-94
19719190-0	2009	Ratiometric Zn2+ fluorescent sensor and new approach for sensing Cd2+ by ratiometric displacement.	Zinc	12-16	CD2 molecule	Homo sapiens	65-68
19458277-7	2009	Although total mammary gland Zn concentration was not altered, Zip3-null mice also had altered mammary tissue architecture, increased number of apoptotic cells, and reduced mammary gland weight implicating subtle changes in Zip3-mediated intracellular Zn pools in apoptosis regulation.	Zinc	252-254	solute carrier family 39 (zinc transporter), member 3	Mus musculus	63-67
19458277-7	2009	Although total mammary gland Zn concentration was not altered, Zip3-null mice also had altered mammary tissue architecture, increased number of apoptotic cells, and reduced mammary gland weight implicating subtle changes in Zip3-mediated intracellular Zn pools in apoptosis regulation.	Zinc	252-254	solute carrier family 39 (zinc transporter), member 3	Mus musculus	224-228
19458277-8	2009	Taken together, our data indicate that Zip3 does not participate in the acquisition of Zn from maternal circulation for secretion into milk but, in contrast, primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool, thus regulating cellular function.	Zinc	223-225	solute carrier family 39 (zinc transporter), member 3	Mus musculus	39-43
19381799-2	2009	This study investigated the effect of chronic high intake of dietary Zn or Cu on brain metal levels and the accumulation and solubility of Abeta in vivo, using a transgenic mouse model that over expresses the C-terminal containing Abeta fragment of human amyloid precursor protein but does not develop amyloid deposits.	Zinc	69-71	amyloid beta (A4) precursor protein	Mus musculus	231-236
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Zinc	85-91	myoglobin	Homo sapiens	31-40
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Zinc	85-91	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Zinc	85-91	myoglobin	Homo sapiens	175-184
19798981-4	2009	It was found that heme-iron of myoglobin directly interacted with additional Cu(II), Zn(II) and Co(II), these metal ions could drag iron ion out from heme prosthetic group of myoglobin, and subsequently myoglobin became myoglobin derivatives lacking iron ion.	Zinc	85-91	myoglobin	Homo sapiens	175-184
19288494-8	2009	Expression of zinc transporter-1 (ZnT-1), previously shown to regulate Zn(2+) influx, increased following prolonged application of zinc or cadmium to the explants and prevented clusterin up-regulation by subsequent exposure to these ions.	Zinc	71-77	clusterin	Mus musculus	177-186
19288494-9	2009	Inhibition of the MAPK and PI3K pathways reduced the up-regulation of clusterin following the intracellular rise of Zn(2+) or Cd(2+).	Zinc	116-118	clusterin	Mus musculus	70-79
19288494-10	2009	Neutralization of secreted clusterin by an antibody or attenuation of clusterin up-regulation by inhibition of Zn(2+) permeation via the LTCC, reduced cell death in cultured seminiferous tubule cells.	Zinc	111-113	clusterin	Mus musculus	70-79
19288494-11	2009	Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate.	Zinc	42-48	clusterin	Mus musculus	102-111
19561609-4	2009	In the complex structure, a critical loop from HHIP binds the pseudo active site groove of SHH and directly coordinates its Zn2+ cation.	Zinc	124-128	sonic hedgehog signaling molecule	Homo sapiens	91-94
19460865-5	2009	Our results highlight the importance of the Spt4 Zn2+-binding residues--Cys12, Cys15, Cys29, and Asp32--and of Ser57, a conserved constituent of the Spt4-Spt5 interface.	Zinc	49-53	transcription elongation factor SPT4	Saccharomyces cerevisiae S288C	44-48
19460865-5	2009	Our results highlight the importance of the Spt4 Zn2+-binding residues--Cys12, Cys15, Cys29, and Asp32--and of Ser57, a conserved constituent of the Spt4-Spt5 interface.	Zinc	49-53	transcription elongation factor SPT5	Saccharomyces cerevisiae S288C	154-158
19530781-0	2009	The nature of interactions between clusters of Mg and Zn with HCN from symmetry-adapted perturbation theory based of DFT.	Zinc	54-56	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	62-65
19254786-6	2009	Growth plate MT-III expression increased in MT(-/-) mice fed the adequate Zn diet, whereas metaphyseal MT-III was significantly upregulated in MT(-/-) mice fed Zn-L diet, possibly as a compensatory mechanism or exacerbating effects of Zn limitation.	Zinc	160-162	metallothionein 3	Mus musculus	103-109
19254786-6	2009	Growth plate MT-III expression increased in MT(-/-) mice fed the adequate Zn diet, whereas metaphyseal MT-III was significantly upregulated in MT(-/-) mice fed Zn-L diet, possibly as a compensatory mechanism or exacerbating effects of Zn limitation.	Zinc	160-162	metallothionein 3	Mus musculus	103-109
19254786-7	2009	Consistent with the increased osteoclast numbers, a higher ratio of RANKL/OPG gene expression was found in bone of mutant mice fed lower Zn diets.	Zinc	137-139	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	68-73
19328518-6	2009	Compared with controls, NADH oxidase and peroxidase (POD) activity increased in leaves and roots of plants under high Zn, but superoxide dismutase (SOD), catalase and ascorbate peroxidase activities decreased.	Zinc	118-120	peroxidase A2	Brassica napus	53-56
19207208-2	2009	It exhibits amino acid sequence similarity to two other Zn(II) transporters, AtHMA2 and AtHMA4, and contains poly-His motifs that are commonly found in Zn(II)-binding proteins, but lacks some amino acids that are typical for this class of transporters.	Zinc	56-62	heavy metal atpase 2	Arabidopsis thaliana	77-83
19240037-4	2009	Here, we demonstrate that plasmin can cleave the native NR2A amino-terminal domain (NR2A(ATD)), removing the functional high affinity Zn(2+) binding site.	Zinc	134-136	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	56-60
19340922-0	2009	Evidence for presence of Zn+2-binding site in acetylcholinesterase.	Zinc	25-29	acetylcholinesterase	Capra hircus	46-66
19340922-1	2009	The purified electric eel acetylcholinesterase (AChE) was able to bind to the Zn+2-chelate-Sepharose affinity column only on treatment with EDTA.	Zinc	78-80	acetylcholinesterase	Capra hircus	26-46
19340922-1	2009	The purified electric eel acetylcholinesterase (AChE) was able to bind to the Zn+2-chelate-Sepharose affinity column only on treatment with EDTA.	Zinc	78-80	acetylcholinesterase	Capra hircus	48-52
19340922-6	2009	These results confirm the presence of Zn+2- binding site on AChE and further removal of metal from binding site with chelators resulted in loss of its catalytic function.	Zinc	38-42	acetylcholinesterase	Capra hircus	60-64
18658230-0	2008	Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition.	Zinc	60-64	chloride voltage-gated channel 4	Homo sapiens	18-23
18658230-6	2008	Here, we record currents from human ClC-4 (hClC-4) expressed in Xenopus oocytes, and find that Zn(2+) inhibits these currents, with an apparent affinity of approximately 50 microM.	Zinc	95-101	chloride voltage-gated channel 4	Homo sapiens	36-41
18658230-6	2008	Here, we record currents from human ClC-4 (hClC-4) expressed in Xenopus oocytes, and find that Zn(2+) inhibits these currents, with an apparent affinity of approximately 50 microM.	Zinc	95-101	chloride voltage-gated channel 4	Homo sapiens	43-49
18658230-8	2008	In contrast, the effect of Zn(2+) on the ClC-0 channel, Zn(2+)-mediated inhibition of hClC-4 is minimally voltage-dependent, suggesting an extracellular binding site for the ion.	Zinc	27-29	chloride voltage-gated channel 4	Homo sapiens	86-92
18658230-8	2008	In contrast, the effect of Zn(2+) on the ClC-0 channel, Zn(2+)-mediated inhibition of hClC-4 is minimally voltage-dependent, suggesting an extracellular binding site for the ion.	Zinc	27-33	chloride voltage-gated channel 4	Homo sapiens	86-92
18658230-11	2008	Manipulations that alter transport properties of hClC-4, varying permeant ions as well as mutating the "gating glutamate", dramatically affect Zn(2+) inhibition, suggesting the involvement of a heretofore unexplored part of the protein in the transport process.	Zinc	143-145	chloride voltage-gated channel 4	Homo sapiens	49-55
18755683-3	2008	Both PMI1 and PMI2 were inhibited by incubation with EDTA, Zn(2+), Cd(2+), and L-ascorbic acid (AsA).	Zinc	59-61	PLASTID MOVEMENT IMPAIRED protein (DUF827)	Arabidopsis thaliana	14-18
18945899-7	2008	Zn PC exhibited the characteristic features of ischemic PC, including caspase-3 activation, PARP-1 cleavage, and HSP70 induction, all of which are crucial for subsequent neuroprotection against NMDA or zinc toxicity.	Zinc	0-2	poly (ADP-ribose) polymerase 1	Rattus norvegicus	92-98
18945899-7	2008	Zn PC exhibited the characteristic features of ischemic PC, including caspase-3 activation, PARP-1 cleavage, and HSP70 induction, all of which are crucial for subsequent neuroprotection against NMDA or zinc toxicity.	Zinc	0-2	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	113-118
18795802-7	2008	It was also seen that wild-type PMP22 binds Zn(II) and Cu(II) with micromolar affinity, a property that may be important to the stability and function of this protein.	Zinc	44-50	peripheral myelin protein 22	Homo sapiens	32-37
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	aminoacylase 1	Sus scrofa	142-146
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	alpha-1-acid glycoprotein	Sus scrofa	148-152
18799003-12	2008	Relative hepatic GLO1 (P &lt; 0.0007), PRDX4 (P &lt; 0.009) and ACY1 (P &lt; 0.01) mRNA abundances were confirmed to be greater in pigs fed 1,000 (n = 8) and 2,000 (n = 8) mg Zn/kg than in pigs fed 150 (n = 7) mg Zn/kg.	Zinc	175-177	aminoacylase 1	Sus scrofa	64-68
18799003-12	2008	Relative hepatic GLO1 (P &lt; 0.0007), PRDX4 (P &lt; 0.009) and ACY1 (P &lt; 0.01) mRNA abundances were confirmed to be greater in pigs fed 1,000 (n = 8) and 2,000 (n = 8) mg Zn/kg than in pigs fed 150 (n = 7) mg Zn/kg.	Zinc	213-215	aminoacylase 1	Sus scrofa	64-68
18588663-5	2008	RESULTS: Constitutive expression of the stronger interactor, Dpy-30L1 (CG6444), in transgenic flies inhibits MTF-1 activity and results in elevated sensitivity to Cd(II) and Zn(II), an effect that could be rescued by co-overexpression of dMTF-1.	Zinc	174-180	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	109-114
18588663-5	2008	RESULTS: Constitutive expression of the stronger interactor, Dpy-30L1 (CG6444), in transgenic flies inhibits MTF-1 activity and results in elevated sensitivity to Cd(II) and Zn(II), an effect that could be rescued by co-overexpression of dMTF-1.	Zinc	174-180	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	238-244
18411209-1	2008	Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd.	Zinc	131-133	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	24-29
18411209-1	2008	Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd.	Zinc	131-133	Metal response element-binding Transcription Factor-1	Drosophila melanogaster	31-37
17706324-11	2008	Although none of the mutations that we have tested abolished the block by Pb2+, our results indicate that the action of this toxic metal on NR channels is more dependent on the receptor composition than previously thought, because Zn2+ is able to displace Pb2+ from its binding site in epsilon1-containing channels, but not in epsilon2-containing channels.	Zinc	231-235	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	140-142
17979276-2	2007	The reaction was found to be catalyzed by both NiBr2(PPh3)2/Zn or PdCl2(PhCN)2 to yield complex heterocycles in good to moderate yields.	Zinc	60-62	protein phosphatase 4 catalytic subunit	Homo sapiens	53-57
17881000-8	2007	Modeling studies show that in the absence of bound leupeptin, Zn2+ is likely further coordinated by the imidazolyl side-chain of the catalytic His57 which can, similar to equivalent His57 imidazole groups in the related rat kallikrein proteinase tonin and in an engineered metal-binding rat trypsin, rotate out of its triad position to provide the third co-ordination site of the bound Zn2+, rendering Zn2+-bound hK5 inactive.	Zinc	62-66	keratin 5	Homo sapiens	413-416
17881000-9	2007	In solution, this mode of binding likely occurs in the presence of free and substrate saturated hK5, as kinetic analyses of Zn2+ inhibition indicate a non-competitive mechanism.	Zinc	124-128	keratin 5	Homo sapiens	96-99
17881000-12	2007	The His96-99-57 triad is thus suggested to be responsible for the Zn2+-mediated inhibition of hK5 catalysis.	Zinc	66-70	keratin 5	Homo sapiens	94-97
17918829-3	2007	Treatment of 2 with Na[BArF] results in the salt [{THF.Ga(DDP)}Zn(THF)(mu-Cl)]2[BArF]2 (3), with two Cl atoms bridging the Zn centers.	Zinc	63-65	translocase of inner mitochondrial membrane 8A	Homo sapiens	55-62
17869271-4	2007	Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5.	Zinc	88-90	cullin 5	Homo sapiens	159-163
17565998-4	2007	We now present evidence, by means of direct biochemical assays, that Zn2+ is imported through the Ca2+ uniporter and directly targets major enzymes of energy production (lipoamide dehydrogenase) and antioxidant defense (thioredoxin reductase and glutathione reductase).	Zinc	69-73	peroxiredoxin 5	Homo sapiens	220-241
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	217-223
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	217-223
17670971-3	2007	Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo.	Zinc	143-147	immunoglobulin lambda variable 7-43	Homo sapiens	202-210
17670971-3	2007	Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relieving tonic channel inhibition, enhancing Ca(v)3.2 currents, and lowering the threshold for nociceptor excitability in vitro and in vivo.	Zinc	143-147	immunoglobulin lambda variable 7-43	Homo sapiens	274-282
17592591-4	2007	The values of the stability constant of TTDA-mono and bis(amide) complex are significantly lower than those of TTDA and DTPA, but the selectivity constants of these ligands for Gd(III) over Zn(II) and Cu(II) are slightly higher than those of TTDA and DTPA.	Zinc	190-192	general transcription factor IIH subunit 5	Homo sapiens	40-44
17589793-2	2007	Semenogelin molecules initiate their own destruction by chelating Zn(2+) that normally would completely inhibit the proteolytic activity of KLK3.	Zinc	66-68	kallikrein related peptidase 3	Homo sapiens	140-144
17490605-2	2007	With guanidinium chloride, the stability order is myoglobin&gt;Zn-pheophorbide-myoglobin&gt;Zn-bacteriopheophorbide-myoglobin approximately apo-myoglobin.	Zinc	63-65	myoglobin	Homo sapiens	50-59
17490605-2	2007	With guanidinium chloride, the stability order is myoglobin&gt;Zn-pheophorbide-myoglobin&gt;Zn-bacteriopheophorbide-myoglobin approximately apo-myoglobin.	Zinc	63-65	myoglobin	Homo sapiens	79-88
17490605-2	2007	With guanidinium chloride, the stability order is myoglobin&gt;Zn-pheophorbide-myoglobin&gt;Zn-bacteriopheophorbide-myoglobin approximately apo-myoglobin.	Zinc	63-65	myoglobin	Homo sapiens	79-88
17490605-2	2007	With guanidinium chloride, the stability order is myoglobin&gt;Zn-pheophorbide-myoglobin&gt;Zn-bacteriopheophorbide-myoglobin approximately apo-myoglobin.	Zinc	63-65	myoglobin	Homo sapiens	79-88
17279683-3	2007	The Cd2+ concentration determined by a Cd2+-specific cellular assay was below the assay detection limit (&lt;5 nM) in cells treated with CdSe/ZnS QDs, while in cells incubated with CdTe QDs, it ranged from approximately 30 to 150 nM, depending on the capping molecule.	Zinc	142-145	CD2 molecule	Homo sapiens	4-7
17279683-3	2007	The Cd2+ concentration determined by a Cd2+-specific cellular assay was below the assay detection limit (&lt;5 nM) in cells treated with CdSe/ZnS QDs, while in cells incubated with CdTe QDs, it ranged from approximately 30 to 150 nM, depending on the capping molecule.	Zinc	142-145	CD2 molecule	Homo sapiens	39-42
16956965-0	2007	Episodic ataxia type 1 mutation F184C alters Zn2+-induced modulation of the human K+ channel Kv1.4-Kv1.1/Kvbeta1.1.	Zinc	45-49	potassium voltage-gated channel subfamily A member 1	Homo sapiens	0-22
16956965-0	2007	Episodic ataxia type 1 mutation F184C alters Zn2+-induced modulation of the human K+ channel Kv1.4-Kv1.1/Kvbeta1.1.	Zinc	45-49	potassium voltage-gated channel subfamily A member 4	Homo sapiens	93-98
16956965-0	2007	Episodic ataxia type 1 mutation F184C alters Zn2+-induced modulation of the human K+ channel Kv1.4-Kv1.1/Kvbeta1.1.	Zinc	45-49	potassium voltage-gated channel subfamily A member 1	Homo sapiens	99-104
16956965-3	2007	It is likely that Kv1.1, Kv1.4, and Kvbeta1.1 subunits form heteromeric channels at hippocampal mossy fiber boutons from which Zn(2+) ions are released into the synaptic cleft in a Ca(2+)-dependent fashion.	Zinc	127-129	potassium voltage-gated channel subfamily A member 1	Homo sapiens	18-23
16956965-3	2007	It is likely that Kv1.1, Kv1.4, and Kvbeta1.1 subunits form heteromeric channels at hippocampal mossy fiber boutons from which Zn(2+) ions are released into the synaptic cleft in a Ca(2+)-dependent fashion.	Zinc	127-129	potassium voltage-gated channel subfamily A member 4	Homo sapiens	25-30
16956965-6	2007	Furthermore, the EA1 mutation F184C, located within the S1 segment of the Kv1.1 subunit, markedly decreased the equilibrium dissociation constants for Zn(2+) binding to the high- and low-affinity sites.	Zinc	151-153	potassium voltage-gated channel subfamily A member 1	Homo sapiens	17-20
16956965-6	2007	Furthermore, the EA1 mutation F184C, located within the S1 segment of the Kv1.1 subunit, markedly decreased the equilibrium dissociation constants for Zn(2+) binding to the high- and low-affinity sites.	Zinc	151-153	potassium voltage-gated channel subfamily A member 1	Homo sapiens	74-79
16956965-8	2007	These results demonstrate that the EA1 mutation F184C will not only sensitize the homomeric Kv1.1 channel to extracellular Zn(2+), but it will also endow heteromeric channels with a higher sensitivity to this metal ion.	Zinc	123-125	potassium voltage-gated channel subfamily A member 1	Homo sapiens	35-38
16956965-8	2007	These results demonstrate that the EA1 mutation F184C will not only sensitize the homomeric Kv1.1 channel to extracellular Zn(2+), but it will also endow heteromeric channels with a higher sensitivity to this metal ion.	Zinc	123-125	potassium voltage-gated channel subfamily A member 1	Homo sapiens	92-97
17085522-13	2007	Zn supplementation normalized ZIP1 and ZIP14, but it did not affect mRNA levels of cytokines or their receptors.	Zinc	0-2	solute carrier family 39 (zinc transporter), member 1	Mus musculus	30-34
17096706-8	2007	The interaction between GPIbalpha and dimeric beta2GPI was of intermediate affinity (Kd = 180 nM) and Zn2+, but not Ca2+-dependent.	Zinc	102-106	apolipoprotein H	Homo sapiens	46-54
17082234-8	2007	In neuroblastoma NG 108-15 cells, the duration of CaV3.3-mediated action potentials is increased upon Zn2+ application, indicating further that Zn2+ behaves as a CaV3.3 channel opener.	Zinc	102-106	caveolin 3	Mus musculus	50-54
17082234-8	2007	In neuroblastoma NG 108-15 cells, the duration of CaV3.3-mediated action potentials is increased upon Zn2+ application, indicating further that Zn2+ behaves as a CaV3.3 channel opener.	Zinc	144-148	caveolin 3	Mus musculus	50-54
17163970-4	2007	The detailed characterization of Crs5 in vivo and in vitro Zn(II)-, Cd(II)- and Cu(I)-binding abilities fully supports its resemblance to mammalian MTs.	Zinc	59-65	ALX homeobox 4	Homo sapiens	33-37
17163970-5	2007	Hence, Crs5 exhibits a good divalent metal-binding ability, yielding homometallic, highly chiral and stable Zn and Cd complexes when expressed in media enriched with these metal ions.	Zinc	108-110	CRS5	Saccharomyces cerevisiae S288C	7-11
17163970-9	2007	Overall, a Crs5 function in global metal cell homeostasis, based on its Zn-binding features, is glimpsed.	Zinc	72-74	CRS5	Saccharomyces cerevisiae S288C	11-15
16723513-0	2006	Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression.	Zinc	46-50	metallothionein 1I, pseudogene	Homo sapiens	121-125
16844841-7	2006	Among further newly implicated proteins are IRT3 and ZIP10, which have been proposed to contribute to cytoplasmic Zn influx, and FRD3 required for iron partitioning in A. thaliana.	Zinc	114-116	zinc transporter 10 precursor	Arabidopsis thaliana	53-58
16533814-8	2006	DOHH activity could be restored only by the addition of Fe2+ to the apoenzyme but not by other metals including Cd2+,Co2+,Cr2+,Cu2+,Mg2+,Mn2+,Ni2+, and Zn2+.	Zinc	152-156	deoxyhypusine hydroxylase	Homo sapiens	0-4
16517595-8	2006	We studied the regulation of hK5 activity by cations (Zn2+, Ca2+, Mg2+, Na2+, and K+) and citrate and showed that Zn can efficiently inhibit hK5 activity at levels well below its normal concentration in the prostate.	Zinc	54-58	keratin 5	Homo sapiens	29-32
16517595-8	2006	We studied the regulation of hK5 activity by cations (Zn2+, Ca2+, Mg2+, Na2+, and K+) and citrate and showed that Zn can efficiently inhibit hK5 activity at levels well below its normal concentration in the prostate.	Zinc	54-56	keratin 5	Homo sapiens	29-32
16517595-10	2006	Semenogelins can reverse the inhibition of hK5 by Zn2+, providing a novel regulatory mechanism of its serine protease activity.	Zinc	50-54	keratin 5	Homo sapiens	43-46
16546209-2	2006	Human placental lactogen (hPL) is highly conserved with human growth hormone (hGH) and both hormones bind to the hPRLR extracellular domain (ECD), the first step in receptor homodimerization, in a Zn2+-dependent manner.	Zinc	197-201	galectin 1	Homo sapiens	26-29
16546209-3	2006	A modified surface plasmon resonance method was developed to measure the kinetics for hPL and hGH binding to the hPRLR ECD, with and without Zn2+ and showed that hPL has about a tenfold higher affinity for the hPRLR ECD1 than hGH.	Zinc	141-145	galectin 1	Homo sapiens	162-165
16443223-4	2006	Here, we show for the first time in dialysates of rat and rabbit brain and human CSF samples from lumbar punctures that: (i) the resting or "tonic" level of free Zn2+ signal in the extracellular fluid of the rat, rabbit and human being is approximately 19 nM (95% range: 5-25 nM).	Zinc	162-166	colony stimulating factor 2	Homo sapiens	81-84
16533897-4	2006	Previously, we demonstrated that thiol-specific reagents inhibit Kv4.1 channels by reacting in a state-dependent manner with native Zn(2+) site thiolate groups in the T1-T1 interface; therefore, we concluded that the T1-T1 interface is functionally active and not protected by Zn(2+) (Wang, G., M. Shahidullah, C.A.	Zinc	132-134	potassium voltage-gated channel subfamily D member 1	Homo sapiens	65-70
16608287-2	2006	Uncoated Qdots made of core/shell CdSe/ZnS are toxic to cells because of the release of Cd2+ ions into the cellular environment.	Zinc	39-42	CD2 molecule	Homo sapiens	88-91
16441845-4	2006	We observed saturable binding of [(125)I]CQ to synthetic Abeta precipitated by Zn(2+) (K(d)=0.45 and 1.40 nm for Abeta(1-42) and Abeta(1-40), respectively), which was fully displaced by free Zn(2+), Cu(2+), the chelator DTPA (diethylene triamine pentaacetic acid) and partially by Congo red.	Zinc	79-81	amyloid beta (A4) precursor protein	Mus musculus	57-62
16441845-4	2006	We observed saturable binding of [(125)I]CQ to synthetic Abeta precipitated by Zn(2+) (K(d)=0.45 and 1.40 nm for Abeta(1-42) and Abeta(1-40), respectively), which was fully displaced by free Zn(2+), Cu(2+), the chelator DTPA (diethylene triamine pentaacetic acid) and partially by Congo red.	Zinc	191-193	amyloid beta (A4) precursor protein	Mus musculus	57-62
16441845-5	2006	Sucrose density gradient of post-mortem AD brain indicated that [(125)I]CQ concentrated in a fraction enriched for both Abeta and Zn, which was modulated by exogenous addition of Zn(2+) or DTPA.	Zinc	179-181	amyloid beta (A4) precursor protein	Mus musculus	120-125
16701860-1	2006	Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as beta(2)-microglobulin (beta(2)-MG) as model proteins.	Zinc	17-19	beta-2-microglobulin	Homo sapiens	224-245
16701860-1	2006	Nano-crystalline Zn-containing hydroxyapatite (ZnHAp) was prepared by the wet-chemical method and the selective adsorption of essential proteins was examined, taking bovine serum albumin (BSA) and pathogenic protein such as beta(2)-microglobulin (beta(2)-MG) as model proteins.	Zinc	17-19	beta-2-microglobulin	Homo sapiens	247-257
17468957-7	2006	Two different types of Cl(-) channels are known to be present in the basolateral membrane of epithelial cells: Zn(2+)-sensitive ClC-2 and DIDS-sensitive bestrophin channels.	Zinc	111-117	galectin 14	Homo sapiens	128-133
16163767-4	2005	Similarly, the reaction of PMAT (15) with Mn(ClO4)2.6H2O or M(BF4)2.6 H2O (M=Fe, Co, Ni, Zn) in a ligand-to-metal molar ratio of 1:1 has afforded a series of complexes with the general formula [M(II) (2)(PMAT)2]X4.	Zinc	89-91	solute carrier family 29 member 4	Homo sapiens	27-31
16163767-4	2005	Similarly, the reaction of PMAT (15) with Mn(ClO4)2.6H2O or M(BF4)2.6 H2O (M=Fe, Co, Ni, Zn) in a ligand-to-metal molar ratio of 1:1 has afforded a series of complexes with the general formula [M(II) (2)(PMAT)2]X4.	Zinc	89-91	solute carrier family 29 member 4	Homo sapiens	204-208
16144831-3	2005	Using structural modeling and functional mutagenesis, we have identified the molecular basis for the elusive Zn(2+) potentiation site on GlyRs and account for the differential sensitivity of GlyR alpha(1) and GlyR alpha(2) to Zn(2+) potentiation.	Zinc	226-228	glycine receptor alpha 1	Homo sapiens	191-219
15946124-0	2005	Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome.	Zinc	0-4	Regulatory particle non-ATPase 10	Drosophila melanogaster	48-53
15946124-0	2005	Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome.	Zinc	0-4	Regulatory particle non-ATPase 10	Drosophila melanogaster	54-57
15946124-1	2005	In the presence of Zn2+, the Drosophila 26 S proteasome disassembles into RP (regulatory particle) and CP (catalytic particle), this process being accompanied by the dissociation of subunit Rpn10/p54, the ubiquitin receptor subunit of the proteasome.	Zinc	19-23	Regulatory particle non-ATPase 10	Drosophila melanogaster	190-195
15946124-1	2005	In the presence of Zn2+, the Drosophila 26 S proteasome disassembles into RP (regulatory particle) and CP (catalytic particle), this process being accompanied by the dissociation of subunit Rpn10/p54, the ubiquitin receptor subunit of the proteasome.	Zinc	19-23	Regulatory particle non-ATPase 10	Drosophila melanogaster	196-199
15946124-4	2005	The Zn2+-induced structural and functional changes are fully reversible; removal of Zn2+ is followed by reassociation of subunit Rpn10/p54 to the RP, reassembly of the 26 S proteasome and resumption of the peptidase activity.	Zinc	4-8	Regulatory particle non-ATPase 10	Drosophila melanogaster	129-134
15946124-4	2005	The Zn2+-induced structural and functional changes are fully reversible; removal of Zn2+ is followed by reassociation of subunit Rpn10/p54 to the RP, reassembly of the 26 S proteasome and resumption of the peptidase activity.	Zinc	4-8	Regulatory particle non-ATPase 10	Drosophila melanogaster	135-138
15946124-5	2005	After the Zn2+-induced dissociation, Rpn10/p54 interacts with a set of non-proteasomal proteins.	Zinc	10-14	Regulatory particle non-ATPase 10	Drosophila melanogaster	37-42
15946124-5	2005	After the Zn2+-induced dissociation, Rpn10/p54 interacts with a set of non-proteasomal proteins.	Zinc	10-14	Regulatory particle non-ATPase 10	Drosophila melanogaster	43-46
15946124-6	2005	Hsp82 (heat-shock protein 82) has been identified by MS as the main Rpn10/p54-interacting protein, suggesting its role in the reassembly of the 26 S proteasome after Zn2+ removal.	Zinc	166-170	Regulatory particle non-ATPase 10	Drosophila melanogaster	68-73
15946124-6	2005	Hsp82 (heat-shock protein 82) has been identified by MS as the main Rpn10/p54-interacting protein, suggesting its role in the reassembly of the 26 S proteasome after Zn2+ removal.	Zinc	166-170	Regulatory particle non-ATPase 10	Drosophila melanogaster	74-77
15946124-10	2005	Rpn10/p54 is permanently RP-bound during the ATP-dependent assembly-disassembly cycle, but during the Zn2+ cycle it reversibly shuttles between the RP-bound and free states.	Zinc	102-106	Regulatory particle non-ATPase 10	Drosophila melanogaster	0-5
15946124-10	2005	Rpn10/p54 is permanently RP-bound during the ATP-dependent assembly-disassembly cycle, but during the Zn2+ cycle it reversibly shuttles between the RP-bound and free states.	Zinc	102-106	Regulatory particle non-ATPase 10	Drosophila melanogaster	6-9
16183033-7	2005	The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect.	Zinc	147-151	solute carrier family 39 member 1	Homo sapiens	115-122
15905212-2	2005	Here, a substantial 30-fold increase in sensitivity to Zn2+-mediated inhibition was apparent for the homomeric glycine receptor (GlyR) alpha1 subunit compared to either GlyR alpha2 or alpha3 subtypes.	Zinc	55-59	adrenoceptor alpha 1D	Homo sapiens	135-141
15905212-3	2005	Swapping the divergent histidine (H107) residue in GlyR alpha1, which together with the conserved H109 forms part of an intersubunit Zn2+-binding site, for the equivalent asparagine residue present in GlyR alpha2 and alpha3, reversed this phenotype.	Zinc	133-137	glycine receptor alpha 1	Homo sapiens	51-62
15905212-4	2005	Co-expression of heteromeric GlyR alpha1 or alpha2 with the ancillary beta subunit yielded receptors that maintained their distinctive sensitivities to Zn2+ inhibition.	Zinc	152-156	glycine receptor alpha 1	Homo sapiens	29-40
15905212-6	2005	Comparative studies to elucidate the specific residue in the beta subunit responsible for this differential sensitivity revealed instead threonine 133 in the alpha1 subunit as a new vital component for Zn2+-mediated inhibition.	Zinc	202-206	adrenoceptor alpha 1D	Homo sapiens	158-164
16099027-6	2005	At the cellular level, Zn inhibits alcohol-induced hepatic apoptosis partially through suppression of the Fas/FasL-mediated pathway.	Zinc	23-25	Fas ligand	Homo sapiens	110-114
15952772-5	2005	Using the microdialysis ATR-FTIR setup, we determined that a histidine and the carboxylate group of a glutamate are involved in Zn(2+) binding.	Zinc	128-130	ATR serine/threonine kinase	Equus caballus	24-27
15952772-7	2005	A two-dimensional NMR analysis of the Zn(2+)-binding site in horse heart cytochrome c confirmed that His 33 and residues close to the C terminus are sensitive to Zn(2+) binding.	Zinc	38-44	cytochrome c, somatic	Equus caballus	73-85
15952772-7	2005	A two-dimensional NMR analysis of the Zn(2+)-binding site in horse heart cytochrome c confirmed that His 33 and residues close to the C terminus are sensitive to Zn(2+) binding.	Zinc	38-40	cytochrome c, somatic	Equus caballus	73-85
15952772-9	2005	From H(2)O/(2)H(2)O exchange experiments, we concluded that the impact of Zn(2+) and Cd(2+) binding on the oxidation kinetics of ferrocytochrome c by H(2)O(2) is associated to the perturbation of a hydrogen-bonding network involving His 33 that is sensitive to the redox state of cytochrome c.	Zinc	74-76	cytochrome c, somatic	Equus caballus	134-146
15952786-6	2005	We present the first experimental evidence that Kti11p can bind a single Zn(2+) ion by its four conserved cysteine residues.	Zinc	73-75	Kti11p	Saccharomyces cerevisiae S288C	48-54
15898798-1	2005	We report on the preparation and structural characterization of CdSe nanocrystals, which are covered by a multishell structure from CdS and ZnS.	Zinc	140-143	CDP-diacylglycerol synthase 1	Homo sapiens	64-67
15839648-1	2005	The physiological electron-transfer (ET) partners, cytochrome c peroxidase (CcP) and cytochrome c (Cc)1, can be modified to exhibit photoinitiated ET through substitution of Zn (or Mg) for Fe in either partner.	Zinc	174-176	C-C motif chemokine ligand 14	Homo sapiens	85-103
15802852-2	2005	The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.	Zinc	4-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
15735762-9	2005	Induction of the hMT1G promoter upon exposure to heavy metals such as Zn and Cd is mediated by the MRE.	Zinc	70-72	metallothionein 1G	Homo sapiens	17-22
15771509-6	2005	These studies reveal that Pb2+ forms tight complexes with cysteine residues in the zinc-binding sites in GATA proteins, beta1Pb = 6.4 (+/- 2.0) x 10(9) M(-1) for CF and beta2 = 6.3 (+/- 6.3) x 10(19) M(-2) for Pb(2+)2-DF, and within an order of magnitude of the affinity of Zn2+ for these proteins.	Zinc	274-278	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	105-109
15708376-3	2005	To contribute towards filling this gap, we have analyzed the influence of chloride anions in the Zn- and Cd-MT complexes of mammalian MT1 and MT4 isoforms.	Zinc	97-99	metallothionein 1I, pseudogene	Homo sapiens	134-137
15781666-5	2005	Paricalcitol induced monocytic differentiation of U937 AML cells, which was partially blocked by inducing expression of APL-related PML-retinoic acid receptor alpha (RARalpha) chimeric protein in the U937 cells containing a Zn2+-inducible expression vector coding for this fusion protein (PR9 cells).	Zinc	224-228	retinoic acid receptor alpha	Homo sapiens	166-174
15721369-7	2005	The Zn(2+) coordination residues of the C-terminal catalytic domain (CD2) were not required for encapsidation but were essential for cytidine deaminase activity and the antiviral effect.	Zinc	4-10	CD2 molecule	Homo sapiens	69-72
15736926-4	2005	By using affinity precipitation and surface plasmon resonance analysis, we show that Zn(7)MT-3 binds reversibly to Rab3A.GDP (K(D) = 2.6 microM), but not to Rab3A.GTP.	Zinc	85-87	RAB3A, member RAS oncogene family	Homo sapiens	115-120
15736926-5	2005	The binding of Zn(7)MT-3 to Rab3A.GDP is specific as no binding was observed with the metal-free form of MT-3.	Zinc	15-17	RAB3A, member RAS oncogene family	Homo sapiens	28-33
15736926-8	2005	The interaction of Zn(7)MT-3 with Rab3A indicates that Zn(7)MT-3 is not merely a cellular Zn(2+) buffer, but actively participates in synaptic vesicle trafficking upstream of vesicle fusion.	Zinc	19-21	RAB3A, member RAS oncogene family	Homo sapiens	34-39
15736926-8	2005	The interaction of Zn(7)MT-3 with Rab3A indicates that Zn(7)MT-3 is not merely a cellular Zn(2+) buffer, but actively participates in synaptic vesicle trafficking upstream of vesicle fusion.	Zinc	55-57	RAB3A, member RAS oncogene family	Homo sapiens	34-39
15736926-8	2005	The interaction of Zn(7)MT-3 with Rab3A indicates that Zn(7)MT-3 is not merely a cellular Zn(2+) buffer, but actively participates in synaptic vesicle trafficking upstream of vesicle fusion.	Zinc	55-57	RAB3A, member RAS oncogene family	Homo sapiens	34-39
16013319-7	2005	Just like Cd-S, the vibration of Zn--S has two peaks as well, which are at about 193 and 155 cm(-1), respectively.	Zinc	33-38	CDP-diacylglycerol synthase 1	Homo sapiens	10-14
15572450-7	2004	We also propose a mechanism for PGN hydrolysis by Zn(2+)-containing PGRPs.	Zinc	50-56	peptidoglycan recognition protein 1	Homo sapiens	68-73
15590814-3	2004	Sequence analysis of this C. albicans UPC2 (CaUPC2) gene identifies two domains, an anchoring transmembrane domain and a transcription factor region containing multiple nuclear localization signals and a fungal Zn(2)-Cys(6) binuclear cluster domain.	Zinc	211-213	Upc2p	Saccharomyces cerevisiae S288C	38-42
15541488-4	2004	Co-incubation of ABri with either Zn(II) or Cu(II) precipitated the peptide but did not result in the formation of amyloid fibrils.	Zinc	34-40	integral membrane protein 2B	Homo sapiens	17-21
15653794-2	2004	We investigated the subcellular localization of Arabidopsis thaliana AtMTP1, a member of the CDF family, and its physiological role in the tolerance to Zn using MTP1-deficient mutant plants.	Zinc	152-154	zinc transporter	Arabidopsis thaliana	69-75
15653794-2	2004	We investigated the subcellular localization of Arabidopsis thaliana AtMTP1, a member of the CDF family, and its physiological role in the tolerance to Zn using MTP1-deficient mutant plants.	Zinc	152-154	zinc transporter	Arabidopsis thaliana	71-75
15653794-6	2004	A T-DNA insertion mutant line for AtMTP1 displays enhanced sensitivity to high Zn concentrations ranging from 200 to 500 microM, but not to Zn-deficient conditions.	Zinc	79-81	zinc transporter	Arabidopsis thaliana	34-40
15653794-7	2004	Mesophyll cells of the mtp1-1 mutant plants grown in the presence of 500 microM Zn were degraded, suggesting that Zn at high concentrations causes serious damage to leaves and that AtMTP1 plays a crucial role in preventing this damage in plants.	Zinc	80-82	zinc transporter	Arabidopsis thaliana	181-187
15653794-8	2004	Thus we propose that AtMTP1 is localized in the vacuolar membrane and is involved in sequestration of excess Zn in the cytoplasm into vacuoles to maintain Zn homeostasis.	Zinc	109-111	zinc transporter	Arabidopsis thaliana	21-27
15653794-8	2004	Thus we propose that AtMTP1 is localized in the vacuolar membrane and is involved in sequestration of excess Zn in the cytoplasm into vacuoles to maintain Zn homeostasis.	Zinc	155-157	zinc transporter	Arabidopsis thaliana	21-27
15535990-8	2004	Interestingly, when Zn was supplemented to nickel treated rats, the activities of catalase, and glutathione-S-transferase and the levels of GSH and lipid peroxidation came back to within normal limits.	Zinc	20-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	96-121
15358788-5	2004	However, in the presence of Mn2+, Zn2+, Co2+, or Cd2+, PARN activity was rescued from the PARN(D28C), PARN(D292C), and PARN(D382C) variants, suggesting that these three amino acids interact with catalytically essential metal ions.	Zinc	34-38	poly(A)-specific ribonuclease	Homo sapiens	55-59
15358788-5	2004	However, in the presence of Mn2+, Zn2+, Co2+, or Cd2+, PARN activity was rescued from the PARN(D28C), PARN(D292C), and PARN(D382C) variants, suggesting that these three amino acids interact with catalytically essential metal ions.	Zinc	34-38	poly(A)-specific ribonuclease	Homo sapiens	90-94
15358788-5	2004	However, in the presence of Mn2+, Zn2+, Co2+, or Cd2+, PARN activity was rescued from the PARN(D28C), PARN(D292C), and PARN(D382C) variants, suggesting that these three amino acids interact with catalytically essential metal ions.	Zinc	34-38	poly(A)-specific ribonuclease	Homo sapiens	90-94
15358788-5	2004	However, in the presence of Mn2+, Zn2+, Co2+, or Cd2+, PARN activity was rescued from the PARN(D28C), PARN(D292C), and PARN(D382C) variants, suggesting that these three amino acids interact with catalytically essential metal ions.	Zinc	34-38	poly(A)-specific ribonuclease	Homo sapiens	90-94
15358788-7	2004	Interestingly, adenosine dinucleotide (A) was efficiently hydrolyzed in the presence of Mn2+, Zn2+, or Co2+, suggesting that the substrate length requirement for PARN can be modulated by the identity of the divalent metal ion.	Zinc	94-98	poly(A)-specific ribonuclease	Homo sapiens	162-166
15672649-6	2004	Zn treatment to protein deficient animals lowered lipid peroxidation and catalase, Gpx and GST activities, and also resulted in a significant elevation in the levels of GSH and SOD activity.	Zinc	0-2	hematopoietic prostaglandin D synthase	Rattus norvegicus	91-94
15475410-0	2004	Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis.	Zinc	100-104	heavy metal atpase 2	Arabidopsis thaliana	12-16
15475410-8	2004	HMA2 interacts with Zn2+ and Cd2+ with high affinity (Zn2+ K(1/2) = 0.11 +/- 0.03 microm and Cd2+ K(1/2) = 0.031 +/- 0.007 microm).	Zinc	20-24	heavy metal atpase 2	Arabidopsis thaliana	0-4
15475410-12	2004	Removal of HMA2 full-length transcript results in Zn2+ accumulation in plant tissues.	Zinc	50-54	heavy metal atpase 2	Arabidopsis thaliana	11-15
15475410-14	2004	These results suggest that HMA2 is responsible for Zn2+ efflux from the cells and therefore is required for maintaining low cytoplasmic Zn2+ levels and normal Zn2+ homeostasis.	Zinc	51-55	heavy metal atpase 2	Arabidopsis thaliana	27-31
15475410-14	2004	These results suggest that HMA2 is responsible for Zn2+ efflux from the cells and therefore is required for maintaining low cytoplasmic Zn2+ levels and normal Zn2+ homeostasis.	Zinc	136-140	heavy metal atpase 2	Arabidopsis thaliana	27-31
15475410-14	2004	These results suggest that HMA2 is responsible for Zn2+ efflux from the cells and therefore is required for maintaining low cytoplasmic Zn2+ levels and normal Zn2+ homeostasis.	Zinc	136-140	heavy metal atpase 2	Arabidopsis thaliana	27-31
15504453-10	2004	Thus, our results indicated that Al3+, Ga3+, and In3+ inhibit PBGS by competing with Zn2+, whereas Tl3+ and In3+ inhibit bovine PBGS by directly oxidizing essential sulfhydryl groups.	Zinc	85-89	aminolevulinate dehydratase	Bos taurus	62-66
15474008-3	2004	The results show that the nature of the inhibition was reversible, slow-binding, non-competitive, and the Ki values of some ions such as Cu2+, Ni2+ and Zn2+ range from 10(-5) to 10(-6) M. Moreover, synergetic inhibitory effect of metal ions and genistein on alpha-glucosidase were studied with kinetics method.	Zinc	152-156	sucrase-isomaltase	Homo sapiens	258-275
15766083-5	2004	After adding Fe(III), Fe(II), Cu(II), Zn(II), Co(II), Ni(II) and Sn(II) to the apo-TOP I, the UV-Vis spectra changed except for Fe(III), which almost did not change at all.	Zinc	38-44	DNA topoisomerase 1-like	Nicotiana tabacum	83-88
15225288-3	2004	Overexpression of the plant CDF family member metal tolerance protein 1 (MTP1) from the Ni/Zn hyperaccumulator Thlaspi goesingense (TgMTP1), in the Saccharomyces cerevisiaeDelta zinc resistance conferring (zrc)1Delta cobalt transporter (cot)1 double mutant, suppressed the Zn sensitivity of this strain.	Zinc	91-93	metal cation transporter COT1	Saccharomyces cerevisiae S288C	162-242
15094391-2	2004	Our previous studies suggested that Zn-induced osteoblast differentiation and Ca2+-, PO4(3-)-stimulated osteopontin (OPN) expression might result from their up-regulation effect on SVCT2 expression and AA uptake.	Zinc	36-38	secreted phosphoprotein 1	Homo sapiens	104-115
15094391-2	2004	Our previous studies suggested that Zn-induced osteoblast differentiation and Ca2+-, PO4(3-)-stimulated osteopontin (OPN) expression might result from their up-regulation effect on SVCT2 expression and AA uptake.	Zinc	36-38	secreted phosphoprotein 1	Homo sapiens	117-120
15081878-7	2004	Micromolar concentrations of Zn2+ inhibited alpha1 GlyR signalling but in contrast to previous reports the metal ion did not appear to potentiate GlyR function at lower concentrations.	Zinc	29-33	glycine receptor alpha 1	Homo sapiens	44-55
15159208-5	2004	Exposure to Zn or V (6.25-50 microM) for 6 hr produced significant increases in IL-6, IL-1 alpha, heat shock protein 70, and connexin 43 (Cx43).	Zinc	12-14	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-119
15159208-6	2004	After 24 hr exposure, Zn induced significant changes in the gene expression of Kv4.2 and KvLQt (potassium channel proteins), the alpha 1 subunit of the L-type calcium channel, and Cx43, as well as IL-6 and IL-1 alpha.	Zinc	22-24	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	79-84
15098203-7	2004	In GD 13 and 20 hearts, two genes critical for heart development, alpha-myosin heavy chain (alpha-MHC) and cardiac troponin I (cTnI), were down-regulated in Zn-deficient fetuses.	Zinc	157-159	troponin I3, cardiac type	Rattus norvegicus	107-125
15098203-7	2004	In GD 13 and 20 hearts, two genes critical for heart development, alpha-myosin heavy chain (alpha-MHC) and cardiac troponin I (cTnI), were down-regulated in Zn-deficient fetuses.	Zinc	157-159	troponin I3, cardiac type	Rattus norvegicus	127-131
15023058-2	2004	In this work, we demonstrate the relationships between ligand binding and conformational stability using a previously designed protein, Ant-F, which undergoes a conformation change upon Zn(II) binding.	Zinc	186-192	solute carrier family 25 member 6	Homo sapiens	136-139
14966866-6	2004	With MT overexpression, we observed an acute buffering effect manifested as a dampening of stimulus-induced increases in [Zn2+]i.	Zinc	122-126	metallothionein 2A	Homo sapiens	5-7
15745020-0	2004	Preparation of nanosized ZnS-passivated CdS particle films via the MOCVD process with co-fed single source precursors.	Zinc	25-28	CDP-diacylglycerol synthase 1	Homo sapiens	40-43
15745020-1	2004	A novel approach was developed to prepare thin films of nanosized ZnS-passivated CdS particles via a metal-organic chemical vapor deposition (MOCVD) process with co-fed single source precursors of CdS and ZnS.	Zinc	66-69	CDP-diacylglycerol synthase 1	Homo sapiens	81-84
15745020-1	2004	A novel approach was developed to prepare thin films of nanosized ZnS-passivated CdS particles via a metal-organic chemical vapor deposition (MOCVD) process with co-fed single source precursors of CdS and ZnS.	Zinc	66-69	CDP-diacylglycerol synthase 1	Homo sapiens	197-200
15745020-1	2004	A novel approach was developed to prepare thin films of nanosized ZnS-passivated CdS particles via a metal-organic chemical vapor deposition (MOCVD) process with co-fed single source precursors of CdS and ZnS.	Zinc	205-208	CDP-diacylglycerol synthase 1	Homo sapiens	81-84
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	36-39	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
15745020-2	2004	Single source precursors of CdS and ZnS with sufficiently different reactivity, as judged from thermogravimetry analysis, were prepared and paired up to form ZnS-passivated CdS, (CdS)ZnS, and CdS-modified ZnS, (ZnS)CdS, particle films in a one-step process.	Zinc	158-161	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
14753790-1	2004	A simple and fast method for simultaneous separation of nine metal cations Ni2+, Cu2+, Co2+, Zn2+ Cd2+, K+, Na+, Mg2+ and Ca2+, and NH4+ in methanol is reported.	Zinc	93-97	CD2 molecule	Homo sapiens	98-101
14564438-3	2004	Ox PUF was found to be very suitable for separation and preconcentration of trace metals, e.g. Zn(II), Cd(II), and Hg(II) ions, from wastewater in the pH ranges 2-12, 9-12, and 3-6, respectively.	Zinc	95-101	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	3-6
15137647-5	2004	Group 2: Pb, Zn, Cd, which are partially volatile.	Zinc	13-15	p38a MAP kinase	Drosophila melanogaster	0-7
15353718-4	2004	In order to improve the gamma-neutron discrimination ability, vacuum evaporation of 6LiF onto the ZnS(Ag) film has been done.	Zinc	98-101	LIF interleukin 6 family cytokine	Homo sapiens	85-88
14581177-17	2003	Extracellular Zn2+ ions (0.1-300 microM) coapplied with ATP inhibited agonist responses at rP2Y4 but not at rP2Y2 receptors.	Zinc	14-18	pyrimidinergic receptor P2Y4	Rattus norvegicus	91-96
14634392-5	2003	RESULTS: A new relationship was found between Zn in prostate tissue and PSA in blood, which allows improved separation between prostate cancer and benign prostate hyperplasia, and might have a significant impact on the reliable diagnosis of prostate cancer.	Zinc	46-48	kallikrein related peptidase 3	Homo sapiens	72-75
14634392-7	2003	The most interesting finding in this study is the relationship between Zn concentration and PSA.	Zinc	71-73	kallikrein related peptidase 3	Homo sapiens	92-95
12944424-1	2003	Carboxypeptidase Z (CPZ) is a secreted Zn-dependent enzyme whose biological function is largely unknown.	Zinc	39-41	carboxypeptidase Z	Gallus gallus	0-18
12944424-1	2003	Carboxypeptidase Z (CPZ) is a secreted Zn-dependent enzyme whose biological function is largely unknown.	Zinc	39-41	carboxypeptidase Z	Gallus gallus	20-23
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	10-12	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14505073-6	2003	Thus, the Zn/Ag replacement in Zn(7)-MT 1 at pH 7.5 has revealed the subsequent formation of Ag(4)Zn(5)-MT, Ag(7)Zn(3)-MT, Ag(8)Zn(3)-MT, Ag(10)Zn(2)-MT, Ag(12)Zn(1)-MT, Ag(x)-MT, x=14-19, whose structure consists of two additive domains only if Zn(II) remains coordinated to the protein.	Zinc	31-33	metallothionein 1I, pseudogene	Homo sapiens	37-41
14608047-2	2003	We demonstrated Zn transporter expression (Zip3, ZnT-1, ZnT-2 and ZnT-4) in rat mammary gland during mid-lactation and we hypothesize that changes in the levels and localization of these transporters play a role in the longitudinal decrease in milk Zn concentration.	Zinc	16-18	solute carrier family 39 member 3	Rattus norvegicus	43-47
14608047-2	2003	We demonstrated Zn transporter expression (Zip3, ZnT-1, ZnT-2 and ZnT-4) in rat mammary gland during mid-lactation and we hypothesize that changes in the levels and localization of these transporters play a role in the longitudinal decrease in milk Zn concentration.	Zinc	16-18	solute carrier family 30 member 1	Rattus norvegicus	49-54
14608047-8	2003	Zn-treated HC11 cells had lower 65Zn uptake and ZIP3 mRNA levels and higher 65Zn export, ZnT-1 and ZnT-2 mRNA levels than untreated cells.	Zinc	0-2	solute carrier family 39 member 3	Rattus norvegicus	48-52
14608047-8	2003	Zn-treated HC11 cells had lower 65Zn uptake and ZIP3 mRNA levels and higher 65Zn export, ZnT-1 and ZnT-2 mRNA levels than untreated cells.	Zinc	0-2	solute carrier family 30 member 1	Rattus norvegicus	89-94
14608047-9	2003	Zn treatment resulted in relocalization from the plasma membrane (Zip3) or Golgi apparatus (ZnT-4) to an intracellular compartment, from an intracellular compartment toward the plasma membrane (ZnT-2) or from a perinuclear to an intracellular compartment (ZnT-1).	Zinc	0-2	solute carrier family 39 member 3	Rattus norvegicus	66-70
14608047-9	2003	Zn treatment resulted in relocalization from the plasma membrane (Zip3) or Golgi apparatus (ZnT-4) to an intracellular compartment, from an intracellular compartment toward the plasma membrane (ZnT-2) or from a perinuclear to an intracellular compartment (ZnT-1).	Zinc	0-2	solute carrier family 30 member 1	Rattus norvegicus	256-261
14596396-2	2003	Because Cd2+ is often found with Zn2+ in the environment and can form fluorescent complexes with chelating fluorophores, a potentially important property of chemosensors for Zn2+ is their selectivity for Zn2+ over Cd2+.	Zinc	33-37	CD2 molecule	Homo sapiens	8-11
14596396-2	2003	Because Cd2+ is often found with Zn2+ in the environment and can form fluorescent complexes with chelating fluorophores, a potentially important property of chemosensors for Zn2+ is their selectivity for Zn2+ over Cd2+.	Zinc	174-178	CD2 molecule	Homo sapiens	8-11
14596396-2	2003	Because Cd2+ is often found with Zn2+ in the environment and can form fluorescent complexes with chelating fluorophores, a potentially important property of chemosensors for Zn2+ is their selectivity for Zn2+ over Cd2+.	Zinc	174-178	CD2 molecule	Homo sapiens	214-217
14596396-2	2003	Because Cd2+ is often found with Zn2+ in the environment and can form fluorescent complexes with chelating fluorophores, a potentially important property of chemosensors for Zn2+ is their selectivity for Zn2+ over Cd2+.	Zinc	174-178	CD2 molecule	Homo sapiens	8-11
14596396-2	2003	Because Cd2+ is often found with Zn2+ in the environment and can form fluorescent complexes with chelating fluorophores, a potentially important property of chemosensors for Zn2+ is their selectivity for Zn2+ over Cd2+.	Zinc	174-178	CD2 molecule	Homo sapiens	214-217
14596396-3	2003	The Zn2+ or Cd2+ complexes of 1 gave an emission band from the 1:1 complex, but the fluorescence intensity for Cd2+ was a half of that for Zn2+.	Zinc	4-8	CD2 molecule	Homo sapiens	111-114
14596396-3	2003	The Zn2+ or Cd2+ complexes of 1 gave an emission band from the 1:1 complex, but the fluorescence intensity for Cd2+ was a half of that for Zn2+.	Zinc	139-143	CD2 molecule	Homo sapiens	12-15
12783875-7	2003	Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+.	Zinc	127-131	alkaline ceramidase 1	Mus musculus	39-45
12898686-0	2003	Stabilization of CoI by ZnII in pure acetonitrile and its reaction with aryl halides.	Zinc	24-28	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	17-20
12743124-9	2003	Further study revealed that Zn2+-induced ubiquitination of PTEN protein may mediate this process.	Zinc	28-32	phosphatase and tensin homolog	Homo sapiens	59-63
12743124-2	2003	Exposure to Zn2+ ions induces Akt activation, suggesting that PTEN may be modulated in this process.	Zinc	12-16	phosphatase and tensin homolog	Homo sapiens	62-66
12743124-4	2003	Treatment with Zn2+ resulted in a significant reduction in levels of PTEN protein in a dose- and time-dependent fashion in a human airway epithelial cell line.	Zinc	15-19	phosphatase and tensin homolog	Homo sapiens	69-73
12743124-6	2003	Concomitantly, levels of PTEN mRNA were also significantly reduced by Zn2+ exposure.	Zinc	70-74	phosphatase and tensin homolog	Homo sapiens	25-29
12743124-7	2003	PTEN phosphatase activity evaluated by measuring Akt phosphorylation decreased after Zn2+ treatment.	Zinc	85-89	phosphatase and tensin homolog	Homo sapiens	0-4
12743124-10	2003	A phosphatidylinositol 3-kinase inhibitor blocked PTEN degradation induced by Zn2+, suggesting that phosphatidylinositol 3-kinase may participate in the regulation of PTEN.	Zinc	78-82	phosphatase and tensin homolog	Homo sapiens	50-54
12743124-10	2003	A phosphatidylinositol 3-kinase inhibitor blocked PTEN degradation induced by Zn2+, suggesting that phosphatidylinositol 3-kinase may participate in the regulation of PTEN.	Zinc	78-82	phosphatase and tensin homolog	Homo sapiens	167-171
12743124-12	2003	In summary, exposure to Zn2+ ions causes PTEN degradation and loss of function, which is mediated by an ubiquitin-associated proteolytic process in the airway epithelium.	Zinc	24-28	phosphatase and tensin homolog	Homo sapiens	41-45
12745081-4	2003	DDP coordinates Zn(2+), and Zn(2+) was found to stimulate the DDP-STAM1 interaction in vitro.	Zinc	16-18	translocase of inner mitochondrial membrane 8A	Homo sapiens	0-3
12745081-4	2003	DDP coordinates Zn(2+), and Zn(2+) was found to stimulate the DDP-STAM1 interaction in vitro.	Zinc	28-30	translocase of inner mitochondrial membrane 8A	Homo sapiens	62-65
12662899-6	2003	Cd(2+) transport via human Nramp2 was inhibited significantly by Cd(2+), Fe(2+), Pb(2+), Mn(2+), Cu(2+), and Ni(2+), while it was not inhibited by Hg(2+) and Zn(2+).	Zinc	158-160	solute carrier family 11 member 2	Homo sapiens	27-33
12209458-3	2002	The structural comparison of porcine brain Cu(4)Zn(3)MT-III with rabbit liver Cd(5)Zn(2)MT-I (II) and Zn(7)MT-I shows that the contents of the random coil structure are obviously increased.	Zinc	48-50	metallothionein-3	Oryctolagus cuniculus	53-59
12209458-5	2002	However, because the bands assigned to the alpha-helix and random coil structures are overlapped in the spectra, the content of random coil structures in Cu(4)Zn(3)MT-III is therefore higher than those in Cd(5)Zn(2)MT-I, Cd(5)Zn(2)MT-II, and Zn(7)MT-I.	Zinc	159-161	metallothionein-3	Oryctolagus cuniculus	164-170
12045193-8	2002	Zn(2+) binding induces a large conformational change in S100A3 perturbing the hydrophobic interface between two S100A3 subunits, as shown by size exclusion chromatography and CD spectroscopy.	Zinc	0-6	S100 calcium binding protein A3	Homo sapiens	56-62
12045193-8	2002	Zn(2+) binding induces a large conformational change in S100A3 perturbing the hydrophobic interface between two S100A3 subunits, as shown by size exclusion chromatography and CD spectroscopy.	Zinc	0-6	S100 calcium binding protein A3	Homo sapiens	112-118
12186550-9	2002	Although denatured beta2m has characteristics of a globally unfolded state, it nevertheless demonstrates the following strong specificity of binding: Cu(2+) &gt; Zn(2+) &gt;&gt; Ni(2+).	Zinc	162-164	beta-2-microglobulin	Homo sapiens	19-25
12167017-2	2002	We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system.	Zinc	108-110	solute carrier family 25 member 6	Homo sapiens	32-35
12167017-2	2002	We engineered a novel protein, "Antennafinger (Ant-F)", whose structure and function can be controlled with Zn(II), by introducing the consensus sequence of a Cys(2)His(2)-type zinc finger protein into a non-metalloprotein scaffold, an Antennapedia homeodomain mutant (Ant-wt), selected using a motif-searching system.	Zinc	108-110	solute carrier family 25 member 6	Homo sapiens	47-50
12167017-3	2002	The circular dichroism studies demonstrate that Ant-F has secondary structures similar to Ant-wt and also changes its conformation due to Zn(II)-binding.	Zinc	138-144	solute carrier family 25 member 6	Homo sapiens	48-51
12167017-5	2002	In addition, the gel mobility shift assay reveals that the DNA binding activity of Ant-F can be regulated through Zn(II)-induced structural alteration.	Zinc	114-120	solute carrier family 25 member 6	Homo sapiens	83-86
12136135-2	2002	Metal-free S100A3, a cysteine-rich Ca(2+)- and Zn(2+)-binding protein, has been crystallized by vapour diffusion under the strict exclusion of oxygen and in the absence of divalent metal ions.	Zinc	47-53	S100 calcium binding protein A3	Homo sapiens	11-17
21180053-5	2002	RESULTS: (1) Zn2+ fluorescence in the hilus of dentate gyrus, CA3 region and the stratum radiatum and stratum oriens of CA1 decreased slightly at forty-eight hours after reperfusion.	Zinc	13-17	carbonic anhydrase 1	Rattus norvegicus	120-123
11983694-1	2002	Previous studies have shown that exposure of cells to Zn2+ ions induces Ras and MAPK activation through the EGF receptor (EGFR).	Zinc	54-58	epidermal growth factor receptor	Mus musculus	108-120
11983694-1	2002	Previous studies have shown that exposure of cells to Zn2+ ions induces Ras and MAPK activation through the EGF receptor (EGFR).	Zinc	54-58	epidermal growth factor receptor	Mus musculus	122-126
11983694-4	2002	Zn2+ induced Src activation in all B82L cell lines, including B82L-par, indicating that Src activation is independent of the presence of the EGFR.	Zinc	0-4	Rous sarcoma oncogene	Mus musculus	13-16
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	31-35	Rous sarcoma oncogene	Mus musculus	2-5
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	31-35	Rous sarcoma oncogene	Mus musculus	142-145
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	31-35	epidermal growth factor receptor	Mus musculus	192-196
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	156-160	Rous sarcoma oncogene	Mus musculus	2-5
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	156-160	Rous sarcoma oncogene	Mus musculus	142-145
11983694-5	2002	A Src kinase inhibitor blocked Zn2+-induced Ras activation in all the B82L cell lines capable of this response, suggesting the involvement of Src kinase in Zn2+-induced Ras activation via the EGFR.	Zinc	156-160	epidermal growth factor receptor	Mus musculus	192-196
11983694-6	2002	Zn2+ induced the association of the EGFR with Src and specifically increased the phosphorylation of EGFR at tyrosine 845 (Tyr-845), a known Src phosphorylation site.	Zinc	0-4	epidermal growth factor receptor	Mus musculus	36-40
11983694-6	2002	Zn2+ induced the association of the EGFR with Src and specifically increased the phosphorylation of EGFR at tyrosine 845 (Tyr-845), a known Src phosphorylation site.	Zinc	0-4	Rous sarcoma oncogene	Mus musculus	46-49
11983694-6	2002	Zn2+ induced the association of the EGFR with Src and specifically increased the phosphorylation of EGFR at tyrosine 845 (Tyr-845), a known Src phosphorylation site.	Zinc	0-4	epidermal growth factor receptor	Mus musculus	100-104
11983694-6	2002	Zn2+ induced the association of the EGFR with Src and specifically increased the phosphorylation of EGFR at tyrosine 845 (Tyr-845), a known Src phosphorylation site.	Zinc	0-4	Rous sarcoma oncogene	Mus musculus	140-143
11983694-7	2002	Stably transfected B82L cells with a point mutation of the EGFR at Tyr-845 (B82L-Y845F) exhibited only basal Ras activity following exposure to Zn2+.	Zinc	144-148	epidermal growth factor receptor	Mus musculus	59-63
11983694-8	2002	These data demonstrate that Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and Zn2+-induced Ras activation.	Zinc	122-126	Rous sarcoma oncogene	Mus musculus	28-31
11983694-8	2002	These data demonstrate that Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and Zn2+-induced Ras activation.	Zinc	122-126	epidermal growth factor receptor	Mus musculus	65-69
12049850-5	2002	Serum, liver, brain and testes glutathione S-transferase (GST) activities were significantly (P&lt;0.05) increased in Zn-deficient rats, the effect was pronounced in rats fed the lowest level of Zn (1/10 of control).	Zinc	118-120	hematopoietic prostaglandin D synthase	Rattus norvegicus	31-56
12049850-5	2002	Serum, liver, brain and testes glutathione S-transferase (GST) activities were significantly (P&lt;0.05) increased in Zn-deficient rats, the effect was pronounced in rats fed the lowest level of Zn (1/10 of control).	Zinc	118-120	hematopoietic prostaglandin D synthase	Rattus norvegicus	58-61
12049850-5	2002	Serum, liver, brain and testes glutathione S-transferase (GST) activities were significantly (P&lt;0.05) increased in Zn-deficient rats, the effect was pronounced in rats fed the lowest level of Zn (1/10 of control).	Zinc	195-197	hematopoietic prostaglandin D synthase	Rattus norvegicus	31-56
12049850-5	2002	Serum, liver, brain and testes glutathione S-transferase (GST) activities were significantly (P&lt;0.05) increased in Zn-deficient rats, the effect was pronounced in rats fed the lowest level of Zn (1/10 of control).	Zinc	195-197	hematopoietic prostaglandin D synthase	Rattus norvegicus	58-61
11976362-10	2002	The results suggest that a Zn(2+)-sensitive acid efflux mechanism, possibly a H(+)-conductive pathway activated by membrane depolarization, contributes to the internal alkalinization observed during anoxia in adult rat CA1 neurons.	Zinc	27-33	carbonic anhydrase 1	Rattus norvegicus	219-222
11756451-6	2002	Similar to other LPPs, SPP1 activity was also independent of any cation requirements, including Mg(2+), and was not inhibited by EDTA but was markedly inhibited by NaF and Zn(2+).	Zinc	172-174	secreted phosphoprotein 1	Homo sapiens	23-27
11863437-3	2002	Here we determine rate and equilibrium constants for the steps involved in PSA*ACT* formation and demonstrate that (a) the effects of added NaCl, polyamines, and Zn(2+) on this process parallel their effects on PSA catalytic activity [Hsieh, M.-C., and Cooperman, B. S. (2000) Biochim.	Zinc	162-164	kallikrein related peptidase 3	Homo sapiens	75-78
11863437-3	2002	Here we determine rate and equilibrium constants for the steps involved in PSA*ACT* formation and demonstrate that (a) the effects of added NaCl, polyamines, and Zn(2+) on this process parallel their effects on PSA catalytic activity [Hsieh, M.-C., and Cooperman, B. S. (2000) Biochim.	Zinc	162-164	kallikrein related peptidase 3	Homo sapiens	211-214
11833084-9	2002	CONCLUSION: While mother-rats were exposed to manganese, the metabolisms of Mn Zn and Fe of new-born rats in the livers were influenced and were situated in a stress status, thus HSP70 syntheses is induced in the brains and livers of new-born rats, but the mechanism of this effect in the developmental toxicity of Mn remains to be further studied.	Zinc	79-81	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	179-184
11714284-0	2001	IIA(Glc) allosteric control of Escherichia coli glycerol kinase: binding site cooperative transitions and cation-promoted association by Zinc(II).	Zinc	137-145	colicin Ia immunity protein	Escherichia coli	0-3
11763448-6	2001	It was found that hard Lewis acid type metal cations such as K+ and Mg2+, and borderline or soft metal cations such as Zn2+, Cu2+, and Cd2+ exhibit clearly different binding activity toward peptide-lipid monolayers.	Zinc	119-123	CD2 molecule	Homo sapiens	135-138
11533229-6	2001	Ecm22p and Upc2p are members of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors and share no homology to the analogous proteins, SREBPs, that are responsible for transcriptional regulation by sterols in humans.	Zinc	52-57	Upc2p	Saccharomyces cerevisiae S288C	11-16
11531997-2	2001	We investigated Mn2+- and Zn2+-induced site-specific RNA cleavage to identify metal ions that fit into binding pockets within the structurally conserved bI1 group II intron domains (DI-DVI), which might fulfill essential roles in intron function.	Zinc	26-30	transmembrane BAX inhibitor motif containing 6	Homo sapiens	153-156
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	Zinc	0-2	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	182-191
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	Zinc	0-6	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	182-191
11278651-4	2001	We clarified that LUN is localized to the nucleus and reveals Zn(2+)-dependent DNA binding activity.	Zinc	62-68	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	18-21
11058603-5	2001	Regardless of the concentration of Zn2+ in the media, the msc2 strain had a higher Zn2+ content than wild type cells.	Zinc	83-87	metal cation transporter MSC2	Saccharomyces cerevisiae S288C	58-62
11058603-6	2001	Zinquin staining also revealed that msc2 had a marked increase in fluorescence compared with the wild type, again reflecting an increase in intracellular Zn2+.	Zinc	154-158	metal cation transporter MSC2	Saccharomyces cerevisiae S288C	36-40
11160420-5	2001	Mutation of these redox-sensitive cysteine residues also affects high-affinity, voltage-independent Zn(2+) inhibition that is specific to NR1/NR2A receptors.	Zinc	100-102	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	138-141
11208937-5	2001	When zinc intake was low (&lt;1 mg Zn/kg), ZnT-2 mRNA was extremely low in small intestine and kidney compared with an adequate intake (30 mg Zn/kg).	Zinc	35-37	solute carrier family 30 member 2	Rattus norvegicus	43-48
11123375-3	2001	Allosteric interactions with polyamines, Mg(2+), Zn(2+), glutamate, glycine, and their antagonists were consistent with NMDA receptors with NR2B subtype pharmacology.	Zinc	49-55	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	140-144
11400211-7	2001	With increasing amounts of Zn(2+), additional Zn(2+) ions were detected bound to VDR and RXR alpha.	Zinc	27-29	vitamin D receptor	Homo sapiens	81-84
11400211-7	2001	With increasing amounts of Zn(2+), additional Zn(2+) ions were detected bound to VDR and RXR alpha.	Zinc	27-29	retinoid X receptor alpha	Homo sapiens	89-98
11400211-7	2001	With increasing amounts of Zn(2+), additional Zn(2+) ions were detected bound to VDR and RXR alpha.	Zinc	46-48	vitamin D receptor	Homo sapiens	81-84
11400211-7	2001	With increasing amounts of Zn(2+), additional Zn(2+) ions were detected bound to VDR and RXR alpha.	Zinc	46-48	retinoid X receptor alpha	Homo sapiens	89-98
11400211-9	2001	DNA-protein complex formation increased on addition of Zn(2+) up to 200 microM; at 300 microM, Zn(2+) dissociation of the RXR alpha homodimer/OP-VDRE complexes occurred, coincident with the appearance of RXR alpha monomeric protein.	Zinc	55-57	retinoid X receptor alpha	Homo sapiens	122-131
11400211-9	2001	DNA-protein complex formation increased on addition of Zn(2+) up to 200 microM; at 300 microM, Zn(2+) dissociation of the RXR alpha homodimer/OP-VDRE complexes occurred, coincident with the appearance of RXR alpha monomeric protein.	Zinc	95-97	retinoid X receptor alpha	Homo sapiens	122-131
11400211-13	2001	Addition of 300 microM Zn(2+) resulted in dissociation of the heterodimeric VDR/RXR alpha/OP-VDRE complex.	Zinc	23-25	vitamin D receptor	Homo sapiens	76-79
11400211-13	2001	Addition of 300 microM Zn(2+) resulted in dissociation of the heterodimeric VDR/RXR alpha/OP-VDRE complex.	Zinc	23-25	retinoid X receptor alpha	Homo sapiens	80-89
11123909-0	2000	Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites.	Zinc	93-97	solute carrier family 6 member 3	Homo sapiens	43-63
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Zinc	37-43	solute carrier family 6 member 3	Homo sapiens	111-131
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Zinc	37-43	tetraspanin 16	Homo sapiens	280-284
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Zinc	78-84	solute carrier family 6 member 3	Homo sapiens	111-131
11123909-1	2000	Previously, we have identified three Zn(2+) binding residues in an endogenous Zn(2+) binding site in the human dopamine transporter (hDAT): (193)His in extracellular loop 2 (ECL 2), (375)His at the external end of transmembrane segment (TM) 7, and (396)Glu at the external end of TM 8.	Zinc	78-84	tetraspanin 16	Homo sapiens	280-284
11209758-8	2000	Zn2+ ions, sulfhydryl reagents, and aminopeptidase inhibitors, especially probestin, inhibited the rat DPP III more potently.	Zinc	0-4	dipeptidylpeptidase 3	Rattus norvegicus	103-110
11069774-1	2000	CCZ1 was previously identified by the sensitivity of ccz1(delta) mutants to high concentrations of Caffeine and the divalent ions Ca(2+ )and Zn(2+).	Zinc	141-143	Ccz1p	Saccharomyces cerevisiae S288C	0-4
11069774-1	2000	CCZ1 was previously identified by the sensitivity of ccz1(delta) mutants to high concentrations of Caffeine and the divalent ions Ca(2+ )and Zn(2+).	Zinc	141-143	Ccz1p	Saccharomyces cerevisiae S288C	53-57
11087412-10	2000	In addition, closely similar apparent stability constants of human MT-3, mutMT-3, and rabbit MT-2a with Cd(II) and Zn(II) ions were found.	Zinc	115-121	metallothionein 3	Homo sapiens	67-80
11087412-10	2000	In addition, closely similar apparent stability constants of human MT-3, mutMT-3, and rabbit MT-2a with Cd(II) and Zn(II) ions were found.	Zinc	115-121	metallothionein-2A	Oryctolagus cuniculus	93-98
11018793-0	2000	Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses.	Zinc	11-17	carbonic anhydrase 3	Rattus norvegicus	105-108
11018793-11	2000	Our results indicate that the endogenous Zn(2+) is specifically required for LTP induction at the mossy fiber input into CA3 neurons.	Zinc	41-43	carbonic anhydrase 3	Rattus norvegicus	121-124
10807919-4	2000	As exemplified by Cd(2+)- and Zn(2+)-dependent AtPCS1-mediated catalysis, the kinetics of PC synthesis approximate a substituted enzyme mechanism in which micromolar heavy metal glutathione thiolate (e.g. Cd.GS(2) or Zn.GS(2)) and free glutathione act as gamma-Glu-Cys acceptor and donor.	Zinc	30-36	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	47-53
10807919-4	2000	As exemplified by Cd(2+)- and Zn(2+)-dependent AtPCS1-mediated catalysis, the kinetics of PC synthesis approximate a substituted enzyme mechanism in which micromolar heavy metal glutathione thiolate (e.g. Cd.GS(2) or Zn.GS(2)) and free glutathione act as gamma-Glu-Cys acceptor and donor.	Zinc	30-32	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	47-53
11029652-1	2000	Rapid Zn2+ influx through Ca2+-permeable AMPA/kainate (Ca-A/K) channels triggers reactive oxygen species (ROS) generation and is potently neurotoxic.	Zinc	6-10	teashirt zinc finger homeobox 1	Homo sapiens	55-61
11029652-5	2000	Consistent with inhibition of mitochondrial Zn2+ uptake, FCCP also slowed the recovery of cytosolic Zn2+ elevations in Ca-A/K(+) neurons.	Zinc	100-104	teashirt zinc finger homeobox 1	Homo sapiens	119-125
10964414-10	2000	These data indicate that CA II binds transition metals with high affinity and is much more selective for Zn(2+) over Ni(2+) or Cd(2+) than most small-molecule chelators or other metalloenzymes.	Zinc	105-107	carbonic anhydrase 2	Homo sapiens	25-30
10974115-5	2000	Subsequent expression of insA-7 from a heterologous promoter in E. coli conferred tolerance to Zn(II).	Zinc	95-97	hypothetical protein	Escherichia coli	25-29
10908293-6	2000	The metal-ion chelator, phenantroline, which in the beta(2)-adrenergic receptor increased both the potency and the agonistic efficacy of Zn(2+) or Cu(2+) in complex with the chelator, also bound to the metal-ion site-engineered NK(1) receptor, but here the metal-ion chelator complex instead acted as a pure antagonist.	Zinc	137-139	adrenoceptor beta 2	Homo sapiens	52-79
11196876-8	2000	The dinuclear model complex is only 1.8 times more reactive in hydrolyzing phosphodiesters than a mononuclear analogue, Zn(bpta)(OTf)2, where bpta = N,N-bis(2-pyridylmethyl)-tert-butylamine.	Zinc	120-122	POU class 2 homeobox 2	Homo sapiens	129-134
10787404-4	2000	PDE with only tightly bound Zn(2+) and no free metal ions was inactive, but activity was fully restored by Mg(2+), Mn(2+), Co(2+), or Zn(2+).	Zinc	28-30	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-3
10787404-4	2000	PDE with only tightly bound Zn(2+) and no free metal ions was inactive, but activity was fully restored by Mg(2+), Mn(2+), Co(2+), or Zn(2+).	Zinc	134-136	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-3
10952009-6	2000	The dimeric and tetrameric hMT proteins exhibited both Cd and Zn binding activities that were respectively two and four times higher than those of the hMT-II monomer protein.	Zinc	62-64	histamine N-methyltransferase	Homo sapiens	27-30
10777777-2	2000	In light of evidence that levels of intracellular free Zn(2+) associated with neurotoxicity may be sufficient to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), experiments were performed looking for reduced glycolysis and energy failure in cultured mouse cortical neurons subjected to lethal Zn(2+) exposure.	Zinc	55-57	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	121-161
10777777-2	2000	In light of evidence that levels of intracellular free Zn(2+) associated with neurotoxicity may be sufficient to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), experiments were performed looking for reduced glycolysis and energy failure in cultured mouse cortical neurons subjected to lethal Zn(2+) exposure.	Zinc	55-57	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	163-168
10777777-4	2000	However, an alternative to direct Zn(2+) inhibition of GAPDH was raised by the observation that Zn(2+) exposure also induced an early decrease in nicotinamide-adenine dinucleotide (NAD(+)) levels, an event itself capable of inhibiting GAPDH.	Zinc	34-40	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	55-60
10777777-4	2000	However, an alternative to direct Zn(2+) inhibition of GAPDH was raised by the observation that Zn(2+) exposure also induced an early decrease in nicotinamide-adenine dinucleotide (NAD(+)) levels, an event itself capable of inhibiting GAPDH.	Zinc	96-102	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	55-60
10777777-4	2000	However, an alternative to direct Zn(2+) inhibition of GAPDH was raised by the observation that Zn(2+) exposure also induced an early decrease in nicotinamide-adenine dinucleotide (NAD(+)) levels, an event itself capable of inhibiting GAPDH.	Zinc	96-102	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	235-240
10819460-10	2000	These Zn2+ complexes showed some relevant biochemical and biological properties such as inhibition of transcriptional factor, TATA binding protein, or strong antimicrobial activities to gram-positive bacterial strains.	Zinc	6-10	TATA-box binding protein	Homo sapiens	126-146
10644722-3	2000	However, a model for human PBGS based on homologous crystal structures shows the location of the allelic variation to be distant from the active site with its two Zn(II).	Zinc	163-165	aminolevulinate dehydratase	Homo sapiens	27-31
10682938-4	1999	CAIII is expressed as one of the major Zn-binding proteins in the livers of male rats in an age-dependent manner, a comparable amount of Zn to that of copper, Zn-superoxide dismutase (Cu,Zn-SOD) being bound to CAIII at 8 weeks of age.	Zinc	39-41	carbonic anhydrase 3	Rattus norvegicus	0-5
10682938-4	1999	CAIII is expressed as one of the major Zn-binding proteins in the livers of male rats in an age-dependent manner, a comparable amount of Zn to that of copper, Zn-superoxide dismutase (Cu,Zn-SOD) being bound to CAIII at 8 weeks of age.	Zinc	137-139	carbonic anhydrase 3	Rattus norvegicus	0-5
10682938-5	1999	Castration at 4 or 8 weeks of age was shown to reduce Zn bound to CAIII to 47.5% of the sham-operated control level, suggesting that the sex-dependent expression of CAIII is partly regulated by a sex hormone, androgen.	Zinc	54-56	carbonic anhydrase 3	Rattus norvegicus	66-71
10682938-5	1999	Castration at 4 or 8 weeks of age was shown to reduce Zn bound to CAIII to 47.5% of the sham-operated control level, suggesting that the sex-dependent expression of CAIII is partly regulated by a sex hormone, androgen.	Zinc	54-56	carbonic anhydrase 3	Rattus norvegicus	165-170
10682938-6	1999	The concentration of CAIII in the livers of Long-Evans rats with a cinnamon-like coat color (LEC rats), an animal model of Wilson disease, was also estimated as Zn bound to CAIII and shown to be lower than that in Wistar rats before the onset of hepatitis.	Zinc	161-163	carbonic anhydrase 3	Rattus norvegicus	21-26
10493186-15	1999	Protein oxidative damage assessed by glutamine synthetase activity was increased by both Zn deficiency and fructose feeding.	Zinc	89-91	glutamate-ammonia ligase	Rattus norvegicus	37-57
10460753-8	1999	The protein tyrosine phosphatase PTP1B, immunoprecipitated from HAEC, was similarly inhibited by V and Zn but not by As ions.	Zinc	103-105	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	33-38
10561075-7	1999	Analysis of the interaction of ATFP3 with metal-chelating columns (IMAC) suggested that it binds to Cu2+, Ni2+, or Zn2+.	Zinc	115-119	farnesylated protein 3	Arabidopsis thaliana	31-36
10406802-7	1999	Ectopic overexpression of AtMHX in transgenic tobacco plants render them sensitive to growth on media containing elevated levels of Mg(2+) or Zn(2+), but does not affect the total amounts of these minerals in shoots of the transgenic plants.	Zinc	142-144	magnesium/proton exchanger	Arabidopsis thaliana	26-31
10406802-9	1999	This localization suggests that AtMHX may control the partitioning of Mg(2+) and Zn(2+) between the various plant organs.	Zinc	81-83	magnesium/proton exchanger	Arabidopsis thaliana	32-37
10499288-5	1999	Moreover, it is interesting to note that the Zn/HL2 complex exhibits specific cytotoxic activity against Pam-ras cells (cis-DDP resistant cells which over-express the H-ras oncogene) with an in vitro therapeutic index of 3.26 versus 0.78 for cis-DDP.	Zinc	45-47	asialoglycoprotein receptor 2	Mus musculus	48-51
10499288-5	1999	Moreover, it is interesting to note that the Zn/HL2 complex exhibits specific cytotoxic activity against Pam-ras cells (cis-DDP resistant cells which over-express the H-ras oncogene) with an in vitro therapeutic index of 3.26 versus 0.78 for cis-DDP.	Zinc	45-47	Harvey rat sarcoma virus oncogene	Mus musculus	167-172
10080937-3	1999	CPZ has a neutral pH optimum, and is inhibited by chelating agents and several divalent cations (Zn2+, Mn2+, Cd2+, Cu2+, Hg2+).	Zinc	97-101	carboxypeptidase Z	Homo sapiens	0-3
10095015-2	1999	Recent studies show that Zn at high concentrations accelerates aggregation of amyloid beta peptide (Abeta), the major component of senile plaques in Alzheimer"s disease (AD).	Zinc	25-27	amyloid beta precursor protein	Rattus norvegicus	100-105
10095015-8	1999	However, in cortical cultures exposed to a toxic dose of Abeta (50 microM), Zn at concentrations of 5 and 0.5 microM led to significant increases in Na+/K+ ATPase activity compared with levels in cells treated with Abeta alone.	Zinc	76-78	amyloid beta precursor protein	Rattus norvegicus	57-62
10095015-8	1999	However, in cortical cultures exposed to a toxic dose of Abeta (50 microM), Zn at concentrations of 5 and 0.5 microM led to significant increases in Na+/K+ ATPase activity compared with levels in cells treated with Abeta alone.	Zinc	76-78	amyloid beta precursor protein	Rattus norvegicus	215-220
10095015-10	1999	Together, these data suggest that Zn functions as a double-edged sword, affording protection against Abeta at low concentrations and enhancing toxicity at high concentrations.	Zinc	34-36	amyloid beta precursor protein	Rattus norvegicus	101-106
10201329-5	1999	Results also indicate that plasma ANP and zinc levels are proportionally related, whereas there is an inverse relationship between plasma ANP levels and heart Zn2+ concentrations, in both cold and hot exposed rats.	Zinc	159-163	natriuretic peptide A	Rattus norvegicus	138-141
9758163-7	1998	The neuropeptide release elicited by D-serine was strongly inhibited by ifenprodil (0.3 microM) and by Zn2+ ions (50 nM), selective ligands at the NR2B and NR2A subunits of NMDA receptors, respectively.	Zinc	103-107	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	147-151
9685393-3	1998	We found that native COMP binds to collagen I/II and procollagen I/II and that the interaction is dependent on the divalent cations Zn2+ or Ni2+, whereas Ca2+, Mg2+, and Mn2+ did not promote binding.	Zinc	132-136	cartilage oligomeric matrix protein	Homo sapiens	21-25
9685393-6	1998	Furthermore, metal chelate chromatography demonstrated that COMP bound Zn2+ and Ni2+.	Zinc	71-75	cartilage oligomeric matrix protein	Homo sapiens	60-64
9685393-9	1998	COMP interacted via its C-terminal globular domain and significantly only in the presence of Zn2+.	Zinc	93-97	cartilage oligomeric matrix protein	Homo sapiens	0-4
9687495-2	1998	Here we report novel insight into the translocation mechanism by delineation of an endogenous Zn2+-binding site in the human dopamine transporter (hDAT).	Zinc	94-98	solute carrier family 6 member 3	Homo sapiens	125-145
9687495-2	1998	Here we report novel insight into the translocation mechanism by delineation of an endogenous Zn2+-binding site in the human dopamine transporter (hDAT).	Zinc	94-98	solute carrier family 6 member 3	Homo sapiens	147-151
9687495-3	1998	In micromolar concentrations, Zn2+ was found to act as a potent, non-competitive blocker of dopamine uptake in COS cells expressing hDAT.	Zinc	30-34	solute carrier family 6 member 3	Homo sapiens	132-136
9687495-8	1998	His375 conserved between hDAT and hNET, present in the fourth extracellular loop (ECL4) at the top of transmembrane segment VII, was identified as a second major coordinate for Zn2+ binding.	Zinc	177-181	solute carrier family 6 member 3	Homo sapiens	25-29
9820663-4	1998	Zn2+ and Mn2+ were able to diminish Cd2+ induced hsp70 mRNA levels by 65%.	Zinc	0-4	heat shock protein family A (Hsp70) member 4	Homo sapiens	49-54
10923465-4	1998	Northern blot showed that human apo AI mRNA was expressed mainly in the liver and kidneys, and the high level of h-apo AI mRNA was obtained in liver, kidneys and small intestine after Zinc(Zn) induction.	Zinc	189-191	apolipoprotein A-I	Mus musculus	115-121
9528006-3	1998	The VDR DBD was shown to bind to the appropriate DNA sequence only when bound to 2 moles of zinc (Zn2+) or cadmium (Cd2+) per mole of protein.	Zinc	98-102	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	4-7
9528006-5	1998	These results show that the VDR DBD/DNA metal-dependent association occurs when the receptor is occupied by 2 moles of Zn2+ per mole of protein and that further binding of Zn2+ to the protein causes dissociation of the complex.	Zinc	119-123	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	28-31
9528006-5	1998	These results show that the VDR DBD/DNA metal-dependent association occurs when the receptor is occupied by 2 moles of Zn2+ per mole of protein and that further binding of Zn2+ to the protein causes dissociation of the complex.	Zinc	172-176	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	28-31
9452440-1	1998	Novel effects of Zn2+ GroEL interactions.	Zinc	17-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	22-27
9437008-10	1998	rTASK currents also were inhibited by Zn2+ (IC50 = 175 microM), the local anesthetic bupivacaine (IC50 = 68 microM), and the anti-convulsant phenytoin ( approximately 50% inhibition at 200 microM).	Zinc	38-42	potassium two pore domain channel subfamily K member 3	Rattus norvegicus	0-5
9463470-0	1998	Zn2+ blocks the NMDA- and Ca2+ -triggered postexposure current ipe in hippocampal pyramidal cells.	Zinc	0-4	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	26-29
9679591-1	1998	Electrospray ionization mass spectrometry (ESI-MS) was used to measure conformational changes within the DNA-binding domain of the vitamin D receptor (VDR DBD) upon binding zinc (Zn2+).	Zinc	179-183	vitamin D receptor	Homo sapiens	131-149
9679591-1	1998	Electrospray ionization mass spectrometry (ESI-MS) was used to measure conformational changes within the DNA-binding domain of the vitamin D receptor (VDR DBD) upon binding zinc (Zn2+).	Zinc	179-183	vitamin D receptor	Homo sapiens	151-154
9679591-2	1998	As increasing concentrations of Zn2+ were added to the VDR DBD, a gradual shift in the mass envelope to lower charge states was observed in the multiply charged spectrum.	Zinc	32-36	vitamin D receptor	Homo sapiens	55-58
9231716-4	1997	The low [Ca2+]e-induced response is also blocked by replacement of extracellular Ca2+ with Ba2+, Zn2+, or Ni2+, and by 100 microM La3+.	Zinc	97-101	carbonic anhydrase 2	Homo sapiens	9-12
9184145-7	1997	Interestingly, the binding between HRG and IgG was significantly potentiated (Kd reduced from 85.0 to 18.9 nM) by the presence of physiological concentrations of Zn2+ (20 microM).	Zinc	162-166	histidine rich glycoprotein	Homo sapiens	35-38
9184145-8	1997	Conversely, the presence of Zn2+ weakened the binding of HRG to C1q (Kd increased from 7.80 to 29.3 nM).	Zinc	28-32	histidine rich glycoprotein	Homo sapiens	57-60
9184145-11	1997	The results show that human HRG binds to C1q and to IgG in a Zn2+-modulated fashion, and that HRG can regulate the formation of IIC in vitro, thus indicating a new functional role for HRG in vivo.	Zinc	61-65	histidine rich glycoprotein	Homo sapiens	28-31
9153200-8	1997	The HRG.Zn complex effectively competes with antithrombin for heparin, which restricts the availability of heparin to bind antithrombin and allows thrombin-mediated fibrinogenesis to proceed unimpeded.	Zinc	8-10	histidine rich glycoprotein	Homo sapiens	4-7
9210485-0	1997	Influence of Zn2+ on the kinetic events that contribute to the 500-kDa dextran-sulfate-dependent activation of factor XII (Hageman factor).	Zinc	13-17	coagulation factor XII	Homo sapiens	123-137
9084432-4	1997	These enzymes have the characteristics of MMPs because they were inhibited by EDTA and 1, 10-phenanthroline, and their activities were restored by addition of both Ca2+ and Zn2+.	Zinc	173-177	matrix metallopeptidase 9	Homo sapiens	42-46
9078480-7	1997	Somatotropin treatment led to decreased hepatic Cr, Cu, Fe, and Zn concentrations and increased total renal Cu, Fe, and Zn.	Zinc	64-66	somatotropin	Sus scrofa	0-12
9078480-7	1997	Somatotropin treatment led to decreased hepatic Cr, Cu, Fe, and Zn concentrations and increased total renal Cu, Fe, and Zn.	Zinc	120-122	somatotropin	Sus scrofa	0-12
9078480-10	1997	Somatotropin effects on tissue Cr, Cu, Zn, and Fe were variable and difficult to evaluate due in part to growth hormone-induced changes in organ weights.	Zinc	39-41	somatotropin	Sus scrofa	0-12
9983291-0	1996	Spin-Peierls lattice fluctuations of pure and Si- and Zn-substituted CuGeO3.	Zinc	54-56	spindlin 1	Homo sapiens	0-4
8928918-2	1996	Involvement of the apical Ca2+ uptake sites in Zn2+ uptake was examined in vivo by pharmacological manipulation of the apical Ca2+ permeability.	Zinc	47-51	carbonic anhydrase II	Oncorhynchus mykiss	26-29
8928918-2	1996	Involvement of the apical Ca2+ uptake sites in Zn2+ uptake was examined in vivo by pharmacological manipulation of the apical Ca2+ permeability.	Zinc	47-51	carbonic anhydrase II	Oncorhynchus mykiss	126-129
8928918-10	1996	The same system was used to study potential effects of Zn2+ on the basolateral Ca2+(-)adenosinetri-phosphatase.	Zinc	55-59	carbonic anhydrase II	Oncorhynchus mykiss	79-82
8928918-11	1996	Zn2+ was found to be a potent blocker of this transporter, causing a mixed inhibitory effect on the ATP driven Ca2+ transport at a free Zn2+ activity of 100 pM.	Zinc	0-4	carbonic anhydrase II	Oncorhynchus mykiss	111-114
8928918-11	1996	Zn2+ was found to be a potent blocker of this transporter, causing a mixed inhibitory effect on the ATP driven Ca2+ transport at a free Zn2+ activity of 100 pM.	Zinc	136-140	carbonic anhydrase II	Oncorhynchus mykiss	111-114
9052935-0	1996	Zn(2+)-induction of metallothionein in myotomal cell nuclei during somitogenesis of Xenopus laevis.	Zinc	0-2	metallothionein 4 L homeolog	Xenopus laevis	20-35
9052935-1	1996	The localization of metallothionein in control and Zn-exposed embryos of Xenopus laevis was studied by whole-mount immunohistochemical staining.	Zinc	51-53	metallothionein 4 L homeolog	Xenopus laevis	20-35
9052935-5	1996	The staining of metallothionein at these sites was more intense in Zn-exposed embryos than controls.	Zinc	67-69	metallothionein 4 L homeolog	Xenopus laevis	16-31
9052935-6	1996	The central nervous system (especially the spinal cord) and the yolk mass were faintly stained for metallothionein in controls and Zn-exposed embryos.	Zinc	131-133	metallothionein 4 L homeolog	Xenopus laevis	99-114
9052935-8	1996	This is the first report that metallothionein is expressed in myotomal cell nuclei of Xenopus embryos during normal somitogenesis and becomes increased when the embryos are exposed to teratogenic levels of Zn2+.	Zinc	206-210	metallothionein 4 L homeolog	Xenopus laevis	30-45
8573077-6	1996	Direct estimations of the metal content in purified DCT preparations show the presence of around 1.5 Zn atoms/molecule and the absence of copper.	Zinc	101-103	dopachrome tautomerase	Homo sapiens	52-55
8573077-8	1996	Our results are consistent with Zn2+ chelation by the highly conserved histidine residues homologous to the histidines at the classical copper-binding sites in tyrosinase.	Zinc	32-36	tyrosinase	Homo sapiens	160-170
8821523-6	1996	HPLC analysis demonstrated these metabolites were the Zn and Cu forms of the drug, resulting from displacement of the Ca ion in the NaCa DTPA-BMA molecule by endogeneous Zn or Cu.	Zinc	54-56	nascent polypeptide associated complex subunit alpha	Rattus norvegicus	132-136
8821523-6	1996	HPLC analysis demonstrated these metabolites were the Zn and Cu forms of the drug, resulting from displacement of the Ca ion in the NaCa DTPA-BMA molecule by endogeneous Zn or Cu.	Zinc	170-172	nascent polypeptide associated complex subunit alpha	Rattus norvegicus	132-136
9131802-1	1996	Azidometalkojates of the general formula MX2 (M = Cu, Mn, Mg, Zn or Ni and X = 5-hydroxy-2-azidomethyl-4H-pyran-4-one) were prepared and tested for antibacterial, antifungal and cytotoxic effects.	Zinc	62-64	MX dynamin like GTPase 2	Homo sapiens	41-44
8720110-8	1996	Bacterial endotoxin-lipopolysaccharide (LPS) and Zn are powerful inducers of MT-I and MT-II gene expression in many adult organs, whereas these agents apparently have little effect on MT-III and MT-IV gene expression.	Zinc	49-51	metallothionein 4	Mus musculus	195-200
7664666-15	1995	The cleavage of pro-TRH was enhanced by Ca2+ and partially inhibited by Zn2+.	Zinc	72-76	thyrotropin releasing hormone	Mus musculus	16-23
9981559-0	1995	Spin dynamics in pure and Zn-doped CuGeO3 by muon spin relaxation: Spin-Peierls and spin-glass transitions.	Zinc	26-28	spindlin 1	Homo sapiens	0-4
9981559-0	1995	Spin dynamics in pure and Zn-doped CuGeO3 by muon spin relaxation: Spin-Peierls and spin-glass transitions.	Zinc	26-28	spindlin 1	Homo sapiens	50-54
9981559-0	1995	Spin dynamics in pure and Zn-doped CuGeO3 by muon spin relaxation: Spin-Peierls and spin-glass transitions.	Zinc	26-28	spindlin 1	Homo sapiens	67-71
9981559-0	1995	Spin dynamics in pure and Zn-doped CuGeO3 by muon spin relaxation: Spin-Peierls and spin-glass transitions.	Zinc	26-28	spindlin 1	Homo sapiens	84-88
7645027-3	1995	The MT-TG mice had 50% more Zn in liver and 300% more Zn in pancreas than control mice.	Zinc	28-30	tRNA glycine, mitochondrial	Mus musculus	4-9
7645027-3	1995	The MT-TG mice had 50% more Zn in liver and 300% more Zn in pancreas than control mice.	Zinc	54-56	tRNA glycine, mitochondrial	Mus musculus	4-9
7718580-2	1995	The kinetic reactivities of Zn(II) complexes of MT-3 with the chelator ethylenediaminetetraacetic acid (EDTA) or the thiol reagent dithiobis(2-nitrobenzoic acid) (DTNB) resembles the reactivity of ZnMT-1.	Zinc	28-34	metallothionein 3	Homo sapiens	48-52
7718580-3	1995	Furthermore, the candidate alpha and beta domain peptides of human MT-3 are very similar to MT-1 domain peptides in the reactivity of Zn(II) complexes.	Zinc	134-140	metallothionein 3	Homo sapiens	67-71
7617542-0	1995	Effects of teratogenic exposures to Zn2+, Cd2+, Ni2+, Co2+, and Cu2+ on metallothionein and metallothionein-mRNA contents of Xenopus embryos.	Zinc	36-40	metallothionein 4 L homeolog	Xenopus laevis	72-87
7617542-0	1995	Effects of teratogenic exposures to Zn2+, Cd2+, Ni2+, Co2+, and Cu2+ on metallothionein and metallothionein-mRNA contents of Xenopus embryos.	Zinc	36-40	metallothionein 4 L homeolog	Xenopus laevis	92-107
7617542-5	1995	Exposure-response curves (Cd2+, 1-18 microM; Zn2+, 3-300 microM) indicated that Cd2+ was 3- to 5-times more potent than Zn2+, based on metallothionein-mRNA response at stage 36 and metallothionein response at stage 46.	Zinc	120-124	metallothionein 4 L homeolog	Xenopus laevis	135-150
7617542-5	1995	Exposure-response curves (Cd2+, 1-18 microM; Zn2+, 3-300 microM) indicated that Cd2+ was 3- to 5-times more potent than Zn2+, based on metallothionein-mRNA response at stage 36 and metallothionein response at stage 46.	Zinc	120-124	metallothionein 4 L homeolog	Xenopus laevis	181-196
7923440-5	1994	Increasing the concentration of Zn in the bovine serum albumin (BSA)-containing culture medium up to 50 microM significantly increased MT-I levels by up to 3.5-fold in neurons and 2.5-fold in astrocytes.	Zinc	32-34	albumin	Rattus norvegicus	49-62
7965838-26	1994	We conclude that the naturally occurring large synaptic potentials in young CA3 neurones are apparently induced by endogenous Zn2+ which can promote or synchronize the release of GABA in the immature hippocampus.	Zinc	126-130	carbonic anhydrase 3	Rattus norvegicus	76-79
7970873-8	1994	The reduced production of IL-4 and IFN-gamma, the reduced peripheral eosinophilia and reduced serum levels of IgE and IgG1 in Zn- mice were attributed to the zinc deficiency, whereas the reduced delayed type hypersensitivity response to parasite antigen and reduced production of IL-5 were in certain instances attributed to reduced energy intake rather than zinc deficiency.	Zinc	126-128	LOC105243590	Mus musculus	118-122
7517167-13	1994	This is associated with an increase in hMT and reduction in host weight loss, suggesting a flow of Zn from the resorbing tumor to the host, enabling the synthesis of hMT and retention of host structural proteins.	Zinc	99-101	histamine N-methyltransferase	Homo sapiens	39-42
7517167-13	1994	This is associated with an increase in hMT and reduction in host weight loss, suggesting a flow of Zn from the resorbing tumor to the host, enabling the synthesis of hMT and retention of host structural proteins.	Zinc	99-101	histamine N-methyltransferase	Homo sapiens	166-169
8413301-11	1993	When Cd and Zn are added to cultures of MEAN-RA in the absence of DMSO, ALAS-2 is induced but erythroid differentiation does not occur and cells continue to grow normally.	Zinc	12-14	aminolevulinic acid synthase 2, erythroid	Mus musculus	72-78
8413301-14	1993	In cultures of MEAN-RA where ALAS-2 had been induced with Cd plus Zn 24 h prior to DMSO addition, onset of heme synthesis occurs more rapidly than when DMSO and Cd plus Zn are added simultaneously.	Zinc	66-68	aminolevulinic acid synthase 2, erythroid	Mus musculus	29-35
8413301-14	1993	In cultures of MEAN-RA where ALAS-2 had been induced with Cd plus Zn 24 h prior to DMSO addition, onset of heme synthesis occurs more rapidly than when DMSO and Cd plus Zn are added simultaneously.	Zinc	169-171	aminolevulinic acid synthase 2, erythroid	Mus musculus	29-35
8142006-8	1993	Increasing Zn(II) also decreases Km(app) and Vm for both glucose and UDP-galactose in the lactose synthase reaction with either both Ca(II)- or apo-alpha-lactalbumin, further suggesting novel interactions between Zn(II)-alpha-lactalbumin and the lactose synthase complex, presumably mediated via a Zn(II)-induced conformational change upon binding to alpha-lactalbumin.	Zinc	11-13	carbonic anhydrase 2	Homo sapiens	133-140
8393252-4	1993	While the dUTPase was not completely dependent on the addition of divalent cations, its activity was stimulated markedly by Zn2+, Mg2+, and Mn2+.	Zinc	124-128	Deoxyuridine triphosphatase	Drosophila melanogaster	10-17
8494609-14	1993	Cd2+ and Zn2+ induced XlMT-A mRNA in all tissues examined (kidney, spleen, heart, intestine, testes, and brain).	Zinc	9-13	metallothionein 4 L homeolog	Xenopus laevis	22-28
8497866-2	1993	Although Cd and Zn induce both p70 and MTs, Co induces only p70.	Zinc	16-18	annexin A6	Homo sapiens	31-34
8463315-5	1993	The role of this site in catalysis was examined by mutating one of the presumptive Zn(2+)-coordinating histidines (His108) in human insulin-degrading enzyme to leucine or glutamine, which were predicted to reduce or eliminate Zn2+ binding without substantially altering secondary structure.	Zinc	83-89	insulin degrading enzyme	Homo sapiens	132-156
8463315-5	1993	The role of this site in catalysis was examined by mutating one of the presumptive Zn(2+)-coordinating histidines (His108) in human insulin-degrading enzyme to leucine or glutamine, which were predicted to reduce or eliminate Zn2+ binding without substantially altering secondary structure.	Zinc	226-230	insulin degrading enzyme	Homo sapiens	132-156
8463315-10	1993	These results suggest that an intact Zn(2+)-binding domain in human insulin-degrading enzyme is required for catalytic activity and can affect, but is not required for, substrate binding.	Zinc	37-43	insulin degrading enzyme	Homo sapiens	68-92
8428956-5	1993	Its responsiveness toward the usual PTP activators (e.g. spermine) or inhibitors (e.g. vanadate, molybdate, heparin, or Zn2+) varied considerably with the nature of the substrates involved.	Zinc	120-124	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	36-39
8424649-1	1993	Porphobilinogen synthase (PBGS) is essential to all life forms; in mammals it is definitively established that Zn(II) is required for activity.	Zinc	111-117	aminolevulinate dehydratase	Homo sapiens	26-30
8424649-5	1993	Proton-induced X-ray emission analysis shows E. coli PBGS to contain a stoichiometric amount of Zn and no other metals.	Zinc	96-98	aminolevulinate dehydratase	Homo sapiens	53-57
8424649-8	1993	We conclude from these data that E. coli PBGS is a Zn(II)-metalloenzyme and that Zn(II) is required for catalytic activity, and propose that the mammalian and bacterial PBGS function by similar mechanisms.	Zinc	51-57	aminolevulinate dehydratase	Homo sapiens	41-45
8424649-10	1993	For E. coli PBGS, Mg(II) causes a twofold stimulation of the Zn(II)-induced E. coli PBGS activity; this effect is not seen for bovine PBGS.	Zinc	61-67	aminolevulinate dehydratase	Homo sapiens	12-16
8424649-10	1993	For E. coli PBGS, Mg(II) causes a twofold stimulation of the Zn(II)-induced E. coli PBGS activity; this effect is not seen for bovine PBGS.	Zinc	61-67	aminolevulinate dehydratase	Homo sapiens	84-88
8424649-10	1993	For E. coli PBGS, Mg(II) causes a twofold stimulation of the Zn(II)-induced E. coli PBGS activity; this effect is not seen for bovine PBGS.	Zinc	61-67	aminolevulinate dehydratase	Homo sapiens	84-88
1303761-4	1992	This shows that Cd-substituted GAL4 is destabilized relative to the native Zn-containing protein.	Zinc	75-77	galectin 4	Homo sapiens	31-35
1333766-11	1992	The maximum activity of Mn-SOD was found to be about 4 times higher than that of Cu, Zn-SOD after hepatectomy.	Zinc	85-87	superoxide dismutase 2	Rattus norvegicus	24-30
1449602-1	1992	The primary structure of carboxypeptidase T--a Zn-dependent extracellular enzyme of Thermoactinomyces vulgaris--was determined from the cloned cpT gene nucleotide sequence and compared to Zn-carboxypeptidases from various organisms.	Zinc	47-49	choline phosphotransferase 1	Homo sapiens	143-146
1426532-0	1992	Interaction of Zn2+ and Cu2+ ions with glyceraldehyde-3-phosphate dehydrogenase from bovine heart and rabbit muscle.	Zinc	15-19	LOC786101	Bos taurus	39-79
1426532-8	1992	The association constant for GAPDH-Zn2+ complex, calculated from equilibrium dialysis data, was 0.9 x 10(4) M-1 for the bovine heart GAPDH and 1.3 x 10(4) M-1 for the rabbit muscle enzyme.	Zinc	35-39	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	29-34
1426532-8	1992	The association constant for GAPDH-Zn2+ complex, calculated from equilibrium dialysis data, was 0.9 x 10(4) M-1 for the bovine heart GAPDH and 1.3 x 10(4) M-1 for the rabbit muscle enzyme.	Zinc	35-39	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	133-138
1426532-15	1992	It is discussed if Zn2+ ions could have a kind of modulation effect on GAPDH activity.	Zinc	19-23	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	71-76
1379555-1	1992	Tyrosine phosphorylation of p60c-src induced by Zn2+ in rat hippocampal membranes is shown to inhibit Src tyrosine kinase activity.	Zinc	48-52	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	33-36
1379555-1	1992	Tyrosine phosphorylation of p60c-src induced by Zn2+ in rat hippocampal membranes is shown to inhibit Src tyrosine kinase activity.	Zinc	48-52	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	102-105
1379555-2	1992	Zn2+ catalyzes the phosphorylation of p60c-src in the membranes but does not activate autophosphorylation of p60c-src immunoprecipitated with anti-Src monoclonal antibody.	Zinc	0-4	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	43-46
1335503-10	1992	Cd2+, Zn2+ and La3+ produced block of INa at low concentrations that was nearly voltage independent with z" &lt; or = 0.13.	Zinc	6-10	internexin neuronal intermediate filament protein alpha	Canis lupus familiaris	38-41
1335503-11	1992	Fits of single-site binding curves to peak INa in response to step depolarizations at positive test potentials gave the following apparent KD values: Zn2+ 0.14 mM, Cd2+ 0.27 mM and La3+ 0.50 mM.	Zinc	150-153	internexin neuronal intermediate filament protein alpha	Canis lupus familiaris	43-46
1639922-6	1992	By frontal analyses, immobilized HRG peptides of the type (GHHPH)nG, where n = 1-3, were each found to have a similar binding capacity for both Cu(II) ions and Zn(II) ions (31-38 mumol/ml gel).	Zinc	160-166	histidine rich glycoprotein	Homo sapiens	33-36
1597188-11	1992	PG-9-KR contains 1.9 mol Zn2+/mol enzyme and no other cofactors.	Zinc	25-29	carbonyl reductase [NADPH] 1	Sus scrofa	0-7
1883844-5	1991	CNTF was purified to homogeneity from cell lysates via anion-exchange, cation-exchange and Zn(2+)-affinity chromatography.	Zinc	91-97	ciliary neurotrophic factor	Homo sapiens	0-4
1998669-0	1991	Effect of Zn2+ on the thermal denaturation of carboxypeptidase B.	Zinc	10-14	carboxypeptidase B1	Homo sapiens	46-64
2205855-8	1990	The increased expression of the GH receptor by Zn2+ was associated with an increased magnitude of GH-stimulated insulin biosynthesis.	Zinc	47-51	growth hormone receptor	Rattus norvegicus	32-43
2202952-5	1990	In contrast, morphologic transformation develops more slowly and does not appear until 72-96 h after Zn++ stimulation in cells with very low basal levels of activated p21 (MR4 cells) and 24-48 h in cells with higher basal levels (MR5 cells).	Zinc	101-105	KRAS proto-oncogene, GTPase	Rattus norvegicus	167-170
2162357-6	1990	With reduced carboxamidomethylated and maleylated lysozyme as substrate, CD45 was stimulated up to 12-fold by basic compounds such as spermine; divalent metal ions were also stimulatory, most notably Zn2+, which was previously identified as a potent inhibitor of the low Mr PTPases.	Zinc	200-204	protein tyrosine phosphatase receptor type C	Homo sapiens	73-77
2107541-1	1990	The DNA-binding domain of the transcription factor GAL4, consisting of the 62 N-terminal residues and denoted GAL4(62*), contains a Cys-Xaa2-Cys-Xaa6-Cys-Xaa6-Cys-Xaa2-Cys-Xaa6+ ++-Cys motif, which has been shown previously to bind two Zn(II) or Cd(II) ions.	Zinc	236-238	galectin 4	Homo sapiens	51-55
2110867-3	1990	Of these metals, Zn2+ and Cd2+ (20 microM) caused a remarkable increase in hepatic microsomal beta-glucuronidase activity.	Zinc	17-21	glucuronidase, beta	Rattus norvegicus	94-112
2110867-4	1990	Appreciable effects of Zn2+ and Cd2+ on beta-glucuronidase activity were seen at 5.0 microM, and the effects were saturated at 50 microM.	Zinc	23-27	glucuronidase, beta	Rattus norvegicus	40-58
2110867-6	1990	Thus, Zn2+ and Cd2+ uniquely increased beta-glucuronidase activity.	Zinc	6-10	glucuronidase, beta	Rattus norvegicus	39-57
2110867-7	1990	The Zn2(+)- and Cd2(+)-induced increase in beta-glucuronidase activity was completely reversed by the presence of an SH group-protecting reagent (dithiothreitol).	Zinc	4-7	glucuronidase, beta	Rattus norvegicus	43-61
2110867-9	1990	The present study suggests that, of various metals tested, Zn2+ and Cd2+ can uniquely increase hepatic microsomal beta-glucuronidase activity and that their effect is based on binding to membranous SH groups, beside the enzyme protein.	Zinc	59-63	glucuronidase, beta	Rattus norvegicus	114-132
2303396-9	1990	The concentration of several other minerals were lower in tissues of ST lambs: Cu in kidneys (P less than .10) and liver (P = .12); Zn (P less than .05) in liver, kidneys and lungs; and Mn in liver (P less than .05).	Zinc	132-134	somatotropin	Ovis aries	69-71
12741822-4	2003	In each polypeptide chain, the free alpha-amino nitrogen and carbonyl oxygen of the amino-terminal Ser residue coordinate to a Zn(2+) ion to form a five-membered chelate, and the syn-unidentate interaction of the Asp7 side chain with the Zn(2+) cation leads to the formation of a unique docking arrangement for helix capping.	Zinc	238-240	synemin	Homo sapiens	179-182
34798712-3	2022	Monoammonium phosphate (MAP) coating with biodegradable organic polymers and the addition of magnesium (Mg) - a nutrient with a synergistic effect on the uptake of P, zinc (Zn), and boron (B) - emerge as a smart strategy to applying these micronutrients uniformly in soils.	Zinc	173-175	MAX dimerization protein MGA	Homo sapiens	93-111
34911298-2	2021	Herein, a novel photoelectrochemical (PEC) biosensor was developed for the ultrasensitive and highly selective detection of microRNA-122 (miRNA-122) based on a direct Z-scheme heterojunction of Zn vacancy-mediated CdS/ZnS (CSZS-VZn).	Zinc	194-196	microRNA 122	Homo sapiens	124-136
34911298-2	2021	Herein, a novel photoelectrochemical (PEC) biosensor was developed for the ultrasensitive and highly selective detection of microRNA-122 (miRNA-122) based on a direct Z-scheme heterojunction of Zn vacancy-mediated CdS/ZnS (CSZS-VZn).	Zinc	194-196	microRNA 122	Homo sapiens	138-147
34913610-2	2022	Here, a novel paradigm of starvation therapy is proposed to synergize the "Zn2+ interference"-mediated glycolysis inhibition and Zn2+ -activating GLUT1 (Glucose transporter 1) tumor specific depletion for systematic energy exhaustion.	Zinc	129-133	solute carrier family 2 member 1	Homo sapiens	146-151
34913610-2	2022	Here, a novel paradigm of starvation therapy is proposed to synergize the "Zn2+ interference"-mediated glycolysis inhibition and Zn2+ -activating GLUT1 (Glucose transporter 1) tumor specific depletion for systematic energy exhaustion.	Zinc	129-133	solute carrier family 2 member 1	Homo sapiens	153-174
34913610-4	2022	Meanwhile, Zn2+ -activating DNAzymes for specifically cleaving GLUT1 mRNA is designed.	Zinc	11-15	solute carrier family 2 member 1	Homo sapiens	63-68
34731734-7	2021	Mechanistically, 20 micromol/L Zn enhanced tight junction protein markers including CLDN-1, OCLD, and ZO-1 both at protein and mRNA levels (P < 0.05), and also increased the level of phosphorylation of TOR protein (P < 0.05) and activated the TOR signaling pathway.	Zinc	31-33	claudin-1	Anas platyrhynchos	84-90
34757546-10	2022	Our results showed that Zn2+, Fe3+ and Fe2+ inhibited tPA-induced thrombolysis, with Zn2+ and Fe2+ being the most effective.	Zinc	24-28	chromosome 20 open reading frame 181	Homo sapiens	54-57
34757546-10	2022	Our results showed that Zn2+, Fe3+ and Fe2+ inhibited tPA-induced thrombolysis, with Zn2+ and Fe2+ being the most effective.	Zinc	85-89	chromosome 20 open reading frame 181	Homo sapiens	54-57
34750356-6	2021	Cocaine-induced increases in Zn2+ were dependent on the Zn2+ transporter 3 (ZnT3), a neuronal Zn2+ transporter localized to synaptic vesicle membranes, as ZnT3 knockout (KO) mice were insensitive to cocaine-induced increases in striatal Zn2+.	Zinc	29-33	solute carrier family 30 (zinc transporter), member 3	Mus musculus	56-74
34750356-6	2021	Cocaine-induced increases in Zn2+ were dependent on the Zn2+ transporter 3 (ZnT3), a neuronal Zn2+ transporter localized to synaptic vesicle membranes, as ZnT3 knockout (KO) mice were insensitive to cocaine-induced increases in striatal Zn2+.	Zinc	29-33	solute carrier family 30 (zinc transporter), member 3	Mus musculus	76-80
34750356-6	2021	Cocaine-induced increases in Zn2+ were dependent on the Zn2+ transporter 3 (ZnT3), a neuronal Zn2+ transporter localized to synaptic vesicle membranes, as ZnT3 knockout (KO) mice were insensitive to cocaine-induced increases in striatal Zn2+.	Zinc	94-98	solute carrier family 30 (zinc transporter), member 3	Mus musculus	56-74
34750356-6	2021	Cocaine-induced increases in Zn2+ were dependent on the Zn2+ transporter 3 (ZnT3), a neuronal Zn2+ transporter localized to synaptic vesicle membranes, as ZnT3 knockout (KO) mice were insensitive to cocaine-induced increases in striatal Zn2+.	Zinc	94-98	solute carrier family 30 (zinc transporter), member 3	Mus musculus	76-80
34791819-2	2021	The analysis of the XANES region of the measured spectra shows that Zn binds to BST2, as well as to orf7a, thus resulting in the formation of BST2-orf7a complexes.	Zinc	68-70	bone marrow stromal cell antigen 2	Homo sapiens	80-84
34791819-2	2021	The analysis of the XANES region of the measured spectra shows that Zn binds to BST2, as well as to orf7a, thus resulting in the formation of BST2-orf7a complexes.	Zinc	68-70	bone marrow stromal cell antigen 2	Homo sapiens	142-146
34791819-4	2021	Our explanation for this behavior is that, when BST2 gets in contact with Zn bound to the orf7a Cys15 ligand, it has the ability of displacing the metal owing to the creation of a new disulfide bridge across the two proteins.	Zinc	74-76	bone marrow stromal cell antigen 2	Homo sapiens	48-52
34161632-8	2021	A candidate gene association analysis further verified that GRMZM2G142870 and GRMZM2G045531 affect Zn and Mn accumulations, respectively.	Zinc	99-101	Zinc transporter 3	Zea mays	78-91
34559918-2	2021	The ZIP (ZRT, IRT-like Protein) family members are involved in Zn transport and cellular Zn homeostasis throughout the domains of life.	Zinc	63-65	Argonaute family protein	Arabidopsis thaliana	4-7
34559918-2	2021	The ZIP (ZRT, IRT-like Protein) family members are involved in Zn transport and cellular Zn homeostasis throughout the domains of life.	Zinc	89-91	Argonaute family protein	Arabidopsis thaliana	4-7
34559918-4	2021	The four ZIP proteins can restore the growth defect of a yeast Zn-uptake mutant and are up-regulated under Zn deficiency.	Zinc	63-65	Argonaute family protein	Arabidopsis thaliana	9-12
34559918-4	2021	The four ZIP proteins can restore the growth defect of a yeast Zn-uptake mutant and are up-regulated under Zn deficiency.	Zinc	107-109	Argonaute family protein	Arabidopsis thaliana	9-12
34559918-7	2021	All four ZIP genes are highly expressed during seed development, and siliques from all single and higher order mutants exhibited an increased number of abnormal seeds, and decreased Zn levels in mature seeds relative to wild type.	Zinc	182-184	Argonaute family protein	Arabidopsis thaliana	9-12
34559918-9	2021	Our data demonstrate that IRT3, ZIP4, ZIP6 and ZIP9 function redundantly in maintaining Zn homeostasis and seed development in A. thaliana.	Zinc	88-90	zinc transporter	Arabidopsis thaliana	32-36
34559918-9	2021	Our data demonstrate that IRT3, ZIP4, ZIP6 and ZIP9 function redundantly in maintaining Zn homeostasis and seed development in A. thaliana.	Zinc	88-90	ZIP metal ion transporter family	Arabidopsis thaliana	47-51
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	cAMP responsive element binding protein 1	Homo sapiens	47-84
34706747-9	2021	In addition, ZIP10 promoted Zn content-induced cAMP-response element binding protein (CREB) phosphorylation and activation, which are required for integrin alpha10 (ITGA10) transcription and ITGA10-mediated PI3K/AKT pathway activation.	Zinc	28-30	cAMP responsive element binding protein 1	Homo sapiens	86-90
34681235-8	2021	In addition, molecular modeling has also contributed largely to our understanding of Zn binding to NAP peptides.	Zinc	85-87	catenin beta like 1	Homo sapiens	99-102
34688329-4	2021	In this work, further characterization studies were performed, which confirmed that the ZnO/Ag nanoparticles were physically embedded and evenly distributed in the ZnO/Ag/PVP/PCL nanofibers, enabling the sustained release of Ag and Zn.	Zinc	232-234	PHD finger protein 1	Homo sapiens	175-178
34337745-4	2021	Additionally, the addition of 200 mM L-Ca and 6 mM L-Zn significantly improved the emulsifying capacity by 41.73% and 13.6%, the foaming capacity by 26.57% and 10%, and the protein solubility by 13.89% and 12.70%, respectively.	Zinc	53-55	protein tyrosine phosphatase receptor type C	Homo sapiens	37-41
34247649-5	2021	We further confirmed that induction of M2 polarization by Zn2+ was realized via PI3K/Akt/mTOR pathway, whereas marker molecules on this pathway were strictly regulated by the addition of Zn2+.	Zinc	58-62	mechanistic target of rapamycin kinase	Rattus norvegicus	89-93
34142156-4	2021	It is also reported that MUTYH has a Zn-binding motif in a unique interdomain connector (IDC) region, which interacts with Rad9-Rad1-Hus1 complex (9-1-1) in DNA damage response, and with apurinic/apyrimidinic endonuclease 1 (APE1) in BER.	Zinc	37-39	mutY DNA glycosylase	Homo sapiens	25-30
34142156-9	2021	The IDC, including the Zn-binding motif, is exposed on the MUTYH surface, suggesting its interaction modes with 9-1-1 and APE1, respectively.	Zinc	23-25	mutY DNA glycosylase	Homo sapiens	59-64
34060571-3	2021	Herein we reported Zn-doped Ni3S2 nanosheet arrays supported on Ni foam (Zn-Ni3S2/NF) that were synthesized by a two-step hydrothermal process for improving HER catalysis under alkaline conditions.	Zinc	19-21	neurofascin	Homo sapiens	82-84
34168809-3	2021	Here, we report a non-concentrated aqueous electrolyte composed of 2 m zinc trifluoromethanesulfonate (Zn(OTf)2) and the organic dimethyl carbonate (DMC) additive to stabilize the Zn electrochemistry.	Zinc	180-182	POU class 2 homeobox 2	Homo sapiens	105-111
34336605-6	2021	Methods: In this assay, a biotinylated peptide was used as a G9a substrate in conjugation with streptavidin-coated ZnS/CdSe QD as FRET acceptor, and an anti-mark antibody labeled with Tb as a donor.	Zinc	115-118	euchromatic histone lysine methyltransferase 2	Homo sapiens	61-64
35358383-6	2022	As a test of this possibility, NB2 was used to prepare an unprecedented Zn complex containing 7 Zn2+ metal centers connected by a network of bridging atoms, as confirmed by a single crystal X-ray diffraction analysis.	Zinc	72-74	contactin 5	Homo sapiens	31-34
35358383-6	2022	As a test of this possibility, NB2 was used to prepare an unprecedented Zn complex containing 7 Zn2+ metal centers connected by a network of bridging atoms, as confirmed by a single crystal X-ray diffraction analysis.	Zinc	96-100	contactin 5	Homo sapiens	31-34
35460952-9	2022	The association for mPC4 (reflecting HDL subclasses) was positive for Sb, but inverse for plasma Zn.	Zinc	97-99	proprotein convertase subtilisin/kexin type 4	Mus musculus	20-24
35588279-2	2022	Herein, an enamel-like layer of nanohydroxyapatite (Ca5(PO4)3(OH), nano-HAP) is constructed on Zn anode to enhance its stability.	Zinc	95-97	carbonic anhydrase 5A	Homo sapiens	52-61
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	Sed1p	Saccharomyces cerevisiae S288C	33-37
35405529-10	2022	From this panel, we selected the SED1, GDI1 and ZRT1 genes for validation by qRT-PCR and discovered that, during Zn2+ and Ni2+ stress, SED1 and GDI1 were upregulated, while ZRT1 was downregulated, which was consistent with the RNA-Seq results and the biochemical function of these genes.	Zinc	113-117	Sed1p	Saccharomyces cerevisiae S288C	135-139
35574354-12	2022	Zn2+ and the Glu402 and Gly186 residues of MMP9 are important for its interaction with GA-Me.	Zinc	0-4	matrix metallopeptidase 9	Homo sapiens	43-47
35120972-8	2022	The sensor has been used to assess Zn2+ in river, waste, tap, sea, well, and spring waters samples, serum of diabetic patients, powdered milk, hair, red meat, pharmaceutical formulations, and talc powder samples.	Zinc	35-39	nuclear RNA export factor 1	Homo sapiens	57-60
35559413-9	2022	The concentrations of Ca2+, Mg2+, Zn2+, and K+ increased in TGF-beta1- and TGF-beta2-treated ARPE-19 cells, while the concentration of Na+ decreased.	Zinc	34-38	transforming growth factor beta 2	Homo sapiens	75-84
35559413-14	2022	In the TGF-beta2 treatment group, the Ca2+, Mg2+, Zn2+, and K+ concentrations were also upregulated and reached their highest after 72, 72, 72, and 36 h, respectively.	Zinc	50-54	transforming growth factor beta 2	Homo sapiens	7-16
35287434-2	2022	Herein, we present the stabilization effect of Ag+- and Zn2+-exchanged zeolite A (denoted as Ag-A and Zn-A, respectively) on the resin-dentin bonding interface.	Zinc	56-60	aspartylglucosaminidase	Mus musculus	93-97
35050500-3	2022	Among the natural thiamine compounds, thiamine triphosphate (ThTP) is the best effector of recombinant human PdxK (hPdxK) in vitro, inhibiting hPdxK in the presence of Mg2+ , but activating the Zn2+ -dependent reaction.	Zinc	194-198	pyridoxal kinase	Homo sapiens	109-113
35050500-3	2022	Among the natural thiamine compounds, thiamine triphosphate (ThTP) is the best effector of recombinant human PdxK (hPdxK) in vitro, inhibiting hPdxK in the presence of Mg2+ , but activating the Zn2+ -dependent reaction.	Zinc	194-198	pyridoxal kinase	Homo sapiens	115-120
35050500-3	2022	Among the natural thiamine compounds, thiamine triphosphate (ThTP) is the best effector of recombinant human PdxK (hPdxK) in vitro, inhibiting hPdxK in the presence of Mg2+ , but activating the Zn2+ -dependent reaction.	Zinc	194-198	pyridoxal kinase	Homo sapiens	143-148
35258182-2	2022	A total of 16 heavy metal elements (Al, Si, K, Ca, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Ba, Pb, and Cd) in PM1 were continuously determined by an online heavy metal observation instrument in Zhengzhou city from January 7 to 25, 2021.	Zinc	74-76	transmembrane protein 11	Homo sapiens	105-108
35077646-7	2022	In addition, the metal-binding proteins parvalbumin-alpha and carbonic anhydrase 2 were detected, identified, and imaged in their native form, i.e., parvalbumin-alpha + 2Ca2+ and carbonic anhydrase + Zn2+.	Zinc	200-204	parvalbumin	Rattus norvegicus	40-57
35077646-7	2022	In addition, the metal-binding proteins parvalbumin-alpha and carbonic anhydrase 2 were detected, identified, and imaged in their native form, i.e., parvalbumin-alpha + 2Ca2+ and carbonic anhydrase + Zn2+.	Zinc	200-204	parvalbumin	Rattus norvegicus	149-166
35095413-6	2021	of Zn2+ dose-dependently induced acute itch and transient receptor potential A1 (TRPA1) participated in Zn2+-induced acute itch in mice.	Zinc	104-108	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	48-79
35095413-6	2021	of Zn2+ dose-dependently induced acute itch and transient receptor potential A1 (TRPA1) participated in Zn2+-induced acute itch in mice.	Zinc	104-108	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	81-86
34934014-5	2022	Focusing on striatal neurons, we show that the dominant isoform KCTD5 exerts its effects through an unusual mechanism that modulates the influx of Zn2+ via the Zip14 transporter to exert unique allosteric effects on AC.	Zinc	147-151	potassium channel tetramerisation domain containing 5	Mus musculus	64-69
34934014-7	2022	Finally, we report that KCTD5 haploinsufficiency in mice leads to motor deficits that can be reversed by chelating Zn2+ Together, our findings uncover KCTD proteins as major regulators of neuronal cAMP signaling via diverse mechanisms.	Zinc	115-119	potassium channel tetramerisation domain containing 5	Mus musculus	24-29
35296207-12	2022	In conclusion, an increase of p67phox expression in response to Zn2+ is an intrinsic adaptive response to I/R and leads to cardioprotection against I/R by upregulating ZIP2 via STAT3.	Zinc	64-68	solute carrier family 39 (zinc transporter), member 2	Mus musculus	168-172
35224154-2	2022	HRGP ligands includes heme, Zn2+, thrombospondin, plasmin/plasminogen, heparin/heparan sulfate, fibrinogen, tropomyosin, IgG, FcgammaR, C1q.	Zinc	28-32	histidine rich glycoprotein	Homo sapiens	0-4
35224154-3	2022	In many conditions, the histidine-rich region of HRGP strengthens ligand binding following interaction with Zn2+ or exposure to low pH, such as sites of tissue injury or tumor growth.	Zinc	108-112	histidine rich glycoprotein	Homo sapiens	49-53
35224154-6	2022	The most common cell surface ligand of HRGP is heparan sulfate proteoglycan, and the interaction is also potentiated by elevated Zn2+ concentration and low pH.	Zinc	129-133	histidine rich glycoprotein	Homo sapiens	39-43
2480518-6	1989	In the second approach we transfected 10T1/2 cells with a Mt-anti-sense c-H-ras construct which reduced p21 expression, slowed the growth rate and altered the morphology of 10T1/2 cells when induced with Zn.	Zinc	204-206	Harvey rat sarcoma virus oncogene	Mus musculus	72-79
2480518-6	1989	In the second approach we transfected 10T1/2 cells with a Mt-anti-sense c-H-ras construct which reduced p21 expression, slowed the growth rate and altered the morphology of 10T1/2 cells when induced with Zn.	Zinc	204-206	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	104-107
2480518-7	1989	Surprisingly, the decrease in p21 ras levels by both approaches caused a marked increase in NK susceptibility (NKS) which was equivalent to that observed when the p21 ras levels were increased either by inducing EJ-ras or removing Zn2+ from Mt-anti-sense c-H-ras containing cells.	Zinc	231-235	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	30-33
2500271-9	1989	After administration of both B6-HCl and B6-P and withdrawal of VPA, the overall increase in ALA-D was from 54.59 to 197.2 U (-Zn; -DTT) and from 50.76 to 217.3 U (+Zn; +DTT).	Zinc	126-128	plakophilin 1	Homo sapiens	40-44
2500271-9	1989	After administration of both B6-HCl and B6-P and withdrawal of VPA, the overall increase in ALA-D was from 54.59 to 197.2 U (-Zn; -DTT) and from 50.76 to 217.3 U (+Zn; +DTT).	Zinc	126-128	aminolevulinate dehydratase	Homo sapiens	92-97
2500271-9	1989	After administration of both B6-HCl and B6-P and withdrawal of VPA, the overall increase in ALA-D was from 54.59 to 197.2 U (-Zn; -DTT) and from 50.76 to 217.3 U (+Zn; +DTT).	Zinc	164-166	plakophilin 1	Homo sapiens	40-44
2500271-9	1989	After administration of both B6-HCl and B6-P and withdrawal of VPA, the overall increase in ALA-D was from 54.59 to 197.2 U (-Zn; -DTT) and from 50.76 to 217.3 U (+Zn; +DTT).	Zinc	164-166	aminolevulinate dehydratase	Homo sapiens	92-97
2721488-3	1989	The v-mos transformed cells expressed mos mRNA at an amount proportional to the concentration of Zn2+ ions.	Zinc	97-101	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	6-9
2721488-3	1989	The v-mos transformed cells expressed mos mRNA at an amount proportional to the concentration of Zn2+ ions.	Zinc	97-101	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	38-41
2851333-0	1988	Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II.	Zinc	79-83	carbonic anhydrase 2	Homo sapiens	120-141
2849438-2	1988	The apoprotein of metallothionein as well as the peptide LYS-CYS-THR-CYS-CYS-ALA exert a strong inhibitory effect upon pyridoxal kinase by sequestering free Zn ions.	Zinc	157-159	pyridoxal kinase	Homo sapiens	119-135
2849438-3	1988	Several steps intervene in the process of pyridoxal kinase activation, i.e. binding of Zn ions by ATP and interaction of Zn-ATP with the enzyme; but direct interaction between metallothionein and pyridoxal kinase (protein association) could not be detected by emission anisotropy measurements.	Zinc	87-89	pyridoxal kinase	Homo sapiens	42-58
2849438-4	1988	Since the concentration of free Zn++ in mammalian tissues is lower than 10(-9)M, it is postulated that the concentration of metallothionein regulates the catalytic activity of pyridoxal kinase.	Zinc	32-36	pyridoxal kinase	Homo sapiens	176-192
3411389-7	1988	Retention of Zn for the study group went from -21.2 +/- 46.7 in period 1 to 204.5 +/- 103.0 micrograms/kg/day in period 2 (p less than 0.0001), and fecal weight decreased from 70.5 +/- 20.6 in period 1 to 36.8 +/- 20.0 gm/kg/day in period 2.	Zinc	13-15	period circadian regulator 2	Homo sapiens	113-121
3411389-9	1988	Plasma mean Cu and Zn levels were low in period 1 but rose in period 2, especially for Zn.	Zinc	19-21	period circadian regulator 2	Homo sapiens	62-70
2843387-4	1988	In contrast, Cd2+, Hg2+, Mg2+, Ni2+ and Zn2+ inhibited binding at all concentrations tested.	Zinc	40-44	Cd2 molecule	Rattus norvegicus	13-16
3187934-3	1988	Zn(II) (10-50 microM) decreases the elastic modulus of those gels, even in the presence of a large excess of Ca(II).	Zinc	0-6	carbonic anhydrase 2	Homo sapiens	109-115
3376901-5	1988	We hypothesize that the increase in plasma retinol levels noted in the preterm infants receiving Zn supplementation may be mediated by an increased production of RBP in the liver that in turn enhances the hepatic release of retinol.	Zinc	97-99	retinol binding protein 4	Homo sapiens	162-165
3689799-1	1987	A prothrombin activator from the venom of Bothrops neuwiedi was purified by gel filtration on Sephadex G-100, ion-exchange chromatography on DEAE-Sephacel and affinity chromatography on a Zn2+-chelate column.	Zinc	188-192	coagulation factor II, thrombin	Bos taurus	2-13
2821539-8	1987	Both rEC-SOD and nEC-SOD contained 4 Cu and 4 Zn atoms per molecule, and the presence of Zn in EC-SOD is thus now established.	Zinc	46-48	superoxide dismutase 3	Rattus norvegicus	5-12
3113477-1	1987	The effect of divalent metal ions on the rate of dextran sulfate dependent autocatalytic activation of human blood coagulation factor XII was studied at pH 7.4 and 25 degrees C. Zn2+ and Cu2+, but not Co2+, increased the rate of factor XII activation induced by dextran sulfate with optimum effects at approximately 5 and 1 microM, respectively, while Ca2+ acceleration required much higher concentrations (millimolar).	Zinc	178-182	coagulation factor XII	Homo sapiens	115-137
3790546-1	1986	The fluorescence of alcohol dehydrogenase is quenched by the acid dissociation of some group on the protein having an apparent pKa of 9.6 at 25 degrees C. The pKa of this alkaline quenching transition is unchanged by the binding of trifluoroethanol or pyrazole to the enzyme or by the selective removal of the active site of Zn2+ ion.	Zinc	325-329	aldo-keto reductase family 1 member A1	Homo sapiens	20-41
3086246-2	1986	In the present paper, response changes in Zn biodistribution (mice) and Zn excretion through the pancreatic duct (rats) due to the stimulation of gastro-intestinal hormones like secretin, CCK-PZ (exocrine stimulation) and glucose (endocrine stimulation) were studied.	Zinc	42-44	cholecystokinin	Mus musculus	188-191
2989649-0	1985	Modulation of the cardiac membrane-bound cyclic nucleotide phosphodiesterase: inhibition due to a contamination of TLC purified S-adenosyl-L-[methyl-3H] methionine by Zn++ ions.	Zinc	167-171	phosphodiesterase 3B	Homo sapiens	41-76
2989649-4	1985	The contaminating Zn++ ions strongly inhibited cyclic nucleotide phosphodiesterase activity and phospholipid methylation with I50 values in the micromolar range.	Zinc	18-22	phosphodiesterase 3B	Homo sapiens	47-82
6327912-2	1984	Neurotensin degradation by rabbit brain cystosol fractions was activated by dithiothreitol and inhibited by thiol blocking reagents, Zn2+, and by monospecific antibodies against endo- oligopeptidases A and B, thus suggesting the possible involvement of these enzymes in neurotensin degradation by rabbit brain.	Zinc	133-137	neurotensin/neuromedin N	Oryctolagus cuniculus	0-11
6372518-6	1984	Zn2+ and CO2+ inhibited the glucose-stimulated insulin release from microdissected perifused islets.	Zinc	0-4	insulin	Canis lupus familiaris	47-54
6372518-8	1984	Zn2+ also inhibited K+-induced insulin release in the absence of glucose, indicating that Zn2+ inhibition does not involve glucose metabolism.	Zinc	0-4	insulin	Canis lupus familiaris	31-38
6321177-9	1984	This feature could mean that optimal binding of the Zn atom present in the catalytic site is a more stringent requirement in angiotensin-converting enzyme than in enkephalinase.	Zinc	52-54	membrane metallo-endopeptidase	Rattus norvegicus	163-176
6314846-3	1983	Potentiometric, visible, infrared, electron spin, and nuclear magnetic resonance studies of the complexation of N-(2-acetamido)iminodiacetic acid (H2ADA) by Ca(II), Mg(II), Mn(II), Zn(II), Co(II), Ni(II), and Cu(II) are reported.	Zinc	181-187	carbonic anhydrase 2	Homo sapiens	157-163
6857700-7	1983	These results are consistent with the hypothesis that R40F cells express Cd2+ and Zn2+ resistance as a consequence of a reduction in unbound intracellular Cd2+ levels and an elevation of metallothionein synthesis.	Zinc	82-86	T-cell surface antigen CD2	Cricetulus griseus	155-158
7287759-6	1981	Experiments carried out under essentially metal ion-free conditions have established directly that micromolar concentrations Of Zn2+, Cu2+, and Cd2+ inhibit carbamyl phosphate synthetase I.	Zinc	128-132	carbamoyl-phosphate synthase 1	Rattus norvegicus	157-188
6798328-14	1981	It may be noted that all of the effectors studied were chelating agents of divalent metals and the changes which they induced in the enzyme activities examined may be explained by interference of the chelates formed with metal cations, such as Zn++, co-factors or effectors of these glycolysis enzymes (with the exception of GPI).	Zinc	244-248	glucose-6-phosphate isomerase	Sus scrofa	325-328
7428106-2	1980	The ionic stoichiometries between Hg2+-binding and the release of Cd2+ (or Zn2+) and copper are 3 : 2 and 1 : 1 respectively.	Zinc	75-79	Cd2 molecule	Rattus norvegicus	66-69
7210007-8	1980	Disrupted cellular colonies with severe cell damage were observed after addition of 10(-3) M Cd2+ or Hg2+ as CdCl2 or HgCl2 while similar toxicity was observed only after addition of 10(-2) M Zn2+ or Cu2+ as ZnSO4 or CuSO4 to confluent cell cultures.	Zinc	192-196	Cd2 molecule	Rattus norvegicus	93-96
488038-3	1979	Intravenous injection of Cd2+ to the pregnant rat on day 12 causes a dose-dependent inhibition of placental Zn2+ transport.	Zinc	108-112	Cd2 molecule	Rattus norvegicus	25-28
488038-6	1979	At 20 hr after administration of Cd2+ the embryonic concentration of Zn2+ is depressed by 33%.	Zinc	69-73	Cd2 molecule	Rattus norvegicus	33-36
11449-0	1976	CD studies on the conformation of oligonucleotides complexed with divalent metal ions: interaction of Zn2+ with guanine favours syn conformation.	Zinc	102-106	synemin	Homo sapiens	128-131
1156386-1	1975	The addition of Zn2+ to human carbonic anhydrase B holoenzyme was shown to enhance the protein fluorescence, and this enhancement was correlated with the inhibition of the p-nitrophenyl acetate esterase activity.	Zinc	16-20	carbonic anhydrase 2	Homo sapiens	30-50
1156386-3	1975	A similar fluorescence enhancement was observed when Zn2+ was added to human carbonic anhydrase C and to bovine carbonic anhydrase, demonstrating that the binding site is not a thiol group.	Zinc	53-57	carbonic anhydrase 2	Homo sapiens	77-97
33872833-8	2021	The mRNA levels of ZRT1 and ZAP1 decreased in mtm1Delta cells contributing to less Zn uptake.	Zinc	83-85	Zap1p	Saccharomyces cerevisiae S288C	28-32
33609831-4	2021	In period 10, compared to the control group (CK), the adsorption capacity of Cu and Zn increased by 72.00% and 44.55%, respectively, and the number of oxygen-containing functional groups -OH, -COOH and -C=O greatly increased.	Zinc	84-86	cytidine/uridine monophosphate kinase 1	Homo sapiens	45-47
33756290-9	2021	In this study, the CV values of Cr in Factor 1, Cu, Zn, and Ni in Factor 2, Hg, and As in Factor 3, Pb, and Cd in Factor 4 were lower, indicates a lower deviation degree.	Zinc	52-54	transcription termination factor 2	Homo sapiens	66-74
34028036-8	2021	A candidate gene association analysis further verified that GRMZM2G142870 and GRMZM2G045531 affect Zn and Mn accumulations, respectively.	Zinc	99-101	Zinc transporter 3	Zea mays	78-91
33714765-4	2021	Local regulation in response to changes in cellular Zn status is based on the transcription factors bZIP19 and bZIP23, which sense changes in free Zn2+ concentrations in the cell.	Zinc	52-54	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	100-106
33714765-4	2021	Local regulation in response to changes in cellular Zn status is based on the transcription factors bZIP19 and bZIP23, which sense changes in free Zn2+ concentrations in the cell.	Zinc	52-54	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	111-117
33714765-4	2021	Local regulation in response to changes in cellular Zn status is based on the transcription factors bZIP19 and bZIP23, which sense changes in free Zn2+ concentrations in the cell.	Zinc	147-151	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	100-106
33714765-4	2021	Local regulation in response to changes in cellular Zn status is based on the transcription factors bZIP19 and bZIP23, which sense changes in free Zn2+ concentrations in the cell.	Zinc	147-151	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	111-117
33791795-7	2021	The most relevant intermolecular interactions in Zn2+-PBGS are due to the amino acids CYS0122, CYS0124, CYS0132, ASP0169, SER0168, ARG0221, HIS0131, ASP0120, GLY0133, VAL0121, ARG0209, and ARG0174.	Zinc	49-53	aminolevulinate dehydratase	Homo sapiens	54-58
33959626-6	2021	In a mouse model of atherosclerosis employing Ldlr -/- mice, intravenous administration of scFv-anti-LDL(-)-MCMN-Zn nanoformulation inhibited atherosclerosis progression without affecting vascular permeability or inducing leukocytes-endothelium interactions.	Zinc	113-115	low density lipoprotein receptor	Mus musculus	46-50
33577819-6	2021	Zn2+ binding sites were predicted in the TDP-43"s N-terminal domain, in the linker region between RRM1 and RRM2 domain, within RRM2 domain and at the junction of the RRM2 and C-terminal domain (CTD), but none in the 311-360 region of CTD.	Zinc	0-4	ribonucleotide reductase M2	Mus musculus	107-111
33577819-6	2021	Zn2+ binding sites were predicted in the TDP-43"s N-terminal domain, in the linker region between RRM1 and RRM2 domain, within RRM2 domain and at the junction of the RRM2 and C-terminal domain (CTD), but none in the 311-360 region of CTD.	Zinc	0-4	ribonucleotide reductase M2	Mus musculus	127-131
33577819-6	2021	Zn2+ binding sites were predicted in the TDP-43"s N-terminal domain, in the linker region between RRM1 and RRM2 domain, within RRM2 domain and at the junction of the RRM2 and C-terminal domain (CTD), but none in the 311-360 region of CTD.	Zinc	0-4	ribonucleotide reductase M2	Mus musculus	127-131
33577819-7	2021	Furthermore, we found that Zn2+ promotes the in vitro thioflavin-T-positive aggregations of C-terminal fragments (CTFs) termed TDP-432C and TDP-432C-A315T that encompass the RRM2 and CTD domains.	Zinc	27-31	ribonucleotide reductase M2	Mus musculus	174-178
33177311-6	2021	The proliferation and ALP activity of BMSCs was significantly higher in group MAO-Ti+HA and MAO-Ti+HA+Zn(High), but MAO-Ti+HA+Zn(High) showed better antibacterial performance.	Zinc	102-104	ATHS	Homo sapiens	22-25
32581187-2	2021	Calmodulin activity is reportedly modulated also by other nutritional divalent cations; thus, we attempted to determine whether Zn++ is involved in the regulation of ABCA1 stability through the modulation of calmodulin activity.	Zinc	128-132	ATP binding cassette subfamily A member 1	Homo sapiens	166-171
32581187-3	2021	METHODS: The effects of Zn++ on ABCA1 expression was investigated in J774 mouse macrophage cell-line cells and HepG2 human hepatoma cell-line cells.	Zinc	24-28	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	32-37
32581187-4	2021	RESULTS: Zn++ increased ABCA1 expression, not by increasing the mRNA but by attenuating its decay rate, more prominently in the presence of cAMP.	Zinc	9-12	ATP binding cassette subfamily A member 1	Homo sapiens	24-29
32581187-6	2021	Calmodulin binding to ABCA1 was increased by Zn++ and Ca++.	Zinc	45-49	ATP binding cassette subfamily A member 1	Homo sapiens	22-27
32581187-7	2021	Zn++ suppressed calpain-mediated hydrolysis of the peptide of ABCA1 cytosolic loop, including the PEST sequence and the calmodulin-binding site, in a calmodulin-dependent fashion, in the presence of the minimum amount of Ca++ to activate calpain, but not calmodulin.	Zinc	0-4	ATP binding cassette subfamily A member 1	Homo sapiens	62-67
32581187-9	2021	CONCLUSION: Nutritional divalent cation Zn++ is involved in the regulation of ABCA1 activity and biogenesis of HDL through the modulation of calmodulin activity.	Zinc	40-44	ATP binding cassette subfamily A member 1	Homo sapiens	78-83
33617884-4	2021	Removal of LECT2"s single bound Zn2+ appears to be obligatory for fibril formation.	Zinc	32-35	leukocyte cell derived chemotaxin 2	Homo sapiens	11-16
33572411-3	2021	Here, we propose a two-step process that allows the formation of compact, uniform, and conformal Ni/NiP shell on Zn-based alloy microparticles without agglomeration.	Zinc	113-115	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	100-103
33515129-0	2021	Ultrasensitive electrochemical immunosensor based on the signal amplification strategy of the competitive reaction of Zn2+ and ATP ions to construct a "signal on" mode GOx-HRP enzyme cascade reaction.	Zinc	118-122	hydroxyacid oxidase 1	Homo sapiens	168-171
33515129-2	2021	In the detection process, the ZIF-90 is turned on under mild conditions by the competitive reaction of ATP with Zn2+ and imidazole-2-carboxaldehyde (2-ICA), and the electrical signal of the system is amplified by the enzyme cascade reaction of GOx and HRP.	Zinc	112-116	hydroxyacid oxidase 1	Homo sapiens	244-247
33515129-3	2021	Finally, based on the signal amplification strategy of the competitive reaction between Zn2+ and ATP to construct a "signal on" mode, electrochemical immunosensor of GOx-HRP enzyme-linked cascade reaction was prepared.	Zinc	88-92	hydroxyacid oxidase 1	Homo sapiens	166-169
33309544-6	2021	Apoptosis, cell death, mitochondrial OS, caspase -3, caspase -9, cytosolic free Zn2+, and Ca2+ concentrations were increased in the BSO group of the TRPM2 expressing mpkCCDc14 cells, although they were diminished by the treatments of GSH, PARP-1 inhibitors (PJ34 and DPQ), and TRPM2 blockers (ACA and 2-APB).	Zinc	80-84	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	149-154
33953872-9	2021	Also, a correlation between seminal Zn concentration with fresh semen gross and progressive motility, average path velocity, and beat cross frequency, Cu with SOD and Fe and semen concentration was observed.	Zinc	36-38	general transcription factor IIE subunit 1	Homo sapiens	167-169
33201834-5	2020	CONCLUSIONS: CdSe/ZnS QDs exhibited obvious nephrotoxicity by mediating oxidative damage and inflammatory response in vitro and in vivo via NRF2/Keap1 pathway.	Zinc	18-21	kelch-like ECH-associated protein 1	Mus musculus	145-150
33202628-1	2020	This study presents the doping of higher alkanes, namely, pentadecane (C15) and hexadecane (C16), with ZnS:Mn nanoparticles to create new types of in-line optical fiber sensors with unique optical properties.	Zinc	103-106	placenta associated 8	Homo sapiens	71-74
33030499-0	2020	Zn2+ ions inhibit gene transcription following stimulation of the Ca2+ channels Cav1.2 and TRPM3.	Zinc	0-4	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	80-86
33030499-7	2020	The results show that extracellular Zn2+ ions reduced the activation of AP-1 by more than 80% following stimulation of either voltage-gated Cav1.2 channels or TRPM3 channels.	Zinc	36-40	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	140-146
32964285-9	2020	We investigated whether the cytotoxicity of TRPM7 permeant metal ions Ni2+, Zn2+, Cd2+, Co2+, Mn2+, Sr2+, and Ba2+ requires TRPM7 channel activity.	Zinc	76-80	transient receptor potential cation channel subfamily M member 7	Homo sapiens	44-49
33312665-1	2020	The research focused on assessing the risk to human health resulting from the content of selected Cr, Co, Mn, Cu, Ni, Pb, As, Zn and Sr metals in tap water supplied by Upper Silesia Water Plant to the inhabitants of the Upper Silesia region (Poland).	Zinc	126-128	nuclear RNA export factor 1	Homo sapiens	146-149
33011823-10	2020	Docking study results suggest that direct H-bonding and ionic interactions between our synthetic ligands and residues, responsible for coordination of Zn2+ along with hydrophobic interactions between our ligands and IRAP active site are the most important for the ligand binding.	Zinc	151-155	interleukin 1 receptor antagonist	Mus musculus	216-220
32629202-8	2020	In contrast, under Zn stress, leaves adapted to Zn stress by increasing the expression of VDE, thus improving NPQ.	Zinc	19-21	violaxanthin de-epoxidase, chloroplastic	Nicotiana tabacum	90-93
32629202-8	2020	In contrast, under Zn stress, leaves adapted to Zn stress by increasing the expression of VDE, thus improving NPQ.	Zinc	48-50	violaxanthin de-epoxidase, chloroplastic	Nicotiana tabacum	90-93
32629202-10	2020	In comparison, only eight of the above proteins (PPD6, OEE3-2, PsbL, PsbQ, Psb27-H1, psaL, and psaOL) were significantly down-regulated by Zn stress.	Zinc	139-141	PSII reaction center subunit XII	Nicotiana tabacum	63-67
32629202-16	2020	Under Zn stress, the expressions of ndhH and PGRL1A in leaves were significantly up-regulated, but there were no significant changes in either NDH-CEF or PGR5/PGRL-CEF.	Zinc	6-8	NADH dehydrogenase 49 kDa subunit	Nicotiana tabacum	36-40
32559370-3	2020	In parallel, research into the metallobiology of AD has shown that Zn2+ can strongly modulate the aggregation of Abeta in vitro and both promote and inhibit the neurotoxicity of Abeta, depending on the experimental conditions.	Zinc	67-71	amyloid beta precursor protein	Rattus norvegicus	113-118
32559370-5	2020	However, there has been relatively little research investigating the effects of Abeta self-assembly and toxicity inhibitors in the presence of Zn2+.	Zinc	143-147	amyloid beta precursor protein	Rattus norvegicus	80-85
32126253-7	2020	However, the amounts of LC3-II and p62 and the LC3-II/LC3-I ratio were increased either by the lysosomal inhibitors and the Zn compounds.	Zinc	124-126	nucleoporin 62	Mus musculus	35-38
32126253-7	2020	However, the amounts of LC3-II and p62 and the LC3-II/LC3-I ratio were increased either by the lysosomal inhibitors and the Zn compounds.	Zinc	124-126	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	24-27
31893608-9	2020	This revealed that compound 4 coordinated with the Zn2+ ion in the hCAII active site through its methoxy oxygen at a distance of 1.60 A (FlexX) or 2.29 A (Swissdock).	Zinc	51-55	carbonic anhydrase 2	Homo sapiens	67-72
32006912-6	2020	The sensing behavior of MPS-capped ZnS QDs for selective and sensitive detection of vitamin A, vitamin B2, vitamin B6, vitamin E, vitamin K, vitamin H, vitamin D3 and vitamin C was investigated using fluorescence spectroscopy.	Zinc	35-38	immunoglobulin kappa variable 5-2	Homo sapiens	103-117
32067010-5	2020	When discharged at 1 mA cm-2, the hybrid Zn battery shows two discharge plateaus at 1.75 V and 1.11 V. Its specific capacity and energy density reach 711 mA h g-1 and 810 W h kg-1, respectively.	Zinc	41-43	proline rich protein BstNI subfamily 3	Homo sapiens	159-179
31172426-10	2020	The MMP-2 and MMP-13 analyses showed that the expression of the high-Zn group was significantly higher than that of the normal group, indicating that Zn plays an important role in its expression.	Zinc	150-152	matrix metallopeptidase 2	Mus musculus	4-9
31884326-3	2020	However, the role of the primary nitrate transporter NRT1.1 in Zn accumulation in plants remains unknown.	Zinc	63-65	nitrate transporter 1.1	Arabidopsis thaliana	53-59
31884326-4	2020	In this study, a Zn stress-induced increase in nitrate uptake and an increase in NRT1.1 protein levels in wild-type (Col-0) Arabidopsis plants were measured using microelectrode ion flux and green fluorescent protein (GFP)/beta-glucuronidase (GUS) staining, respectively.	Zinc	17-19	nitrate transporter 1.1	Arabidopsis thaliana	81-87
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	142-144	nitrate transporter 1.1	Arabidopsis thaliana	66-72
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	142-144	nitrate transporter 1.1	Arabidopsis thaliana	85-91
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	142-144	nitrate transporter 1.1	Arabidopsis thaliana	96-102
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	179-181	nitrate transporter 1.1	Arabidopsis thaliana	66-72
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	179-181	nitrate transporter 1.1	Arabidopsis thaliana	85-91
31884326-5	2020	Both agar and hydroponic cultures showed that mutants lacking the NRT1.1 function in nrt1.1 and chl1-5 (chlorate resistant 1) exhibited lower Zn levels in the roots and shoots of Zn-stressed plants than the wild-type.	Zinc	179-181	nitrate transporter 1.1	Arabidopsis thaliana	96-102
31884326-6	2020	A lack of NRT1.1 activity also alleviated Zn-induced photosynthetic damage and growth inhibition in plants.	Zinc	42-44	nitrate transporter 1.1	Arabidopsis thaliana	10-16
31884326-9	2020	From these results, it can be concluded that NRT1.1 modulates Zn accumulation in plants via a nitrate-dependent pathway.	Zinc	62-64	nitrate transporter 1.1	Arabidopsis thaliana	45-51
31986280-0	2020	CuO-ZnO heterojunction derived from Cu2+-doped ZIF-8: A new photoelectric material for ultrasensitive PEC immunoassay of CA125 with near-zero background noise.	Zinc	0-7	mucin 16, cell surface associated	Homo sapiens	121-126
31986280-3	2020	Under visible light irradiation, CuO-ZnO heterojunction exhibits excellent PEC behavior in aqueous media with the presence of ascorbic acid (AA) and dissolved oxygen at -0.3 V. Taking the CA125-antibody functionalized CuO-ZnO heterojunction (CuO-ZnO-Ab2) as a signal source, a novel photoelectrochemical (PEC) immunosensing platform was developed for ultrasensitive assay of CA125.	Zinc	33-40	mucin 16, cell surface associated	Homo sapiens	188-193
31986280-3	2020	Under visible light irradiation, CuO-ZnO heterojunction exhibits excellent PEC behavior in aqueous media with the presence of ascorbic acid (AA) and dissolved oxygen at -0.3 V. Taking the CA125-antibody functionalized CuO-ZnO heterojunction (CuO-ZnO-Ab2) as a signal source, a novel photoelectrochemical (PEC) immunosensing platform was developed for ultrasensitive assay of CA125.	Zinc	33-40	mucin 16, cell surface associated	Homo sapiens	375-380
31986280-3	2020	Under visible light irradiation, CuO-ZnO heterojunction exhibits excellent PEC behavior in aqueous media with the presence of ascorbic acid (AA) and dissolved oxygen at -0.3 V. Taking the CA125-antibody functionalized CuO-ZnO heterojunction (CuO-ZnO-Ab2) as a signal source, a novel photoelectrochemical (PEC) immunosensing platform was developed for ultrasensitive assay of CA125.	Zinc	218-225	mucin 16, cell surface associated	Homo sapiens	188-193
31986280-3	2020	Under visible light irradiation, CuO-ZnO heterojunction exhibits excellent PEC behavior in aqueous media with the presence of ascorbic acid (AA) and dissolved oxygen at -0.3 V. Taking the CA125-antibody functionalized CuO-ZnO heterojunction (CuO-ZnO-Ab2) as a signal source, a novel photoelectrochemical (PEC) immunosensing platform was developed for ultrasensitive assay of CA125.	Zinc	242-253	mucin 16, cell surface associated	Homo sapiens	188-193
32065320-6	2020	The results showed that ALD-fabricated Au-ZnO heterostructures exhibited one of the highest sensitivities of 0.53 muA muM-1 cm-2, the widest linear H2O2 detection range of 1.0 muM-120 mM, a low limit of detection (LOD) of 0.78 muM, excellent selectivity under the normal operation conditions, and great long-term stability.	Zinc	42-45	PWWP domain containing 3A, DNA repair factor	Homo sapiens	118-128
32075143-0	2020	Spin-Glass Transitions in Zn1-xFexO Nanoparticles.	Zinc	26-35	spindlin 1	Homo sapiens	0-4
32075143-7	2020	There are a superexchange interaction and an indirect exchange interaction that is provided by the spin (and charge) itinerant carriers in a spin-polarized band situated in the vicinity of the Fermi level of the Fe-doped ZnO semiconductor.	Zinc	221-224	spindlin 1	Homo sapiens	99-103
31761550-4	2020	We further discovered that surface charge of ZnO NPs were modified after Cd2+ adsorption and the resulting nanoadducts caused more severe damages in placental barriers by causing shed endothelial cells and decreased expressions of tight junction proteins ZO1, occludin, claudin-4 and claudin-8.	Zinc	45-48	claudin 8	Homo sapiens	284-293
31935838-2	2020	The aim of the study was to determine the influence of Zn and/or Se supplementation on the androgen receptor (AR) in the prostate lobes and the serum selected hormone concentrations; a hitherto unresearched topic.	Zinc	55-57	androgen receptor	Rattus norvegicus	91-108
31935838-2	2020	The aim of the study was to determine the influence of Zn and/or Se supplementation on the androgen receptor (AR) in the prostate lobes and the serum selected hormone concentrations; a hitherto unresearched topic.	Zinc	55-57	androgen receptor	Rattus norvegicus	110-112
31935838-8	2020	CONCLUSION: This paper presents the first report of the influence of Zn and/or Se supplementation on the protein expression of AR in the prostate.	Zinc	69-71	androgen receptor	Rattus norvegicus	127-129
31842499-6	2019	On the other hand, mRNA of FGF1, TGF1, TCIRG1, and adenosine deaminase (ADA) were higher expressed (p &lt; 0.05) in the spleen tissues of Cu/Zn-Mnt group.	Zinc	141-143	adenosine deaminase	Oryctolagus cuniculus	51-70
31824152-10	2019	In addition, PEG-InP/ZnS QDs triggered oxidative stress and the ER stress-related PERK-ATF4 pathway in the BMMs.	Zinc	21-24	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	82-86
31799425-4	2019	Previously, we showed that the BTB/POZ-Zn-finger protein Mamo is necessary for vasa expression in Drosophila.	Zinc	35-41	maternal gene required for meiosis	Drosophila melanogaster	57-61
31675222-5	2019	(2)Zn2Cl4 undergoes macrocyclic ring inversion on the nuclear magnetic resonance (NMR) time scale with a free energy barrier DeltaG  of 15.5(3) kcal/mol at 295 K. In contrast, (2)Fe2Cl4 and (2)Co2Cl4 undergo slow ring inversion on the NMR chemical shift time scale at 295 K. The amine elimination reaction of 2" with Zr(NMe2)4 yields the bis-PDE complex (2"-4H)Zr2(NMe2)4, which was alkylated with AlMe3 and Al(CH2SiMe3)3 to generate (2"-4H)Zr2Me4 and (2"-4H)Zr2(CH2SiMe3)2(NMe2)2, respectively.	Zinc	3-9	aldehyde dehydrogenase 7 family member A1	Homo sapiens	342-345
31493760-4	2019	The adsorption efficiency of MOS/OCN-1 was &gt;94% even under high concentration of coexisting ions (i.e., Ca2+, Mg2+ and Zn2+).	Zinc	122-126	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	29-32
31690045-8	2019	The presence of BCT was associated with a reduction to Glu117 usage in all variants, suggesting implications for Zn 2 + dissociation from the CA-II active site.	Zinc	113-115	carbonic anhydrase 2	Homo sapiens	142-147
31532427-6	2019	Understanding the interplay between Fe(ii) and Zn(ii) binding to Isu1 in vitro may help clarify metal loading events that occur during Fe-S cluster assembly in vivo.	Zinc	47-53	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	65-69
31532427-7	2019	Here we determine the metal : protein stoichiometry for Isu1 Zn and Fe binding to be 1 : 1 and 2 : 1, respectively.	Zinc	61-63	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	56-60
31532427-8	2019	As expected, while Zn binding shifts the Isu1 to its structured state, folding is not influenced by Fe(ii) binding.	Zinc	19-21	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	41-45
31532427-10	2019	XAS results show Isu1 binding initially of either Fe(ii) or Zn(ii) does not significantly perturb the metal site structure of alternate metal.	Zinc	60-66	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	17-21
31532427-13	2019	Finally, in our report Zn binding dramatically reduces the Fe-S cluster assembly activity of Isu1 even in the presence of frataxin.	Zinc	23-25	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	93-97
31857947-12	2019	The concentrations of Fe, Co, Ni, Cu, Zn and Br were significantly higher in the KRAS mutation and wild-type groups than in the control group regardless of whether the samples were from tumor or peritumor tissues.	Zinc	38-40	KRAS proto-oncogene, GTPase	Homo sapiens	81-85
31364019-11	2019	In conclusion, increasing levels of Se and Zn decreases the intensity of inflammation as measured by IL-6, IL-10 and TNF-alpha levels.	Zinc	43-45	interleukin 10	Homo sapiens	107-112
31384878-7	2019	In the whole study population after the completion of the intervention hair Zn correlated positively with serum HEPC and FAM and negatively with serum FE.	Zinc	76-78	general transcription factor IIE subunit 1	Homo sapiens	151-153
30613975-0	2019	beta3 -adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn2+ and reactive nitrogen species.	Zinc	146-150	adrenoceptor beta 3	Rattus norvegicus	0-26
31152065-11	2019	A cyanamide soak of the Ddi2-T157V enzyme revealed cyanamide bound directly to the Zn2+ ion, having displaced the zinc-bound water molecule.	Zinc	83-87	cyanamide hydratase	Saccharomyces cerevisiae S288C	24-28
30952027-3	2019	Further, the high selectivity of receptor 1 towards Hg2+ ions in the presence of various other interfering metal ions like Ni2+, Zn2+, Mn2+, Co2+, Cu2+, Cr3+, Fe3+, Al3+, Ag+, Fe2+, Cd2+, Mg2+, Pb2+, Ca2+, Na+, K+ was confirmed by UV-Vis and fluorescence methods.	Zinc	129-133	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	52-55
31150090-0	2019	Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death.	Zinc	25-29	carbonic anhydrase 1	Homo sapiens	46-49
31150090-1	2019	Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent neurodegeneration.	Zinc	14-18	carbonic anhydrase 1	Homo sapiens	49-52
31150090-7	2019	These data provide the first direct characterization of Zn2+ accumulation in CA1 mitochondria after in vivo TGI, and support the idea that targeting these events could yield therapeutic benefits.	Zinc	56-60	carbonic anhydrase 1	Homo sapiens	77-80
30903842-7	2019	Therefore, NOM affects the release of Zn2+ and Ag+ from NOM-treated nAg and nZnO but does not promote the aggregation of NOM-treated nAg and nZnO, which influences the inhalation risk-based assessment.	Zinc	38-42	NBAS subunit of NRZ tethering complex	Homo sapiens	68-71
31333278-1	2019	The reactions of 1-methyl-1,3-dihydro-2H-benzimidazole-2-selone, H(sebenzimMe), towards the zinc and cadmium halides, MX2 (M = Zn, Cd; X = Cl, Br, I), afford the adducts, [H(sebenzimMe)]2MX2, which have been structurally characterized by X-ray diffraction.	Zinc	127-129	MX dynamin like GTPase 2	Homo sapiens	118-121
30831423-8	2019	Additionally, MPG/HAC conditioning might be appropriate for stabilization of Cd, Cr and Zn in water supply sludge, especially for Zn.	Zinc	88-90	N-methylpurine DNA glycosylase	Homo sapiens	14-17
30831423-8	2019	Additionally, MPG/HAC conditioning might be appropriate for stabilization of Cd, Cr and Zn in water supply sludge, especially for Zn.	Zinc	130-132	N-methylpurine DNA glycosylase	Homo sapiens	14-17
30827506-2	2019	The activity of Cav3.2 is enhanced by H2S, a gasotransmitter, and suppressed by ascorbic acid (vitamin C) through metal-catalyzed oxidation of the Zn2+-binding His191 in Cav3.2.	Zinc	147-151	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	16-22
30827506-2	2019	The activity of Cav3.2 is enhanced by H2S, a gasotransmitter, and suppressed by ascorbic acid (vitamin C) through metal-catalyzed oxidation of the Zn2+-binding His191 in Cav3.2.	Zinc	147-151	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	170-176
30803063-4	2019	Furthermore, wearable Zn-air battery based on Co SA@NCF/CNF air electrode displays superior stability under deformation, satisfactory energy storage capacity, and good practicality to be utilized as an integrated battery system.	Zinc	22-24	NPHS1 adhesion molecule, nephrin	Homo sapiens	56-59
30762184-1	2019	Stearyl trimethyl ammonium chloride (STAC) and ethylenediamine (En) were successfully implanted into montmorillonite (MMt) interlayer to fabricate the novel adsorbent STAC-En-MMt for the simultaneous adsorption of Cu2+, Zn2+, and p-nitrophenol (PNP).	Zinc	220-224	SH3 and cysteine rich domain	Homo sapiens	37-41
30762184-1	2019	Stearyl trimethyl ammonium chloride (STAC) and ethylenediamine (En) were successfully implanted into montmorillonite (MMt) interlayer to fabricate the novel adsorbent STAC-En-MMt for the simultaneous adsorption of Cu2+, Zn2+, and p-nitrophenol (PNP).	Zinc	220-224	SH3 and cysteine rich domain	Homo sapiens	167-171
30675888-1	2019	Zinc (Zn) is distributed throughout the body and within cells by saturable processes mediated by the transport proteins of the ZnT (SLC30) and ZIP (SLC39) families.	Zinc	6-8	death associated protein kinase 3	Homo sapiens	143-146
30893306-10	2019	Finally, based on computational energy calculations, we propose that ZnT2 functions as an antiporter with a stoichiometry of 2H+/Zn2+ ion.	Zinc	129-133	solute carrier family 30 member 2	Homo sapiens	69-73
30853849-2	2019	Here, we analyzed the binding thermodynamics and characterized the structural effect of divalent metal ions, i.e. Mn2+, Zn2+, and Mg2+, to the isolated ribonuclease H (RNH) of human immunodeficiency virus (HIV) using isothermal titration calorimetry (ITC) and circular dichroism.	Zinc	120-124	ribonuclease/angiogenin inhibitor 1	Homo sapiens	168-171
30853849-3	2019	The binding thermodynamics of Mg2+ to RNH was determined using competition ITC experiments, and the binding affinity of Mg2+ was found to be about 40- and 400-times lower than those of Mn2+ and of Zn2+, respectively.	Zinc	197-201	ribonuclease/angiogenin inhibitor 1	Homo sapiens	38-41
29716435-7	2019	Elevated AnxA5 signal upon Zn2+ treatment was confirmed in murine placentae.	Zinc	27-31	annexin A5	Mus musculus	9-14
29716435-8	2019	Micromolar Zn2+ stimulated ANXA5 expression in cell culture directly and alleviated RPL in AnxA5 genetically deficient mice, without notable toxicity effects.	Zinc	11-15	annexin A5	Mus musculus	27-32
29716435-8	2019	Micromolar Zn2+ stimulated ANXA5 expression in cell culture directly and alleviated RPL in AnxA5 genetically deficient mice, without notable toxicity effects.	Zinc	11-15	annexin A5	Mus musculus	91-96
30608112-6	2019	The high stiffness of the BANF network combined with the high ionic conductivity of soft poly(ethylene oxide) enable effective suppression of dendrites and fast Zn2+ transport.	Zinc	161-165	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	26-30
30476185-5	2019	We show that DNA binding by Haa1 is induced in the presence of acetic acid and that the N-terminal Zn-binding domain is essential for this activity.	Zinc	99-101	Haa1p	Saccharomyces cerevisiae S288C	28-32
30340207-2	2019	The macrocycle serves as a highly selective colorimetric sensor for Hg2+ ions while it acts as an excellent fluorescent sensor for Zn2+ ions by exhibiting a green fluorescence at 498 nm even in the presence of interfering ions.	Zinc	131-135	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	68-71
30723194-2	2019	Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone ERp44, modulating its localization and ability to retrieve clients like Ero1alpha and ERAP1 to the endoplasmic reticulum (ER).	Zinc	19-23	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	151-160
30723194-3	2019	Silencing the Zn2+ transporters that uptake Zn2+ into the Golgi led to ERp44 dysfunction and increased secretion of Ero1alpha and ERAP1.	Zinc	14-18	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	116-125
30520657-3	2019	As for other ions and solutes, Zn2+ is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins.	Zinc	31-35	Malvolio	Drosophila melanogaster	116-121
30422662-6	2019	Zn2+ rapidly stimulated the activity of the multidrug resistance-related protein 2 (Mrp2), p-glycoprotein (P-gp), and breast cancer resistance protein (Bcrp).	Zinc	0-4	ATP binding cassette subfamily C member 2	Rattus norvegicus	44-82
30422662-6	2019	Zn2+ rapidly stimulated the activity of the multidrug resistance-related protein 2 (Mrp2), p-glycoprotein (P-gp), and breast cancer resistance protein (Bcrp).	Zinc	0-4	ATP binding cassette subfamily C member 2	Rattus norvegicus	84-88
30422662-6	2019	Zn2+ rapidly stimulated the activity of the multidrug resistance-related protein 2 (Mrp2), p-glycoprotein (P-gp), and breast cancer resistance protein (Bcrp).	Zinc	0-4	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	91-105
30422662-6	2019	Zn2+ rapidly stimulated the activity of the multidrug resistance-related protein 2 (Mrp2), p-glycoprotein (P-gp), and breast cancer resistance protein (Bcrp).	Zinc	0-4	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	107-111
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	ATP binding cassette subfamily C member 2	Rattus norvegicus	19-23
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	28-32
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	protein kinase C, alpha	Rattus norvegicus	158-161
30422662-8	2019	Studies focused on Mrp2 and P-gp showed that Zn2+ induced signaling through an endothelin receptor type B (ETB)/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway and caused, specifically, an activation of the isoform PKCalpha.	Zinc	45-49	protein kinase C, alpha	Rattus norvegicus	226-234
30422662-11	2019	An initial in vivo study in rats suggested enhanced P-gp transport activity at the BBB due to elevated Zn2+ plasma levels.	Zinc	103-107	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	52-56
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Zinc	179-181	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	17-57
30873821-1	2019	BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn).	Zinc	179-181	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	59-64
30873821-9	2019	When compared to C57Bl6/J and B6129SF2/J, TRPC6-/- mice had elevated Zn levels in placenta, liver and kidney during embryonic development and postnatally, but not at adulthood.	Zinc	69-71	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	42-47
30873821-12	2019	CONCLUSION: This work indicates that TRPC6 exerts critical pathophysiological functions in placenta, and provides further evidence for a role of this channel in the homeostasis of cations like Zn and Fe.	Zinc	193-195	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	37-42
30257870-0	2018	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	Zinc	52-56	ubiquitin protein ligase E3A	Homo sapiens	93-98
30257870-4	2018	We map the interaction to the highly conserved Zn2+-binding N-terminal (AZUL) domain of UBE3A, the integrity of which is crucial for binding to PSMD4.	Zinc	47-51	ubiquitin protein ligase E3A	Homo sapiens	88-93
30295474-11	2018	X-ray absorption and infrared  spectroscopies revealed that Zn(CN2)-like intermediate species were generated at the middle temperature range and Ga-N bonds formed at high temperature along with dissociation of CO and CO2.	Zinc	60-62	carnosine dipeptidase 2	Homo sapiens	63-66
30221929-3	2018	Here, the conformational preferences from partial metalation of rabbit metallothionein-2A (MT) by Cd2+, Zn2+, and Ag+ are studied using nanoelectrospray ionization ion mobility mass spectrometry.	Zinc	104-108	metallothionein-2A	Oryctolagus cuniculus	71-89
30356695-10	2018	We found that capzimin interacts with the active site Zn+2 of Rpn11 in a bidentate manner and also interacts with the residues in the distal ubiquitin binding site.	Zinc	54-56	proteasome 26S subunit, non-ATPase 14	Homo sapiens	62-67
30007635-4	2018	Decreasing pectin DM or increasing DBabs promoted Zn2+ binding, with the estimated binding capacity (mol Zn2+/mol GalA) and binding constant (mM-1) being mainly determined by pectin DBabs, rather than DM.	Zinc	50-54	galactosidase alpha	Homo sapiens	114-118
30173384-1	2018	Mammalian delta-aminolevulinate dehydratase (delta-ALA-D) is a metalloenzyme, which requires Zn(II) and reduced thiol groups for catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Zinc	93-99	aminolevulinate dehydratase	Homo sapiens	10-43
30173384-1	2018	Mammalian delta-aminolevulinate dehydratase (delta-ALA-D) is a metalloenzyme, which requires Zn(II) and reduced thiol groups for catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Zinc	93-99	aminolevulinate dehydratase	Homo sapiens	45-56
30173384-9	2018	The results indicate that a possible mechanism of inhibition of delta-ALA-D by these metals may involve the replacement of the Zn(II) from the active site and/or the cysteinyl residue oxidation.	Zinc	127-133	aminolevulinate dehydratase	Homo sapiens	64-75
30150315-9	2018	We show that ZIP4 and ZIP9 respond to the local Zn status in both roots and shoots, in contrast to the systemic regulation identified here.	Zinc	48-50	solute carrier family 39 member 4	Homo sapiens	13-17
30260988-4	2018	Our X-ray structural analysis of C1orf123 further revealed that it binds a Zn2+ ion in a tetrahedral coordination with four thiolate groups from two conserved CxxC motifs.	Zinc	75-79	CXXC motif containing zinc binding protein	Homo sapiens	33-41
29893856-3	2018	ZBTB11 encodes a little-studied transcription regulator, and the two identified missense variants in this study are predicted to disrupt canonical Zn2+-binding residues of its C2H2 zinc finger domain, leading to possible altered DNA binding.	Zinc	147-151	zinc finger and BTB domain containing 11	Homo sapiens	0-6
29893856-8	2018	In conclusion, we report two ID families segregating ZBTB11 biallelic mutations disrupting Zn2+-binding motifs and provide functional evidence linking ZBTB11 dysfunction to this phenotype.	Zinc	91-95	zinc finger and BTB domain containing 11	Homo sapiens	53-59
30213975-3	2018	Zn2+, Mn2+ and Fe2+ transform TTR into a protease able to cleave Abeta.	Zinc	0-4	transthyretin	Homo sapiens	30-33
30138481-9	2018	The ASR1-DNA binding is sequence specific and dependent on Zn2+.	Zinc	59-63	abscisic stress-ripening protein 1	Solanum lycopersicum	4-8
30272000-3	2018	Here we report the crystallographic structures of human Dcytb and its complex with ascorbate and Zn2+.	Zinc	97-101	cytochrome b reductase 1	Homo sapiens	56-61
29851018-7	2018	When 12.5 g/L of MA-2 was applied to treat smelting wastewater, over 99% removal of Cu2+, Zn2+, Pb2+, and Cd2+ was achieved.	Zinc	90-94	PNMA family member 2	Homo sapiens	17-21
29684495-7	2018	The ranking order of metals concentrations in the tap drinking water was Zn &gt; Pb &gt; As &gt; Co &gt; Hg.	Zinc	73-75	nuclear RNA export factor 1	Homo sapiens	50-53
29872214-6	2018	Zn2+-bound fragments of both N-terminal and C-terminal ends of the peptide were identified from collision-induced dissociation (CID) and electron transfer dissociation/proton transfer reaction (ETD/PTR) experiments, suggesting that multiple binding sites exist within this region of HRG.	Zinc	0-4	histidine rich glycoprotein	Homo sapiens	283-286
29058176-3	2018	The activation/phosphorylation of some proteins including Zn2+-transporter ZIP7 in cardiomyocytes is controlled with CK2alpha, thereby, inducing changes in the level of intracellular free Zn2+ ([Zn2+] i ).	Zinc	188-192	casein kinase 2 alpha 2	Homo sapiens	117-125
29058176-9	2018	Therefore, our present data demonstrated, for the first time, the physiological relevance of CK2alpha in cellular control of Zn2+-distribution via inducing ZIP7 phosphorylation and activation of these above endogenous actors in hyperglycemia/diabetes-associated cardiac dysfunction.	Zinc	125-129	casein kinase 2 alpha 2	Homo sapiens	93-101
29659256-6	2018	Initial metal-depletion studies demonstrate that mCP depletes multiple first-row transition metal ions, including Mn, Fe, Ni, Cu, and Zn, from complex microbial growth medium, indicating that mCP binds multiple nutrient metals with high affinity.	Zinc	134-136	CD46 antigen, complement regulatory protein	Mus musculus	49-52
29659256-6	2018	Initial metal-depletion studies demonstrate that mCP depletes multiple first-row transition metal ions, including Mn, Fe, Ni, Cu, and Zn, from complex microbial growth medium, indicating that mCP binds multiple nutrient metals with high affinity.	Zinc	134-136	CD46 antigen, complement regulatory protein	Mus musculus	192-195
29468392-3	2018	High level of Zn led to reduce dry mass, chlorophyll pigments, fruit yield, leaf maximum fluorescence, and relative water content, but enhanced endogenous hydrogen peroxide (H2O2), free proline, malondialdehyde (MDA), electrolyte leakage (EL), H2S, as well as the activities of peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) enzymes.	Zinc	14-16	catalase	Capsicum annuum	296-304
29468392-3	2018	High level of Zn led to reduce dry mass, chlorophyll pigments, fruit yield, leaf maximum fluorescence, and relative water content, but enhanced endogenous hydrogen peroxide (H2O2), free proline, malondialdehyde (MDA), electrolyte leakage (EL), H2S, as well as the activities of peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) enzymes.	Zinc	14-16	catalase	Capsicum annuum	306-309
29548726-7	2018	A decrease in the expression of the gene encoding the neuro-trophic factor (BDNF) associated with overexpression of the encoding the metal regulatory transcription factor 1 (MTF1), factor involved in the homeostasis of Zn, was also noted in Cd group.	Zinc	219-221	brain-derived neurotrophic factor	Rattus norvegicus	76-80
29519735-0	2018	Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).	Zinc	86-88	euchromatic histone lysine methyltransferase 2	Homo sapiens	48-51
29316128-3	2018	Here, we demonstrate the ranking power of the semiempirical quantum mechanics (SQM)/implicit solvent (COSMO) scoring function by using a challenging set of 10 inhibitors binding to carbonic anhydrase II through Zn2+ in the active site.	Zinc	211-215	carbonic anhydrase 2	Homo sapiens	181-202
29351417-9	2018	Zn2+ also regulated inflammation-related key molecules such as heme oxygenase-1, selectin L, IL-10, and platelet endothelial cell adhesion molecule 1, as well as vascular tone-related prostaglandin I2 synthase and nitric oxide synthase-3.	Zinc	0-4	interleukin 10	Homo sapiens	93-98
29129644-2	2018	Emerging evidence indicate that one of the main physiological functions of TRPM6 and TRPM7 is maintaining of cellular metabolism of Mg2+ and likely other essential metals such as Ca2+ and Zn2+.	Zinc	188-192	transient receptor potential cation channel subfamily M member 6	Homo sapiens	75-80
29129644-2	2018	Emerging evidence indicate that one of the main physiological functions of TRPM6 and TRPM7 is maintaining of cellular metabolism of Mg2+ and likely other essential metals such as Ca2+ and Zn2+.	Zinc	188-192	transient receptor potential cation channel subfamily M member 7	Homo sapiens	85-90
29381858-2	2018	Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin).	Zinc	0-6	S100 calcium binding protein A9	Homo sapiens	118-124
29210127-3	2018	Herein, we report on a novel exchange reaction, in which metal halides MX2 (M=Zn, Mg, Cu, or Ca; X=Cl, Br, or I) solids act as anion source to directly prepare CsPbX3 NCs at room temperature without any pretreatment.	Zinc	78-80	MX dynamin like GTPase 2	Homo sapiens	71-74
29403274-0	2018	Magnetic immunoassay using CdSe/ZnS quantum dots as fluorescent probes to detect the level of DNA methyltransferase 1 in human serum sample.	Zinc	32-35	DNA methyltransferase 1	Homo sapiens	94-117
29122608-6	2018	In this study, we examined the effect of HSA-Trx on Cu2+/Zn2+-induced neurotoxicity.	Zinc	57-61	thioredoxin 1	Mus musculus	45-48
29122608-7	2018	Firstly, HSA-Trx was found to clearly suppress Cu2+/Zn2+-induced neuronal cell death in mouse hypothalamic neuronal cells (GT1-7 cells).	Zinc	52-56	thioredoxin 1	Mus musculus	13-16
29122608-8	2018	Moreover, HSA-Trx markedly suppressed Cu2+/Zn2+-induced ROS production and the expression of oxidative stress related genes, such as heme oxygenase-1.	Zinc	43-47	thioredoxin 1	Mus musculus	14-17
29122608-10	2018	Finally, HSA-Trx was found to significantly suppress endoplasmic reticulum (ER) stress response induced by Cu2+/Zn2+ treatment in a dose dependent manner.	Zinc	112-116	thioredoxin 1	Mus musculus	13-16
29122608-11	2018	These results suggest that HSA-Trx counteracted Cu2+/Zn2+-induced neurotoxicity by suppressing the production of ROS via interfering the related gene expressions, in addition to the highly possible radical scavenging activity of the fusion protein.	Zinc	53-57	thioredoxin 1	Mus musculus	31-34
29181969-4	2017	We observe that one DNA (MB2) will open its hairpin structure upon partial hybridization with target miR-21 after entering into cells, and the other part of its hairpin structure could further react with the other hairpin DNA (MB1) to form a Zn2+-specific DNAzyme.	Zinc	242-246	proteasome 20S subunit beta 5	Homo sapiens	227-230
29326590-15	2017	Finally, a P2X4/2R chimera did not respond to IVM but Zn(II) elicited a 2.7 +- 0.6-fold increase in the ATP-gated current.	Zinc	54-60	purinergic receptor P2X 4	Rattus norvegicus	11-15
29311807-6	2017	Single cell imaging demonstrated that H2O2 evoked a prominent increase in the intracellular Zn2+ concentration, which was completely prevented by TPEN as well as TRPM2-KO and inhibition of the TRPM2 channel.	Zinc	92-96	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	162-167
29311807-6	2017	Single cell imaging demonstrated that H2O2 evoked a prominent increase in the intracellular Zn2+ concentration, which was completely prevented by TPEN as well as TRPM2-KO and inhibition of the TRPM2 channel.	Zinc	92-96	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	193-198
29311807-9	2017	Taken together, our results provide evidence to show that a dynamic alteration in the intracellular Zn2+ homeostasis as a result of activation of the TRPM2 channel contributes to ROS-induced hippocampal neuronal death.	Zinc	100-104	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	150-155
29215553-5	2017	Both Zn complexes elicited potent blood glucose-lowering effects and improved HbA1c values.	Zinc	5-7	hemoglobin alpha, adult chain 1	Mus musculus	78-82
28892299-2	2017	Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating microRNA (miRNA, miR) expression.	Zinc	6-8	membrane associated ring-CH-type finger 8	Homo sapiens	131-134
28948272-0	2017	Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-beta4-16 peptide and Zn7-metallothionein-3.	Zinc	40-42	metallothionein 3	Homo sapiens	96-113
29066724-3	2017	A previous NMR structure of DCD-1L in 50% TFE showed a partial helical conformation, and its crystal structure in the presence of Zn2+ outlined a hexameric linear alpha-helical bundle.	Zinc	130-134	dermcidin	Homo sapiens	28-31
28888679-1	2017	Coupling of asymmetric flow field-flow fractionation (AF4) to an on-line elemental detection (inductively coupled plasma-mass spectrometry, ICP-MS) has been recently proposed as a powerful diagnostic tool for characterization of the bioconjugation of CdSe/ZnS core-shell Quantum Dots (QDs) to antibodies.	Zinc	256-259	AF4/FMR2 family member 1	Homo sapiens	54-57
28875161-3	2017	We report two crystal structures of a prokaryotic ZIP in lipidic cubic phase with bound metal substrates (Cd2+ at 2.7 A and Zn2+ at 2.4 A).	Zinc	124-128	death associated protein kinase 3	Homo sapiens	50-53
28787130-10	2017	TRPM7 and GPR39 appear to be the major cellular receptors facilitating Zn2+-entry into hMSC.	Zinc	71-75	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-5
31457757-0	2017	Modeling the Active Site of the Purple Acid Phosphatase Enzyme with Hetero-Dinuclear Mixed Valence M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] Complexes Supported over a [N6O] Unsymmetrical Ligand.	Zinc	118-120	acid phosphatase 5, tartrate resistant	Homo sapiens	32-55
31457757-1	2017	The active site of the purple acid phosphatase enzyme has been successfully modeled by a series of hetero-dinuclear M(II)-Fe(III) [M = Zn, Ni, Co, and Cu] type complexes of an unsymmetrical [N6O] ligand that contained a bridging phenoxide moiety and one imidazoyl and three pyridyl moieties as the terminal N-binding sites.	Zinc	135-137	acid phosphatase 5, tartrate resistant	Homo sapiens	23-46
28685331-14	2017	However, an adverse impact of some sand-contained pollutants that are attributed to the motor traffic (Cu, Zn, Ni, Cr, Co and Pb) and low emissions (mainly As and Cd) has been established in the spa resorts in question.	Zinc	107-109	surfactant protein A2	Homo sapiens	195-198
28765513-0	2017	High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission.	Zinc	92-96	transient receptor potential cation channel subfamily M member 2	Homo sapiens	35-40
28765513-5	2017	Ca2+ that entered through TRPM2 induced lysosomal membrane permeabilization, which led to the release of lysosomal Zn2+ and a subsequent increase in mitochondrial Zn2+ Zn2+ promoted the recruitment of the fission factor Drp-1 to mitochondria to trigger their fission.	Zinc	115-119	transient receptor potential cation channel subfamily M member 2	Homo sapiens	26-31
28706347-2	2017	By exposing InZnP QDs with varying Zn/In ratios to gallium oleate and monitoring their optical properties, composition, and size, we conclude that Ga3+ preferentially replaces Zn2+, leading to the formation of InZnP/InGaP core/graded-shell QDs.	Zinc	14-16	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	147-150
28706347-2	2017	By exposing InZnP QDs with varying Zn/In ratios to gallium oleate and monitoring their optical properties, composition, and size, we conclude that Ga3+ preferentially replaces Zn2+, leading to the formation of InZnP/InGaP core/graded-shell QDs.	Zinc	176-180	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	147-150
29745158-3	2017	Compared to elevation of the level of only Cd2+ or Zn2+, the seed germination rate under elevation of both Cd2+ and Zn2+ levels was enhanced significantly; O2-  generation rate, contents of H2O2 and MDA decreased; CAT, APX and MDAR activities increased in the last stage of Cd2+ and Zn2+ exposure.	Zinc	116-120	monodehydroascorbate reductase	Nicotiana tabacum	227-231
29137232-7	2017	Searching our published microRNA profile, we find that the tumor-suppressor miR-143, a negative regulator of HK2, is down-regulated in Zn-deficient esophagus.	Zinc	135-137	hexokinase 2	Rattus norvegicus	109-112
28483976-3	2017	This apoptosis-enabling mechanism is initiated via Zn2+-dependent dual phosphorylation of Kv2.1, increasing the interaction between the channel"s intracellular C-terminus domain and the SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor) protein syntaxin 1A.	Zinc	51-55	potassium voltage-gated channel subfamily B member 1	Homo sapiens	90-95
28424257-1	2017	Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8.9 mg Fe, 2.7 mg Zn, 1050 mug retinoic acid equivalent vitamin A, and 5.5 mug vitamin B-12) or a control snack (mean: 150 kcal, 2.0 mg Fe, 0.9 mg Zn, 0 mug retinoic acid equivalent vitamin A, and 0 mug vitamin B-12) 5 d/wk for 6 mo.	Zinc	615-617	arylsulfatase F	Homo sapiens	221-224
28424257-1	2017	Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8.9 mg Fe, 2.7 mg Zn, 1050 mug retinoic acid equivalent vitamin A, and 5.5 mug vitamin B-12) or a control snack (mean: 150 kcal, 2.0 mg Fe, 0.9 mg Zn, 0 mug retinoic acid equivalent vitamin A, and 0 mug vitamin B-12) 5 d/wk for 6 mo.	Zinc	744-746	arylsulfatase F	Homo sapiens	221-224
28538697-5	2017	Owing to its anti-oxidant properties and modulator function not only for Zn, but also for Cu in the extra- and intracellular space, MT-3, but not MT-1/MT-2, protects neuronal cells from the toxicity of various Cu(II)-bound amyloids.	Zinc	73-75	metallothionein 3	Homo sapiens	132-136
28390674-2	2017	Zinc (Zn2+) is known to inhibit apoptosis induced by toxicants including Cd2+ both in vitro and in vivo.	Zinc	6-10	Cd2 molecule	Rattus norvegicus	73-76
28390674-3	2017	The mechanism of Zn2+-mediated protection from Cd2+-induced cytotoxicity is not established.	Zinc	17-21	Cd2 molecule	Rattus norvegicus	47-50
28390674-4	2017	In this study, we aimed to understand the effects of Zn2+ on Cd2+-induced cytotoxicity and apoptosis using PC12 cells.	Zinc	53-57	Cd2 molecule	Rattus norvegicus	61-64
28390674-5	2017	Cell viability and DNA fragmentation assays in PC12 cells exposed to Cd2+ and/or Zn2+ revealed that Cd2+ (5 and 10 mumol/L) alone induced significant cell death, and co-exposure to Zn2+ (5, 10, and 100 mumol/L) for 48 h had a protective effect.	Zinc	81-85	Cd2 molecule	Rattus norvegicus	100-103
28390674-5	2017	Cell viability and DNA fragmentation assays in PC12 cells exposed to Cd2+ and/or Zn2+ revealed that Cd2+ (5 and 10 mumol/L) alone induced significant cell death, and co-exposure to Zn2+ (5, 10, and 100 mumol/L) for 48 h had a protective effect.	Zinc	181-185	Cd2 molecule	Rattus norvegicus	69-72
28390674-5	2017	Cell viability and DNA fragmentation assays in PC12 cells exposed to Cd2+ and/or Zn2+ revealed that Cd2+ (5 and 10 mumol/L) alone induced significant cell death, and co-exposure to Zn2+ (5, 10, and 100 mumol/L) for 48 h had a protective effect.	Zinc	181-185	Cd2 molecule	Rattus norvegicus	100-103
28390674-7	2017	Addition of Zn2+ (10 and 100 mumol/L) reduced Cd2+-mediated cytotoxicity.	Zinc	12-16	Cd2 molecule	Rattus norvegicus	46-49
28390674-9	2017	Western blots showed that Zn2+ (10 and 100 mumol/L) suppressed Cd2+-induced apoptosis (10 mumol/L) by reducing cytochrome c release into the cytosol, and downregulating the proapoptotic protein, Bax.	Zinc	26-30	Cd2 molecule	Rattus norvegicus	63-66
28390674-10	2017	In addition, expression of caspase 9 was lower in Cd2+ (5 mumol/L)-treated PC12 cells when co-treated with Zn2+ (2 and 5 mumol/L).	Zinc	107-111	Cd2 molecule	Rattus norvegicus	50-53
28390674-11	2017	These findings suggest that the effective inhibition of Cd2+-induced apoptosis in PC12 cells by Zn2+ might be due to suppression of mitochondrial apoptosis pathway and inhibition of Cd2+-induced production of reactive oxygen species.	Zinc	96-100	Cd2 molecule	Rattus norvegicus	56-59
28390674-11	2017	These findings suggest that the effective inhibition of Cd2+-induced apoptosis in PC12 cells by Zn2+ might be due to suppression of mitochondrial apoptosis pathway and inhibition of Cd2+-induced production of reactive oxygen species.	Zinc	96-100	Cd2 molecule	Rattus norvegicus	182-185
28552173-5	2017	In THP-1 macrophage cell line and in human primary macrophages, Zn2+ at sub-toxic doses (30 muM) caused stimulation of TNF-alpha and IL-10 with different dynamics reaching the maximum peak at the zinc concentration 100 muM, before the cell death.	Zinc	64-68	interleukin 10	Homo sapiens	133-138
28101932-11	2017	Long-term application of high concentration of zinc(II) significantly enhanced cisplatin resistance, invasiveness, cellular antioxidant capacity, synthesis of glutathione, and expression of treatment resistance- and stemness-associated genes (SOX2, POU5F1, BIRC5).	Zinc	47-55	SRY-box transcription factor 2	Homo sapiens	243-247
28101932-11	2017	Long-term application of high concentration of zinc(II) significantly enhanced cisplatin resistance, invasiveness, cellular antioxidant capacity, synthesis of glutathione, and expression of treatment resistance- and stemness-associated genes (SOX2, POU5F1, BIRC5).	Zinc	47-55	baculoviral IAP repeat containing 5	Homo sapiens	257-262
28296060-3	2017	Herein, a novel monolithic optoelectronic device fabricated by a mask-free laser direct writing method is demonstrated in which in situ laser induced graphene-like materials are employed as lateral electrodes for flexible ZnS/SnO2 ultraviolet photodetectors.	Zinc	222-225	strawberry notch homolog 2	Homo sapiens	226-229
27940220-6	2017	ZIP4 knockdown in human keratinocytes down-regulates zinc (Zn) levels and the transcriptional activity of a key epidermal Zn-binding protein, DeltaNp63, and dysregulates epidermal differentiation in a reconstituted human skin model, resulting in the appearance of proliferating keratinocytes even in the uppermost layers of the skin.	Zinc	59-61	solute carrier family 39 member 4	Homo sapiens	0-4
27940220-8	2017	Our results suggest that ZIP4 is essential for maintaining human epidermal homeostasis through the regulation of Zn-dependent DeltaNp63 activity and can provide insight into the molecular mechanisms responsible for the cutaneous symptoms observed in Acrodermatitis enteropathica patients.	Zinc	113-115	solute carrier family 39 member 4	Homo sapiens	25-29
28290565-1	2017	Combinations of a neutral Pt(ii) organometallic tecton bearing two triphenylphosphine and two 3-ethynylpyridyl coordinating moieties in trans positions with MX2 complexes (M = Co(ii) and X = Cl- or Br- and M = Zn(ii) and X = Cl-) lead to the formation of isostructural 1D heterobimetallic coordination compounds.	Zinc	210-212	MX dynamin like GTPase 2	Homo sapiens	157-160
28322340-0	2017	Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells.	Zinc	32-36	transient receptor potential cation channel subfamily M member 2	Homo sapiens	45-50
28322340-2	2017	Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells.	Zinc	69-73	transient receptor potential cation channel subfamily M member 2	Homo sapiens	47-52
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	transient receptor potential cation channel subfamily M member 2	Homo sapiens	128-133
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	transient receptor potential cation channel subfamily M member 2	Homo sapiens	158-163
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	Zinc	115-119	transient receptor potential cation channel subfamily M member 2	Homo sapiens	158-163
28322340-8	2017	Activation of these TRPM2-depenent signalling mechanisms ultimately drives Zn2+-induced Ca2+ overloading and cell death.	Zinc	75-79	transient receptor potential cation channel subfamily M member 2	Homo sapiens	20-25
27765260-4	2017	Using the choice of the absorption line wings, the upper limit of the linear range increased up to 110mgL-1 for Mg, 200mgL-1 for Si and 13mgL-1 for Zn.	Zinc	148-150	LLGL scribble cell polarity complex component 1	Homo sapiens	102-107
28262877-5	2017	Spin-splitting and spin-degenerate bands are realized in Ti-, V-, Cr-, Mn-, Fe-, and Co- and Sc-, Ni-, Cu-, and Zn-adsorbed systems, respectively.	Zinc	112-114	spindlin 1	Homo sapiens	0-4
28262877-5	2017	Spin-splitting and spin-degenerate bands are realized in Ti-, V-, Cr-, Mn-, Fe-, and Co- and Sc-, Ni-, Cu-, and Zn-adsorbed systems, respectively.	Zinc	112-114	spindlin 1	Homo sapiens	19-23
28386184-4	2017	Under the optimal experimental conditions, no interference was observed for the determination of 100 ng mL-1 Ag+ in the presence of various cations below their maximum concentrations allowed in this method, for instance, 50 mug mL-1 for both Zn2+ and Cu2+, 80 mug mL-1 for Pb2+, 1000 mug mL-1 for Mn2+, and 100 mug mL-1 for both Cd2+ and Ni2+.	Zinc	242-246	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	104-111
27899481-8	2017	Increasing pancreatic Zn2+ (hZnT8WT) induced nucleoside diphosphate kinase B, and Zn2+ reduction (hZnT8RW) induced carboxypeptidase A1.	Zinc	82-86	carboxypeptidase A1, pancreatic	Mus musculus	115-134
28114997-4	2017	RESULTS: In the present study, we synthesized a kind of graphene-P-gp loaded with miR-122-InP@ZnS quantum dots nanocomposites (GPMQNs) that, in the presence of glutathione, provides controlled release of miR-122.	Zinc	94-97	microRNA 122	Homo sapiens	82-89
26965689-4	2017	Consistently, recent studies suggest that human ATP13A2 may preferably regulate Zn2+, while ATP13A2 from other species have different substrate selectivity.	Zinc	80-84	ATPase cation transporting 13A2	Homo sapiens	48-55
26965689-7	2017	Loss of functional ATP13A2 has been shown to induce Zn2+ dyshomeostasis.	Zinc	52-56	ATPase cation transporting 13A2	Homo sapiens	19-26
26965689-9	2017	Additionally, ATP13A2 appears to be involved in alpha-synuclein externalisation through its Zn2+-regulating activity.	Zinc	92-96	ATPase cation transporting 13A2	Homo sapiens	14-21
27930811-4	2017	We now show that HRG binds Zn2+ , Ni2+ , Cu2+ and Co2+ with micromolar affinities, but differing stoichiometries, and regulate the release of specific HRG fragments during proteolysis.	Zinc	27-31	histidine rich glycoprotein	Homo sapiens	17-20
27930811-5	2017	Furthermore, HRG binding to Zn2+ promotes HRG dimer formation in a Zn2+ -concentration- and pH-dependent manner.	Zinc	28-32	histidine rich glycoprotein	Homo sapiens	13-16
27930811-5	2017	Furthermore, HRG binding to Zn2+ promotes HRG dimer formation in a Zn2+ -concentration- and pH-dependent manner.	Zinc	28-32	histidine rich glycoprotein	Homo sapiens	42-45
27930811-5	2017	Furthermore, HRG binding to Zn2+ promotes HRG dimer formation in a Zn2+ -concentration- and pH-dependent manner.	Zinc	67-71	histidine rich glycoprotein	Homo sapiens	13-16
27930811-5	2017	Furthermore, HRG binding to Zn2+ promotes HRG dimer formation in a Zn2+ -concentration- and pH-dependent manner.	Zinc	67-71	histidine rich glycoprotein	Homo sapiens	42-45
28090201-0	2016	The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.	Zinc	42-50	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	152-156
28090201-5	2016	The NGF-induced TrkA internalization was slightly inhibited in the presence of Cu2+ and Zn2+ ions, whereas the metal ions elicited the NGF(1-14)-induced internalization of TrkA and no significant differences were found in the weak Ac-NGF(1-14)-induced receptor internalization.	Zinc	88-92	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	16-20
27756843-6	2016	Sirt1 S-nitrosation correlated with Zn2+ release from the conserved sirtuin Zn2+-tetrathiolate and a loss of alpha-helical structure without overall thermal destabilization of the enzyme.	Zinc	36-40	sirtuin 1	Homo sapiens	0-5
27756843-7	2016	Molecular dynamics simulations suggested that Zn2+ loss due to Sirt1 S-nitrosation results in repositioning of the tetrathiolate subdomain away from the rest of the catalytic domain, thereby disrupting the NAD+ and acetyl-lysine-binding sites.	Zinc	46-50	sirtuin 1	Homo sapiens	63-68
27756843-9	2016	Reversal of S-nitrosation resulted in full restoration of Sirt1 activity only in the presence of Zn2+, consistent with S-nitrosation of the Zn2+-tetrathiolate as the primary source of Sirt1 inhibition upon S-nitrosoglutathione treatment.	Zinc	97-101	sirtuin 1	Homo sapiens	58-63
26995290-4	2016	At mossy fiber-CA3 pyramidal cell synapses and Schaffer collateral-CA1 pyramidal cell synapses, which are zincergic, extracellular Zn2+ signaling leads to intracellular Zn2+ signaling and is involved in learning and memory.	Zinc	131-135	carbonic anhydrase 1	Homo sapiens	67-70
26995290-7	2016	It is possible that the degree and frequency of Zn2+ signaling, which determine the increased Zn2+ levels, modulates learning and memory as well as intracellular Ca2+ signaling.	Zinc	48-52	carbonic anhydrase 2	Homo sapiens	162-165
26995290-7	2016	It is possible that the degree and frequency of Zn2+ signaling, which determine the increased Zn2+ levels, modulates learning and memory as well as intracellular Ca2+ signaling.	Zinc	94-98	carbonic anhydrase 2	Homo sapiens	162-165
27886123-2	2016	AIE-DCD was found to afford satisfactory AIE response for specific detection of Zn2+ with a detection limit of 50 nM.	Zinc	80-84	dermcidin	Homo sapiens	4-7
27783504-3	2016	With regard to the active site, some PBGSs require Zn2+; a subset of those, including human PBGS, contain a constellation of cysteine residues that acts as a sink for the environmental toxin Pb2+.	Zinc	51-55	aminolevulinate dehydratase	Homo sapiens	37-41
27399209-0	2016	An extracellular Zn-only superoxide dismutase from Puccinia striiformis confers enhanced resistance to host-derived oxidative stress.	Zinc	17-19	SOD	Triticum aestivum	25-45
27399209-7	2016	Heterologous mutant complementation and biochemical characterization revealed that PsSOD1 encoded a Zn-only SOD.	Zinc	100-102	SOD	Triticum aestivum	85-88
27607901-1	2016	The homofullerene compound cis-2-C60 (CF2 )2 , which has an unusual kind of open/closed valence tautomerism undergoes consecutive regioselective hydrogenation at bridgehead carbon atoms upon reduction with Zn/Cu couple in H2 O-toluene mixture.	Zinc	206-208	ATPase H+ transporting accessory protein 1	Homo sapiens	38-41
27541598-4	2016	In this study, we report that CP binds Zn(II) at this site using a hexahistidine motif, completed by His103 and His105 of the S100A9 C-terminal tail and previously identified as the high-affinity Mn(II) and Fe(II) coordination site.	Zinc	39-45	S100 calcium binding protein A9	Homo sapiens	126-132
27541598-5	2016	Zn(II) binding at this unique site shields the S100A9 C-terminal tail from proteolytic degradation by proteinase K. X-ray absorption spectroscopy and Zn(II) competition titrations support the formation of a Zn(II)-His6 motif.	Zinc	0-6	S100 calcium binding protein A9	Homo sapiens	47-53
27541598-5	2016	Zn(II) binding at this unique site shields the S100A9 C-terminal tail from proteolytic degradation by proteinase K. X-ray absorption spectroscopy and Zn(II) competition titrations support the formation of a Zn(II)-His6 motif.	Zinc	150-156	S100 calcium binding protein A9	Homo sapiens	47-53
27653687-0	2016	IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.	Zinc	80-82	metallothionein 3	Homo sapiens	13-30
27653687-0	2016	IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.	Zinc	80-82	solute carrier family 30 member 4	Homo sapiens	36-43
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	72-74	solute carrier family 30 member 4	Homo sapiens	84-91
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	metallothionein 3	Homo sapiens	43-60
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	metallothionein 3	Homo sapiens	62-65
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	solute carrier family 30 member 4	Homo sapiens	84-91
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	metallothionein 3	Homo sapiens	43-60
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	metallothionein 3	Homo sapiens	62-65
27653687-3	2016	We show that interleukin (IL)-4 triggers a metallothionein 3 (MT3)- and Zn exporter SLC30A4-dependent increase in the labile Zn(2+) stores in macrophages and that intracellular pathogens can exploit this increase in Zn to survive.	Zinc	125-127	solute carrier family 30 member 4	Homo sapiens	84-91
27653687-4	2016	IL-4 regulates this pathway by shuttling extracellular Zn into macrophages and by activating cathepsins that act on MT3 to release bound Zn.	Zinc	137-139	metallothionein 3	Homo sapiens	116-119
27653687-7	2016	Thus, MT3 and SLC30A4 dictate the size of the labile Zn(2+) pool and promote the survival of a prototypical intracellular pathogen in M2 macrophages.	Zinc	53-59	metallothionein 3	Homo sapiens	6-9
27653687-7	2016	Thus, MT3 and SLC30A4 dictate the size of the labile Zn(2+) pool and promote the survival of a prototypical intracellular pathogen in M2 macrophages.	Zinc	53-59	solute carrier family 30 member 4	Homo sapiens	14-21
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Zinc	162-165	beta-secretase 1	Bos taurus	0-5
27458983-0	2016	Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.	Zinc	101-109	C-X-C motif chemokine receptor 4	Homo sapiens	16-21
27458983-5	2016	Concurrent density functional theory molecular modelling studies produced an energetic rationale for the unexpected [Zn(OAc)(H2 O)](+) coordination motif present in all of the Zn(2+) cross-bridged tetraazamacrocycle crystal structures, which differs from the chelating acetate [Zn(OAc)](+) structures of known unbridged and side-bridged tetraazamacrocyclic Zn(2+) -containing CXCR4 antagonists.	Zinc	117-119	C-X-C motif chemokine receptor 4	Homo sapiens	376-381
27458983-5	2016	Concurrent density functional theory molecular modelling studies produced an energetic rationale for the unexpected [Zn(OAc)(H2 O)](+) coordination motif present in all of the Zn(2+) cross-bridged tetraazamacrocycle crystal structures, which differs from the chelating acetate [Zn(OAc)](+) structures of known unbridged and side-bridged tetraazamacrocyclic Zn(2+) -containing CXCR4 antagonists.	Zinc	176-182	C-X-C motif chemokine receptor 4	Homo sapiens	376-381
27230230-5	2016	Furthermore, carboxypeptidase B and alpha-amylase activities were significantly lower in samples with reduced pancreatic Zn contents.	Zinc	121-123	carboxypeptidase B1	Sus scrofa	13-31
31968828-1	2016	A ZnII -based metal-organic framework (MOF), [Zn2 (bdp-CHO)2 ] (DMF)(CH3 CN)(H2 O)2 (BUT-31) is reported that was synthesized by the reaction between a newly designed aldehyde-tagged polypyrazole ligand 2,5-di(1H-pyrazol-4-yl)benzaldehyde (H2 bdp-CHO) and a zinc salt.	Zinc	2-6	EBP cholestenol delta-isomerase	Homo sapiens	55-60
26514573-5	2016	The results indicate that Fe-PILB has a good ability to resist co-existing anions and the low-pH condition of IPA and owns a relatively high-removal capacity of 80.42 and 25 % for OM, Cr(III), and Zn(II).	Zinc	197-199	methionine sulfoxide reductase B2	Homo sapiens	29-33
27107934-8	2016	These results suggest that zinc is a novel stimulant for CCK secretion through the activation of TRPA1 related to intracellular Zn(2+) and Ca(2+) mobilization.	Zinc	128-134	cholecystokinin	Rattus norvegicus	57-60
25764516-8	2016	Zn attenuated the expression of tyrosine hydroxylase (TH) and vesicular monoamine transporter-2 (VMAT-2) while augmented the expression of dopamine transporter (DAT) and heme oxygenase-1 (HO-1).	Zinc	0-2	solute carrier family 18 member A2	Rattus norvegicus	97-103
25764516-8	2016	Zn attenuated the expression of tyrosine hydroxylase (TH) and vesicular monoamine transporter-2 (VMAT-2) while augmented the expression of dopamine transporter (DAT) and heme oxygenase-1 (HO-1).	Zinc	0-2	heme oxygenase 1	Rattus norvegicus	170-186
26757944-0	2016	Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein.	Zinc	29-35	metallothionein 3	Homo sapiens	47-51
26757944-1	2016	Isothermal titration calorimetry (ITC) was used to quantify the thermodynamics of Pb(2+) and Zn(2+) binding to metallothionein-3 (MT-3).	Zinc	93-95	metallothionein 3	Homo sapiens	111-128
26757944-1	2016	Isothermal titration calorimetry (ITC) was used to quantify the thermodynamics of Pb(2+) and Zn(2+) binding to metallothionein-3 (MT-3).	Zinc	93-95	metallothionein 3	Homo sapiens	130-134
27095402-4	2016	Lam induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system.	Zinc	91-93	iron-regulated transporter 1	Arabidopsis thaliana	26-30
27068538-3	2016	Activation of TRPM2 channels, however, caused intracellular release of not only Ca(2+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2+) showed opposite effects.	Zinc	99-105	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
27068538-3	2016	Activation of TRPM2 channels, however, caused intracellular release of not only Ca(2+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2+) showed opposite effects.	Zinc	147-153	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
26364956-0	2016	Prolidase-Associated Trace Elements (Mn, Zn, Co, and Ni) in the Patients with Parkinson"s Disease.	Zinc	41-43	peptidase D	Homo sapiens	0-9
26364956-3	2016	In present study, we aimed to study the association of prolidase-associated trace elements, such as Co, Mn, Ni, and Zn in the plasma of patients with PD by inductively coupled plasma spectrometry.	Zinc	116-118	peptidase D	Homo sapiens	55-64
25682263-3	2016	Matrix metalloproteinase-9 (MMP-9), a member of the family of Zn(+2)-containing endoproteases, known to be expressed and secreted by astrocytes, is capable of degrading Abeta.	Zinc	62-68	matrix metallopeptidase 9	Homo sapiens	28-33
26808399-1	2016	The concentration, spatial distribution and source of 13-PM1 bound trace metals (Fe, Cu, Mn, Cr, Zn, Cd, Ni, K, Mg, Na, Ca, Pb and V) and adverse health effects of 5-PM1 bound trace metals (Mn, Zn, Ni, Cr and Cd) collected during foggy and non-foggy episodes are presented.	Zinc	97-99	transmembrane protein 11	Homo sapiens	57-60
27451749-0	2016	Synthesis and Photoluminescence Characteristics of CaIn2O4:Dy3+ Phosphors Co-Doped with Gd3+, Zn2+ or AI3+ Ions.	Zinc	94-98	calcineurin binding protein 1	Homo sapiens	51-55
27451749-3	2016	The luminescence intensities of CaIn2O4:0.6%Dy3+ were enhanced by 0.2% Gd3+ or 0.2% Zn2+ ions co-doping under 367 nm excitation, but lowered by co-doping with 0.2% Al3+ ions.	Zinc	84-88	calcineurin binding protein 1	Homo sapiens	32-36
27451749-4	2016	Furthermore, the chromaticity coordinates of CaIn2O4:0.6%Dy3+ can be tuned from the cold-white region to warm-white region with Gd3+ or Zn2+ ions co-doping.	Zinc	136-140	calcineurin binding protein 1	Homo sapiens	45-49
27451749-5	2016	These findings show that CaIn2O4:0.6%Dy3+,0.2% Gd3+, and CaIn2O4:0.6%Dy3+,0.2% Zn2+ have potential application value as new warm-white LED phosphors.	Zinc	79-83	calcineurin binding protein 1	Homo sapiens	25-29
27451749-5	2016	These findings show that CaIn2O4:0.6%Dy3+,0.2% Gd3+, and CaIn2O4:0.6%Dy3+,0.2% Zn2+ have potential application value as new warm-white LED phosphors.	Zinc	79-83	calcineurin binding protein 1	Homo sapiens	57-61
26918602-3	2016	Here we report that moderate and mild-ZD (6 and 12 mg Zn/kg diet) also induced esophageal hyperplasia, albeit less pronounced than induced by marked-ZD, with a 2-microRNA signature (miR-31, -146a).	Zinc	54-56	microRNA 31	Rattus norvegicus	182-188
26925211-9	2016	The GluC cleavage site is in close proximity to the His3Asp metal-binding site, which coordinates Zn(II) with high affinity, and Zn(II) chelation protects the S100A8 subunit from GluC cleavage.	Zinc	98-100	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	4-8
26925211-9	2016	The GluC cleavage site is in close proximity to the His3Asp metal-binding site, which coordinates Zn(II) with high affinity, and Zn(II) chelation protects the S100A8 subunit from GluC cleavage.	Zinc	129-131	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	179-183
27455754-2	2016	Morphology and structure of the ZnS microspheres are analyzed by SEM, TEM, XRD and N2 sorption technique, Gas sensing properties of the as-prepared ZnS sensor are also systematically investigated.	Zinc	32-35	MFT2	Homo sapiens	70-73
26758654-9	2016	mt2 induction of 20.5 +- 1.9-fold and 2.5 +- 0.8-fold change (mean +- SEM) was observed in larvae at the highest Zn(II) and nZnO concentrations (3 and 6 mg l(-1)), respectively.	Zinc	113-115	metallothionein 2	Danio rerio	0-3
26574547-4	2016	Zn(2+)-mediated phosphorylation of STEP61 at multiple sites (hyperphosphorylation) was induced by the up-regulation of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activation of cAMP-dependent PKA (protein kinase A).	Zinc	0-2	brain derived neurotrophic factor	Homo sapiens	119-151
26574547-4	2016	Zn(2+)-mediated phosphorylation of STEP61 at multiple sites (hyperphosphorylation) was induced by the up-regulation of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activation of cAMP-dependent PKA (protein kinase A).	Zinc	0-2	brain derived neurotrophic factor	Homo sapiens	153-157
26574547-6	2016	Consistent with these findings we also show that BDNF/Trk/PKA mediated signaling is required for Zn(2+)-induced phosphorylation of extracellular regulated kinase 2 (ERK2), a substrate of STEP that is involved in Zn(2+)-dependent neurotoxicity.	Zinc	97-103	brain derived neurotrophic factor	Homo sapiens	49-53
26728511-12	2016	The differences in Zn localization mirrored the relative abundance of the Zn transporter ZnT2; T47D cells over-expressed ZnT2, whereas MDA-MB-231 cells did not express ZnT2 protein due to proteasomal degradation.	Zinc	19-21	solute carrier family 30 member 2	Homo sapiens	89-93
26728511-12	2016	The differences in Zn localization mirrored the relative abundance of the Zn transporter ZnT2; T47D cells over-expressed ZnT2, whereas MDA-MB-231 cells did not express ZnT2 protein due to proteasomal degradation.	Zinc	19-21	solute carrier family 30 member 2	Homo sapiens	121-125
26728511-12	2016	The differences in Zn localization mirrored the relative abundance of the Zn transporter ZnT2; T47D cells over-expressed ZnT2, whereas MDA-MB-231 cells did not express ZnT2 protein due to proteasomal degradation.	Zinc	19-21	solute carrier family 30 member 2	Homo sapiens	121-125
26684598-2	2016	Namely, in the presence of linear three-atom SCN(-), 1a was degraded into two 23-membered [1 + 1] Schiff-base macrocyclic complexes simultaneously (mononuclear Zn(II) complex 2 and dinuclear Zn(II) complex 3).	Zinc	160-166	sorcin	Homo sapiens	45-55
26684598-2	2016	Namely, in the presence of linear three-atom SCN(-), 1a was degraded into two 23-membered [1 + 1] Schiff-base macrocyclic complexes simultaneously (mononuclear Zn(II) complex 2 and dinuclear Zn(II) complex 3).	Zinc	191-197	sorcin	Homo sapiens	45-55
27251508-3	2016	In the current study, we evaluated the protective effect of zinc (Zn) against CCl4-induced nephrotoxicity.	Zinc	66-68	chemokine (C-C motif) ligand 4	Mus musculus	78-82
27251508-6	2016	Our results showed that Zn pretreatment significantly decreased creatinine and blood urea nitrogen levels and reduced renal histopathological damage at 6 h post-CCl4 injection, observations consistent with enhanced antioxidative activity in the kidney.	Zinc	24-26	chemokine (C-C motif) ligand 4	Mus musculus	161-165
27251508-7	2016	Moreover, kidney MT levels in the Zn+CCl4-treated group decreased by greater than 70% compared with levels in the Zn-alone group, implying that MT was consumed by CCl4-induced radicals.	Zinc	34-36	chemokine (C-C motif) ligand 4	Mus musculus	163-167
27251508-7	2016	Moreover, kidney MT levels in the Zn+CCl4-treated group decreased by greater than 70% compared with levels in the Zn-alone group, implying that MT was consumed by CCl4-induced radicals.	Zinc	114-116	chemokine (C-C motif) ligand 4	Mus musculus	37-41
27251508-8	2016	These findings suggest that prophylaxis with Zn protects mice from CCl4-induced acute nephrotoxicity, presumably by induction of MT, which in turn scavenges radicals induced by CCl4 exposure.	Zinc	45-47	chemokine (C-C motif) ligand 4	Mus musculus	67-71
27251508-8	2016	These findings suggest that prophylaxis with Zn protects mice from CCl4-induced acute nephrotoxicity, presumably by induction of MT, which in turn scavenges radicals induced by CCl4 exposure.	Zinc	45-47	chemokine (C-C motif) ligand 4	Mus musculus	177-181
26415522-4	2016	Both syn-[Zn(L(Ph) OMe)Cl2 ] and anti-[Zn(L(Ph) OMe)Cl2 ] were characterized using NMR spectroscopy and mass spectrometry.	Zinc	10-12	synemin	Homo sapiens	5-8
26415522-5	2016	Solid-state structures revealed that syn-[Zn(L(Ph) OMe)Cl2 ] adopted a square pyramidal geometry while anti-[Zn(L(Ph) OMe)Cl2 ] possesses a trigonal bipyramidal geometry around the Zn centers.	Zinc	42-44	synemin	Homo sapiens	37-40
26415522-7	2016	Syn complexes were isolated as major products with Zn(II) and Cu(II) , and anti complexes were found to be major products with Ni(II) and Cd(II) .	Zinc	51-57	synemin	Homo sapiens	0-3
26504078-0	2015	Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.	Zinc	15-19	solute carrier family 6 member 3	Homo sapiens	50-70
26504078-2	2015	The dopamine transporter carries an endogenous binding site for Zn(2+), but the nature of the Zn(2+)-dependent modulation has remained elusive: both, inhibition and stimulation of DAT have been reported.	Zinc	64-66	solute carrier family 6 member 3	Homo sapiens	4-24
26504078-3	2015	Here, we exploited the high time resolution of patch-clamp recordings to examine the effects of Zn(2+) on the transport cycle of DAT: we recorded peak currents associated with substrate translocation and steady-state currents reflecting the forward transport mode of DAT.	Zinc	96-98	solute carrier family 6 member 3	Homo sapiens	129-132
26504078-5	2015	The parsimonious explanation is preferential binding of Zn(2+) to the outward facing conformation of DAT, which allows for an allosteric activation of DAT, in both, the forward transport mode and substrate exchange mode.	Zinc	56-58	solute carrier family 6 member 3	Homo sapiens	101-104
26504078-5	2015	The parsimonious explanation is preferential binding of Zn(2+) to the outward facing conformation of DAT, which allows for an allosteric activation of DAT, in both, the forward transport mode and substrate exchange mode.	Zinc	56-58	solute carrier family 6 member 3	Homo sapiens	151-154
26504078-6	2015	We directly confirmed that Zn(2+) dissociated more rapidly from the inward- than from the outward-facing state of DAT.	Zinc	27-33	solute carrier family 6 member 3	Homo sapiens	114-117
26504078-7	2015	Finally, we formulated a kinetic model for the action of Zn(2+) on DAT that emulated all current experimental observations and accounted for all previous (in part contradictory) findings.	Zinc	57-59	solute carrier family 6 member 3	Homo sapiens	67-70
26504078-8	2015	Importantly, the model predicts that the intracellular Na(+) concentration determines whether substrate uptake by DAT is stimulated or inhibited by Zn(2+).	Zinc	148-150	solute carrier family 6 member 3	Homo sapiens	114-117
26115687-8	2015	Of the inhibitors tested, N-ethylmaleimide, Zn ion and Ub aldehyde revealed a dose-dependent inhibition of USP47.	Zinc	44-46	ubiquitin specific peptidase 47	Homo sapiens	107-112
26297535-3	2015	We focused these studies in investigating whether activation of the mTOR signaling pathway is also a necessary mechanism of the antidepressant-like activity of Zn.	Zinc	160-162	mechanistic target of rapamycin kinase	Rattus norvegicus	68-72
26297535-4	2015	We observed that a single injection of Zn (5 mg/kg) induced an increase in the phosphorylation of mTOR and p70S6K 30 min and 3 h after Zn treatment at time points when Zn produced also an antidepressant-like effect in the forced swim test (FST).	Zinc	39-41	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
26297535-4	2015	We observed that a single injection of Zn (5 mg/kg) induced an increase in the phosphorylation of mTOR and p70S6K 30 min and 3 h after Zn treatment at time points when Zn produced also an antidepressant-like effect in the forced swim test (FST).	Zinc	135-137	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
26297535-4	2015	We observed that a single injection of Zn (5 mg/kg) induced an increase in the phosphorylation of mTOR and p70S6K 30 min and 3 h after Zn treatment at time points when Zn produced also an antidepressant-like effect in the forced swim test (FST).	Zinc	135-137	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
26297535-5	2015	Furthermore, Zn administered 3 h before the decapitation increased the level of brain derived neurotrophic factor (BDNF), GluA1 and synapsin I.	Zinc	13-15	brain-derived neurotrophic factor	Rattus norvegicus	80-113
26297535-5	2015	Furthermore, Zn administered 3 h before the decapitation increased the level of brain derived neurotrophic factor (BDNF), GluA1 and synapsin I.	Zinc	13-15	brain-derived neurotrophic factor	Rattus norvegicus	115-119
26297535-5	2015	Furthermore, Zn administered 3 h before the decapitation increased the level of brain derived neurotrophic factor (BDNF), GluA1 and synapsin I.	Zinc	13-15	synapsin I	Rattus norvegicus	132-142
26297535-6	2015	An elevated level of GluA1 and synapsin I was still observed 24 h after the Zn treatment, although Zn did not produce any effects in the FST at that time point.	Zinc	76-78	synapsin I	Rattus norvegicus	31-41
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	190-192	mechanistic target of rapamycin kinase	Rattus norvegicus	51-55
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	219-221	mechanistic target of rapamycin kinase	Rattus norvegicus	51-55
26297535-7	2015	We also observed that pretreatment with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), H-89 (PKA inhibitor) and GF109203X (PKC inhibitor) blocked the antidepressant-like effect of Zn in FST in rats and blocks Zn-induced activation of mTOR signaling proteins (analyzed 30 min after Zn administration).	Zinc	219-221	mechanistic target of rapamycin kinase	Rattus norvegicus	51-55
26297535-8	2015	These studies indicated that the antidepressant-like activity of Zn depends on the activation of mTOR signaling and other signaling pathways related to neuroplasticity, which can indirectly modulate mTOR function.	Zinc	65-67	mechanistic target of rapamycin kinase	Rattus norvegicus	97-101
26297535-8	2015	These studies indicated that the antidepressant-like activity of Zn depends on the activation of mTOR signaling and other signaling pathways related to neuroplasticity, which can indirectly modulate mTOR function.	Zinc	65-67	mechanistic target of rapamycin kinase	Rattus norvegicus	199-203
25910898-2	2015	The aim of this paper was to investigate the effect of intracellular Zn(2+) concentration ([Zn(2+)]i) in hypoxia-induced regulation of metalloproteinases (MMPs) and extracellular matrix (ECM) production in NP cells.	Zinc	69-75	matrix metallopeptidase 13	Rattus norvegicus	155-159
25910898-10	2015	Both an intracellular Zn(2+) chelator and hypoxia prevented the increase in MMP-13 mRNA expression.	Zinc	22-24	matrix metallopeptidase 13	Rattus norvegicus	76-82
25910898-12	2015	In conclusion, decrease of Zn(2+) influx mediates the protective role of hypoxia on ECM and MMP-13 expression.	Zinc	27-33	matrix metallopeptidase 13	Rattus norvegicus	92-98
26306426-8	2015	Mutant analysis revealed that ZIP9 is involved in uptake of Zn by the roots, and the mutant lacking ZIP9 was significantly more sensitive to Zn depletion than the wild-type.	Zinc	60-62	ZIP metal ion transporter family	Arabidopsis thaliana	30-34
26306426-8	2015	Mutant analysis revealed that ZIP9 is involved in uptake of Zn by the roots, and the mutant lacking ZIP9 was significantly more sensitive to Zn depletion than the wild-type.	Zinc	60-62	ZIP metal ion transporter family	Arabidopsis thaliana	100-104
26306426-8	2015	Mutant analysis revealed that ZIP9 is involved in uptake of Zn by the roots, and the mutant lacking ZIP9 was significantly more sensitive to Zn depletion than the wild-type.	Zinc	141-143	ZIP metal ion transporter family	Arabidopsis thaliana	30-34
26306426-8	2015	Mutant analysis revealed that ZIP9 is involved in uptake of Zn by the roots, and the mutant lacking ZIP9 was significantly more sensitive to Zn depletion than the wild-type.	Zinc	141-143	ZIP metal ion transporter family	Arabidopsis thaliana	100-104
26306426-9	2015	These results demonstrate that bZIP19 mainly contributes to expression of genes, such as ZIP9, under Zn-deficient conditions.	Zinc	101-103	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	31-37
26306426-9	2015	These results demonstrate that bZIP19 mainly contributes to expression of genes, such as ZIP9, under Zn-deficient conditions.	Zinc	101-103	ZIP metal ion transporter family	Arabidopsis thaliana	89-93
26344097-1	2015	BRCC36 is a Zn(2+)-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition.	Zinc	12-14	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	0-6
25801306-4	2015	Here, we show that the Zn-binding metallothionein (MT) proteins are essential for the FceRI-induced basophil production of IL-4.	Zinc	23-25	membrane-spanning 4-domains, subfamily A, member 2	Mus musculus	86-91
26026913-9	2015	Ziram increased the population of annexin V-positive cells in a Zn(2+)-dependent manner.	Zinc	64-70	annexin A5	Rattus norvegicus	34-43
26134396-1	2015	ATP13A2 is a lysosomal P-type transport ATPase that has been implicated in Kufor-Rakeb syndrome and Parkinson"s disease (PD), providing protection against alpha-synuclein, Mn(2+), and Zn(2+) toxicity in various model systems.	Zinc	184-186	ATPase cation transporting 13A2	Homo sapiens	0-7
26059373-5	2015	The test showed that Zn intake in women significantly correlated with reduced systolic blood pressure (SBP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gamma-GPT), and homeostasis model assessment-insulin resistance (HOMA-IR).	Zinc	21-23	inactive glutathione hydrolase 2	Homo sapiens	141-170
26053888-3	2015	Spin dependent electrical transport is studied on Fe3O4/ZnS nanocomposites with different shell thickness, and a large magnetoresistance (MR) ratio is observed under the magnetic field of 1.0 T at room temperature and 100 K for the compacted sample by Fe3O4/ZnS nanocomposites, which is 50% larger than that of sample with pure Fe3O4 particles, indicating that the enhanced MR is contributed from the spin injection between Fe3O4 and ZnS layer.	Zinc	258-261	spindlin 1	Homo sapiens	0-4
25564338-7	2015	Both MMP-2 and MMP-9 required divalent ions Ca and Zn for its activity and MMP-9 was more active at higher Ca/Zn ratio.	Zinc	51-53	matrix metallopeptidase 9	Homo sapiens	15-20
25564338-7	2015	Both MMP-2 and MMP-9 required divalent ions Ca and Zn for its activity and MMP-9 was more active at higher Ca/Zn ratio.	Zinc	110-112	matrix metallopeptidase 9	Homo sapiens	75-80
25869134-4	2015	Domain homology analysis revealed that MG53 contains two Zn(2+)-binding motifs.	Zinc	57-63	tripartite motif containing 72	Homo sapiens	39-43
25869134-5	2015	Here, we show that Zn(2+) binding to MG53 is indispensable to assembly of the cell membrane repair machinery.	Zinc	19-25	tripartite motif containing 72	Homo sapiens	37-41
25869134-6	2015	Live cell imaging illustrated that Zn(2+) entry from extracellular space is essential for translocation of MG53-containing vesicles to the acute membrane injury sites for formation of a repair patch.	Zinc	35-41	tripartite motif containing 72	Homo sapiens	107-111
25869134-7	2015	The effect of Zn(2+) on membrane repair is abolished in mg53(-/-) muscle fibers, suggesting that MG53 functions as a potential target for Zn(2+) during membrane repair.	Zinc	14-16	tripartite motif containing 72	Homo sapiens	56-60
25869134-7	2015	The effect of Zn(2+) on membrane repair is abolished in mg53(-/-) muscle fibers, suggesting that MG53 functions as a potential target for Zn(2+) during membrane repair.	Zinc	14-16	tripartite motif containing 72	Homo sapiens	97-101
25869134-7	2015	The effect of Zn(2+) on membrane repair is abolished in mg53(-/-) muscle fibers, suggesting that MG53 functions as a potential target for Zn(2+) during membrane repair.	Zinc	138-140	tripartite motif containing 72	Homo sapiens	56-60
25869134-7	2015	The effect of Zn(2+) on membrane repair is abolished in mg53(-/-) muscle fibers, suggesting that MG53 functions as a potential target for Zn(2+) during membrane repair.	Zinc	138-140	tripartite motif containing 72	Homo sapiens	97-101
25869134-8	2015	Mutagenesis studies suggested that both RING and B-box motifs of MG53 constitute Zn(2+)-binding domains that contribute to MG53-mediated membrane repair.	Zinc	81-87	tripartite motif containing 72	Homo sapiens	65-69
25869134-8	2015	Mutagenesis studies suggested that both RING and B-box motifs of MG53 constitute Zn(2+)-binding domains that contribute to MG53-mediated membrane repair.	Zinc	81-87	tripartite motif containing 72	Homo sapiens	123-127
25869134-9	2015	Overall, this study establishes a base for Zn(2+) interaction with MG53 in protection against injury to the cell membrane.	Zinc	43-45	tripartite motif containing 72	Homo sapiens	67-71
25902526-1	2015	Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O mechanism to catalyze the reversible hydration of CO2.	Zinc	44-46	carbonic anhydrase 2	Homo sapiens	6-27
25880464-5	2015	ESI-MS and (1)H NMR studies elucidated different transmetalation mechanisms for the two cases: While a Zn(2+)-to-Fe(2+) transmetalation occurs by the stepwise exchange of single ions on the helicate L3Zn3(OTf)6 at room temperature, this mechanism is almost inoperative for the Fe(2+)-to-Zn(2+) transmetalation in L3Fe3(OTf)6, which is kinetically trapped at room temperature.	Zinc	103-105	POU class 3 homeobox 1	Homo sapiens	199-210
25880464-5	2015	ESI-MS and (1)H NMR studies elucidated different transmetalation mechanisms for the two cases: While a Zn(2+)-to-Fe(2+) transmetalation occurs by the stepwise exchange of single ions on the helicate L3Zn3(OTf)6 at room temperature, this mechanism is almost inoperative for the Fe(2+)-to-Zn(2+) transmetalation in L3Fe3(OTf)6, which is kinetically trapped at room temperature.	Zinc	103-105	POU class 3 homeobox 1	Homo sapiens	313-324
25575748-10	2015	The levels of MT mRNA in the livers and kidneys of tilapia might therefore be used as biomarkers of exposure to Cd(2+), Cu(2+) and Zn(2+) in water of various salinities.	Zinc	131-133	metallothionein	Oreochromis niloticus	14-16
25604665-6	2015	Higher percentages of CD28 expression in CD4(+) and CD8(+) T cell populations were observed in control and infected Zn-treated group as compared to untreated ones.	Zinc	116-118	Cd4 molecule	Rattus norvegicus	41-44
25835329-6	2015	Subsequently, we tested the effect of Cu(2+) and Zn(2+) on the binding of heparin and sorLA to APP E2 using a chromatographic technique and surface plasmon resonance.	Zinc	49-51	sortilin related receptor 1	Homo sapiens	86-91
25618524-1	2015	Zinc transporter 2 (ZnT2) is one of the cellular factors responsible for Zn homeostasis.	Zinc	20-22	solute carrier family 30 member 2	Homo sapiens	0-18
25618524-2	2015	Upon Zn overload, ZnT2 reduces cellular Zn by transporting it into excretory vesicles.	Zinc	5-7	solute carrier family 30 member 2	Homo sapiens	18-22
25618524-4	2015	Zn induces hZnT2 expression in dose- and time-dependent manners.	Zinc	0-2	solute carrier family 30 member 2	Homo sapiens	11-16
25618524-10	2015	Mutation or deletion of this ZEB binding element elevates the basal and Zn-induced hZnT2 promoter activities.	Zinc	72-74	solute carrier family 30 member 2	Homo sapiens	83-88
25618524-12	2015	In MCF-7 (ZEB-deficient) cells, expression of ZEB proteins attenuates the Zn-induced hZnT2 expression.	Zinc	74-76	solute carrier family 30 member 2	Homo sapiens	85-90
25605573-2	2015	The anti and syn selectivity can be modulated by the sizes of sulfonamides to yield E- and Z-configured zinc(II) dienolates selectively.	Zinc	104-112	synemin	Homo sapiens	13-16
25542118-2	2015	The rationale behind this study was to demonstrate that presence of small quantities of Zn(2+) ions doped in HA nanoparticles can improve biocompatibility of PCL/Ch blends.	Zinc	88-90	PHD finger protein 1	Homo sapiens	158-161
25623240-7	2015	Interestingly, BmDNMT-1 formed a complex with DNA in the presence or absence of methyl group donor, S-Adenosylmethionine (AdoMet) and the AdoMet-dependent complex formation was facilitated by Zn(2+) and Mn(2+).	Zinc	192-194	DNA cytosine-5 methyltransferase	Bombyx mori	15-23
25741436-0	2015	Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder.	Zinc	0-2	solute carrier family 6 member 3	Homo sapiens	49-69
25741436-3	2015	Here, we report that Zn(2+) reverses, at least in part, the functional deficits of ASD-associated hDAT variant T356M.	Zinc	21-23	solute carrier family 6 member 3	Homo sapiens	98-102
25741436-4	2015	These data suggest that the molecular mechanism targeted by Zn(2+) to restore partial function in hDAT T356M may be a novel therapeutic target to rescue functional deficits in hDAT variants associated with ASD.	Zinc	60-62	solute carrier family 6 member 3	Homo sapiens	98-102
25741436-4	2015	These data suggest that the molecular mechanism targeted by Zn(2+) to restore partial function in hDAT T356M may be a novel therapeutic target to rescue functional deficits in hDAT variants associated with ASD.	Zinc	60-62	solute carrier family 6 member 3	Homo sapiens	176-180
25486072-6	2015	The energetically favored Zn chelation sites of the 1:1 complex were found to be either the C-3 O(-) and CO-4 or C-5 O(-) and CO-4 sites, depending on the functional used, for quercetin and the C-5 O(-) and CO-4 sites for luteolin.	Zinc	26-28	complement C3	Homo sapiens	92-95
26504859-12	2015	Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects.	Zinc	0-2	interleukin 17A	Homo sapiens	20-25
26504859-16	2015	CONCLUSIONS: This study demonstrates that Zn modulates IL-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic HCV.	Zinc	42-44	interleukin 17A	Homo sapiens	55-60
25353308-0	2015	Plasma free fatty acid levels influence Zn(2+) -dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin.	Zinc	40-46	histidine rich glycoprotein	Homo sapiens	58-85
25353308-2	2015	HRG associates with Zn(2+) to stimulate HRG-heparin complex formation.	Zinc	20-22	histidine rich glycoprotein	Homo sapiens	0-3
25353308-2	2015	HRG associates with Zn(2+) to stimulate HRG-heparin complex formation.	Zinc	20-22	histidine rich glycoprotein	Homo sapiens	40-43
25353308-5	2015	Thus, high levels of circulating FFAs, as are associated with diabetes, obesity, and cancer, may increase the proportion of plasma Zn(2+) associated with HRG, contributing to an increased risk of thrombotic disease.	Zinc	131-133	histidine rich glycoprotein	Homo sapiens	154-157
25353308-6	2015	OBJECTIVES: To characterize Zn(2+) binding by HRG, examine the influence that FFAs have on Zn(2+) binding by HSA, and establish whether FFA-mediated displacement of Zn(2+) from HSA may influence HRG-heparin complex formation.	Zinc	28-34	histidine rich glycoprotein	Homo sapiens	46-49
25353308-7	2015	METHODS: Zn(2+) binding to HRG and to HSA in the presence of different FFA (myristate) concentrations were examined by isothermal titration calorimetry (ITC) and the formation of HRG-heparin complexes in the presence of different Zn(2+) concentrations by both ITC and ELISA.	Zinc	9-15	histidine rich glycoprotein	Homo sapiens	27-30
25353308-9	2015	Also Zn(2+) binding was shown to increase the affinity with which HRG interacts with unfractionated heparins, but had no effect on its interaction with low molecular weight heparin (~ 6850 Da).	Zinc	5-11	histidine rich glycoprotein	Homo sapiens	66-69
25448360-1	2014	Matrix metalloproteinases (MMPs) constitute a large family of Zn(2+) and Ca(2+) dependent endopeptidases implicated in tissue remodeling and chronic inflammation.	Zinc	62-64	matrix metallopeptidase 9	Homo sapiens	27-31
25429618-0	2014	TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia.	Zinc	52-56	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
25429618-2	2014	Postischemic ROS generation and an increase in the cytosolic Zn(2+) level ([Zn(2+)]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechanisms are not fully understood.	Zinc	61-67	carbonic anhydrase 1	Homo sapiens	110-113
25429618-2	2014	Postischemic ROS generation and an increase in the cytosolic Zn(2+) level ([Zn(2+)]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechanisms are not fully understood.	Zinc	61-63	carbonic anhydrase 1	Homo sapiens	110-113
25429618-4	2014	Using in vivo and in vitro models of ischemia-reperfusion, we showed that genetic knockout of TRPM2 strongly prohibited the delayed increase in the [Zn(2+)]c, ROS generation, CA1 pyramidal neuronal death and postischemic memory impairment.	Zinc	149-155	transient receptor potential cation channel subfamily M member 2	Homo sapiens	94-99
25375834-4	2014	The results of simulations based on the quantum mechanics/molecular mechanics (QM/MM) approach and Car-Parrinello molecular dynamics with QM/MM potentials demonstrate that, upon binding of Regasepin1, a known MMP-9 inhibitor, the Zn(2+)(His3) structural element is rearranged to the Zn(2+)(Cys2His2) zinc finger motif, in which two Cys residues are borrowed from the ligand.	Zinc	230-236	matrix metallopeptidase 9	Homo sapiens	209-214
25375834-4	2014	The results of simulations based on the quantum mechanics/molecular mechanics (QM/MM) approach and Car-Parrinello molecular dynamics with QM/MM potentials demonstrate that, upon binding of Regasepin1, a known MMP-9 inhibitor, the Zn(2+)(His3) structural element is rearranged to the Zn(2+)(Cys2His2) zinc finger motif, in which two Cys residues are borrowed from the ligand.	Zinc	230-235	matrix metallopeptidase 9	Homo sapiens	209-214
25402564-5	2014	delta-ALA-D inhibition was completely restored by addition of dithiotreitol (DTT) and partly by ZnCl2, demonstrating that the inhibition occurs by oxidation of thiol groups and by displacement of the Zn (II), which can be explained by the presence of chemical elements found in the constitution of pesticides.	Zinc	96-98	aminolevulinate dehydratase	Homo sapiens	0-11
25517751-4	2014	In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B.	Zinc	30-32	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	84-88
24436082-4	2014	The emission wavelength of NAC-capped CdTe QDs could reach 700 nm in 5 min by controlling the reaction temperature, and the resultant CdTe/CdS/ZnS core-multishell QDs could achieve the highest quantum yields up to 74% with robust photostability.	Zinc	143-146	X-linked Kx blood group	Homo sapiens	27-30
24752528-8	2014	In strain cia3, defective in the lumenal carbonic anhydrase (CA), the cell quotas of P, S, Ca, Mn, Fe, and Zn were about 5-fold higher at low CO2 than at high CO2.	Zinc	107-109	uncharacterized protein	Chlamydomonas reinhardtii	41-59
24752528-8	2014	In strain cia3, defective in the lumenal carbonic anhydrase (CA), the cell quotas of P, S, Ca, Mn, Fe, and Zn were about 5-fold higher at low CO2 than at high CO2.	Zinc	107-109	uncharacterized protein	Chlamydomonas reinhardtii	61-63
24862443-5	2014	Molecular and cellular osteogenic activities demonstrate that rBMSCs cultured on the Zn-implanted coatings have higher ALP activity and up-regulated osteogenic-related genes (OCN, Col-I, ALP, Runx2) compared to the bulk-doped Zn coatings and controls.	Zinc	85-87	PDZ and LIM domain 3	Rattus norvegicus	119-122
24862443-5	2014	Molecular and cellular osteogenic activities demonstrate that rBMSCs cultured on the Zn-implanted coatings have higher ALP activity and up-regulated osteogenic-related genes (OCN, Col-I, ALP, Runx2) compared to the bulk-doped Zn coatings and controls.	Zinc	85-87	PDZ and LIM domain 3	Rattus norvegicus	187-190
24824562-10	2014	The ability of both Atox1 and WD4 to bind zinc ions may not be a problem in vivo due to the presence of specific transport chains for Cu and Zn ions.	Zinc	141-143	antioxidant 1 copper chaperone	Homo sapiens	20-25
24793162-6	2014	The development of novel assay conditions to investigate zinc inhibition of PTP1B provides estimates of about 5.6 nM affinity for inhibitory zinc(II) ions.	Zinc	141-149	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	76-81
24855944-8	2014	These findings suggest that TRPM7-mediated modulation of intracellular Zn(2+) concentration couples ion-channel signaling to epigenetic chromatin covalent modifications that affect gene expression patterns.	Zinc	71-77	transient receptor potential cation channel subfamily M member 7	Homo sapiens	28-33
25007631-0	2014	[Study of the Mn-doped ZnS quantum dots as the phosphorescence probes to detect the micro-quantity Hg2+].	Zinc	23-26	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	99-102
25007631-2	2014	Utilizing the strong quenching effect of Hg2+ to the phosphorescence of the ZnS: Mn quantum dots, the method to detect micro-quantity Hg2+ in water was established by using the quantum dots as the phosphorescence probes.	Zinc	76-79	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	41-44
25007631-2	2014	Utilizing the strong quenching effect of Hg2+ to the phosphorescence of the ZnS: Mn quantum dots, the method to detect micro-quantity Hg2+ in water was established by using the quantum dots as the phosphorescence probes.	Zinc	76-79	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	134-137
24584463-6	2014	The extracellular region of each protomer coordinated a Zn(2+), thus suggesting that Zn(2+) stabilizes the resting state of Hv1 by competing for acidic residues that otherwise form salt bridges with voltage-sensing positive charges on S4.	Zinc	85-87	hepatitis virus (MHV-2) susceptibility	Mus musculus	124-127
24677230-5	2014	A bifunctional activation model of the chiral Zn(OTf)2/bis(oxazoline) complex was proposed based on control experiments, wherein the ZnII moiety serves as a Lewis acid and the N atom of the free NH group acts as a Lewis base by a hydrogen-bonding interaction.	Zinc	133-137	POU class 2 homeobox 2	Homo sapiens	49-54
24479872-2	2014	MT3 acts both intracellularly and extracellularly in this organ, performing functions related to neuronal growth and physiological metal (Zn and Cu) handling.	Zinc	138-140	metallothionein 3	Homo sapiens	0-3
24402766-5	2014	As a result, the reductive coupling reaction between aliphatic and aromatic aldehydes by using a catalytic amount of 1cis in the presence of Me3 SiCl and Zn provided the corresponding cross-coupled 1,2-diol in good yields with high cross-selectivity.	Zinc	154-156	malic enzyme 3	Homo sapiens	141-144
24111988-6	2014	We also identified the active-site cysteine in glutathione S-transferase omega-1 (GSTO1) as a potential Zn(2+)-chelation site, albeit with lower metal affinity relative to SORD.	Zinc	104-106	glutathione S-transferase omega 1	Homo sapiens	47-80
24111988-6	2014	We also identified the active-site cysteine in glutathione S-transferase omega-1 (GSTO1) as a potential Zn(2+)-chelation site, albeit with lower metal affinity relative to SORD.	Zinc	104-106	glutathione S-transferase omega 1	Homo sapiens	82-87
24111988-7	2014	Treatment of recombinant GSTO1 with Zn(2+) ions results in a dose-dependent decrease in GSTO1 activity.	Zinc	36-38	glutathione S-transferase omega 1	Homo sapiens	25-30
24111988-7	2014	Treatment of recombinant GSTO1 with Zn(2+) ions results in a dose-dependent decrease in GSTO1 activity.	Zinc	36-38	glutathione S-transferase omega 1	Homo sapiens	88-93
24251537-10	2013	This study thus defines RicA as a Zn(2+)-binding gamma-carbonic anhydrase-like protein that binds the human membrane fusion/trafficking protein Rab2 with low micromolar affinity in vitro.	Zinc	34-40	RAB2A, member RAS oncogene family	Homo sapiens	144-148
23823484-3	2013	The present study evaluated whether the impairments caused by gestational and lactational Zn deficiency are mediated by the hippocampal calmodulin-dependent protein kinase II alpha (alpha-CaMKII)/brain-derived neurotrophic factor (BDNF) signalling pathway as well as whether they can be restored by postnatal Zn supplementation.	Zinc	90-92	brain-derived neurotrophic factor	Rattus norvegicus	196-229
23823484-10	2013	Our findings suggest that the alpha-CaMKII/BDNF signalling pathway may be involved in Zn deficiency-induced cognitive and synaptic impairments.	Zinc	86-88	brain-derived neurotrophic factor	Rattus norvegicus	43-47
23865749-8	2013	AhPDF1s and AtPDF1s were able to confer Zn tolerance and AhPDF1s also displayed antifungal activity.	Zinc	40-42	protodermal factor 1	Arabidopsis thaliana	12-18
23865749-12	2013	A constitutive increase in AhPDF1 transcript accumulation is proposed to be an evolutionary innovation co-opting the promiscuous PDF1 protein for its contribution to Zn tolerance in A. halleri.	Zinc	166-168	protodermal factor 1	Arabidopsis thaliana	29-33
24138881-7	2013	GM-CSF mediated Zn sequestration via MTs in vitro and in vivo in mice and in human macrophages.	Zinc	16-18	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
24138881-8	2013	These findings illuminate a GM-CSF-induced Zn-sequestration network that drives phagocyte antimicrobial effector function.	Zinc	43-45	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	28-34
24187545-5	2013	When expression of the Zn deficiency responsive marker gene ZIP4 was tested, the transgenic lines expressing AtHMA4 under an NcHMA4-1-LC promoter showed on average a 7-fold higher expression in the leaves, in comparison with the double hma2hma4 mutant, showing that this construct aggravated, rather than alleviated the severity of foliar Zn deficiency in the mutant, possible owing to expression in the leaf mesophyll.	Zinc	23-25	zinc transporter	Arabidopsis thaliana	60-64
23990470-9	2013	As a consequence, heparin-catalyzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn(2+) is present.	Zinc	130-132	coagulation factor X	Homo sapiens	50-59
23772702-0	2013	A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn2+.	Zinc	71-75	aquaporin 4	Homo sapiens	40-51
23772702-2	2013	Using a stopped-flow analysis, we showed that propofol (2,6-diisopropylphenol), a general anaesthetic drug, profoundly inhibited the osmotic water permeability of AQP4 proteoliposomes in the presence of Zn2+.	Zinc	203-207	aquaporin 4	Homo sapiens	163-167
24252376-13	2013	It is likely that any disturbance of Zn buffering by Zip14 and MT3 causes mitochondrial damage and cell death.	Zinc	37-39	metallothionein 3	Homo sapiens	63-66
23647428-5	2013	A docking study of some xanthates within the CA II active site showed that these compounds bind in a similar manner with the dithiocarbamates, coordinating monodentately to the Zn(II) ion from the enzyme active site.	Zinc	177-183	carbonic anhydrase 2	Homo sapiens	45-50
23463368-5	2013	Dietary Zn supplementation increased (P &lt; 0.05) ADG (mean effect size = 1.086, 95 % confidence intervals = 0.905-1.266, 26 studies, 72 comparisons), ADFI (mean effect size = 0.794, 95 % confidence intervals = 0.616-0.971, 25 studies, 71 comparisons), and G/F (mean effect size = 0.566, 95 % confidence intervals = 0.422-0.710, 24 studies, 70 comparisons).	Zinc	8-10	ADG	Sus scrofa	51-54
23712551-6	2013	We first examined the role of acidic voltage sensor residues that mediate divalent cation block of voltage activation in EAG superfamily channels because protons reduce the sensitivity of Kv12.1 to Zn(2+).	Zinc	198-200	potassium voltage-gated channel subfamily H member 1	Homo sapiens	121-124
23712551-6	2013	We first examined the role of acidic voltage sensor residues that mediate divalent cation block of voltage activation in EAG superfamily channels because protons reduce the sensitivity of Kv12.1 to Zn(2+).	Zinc	198-200	potassium voltage-gated channel subfamily H member 8	Homo sapiens	188-194
23589380-1	2013	The aim of this study was to investigate the effect of divalent metal ions (Ca, Mg(2+) , and Zn(2+) ) on the stability of oxytocin in aspartate buffer (pH 4.5) and to determine their interaction with the peptide in aqueous solution.	Zinc	93-95	oxytocin/neurophysin I prepropeptide	Homo sapiens	122-130
23589380-5	2013	As shown by isothermal titration calorimetry, Zn(2+) interacted with oxytocin in the presence of aspartate buffer, whereas Ca(2+) or Mg(2+) did not.	Zinc	46-52	oxytocin/neurophysin I prepropeptide	Homo sapiens	69-77
23589380-6	2013	In conclusion, the stability of oxytocin in the aspartate-buffered solution is strongly improved in the presence of Zn(2+) , and the stabilization effect is correlated with the ability of the divalent metal ions in aspartate buffer to interact with oxytocin.	Zinc	116-118	oxytocin/neurophysin I prepropeptide	Homo sapiens	32-40
23652332-8	2013	Zn(2+) binding to Abeta42 almost completely suppressed Abeta42 fibrillization, which could be significantly restored by SelP-H and SelM", as observed by thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM).	Zinc	0-5	selenoprotein M	Homo sapiens	131-136
23652332-9	2013	Interestingly, both SelP-H and SelM" inhibited Zn(2+)-Abeta42-induced neurotoxicity and the intracellular ROS production in living cells.	Zinc	47-53	selenoprotein M	Homo sapiens	31-36
23435881-7	2013	At 2 dpi, the relative percentages of CD4(+) T helper cells (P &lt; 0.01) and of CD2(+) T and NK cells (P &lt; 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group.	Zinc	208-210	CD4 molecule	Sus scrofa	38-41
23506888-1	2013	Two families of zinc (Zn(2 +)) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn(2+))-Iron(Fe(2+)) Permease).	Zinc	22-24	death associated protein kinase 3	Homo sapiens	131-134
23448290-3	2013	Some metal ions such as Ca, Mg, Ba and Zn are reported to modulate TRPA1 channel activity.	Zinc	39-41	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	67-72
23448290-8	2013	Heterologous expression of TRPA1 mutant channels that were less sensitive to Zn showed attenuation of Cd sensitivity.	Zinc	77-79	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	27-32
24244841-3	2013	The zinc catalysis is similar to the related zinc ion catalysis in metalloenzymes such as human carbonic anhydrase II and substantially enhances the O-nucleophilicity of N-acylated hydroxamines by forming the corresponding Zn chelates.	Zinc	223-225	carbonic anhydrase 2	Homo sapiens	96-117
24244866-7	2013	However, quantitative TRAP assay indicated the inhibiting effect of Zn on osteoclast differentiation.	Zinc	68-70	acid phosphatase 5, tartrate resistant	Mus musculus	22-26
23136062-4	2013	(68) Ga labeling of Zn(II)  complexes of TRAP and NOPO proceeds as efficient as labeling of neat NOTA; this applies also to the corresponding peptide conjugates of these chelators.	Zinc	20-26	TRAP	Homo sapiens	41-45
24194756-0	2013	Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 (SLC30A2) Gene in the Mother Highlighting the Importance of Zn (2+) for Normal Growth and Development.	Zinc	98-100	solute carrier family 30 member 2	Homo sapiens	105-112
24194756-4	2013	An exclusively breast-fed 6 months old infant suffering from Zn(2+) deficiency caused by an autosomal dominant negative G87R mutation in the Slc30a2 gene (encoding for the zinc transporter 2 (ZnT-2)) in the mother is reported.	Zinc	61-63	solute carrier family 30 member 2	Homo sapiens	141-148
23264639-5	2013	In yeast, AtZIP1 and AtZIP2 both complemented the Zn and Mn uptake mutants, suggesting that they both may transport Zn and/or Mn.	Zinc	50-52	ZRT/IRT-like protein 2	Arabidopsis thaliana	21-27
23264639-5	2013	In yeast, AtZIP1 and AtZIP2 both complemented the Zn and Mn uptake mutants, suggesting that they both may transport Zn and/or Mn.	Zinc	116-118	ZRT/IRT-like protein 2	Arabidopsis thaliana	21-27
23264639-8	2013	Functional studies with Arabidopsis AtZIP1 and AtZIP2 T-DNA knockout lines suggest that both transporters play a role in Mn (and possibly Zn) translocation from the root to the shoot.	Zinc	138-140	ZRT/IRT-like protein 2	Arabidopsis thaliana	47-53
23264639-10	2013	AtZIP2, on the other hand, may mediate Mn (and possibly Zn) uptake into root stellar cells, and thus also may contribute to Mn/Zn movement in the stele to the xylem parenchyma, for subsequent xylem loading and transport to the shoot.	Zinc	56-58	ZRT/IRT-like protein 2	Arabidopsis thaliana	0-6
23264639-10	2013	AtZIP2, on the other hand, may mediate Mn (and possibly Zn) uptake into root stellar cells, and thus also may contribute to Mn/Zn movement in the stele to the xylem parenchyma, for subsequent xylem loading and transport to the shoot.	Zinc	127-129	ZRT/IRT-like protein 2	Arabidopsis thaliana	0-6
23067206-1	2012	We describe photoinitiated electron transfer (ET) from a suite of Zn-substituted myoglobin (Mb) variants to cytochrome b(5) (b(5)).	Zinc	66-68	mitochondrially encoded cytochrome b	Homo sapiens	108-120
23061982-5	2012	The reactive substrate analogue 2(S)-amino-6-boronohexanoic acid (ABH) binds as a tetrahedral boronate anion to Mn(2+)(2), Co(2+)(2), Ni(2+)(2), and Zn(2+)(2) clusters in human arginase I, and it can be stabilized by a third inhibitory Zn(2+) ion coordinated by H141.	Zinc	149-155	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	66-69
23061982-5	2012	The reactive substrate analogue 2(S)-amino-6-boronohexanoic acid (ABH) binds as a tetrahedral boronate anion to Mn(2+)(2), Co(2+)(2), Ni(2+)(2), and Zn(2+)(2) clusters in human arginase I, and it can be stabilized by a third inhibitory Zn(2+) ion coordinated by H141.	Zinc	236-242	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	66-69
22957890-1	2012	Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM).	Zinc	91-97	C-C motif chemokine receptor 5	Homo sapiens	48-52
22732570-5	2012	RNA binding required the presence of Zn(2+) and conserved cysteines in the C-terminal domain, suggesting that Zar2 contains a zinc finger.	Zinc	37-39	ZAR1-like protein S homeolog	Xenopus laevis	110-114
22893522-8	2012	The investigation of the Zn-ring interactions is extended to the delocalization index, the source function, and a new type of electron-density-based surfaces, which we introduce here (ASF = aspherical stockholder fragments).	Zinc	25-27	arylsulfatase F	Homo sapiens	184-187
22689922-12	2012	In regressing tongue SCCs from Zn-supplemented rats, miR-31 and miR-21 expression was concomitantly reduced, establishing their responsiveness to Zn therapy.	Zinc	31-33	microRNA 31	Rattus norvegicus	53-59
22689922-12	2012	In regressing tongue SCCs from Zn-supplemented rats, miR-31 and miR-21 expression was concomitantly reduced, establishing their responsiveness to Zn therapy.	Zinc	31-33	microRNA 21	Rattus norvegicus	64-70
22689922-12	2012	In regressing tongue SCCs from Zn-supplemented rats, miR-31 and miR-21 expression was concomitantly reduced, establishing their responsiveness to Zn therapy.	Zinc	146-148	microRNA 31	Rattus norvegicus	53-59
22689922-12	2012	In regressing tongue SCCs from Zn-supplemented rats, miR-31 and miR-21 expression was concomitantly reduced, establishing their responsiveness to Zn therapy.	Zinc	146-148	microRNA 21	Rattus norvegicus	64-70
22636781-7	2012	When expressed in Escherichia coli, however, the putative Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increased by the addition of Zn(2+) and Cd(2+) as well as by Cu(+).	Zinc	58-60	ATPase	Escherichia coli	72-78
22636781-7	2012	When expressed in Escherichia coli, however, the putative Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increased by the addition of Zn(2+) and Cd(2+) as well as by Cu(+).	Zinc	58-60	ATPase	Escherichia coli	130-136
22636781-7	2012	When expressed in Escherichia coli, however, the putative Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increased by the addition of Zn(2+) and Cd(2+) as well as by Cu(+).	Zinc	179-181	ATPase	Escherichia coli	72-78
22636781-7	2012	When expressed in Escherichia coli, however, the putative Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increased by the addition of Zn(2+) and Cd(2+) as well as by Cu(+).	Zinc	179-181	ATPase	Escherichia coli	130-136
22411188-2	2012	Adapting findings from the literature of Zn(II) ion sensors, we previously reported chelating sulfonamide inhibitors of MMP-2, some of which showed excellent selectivity over other gelatinases (MMP-9).	Zinc	41-47	matrix metallopeptidase 9	Homo sapiens	194-199
22102510-7	2012	We found that Ca(2+) or Zn(2+) entry via the transient receptor potential melastatin 7 (TRPM7) channel was attenuated by the presence of FAD-associated PS1 mutants, such as DeltaE9 and L286V.	Zinc	24-26	transient receptor potential cation channel subfamily M member 7	Homo sapiens	45-86
22102510-7	2012	We found that Ca(2+) or Zn(2+) entry via the transient receptor potential melastatin 7 (TRPM7) channel was attenuated by the presence of FAD-associated PS1 mutants, such as DeltaE9 and L286V.	Zinc	24-26	transient receptor potential cation channel subfamily M member 7	Homo sapiens	88-93
22450164-5	2012	The nuclease activity of the His-AtCaN2 fusion protein was highest at 37 C, required a neutral or weakly-alkaline environment, and was stimulated by Ca(2+) and Mg(2+), but inhibited by Zn(2+) and high concentration of Mn(2+).	Zinc	185-187	Ca(2+)-dependent nuclease family protein	Arabidopsis thaliana	33-39
22362075-1	2012	Zn-doped SnO(2) nanorods have been prepared by a simple hydrothermal method on a large scale.	Zinc	0-2	strawberry notch homolog 2	Homo sapiens	9-12
22362075-4	2012	The photocatalytic properties of the synthesized Zn-doped SnO(2) were investigated by decomposing acid fuchsine, showing much higher photocatalytic activity than pure SnO(2) nanorods and bulk SnO(2) powders.	Zinc	49-51	strawberry notch homolog 2	Homo sapiens	58-61
22362075-4	2012	The photocatalytic properties of the synthesized Zn-doped SnO(2) were investigated by decomposing acid fuchsine, showing much higher photocatalytic activity than pure SnO(2) nanorods and bulk SnO(2) powders.	Zinc	49-51	strawberry notch homolog 2	Homo sapiens	167-170
22362075-4	2012	The photocatalytic properties of the synthesized Zn-doped SnO(2) were investigated by decomposing acid fuchsine, showing much higher photocatalytic activity than pure SnO(2) nanorods and bulk SnO(2) powders.	Zinc	49-51	strawberry notch homolog 2	Homo sapiens	167-170
22356117-13	2012	The chelation-enhanced-fluorescence (CHEF) effect induced by some metal ions is presented, and the trend of the CHEF effect, which is Ca(II) &gt; Zn(II) &gt; Cd(II) ~ La(III) &gt; Hg(II), is discussed in terms of factors that control the CHEF effect, such as the heavy-atom effect.	Zinc	146-148	carbonic anhydrase 2	Homo sapiens	134-140
22463568-0	2012	Spin-flip limited exciton dephasing in CdSe/ZnS colloidal quantum dots.	Zinc	44-47	spindlin 1	Homo sapiens	0-4
22177543-4	2012	Glucose oxidase (GOX) and alcohol oxidase (AOX) were chosen as the model oxidase enzymes, conjugated to carboxyl-terminated CdSe/ZnS QDs, and entrapped within the hydrogel microstructures, which resulted in a fluorescent hydrogel microarray that was responsive to glucose or alcohol.	Zinc	129-132	hydroxyacid oxidase 1	Homo sapiens	0-15
22177543-4	2012	Glucose oxidase (GOX) and alcohol oxidase (AOX) were chosen as the model oxidase enzymes, conjugated to carboxyl-terminated CdSe/ZnS QDs, and entrapped within the hydrogel microstructures, which resulted in a fluorescent hydrogel microarray that was responsive to glucose or alcohol.	Zinc	129-132	hydroxyacid oxidase 1	Homo sapiens	17-20
22177543-4	2012	Glucose oxidase (GOX) and alcohol oxidase (AOX) were chosen as the model oxidase enzymes, conjugated to carboxyl-terminated CdSe/ZnS QDs, and entrapped within the hydrogel microstructures, which resulted in a fluorescent hydrogel microarray that was responsive to glucose or alcohol.	Zinc	129-132	acyl-CoA oxidase 1	Homo sapiens	26-41
22177543-4	2012	Glucose oxidase (GOX) and alcohol oxidase (AOX) were chosen as the model oxidase enzymes, conjugated to carboxyl-terminated CdSe/ZnS QDs, and entrapped within the hydrogel microstructures, which resulted in a fluorescent hydrogel microarray that was responsive to glucose or alcohol.	Zinc	129-132	acyl-CoA oxidase 1	Homo sapiens	43-46
22065580-7	2012	The 3.0-A-resolution crystal structure of a construct comprising the RRM and AlkB domains shows disordered loops flanking the active site in the AlkB domain and a unique structural Zn(II)-binding site at its C terminus.	Zinc	181-187	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	77-81
22830351-7	2012	Zn(2+) binds most strongly to CMC 2.24 compared to CMC 2.5 and curcumin, with dissociation constants of 0.77+-0.02, 1.88+-0.07, and 1.39+-0.09 mM.	Zinc	0-2	C-X9-C motif containing 2	Homo sapiens	30-35
22830351-7	2012	Zn(2+) binds most strongly to CMC 2.24 compared to CMC 2.5 and curcumin, with dissociation constants of 0.77+-0.02, 1.88+-0.07, and 1.39+-0.09 mM.	Zinc	0-2	C-X9-C motif containing 2	Homo sapiens	51-56
22830351-8	2012	The increased acidity and Zn(2+) and BSA affinities of CMC 2.24 correlate with its greater biological activity.	Zinc	26-28	C-X9-C motif containing 2	Homo sapiens	55-60
22120741-9	2011	The TTR L55P-Zn(2+) structure offers the first molecular insights into the role of Zn(2+) as a mediator of cross-beta-type structure in TTR amyloidosis and the relevance of a Zn(2+)-dependent pathway leading to the production of early amyloidogenic intermediates is discussed.	Zinc	13-15	transthyretin	Homo sapiens	4-7
22120741-9	2011	The TTR L55P-Zn(2+) structure offers the first molecular insights into the role of Zn(2+) as a mediator of cross-beta-type structure in TTR amyloidosis and the relevance of a Zn(2+)-dependent pathway leading to the production of early amyloidogenic intermediates is discussed.	Zinc	13-15	transthyretin	Homo sapiens	136-139
22120741-9	2011	The TTR L55P-Zn(2+) structure offers the first molecular insights into the role of Zn(2+) as a mediator of cross-beta-type structure in TTR amyloidosis and the relevance of a Zn(2+)-dependent pathway leading to the production of early amyloidogenic intermediates is discussed.	Zinc	83-85	transthyretin	Homo sapiens	4-7
22120741-9	2011	The TTR L55P-Zn(2+) structure offers the first molecular insights into the role of Zn(2+) as a mediator of cross-beta-type structure in TTR amyloidosis and the relevance of a Zn(2+)-dependent pathway leading to the production of early amyloidogenic intermediates is discussed.	Zinc	83-85	transthyretin	Homo sapiens	136-139
22131323-3	2011	Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel.	Zinc	17-19	immunoglobulin lambda variable 7-46	Homo sapiens	104-112
21998043-9	2011	Interestingly, the Zn(II) complex, which carries an overall +4 charge, revealed marginally higher specificity and reduced toxicity in vitro compared to the free ligand, albeit with reduced affinity for CXCR4 (IC(50) =1.8-5 muM).	Zinc	19-25	chemokine (C-X-C motif) receptor 4	Mus musculus	202-207
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Zinc	305-307	interleukin 6	Equus caballus	149-153
21729692-6	2011	In addition, we demonstrate that the activity of MIPS from Arabidopsis thaliana is moderately enhanced by the addition Mg(2+) and is not enhanced by other divalent metal ions (Zn(2+) and Mn(2+)), consistent with what has been observed for other eukaryotic MIPS enzymes.	Zinc	176-178	myo-inositol-1-phosphate synthase 1	Arabidopsis thaliana	49-53
21936876-11	2011	Zn(2+)  ions, which inhibit TRESK and TASK-3 K2P channels, decreased NT-induced current.	Zinc	0-2	neurotensin	Rattus norvegicus	69-71
21806983-4	2011	The administration of Zn decreased the activities of bone tartrate-resistant acid phosphatase (TRAP) and cathepsin K, without affecting the serum osteocalcin level.	Zinc	22-24	acid phosphatase 5, tartrate resistant	Rattus norvegicus	58-93
21806983-4	2011	The administration of Zn decreased the activities of bone tartrate-resistant acid phosphatase (TRAP) and cathepsin K, without affecting the serum osteocalcin level.	Zinc	22-24	acid phosphatase 5, tartrate resistant	Rattus norvegicus	95-99
21777051-6	2011	The results obtained suggest that Zn-induced augmentation of total SOD, SOD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in Zn-induced oxidative stress leading to dopaminergic neurodegeneration.	Zinc	34-36	superoxide dismutase 2	Rattus norvegicus	78-82
21777051-6	2011	The results obtained suggest that Zn-induced augmentation of total SOD, SOD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in Zn-induced oxidative stress leading to dopaminergic neurodegeneration.	Zinc	34-36	heme oxygenase 1	Rattus norvegicus	87-91
21823579-9	2011	Furthermore, DUT-30(Zn) exhibits a hydrogen storage capacity of 1.12 wt % at 1 bar, a CO(2) uptake of 200 cm(3) g(-1) at -78  C and 0.9 bar, and a n-butane uptake of 3.0 mmol g(-1) at 20  C. The N(2) adsorption process was monitored in situ via X-ray powder diffraction using synchrotron radiation.	Zinc	20-22	deoxyuridine triphosphatase	Homo sapiens	13-16
21947926-0	2011	Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.	Zinc	0-2	ubiquitin protein ligase E3A	Homo sapiens	57-62
21947926-3	2011	The structure of this domain  adopts a novel Zn-binding  fold we called AZUL (Amino-terminal Zn-finger of Ube3a Ligase).	Zinc	45-47	ubiquitin protein ligase E3A	Homo sapiens	106-111
21665525-5	2011	The responsive mechanism of the two probes to Zn2+ were involved both the CN isomerization and ICT, which were clarified by NBO charge analysis and the HOMO-LUMO energy gap calculation by using B3LYP/6-31G density functional theory.	Zinc	46-50	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	196-199
21668449-4	2011	Zn(2+)-binding of SV31 in viable cells was verified following heterologous transfection of pheochromocytoma cells 12 (PC12) with recombinant red fluorescent SV31 (SV31-RFP) and the fluorescent zinc indicator FluoZin-3.	Zinc	0-6	transmembrane protein 163	Rattus norvegicus	18-22
21668449-4	2011	Zn(2+)-binding of SV31 in viable cells was verified following heterologous transfection of pheochromocytoma cells 12 (PC12) with recombinant red fluorescent SV31 (SV31-RFP) and the fluorescent zinc indicator FluoZin-3.	Zinc	0-6	transmembrane protein 163	Rattus norvegicus	157-161
21668449-4	2011	Zn(2+)-binding of SV31 in viable cells was verified following heterologous transfection of pheochromocytoma cells 12 (PC12) with recombinant red fluorescent SV31 (SV31-RFP) and the fluorescent zinc indicator FluoZin-3.	Zinc	0-6	transmembrane protein 163	Rattus norvegicus	163-171
21697297-9	2011	Prenatal Zn exposure suppressed CTB- (P = 0.05) and BSA-specific proliferation response of Peyer"s Patch lymphocytes (P = 0.07).	Zinc	9-11	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	32-35
21507889-4	2011	Pre-incubation of Int with ethylenediaminetetraacetic acid (EDTA) was detrimental for both recombination activity and DNA binding affinities but full activity could be restored by adding back Zn(2+).	Zinc	192-194	inturned planar cell polarity protein	Homo sapiens	18-21
21590363-2	2011	In the presence of 200 muM extracellular Cd(2+) to abolish voltage-dependent Ca(2+) currents, and 100 mM extracellular Na(+), 1 mM Zn(2+) inhibited the transient Na(+) current, I (NaT), only to a modest degree (~17% on average).	Zinc	131-133	bromodomain containing 2	Homo sapiens	180-183
21590363-4	2011	Zn(2+) also proved to modify I (NaT) voltage-dependent and kinetic properties in multiple ways.	Zinc	0-2	bromodomain containing 2	Homo sapiens	32-35
21590363-5	2011	Zn(2+) (1 mM) shifted the voltage dependence of I (NaT) activation and that of I (NaT) onset speed in the positive direction by ~5 mV.	Zinc	0-2	bromodomain containing 2	Homo sapiens	51-54
21590363-5	2011	Zn(2+) (1 mM) shifted the voltage dependence of I (NaT) activation and that of I (NaT) onset speed in the positive direction by ~5 mV.	Zinc	0-2	bromodomain containing 2	Homo sapiens	82-85
21590363-6	2011	The voltage dependence of I (NaT) steady-state inactivation and that of I (NaT) inactivation kinetics were markedly less affected by Zn(2+).	Zinc	133-135	bromodomain containing 2	Homo sapiens	29-32
21590363-6	2011	The voltage dependence of I (NaT) steady-state inactivation and that of I (NaT) inactivation kinetics were markedly less affected by Zn(2+).	Zinc	133-135	bromodomain containing 2	Homo sapiens	75-78
21590363-8	2011	In addition, the kinetics of I (NaT) recovery from inactivation were significantly slowed by Zn(2+).	Zinc	93-95	bromodomain containing 2	Homo sapiens	32-35
21590363-9	2011	Zn(2+) inhibition of I (NaT) showed no signs of voltage dependence over the explored membrane-voltage window, indicating that the above effects cannot be explained by voltage dependence of Zn(2+)-induced channel-pore block.	Zinc	0-2	bromodomain containing 2	Homo sapiens	24-27
21289295-5	2011	We found that attenuation of ZnT2 expression significantly reduced mitochondrial Zn uptake and total mitochondrial Zn pools.	Zinc	81-83	solute carrier family 30 member 2	Homo sapiens	29-33
21289295-6	2011	Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria.	Zinc	26-28	solute carrier family 30 member 2	Homo sapiens	182-186
21289295-6	2011	Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria.	Zinc	123-125	solute carrier family 30 member 2	Homo sapiens	26-30
21289295-6	2011	Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria.	Zinc	123-125	solute carrier family 30 member 2	Homo sapiens	182-186
21289295-6	2011	Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria.	Zinc	123-125	solute carrier family 30 member 2	Homo sapiens	26-30
21289295-6	2011	Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria.	Zinc	123-125	solute carrier family 30 member 2	Homo sapiens	182-186
21289295-8	2011	More importantly, the expansion of mitochondrial Zn pools by ZnT2 overexpression significantly reduced ATP biogenesis and mitochondrial oxidation concurrent with increased apoptosis, suggesting a functional role for ZnT2-mediated Zn import into mitochondria.	Zinc	49-51	solute carrier family 30 member 2	Homo sapiens	61-65
21289295-8	2011	More importantly, the expansion of mitochondrial Zn pools by ZnT2 overexpression significantly reduced ATP biogenesis and mitochondrial oxidation concurrent with increased apoptosis, suggesting a functional role for ZnT2-mediated Zn import into mitochondria.	Zinc	49-51	solute carrier family 30 member 2	Homo sapiens	216-220
21289295-8	2011	More importantly, the expansion of mitochondrial Zn pools by ZnT2 overexpression significantly reduced ATP biogenesis and mitochondrial oxidation concurrent with increased apoptosis, suggesting a functional role for ZnT2-mediated Zn import into mitochondria.	Zinc	61-63	solute carrier family 30 member 2	Homo sapiens	216-220
21525261-6	2011	In a culture experiment using isolated mesenteric leukocytes, TNFalpha production was higher (P &lt; 0.05) and TNF receptor type I (TNFR1) expression was detected in culture medium containing 20 and 30 mumol/L of Zn compared with culture medium lacking Zn supplementation.	Zinc	213-215	TNF receptor superfamily member 1A	Rattus norvegicus	132-137
21377473-8	2011	We propose a model of the tetrahedral coordination of a Zn(2+) by (Cys)(3)His residues that is compatible with SS2 formation in S100A3.	Zinc	56-58	butyrophilin like 2	Homo sapiens	111-114
21353385-4	2011	The Zn transporter ZnT2 sequesters Zn into intracellular vesicles and thus can protect cells from Zn cytotoxicity.	Zinc	4-6	solute carrier family 30 member 2	Homo sapiens	19-23
21353385-8	2011	Suppression of ZnT2 significantly increased cytoplasmic Zn pools (1.6-fold) as assessed with a Zn-responsive reporter assay containing four metal response elements (4X-MRE) fused to luciferase.	Zinc	56-58	solute carrier family 30 member 2	Homo sapiens	15-19
21353385-12	2011	Our data indicate that ZnT2 over-expression protects malignant MT-null breast tumor cells from Zn hyper-accumulation by sequestering Zn into intracellular vesicles.	Zinc	95-97	solute carrier family 30 member 2	Homo sapiens	23-27
21417258-4	2011	Here we show that binding of human gammaD-crystallin (HGD, a natural substrate) to human alphaA-crystallin (HAA) is inversely related to the binding of Cu2+/Zn2+ ions: The higher the amount of bound HGD, the lower the amount of bound metal ions.	Zinc	157-161	homogentisate 1,2-dioxygenase	Homo sapiens	54-57
21417258-4	2011	Here we show that binding of human gammaD-crystallin (HGD, a natural substrate) to human alphaA-crystallin (HAA) is inversely related to the binding of Cu2+/Zn2+ ions: The higher the amount of bound HGD, the lower the amount of bound metal ions.	Zinc	157-161	homogentisate 1,2-dioxygenase	Homo sapiens	199-202
21237246-3	2011	Ap-B is a member of the M1 family of Zn(2+)-metallopeptidases that are characterized by two highly conserved motives, GXMEN (potential substrate binding site) and HEXXHX(18)E (Zn(2+)-binding site).	Zinc	37-43	arginyl aminopeptidase	Homo sapiens	0-4
21237246-7	2011	The S(328)A mutant mimics the sequence of bovine Ap-B Zn(2+)-binding site, which differs from those of other mammalian Ap-B.	Zinc	54-60	arginyl aminopeptidase	Homo sapiens	119-123
21847988-7	2011	AtCAX3 is the mainly Ca2+/H+ transporter in response to salt stress; AtCAX2 and AtCAX4 participate in transportation and detoxicification of heavy metal ions (Cd2+, Zn2+, and Mn2+) in cells under heavy metal stress, and impact root/shoot Cd partitioning in plant.	Zinc	165-169	cation exchanger 4	Arabidopsis thaliana	80-86
21268159-8	2011	Zinc(II) acetate gives, at low metal-to-protein molar ratios (8:1), crystals containing one metal ion per three molecules of protein, Zn-hUb(3) (already reported in previous work), whereas at high metal-to-protein ratios (70:1) gives crystals containing three Zn(II) ions per protein molecule, Zn(3)-hUb.	Zinc	134-136	ELAV like RNA binding protein 2	Homo sapiens	137-140
21268159-11	2011	Present and previous results of cocrystallization experiments performed with Zn(II) and other Group 12 metal ions allow a comprehensive understanding of the metal-ion binding properties of hUb with His68 as the main anchoring site, followed by Met1 and carboxylic groups of Glu16, Glu18, Glu64, Asp21, and Asp32, to be reached.	Zinc	77-83	ELAV like RNA binding protein 2	Homo sapiens	189-192
21268159-11	2011	Present and previous results of cocrystallization experiments performed with Zn(II) and other Group 12 metal ions allow a comprehensive understanding of the metal-ion binding properties of hUb with His68 as the main anchoring site, followed by Met1 and carboxylic groups of Glu16, Glu18, Glu64, Asp21, and Asp32, to be reached.	Zinc	77-83	beta-secretase 2	Homo sapiens	295-300
21049302-10	2011	Analogous relations were found for Cu in the DG and Zn in sector 3 of Ammon"s horn (CA3) and the DG.	Zinc	52-54	carbonic anhydrase 3	Rattus norvegicus	84-87
29861700-0	2011	Minerals (Zn, Fe, Ca and Mg) and Antinutrient (Phytic Acid) Constituents in Common Bean.	Zinc	10-12	brain expressed associated with NEDD4 1	Homo sapiens	83-87
21146870-6	2011	Live cell imaging experiments with Fura-2 and NewPort Green DCF showed that overexpression of human TRPV6 increased the permeability for Ca(2+), Ba(2+), Sr(2+), Mn(2+), Zn(2+), Cd(2+), and interestingly also for La(3+) and Gd(3+).	Zinc	169-171	transient receptor potential cation channel subfamily V member 6	Homo sapiens	100-105
21790058-6	2011	Zn supplementation, at low level, restored and enhanced the functional activity of these enzymes (SOD, CAT, APX and GR) as compared to Cd-alone-treated plants.	Zinc	0-2	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	108-111
21138269-14	2010	Crystal structures of these double-headed aminopyridine inhibitors in complexes with nNOS show unexpected and significant protein and heme conformational changes induced by inhibitor binding that result in removal of the tetrahydrobiopterin (H(4)B) cofactor and creation of a new Zn(2+) site.	Zinc	280-286	H4 clustered histone 4	Homo sapiens	242-247
21138269-15	2010	These changes are due to binding of a second inhibitor molecule that results in the displacement of H(4)B and the placement of the inhibitor pyridine group in position to serve as a Zn(2+) ligand together with Asp, His, and a chloride ion.	Zinc	182-184	H4 clustered histone 4	Homo sapiens	100-105
20815357-2	2010	It is a 40 kDa monomeric TIM-barrel protein containing a tightly bound Zn(2+), which is required for activity.	Zinc	71-73	translocation induced circling mutation	Mus musculus	25-28
21131558-3	2010	The Zn binding SBP domain of CRR1 binds copper ions in vitro.	Zinc	4-6	uncharacterized protein	Chlamydomonas reinhardtii	29-33
21131558-9	2010	Strains carrying the crr1-DeltaCys allele upregulate ZRT genes and hyperaccumulate Zn(II), suggesting that the effect of nickel ions may be revealing a role for the C-terminal domain of CRR1 in zinc homeostasis in Chlamydomonas.	Zinc	83-89	uncharacterized protein	Chlamydomonas reinhardtii	21-25
20659897-0	2010	Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.	Zinc	6-10	transthyretin	Homo sapiens	34-47
20659897-2	2010	Zn(2+) enhances TTR aggregation in vitro, and is a component of ex vivo TTR amyloid fibrils.	Zinc	0-6	transthyretin	Homo sapiens	16-19
20659897-2	2010	Zn(2+) enhances TTR aggregation in vitro, and is a component of ex vivo TTR amyloid fibrils.	Zinc	0-6	transthyretin	Homo sapiens	72-75
20659897-3	2010	We report the first crystal structure of human TTR in complex with Zn(2+) at pH 4.6-7.5.	Zinc	67-69	transthyretin	Homo sapiens	47-50
20659897-5	2010	Zn(2+) binding perturbs loop E-alpha-helix-loop F, the region involved in holo-retinol-binding protein (holo-RBP) recognition, mainly at acidic pH; TTR affinity for holo-RBP decreases ~5-fold in the presence of Zn(2+).	Zinc	211-213	transthyretin	Homo sapiens	148-151
20659897-6	2010	Interestingly, this same region is disrupted in the crystal structure of the amyloidogenic intermediate of TTR formed at acidic pH in the absence of Zn(2+).	Zinc	149-151	transthyretin	Homo sapiens	107-110
20659897-8	2010	While stability of the monomer of TTR decreases in the presence of Zn(2+), which is consistent with the tertiary structural perturbation provoked by Zn(2+) binding, tetramer stability is only marginally affected by Zn(2+).	Zinc	67-69	transthyretin	Homo sapiens	34-37
20659897-8	2010	While stability of the monomer of TTR decreases in the presence of Zn(2+), which is consistent with the tertiary structural perturbation provoked by Zn(2+) binding, tetramer stability is only marginally affected by Zn(2+).	Zinc	149-151	transthyretin	Homo sapiens	34-37
20659897-8	2010	While stability of the monomer of TTR decreases in the presence of Zn(2+), which is consistent with the tertiary structural perturbation provoked by Zn(2+) binding, tetramer stability is only marginally affected by Zn(2+).	Zinc	149-151	transthyretin	Homo sapiens	34-37
20659897-9	2010	These data highlight structural and functional roles of Zn(2+) in TTR-related amyloidoses, as well as in holo-RBP recognition and vitamin A homeostasis.	Zinc	56-58	transthyretin	Homo sapiens	66-69
20647347-2	2010	Here, we show that Arabidopsis thaliana PCR2 is essential for Zn redistribution and Zn detoxification.	Zinc	62-64	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	40-44
20647347-2	2010	Here, we show that Arabidopsis thaliana PCR2 is essential for Zn redistribution and Zn detoxification.	Zinc	84-86	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	40-44
20647347-3	2010	The pcr2 loss-of-function mutant was compromised in growth, both in Zn-excessive and -deficient conditions.	Zinc	68-70	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	4-8
20647347-4	2010	The roots of pcr2 accumulated more Zn than did control plants, whereas the roots of plants overexpressing PCR2 contained less Zn, indicating that PCR2 removes Zn from the roots.	Zinc	35-37	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	13-17
20647347-4	2010	The roots of pcr2 accumulated more Zn than did control plants, whereas the roots of plants overexpressing PCR2 contained less Zn, indicating that PCR2 removes Zn from the roots.	Zinc	126-128	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	106-110
20647347-4	2010	The roots of pcr2 accumulated more Zn than did control plants, whereas the roots of plants overexpressing PCR2 contained less Zn, indicating that PCR2 removes Zn from the roots.	Zinc	126-128	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	106-110
20647347-5	2010	Consistent with a role for PCR2 as a Zn-efflux transporter, PCR2 reduced the intracellular concentration of Zn when expressed in yeast cells.	Zinc	37-39	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	27-31
20647347-5	2010	Consistent with a role for PCR2 as a Zn-efflux transporter, PCR2 reduced the intracellular concentration of Zn when expressed in yeast cells.	Zinc	37-39	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	60-64
20647347-7	2010	Zn accumulated in the epidermis of the roots of pcr2 grown under Zn-limiting conditions, whereas it was found in the stele of wild-type roots.	Zinc	0-2	PLANT CADMIUM RESISTANCE 2	Arabidopsis thaliana	48-52
20481436-5	2010	The hydrolytic activity of ALP is followed by the application of phosphotyrosine (4)-modified CdSe/ZnS QDs in the presence of tyrosinase as a secondary reporter biocatalyst.	Zinc	99-102	tyrosinase	Homo sapiens	126-136
20479680-8	2010	In F cells, zinc-regulated transporter (ZRT)/iron-regulated transporter (IRT)-like protein (Zip)4 expression was undetectable; Zn (50 micromol/L) increased levels of Zn transporter (ZnT)1, ZnT2, and metallothionein-1 mRNA and ZnT1 protein.	Zinc	127-129	solute carrier family 30 member 2	Homo sapiens	189-193
20479680-10	2010	In U cells, Zn exposure increased Zip4 protein level, but not membrane-associated abundance.	Zinc	12-14	solute carrier family 39 member 4	Homo sapiens	34-38
20479680-11	2010	However, in D cells, Zn exposure decreased both the Zip4 protein level and membrane-associated abundance.	Zinc	21-23	solute carrier family 39 member 4	Homo sapiens	52-56
20392050-0	2010	Lower rim 1,3-diderivative of calix[4]arene-appended salicylidene imine (H(2)L): experimental and computational studies of the selective recognition of H(2)L toward Zn(2+) and sensing phosphate and amino acid by [ZnL].	Zinc	165-167	regulating synaptic membrane exocytosis 1	Homo sapiens	6-11
20380468-4	2010	The most representative structures derived from the Abeta40-IDE and Abeta42-IDE simulations accurately reproduced the locations of the active site Zn(2+) metal and small fragments of the substrates and their interactions with the enzyme from the X-ray structures.	Zinc	147-149	insulin degrading enzyme	Homo sapiens	60-63
20392164-12	2010	Cathepsin B was 50% inhibited by 1 muM Zn(2+), and is reportedly inhibited by gold agents.	Zinc	39-41	cathepsin B	Homo sapiens	0-11
20129672-9	2010	It is proposed that the inhibitory effect of the ions (Co(2+), Mn(2+), and Zn(2+)) or selenite on hAS3MT activity might be via the interactions of them with free Cys residues in hAS3MT to form inactive protein adducts.	Zinc	75-81	arsenite methyltransferase	Homo sapiens	98-104
20060848-7	2010	Compared to PMKC exposed to 5 microM Cd alone, inclusion of 5 microM Zn restored SGLT1 and 2 mRNA levels by 15% and 30%, respectively.	Zinc	69-71	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	81-92
20060848-10	2010	Co-treatment with Cd and Zn showed that added Zn significantly restored rhSp1 binding to the SGLT1 and SGLT2.	Zinc	25-27	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	93-98
20060848-10	2010	Co-treatment with Cd and Zn showed that added Zn significantly restored rhSp1 binding to the SGLT1 and SGLT2.	Zinc	46-48	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	93-98
20060848-10	2010	Co-treatment with Cd and Zn showed that added Zn significantly restored rhSp1 binding to the SGLT1 and SGLT2.	Zinc	46-48	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	103-108
20048154-3	2010	Here we show strong evidence suggesting that TRPM7 channels also play an important role in cellular Zn(2+) homeostasis and in Zn(2+)-mediated neuronal injury.	Zinc	100-102	transient receptor potential cation channel subfamily M member 7	Homo sapiens	45-50
20048154-3	2010	Here we show strong evidence suggesting that TRPM7 channels also play an important role in cellular Zn(2+) homeostasis and in Zn(2+)-mediated neuronal injury.	Zinc	100-103	transient receptor potential cation channel subfamily M member 7	Homo sapiens	45-50
20048154-5	2010	The Zn(2+)-mediated neurotoxicity was inhibited by nonspecific TRPM7 blockers Gd(3+) or 2-aminoethoxydiphenyl borate, and by knockdown of TRPM7 channels with small interfering RNA.	Zinc	4-10	transient receptor potential cation channel subfamily M member 7	Homo sapiens	63-68
20048154-5	2010	The Zn(2+)-mediated neurotoxicity was inhibited by nonspecific TRPM7 blockers Gd(3+) or 2-aminoethoxydiphenyl borate, and by knockdown of TRPM7 channels with small interfering RNA.	Zinc	4-10	transient receptor potential cation channel subfamily M member 7	Homo sapiens	138-143
20048154-6	2010	In addition, Zn(2+)-mediated neuronal injury under oxygen-glucose deprivation conditions was also diminished by silencing TRPM7.	Zinc	13-19	transient receptor potential cation channel subfamily M member 7	Homo sapiens	122-127
20048154-7	2010	Furthermore, we show that overexpression of TRPM7 channels in HEK293 cells increased intracellular Zn(2+) accumulation and Zn(2+)-induced cell injury, while silencing TRPM7 by small interfering RNA attenuated the Zn(2+)-mediated cell toxicity.	Zinc	99-101	transient receptor potential cation channel subfamily M member 7	Homo sapiens	44-49
20048154-7	2010	Furthermore, we show that overexpression of TRPM7 channels in HEK293 cells increased intracellular Zn(2+) accumulation and Zn(2+)-induced cell injury, while silencing TRPM7 by small interfering RNA attenuated the Zn(2+)-mediated cell toxicity.	Zinc	123-125	transient receptor potential cation channel subfamily M member 7	Homo sapiens	44-49
20048154-7	2010	Furthermore, we show that overexpression of TRPM7 channels in HEK293 cells increased intracellular Zn(2+) accumulation and Zn(2+)-induced cell injury, while silencing TRPM7 by small interfering RNA attenuated the Zn(2+)-mediated cell toxicity.	Zinc	123-125	transient receptor potential cation channel subfamily M member 7	Homo sapiens	44-49
20048154-8	2010	Thus, TRPM7 channels may represent a novel target for neurological disorders where Zn(2+) toxicity plays an important role.	Zinc	83-89	transient receptor potential cation channel subfamily M member 7	Homo sapiens	6-11
20163680-5	2010	We here show that fibromodulin, fibronectin and laminin bind to myostatin in the presence of Zn(2+) with a dissociation constant (K(D)) of 10(-10) approximately 10(-8) mol/L.	Zinc	93-95	fibromodulin	Homo sapiens	18-30
19914683-4	2010	As far as PM1 chemical composition is concerned, the mean values of the trace element concentrations decreased in the following order: Ca&gt;Fe&gt;Al&gt;Na&gt;K&gt;Cr&gt;Mg&gt;Pb&gt;Ni approximately Ti approximately Zn&gt;Cd approximately Cu&gt;Mn.	Zinc	216-218	transmembrane protein 11	Homo sapiens	10-13
19911785-0	2009	Eight-coordinate Zn(II), Cd(II), and Pb(II) complexes based on a 1,7-diaza-12-crown-4 platform endowed with a remarkable selectivity over Ca(II).	Zinc	17-23	carbonic anhydrase 2	Homo sapiens	138-144
19682970-4	2009	By this assay, we found that nicotinamide, Cu(2+), and Zn(2+) antagonize the activity of SIRT1.	Zinc	55-61	sirtuin 1	Homo sapiens	89-94
19841782-0	2009	Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).	Zinc	78-80	lysine demethylase 4A	Homo sapiens	45-51
19841782-1	2009	JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone demethylase, is inhibited by disruption of its Zn-binding site by Zn-ejecting compounds including disulfiram and ebselen; this observation may enable the development of inhibitors selective for this subfamily of 2OG dependent oxygenases that do not rely on binding to the highly-conserved Fe(ii)-containing active site.	Zinc	115-117	lysine demethylase 4A	Homo sapiens	0-6
19841782-1	2009	JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone demethylase, is inhibited by disruption of its Zn-binding site by Zn-ejecting compounds including disulfiram and ebselen; this observation may enable the development of inhibitors selective for this subfamily of 2OG dependent oxygenases that do not rely on binding to the highly-conserved Fe(ii)-containing active site.	Zinc	134-136	lysine demethylase 4A	Homo sapiens	0-6
19679159-0	2009	Plasma fatty acid levels may regulate the Zn(2+)-dependent activities of histidine-rich glycoprotein.	Zinc	42-48	histidine rich glycoprotein	Homo sapiens	73-100
19679159-3	2009	A large body of evidence suggests that Zn(2+) ions stimulate HRG-complex formation; however, under normal conditions the vast majority of Zn(2+) in the blood is bound to human serum albumin (HSA).	Zinc	39-41	histidine rich glycoprotein	Homo sapiens	61-64
19679159-5	2009	Transient or sustained elevation of plasma fatty acid levels may therefore increase the proportion of plasma Zn(2+) associated with HRG.	Zinc	109-111	histidine rich glycoprotein	Homo sapiens	132-135
19703464-4	2009	One unanswered question about ferrochelatase involves defining the mechanism whereby some metals, such as divalent Fe, Co, Ni, and Zn, can be used by the enzyme in vitro to produce the corresponding metalloporphyrins, while other metals, such as divalent Mn, Hg, Cd, or Pb, are inhibitors of the enzyme.	Zinc	131-133	ferrochelatase	Homo sapiens	30-44
19303211-4	2009	The equilibrium data demonstrated a good fit with the Freundlich model and showed affinity in the orders: Cd&gt;Zn&gt;Ni&gt;Cu&gt;As&gt;Cr (sorbents P1, P3 and P4) and Cd&gt;Zn&gt;Ni&gt;As&gt;Cu&gt;Cr (sorbent P2).	Zinc	174-176	crystallin gamma F, pseudogene	Homo sapiens	149-162
19678840-5	2009	Our data reveal the overall fold and quaternary arrangement of the GCPIII molecule, define the architecture of the GCPIII substrate-binding cavity, and offer an experimental evidence for the presence of Zn(2+) ions in the bimetallic active site.	Zinc	203-205	folate hydrolase 1B (pseudogene)	Homo sapiens	67-73
19580749-4	2009	Histidine 328 in the S4 of Kv12.1 favors binding of Zn2+ and Cd2+, whereas the homologous residue Serine 321 in Kv10.2 contributes to effects of Mg2+ and Ni2+.	Zinc	52-56	potassium voltage-gated channel subfamily H member 8	Homo sapiens	27-33
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	13-15	matrix metallopeptidase 9	Homo sapiens	60-65
19542470-9	2009	By chelating Zn(2+), S100A12 significantly inhibited MMP-2, MMP-9, and MMP-3, and the Zn(2+)-induced S100A12 complex colocalized with these in foam cells in human atheroma.	Zinc	86-88	matrix metallopeptidase 9	Homo sapiens	60-65
19254786-7	2009	Consistent with the increased osteoclast numbers, a higher ratio of RANKL/OPG gene expression was found in bone of mutant mice fed lower Zn diets.	Zinc	137-139	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	74-77
19410459-2	2009	Many of the known HDAC inhibitors (HDACi) that are in clinical trials possess a hydroxamic acid, that is a strong Zn(2+) binding group, thereby inhibiting some of the class I and class II isoforms.	Zinc	114-116	histone deacetylase 9	Homo sapiens	18-22
19175297-11	2009	This mtl-2::GFP transgenic bioassay represents an alternative approach to quantify, both easily and quickly, a surrogate of MT in response to metal exposure (e.g., Cd, Hg, Cu, and Zn) in a variety of environments and potentially may be used for quantitative or semiquantitativebiomonitoring of metal contamination in soils and aquatic systems.	Zinc	180-182	Metallothionein-2	Caenorhabditis elegans	5-10
19192952-3	2009	Toxicity of both types of Zn was investigated using the ecologically relevant endpoints of lethality, behavior, reproduction, and transgene expression in a mtl-2::GFP (gene encoding green fluorescence protein fused onto the metallothionein-2 gene promoter) transgenic strain of C. elegans.	Zinc	26-28	Metallothionein-2	Caenorhabditis elegans	156-161
18820153-8	2009	The second protein family, Zip proteins, provides Zn transport from extracellular fluid or intracellular vesicles into the cytoplasm and has not been identified in a livestock species.	Zinc	50-52	death associated protein kinase 3	Homo sapiens	27-30
19235980-6	2009	Relatively weak (J(rad-rad) = -15 cm(-1)) through-space magnetic interactions between free radicals coordinated to the same metal center were also evidenced in the study of the diamagnetic zinc(II) complex.	Zinc	189-197	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	19-22
19235980-6	2009	Relatively weak (J(rad-rad) = -15 cm(-1)) through-space magnetic interactions between free radicals coordinated to the same metal center were also evidenced in the study of the diamagnetic zinc(II) complex.	Zinc	189-197	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	23-26
19034537-0	2009	Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3.	Zinc	16-22	aldo-keto reductase family 1 member A1	Homo sapiens	42-63
19034537-5	2009	The nature of the enzyme inhibition, the binding stoichiometry of two antibiotics per monomer, and comparable dissociation constants for the antibiotic and free (or substrate-bound) ADH imply that the association occurs as a consequence of the binding of the antibiotics to Zn(II) ion present at the structural center.	Zinc	274-280	aldo-keto reductase family 1 member A1	Homo sapiens	182-185
19141082-7	2009	Zn also prevented Abeta degradation by the proteases neprilysin and insulin degrading enzyme.	Zinc	0-2	insulin degrading enzyme	Homo sapiens	68-92
19098122-6	2009	In accordance with findings that Zn(2+) can rescue reduced DA uptake in mutant transporters that are predominantly inward-facing, micromolar concentrations of Zn(2+) markedly potentiated [(3)H]dopamine uptake in T62D-hDAT and permitted the measurement of amphetamine-stimulated dopamine efflux.	Zinc	159-161	solute carrier family 6 member 3	Homo sapiens	217-221
19073193-6	2009	The higher affinity binding site disappears upon inactivation of IDE by ethylenediaminetetraacetic acid, which chelates the catalytic Zn(2+) ion.	Zinc	134-136	insulin degrading enzyme	Homo sapiens	65-68
19000913-1	2009	The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein.	Zinc	189-191	solute carrier family 6 member 3	Homo sapiens	4-24
19000913-1	2009	The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein.	Zinc	189-191	solute carrier family 6 member 3	Homo sapiens	26-29
19000913-2	2009	Herein, we report a host-cell-specific direction of the Zn(2+) effect on wild type DAT.	Zinc	56-58	solute carrier family 6 member 3	Homo sapiens	83-86
19000913-3	2009	Whereas low mumolar Zn(2+) decreased dopamine uptake by DAT expressing HEK293 cells, it stimulated uptake by DAT expressing SK-N-MC cells.	Zinc	20-22	solute carrier family 6 member 3	Homo sapiens	56-59
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Zinc	205-207	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	26-32
19054339-5	2009	When expressed in yeast TcNRAMP3 and TcNRAMP4 transport the same metals as their respective A. thaliana orthologues: iron (Fe), manganese (Mn) and cadmium (Cd) but not zinc (Zn) for NRAMP3; Fe, Mn, Cd and Zn for NRAMP4.	Zinc	205-207	natural resistance associated macrophage protein 4	Arabidopsis thaliana	39-45
19054339-7	2009	Inactivation of AtNRAMP3 and AtNRAMP4 in A. thaliana results in strong Cd and Zn hypersensitivity, which is fully rescued by TcNRAMP3 or TcNRAMP4 expression.	Zinc	78-80	natural resistance-associated macrophage protein 3	Arabidopsis thaliana	16-24
19054339-7	2009	Inactivation of AtNRAMP3 and AtNRAMP4 in A. thaliana results in strong Cd and Zn hypersensitivity, which is fully rescued by TcNRAMP3 or TcNRAMP4 expression.	Zinc	78-80	natural resistance associated macrophage protein 4	Arabidopsis thaliana	29-37
18691948-7	2008	Anti-mesothelin antibody-conjugated CdSe/CDS/ZnS quantum rods were synthesized, and confocal bioimaging confirmed robust binding to JH-EsoAd1 cells.	Zinc	45-48	mesothelin	Homo sapiens	5-15
18985247-4	2008	beta-Pb2ZnF6 has one six-fold coordinated Zn, one eleven-fold coordinated Pb and five F non-equivalent crystallographic sites and is built from alternated layers parallel to the (a, b) plane; tilted ZnF4(2-) layers of corner sharing ZnF6(4-) octahedra and FPb+ layers of edge sharing FPb4(7+) tetrahedra.	Zinc	8-10	ZNF4	Homo sapiens	199-203
18658230-8	2008	In contrast, the effect of Zn(2+) on the ClC-0 channel, Zn(2+)-mediated inhibition of hClC-4 is minimally voltage-dependent, suggesting an extracellular binding site for the ion.	Zinc	27-29	Charcot-Leyden crystal galectin	Homo sapiens	41-44
18658230-8	2008	In contrast, the effect of Zn(2+) on the ClC-0 channel, Zn(2+)-mediated inhibition of hClC-4 is minimally voltage-dependent, suggesting an extracellular binding site for the ion.	Zinc	27-33	Charcot-Leyden crystal galectin	Homo sapiens	41-44
18470600-2	2008	The developed probe FR exhibited great ratiometric fluorescence enhancement and remarkable yellow-magenta color change toward Hg2+ with excellent selectivity in aqueous acetone solution, and the ratiometric fluorescence response to Hg2+ was not interfered by other metal cations including Fe3+, Co2+, Ni2+, Cr3+, Zn2+, Pb2+, Cd2+, Ca2+, Mg2+, Ba2+ and Mn2+.	Zinc	313-317	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	126-129
18470600-2	2008	The developed probe FR exhibited great ratiometric fluorescence enhancement and remarkable yellow-magenta color change toward Hg2+ with excellent selectivity in aqueous acetone solution, and the ratiometric fluorescence response to Hg2+ was not interfered by other metal cations including Fe3+, Co2+, Ni2+, Cr3+, Zn2+, Pb2+, Cd2+, Ca2+, Mg2+, Ba2+ and Mn2+.	Zinc	313-317	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	232-235
18936217-8	2008	After the Fe+Zn period, FRAP values tended to increase (P = 0.1), delta-ALAD activity and EOF returned to baseline values, and Zn-delta-ALAD% decreased (P &lt; 0.001) compared with baseline.	Zinc	127-129	aminolevulinate dehydratase	Homo sapiens	136-140
18700180-7	2008	The chaperonic property of alpha(s)-casein, which enables it to inhibit thermal aggregation of alcohol dehydrogenase, is shown to be partially destroyed by Zn(II)-induced structural alterations, due possibly to loss of flexibility of the natively unfolded casein chains.	Zinc	156-162	aldo-keto reductase family 1 member A1	Bos taurus	95-116
18684507-6	2008	A comparison of binding geometries where Pb(2+) has replaced Ca(2+) in calmodulin (CaM) and Zn(2+) in 5-aminolaevulinic acid dehydratase (ALAD) revealed protein structural changes that appear to be unrelated to ionic displacement.	Zinc	92-94	aminolevulinate dehydratase	Homo sapiens	102-136
18799003-11	2008	Seven transcripts exhibiting differential expression in pigs fed pharmacological Zn with sequence similarities to genes encoding GLO1, PRDX4, ACY1, ORM1, CPB2, GSTM4, and HSP70.2 were selected for confirmation.	Zinc	81-83	lactoylglutathione lyase	Sus scrofa	129-133
19194929-3	2008	The results showed that the molar ratio of Zn(2+) to EDTA = 1:1 was crucial for SRB growth and ZnS synthesis.	Zinc	43-45	chaperonin containing TCP1 subunit 4	Homo sapiens	80-83
19194929-4	2008	At the ratio(n) (Zn2+)/n) (EDTA) = 1:1, lower Zn(2+) concentration enhanced both the growth of SRB and the reduction of SO(4) (2-), leading to higher ZnS production.	Zinc	17-21	chaperonin containing TCP1 subunit 4	Homo sapiens	95-98
19194929-4	2008	At the ratio(n) (Zn2+)/n) (EDTA) = 1:1, lower Zn(2+) concentration enhanced both the growth of SRB and the reduction of SO(4) (2-), leading to higher ZnS production.	Zinc	46-52	chaperonin containing TCP1 subunit 4	Homo sapiens	95-98
19194929-4	2008	At the ratio(n) (Zn2+)/n) (EDTA) = 1:1, lower Zn(2+) concentration enhanced both the growth of SRB and the reduction of SO(4) (2-), leading to higher ZnS production.	Zinc	150-153	chaperonin containing TCP1 subunit 4	Homo sapiens	95-98
18640604-8	2008	When the recombinant strain B3 established symbiosis with A. sinicus, the introduction of AtIRT1 in the recombinant strain B3 advantaged the accumulation of Cu and As in the nodules of A. sinicus, compared with that of Cd and Zn.	Zinc	226-228	iron-regulated transporter 1	Arabidopsis thaliana	90-96
18272153-6	2008	The adhesion of MRP14 to amastigotes was reproduced in vitro and enhanced in the presence of Ca2+ and Zn2+.	Zinc	102-106	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	16-21
18483295-3	2008	Like vorinostat, most of the small-molecule HDAC inhibitors in clinical development are hydroxamic acids, whose inhibitory activity stems from their ability to coordinate the catalytic Zn2+ in the active site of HDACs.	Zinc	185-189	histone deacetylase 9	Homo sapiens	44-48
17963238-3	2008	Zn(2+) can bind to the reduced Tim10, but not disulphide bonded (oxidized) protein.	Zinc	0-2	translocase of inner mitochondrial membrane 10	Homo sapiens	31-36
17963238-6	2008	At equilibrium, coupled with the use of protein fluorescence and metal chelators, the zinc-binding affinity was determined for Tim10 to be about 8 x 10(-10)M. Then, far UV CD was used to investigate the secondary structure change upon zinc-binding of the same set of protein samples at various free Zn(2+) concentrations.	Zinc	299-305	translocase of inner mitochondrial membrane 10	Homo sapiens	127-132
18027885-7	2008	P2X4 receptors are likely involved because the calcium response to BzATP was inhibited by Cu(2+), and the P2X4 modulators Zn(2+) and ivermectin (0.3-3 microM) each increased intracellular [Ca(2+)].	Zinc	122-124	purinergic receptor P2X 4	Rattus norvegicus	0-4
18027885-7	2008	P2X4 receptors are likely involved because the calcium response to BzATP was inhibited by Cu(2+), and the P2X4 modulators Zn(2+) and ivermectin (0.3-3 microM) each increased intracellular [Ca(2+)].	Zinc	122-124	purinergic receptor P2X 4	Rattus norvegicus	106-110
17475461-7	2007	Dietary Zn supplementation reduced expression of the SCF gene at both mRNA and protein levels, the number of mast cells in the mucosa and submucosa of the small intestine and histamine release from mucosal mast cells.	Zinc	8-10	KIT ligand	Sus scrofa	53-56
17881000-4	2007	While the overall structure and the specificity of S1 pocket for basic side-chains were similar to that of hK4, a closely related family member, both differed in their interaction with Zn2+.	Zinc	185-189	keratin 4	Homo sapiens	107-110
17881000-6	2007	Instead, Zn2+ binds adjacent to the active site, becoming coordinated by the imidazole rings of His99 and His96 not present in hK4.	Zinc	9-13	keratin 4	Homo sapiens	127-130
17881000-8	2007	Modeling studies show that in the absence of bound leupeptin, Zn2+ is likely further coordinated by the imidazolyl side-chain of the catalytic His57 which can, similar to equivalent His57 imidazole groups in the related rat kallikrein proteinase tonin and in an engineered metal-binding rat trypsin, rotate out of its triad position to provide the third co-ordination site of the bound Zn2+, rendering Zn2+-bound hK5 inactive.	Zinc	62-66	kallikrein 1-related peptidase C2	Rattus norvegicus	246-251
17989465-1	2007	In the title complex, [Zn(C(12)H(6)O(4))(H(2)O)](n), a Zn(II) polymer based on naphthalene-1,8-dicarboxylate (1,8-nap), the Zn(II) atoms adopt an elongated octahedral coordination geometry.	Zinc	23-25	catenin beta like 1	Homo sapiens	79-82
17989465-1	2007	In the title complex, [Zn(C(12)H(6)O(4))(H(2)O)](n), a Zn(II) polymer based on naphthalene-1,8-dicarboxylate (1,8-nap), the Zn(II) atoms adopt an elongated octahedral coordination geometry.	Zinc	55-61	catenin beta like 1	Homo sapiens	79-82
17636324-8	2007	Results are consistent with the view that CAX2 and CAX4 antiporters of tonoplast play a role in tolerance to high, toxic levels of Cd, Zn, and Mn in tobacco.	Zinc	135-137	cation exchanger 4	Arabidopsis thaliana	51-55
17869271-4	2007	Our data demonstrate that exchanging Cys for His and vice versa in the highly conserved Zn-coordinating HCCH motif disrupted Vif function and interaction with Cul5.	Zinc	88-90	Vif	Human immunodeficiency virus 1	125-128
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	97-103
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	197-203
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	41-45	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	248-254
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	197-203
17526568-4	2007	We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2&gt;CaV3.2&gt;CaV2.3&gt;CaV2.2=CaV 2.1&gt;or=CaV3.3=CaV3.1.	Zinc	164-168	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	248-254
17560002-9	2007	Zn administration to the Cd-exposed rats enhanced the bone ALP activity and prevented Cd-induced bone resorption, but had no statistically significant effect on BMC and BMD; however, mean values of the densitometric parameters in the rats receiving both Cd and Zn were higher than in those treated with Cd alone.	Zinc	0-2	PDZ and LIM domain 3	Rattus norvegicus	59-62
17595415-7	2007	Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6.	Zinc	15-17	CD8a molecule	Homo sapiens	75-78
17257026-6	2007	On the other hand, ferrocenylthiazole 9, in which the heterocyclic ring and the ferrocene group are linked across the 2 position, is a selective redox sensor for Hg2+ metal ions, and it responds optically, as does bis(thiazolyl)ferrocene 11, to a narrow range of cations (Zn2+, Cd2+, Hg2+, Ni2+, and Pb2+).	Zinc	272-276	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	162-165
17257026-7	2007	Finally, bis(ferrocenyl)thiazole 5 is a dual optical and redox sensor for Zn2+, Cd2+, Hg2+, Ni2+, and Pb2+, whereas bis(ferrocenyl) compound 7, bearing a bis(thiazole) unit as a bridge, is only a chromogenic sensor for Zn2+, Cd2+, Hg2+, Ni2+, and Pb2+.	Zinc	74-78	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	231-234
17257026-7	2007	Finally, bis(ferrocenyl)thiazole 5 is a dual optical and redox sensor for Zn2+, Cd2+, Hg2+, Ni2+, and Pb2+, whereas bis(ferrocenyl) compound 7, bearing a bis(thiazole) unit as a bridge, is only a chromogenic sensor for Zn2+, Cd2+, Hg2+, Ni2+, and Pb2+.	Zinc	219-223	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	86-89
17096706-8	2007	The interaction between GPIbalpha and dimeric beta2GPI was of intermediate affinity (Kd = 180 nM) and Zn2+, but not Ca2+-dependent.	Zinc	102-106	glycoprotein Ib platelet subunit alpha	Homo sapiens	24-33
17217066-3	2007	TRPM7 is a divalent cation-selective ion channel that is permeable to Ca2+ and Mg2+, but also conducts essential metals such as Zn2+, Mn2+, and Co2+, as well as nonphysiologic or toxic metals such as Ni2+, Cd2+, Ba2+, and Sr2+.	Zinc	128-132	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-5
17300980-3	2007	AT3 variants showed an intrinsic propensity to misfolding/aggregation; on the other hand, Zn(2+) and Al(3+) strongly stimulated the amplitude and kinetics of these conformational conversions.	Zinc	90-92	ataxin 3	Homo sapiens	0-3
17300980-7	2007	The observation that Zn(2+) and Al(3+) promote AT3 fibrillogenesis is consistent with similar results found for other amyloidogenic molecules, such as beta-amyloid and prion proteins.	Zinc	21-23	ataxin 3	Homo sapiens	47-50
17300980-9	2007	Studies of liposomes as membrane models showed dramatic changes in the structural properties of the lipid bilayer in the presence of AT3, which were enhanced after supplementing the protein with Zn(2+) and Al(3+).	Zinc	195-197	ataxin 3	Homo sapiens	133-136
17344088-3	2007	Apf always produces an NTP product, with substrate preference depending on pH and divalent ion (Zn(2+) or Mg(2+)).	Zinc	96-102	diadenosine tetraphosphate hydrolase	Drosophila melanogaster	0-3
17082234-7	2007	Consequently, application of Zn2+ results in a significant increase in CaV3.3 current in action potential clamp experiments, while CaV3.1 and CaV3.2 currents are significantly reduced.	Zinc	29-33	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	71-77
17034122-1	2006	A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution.	Zinc	2-10	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
16939284-2	2006	Upon addition of the cis form of 1,2-bispyridylethylene (cis-2) to (+)-1 ([cis-2]/[(+)-1] = 5.0), an enantiomer of 1, the intramolecular Zn-N coordination bonds in (+)-1 are readily cleaved to form an externally locked, cyclodimeric one-to-one complex (+)-1 subset cis-2, accompanying a rotation of the ferrocene module, as visualized by CD spectroscopy.	Zinc	137-139	suppressor of cytokine signaling 2	Homo sapiens	57-62
16723513-10	2006	Furthermore, we found Zn(2+)-exposed PAECs exhibited a significant reduction in mitochondrial membrane potential, loss of cardiolipin from the inner leaflet, caspase activation, and significant increases in TdT-mediated dUTP nick end labeling-positive cells.	Zinc	22-28	DNA nucleotidylexotransferase	Homo sapiens	207-210
16772438-10	2006	In both experiments, the villous height of the small-intestinal mucosa and both the mRNA and protein levels for IGF-I and IGF-IR in the small intestine were markedly enhanced (P &lt; 0.05) by feeding elevated levels of Zn.	Zinc	219-221	insulin like growth factor 1 receptor	Sus scrofa	122-128
16772438-12	2006	Collectively, these results suggest that dietary Zn supplementation exerts its beneficial effects on the intestinal growth of weanling piglets through increasing IGF-I and IGF-IR expression in the small-intestinal mucosa.	Zinc	49-51	insulin like growth factor 1 receptor	Sus scrofa	172-178
16611630-8	2006	The COMP-degrading activity of ADAMTS-12 requires the presence of Zn2+ and appropriate pH (7.5-9.5), and the level of ADAMTS-12 in the cartilage and synovium of patients with both osteoarthritis and rheumatoid arthritis is significantly higher than in normal cartilage and synovium.	Zinc	66-70	cartilage oligomeric matrix protein	Homo sapiens	4-8
16611630-8	2006	The COMP-degrading activity of ADAMTS-12 requires the presence of Zn2+ and appropriate pH (7.5-9.5), and the level of ADAMTS-12 in the cartilage and synovium of patients with both osteoarthritis and rheumatoid arthritis is significantly higher than in normal cartilage and synovium.	Zinc	66-70	ADAM metallopeptidase with thrombospondin type 1 motif 12	Homo sapiens	31-40
16581305-0	2006	Response of catalase activity to Ag+, Cd2+, Cr6+, Cu2+ and Zn2+ in five tissues of freshwater fish Oreochromis niloticus.	Zinc	59-63	catalase	Oreochromis niloticus	12-20
16373669-7	2006	Moreover, Zn(2+) exposure of BEAS-2B cells induced the phosphorylation of the AP-1 proteins c-Fos and c-Jun.	Zinc	10-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
16373669-7	2006	Moreover, Zn(2+) exposure of BEAS-2B cells induced the phosphorylation of the AP-1 proteins c-Fos and c-Jun.	Zinc	10-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Zinc	146-148	histidine rich glycoprotein	Homo sapiens	19-46
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Zinc	146-148	histidine rich glycoprotein	Homo sapiens	48-52
16436387-5	2006	We now show that HRGP330 binds heparin/HS with the same capacity as full-length HRGP, and the binding is Zn(2+)-dependent.	Zinc	105-107	histidine rich glycoprotein	Homo sapiens	17-21
16483601-11	2006	On the basis of the above observations, we propose a mechanism for Zap1 transcriptional regulation in which zf1-zf2 interactions stabilize the betabetaalpha folded "repressed state" of the zf2 activation domain in the presence of cellular Zn(II) excess.	Zinc	239-245	Zap1p	Saccharomyces cerevisiae S288C	67-71
16354767-6	2006	Mibefradil failed to discriminate well among the functional 2PK+ channels; however, Zn2+ and Hg2+ exerted a significantly stronger inhibitory effect on TRESK than on the other channels.	Zinc	84-88	potassium channel, subfamily K, member 18	Mus musculus	152-157
16354767-8	2006	Whereas both Zn2+ and Hg2+ were selective blockers of TRESK among the mouse 2PK+ channels, human TRESK was resistant to Zn2+; it was blocked only by Hg2+.	Zinc	13-17	potassium channel, subfamily K, member 18	Mus musculus	54-59
16354767-11	2006	Thus, both Zn2+ and Hg2+ are expected to inhibit endogenous TRESK in isolated mouse cells, and these ions can be applied to identify the calcineurin-activated 2PK+ channel in its natural environment.	Zinc	11-15	potassium channel, subfamily K, member 18	Mus musculus	60-65
16603817-3	2006	To investigate the effects of divalent cations on the dehydrogenase activity of Xenopus laevis ALDH1A1, the formation of acetate and retinoic acid from acetaldehyde and retinal, respectively, was investigated in the presence of Ca2+, Mg2+, Mn2+ or Zn2+.	Zinc	248-252	aldehyde dehydrogenase 1 family member A1 L homeolog	Xenopus laevis	95-102
16466645-7	2006	In addition, Zn(2+), which has been reported to be a potent inhibitor of GAT3, was found to have a significantly but partially inhibitory effect on the Na(+)-dependent GABA transport in a concentration-dependent manner.	Zinc	13-15	solute carrier family 6 member 11	Rattus norvegicus	73-77
16411690-6	2006	Both Me(2)ZP1 and Me(4)ZP1 can enter HeLa cells and signal the presence of Zn(2+).	Zinc	75-77	zona pellucida glycoprotein 1	Homo sapiens	10-13
16411690-6	2006	Both Me(2)ZP1 and Me(4)ZP1 can enter HeLa cells and signal the presence of Zn(2+).	Zinc	75-77	zona pellucida glycoprotein 1	Homo sapiens	23-26
16286448-5	2005	Histochemical analyses of the WAKL4 promoter fused with the -glucuronidase reporter gene have shown that WAKL4 expression is induced by Na+, K+, Cu2+, Ni2+, and Zn2+.	Zinc	161-165	wall associated kinase-like 4	Arabidopsis thaliana	30-35
16286448-5	2005	Histochemical analyses of the WAKL4 promoter fused with the -glucuronidase reporter gene have shown that WAKL4 expression is induced by Na+, K+, Cu2+, Ni2+, and Zn2+.	Zinc	161-165	wall associated kinase-like 4	Arabidopsis thaliana	105-110
16286448-8	2005	Semiquantitative and quantitative reverse transcription-PCR analyses showed that the promoter impairment abolished WAKL4-induced expression by Na+, K+, Cu2+, and Zn2+, but not by Ni2+.	Zinc	162-166	wall associated kinase-like 4	Arabidopsis thaliana	115-120
16286448-9	2005	Whereas the WAKL4 promoter impairment resulted in hypersensitivity to K+, Na+, Cu2+, and Zn2+, it conferred a better tolerance to toxic levels of the Ni2+ heavy metal.	Zinc	89-93	wall associated kinase-like 4	Arabidopsis thaliana	12-17
16286448-10	2005	WAKL4 was required for the up-regulation of zinc transporter genes during zinc deficiency, and the WAKL4 T-DNA insertion resulted in a reduction of Zn2+ accumulation in shoots.	Zinc	148-152	wall associated kinase-like 4	Arabidopsis thaliana	99-104
16235193-6	2005	We discuss as a possible solution to this paradoxical situation that EL2+ is an isolated antisite at room temperature, which at low temperature, where all magnetic resonance experiments are performed, associates itself with shallow acceptors such as Zn(Ga)- more than two nearest neighbour distances away.	Zinc	250-252	spectrin alpha, erythrocytic 1	Homo sapiens	69-72
16129457-7	2005	It was not possible, however, to transfer to TnaT binding sites for another metal ion, Zn(2+), that we previously engineered in the dopamine (DAT) and GABA (GAT-1) transporters between TM 7 and 8.	Zinc	87-89	solute carrier family 6 member 3	Homo sapiens	142-145
16140324-7	2005	Moreover, ferrochelatase catalyses insertion of Cu(II) and Zn(II) into N-MeMP with a rate that is about 20 times faster than non-enzymatic metallation in solution, suggesting that the catalytic strategy of ferrochelatase includes a stage of acceleration of the rate of ligand exchange for the metal substrate.	Zinc	59-65	ferrochelatase	Homo sapiens	10-24
16140324-7	2005	Moreover, ferrochelatase catalyses insertion of Cu(II) and Zn(II) into N-MeMP with a rate that is about 20 times faster than non-enzymatic metallation in solution, suggesting that the catalytic strategy of ferrochelatase includes a stage of acceleration of the rate of ligand exchange for the metal substrate.	Zinc	59-65	ferrochelatase	Homo sapiens	206-220
16008515-4	2005	hRIP alpha is the longest isoform with 219 residues, containing a N-terminal arginine-rich basic region, followed by an acidic region and two C-terminal Zn finger-like structures.	Zinc	153-155	RPA interacting protein	Homo sapiens	0-4
15823027-7	2005	These structural changes upon Zn(2+)-binding could explain the 5-fold increase in affinity that Zn(2+)-Ca(2+)-bound S100B has for peptide targets such as the TRTK peptide versus Ca(2+)-bound S100B.	Zinc	30-36	S100 calcium binding protein B	Rattus norvegicus	116-121
15823027-7	2005	These structural changes upon Zn(2+)-binding could explain the 5-fold increase in affinity that Zn(2+)-Ca(2+)-bound S100B has for peptide targets such as the TRTK peptide versus Ca(2+)-bound S100B.	Zinc	30-36	S100 calcium binding protein B	Rattus norvegicus	191-196
15823027-7	2005	These structural changes upon Zn(2+)-binding could explain the 5-fold increase in affinity that Zn(2+)-Ca(2+)-bound S100B has for peptide targets such as the TRTK peptide versus Ca(2+)-bound S100B.	Zinc	96-102	S100 calcium binding protein B	Rattus norvegicus	116-121
15823027-7	2005	These structural changes upon Zn(2+)-binding could explain the 5-fold increase in affinity that Zn(2+)-Ca(2+)-bound S100B has for peptide targets such as the TRTK peptide versus Ca(2+)-bound S100B.	Zinc	96-102	S100 calcium binding protein B	Rattus norvegicus	191-196
15823027-9	2005	Changes in conformation such as these could contribute to the order of magnitude higher affinity that S100B has for calcium in the presence of Zn(2+).	Zinc	143-145	S100 calcium binding protein B	Rattus norvegicus	102-107
15748207-2	2005	HRG ligands include Zn(2+) and haem, tropomyosin, heparin and heparan sulphate, plasminogen, plasmin, fibrinogen, thrombospondin, IgG, FcgammaR and complement.	Zinc	20-22	histidine rich glycoprotein	Homo sapiens	0-3
15748207-5	2005	HRG binds to most cells primarily via heparan sulphate proteoglycans, binding which is also potentiated by elevated free Zn(2+) levels and low pH.	Zinc	121-124	histidine rich glycoprotein	Homo sapiens	0-3
15736926-3	2005	Metallothionein-3 (Zn(7)MT-3) has been proposed to be involved in the intracellular trafficking of Zn(2+) in zinc-containing neurons, but its role in this process is not understood.	Zinc	19-21	metallothionein 3	Homo sapiens	0-17
15710632-1	2005	AtMHX is an Arabidopsis tonoplast transporter that can exchange protons with Mg2+ and Zn2+ ions.	Zinc	86-90	magnesium/proton exchanger	Arabidopsis thaliana	0-5
15632982-5	2004	The removal of Zn, Cd, and Hg in soil GHL within the range of HCl concentrations was 8.2-16.5, 12.2-19.1, and 4.3-6.9 whereas these were 6.5-7.6, 8.5-14.1, and 3.2-5.2 in soil KAP.	Zinc	15-17	growth hormone 2	Homo sapiens	38-41
15632982-6	2004	The removal of Zn, Cd, and Hg in soil GHL within the range of Mg(NO3)2 concentrations were 12.2-28.5, 19.1-24.6, and 18.2-19.1 whereas these were 9.1-12.1, 8.3-12.1, and 10.6-48.1 in soil KAP.	Zinc	15-17	growth hormone 2	Homo sapiens	38-41
15519292-5	2004	Here, cathepsin B (cat B) was found to be inhibited by Zn2+, Fe3+, and Cu2+ (1-50 microM) under excess GSH or DTT protease activators (6 mM).	Zinc	55-59	cathepsin B	Homo sapiens	6-17
15358780-1	2004	Binding of Zn(2+) to an endogenous binding site in the dopamine transporter (DAT) leads to inhibition of dopamine (DA) uptake and enhancement of carrier-mediated substrate efflux.	Zinc	11-13	solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog	Xenopus laevis	55-75
15358780-1	2004	Binding of Zn(2+) to an endogenous binding site in the dopamine transporter (DAT) leads to inhibition of dopamine (DA) uptake and enhancement of carrier-mediated substrate efflux.	Zinc	11-13	solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog	Xenopus laevis	77-80
15358780-5	2004	These data suggest that Zn(2+) facilitates an uncoupled ion conductance mediated by DAT.	Zinc	24-30	solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog	Xenopus laevis	84-87
15358780-10	2004	The data suggest that by potentiating an uncoupled Cl(-) conductance, Zn(2+) is capable of modulating the membrane potential of cells expressing DAT and as a result cause simultaneous inhibition of uptake and enhancement of efflux.	Zinc	70-76	solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog	Xenopus laevis	145-148
15331685-6	2004	STICs were abolished by the P2X antagonist PPADS and potentiated by Zn2+, suggesting they were mediated by P2X2 receptor activation.	Zinc	68-72	purinergic receptor P2X 2	Rattus norvegicus	107-111
15158018-1	2004	In normal gerbils, intracellular zinc ions ([Zn2+]i) and calcium ions ([Ca2+]i) accumulate in hippocampal CA1 neurons after global ischemia.	Zinc	45-49	carbonic anhydrase 1	Homo sapiens	106-109
15158018-3	2004	In normal slices, large increases in [Zn2+]i and [Ca2+]i were observed in the stratum radiatum of the CA1 area after oxygen-glucose deprivation.	Zinc	38-42	carbonic anhydrase 1	Homo sapiens	102-105
15158018-4	2004	In preconditioned slices, there were significantly decreased peak levels of [Zn2+]i and [Ca2+]i in CA1.	Zinc	77-81	carbonic anhydrase 1	Homo sapiens	99-102
15056725-2	2004	Parenchymal beta-amyloid deposition is dependent on the activity of zinc transporter 3 (ZnT3), a neocortical synaptic vesicle membrane protein that causes enrichment of exchangeable Zn2+ in the vesicle, which is externalized on neurotransmission.	Zinc	182-186	solute carrier family 30 (zinc transporter), member 3	Mus musculus	68-86
15056725-2	2004	Parenchymal beta-amyloid deposition is dependent on the activity of zinc transporter 3 (ZnT3), a neocortical synaptic vesicle membrane protein that causes enrichment of exchangeable Zn2+ in the vesicle, which is externalized on neurotransmission.	Zinc	182-186	solute carrier family 30 (zinc transporter), member 3	Mus musculus	88-92
15056725-5	2004	This histochemically reactive Zn2+ is enriched in CAA in a transgenic mouse model of AD (Tg2576), and a dramatic reduction of CAA occurs after targeted disruption of the Znt3 gene in these mice.	Zinc	30-34	solute carrier family 30 (zinc transporter), member 3	Mus musculus	170-174
15056725-6	2004	Also, in Znt3 knock-out mice, the amount of exchangeable Zn2+ [detected by N-(6-methoxy-8-quinolyl)-p-carboxybenzoylsulphonamide (TFL-Zn)] in the perivascular space was significantly decreased in the neocortex but not in peripheral organs.	Zinc	57-61	solute carrier family 30 (zinc transporter), member 3	Mus musculus	9-13
15056725-8	2004	Thus, synaptic ZnT3 activity may promote CAA by indirectly raising exchangeable Zn2+ concentrations in the perivascular spaces of the brain.	Zinc	80-84	solute carrier family 30 (zinc transporter), member 3	Mus musculus	15-19
15032707-3	2004	Zn(2+) may enter neurons through NMDA channels, voltage-sensitive calcium channels, Ca(2+)-permeable AMPA/kainate (Ca-A/K) channels, or Zn(2+)-sensitive membrane transporters.	Zinc	0-2	teashirt zinc finger homeobox 1	Homo sapiens	115-121
14594813-11	2004	Zn(2+) and Co(2+) inhibited ChaK1-cat kinase activity.	Zinc	0-2	transient receptor potential cation channel subfamily M member 7	Homo sapiens	28-33
14725469-3	2004	Cu and Zn complexes of Ar(4)TBP"s are further demetalated to give the corresponding Ar(4)TBP free bases.	Zinc	7-9	TATA-box binding protein	Homo sapiens	28-31
14725469-3	2004	Cu and Zn complexes of Ar(4)TBP"s are further demetalated to give the corresponding Ar(4)TBP free bases.	Zinc	7-9	TATA-box binding protein	Homo sapiens	89-92
14704068-5	2004	Of the two types of acids in I, acid-1 has all the oxygen atoms connected to Zn with monodendate connectivity and acid-2 has only four monodendate connectivity and possesses four terminal C-O linkage.	Zinc	77-79	mediator complex subunit 25	Homo sapiens	32-38
14658877-1	2003	The molecular recognition properties of dizinc(II) bisporphyrin anchored by dibenzofuran (DPD), Zn2(DPD) (1), were evaluated as a strategy for utilizing the Pacman effect to control the excited-state properties of cofacial bisporphyrin motifs.	Zinc	96-99	dihydropyrimidine dehydrogenase	Homo sapiens	90-93
14658877-1	2003	The molecular recognition properties of dizinc(II) bisporphyrin anchored by dibenzofuran (DPD), Zn2(DPD) (1), were evaluated as a strategy for utilizing the Pacman effect to control the excited-state properties of cofacial bisporphyrin motifs.	Zinc	96-99	dihydropyrimidine dehydrogenase	Homo sapiens	100-103
14506276-9	2003	The Zn2+ binding amino acids (conserved in PGRP-L and T7 amidase) and Cys-419 (not conserved in T7 amidase) are required for the amidase activity of PGRP-L, whereas three other amino acids, needed for the activity of T7 amidase, are not required for the activity of PGRP-L.	Zinc	4-8	peptidoglycan recognition protein 2	Homo sapiens	149-155
14506276-9	2003	The Zn2+ binding amino acids (conserved in PGRP-L and T7 amidase) and Cys-419 (not conserved in T7 amidase) are required for the amidase activity of PGRP-L, whereas three other amino acids, needed for the activity of T7 amidase, are not required for the activity of PGRP-L.	Zinc	4-8	peptidoglycan recognition protein 2	Homo sapiens	149-155
32689086-5	2003	Divalent cations including Ca2+, Mg2+, Zn2+ and Cu2+ altered A6PR activity.	Zinc	39-43	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	61-65
14608047-2	2003	We demonstrated Zn transporter expression (Zip3, ZnT-1, ZnT-2 and ZnT-4) in rat mammary gland during mid-lactation and we hypothesize that changes in the levels and localization of these transporters play a role in the longitudinal decrease in milk Zn concentration.	Zinc	16-18	solute carrier family 30 member 2	Rattus norvegicus	56-61
14608047-2	2003	We demonstrated Zn transporter expression (Zip3, ZnT-1, ZnT-2 and ZnT-4) in rat mammary gland during mid-lactation and we hypothesize that changes in the levels and localization of these transporters play a role in the longitudinal decrease in milk Zn concentration.	Zinc	16-18	solute carrier family 30 member 4	Rattus norvegicus	66-71
14608047-8	2003	Zn-treated HC11 cells had lower 65Zn uptake and ZIP3 mRNA levels and higher 65Zn export, ZnT-1 and ZnT-2 mRNA levels than untreated cells.	Zinc	0-2	solute carrier family 30 member 2	Rattus norvegicus	99-104
14608047-9	2003	Zn treatment resulted in relocalization from the plasma membrane (Zip3) or Golgi apparatus (ZnT-4) to an intracellular compartment, from an intracellular compartment toward the plasma membrane (ZnT-2) or from a perinuclear to an intracellular compartment (ZnT-1).	Zinc	0-2	solute carrier family 30 member 4	Rattus norvegicus	92-97
14608047-9	2003	Zn treatment resulted in relocalization from the plasma membrane (Zip3) or Golgi apparatus (ZnT-4) to an intracellular compartment, from an intracellular compartment toward the plasma membrane (ZnT-2) or from a perinuclear to an intracellular compartment (ZnT-1).	Zinc	0-2	solute carrier family 30 member 2	Rattus norvegicus	194-199
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	141-143	complement factor H	Homo sapiens	79-87
14522582-3	2003	We found that the cofactor activity of C4b-binding protein towards C4b/C3b and factor H towards C3b increase at micromolar concentrations of Zn(2+) and are abolished at 2 mM Zn(2+) and above.	Zinc	174-176	complement factor H	Homo sapiens	79-87
14566877-13	2003	Cyclam NH hydrogen bonding is prevalent both in the solid state and in solution, and is relevant to the anti-HIV activity of Zn(II) and other metal cyclam complexes and to their ability to recognize the CXCR4 transmembrane co-receptor.	Zinc	125-131	C-X-C motif chemokine receptor 4	Homo sapiens	203-208
12885774-11	2003	In contrast to NPPs, alk-SMase activity was not stimulated by divalent metal ions but inhibited by Zn2+.	Zinc	99-103	ALK receptor tyrosine kinase	Homo sapiens	21-24
14555487-4	2003	Here, we investigated the role of the C-terminal Zn-binding domain of Rpa135, the second-largest subunit of yeast RNA polymerase I.	Zinc	49-51	DNA-directed RNA polymerase I core subunit RPA135	Saccharomyces cerevisiae S288C	70-76
14555487-5	2003	Analysis of nonfunctional Rpa135 mutants indicated that the Zn-binding domain is required for recruitment of the largest subunit, Rpa190, into the RNA polymerase I complex.	Zinc	60-62	DNA-directed RNA polymerase I core subunit RPA135	Saccharomyces cerevisiae S288C	26-32
14555487-5	2003	Analysis of nonfunctional Rpa135 mutants indicated that the Zn-binding domain is required for recruitment of the largest subunit, Rpa190, into the RNA polymerase I complex.	Zinc	60-62	DNA-directed RNA polymerase I core subunit RPA190	Saccharomyces cerevisiae S288C	130-136
14555487-6	2003	Curiously, the essential function of the Rpa135 Zn-binding domain is not related to Zn(2+) binding per se, since replacement of only one of the four cysteine residues with alanine led to the loss of Rpa135 function.	Zinc	48-50	DNA-directed RNA polymerase I core subunit RPA135	Saccharomyces cerevisiae S288C	41-47
14555487-6	2003	Curiously, the essential function of the Rpa135 Zn-binding domain is not related to Zn(2+) binding per se, since replacement of only one of the four cysteine residues with alanine led to the loss of Rpa135 function.	Zinc	48-50	DNA-directed RNA polymerase I core subunit RPA135	Saccharomyces cerevisiae S288C	199-205
14552375-11	2003	Excess Zn increased (P &lt; 0.08) ADG and ADFI in Phase 2 and 3 and overall.	Zinc	7-9	ADG	Sus scrofa	34-37
14552375-15	2003	Excess Zn decreased (P &lt; 0.09) ADG in Phase 1 but increased (P &lt; 0.09) ADG and ADFI in Phase 2.	Zinc	7-9	ADG	Sus scrofa	34-37
14552375-15	2003	Excess Zn decreased (P &lt; 0.09) ADG in Phase 1 but increased (P &lt; 0.09) ADG and ADFI in Phase 2.	Zinc	7-9	ADG	Sus scrofa	77-80
14552375-21	2003	Excess Zn increased (P &lt; 0.07) ADG and ADFI during Phases 2 and 3 and overall.	Zinc	7-9	ADG	Sus scrofa	34-37
12932716-5	2003	Addition of Zn2+ also improved MRT (&gt;9 fold), AUC/dose (2.5 fold) and Tmax (by a factor of 3) when compared to spray dried pure insulin.	Zinc	12-16	insulin	Canis lupus familiaris	131-138
12963354-7	2003	It showed that ZnMT-3 exists in solution as a dynamic mixture of several metalloforms, where the main metalloform is Zn(7)MT-3 and minor forms are Zn(6)MT-3 and Zn(8)MT-3.	Zinc	117-119	metallothionein 3	Homo sapiens	15-21
12963354-7	2003	It showed that ZnMT-3 exists in solution as a dynamic mixture of several metalloforms, where the main metalloform is Zn(7)MT-3 and minor forms are Zn(6)MT-3 and Zn(8)MT-3.	Zinc	117-119	metallothionein 3	Homo sapiens	15-21
12773538-1	2003	Previously we obtained evidence based on engineering of Zn2+ binding sites that the extracellular parts of transmembrane segment 7 (TM7) and TM8 in the human dopamine transporter are important for transporter function.	Zinc	56-60	tetraspanin 16	Homo sapiens	141-144
12773538-1	2003	Previously we obtained evidence based on engineering of Zn2+ binding sites that the extracellular parts of transmembrane segment 7 (TM7) and TM8 in the human dopamine transporter are important for transporter function.	Zinc	56-60	solute carrier family 6 member 3	Homo sapiens	158-178
12935102-0	2003	Novel in-gap spin state in Zn-doped La1.85Sr0.15CuO4.	Zinc	27-29	spindlin 1	Homo sapiens	13-17
12854532-10	2003	Exposure to Zn + Cu resulted in significantly greater epithelial toxicity and stress (c-Jun N-terminal protein kinase activation) responses than did exposure to Zn or Cu individually.	Zinc	12-14	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-91
12763661-3	2003	In the absence of Marimastat, Zn(II) and Fe(II) significantly inhibited MMP-9 activity at metal ion concentrations of 10 and 100 microM, respectively.	Zinc	30-36	matrix metallopeptidase 9	Homo sapiens	72-77
12745081-4	2003	DDP coordinates Zn(2+), and Zn(2+) was found to stimulate the DDP-STAM1 interaction in vitro.	Zinc	28-30	signal transducing adaptor molecule	Homo sapiens	66-71
12744347-3	2003	15N NMR spectra suggest that pentazole, HN5, was also produced and held in solution as N5- with Zn2+ ion.	Zinc	96-100	MT-RNR2 like 5 (pseudogene)	Homo sapiens	40-43
12659878-4	2003	Mg(2+), Co(2+), Ni(2+), Zn(2+), and Ba(2+) had similar effects on U23, U38, and U40, but the mobility of U25 was markedly increased.	Zinc	24-30	small nucleolar RNA, H/ACA box 75	Homo sapiens	66-69
12659878-4	2003	Mg(2+), Co(2+), Ni(2+), Zn(2+), and Ba(2+) had similar effects on U23, U38, and U40, but the mobility of U25 was markedly increased.	Zinc	24-30	small nucleolar RNA, C/D box 46	Homo sapiens	80-83
12926398-8	2003	Likewise the syn- and anti-dizinc(II) bis(2,3-capped porphyrins), 9 and 10, respectively, are synthesised from the related zinc(II) capped porphyrin-2,3-dione 7, and were also identified using molecular recognition studies.	Zinc	29-37	synemin	Homo sapiens	13-16
12721403-8	2003	Zn had no affect on triokinase activity but inhibited the two other enzymes in a dose-dependent manner, with the inhibition of aldolase-B being much greater than of fructokinase for concentrations of Zn between 2.5 and 20 microM.	Zinc	0-2	aldolase, fructose-bisphosphate B	Rattus norvegicus	127-137
12721403-8	2003	Zn had no affect on triokinase activity but inhibited the two other enzymes in a dose-dependent manner, with the inhibition of aldolase-B being much greater than of fructokinase for concentrations of Zn between 2.5 and 20 microM.	Zinc	200-202	aldolase, fructose-bisphosphate B	Rattus norvegicus	127-137
12721403-9	2003	Zn increased the intracellular concentration of fructose-1-P in hepatocytes incubated with fructose, indicating a more potent Zn inhibition of aldolase-B than fructokinase.	Zinc	0-2	aldolase, fructose-bisphosphate B	Rattus norvegicus	143-153
12721403-9	2003	Zn increased the intracellular concentration of fructose-1-P in hepatocytes incubated with fructose, indicating a more potent Zn inhibition of aldolase-B than fructokinase.	Zinc	126-128	aldolase, fructose-bisphosphate B	Rattus norvegicus	143-153
12611518-3	2003	It was found that the natural HgS crystals had activity higher than those of synthesized ones but lower than those of other sulfides of transition metals, e.g., CdS and ZnS, belonging to the same II-IV chalcogenides.	Zinc	169-172	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	30-33
12409304-0	2003	Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor.	Zinc	49-53	adrenoceptor beta 2	Homo sapiens	61-86
12409304-5	2003	We have previously reported that Zn(II) acts as a positive allosteric modulator of the beta(2)-adrenergic receptor (beta(2)AR).	Zinc	33-39	adrenoceptor beta 2	Homo sapiens	87-114
12409304-5	2003	We have previously reported that Zn(II) acts as a positive allosteric modulator of the beta(2)-adrenergic receptor (beta(2)AR).	Zinc	33-39	adrenoceptor beta 2	Homo sapiens	116-125
12409304-6	2003	To identify the Zn(2+) binding site responsible for the enhancement of agonist affinity in the beta(2)AR, we mutated histidines located in hydrophilic sequences bridging the seven transmembrane domains.	Zinc	16-22	adrenoceptor beta 2	Homo sapiens	95-104
12409304-10	2003	Our results suggest that bridging of the cytoplasmic extensions of TM5 and TM6 by Zn(2+) facilitates agonist binding.	Zinc	82-84	tropomyosin 3	Homo sapiens	67-70
12518234-3	2003	The results showed that the deletion of PHO85 or PHO80 gene both increased sensibility of Sacchromyces cerevisiae to ions K(+), Mg(2+), Zn(2+), Ca(2+) and Mn(2+), while the deletion of pap1(pcl-7) gene did not lead to such phenotype.	Zinc	136-138	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	40-45
12513174-1	2002	Recent STM experiments on Bi2Sr2Ca2Cu3O10 observed sharp bound states associated with Zn and Ni impurities, as previously predicted theoretically.	Zinc	86-88	sulfotransferase family 1A member 3	Homo sapiens	7-10
12401084-1	2002	The Fe(II) of the binuclear Fe(II)Fe(III) active site of pig purple acid phosphatase (uteroferrin) has been replaced in turn by five M(II) ions (Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)).	Zinc	181-187	acid phosphatase 5, tartrate resistant	Sus scrofa	86-97
12204890-6	2002	Second, ZN and ZL OVA-treated mice had significant decreases in airway epithelial Zinquin fluorescence, indicating a lowered availability of Zn compared with their SAL-treated counterparts.	Zinc	8-10	satin-like	Mus musculus	164-167
12204890-7	2002	In contrast, the pro-apoptotic protein caspase-3, which was co-localized with Zn in the apical epithelium, was significantly increased in both ZN and ZL OVA-treated mice.	Zinc	78-80	caspase 3	Mus musculus	39-48
12204890-7	2002	In contrast, the pro-apoptotic protein caspase-3, which was co-localized with Zn in the apical epithelium, was significantly increased in both ZN and ZL OVA-treated mice.	Zinc	143-145	caspase 3	Mus musculus	39-48
12149014-2	2002	We consider the recognition of the Zn(II) complex of the bis-tetraazamacrocycle xylyl-bicyclam, a potent anti-HIV agent, by the coreceptor CXCR4, a G-protein-coupled receptor used by HIV for membrane fusion and cell entry.	Zinc	35-41	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
12149014-7	2002	Molecular modeling shows that an analogous cis-V site can be formed when Zn(II)(2)-xylyl-bicyclam binds to CXCR4, involving the carboxylate groups of Asp262 (Zn(II) coordination) and Glu288 (double H-bonding).	Zinc	73-76	C-X-C motif chemokine receptor 4	Homo sapiens	107-112
12149014-7	2002	Molecular modeling shows that an analogous cis-V site can be formed when Zn(II)(2)-xylyl-bicyclam binds to CXCR4, involving the carboxylate groups of Asp262 (Zn(II) coordination) and Glu288 (double H-bonding).	Zinc	73-75	C-X-C motif chemokine receptor 4	Homo sapiens	107-112
12135746-0	2002	Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.	Zinc	0-6	solute carrier family 6 member 3	Homo sapiens	59-79
12135746-3	2002	Here we demonstrate the engineering of a Zn(2+) binding site at the predicted dimeric interface of the dopamine transporter (DAT) corresponding to the external end of transmembrane segment 6.	Zinc	41-47	solute carrier family 6 member 3	Homo sapiens	103-123
12135746-3	2002	Here we demonstrate the engineering of a Zn(2+) binding site at the predicted dimeric interface of the dopamine transporter (DAT) corresponding to the external end of transmembrane segment 6.	Zinc	41-47	solute carrier family 6 member 3	Homo sapiens	125-128
12135746-4	2002	Upon binding to this site, which involves a histidine inserted in position 310 (V310H) and the endogenous Cys306 within the same DAT molecule, Zn(2+) potently inhibits [(3)H]dopamine uptake.	Zinc	143-145	solute carrier family 6 member 3	Homo sapiens	129-132
11940571-1	2002	The human dopamine transporter (hDAT) contains an endogenous high affinity Zn2+ binding site with three coordinating residues on its extracellular face (His193, His375, and Glu396).	Zinc	75-79	solute carrier family 6 member 3	Homo sapiens	10-30
12181895-3	2002	Exotic Zn and Cd made the most contribution to the plant, while the path chain coefficients of CAB-Zn, MnO-Zn, and Cd to the plant by indirect action of exchangeable forms were 0.856, 0.592, 0.723, respectively, showing that they may make some other contributions to tissue Zn and Cd through exchangeable forms.	Zinc	7-9	neural proliferation, differentiation and control 1	Homo sapiens	95-98
12181895-3	2002	Exotic Zn and Cd made the most contribution to the plant, while the path chain coefficients of CAB-Zn, MnO-Zn, and Cd to the plant by indirect action of exchangeable forms were 0.856, 0.592, 0.723, respectively, showing that they may make some other contributions to tissue Zn and Cd through exchangeable forms.	Zinc	99-101	neural proliferation, differentiation and control 1	Homo sapiens	95-98
12181895-3	2002	Exotic Zn and Cd made the most contribution to the plant, while the path chain coefficients of CAB-Zn, MnO-Zn, and Cd to the plant by indirect action of exchangeable forms were 0.856, 0.592, 0.723, respectively, showing that they may make some other contributions to tissue Zn and Cd through exchangeable forms.	Zinc	99-101	neural proliferation, differentiation and control 1	Homo sapiens	95-98
11931693-7	2002	(3) Hexadecylphosphocholine as well as some ions like Zn2+ and PO3-4 could inhibit the activity of CCTbeta, dCTP was another adaptive substrate of CCTbeta besides CTP.	Zinc	54-58	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	99-106
11931693-7	2002	(3) Hexadecylphosphocholine as well as some ions like Zn2+ and PO3-4 could inhibit the activity of CCTbeta, dCTP was another adaptive substrate of CCTbeta besides CTP.	Zinc	54-58	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	147-154
12076317-7	2002	Moreover, delta-aminolevulinate dehydratase from a plant source was inhibited by the selenoxide, suggesting a possible involvement of -SH groups located at a site distinct from the region implicated in Zn2+ binding in mammalian delta-aminolevulinate dehydratase.	Zinc	202-206	aminolevulinate dehydratase	Homo sapiens	10-43
11886258-3	2002	The divalent cation requirement for this activity of e sigma A was further examined by the addition of Mn(2+), Mg(2+), Ca(2+), and Zn(2+) ions.	Zinc	131-133	sigma-A protein	Avian orthoreovirus	55-62
11886258-6	2002	However, Zn(2+) ion inhibited this activity of e sigma A.	Zinc	9-11	sigma-A protein	Avian orthoreovirus	49-56
11818545-0	2002	Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.	Zinc	28-34	solute carrier family 6 member 3	Homo sapiens	49-69
11818545-1	2002	Binding of Zn(2+) to the endogenous Zn(2+) binding site in the human dopamine transporter leads to potent inhibition of [(3)H]dopamine uptake.	Zinc	11-14	solute carrier family 6 member 3	Homo sapiens	69-89
11818545-1	2002	Binding of Zn(2+) to the endogenous Zn(2+) binding site in the human dopamine transporter leads to potent inhibition of [(3)H]dopamine uptake.	Zinc	11-17	solute carrier family 6 member 3	Homo sapiens	69-89
11696542-5	2002	In the presence of high molecular weight kininogen (45 nm), Zn(2+) and Ca(2+) ions, thrombin activated factor XI in the presence of glycocalicin at rates comparable with those seen in the presence of dextran sulfate (1 microg/ml).	Zinc	60-62	coagulation factor II, thrombin	Bos taurus	84-92
11752207-0	2002	Allosteric modulation of beta2-adrenergic receptor by Zn(2+).	Zinc	54-56	adrenoceptor beta 2	Homo sapiens	25-50
11752207-4	2002	We characterized the effect of Zn(2+) on the functional properties of the beta2-adrenergic receptor (beta2AR).	Zinc	31-33	adrenoceptor beta 2	Homo sapiens	74-99
11752207-4	2002	We characterized the effect of Zn(2+) on the functional properties of the beta2-adrenergic receptor (beta2AR).	Zinc	31-33	adrenoceptor beta 2	Homo sapiens	101-108
11752207-5	2002	We found that physiological concentrations of Zn(2+) increased agonist affinity and enhanced cAMP accumulation stimulated by submaximal concentrations of the betaAR agonist isoproterenol.	Zinc	46-52	adrenoceptor beta 2	Homo sapiens	158-164
11570886-3	2001	The recoveries of the enzyme activities by the addition of various metal ions to apo-DPP III were also measured, and Co(2+), Ni(2+), and Cu(2+) ions completely recovered the enzyme activities as did Zn(2+).	Zinc	199-201	dipeptidylpeptidase 3	Rattus norvegicus	85-92
11468394-8	2001	Despite the close structural similarity of the catalytic site to a number of Zn enzymes, these data suggest that Zn, if it binds at the catalytic copper site, binds weakly in nitrite reductase.	Zinc	77-79	nitrite reductase large subunit	Achromobacter xylosoxidans	175-192
11468394-8	2001	Despite the close structural similarity of the catalytic site to a number of Zn enzymes, these data suggest that Zn, if it binds at the catalytic copper site, binds weakly in nitrite reductase.	Zinc	113-115	nitrite reductase large subunit	Achromobacter xylosoxidans	175-192
11344164-8	2001	Finally, we have used Zn(2+) treatment as a maneuver able to discriminate between these two homologues of hTASK and show that the most likely candidate channel for O(2) sensing in these cells is hTASK3.	Zinc	22-28	potassium two pore domain channel subfamily K member 9	Homo sapiens	195-201
11330996-6	2001	Here we compare thermodynamic parameters for the binding of Zn(II), Cu(II), and Co(II) to human carbonic anhydrase II.	Zinc	60-66	carbonic anhydrase 2	Homo sapiens	96-117
11306679-4	2001	We here report that Zn(2+) induced stimulation of the c-Jun N-terminal kinase (JNK) pathway in mouse primary cortical cells and in various cell lines.	Zinc	20-22	mitogen-activated protein kinase 8	Mus musculus	54-77
11306679-4	2001	We here report that Zn(2+) induced stimulation of the c-Jun N-terminal kinase (JNK) pathway in mouse primary cortical cells and in various cell lines.	Zinc	20-22	mitogen-activated protein kinase 8	Mus musculus	79-82
11306679-7	2001	Furthermore, overexpression of Rac1N17, a dominant negative mutant of Rac1, suppressed the Zn(2+)- and PI3Kgamma-induced JNK stimulation.	Zinc	91-93	Rac family small GTPase 1	Homo sapiens	31-35
11306679-9	2001	Taken together, our data suggest that Zn(2+) induces stimulation of the JNK signaling pathway through PI3K-Rac1 signals and that the free-radical generation may be an important step in the Zn(2+) induction of the JNK stimulation.	Zinc	38-44	Rac family small GTPase 1	Homo sapiens	107-111
11358327-0	2001	Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites.	Zinc	101-105	solute carrier family 6 member 3	Homo sapiens	52-72
11358327-3	2001	In this report, we provide the first crude insight into the structural organization of the human dopamine transporter (hDAT) based on the identification of an endogenous high affinity Zn2+ binding site followed by engineering of an artificial Zn2+ binding site.	Zinc	184-188	solute carrier family 6 member 3	Homo sapiens	97-117
11358327-3	2001	In this report, we provide the first crude insight into the structural organization of the human dopamine transporter (hDAT) based on the identification of an endogenous high affinity Zn2+ binding site followed by engineering of an artificial Zn2+ binding site.	Zinc	243-247	solute carrier family 6 member 3	Homo sapiens	97-117
11358327-5	2001	Systematic mutagenesis of potential Zn2+ coordinating residues lead to the identification of three residues on the predicted extracellular face of the transporter, 193His in the second extracellular loop, 375His at the external end of the putative transmembrane segment (TM) 7, and 396Glu at the external end of TM 8, forming three coordinates in the endogenous Zn2+ binding site.	Zinc	36-40	tetraspanin 16	Homo sapiens	312-316
11358327-7	2001	Finally, an artificial inhibitory Zn2+ binding site was engineered between TM 7 and TM 8.	Zinc	34-38	tetraspanin 16	Homo sapiens	84-88
11300894-7	2001	Although the chelation-controlled reduction of 22 should afford the desired anti alcohol 24, Zn(BH(4))(2) at &lt;-90 degrees C gave a 2 approximately 1:1 mixture of anti/syn alcohols.	Zinc	93-95	synemin	Homo sapiens	170-173
11237855-4	2001	We used Xenopus oocytes to demonstrate that, like Nramp2, Nramp1 is a bivalent cation (Fe2+, Zn2+ and Mn2+) transporter.	Zinc	93-97	solute carrier family 11 member 2 L homeolog	Xenopus laevis	50-56
11275419-8	2001	Moreover, delta-ALA-D from a plant source was inhibited by the selenoxides, suggesting a possible involvement of SH groups in a distinct site of the homologous region implicated in Zn2+ binding in mammalian delta-ALA-D.	Zinc	181-185	aminolevulinate dehydratase	Homo sapiens	10-21
11275419-8	2001	Moreover, delta-ALA-D from a plant source was inhibited by the selenoxides, suggesting a possible involvement of SH groups in a distinct site of the homologous region implicated in Zn2+ binding in mammalian delta-ALA-D.	Zinc	181-185	aminolevulinate dehydratase	Homo sapiens	207-218
11172685-7	2001	Using an in vitro spectrophotometric technique, the Zn(++) reactivity of several CMTs was assessed and found to be positively related to the potency of these compounds as MMP inhibitors.	Zinc	52-58	matrix metallopeptidase 9	Rattus norvegicus	171-174
11170541-7	2001	Li/Mg atoms (A sites) fill cavities within the Al/Zn network to give pentagonal dodecahedra (A20).	Zinc	50-52	immunoglobulin kappa variable 1-27	Homo sapiens	93-96
11160420-5	2001	Mutation of these redox-sensitive cysteine residues also affects high-affinity, voltage-independent Zn(2+) inhibition that is specific to NR1/NR2A receptors.	Zinc	100-102	glutamate receptor ionotropic, NMDA 2A-like	Xenopus laevis	142-146