PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31340742-1	2020	OBJECTIVE: The aim of this study was to investigate the association of sex hormone binding globulin (SHBG) with leptin, triiodothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal resting energy expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.	Triiodothyronine	120-136	sex hormone binding globulin	Homo sapiens	71-99
31340742-1	2020	OBJECTIVE: The aim of this study was to investigate the association of sex hormone binding globulin (SHBG) with leptin, triiodothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal resting energy expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.	Triiodothyronine	120-136	sex hormone binding globulin	Homo sapiens	101-105
31340742-1	2020	OBJECTIVE: The aim of this study was to investigate the association of sex hormone binding globulin (SHBG) with leptin, triiodothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal resting energy expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.	Triiodothyronine	138-140	sex hormone binding globulin	Homo sapiens	71-99
31340742-1	2020	OBJECTIVE: The aim of this study was to investigate the association of sex hormone binding globulin (SHBG) with leptin, triiodothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal resting energy expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.	Triiodothyronine	138-140	sex hormone binding globulin	Homo sapiens	101-105
31340742-11	2020	CONCLUSION: Changes of the UCP2, leptin, and thyroid hormone (T3) levels may be related to SHBG levels.	Triiodothyronine	62-64	sex hormone binding globulin	Homo sapiens	91-95
31585886-5	2020	Moreover, there is a growing interest in understanding the possible role of polymorphisms of DIO1 and DIO2 genes in some pathological conditions and in determining the requirement of levothyroxine replacement and the role of combined levothyroxine-liothyronine therapy in carrying subjects affected by hypothyroidism and who need replacement therapy.	Triiodothyronine	234-260	iodothyronine deiodinase 1	Homo sapiens	93-97
31571530-1	2019	Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to cause beneficial health effects, including reversal of steatohepatosis and prevention of insulin resistance, in most instances without adverse thyrotoxic side effects.	Triiodothyronine	182-201	insulin	Homo sapiens	313-320
31514184-9	2020	The application of T3 prior to H/R injury significantly decreased the increased INaL, INaT, and reverse-INCX and blunted the [Ca2+]i increase.	Triiodothyronine	19-21	phospholipase A and acyltransferase 5	Mus musculus	86-90
31714064-3	2019	Tetraiodothyroacetic acid (tetrac), a deaminated derivative of l-thyroxine (T4), is a "thyrointegrin" antagonist that blocks the actions of l-triiodothyronine (T3) and T4 with an interaction site that is located at or near the RGD recognition site identified on integrin alphavbeta3"s binding pocket (thyrointegrin alphavbeta3 receptors).	Triiodothyronine	160-162	integrin subunit alpha V	Homo sapiens	262-282
31817347-6	2019	Therefore, in this study, we investigate the expression of ANP in beige-like adipocytes induced by docosahexaenoic acids (DHA), T3, or a PPAR agonist, rosiglitazone.	Triiodothyronine	128-130	natriuretic peptide A	Homo sapiens	59-62
31809508-1	2019	Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine.	Triiodothyronine	119-135	solute carrier family 16 member 2	Homo sapiens	54-58
31817149-2	2019	Herein, we demonstrate that during murine muscle satellite cell and myoblast differentiation, transthyretin (TTR) can exocytose via exosomes and enter cells as TTR- thyroxine (T4) complex, which consecutively induces the intracellular triiodothyronine (T3) level, followed by T3 secretion out of the cell through the exosomes.	Triiodothyronine	235-251	transthyretin	Mus musculus	94-107
31817149-2	2019	Herein, we demonstrate that during murine muscle satellite cell and myoblast differentiation, transthyretin (TTR) can exocytose via exosomes and enter cells as TTR- thyroxine (T4) complex, which consecutively induces the intracellular triiodothyronine (T3) level, followed by T3 secretion out of the cell through the exosomes.	Triiodothyronine	235-251	transthyretin	Mus musculus	109-112
31817149-2	2019	Herein, we demonstrate that during murine muscle satellite cell and myoblast differentiation, transthyretin (TTR) can exocytose via exosomes and enter cells as TTR- thyroxine (T4) complex, which consecutively induces the intracellular triiodothyronine (T3) level, followed by T3 secretion out of the cell through the exosomes.	Triiodothyronine	235-251	transthyretin	Mus musculus	160-163
31056723-12	2019	Mitogen-stimulated T cells from hypothyroid mice showed impaired proliferation, accompanied by decreased activation of PKC and lower levels of p-ERK, effects that were reversed by T3 replacement or zinc supplementation.	Triiodothyronine	180-182	mitogen-activated protein kinase 1	Mus musculus	145-148
30244055-1	2019	Thyroid hormones (THs) stimulate and coordinate a wide range of processes to ensure normal development, mainly by binding of the most active TH 3,5,3"-triiodothyronine (T3) to nuclear receptors resulting in changes in gene transcription.	Triiodothyronine	169-171	tyrosine hydroxylase	Danio rerio	18-20
31614708-2	2019	Hormones, like insulin, triiodothyronine (T3), and angiotensin II (Ang II), can regulate gene-splicing through RBM20, but the detailed mechanism remains unclear.	Triiodothyronine	24-40	RNA binding motif protein 20	Rattus norvegicus	111-116
31600974-3	2019	3,3,5-Triiodo-L-thyronine (T3) can interact with nuclear thyroid hormone receptors (TR) to modulate transcriptional activities via thyroid hormone response elements (TRE) in the regulatory regions of target genes or bind receptor molecules showing no structural homology to TRs, such as the cell surface receptor site on integrin alphavbeta3.	Triiodothyronine	0-25	CD177 molecule	Homo sapiens	291-312
31600974-3	2019	3,3,5-Triiodo-L-thyronine (T3) can interact with nuclear thyroid hormone receptors (TR) to modulate transcriptional activities via thyroid hormone response elements (TRE) in the regulatory regions of target genes or bind receptor molecules showing no structural homology to TRs, such as the cell surface receptor site on integrin alphavbeta3.	Triiodothyronine	0-25	integrin subunit alpha V	Homo sapiens	321-341
31600974-3	2019	3,3,5-Triiodo-L-thyronine (T3) can interact with nuclear thyroid hormone receptors (TR) to modulate transcriptional activities via thyroid hormone response elements (TRE) in the regulatory regions of target genes or bind receptor molecules showing no structural homology to TRs, such as the cell surface receptor site on integrin alphavbeta3.	Triiodothyronine	27-29	CD177 molecule	Homo sapiens	291-312
31600974-3	2019	3,3,5-Triiodo-L-thyronine (T3) can interact with nuclear thyroid hormone receptors (TR) to modulate transcriptional activities via thyroid hormone response elements (TRE) in the regulatory regions of target genes or bind receptor molecules showing no structural homology to TRs, such as the cell surface receptor site on integrin alphavbeta3.	Triiodothyronine	27-29	integrin subunit alpha V	Homo sapiens	321-341
31617166-10	2019	One hypothesis is that a SNP (Thr92Ala) in DIO2 (required for local production of T3 out of T4) interferes with its kinetics and/or action, resulting in a local hypothyroid state in the brain.	Triiodothyronine	82-84	iodothyronine deiodinase 2	Homo sapiens	43-47
31300610-0	2019	Triiodothyronine Reduces Vascular Dysfunction Associated with Hypertension by Attenuating Protein Kinase G/Vasodilator-Stimulated Phosphoprotein Signaling.	Triiodothyronine	0-16	vasodilator-stimulated phosphoprotein	Rattus norvegicus	107-144
31534055-7	2019	Strikingly, T3 treatment reduced TRalpha1 and DIO3 expression and completely reversed all these alterations.	Triiodothyronine	12-14	phospholipid scramblase 4	Homo sapiens	33-41
31410155-2	2019	We previously reported that the expression of osteocalcin is stimulated by triiodothyronine (T3) at least in part through the activation of p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	75-91	bone gamma-carboxyglutamate protein 2	Mus musculus	46-57
31410155-2	2019	We previously reported that the expression of osteocalcin is stimulated by triiodothyronine (T3) at least in part through the activation of p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	75-91	mitogen-activated protein kinase 14	Mus musculus	140-143
31410155-2	2019	We previously reported that the expression of osteocalcin is stimulated by triiodothyronine (T3) at least in part through the activation of p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	93-95	bone gamma-carboxyglutamate protein 2	Mus musculus	46-57
31410155-2	2019	We previously reported that the expression of osteocalcin is stimulated by triiodothyronine (T3) at least in part through the activation of p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	93-95	mitogen-activated protein kinase 14	Mus musculus	140-143
31194990-1	2019	Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa beta (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts.	Triiodothyronine	0-16	TNF superfamily member 11	Homo sapiens	162-167
31194990-1	2019	Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa beta (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts.	Triiodothyronine	0-16	TNF receptor superfamily member 11b	Homo sapiens	173-188
31194990-1	2019	Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa beta (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts.	Triiodothyronine	0-16	TNF receptor superfamily member 11b	Homo sapiens	190-193
31726548-8	2019	Serum levels of total T4 and total 3,3",5-triiodo-L-thyronine (T3) in PCB-exposed dogs were lower than in the control group at 24 and 48 h and negatively correlated with PCB concentrations, implying that PCB exposure enhanced TH excretion by increasing TH uptake and TH conjugation enzyme activities in the dog liver.	Triiodothyronine	63-65	tyrosine hydroxylase	Canis lupus familiaris	226-228
31726548-8	2019	Serum levels of total T4 and total 3,3",5-triiodo-L-thyronine (T3) in PCB-exposed dogs were lower than in the control group at 24 and 48 h and negatively correlated with PCB concentrations, implying that PCB exposure enhanced TH excretion by increasing TH uptake and TH conjugation enzyme activities in the dog liver.	Triiodothyronine	63-65	tyrosine hydroxylase	Canis lupus familiaris	253-255
31726548-8	2019	Serum levels of total T4 and total 3,3",5-triiodo-L-thyronine (T3) in PCB-exposed dogs were lower than in the control group at 24 and 48 h and negatively correlated with PCB concentrations, implying that PCB exposure enhanced TH excretion by increasing TH uptake and TH conjugation enzyme activities in the dog liver.	Triiodothyronine	63-65	tyrosine hydroxylase	Canis lupus familiaris	253-255
31095291-10	2019	Kruppel-like factor 9 (KLF9), a multifunctional transcription factor that plays a key role in central nervous system development, was highly upregulated by T3 treatment in hypoxic conditions.	Triiodothyronine	156-158	Kruppel-like factor 9	Mus musculus	0-21
31095291-10	2019	Kruppel-like factor 9 (KLF9), a multifunctional transcription factor that plays a key role in central nervous system development, was highly upregulated by T3 treatment in hypoxic conditions.	Triiodothyronine	156-158	Kruppel-like factor 9	Mus musculus	23-27
31095291-11	2019	Knockdown of the KLF9 gene resulted in early apoptosis and abolished the beneficial role of T3 in neuronal survival.	Triiodothyronine	92-94	Kruppel-like factor 9	Mus musculus	17-21
31095291-12	2019	KLF9 mediates, in part, the neuronal protective role of T3.	Triiodothyronine	56-58	Kruppel-like factor 9	Mus musculus	0-4
31507530-1	2019	Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin alphavbeta3.	Triiodothyronine	165-182	integrin subunit alpha V	Homo sapiens	186-206
31071665-7	2019	Importantly, we found that both extracts and polar fractions of SRM activated TRalpha and significantly potentiated the activity of endogenous TRalpha ligand, triiodothyronine.	Triiodothyronine	159-175	T cell receptor alpha locus	Homo sapiens	143-150
31264512-6	2019	Methods: Thyrotoxicosis was induced in 120-day-old female and male mice with beta2-AR gene inactivation (beta2-AR-/-) by daily treatment with supraphysiological doses of triiodothyronine (T3) for 12 weeks.	Triiodothyronine	170-186	adenosine A2a receptor	Mus musculus	77-85
31264512-6	2019	Methods: Thyrotoxicosis was induced in 120-day-old female and male mice with beta2-AR gene inactivation (beta2-AR-/-) by daily treatment with supraphysiological doses of triiodothyronine (T3) for 12 weeks.	Triiodothyronine	170-186	adenosine A2a receptor	Mus musculus	105-113
31264512-10	2019	T3 treatment increased the femoral RANKL/OPG mRNA ratio and the endosteal perimeter and medullary area of the diaphysis in WT females and males, but not in beta2-AR-/- mice, suggesting that T3 promotes endosteal resorption in cortical bone, in a mechanism that involves beta2-AR signaling.	Triiodothyronine	0-2	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	35-40
31264512-10	2019	T3 treatment increased the femoral RANKL/OPG mRNA ratio and the endosteal perimeter and medullary area of the diaphysis in WT females and males, but not in beta2-AR-/- mice, suggesting that T3 promotes endosteal resorption in cortical bone, in a mechanism that involves beta2-AR signaling.	Triiodothyronine	0-2	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	41-44
31264512-10	2019	T3 treatment increased the femoral RANKL/OPG mRNA ratio and the endosteal perimeter and medullary area of the diaphysis in WT females and males, but not in beta2-AR-/- mice, suggesting that T3 promotes endosteal resorption in cortical bone, in a mechanism that involves beta2-AR signaling.	Triiodothyronine	0-2	adenosine A2a receptor	Mus musculus	270-278
31264512-11	2019	T3 treatment increased endocortical mineral apposition rate only in WT females but not in beta2-AR-/- mice, suggesting that TH also induce bone formation in a beta2-AR signaling-dependent mechanism.	Triiodothyronine	0-2	adenosine A2a receptor	Mus musculus	159-167
31264512-14	2019	Conclusions: These findings sustain the hypothesis that T3 interacts with the SNS to regulate bone morphophysiology in a beta2-AR signaling-dependent mechanism.	Triiodothyronine	56-58	adenosine A2a receptor	Mus musculus	121-129
30747412-7	2019	In conclusion, THRA gene mutation should be considered in patients with clinical hypothyroid findings and increased/moderately elevated free T3, decreased/ normal free thyroxine, normal thyroid-stimulating hormone levels, and increased muscle enzymes.	Triiodothyronine	141-143	thyroid hormone receptor alpha	Homo sapiens	15-19
31211688-11	2019	A significant negative correlation was observed between free tri-iodothyronine (fT3) and both FGF-23 and alpha-klotho in the obese group.	Triiodothyronine	61-78	fibroblast growth factor 23	Homo sapiens	94-100
31380419-9	2019	Angptl8 was positively correlated with triglyceride (r = 0.267, p = 0.012) and cholesterol levels (r= 0.235, p = 0.028) but was negatively correlated with tri-iodothyronine (r = -0.24, p = 0.031).	Triiodothyronine	155-172	angiopoietin like 8	Homo sapiens	0-7
30900216-8	2019	Serum ANGPTL8 was negatively correlated with free triiodothyronine (FT3), free thyroxine (FT4), and thyroid peroxidase antibodies (TPOAb) while being positively correlated with thyrotropin (TSH).	Triiodothyronine	50-66	angiopoietin like 8	Homo sapiens	6-13
31051388-0	2019	Thyroid hormone (T3) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.	Triiodothyronine	17-19	AKT serine/threonine kinase 1	Bos taurus	108-111
31051388-9	2019	We concluded that T3 inhibited newborn calf SCs proliferation through the PI3K/Akt signaling pathway and possibly promoted their differentiation.	Triiodothyronine	18-20	AKT serine/threonine kinase 1	Bos taurus	79-82
31194638-7	2019	Serum TSHR autoantibody concentrations reduced during the study and correlated with changes in free thyroid hormones (r = 0.85, p = 0.002 for TSHR autoantibody vs. free triiodothyronine).	Triiodothyronine	169-185	thyroid stimulating hormone receptor	Homo sapiens	6-10
31024454-1	2019	This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3"-triiodo-L-thyronine (T3) on rat liver mitochondrial DNA (mtDNA) oxidative damage and repair and to investigate their ability to induce protective effects against oxidative stress.	Triiodothyronine	67-93	neurotrophin 3	Rattus norvegicus	95-97
30714146-5	2019	Moreover, by using genetic and pharmacological approaches to manipulate both local and systemic levels of thyroid hormones, we showed that T3 was required to promote proliferation of pancreatic acinar cells, without affecting the extent of tissue damage or inflammatory infiltration.Finally, upon genetic and pharmacological inactivation of selected signalling pathways, we demonstrated that T3 exerted its mitogenic effect on acinar cells via a tightly controlled action on different molecular effectors, including histone deacetylase, AKT, and TGFbeta signalling.In conclusion, our data suggest that local availability of T3 in the pancreas is required to promote acinar cell proliferation and provide the rationale to exploit thyroid hormone signalling to enhance pancreatic regeneration.	Triiodothyronine	139-141	AKT serine/threonine kinase 1	Homo sapiens	537-540
30714146-5	2019	Moreover, by using genetic and pharmacological approaches to manipulate both local and systemic levels of thyroid hormones, we showed that T3 was required to promote proliferation of pancreatic acinar cells, without affecting the extent of tissue damage or inflammatory infiltration.Finally, upon genetic and pharmacological inactivation of selected signalling pathways, we demonstrated that T3 exerted its mitogenic effect on acinar cells via a tightly controlled action on different molecular effectors, including histone deacetylase, AKT, and TGFbeta signalling.In conclusion, our data suggest that local availability of T3 in the pancreas is required to promote acinar cell proliferation and provide the rationale to exploit thyroid hormone signalling to enhance pancreatic regeneration.	Triiodothyronine	139-141	transforming growth factor alpha	Homo sapiens	546-553
30760120-2	2019	In the absence of triiodothyronine (T3), TRalpha interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repression.	Triiodothyronine	36-38	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	41-48
30760120-2	2019	In the absence of triiodothyronine (T3), TRalpha interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repression.	Triiodothyronine	36-38	nuclear receptor co-repressor 1	Mus musculus	89-120
30760120-2	2019	In the absence of triiodothyronine (T3), TRalpha interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repression.	Triiodothyronine	36-38	nuclear receptor co-repressor 1	Mus musculus	122-127
30722716-8	2019	In the hypothyroidism group, irisin levels were positively associated with free triiodothyronine and free thyroxine levels, and negatively associated with thyrotropin levels.	Triiodothyronine	80-96	fibronectin type III domain containing 5	Homo sapiens	29-35
30916164-0	2019	Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7.	Triiodothyronine	0-16	transforming growth factor alpha	Homo sapiens	67-71
30406874-0	2019	Triiodothyronine Promotes Cell Proliferation of Breast Cancer via Modulating miR-204/Amphiregulin.	Triiodothyronine	0-16	microRNA 204	Homo sapiens	77-84
30406874-0	2019	Triiodothyronine Promotes Cell Proliferation of Breast Cancer via Modulating miR-204/Amphiregulin.	Triiodothyronine	0-16	amphiregulin	Homo sapiens	85-97
30769017-5	2019	Further, cardiac-specific overexpression of Med13 in mice that were treated with propylthiouracil (PTU), an inhibitor of the biosynthesis of the active TH, triiodothyronine (T3), resulted in resistance to PTU-dependent decreases in cardiac contractility.	Triiodothyronine	156-172	mediator complex subunit 13	Mus musculus	44-49
30769017-5	2019	Further, cardiac-specific overexpression of Med13 in mice that were treated with propylthiouracil (PTU), an inhibitor of the biosynthesis of the active TH, triiodothyronine (T3), resulted in resistance to PTU-dependent decreases in cardiac contractility.	Triiodothyronine	174-176	mediator complex subunit 13	Mus musculus	44-49
30578580-1	2019	Docosahexaenoic acid (DHA) and 3,3",5-triiodothyronine (T3 ) combined protocol affords protection against liver injury via AMPK signaling supporting energy requirements.	Triiodothyronine	31-54	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	123-127
30578580-1	2019	Docosahexaenoic acid (DHA) and 3,3",5-triiodothyronine (T3 ) combined protocol affords protection against liver injury via AMPK signaling supporting energy requirements.	Triiodothyronine	56-58	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	123-127
30916164-0	2019	Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7.	Triiodothyronine	18-20	transforming growth factor alpha	Homo sapiens	67-71
30916164-1	2019	OBJECTIVE: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor alpha (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway.	Triiodothyronine	49-65	tumor necrosis factor	Homo sapiens	90-122
30916164-1	2019	OBJECTIVE: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor alpha (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway.	Triiodothyronine	49-65	transforming growth factor alpha	Homo sapiens	124-128
30858725-5	2019	Aim of the present study was to analyze the regulation of TAAR1 in breast cancer cell lines and the influence of triiodothyronine (T3), thyronamines, and tetraiodothyroacetic acid (Tetrac) on the expression of TAAR1 in breast cancer cells.	Triiodothyronine	113-129	trace amine associated receptor 1	Homo sapiens	210-215
30810960-8	2019	This study shows that triiodothyronine (T3) hormone makes some differences in heat capacity upon binding to the THR-beta ligand binding domain (LBD).	Triiodothyronine	22-38	thyroid hormone receptor alpha	Homo sapiens	112-120
30810960-8	2019	This study shows that triiodothyronine (T3) hormone makes some differences in heat capacity upon binding to the THR-beta ligand binding domain (LBD).	Triiodothyronine	40-42	thyroid hormone receptor alpha	Homo sapiens	112-120
30543877-0	2019	Cystatin C in adipose tissue and stimulation of its production by growth hormone and triiodothyronine in 3T3-L1 cells.	Triiodothyronine	85-101	cystatin C	Mus musculus	0-10
30543877-4	2019	As growth hormone (GH) and triiodothyronine (T3) increase both GFR and CysC (increased in acromegaly and hyperthyroidism) in vivo, we studied whether they could increase CysC production in 3T3-L1 adipocytes in vitro.	Triiodothyronine	45-47	cystatin C	Mus musculus	71-75
30543877-4	2019	As growth hormone (GH) and triiodothyronine (T3) increase both GFR and CysC (increased in acromegaly and hyperthyroidism) in vivo, we studied whether they could increase CysC production in 3T3-L1 adipocytes in vitro.	Triiodothyronine	45-47	cystatin C	Mus musculus	170-174
30543877-6	2019	GH and T3 both (10 nmol/l) increased accumulation of CysC, to 373 +- 14 and 422 +- 20, respectively, vs 298 +- 10 ng per well over 4 days in controls.	Triiodothyronine	7-9	cystatin C	Mus musculus	53-57
30543877-7	2019	Thus, GH and T3 enhance the production of CysC by adipocytes in vitro.	Triiodothyronine	13-15	cystatin C	Mus musculus	42-46
30543877-4	2019	As growth hormone (GH) and triiodothyronine (T3) increase both GFR and CysC (increased in acromegaly and hyperthyroidism) in vivo, we studied whether they could increase CysC production in 3T3-L1 adipocytes in vitro.	Triiodothyronine	27-43	cystatin C	Mus musculus	71-75
30369548-3	2019	Nine uncharacterized MCT8 mutations in Japanese patients with severe neurocognitive impairment and elevated serum T3 levels were studied regarding the transport of T3.	Triiodothyronine	114-116	solute carrier family 16 member 2	Homo sapiens	21-25
30891787-0	2019	Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3-L1 Adipocytes.	Triiodothyronine	58-74	thymoma viral proto-oncogene 1	Mus musculus	40-43
30891787-1	2019	Adipose tissue (AT), an endocrine organ that modulates several physiological functions by synthesizing and releasing adipokines such as adiponectin, is a metabolic target of triiodothyronine (T3).	Triiodothyronine	174-190	adiponectin, C1Q and collagen domain containing	Mus musculus	136-147
30891787-1	2019	Adipose tissue (AT), an endocrine organ that modulates several physiological functions by synthesizing and releasing adipokines such as adiponectin, is a metabolic target of triiodothyronine (T3).	Triiodothyronine	192-194	adiponectin, C1Q and collagen domain containing	Mus musculus	136-147
30352046-3	2019	Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) is added to LT4 therapy.	Triiodothyronine	122-134	deiodinase, iodothyronine, type II	Mus musculus	82-86
30545633-1	2019	The thyroid hormone-binding protein mu-crystallin (CRYM) mediates thyroid hormone action by sequestering triiodothyronine in the cytoplasm and regulating the intracellular concentration of thyroid hormone.	Triiodothyronine	105-121	crystallin, mu	Mus musculus	51-55
30545633-2	2019	As thyroid hormone action is closely associated with glycolipid metabolism, it has been proposed that CRYM may contribute to this process by reserving or releasing triiodothyronine in the cytoplasm.	Triiodothyronine	164-180	crystallin, mu	Mus musculus	102-106
30352046-3	2019	Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) is added to LT4 therapy.	Triiodothyronine	136-139	deiodinase, iodothyronine, type II	Mus musculus	82-86
31619646-11	2019	These results suggest that T3 elicits the cytoprotective effects via ERbeta/PI3K/Akt signaling pathway in cellular and murine PD models.	Triiodothyronine	27-29	estrogen receptor 1 (alpha)	Mus musculus	69-75
30209975-0	2019	Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.	Triiodothyronine	17-19	mechanistic target of rapamycin kinase	Mus musculus	97-101
30209975-4	2019	Interestingly, there was no significant induction of intracellular reactive oxygen species (ROS) despite high mitochondrial respiration and UCP1 induction by T3.	Triiodothyronine	158-160	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	140-144
30209975-5	2019	However, when cells were treated with Atg5 siRNA to block autophagy, induction of mitochondrial respiration by T3 decreased, and was accompanied by ROS accumulation, demonstrating a critical role for autophagic mitochondrial turnover.	Triiodothyronine	111-113	autophagy related 5	Mus musculus	38-42
30209975-9	2019	T3 also decreased amino acid levels, and in conjunction with SIRT1 activation, decreased MTOR activity to stimulate autophagy.	Triiodothyronine	0-2	mechanistic target of rapamycin kinase	Mus musculus	89-93
30816679-0	2019	Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses.	Triiodothyronine	27-43	interleukin 17A	Mus musculus	89-94
31155579-2	2019	We focused on the anticancer activity of tocotrienol (T3) and have reported that a new redox-inactive T3 derivative (6-O-carboxypropyl-alpha-tocotrienol; T3E) exerts stronger inhibitory effects on MM cell growth than that of T3 in vitro.	Triiodothyronine	54-56	CD3 antigen, epsilon polypeptide	Mus musculus	154-157
31155579-2	2019	We focused on the anticancer activity of tocotrienol (T3) and have reported that a new redox-inactive T3 derivative (6-O-carboxypropyl-alpha-tocotrienol; T3E) exerts stronger inhibitory effects on MM cell growth than that of T3 in vitro.	Triiodothyronine	102-104	CD3 antigen, epsilon polypeptide	Mus musculus	154-157
31155579-2	2019	We focused on the anticancer activity of tocotrienol (T3) and have reported that a new redox-inactive T3 derivative (6-O-carboxypropyl-alpha-tocotrienol; T3E) exerts stronger inhibitory effects on MM cell growth than that of T3 in vitro.	Triiodothyronine	102-104	CD3 antigen, epsilon polypeptide	Mus musculus	154-157
31155579-7	2019	The area under the plasma T3 and T3E concentration-time curve from 0 to 24 h (AUC0-24 h) of T3E was two times higher than that of T3.	Triiodothyronine	26-28	CD3 antigen, epsilon polypeptide	Mus musculus	92-95
31619646-11	2019	These results suggest that T3 elicits the cytoprotective effects via ERbeta/PI3K/Akt signaling pathway in cellular and murine PD models.	Triiodothyronine	27-29	thymoma viral proto-oncogene 1	Mus musculus	81-84
30235988-11	2018	A strong impairment of T3-binding for TRbeta mutants was shown compared to TRIAC and NH-3 and could explain the different efficiencies of the different ligands in releasing corepressors from the studied TRbeta mutants.	Triiodothyronine	23-25	T cell receptor alpha locus	Homo sapiens	38-44
31084432-7	2019	The results showed that T3 treatment downregulated the exogenous Cathepsin D and Serpine1 proteins but upregulated Profilin-1 protein, which play a key role in breast cancer in the MDA-MB-231 cells.	Triiodothyronine	24-26	cathepsin D	Homo sapiens	65-76
31084432-7	2019	The results showed that T3 treatment downregulated the exogenous Cathepsin D and Serpine1 proteins but upregulated Profilin-1 protein, which play a key role in breast cancer in the MDA-MB-231 cells.	Triiodothyronine	24-26	serpin family E member 1	Homo sapiens	81-89
31084432-7	2019	The results showed that T3 treatment downregulated the exogenous Cathepsin D and Serpine1 proteins but upregulated Profilin-1 protein, which play a key role in breast cancer in the MDA-MB-231 cells.	Triiodothyronine	24-26	profilin 1	Homo sapiens	115-125
30618782-2	2018	As thyroid hormone (3,5,3"-triiodothyronine, T3) plays a critical role in determining the sensitive period of imprinting, we examined if exogenously applied T3 (or iopanoic acid, IOP; a selective inhibitor for converting enzymes) could also sensitize (or desensitize) the BM induction.	Triiodothyronine	20-43	parathyroid hormone	Gallus gallus	3-18
30618782-2	2018	As thyroid hormone (3,5,3"-triiodothyronine, T3) plays a critical role in determining the sensitive period of imprinting, we examined if exogenously applied T3 (or iopanoic acid, IOP; a selective inhibitor for converting enzymes) could also sensitize (or desensitize) the BM induction.	Triiodothyronine	45-47	parathyroid hormone	Gallus gallus	3-18
30031103-0	2018	Posttranscriptional actions of triiodothyronine on Tshb expression in TalphaT1 cells: New insights into molecular mechanisms of negative feedback.	Triiodothyronine	31-47	thyroid stimulating hormone, beta subunit	Mus musculus	51-55
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	T cell receptor beta locus	Homo sapiens	68-74
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	DNL-type zinc finger	Homo sapiens	81-85
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	caspase 3	Homo sapiens	197-206
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	BCL2 antagonist/killer 1	Homo sapiens	212-215
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	BCL2 apoptosis regulator	Homo sapiens	252-257
29679278-6	2018	In the presence of 3,5,3-L-triiodothyronine (T3), the expression of TRbeta in SK-hep1 cells inhibited cancer cell proliferation and impeded tumor cell migration through the up-regulation of 4-1BB, Caspase-3, and Bak gene expression; down-regulation of Bcl-2 gene expression; and activation of the Caspase-3 protein.	Triiodothyronine	45-47	caspase 3	Homo sapiens	297-306
30236902-1	2018	OBJECTIVE: Low tri-iodothyronine (T3) syndrome is a predictor of poor prognosis in patients with stroke.	Triiodothyronine	34-36	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	15-18
30368674-4	2018	The expression of HSP60, HSP70, HSP90, Bax, Bcl-2, and p53 genes in blood leukocytes, rectal and superficial temperatures, respiratory frequency, cortisol, triiodothyronine, and thyroxine was measured at 06:00, 13:00, and 18:00 h. In vitro, blood leukocytes were subjected to 38  C and 40  C for 3 h to measure the expression of the same target genes.	Triiodothyronine	156-172	cellular tumor antigen p53	Capra hircus	55-58
30235988-11	2018	A strong impairment of T3-binding for TRbeta mutants was shown compared to TRIAC and NH-3 and could explain the different efficiencies of the different ligands in releasing corepressors from the studied TRbeta mutants.	Triiodothyronine	23-25	T cell receptor alpha locus	Homo sapiens	203-209
30362879-3	2018	In silico and in vitro studies confirmed that substituting L341 with valine and other non-polar amino acids impairs sensitivity of TRbeta for triiodothyronine to various degrees, depending on their side-chain size and orientation.	Triiodothyronine	142-158	T cell receptor beta locus	Homo sapiens	131-137
29920214-2	2018	The primary purpose of this study was to examine the effects of triiodothyronine (T3) repletion on energy homeostasis and skeletal muscle physiology in weight-reduced subjects and to compare these results with the effects of leptin repletion.	Triiodothyronine	64-80	solute carrier family 25 member 5	Homo sapiens	82-84
29742907-3	2018	Genomic actions of thyroid hormone as 3,5,3"-triiodo-L-thyronine (T3) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4) on platelet integrin alphavbeta3 are prothrombotic.	Triiodothyronine	66-68	integrin subunit alpha V	Homo sapiens	243-263
30149342-8	2018	BDE-209 in the serum was significantly and positively correlated with total thyroxine (tT4, r = 0.270, p = 0.029) and marginally and positively correlated with total triiodothyronine (tT3, r = 0.232, p = 0.061) in all occupational workers after adjusting for gender, age, BMI, and occupational exposure duration.	Triiodothyronine	166-182	homeobox D13	Homo sapiens	0-3
30574458-1	2018	Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels.	Triiodothyronine	119-135	iodothyronine deiodinase 2	Homo sapiens	12-29
30574458-1	2018	Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels.	Triiodothyronine	119-135	iodothyronine deiodinase 2	Homo sapiens	31-35
30574458-1	2018	Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels.	Triiodothyronine	137-139	iodothyronine deiodinase 2	Homo sapiens	12-29
30574458-1	2018	Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels.	Triiodothyronine	137-139	iodothyronine deiodinase 2	Homo sapiens	31-35
30129879-1	2018	BACKGROUND: 3-Iodothyroacetic acid (TA1) is among the thyroid hormone (T3) metabolites that can acutely modify behavior in mice.	Triiodothyronine	71-73	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	36-39
30063552-3	2018	Whereas the types 1 and 2 deiodinase (D1 and D2) activate thyroxine (T4) to 3,5,3"-triiodothyronine (T3) via deiodination of T4"s outer ring, D1 and D3 inactivate both T4 and T3 and terminate thyroid hormone action via deiodination of T4"s inner molecular ring.	Triiodothyronine	76-99	leiomodin 1	Homo sapiens	38-47
30063552-3	2018	Whereas the types 1 and 2 deiodinase (D1 and D2) activate thyroxine (T4) to 3,5,3"-triiodothyronine (T3) via deiodination of T4"s outer ring, D1 and D3 inactivate both T4 and T3 and terminate thyroid hormone action via deiodination of T4"s inner molecular ring.	Triiodothyronine	101-103	leiomodin 1	Homo sapiens	38-47
30063552-3	2018	Whereas the types 1 and 2 deiodinase (D1 and D2) activate thyroxine (T4) to 3,5,3"-triiodothyronine (T3) via deiodination of T4"s outer ring, D1 and D3 inactivate both T4 and T3 and terminate thyroid hormone action via deiodination of T4"s inner molecular ring.	Triiodothyronine	101-103	leiomodin 1	Homo sapiens	142-151
30056003-1	2018	BACKGROUND: Several studies have shown that high level of plasma C-reactive protein (CRP) is associated with stroke outcomes and future vascular events, and a decrease in serum triiodothyronine (T3) was reported to be associated with stroke severity and poor prognosis.	Triiodothyronine	195-197	C-reactive protein	Homo sapiens	85-88
30233497-2	2018	Hypercholesterolemia in hypothyroidism is mainly due to a reduction in low-density lipoprotein (LDL) receptor activity, this accompanied by concomitant diminishing control by triiodothyronine (T3) of sterol regulatory element-binding protein 2 (SREBP-2), which modulates cholesterol biosynthesis by regulating rate-limit degrading enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) activity.	Triiodothyronine	175-191	sterol regulatory element binding transcription factor 2	Homo sapiens	200-243
30186412-0	2018	Triiodothyronine alleviates alcoholic liver disease injury through the negative regulation of the NLRP3 signaling pathway.	Triiodothyronine	0-16	NLR family, pyrin domain containing 3	Mus musculus	98-103
30140721-0	2018	Data on triiodothyronine treated peroxisome proliferator-activated receptor-alpha-null mouse hearts using magnetic resonance imaging and magnetic resonance spectroscopy.	Triiodothyronine	8-24	peroxisome proliferator activated receptor alpha	Mus musculus	33-81
30431435-0	2018	Triiodothyronine improves age-induced glucose intolerance and increases the expression of sirtuin-1 and glucose transporter-4 in skeletal muscle of aged rats.	Triiodothyronine	0-16	sirtuin 1	Rattus norvegicus	90-99
30431435-0	2018	Triiodothyronine improves age-induced glucose intolerance and increases the expression of sirtuin-1 and glucose transporter-4 in skeletal muscle of aged rats.	Triiodothyronine	0-16	solute carrier family 2 member 4	Rattus norvegicus	104-125
29908087-7	2018	In addition, we also measured mRNA expression of types 2 (DIO2) and 3 (DIO3) deiodinases that regulate triiodothyronine-mediated GnRH release and gonadal maturation in photoperiodic species.	Triiodothyronine	103-119	iodothyronine deiodinase 2	Homo sapiens	58-62
29908087-7	2018	In addition, we also measured mRNA expression of types 2 (DIO2) and 3 (DIO3) deiodinases that regulate triiodothyronine-mediated GnRH release and gonadal maturation in photoperiodic species.	Triiodothyronine	103-119	iodothyronine deiodinase 3	Homo sapiens	71-75
29845892-1	2018	BACKGROUND: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	249-265	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	107-136
29845892-1	2018	BACKGROUND: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	249-265	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	138-142
29845892-1	2018	BACKGROUND: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	267-269	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	107-136
29845892-1	2018	BACKGROUND: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	267-269	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	138-142
30233491-4	2018	Accordingly, we detected expression of alpha2A-AR, alpha2B-AR and alpha2C-AR in the skeleton, and that triiodothyronine (T3) modulates alpha2C-AR mRNA expression in the bone.	Triiodothyronine	103-119	adrenergic receptor, alpha 2c	Mus musculus	135-145
30233491-4	2018	Accordingly, we detected expression of alpha2A-AR, alpha2B-AR and alpha2C-AR in the skeleton, and that triiodothyronine (T3) modulates alpha2C-AR mRNA expression in the bone.	Triiodothyronine	121-123	adrenergic receptor, alpha 2c	Mus musculus	135-145
30013028-0	2018	Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals.	Triiodothyronine	19-35	insulin	Homo sapiens	63-70
29762250-5	2018	Thyroxine treatment for hypothyroid hippocampus and triiodothyronine treatment for hypothyroid hippocampal neurons significantly improved ephrin-A5 expression but could not restore its expression to control levels.	Triiodothyronine	52-68	ephrin A5	Rattus norvegicus	138-147
29628021-0	2018	Regulation by 3,5,3"-tri-iodothyronine and FSH of cytochrome P450 family 19 (CYP19) expression in mouse granulosa cells.	Triiodothyronine	14-38	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	77-82
29648895-2	2018	Type 1 iodothyronine deiodinase (D1) and type 2 iodothyronine deiodinase (D2) convert from thyroxine (T4) to triiodothyronine (T3).	Triiodothyronine	109-125	iodothyronine deiodinase 2	Homo sapiens	41-72
29625991-1	2018	Previously, we showed that thyroid hormone (TH) triiodothyronine (T3) enhanced beta-cell functional maturation through induction of Mafa High levels of T3 have been linked to decreased life span in mammals and low levels to lengthened life span, suggesting a relationship between TH and aging.	Triiodothyronine	66-68	MAF bZIP transcription factor A	Homo sapiens	132-136
29648895-2	2018	Type 1 iodothyronine deiodinase (D1) and type 2 iodothyronine deiodinase (D2) convert from thyroxine (T4) to triiodothyronine (T3).	Triiodothyronine	127-129	iodothyronine deiodinase 2	Homo sapiens	41-72
29427633-2	2018	Thyroid hormones (THs), such as triiodothyronine (T3) and thyroxine (T4), have a key role in mitigating metabolic responses to energy intake and expenditure, and therefore are considered important biomarkers of an animal"s energetic condition.	Triiodothyronine	32-48	metallothionein 3	Mus musculus	50-52
29603402-11	2018	The expression patterns of CRYM may reflect significance of its interactions with T3 or ketimines in these cells and organs.	Triiodothyronine	82-84	crystallin mu	Homo sapiens	27-31
29417848-0	2018	Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1alpha in murine Leydig cells.	Triiodothyronine	0-16	vascular endothelial growth factor A	Mus musculus	28-32
29417848-0	2018	Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1alpha in murine Leydig cells.	Triiodothyronine	0-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	75-85
29378220-3	2018	Additional factors that impact TH action in the brain include metabolism, activation of thyroxine (T4) to triiodothyronine (T3) by the enzyme 5"-deiodinase Type 2 (Dio2), inactivation by the enzyme 5-deiodinase Type 3 (Dio3) to reverse T3 (rT3), which occurs in glial cells, and uptake by the Mct8 transporter in neurons.	Triiodothyronine	106-122	iodothyronine deiodinase 2	Homo sapiens	142-162
29378220-3	2018	Additional factors that impact TH action in the brain include metabolism, activation of thyroxine (T4) to triiodothyronine (T3) by the enzyme 5"-deiodinase Type 2 (Dio2), inactivation by the enzyme 5-deiodinase Type 3 (Dio3) to reverse T3 (rT3), which occurs in glial cells, and uptake by the Mct8 transporter in neurons.	Triiodothyronine	106-122	iodothyronine deiodinase 2	Homo sapiens	164-168
29178319-1	2018	AIM: Based upon a microarray assay, we have identified that triiodothyronine (T3) upregulates MDM2 gene expression in the rat skeletal muscle.	Triiodothyronine	60-76	MDM2 proto-oncogene	Rattus norvegicus	94-98
29862999-4	2018	The phenotype of various RORalpha deficient mice models (staggerer mutant or mouse lacking RORalpha in specific somatosensory regions) is, in part, reminiscent of what has been described in mice lacking thyroid hormone triiodothyronine (T3).	Triiodothyronine	219-235	RAR-related orphan receptor alpha	Mus musculus	25-33
29862999-4	2018	The phenotype of various RORalpha deficient mice models (staggerer mutant or mouse lacking RORalpha in specific somatosensory regions) is, in part, reminiscent of what has been described in mice lacking thyroid hormone triiodothyronine (T3).	Triiodothyronine	237-239	RAR-related orphan receptor alpha	Mus musculus	25-33
29178319-1	2018	AIM: Based upon a microarray assay, we have identified that triiodothyronine (T3) upregulates MDM2 gene expression in the rat skeletal muscle.	Triiodothyronine	78-80	MDM2 proto-oncogene	Rattus norvegicus	94-98
29658834-8	2018	RESULTS: Following GH replacement, free thyroxine concentration declined and free triiodothyronine level increased.	Triiodothyronine	82-98	growth hormone 1	Homo sapiens	19-21
29070569-3	2018	To immortalize the cells, four hormone supplements (dexamethasone, epidermal growth factor, insulin, and triiodothyronine) were used to enhance SV40 antigen expression; however, these hormones appear to have various effects on aquaporin-2 gene expression in the cells.	Triiodothyronine	105-121	aquaporin 2	Mus musculus	227-238
29915619-7	2018	Results: By general linear analysis, a significant linear trend between free triiodothyronine (FT3) and LDL-C level (linear coefficient r = -0.082, P = 0.001) and FT3 and total cholesterol (TC) level (r = -0.105, P = 0.031) was observed in the moderate-intensity statin group.	Triiodothyronine	77-93	component of oligomeric golgi complex 2	Homo sapiens	104-109
28928085-3	2018	Cell-based reporter gene assays showed transactivation of the PDZK1-promoter by triiodothyronine mediated by thyroid hormone receptors (THR) alpha and beta.	Triiodothyronine	80-96	PDZ domain containing 1	Homo sapiens	62-67
29399988-11	2018	Uncoupling protein 1 expression in differentiated FAPs was regulated by genetic background, sex, and triiodothyronine treatment independently of adipogenic differentiation levels.	Triiodothyronine	101-117	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	0-20
29440273-0	2018	Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	41-54
29440273-2	2018	TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3).	Triiodothyronine	100-116	thyroglobulin	Homo sapiens	0-2
29440273-2	2018	TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3).	Triiodothyronine	118-120	thyroglobulin	Homo sapiens	0-2
28895643-1	2018	Thyroid hormone (3,3",5-triiodothyronine, T3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK).	Triiodothyronine	17-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	134-162
28895643-1	2018	Thyroid hormone (3,3",5-triiodothyronine, T3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK).	Triiodothyronine	17-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	164-168
28895643-1	2018	Thyroid hormone (3,3",5-triiodothyronine, T3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK).	Triiodothyronine	42-44	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	134-162
28895643-1	2018	Thyroid hormone (3,3",5-triiodothyronine, T3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK).	Triiodothyronine	42-44	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	164-168
29396447-7	2018	Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations.	Triiodothyronine	140-142	homeobox D13	Homo sapiens	38-41
29396447-7	2018	Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations.	Triiodothyronine	140-142	homeobox D13	Homo sapiens	53-56
29396447-7	2018	Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations.	Triiodothyronine	140-142	homeobox D13	Homo sapiens	53-56
29196977-7	2018	We demonstrated that SCA6-derived Purkinje cells exhibit vulnerability to triiodothyronine depletion, which is suppressed by treatment with thyrotropin-releasing hormone and Riluzole.	Triiodothyronine	74-90	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	21-25
29196977-7	2018	We demonstrated that SCA6-derived Purkinje cells exhibit vulnerability to triiodothyronine depletion, which is suppressed by treatment with thyrotropin-releasing hormone and Riluzole.	Triiodothyronine	74-90	thyrotropin releasing hormone	Homo sapiens	140-169
29171874-5	2018	RESULTS: In age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (beta = -0.045, P = .036) and inversely to free T4 (beta = -0.042, P = .050) but not to free T3 (beta = -0.027, P = .20).	Triiodothyronine	206-208	paraoxonase 1	Homo sapiens	44-49
29721936-6	2018	DIO2 converts the prohormone thyroxine (T4) to the bioactive hormone triiodothyronine (T3), and DIO3 inactivates T3 and T4.	Triiodothyronine	69-85	deiodinase, iodothyronine, type II	Mus musculus	0-4
29721936-6	2018	DIO2 converts the prohormone thyroxine (T4) to the bioactive hormone triiodothyronine (T3), and DIO3 inactivates T3 and T4.	Triiodothyronine	87-89	deiodinase, iodothyronine, type II	Mus musculus	0-4
29077876-2	2018	Triiodothyronine (T3) is known to stimulate BAT activity by increasing mitochondrial uncoupling protein 1 (Ucp1) gene transcription, leading to increased thermogenesis and decreased body weight.	Triiodothyronine	0-16	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	107-111
29077876-2	2018	Triiodothyronine (T3) is known to stimulate BAT activity by increasing mitochondrial uncoupling protein 1 (Ucp1) gene transcription, leading to increased thermogenesis and decreased body weight.	Triiodothyronine	18-20	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	107-111
29362228-7	2018	RESULTS: Positive associations between maternal serum concentrations of 4-HBP and triiodothyronine (T3), thyroxine (T4), insulin-like growth factor I (IGF-I) and its binding protein IGFBP3 were observed in mothers carrying male fetuses.	Triiodothyronine	82-98	heme binding protein 1	Homo sapiens	74-77
29362228-7	2018	RESULTS: Positive associations between maternal serum concentrations of 4-HBP and triiodothyronine (T3), thyroxine (T4), insulin-like growth factor I (IGF-I) and its binding protein IGFBP3 were observed in mothers carrying male fetuses.	Triiodothyronine	82-98	insulin like growth factor binding protein 3	Homo sapiens	182-188
29440950-3	2018	The aim of this study was to evaluate the relationship between anti TNF-alpha therapy and thyroid parameters: serum level of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and antithyroidperoxidase antibody (AbTPO) in psoriasis treated population.	Triiodothyronine	125-141	tumor necrosis factor	Homo sapiens	68-77
29175438-7	2018	Both administrations of PCB 126 elevated serum thyrotropin (TSH) concentration, and decreased free thyroxine (FT4) and free triiodothyronine (FT3) concentrations, resulting in a maternofetal hypothyroidism.	Triiodothyronine	124-140	pyruvate carboxylase	Rattus norvegicus	24-27
32259096-8	2018	Quantitative real-time PCR studies further confirmed that NS-1 cells expressed substantial levels of TRalpha and significantly less TRbeta, either of which could be responsible for the T3-dependent effects on neurite outgrowth.	Triiodothyronine	185-187	T cell receptor alpha locus	Homo sapiens	101-108
32259096-8	2018	Quantitative real-time PCR studies further confirmed that NS-1 cells expressed substantial levels of TRalpha and significantly less TRbeta, either of which could be responsible for the T3-dependent effects on neurite outgrowth.	Triiodothyronine	185-187	T cell receptor alpha locus	Homo sapiens	132-138
29272308-1	2017	Type 1 iodothyronine deiodinase (DIO1) contributes to deiodination of 3,5,3",5"-tetraiodo-L-thyronine (thyroxine, T4) yielding of 3,5,3"-triiodothyronine (T3), a powerful regulator of cell differentiation, proliferation, and metabolism.	Triiodothyronine	130-153	iodothyronine deiodinase 1	Homo sapiens	33-37
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Triiodothyronine	142-158	Kruppel-like factor 9 L homeolog	Xenopus laevis	0-21
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Triiodothyronine	142-158	Kruppel-like factor 9 L homeolog	Xenopus laevis	23-27
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Triiodothyronine	160-162	Kruppel-like factor 9 L homeolog	Xenopus laevis	0-21
29294139-5	2018	Kruppel-Like Factor 9 (klf9), the first gene induced in a cascade of TH responses tied to metamorphosis, was upregulated over 5-fold by 50 nM triiodothyronine (T3) and 2-fold by dioxin.	Triiodothyronine	160-162	Kruppel-like factor 9 L homeolog	Xenopus laevis	23-27
29294139-6	2018	Co-exposure to T3 and TCDD boosted both responses, further inducing cyp1A6 by 75% and klf9 about 60%.	Triiodothyronine	15-17	Kruppel-like factor 9 L homeolog	Xenopus laevis	86-90
31089669-3	2018	The aim of the present study was to measure soluble angiopoietin-2 serum levels in a group of thyroid-disease patients with different levels of free triiodothyronine and thyroxine.	Triiodothyronine	149-165	angiopoietin 2	Homo sapiens	52-66
31089669-7	2018	A significant positive correlation was observed between Log angiopoietin-2 levels and serum concentration of Log free triiodothyronine (r = 0.4, P < 0.001) and Log free thyroxine (r = 0.4, P < 0.001) respectively.	Triiodothyronine	118-134	angiopoietin 2	Homo sapiens	60-74
31089669-8	2018	In conclusion, increased levels of angiopoietin-2 are present in hyperthyroid patients, and seems to correlate with free triiodothyronine and free thyroxine levels but not with anti-thyroid antibodies.	Triiodothyronine	121-137	angiopoietin 2	Homo sapiens	35-49
29272308-1	2017	Type 1 iodothyronine deiodinase (DIO1) contributes to deiodination of 3,5,3",5"-tetraiodo-L-thyronine (thyroxine, T4) yielding of 3,5,3"-triiodothyronine (T3), a powerful regulator of cell differentiation, proliferation, and metabolism.	Triiodothyronine	155-157	iodothyronine deiodinase 1	Homo sapiens	33-37
29285057-2	2017	TGR5 is highly expressed in the mitochondria of brown adipose tissue (BAT) and downregulates adenosine triphosphate synthesis via the bile acid-TGR5-cyclic adenosine monophosphate-2-iodothyronine deiodinase (D2)-triiodothyronine-uncoupling protein pathway, thus regulating energy homeostasis and reducing body weight.	Triiodothyronine	212-228	G protein-coupled bile acid receptor 1	Mus musculus	0-4
28487105-0	2017	Is free triiodothyronine important in the development of insulin resistance in healthy people?	Triiodothyronine	8-24	insulin	Homo sapiens	57-64
28487105-11	2017	In the univariate regression, we found association between free triiodothyronine tertiles and insulin resistance.	Triiodothyronine	64-80	insulin	Homo sapiens	94-101
28487105-12	2017	In the multivariate regression adjusted for age, sex, body mass index and thyroid stimulating hormone, the association between free triiodothyronine tertiles and insulin resistance remained; intermediate tertile (PR=1.54; CI95%: 1.10-2.15) and high tertile (PR=1.70; CI95%: 1.21-2.39).	Triiodothyronine	132-148	insulin	Homo sapiens	162-169
28487105-14	2017	CONCLUSIONS: High levels of free triiodothyronine are associated with insulin resistance.	Triiodothyronine	33-49	insulin	Homo sapiens	70-77
29029094-5	2017	These Sbp2-deficient mice have high serum thyroxine (T4), thyrotropin, and reverse triiodothyronine (T3), similar to the human phenotype of SBP2 deficiency, whereas serum T3 is normal.	Triiodothyronine	83-99	SECIS binding protein 2	Mus musculus	6-10
29029094-5	2017	These Sbp2-deficient mice have high serum thyroxine (T4), thyrotropin, and reverse triiodothyronine (T3), similar to the human phenotype of SBP2 deficiency, whereas serum T3 is normal.	Triiodothyronine	101-103	SECIS binding protein 2	Mus musculus	6-10
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	144-160	fibronectin 1	Homo sapiens	61-72
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	144-160	fibronectin 1	Homo sapiens	74-76
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	144-160	fibronectin 1	Homo sapiens	176-178
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	144-160	fibronectin 1	Homo sapiens	176-178
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	162-164	fibronectin 1	Homo sapiens	61-72
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	162-164	fibronectin 1	Homo sapiens	74-76
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	162-164	fibronectin 1	Homo sapiens	176-178
28974422-2	2017	Hyperthyroidism is associated with elevated plasma levels of fibronectin (FN): in this study we elucidate the molecular mechanism through which triiodothyronine (T3) regulates FN and demonstrate that T3 induces FN expression via a non-canonical pathway by activating hypoxia-inducible factor-1 (HIF-1).	Triiodothyronine	162-164	fibronectin 1	Homo sapiens	176-178
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	58-74	peroxisome proliferator activated receptor alpha	Rattus norvegicus	108-156
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	58-74	peroxisome proliferator activated receptor alpha	Rattus norvegicus	158-167
28990606-5	2017	It is concluded that combined DHA-T3 supplementation achieves synergistic effects on liver PPARalpha-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders.	Triiodothyronine	34-36	peroxisome proliferator activated receptor alpha	Rattus norvegicus	91-100
28990606-5	2017	It is concluded that combined DHA-T3 supplementation achieves synergistic effects on liver PPARalpha-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders.	Triiodothyronine	34-36	fibroblast growth factor 21	Rattus norvegicus	101-106
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	58-74	fibroblast growth factor 21	Rattus norvegicus	169-196
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	58-74	fibroblast growth factor 21	Rattus norvegicus	198-203
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	76-78	peroxisome proliferator activated receptor alpha	Rattus norvegicus	108-156
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	76-78	peroxisome proliferator activated receptor alpha	Rattus norvegicus	158-167
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	76-78	fibroblast growth factor 21	Rattus norvegicus	169-196
28990606-1	2017	Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work.	Triiodothyronine	76-78	fibroblast growth factor 21	Rattus norvegicus	198-203
28551332-6	2017	Then, the stimulatory effect of both triiodothyronine (T3) and thyroxine (T4) on TRAIL was evaluated in vitro on peripheral blood mononuclear cells.	Triiodothyronine	37-53	TNF superfamily member 10	Homo sapiens	81-86
28551332-6	2017	Then, the stimulatory effect of both triiodothyronine (T3) and thyroxine (T4) on TRAIL was evaluated in vitro on peripheral blood mononuclear cells.	Triiodothyronine	55-57	TNF superfamily member 10	Homo sapiens	81-86
28938463-3	2017	Although 3,5,3"-triiodothyronine (T3) enhances FSH-induced preantral follicle growth, whether and how TH combines with FSH to regulate CYP51 expression during the preantral to early antral transition stage is unclear.	Triiodothyronine	34-36	follicle stimulating hormone beta	Mus musculus	47-50
28951438-2	2017	In pituitary, the encoding genes for growth hormone (GH) and thyroid-stimulating hormone (TSH) are examples of genes regulated by triiodothyronine (T3) in a positive and negative way, respectively.	Triiodothyronine	130-146	growth hormone 1	Homo sapiens	37-51
28938463-3	2017	Although 3,5,3"-triiodothyronine (T3) enhances FSH-induced preantral follicle growth, whether and how TH combines with FSH to regulate CYP51 expression during the preantral to early antral transition stage is unclear.	Triiodothyronine	9-32	follicle stimulating hormone beta	Mus musculus	47-50
28951438-2	2017	In pituitary, the encoding genes for growth hormone (GH) and thyroid-stimulating hormone (TSH) are examples of genes regulated by triiodothyronine (T3) in a positive and negative way, respectively.	Triiodothyronine	148-150	growth hormone 1	Homo sapiens	37-51
29065151-7	2017	In the pituitary, we observed gper expression in cells that regulate levels of thyroid hormone triiodothyronine (T3), a hormone known to increase heart rate.	Triiodothyronine	95-111	G protein-coupled estrogen receptor 1	Danio rerio	30-34
28726184-9	2017	The hazard ratio for incident MetS enhanced with increasing T3 concentration in both the crude and adjusted models.	Triiodothyronine	60-62	ETS variant transcription factor 3	Homo sapiens	30-34
29065151-7	2017	In the pituitary, we observed gper expression in cells that regulate levels of thyroid hormone triiodothyronine (T3), a hormone known to increase heart rate.	Triiodothyronine	113-115	G protein-coupled estrogen receptor 1	Danio rerio	30-34
28953452-13	2017	PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models.	Triiodothyronine	106-122	pyruvate carboxylase	Homo sapiens	0-3
28953452-13	2017	PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models.	Triiodothyronine	159-175	pyruvate carboxylase	Homo sapiens	0-3
28860448-3	2017	The THRSP gene acts as a key lipogenic activator and can be activated by thyroid hormone triiodothyronine (T3), glucose, carbohydrate and insulin.	Triiodothyronine	89-105	thyroid hormone responsive	Gallus gallus	4-9
28677796-3	2017	We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast-like MC3T3-E1 cells, and that p38 mitogen-activated protein (MAP) kinase mediates the T3-stimulated synthesis of osteocalcin.	Triiodothyronine	28-44	bone gamma-carboxyglutamate protein 2	Mus musculus	58-69
28677796-3	2017	We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast-like MC3T3-E1 cells, and that p38 mitogen-activated protein (MAP) kinase mediates the T3-stimulated synthesis of osteocalcin.	Triiodothyronine	28-44	bone gamma-carboxyglutamate protein 2	Mus musculus	207-218
28677796-3	2017	We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast-like MC3T3-E1 cells, and that p38 mitogen-activated protein (MAP) kinase mediates the T3-stimulated synthesis of osteocalcin.	Triiodothyronine	46-48	bone gamma-carboxyglutamate protein 2	Mus musculus	58-69
28677796-3	2017	We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast-like MC3T3-E1 cells, and that p38 mitogen-activated protein (MAP) kinase mediates the T3-stimulated synthesis of osteocalcin.	Triiodothyronine	46-48	bone gamma-carboxyglutamate protein 2	Mus musculus	207-218
28860448-3	2017	The THRSP gene acts as a key lipogenic activator and can be activated by thyroid hormone triiodothyronine (T3), glucose, carbohydrate and insulin.	Triiodothyronine	89-105	parathyroid hormone	Gallus gallus	73-88
28860448-3	2017	The THRSP gene acts as a key lipogenic activator and can be activated by thyroid hormone triiodothyronine (T3), glucose, carbohydrate and insulin.	Triiodothyronine	89-105	insulin	Gallus gallus	138-145
28860448-3	2017	The THRSP gene acts as a key lipogenic activator and can be activated by thyroid hormone triiodothyronine (T3), glucose, carbohydrate and insulin.	Triiodothyronine	107-109	thyroid hormone responsive	Gallus gallus	4-9
28860448-3	2017	The THRSP gene acts as a key lipogenic activator and can be activated by thyroid hormone triiodothyronine (T3), glucose, carbohydrate and insulin.	Triiodothyronine	107-109	parathyroid hormone	Gallus gallus	73-88
28785541-10	2017	CONCLUSION: The present study indicates that the combination of polymorphisms in DIO2 (rs225014) and MCT10 (rs17606253) enhances hypothyroid patients" preference for L-T4 + L-T3 replacement therapy.	Triiodothyronine	173-177	iodothyronine deiodinase 2	Homo sapiens	81-85
28550055-8	2017	The screening analysis using an OATP4C1-expressing cell system demonstrated that 22 out of 53 therapeutic drugs inhibited OATP4C1-mediated triiodothyronine transport.	Triiodothyronine	139-155	solute carrier organic anion transporter family member 4C1	Homo sapiens	32-39
28550055-8	2017	The screening analysis using an OATP4C1-expressing cell system demonstrated that 22 out of 53 therapeutic drugs inhibited OATP4C1-mediated triiodothyronine transport.	Triiodothyronine	139-155	solute carrier organic anion transporter family member 4C1	Homo sapiens	122-129
28785541-10	2017	CONCLUSION: The present study indicates that the combination of polymorphisms in DIO2 (rs225014) and MCT10 (rs17606253) enhances hypothyroid patients" preference for L-T4 + L-T3 replacement therapy.	Triiodothyronine	173-177	solute carrier family 16 member 10	Homo sapiens	101-106
28705270-5	2017	Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log (free triiodothyronine) and were inversely associated with log (thyroid peroxidase antibody) after adjustment (both P < 0.05).	Triiodothyronine	129-145	alpha 2-HS glycoprotein	Homo sapiens	61-69
28478156-2	2017	In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1.	Triiodothyronine	42-58	aryl hydrocarbon receptor	Homo sapiens	153-156
28478156-2	2017	In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1.	Triiodothyronine	42-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	195-201
28478156-2	2017	In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1.	Triiodothyronine	60-62	aryl hydrocarbon receptor	Homo sapiens	153-156
28478156-2	2017	In this study, we examined the effects of triiodothyronine (T3), a ligand and activator of thyroid hormone receptor (TR), on transcriptional activity of AhR and the expression of its target gene CYP1A1.	Triiodothyronine	60-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	195-201
28620499-0	2017	Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.	Triiodothyronine	43-59	thyroglobulin	Homo sapiens	163-176
28124751-9	2017	Also, formation of amyloid plaques was decreased in AD rats treated with T3.The results showed that T3 injection (S. C and I. H), by reduction of neural damage and increment of neuronal spontaneous activity improved the memory deficits in Abeta-induced AD rats.	Triiodothyronine	73-75	amyloid beta precursor protein	Rattus norvegicus	239-244
28124751-9	2017	Also, formation of amyloid plaques was decreased in AD rats treated with T3.The results showed that T3 injection (S. C and I. H), by reduction of neural damage and increment of neuronal spontaneous activity improved the memory deficits in Abeta-induced AD rats.	Triiodothyronine	100-102	amyloid beta precursor protein	Rattus norvegicus	239-244
28685559-4	2017	Insulin release and content (at 11.0 and 20 mmol/L glucose) were significantly (p less than 0.01) stimulated by 1-100 nmol/L T2 and 0.1 nmol/L-1.0 mumol/L T3, and inhibited with higher concentrations of both (110 mumol/L T2 and 10 mumol/L T3).	Triiodothyronine	155-157	insulin	Homo sapiens	0-7
28324105-6	2017	To study the role of triiodothyronine (T3) in Mc4r downregulation, dams received methimazole (MMI), an inhibitor of thyroid hormone production.	Triiodothyronine	39-41	melanocortin 4 receptor	Rattus norvegicus	46-50
28315333-0	2017	Triiodothyronine promotes the proliferation of epicardial progenitor cells through the MAPK/ERK pathway.	Triiodothyronine	0-16	mitogen-activated protein kinase 1	Homo sapiens	92-95
28109981-1	2017	Thyroid hormone (T3) induces liver preconditioning (PC) against ischemia-reperfusion (IR), a response energetically supported by AMP-activated protein kinase (AMPK) upregulation.	Triiodothyronine	17-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	129-157
28109981-1	2017	Thyroid hormone (T3) induces liver preconditioning (PC) against ischemia-reperfusion (IR), a response energetically supported by AMP-activated protein kinase (AMPK) upregulation.	Triiodothyronine	17-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	159-163
28685559-4	2017	Insulin release and content (at 11.0 and 20 mmol/L glucose) were significantly (p less than 0.01) stimulated by 1-100 nmol/L T2 and 0.1 nmol/L-1.0 mumol/L T3, and inhibited with higher concentrations of both (110 mumol/L T2 and 10 mumol/L T3).	Triiodothyronine	239-241	insulin	Homo sapiens	0-7
28081656-7	2017	Disease duration and age at examination inversely correlated with serum levels of free triiodothyronine (fT3) in hereditary TTR amyloidosis.	Triiodothyronine	87-103	transthyretin	Homo sapiens	124-127
28063130-6	2017	Dexamethasone interfered with forskolin increase in nuclear pCREB and its binding to Trh promoter; antibodies against histone deacetylase-3 precipitated chromatin from nuclear extracts of hypothalamic cells treated with tri-iodothyronine but not with dB-cAMP + dexamethasone, discarding chromatin compaction as responsible mechanism.	Triiodothyronine	220-237	histone deacetylase 3	Rattus norvegicus	118-139
28050799-5	2017	In this work, we demonstrate that the thyroid hormone triiodothyronine (T3) regulates actin remodeling and cell movement in breast cancer T-47D cells through the recruitment of FAK.	Triiodothyronine	54-70	protein tyrosine kinase 2	Homo sapiens	177-180
27768856-9	2017	TA4 levels are positively correlated with those of thyroxine and negatively correlated with serum levels of triiodothyronine.	Triiodothyronine	108-124	trace amine associated receptor 6	Homo sapiens	0-3
29264532-9	2017	Our data suggest that high lincRNA AS-KCNJ2 and CDT-2378E21.1 expression, possibly driven by the triiodothyronine regulatory mechanism, reduces the Kir2.1 expression observed during thyrotoxicosis.	Triiodothyronine	97-113	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	38-43
29264532-9	2017	Our data suggest that high lincRNA AS-KCNJ2 and CDT-2378E21.1 expression, possibly driven by the triiodothyronine regulatory mechanism, reduces the Kir2.1 expression observed during thyrotoxicosis.	Triiodothyronine	97-113	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	148-154
27911598-5	2017	Here we show that Dio3-/- mice of both sexes exhibit decreased adiposity, reduced brown and white adipocyte size, and enhanced fat loss in response to triiodothyronine (T3) treatment.	Triiodothyronine	151-167	deiodinase, iodothyronine type III	Mus musculus	18-22
27911598-5	2017	Here we show that Dio3-/- mice of both sexes exhibit decreased adiposity, reduced brown and white adipocyte size, and enhanced fat loss in response to triiodothyronine (T3) treatment.	Triiodothyronine	169-171	deiodinase, iodothyronine type III	Mus musculus	18-22
28050799-5	2017	In this work, we demonstrate that the thyroid hormone triiodothyronine (T3) regulates actin remodeling and cell movement in breast cancer T-47D cells through the recruitment of FAK.	Triiodothyronine	72-74	protein tyrosine kinase 2	Homo sapiens	177-180
27809680-1	2017	BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHalpha), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels.	Triiodothyronine	254-270	thyroid hormone receptor alpha	Homo sapiens	42-72
28242177-3	2017	In this study, we designed a novel series of LAT1 inhibitors, SKN101-105, based on the structure of triiodothyronine (T3), a known LAT1 blocker.	Triiodothyronine	100-116	solute carrier family 7 member 5	Homo sapiens	45-49
28242177-3	2017	In this study, we designed a novel series of LAT1 inhibitors, SKN101-105, based on the structure of triiodothyronine (T3), a known LAT1 blocker.	Triiodothyronine	100-116	solute carrier family 7 member 5	Homo sapiens	131-135
28242177-3	2017	In this study, we designed a novel series of LAT1 inhibitors, SKN101-105, based on the structure of triiodothyronine (T3), a known LAT1 blocker.	Triiodothyronine	118-120	solute carrier family 7 member 5	Homo sapiens	45-49
28242177-3	2017	In this study, we designed a novel series of LAT1 inhibitors, SKN101-105, based on the structure of triiodothyronine (T3), a known LAT1 blocker.	Triiodothyronine	118-120	solute carrier family 7 member 5	Homo sapiens	131-135
27809680-1	2017	BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHalpha), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels.	Triiodothyronine	254-270	thyroid hormone receptor alpha a	Danio rerio	74-78
27809680-7	2017	As previously described in vitro, treatment with high triiodothyronine doses can efficiently revert the observed defects only in embryos injected with missense hTRalpha variants.	Triiodothyronine	54-70	T cell receptor alpha locus	Homo sapiens	160-168
28075349-5	2017	Deiodinase 2 (D2) mediated increases in triiodothyronine levels were found to regulate the expression of myogenic marker, myogenin (MYOG).	Triiodothyronine	40-56	iodothyronine deiodinase 2	Homo sapiens	0-12
28075349-5	2017	Deiodinase 2 (D2) mediated increases in triiodothyronine levels were found to regulate the expression of myogenic marker, myogenin (MYOG).	Triiodothyronine	40-56	myogenin	Homo sapiens	122-130
28075349-5	2017	Deiodinase 2 (D2) mediated increases in triiodothyronine levels were found to regulate the expression of myogenic marker, myogenin (MYOG).	Triiodothyronine	40-56	myogenin	Homo sapiens	132-136
29022645-2	2017	Triiodothyronine (T3) regulates nuclear localization of TRIP11 by inducing its phosphorylation.	Triiodothyronine	0-16	thyroid hormone receptor interactor 11	Homo sapiens	56-62
28980233-6	2017	This local bioactive TH, triiodothyronine (T3), appears to regulate seasonal gonadotropin-releasing hormone (GnRH) secretion through morphological changes in neuro-glial interactions.	Triiodothyronine	25-41	gonadotropin releasing hormone 1	Homo sapiens	77-107
28980233-6	2017	This local bioactive TH, triiodothyronine (T3), appears to regulate seasonal gonadotropin-releasing hormone (GnRH) secretion through morphological changes in neuro-glial interactions.	Triiodothyronine	43-45	gonadotropin releasing hormone 1	Homo sapiens	77-107
28376489-0	2017	Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells.	Triiodothyronine	0-16	protein kinase cGMP-dependent 1	Homo sapiens	48-51
28376489-0	2017	Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells.	Triiodothyronine	0-16	vasodilator stimulated phosphoprotein	Homo sapiens	52-56
27320333-5	2017	Conversely, RXR is able to form "nonpermissive" heterodimers with vitamin D receptor (VDR), thyroid receptor (TR) and retinoic acid receptor (RAR), which function only in the presence of vitamin D, T3 and retinoic acid, respectively.	Triiodothyronine	198-200	retinoid X receptor alpha	Homo sapiens	12-15
27320333-5	2017	Conversely, RXR is able to form "nonpermissive" heterodimers with vitamin D receptor (VDR), thyroid receptor (TR) and retinoic acid receptor (RAR), which function only in the presence of vitamin D, T3 and retinoic acid, respectively.	Triiodothyronine	198-200	vitamin D receptor	Homo sapiens	86-89
29022645-2	2017	Triiodothyronine (T3) regulates nuclear localization of TRIP11 by inducing its phosphorylation.	Triiodothyronine	18-20	thyroid hormone receptor interactor 11	Homo sapiens	56-62
27248050-1	2016	Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-alpha (PPAR-alpha)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements.	Triiodothyronine	103-105	peroxisome proliferator activated receptor alpha	Rattus norvegicus	136-184
27918494-5	2016	Independent associates of baseline eGFR were age, hemoglobin, NLR, triiodothyronine, and pulmonary artery systolic pressure.	Triiodothyronine	67-83	epidermal growth factor receptor	Homo sapiens	35-39
27623928-5	2016	DIO2 converts thyroxine (T4) to triiodothyronine (T3), which binds to the TH receptor, whereas DIO3 degrades T3 and T4.	Triiodothyronine	32-48	deiodinase, iodothyronine, type II	Mus musculus	0-4
27623928-5	2016	DIO2 converts thyroxine (T4) to triiodothyronine (T3), which binds to the TH receptor, whereas DIO3 degrades T3 and T4.	Triiodothyronine	50-52	deiodinase, iodothyronine, type II	Mus musculus	0-4
28105345-2	2016	We previously demonstrated that triiodothyronine (T3) stimulates osteocalcin synthesis at least in part through p38 mitogen-activated protein kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	32-48	bone gamma-carboxyglutamate protein 2	Mus musculus	65-76
28105345-2	2016	We previously demonstrated that triiodothyronine (T3) stimulates osteocalcin synthesis at least in part through p38 mitogen-activated protein kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	32-48	mitogen-activated protein kinase 14	Mus musculus	112-115
28105345-2	2016	We previously demonstrated that triiodothyronine (T3) stimulates osteocalcin synthesis at least in part through p38 mitogen-activated protein kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	50-52	bone gamma-carboxyglutamate protein 2	Mus musculus	65-76
28105345-2	2016	We previously demonstrated that triiodothyronine (T3) stimulates osteocalcin synthesis at least in part through p38 mitogen-activated protein kinase in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	50-52	mitogen-activated protein kinase 14	Mus musculus	112-115
27248050-1	2016	Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-alpha (PPAR-alpha)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements.	Triiodothyronine	103-105	peroxisome proliferator activated receptor alpha	Homo sapiens	186-196
27248050-1	2016	Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-alpha (PPAR-alpha)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements.	Triiodothyronine	103-105	fibroblast growth factor 21	Rattus norvegicus	227-232
27450974-2	2016	Low tri-iodothyronine (T3) syndrome is a common complication in critically ill patients and is associated with a poor prognosis.	Triiodothyronine	23-25	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	4-7
27664134-7	2016	Intriguingly, triiodothyronine (T3) treatment rescued hypomyelination in mct8-/- embryos before the maturation of the blood-brain barrier (BBB), but did not affect hypomyelination in older larvae.	Triiodothyronine	14-30	solute carrier family 16 member 2	Danio rerio	73-77
27664134-7	2016	Intriguingly, triiodothyronine (T3) treatment rescued hypomyelination in mct8-/- embryos before the maturation of the blood-brain barrier (BBB), but did not affect hypomyelination in older larvae.	Triiodothyronine	32-34	solute carrier family 16 member 2	Danio rerio	73-77
27349864-6	2016	Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1alpha), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin.	Triiodothyronine	9-25	sirtuin 1	Homo sapiens	36-45
27349864-3	2016	Triiodothyronine also increased mitochondrial transcription factor A (TFAM) protein expression, and thyroxine stimulated complex II/IV activity.	Triiodothyronine	0-16	transcription factor A, mitochondrial	Homo sapiens	32-68
27349864-3	2016	Triiodothyronine also increased mitochondrial transcription factor A (TFAM) protein expression, and thyroxine stimulated complex II/IV activity.	Triiodothyronine	0-16	transcription factor A, mitochondrial	Homo sapiens	70-74
27349864-6	2016	Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1alpha), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin.	Triiodothyronine	9-25	fibrillin 1	Homo sapiens	47-105
27349864-6	2016	Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1alpha), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin.	Triiodothyronine	9-25	PPARG coactivator 1 alpha	Homo sapiens	107-116
27349864-6	2016	Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1alpha), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin.	Triiodothyronine	9-25	cyclin dependent kinase inhibitor 2A	Homo sapiens	177-213
27349864-6	2016	Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1alpha), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin.	Triiodothyronine	9-25	cyclin dependent kinase inhibitor 2A	Homo sapiens	215-218
27132806-0	2016	Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor alpha via direct and indirect mechanisms.	Triiodothyronine	0-16	thyroid hormone receptor alpha	Mus musculus	85-115
27444191-3	2016	Recently, in a 3-day ischemia/reperfusion rat model, the infusion of a low dose of T3 improved the post-ischemic recovery of cardiac function.Adopting this model, our study aimed to investigate the effects of T3 on the capillary index and the expression of angiogenic genes as the angiopoietins 1/2 and tyrosine kinase receptor system, in the thoracic aorta and in the left ventricle.	Triiodothyronine	83-85	angiopoietin 1	Rattus norvegicus	281-298
26866568-11	2016	Functional variants within the DIO1 gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.	Triiodothyronine	53-69	iodothyronine deiodinase 1	Homo sapiens	31-35
26866568-11	2016	Functional variants within the DIO1 gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.	Triiodothyronine	71-73	iodothyronine deiodinase 1	Homo sapiens	31-35
27528272-3	2016	Unlike the constitutively nuclear TRbeta, this GFP-GR-TRbeta chimera is cytoplasmic in the absence of hormone while translocating to the nucleus in a time- and concentration-dependent manner upon stimulation with triiodothyronine (T3) and thyroid hormone analogue, TRIAC, while the reverse triiodothyronine (3,3",5"-triiodothyronine, or rT3) was inactive.	Triiodothyronine	213-229	T cell receptor beta locus	Homo sapiens	54-60
27528272-3	2016	Unlike the constitutively nuclear TRbeta, this GFP-GR-TRbeta chimera is cytoplasmic in the absence of hormone while translocating to the nucleus in a time- and concentration-dependent manner upon stimulation with triiodothyronine (T3) and thyroid hormone analogue, TRIAC, while the reverse triiodothyronine (3,3",5"-triiodothyronine, or rT3) was inactive.	Triiodothyronine	231-233	T cell receptor beta locus	Homo sapiens	54-60
27528272-3	2016	Unlike the constitutively nuclear TRbeta, this GFP-GR-TRbeta chimera is cytoplasmic in the absence of hormone while translocating to the nucleus in a time- and concentration-dependent manner upon stimulation with triiodothyronine (T3) and thyroid hormone analogue, TRIAC, while the reverse triiodothyronine (3,3",5"-triiodothyronine, or rT3) was inactive.	Triiodothyronine	290-306	T cell receptor beta locus	Homo sapiens	54-60
27163637-2	2016	3,3",5-triiodothyroxine (T3) is a hormone secreted from the thyroid gland that has been shown to protect cells by improving the redox state and to regulate the expression of pyruvate kinase muscle isozyme (PKM, including two isoforms PKM1 and PKM2).	Triiodothyronine	25-27	pyruvate kinase M1/2	Homo sapiens	174-204
27986127-7	2016	Irisin levels were positively correlated with free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin receptor antibody (TRAb) (p = 0.03, p = 0.02, p = 0.02, respectively) and negatively correlated with thyroid-stimulating hormone (TSH) (p = 0.006) in both groups.	Triiodothyronine	51-67	fibronectin type III domain containing 5	Homo sapiens	0-6
27163637-2	2016	3,3",5-triiodothyroxine (T3) is a hormone secreted from the thyroid gland that has been shown to protect cells by improving the redox state and to regulate the expression of pyruvate kinase muscle isozyme (PKM, including two isoforms PKM1 and PKM2).	Triiodothyronine	25-27	pyruvate kinase M1/2	Homo sapiens	206-209
27163637-2	2016	3,3",5-triiodothyroxine (T3) is a hormone secreted from the thyroid gland that has been shown to protect cells by improving the redox state and to regulate the expression of pyruvate kinase muscle isozyme (PKM, including two isoforms PKM1 and PKM2).	Triiodothyronine	25-27	pyruvate kinase M1/2	Homo sapiens	243-247
27247403-2	2016	Here, we show that the thyroid hormone triiodothyronine (T3), through binding to its nuclear receptors (TRs), is able to antagonize transcriptional activation by TGF-beta/SMAD.	Triiodothyronine	39-55	transforming growth factor, beta 1	Mus musculus	162-170
27247403-2	2016	Here, we show that the thyroid hormone triiodothyronine (T3), through binding to its nuclear receptors (TRs), is able to antagonize transcriptional activation by TGF-beta/SMAD.	Triiodothyronine	57-59	transforming growth factor, beta 1	Mus musculus	162-170
27094789-0	2016	Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.	Triiodothyronine	18-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35
27347897-3	2016	The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis.	Triiodothyronine	27-43	thyrotropin releasing hormone	Homo sapiens	74-77
27347897-3	2016	The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis.	Triiodothyronine	45-47	thyrotropin releasing hormone	Homo sapiens	74-77
27462589-12	2016	TBG excess should be considered as a potential differential diagnosis for hyperthyroxinemia and especially high T3 levels with normal TSH concentration.	Triiodothyronine	112-114	serpin family A member 7	Homo sapiens	0-3
26507440-7	2016	Results indicated that GSH-Px activity and Bcl-2 mRNA level in the testes and thyroidal triiodothyronine (T3) and free triiodothyronine (FT3) levels in serum by dietary Se deficiency were significantly decreased compared to the corresponding control groups.	Triiodothyronine	106-108	BCL2, apoptosis regulator	Gallus gallus	43-48
27094789-0	2016	Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.	Triiodothyronine	0-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35
27094789-0	2016	Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.	Triiodothyronine	0-16	transforming growth factor alpha	Homo sapiens	40-44
27094789-0	2016	Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K.	Triiodothyronine	18-20	transforming growth factor alpha	Homo sapiens	40-44
27094789-2	2016	In previous studies, we demonstrated that expression of transforming growth factor alpha increases upon treatment with triiodothyronine, but this expression does not occur in cellular models that do not express the estrogen receptor, or when cells are co-treated with the anti-estrogen, tamoxifen.	Triiodothyronine	119-135	tumor necrosis factor	Homo sapiens	56-88
27094789-3	2016	The aim of this study was to determine the effect of the hormone triiodothyronine on the expression of the genes HIF1A and TGFA in the breast cancer cell line MCF7.	Triiodothyronine	65-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-118
27094789-3	2016	The aim of this study was to determine the effect of the hormone triiodothyronine on the expression of the genes HIF1A and TGFA in the breast cancer cell line MCF7.	Triiodothyronine	65-81	transforming growth factor alpha	Homo sapiens	123-127
27094789-7	2016	We found that HIF1A and TGFA expression increased in the presence of triiodothyronine at all times studied.	Triiodothyronine	69-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
27094789-7	2016	We found that HIF1A and TGFA expression increased in the presence of triiodothyronine at all times studied.	Triiodothyronine	69-85	transforming growth factor alpha	Homo sapiens	24-28
27094789-8	2016	HIF1A expression decreased in triiodothyronine-treated cells when gene transcription was also inhibited; however, TGFA expression decreased after 10 and 30min of treatment even when transcription was not inhibited.	Triiodothyronine	30-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
27094789-9	2016	We found that activation of PI3K was necessary for triiodothyronine to modulate HIF1A and TGFA expression.	Triiodothyronine	51-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
27094789-9	2016	We found that activation of PI3K was necessary for triiodothyronine to modulate HIF1A and TGFA expression.	Triiodothyronine	51-67	transforming growth factor alpha	Homo sapiens	90-94
27649316-7	2016	The epsilon4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.	Triiodothyronine	138-154	apolipoprotein E	Homo sapiens	13-17
26701289-2	2016	Mutations in the MCT8 gene lead to profound psychomotor retardation and abnormal thyroid hormone serum levels with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	143-159	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	17-21
26701289-2	2016	Mutations in the MCT8 gene lead to profound psychomotor retardation and abnormal thyroid hormone serum levels with low thyroxine (T4) and high triiodothyronine (T3).	Triiodothyronine	161-163	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	17-21
26626087-7	2016	Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake.	Triiodothyronine	122-138	thyrotropin releasing hormone	Rattus norvegicus	54-57
26892873-7	2016	Triiodothyronine positively regulated genes Tnni2 and Myog were decreased, indicating reduced TH signaling in the diaphragm.	Triiodothyronine	0-16	troponin I, skeletal, fast 2	Mus musculus	44-49
26892873-7	2016	Triiodothyronine positively regulated genes Tnni2 and Myog were decreased, indicating reduced TH signaling in the diaphragm.	Triiodothyronine	0-16	myogenin	Mus musculus	54-58
26623926-0	2016	Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-beta1 and Antifibrotic miRNA Signaling.	Triiodothyronine	21-37	transforming growth factor, beta 1	Rattus norvegicus	112-144
26754848-0	2016	Successful every-other-day liothyronine therapy for severe resistance to thyroid hormone beta with a novel THRB mutation; case report.	Triiodothyronine	27-39	thyroid hormone receptor beta	Homo sapiens	107-111
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	329-345	thyroid hormone receptor alpha	Homo sapiens	175-205
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	329-345	T cell receptor alpha locus	Homo sapiens	207-214
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	347-349	thyroid hormone receptor alpha	Homo sapiens	175-205
27094663-5	2016	Several other conditions that involve impaired sensitivity to thyroid hormone have been described in recent decades, and mutations have been identified in genes that code for thyroid hormone receptor alpha (TRalpha), a cell membrane transporter, as well as in the deiodinases that metabolise thyroxine (T4) to the bioactive form triiodothyronine (T3).	Triiodothyronine	347-349	T cell receptor alpha locus	Homo sapiens	207-214
26626087-7	2016	Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake.	Triiodothyronine	122-138	solute carrier family 16 member 2	Rattus norvegicus	58-62
26626087-7	2016	Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake.	Triiodothyronine	122-138	thyrotropin releasing hormone	Rattus norvegicus	164-167
26626087-7	2016	Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intake.	Triiodothyronine	122-138	thyrotropin releasing hormone	Rattus norvegicus	164-167
26787482-1	2016	Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the conversion of thyroxine (T4) to triiodothyronine (T3) and subsequent activation of the reproductive axis.	Triiodothyronine	198-214	thyroxine 5-deiodinase	Taeniopygia guttata	153-157
26787482-1	2016	Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the conversion of thyroxine (T4) to triiodothyronine (T3) and subsequent activation of the reproductive axis.	Triiodothyronine	216-218	thyroxine 5-deiodinase	Taeniopygia guttata	153-157
27649316-7	2016	The epsilon4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.	Triiodothyronine	165-181	apolipoprotein E	Homo sapiens	13-17
25505045-9	2015	Significant correlation was observed between CD4 count and thyroid stimulating hormone, free triiodothyronine, and free thyroxine levels (r = -0.86, r = 0.77, and r = 0.84, respectively, p < 0.0001 for all).	Triiodothyronine	93-109	CD4 molecule	Homo sapiens	45-48
26453278-8	2015	The thyroid hormone triiodothyronine prolongs duration of TRH-induced calcium spikes during 30-min exposure.	Triiodothyronine	20-36	thyrotropin releasing hormone	Mus musculus	58-61
26453278-10	2015	Amplification of TRH-induced calcium signaling by triiodothyronine further suggests the existence of a pathway for positive feedback effects of thyroid hormones probably in a non-genomic manner.	Triiodothyronine	50-66	thyrotropin releasing hormone	Mus musculus	17-20
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	19-35	T cell receptor beta locus	Homo sapiens	107-113
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	19-35	retinoid X receptor alpha	Homo sapiens	118-143
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	19-35	retinoid X receptor alpha	Homo sapiens	145-153
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	19-35	apolipoprotein E	Homo sapiens	156-160
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	37-39	T cell receptor beta locus	Homo sapiens	107-113
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	37-39	retinoid X receptor alpha	Homo sapiens	118-143
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	37-39	retinoid X receptor alpha	Homo sapiens	145-153
26519880-7	2015	In the presence of triiodothyronine (T3) and 9-cis retinoic acid, in astrocytes transfected to overexpress TRbeta and retinoid X receptor alpha (RXRalpha), apoE promoter was indirectly activated through the interaction with ME.2.	Triiodothyronine	37-39	apolipoprotein E	Homo sapiens	156-160
26498520-0	2015	Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.	Triiodothyronine	0-17	midkine	Mus musculus	128-131
26498520-0	2015	Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.	Triiodothyronine	0-17	mitogen-activated protein kinase 1	Mus musculus	132-135
26498520-0	2015	Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.	Triiodothyronine	0-17	CREB regulated transcription coactivator 1	Mus musculus	136-142
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	82-98	heat shock protein 1	Mus musculus	50-55
26441673-5	2015	These effects are associated with (i) higher expression of muscle deiodinase type 3 (DIO3), which inactivates tri-iodothyronine (T3), and lower expression of T3-activating enzyme, deiodinase type 2 (DIO2), (ii) slower net formation of T3 from its T4 precursor in muscles, and (iii) accumulation of slow fibers at the expense of fast fibers.	Triiodothyronine	110-127	iodothyronine deiodinase 3	Rattus norvegicus	59-89
26441673-5	2015	These effects are associated with (i) higher expression of muscle deiodinase type 3 (DIO3), which inactivates tri-iodothyronine (T3), and lower expression of T3-activating enzyme, deiodinase type 2 (DIO2), (ii) slower net formation of T3 from its T4 precursor in muscles, and (iii) accumulation of slow fibers at the expense of fast fibers.	Triiodothyronine	129-131	iodothyronine deiodinase 3	Rattus norvegicus	59-89
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	82-98	bone gamma-carboxyglutamate protein 2	Mus musculus	114-125
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	82-98	bone gamma-carboxyglutamate protein 2	Mus musculus	127-129
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	100-104	heat shock protein 1	Mus musculus	50-55
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	100-104	bone gamma-carboxyglutamate protein 2	Mus musculus	114-125
26151374-2	2015	Our previous study reported that unphosphorylated HSP27 has an inhibitory role in triiodothyronine (T(3))-induced osteocalcin (OC) synthesis in osteoblasts.	Triiodothyronine	100-104	bone gamma-carboxyglutamate protein 2	Mus musculus	127-129
26151374-9	2015	Under T(3) stimulation, the binding of eIF4E to eIF4G was markedly attenuated in the HSP27-overexpressing cells compared with the control cells.	Triiodothyronine	6-10	eukaryotic translation initiation factor 4E	Mus musculus	39-44
26151374-9	2015	Under T(3) stimulation, the binding of eIF4E to eIF4G was markedly attenuated in the HSP27-overexpressing cells compared with the control cells.	Triiodothyronine	6-10	heat shock protein 1	Mus musculus	85-90
26151374-11	2015	In response to T(3) stimulation, the association of eIF4E with eIF4G in the unphosphorylatable HSP27-overexpressing cells was markedly reduced compared with the phospho-mimic HSP27-overexpressing cells.	Triiodothyronine	15-19	eukaryotic translation initiation factor 4E	Mus musculus	52-57
26151374-11	2015	In response to T(3) stimulation, the association of eIF4E with eIF4G in the unphosphorylatable HSP27-overexpressing cells was markedly reduced compared with the phospho-mimic HSP27-overexpressing cells.	Triiodothyronine	15-19	heat shock protein 1	Mus musculus	95-100
26151374-11	2015	In response to T(3) stimulation, the association of eIF4E with eIF4G in the unphosphorylatable HSP27-overexpressing cells was markedly reduced compared with the phospho-mimic HSP27-overexpressing cells.	Triiodothyronine	15-19	heat shock protein 1	Mus musculus	175-180
25869399-3	2015	This study evaluated several steps of CGA synthesis and secretion in thyrotrophs and gonadotrophs of control and hypothyroid rats, acutely or chronically-treated with T3.	Triiodothyronine	167-169	chromogranin A	Rattus norvegicus	38-41
26004626-3	2015	Cells within the brain locally convert thyroxine (T4) to the biologically active triiodothyronine (T3) through the action of the selenodeiodinase type 2 iodothyronine deiodinase (DIO2).	Triiodothyronine	81-97	iodothyronine deiodinase 2	Homo sapiens	146-177
26004626-3	2015	Cells within the brain locally convert thyroxine (T4) to the biologically active triiodothyronine (T3) through the action of the selenodeiodinase type 2 iodothyronine deiodinase (DIO2).	Triiodothyronine	81-97	iodothyronine deiodinase 2	Homo sapiens	179-183
26004626-3	2015	Cells within the brain locally convert thyroxine (T4) to the biologically active triiodothyronine (T3) through the action of the selenodeiodinase type 2 iodothyronine deiodinase (DIO2).	Triiodothyronine	99-101	iodothyronine deiodinase 2	Homo sapiens	146-177
26004626-3	2015	Cells within the brain locally convert thyroxine (T4) to the biologically active triiodothyronine (T3) through the action of the selenodeiodinase type 2 iodothyronine deiodinase (DIO2).	Triiodothyronine	99-101	iodothyronine deiodinase 2	Homo sapiens	179-183
25672979-0	2015	Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor beta.	Triiodothyronine	66-82	thyroid hormone receptor beta	Mus musculus	98-127
25739512-0	2015	The long-term effects of FSH and triiodothyronine administration during the pubertal period on Connexin 43 expression and spermatogenesis efficiency in adult rats.	Triiodothyronine	33-49	gap junction protein, alpha 1	Rattus norvegicus	95-106
25549049-8	2015	Increased in alpha-MSH led to augmented TRH levels and circulating T3 levels (triiodothyronine, thyroid hormone).	Triiodothyronine	67-69	proopiomelanocortin	Rattus norvegicus	13-22
25679268-0	2015	A binding mode hypothesis of tiagabine confirms liothyronine effect on gamma-aminobutyric acid transporter 1 (GAT1).	Triiodothyronine	48-60	solute carrier family 6 member 1	Homo sapiens	71-108
25679268-0	2015	A binding mode hypothesis of tiagabine confirms liothyronine effect on gamma-aminobutyric acid transporter 1 (GAT1).	Triiodothyronine	48-60	solute carrier family 6 member 1	Homo sapiens	110-114
25679268-4	2015	Translating essential binding features into a pharmacophore model followed by in silico screening of the DrugBank identified liothyronine as a drug potentially exerting a similar effect on GAT1.	Triiodothyronine	125-137	solute carrier family 6 member 1	Homo sapiens	189-193
25549049-8	2015	Increased in alpha-MSH led to augmented TRH levels and circulating T3 levels (triiodothyronine, thyroid hormone).	Triiodothyronine	78-94	proopiomelanocortin	Rattus norvegicus	13-22
25549200-2	2015	Recent studies identified the DIO2 gene encoding type 2 deiodinase (D2) as a susceptibility locus for OA, and further data suggest deiodinase-regulated local availability of triiodothyronine (T3) in the joint plays an important role in cartilage maintenance and repair.	Triiodothyronine	174-190	deiodinase, iodothyronine, type II	Mus musculus	30-34
28834641-6	2015	A higher decrease of high-sensitivity C-reactive protein level was seen in the liothyronine group than in the placebo group (P = 0.009).	Triiodothyronine	79-91	C-reactive protein	Homo sapiens	38-56
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	27-43	fibroblast growth factor 21	Mus musculus	101-106
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	27-43	apoptosis antagonizing transcription factor	Mus musculus	182-188
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	45-47	fibroblast growth factor 21	Mus musculus	101-106
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	45-47	apoptosis antagonizing transcription factor	Mus musculus	182-188
25549200-2	2015	Recent studies identified the DIO2 gene encoding type 2 deiodinase (D2) as a susceptibility locus for OA, and further data suggest deiodinase-regulated local availability of triiodothyronine (T3) in the joint plays an important role in cartilage maintenance and repair.	Triiodothyronine	192-194	deiodinase, iodothyronine, type II	Mus musculus	30-34
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	154-170	thyroid hormone receptor beta	Danio rerio	49-78
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	154-170	thyroid hormone receptor beta	Danio rerio	80-88
25544063-6	2015	BPA displayed T3 (0.1 nM) induced zfTRbeta antagonistic activity with a median inhibitory concentration of 19.3 muM.	Triiodothyronine	14-16	thyroid hormone receptor beta	Danio rerio	34-42
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	154-170	thyroid hormone receptor beta	Danio rerio	274-282
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	172-174	thyroid hormone receptor beta	Danio rerio	49-78
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	172-174	thyroid hormone receptor beta	Danio rerio	80-88
25544063-5	2015	Using a reporter gene system to detect zebrafish thyroid hormone receptor beta (zfTRbeta) transcriptional activity, the median effective concentration of triiodothyronine (T3) was determined to be 9.2x10(-11) M. BDE-47, BDE-99, TBBPA and BPA alone, however, did not exhibit zfTRbeta agonistic activity.	Triiodothyronine	172-174	thyroid hormone receptor beta	Danio rerio	274-282
25330987-3	2015	Here, we show that triiodothyronine (T3) also works through TR to induce KLF9 in HepG2 liver cells, mouse liver, and mouse and human primary hepatocytes and sought to understand TR/KLF9 network function in the hepatocyte lineage and stem cells.	Triiodothyronine	19-35	Kruppel like factor 9	Homo sapiens	73-77
25255697-5	2015	Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group.	Triiodothyronine	5-21	insulin	Homo sapiens	53-60
25255697-8	2015	CONCLUSIONS: Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.	Triiodothyronine	18-34	insulin	Homo sapiens	88-95
25255697-8	2015	CONCLUSIONS: Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.	Triiodothyronine	18-34	insulin	Homo sapiens	181-188
25330987-3	2015	Here, we show that triiodothyronine (T3) also works through TR to induce KLF9 in HepG2 liver cells, mouse liver, and mouse and human primary hepatocytes and sought to understand TR/KLF9 network function in the hepatocyte lineage and stem cells.	Triiodothyronine	37-39	Kruppel like factor 9	Homo sapiens	73-77
25330987-3	2015	Here, we show that triiodothyronine (T3) also works through TR to induce KLF9 in HepG2 liver cells, mouse liver, and mouse and human primary hepatocytes and sought to understand TR/KLF9 network function in the hepatocyte lineage and stem cells.	Triiodothyronine	37-39	Kruppel like factor 9	Homo sapiens	181-185
25330987-3	2015	Here, we show that triiodothyronine (T3) also works through TR to induce KLF9 in HepG2 liver cells, mouse liver, and mouse and human primary hepatocytes and sought to understand TR/KLF9 network function in the hepatocyte lineage and stem cells.	Triiodothyronine	19-35	Kruppel like factor 9	Homo sapiens	181-185
27021048-5	2015	Recent studies have shown that activity of the hypothalamic mTORC1 pathway varies according to cell and stimulus types, and that this signaling cascade regulates food intake and body weight in response to nutrients, such as leucine, and hormones like leptin, ghrelin and triiodothyronine.	Triiodothyronine	271-287	CREB regulated transcription coactivator 1	Mus musculus	60-66
25896225-1	2015	The monocarboxylate transporter 8 (MCT8) gene, located on chromosome Xq13.2, encodes a thyroid hormone transporter that is involved in triiodothyronine (T3) uptake into central neurons.	Triiodothyronine	135-151	solute carrier family 16 member 2	Homo sapiens	35-39
25775381-10	2015	All subjects were grouped together for correlation analyses and HIF-1alpha was shown to correlate with total triiodothyronine (TT(3)), total thyroxine (TT(4)), and EPO levels.	Triiodothyronine	109-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
25866761-3	2015	A cell surface receptor for thyroid hormone on integrin alphavbeta3 also binds tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T4) that blocks nongenomic actions of T4 and of 3,5,3"-triiodo-L-thyronine (T3) at alphavbeta3.	Triiodothyronine	192-218	integrin subunit alpha V	Homo sapiens	47-67
25866761-3	2015	A cell surface receptor for thyroid hormone on integrin alphavbeta3 also binds tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T4) that blocks nongenomic actions of T4 and of 3,5,3"-triiodo-L-thyronine (T3) at alphavbeta3.	Triiodothyronine	220-222	integrin subunit alpha V	Homo sapiens	47-67
25993072-0	2015	Triiodothyronine modulates the expression of leptin and adiponectin in 3T3-L1 adipocytes.	Triiodothyronine	0-16	leptin	Homo sapiens	45-51
25993072-0	2015	Triiodothyronine modulates the expression of leptin and adiponectin in 3T3-L1 adipocytes.	Triiodothyronine	0-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	56-67
25993072-1	2015	OBJECTIVE: To study the effect of different doses of triiodothyronine on gene expression of the adipokines leptin and adiponectin, at different times, and to evaluate the difference in expression between the two adipokines in each group.	Triiodothyronine	53-69	leptin	Homo sapiens	107-113
25993072-1	2015	OBJECTIVE: To study the effect of different doses of triiodothyronine on gene expression of the adipokines leptin and adiponectin, at different times, and to evaluate the difference in expression between the two adipokines in each group.	Triiodothyronine	53-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	118-129
25993072-9	2015	CONCLUSION: These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin.	Triiodothyronine	55-71	leptin	Homo sapiens	79-85
25993072-9	2015	CONCLUSION: These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin.	Triiodothyronine	55-71	adiponectin, C1Q and collagen domain containing	Homo sapiens	90-101
25993072-9	2015	CONCLUSION: These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin.	Triiodothyronine	55-71	leptin	Homo sapiens	161-167
25993072-9	2015	CONCLUSION: These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin.	Triiodothyronine	55-71	adiponectin, C1Q and collagen domain containing	Homo sapiens	182-193
25993072-10	2015	Triiodothyronine stimulated or inhibited the expression of adipokines in adipocytes at different times and doses which may be useful to assist in the treatment of obesity, assuming that leptin is increased and adiponectin is decreased, in obesity cases.	Triiodothyronine	0-16	leptin	Homo sapiens	186-192
25993072-10	2015	Triiodothyronine stimulated or inhibited the expression of adipokines in adipocytes at different times and doses which may be useful to assist in the treatment of obesity, assuming that leptin is increased and adiponectin is decreased, in obesity cases.	Triiodothyronine	0-16	adiponectin, C1Q and collagen domain containing	Homo sapiens	210-221
25896225-1	2015	The monocarboxylate transporter 8 (MCT8) gene, located on chromosome Xq13.2, encodes a thyroid hormone transporter that is involved in triiodothyronine (T3) uptake into central neurons.	Triiodothyronine	135-151	solute carrier family 16 member 2	Homo sapiens	4-33
25896225-1	2015	The monocarboxylate transporter 8 (MCT8) gene, located on chromosome Xq13.2, encodes a thyroid hormone transporter that is involved in triiodothyronine (T3) uptake into central neurons.	Triiodothyronine	153-155	solute carrier family 16 member 2	Homo sapiens	4-33
25896225-1	2015	The monocarboxylate transporter 8 (MCT8) gene, located on chromosome Xq13.2, encodes a thyroid hormone transporter that is involved in triiodothyronine (T3) uptake into central neurons.	Triiodothyronine	153-155	solute carrier family 16 member 2	Homo sapiens	35-39
25967124-2	2015	We demonstrated significant benefits of acute postoperative tri-iodothyronine (T3) treatment for recovery and myocardial function.	Triiodothyronine	79-81	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	60-63
25016105-2	2014	TRbeta is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3",5-tri-iodothyronine (T3), an active form of thyroid hormone.	Triiodothyronine	85-109	thyroid hormone receptor beta	Mus musculus	0-6
25501434-3	2014	In mammals, the thyroid hormone triiodothyronine (T3) is an important driver of this process.	Triiodothyronine	32-48	parathyroid hormone	Gallus gallus	16-31
25501434-3	2014	In mammals, the thyroid hormone triiodothyronine (T3) is an important driver of this process.	Triiodothyronine	50-52	parathyroid hormone	Gallus gallus	16-31
25137026-0	2014	Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis.	Triiodothyronine	0-16	microRNA 30a	Rattus norvegicus	108-114
25137026-0	2014	Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis.	Triiodothyronine	0-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	115-118
25285637-4	2014	Although delta-T3 induced G1 arrest by up-regulating p21 in PANC-1 cells, more cells accumulated in G1 phase with the combination of delta-T3 and FA.	Triiodothyronine	15-17	H3 histone pseudogene 16	Homo sapiens	53-56
25791982-4	2015	First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr.	Triiodothyronine	24-40	progesterone receptor	Mus musculus	76-79
25791982-4	2015	First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr.	Triiodothyronine	24-40	oxytocin receptor	Mus musculus	84-88
25791982-4	2015	First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr.	Triiodothyronine	42-44	progesterone receptor	Mus musculus	76-79
25791982-4	2015	First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr.	Triiodothyronine	42-44	oxytocin receptor	Mus musculus	84-88
25465606-1	2014	OBJECTIVE: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRalpha) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.	Triiodothyronine	98-114	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	161-168
25465606-1	2014	OBJECTIVE: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRalpha) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.	Triiodothyronine	116-118	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	161-168
25465606-1	2014	OBJECTIVE: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRalpha) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.	Triiodothyronine	116-118	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	213-243
25109278-4	2014	Studies carried out in the past few years have shown that mTORC1 activity in the hypothalamus varies by cell and stimulus type, and that this complex is critically implicated in the regulation of food intake and body weight and in the central actions of both nutrients and hormones, such as leptin, ghrelin and triiodothyronine.	Triiodothyronine	311-327	CREB regulated transcription coactivator 1	Mus musculus	58-64
25016105-2	2014	TRbeta is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3",5-tri-iodothyronine (T3), an active form of thyroid hormone.	Triiodothyronine	111-113	thyroid hormone receptor beta	Mus musculus	0-6
25229406-7	2014	Interestingly, this repression did not occur in hypothyroid mice but was restored in the case of Trh by thyroid hormone (TH) treatment, highlighting the role of the triiodothyronine (T3) and TRs in this dialogue.	Triiodothyronine	165-181	thyrotropin releasing hormone	Mus musculus	97-100
25229406-7	2014	Interestingly, this repression did not occur in hypothyroid mice but was restored in the case of Trh by thyroid hormone (TH) treatment, highlighting the role of the triiodothyronine (T3) and TRs in this dialogue.	Triiodothyronine	183-185	thyrotropin releasing hormone	Mus musculus	97-100
25098716-6	2014	Triiodothyronine treatment, from days P0-P5, increased the skeletal muscle myoglobin mRNA 1.5- to 4.5-fold; a 2.5-fold increase was observed in ventricle muscle, but only when triiodothyronine treatment was extended to day P15.	Triiodothyronine	0-16	myoglobin	Rattus norvegicus	75-84
25226272-9	2014	Serum IL-37 were closely correlated with TNF-alpha, IL-6, IL-17, thyrotropin (TSH), free thyroxine (FT4),free triiodothyronine (FT3) and thyrotropin receptor antibody (TRAB).	Triiodothyronine	110-126	interleukin 37	Homo sapiens	6-11
25098716-10	2014	These results indicated that changes in triiodothyronine supply in the neonatal period alter the myoglobin expression program in ventricle and skeletal muscle, leading to specific physiological repercussions and alterations in other parameters in adulthood.	Triiodothyronine	40-56	myoglobin	Rattus norvegicus	97-106
24479416-0	2014	Authentic bosutinib inhibits triiodothyronine transport by monocarboxylate transporter 8.	Triiodothyronine	29-45	solute carrier family 16 member 2	Homo sapiens	59-88
24276222-4	2014	Dietary SPC significantly elevated the plasma free triiodothyronine (T3) in both genders and total T3 in females compared to the casein diet (P < 0.05).	Triiodothyronine	51-67	surfactant protein C	Rattus norvegicus	8-11
24276222-4	2014	Dietary SPC significantly elevated the plasma free triiodothyronine (T3) in both genders and total T3 in females compared to the casein diet (P < 0.05).	Triiodothyronine	69-71	surfactant protein C	Rattus norvegicus	8-11
24122933-0	2014	Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent beta-catenin activation in rodents.	Triiodothyronine	0-17	catenin (cadherin associated protein), beta 1	Mus musculus	81-93
24771016-0	2014	Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression.	Triiodothyronine	0-16	uncoupling protein 1	Homo sapiens	145-165
24773342-8	2014	Increased in alpha-MSH led to augmented TRH levels and circulating T3 levels (thyroid hormone).	Triiodothyronine	67-69	proopiomelanocortin	Rattus norvegicus	13-22
24936390-8	2014	RESULTS: Triiodothyronine was positively correlated with insulin but negatively correlated with glucose, high-density lipoprotein cholesterol (HDL-C), and CVR.	Triiodothyronine	9-25	insulin	Homo sapiens	57-64
24550004-6	2014	Remarkably, NCoR(DeltaID/DeltaID) Src-1(-/-) mice have normal TH and TSH levels and are triiodothryonine (T(3)) sensitive at the level of the pituitary.	Triiodothyronine	106-111	nuclear receptor co-repressor 1	Mus musculus	12-16
24550004-6	2014	Remarkably, NCoR(DeltaID/DeltaID) Src-1(-/-) mice have normal TH and TSH levels and are triiodothryonine (T(3)) sensitive at the level of the pituitary.	Triiodothyronine	106-111	nuclear receptor coactivator 1	Mus musculus	34-39
24440748-3	2014	It is known that the expression of DIO1, a gene contributing to triiodothyronine (T3) signalling, is regulated by miR-224.	Triiodothyronine	64-80	iodothyronine deiodinase 1	Homo sapiens	35-39
24322650-4	2014	DIO2 expression is tightly regulated and catalyses outer-ring monodeiodination of the secreted prohormone tetraiodothyronine (T4) to generate the active hormone tri-iodothyronine (T3).	Triiodothyronine	161-178	iodothyronine deiodinase 2	Homo sapiens	0-4
24322650-4	2014	DIO2 expression is tightly regulated and catalyses outer-ring monodeiodination of the secreted prohormone tetraiodothyronine (T4) to generate the active hormone tri-iodothyronine (T3).	Triiodothyronine	180-182	iodothyronine deiodinase 2	Homo sapiens	0-4
24692351-3	2014	Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5"-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism.	Triiodothyronine	56-72	iodothyronine deiodinase 2	Homo sapiens	82-102
24692351-3	2014	Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5"-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism.	Triiodothyronine	56-72	iodothyronine deiodinase 2	Homo sapiens	104-106
24692351-3	2014	Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5"-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism.	Triiodothyronine	74-76	iodothyronine deiodinase 2	Homo sapiens	82-102
24692351-3	2014	Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5"-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism.	Triiodothyronine	74-76	iodothyronine deiodinase 2	Homo sapiens	104-106
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	152-168	thyroglobulin	Homo sapiens	41-54
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	152-168	thyroglobulin	Homo sapiens	56-58
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	170-172	thyroglobulin	Homo sapiens	41-54
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	170-172	thyroglobulin	Homo sapiens	56-58
24623499-0	2014	Triiodothyronine induces proliferation of pancreatic beta-cells through the MAPK/ERK pathway.	Triiodothyronine	0-16	Eph receptor B1	Rattus norvegicus	81-84
25133201-4	2014	Patients with GLIS3-mediated CH exhibit diminished serum levels of thyroxine (T4) and triiodothyronine (T3) and elevated thyroid stimulating hormone (TSH) and thyroglobulin (TG).	Triiodothyronine	86-102	GLIS family zinc finger 3	Homo sapiens	14-19
25133201-4	2014	Patients with GLIS3-mediated CH exhibit diminished serum levels of thyroxine (T4) and triiodothyronine (T3) and elevated thyroid stimulating hormone (TSH) and thyroglobulin (TG).	Triiodothyronine	104-106	GLIS family zinc finger 3	Homo sapiens	14-19
24440748-3	2014	It is known that the expression of DIO1, a gene contributing to triiodothyronine (T3) signalling, is regulated by miR-224.	Triiodothyronine	64-80	microRNA 224	Homo sapiens	114-121
24440748-3	2014	It is known that the expression of DIO1, a gene contributing to triiodothyronine (T3) signalling, is regulated by miR-224.	Triiodothyronine	82-84	iodothyronine deiodinase 1	Homo sapiens	35-39
24440748-3	2014	It is known that the expression of DIO1, a gene contributing to triiodothyronine (T3) signalling, is regulated by miR-224.	Triiodothyronine	82-84	microRNA 224	Homo sapiens	114-121
24440748-4	2014	Thus, we analysed mutual regulation between triiodothyronine pathway and miR-224/miR-452/GABRE cluster.	Triiodothyronine	44-60	microRNA 224	Homo sapiens	73-80
24440748-4	2014	Thus, we analysed mutual regulation between triiodothyronine pathway and miR-224/miR-452/GABRE cluster.	Triiodothyronine	44-60	microRNA 452	Homo sapiens	81-88
24440748-4	2014	Thus, we analysed mutual regulation between triiodothyronine pathway and miR-224/miR-452/GABRE cluster.	Triiodothyronine	44-60	gamma-aminobutyric acid type A receptor subunit epsilon	Homo sapiens	89-94
24395638-2	2014	In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice.	Triiodothyronine	46-51	thyroid hormone receptor beta	Mus musculus	74-78
24361184-9	2014	CONCLUSIONS: Refeeding induces a rapid increase in muscle Slc2a4 expression, not associated with increased plasma glucose, insulin or amino acids, but highly correlated to increased plasma T3 concentration.	Triiodothyronine	189-191	solute carrier family 2 member 4	Rattus norvegicus	58-64
24368200-5	2014	Effects of 3,5,3"-triiodo-L-thyronine (T3) treatment on constitutive androstane receptor (CAR) and thyroid hormone receptors (TRs, including TRalpha and TRbeta) proteins were detected in Huh7 cells.	Triiodothyronine	39-41	nuclear receptor subfamily 1 group I member 3	Homo sapiens	56-88
24440706-1	2014	Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	17-19	thyroid hormone receptor beta	Mus musculus	124-153
24440706-1	2014	Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	17-19	thyroid hormone receptor beta	Mus musculus	155-161
24467707-1	2014	UNLABELLED: Mu-crystallin (CRYM), first described as a structural component of the eye lens in marsupials, has been characterized as an NADPH-dependent cytosolic T3 thyroid hormone (triiodothyronine) binding protein.	Triiodothyronine	162-180	crystallin, mu	Mus musculus	27-31
24467707-1	2014	UNLABELLED: Mu-crystallin (CRYM), first described as a structural component of the eye lens in marsupials, has been characterized as an NADPH-dependent cytosolic T3 thyroid hormone (triiodothyronine) binding protein.	Triiodothyronine	182-198	crystallin, mu	Mus musculus	27-31
24467707-3	2014	Here, we report three crystal structures: mouse CRYM (mCRYM) in its apo form, in a form complexed with NADPH, and in a form with both NADPH and triiodothyronine bound.	Triiodothyronine	144-160	crystallin, mu	Mus musculus	48-52
24701358-5	2014	Genes regulated by estrogen (TGFA, TGFB1, and PGR) and by triiodothyronine (TNFRSF9, BMP-6, and THRA) in vitro were evaluated.	Triiodothyronine	58-74	TNF receptor superfamily member 9	Homo sapiens	76-83
24701358-7	2014	TGFA was upregulated and downregulated after estrogen and triiodothyronine treatment, respectively.	Triiodothyronine	58-74	transforming growth factor alpha	Homo sapiens	0-4
24701358-8	2014	Triiodothyronine increased PGR expression; however 4-hydroxytamoxifen did not block triiodothyronine action on PGR expression.	Triiodothyronine	0-16	progesterone receptor	Homo sapiens	27-30
24701358-9	2014	4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment.	Triiodothyronine	45-61	TNF receptor superfamily member 9	Homo sapiens	92-99
24701358-9	2014	4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment.	Triiodothyronine	45-61	bone morphogenetic protein 6	Homo sapiens	101-106
24701358-9	2014	4-Hydroxytamoxifen, alone or associated with triiodothyronine, modulated gene expression of TNFRSF9, BMP-6, and THRA, similar to triiodothyronine treatment.	Triiodothyronine	45-61	thyroid hormone receptor alpha	Homo sapiens	112-116
24190897-6	2014	In parallel, a DR4 thyroid hormone responsive element, TGGTGAggccAGGACA, was identified at +1304 bp in the human HR gene that conferred tri-iodothyronine (T3)-independent transcriptional activation.	Triiodothyronine	136-153	major histocompatibility complex, class II, DR beta 4	Homo sapiens	15-18
24190897-6	2014	In parallel, a DR4 thyroid hormone responsive element, TGGTGAggccAGGACA, was identified at +1304 bp in the human HR gene that conferred tri-iodothyronine (T3)-independent transcriptional activation.	Triiodothyronine	155-157	major histocompatibility complex, class II, DR beta 4	Homo sapiens	15-18
24395638-2	2014	In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice.	Triiodothyronine	53-69	thyroid hormone receptor beta	Mus musculus	74-78
24646676-2	2014	A study using CRYM-null mice suggested that CRYM stores triiodothyronine (T3) in tissues.	Triiodothyronine	56-72	crystallin, mu	Mus musculus	14-18
24646676-2	2014	A study using CRYM-null mice suggested that CRYM stores triiodothyronine (T3) in tissues.	Triiodothyronine	56-72	crystallin, mu	Mus musculus	44-48
24646676-2	2014	A study using CRYM-null mice suggested that CRYM stores triiodothyronine (T3) in tissues.	Triiodothyronine	74-76	crystallin, mu	Mus musculus	14-18
24646676-2	2014	A study using CRYM-null mice suggested that CRYM stores triiodothyronine (T3) in tissues.	Triiodothyronine	74-76	crystallin, mu	Mus musculus	44-48
25767823-6	2014	Interestingly, exposure to the native thyroid hormone, triiodothyronine (T3) also led to similar responses: decreased THRbeta mRNA expression, decreased melanin pigmentation and increased apoptosis, suggesting that 6-OH-BDE 47 may be acting as a T3 mimic.	Triiodothyronine	73-75	thyroid hormone receptor beta	Danio rerio	118-125
25767823-6	2014	Interestingly, exposure to the native thyroid hormone, triiodothyronine (T3) also led to similar responses: decreased THRbeta mRNA expression, decreased melanin pigmentation and increased apoptosis, suggesting that 6-OH-BDE 47 may be acting as a T3 mimic.	Triiodothyronine	55-71	thyroid hormone receptor beta	Danio rerio	118-125
25231447-3	2014	The hereditary pattern of MCT8 mutations is X chromosome linked, with males presenting a homogeneous neurological psychomotor phenotype and mental retardation associated with low serum thyroxine and elevated triiodothyronine levels.	Triiodothyronine	208-224	solute carrier family 16 member 2	Homo sapiens	26-30
24167152-4	2013	Compared with the control group, administration of PCB 95 induced a reduction (P<0.01) in serum concentrations of thyroxine, triiodothyronine, and GH and an increase (P<0.01) in the serum concentration of TSH at PNDs 17 and 18.	Triiodothyronine	128-144	pyruvate carboxylase	Rattus norvegicus	51-54
24246949-8	2014	Induced expression of LL-37 was observed upon stimulation with triiodothyronine (T3, 2.5 nM-1 microM for 3-30 h) and thyroxine (T4, 2.5-10 nM for 24 h).	Triiodothyronine	63-79	cathelicidin antimicrobial peptide	Homo sapiens	22-27
24246949-8	2014	Induced expression of LL-37 was observed upon stimulation with triiodothyronine (T3, 2.5 nM-1 microM for 3-30 h) and thyroxine (T4, 2.5-10 nM for 24 h).	Triiodothyronine	81-83	cathelicidin antimicrobial peptide	Homo sapiens	22-27
24065084-5	2014	Iso-induced Ucp1 expression was significantly higher in the cells treated with a mixture of triiodothyronine (T3) and 3-isobutyl-1-methylxanthine (IBMX) for days 0-8 than in the control cells.	Triiodothyronine	92-108	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	12-16
24065084-5	2014	Iso-induced Ucp1 expression was significantly higher in the cells treated with a mixture of triiodothyronine (T3) and 3-isobutyl-1-methylxanthine (IBMX) for days 0-8 than in the control cells.	Triiodothyronine	110-112	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	12-16
25419525-9	2014	The binding between VDR and ERalpha ligand H6036 as well as TRalpha/beta ligand triiodothyronine and a homoserine analog thereof was confirmed by fluorescence polarization.	Triiodothyronine	80-96	T cell receptor alpha locus	Homo sapiens	60-67
24134953-0	2013	The reduced serum free triiodothyronine and increased dorsal hippocampal SNAP-25 and Munc18-1 had existed in middle-aged CD-1 mice with mild spatial cognitive impairment.	Triiodothyronine	23-39	CD1 antigen complex	Mus musculus	121-125
24345235-1	2014	The aim of this work was to examine (i) how the applied PCB mixture influences the level of 17beta-estradiol (E2) and free triiodothyronine (FT3) in the blood plasma of mice (C57/BL/6J) and (ii) whether supplementation with chitosan would protect against the observed changes in the examined plasma hormone concentrations.	Triiodothyronine	123-139	pyruvate carboxylase	Mus musculus	56-59
25744420-5	2014	Furthermore, treatment with a thyroid hormone, triiodothyronine, and a glucocorticoid receptor agonist, dexamethasone, significantly enhanced expression of the LPH, CDX-2 and HNF-1alpha genes in CDX-2/HNF-1alpha co-transfected IEC-6 cells.	Triiodothyronine	47-63	lactase	Rattus norvegicus	160-163
25744420-5	2014	Furthermore, treatment with a thyroid hormone, triiodothyronine, and a glucocorticoid receptor agonist, dexamethasone, significantly enhanced expression of the LPH, CDX-2 and HNF-1alpha genes in CDX-2/HNF-1alpha co-transfected IEC-6 cells.	Triiodothyronine	47-63	caudal type homeo box 2	Rattus norvegicus	165-170
25744420-5	2014	Furthermore, treatment with a thyroid hormone, triiodothyronine, and a glucocorticoid receptor agonist, dexamethasone, significantly enhanced expression of the LPH, CDX-2 and HNF-1alpha genes in CDX-2/HNF-1alpha co-transfected IEC-6 cells.	Triiodothyronine	47-63	HNF1 homeobox A	Rattus norvegicus	175-185
25744420-5	2014	Furthermore, treatment with a thyroid hormone, triiodothyronine, and a glucocorticoid receptor agonist, dexamethasone, significantly enhanced expression of the LPH, CDX-2 and HNF-1alpha genes in CDX-2/HNF-1alpha co-transfected IEC-6 cells.	Triiodothyronine	47-63	caudal type homeo box 2	Rattus norvegicus	195-200
25744420-5	2014	Furthermore, treatment with a thyroid hormone, triiodothyronine, and a glucocorticoid receptor agonist, dexamethasone, significantly enhanced expression of the LPH, CDX-2 and HNF-1alpha genes in CDX-2/HNF-1alpha co-transfected IEC-6 cells.	Triiodothyronine	47-63	HNF1 homeobox A	Rattus norvegicus	201-211
24754393-1	2014	Thyroid hormones (triiodothyronine, T3; and thyroxine, T4) play significant roles in development, metamorphosis, metabolism, homeostasis, cellular proliferation, and differentiation, for which the effects are mediated through thyroid hormone receptors (TRalpha and TRbeta).	Triiodothyronine	18-34	thyroid hormone receptor alpha	Salmo salar	253-260
24043460-7	2013	The finding that the KR activity of CRYM is strongly inhibited by the thyroid hormone 3,5,3"-triiodothyronine (T3) has far-reaching biomedical and clinical implications.	Triiodothyronine	111-113	crystallin mu	Homo sapiens	36-40
23886630-6	2013	PKA and MEK1/2 were regulators of ANXA2 expression, while PI3-K and triiodothyronine were additionally involved in S100 regulation.	Triiodothyronine	68-84	S100 calcium binding protein A1	Homo sapiens	115-119
23873539-4	2013	Although Thra is expressed at a higher level, only Thrb is regulated by triiodothyronine (T3).	Triiodothyronine	72-88	thyroid hormone receptor beta	Rattus norvegicus	51-55
23784545-1	2013	The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel.	Triiodothyronine	48-64	CF transmembrane conductance regulator	Homo sapiens	140-191
23784545-1	2013	The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel.	Triiodothyronine	48-64	CF transmembrane conductance regulator	Homo sapiens	193-197
23784545-1	2013	The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel.	Triiodothyronine	66-68	CF transmembrane conductance regulator	Homo sapiens	140-191
23784545-1	2013	The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel.	Triiodothyronine	66-68	CF transmembrane conductance regulator	Homo sapiens	193-197
24001430-3	2013	PCP exposure significantly downregulated basal and triiodothyronine (T3)-induced Dio 1 transcription, indicating the antagonistic activity of PCP in vitro.	Triiodothyronine	51-67	iodothyronine deiodinase 1	Rattus norvegicus	81-86
24001430-3	2013	PCP exposure significantly downregulated basal and triiodothyronine (T3)-induced Dio 1 transcription, indicating the antagonistic activity of PCP in vitro.	Triiodothyronine	69-71	iodothyronine deiodinase 1	Rattus norvegicus	81-86
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	131-147	thyroid hormone receptor beta	Mus musculus	177-206
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	131-147	thyroid hormone receptor beta	Mus musculus	208-214
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	131-147	thyroid stimulating hormone, beta subunit	Mus musculus	223-230
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	149-151	thyroid hormone receptor beta	Mus musculus	177-206
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	149-151	thyroid hormone receptor beta	Mus musculus	208-214
24055033-2	2013	A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor beta (TRbeta) on the TSHbeta gene promoter, where conventional histone-modifying coactivators act as corepressors.	Triiodothyronine	149-151	thyroid stimulating hormone, beta subunit	Mus musculus	223-230
24157158-6	2013	After adjusting for conventional risk factors (age, gender, smoking, diabetes mellitus, dyslipidemia, hypertension), free triiodothyronine (FT3) was significantly and negatively correlated with log-CKMB (r = -0.244, P < 0.001) and log-cTnI (r = -0.290, P < 0.001), indicating that the lower thyroid hormone level correlates with the severer cardiac injury in STEMI patients.	Triiodothyronine	122-138	troponin I3, cardiac type	Homo sapiens	238-242
24058635-0	2013	Triiodothyronine increases mRNA and protein leptin levels in short time in 3T3-L1 adipocytes by PI3K pathway activation.	Triiodothyronine	0-16	leptin	Mus musculus	44-50
24058635-1	2013	The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of leptin mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.	Triiodothyronine	87-103	leptin	Mus musculus	131-137
24058635-1	2013	The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of leptin mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture.	Triiodothyronine	105-107	leptin	Mus musculus	131-137
23873539-4	2013	Although Thra is expressed at a higher level, only Thrb is regulated by triiodothyronine (T3).	Triiodothyronine	90-92	thyroid hormone receptor beta	Rattus norvegicus	51-55
23896803-0	2013	Modulation of thyroid hormone receptors, TRalpha and TRbeta, by using different doses of triiodothyronine (T3) at different times.	Triiodothyronine	89-105	T cell receptor beta locus	Homo sapiens	53-59
23554160-1	2013	Thyroid hormone (T3)-induced calorigenesis triggers the hepatic production of reactive oxygen species (ROS) and redox-sensitive nuclear transcription factor erythroid 2-related factor 2 (Nrf2) activation.	Triiodothyronine	17-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	187-191
23517243-2	2013	In this study, we investigated the expression of hepatic low-density lipoprotein receptor-related protein 1 (LRP1), a receptor for remnant lipoproteins, in hypothyroidism and the effect of 3,3",5-triiodo-L-thyronine (T3) treatment on hepatic LRP1 expression.	Triiodothyronine	217-219	LDL receptor related protein 1	Homo sapiens	57-107
23517243-2	2013	In this study, we investigated the expression of hepatic low-density lipoprotein receptor-related protein 1 (LRP1), a receptor for remnant lipoproteins, in hypothyroidism and the effect of 3,3",5-triiodo-L-thyronine (T3) treatment on hepatic LRP1 expression.	Triiodothyronine	217-219	LDL receptor related protein 1	Homo sapiens	109-113
23818623-6	2013	VEGF blockade markedly increased thyroid endothelial cell apoptosis, and withdrawal of anti-VEGF resulted in full recovery of vascular density and architecture after 14 d. Prolonged anti-VEGF treatment resulted in a significant decrease of the circulating level of the predominant thyroid hormone free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid functions.	Triiodothyronine	344-360	vascular endothelial growth factor A	Mus musculus	0-4
23818623-6	2013	VEGF blockade markedly increased thyroid endothelial cell apoptosis, and withdrawal of anti-VEGF resulted in full recovery of vascular density and architecture after 14 d. Prolonged anti-VEGF treatment resulted in a significant decrease of the circulating level of the predominant thyroid hormone free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid functions.	Triiodothyronine	344-360	vascular endothelial growth factor A	Mus musculus	92-96
23818623-6	2013	VEGF blockade markedly increased thyroid endothelial cell apoptosis, and withdrawal of anti-VEGF resulted in full recovery of vascular density and architecture after 14 d. Prolonged anti-VEGF treatment resulted in a significant decrease of the circulating level of the predominant thyroid hormone free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid functions.	Triiodothyronine	344-360	vascular endothelial growth factor A	Mus musculus	92-96
23818623-6	2013	VEGF blockade markedly increased thyroid endothelial cell apoptosis, and withdrawal of anti-VEGF resulted in full recovery of vascular density and architecture after 14 d. Prolonged anti-VEGF treatment resulted in a significant decrease of the circulating level of the predominant thyroid hormone free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid functions.	Triiodothyronine	344-360	vascular endothelial growth factor A	Mus musculus	92-96
23112079-3	2013	In all species examined, similar transcriptional activities were found for triiodothyronine (T3 : 10(-11) M in TRalpha and 10(-10) M in TRbeta) and thyroxine (T4 : 10(-9) M in TRalpha and 10(-8) M in TRbeta).	Triiodothyronine	75-91	T cell receptor alpha locus	Homo sapiens	111-118
23112079-3	2013	In all species examined, similar transcriptional activities were found for triiodothyronine (T3 : 10(-11) M in TRalpha and 10(-10) M in TRbeta) and thyroxine (T4 : 10(-9) M in TRalpha and 10(-8) M in TRbeta).	Triiodothyronine	75-91	T cell receptor beta locus	Homo sapiens	136-142
23611528-5	2013	IGF-I levels were positively related to IGFBP-3, albumin, triiodothyronine and thyroxine, and inversely related to cortisol, sepsis severity, C-reactive protein, interleukin-6 and age.	Triiodothyronine	58-74	insulin like growth factor 1	Homo sapiens	0-5
23922917-4	2013	Here, we confirm that SIRT1 cooperates with PGC-1alpha to enhance response to triiodothyronine, T3.	Triiodothyronine	78-94	sirtuin 1	Homo sapiens	22-27
23922917-4	2013	Here, we confirm that SIRT1 cooperates with PGC-1alpha to enhance response to triiodothyronine, T3.	Triiodothyronine	78-94	PPARG coactivator 1 alpha	Homo sapiens	44-54
23922917-4	2013	Here, we confirm that SIRT1 cooperates with PGC-1alpha to enhance response to triiodothyronine, T3.	Triiodothyronine	96-98	sirtuin 1	Homo sapiens	22-27
23922917-4	2013	Here, we confirm that SIRT1 cooperates with PGC-1alpha to enhance response to triiodothyronine, T3.	Triiodothyronine	96-98	PPARG coactivator 1 alpha	Homo sapiens	44-54
23896803-0	2013	Modulation of thyroid hormone receptors, TRalpha and TRbeta, by using different doses of triiodothyronine (T3) at different times.	Triiodothyronine	107-109	T cell receptor beta locus	Homo sapiens	53-59
23896803-1	2013	OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRalpha and TRbeta, at different times.	Triiodothyronine	55-71	T cell receptor alpha locus	Homo sapiens	122-129
23896803-1	2013	OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRalpha and TRbeta, at different times.	Triiodothyronine	55-71	T cell receptor beta locus	Homo sapiens	134-140
23896803-1	2013	OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRalpha and TRbeta, at different times.	Triiodothyronine	73-75	T cell receptor alpha locus	Homo sapiens	122-129
23712835-12	2013	The mRNA expression of SREBP-1c and FAS was increased in iodine-loaded groups in response to the change of serum triiodothyronine.	Triiodothyronine	113-129	sterol regulatory element binding transcription factor 1	Mus musculus	23-31
23896803-1	2013	OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRalpha and TRbeta, at different times.	Triiodothyronine	73-75	T cell receptor beta locus	Homo sapiens	134-140
23712835-12	2013	The mRNA expression of SREBP-1c and FAS was increased in iodine-loaded groups in response to the change of serum triiodothyronine.	Triiodothyronine	113-129	fatty acid synthase	Mus musculus	36-39
23008094-3	2013	Primary cultures were treated with genipin, a proton leak inhibitor, guanosine diphosphate (GDP), an UCP inhibitor, and triiodothyronine (T3), an inducer of UCP gene expression.	Triiodothyronine	138-140	uncoupling protein 1	Homo sapiens	157-160
23831995-3	2013	To investigate the effects of heterodimerization, classical molecular dynamics (MD) simulations and random acceleration molecular dynamics (RAMD) simulations were performed to probe the dissociation of triiodothyronine (T3) from a TRalpha-RXR ligand binding domain (LBD) heterodimer and the TRalpha and TRbeta LBDs at the atomic level.	Triiodothyronine	202-218	T cell receptor alpha locus	Homo sapiens	231-238
23831995-3	2013	To investigate the effects of heterodimerization, classical molecular dynamics (MD) simulations and random acceleration molecular dynamics (RAMD) simulations were performed to probe the dissociation of triiodothyronine (T3) from a TRalpha-RXR ligand binding domain (LBD) heterodimer and the TRalpha and TRbeta LBDs at the atomic level.	Triiodothyronine	202-218	retinoid X receptor alpha	Homo sapiens	239-242
23305647-5	2013	In vitro exposure of immature islets to triiodothyronine enhanced the expression of Mafa, the secretion of glucose-responsive insulin, and the proportion of responsive cells, all of which are effects that were abolished in the presence of dominant-negative Mafa.	Triiodothyronine	40-56	MAF bZIP transcription factor A	Rattus norvegicus	84-88
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	69-76
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	86-94
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	106-135
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	thymoma viral proto-oncogene 1	Mus musculus	193-196
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	pancreatic and duodenal homeobox 1	Mus musculus	219-223
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	neurogenin 3	Mus musculus	225-229
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	235-239
23008094-3	2013	Primary cultures were treated with genipin, a proton leak inhibitor, guanosine diphosphate (GDP), an UCP inhibitor, and triiodothyronine (T3), an inducer of UCP gene expression.	Triiodothyronine	120-136	uncoupling protein 1	Homo sapiens	157-160
23305647-5	2013	In vitro exposure of immature islets to triiodothyronine enhanced the expression of Mafa, the secretion of glucose-responsive insulin, and the proportion of responsive cells, all of which are effects that were abolished in the presence of dominant-negative Mafa.	Triiodothyronine	40-56	MAF bZIP transcription factor A	Rattus norvegicus	257-261
23013882-1	2013	The 3,5,3"-L-triiodothyronine (T3) partly derives by the deiodination of the prohormone 3,5,3",5"-L-tetraiodothyronine (T4) by the type 2 iodothyronine deiodinase (D2).	Triiodothyronine	31-33	iodothyronine deiodinase 2	Homo sapiens	131-162
23123502-2	2013	In the present study, we investigated the involvement of Rho-kinase in the osteocalcin synthesis induced by triiodothyronine (T3) in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	108-124	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	57-67
23330919-6	2013	The estimated D6D activity was positively correlated with serum triiodothyronine (R(2) = 0.232; p < 0.001).	Triiodothyronine	64-80	fatty acid desaturase 2	Homo sapiens	14-17
23330919-7	2013	D5D activity exhibited a strong inverse correlation with serum triiodothyronine (R(2) = 0.410; p < 0.001).	Triiodothyronine	63-79	fatty acid desaturase 1	Homo sapiens	0-3
23123502-2	2013	In the present study, we investigated the involvement of Rho-kinase in the osteocalcin synthesis induced by triiodothyronine (T3) in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	108-124	bone gamma-carboxyglutamate protein 2	Mus musculus	75-86
23123502-2	2013	In the present study, we investigated the involvement of Rho-kinase in the osteocalcin synthesis induced by triiodothyronine (T3) in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	126-128	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	57-67
23123502-2	2013	In the present study, we investigated the involvement of Rho-kinase in the osteocalcin synthesis induced by triiodothyronine (T3) in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	126-128	bone gamma-carboxyglutamate protein 2	Mus musculus	75-86
23641786-10	2013	Serum IL-33 concentrations were significantly higher in Graves" disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4).	Triiodothyronine	182-198	interleukin 33	Homo sapiens	6-11
23455536-2	2013	Triiodothyronine was found to target endothelial nitric oxide synthase, which serves to enhance peripheral vascular relaxation by acting on vascular smooth muscle cells.	Triiodothyronine	0-16	nitric oxide synthase 3	Homo sapiens	37-70
23275198-1	2013	Thyroid peroxidase (TPO), which located on the apical membrane surface of thyrocytes, is the key enzyme involved in thyroid hormone synthesis, mainly catalyses the iodination of tyrosine residues and the coupling of iodotyrosines on thyroglobulin to form thyroxine and triiodothyronine.	Triiodothyronine	269-285	thyroid peroxidase	Gallus gallus	0-18
23282080-4	2013	The local synthesis of type 2 deiodinase (Dio2) promotes triiodothyronine (T3) production and summer biology, whereas type 3 deiodinase (Dio3) promotes T3 degradation and winter biology.	Triiodothyronine	57-73	type II iodothyronine deiodinase	Ovis aries	42-46
23282080-4	2013	The local synthesis of type 2 deiodinase (Dio2) promotes triiodothyronine (T3) production and summer biology, whereas type 3 deiodinase (Dio3) promotes T3 degradation and winter biology.	Triiodothyronine	75-77	type II iodothyronine deiodinase	Ovis aries	42-46
23275198-1	2013	Thyroid peroxidase (TPO), which located on the apical membrane surface of thyrocytes, is the key enzyme involved in thyroid hormone synthesis, mainly catalyses the iodination of tyrosine residues and the coupling of iodotyrosines on thyroglobulin to form thyroxine and triiodothyronine.	Triiodothyronine	269-285	thyroid peroxidase	Gallus gallus	20-23
23531789-8	2013	It is possible that locally-produced triiodothyronine resulting from the action of type 2 iodothyronine deiodinase on thyroxine stimulates the release of gonadotropins, perhaps by action on GnRH neurons.	Triiodothyronine	37-53	iodothyronine deiodinase 2	Homo sapiens	83-114
23531789-8	2013	It is possible that locally-produced triiodothyronine resulting from the action of type 2 iodothyronine deiodinase on thyroxine stimulates the release of gonadotropins, perhaps by action on GnRH neurons.	Triiodothyronine	37-53	gonadotropin releasing hormone 1	Homo sapiens	190-194
23384711-9	2013	At multivariate analysis, HMGB1 was found to be independently correlated with BMI, IL23, IL6, free triiodothyronine, HDL, and HOMA-IR.	Triiodothyronine	99-115	high mobility group box 1	Homo sapiens	26-31
23209300-4	2013	We reported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolpyruvate carboxykinase (pepck).	Triiodothyronine	17-21	carnitine palmitoyltransferase 1A	Rattus norvegicus	72-77
23255496-5	2013	In contrast to the in vitro data, fasted PPARalpha knockout mice revealed lower mRNA concentrations of pituitary TSHbeta (-64%) and TSH-regulated thyroid genes, and lower plasma concentrations of thyroxine (T4, -25%), triiodothyronine (T3, -25%), free T4 (-60%), and free T3 (-35%) than fasted WT mice (p < 0.05).	Triiodothyronine	218-234	peroxisome proliferator activated receptor alpha	Mus musculus	41-50
23255496-5	2013	In contrast to the in vitro data, fasted PPARalpha knockout mice revealed lower mRNA concentrations of pituitary TSHbeta (-64%) and TSH-regulated thyroid genes, and lower plasma concentrations of thyroxine (T4, -25%), triiodothyronine (T3, -25%), free T4 (-60%), and free T3 (-35%) than fasted WT mice (p < 0.05).	Triiodothyronine	236-238	peroxisome proliferator activated receptor alpha	Mus musculus	41-50
23515877-2	2013	We investigated the influence of triiodothyronine (T3) administration on Cx43 expression in relation to the progress in seminiferous tubule maturation.	Triiodothyronine	33-49	gap junction protein, alpha 1	Rattus norvegicus	73-77
23515877-2	2013	We investigated the influence of triiodothyronine (T3) administration on Cx43 expression in relation to the progress in seminiferous tubule maturation.	Triiodothyronine	51-53	gap junction protein, alpha 1	Rattus norvegicus	73-77
23307792-5	2013	In addition, we observed that T(3) administration significantly decreased plasma 1,25(OH)(2)D and renal CYP27B1 mRNA levels that were increased by low-calcium or low-phosphorus diets and induced hypocalcemia in mice fed a low-calcium diet.	Triiodothyronine	30-34	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	104-111
23307792-8	2013	Finally, we established that CYP27B1 gene transcription is positively regulated by SRE-binding proteins and that a T(3)-bound TRbeta1/RXRalpha heterodimer inhibits SRE-binding protein-1c-induced transcriptional activity through the 1alpha-nTRE.	Triiodothyronine	115-119	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	29-36
23307792-8	2013	Finally, we established that CYP27B1 gene transcription is positively regulated by SRE-binding proteins and that a T(3)-bound TRbeta1/RXRalpha heterodimer inhibits SRE-binding protein-1c-induced transcriptional activity through the 1alpha-nTRE.	Triiodothyronine	115-119	retinoid X receptor alpha	Homo sapiens	134-142
23072587-2	2013	3,5,3"-triiodothyronine (T(3)), the active form of TH, induces the activation of endothelial nitric oxide synthase via PI3K/AKT non-genomic signaling.	Triiodothyronine	0-23	nitric oxide synthase 3	Homo sapiens	81-114
23072587-2	2013	3,5,3"-triiodothyronine (T(3)), the active form of TH, induces the activation of endothelial nitric oxide synthase via PI3K/AKT non-genomic signaling.	Triiodothyronine	0-23	AKT serine/threonine kinase 1	Homo sapiens	124-127
23072587-2	2013	3,5,3"-triiodothyronine (T(3)), the active form of TH, induces the activation of endothelial nitric oxide synthase via PI3K/AKT non-genomic signaling.	Triiodothyronine	25-29	nitric oxide synthase 3	Homo sapiens	81-114
23072587-2	2013	3,5,3"-triiodothyronine (T(3)), the active form of TH, induces the activation of endothelial nitric oxide synthase via PI3K/AKT non-genomic signaling.	Triiodothyronine	25-29	AKT serine/threonine kinase 1	Homo sapiens	124-127
23072587-4	2013	The aim of this study was to investigate the effects of both native LDL (nLDL) and oxLDL on T(3)-mediated AKT phosphorylation, nitric oxide (NO), and cyclic guanosine monophosphate (cGMP) production in human endothelial cells.	Triiodothyronine	92-96	AKT serine/threonine kinase 1	Homo sapiens	106-109
23397370-0	2013	Triiodothyronine (T3) inhibits hyaluronate synthesis in a human dermal equivalent by downregulation of HAS2.	Triiodothyronine	0-16	hyaluronan synthase 2	Homo sapiens	103-107
23397370-0	2013	Triiodothyronine (T3) inhibits hyaluronate synthesis in a human dermal equivalent by downregulation of HAS2.	Triiodothyronine	18-20	hyaluronan synthase 2	Homo sapiens	103-107
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	93-116	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	43-46
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	93-116	gonadotropin releasing hormone receptor	Rattus norvegicus	135-149
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	93-116	gonadotropin releasing hormone receptor	Rattus norvegicus	71-73
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-123	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	43-46
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-123	gonadotropin releasing hormone receptor	Rattus norvegicus	135-149
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-123	gonadotropin releasing hormone receptor	Rattus norvegicus	71-73
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-122	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	43-46
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-122	gonadotropin releasing hormone receptor	Rattus norvegicus	135-149
23148211-2	2013	We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR).	Triiodothyronine	118-122	gonadotropin releasing hormone receptor	Rattus norvegicus	71-73
23148211-4	2013	Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH.	Triiodothyronine	77-81	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	58-61
23148211-4	2013	Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH.	Triiodothyronine	77-81	gonadotropin releasing hormone receptor	Rattus norvegicus	90-92
23148211-4	2013	Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH.	Triiodothyronine	77-81	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	143-146
23148211-4	2013	Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH.	Triiodothyronine	77-81	gonadotropin releasing hormone receptor	Rattus norvegicus	181-183
23209300-11	2013	The deacetylase activity of SIRT1 was required and PGC-1alpha was deacetylated following addition of T(3).	Triiodothyronine	101-105	PPARG coactivator 1 alpha	Rattus norvegicus	51-61
23209300-4	2013	We reported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolpyruvate carboxykinase (pepck).	Triiodothyronine	17-21	pyruvate dehydrogenase kinase 4	Rattus norvegicus	80-111
23209300-4	2013	We reported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolpyruvate carboxykinase (pepck).	Triiodothyronine	17-21	pyruvate dehydrogenase kinase 4	Rattus norvegicus	113-117
23209300-11	2013	The deacetylase activity of SIRT1 was required and PGC-1alpha was deacetylated following addition of T(3).	Triiodothyronine	101-105	sirtuin 1	Rattus norvegicus	28-33
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	22-48	ATP binding cassette subfamily D member 2	Rattus norvegicus	72-77
23147208-0	2013	Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3beta and the transcriptional factor PDX-1.	Triiodothyronine	0-16	glycogen synthase kinase 3 beta	Rattus norvegicus	96-105
23147208-0	2013	Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3beta and the transcriptional factor PDX-1.	Triiodothyronine	0-16	pancreatic and duodenal homeobox 1	Rattus norvegicus	137-142
23147208-0	2013	Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3beta and the transcriptional factor PDX-1.	Triiodothyronine	18-20	glycogen synthase kinase 3 beta	Rattus norvegicus	96-105
23147208-0	2013	Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3beta and the transcriptional factor PDX-1.	Triiodothyronine	18-20	pancreatic and duodenal homeobox 1	Rattus norvegicus	137-142
22974658-1	2013	Thyroid hormone receptor (TR)/peroxisome proliferator activated receptor coactivator (PGC-1alpha) interactions are required for T(3)-dependent transcriptional responses involved in adaptive thermogenesis and liver.	Triiodothyronine	128-132	PPARG coactivator 1 alpha	Homo sapiens	86-96
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	22-48	neural cell adhesion molecule 1	Rattus norvegicus	119-148
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	22-48	neural cell adhesion molecule 1	Rattus norvegicus	150-154
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	50-52	ATP binding cassette subfamily D member 2	Rattus norvegicus	72-77
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	50-52	neural cell adhesion molecule 1	Rattus norvegicus	119-148
23225827-2	2013	We determined whether 3,3",5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte lineage differentiation.	Triiodothyronine	50-52	neural cell adhesion molecule 1	Rattus norvegicus	150-154
23143598-4	2012	Igsf1-deficient male mice show diminished pituitary and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass.	Triiodothyronine	197-213	immunoglobulin superfamily, member 1	Mus musculus	0-5
22930759-4	2012	We demonstrate that posttranslational modification of TR by conjugation of small SUMO to TRalpha and TRbeta plays an important role in triiodothyronine (T3) action and TR isoform specificity.	Triiodothyronine	135-151	T cell receptor alpha locus	Homo sapiens	89-96
22576662-2	2012	In the present study, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was directly upregulated by T(3) in TR-overexpressing hepatoma cell lines.	Triiodothyronine	120-124	TNF superfamily member 10	Homo sapiens	22-91
22576662-6	2012	Moreover, T(3)-enhanced metastasis in vivo was repressed by the treatment of TRAIL-blocking antibody.	Triiodothyronine	10-14	TNF superfamily member 10	Homo sapiens	77-82
22956722-15	2012	However, decreased liver DIO1 and pituitary DIO2 enzyme activities indicate compensatory-adaptive changes in local T(3) production.	Triiodothyronine	115-119	iodothyronine deiodinase 1	Rattus norvegicus	25-29
22956722-15	2012	However, decreased liver DIO1 and pituitary DIO2 enzyme activities indicate compensatory-adaptive changes in local T(3) production.	Triiodothyronine	115-119	iodothyronine deiodinase 2	Rattus norvegicus	44-48
22967501-4	2012	Since FAT/CD36 is involved in the utilization of free fatty acids by skeletal muscle, specifically in their import into that tissue and presumably their oxidation at the mitochondrial level, we hypothesized that related changes in lipid handling and in FAT/CD36 expression and subcellular redistribution would occur due to hypothyroidism and to T(3) or T(2) administration to hypothyroid rats.	Triiodothyronine	345-349	CD36 molecule	Rattus norvegicus	6-9
22967501-4	2012	Since FAT/CD36 is involved in the utilization of free fatty acids by skeletal muscle, specifically in their import into that tissue and presumably their oxidation at the mitochondrial level, we hypothesized that related changes in lipid handling and in FAT/CD36 expression and subcellular redistribution would occur due to hypothyroidism and to T(3) or T(2) administration to hypothyroid rats.	Triiodothyronine	345-349	CD36 molecule	Rattus norvegicus	253-256
23023068-8	2012	Interestingly, triiodothyronine (T3) induced de novo expression of adult fast and alpha-cardiac MyHC in vitro making our culture system a valuable tool to study de novo expression of adult MyHC isoforms and its regulation by intrinsic and/or extrinsic factors.	Triiodothyronine	15-31	myosin heavy chain 3	Sus scrofa	96-100
23023068-8	2012	Interestingly, triiodothyronine (T3) induced de novo expression of adult fast and alpha-cardiac MyHC in vitro making our culture system a valuable tool to study de novo expression of adult MyHC isoforms and its regulation by intrinsic and/or extrinsic factors.	Triiodothyronine	15-31	myosin heavy chain 3	Sus scrofa	189-193
23023068-8	2012	Interestingly, triiodothyronine (T3) induced de novo expression of adult fast and alpha-cardiac MyHC in vitro making our culture system a valuable tool to study de novo expression of adult MyHC isoforms and its regulation by intrinsic and/or extrinsic factors.	Triiodothyronine	33-35	myosin heavy chain 3	Sus scrofa	96-100
23023068-8	2012	Interestingly, triiodothyronine (T3) induced de novo expression of adult fast and alpha-cardiac MyHC in vitro making our culture system a valuable tool to study de novo expression of adult MyHC isoforms and its regulation by intrinsic and/or extrinsic factors.	Triiodothyronine	33-35	myosin heavy chain 3	Sus scrofa	189-193
22930759-4	2012	We demonstrate that posttranslational modification of TR by conjugation of small SUMO to TRalpha and TRbeta plays an important role in triiodothyronine (T3) action and TR isoform specificity.	Triiodothyronine	135-151	T cell receptor beta locus	Homo sapiens	101-107
22930759-4	2012	We demonstrate that posttranslational modification of TR by conjugation of small SUMO to TRalpha and TRbeta plays an important role in triiodothyronine (T3) action and TR isoform specificity.	Triiodothyronine	153-155	T cell receptor alpha locus	Homo sapiens	89-96
22930759-4	2012	We demonstrate that posttranslational modification of TR by conjugation of small SUMO to TRalpha and TRbeta plays an important role in triiodothyronine (T3) action and TR isoform specificity.	Triiodothyronine	153-155	T cell receptor beta locus	Homo sapiens	101-107
22743177-9	2012	CONCLUSIONS: The preoperative and postoperative cytokine levels, in particular, interleukin-1beta, showed complex time-dependent relationships with triiodothyronine.	Triiodothyronine	148-164	interleukin 1 beta	Homo sapiens	80-97
22912404-3	2012	Here we show that reduced energy expenditure in FAAH(-/-) mice could be attributed to decreased circulating triiodothyronine and thyroxine concentrations secondary to reduced mRNA expression of both pituitary thyroid-stimulating hormone and hypothalamic thyrotropin-releasing hormone.	Triiodothyronine	108-124	fatty acid amide hydrolase	Mus musculus	48-52
22723621-5	2012	RESULTS: We found MCT8 and D3 but not D2 protein expression to be present in our earliest sample of 17 weeks of gestation, indicating triiodothyronine degradation, but not production at this time of development.	Triiodothyronine	134-150	solute carrier family 16 member 2	Homo sapiens	18-22
22548953-8	2012	One randomized controlled trial found that patients with the D2 Thr92Ala polymorphism had more baseline symptoms than those with the wild type D2 and experienced significantly greater symptomatic improvement in response to combined levothyroxine and liothyronine therapy.	Triiodothyronine	250-262	iodothyronine deiodinase 2	Homo sapiens	61-63
22548953-11	2012	A subset of hypothyroid patients has a polymorphism in the gene encoding the D2 enzyme that may prevent full resolution of symptoms with levothyroxine therapy alone; these patients may benefit from combination levothyroxine and liothyronine therapy.	Triiodothyronine	228-240	iodothyronine deiodinase 2	Homo sapiens	77-79
22548953-6	2012	A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.	Triiodothyronine	103-119	iodothyronine deiodinase 2	Homo sapiens	51-63
22548953-6	2012	A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.	Triiodothyronine	103-119	iodothyronine deiodinase 2	Homo sapiens	65-67
22931295-4	2012	RESULTS: PCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake.	Triiodothyronine	132-148	pyruvate carboxylase	Homo sapiens	9-12
22105890-4	2012	The present study investigates the role of peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) in cardiac hypertrophy induced by Triiodothyronine (T3).	Triiodothyronine	165-181	PPARG coactivator 1 alpha	Rattus norvegicus	43-117
22105890-4	2012	The present study investigates the role of peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) in cardiac hypertrophy induced by Triiodothyronine (T3).	Triiodothyronine	165-181	PPARG coactivator 1 alpha	Rattus norvegicus	119-129
22105890-4	2012	The present study investigates the role of peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) in cardiac hypertrophy induced by Triiodothyronine (T3).	Triiodothyronine	183-185	PPARG coactivator 1 alpha	Rattus norvegicus	43-117
22105890-4	2012	The present study investigates the role of peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) in cardiac hypertrophy induced by Triiodothyronine (T3).	Triiodothyronine	183-185	PPARG coactivator 1 alpha	Rattus norvegicus	119-129
22575839-0	2012	Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway.	Triiodothyronine	96-112	AKT serine/threonine kinase 1	Homo sapiens	128-131
23070090-9	2012	Triiodothyronine induced also modest activation of AMPK/ACC axis with subsequent increased expression of mitochondrial proteins: CPT I and CS.	Triiodothyronine	0-16	carnitine palmitoyltransferase 1B	Rattus norvegicus	129-134
22554475-3	2012	Treatment of hens with CORT stimulated an increase (P<0.05) in plasma CORT, glucose, uric acid (UA), insulin, cholesterol (Chol) and triiodothyronine (T(3)), but the concentrations of plasma non-esterified fatty acids (NEFA) and triacylglycerol (TG) were decreased (P<0.05).	Triiodothyronine	136-152	CORT	Gallus gallus	23-27
22554475-3	2012	Treatment of hens with CORT stimulated an increase (P<0.05) in plasma CORT, glucose, uric acid (UA), insulin, cholesterol (Chol) and triiodothyronine (T(3)), but the concentrations of plasma non-esterified fatty acids (NEFA) and triacylglycerol (TG) were decreased (P<0.05).	Triiodothyronine	154-158	CORT	Gallus gallus	23-27
23070090-9	2012	Triiodothyronine induced also modest activation of AMPK/ACC axis with subsequent increased expression of mitochondrial proteins: CPT I and CS.	Triiodothyronine	0-16	citrate synthase	Rattus norvegicus	139-141
21826653-12	2012	These findings support a model in which T(3) activates intracellular signaling pathways which may be involved in the increment of SREBP-1 level through an IRES-mediated translation mechanism.	Triiodothyronine	40-44	sterol regulatory element binding transcription factor 1	Homo sapiens	130-137
22502900-0	2012	Association of serum triiodothyronine with B-type natriuretic peptide and severe left ventricular diastolic dysfunction in heart failure with preserved ejection fraction.	Triiodothyronine	21-37	natriuretic peptide B	Homo sapiens	43-69
22570332-9	2012	We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover.	Triiodothyronine	16-20	microsomal triglyceride transfer protein	Mus musculus	159-162
22570332-9	2012	We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover.	Triiodothyronine	16-20	microsomal triglyceride transfer protein	Mus musculus	195-198
22570332-9	2012	We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover.	Triiodothyronine	102-106	microsomal triglyceride transfer protein	Mus musculus	159-162
22570332-9	2012	We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover.	Triiodothyronine	102-106	microsomal triglyceride transfer protein	Mus musculus	195-198
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	20-36	solute carrier family 2 member 4	Rattus norvegicus	97-102
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	20-36	solute carrier family 2 member 1	Rattus norvegicus	104-109
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	20-36	solute carrier family 2 member 3	Rattus norvegicus	115-120
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	38-42	solute carrier family 2 member 4	Rattus norvegicus	97-102
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	38-42	solute carrier family 2 member 1	Rattus norvegicus	104-109
22663547-3	2012	Here, we assess how triiodothyronine (T(3)) acutely affects glucose transport and the content of GLUT4, GLUT1, and GLUT3 at the surface of muscle cells, and possible interactions between T(3) and insulin action.	Triiodothyronine	38-42	solute carrier family 2 member 3	Rattus norvegicus	115-120
22663547-10	2012	Moreover, within 30 minutes, T(3) stimulation of glucose uptake was additive to that of insulin in L6-GLUT4myc cells.	Triiodothyronine	29-33	solute carrier family 2 member 4	Rattus norvegicus	102-107
22258767-6	2012	Triiodothyronine at 1 nmol l-1 increased GLUT1 and GLUT3 abundance in membranes.	Triiodothyronine	0-16	solute carrier family 2 member 1	Rattus norvegicus	41-46
22258767-6	2012	Triiodothyronine at 1 nmol l-1 increased GLUT1 and GLUT3 abundance in membranes.	Triiodothyronine	0-16	solute carrier family 2 member 3	Rattus norvegicus	51-56
22638834-10	2012	At 30 days-old, Lep offspring showed lower TSH ( - 48%), T3 ( - 20%), and mGPDm ( - 42%).	Triiodothyronine	57-59	leptin	Rattus norvegicus	16-19
21826653-7	2012	Conversely, the effect of T(3) on SREBP-1 level was enhanced by using rapamycin, mTOR-C1 inhibitor.	Triiodothyronine	26-30	sterol regulatory element binding transcription factor 1	Homo sapiens	34-41
21826653-7	2012	Conversely, the effect of T(3) on SREBP-1 level was enhanced by using rapamycin, mTOR-C1 inhibitor.	Triiodothyronine	26-30	CREB regulated transcription coactivator 1	Mus musculus	81-88
21826653-10	2012	These inhibitors increased the action of T(3) on Akt phosphorylation suggesting that conventional PKCs may work as negative regulators of the T(3) -dependent SREBP-1 increase.	Triiodothyronine	41-45	AKT serine/threonine kinase 1	Homo sapiens	49-52
21826653-10	2012	These inhibitors increased the action of T(3) on Akt phosphorylation suggesting that conventional PKCs may work as negative regulators of the T(3) -dependent SREBP-1 increase.	Triiodothyronine	41-45	sterol regulatory element binding transcription factor 1	Homo sapiens	158-165
22421446-6	2012	3,3",5-Tri-iodo-l-thyronine stimulated phosphorylation of extracellular signal-regulated kinase and AKT (also known as Protein Kinase B [PKB]) signaling pathways.	Triiodothyronine	0-27	AKT serine/threonine kinase 1	Homo sapiens	58-103
21826653-10	2012	These inhibitors increased the action of T(3) on Akt phosphorylation suggesting that conventional PKCs may work as negative regulators of the T(3) -dependent SREBP-1 increase.	Triiodothyronine	142-146	AKT serine/threonine kinase 1	Homo sapiens	49-52
21826653-10	2012	These inhibitors increased the action of T(3) on Akt phosphorylation suggesting that conventional PKCs may work as negative regulators of the T(3) -dependent SREBP-1 increase.	Triiodothyronine	142-146	sterol regulatory element binding transcription factor 1	Homo sapiens	158-165
22421446-6	2012	3,3",5-Tri-iodo-l-thyronine stimulated phosphorylation of extracellular signal-regulated kinase and AKT (also known as Protein Kinase B [PKB]) signaling pathways.	Triiodothyronine	0-27	protein tyrosine kinase 2 beta	Homo sapiens	119-135
22525353-2	2012	Recently, we demonstrated that triiodothyronine (T3) rapidly increases AT1R mRNA and protein levels in cardiomyocyte cultures.	Triiodothyronine	31-47	angiotensin II receptor type 1	Homo sapiens	71-75
22667453-2	2012	However, little is known about their role in protein expression at the post-transcriptional level, even though studies have shown enhancement of protein synthesis associated with mTOR/p70S6K activation after triiodo-L-thyronine (T3) administration.	Triiodothyronine	208-227	mechanistic target of rapamycin kinase	Rattus norvegicus	179-183
22667453-2	2012	However, little is known about their role in protein expression at the post-transcriptional level, even though studies have shown enhancement of protein synthesis associated with mTOR/p70S6K activation after triiodo-L-thyronine (T3) administration.	Triiodothyronine	208-227	ribosomal protein S6 kinase B1	Rattus norvegicus	184-190
22667453-2	2012	However, little is known about their role in protein expression at the post-transcriptional level, even though studies have shown enhancement of protein synthesis associated with mTOR/p70S6K activation after triiodo-L-thyronine (T3) administration.	Triiodothyronine	229-231	ribosomal protein S6 kinase B1	Rattus norvegicus	184-190
22525353-2	2012	Recently, we demonstrated that triiodothyronine (T3) rapidly increases AT1R mRNA and protein levels in cardiomyocyte cultures.	Triiodothyronine	49-51	angiotensin II receptor type 1	Homo sapiens	71-75
22442145-6	2012	By contrast, T(3) treatment inhibited Wnt signaling in osteoblastic cells, suggesting that T(3) inhibits the Wnt pathway by facilitating proteasomal degradation of beta-catenin and preventing its accumulation in the nucleus.	Triiodothyronine	13-17	catenin (cadherin associated protein), beta 1	Mus musculus	164-176
22442145-6	2012	By contrast, T(3) treatment inhibited Wnt signaling in osteoblastic cells, suggesting that T(3) inhibits the Wnt pathway by facilitating proteasomal degradation of beta-catenin and preventing its accumulation in the nucleus.	Triiodothyronine	91-95	catenin (cadherin associated protein), beta 1	Mus musculus	164-176
22383522-1	2012	We have discovered that 3,3",5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 A resolution.	Triiodothyronine	49-51	prolactin induced protein	Homo sapiens	75-78
22107247-0	2012	BMP-2 embedded atelocollagen scaffold for tissue-engineered cartilage cultured in the medium containing insulin and triiodothyronine--a new protocol for three-dimensional in vitro culture of human chondrocytes.	Triiodothyronine	116-132	bone morphogenetic protein 2	Homo sapiens	0-5
22277881-2	2012	Corepressors such as nuclear hormone receptor corepressor (NCoR) are recruited by unliganded TRs, whereas coactivators such as steroid receptor coactivator-2 (SRC2) are recruited when triiodothyronine (T3) is bound to TRs.	Triiodothyronine	184-200	nuclear receptor coactivator 2	Homo sapiens	127-157
22277881-2	2012	Corepressors such as nuclear hormone receptor corepressor (NCoR) are recruited by unliganded TRs, whereas coactivators such as steroid receptor coactivator-2 (SRC2) are recruited when triiodothyronine (T3) is bound to TRs.	Triiodothyronine	184-200	nuclear receptor coactivator 2	Homo sapiens	159-163
22277881-2	2012	Corepressors such as nuclear hormone receptor corepressor (NCoR) are recruited by unliganded TRs, whereas coactivators such as steroid receptor coactivator-2 (SRC2) are recruited when triiodothyronine (T3) is bound to TRs.	Triiodothyronine	202-204	nuclear receptor coactivator 2	Homo sapiens	127-157
22277881-2	2012	Corepressors such as nuclear hormone receptor corepressor (NCoR) are recruited by unliganded TRs, whereas coactivators such as steroid receptor coactivator-2 (SRC2) are recruited when triiodothyronine (T3) is bound to TRs.	Triiodothyronine	202-204	nuclear receptor coactivator 2	Homo sapiens	159-163
22383522-1	2012	We have discovered that 3,3",5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 A resolution.	Triiodothyronine	49-51	proliferating cell nuclear antigen	Homo sapiens	103-137
22383522-1	2012	We have discovered that 3,3",5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 A resolution.	Triiodothyronine	49-51	proliferating cell nuclear antigen	Homo sapiens	139-143
22383522-1	2012	We have discovered that 3,3",5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 A resolution.	Triiodothyronine	49-51	proliferating cell nuclear antigen	Homo sapiens	241-245
22185956-5	2012	RESULTS: LDLR(-/-) mice had a higher concentration of nuclear SREBP-1, higher concentrations of thyroxine and triiodothyronine in plasma, a lower expression of relevant UGT1A isoforms, reduced activities of pNP-UGT, T(3)-UGT and T(4)-UGT and a lower mRNA and protein concentration of AhR in the liver than wild-type mice (P<0.05).	Triiodothyronine	110-126	low density lipoprotein receptor	Mus musculus	9-13
22505424-0	2012	Crystallization and preliminary crystallographic analysis of the complex between triiodothyronine and the bb" fragment of rat protein disulfide isomerase.	Triiodothyronine	81-97	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	126-153
22505424-1	2012	Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation of a disulfide bond in nascent and misfolded proteins and is also known to bind to the thyroid hormone triiodothyronine (T3).	Triiodothyronine	195-211	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-27
22505424-1	2012	Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation of a disulfide bond in nascent and misfolded proteins and is also known to bind to the thyroid hormone triiodothyronine (T3).	Triiodothyronine	195-211	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	29-32
22505424-1	2012	Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation of a disulfide bond in nascent and misfolded proteins and is also known to bind to the thyroid hormone triiodothyronine (T3).	Triiodothyronine	213-215	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-27
22505424-1	2012	Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation of a disulfide bond in nascent and misfolded proteins and is also known to bind to the thyroid hormone triiodothyronine (T3).	Triiodothyronine	213-215	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	29-32
22171322-9	2012	PAI-1 overexpression enhanced tumor growth and migration in a manner similar to what was seen when T(3) induced PAI-1 expression in J7-TRalpha1 cells, both in vitro and in vivo.	Triiodothyronine	99-103	serpin family E member 1	Homo sapiens	112-117
22075271-10	2012	The ability of CD34+ cells to form mineralized nodules increased after exposure from low up to high-normal triiodothyronine concentrations (P for trend = .003).	Triiodothyronine	107-123	CD34 molecule	Homo sapiens	15-19
22075271-12	2012	Exposure of CD34+ cells to physiological triiodothyronine concentrations stimulates mineralization in vitro.	Triiodothyronine	41-57	CD34 molecule	Homo sapiens	12-16
22247018-0	2012	Novel compound heterozygous mutations in the SBP2 gene: characteristic clinical manifestations and the implications of GH and triiodothyronine in longitudinal bone growth and maturation.	Triiodothyronine	126-142	SECIS binding protein 2	Homo sapiens	45-49
22988323-0	2012	Comparison between the effect of liothyronine and piracetam on personal information, orientation and mental control in patients under treatment with ECT.	Triiodothyronine	33-45	ECT	Homo sapiens	149-152
22988323-1	2012	OBJECTIVE: The study aimed to compare the effect of liothyronine and piracetam on three subscales of the Wechsler memory test on patients under treatment with ECT.	Triiodothyronine	52-64	ECT	Homo sapiens	3-6
22171322-11	2012	To our knowledge, these results demonstrate for the first time that proteins involved in the urokinase plasminogen activator system, including PAI-1, uPAR, and BSSP4, are augmented in the extra- and intracellular space of T(3)-treated HepG2-TRalpha1 cells.	Triiodothyronine	222-226	serpin family E member 1	Homo sapiens	143-148
22171322-11	2012	To our knowledge, these results demonstrate for the first time that proteins involved in the urokinase plasminogen activator system, including PAI-1, uPAR, and BSSP4, are augmented in the extra- and intracellular space of T(3)-treated HepG2-TRalpha1 cells.	Triiodothyronine	222-226	plasminogen activator, urokinase receptor	Homo sapiens	150-154
22171322-11	2012	To our knowledge, these results demonstrate for the first time that proteins involved in the urokinase plasminogen activator system, including PAI-1, uPAR, and BSSP4, are augmented in the extra- and intracellular space of T(3)-treated HepG2-TRalpha1 cells.	Triiodothyronine	222-226	serine protease 22	Homo sapiens	160-165
22361821-1	2012	Thyroid hormone (T(3)) can trigger a massive differentiation of cultured oligodendrocytes precursor cells (OPC) by binding the nuclear T(3) receptor alpha1 (TRalpha1).	Triiodothyronine	17-21	thyroid hormone receptor alpha	Mus musculus	135-155
22361821-1	2012	Thyroid hormone (T(3)) can trigger a massive differentiation of cultured oligodendrocytes precursor cells (OPC) by binding the nuclear T(3) receptor alpha1 (TRalpha1).	Triiodothyronine	17-21	thyroid hormone receptor alpha	Mus musculus	157-165
22349409-1	2012	We have previously shown that the thyroid hormone triiodothyronine negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene (APP) in cultured murine neuroblastoma cells, by a mechanism that involves binding of the nuclear thyroid hormone receptor (TR) to DNA sequences located within the first exon of the gene.	Triiodothyronine	50-66	amyloid beta (A4) precursor protein	Mus musculus	124-154
22201216-10	2012	In GH3 cells, levels of mRNA and protein of GH stimulated by T(3) were reduced by 4"-OH-PBDE and 4"-MeO-PBDE.	Triiodothyronine	61-65	gonadotropin releasing hormone receptor	Rattus norvegicus	3-5
22360852-0	2012	Triiodothyronine stimulates cystatin C production in bone cells.	Triiodothyronine	0-16	cystatin C	Homo sapiens	28-38
22360852-2	2012	To study whether 3,3",5-triiodo-l-thyronine (T(3)) stimulates the production of cystatin C in vitro, we used a T(3)-responsive osteoblastic cell line (PyMS) which can be kept in serum-free culture.	Triiodothyronine	17-43	cystatin C	Homo sapiens	80-90
22360852-2	2012	To study whether 3,3",5-triiodo-l-thyronine (T(3)) stimulates the production of cystatin C in vitro, we used a T(3)-responsive osteoblastic cell line (PyMS) which can be kept in serum-free culture.	Triiodothyronine	45-49	cystatin C	Homo sapiens	80-90
22360852-2	2012	To study whether 3,3",5-triiodo-l-thyronine (T(3)) stimulates the production of cystatin C in vitro, we used a T(3)-responsive osteoblastic cell line (PyMS) which can be kept in serum-free culture.	Triiodothyronine	111-115	cystatin C	Homo sapiens	80-90
22360852-3	2012	We compared the effects of T(3) on cystatin C mRNA expression (by Northern) and on protein release (by Western and ELISA) with those of dexamethasone (dex).	Triiodothyronine	27-31	cystatin C	Homo sapiens	35-45
22360852-4	2012	Triiodothyronine increased cystatin C mRNA expression and cystatin C accumulation in culture media in a dose- and time-dependent manner, 1.5-fold at 1 nmol/l after 4d; dex (100 nmol/l) was more potent and increased cystatin C accumulation 3-fold after 4d.	Triiodothyronine	0-16	cystatin C	Homo sapiens	27-37
22360852-4	2012	Triiodothyronine increased cystatin C mRNA expression and cystatin C accumulation in culture media in a dose- and time-dependent manner, 1.5-fold at 1 nmol/l after 4d; dex (100 nmol/l) was more potent and increased cystatin C accumulation 3-fold after 4d.	Triiodothyronine	0-16	cystatin C	Homo sapiens	58-68
22360852-4	2012	Triiodothyronine increased cystatin C mRNA expression and cystatin C accumulation in culture media in a dose- and time-dependent manner, 1.5-fold at 1 nmol/l after 4d; dex (100 nmol/l) was more potent and increased cystatin C accumulation 3-fold after 4d.	Triiodothyronine	0-16	cystatin C	Homo sapiens	58-68
22360852-7	2012	Triiodothyronine-induced increase in the production of cystatin C may be related to an increased cell metabolism and proteolysis control demand.	Triiodothyronine	0-16	cystatin C	Homo sapiens	55-65
22490590-0	2012	Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations.	Triiodothyronine	168-185	nicotinamide phosphoribosyltransferase	Rattus norvegicus	17-25
22177412-9	2012	These facts explain several facts that have previously been empirically known: the affinity of liothyronine for the receptor is higher than that of thyroxine, the affinity of thyroxine for the transport proteins is higher than that of liothyronine and the selectivity of thyroxine for the OATP1C1 organic anion transporter is higher than that of liothyronine.	Triiodothyronine	95-107	solute carrier organic anion transporter family member 1C1	Homo sapiens	289-296
22227458-10	2012	When OPCs were cultured under differentiation condition (containing tri-iodothyronine, T3), blocking Nogo-A, OMgp or NgR could all inhibit the differentiation of OPCs, and this effect might involve the extracellular signal-regulated kinases1/2 (Erk1/2) signaling pathway.	Triiodothyronine	68-85	reticulon 4	Rattus norvegicus	101-107
21994129-4	2012	In this study, we demonstrate that T(3) may play a suppressor role by inducing DKK4 expression in HCC cells at both the messenger RNA (mRNA) and protein levels.	Triiodothyronine	35-39	dickkopf WNT signaling pathway inhibitor 4	Homo sapiens	79-83
22227458-10	2012	When OPCs were cultured under differentiation condition (containing tri-iodothyronine, T3), blocking Nogo-A, OMgp or NgR could all inhibit the differentiation of OPCs, and this effect might involve the extracellular signal-regulated kinases1/2 (Erk1/2) signaling pathway.	Triiodothyronine	68-85	oligodendrocyte-myelin glycoprotein	Rattus norvegicus	109-113
22227458-10	2012	When OPCs were cultured under differentiation condition (containing tri-iodothyronine, T3), blocking Nogo-A, OMgp or NgR could all inhibit the differentiation of OPCs, and this effect might involve the extracellular signal-regulated kinases1/2 (Erk1/2) signaling pathway.	Triiodothyronine	68-85	reticulon 4 receptor	Rattus norvegicus	117-120
22070540-6	2012	Recent evidence for a circadian-based molecular mechanism within the pars tuberalis of the pituitary, which ties the short duration melatonin signal reflecting long day length to the hypothalamic increase of triiodothyronine (T3) through a thyroid-stimulating hormone/deiodinase2 paracrine mechanism is presented and evaluated in this context.	Triiodothyronine	208-224	type II iodothyronine deiodinase	Ovis aries	268-279
22202165-11	2012	Finally, TRH mRNA levels in T(3)-treated hypothyroid PRCP(gt/gt) mice showed a non significant reduction compared with those of hypothyroid PRCP(gt/gt) mice, supporting the impairment of the hypothalamo-pituitary-thyroid axis in PRCP(gt/gt) mice.	Triiodothyronine	28-32	thyrotropin releasing hormone	Mus musculus	9-12
22202165-11	2012	Finally, TRH mRNA levels in T(3)-treated hypothyroid PRCP(gt/gt) mice showed a non significant reduction compared with those of hypothyroid PRCP(gt/gt) mice, supporting the impairment of the hypothalamo-pituitary-thyroid axis in PRCP(gt/gt) mice.	Triiodothyronine	28-32	prolylcarboxypeptidase (angiotensinase C)	Mus musculus	53-57
22166982-7	2012	The rise in T(3) with parenteral nutrition paralleled an increase of liver and kidney type-1 and a decrease of liver and kidney type-3 deiodinase activity and an increase in circulating and central leptin.	Triiodothyronine	12-16	leptin	Oryctolagus cuniculus	198-204
22070540-6	2012	Recent evidence for a circadian-based molecular mechanism within the pars tuberalis of the pituitary, which ties the short duration melatonin signal reflecting long day length to the hypothalamic increase of triiodothyronine (T3) through a thyroid-stimulating hormone/deiodinase2 paracrine mechanism is presented and evaluated in this context.	Triiodothyronine	226-228	type II iodothyronine deiodinase	Ovis aries	268-279
22500101-0	2012	Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells.	Triiodothyronine	0-16	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	27-33
21613298-6	2012	In addition, the dolphins showed reduced thyroid hormone levels and total thyroxine, free thyroxine and triiodothyronine negatively correlated with PCB concentration measured in blubber (p = 0.039, < 0.001, 0.009, respectively).	Triiodothyronine	104-120	pyruvate carboxylase	Homo sapiens	148-151
22382325-2	2012	Here we provide further evidence that these cofactors modulate the promoter activity of the nuclear receptor thyroid hormone receptor (TR) target gene, thyroid-stimulating hormone alpha (TSHalpha), which is negatively regulated by the TR ligand triiodothyronine (T(3)).	Triiodothyronine	245-261	glycoprotein hormones, alpha polypeptide	Homo sapiens	187-195
22382325-2	2012	Here we provide further evidence that these cofactors modulate the promoter activity of the nuclear receptor thyroid hormone receptor (TR) target gene, thyroid-stimulating hormone alpha (TSHalpha), which is negatively regulated by the TR ligand triiodothyronine (T(3)).	Triiodothyronine	263-267	glycoprotein hormones, alpha polypeptide	Homo sapiens	187-195
22973308-6	2012	Recent literature reports upon complex hypothalamic and peripheral interactions between T2DM and thyroid, and suggests T(3) to enhance cholesterol synthesis and to have a role in insulin resistance states.	Triiodothyronine	119-123	insulin	Homo sapiens	179-186
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	113-129	insulin like growth factor binding protein 6	Homo sapiens	45-52
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	113-129	bone gamma-carboxyglutamate protein	Homo sapiens	71-82
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	131-157	insulin like growth factor binding protein 6	Homo sapiens	45-52
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	131-157	bone gamma-carboxyglutamate protein	Homo sapiens	71-82
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	159-161	insulin like growth factor binding protein 6	Homo sapiens	45-52
21997736-9	2012	Moreover, real-time RT-PCR demonstrates that IGFBP-6 could inhibit the osteocalcin mRNA transcription induced by Triiodothyronine (3,3",5-Triiodo-L-thyronine, T3) in osteoblastic cells.	Triiodothyronine	159-161	bone gamma-carboxyglutamate protein	Homo sapiens	71-82
22075692-0	2012	Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes.	Triiodothyronine	0-16	uncoupling protein 1	Homo sapiens	25-30
22075692-7	2012	In this study, triiodothyronine (T(3)) treatment induced UCP-1 expression and mitochondrial biogenesis, accompanied by the induction of the CCAAT/enhancer binding protein, peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and nuclear respiratory factor-1 in differentiated human multipotent adipose-derived stem cells.	Triiodothyronine	15-31	uncoupling protein 1	Homo sapiens	57-62
22075692-7	2012	In this study, triiodothyronine (T(3)) treatment induced UCP-1 expression and mitochondrial biogenesis, accompanied by the induction of the CCAAT/enhancer binding protein, peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and nuclear respiratory factor-1 in differentiated human multipotent adipose-derived stem cells.	Triiodothyronine	33-37	uncoupling protein 1	Homo sapiens	57-62
22075692-10	2012	These findings indicate that T(3) is an active modulator, which induces energy utilization in white adipocytes through the regulation of UCP-1 expression and mitochondrial biogenesis.	Triiodothyronine	29-33	uncoupling protein 1	Homo sapiens	137-142
21974928-6	2012	Evidence that elevated T(3) augmented the maturation rate of cardiomyocytes included 14% increased width, 31% increase in binucleation, 39% reduction in proliferation, 150% reduction in cyclin D1 protein, and 500% increase in p21 protein.	Triiodothyronine	23-27	G1/S-specific cyclin-D1	Ovis aries	186-195
21974928-7	2012	Increased expression of phospho-mTOR, ANP, and SERCA2a also suggests that T(3) promotes maturation and hypertrophy of fetal cardiomyocytes.	Triiodothyronine	74-78	serine/threonine-protein kinase mTOR	Ovis aries	32-36
23011135-4	2012	Imprinting training in chicks causes rapid inflow of T(3), converted from circulating plasma thyroxine by Dio2, type 2 iodothyronine deiodinase, in brain vascular endothelial cells.	Triiodothyronine	53-57	iodothyronine deiodinase 2	Homo sapiens	106-110
23011135-4	2012	Imprinting training in chicks causes rapid inflow of T(3), converted from circulating plasma thyroxine by Dio2, type 2 iodothyronine deiodinase, in brain vascular endothelial cells.	Triiodothyronine	53-57	iodothyronine deiodinase 2	Homo sapiens	112-143
22966413-2	2012	The expression of P450R and iNOS is regulated by triiodothyronine.	Triiodothyronine	49-65	cytochrome p450 oxidoreductase	Rattus norvegicus	18-23
22966413-2	2012	The expression of P450R and iNOS is regulated by triiodothyronine.	Triiodothyronine	49-65	nitric oxide synthase 2	Rattus norvegicus	28-32
22649286-1	2012	L-3,3",5-triiodothyronine (T(3)) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection.	Triiodothyronine	0-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
22768225-3	2012	We tested for the presence of the CTR in chondrocytes from tri-iodothyronin (T3)-induced bovine articular cartilage explants.	Triiodothyronine	77-79	calcitonin receptor	Homo sapiens	34-37
22649286-1	2012	L-3,3",5-triiodothyronine (T(3)) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection.	Triiodothyronine	27-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
22649286-7	2012	Under these conditions, T(3)-induced tumor necrosis factor-alpha (TNF-alpha) response was eliminated by previous GdCl(3) administration.	Triiodothyronine	24-28	tumor necrosis factor	Rattus norvegicus	37-64
22649286-7	2012	Under these conditions, T(3)-induced tumor necrosis factor-alpha (TNF-alpha) response was eliminated by previous GdCl(3) administration.	Triiodothyronine	24-28	tumor necrosis factor	Rattus norvegicus	66-75
22649286-9	2012	It is concluded that Kupffer cell functioning is essential for upregulation of liver Nrf2-signaling pathway by T(3).	Triiodothyronine	111-115	NFE2 like bZIP transcription factor 2	Rattus norvegicus	85-89
21771965-0	2011	Type II iodothyronine deiodinase provides intracellular 3,5,3"-triiodothyronine to normal and regenerating mouse skeletal muscle.	Triiodothyronine	56-79	deiodinase, iodothyronine, type II	Mus musculus	0-32
21952246-6	2011	Measured at initial rate and at the body/rearing temperature of zebrafish (26 C), T(3) uptake by zebrafish Slc16a2 is a saturable process with a calculated Michaelis-Menten constant of 0.8 muM T(3).	Triiodothyronine	82-86	solute carrier family 16 member 2	Danio rerio	107-114
21952246-9	2011	This implies that at a normal body temperature in zebrafish, Slc16a2 protein is predominantly involved in T(3) uptake.	Triiodothyronine	106-110	solute carrier family 16 member 2	Danio rerio	61-68
21952246-14	2011	We suggest that Slc16a2 plays a key role in the local availability of T(3) in adult tissues as well as during the completion of morphogenesis of primary organ systems.	Triiodothyronine	70-74	solute carrier family 16 member 2	Danio rerio	16-23
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	94-110	solute carrier family 2 member 4	Rattus norvegicus	12-33
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	94-110	solute carrier family 2 member 4	Rattus norvegicus	35-40
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	94-110	solute carrier family 2 member 4	Rattus norvegicus	126-190
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	94-110	solute carrier family 2 member 4	Rattus norvegicus	192-198
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	112-116	solute carrier family 2 member 4	Rattus norvegicus	12-33
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	112-116	solute carrier family 2 member 4	Rattus norvegicus	35-40
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	112-116	solute carrier family 2 member 4	Rattus norvegicus	126-190
22136156-1	2012	BACKGROUND: Glucose transporter 4 (GLUT4) is highly expressed in muscle and fat tissue, where triiodothyronine (T(3)) induces solute carrier family 2 facilitated glucose transporter member 4 (SLC2A4) gene transcription.	Triiodothyronine	112-116	solute carrier family 2 member 4	Rattus norvegicus	192-198
22142372-1	2012	BACKGROUND: The type 2 deiodinase gene (DIO2) encodes a deiodinase that converts the thyroid prohormone, thyroxine, to the biologically active triiodothyronine.	Triiodothyronine	143-159	iodothyronine deiodinase 2	Homo sapiens	40-44
21685153-2	2011	Using preclinical models of acute lung injury (ALI), we assessed the gene and protein expression of type 2 deiodinase (DIO2), a key driver for synthesis of biologically active triiodothyronine, and addressed potential association of DIO2 genetic variants with ALI in a multiethnic cohort.	Triiodothyronine	176-192	deiodinase, iodothyronine, type II	Mus musculus	119-123
21030056-0	2011	Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension.	Triiodothyronine	88-92	endothelin 1	Gallus gallus	19-31
21840963-1	2011	We previously reported that the 3,5,3"-triiodo-L-thyronine (T3)-induced increase of Na-K-ATPase activity in rat alveolar epithelial cells (AECs) required activation of Src kinase, PI3K, and MAPK/ERK1/2.	Triiodothyronine	60-62	mitogen activated protein kinase 3	Rattus norvegicus	195-201
21771965-1	2011	The FoxO3-dependent increase in type II deiodinase (D2), which converts the prohormone thyroxine (T(4)) to 3,5,3"-triiodothyronine (T(3)), is required for normal mouse skeletal muscle differentiation and regeneration.	Triiodothyronine	107-130	forkhead box O3	Mus musculus	4-9
21771965-1	2011	The FoxO3-dependent increase in type II deiodinase (D2), which converts the prohormone thyroxine (T(4)) to 3,5,3"-triiodothyronine (T(3)), is required for normal mouse skeletal muscle differentiation and regeneration.	Triiodothyronine	132-136	forkhead box O3	Mus musculus	4-9
21584707-1	2011	BACKGROUND: Tri-iodothyronine (T3) has been shown to be a hepatic mitogen.	Triiodothyronine	31-33	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	12-15
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	92-108	solute carrier family 16 member 2	Homo sapiens	15-44
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	92-108	solute carrier family 16 member 2	Homo sapiens	46-50
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	92-108	solute carrier family 16 member 2	Homo sapiens	52-59
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	110-115	solute carrier family 16 member 2	Homo sapiens	15-44
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	110-115	solute carrier family 16 member 2	Homo sapiens	46-50
21896621-1	2011	OBJECTIVE: The monocarboxylate transporter 8 (MCT8; SLC16A2) has a pivotal role in neuronal triiodothyronine (T(3)) uptake.	Triiodothyronine	110-115	solute carrier family 16 member 2	Homo sapiens	52-59
21896621-3	2011	We describe the genetic analysis of the MCT8 gene in a patient suspected for AHDS and the clinical and endocrine effects of L-thyroxine (LT(4)) or liothyronine (LT(3)) treatment intending to overcome the T(3) uptake resistance through alternative transporters.	Triiodothyronine	147-159	solute carrier family 16 member 2	Homo sapiens	40-44
21896621-3	2011	We describe the genetic analysis of the MCT8 gene in a patient suspected for AHDS and the clinical and endocrine effects of L-thyroxine (LT(4)) or liothyronine (LT(3)) treatment intending to overcome the T(3) uptake resistance through alternative transporters.	Triiodothyronine	162-166	solute carrier family 16 member 2	Homo sapiens	40-44
21896621-8	2011	MCT8 dysfunction was associated with partial resistance to T(3) at the hypothalamus and pituitary level, with normal responsiveness at the peripheral organs (liver and cardiovascular system).	Triiodothyronine	59-63	solute carrier family 16 member 2	Homo sapiens	0-4
22295623-5	2011	Additionally, there were significant positive correlation between BDE-28, -47 and triiodothyronine (T3), as well as between BDE-28, -153, -183 and free triiodothyronine(fT3).	Triiodothyronine	152-168	homeobox D13	Homo sapiens	124-127
21679771-5	2011	In ovo leptin administration markedly accelerated early posthatch growth, elevated serum levels of total and free triiodothyronine (tT3 and fT3), while that of total thyroxin (tT4) remained unchanged.	Triiodothyronine	114-130	leptin	Gallus gallus	7-13
21605865-6	2011	Sera from T(3)-treated rats stimulated efflux via ABCA1 but not by ABCG1 or SR-BI.	Triiodothyronine	10-14	ATP binding cassette subfamily A member 1	Rattus norvegicus	50-55
21798688-10	2011	Triiodothyronine decreased basal STAR and CYP11A1 mRNAs in F3 follicles, increased them in F1 follicles, and elevated HSD3B mRNA levels in F1 follicles.	Triiodothyronine	0-16	steroidogenic acute regulatory protein	Gallus gallus	33-37
21798688-10	2011	Triiodothyronine decreased basal STAR and CYP11A1 mRNAs in F3 follicles, increased them in F1 follicles, and elevated HSD3B mRNA levels in F1 follicles.	Triiodothyronine	0-16	cytochrome P450 family 11 subfamily A member 1	Gallus gallus	42-49
21798688-11	2011	Triiodothyronine augmented LH-stimulated STAR, CYP11A1, and HSD3B mRNA levels in F2 and CYP11A1 in F1 follicles.	Triiodothyronine	0-16	steroidogenic acute regulatory protein	Gallus gallus	41-45
21798688-11	2011	Triiodothyronine augmented LH-stimulated STAR, CYP11A1, and HSD3B mRNA levels in F2 and CYP11A1 in F1 follicles.	Triiodothyronine	0-16	cytochrome P450 family 11 subfamily A member 1	Gallus gallus	47-54
21798688-11	2011	Triiodothyronine augmented LH-stimulated STAR, CYP11A1, and HSD3B mRNA levels in F2 and CYP11A1 in F1 follicles.	Triiodothyronine	0-16	cytochrome P450 family 11 subfamily A member 1	Gallus gallus	88-95
21943743-2	2011	Organ-specific changes in production of triiodothyronine from its prohormone, thyroxine, have been hypothesized to target the action of thyroid hormones on the mammary gland and play a role in mediating or augmenting a galactopoietic response to bovine somatotropin (bST).	Triiodothyronine	40-56	somatotropin	Bos taurus	253-265
21798688-0	2011	Effect of 3,3",5-triiodothyronine and 3,5-diiodothyronine on progesterone production, cAMP synthesis, and mRNA expression of STAR, CYP11A1, and HSD3B genes in granulosa layer of chicken preovulatory follicles.	Triiodothyronine	10-33	steroidogenic acute regulatory protein	Gallus gallus	125-129
21813593-0	2011	Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.	Triiodothyronine	89-105	solute carrier family 16 member 2	Homo sapiens	0-29
21813593-2	2011	Mutations in MCT8 (or SLC16A2) lead to a severe form of X-linked psychomotor retardation, which is characterised by elevated plasma triiodothyronine (T(3)) and low/normal thyroxine (T(4)).	Triiodothyronine	132-148	solute carrier family 16 member 2	Homo sapiens	13-17
21813593-2	2011	Mutations in MCT8 (or SLC16A2) lead to a severe form of X-linked psychomotor retardation, which is characterised by elevated plasma triiodothyronine (T(3)) and low/normal thyroxine (T(4)).	Triiodothyronine	132-148	solute carrier family 16 member 2	Homo sapiens	22-29
21605865-7	2011	Gel filtration chromatography revealed that T(3) treatment caused a decrease in HDL particle size accompanied by higher levels of lipid-poor ApoA-I.	Triiodothyronine	44-48	apolipoprotein A1	Rattus norvegicus	141-147
21605865-9	2011	This effect is most likely attributable to increases in small HDL and lipid poor ApoA-I in response to T(3).	Triiodothyronine	103-107	apolipoprotein A1	Rattus norvegicus	81-87
21550628-4	2011	TBBPA, TCBPA, and 3,3",5-triClBPA inhibited the binding of triiodothyronine (T3) to TRalpha at 2x10(-5) M without rat liver S9 treatment and 4x10(-6) M with rat liver S9 treatment, demonstrating their T3 antagonist activity.	Triiodothyronine	77-79	T cell receptor alpha locus	Homo sapiens	84-91
21262066-8	2011	On day 60, urinary iodine correlated with C-reactive protein (r 0 461, P = 0 018), and free triiodothyronine correlated with IL-6 (r - 0 429, P = 0 025).	Triiodothyronine	92-108	interleukin 6	Homo sapiens	125-129
21508094-8	2011	The addition of T(2) or T(3) to lipid-overloaded cells resulted in i) reduction in lipid content; ii) downregulation of PPARalpha, PPARgamma, and AOX expression; iii) increase in PPARdelta expression; and iv) stimulation of mitochondrial uncoupling.	Triiodothyronine	24-28	peroxisome proliferator activated receptor alpha	Rattus norvegicus	120-129
21508094-8	2011	The addition of T(2) or T(3) to lipid-overloaded cells resulted in i) reduction in lipid content; ii) downregulation of PPARalpha, PPARgamma, and AOX expression; iii) increase in PPARdelta expression; and iv) stimulation of mitochondrial uncoupling.	Triiodothyronine	24-28	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	131-140
21508094-8	2011	The addition of T(2) or T(3) to lipid-overloaded cells resulted in i) reduction in lipid content; ii) downregulation of PPARalpha, PPARgamma, and AOX expression; iii) increase in PPARdelta expression; and iv) stimulation of mitochondrial uncoupling.	Triiodothyronine	24-28	acyl-CoA oxidase 1	Rattus norvegicus	146-149
21550628-4	2011	TBBPA, TCBPA, and 3,3",5-triClBPA inhibited the binding of triiodothyronine (T3) to TRalpha at 2x10(-5) M without rat liver S9 treatment and 4x10(-6) M with rat liver S9 treatment, demonstrating their T3 antagonist activity.	Triiodothyronine	59-75	T cell receptor alpha locus	Homo sapiens	84-91
21835056-5	2011	One of the most important findings was the identification of a specific transporter for triiodothyronine (T3), the monocarboxylate transporter 8 (MCT8) responsible for directed transport of T3 into target cells and for export of thyroid hormones out of thyroid epithelial cells.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	115-144
21835056-5	2011	One of the most important findings was the identification of a specific transporter for triiodothyronine (T3), the monocarboxylate transporter 8 (MCT8) responsible for directed transport of T3 into target cells and for export of thyroid hormones out of thyroid epithelial cells.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	146-150
21551267-7	2011	After a T(3) suppression test, we found a blunted response of liver Gsta after the lower doses of T(3) in homozygous animals, as expected.	Triiodothyronine	8-12	glutathione S-transferase cluster	Mus musculus	68-72
21551267-7	2011	After a T(3) suppression test, we found a blunted response of liver Gsta after the lower doses of T(3) in homozygous animals, as expected.	Triiodothyronine	98-102	glutathione S-transferase cluster	Mus musculus	68-72
21442762-0	2011	Role of FSH and triiodothyronine in Sertoli cell development expressed by formation of connexin 43-based gap junctions.	Triiodothyronine	16-32	gap junction protein, alpha 1	Rattus norvegicus	87-98
21557150-3	2011	The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats.	Triiodothyronine	43-47	leptin	Rattus norvegicus	110-116
21389087-1	2011	We previously showed that two thyroid hormone receptor (TR) isoforms--TRalpha1 and TRbeta1--differentially regulate thyroid hormone (triiodothyroxine, T(3))-stimulated adipogenesis in vivo.	Triiodothyronine	151-156	thyroid hormone receptor alpha	Mus musculus	70-78
21389087-3	2011	We found that T(3)-stimulated adipogenesis of 3T3-L1 cells was accompanied by progressive loss of NCoR1 protein levels.	Triiodothyronine	14-18	nuclear receptor co-repressor 1	Mus musculus	98-103
21406615-8	2011	Interestingly, POMC-Ptp1b(-/-) mice had increased BAT weight and elevated plasma triiodothyronine (T(3)) levels in response to a 4-day cold challenge, as well as reduced SPA 24 h after cold exposure, relative to controls.	Triiodothyronine	81-97	pro-opiomelanocortin-alpha	Mus musculus	15-19
21406615-8	2011	Interestingly, POMC-Ptp1b(-/-) mice had increased BAT weight and elevated plasma triiodothyronine (T(3)) levels in response to a 4-day cold challenge, as well as reduced SPA 24 h after cold exposure, relative to controls.	Triiodothyronine	81-97	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	20-25
21406615-8	2011	Interestingly, POMC-Ptp1b(-/-) mice had increased BAT weight and elevated plasma triiodothyronine (T(3)) levels in response to a 4-day cold challenge, as well as reduced SPA 24 h after cold exposure, relative to controls.	Triiodothyronine	99-103	pro-opiomelanocortin-alpha	Mus musculus	15-19
21406615-8	2011	Interestingly, POMC-Ptp1b(-/-) mice had increased BAT weight and elevated plasma triiodothyronine (T(3)) levels in response to a 4-day cold challenge, as well as reduced SPA 24 h after cold exposure, relative to controls.	Triiodothyronine	99-103	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	20-25
21557150-0	2011	Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats.	Triiodothyronine	19-35	leptin	Rattus norvegicus	51-57
21458529-1	2011	Thyroid hormone (T3) suppresses cerebral gene expression of the beta-amyloid precursor protein (APP), an integral membrane protein that plays a key role in the onset and progression of Alzheimer"s disease.	Triiodothyronine	17-19	amyloid beta precursor protein	Rattus norvegicus	64-94
21458530-4	2011	T(3) administration in rat kidneys induced HO-1 expression in a time-dependent and dose-dependent way, and its expression was accompanied with significant depletion of reduced glutathione and increase in malondialdehyde content, showing a moderate oxidative stress that turns to normal level 48 h after drug injection.	Triiodothyronine	0-4	heme oxygenase 1	Rattus norvegicus	43-47
21458530-6	2011	In conclusion, T(3) administration involving oxidative stress in kidney exerts significant enhancement of HO-1 expression which may, at least in part, account for the renal preconditioning induced by T(3).	Triiodothyronine	15-19	heme oxygenase 1	Rattus norvegicus	106-110
21458530-6	2011	In conclusion, T(3) administration involving oxidative stress in kidney exerts significant enhancement of HO-1 expression which may, at least in part, account for the renal preconditioning induced by T(3).	Triiodothyronine	200-204	heme oxygenase 1	Rattus norvegicus	106-110
21557150-3	2011	The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats.	Triiodothyronine	43-47	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	132-143
21557150-0	2011	Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats.	Triiodothyronine	19-35	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	62-73
21563917-2	2011	The aim of this study was to evaluate the hypothesis that in vivo T(3) administration triggers a redox-mediated translocation of the cytoprotective nuclear transcription factor erythroid 2-related factor 2 (Nrf2) from the cytosol to the nucleus in rat liver.	Triiodothyronine	66-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	207-211
21292729-2	2011	Conversion of T(4) to T(3) is catalyzed by the type 2 iodothyronine deiodinase enzyme (DIO2), and T(3) action in target tissues is determined by DIO2-regulated local availability of T(3) to its nuclear receptors, TRalpha and TRbeta.	Triiodothyronine	22-26	deiodinase, iodothyronine, type II	Mus musculus	87-91
21563917-4	2011	MATERIALS AND METHODS: The effect of T(3) administration in the presence and absence of N-acetylcysteine (NAC) on cytosol-to-nuclear translocation of Nrf2 was evaluated, with inhibition of this process by NAC taken as evidence that the process was redox mediated.	Triiodothyronine	37-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
21563917-9	2011	RESULTS: T(3) administration induced a significant increase in the hepatic nuclear levels of Nrf2 at 1 and 2 hours after treatment and a concomitant decrease in cytosolic Nrf2.	Triiodothyronine	9-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
21563917-9	2011	RESULTS: T(3) administration induced a significant increase in the hepatic nuclear levels of Nrf2 at 1 and 2 hours after treatment and a concomitant decrease in cytosolic Nrf2.	Triiodothyronine	9-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
21563917-14	2011	In the group of rats pretreated with NAC, the increase in cytosol-to-nuclear translocation of Nrf2 was only 28% that induced by T(3).	Triiodothyronine	128-132	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
21563917-15	2011	In addition, T(3) induced liver Akt and p38 activation during the period of 1-4 hours after T(3) administration.	Triiodothyronine	13-17	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
21563917-15	2011	In addition, T(3) induced liver Akt and p38 activation during the period of 1-4 hours after T(3) administration.	Triiodothyronine	13-17	mitogen activated protein kinase 14	Rattus norvegicus	40-43
21563917-16	2011	p38 activation at 2 hours after T(3) administration was abolished in NAC-pretreated animals.	Triiodothyronine	32-36	mitogen activated protein kinase 14	Rattus norvegicus	0-3
21563917-17	2011	CONCLUSIONS: In vivo T(3) administration leads to a rapid and transient cytosol-to-nuclear translocation of liver Nrf2.	Triiodothyronine	21-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-118
21563917-20	2011	Nrf2 cytosol-to-nuclear translocation may represent a novel cytoprotective mechanism of T(3) to limit free radical or electrophile toxicity, as this would likely entail promoting thioredoxin production.	Triiodothyronine	88-92	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
21563917-20	2011	Nrf2 cytosol-to-nuclear translocation may represent a novel cytoprotective mechanism of T(3) to limit free radical or electrophile toxicity, as this would likely entail promoting thioredoxin production.	Triiodothyronine	88-92	thioredoxin 1	Rattus norvegicus	179-190
21427224-4	2011	In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction.	Triiodothyronine	6-8	bone gamma-carboxyglutamate protein 2	Mus musculus	120-131
21385076-6	2011	SUMMARY: The acute onset of severe thyroid pain, rapid increase in serum Free Thyroxine Index, and thyroglobulin concentrations with a triiodothyronine to free thyroxine index ratio of < 20 to 1 were compatible with an acute onset destructive thyroiditis, likely related to direct toxicity from the iodinated contrast material.	Triiodothyronine	135-151	thyroglobulin	Homo sapiens	99-112
21217776-12	2011	Our results show that T(3)-mediated upregulation of CTSH led to matrix metallopeptidase or extracellular signal-regulated kinase activation and increased cell migration.	Triiodothyronine	22-26	cathepsin H	Mus musculus	52-56
21511232-4	2011	In 2005 we reported the first mutations in the SBP2 gene in two families in which the probands presented with transient growth retardation associated with abnormal thyroid function tests, low triiodothyronine (T3), high thyroxine (T4) and reverse T3, and slightly elevated thyrotropin.	Triiodothyronine	192-208	SECIS binding protein 2	Homo sapiens	47-51
21529443-4	2011	The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay.	Triiodothyronine	76-92	insulin like growth factor binding protein 3	Homo sapiens	14-21
21529443-4	2011	The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay.	Triiodothyronine	76-92	growth hormone 1	Homo sapiens	29-43
21529443-4	2011	The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay.	Triiodothyronine	94-96	insulin like growth factor binding protein 3	Homo sapiens	14-21
21529443-4	2011	The effect of IGFBP-3 on the growth hormone promoter activity stimulated by triiodothyronine (T3) was determined by dual-luciferase reporter assay.	Triiodothyronine	94-96	growth hormone 1	Homo sapiens	29-43
21735607-1	2010	Upon binding of the ligand triiodothyronine (T3), TR undergoes a conformational change that releases corepressors and recruits coactivators, such as Steroid Receptor Coactivator 2 (SRC2); in turn, these modulate the expression of target genes.	Triiodothyronine	27-43	nuclear receptor coactivator 2	Homo sapiens	149-179
21735607-1	2010	Upon binding of the ligand triiodothyronine (T3), TR undergoes a conformational change that releases corepressors and recruits coactivators, such as Steroid Receptor Coactivator 2 (SRC2); in turn, these modulate the expression of target genes.	Triiodothyronine	27-43	nuclear receptor coactivator 2	Homo sapiens	181-185
21735607-1	2010	Upon binding of the ligand triiodothyronine (T3), TR undergoes a conformational change that releases corepressors and recruits coactivators, such as Steroid Receptor Coactivator 2 (SRC2); in turn, these modulate the expression of target genes.	Triiodothyronine	45-47	nuclear receptor coactivator 2	Homo sapiens	181-185
21735607-1	2010	Upon binding of the ligand triiodothyronine (T3), TR undergoes a conformational change that releases corepressors and recruits coactivators, such as Steroid Receptor Coactivator 2 (SRC2); in turn, these modulate the expression of target genes.	Triiodothyronine	45-47	nuclear receptor coactivator 2	Homo sapiens	149-179
21285310-4	2011	Adding D1 deficiency to that of Mct8 corrected the serum TH abnormalities of Mct8KO mice, normalized brain T(3) content, and reduced the impaired expression of TH-responsive genes.	Triiodothyronine	107-111	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	32-36
21323585-1	2011	BACKGROUND: Type 2 iodothyronine deiodinase (D2) is an enzyme that catalyzes the production of triiodothyronine (T3) from thyroxine (T4) and plays a critical role in providing the local intracellular T3.	Triiodothyronine	95-111	iodothyronine deiodinase 2	Homo sapiens	12-43
21264952-11	2011	Pharmacological inhibition of L-type amino acid transporters by BCH and genetic inactivation of Lat2 reduced astrocytic T(3) uptake to the same extent.	Triiodothyronine	120-124	linker for activation of T cells family, member 2	Mus musculus	96-100
21264952-12	2011	BSP, a broad spectrum inhibitor, including Mct8, reduced T(3) uptake further suggesting the cooperative activity of several T(3) transporters in astrocytes.	Triiodothyronine	57-61	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	43-47
21106438-9	2011	A doubling of BDE-154 was associated with 0.043 ng/mL lower triiodothyronine (T3) values (adjusted r=-0.245, p=0.043).	Triiodothyronine	60-76	homeobox D13	Homo sapiens	14-17
21106438-9	2011	A doubling of BDE-154 was associated with 0.043 ng/mL lower triiodothyronine (T3) values (adjusted r=-0.245, p=0.043).	Triiodothyronine	78-80	homeobox D13	Homo sapiens	14-17
21468567-2	2011	We previously revealed that triiodothyronine (T3)-activated p38 mitogen-activated protein (MAP) kinase, but not p44/p42 MAP kinase, is involved in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	28-44	bone gamma-carboxyglutamate protein 2	Mus musculus	164-175
21468567-2	2011	We previously revealed that triiodothyronine (T3)-activated p38 mitogen-activated protein (MAP) kinase, but not p44/p42 MAP kinase, is involved in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	46-48	bone gamma-carboxyglutamate protein 2	Mus musculus	164-175
21239609-3	2011	Here we show that the thyroid hormone (T3) produces a rapid increase in histone H3Ser10 phosphorylation (H3Ser10ph) concomitant to the rapid displacement of the heterochromatin protein 1beta (HP1beta) to the nuclear periphery.	Triiodothyronine	39-41	chromobox 1	Homo sapiens	161-190
21239609-3	2011	Here we show that the thyroid hormone (T3) produces a rapid increase in histone H3Ser10 phosphorylation (H3Ser10ph) concomitant to the rapid displacement of the heterochromatin protein 1beta (HP1beta) to the nuclear periphery.	Triiodothyronine	39-41	chromobox 1	Homo sapiens	192-199
21323585-1	2011	BACKGROUND: Type 2 iodothyronine deiodinase (D2) is an enzyme that catalyzes the production of triiodothyronine (T3) from thyroxine (T4) and plays a critical role in providing the local intracellular T3.	Triiodothyronine	113-115	iodothyronine deiodinase 2	Homo sapiens	12-43
21468521-5	2011	These data reinforce the concept that the role of MCT8 is tissue-dependent: while neurons are highly dependent on MCT8, bone tissue, adipose tissue, muscle, and liver are less dependent on MCT8 and, therefore, may suffer the consequences of the exposition to high serum T3 levels.	Triiodothyronine	270-272	solute carrier family 16 member 2	Homo sapiens	50-54
21687413-9	2011	Since peptide mimetics have been used to disrupt essential protein interactions of the chlamydial T3S system and inhibit T3S-mediated invasion of HeLa cells, we hypothesized that if CdsL-CdsN binding is essential for regulating T3S then a CdsN peptide mimetic could be used to potentially block T3S and chlamydial invasion.	Triiodothyronine	98-101	corneodesmosin	Homo sapiens	187-191
21687413-9	2011	Since peptide mimetics have been used to disrupt essential protein interactions of the chlamydial T3S system and inhibit T3S-mediated invasion of HeLa cells, we hypothesized that if CdsL-CdsN binding is essential for regulating T3S then a CdsN peptide mimetic could be used to potentially block T3S and chlamydial invasion.	Triiodothyronine	121-124	corneodesmosin	Homo sapiens	187-191
21687413-9	2011	Since peptide mimetics have been used to disrupt essential protein interactions of the chlamydial T3S system and inhibit T3S-mediated invasion of HeLa cells, we hypothesized that if CdsL-CdsN binding is essential for regulating T3S then a CdsN peptide mimetic could be used to potentially block T3S and chlamydial invasion.	Triiodothyronine	121-124	corneodesmosin	Homo sapiens	239-243
20937391-0	2011	The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition.	Triiodothyronine	25-44	transthyretin	Homo sapiens	62-75
20937391-3	2011	In the present study, we characterized the interactions of the synthetic triiodo L-thyronine analogs and thyroid hormone nuclear receptor TRbeta-selective agonists GC-1 and GC-24 with the wild type and V30M variant of human transthyretin (TTR).	Triiodothyronine	73-92	transthyretin	Homo sapiens	224-237
21232100-5	2011	The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified.	Triiodothyronine	120-136	growth hormone 1	Homo sapiens	71-73
21318144-9	2011	Pearson"s correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels.	Triiodothyronine	90-106	insulin	Homo sapiens	36-43
21318144-9	2011	Pearson"s correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels.	Triiodothyronine	108-110	insulin	Homo sapiens	36-43
21232100-5	2011	The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified.	Triiodothyronine	120-136	insulin like growth factor 1	Homo sapiens	168-173
21232100-5	2011	The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified.	Triiodothyronine	138-140	growth hormone 1	Homo sapiens	71-73
21232100-5	2011	The relationship between GH secretion and thyroid function, as well as GH influence on the peripheral thyroxine (T4) to triiodothyronine (T3) deiodination, mediated by IGF-I, were identified.	Triiodothyronine	138-140	insulin like growth factor 1	Homo sapiens	168-173
22178948-2	2011	We describe differences in the regulation of UCP-1 mRNA expression between rat and mouse brown adipocytes in culture, using norepinephrine (NE), triiodothyronine (T3), insulin and retinoic acid (RA).	Triiodothyronine	145-161	uncoupling protein 1	Rattus norvegicus	45-50
20937676-3	2011	Our objective was to evaluate the contribution of type 1 and type 2 iodothyronine deiodinase (D1 (or DIO1) and D2 (or DIO2) respectively) in the thyroid gland to the high serum T(3) level in T(3)-P-GD.	Triiodothyronine	177-181	iodothyronine deiodinase 2	Homo sapiens	50-92
20937676-3	2011	Our objective was to evaluate the contribution of type 1 and type 2 iodothyronine deiodinase (D1 (or DIO1) and D2 (or DIO2) respectively) in the thyroid gland to the high serum T(3) level in T(3)-P-GD.	Triiodothyronine	177-181	iodothyronine deiodinase 1	Homo sapiens	101-105
20937676-3	2011	Our objective was to evaluate the contribution of type 1 and type 2 iodothyronine deiodinase (D1 (or DIO1) and D2 (or DIO2) respectively) in the thyroid gland to the high serum T(3) level in T(3)-P-GD.	Triiodothyronine	177-181	iodothyronine deiodinase 2	Homo sapiens	118-122
20628263-8	2011	Using a multiple linear regression analysis, serum IL-1beta was significantly associated with free thyroxine, sIL-2R with triiodothyronine and serum thyrotropin receptor antibody (TRAb) and TNF-alpha with TRAb.	Triiodothyronine	122-138	interleukin 1 beta	Homo sapiens	51-59
20932836-4	2011	We have shown that Cx43 is expressed in the Sertoli cells of rainbow trout and that cAMP and triiodothyronine (T(3)) regulate testicular Cx43 expression in brook trout testis.	Triiodothyronine	93-109	gap junction alpha-1 protein	Oncorhynchus mykiss	137-141
20932836-4	2011	We have shown that Cx43 is expressed in the Sertoli cells of rainbow trout and that cAMP and triiodothyronine (T(3)) regulate testicular Cx43 expression in brook trout testis.	Triiodothyronine	111-115	gap junction alpha-1 protein	Oncorhynchus mykiss	137-141
20932836-5	2011	The objective of this study was to determine if cAMP and T(3) act at the level of the cx43 promoter to regulate its expression.	Triiodothyronine	57-61	gap junction alpha-1 protein	Oncorhynchus mykiss	86-90
20844001-5	2010	By using two human cell lines, i.e., the thyroid HTori and the cervical cancer HeLa cell lines, each stably expressing TRbeta, we observed that T(3) induced the down-regulation of CTNNB1 transcript levels.	Triiodothyronine	144-148	T cell receptor beta locus	Homo sapiens	119-125
22163049-5	2011	When exposed to 10 nM 3,5,3"-triiodothyronine (T(3)), premetamorphic Trans(ING2) tadpoles exhibited a greater reduction in tail, head, and brain areas, and a protrusion of the lower jaw than T(3)-treated Trans(GFP) tadpoles.	Triiodothyronine	22-45	inhibitor of growth family member 2 L homeolog	Xenopus laevis	75-79
22163049-5	2011	When exposed to 10 nM 3,5,3"-triiodothyronine (T(3)), premetamorphic Trans(ING2) tadpoles exhibited a greater reduction in tail, head, and brain areas, and a protrusion of the lower jaw than T(3)-treated Trans(GFP) tadpoles.	Triiodothyronine	47-51	inhibitor of growth family member 2 L homeolog	Xenopus laevis	75-79
22163049-10	2011	Examination of endogenous T(3)-responsive promoters (TRbeta and TH/bZIP) in the tail by chromatin immunoprecipitation assays showed that ING proteins were recruited to TRE-containing regions in T(3)-dependent and independent ways, respectively.	Triiodothyronine	26-30	thyroid hormone receptor, beta S homeolog	Xenopus laevis	53-59
21701583-6	2011	Down-regulation of endogenous SHP-2 led to impairment of oligodendrocytes maturation and this effect was triiodo-L-thyronine (T3) dependent.	Triiodothyronine	105-124	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	30-35
21701583-6	2011	Down-regulation of endogenous SHP-2 led to impairment of oligodendrocytes maturation and this effect was triiodo-L-thyronine (T3) dependent.	Triiodothyronine	126-128	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	30-35
20580649-3	2010	Mice heterozygous for the TRalpha1 allele (TRalpha1+/m), yielding a receptor protein with a 10-fold reduced affinity to triiodothyronine (T3), and wildtype (wt) mice were subjected to several paradigms specifically testing depressive and anxious behaviour.	Triiodothyronine	138-140	thyroid hormone receptor alpha	Mus musculus	26-34
21912701-1	2011	Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3",5-triiodothyronine (T3), important regulator of cell proliferation and differentiation.	Triiodothyronine	143-145	iodothyronine deiodinase 1	Homo sapiens	33-37
20634638-0	2010	Free triiodothyronine is associated with smoking habit, independently of obesity, body fat distribution, insulin, and metabolic parameters.	Triiodothyronine	5-21	insulin	Homo sapiens	105-112
20844001-5	2010	By using two human cell lines, i.e., the thyroid HTori and the cervical cancer HeLa cell lines, each stably expressing TRbeta, we observed that T(3) induced the down-regulation of CTNNB1 transcript levels.	Triiodothyronine	144-148	catenin beta 1	Homo sapiens	180-186
20811782-3	2010	In this study, we show that insulin and T(3) have an inducing effect on FAS enzymatic activity, which is synergetic when both hormones are present.	Triiodothyronine	40-44	fatty acid synthase	Homo sapiens	72-75
20713192-6	2010	The latter finding was unexpected and suggested that the lack of functional MCT8 was counterbalanced at the thyrotrope cell level by high serum T3 concentration and/or by increased intrapituitary type 2 deiodinase (D2) activity.	Triiodothyronine	144-146	solute carrier family 16 member 2	Homo sapiens	76-80
20861217-1	2010	Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine.	Triiodothyronine	126-128	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	6-25
20861217-1	2010	Human cytochrome P450 4F2 (CYP4F2) catalyzes the omega-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine.	Triiodothyronine	126-128	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	27-33
20811782-12	2010	Our results suggest that in hepatic cells, hexanoate needs to be activated into a CoA derivative in order to inhibit the insulin and T(3)-induced FAS expression.	Triiodothyronine	133-137	fatty acid synthase	Homo sapiens	146-149
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	57-59	deiodinase, iodothyronine, type 3	Xenopus tropicalis	154-158
20453157-5	2010	Type 2 iodothyronine deiodinase (Dio2), which produces T(3) from thyroxin, was up-regulated in the DCM mice hearts.	Triiodothyronine	55-59	deiodinase, iodothyronine, type II	Mus musculus	33-37
20679730-4	2010	Thyroid glands in Mct8-KO mice contained more non-thyroglobulin-associated T4 and triiodothyronine than did those in wild-type mice, independent of deiodination.	Triiodothyronine	82-98	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	18-22
20679730-7	2010	Similarly, the secretion of T4 induced by injection of thyrotropin was reduced in Mct8-KO in which endogenous TSH and T4 were suppressed by administration of triiodothyronine.	Triiodothyronine	158-174	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	82-86
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	39-55	thyroid hormone receptor, beta	Xenopus tropicalis	140-146
20566590-11	2010	These results were confirmed by a meta-analysis including 11 033 individuals, and support a role for intracellular T(3) concentration in skeletal muscle on DM2 pathogenesis.	Triiodothyronine	115-119	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	156-159
20667986-5	2010	Compared with control conditions, T(3) supplementation increased the number of ESC-derived cardiomyocytes and was accompanied by up-regulation of a panel of cardiac markers, including Nkx2.5, myosin light chain-2V, as well as alpha- and beta-myosin heavy chain.	Triiodothyronine	34-38	NK2 homeobox 5	Mus musculus	184-190
20667986-5	2010	Compared with control conditions, T(3) supplementation increased the number of ESC-derived cardiomyocytes and was accompanied by up-regulation of a panel of cardiac markers, including Nkx2.5, myosin light chain-2V, as well as alpha- and beta-myosin heavy chain.	Triiodothyronine	34-38	myosin, light polypeptide 2, regulatory, cardiac, slow	Mus musculus	192-213
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	39-55	deiodinase, iodothyronine, type 2	Xenopus tropicalis	148-152
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	57-59	estrogen receptor 1	Xenopus tropicalis	160-167
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	39-55	deiodinase, iodothyronine, type 3	Xenopus tropicalis	154-158
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	39-55	estrogen receptor 1	Xenopus tropicalis	160-167
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	57-59	estrogen receptor 2	Xenopus tropicalis	172-178
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	39-55	estrogen receptor 2	Xenopus tropicalis	172-178
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	57-59	thyroid hormone receptor, beta	Xenopus tropicalis	140-146
20626568-7	2010	Exposure of premetamorphic tadpoles to triiodothyronine (T3; 0, 0.5, 5 and 50 nm) for 48 h resulted in concentration-dependent increases in trbeta, dio2, dio3, eralpha and erbeta.	Triiodothyronine	57-59	deiodinase, iodothyronine, type 2	Xenopus tropicalis	148-152
20682650-2	2010	We investigated the ability of tocotrienol (T3), an unsaturated vitamin E present in palm oil, rice bran, barley, oats, and wheat germ, to sensitize tumor cells to TRAIL.	Triiodothyronine	44-46	TNF superfamily member 10	Homo sapiens	164-169
20709985-2	2010	The aim of this study was to identify new variations in the gene to determine their effects on growth and fat traits in chicken and to observe the effects of the THRSPalpha gene on chicken lipid profile and lipoprotein and glucose and triiodothyronine effects on the THRSPalpha expression in liver and fat cells.	Triiodothyronine	235-251	thyroid hormone responsive	Gallus gallus	267-277
20709985-8	2010	The mRNA expression analysis in vivo and in vitro culture studies suggested that the THRSPalpha gene is more responsive to glucose than triiodothyronine.	Triiodothyronine	136-152	thyroid hormone responsive	Gallus gallus	85-95
20573951-6	2010	tRA treatment significantly increased uptake of triiodothyronine and thyroxine (4.1- and 4.3-fold, respectively), which was abolished by a selective Mct8 inhibitor, bromosulfophthalein.	Triiodothyronine	48-64	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	149-153
20449841-1	2010	A simple, reliable and repeatable method, based on CE with amperometric detection has been developed for the simultaneous separation and determination of thyroxine (T(4)) and 3,3",5-triiodothyronine (T(3)).	Triiodothyronine	175-198	solute carrier family 25 member 5	Homo sapiens	200-204
20146079-6	2010	In addition, C/EBP was upregulated in hepatoma cells after T(3) treatment and ectopic expression of MAT1A inhibited cell migration and invasion in J7 hepatoma cells.	Triiodothyronine	59-63	CCAAT enhancer binding protein alpha	Homo sapiens	13-18
20421340-0	2010	Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats.	Triiodothyronine	63-79	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	8-45
20421340-3	2010	UGT2B2 is thought to glucuronidate triiodothyronine (T(3)).	Triiodothyronine	35-51	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-6
20421340-3	2010	UGT2B2 is thought to glucuronidate triiodothyronine (T(3)).	Triiodothyronine	53-57	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-6
21048841-4	2010	L-[(3)H]phenylalanine uptake into 3T3-L1 cells was saturable (K(m) of 31 muM), competitively inhibited by T(3) (K(i) of 1.2 muM) and blocked by leucine, BCH, and rT(3) as expected for substrate interactions of System L1.	Triiodothyronine	106-110	chimerin 2	Mus musculus	153-156
20146079-8	2010	Together, these findings suggest that the expression of the MAT1A gene is mediated by C/EBP and is indirectly upregulated by T(3).	Triiodothyronine	125-129	methionine adenosyltransferase 1A	Homo sapiens	60-65
20160073-4	2010	Mc4r is expressed by hypothalamic paraventricular Thyrotropin-releasing hormone (TRH) neurons and increases energy usage through activation of Trh and production of the thyroid hormone tri-iodothyronine (T(3)).	Triiodothyronine	185-202	melanocortin 4 receptor	Mus musculus	0-4
20392835-5	2010	Interestingly, a PLB reporter gene containing only the core promoter sequences -156 to +64 displayed robust T(3)-dependent silencing in HL-1 cells, thus suggesting that transcriptional repression is facilitated by TRalpha1 via the PLB core promoter, a regulatory region highly conserved in mammals.	Triiodothyronine	108-112	phospholamban	Mus musculus	17-20
20392835-5	2010	Interestingly, a PLB reporter gene containing only the core promoter sequences -156 to +64 displayed robust T(3)-dependent silencing in HL-1 cells, thus suggesting that transcriptional repression is facilitated by TRalpha1 via the PLB core promoter, a regulatory region highly conserved in mammals.	Triiodothyronine	108-112	thyroid hormone receptor alpha	Mus musculus	214-222
20392835-5	2010	Interestingly, a PLB reporter gene containing only the core promoter sequences -156 to +64 displayed robust T(3)-dependent silencing in HL-1 cells, thus suggesting that transcriptional repression is facilitated by TRalpha1 via the PLB core promoter, a regulatory region highly conserved in mammals.	Triiodothyronine	108-112	phospholamban	Mus musculus	231-234
20392835-7	2010	Furthermore, addition of T(3) triggered alterations in covalent histone modifications at the PLB promoter that are associated with gene silencing, namely a pronounced decrease in both histone H3 acetylation and histone H3 lysine 4 methylation.	Triiodothyronine	25-29	phospholamban	Mus musculus	93-96
20392835-8	2010	Taken together, our data reveal that T(3)-dependent repression of PLB in cardiac myocytes is directly facilitated by TRalpha1 and involves the hormone-dependent recruitment of histone-modifying enzymes associated with transcriptional silencing.	Triiodothyronine	37-41	phospholamban	Mus musculus	66-69
20392835-8	2010	Taken together, our data reveal that T(3)-dependent repression of PLB in cardiac myocytes is directly facilitated by TRalpha1 and involves the hormone-dependent recruitment of histone-modifying enzymes associated with transcriptional silencing.	Triiodothyronine	37-41	thyroid hormone receptor alpha	Mus musculus	117-125
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	18-35	fibroblast growth factor 21	Mus musculus	138-165
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	18-35	fibroblast growth factor 21	Mus musculus	167-172
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	37-39	fibroblast growth factor 21	Mus musculus	138-165
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	37-39	fibroblast growth factor 21	Mus musculus	167-172
20080985-5	2010	This increase was mediated by T(3)-induced expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are master regulators of adipogenesis at both the mRNA and protein levels.	Triiodothyronine	30-34	peroxisome proliferator activated receptor gamma	Mus musculus	61-109
20080985-5	2010	This increase was mediated by T(3)-induced expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are master regulators of adipogenesis at both the mRNA and protein levels.	Triiodothyronine	30-34	peroxisome proliferator activated receptor gamma	Mus musculus	111-120
20080985-5	2010	This increase was mediated by T(3)-induced expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are master regulators of adipogenesis at both the mRNA and protein levels.	Triiodothyronine	30-34	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	126-162
20080985-5	2010	This increase was mediated by T(3)-induced expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), which are master regulators of adipogenesis at both the mRNA and protein levels.	Triiodothyronine	30-34	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	164-174
20018842-3	2010	Exposure of DCs to triiodothyronine (T(3)) resulted in a rapid and sustained increase in Akt phosphorylation independently of phosphatidylinositol 3-kinase activation, which was essential for supporting T(3)-induced DC maturation and interleukin (IL)-12 production.	Triiodothyronine	19-35	AKT serine/threonine kinase 1	Homo sapiens	89-92
20018842-3	2010	Exposure of DCs to triiodothyronine (T(3)) resulted in a rapid and sustained increase in Akt phosphorylation independently of phosphatidylinositol 3-kinase activation, which was essential for supporting T(3)-induced DC maturation and interleukin (IL)-12 production.	Triiodothyronine	37-41	AKT serine/threonine kinase 1	Homo sapiens	89-92
20018842-3	2010	Exposure of DCs to triiodothyronine (T(3)) resulted in a rapid and sustained increase in Akt phosphorylation independently of phosphatidylinositol 3-kinase activation, which was essential for supporting T(3)-induced DC maturation and interleukin (IL)-12 production.	Triiodothyronine	203-207	AKT serine/threonine kinase 1	Homo sapiens	89-92
20018842-7	2010	Thus, a T(3)-induced NF-kappaB-dependent mechanism controls TR beta(1) expression, which in turn signals DCs to promote maturation and function via an Akt-dependent but PI3K-independent pathway.	Triiodothyronine	8-12	T cell receptor beta locus	Homo sapiens	60-67
20018842-7	2010	Thus, a T(3)-induced NF-kappaB-dependent mechanism controls TR beta(1) expression, which in turn signals DCs to promote maturation and function via an Akt-dependent but PI3K-independent pathway.	Triiodothyronine	8-12	AKT serine/threonine kinase 1	Homo sapiens	151-154
20088828-2	2010	It has been demonstrated previously that renal Npt2a protein and its mRNA expression are both up-regulated by the thyroid hormone T3 (3,3",5-tri-iodothyronine) in rats.	Triiodothyronine	130-132	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	47-52
20206658-0	2010	Effect of triiodothyronine on 5-HT1A and 5-HT1B receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test.	Triiodothyronine	10-26	5-hydroxytryptamine receptor 1A	Rattus norvegicus	30-47
20122986-6	2010	Angiotensin II further increased the apoptotic rate of T(3)-induced hypertrophied cardiomyocytes.	Triiodothyronine	55-59	angiotensinogen	Rattus norvegicus	0-14
20094971-0	2010	Effect of triiodothyronine on adiponectin expression and leptin release by white adipose tissue of normal rats.	Triiodothyronine	10-26	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	30-41
20094971-3	2010	In the present study, we investigated the effect of triiodothyronine (T3) on the expression of adiponectin mRNA and the release of leptin and adiponectin by white adipose tissue (WAT) explants obtained from epididymal (visceral) or inguinal (subcutaneous) depots from normal rats.	Triiodothyronine	52-68	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	95-106
20094971-3	2010	In the present study, we investigated the effect of triiodothyronine (T3) on the expression of adiponectin mRNA and the release of leptin and adiponectin by white adipose tissue (WAT) explants obtained from epididymal (visceral) or inguinal (subcutaneous) depots from normal rats.	Triiodothyronine	70-72	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	95-106
20094971-3	2010	In the present study, we investigated the effect of triiodothyronine (T3) on the expression of adiponectin mRNA and the release of leptin and adiponectin by white adipose tissue (WAT) explants obtained from epididymal (visceral) or inguinal (subcutaneous) depots from normal rats.	Triiodothyronine	70-72	leptin	Rattus norvegicus	131-137
20094971-3	2010	In the present study, we investigated the effect of triiodothyronine (T3) on the expression of adiponectin mRNA and the release of leptin and adiponectin by white adipose tissue (WAT) explants obtained from epididymal (visceral) or inguinal (subcutaneous) depots from normal rats.	Triiodothyronine	70-72	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	142-153
20088828-2	2010	It has been demonstrated previously that renal Npt2a protein and its mRNA expression are both up-regulated by the thyroid hormone T3 (3,3",5-tri-iodothyronine) in rats.	Triiodothyronine	134-158	solute carrier family 34 (sodium phosphate), member 1	Mus musculus	47-52
19846169-0	2010	Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss.	Triiodothyronine	40-56	leptin	Rattus norvegicus	67-73
20080850-16	2010	CONCLUSIONS: Acute administration of T(3) in the BSD cardiac donor reverses the low T(3) state and increases expression of the mRNAs encoding Kv1.5 and SERCA2a, but not ADRB1 or PLB and is not associated with any improvement in hemodynamic performance.	Triiodothyronine	37-41	potassium voltage-gated channel subfamily A member 5	Homo sapiens	142-147
20080850-16	2010	CONCLUSIONS: Acute administration of T(3) in the BSD cardiac donor reverses the low T(3) state and increases expression of the mRNAs encoding Kv1.5 and SERCA2a, but not ADRB1 or PLB and is not associated with any improvement in hemodynamic performance.	Triiodothyronine	37-41	phospholamban	Homo sapiens	178-181
19996182-6	2010	Our findings indicate that the enhanced uptake and accumulation of T(4) in the kidneys of MCT8 null mice together with the increased renal conversion of T(4) into T(3) by increased renal deiodinase type 1 activities contributes to the generation of the low-serum T(4) and the increase in circulating T(3) levels, a hallmark of MCT8 deficiency.	Triiodothyronine	163-167	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	90-94
19996182-6	2010	Our findings indicate that the enhanced uptake and accumulation of T(4) in the kidneys of MCT8 null mice together with the increased renal conversion of T(4) into T(3) by increased renal deiodinase type 1 activities contributes to the generation of the low-serum T(4) and the increase in circulating T(3) levels, a hallmark of MCT8 deficiency.	Triiodothyronine	300-304	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	90-94
19948729-3	2010	PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.	Triiodothyronine	55-59	pyruvate dehydrogenase kinase 4	Rattus norvegicus	0-4
19948729-7	2010	Following T(3) administration, there is an increase in the association of PGC-1 alpha with the rPDK4 promoter.	Triiodothyronine	10-14	PPARG coactivator 1 alpha	Rattus norvegicus	74-85
19948729-7	2010	Following T(3) administration, there is an increase in the association of PGC-1 alpha with the rPDK4 promoter.	Triiodothyronine	10-14	pyruvate dehydrogenase kinase 4	Rattus norvegicus	95-100
19948729-9	2010	Administration of T(3) to hypothyroid rats elevated the abundance of PGC-1 alpha mRNA and protein in the liver.	Triiodothyronine	18-22	PPARG coactivator 1 alpha	Rattus norvegicus	69-80
19940039-10	2010	The combined effects of T(3)-induced AMPK activation and insulin stimulation were associated with increased sarcolemmal GLUT4 localization and glycolytic flux in the hyperthyroid heart.	Triiodothyronine	24-28	solute carrier family 2 member 4	Rattus norvegicus	120-125
19941883-7	2010	Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC(-)CD28(-)CD95(+) CD8 T cells from nonagenarians.	Triiodothyronine	17-33	CD28 molecule	Homo sapiens	93-97
19941883-7	2010	Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC(-)CD28(-)CD95(+) CD8 T cells from nonagenarians.	Triiodothyronine	17-33	Fas cell surface death receptor	Homo sapiens	100-104
19941883-7	2010	Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC(-)CD28(-)CD95(+) CD8 T cells from nonagenarians.	Triiodothyronine	35-37	CD28 molecule	Homo sapiens	93-97
19941883-7	2010	Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC(-)CD28(-)CD95(+) CD8 T cells from nonagenarians.	Triiodothyronine	35-37	Fas cell surface death receptor	Homo sapiens	100-104
19137427-1	2010	3,5,3"-Triido-L: -thyronine (T3) exerts pleiotropic actions on development and homeostasis mostly via its nuclear receptors, TRalpha1, TRbeta1, and TRbeta2, encoded by the THRA and THRB genes.	Triiodothyronine	29-31	thyroid hormone receptor alpha	Mus musculus	125-133
19137427-1	2010	3,5,3"-Triido-L: -thyronine (T3) exerts pleiotropic actions on development and homeostasis mostly via its nuclear receptors, TRalpha1, TRbeta1, and TRbeta2, encoded by the THRA and THRB genes.	Triiodothyronine	29-31	thyroid hormone receptor alpha	Mus musculus	172-176
19137427-1	2010	3,5,3"-Triido-L: -thyronine (T3) exerts pleiotropic actions on development and homeostasis mostly via its nuclear receptors, TRalpha1, TRbeta1, and TRbeta2, encoded by the THRA and THRB genes.	Triiodothyronine	29-31	thyroid hormone receptor beta	Mus musculus	181-185
19853653-6	2010	By additional introduction of the general coactivator SRC-1 cDNA into the yeasts, a higher response to endogenous thyroid hormones, thyroxine (T4), and triiodothyronine (T3) was obtained.	Triiodothyronine	152-168	Src1p	Saccharomyces cerevisiae S288C	54-59
19853653-6	2010	By additional introduction of the general coactivator SRC-1 cDNA into the yeasts, a higher response to endogenous thyroid hormones, thyroxine (T4), and triiodothyronine (T3) was obtained.	Triiodothyronine	170-172	Src1p	Saccharomyces cerevisiae S288C	54-59
19682536-4	2010	In contrast to SLC10A2-7, cells co-expressing SLC10A1 and the deiodinase D1 demonstrate a dramatic increase in T3S and T4S metabolism.	Triiodothyronine	111-114	solute carrier family 10 member 1	Homo sapiens	46-53
19682536-5	2010	The SLC10A1 substrates taurocholate, DHEAS and E3S inhibit T3S and T4S transport.	Triiodothyronine	59-62	solute carrier family 10 member 1	Homo sapiens	4-11
19682536-5	2010	The SLC10A1 substrates taurocholate, DHEAS and E3S inhibit T3S and T4S transport.	Triiodothyronine	59-62	sulfotransferase family 2A member 1	Homo sapiens	37-42
19682536-6	2010	Furthermore, co-transfection of SLC10A1 with CRYM, a well-known intracellular iodothyronine-binding protein, results in an enhanced intracellular accumulation of T3S and T4S, indicating that CRYM binds iodothyronine sulfates.	Triiodothyronine	162-165	solute carrier family 10 member 1	Homo sapiens	32-39
19682536-6	2010	Furthermore, co-transfection of SLC10A1 with CRYM, a well-known intracellular iodothyronine-binding protein, results in an enhanced intracellular accumulation of T3S and T4S, indicating that CRYM binds iodothyronine sulfates.	Triiodothyronine	162-165	crystallin mu	Homo sapiens	45-49
19682536-6	2010	Furthermore, co-transfection of SLC10A1 with CRYM, a well-known intracellular iodothyronine-binding protein, results in an enhanced intracellular accumulation of T3S and T4S, indicating that CRYM binds iodothyronine sulfates.	Triiodothyronine	162-165	crystallin mu	Homo sapiens	191-195
20032059-5	2010	To investigate the regulation of MGF expression in heart, mice were treated with thyroid hormone (T(3)) for 12 d to induce physiological cardiac hypertrophy.	Triiodothyronine	98-102	kit ligand	Mus musculus	33-36
20032059-10	2010	Importantly, when cardiomyocytes were contractile arrested by KCl, simultaneous exposure to T(3) prevented the up-regulation of MGF, whereas IGF-IEa was still induced.	Triiodothyronine	92-96	KIT ligand	Rattus norvegicus	128-131
20032197-3	2010	In this report we show that T(3) negatively interferes with MAPK p38 and nuclear factor-kappaB (NF-kappaB) activation by TNFalpha in GH4C1 cells.	Triiodothyronine	28-32	mitogen activated protein kinase 14	Rattus norvegicus	65-68
20032197-3	2010	In this report we show that T(3) negatively interferes with MAPK p38 and nuclear factor-kappaB (NF-kappaB) activation by TNFalpha in GH4C1 cells.	Triiodothyronine	28-32	tumor necrosis factor	Rattus norvegicus	121-129
20032197-8	2010	Conversely, DUSP1 depletion abrogates the inhibitory effect of T(3) on the induction of NF-kappaB-dependent transcription by TNFalpha.	Triiodothyronine	63-67	dual specificity phosphatase 1	Rattus norvegicus	12-17
20032197-8	2010	Conversely, DUSP1 depletion abrogates the inhibitory effect of T(3) on the induction of NF-kappaB-dependent transcription by TNFalpha.	Triiodothyronine	63-67	tumor necrosis factor	Rattus norvegicus	125-133
20613948-5	2010	However, cardiomyocytes treated with T(3) presented an increase in TGF-beta1 expression, as well as an increase in protein synthesis.	Triiodothyronine	37-41	transforming growth factor beta 1	Homo sapiens	67-76
20613948-6	2010	The AT1R blockade prevented the T(3)-induced cardiomyocyte hypertrophy, while the AT2R blockage attenuated this response.	Triiodothyronine	32-36	angiotensin II receptor type 1	Homo sapiens	4-8
19846169-7	2010	The CRT group, submitted to dietary restriction with concomitant administration of a physiologic triiodothyronine dose, had thyroid hormone receptor beta expression at levels comparable with those observed in the control group and simultaneously increased leptin expression as compared with that in the CR group, suggesting that thyroid hormone modulates leptin expression under conditions of calorie restriction.	Triiodothyronine	97-113	thyroid hormone receptor beta	Rattus norvegicus	124-153
19846169-7	2010	The CRT group, submitted to dietary restriction with concomitant administration of a physiologic triiodothyronine dose, had thyroid hormone receptor beta expression at levels comparable with those observed in the control group and simultaneously increased leptin expression as compared with that in the CR group, suggesting that thyroid hormone modulates leptin expression under conditions of calorie restriction.	Triiodothyronine	97-113	leptin	Rattus norvegicus	256-262
19846169-7	2010	The CRT group, submitted to dietary restriction with concomitant administration of a physiologic triiodothyronine dose, had thyroid hormone receptor beta expression at levels comparable with those observed in the control group and simultaneously increased leptin expression as compared with that in the CR group, suggesting that thyroid hormone modulates leptin expression under conditions of calorie restriction.	Triiodothyronine	97-113	leptin	Rattus norvegicus	355-361
19602869-2	2010	TRH is expressed in other hypothalamic nuclei but is downregulated by 3,3",5-L-triiodothyronine (T(3)) exclusively in the PVN.	Triiodothyronine	97-101	thyrotropin releasing hormone	Rattus norvegicus	0-3
19602869-6	2010	RESULTS: In primary cultures of fetal hypothalamic cells, TRH mRNA levels rapidly diminished with 10 nM T(3) while they increased by 1 mM 8Br-cAMP (+/- T(3)).	Triiodothyronine	104-108	thyrotropin releasing hormone	Rattus norvegicus	58-61
20134187-5	2010	In vivo and in vitro experiments revealed that migration of developing thymocytes, including the export of mature T cells, is upregulated by hormones, such as growth hormone and triiodothyronine, through the modulation of ECM-mediated interactions, associated or not with the chemokine CXCL12.	Triiodothyronine	178-194	C-X-C motif chemokine ligand 12	Homo sapiens	286-292
19808902-5	2009	Development of a sustained-release T(3) preparation given as a single nighttime dose (together with levothyroxine once daily) might maintain physiological serum FT(4)-FT(3) ratio"s throughout 24 h. Genetic polymorphisms in deiodinase 2 and thyroid hormone transporters have been associated with well-being, fatigue, depression, and greater improvement on combination therapy.	Triiodothyronine	35-39	iodothyronine deiodinase 2	Homo sapiens	223-235
19946826-2	2009	To clarify the effect of T(3)-induced pulmonary hypertension on endothelial and inducible nitric oxide synthase (eNOS and iNOS) mRNA expression in the ventricles of the heart, semi quantitative reverse transcription-PCR was performed on total RNAs isolated from broiler chicken hearts after feeding supplementary T(3) (15 mg T3/kg) for 6 weeks.	Triiodothyronine	25-29	nitric oxide synthase 2	Gallus gallus	80-111
19648159-0	2009	Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent.	Triiodothyronine	26-43	solute carrier family 16 member 2	Homo sapiens	61-65
19946826-5	2009	The eNOS and iNOS genes were expressed in the right and left ventricles of control and T(3)-treated broilers at 12, 28 and 49 d of age.	Triiodothyronine	87-91	nitric oxide synthase 2	Gallus gallus	13-17
19946826-8	2009	The relative amount of iNOS mRNA expression in the right and left ventricles was lower in T(3)-treated broilers than in control broilers at 49 d of age, but not at 12 or 28 d. 4.	Triiodothyronine	90-94	nitric oxide synthase 2	Gallus gallus	23-27
19818291-6	2009	Serum T(3) showed negative correlation with serum NO and MDA whereas positive correlation with APOA1, GSH, and GSHPx in cirrhotic patients with HCV.	Triiodothyronine	6-10	apolipoprotein A1	Homo sapiens	95-100
19819978-6	2009	The acetylation TRalpha mutant lost the ability to transactivate even at high T(3) concentrations and acts as a dominant-negative inhibitor of wild-type TR activity.	Triiodothyronine	78-82	T cell receptor alpha locus	Homo sapiens	16-23
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	147-163	F-box protein 32	Rattus norvegicus	200-209
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	147-163	tripartite motif containing 63	Rattus norvegicus	214-219
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	147-163	cathepsin L	Rattus norvegicus	275-286
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	147-163	caspase 3	Rattus norvegicus	302-311
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	165-167	F-box protein 32	Rattus norvegicus	200-209
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	165-167	tripartite motif containing 63	Rattus norvegicus	214-219
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	165-167	cathepsin L	Rattus norvegicus	275-286
19777444-4	2009	We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown.	Triiodothyronine	165-167	caspase 3	Rattus norvegicus	302-311
21665837-5	2009	Dio2 locally converts prohormone thyroxine (T(4)) to bioactive triiodothyronine (T(3)) in the MBH, which subsequently stimulates the gonadal axis.	Triiodothyronine	63-79	deiodinase, iodothyronine, type II	Mus musculus	0-4
21665837-5	2009	Dio2 locally converts prohormone thyroxine (T(4)) to bioactive triiodothyronine (T(3)) in the MBH, which subsequently stimulates the gonadal axis.	Triiodothyronine	81-85	deiodinase, iodothyronine, type II	Mus musculus	0-4
19497976-4	2009	In contrast and as in serum, liver T(3) content is high, resulting in increased deiodinase 1 (D1), suggesting that in this tissue TH entry is Mct8 independent.	Triiodothyronine	35-39	deiodinase, iodothyronine, type I	Mus musculus	80-92
20030174-5	2009	Serum apoB-48 concentration was measured by chemiluminescence enzyme immunoassay (CLEIA) and it correlated with thyroid stimulating hormone (TSH), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides(TG), but negatively correlated with free thyroxine (FT4) and free triiodothyronine (FT3).	Triiodothyronine	299-315	apolipoprotein B	Homo sapiens	6-13
19534619-2	2009	Type 1 iodothyronine deiodinase (DIO1) catalyzes deiodination of thyroxine generating triiodothyronine, an important regulator of cell proliferation and differentiation.	Triiodothyronine	86-102	iodothyronine deiodinase 1	Homo sapiens	33-37
19788857-5	2009	The hepatic mRNA level of ANKRD9 was repressed by thyroid hormone (T(3)) and fasting, elevated by re-feeding upon fasting.	Triiodothyronine	67-71	ankyrin repeat domain 9	Gallus gallus	26-32
19497976-4	2009	In contrast and as in serum, liver T(3) content is high, resulting in increased deiodinase 1 (D1), suggesting that in this tissue TH entry is Mct8 independent.	Triiodothyronine	35-39	deiodinase, iodothyronine, type I	Mus musculus	94-96
19470373-1	2009	The promoter elements and transcription factors necessary for triiodothyronine (T3) induction of hepatic HMG-CoA reductase (HMGR) were investigated by transfecting rat livers with wild type and mutant HMGR promoter-luciferase constructs using in vivo electroporation.	Triiodothyronine	62-78	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	105-122
19460859-3	2009	The effect of conditioned medium from T(3)-treated glial cells was mimicked by basic fibroblast growth factor (bFGF), known to be released from cerebellar glial cells after T(3) treatment.	Triiodothyronine	38-42	fibroblast growth factor 2	Rattus norvegicus	79-109
19460859-3	2009	The effect of conditioned medium from T(3)-treated glial cells was mimicked by basic fibroblast growth factor (bFGF), known to be released from cerebellar glial cells after T(3) treatment.	Triiodothyronine	38-42	fibroblast growth factor 2	Rattus norvegicus	111-115
19460859-5	2009	This suggests that the up-regulation of the neuronal sodium current density by T(3) is not a direct effect but involves bFGF release and satellite cells.	Triiodothyronine	79-83	fibroblast growth factor 2	Rattus norvegicus	120-124
19435853-7	2009	Only the levels of free triiodothyronine showed a slight decrease in caveolin-1 knockout mice.	Triiodothyronine	24-40	caveolin 1, caveolae protein	Mus musculus	69-79
19470373-1	2009	The promoter elements and transcription factors necessary for triiodothyronine (T3) induction of hepatic HMG-CoA reductase (HMGR) were investigated by transfecting rat livers with wild type and mutant HMGR promoter-luciferase constructs using in vivo electroporation.	Triiodothyronine	62-78	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	124-128
19470373-1	2009	The promoter elements and transcription factors necessary for triiodothyronine (T3) induction of hepatic HMG-CoA reductase (HMGR) were investigated by transfecting rat livers with wild type and mutant HMGR promoter-luciferase constructs using in vivo electroporation.	Triiodothyronine	80-82	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	105-122
19470373-1	2009	The promoter elements and transcription factors necessary for triiodothyronine (T3) induction of hepatic HMG-CoA reductase (HMGR) were investigated by transfecting rat livers with wild type and mutant HMGR promoter-luciferase constructs using in vivo electroporation.	Triiodothyronine	80-82	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	124-128
19274054-12	2009	Retinoic acid and triiodothyronine increased UCP1 mRNA expression in the BAT(B) adipocytes 1.6- and 2-fold, respectively but, surprisingly, slightly decreased UCP1 mRNA expression in the WAT(B) adipocytes.	Triiodothyronine	18-34	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	45-49
19487700-5	2009	Intriguingly, the PAS-B domain in the p160 N terminus plays a previously unanticipated role in permitting TRbeta2 to recruit coactivator at limiting triiodothyronine concentrations.	Triiodothyronine	149-165	MYB binding protein 1a	Homo sapiens	38-42
19641107-9	2009	The majority of T(3) uptake in primary cortical neurons is mediated by Mct8, but pharmacological inhibition suggested functional expression of additional T(3) transporter classes.	Triiodothyronine	16-20	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	71-75
19336534-3	2009	Thyroid hormones (triiodothyronine (T(3)) and thyroxine (T(4))) increase SHBG accumulation in HepG2 cell culture medium over 5 days, and increase cellular SHBG mRNA levels.	Triiodothyronine	18-34	sex hormone binding globulin	Homo sapiens	73-77
19336534-3	2009	Thyroid hormones (triiodothyronine (T(3)) and thyroxine (T(4))) increase SHBG accumulation in HepG2 cell culture medium over 5 days, and increase cellular SHBG mRNA levels.	Triiodothyronine	18-34	sex hormone binding globulin	Homo sapiens	155-159
19336534-3	2009	Thyroid hormones (triiodothyronine (T(3)) and thyroxine (T(4))) increase SHBG accumulation in HepG2 cell culture medium over 5 days, and increase cellular SHBG mRNA levels.	Triiodothyronine	36-40	sex hormone binding globulin	Homo sapiens	73-77
19336534-3	2009	Thyroid hormones (triiodothyronine (T(3)) and thyroxine (T(4))) increase SHBG accumulation in HepG2 cell culture medium over 5 days, and increase cellular SHBG mRNA levels.	Triiodothyronine	36-40	sex hormone binding globulin	Homo sapiens	155-159
19274054-12	2009	Retinoic acid and triiodothyronine increased UCP1 mRNA expression in the BAT(B) adipocytes 1.6- and 2-fold, respectively but, surprisingly, slightly decreased UCP1 mRNA expression in the WAT(B) adipocytes.	Triiodothyronine	18-34	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	159-163
19158403-2	2009	Although both T(3) and T(4) stimulated extracellular signal-regulated kinase (ERK) 1/2, activated ERK1/2 did not contribute to T(3)-induced Src kinase or PI3-kinase activation, and an inhibitor of PI3-kinase, LY-294002, did not block activation of ERK1/2 by physiological concentrations of T(3) and T(4).	Triiodothyronine	14-18	mitogen-activated protein kinase 3	Homo sapiens	39-86
19147674-0	2009	Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3"-triiodo-L-thyronine.	Triiodothyronine	98-124	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	14-43
19158403-3	2009	Thus the PI3-kinase, Src kinase, and ERK1/2 signaling cascades are parallel pathways in T(3)-treated U-87 MG cells.	Triiodothyronine	88-92	mitogen-activated protein kinase 3	Homo sapiens	37-43
19158403-8	2009	A model proposes that one site binds T(3) exclusively, activates PI3-kinase via Src kinase, and stimulates TRalpha trafficking and HIF-1alpha gene expression.	Triiodothyronine	37-41	T cell receptor alpha locus	Homo sapiens	107-114
19158403-8	2009	A model proposes that one site binds T(3) exclusively, activates PI3-kinase via Src kinase, and stimulates TRalpha trafficking and HIF-1alpha gene expression.	Triiodothyronine	37-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
19276241-7	2009	Strikingly, myostatin (Gdf8), a potent negative regulator of muscle growth, was found to be strongly downregulated in EOMs from T(3)-treated animals.	Triiodothyronine	128-132	myostatin	Rattus norvegicus	23-27
19374345-1	2009	Protein disulfide isomerase (PDI) is a catalyst of isomerization of substrate protein intra- and extra-molecular disulfide bridges and also has 3,3",5-triiodo-l-thyronine (T(3))-binding activity and molecular chaperone-like activity.	Triiodothyronine	144-170	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
19374345-1	2009	Protein disulfide isomerase (PDI) is a catalyst of isomerization of substrate protein intra- and extra-molecular disulfide bridges and also has 3,3",5-triiodo-l-thyronine (T(3))-binding activity and molecular chaperone-like activity.	Triiodothyronine	144-170	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
19374345-1	2009	Protein disulfide isomerase (PDI) is a catalyst of isomerization of substrate protein intra- and extra-molecular disulfide bridges and also has 3,3",5-triiodo-l-thyronine (T(3))-binding activity and molecular chaperone-like activity.	Triiodothyronine	172-176	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
19374345-1	2009	Protein disulfide isomerase (PDI) is a catalyst of isomerization of substrate protein intra- and extra-molecular disulfide bridges and also has 3,3",5-triiodo-l-thyronine (T(3))-binding activity and molecular chaperone-like activity.	Triiodothyronine	172-176	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
19157766-0	2009	Somatotropin response in vitro to corticosterone and triiodothyronine during chick embryonic development: Involvement of type I and type II glucocorticoid receptors.	Triiodothyronine	53-69	growth hormone	Gallus gallus	0-12
19147674-7	2009	The results suggest that the main restriction for T(3) entry into the neural target cells of the mouse deficient in Mct8 is at the blood-brain barrier.	Triiodothyronine	50-54	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	116-120
19157766-3	2009	Secretion in response to CORT during embryonic development is modulated by the thyroid hormones triiodothyronine (T(3)) and thyroxine (T(4)).	Triiodothyronine	96-112	CORT	Gallus gallus	25-29
19211732-1	2009	Transcriptional regulation is mediated by thyroid hormone (tri-iodothyronine, T(3)) receptors (TR), which bind to T(3) response elements as heterodimers with retinoid X receptors (RXR).	Triiodothyronine	59-76	retinoid X receptor alpha	Homo sapiens	158-178
19190113-0	2009	Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.	Triiodothyronine	120-136	iodothyronine deiodinase 2	Homo sapiens	24-28
19211732-1	2009	Transcriptional regulation is mediated by thyroid hormone (tri-iodothyronine, T(3)) receptors (TR), which bind to T(3) response elements as heterodimers with retinoid X receptors (RXR).	Triiodothyronine	59-76	retinoid X receptor alpha	Homo sapiens	180-183
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	52-68	guanylate cyclase 2e	Mus musculus	44-48
19302190-5	2009	TRbeta(-/-) mice displayed higher basal levels of serum triiodothyronine (T(3)) and thyroxine (T(4)) compared to WT, reflecting thyroid hormone resistance.	Triiodothyronine	56-72	thyroid hormone receptor beta	Mus musculus	0-6
19158410-6	2009	Thyroid hormone levels were manipulated during development to show that T(3) inhibited BDNF, TRH, and BDNF receptor gene expression.	Triiodothyronine	72-76	brain derived neurotrophic factor	Gallus gallus	87-91
19158410-6	2009	Thyroid hormone levels were manipulated during development to show that T(3) inhibited BDNF, TRH, and BDNF receptor gene expression.	Triiodothyronine	72-76	thyrotropin releasing hormone	Gallus gallus	93-96
19158410-6	2009	Thyroid hormone levels were manipulated during development to show that T(3) inhibited BDNF, TRH, and BDNF receptor gene expression.	Triiodothyronine	72-76	brain derived neurotrophic factor	Gallus gallus	102-106
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	52-68	hemoglobin, beta adult major chain	Mus musculus	176-181
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	52-68	thyroid hormone receptor alpha	Mus musculus	187-195
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	70-72	guanylate cyclase 2e	Mus musculus	44-48
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	70-72	hemoglobin, beta adult major chain	Mus musculus	176-181
19280098-1	2009	Previous studies showed anabolic effects of GC-1, a triiodothyronine (T3) analogue that is selective for both binding and activation functions of thyroid hormone receptor (TR) beta1 over TRalpha1, on bone tissue in vivo.	Triiodothyronine	70-72	thyroid hormone receptor alpha	Mus musculus	187-195
20140304-2	2009	Considering that the underlying mechanisms are unknown, the aim of this study was to assess the involvement of inducible nitric oxide synthase (iNOS) expression and oxidative stress in T(3) preconditioning (PC).	Triiodothyronine	185-189	nitric oxide synthase 2	Rattus norvegicus	111-142
19022891-5	2009	HA-tagged WT MCT8 correctly localized to the plasma membrane in NT2 cells and increased T(3) uptake in both cell types.	Triiodothyronine	88-92	solute carrier family 16 member 2	Homo sapiens	13-17
19022891-10	2009	Finally, small interfering RNA depletion of endogenous MCT8 resulted in increased cell survival and decreased T(3) uptake.	Triiodothyronine	110-114	solute carrier family 16 member 2	Homo sapiens	55-59
19457782-6	2009	Simultaneous changes in hepatic type I deiodinase activity suggest that hepatic modulation of the leptin system by PG supplementation may be mediated by an increased local thyroxine-triiodothyronine conversion.	Triiodothyronine	182-198	leptin	Bos taurus	98-104
19018842-0	2009	Elevated serum triiodothyronine and intellectual and motor disability with paroxysmal dyskinesia caused by a monocarboxylate transporter 8 gene mutation.	Triiodothyronine	15-31	solute carrier family 16 member 2	Homo sapiens	109-138
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	0-29
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	31-35
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	39-46
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	106-108	solute carrier family 16 member 2	Homo sapiens	0-29
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	106-108	solute carrier family 16 member 2	Homo sapiens	31-35
19018842-1	2009	Monocarboxylate transporter 8 (MCT8 or SLC16A2) is important for the neuronal uptake of triiodothyronine (T3) in its function as a specific and active transporter of thyroid hormones across the cell membrane, thus being essential for human brain development.	Triiodothyronine	106-108	solute carrier family 16 member 2	Homo sapiens	39-46
19018842-6	2009	The identified MCT8 gene mutation (R271H) is very likely to be the genetic cause for neuronal hypothyroidism despite elevated serum T3 levels.	Triiodothyronine	132-134	solute carrier family 16 member 2	Homo sapiens	15-19
19076268-7	2009	By contrast, administration of triiodothyronine (T3) was often noted to have modest enhancing effects on CA1 cell firing rates in hippocampal slices from euthyroid animals.	Triiodothyronine	31-47	carbonic anhydrase 1	Rattus norvegicus	105-108
19076268-7	2009	By contrast, administration of triiodothyronine (T3) was often noted to have modest enhancing effects on CA1 cell firing rates in hippocampal slices from euthyroid animals.	Triiodothyronine	49-51	carbonic anhydrase 1	Rattus norvegicus	105-108
20140304-6	2009	It is concluded that T(3)-induced liver PC is associated with upregulation of iNOS expression as a protective mechanisms against IR injury, which is achieved through development of transient and reversible oxidative stress.	Triiodothyronine	21-25	nitric oxide synthase 2	Rattus norvegicus	78-82
18723843-8	2009	T(3)-induced expression of HIF1-alpha and vascular endothelial growth factor was further verified using a gastric cancer cell line and in vivo mouse model.	Triiodothyronine	0-4	hypoxia inducible factor 1, alpha subunit	Mus musculus	27-37
18636565-1	2009	Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3",5-triiodothyronine (T3).	Triiodothyronine	129-131	solute carrier family 16 member 2	Homo sapiens	0-29
18636565-1	2009	Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3",5-triiodothyronine (T3).	Triiodothyronine	129-131	solute carrier family 16 member 2	Homo sapiens	31-35
18636565-1	2009	Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3",5-triiodothyronine (T3).	Triiodothyronine	129-131	solute carrier family 16 member 2	Homo sapiens	53-60
18636565-2	2009	Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and low 3,3",5"-triiodothyronine (rT3) levels.	Triiodothyronine	81-83	solute carrier family 16 member 2	Homo sapiens	13-17
19261995-1	2009	Thyroglobulin is the precursor of the thyroid hormones, triiodothyronine and thyroxine.	Triiodothyronine	56-72	thyroglobulin	Bos taurus	0-13
18723843-10	2009	Furthermore we demonstrated that T(3)-induced overexpression of HIF1-alpha was mediated by fumarate accumulation and could be enhanced by fumarate hydratase inactivation but inhibited by 2-oxoglutarate.	Triiodothyronine	33-37	hypoxia inducible factor 1, alpha subunit	Mus musculus	64-74
18834645-5	2008	However, activation by TRalpha and derepression of TRbeta are T(3)-dependent and require intact SRE/DR-4 motifs.	Triiodothyronine	62-66	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	23-30
18380541-7	2009	Both in diabetes and after T(3) treatment the phosphorylation of Cx43 isoforms was markedly suppressed compared to the non-diabetic and T(3)-untreated controls.	Triiodothyronine	27-31	gap junction protein, alpha 1	Rattus norvegicus	65-69
18380541-7	2009	Both in diabetes and after T(3) treatment the phosphorylation of Cx43 isoforms was markedly suppressed compared to the non-diabetic and T(3)-untreated controls.	Triiodothyronine	136-140	gap junction protein, alpha 1	Rattus norvegicus	65-69
19246968-0	2008	Tamoxifen inhibits transforming growth factor-alpha gene expression in human breast carcinoma samples treated with triiodothyronine.	Triiodothyronine	115-131	tumor necrosis factor	Homo sapiens	19-51
19246968-1	2008	OBJECTIVES: To examine the effects of triiodothyronine (T3), 17beta-estradiol (E2), and tamoxifen (TAM) on transforming growth factor (TGF)-alpha gene expression in primary breast cancer cell cultures and interactions between the different treatments.	Triiodothyronine	56-58	transforming growth factor alpha	Homo sapiens	135-145
18641053-4	2008	The DIO3 is a 5-deiodinase that produces inactive iodothyronine metabolites, whereas DIO1 and DIO2 generate the active thyroid hormone, triiodothyronine, from the relatively inactive precursor, thyroxine.	Triiodothyronine	136-152	iodothyronine deiodinase 3	Bos taurus	4-8
18620020-1	2008	Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates.	Triiodothyronine	74-90	transthyretin	Homo sapiens	15-18
18620020-1	2008	Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates.	Triiodothyronine	92-94	transthyretin	Homo sapiens	15-18
19014670-0	2008	Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.	Triiodothyronine	18-34	hexokinase 2	Homo sapiens	111-114
19014670-0	2008	Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.	Triiodothyronine	18-34	E2F transcription factor 4	Homo sapiens	171-175
19014670-0	2008	Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.	Triiodothyronine	18-34	RB transcriptional corepressor like 1	Homo sapiens	186-190
19014670-0	2008	Thyroid hormone - triiodothyronine - has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) - role of E2F4, E2F5 and p107, p130.	Triiodothyronine	18-34	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	192-196
18708095-0	2008	Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity.	Triiodothyronine	0-16	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	71-91
18708095-0	2008	Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity.	Triiodothyronine	18-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	71-91
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	38-54	neuropeptide Y	Rattus norvegicus	180-194
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	38-54	neuropeptide Y	Rattus norvegicus	196-199
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	38-54	proopiomelanocortin	Rattus norvegicus	233-253
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	38-54	proopiomelanocortin	Rattus norvegicus	255-259
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	56-58	neuropeptide Y	Rattus norvegicus	180-194
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	56-58	neuropeptide Y	Rattus norvegicus	196-199
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	56-58	proopiomelanocortin	Rattus norvegicus	233-253
18708095-2	2008	We previously reported that rats with triiodothyronine (T3)-induced thyrotoxicosis display hyperphagia associated with suppressed circulating leptin levels, increased hypothalamic neuropeptide Y (NPY) mRNA and decreased hypothalamic pro-opiomelanocortin (POMC) mRNA.	Triiodothyronine	56-58	proopiomelanocortin	Rattus norvegicus	255-259
18708095-5	2008	Rats that were given s.c. injections of T3 (4.5 nmol/kg) had increased food intake 2 h later without alterations in NPY and POMC mRNA levels, but with increased hypothalamic phosphorylated AMPK (169%) and phosphorylated acetyl-CoA carboxylase (194%).	Triiodothyronine	40-42	neuropeptide Y	Rattus norvegicus	116-119
18708095-5	2008	Rats that were given s.c. injections of T3 (4.5 nmol/kg) had increased food intake 2 h later without alterations in NPY and POMC mRNA levels, but with increased hypothalamic phosphorylated AMPK (169%) and phosphorylated acetyl-CoA carboxylase (194%).	Triiodothyronine	40-42	proopiomelanocortin	Rattus norvegicus	124-128
18708095-5	2008	Rats that were given s.c. injections of T3 (4.5 nmol/kg) had increased food intake 2 h later without alterations in NPY and POMC mRNA levels, but with increased hypothalamic phosphorylated AMPK (169%) and phosphorylated acetyl-CoA carboxylase (194%).	Triiodothyronine	40-42	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	189-193
18778704-6	2008	Retinal Drd4 expression is not affected by removal of the sympathetic input to the eye, but triiodothyronine treatment induces Drd4 expression in the photoreceptors.	Triiodothyronine	92-108	dopamine receptor D4	Rattus norvegicus	127-131
19211990-6	2008	The present study suggests that liver CYP is regulated by the dopaminergic tuberoinfundibular pathway via growth hormone and triiodothyronine, while the mesolimbic pathway influences this enzyme via corticosterone and triiodothyronine.	Triiodothyronine	125-141	peptidylprolyl isomerase G	Homo sapiens	38-41
19211990-6	2008	The present study suggests that liver CYP is regulated by the dopaminergic tuberoinfundibular pathway via growth hormone and triiodothyronine, while the mesolimbic pathway influences this enzyme via corticosterone and triiodothyronine.	Triiodothyronine	218-234	peptidylprolyl isomerase G	Homo sapiens	38-41
18641053-4	2008	The DIO3 is a 5-deiodinase that produces inactive iodothyronine metabolites, whereas DIO1 and DIO2 generate the active thyroid hormone, triiodothyronine, from the relatively inactive precursor, thyroxine.	Triiodothyronine	136-152	type I iodothyronine deiodinase	Bos taurus	85-89
18641053-4	2008	The DIO3 is a 5-deiodinase that produces inactive iodothyronine metabolites, whereas DIO1 and DIO2 generate the active thyroid hormone, triiodothyronine, from the relatively inactive precursor, thyroxine.	Triiodothyronine	136-152	iodothyronine deiodinase 2	Bos taurus	94-98
18467449-2	2008	The gene encoding furin, as previously identified by cDNA microarray, is known to be up-regulated by T(3) treatment, and stimulated furin production occurs in thyroidectomized rats after administration of T(3).	Triiodothyronine	101-105	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	18-23
18803942-8	2008	Pearson correlation revealed that visfatin, glucose, insulin, and HOMA-IR values positively correlated with triiodothyronine and free thyroxine levels.	Triiodothyronine	108-124	nicotinamide phosphoribosyltransferase	Homo sapiens	34-42
18357515-8	2008	Thyroid hormone (T(3)) caused a significant inhibitory effect on ssTnI expression in myocardial cells whereas this effect was not evident in CHO cells.	Triiodothyronine	17-21	troponin I1, slow skeletal type	Homo sapiens	65-70
18552129-0	2008	Triiodothyronine utilizes phosphatidylinositol 3-kinase pathway to activate anti-apoptotic myeloid cell leukemia-1.	Triiodothyronine	0-16	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	91-114
18682832-11	2008	Remarkably, Fsp27(-/-) MEFs differentiated in vitro show many brown adipocyte characteristics in the presence of the thyroid hormone triiodothyronine (T3).	Triiodothyronine	133-149	cell death-inducing DFFA-like effector c	Mus musculus	12-17
18682832-11	2008	Remarkably, Fsp27(-/-) MEFs differentiated in vitro show many brown adipocyte characteristics in the presence of the thyroid hormone triiodothyronine (T3).	Triiodothyronine	151-153	cell death-inducing DFFA-like effector c	Mus musculus	12-17
18653622-1	2008	Transcriptional repression of the TSH-specific beta subunit (TSHbeta) gene has been regarded to be specific to thyroid hormone (tri-iodothyronine, T(3)) and its receptors (TRs) in physiological conditions.	Triiodothyronine	128-145	thyroid stimulating hormone subunit beta	Homo sapiens	61-68
18716886-7	2008	The concomitant injection of DHT and T3, with or without Dex, resulted in the reappearance of the full-fledged granular cells, only some of which were mK1-positive.	Triiodothyronine	37-39	keratin 1	Mus musculus	151-154
18219570-3	2008	In culture, T(3) induces cerebellar astrocytes to secrete growth factors, mainly FGF(2), and alters the expression and organization of the extracellular matrix (ECM) proteins, laminin, and fibronectin.	Triiodothyronine	12-16	fibronectin 1	Rattus norvegicus	189-200
18674911-6	2008	DIO2 initiates the summer response by increasing hypothalamic tri-iodothyronine (T3) levels.	Triiodothyronine	62-79	iodothyronine deiodinase 2	Homo sapiens	0-4
18674911-6	2008	DIO2 initiates the summer response by increasing hypothalamic tri-iodothyronine (T3) levels.	Triiodothyronine	81-83	iodothyronine deiodinase 2	Homo sapiens	0-4
18467449-2	2008	The gene encoding furin, as previously identified by cDNA microarray, is known to be up-regulated by T(3) treatment, and stimulated furin production occurs in thyroidectomized rats after administration of T(3).	Triiodothyronine	205-209	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	18-23
18467449-2	2008	The gene encoding furin, as previously identified by cDNA microarray, is known to be up-regulated by T(3) treatment, and stimulated furin production occurs in thyroidectomized rats after administration of T(3).	Triiodothyronine	205-209	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	132-137
18467449-5	2008	Furthermore, the invasiveness of HepG2-thyroid hormone receptor (TR) cells was significantly increased by T(3) treatment, perhaps due to furin processing of matrix metalloproteinase-2 and -9.	Triiodothyronine	106-110	furin (paired basic amino acid cleaving enzyme)	Mus musculus	137-142
18467449-5	2008	Furthermore, the invasiveness of HepG2-thyroid hormone receptor (TR) cells was significantly increased by T(3) treatment, perhaps due to furin processing of matrix metalloproteinase-2 and -9.	Triiodothyronine	106-110	matrix metallopeptidase 2	Mus musculus	157-190
18492748-0	2008	A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.	Triiodothyronine	106-122	iodothyronine deiodinase 1	Homo sapiens	40-44
18403482-11	2008	In addition, treatment of the cells with T(3) for 2 d induced the expression of thyroid hormone receptor-beta and caspase-3, and this thyroid hormone receptor-beta induction was drastically repressed by xTNF-alpha.	Triiodothyronine	41-45	caspase 3, gene 2 L homeolog	Xenopus laevis	114-163
18505435-8	2008	However, in GD absolute levels of anti-C1q correlated negatively with TSH and positively with free thyroxine (FT4) and triiodothyronine (FT3).	Triiodothyronine	119-135	complement C1q A chain	Homo sapiens	34-42
18403482-11	2008	In addition, treatment of the cells with T(3) for 2 d induced the expression of thyroid hormone receptor-beta and caspase-3, and this thyroid hormone receptor-beta induction was drastically repressed by xTNF-alpha.	Triiodothyronine	41-45	tumor necrosis factor L homeolog	Xenopus laevis	203-213
18403482-10	2008	T(3) induced apoptosis in these cells, but the addition of xTNF-alpha blocked the T(3)-induced apoptosis.	Triiodothyronine	82-86	tumor necrosis factor L homeolog	Xenopus laevis	59-69
18403482-13	2008	These findings suggested that xTNF-alpha could protect vascular endothelial cells from apoptotic cell death induced by T(3) during metamorphosis and thereby participate in the regulation of cell fate.	Triiodothyronine	119-123	tumor necrosis factor L homeolog	Xenopus laevis	30-40
19279731-1	2008	We have shown that there is significant disparity in the expression of uncoupling proteins (UCP) 2 and 3 between modern-commercial and ancient-Meishan porcine genotypes, commercial pigs also have higher plasma triiodothyronine (T(3)) in on the first day of life.	Triiodothyronine	210-226	mitochondrial uncoupling protein 2	Sus scrofa	71-104
18313043-5	2008	Stratified analysis showed that for women, serum T3 concentrations were negatively related to serum concentrations of PCB 138, PCB 153, the non-coplanar congeners, Arochlor 1260, and SigmaPCB, as well as p,p"-DDE.	Triiodothyronine	49-51	pyruvate carboxylase	Homo sapiens	118-121
18313043-5	2008	Stratified analysis showed that for women, serum T3 concentrations were negatively related to serum concentrations of PCB 138, PCB 153, the non-coplanar congeners, Arochlor 1260, and SigmaPCB, as well as p,p"-DDE.	Triiodothyronine	49-51	pyruvate carboxylase	Homo sapiens	127-130
19279731-1	2008	We have shown that there is significant disparity in the expression of uncoupling proteins (UCP) 2 and 3 between modern-commercial and ancient-Meishan porcine genotypes, commercial pigs also have higher plasma triiodothyronine (T(3)) in on the first day of life.	Triiodothyronine	228-233	mitochondrial uncoupling protein 2	Sus scrofa	71-104
19279731-7	2008	UCP3 mRNA abundance was higher in Meishan, than commercial piglets (p = 0.042) and was downregulated following T(3) administration (p = 0.014).	Triiodothyronine	111-115	uncoupling protein 3	Sus scrofa	0-4
18337592-7	2008	In the absence of CRYM, hMCT10 and hMCT8 increased T(3) uptake after 5 min incubation up to 4.0- and 1.9-fold, and in the presence of CRYM up to 6.9- and 5.8-fold, respectively.	Triiodothyronine	51-55	solute carrier family 16 member 10	Homo sapiens	24-30
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Triiodothyronine	120-136	thyroglobulin	Homo sapiens	12-25
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Triiodothyronine	120-136	thyroglobulin	Homo sapiens	27-29
18334584-2	2008	Lack of MCT8 transport of T(3) in neurons could explain the neurological phenotype.	Triiodothyronine	26-30	solute carrier family 16 member 2	Homo sapiens	8-12
18622045-9	2008	T(3)-induced down-regulation of Cx43 was associated with increased cardiac propensity to ventricular fibrillation.	Triiodothyronine	0-4	gap junction protein, alpha 1	Rattus norvegicus	32-36
18622045-11	2008	Suppression of epsilon-PKC and Cx43 phosphorylation by T(3) abolish benefit of adaptation rendering the heart prone to lethal arrhythmias.	Triiodothyronine	55-59	protein kinase C, gamma	Rattus norvegicus	23-26
18622045-11	2008	Suppression of epsilon-PKC and Cx43 phosphorylation by T(3) abolish benefit of adaptation rendering the heart prone to lethal arrhythmias.	Triiodothyronine	55-59	gap junction protein, alpha 1	Rattus norvegicus	31-35
18454446-7	2008	Triiodothyronine (T3) increased the level of beta(2)-AR and the effect of T3 was inhibited by bicalutamide.	Triiodothyronine	0-16	adrenoceptor beta 2	Homo sapiens	45-55
18334578-8	2008	The gene product of this DIO2 converts intracellular pro-hormone-3,3",5,5"-tetraiodothyronine (T4) into the active thyroid hormone 3,3",5-triiodothyronine (T3) thereby regulating intracellular levels of active T3 in target tissues such as the growth plate.	Triiodothyronine	156-158	iodothyronine deiodinase 2	Homo sapiens	25-29
18337592-7	2008	In the absence of CRYM, hMCT10 and hMCT8 increased T(3) uptake after 5 min incubation up to 4.0- and 1.9-fold, and in the presence of CRYM up to 6.9- and 5.8-fold, respectively.	Triiodothyronine	51-55	solute carrier family 16 member 2	Homo sapiens	35-40
18097751-0	2008	Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.	Triiodothyronine	18-37	AKT serine/threonine kinase 1	Homo sapiens	88-91
18097751-0	2008	Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.	Triiodothyronine	18-37	mechanistic target of rapamycin kinase	Homo sapiens	93-122
18097751-0	2008	Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.	Triiodothyronine	18-37	ribosomal protein S6 kinase B1	Homo sapiens	124-136
18097751-0	2008	Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.	Triiodothyronine	18-37	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	141-147
18097751-5	2008	In this study, we administrated 3,5,3"-triiodo-L: -thyronine (T3) into rat dorsal hippocampus and determined the phosphorylation of Akt and its downstream targets, mammalian target of rapamycin (mTOR), p70S6 kinase (p70S6k) and the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) signaling molecules.	Triiodothyronine	32-60	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
18097751-5	2008	In this study, we administrated 3,5,3"-triiodo-L: -thyronine (T3) into rat dorsal hippocampus and determined the phosphorylation of Akt and its downstream targets, mammalian target of rapamycin (mTOR), p70S6 kinase (p70S6k) and the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) signaling molecules.	Triiodothyronine	62-64	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
18484201-8	2008	Free triiodothyronine (FT3) negatively correlated with Apo B (r=.0.46, P=0.005) and Lp(a) (r=.0.31, P=0.03) in patients with SCH and negatively correlated with Lp(a) (r=.0.30, P=0.04) in controls.	Triiodothyronine	5-21	apolipoprotein B	Homo sapiens	55-60
18484201-8	2008	Free triiodothyronine (FT3) negatively correlated with Apo B (r=.0.46, P=0.005) and Lp(a) (r=.0.31, P=0.03) in patients with SCH and negatively correlated with Lp(a) (r=.0.30, P=0.04) in controls.	Triiodothyronine	5-21	lipoprotein(a)	Homo sapiens	84-89
18484201-8	2008	Free triiodothyronine (FT3) negatively correlated with Apo B (r=.0.46, P=0.005) and Lp(a) (r=.0.31, P=0.03) in patients with SCH and negatively correlated with Lp(a) (r=.0.30, P=0.04) in controls.	Triiodothyronine	5-21	lipoprotein(a)	Homo sapiens	160-165
18196550-1	2008	BACKGROUND: Studies suggest that triiodothyronine (T3) and cognate nuclear receptors (hTR) are involved in regulation of prostatic cell growth and differentiation.	Triiodothyronine	33-49	telomerase RNA component	Homo sapiens	86-89
18239067-4	2008	We and others have reported that T(3) stimulates HIF-1 activation, which intimately links T(3) and HIF-1 induced gene expression.	Triiodothyronine	33-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
18239067-4	2008	We and others have reported that T(3) stimulates HIF-1 activation, which intimately links T(3) and HIF-1 induced gene expression.	Triiodothyronine	33-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
18239067-4	2008	We and others have reported that T(3) stimulates HIF-1 activation, which intimately links T(3) and HIF-1 induced gene expression.	Triiodothyronine	90-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
18434374-6	2008	3,3",5-Triiodothyronine (T3) determined different biological responses (inhibition of cell adhesion, induction of migration, and increase in the expression of the neuronal marker neurofilament-M and Na+ and Ca2+ channel functionality) in both FNC and hMSC, which express TH receptors.	Triiodothyronine	0-23	musculin	Homo sapiens	251-255
18434374-6	2008	3,3",5-Triiodothyronine (T3) determined different biological responses (inhibition of cell adhesion, induction of migration, and increase in the expression of the neuronal marker neurofilament-M and Na+ and Ca2+ channel functionality) in both FNC and hMSC, which express TH receptors.	Triiodothyronine	25-27	musculin	Homo sapiens	251-255
18004648-2	2008	In this study, we examined the effect of 3,5,3"-L-triiodothyronine (T(3)) on the function and expression of Pgp using the human intestinal epithelial cell line Caco-2.	Triiodothyronine	68-72	ATP binding cassette subfamily B member 1	Homo sapiens	108-111
18004648-3	2008	MATERIALS AND METHODS: The effect of T(3) on the expression of Pgp and MDR1 mRNA was assessed by Western blotting and competitive polymerase chain reaction, respectively.	Triiodothyronine	37-41	ATP binding cassette subfamily B member 1	Homo sapiens	63-66
18004648-3	2008	MATERIALS AND METHODS: The effect of T(3) on the expression of Pgp and MDR1 mRNA was assessed by Western blotting and competitive polymerase chain reaction, respectively.	Triiodothyronine	37-41	ATP binding cassette subfamily B member 1	Homo sapiens	71-75
18187543-6	2008	Wild-type MCT8 increased T(3) uptake and metabolism about 5-fold compared with empty vector controls.	Triiodothyronine	25-29	solute carrier family 16 member 2	Homo sapiens	10-14
18004648-9	2008	CONCLUSIONS: These results indicate that T(3) regulates the expression and function of Pgp.	Triiodothyronine	41-45	ATP binding cassette subfamily B member 1	Homo sapiens	87-90
18196550-0	2008	Triiodothyronine modulates cell proliferation of human prostatic carcinoma cells by downregulation of the B-cell translocation gene 2.	Triiodothyronine	0-16	BTG anti-proliferation factor 2	Homo sapiens	106-133
18395756-5	2008	In the present study, L-triiodothyronine (L-T3) demonstrated differential regulation of phosphorylation status of five different synaptosomal proteins (63, 53, 38, 23, and 16 kD) in both a Ca(2+)/calmodulin (CaM)-dependent and -independent manner.	Triiodothyronine	22-40	calmodulin 1	Rattus norvegicus	196-206
18395756-5	2008	In the present study, L-triiodothyronine (L-T3) demonstrated differential regulation of phosphorylation status of five different synaptosomal proteins (63, 53, 38, 23, and 16 kD) in both a Ca(2+)/calmodulin (CaM)-dependent and -independent manner.	Triiodothyronine	22-40	calmodulin 1	Rattus norvegicus	208-211
18395756-5	2008	In the present study, L-triiodothyronine (L-T3) demonstrated differential regulation of phosphorylation status of five different synaptosomal proteins (63, 53, 38, 23, and 16 kD) in both a Ca(2+)/calmodulin (CaM)-dependent and -independent manner.	Triiodothyronine	42-46	calmodulin 1	Rattus norvegicus	196-206
18395756-5	2008	In the present study, L-triiodothyronine (L-T3) demonstrated differential regulation of phosphorylation status of five different synaptosomal proteins (63, 53, 38, 23, and 16 kD) in both a Ca(2+)/calmodulin (CaM)-dependent and -independent manner.	Triiodothyronine	42-46	calmodulin 1	Rattus norvegicus	208-211
18395756-7	2008	Ca(2+)/CaM further stimulated phosphorylation of 63- and 53-kD proteins by L-T3, which were inhibited both by EGTA (Ca(2+)-chelator) or KN62 (Ca(2+)/CaM kinase-II [CaMK-II] inhibitor), suggesting the role of CaMK-II.	Triiodothyronine	75-79	calmodulin 1	Rattus norvegicus	7-10
18395756-7	2008	Ca(2+)/CaM further stimulated phosphorylation of 63- and 53-kD proteins by L-T3, which were inhibited both by EGTA (Ca(2+)-chelator) or KN62 (Ca(2+)/CaM kinase-II [CaMK-II] inhibitor), suggesting the role of CaMK-II.	Triiodothyronine	75-79	calmodulin 1	Rattus norvegicus	149-152
18395756-10	2008	Surprisingly, l-T3-induced phosphorylation of 16-kD protein was not augmented further with Ca(2+) or Ca(2+)/CaM; instead, the presence of CaM abolished the L-T3-induced phosphorylation.	Triiodothyronine	14-18	calmodulin 1	Rattus norvegicus	138-141
18395756-10	2008	Surprisingly, l-T3-induced phosphorylation of 16-kD protein was not augmented further with Ca(2+) or Ca(2+)/CaM; instead, the presence of CaM abolished the L-T3-induced phosphorylation.	Triiodothyronine	156-160	calmodulin 1	Rattus norvegicus	138-141
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	36-52	CD80 antigen	Mus musculus	147-151
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	36-52	CD86 antigen	Mus musculus	153-157
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	36-52	CD40 antigen	Mus musculus	163-167
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	36-52	interferon gamma	Mus musculus	297-306
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	54-56	CD80 antigen	Mus musculus	147-151
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	54-56	CD86 antigen	Mus musculus	153-157
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	54-56	CD40 antigen	Mus musculus	163-167
17991732-5	2008	Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-gamma production in allogeneic T cell cultures.	Triiodothyronine	54-56	interferon gamma	Mus musculus	297-306
18399766-8	2008	Basal thyroxine-binding globulin (TBG) and cholesterol levels decreased, and ferritin and SHBG increased after L-T(3) administration, while creatine kinase and retinol did not change throughout the study.	Triiodothyronine	111-117	sex hormone binding globulin	Homo sapiens	90-94
18211968-0	2008	Growth hormone treatment of adults with Prader-Willi syndrome and growth hormone deficiency improves lean body mass, fractional body fat, and serum triiodothyronine without glucose impairment: results from the United States multicenter trial.	Triiodothyronine	148-164	growth hormone 1	Homo sapiens	0-14
18279020-2	2008	Triiodothyronine (T3) is the biologically active form of thyroid hormone that acts through nuclear receptors, TRalpha and TRbeta, regulating gene expression.	Triiodothyronine	0-16	T cell receptor alpha locus	Homo sapiens	110-117
18310446-1	2008	The aim of the present study was to examine whether triiodo-l-thyronine (T(3)) or l-thyroxine (T(4)) rapidly activated the mitogen-activated protein kinase (MAPK) intracellular signalling cascade in osteoblast-like cells and investigate whether this activation was initiated at the integrin alpha(V)beta(3) cell surface receptor.	Triiodothyronine	52-71	mitogen-activated protein kinase 1	Homo sapiens	157-161
18310446-1	2008	The aim of the present study was to examine whether triiodo-l-thyronine (T(3)) or l-thyroxine (T(4)) rapidly activated the mitogen-activated protein kinase (MAPK) intracellular signalling cascade in osteoblast-like cells and investigate whether this activation was initiated at the integrin alpha(V)beta(3) cell surface receptor.	Triiodothyronine	52-71	integrin subunit alpha V	Homo sapiens	282-305
18283245-3	2008	In this study, we investigated serum serum insulin levels and their correlations with thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in hypothyroid women.	Triiodothyronine	151-167	insulin	Homo sapiens	43-50
18310446-6	2008	Both pretreatments significantly inhibited T(3)- and T(4)-stimulated ERK activation and abolished T(3)-stimulated thymidine incorporation (P<0.01).	Triiodothyronine	43-47	mitogen-activated protein kinase 1	Homo sapiens	69-72
18225975-5	2008	Direct and indirect effects of decreased serum leptin, as well as effects of increased local triiodothyronine (T3) concentrations, in the hypothalamus during food deprivation contribute to the decreased activity of TRH neurons in the PVN.	Triiodothyronine	93-109	thyrotropin releasing hormone	Homo sapiens	215-218
18225975-5	2008	Direct and indirect effects of decreased serum leptin, as well as effects of increased local triiodothyronine (T3) concentrations, in the hypothalamus during food deprivation contribute to the decreased activity of TRH neurons in the PVN.	Triiodothyronine	111-113	thyrotropin releasing hormone	Homo sapiens	215-218
18279020-2	2008	Triiodothyronine (T3) is the biologically active form of thyroid hormone that acts through nuclear receptors, TRalpha and TRbeta, regulating gene expression.	Triiodothyronine	0-16	T cell receptor beta locus	Homo sapiens	122-128
18279020-2	2008	Triiodothyronine (T3) is the biologically active form of thyroid hormone that acts through nuclear receptors, TRalpha and TRbeta, regulating gene expression.	Triiodothyronine	18-20	T cell receptor alpha locus	Homo sapiens	110-117
18279020-2	2008	Triiodothyronine (T3) is the biologically active form of thyroid hormone that acts through nuclear receptors, TRalpha and TRbeta, regulating gene expression.	Triiodothyronine	18-20	T cell receptor beta locus	Homo sapiens	122-128
18042466-1	2008	We have previously reported that a redox-silent analogue of alpha-tocotrienol (T3), 6-O-carboxypropyl-alpha-tocotrienol (T3E) shows more potential anti-carcinogenic property than T3 in a lung cancer cell (A549 cell).	Triiodothyronine	79-81	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	121-124
17962579-0	2008	Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo.	Triiodothyronine	17-19	mitogen activated protein kinase 14	Rattus norvegicus	39-42
18418673-10	2008	Mutations in MCT8 are associated with severe X-linked psycomotor retardation and strongly elevated serum T3 levels in young male patients.	Triiodothyronine	105-107	solute carrier family 16 member 2	Homo sapiens	13-17
18020968-7	2008	Both milk and serum resistin concentrations were correlated positively with maternal serum estradiol, progesterone, prolactin, thyroxine, triiodothyronine, cortisol, leptin and C-reactive protein concentrations.	Triiodothyronine	138-154	resistin	Homo sapiens	20-28
17962579-0	2008	Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo.	Triiodothyronine	17-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	47-51
17962579-11	2008	Possible downstream consequences of T(3)-induced kinase phosphorylation were investigated by measuring cAMP response element binding protein (CREB) and thyroid hormone receptor DNA binding, as well as peroxisome proliferator-activated receptor-alpha coactivator-1 mRNA levels.	Triiodothyronine	36-40	cAMP responsive element binding protein 1	Rattus norvegicus	103-140
17962579-11	2008	Possible downstream consequences of T(3)-induced kinase phosphorylation were investigated by measuring cAMP response element binding protein (CREB) and thyroid hormone receptor DNA binding, as well as peroxisome proliferator-activated receptor-alpha coactivator-1 mRNA levels.	Triiodothyronine	36-40	cAMP responsive element binding protein 1	Rattus norvegicus	142-146
17962579-16	2008	Moreover, the T(3)-induced phosphorylation of p38 and AMPK in both slow- and fast-twitch skeletal muscles suggests that these events may be important in mediating hormone-induced increases in mitochondrial biogenesis in skeletal muscle.	Triiodothyronine	14-18	mitogen activated protein kinase 14	Rattus norvegicus	46-49
17962579-16	2008	Moreover, the T(3)-induced phosphorylation of p38 and AMPK in both slow- and fast-twitch skeletal muscles suggests that these events may be important in mediating hormone-induced increases in mitochondrial biogenesis in skeletal muscle.	Triiodothyronine	14-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	54-58
17992637-1	2007	Leptin has been shown to modulate deiodinase type 1 (D1) and type 2 (D2) enzymes responsible for thyroxine (T4) to triiodothyronine (T3) conversion.	Triiodothyronine	115-131	leptin	Rattus norvegicus	0-6
18166539-1	2008	Monocarboxylate transporter 8 acts as a specific cell membrane transporter for thyroxine and especially triiodothyronine into target cells.	Triiodothyronine	104-120	solute carrier family 16 member 2	Homo sapiens	0-29
18076426-6	2007	The reduction in serum testosterone level could be explained by (i) a reduced uptake of LDL-C by the Leydig cells and thereby a reduction in the synthesis of progesterone and consequentially testosterone, (ii) a further reduction in the rate of conversion of progesterone to testosterone, (iii) a higher rate of conversion of testosterone to oestradiol, (iv) a decrease in serum triiodothyronine and (v) hyperprolactinaemia.	Triiodothyronine	379-395	component of oligomeric golgi complex 2	Homo sapiens	88-93
18031379-12	2007	This beneficial effect may in part be due to prevention of T(3)-induced stimulation of collagen synthesis and reduction of MMP-2 secretion.	Triiodothyronine	59-63	matrix metallopeptidase 2	Rattus norvegicus	123-128
17928132-1	2007	We previously isolated a bisphenol A (BPA)-binding protein from rat brain and showed that it was identical to the protein disulfide isomerase (PDI), which also serves as a 3,3",5-triiodo-l-thyronine (T3)-binding protein.	Triiodothyronine	172-198	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	114-141
17928132-1	2007	We previously isolated a bisphenol A (BPA)-binding protein from rat brain and showed that it was identical to the protein disulfide isomerase (PDI), which also serves as a 3,3",5-triiodo-l-thyronine (T3)-binding protein.	Triiodothyronine	172-198	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	143-146
17928132-1	2007	We previously isolated a bisphenol A (BPA)-binding protein from rat brain and showed that it was identical to the protein disulfide isomerase (PDI), which also serves as a 3,3",5-triiodo-l-thyronine (T3)-binding protein.	Triiodothyronine	200-202	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	114-141
17928132-1	2007	We previously isolated a bisphenol A (BPA)-binding protein from rat brain and showed that it was identical to the protein disulfide isomerase (PDI), which also serves as a 3,3",5-triiodo-l-thyronine (T3)-binding protein.	Triiodothyronine	200-202	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	143-146
18079609-3	2007	Moreover, the UCP induction was accelerated by triiodothyronine (T3) or epinephrine, and reached a maximum at 2 h. It appeared that the induction of UCP mRNA and protein was rapid.	Triiodothyronine	47-63	uncoupling protein 1	Rattus norvegicus	14-17
17951546-7	2007	Lep group had hyperleptinemia (+22%) and lower free tri-iodothyronine (FT(3); -33%).	Triiodothyronine	52-69	leptin	Rattus norvegicus	0-3
17910524-1	2007	We show here that the promoter of E2F1 gene, encoding one of the key regulators of cell proliferation, is overly active in the presence of low amounts of triiodothyronine (T3) and in the presence of mutant thyroid hormone receptor.	Triiodothyronine	154-170	E2F transcription factor 1 L homeolog	Xenopus laevis	34-38
17910524-1	2007	We show here that the promoter of E2F1 gene, encoding one of the key regulators of cell proliferation, is overly active in the presence of low amounts of triiodothyronine (T3) and in the presence of mutant thyroid hormone receptor.	Triiodothyronine	172-174	E2F transcription factor 1 L homeolog	Xenopus laevis	34-38
18026700-0	2007	Histidine decarboxylase (HDC) knock out mouse immune cells have altered expression of ACTH, triiodothyronine and endorphin.	Triiodothyronine	92-108	histidine decarboxylase	Mus musculus	0-23
18026700-0	2007	Histidine decarboxylase (HDC) knock out mouse immune cells have altered expression of ACTH, triiodothyronine and endorphin.	Triiodothyronine	92-108	histidine decarboxylase	Mus musculus	25-28
18079609-3	2007	Moreover, the UCP induction was accelerated by triiodothyronine (T3) or epinephrine, and reached a maximum at 2 h. It appeared that the induction of UCP mRNA and protein was rapid.	Triiodothyronine	47-63	uncoupling protein 1	Rattus norvegicus	149-152
18079609-3	2007	Moreover, the UCP induction was accelerated by triiodothyronine (T3) or epinephrine, and reached a maximum at 2 h. It appeared that the induction of UCP mRNA and protein was rapid.	Triiodothyronine	65-67	uncoupling protein 1	Rattus norvegicus	14-17
18079609-3	2007	Moreover, the UCP induction was accelerated by triiodothyronine (T3) or epinephrine, and reached a maximum at 2 h. It appeared that the induction of UCP mRNA and protein was rapid.	Triiodothyronine	65-67	uncoupling protein 1	Rattus norvegicus	149-152
17426926-0	2007	Alterations in expression of senescence marker protein-30 gene by 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	66-92	regucalcin	Rattus norvegicus	29-57
17426926-0	2007	Alterations in expression of senescence marker protein-30 gene by 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	94-96	regucalcin	Rattus norvegicus	29-57
17426926-5	2007	The results indicate that there is an induction of SMP30 expression during early hours of T(3 )treatment and it declines in severe hyperthyroidism.	Triiodothyronine	90-95	regucalcin	Rattus norvegicus	51-56
17577579-0	2007	De-phosphorylation of TRalpha-1 by p44/42 MAPK inhibition enhances T(3)-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells.	Triiodothyronine	67-71	interferon induced protein 44	Homo sapiens	35-38
17577579-0	2007	De-phosphorylation of TRalpha-1 by p44/42 MAPK inhibition enhances T(3)-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells.	Triiodothyronine	67-71	solute carrier family 2 member 5	Homo sapiens	81-86
17577579-2	2007	We demonstrated not only that treatment with p44/42 MAPK inhibitor U0126 in intestinal cell line Caco-2 cells reduced the phosphorylation of serine and threonine residues of TRalpha-1, but also that T(3) and U0126 synergistically induced GLUT5 gene expression.	Triiodothyronine	199-203	interferon induced protein 44	Homo sapiens	45-48
17577579-3	2007	EMSA demonstrated that the binding activity of TRalpha-1-RXR heterodimer on GLUT5-TRE in nuclear proteins of Caco-2 cells was synergistically enhanced by co-incubation in vitro with T(3) and CIAP, which strongly de-phosphorylates proteins.	Triiodothyronine	182-186	solute carrier family 2 member 5	Homo sapiens	76-81
17478558-6	2007	This T(3)-induced early UCP3 expression depended on fatty acid-PPAR signaling because depleting serum fatty acid levels abolished its expression, restorable by administration of the PPARdelta agonist L165,041 (4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid).	Triiodothyronine	5-9	uncoupling protein 3	Rattus norvegicus	24-28
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	148-173	cyclin dependent kinase 2	Homo sapiens	17-42
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	148-173	cyclin dependent kinase 2	Homo sapiens	44-49
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	148-173	cyclin dependent kinase 2	Homo sapiens	250-255
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	175-179	cyclin dependent kinase 2	Homo sapiens	17-42
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	175-179	cyclin dependent kinase 2	Homo sapiens	44-49
17655502-2	2007	Considering that cyclin-dependent kinase-2 (CDK-2) performs essential functions for cellular proliferation, our aim was to test the hypothesis that l-3,3",5-triiodothyronine (T(3)) stimulates liver cell proliferation by upstream mechanisms involving CDK-2 expression dependent on Kupffer cell signaling.	Triiodothyronine	175-179	cyclin dependent kinase 2	Homo sapiens	250-255
17655502-3	2007	T(3) administration induced a calorigenic response at 60-70 h after treatment, with increased TNF-alpha generation and hepatic oxidative stress status, as shown by enhanced protein carbonyls and decreased glutathione content compared to controls.	Triiodothyronine	0-4	tumor necrosis factor	Homo sapiens	94-103
17655502-6	2007	We conclude that T(3) administration triggers liver CDK-2 expression and cellular proliferation through a cascade associated with Kupffer cell-dependent TNF-alpha generation, JNK phosphorylation, and AP-1 activation.	Triiodothyronine	17-21	cyclin dependent kinase 2	Homo sapiens	52-57
17655502-6	2007	We conclude that T(3) administration triggers liver CDK-2 expression and cellular proliferation through a cascade associated with Kupffer cell-dependent TNF-alpha generation, JNK phosphorylation, and AP-1 activation.	Triiodothyronine	17-21	tumor necrosis factor	Homo sapiens	153-162
17655502-6	2007	We conclude that T(3) administration triggers liver CDK-2 expression and cellular proliferation through a cascade associated with Kupffer cell-dependent TNF-alpha generation, JNK phosphorylation, and AP-1 activation.	Triiodothyronine	17-21	mitogen-activated protein kinase 8	Homo sapiens	175-178
17655502-6	2007	We conclude that T(3) administration triggers liver CDK-2 expression and cellular proliferation through a cascade associated with Kupffer cell-dependent TNF-alpha generation, JNK phosphorylation, and AP-1 activation.	Triiodothyronine	17-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	200-204
17655502-7	2007	Since CDK-2 promotes phase S progression within the cell cycle, this response may constitute a major mechanism involved in T(3)-induced liver preconditioning to ischemia/reperfusion injury.	Triiodothyronine	123-127	cyclin dependent kinase 2	Homo sapiens	6-11
17478558-0	2007	Differential 3,5,3"-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids.	Triiodothyronine	13-36	uncoupling protein 3	Rattus norvegicus	60-80
17478558-5	2007	Within 8 h of single-dose T(3) administration, hypothyroid rats showed a rise in serum fatty acid levels concomitant with a rapid increase in UCP3 expression in gastrocnemius muscle, followed by inductions of peroxisome proliferator activated receptor delta (PPARdelta) (within 24 h) and PPAR target gene expression (after 24 h).	Triiodothyronine	26-30	uncoupling protein 3	Rattus norvegicus	142-146
17478558-5	2007	Within 8 h of single-dose T(3) administration, hypothyroid rats showed a rise in serum fatty acid levels concomitant with a rapid increase in UCP3 expression in gastrocnemius muscle, followed by inductions of peroxisome proliferator activated receptor delta (PPARdelta) (within 24 h) and PPAR target gene expression (after 24 h).	Triiodothyronine	26-30	peroxisome proliferator-activated receptor delta	Rattus norvegicus	209-257
17478558-6	2007	This T(3)-induced early UCP3 expression depended on fatty acid-PPAR signaling because depleting serum fatty acid levels abolished its expression, restorable by administration of the PPARdelta agonist L165,041 (4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid).	Triiodothyronine	5-9	peroxisome proliferator activated receptor alpha	Rattus norvegicus	63-67
17478558-5	2007	Within 8 h of single-dose T(3) administration, hypothyroid rats showed a rise in serum fatty acid levels concomitant with a rapid increase in UCP3 expression in gastrocnemius muscle, followed by inductions of peroxisome proliferator activated receptor delta (PPARdelta) (within 24 h) and PPAR target gene expression (after 24 h).	Triiodothyronine	26-30	peroxisome proliferator-activated receptor delta	Rattus norvegicus	259-268
17478558-5	2007	Within 8 h of single-dose T(3) administration, hypothyroid rats showed a rise in serum fatty acid levels concomitant with a rapid increase in UCP3 expression in gastrocnemius muscle, followed by inductions of peroxisome proliferator activated receptor delta (PPARdelta) (within 24 h) and PPAR target gene expression (after 24 h).	Triiodothyronine	26-30	peroxisome proliferator activated receptor alpha	Rattus norvegicus	259-263
17478558-6	2007	This T(3)-induced early UCP3 expression depended on fatty acid-PPAR signaling because depleting serum fatty acid levels abolished its expression, restorable by administration of the PPARdelta agonist L165,041 (4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid).	Triiodothyronine	5-9	peroxisome proliferator-activated receptor delta	Rattus norvegicus	182-191
17389703-0	2007	Sources of circulating 3,5,3"-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.	Triiodothyronine	23-46	iodothyronine deiodinase 2	Homo sapiens	94-137
17587391-7	2007	In pre-adipocytes, visfatin expression decreased by 23% at a concentration of 1 microM insulin, 15% at 1-15 nM T3, 15% at 10 nM-1 microM progesterone, 33-44% at 10 nM-1 microM testosterone, 50% with palmitate and 30% with oleate (p < 0.05 for all).	Triiodothyronine	111-113	nicotinamide phosphoribosyltransferase	Homo sapiens	19-27
17356046-0	2007	Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine.	Triiodothyronine	143-159	solute carrier family 16 member 2	Homo sapiens	23-52
17356046-2	2007	Recent evidence indicates that monocarboxylate transporter 8 (MCT8) is important for neuronal T(3) uptake.	Triiodothyronine	94-98	solute carrier family 16 member 2	Homo sapiens	31-60
17356046-2	2007	Recent evidence indicates that monocarboxylate transporter 8 (MCT8) is important for neuronal T(3) uptake.	Triiodothyronine	94-98	solute carrier family 16 member 2	Homo sapiens	62-66
17493933-5	2007	We further found that the addition of triiodothyronine (T3) prevented the BI-induced hypertrophic differentiation of redifferentiated chondrocytes via the suppression of Akt signaling.	Triiodothyronine	38-54	AKT serine/threonine kinase 1	Homo sapiens	170-173
17493933-5	2007	We further found that the addition of triiodothyronine (T3) prevented the BI-induced hypertrophic differentiation of redifferentiated chondrocytes via the suppression of Akt signaling.	Triiodothyronine	56-58	AKT serine/threonine kinase 1	Homo sapiens	170-173
17626455-8	2007	NP-L-exposed fish had 20% lower plasma insulin-like growth factor I (IGF-I) levels and 35% lower plasma triiodothyronine (T3).	Triiodothyronine	104-120	N-acetylneuraminate lyase	Salmo salar	0-4
17626455-8	2007	NP-L-exposed fish had 20% lower plasma insulin-like growth factor I (IGF-I) levels and 35% lower plasma triiodothyronine (T3).	Triiodothyronine	122-124	N-acetylneuraminate lyase	Salmo salar	0-4
17574005-5	2007	MCT8 mutations in humans are associated with severe psychomotor retardation and elevated 3,3",5-triiodothyronine (T(3)) levels.	Triiodothyronine	89-112	solute carrier family 16 member 2	Homo sapiens	0-4
17574005-5	2007	MCT8 mutations in humans are associated with severe psychomotor retardation and elevated 3,3",5-triiodothyronine (T(3)) levels.	Triiodothyronine	114-118	solute carrier family 16 member 2	Homo sapiens	0-4
17189629-6	2007	However, when results were additionally adjusted for p,p(")-DDE, inverse associations with T(3) were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p(")-DDE and T(3) also remained.	Triiodothyronine	91-95	pyruvate carboxylase	Homo sapiens	117-120
17189629-6	2007	However, when results were additionally adjusted for p,p(")-DDE, inverse associations with T(3) were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p(")-DDE and T(3) also remained.	Triiodothyronine	91-95	pyruvate carboxylase	Homo sapiens	126-129
17189629-6	2007	However, when results were additionally adjusted for p,p(")-DDE, inverse associations with T(3) were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p(")-DDE and T(3) also remained.	Triiodothyronine	91-95	pyruvate carboxylase	Homo sapiens	126-129
17356046-3	2007	Hemizygous mutations have been identified in the X-linked MCT8 gene in boys with severe psychomotor retardation and elevated serum T(3) levels.	Triiodothyronine	131-135	solute carrier family 16 member 2	Homo sapiens	58-62
17356046-8	2007	CONCLUSION: These findings support the hypothesis that the severe psychomotor retardation and elevated serum T(3) levels in these patients are caused by inactivation of the MCT8 transporter, preventing action and metabolism of T(3) in central neurons.	Triiodothyronine	109-113	solute carrier family 16 member 2	Homo sapiens	173-177
17389703-3	2007	OBJECTIVE: Our objective was to assess the role of iodothyronine deiodinase type 1 (D1) and type 2 (D2) for T(3) production and to estimate the sources of T(3) in hyperthyroidism.	Triiodothyronine	108-112	leiomodin 1	Homo sapiens	51-86
17356046-8	2007	CONCLUSION: These findings support the hypothesis that the severe psychomotor retardation and elevated serum T(3) levels in these patients are caused by inactivation of the MCT8 transporter, preventing action and metabolism of T(3) in central neurons.	Triiodothyronine	227-231	solute carrier family 16 member 2	Homo sapiens	173-177
17321637-8	2007	We also demonstrated that triiodothyronine administration to rats causes NF-kappaB activation, but persistent exposure (10 days) to triiodothyronine deactivates NF-kappaB leading to sustained c-Jun N-terminal kinase (JNK) activation.	Triiodothyronine	132-148	mitogen-activated protein kinase 8	Rattus norvegicus	192-215
17627259-0	2007	The prevalence of autoantibodies to: myosin, troponin, tropomyosin and myoglobin in patients with circulating triiodothyronine and thyroxine autoantibodies (THAA).	Triiodothyronine	110-126	myosin heavy chain 14	Homo sapiens	37-43
17627259-0	2007	The prevalence of autoantibodies to: myosin, troponin, tropomyosin and myoglobin in patients with circulating triiodothyronine and thyroxine autoantibodies (THAA).	Triiodothyronine	110-126	myoglobin	Homo sapiens	71-80
17485832-0	2007	Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period.	Triiodothyronine	0-16	solute carrier family 2 member 5	Rattus norvegicus	74-79
17485832-0	2007	Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period.	Triiodothyronine	18-20	solute carrier family 2 member 5	Rattus norvegicus	74-79
17485832-1	2007	Jejunal GLUT5 is elevated with triiodothyronine (T(3)) during weaning of rats.	Triiodothyronine	31-47	solute carrier family 2 member 5	Rattus norvegicus	8-13
17485832-1	2007	Jejunal GLUT5 is elevated with triiodothyronine (T(3)) during weaning of rats.	Triiodothyronine	49-53	solute carrier family 2 member 5	Rattus norvegicus	8-13
17485832-2	2007	A perfusion of fructose into the small intestine of T(3)-injected rats at 21 d induced expression of the GLUT5 gene, but one into that of vehicle-injected rats did not.	Triiodothyronine	52-56	solute carrier family 2 member 5	Rattus norvegicus	105-110
17485832-3	2007	These results suggest that T(3) and fructose coordinately enhance jejunal expression of the GLUT5 gene in rats during weaning period.	Triiodothyronine	27-31	solute carrier family 2 member 5	Rattus norvegicus	92-97
17321637-8	2007	We also demonstrated that triiodothyronine administration to rats causes NF-kappaB activation, but persistent exposure (10 days) to triiodothyronine deactivates NF-kappaB leading to sustained c-Jun N-terminal kinase (JNK) activation.	Triiodothyronine	132-148	mitogen-activated protein kinase 8	Rattus norvegicus	217-220
17215160-7	2007	Thyrotropin-releasing hormone (TRH) stimulated, while thyroid hormones, triiodothyronine (T(3)) and thyroxine (T(4)), inhibited the TSHbeta mRNA levels, in dose-related manners.	Triiodothyronine	72-88	thyrotropin subunit beta	Anas platyrhynchos	132-139
17242407-7	2007	Chromatin immunoprecipitation studies confirmed that unliganded TR.RXR recruits both complexes to the triiodothyronine-responsive region of growth hormone gene in vivo.	Triiodothyronine	102-118	retinoid X receptor alpha	Homo sapiens	67-70
17242407-7	2007	Chromatin immunoprecipitation studies confirmed that unliganded TR.RXR recruits both complexes to the triiodothyronine-responsive region of growth hormone gene in vivo.	Triiodothyronine	102-118	growth hormone 1	Homo sapiens	140-154
17275272-9	2007	MMP-1 activity in the serum and left ventricle was higher with reduced levels of TIMPs-3 and -4 in the left ventricle of triiodothyronine-treated rats.	Triiodothyronine	121-137	matrix metallopeptidase 1	Rattus norvegicus	0-5
17275272-9	2007	MMP-1 activity in the serum and left ventricle was higher with reduced levels of TIMPs-3 and -4 in the left ventricle of triiodothyronine-treated rats.	Triiodothyronine	121-137	TIMP metallopeptidase inhibitor 3	Rattus norvegicus	81-95
17264173-6	2007	CRYM knockout loses the reduced nicotinamide adenine dinucleotide phosphate-dependent T(3) binding activity in the cytosol of the brain, kidney, heart, and liver.	Triiodothyronine	86-90	crystallin, mu	Mus musculus	0-4
17264173-9	2007	When radiolabeled T(3) is injected intravenously, labeled T(3) rapidly enters into and then escapes from the tissues in CRYM-knockout mice.	Triiodothyronine	18-22	crystallin, mu	Mus musculus	120-124
17264173-9	2007	When radiolabeled T(3) is injected intravenously, labeled T(3) rapidly enters into and then escapes from the tissues in CRYM-knockout mice.	Triiodothyronine	58-62	crystallin, mu	Mus musculus	120-124
17187421-7	2007	CONCLUSION: T(3) administration involving transient oxidative stress in the liver exerts significant protection against IR injury, a novel preconditioning maneuver that is associated with NF-kappaB and STAT3 activation and acute-phase response.	Triiodothyronine	12-16	signal transducer and activator of transcription 3	Rattus norvegicus	202-207
17224473-2	2007	Type 2 iodothyronine deiodinase is responsible for the conversion of thyroxine to tri-iodothyronine for use in peripheral tissues.	Triiodothyronine	82-99	iodothyronine deiodinase 2	Homo sapiens	0-31
17318265-2	2007	The MCT8-null mice described here, however, developed without overt deficits but also exhibited distorted 3,5,3"-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1).	Triiodothyronine	106-129	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	4-8
17318265-2	2007	The MCT8-null mice described here, however, developed without overt deficits but also exhibited distorted 3,5,3"-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1).	Triiodothyronine	131-133	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	4-8
17234839-12	2007	Several positional candidate genes within the QTL region for metabolic traits at the 1% chromosome-wise significance level are biologically associated with the regulation of metabolic pathways of insulin, triiodothyronine, and thyroxine.	Triiodothyronine	205-221	insulin	Gallus gallus	196-203
17242435-1	2007	Human cytosolic 3,5,3"-triiodo-L-thyronine-binding protein, also called mu-crystallin or CRYM, plays important physiological roles in transporting 3,5,3"-triiodo-L-thyronine (T(3)) into nuclei and regulating thyroid-hormone-related gene expression.	Triiodothyronine	16-42	crystallin mu	Homo sapiens	89-93
17242435-8	2007	Finally, a putative T(3)-binding site in human CRYM is proposed based on comparison with structural homologs.	Triiodothyronine	20-24	crystallin mu	Homo sapiens	47-51
17541266-6	2007	At 4 months, total T(3) concentrations increased in ZD1, while all thyroid hormone concentrations increased in ZD2.	Triiodothyronine	19-23	ZD1	Homo sapiens	52-55
17982271-4	2007	In this report, we show that Pitx2"s expression is markedly reduced in hypothyroid ovary as well as in ovarian granulosa cells, which is recovered with T(3)-supplementation both in vitro and in vivo conditions.	Triiodothyronine	152-156	paired-like homeodomain 2	Rattus norvegicus	29-34
17982271-6	2007	We have also observed similar pattern of expression of Pitx1 and -3 in hypothyroid and T(3)-supplemented ovaries.	Triiodothyronine	87-91	paired-like homeodomain 1	Rattus norvegicus	55-67
17287406-7	2007	A low free triiodothyronine was weakly associated with a low GH score (P < 0.02) and elevated thyrotropin receptor antibody with a low physical component summary (P < 0.02).	Triiodothyronine	11-27	thyroid stimulating hormone receptor	Homo sapiens	97-117
17174366-1	2007	Thyroid hormone (l-thyroxine, T(4), or 3,5,3"-triiodo-l-thyronine, T(3)) treatment of human papillary and follicular thyroid cancer cell lines resulted in enhanced cell proliferation, measured by proliferating cell nuclear antigen (PCNA).	Triiodothyronine	39-65	proliferating cell nuclear antigen	Homo sapiens	196-230
17174366-1	2007	Thyroid hormone (l-thyroxine, T(4), or 3,5,3"-triiodo-l-thyronine, T(3)) treatment of human papillary and follicular thyroid cancer cell lines resulted in enhanced cell proliferation, measured by proliferating cell nuclear antigen (PCNA).	Triiodothyronine	39-65	proliferating cell nuclear antigen	Homo sapiens	232-236
17174366-1	2007	Thyroid hormone (l-thyroxine, T(4), or 3,5,3"-triiodo-l-thyronine, T(3)) treatment of human papillary and follicular thyroid cancer cell lines resulted in enhanced cell proliferation, measured by proliferating cell nuclear antigen (PCNA).	Triiodothyronine	67-72	proliferating cell nuclear antigen	Homo sapiens	196-230
17174366-1	2007	Thyroid hormone (l-thyroxine, T(4), or 3,5,3"-triiodo-l-thyronine, T(3)) treatment of human papillary and follicular thyroid cancer cell lines resulted in enhanced cell proliferation, measured by proliferating cell nuclear antigen (PCNA).	Triiodothyronine	67-72	proliferating cell nuclear antigen	Homo sapiens	232-236
17053029-3	2007	Here we report the effects of T(3) on PIPPin expression in developing rat brain.	Triiodothyronine	30-34	cold shock domain containing C2	Rattus norvegicus	38-44
17161219-6	2007	Serum adiponectin had a positive correlation with serum thyroxine (r = .81, P < .001) and triiodothyronine (r = 0.68, P = .03) and a negative correlation with serum thyroid-stimulating hormone (P = -.62, r = 0.015).	Triiodothyronine	93-109	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	6-17
18174701-2	2007	Among these, monocarboxylate transporter 8 (MCT8) shows particularly high activity towards the active thyroid hormone 3,3",5-triiodothyronine (T(3)).	Triiodothyronine	118-141	solute carrier family 16 member 2	Homo sapiens	13-42
18174701-2	2007	Among these, monocarboxylate transporter 8 (MCT8) shows particularly high activity towards the active thyroid hormone 3,3",5-triiodothyronine (T(3)).	Triiodothyronine	118-141	solute carrier family 16 member 2	Homo sapiens	44-48
18174701-2	2007	Among these, monocarboxylate transporter 8 (MCT8) shows particularly high activity towards the active thyroid hormone 3,3",5-triiodothyronine (T(3)).	Triiodothyronine	143-147	solute carrier family 16 member 2	Homo sapiens	13-42
18174701-2	2007	Among these, monocarboxylate transporter 8 (MCT8) shows particularly high activity towards the active thyroid hormone 3,3",5-triiodothyronine (T(3)).	Triiodothyronine	143-147	solute carrier family 16 member 2	Homo sapiens	44-48
18174701-5	2007	CONCLUSIONS: Mutations in MCT8 have been identified in boys with severe psychomotor retardation who also have very high serum T(3) levels.	Triiodothyronine	126-130	solute carrier family 16 member 2	Homo sapiens	26-30
17210748-0	2007	Triiodothyronine modulates the expression of aquaporin-8 in rat liver mitochondria.	Triiodothyronine	0-16	aquaporin 8	Rattus norvegicus	45-56
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	36-61	thyroid hormone receptor alpha	Mus musculus	96-104
17088414-1	2006	The present study demonstrates that 3,5,3"-tri-iodothyronine (T3) in physiological dose range inhibits tumor necrosis factor alpha(TNFalpha)/Fas-induced apoptosis in mouse hepatocytes.	Triiodothyronine	62-64	tumor necrosis factor	Mus musculus	103-130
17088414-1	2006	The present study demonstrates that 3,5,3"-tri-iodothyronine (T3) in physiological dose range inhibits tumor necrosis factor alpha(TNFalpha)/Fas-induced apoptosis in mouse hepatocytes.	Triiodothyronine	62-64	tumor necrosis factor	Mus musculus	131-139
16873538-3	2006	Dio2 is believed to control the local synthesis of bioactive T(3) to regulate gonadal response.	Triiodothyronine	61-65	LOW QUALITY PROTEIN: type II iodothyronine deiodinase	Mesocricetus auratus	0-4
16870170-1	2006	Synthesis of tri-iodothyronine (T(3)) and thyroxine (T(4)) follows a metabolic pathway that depends on the integrity of the thyroglobulin structure.	Triiodothyronine	13-30	thyroglobulin	Homo sapiens	124-137
16870170-1	2006	Synthesis of tri-iodothyronine (T(3)) and thyroxine (T(4)) follows a metabolic pathway that depends on the integrity of the thyroglobulin structure.	Triiodothyronine	32-36	thyroglobulin	Homo sapiens	124-137
16905155-1	2006	We investigated effects of different concentrations (10(-7) - 10(-5) M) of bisphenol A (BPA), which is known as an estrogenic and anti-thyroid hormonal endocrine disrupter, on the expression of thyroid hormone receptor (TR) alpha and beta and retinoid X receptor (RXR) gamma mRNA in tails of stage 52-54 Xenopus tadpoles in organ culture in the presence or absence of different concentrations of triiodo-thyronine (T(3)).	Triiodothyronine	396-413	thyroid hormone receptor alpha L homeolog	Xenopus laevis	194-229
16905155-7	2006	Gene expression of RXRgamma, a partner for heterodimer formation of TRs, was supressed by T(3) alone and also by BPA alone, but no additive effects were observed so far as studied.	Triiodothyronine	90-94	retinoid X receptor gamma L homeolog	Xenopus laevis	19-27
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	36-61	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	114-122
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	36-61	thymoma viral proto-oncogene 1	Mus musculus	195-198
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	36-61	nitric oxide synthase 3, endothelial cell	Mus musculus	203-236
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	63-65	thyroid hormone receptor alpha	Mus musculus	96-104
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	63-65	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	114-122
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	63-65	thymoma viral proto-oncogene 1	Mus musculus	195-198
16966610-5	2006	Treatment of endothelial cells with L-3,5,3"-triiodothyronine (T3) increased the association of TRalpha1 with the p85alpha subunit of PI3-kinase, leading to the phosphorylation and activation of Akt and endothelial nitric oxide synthase (eNOS).	Triiodothyronine	63-65	nitric oxide synthase 3, endothelial cell	Mus musculus	203-236
16115698-1	2006	The effects of ethanol consumption and ageing were investigated on the expression levels of retinoic acid (RA) and triiodothyronine (T3) nuclear receptors (RAR, RXR and TR) and of associated target genes involved in synaptic plasticity, neurogranin (RC3) and neuromodulin (GAP-43) in mice brain.	Triiodothyronine	115-131	retinoic acid receptor, alpha	Mus musculus	156-159
16936513-1	2006	It is well known that under physiological conditions, the Tg molecule is the substrate for the hormones triiodothyronine and thyroxine.	Triiodothyronine	104-120	thyroglobulin	Homo sapiens	58-60
16957765-0	2006	Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8.	Triiodothyronine	56-58	solute carrier family 16 member 2	Homo sapiens	89-118
16957765-6	2006	MCT8 seems to be especially important for the uptake of active hormone T3 into neurons, which is essential for optimal brain development.	Triiodothyronine	71-73	solute carrier family 16 member 2	Homo sapiens	0-4
16794221-6	2006	Administration of T3 (100 microg/100 g for 14 days) to rats attenuated neointimal formation after balloon injury of carotid artery with reduced CREB activation and BrdU incorporation.	Triiodothyronine	18-20	cAMP responsive element binding protein 1	Rattus norvegicus	144-148
16879610-4	2006	Analysis of the binding affinity to thyroid hormones of recombinant human TTR showed a dissociation constant (Kd) for triiodothyronine (T3) of 53.26+/-3.97 nM and for thyroxine (T4) of 19.73+/-0.13 nM.	Triiodothyronine	118-134	transthyretin	Homo sapiens	74-77
16879610-4	2006	Analysis of the binding affinity to thyroid hormones of recombinant human TTR showed a dissociation constant (Kd) for triiodothyronine (T3) of 53.26+/-3.97 nM and for thyroxine (T4) of 19.73+/-0.13 nM.	Triiodothyronine	136-138	transthyretin	Homo sapiens	74-77
17111039-0	2006	Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression.	Triiodothyronine	11-28	myosin heavy chain 7	Rattus norvegicus	101-124
16624326-0	2006	Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue.	Triiodothyronine	14-30	leptin	Rattus norvegicus	51-57
16624326-0	2006	Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue.	Triiodothyronine	14-30	leptin	Rattus norvegicus	94-100
16624326-1	2006	Conflicting results have been reported regarding the effect of triiodothyronine (T(3)) on serum leptin and adipose tissue leptin gene expression in human and animals.	Triiodothyronine	63-79	leptin	Homo sapiens	96-102
16624326-1	2006	Conflicting results have been reported regarding the effect of triiodothyronine (T(3)) on serum leptin and adipose tissue leptin gene expression in human and animals.	Triiodothyronine	63-79	leptin	Homo sapiens	122-128
16624326-1	2006	Conflicting results have been reported regarding the effect of triiodothyronine (T(3)) on serum leptin and adipose tissue leptin gene expression in human and animals.	Triiodothyronine	81-85	leptin	Homo sapiens	96-102
16624326-1	2006	Conflicting results have been reported regarding the effect of triiodothyronine (T(3)) on serum leptin and adipose tissue leptin gene expression in human and animals.	Triiodothyronine	81-85	leptin	Homo sapiens	122-128
16624326-2	2006	The aim of the present study was to evaluate the effect of administration of increasing doses of T(3) on serum leptin concentration and on leptin mRNA abundance in white adipose tissue of rats.	Triiodothyronine	97-101	leptin	Rattus norvegicus	111-117
16624326-2	2006	The aim of the present study was to evaluate the effect of administration of increasing doses of T(3) on serum leptin concentration and on leptin mRNA abundance in white adipose tissue of rats.	Triiodothyronine	97-101	leptin	Rattus norvegicus	139-145
16624326-3	2006	The results presented in this paper indicate that administration of single different doses of T(3) to euthyroid rats resulted dose dependent increases of serum total T(3) concentrations which are associated with a decrease in white adipose tissue leptin mRNA level.	Triiodothyronine	94-98	leptin	Rattus norvegicus	247-253
16624326-5	2006	Like white adipose tissue leptin mRNA level, serum leptin concentration decreased after T(3) administration, and was also negatively correlated with the serum T(3) concentration (r=-0.8, p<0.001).	Triiodothyronine	88-92	leptin	Rattus norvegicus	51-57
16624326-5	2006	Like white adipose tissue leptin mRNA level, serum leptin concentration decreased after T(3) administration, and was also negatively correlated with the serum T(3) concentration (r=-0.8, p<0.001).	Triiodothyronine	159-163	leptin	Rattus norvegicus	51-57
16786588-7	2006	The cleavage of BIDGFP fusion protein during natural or T(3)-induced metamorphosis was specifically inhibited by caspase-8 inhibitors.	Triiodothyronine	56-60	caspase 8 L homeolog	Xenopus laevis	113-122
16581179-9	2006	In all, our data show that the regulation of GLUT1 and GLUT3 in cerebral cortex is regulated by T(3) in a complex way and suggest that alterations in the expression of glucose transporters induced by hypothyroidism might have a functional impact on brain glucose uptake.	Triiodothyronine	96-100	solute carrier family 2 member 1	Rattus norvegicus	45-50
16626768-7	2006	Treatment with Pyrethrins and NaPB increased hepatic microsomal thyroxine UDPglucuronosyltransferase activity and serum thyroid stimulating hormone levels (TSH), but reduced serum levels of either thyroxine (T4) and/or triiodothyronine (T3).	Triiodothyronine	219-235	NSF attachment protein beta	Rattus norvegicus	30-34
16626768-7	2006	Treatment with Pyrethrins and NaPB increased hepatic microsomal thyroxine UDPglucuronosyltransferase activity and serum thyroid stimulating hormone levels (TSH), but reduced serum levels of either thyroxine (T4) and/or triiodothyronine (T3).	Triiodothyronine	237-239	NSF attachment protein beta	Rattus norvegicus	30-34
16849576-6	2006	The thyroid hormone 3,5,3"-triiodo-L-thyronine (T3) and T4 were equipotent stimulators of PCNA accumulation in C6, F98, and GL261 cells, but physiologic concentrations of T3 are 50-fold lower than those of T4.	Triiodothyronine	48-50	proliferating cell nuclear antigen	Rattus norvegicus	90-94
16627555-3	2006	Structures with a bromine in either ortho positions with respect to the hydroxy group competed more efficiently with T(3) binding to xTTR and the xTR LBD.	Triiodothyronine	117-121	transthyretin S homeolog	Xenopus laevis	133-137
16627555-3	2006	Structures with a bromine in either ortho positions with respect to the hydroxy group competed more efficiently with T(3) binding to xTTR and the xTR LBD.	Triiodothyronine	117-121	thyroid hormone receptor, beta L homeolog	Xenopus laevis	146-149
16627555-7	2006	Our results suggest that 3,3",5-tribromobisphenol A affects T(3) binding to xTTR and xTR and that it interferes with the intracellular T(3) signaling pathway.	Triiodothyronine	60-64	transthyretin S homeolog	Xenopus laevis	76-80
16627555-7	2006	Our results suggest that 3,3",5-tribromobisphenol A affects T(3) binding to xTTR and xTR and that it interferes with the intracellular T(3) signaling pathway.	Triiodothyronine	60-64	thyroid hormone receptor, beta L homeolog	Xenopus laevis	85-88
16949834-9	2006	These results are possibly attributable to the inhibitory effect of IL6 on deiodination of T(3) and imply a role for IL6 in determining thyroxine replacement dose among these patients.	Triiodothyronine	91-95	interleukin 6	Homo sapiens	68-71
16601143-2	2006	Previous studies indicated that coordinated development in frogs requires tissue and stage-dependent type II and type III iodothyronine deiodinase expression patterns to obtain requisite levels of intracellular T(3) in tissues at the appropriate stages of metamorphosis.	Triiodothyronine	211-215	deiodinase, iodothyronine, type 3 L homeolog	Xenopus laevis	85-146
16581179-9	2006	In all, our data show that the regulation of GLUT1 and GLUT3 in cerebral cortex is regulated by T(3) in a complex way and suggest that alterations in the expression of glucose transporters induced by hypothyroidism might have a functional impact on brain glucose uptake.	Triiodothyronine	96-100	solute carrier family 2 member 3	Rattus norvegicus	55-60
15980113-4	2006	Pathogenic mutations in the MCT8 gene, which encodes a thyroid hormone transporter, results in elevated serum triiodothyronine (T3) levels, which were confirmed in four affected males of this family, while normal levels were found among obligate carriers.	Triiodothyronine	110-126	solute carrier family 16 member 2	Homo sapiens	28-32
16543366-8	2006	Importantly, the binding activity of L-T3 and 17beta-estradiol hormones to PDI was competitively inhibited by BPA in addition to abolishing its isomerase activities.	Triiodothyronine	37-41	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	75-78
16469813-5	2006	Cycloheximide inhibited T(3)-induced SULT2A1 expression, suggesting that regulation was indirect.	Triiodothyronine	24-28	sulfotransferase family 2A member 1	Homo sapiens	37-44
16469813-11	2006	The -228 SF1 binding site was identified as the most critical site because deleting this region reduced T(3)-induced expression.	Triiodothyronine	104-108	nuclear receptor subfamily 5 group A member 1	Homo sapiens	9-12
16469813-13	2006	SULT2A1 and SF1 up-regulation at protein and RNA levels in thyroidectomized rats occurred after T(3) application.	Triiodothyronine	96-100	sulfotransferase family 2A member 1	Rattus norvegicus	0-7
16469813-13	2006	SULT2A1 and SF1 up-regulation at protein and RNA levels in thyroidectomized rats occurred after T(3) application.	Triiodothyronine	96-100	splicing factor 1	Rattus norvegicus	12-15
16741045-11	2006	Pearson"s correlation revealed that plasma ET-1 levels positively correlated with serum triiodothyronine (T3) and free thyroxine (FT4) levels.	Triiodothyronine	88-104	endothelin 1	Homo sapiens	43-47
16741045-11	2006	Pearson"s correlation revealed that plasma ET-1 levels positively correlated with serum triiodothyronine (T3) and free thyroxine (FT4) levels.	Triiodothyronine	106-108	endothelin 1	Homo sapiens	43-47
15980113-4	2006	Pathogenic mutations in the MCT8 gene, which encodes a thyroid hormone transporter, results in elevated serum triiodothyronine (T3) levels, which were confirmed in four affected males of this family, while normal levels were found among obligate carriers.	Triiodothyronine	128-130	solute carrier family 16 member 2	Homo sapiens	28-32
16566928-0	2006	Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium.	Triiodothyronine	58-74	sarcolipin	Rattus norvegicus	39-49
16566928-4	2006	The expression of sarcolipin mRNA was significantly decreased in the atria of mice with hyperthyroidism and in 3,5,3"-triiodo-l-thyronine-treated neonatal rat atrial myocytes.	Triiodothyronine	111-137	sarcolipin	Mus musculus	18-28
16298169-8	2006	In conclusion, T(3)-induced oxidative stress in the liver enhances the DNA-binding of NF-kappaB and the NF-kappaB-dependent expression of cytokines and iNOS by actions primarily exerted at the Kupffer cell level.	Triiodothyronine	15-19	nuclear factor kappa B subunit 1	Homo sapiens	86-95
16040072-4	2006	Treatment of premetamorphic tadpoles with 1 nM 3,5,3"-triiodothyronine (T3) caused a rapid induction of TRbetaA mRNA in head and tail tissue within 6 to 12 h which was maintained for at least 72 h after initiation of T3 treatment.	Triiodothyronine	47-70	trbeta-A	Xenopus laevis	104-111
16040072-4	2006	Treatment of premetamorphic tadpoles with 1 nM 3,5,3"-triiodothyronine (T3) caused a rapid induction of TRbetaA mRNA in head and tail tissue within 6 to 12 h which was maintained for at least 72 h after initiation of T3 treatment.	Triiodothyronine	72-74	trbeta-A	Xenopus laevis	104-111
16384862-4	2006	The proangiogenesis effect of DITPA was inhibited by tetraiodothyroacetic acid, a thyroid hormone analog that competes with T(4) and T(3) for a novel cell surface hormone receptor site on integrin alphavbeta3.	Triiodothyronine	133-137	integrin subunit alpha V	Homo sapiens	188-208
16298169-8	2006	In conclusion, T(3)-induced oxidative stress in the liver enhances the DNA-binding of NF-kappaB and the NF-kappaB-dependent expression of cytokines and iNOS by actions primarily exerted at the Kupffer cell level.	Triiodothyronine	15-19	nuclear factor kappa B subunit 1	Homo sapiens	104-113
16298169-8	2006	In conclusion, T(3)-induced oxidative stress in the liver enhances the DNA-binding of NF-kappaB and the NF-kappaB-dependent expression of cytokines and iNOS by actions primarily exerted at the Kupffer cell level.	Triiodothyronine	15-19	inositol-3-phosphate synthase 1	Homo sapiens	152-156
16260782-6	2006	triiodothyronine replacement restored CYP7A1 mRNA levels in WT mice but had minimal effect in MUT mice.	Triiodothyronine	0-16	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	38-44
16883675-1	2006	The use of sustained release tri-iodothyronine (SR-T3) in clinical practice, has gained popularity in the complementary and alternative medical community in the treatment of chronic fatigue with a protocol (WT3) pioneered by Dr. Denis Wilson.	Triiodothyronine	29-46	WT3	Homo sapiens	207-210
16690458-11	2006	Within the study group of patients, baseline PICP, osteocalcin, and ICTP demonstrated positive correlation trends with free triiodothyronine and free thyroxine.	Triiodothyronine	124-140	bone gamma-carboxyglutamate protein	Homo sapiens	51-62
16687304-4	2006	Recent investigations of Japanese quail show that long-day-induced type 2 deiodinase (Dio2) expression in the mediobasal hypothalamus (MBH) plays an important role in the photoperiodic gonadal regulation by catalyzing the conversion of the prohormone thyroxine (T(4)) to bioactive 3,5,3"-triiodothyronine (T3).	Triiodothyronine	306-308	type II iodothyronine deiodinase	Coturnix japonica	86-90
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	354-359
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	361-366
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	E2F transcription factor 1	Homo sapiens	368-372
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	muscular LMNA interacting protein	Homo sapiens	384-387
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	cyclin dependent kinase 2	Homo sapiens	402-406
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	tumor protein p53	Homo sapiens	423-426
17115080-1	2006	In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-beta), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1).	Triiodothyronine	56-72	MDM2 proto-oncogene	Homo sapiens	437-441
16155104-10	2006	PKC alpha overexpression in cardiomyocytes caused marked repression of triiodothyronine (T3)-responsive genes, alpha-myosin heavy chain, and the sarcoplasmic reticulum calcium-activated adenosinetriphosphatase SERCA2.	Triiodothyronine	71-87	protein kinase C, alpha	Rattus norvegicus	0-9
16155104-10	2006	PKC alpha overexpression in cardiomyocytes caused marked repression of triiodothyronine (T3)-responsive genes, alpha-myosin heavy chain, and the sarcoplasmic reticulum calcium-activated adenosinetriphosphatase SERCA2.	Triiodothyronine	89-91	protein kinase C, alpha	Rattus norvegicus	0-9
16733789-1	2006	The aim of present study was to investigate the effects of 3,3",5-triiodothyronine (T(3)) on rat testis both morphometrically and immunohistochemically with determining of insulin-like growth factor I (IGF-I) expression.	Triiodothyronine	84-88	insulin-like growth factor 1	Rattus norvegicus	202-207
16394271-2	2006	Here we show by Northern blot, Western analysis, and immunohistochemistry that 3,5,3"-triiodothyronine (T3) treatment of adult rats caused an increase of cyclin D1 mRNA and protein levels.	Triiodothyronine	104-106	cyclin D1	Rattus norvegicus	154-163
16477365-12	2006	Normal triiodothyronine and low thyroxine concentrations are often observed in patients with thyroglobulin gene mutations.	Triiodothyronine	7-23	thyroglobulin	Homo sapiens	93-106
16477365-13	2006	We considered that some patients with thyroglobulin abnormality might have high triiodothyronine levels.	Triiodothyronine	80-96	thyroglobulin	Homo sapiens	38-51
16477365-0	2006	A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels.	Triiodothyronine	129-145	thyroglobulin	Homo sapiens	46-59
17090972-3	2006	In MtT/S cells, triiodothyronine (T3), all-trans retinoic acid (RA) and 9-cis retinoic acid (9cRA) stimulated GH promoter activity but dexamethasone (DEX) did not.	Triiodothyronine	16-32	gonadotropin releasing hormone receptor	Rattus norvegicus	110-112
17090972-3	2006	In MtT/S cells, triiodothyronine (T3), all-trans retinoic acid (RA) and 9-cis retinoic acid (9cRA) stimulated GH promoter activity but dexamethasone (DEX) did not.	Triiodothyronine	34-36	gonadotropin releasing hormone receptor	Rattus norvegicus	110-112
17177635-2	2006	Our findings show that in the EDL muscle, all four types 1, 2a, 2x/d and 2b of MyHC mRNA transcripts and protein isoforms are present in euthyroid, hypothyroid and hyperthyroid rats, i.e. after chronic treatment with methimazole and T(3), respectively.	Triiodothyronine	233-237	myosin heavy chain 13	Rattus norvegicus	79-83
16179385-5	2005	The inhibitory characteristics of these chemicals were similar for both assays performed, although the assay for T(3)-dependent activation of TRbeta gene was more sensitive than the luciferase assay.	Triiodothyronine	113-117	thyroid hormone receptor, beta S homeolog	Xenopus laevis	142-148
16150908-6	2005	FGFR3 expression was also increased in cells treated with T(3) for 21 d, when T(3) induced an earlier onset of hypertrophic differentiation and collagen X expression.	Triiodothyronine	58-62	fibroblast growth factor receptor 3	Mus musculus	0-5
16150908-6	2005	FGFR3 expression was also increased in cells treated with T(3) for 21 d, when T(3) induced an earlier onset of hypertrophic differentiation and collagen X expression.	Triiodothyronine	78-82	fibroblast growth factor receptor 3	Mus musculus	0-5
16265595-7	2005	Hypothyroid animals treated with T3 (5 microg/day for 6 days) or statin (0.2 mg/30 g for 2 weeks) reduce blood lipids and aortic OPN mRNA expression.	Triiodothyronine	33-35	secreted phosphoprotein 1	Mus musculus	129-132
16322164-6	2005	RESULTS: The nonosmotic stimuli of ADH secretion that we identified were vomiting (50 of 52), dehydration (median: 5%; range: 3-8%), hypoglycemia (2 of 52), and raised hormonal markers of stress (mean +/- SD: cortisol, 1094 +/- 589 nmol/L; reverse triiodothyronine, 792 +/- 293 pmol/L).	Triiodothyronine	248-264	arginine vasopressin	Homo sapiens	35-38
16617682-3	2005	PDI plays a key role in protein folding as an isomerase and also possesses a 3,3",5-triiodo-L-thyronine (T3)-binding activity.	Triiodothyronine	77-103	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-3
16617682-3	2005	PDI plays a key role in protein folding as an isomerase and also possesses a 3,3",5-triiodo-L-thyronine (T3)-binding activity.	Triiodothyronine	105-107	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-3
15980170-5	2005	We find that the natural ligand 3,5,3"-triiodo-L-thyronine (T(3)) dissociates from the TRalpha1 LBD along three competing pathways generated through i), opening of helix (H) 12; ii), separation of H8 and H11 and the Omega-loop between H2 and H3; and iii), opening of H2 and H3, and the intervening beta-strand.	Triiodothyronine	32-58	H1.1 linker histone, cluster member	Homo sapiens	197-207
15985269-3	2005	However, little is known about the effect of 3,5,3"-triiodo-L-thyronine (T3) on the intermediate filament (IF) vimentin in rat testes.	Triiodothyronine	73-75	vimentin	Rattus norvegicus	111-119
15980170-5	2005	We find that the natural ligand 3,5,3"-triiodo-L-thyronine (T(3)) dissociates from the TRalpha1 LBD along three competing pathways generated through i), opening of helix (H) 12; ii), separation of H8 and H11 and the Omega-loop between H2 and H3; and iii), opening of H2 and H3, and the intervening beta-strand.	Triiodothyronine	60-64	H1.1 linker histone, cluster member	Homo sapiens	197-207
16135236-7	2005	These data indicate that the YscF needle is a multifunctional structure that participates in virulence protein secretion, in translocation of virulence proteins across eukaryotic membranes and in the cell contact- and calcium-dependent regulation of T3S.	Triiodothyronine	250-253	type III secretion protein	Yersinia pestis	29-33
16135673-1	2005	Recently, we demonstrated that 3,3",5-triiodothyronine (T3) induces oxidative stress in rat liver, with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the NF-kappaB-dependent expression of tumor necrosis factor-alpha (TNF-alpha).	Triiodothyronine	56-58	tumor necrosis factor	Rattus norvegicus	214-241
16135673-1	2005	Recently, we demonstrated that 3,3",5-triiodothyronine (T3) induces oxidative stress in rat liver, with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the NF-kappaB-dependent expression of tumor necrosis factor-alpha (TNF-alpha).	Triiodothyronine	56-58	tumor necrosis factor	Rattus norvegicus	243-252
15947969-1	2005	Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms alpha (TRalpha) and beta (TRbeta).	Triiodothyronine	0-16	thyroid hormone receptor beta	Rattus norvegicus	160-166
15961419-0	2005	Increased uncoupling protein-2 mRNA abundance and glucocorticoid action in adipose tissue in the sheep fetus during late gestation is dependent on plasma cortisol and triiodothyronine.	Triiodothyronine	167-183	mitochondrial uncoupling protein 2	Ovis aries	10-30
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	66-82	mitochondrial uncoupling protein 2	Ovis aries	121-125
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	66-82	glucocorticoid receptor	Ovis aries	127-150
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	66-82	glucocorticoid receptor	Ovis aries	152-154
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	66-82	11-beta-hydroxysteroid dehydrogenase 1	Ovis aries	204-214
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	66-82	11-beta-hydroxysteroid dehydrogenase type 2	Ovis aries	223-233
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	84-86	mitochondrial uncoupling protein 2	Ovis aries	121-125
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	84-86	glucocorticoid receptor	Ovis aries	127-150
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	84-86	glucocorticoid receptor	Ovis aries	152-154
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	84-86	11-beta-hydroxysteroid dehydrogenase 1	Ovis aries	204-214
15961419-2	2005	The present study aimed to determine if fetal plasma cortisol and triiodothyronine (T3) influenced the mRNA abundance of UCP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (11betaHSD2) in fetal adipose tissue in the sheep during late gestation.	Triiodothyronine	84-86	11-beta-hydroxysteroid dehydrogenase type 2	Ovis aries	223-233
15947969-1	2005	Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms alpha (TRalpha) and beta (TRbeta).	Triiodothyronine	18-20	thyroid hormone receptor beta	Rattus norvegicus	160-166
15941710-3	2005	Here we report that 3,5,3"-triiodo-L-thyronine (T3) and a synthetic thyroid receptor beta (TRbeta) ligand increase APOA5 mRNA and protein levels in hepatocytes.	Triiodothyronine	48-50	apolipoprotein A5	Homo sapiens	115-120
16131319-7	2005	Human MCT8 shows preference for T(3) as the ligand.	Triiodothyronine	32-36	solute carrier family 16 member 2	Homo sapiens	6-10
16131319-10	2005	Recently, mutations in MCT8 have been found to be associated with severe X-linked psychomotor retardation and strongly elevated serum T(3) levels.	Triiodothyronine	134-138	solute carrier family 16 member 2	Homo sapiens	23-27
16131324-3	2005	The expression of D2, an enzyme that synthesizes the active hormone triiodothyronine (T3) from its circulating precursor thyroxine (T4), accurately marks cells at the time that they undergo thyroid hormone-dependent changes.	Triiodothyronine	68-84	iodothyronine deiodinase 2	Homo sapiens	18-20
16131324-3	2005	The expression of D2, an enzyme that synthesizes the active hormone triiodothyronine (T3) from its circulating precursor thyroxine (T4), accurately marks cells at the time that they undergo thyroid hormone-dependent changes.	Triiodothyronine	86-88	iodothyronine deiodinase 2	Homo sapiens	18-20
16079076-4	2005	We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p -DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status.	Triiodothyronine	67-83	pyruvate carboxylase	Homo sapiens	125-128
16079076-4	2005	We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p -DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status.	Triiodothyronine	67-83	pyruvate carboxylase	Homo sapiens	134-137
16079076-4	2005	We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p -DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status.	Triiodothyronine	67-83	pyruvate carboxylase	Homo sapiens	134-137
15902420-4	2005	The effect of supplementing the culture medium with triiodothyronine (T3) on the response of rat hepatocytes to c-AMP was also investigated.	Triiodothyronine	52-68	cathelicidin antimicrobial peptide	Rattus norvegicus	112-117
15902420-4	2005	The effect of supplementing the culture medium with triiodothyronine (T3) on the response of rat hepatocytes to c-AMP was also investigated.	Triiodothyronine	70-72	cathelicidin antimicrobial peptide	Rattus norvegicus	112-117
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Triiodothyronine	14-33	epidermal growth factor	Mus musculus	87-110
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Triiodothyronine	14-33	epidermal growth factor	Mus musculus	112-115
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Triiodothyronine	35-37	epidermal growth factor	Mus musculus	87-110
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Triiodothyronine	35-37	epidermal growth factor	Mus musculus	112-115
15826771-9	2005	Expression of UCP3 was inhibited by growth hormone (100 ng/mL; P<0.05), tri-iodothyronine (10 nM; P<0.05) or leptin (100 ng/mL; P<0.05).	Triiodothyronine	75-92	uncoupling protein 3	Homo sapiens	14-18
15862991-2	2005	Resistance to thyroid hormone (RTH) is a genetic disease associated with mutations to TRbeta that lack or show reduced responsiveness to thyroid hormone (triiodothyronine).	Triiodothyronine	154-170	T cell receptor beta locus	Homo sapiens	86-92
15708448-0	2005	Differential effect of retinoic acid and triiodothyronine on the age-related hypo-expression of neurogranin in rat.	Triiodothyronine	41-57	neurogranin	Rattus norvegicus	96-107
15891024-8	2005	Photoperiodic signal transduction may involve a clock-dependent local conversion of thyroxine to triiodothyronine (T(3)) in the medial basal hypothalamus mediated by increased expression of the gene encoding type 2 iodothyronine deiodinase.	Triiodothyronine	97-113	iodothyronine deiodinase 2	Homo sapiens	208-239
15891024-8	2005	Photoperiodic signal transduction may involve a clock-dependent local conversion of thyroxine to triiodothyronine (T(3)) in the medial basal hypothalamus mediated by increased expression of the gene encoding type 2 iodothyronine deiodinase.	Triiodothyronine	115-119	iodothyronine deiodinase 2	Homo sapiens	208-239
15891024-9	2005	This photoinduced increase in T(3) may stimulate the release of gonadotrophin-releasing hormone (GnRH) through thyroid hormone receptors in the median eminence.	Triiodothyronine	30-34	gonadotropin releasing hormone 1	Homo sapiens	97-101
15578571-8	2005	Stimulation by T3 led to an induction of both sense and antisense of alpha-MyHC and to a decrease of beta-MyHC sense and antisense.	Triiodothyronine	15-17	myosin heavy chain 13	Rattus norvegicus	75-79
15811071-5	2005	In fact, in the immature Sertoli cells, GLUT1 is up regulated by l-triiodothyronine (T(3)).	Triiodothyronine	65-83	solute carrier family 2 member 1	Rattus norvegicus	40-45
15811071-5	2005	In fact, in the immature Sertoli cells, GLUT1 is up regulated by l-triiodothyronine (T(3)).	Triiodothyronine	85-89	solute carrier family 2 member 1	Rattus norvegicus	40-45
16028366-2	2005	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3) triggers inducible nitric oxide synthase (iNOS) expression in rat liver by upstream mechanisms involving the inhibitor of kappa (Ikappa) kinase activation.	Triiodothyronine	40-65	nitric oxide synthase 2	Rattus norvegicus	80-111
16028366-2	2005	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3) triggers inducible nitric oxide synthase (iNOS) expression in rat liver by upstream mechanisms involving the inhibitor of kappa (Ikappa) kinase activation.	Triiodothyronine	40-65	nitric oxide synthase 2	Rattus norvegicus	113-117
16028366-2	2005	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3) triggers inducible nitric oxide synthase (iNOS) expression in rat liver by upstream mechanisms involving the inhibitor of kappa (Ikappa) kinase activation.	Triiodothyronine	67-69	nitric oxide synthase 2	Rattus norvegicus	80-111
16028366-2	2005	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3) triggers inducible nitric oxide synthase (iNOS) expression in rat liver by upstream mechanisms involving the inhibitor of kappa (Ikappa) kinase activation.	Triiodothyronine	67-69	nitric oxide synthase 2	Rattus norvegicus	113-117
15757654-2	2005	Since triiodothyronine (T3) stimulates lipid metabolism, UCP3 expression and mitochondrial uncoupling, we examined its effects on some biochemical pathways that may underlie UCP3-mediated uncoupling.	Triiodothyronine	24-26	uncoupling protein 3	Rattus norvegicus	57-61
15598685-11	2005	Large amounts of T(3) were required to dissociate homodimers of the mutant TRbeta bound to DNA.	Triiodothyronine	17-21	T cell receptor beta locus	Homo sapiens	75-81
15578571-8	2005	Stimulation by T3 led to an induction of both sense and antisense of alpha-MyHC and to a decrease of beta-MyHC sense and antisense.	Triiodothyronine	15-17	myosin heavy chain 13	Rattus norvegicus	106-110
15578571-11	2005	Results indicate a coregulation of sense and antisense MyHC RNA under stimulation of T3 and phenylephrine in neonatal cardiomyocytes.	Triiodothyronine	85-87	myosin heavy chain 13	Rattus norvegicus	55-59
15607531-2	2005	We have previously shown that triiodothyronine (T(3)) activates p38 mitogen-activated protein (MAP) kinase, resulting in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	30-46	mitogen-activated protein kinase 14	Mus musculus	64-67
15652358-4	2005	Cotransfection of S100A6 in cultured neonatal rat cardiac myocytes inhibits induction of the cardiac fetal gene promoters skeletal alpha-actin (skACT) and beta-myosin heavy chain (beta-MHC) by PDGF, PE, AII, and the prostaglandin F2alpha (PGF2alpha), induction of the S100B promoter by PE, and induction of the alpha-MHC promoter by triiodothyronine (T3).	Triiodothyronine	333-349	S100 calcium binding protein A6	Rattus norvegicus	18-24
15652358-4	2005	Cotransfection of S100A6 in cultured neonatal rat cardiac myocytes inhibits induction of the cardiac fetal gene promoters skeletal alpha-actin (skACT) and beta-myosin heavy chain (beta-MHC) by PDGF, PE, AII, and the prostaglandin F2alpha (PGF2alpha), induction of the S100B promoter by PE, and induction of the alpha-MHC promoter by triiodothyronine (T3).	Triiodothyronine	333-349	myosin heavy chain 7	Rattus norvegicus	180-188
15691884-1	2005	Type II 5" deiodinase (D2) activity produces triiodothyronine (T3) from thyroxine (T4) and is induced by cold and norepinephrine (NE) in brown adipose tissue.	Triiodothyronine	45-61	iodothyronine deiodinase 2	Rattus norvegicus	0-21
15691884-1	2005	Type II 5" deiodinase (D2) activity produces triiodothyronine (T3) from thyroxine (T4) and is induced by cold and norepinephrine (NE) in brown adipose tissue.	Triiodothyronine	63-65	iodothyronine deiodinase 2	Rattus norvegicus	0-21
15607531-2	2005	We have previously shown that triiodothyronine (T(3)) activates p38 mitogen-activated protein (MAP) kinase, resulting in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	30-46	bone gamma-carboxyglutamate protein 2	Mus musculus	138-149
15607531-2	2005	We have previously shown that triiodothyronine (T(3)) activates p38 mitogen-activated protein (MAP) kinase, resulting in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-53	mitogen-activated protein kinase 14	Mus musculus	64-67
15607531-2	2005	We have previously shown that triiodothyronine (T(3)) activates p38 mitogen-activated protein (MAP) kinase, resulting in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-53	bone gamma-carboxyglutamate protein 2	Mus musculus	138-149
15607531-8	2005	Pituitary adenylate cyclase-activating polypeptide (PACAP) significantly inhibited the T(3)-stimulated osteocalcin synthesis.	Triiodothyronine	87-91	adenylate cyclase activating polypeptide 1	Mus musculus	0-50
15607531-8	2005	Pituitary adenylate cyclase-activating polypeptide (PACAP) significantly inhibited the T(3)-stimulated osteocalcin synthesis.	Triiodothyronine	87-91	adenylate cyclase activating polypeptide 1	Mus musculus	52-57
15607531-8	2005	Pituitary adenylate cyclase-activating polypeptide (PACAP) significantly inhibited the T(3)-stimulated osteocalcin synthesis.	Triiodothyronine	87-91	bone gamma-carboxyglutamate protein 2	Mus musculus	103-114
16344112-13	2005	Thus, thyroxine deiodinase type II, an enzyme generating triiodothyronine (T(3)) from thyroxine, appears to be exclusively expressed by tanycytes, suggesting that these cells are the main source of brain T(3).	Triiodothyronine	57-73	iodothyronine deiodinase 2	Homo sapiens	6-34
15585599-2	2005	We previously showed that changes in thyroid status altered pituitary PC2 mRNA and that this regulation was due to triiodothyronine-dependent interaction of the thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large proximal region of the human PC2 promoter.	Triiodothyronine	115-131	proprotein convertase subtilisin/kexin type 2	Homo sapiens	70-73
15585599-2	2005	We previously showed that changes in thyroid status altered pituitary PC2 mRNA and that this regulation was due to triiodothyronine-dependent interaction of the thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large proximal region of the human PC2 promoter.	Triiodothyronine	115-131	proprotein convertase subtilisin/kexin type 2	Homo sapiens	297-300
15585599-4	2005	To address the mechanism of T3 regulation of the PC2 gene, we used human PC2 (hPC2) promoter constructs transiently transfected into GH3 cells and found that triiodothyronine negatively and 9-cis-retinoic acid positively regulated hPC2 promoter activity.	Triiodothyronine	158-174	proprotein convertase subtilisin/kexin type 2	Homo sapiens	49-52
15585599-4	2005	To address the mechanism of T3 regulation of the PC2 gene, we used human PC2 (hPC2) promoter constructs transiently transfected into GH3 cells and found that triiodothyronine negatively and 9-cis-retinoic acid positively regulated hPC2 promoter activity.	Triiodothyronine	158-174	proprotein convertase subtilisin/kexin type 2	Homo sapiens	73-76
15585599-4	2005	To address the mechanism of T3 regulation of the PC2 gene, we used human PC2 (hPC2) promoter constructs transiently transfected into GH3 cells and found that triiodothyronine negatively and 9-cis-retinoic acid positively regulated hPC2 promoter activity.	Triiodothyronine	158-174	proprotein convertase subtilisin/kexin type 2	Homo sapiens	78-82
16326644-9	2005	Following T(3)-treatment (8.98 microg mL(-1)) of the BNL 1ME A.7R.1 liver cancer cells, 24.62%, 25.53% and 44.90% of the cells showed elevated active caspase 3 activity at 9, 12 and 24 hours treatment period, respectively.	Triiodothyronine	10-14	caspase 3	Mus musculus	150-159
16344112-13	2005	Thus, thyroxine deiodinase type II, an enzyme generating triiodothyronine (T(3)) from thyroxine, appears to be exclusively expressed by tanycytes, suggesting that these cells are the main source of brain T(3).	Triiodothyronine	75-79	iodothyronine deiodinase 2	Homo sapiens	6-34
15345678-0	2004	Rapid nongenomic effects of 3,5,3"-triiodo-L-thyronine on the intracellular pH of L-6 myoblasts are mediated by intracellular calcium mobilization and kinase pathways.	Triiodothyronine	28-54	transmembrane 4 L six family member 1	Homo sapiens	82-85
15727804-11	2005	We have also found that mutations in MCT8 are associated with severe X-linked psychomotor retardation and strongly elevated serum T(3) levels in young boys.	Triiodothyronine	130-134	solute carrier family 16 member 2	Homo sapiens	37-41
15589343-0	2004	Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.	Triiodothyronine	11-27	5-hydroxytryptamine receptor 1A	Rattus norvegicus	46-63
15589343-5	2004	The combination of fluoxetine and T3 induced desensitization of 5-HT1B autoreceptors in hypothalamus.	Triiodothyronine	34-36	5-hydroxytryptamine receptor 1B	Rattus norvegicus	64-70
15601836-4	2005	TRbeta(PV/PV) mice lost the negative feedback regulation with highly elevated TSH levels associated with increased thyroid hormone levels (3,3",5-triiodo-l-thyronine [T3]).	Triiodothyronine	139-165	apoptosis antagonizing transcription factor	Mus musculus	0-6
15601836-4	2005	TRbeta(PV/PV) mice lost the negative feedback regulation with highly elevated TSH levels associated with increased thyroid hormone levels (3,3",5-triiodo-l-thyronine [T3]).	Triiodothyronine	167-169	apoptosis antagonizing transcription factor	Mus musculus	0-6
15533828-1	2004	Using PCR cloning, the mRNA of XNkx-2.3 gene, a Xenopus tinman homologue, was identified in a cDNA library prepared from thyroid hormone (T(3))-treated tadpole skin.	Triiodothyronine	138-143	NK2 homeobox 3 S homeolog	Xenopus laevis	31-39
15533828-7	2004	Finally, the T(3)-induced appearance of XNkx-2.3 in head skin occurred earlier and at higher level than that in tail skin.	Triiodothyronine	13-17	NK2 homeobox 3 S homeolog	Xenopus laevis	40-48
15505338-1	2004	We investigated the effects of 5alpha-dihydrotestosterone (DHT), 3,5,3"-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody and immunogold antibody methods for light and electron microscopy.	Triiodothyronine	65-91	keratin 1	Mus musculus	145-148
15505338-1	2004	We investigated the effects of 5alpha-dihydrotestosterone (DHT), 3,5,3"-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody and immunogold antibody methods for light and electron microscopy.	Triiodothyronine	93-97	keratin 1	Mus musculus	145-148
15531715-6	2004	We analyzed the mammary gland during pregnancy and lactation for: (a) the type and amount of thyroid receptors (TRs), (b) the local triiodothyronine (T3) generation catalyzed by type I deiodinase (Dio1), (c) the Dio1 response to norepinephrine (NE) and (d) the effect on Dio1 and TRs of blocking the PRL pulse at peripartum.	Triiodothyronine	132-148	iodothyronine deiodinase 1	Homo sapiens	197-201
15505338-4	2004	Both DHT alone and T(3) alone moderately inhibited mK1 synthesis by increasing the number of mK1-immunonegative GCT cells in Hypox males, but Dex alone had no inhibitory effect on mK1 synthesis.	Triiodothyronine	19-23	keratin 1	Mus musculus	51-54
15531715-6	2004	We analyzed the mammary gland during pregnancy and lactation for: (a) the type and amount of thyroid receptors (TRs), (b) the local triiodothyronine (T3) generation catalyzed by type I deiodinase (Dio1), (c) the Dio1 response to norepinephrine (NE) and (d) the effect on Dio1 and TRs of blocking the PRL pulse at peripartum.	Triiodothyronine	150-152	iodothyronine deiodinase 1	Homo sapiens	197-201
15505338-4	2004	Both DHT alone and T(3) alone moderately inhibited mK1 synthesis by increasing the number of mK1-immunonegative GCT cells in Hypox males, but Dex alone had no inhibitory effect on mK1 synthesis.	Triiodothyronine	19-23	keratin 1	Mus musculus	93-96
15531715-6	2004	We analyzed the mammary gland during pregnancy and lactation for: (a) the type and amount of thyroid receptors (TRs), (b) the local triiodothyronine (T3) generation catalyzed by type I deiodinase (Dio1), (c) the Dio1 response to norepinephrine (NE) and (d) the effect on Dio1 and TRs of blocking the PRL pulse at peripartum.	Triiodothyronine	150-152	iodothyronine deiodinase 1	Homo sapiens	212-216
15531715-6	2004	We analyzed the mammary gland during pregnancy and lactation for: (a) the type and amount of thyroid receptors (TRs), (b) the local triiodothyronine (T3) generation catalyzed by type I deiodinase (Dio1), (c) the Dio1 response to norepinephrine (NE) and (d) the effect on Dio1 and TRs of blocking the PRL pulse at peripartum.	Triiodothyronine	150-152	iodothyronine deiodinase 1	Homo sapiens	212-216
15505338-4	2004	Both DHT alone and T(3) alone moderately inhibited mK1 synthesis by increasing the number of mK1-immunonegative GCT cells in Hypox males, but Dex alone had no inhibitory effect on mK1 synthesis.	Triiodothyronine	19-23	keratin 1	Mus musculus	93-96
15505338-7	2004	These findings suggested that the sexual dimorphism of mK1 expression and the morphological appearance of GCT cells can be induced by treatment with two hormones, DHT and T(3), but not by either of them alone.	Triiodothyronine	171-175	keratin 1	Mus musculus	55-58
15514252-0	2004	Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats.	Triiodothyronine	0-16	glycine N-methyltransferase	Rattus norvegicus	63-90
15523592-0	2004	3,5-diiodothyronine mimics the effect of triiodothyronine on insulin-like growth factor binding protein-4 expression in cultured rat hepatocytes.	Triiodothyronine	41-57	insulin-like growth factor binding protein 4	Rattus norvegicus	61-105
15488219-2	2004	We tested whether mutations in MCT8 cause severe psychomotor retardation and high serum triiodothyronine (T3) concentrations in five unrelated young boys.	Triiodothyronine	88-104	solute carrier family 16 member 2	Homo sapiens	31-35
15488219-2	2004	We tested whether mutations in MCT8 cause severe psychomotor retardation and high serum triiodothyronine (T3) concentrations in five unrelated young boys.	Triiodothyronine	106-108	solute carrier family 16 member 2	Homo sapiens	31-35
15523592-1	2004	We have previously demonstrated that triiodothyronine (T(3)) stimulates hepatic IGFBP-4 expression in rats.	Triiodothyronine	37-53	insulin-like growth factor binding protein 4	Rattus norvegicus	80-87
15523592-1	2004	We have previously demonstrated that triiodothyronine (T(3)) stimulates hepatic IGFBP-4 expression in rats.	Triiodothyronine	55-59	insulin-like growth factor binding protein 4	Rattus norvegicus	80-87
15281085-11	2004	Antisense oligodeoxynucleotides (as-ODN) complementary to c-Fos mRNA at 1 microM significantly inhibited T(3)-induced osteoclast-like cell formation from osteoclast precursors in the absence of stromal cells while sense-ODN did not affect T(3)-induced osteoclast-like cell formation.	Triiodothyronine	105-109	FBJ osteosarcoma oncogene	Mus musculus	58-63
15281085-11	2004	Antisense oligodeoxynucleotides (as-ODN) complementary to c-Fos mRNA at 1 microM significantly inhibited T(3)-induced osteoclast-like cell formation from osteoclast precursors in the absence of stromal cells while sense-ODN did not affect T(3)-induced osteoclast-like cell formation.	Triiodothyronine	239-243	FBJ osteosarcoma oncogene	Mus musculus	58-63
15282446-2	2004	Triiodothyronine, (T(3)), the physiologically active form of thyroid hormone, binds to nuclear receptor proteins and mediates the expression of several important cardiac genes, inducing transcription of the positively regulated genes including alpha-myosin heavy chain (MHC) and the sarcoplasmic reticulum calcium ATPase.	Triiodothyronine	0-16	major histocompatibility complex, class I, C	Homo sapiens	244-268
15472228-8	2004	Immunocytochemical and Western immunoblot analyses revealed that treatment with T(3) increased the expression of MMP-2 and MMP-3 in subsequent 48-h cultured EVTs compared with those in control cultures.	Triiodothyronine	80-84	matrix metallopeptidase 2	Homo sapiens	113-118
15472228-8	2004	Immunocytochemical and Western immunoblot analyses revealed that treatment with T(3) increased the expression of MMP-2 and MMP-3 in subsequent 48-h cultured EVTs compared with those in control cultures.	Triiodothyronine	80-84	matrix metallopeptidase 3	Homo sapiens	123-128
15542352-15	2004	Decreased serum total T(3), T(4), testosterone, estradiol and increased TSH were observed in PCB-exposed rats.	Triiodothyronine	22-26	pyruvate carboxylase	Rattus norvegicus	93-96
15342807-8	2004	Recombinant leptin significantly increased levels of free triiodothyronine, free thyroxine, insulin-like growth factor 1, insulin-like growth factor-binding protein 3, bone alkaline phosphatase, and osteocalcin but not cortisol, corticotropin, or urinary N-telopeptide.	Triiodothyronine	58-74	leptin	Homo sapiens	12-18
15219641-6	2004	T3 at 20 microg/kg s.c. given daily for 1 week also reduced the sensitivity of postsynaptic 5-HT(1A) receptors in the hypothalamus, as measured by injection of 8-OH-DPAT and determination of the plasma ACTH and corticosterone responses.	Triiodothyronine	0-2	5-hydroxytryptamine receptor 1A	Rattus norvegicus	92-99
15700765-7	2004	The PTU-related decrease in expression of RAR, RXR and RC3 was restored following RA or T3 administration, as observed in aged mice.	Triiodothyronine	88-90	retinoic acid receptor, alpha	Mus musculus	42-45
15700765-7	2004	The PTU-related decrease in expression of RAR, RXR and RC3 was restored following RA or T3 administration, as observed in aged mice.	Triiodothyronine	88-90	neurogranin	Mus musculus	55-58
15282446-2	2004	Triiodothyronine, (T(3)), the physiologically active form of thyroid hormone, binds to nuclear receptor proteins and mediates the expression of several important cardiac genes, inducing transcription of the positively regulated genes including alpha-myosin heavy chain (MHC) and the sarcoplasmic reticulum calcium ATPase.	Triiodothyronine	0-16	major histocompatibility complex, class I, C	Homo sapiens	270-273
15282446-2	2004	Triiodothyronine, (T(3)), the physiologically active form of thyroid hormone, binds to nuclear receptor proteins and mediates the expression of several important cardiac genes, inducing transcription of the positively regulated genes including alpha-myosin heavy chain (MHC) and the sarcoplasmic reticulum calcium ATPase.	Triiodothyronine	19-23	major histocompatibility complex, class I, C	Homo sapiens	244-268
15282446-2	2004	Triiodothyronine, (T(3)), the physiologically active form of thyroid hormone, binds to nuclear receptor proteins and mediates the expression of several important cardiac genes, inducing transcription of the positively regulated genes including alpha-myosin heavy chain (MHC) and the sarcoplasmic reticulum calcium ATPase.	Triiodothyronine	19-23	major histocompatibility complex, class I, C	Homo sapiens	270-273
15242747-3	2004	In vivo cortisol and triiodothyronine (T(3)) treatment of seabass larvae upregulated alpha-amylase gene expression.	Triiodothyronine	21-37	pancreatic alpha-amylase-like	Lates calcarifer	85-98
15087435-2	2004	T(4) has to be converted to T(3) for efficient binding to thyroid hormone receptors.	Triiodothyronine	28-32	parathyroid hormone	Gallus gallus	58-73
15242747-3	2004	In vivo cortisol and triiodothyronine (T(3)) treatment of seabass larvae upregulated alpha-amylase gene expression.	Triiodothyronine	39-43	pancreatic alpha-amylase-like	Lates calcarifer	85-98
15292350-0	2004	3,5,3"-Triiodothyronine down-regulates Fas and Fas ligand expression and suppresses caspase-3 and poly (adenosine 5"-diphosphate-ribose) polymerase cleavage and apoptosis in early placental extravillous trophoblasts in vitro.	Triiodothyronine	0-23	caspase 3	Homo sapiens	84-93
15292350-8	2004	Treatment with T(3) reduced the expression of Fas and Fas ligand as well as cleavage of caspase-3 and PARP and suppressed apoptosis in cultured EVTs.	Triiodothyronine	15-19	Fas ligand	Homo sapiens	54-64
15292350-0	2004	3,5,3"-Triiodothyronine down-regulates Fas and Fas ligand expression and suppresses caspase-3 and poly (adenosine 5"-diphosphate-ribose) polymerase cleavage and apoptosis in early placental extravillous trophoblasts in vitro.	Triiodothyronine	0-23	Fas ligand	Homo sapiens	47-57
15292350-8	2004	Treatment with T(3) reduced the expression of Fas and Fas ligand as well as cleavage of caspase-3 and PARP and suppressed apoptosis in cultured EVTs.	Triiodothyronine	15-19	caspase 3	Homo sapiens	88-97
15292350-8	2004	Treatment with T(3) reduced the expression of Fas and Fas ligand as well as cleavage of caspase-3 and PARP and suppressed apoptosis in cultured EVTs.	Triiodothyronine	15-19	poly(ADP-ribose) polymerase 1	Homo sapiens	102-106
15131262-6	2004	The histones H3 and H4 at the TRH promoter were acetylated, and addition of T3 caused recruitment of HDACs 2 and 3 within 15 min, resulting in a transient deacetylation of the histone tails.	Triiodothyronine	76-78	thyrotropin releasing hormone	Homo sapiens	30-33
15291740-2	2004	We previously reported that changes in thyroid status altered anterior pituitary PC1 mRNA and this regulation was due to triiodothyronine (T(3))-dependent interaction of thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large region of the human PC1 promoter.	Triiodothyronine	121-137	proprotein convertase subtilisin/kexin type 1	Homo sapiens	81-84
15291740-2	2004	We previously reported that changes in thyroid status altered anterior pituitary PC1 mRNA and this regulation was due to triiodothyronine (T(3))-dependent interaction of thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large region of the human PC1 promoter.	Triiodothyronine	121-137	proprotein convertase subtilisin/kexin type 1	Homo sapiens	297-300
15291740-2	2004	We previously reported that changes in thyroid status altered anterior pituitary PC1 mRNA and this regulation was due to triiodothyronine (T(3))-dependent interaction of thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large region of the human PC1 promoter.	Triiodothyronine	139-144	proprotein convertase subtilisin/kexin type 1	Homo sapiens	81-84
15291740-2	2004	We previously reported that changes in thyroid status altered anterior pituitary PC1 mRNA and this regulation was due to triiodothyronine (T(3))-dependent interaction of thyroid hormone receptor (TR) with negative thyroid hormone response elements (nTREs) contained in a large region of the human PC1 promoter.	Triiodothyronine	139-144	proprotein convertase subtilisin/kexin type 1	Homo sapiens	297-300
15291742-1	2004	The regulation of expression of type II deiodinase (D2) is a critical mechanism to maintain appropriate intracellular concentrations of tri-iodothyronine in selected tissues.	Triiodothyronine	136-153	iodothyronine deiodinase 2	Homo sapiens	52-54
15193952-5	2004	After a period of 2-10 months of T(3) treatment we observed a significant increase in mRNA levels of the NCX, RyRs and IP(3) receptors.	Triiodothyronine	33-37	solute carrier family 8 member A1	Rattus norvegicus	105-108
15235154-4	2004	Treatment of GH3 rat pituitary tumor cells with DTPA in the presence of T3 resulted in twofold greater concentrations of growth hormone (GH) mRNA.	Triiodothyronine	72-74	gonadotropin releasing hormone receptor	Rattus norvegicus	121-135
15235154-4	2004	Treatment of GH3 rat pituitary tumor cells with DTPA in the presence of T3 resulted in twofold greater concentrations of growth hormone (GH) mRNA.	Triiodothyronine	72-74	gonadotropin releasing hormone receptor	Rattus norvegicus	13-15
15264037-3	2004	In the present study we have addressed the possible interaction between a hypercaloric diet and thyroid hormone (T3), which are strong stimulators of UCP3 gene expression in skeletal muscle.	Triiodothyronine	113-115	uncoupling protein 3	Rattus norvegicus	150-154
15082720-3	2004	Human and piscine TTR bind both thyroid hormones 3,5,3"-triiodo-l-thyronine (T(3)) and 3,5,3",5"-tetraiodo-l-thyronine (thyroxine, T(4)).	Triiodothyronine	49-75	transthyretin	Homo sapiens	18-21
15240372-1	2004	Type I iodothyronine deiodinase (5"-DI) generates the thyromimetically active hormone 3,5,3"-triiodothyronine (T(3)) by reductive monodeiodination of the phenolic ring of L-thyroxine (T(4)).	Triiodothyronine	86-109	iodothyronine deiodinase 1	Rattus norvegicus	0-31
15056670-6	2004	The most potent natural thyroid hormone, 3,5,3"-triidothyronine or T3, shows similar binding affinity and transactivation dose-response curves for both thyroid hormone receptor isotypes, designated TRalpha and TRbeta.	Triiodothyronine	67-69	T cell receptor alpha locus L homeolog	Xenopus laevis	198-205
15056670-6	2004	The most potent natural thyroid hormone, 3,5,3"-triidothyronine or T3, shows similar binding affinity and transactivation dose-response curves for both thyroid hormone receptor isotypes, designated TRalpha and TRbeta.	Triiodothyronine	67-69	thyroid hormone receptor, beta S homeolog	Xenopus laevis	210-216
14970006-9	2004	These changes in COX I closely paralleled the T(3)-induced increases in COX activity observed in both of these tissues.	Triiodothyronine	46-50	cytochrome c oxidase subunit 8A	Homo sapiens	17-20
14970006-9	2004	These changes in COX I closely paralleled the T(3)-induced increases in COX activity observed in both of these tissues.	Triiodothyronine	46-50	cytochrome c oxidase subunit 8A	Homo sapiens	72-75
14970006-10	2004	In liver, T(3) induced a coordinated increase in the expression of the nuclear (COX Vb) and mitochondrial (COX I) genomes at the protein level.	Triiodothyronine	10-14	cytochrome c oxidase subunit 8A	Homo sapiens	80-83
14970006-10	2004	In liver, T(3) induced a coordinated increase in the expression of the nuclear (COX Vb) and mitochondrial (COX I) genomes at the protein level.	Triiodothyronine	10-14	cytochrome c oxidase subunit 8A	Homo sapiens	107-110
14977860-3	2004	The effect of T(3) treatment on target gene regulation was investigated in a TRalpha-overexpressing hepatoma cell line (HepG2-TRalpha), by performing cDNA microarrays.	Triiodothyronine	14-18	T cell receptor alpha locus	Homo sapiens	77-84
14977860-3	2004	The effect of T(3) treatment on target gene regulation was investigated in a TRalpha-overexpressing hepatoma cell line (HepG2-TRalpha), by performing cDNA microarrays.	Triiodothyronine	14-18	T cell receptor alpha locus	Homo sapiens	126-133
15146179-3	2004	In target tissues, T(4) is enzymatically deiodinated to 3,5,3"-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alpha and TR beta, whose activation controls normal vertebrate development and physiology.	Triiodothyronine	56-79	T cell receptor alpha locus	Homo sapiens	140-148
15571324-0	2004	Enhanced connexin-43 and alpha-sarcomeric actin expression in cultured heart myocytes exposed to triiodo-L-thyronine.	Triiodothyronine	97-116	gap junction protein, alpha 1	Rattus norvegicus	9-20
15571324-1	2004	This study examined whether triiodo-L-thyronine (T3) affects the expression of the major intercellular channel protein, connexin-43, and contractile protein alpha-sarcomeric actin.	Triiodothyronine	28-47	gap junction protein, alpha 1	Rattus norvegicus	120-131
15571324-1	2004	This study examined whether triiodo-L-thyronine (T3) affects the expression of the major intercellular channel protein, connexin-43, and contractile protein alpha-sarcomeric actin.	Triiodothyronine	49-51	gap junction protein, alpha 1	Rattus norvegicus	120-131
15169966-4	2004	The early postnatal rise in the lung UCP-2 mRNA concentration was partially blocked by an antithyroid drug and was increased by treatment with triiodothyronine.	Triiodothyronine	143-159	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	37-42
15146179-3	2004	In target tissues, T(4) is enzymatically deiodinated to 3,5,3"-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alpha and TR beta, whose activation controls normal vertebrate development and physiology.	Triiodothyronine	56-79	T cell receptor beta locus	Homo sapiens	153-160
15146179-3	2004	In target tissues, T(4) is enzymatically deiodinated to 3,5,3"-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alpha and TR beta, whose activation controls normal vertebrate development and physiology.	Triiodothyronine	81-85	T cell receptor alpha locus	Homo sapiens	140-148
15146179-3	2004	In target tissues, T(4) is enzymatically deiodinated to 3,5,3"-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alpha and TR beta, whose activation controls normal vertebrate development and physiology.	Triiodothyronine	81-85	T cell receptor beta locus	Homo sapiens	153-160
15072699-1	2004	Thyroid hormones (triiodothyronine [T3] and thyroxine [T4]) stimulate UCP-3 expression in skeletal muscle.	Triiodothyronine	18-34	uncoupling protein 3	Rattus norvegicus	70-75
15004031-7	2004	However, triiodothyronine and T(4) levels in fasted Car(-/-) mice remained significantly higher than those in fasted wild-type animals.	Triiodothyronine	9-25	nuclear receptor subfamily 1, group I, member 3	Mus musculus	52-55
15255076-0	2004	Triiodothyronine (T3) and 1,25-dihydroxyvitamin D3 (1,25D3) inversely regulate OPG gene expression in dependence of the osteoblastic phenotype.	Triiodothyronine	0-16	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	79-82
15255076-0	2004	Triiodothyronine (T3) and 1,25-dihydroxyvitamin D3 (1,25D3) inversely regulate OPG gene expression in dependence of the osteoblastic phenotype.	Triiodothyronine	18-20	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	79-82
15060155-7	2004	To investigate the potential role for TBLR1 complexes during vertebrate development, we made use of T(3)-dependent amphibian metamorphosis as a model.	Triiodothyronine	100-104	TBL1X/Y related 1	Homo sapiens	38-43
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	54-58	TBL1X/Y related 1	Homo sapiens	14-19
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	54-58	nuclear receptor corepressor 2	Homo sapiens	21-25
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	54-58	nuclear receptor corepressor 1	Homo sapiens	31-36
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	128-132	TBL1X/Y related 1	Homo sapiens	14-19
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	128-132	nuclear receptor corepressor 2	Homo sapiens	21-25
15060155-8	2004	We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis.	Triiodothyronine	128-132	nuclear receptor corepressor 1	Homo sapiens	31-36
14993604-9	2004	Human OATP4C1 transports cardiac glycosides (digoxin, K(m) = 7.8 microM and ouabain, K(m) = 0.38 microM), thyroid hormone (triiodothyronine, K(m) = 5.9 microM and thyroxine), cAMP, and methotrexate in a sodium-independent manner.	Triiodothyronine	123-139	solute carrier organic anion transporter family member 4C1	Homo sapiens	6-13
14993604-10	2004	Rat Oatp4c1 also transports digoxin (K(m) = 8.0 microM) and triiodothyronine (K(m) = 1.9 microM).	Triiodothyronine	60-76	solute carrier organic anion transporter family, member 4C1	Rattus norvegicus	4-11
14988240-1	2004	The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3",5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal.	Triiodothyronine	107-109	deiodinase, iodothyronine, type II	Mus musculus	4-8
14988240-1	2004	The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3",5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal.	Triiodothyronine	107-109	deiodinase, iodothyronine, type II	Mus musculus	137-141
14988240-1	2004	The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3",5-triiodothyronine (T3), the disruption of which (Dio2(-/-)) results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal.	Triiodothyronine	107-109	WD and tetratricopeptide repeats 1	Mus musculus	165-172
15156407-5	2004	We found a seven- and three-fold increase of GPDH activity in female rats after T (3) or T (4) administration, respectively, compared to euthyroid females (8.9 +/- 2.3 nmol/min/mg protein), whereas administration of methimazole reduced the enzyme activity almost to one-third of the euthyroid values.	Triiodothyronine	80-85	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	45-49
14726436-3	2004	It was found that expression of Dio2 in the mediobasal hypothalamus is induced by light and that T(3) content in the mediobasal hypothalamus increased under long day conditions.	Triiodothyronine	97-101	type II iodothyronine deiodinase	Coturnix japonica	32-36
15072568-7	2004	We demonstrated that: (1)l -3,5,3"-triiodothyronine (T3) induces mRNA expression of ERalpha; (2) T3 alone is able to induce ERE-luc activity and this is inhibited by OH-tamoxifen; (3) T3 synergistically acts on estradiol (E2)-induced ERE responses; and (4) ERE-luc activity is enchanted by co-transfection of an ERalpha expression vector.	Triiodothyronine	25-51	estrogen receptor 1	Rattus norvegicus	84-91
15072568-7	2004	We demonstrated that: (1)l -3,5,3"-triiodothyronine (T3) induces mRNA expression of ERalpha; (2) T3 alone is able to induce ERE-luc activity and this is inhibited by OH-tamoxifen; (3) T3 synergistically acts on estradiol (E2)-induced ERE responses; and (4) ERE-luc activity is enchanted by co-transfection of an ERalpha expression vector.	Triiodothyronine	25-51	estrogen receptor 1	Rattus norvegicus	312-319
15072568-7	2004	We demonstrated that: (1)l -3,5,3"-triiodothyronine (T3) induces mRNA expression of ERalpha; (2) T3 alone is able to induce ERE-luc activity and this is inhibited by OH-tamoxifen; (3) T3 synergistically acts on estradiol (E2)-induced ERE responses; and (4) ERE-luc activity is enchanted by co-transfection of an ERalpha expression vector.	Triiodothyronine	53-55	estrogen receptor 1	Rattus norvegicus	84-91
15072568-7	2004	We demonstrated that: (1)l -3,5,3"-triiodothyronine (T3) induces mRNA expression of ERalpha; (2) T3 alone is able to induce ERE-luc activity and this is inhibited by OH-tamoxifen; (3) T3 synergistically acts on estradiol (E2)-induced ERE responses; and (4) ERE-luc activity is enchanted by co-transfection of an ERalpha expression vector.	Triiodothyronine	53-55	estrogen receptor 1	Rattus norvegicus	312-319
15072570-11	2004	TRbeta mRNA level increased in the brain, intestine and tail during metamorphosis and was induced by treatment with T(3).	Triiodothyronine	116-120	thyroid hormone receptor, beta S homeolog	Xenopus laevis	0-6
15072699-1	2004	Thyroid hormones (triiodothyronine [T3] and thyroxine [T4]) stimulate UCP-3 expression in skeletal muscle.	Triiodothyronine	36-38	uncoupling protein 3	Rattus norvegicus	70-75
14729480-2	2004	The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3"-triiodothyronine (T3) in peripheral tissues.	Triiodothyronine	95-118	deiodinase, iodothyronine, type 2 L homeolog	Xenopus laevis	11-43
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	227-244	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	12-24
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	227-244	endothelin 1	Mus musculus	114-118
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	246-248	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	12-24
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	246-248	endothelin 1	Mus musculus	114-118
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	30-46	mitogen-activated protein kinase 3	Mus musculus	64-67
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	30-46	cyclin-dependent kinase 20	Mus musculus	68-71
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-53	mitogen-activated protein kinase 3	Mus musculus	64-67
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-53	cyclin-dependent kinase 20	Mus musculus	68-71
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-52	mitogen-activated protein kinase 3	Mus musculus	64-67
15062557-2	2004	We have previously shown that triiodothyronine (T(3)) activates p44/p42 mitogen-activated protein (MAP) kinase, which limits T(3)-induced alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	48-52	cyclin-dependent kinase 20	Mus musculus	68-71
15062557-6	2004	On the contrary, the T(3)-induced osteocalcin synthesis was significantly reduced by SB203580 and PD169316, inhibitors of p38 MAP kinase.	Triiodothyronine	21-25	bone gamma-carboxyglutamate protein 2	Mus musculus	34-45
15062557-6	2004	On the contrary, the T(3)-induced osteocalcin synthesis was significantly reduced by SB203580 and PD169316, inhibitors of p38 MAP kinase.	Triiodothyronine	21-25	mitogen-activated protein kinase 14	Mus musculus	122-125
15062557-7	2004	SB203580, PD169316 or PD98059 suppressed the T(3)-phosphorylation of myelin basic protein.	Triiodothyronine	45-49	myelin basic protein	Mus musculus	69-89
15062557-8	2004	T(3)-induced osteocalcin synthesis was significantly reduced by SB203580 or PD169316 also in primary cultured mouse osteoblasts.	Triiodothyronine	0-4	bone gamma-carboxyglutamate protein 2	Mus musculus	13-24
14729480-2	2004	The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3"-triiodothyronine (T3) in peripheral tissues.	Triiodothyronine	120-122	deiodinase, iodothyronine, type 2 L homeolog	Xenopus laevis	11-43
14759511-6	2004	The positive effect of GH on AdipoR2 expression could be reversed by withdrawal of the hormone for 24 h. In contrast, other key hormones involved in the regulation of insulin resistance and energy metabolism such as insulin, isoproterenol, dexamethasone, triiodothyronine, angiotensin 2, tumor necrosis factor alpha, and interleukin-6 did not influence AdipoR1 and AdipoR2 synthesis in vitro.	Triiodothyronine	255-271	insulin	Homo sapiens	167-174
14592954-4	2004	Accordingly, we hypothesized that T(3) would negatively regulate human CYP7A1 gene expression in vivo.	Triiodothyronine	34-38	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	71-77
14970304-5	2004	When raised total thyroxine and triiodothyronine levels persisted postoperatively, the diagnosis of TBG excess was confirmed.	Triiodothyronine	32-48	serpin family A member 7	Homo sapiens	100-103
14688445-0	2003	Hypothalamic neuropeptide Y/Y1 receptor pathway activated by a reduction in circulating leptin, but not by an increase in circulating ghrelin, contributes to hyperphagia associated with triiodothyronine-induced thyrotoxicosis.	Triiodothyronine	186-202	neuropeptide Y	Rattus norvegicus	13-27
15481810-7	2004	Through tanycyte-cerebrospinal fluid, -vascular or -neuronal associations, these cells may lead to inhibition of TRH gene expression in hypophysiotropic neurons by increasing local triiodothyronine production.	Triiodothyronine	181-197	thyrotropin releasing hormone	Homo sapiens	113-116
15299990-7	2004	After growth hormone treatment serum concentration of Insulin like growth factor -1 (IGF-1) and triiodothyronine increased and concentration of serum free thyroxine decreased significantly in comparison to basal concentration.	Triiodothyronine	96-112	growth hormone 1	Homo sapiens	6-20
15209538-3	2004	It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II.	Triiodothyronine	18-34	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	45-50
15209538-4	2004	Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production.	Triiodothyronine	55-71	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	29-34
12959642-3	2003	In co-transfection experiments of HEK-293 (human embryonic kidney 293) cells, the -911/+29 human apoA-II promoter was transactivated strongly by RXRalpha/T(3)Rbeta heterodimers in the presence of RA (9- cis retinoic acid) or T(3) (tri-iodothyronine).	Triiodothyronine	154-158	apolipoprotein A2	Homo sapiens	97-104
12959642-3	2003	In co-transfection experiments of HEK-293 (human embryonic kidney 293) cells, the -911/+29 human apoA-II promoter was transactivated strongly by RXRalpha/T(3)Rbeta heterodimers in the presence of RA (9- cis retinoic acid) or T(3) (tri-iodothyronine).	Triiodothyronine	154-158	retinoid X receptor alpha	Homo sapiens	145-153
14675715-6	2003	Cells cotransfected with KLF4 and TR beta 1 in the presence of T3 showed synergistic activation (70-fold).	Triiodothyronine	63-65	Kruppel like factor 4	Homo sapiens	25-29
14557374-3	2003	Several potent heteroactivators of CYP2C9-mediated 7-methoxy-4-trifluoromethyl-coumarin metabolism are marketed drugs or endogenous compounds (amiodarone, niclosamide, liothyronine, meclofenemate, zafirlukast, estropipate, and dichlorphenamide, yielding 150% control reaction velocity at 0.04, 0.09, 0.5, 1, 1.2, 1.5, and 2.5 microM, respectively).	Triiodothyronine	168-180	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	35-41
14759511-6	2004	The positive effect of GH on AdipoR2 expression could be reversed by withdrawal of the hormone for 24 h. In contrast, other key hormones involved in the regulation of insulin resistance and energy metabolism such as insulin, isoproterenol, dexamethasone, triiodothyronine, angiotensin 2, tumor necrosis factor alpha, and interleukin-6 did not influence AdipoR1 and AdipoR2 synthesis in vitro.	Triiodothyronine	255-271	growth hormone 1	Homo sapiens	23-25
14758565-8	2004	It has now been shown to influence the abundance of UCP1 in the fetus, a role that may in part be regulated by the metabolically active thyroid hormone triiodothyronine.	Triiodothyronine	152-168	uncoupling protein 1	Homo sapiens	52-56
15240998-3	2004	Triiodothyronine (T(3), 10 nM) transiently but significantly stimulated the promoter activity of GH gene, whereas retinoic acids (9-cis and all-trans, both 1 microM) showed sustained stimulation.	Triiodothyronine	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
15240998-3	2004	Triiodothyronine (T(3), 10 nM) transiently but significantly stimulated the promoter activity of GH gene, whereas retinoic acids (9-cis and all-trans, both 1 microM) showed sustained stimulation.	Triiodothyronine	18-22	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
15240998-5	2004	Synthetic glucocorticoid hormone dexamethasone (100 nM) showed an inhibitory effect but, interestingly, significantly enhanced T(3)-stimulated GH promoter activity during long-term incubation.	Triiodothyronine	127-131	gonadotropin releasing hormone receptor	Rattus norvegicus	143-145
14656206-6	2003	Immunoblot and Northern blot analyses revealed that exposure of HepG2-TRalpha1 sub-lines and HepG2-Neo cells to tri-iodothyronine (T(3)) induced time- and dose-dependent increases in the abundance of transferrin mRNA and protein, with the extent of these effects correlating with the level of expression of TRalpha1.	Triiodothyronine	112-129	transferrin	Homo sapiens	200-211
14656206-6	2003	Immunoblot and Northern blot analyses revealed that exposure of HepG2-TRalpha1 sub-lines and HepG2-Neo cells to tri-iodothyronine (T(3)) induced time- and dose-dependent increases in the abundance of transferrin mRNA and protein, with the extent of these effects correlating with the level of expression of TRalpha1.	Triiodothyronine	131-135	transferrin	Homo sapiens	200-211
14688445-0	2003	Hypothalamic neuropeptide Y/Y1 receptor pathway activated by a reduction in circulating leptin, but not by an increase in circulating ghrelin, contributes to hyperphagia associated with triiodothyronine-induced thyrotoxicosis.	Triiodothyronine	186-202	leptin	Rattus norvegicus	88-94
14688445-9	2003	Hypothalamic NPY mRNA levels were significantly increased and associated with a marked decreased in both hypothalamic POMC and CART mRNA levels in the T(3)-treated rats.	Triiodothyronine	151-155	neuropeptide Y	Rattus norvegicus	13-16
14688445-9	2003	Hypothalamic NPY mRNA levels were significantly increased and associated with a marked decreased in both hypothalamic POMC and CART mRNA levels in the T(3)-treated rats.	Triiodothyronine	151-155	proopiomelanocortin	Rattus norvegicus	118-122
14688445-9	2003	Hypothalamic NPY mRNA levels were significantly increased and associated with a marked decreased in both hypothalamic POMC and CART mRNA levels in the T(3)-treated rats.	Triiodothyronine	151-155	CART prepropeptide	Rattus norvegicus	127-131
14688445-12	2003	Therefore, the decreased plasma leptin levels could contribute to hyperphagia in T(3)-induced thyrotoxicosis.	Triiodothyronine	81-85	leptin	Rattus norvegicus	32-38
14561585-4	2003	The studies of individual substrates and hormones in a human intestinal cell line (Caco-2) have shown that dipeptides, certain amino acids, insulin, and leptin increase and epidermal growth factor and triiodothyronine decrease the membrane population of Pept-1.	Triiodothyronine	201-217	solute carrier family 15 member 1	Homo sapiens	254-260
14761347-5	2003	The NGF protein expression in rat brain was observed by immunohistochemistry Triiodothyronine (T3), thyroxin (T4), TSH in serum and T3, T4 in brain tissue were determined by radio immunoassays (RIAs).	Triiodothyronine	77-93	nerve growth factor	Rattus norvegicus	4-7
14761347-5	2003	The NGF protein expression in rat brain was observed by immunohistochemistry Triiodothyronine (T3), thyroxin (T4), TSH in serum and T3, T4 in brain tissue were determined by radio immunoassays (RIAs).	Triiodothyronine	95-97	nerve growth factor	Rattus norvegicus	4-7
14614506-4	2003	Here we report that expression in the MBH of the gene encoding type 2 iodothyronine deiodinase (Dio2), which catalyses the intracellular deiodination of thyroxine (T4) prohormone to the active 3,5,3"-triiodothyronine (T3), is induced by light in Japanese quail.	Triiodothyronine	218-220	type II iodothyronine deiodinase	Coturnix japonica	96-100
14596673-0	2003	Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.	Triiodothyronine	0-16	thyroid hormone receptor alpha	Homo sapiens	53-83
14578412-6	2003	In addition, oatp-E function was analyzed in cultured rat RPE cells by measuring the uptake of triiodothyronine (T3), which is a known substrate for oatp-E.	Triiodothyronine	95-111	solute carrier organic anion transporter family, member 4a1	Rattus norvegicus	13-19
14578412-6	2003	In addition, oatp-E function was analyzed in cultured rat RPE cells by measuring the uptake of triiodothyronine (T3), which is a known substrate for oatp-E.	Triiodothyronine	95-111	solute carrier organic anion transporter family, member 4a1	Rattus norvegicus	149-155
14578412-6	2003	In addition, oatp-E function was analyzed in cultured rat RPE cells by measuring the uptake of triiodothyronine (T3), which is a known substrate for oatp-E.	Triiodothyronine	113-115	solute carrier organic anion transporter family, member 4a1	Rattus norvegicus	13-19
14578412-6	2003	In addition, oatp-E function was analyzed in cultured rat RPE cells by measuring the uptake of triiodothyronine (T3), which is a known substrate for oatp-E.	Triiodothyronine	113-115	solute carrier organic anion transporter family, member 4a1	Rattus norvegicus	149-155
12871948-6	2003	MCT8 cRNA induced an approximately 10-fold increase in uptake of 10 nM 125I-labeled thyroxine (T4), 3,3",5-triiodothyronine (T3), 3,3",5"-triiodothyronine (rT3) and 3,3"-diiodothyronine.	Triiodothyronine	125-127	solute carrier family 16 member 2	Rattus norvegicus	0-4
12923172-5	2003	The uptake of triiodothyronine (T3), an active form produced from T4, was significantly greater in Oatp14-expressed cells than in vector-transfected cells, but the transport activity for T3 was approximately 6-fold lower that for T4.	Triiodothyronine	14-30	solute carrier organic anion transporter family, member 1c1	Rattus norvegicus	99-105
12923172-5	2003	The uptake of triiodothyronine (T3), an active form produced from T4, was significantly greater in Oatp14-expressed cells than in vector-transfected cells, but the transport activity for T3 was approximately 6-fold lower that for T4.	Triiodothyronine	32-34	solute carrier organic anion transporter family, member 1c1	Rattus norvegicus	99-105
14514340-6	2003	Both thyroid hormones and leptin might be involved in the adaptive thermogenesis through mitochondrial uncoupling proteins and heat production because both thyroxine and triiodothyronine are involved in the starvation-induced decrease in thermogenesis.	Triiodothyronine	170-186	leptin	Homo sapiens	26-32
12865408-1	2003	The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that activates the pro-hormone thyroxine (T4) and supplies most of the 3,5,3"-triiodothyronine (T3) that is essential for brain development.	Triiodothyronine	186-188	iodothyronine deiodinase 2	Homo sapiens	4-35
12964818-3	2003	In addition to expected correlations among thyroid parameters and substrate-product relationships among the steroids, several new relationships were revealed: The only thyroid parameter tightly correlating with SHBG was free triiodothyronine.	Triiodothyronine	225-241	sex hormone binding globulin	Homo sapiens	211-215
12885587-6	2003	It is concluded that T(3)-induced oxidative stress enhances the DNA-binding activity of NF-kappaB and the NF-kappaB-dependent expression of TNF-alpha and IL-10 genes.	Triiodothyronine	21-25	tumor necrosis factor	Rattus norvegicus	140-149
12885587-6	2003	It is concluded that T(3)-induced oxidative stress enhances the DNA-binding activity of NF-kappaB and the NF-kappaB-dependent expression of TNF-alpha and IL-10 genes.	Triiodothyronine	21-25	interleukin 10	Rattus norvegicus	154-159
14558918-8	2003	After adjustment for age, the only significant positive correlation was between SHBG and free triiodothyronine.	Triiodothyronine	94-110	sex hormone binding globulin	Homo sapiens	80-84
12844391-0	2003	Triiodothyronine administration reverses vitamin A deficiency-related hypo-expression of retinoic acid and triiodothyronine nuclear receptors and of neurogranin in rat brain.	Triiodothyronine	0-16	neurogranin	Rattus norvegicus	149-160
12844391-3	2003	Knowing that RC3 is both a triiodothyronine (T3) and a RA target gene, and in consideration of the relationships between the signalling pathways of retinoids and thyroid hormones, the involvement of T3 on RA signalling functionality in VAD was investigated.	Triiodothyronine	27-43	neurogranin	Rattus norvegicus	13-16
12844391-3	2003	Knowing that RC3 is both a triiodothyronine (T3) and a RA target gene, and in consideration of the relationships between the signalling pathways of retinoids and thyroid hormones, the involvement of T3 on RA signalling functionality in VAD was investigated.	Triiodothyronine	45-47	neurogranin	Rattus norvegicus	13-16
14605990-0	2003	Presence of functional domains in NADPH-dependent cytosolic 3,5,3"-Triiodo-L-thyronine (T3)-binding protein (p38CTBP) molecule: analyses with deletion mutants.	Triiodothyronine	60-86	2,4-dienoyl-CoA reductase 1	Homo sapiens	34-39
14605990-1	2003	Functional domains required for NADPH-binding, T(3)-binding, protein dimerization and cytosolic retention were analyzed in NADPH-dependent cytosolic 3,5,3"-triiodothyronine (T(3))-binding protein (p38CTBP) by using the deletion mutants.	Triiodothyronine	47-51	2,4-dienoyl-CoA reductase 1	Homo sapiens	123-128
14605990-1	2003	Functional domains required for NADPH-binding, T(3)-binding, protein dimerization and cytosolic retention were analyzed in NADPH-dependent cytosolic 3,5,3"-triiodothyronine (T(3))-binding protein (p38CTBP) by using the deletion mutants.	Triiodothyronine	149-172	2,4-dienoyl-CoA reductase 1	Homo sapiens	32-37
14605990-1	2003	Functional domains required for NADPH-binding, T(3)-binding, protein dimerization and cytosolic retention were analyzed in NADPH-dependent cytosolic 3,5,3"-triiodothyronine (T(3))-binding protein (p38CTBP) by using the deletion mutants.	Triiodothyronine	149-172	2,4-dienoyl-CoA reductase 1	Homo sapiens	123-128
14605990-1	2003	Functional domains required for NADPH-binding, T(3)-binding, protein dimerization and cytosolic retention were analyzed in NADPH-dependent cytosolic 3,5,3"-triiodothyronine (T(3))-binding protein (p38CTBP) by using the deletion mutants.	Triiodothyronine	174-179	2,4-dienoyl-CoA reductase 1	Homo sapiens	32-37
14605990-1	2003	Functional domains required for NADPH-binding, T(3)-binding, protein dimerization and cytosolic retention were analyzed in NADPH-dependent cytosolic 3,5,3"-triiodothyronine (T(3))-binding protein (p38CTBP) by using the deletion mutants.	Triiodothyronine	174-179	2,4-dienoyl-CoA reductase 1	Homo sapiens	123-128
14605990-3	2003	NADPH-dependent T(3)-binding activity was not observed in all mutant p38CTBPs studied, although wild-type p38CTBP showed high-affinity T(3)-binding activity.	Triiodothyronine	16-20	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
12933655-5	2003	Both T(4) and T(3) could act synergistically with CORT to increase somatotroph abundance, but the effects of T(3) were biphasic, inhibiting CORT actions at higher concentrations.	Triiodothyronine	109-113	CORT	Gallus gallus	140-144
12933655-7	2003	Furthermore, T(3) treatment overcame the iopanoic acid-induced reduction in the T(4)-CORT effect.	Triiodothyronine	13-17	CORT	Gallus gallus	85-89
12960772-0	2003	Stimulation of AChE activity in relation to changes in electronmicroscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3"-triiodo-L-thyronine.	Triiodothyronine	143-169	acetylcholinesterase	Rattus norvegicus	15-19
12960772-1	2003	Triiodothyronine (T3) stimulated AChE activity in depolarization-induced intact synaptosomes (isolated from adult rat cerebral cortex) suspended in calcium-supplemented choline chloride buffer in a time-dependent manner maximally 45-60 s after T3 administration and in a dose-dependent manner with an optimum at 10-100 nM.	Triiodothyronine	0-16	acetylcholinesterase	Rattus norvegicus	33-37
12960772-1	2003	Triiodothyronine (T3) stimulated AChE activity in depolarization-induced intact synaptosomes (isolated from adult rat cerebral cortex) suspended in calcium-supplemented choline chloride buffer in a time-dependent manner maximally 45-60 s after T3 administration and in a dose-dependent manner with an optimum at 10-100 nM.	Triiodothyronine	18-20	acetylcholinesterase	Rattus norvegicus	33-37
12814968-4	2003	In wild-type mice, PCN treatment significantly increased UGT activities toward bilirubin, 1-naphthol, chloramphenicol, thyroxine, and triiodothyronine.	Triiodothyronine	134-150	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	57-60
12734114-2	2003	The induction of PGC-1alpha protein expression under conditions that provoke mitochondrial biogenesis, such as contractile activity or thyroid hormone (T(3)) treatment, is not fully characterized.	Triiodothyronine	152-157	PPARG coactivator 1 alpha	Homo sapiens	17-27
12609823-1	2003	We developed an RT-PCR assay to study both the time course and the mechanism for the triiodothyronine (T(3))-induced transcription of the alpha- and beta-myosin heavy chain (MHC) genes in vivo on the basis of the quantity of specific heterogeneous nuclear RNA (hnRNA).	Triiodothyronine	85-101	myosin heavy chain 7	Rattus norvegicus	149-172
12609823-1	2003	We developed an RT-PCR assay to study both the time course and the mechanism for the triiodothyronine (T(3))-induced transcription of the alpha- and beta-myosin heavy chain (MHC) genes in vivo on the basis of the quantity of specific heterogeneous nuclear RNA (hnRNA).	Triiodothyronine	85-101	myosin heavy chain 7	Rattus norvegicus	174-177
12609823-1	2003	We developed an RT-PCR assay to study both the time course and the mechanism for the triiodothyronine (T(3))-induced transcription of the alpha- and beta-myosin heavy chain (MHC) genes in vivo on the basis of the quantity of specific heterogeneous nuclear RNA (hnRNA).	Triiodothyronine	103-107	myosin heavy chain 7	Rattus norvegicus	149-172
12609823-1	2003	We developed an RT-PCR assay to study both the time course and the mechanism for the triiodothyronine (T(3))-induced transcription of the alpha- and beta-myosin heavy chain (MHC) genes in vivo on the basis of the quantity of specific heterogeneous nuclear RNA (hnRNA).	Triiodothyronine	103-107	myosin heavy chain 7	Rattus norvegicus	174-177
12609823-3	2003	Quantitation of alpha-MHC hnRNA demonstrated that T(3) induced alpha-MHC transcription in hypothyroid rats within 30 min of a single injection of T(3) (0.5 microg/100 g body wt).	Triiodothyronine	50-54	myosin heavy chain 7	Rattus norvegicus	22-25
12609823-3	2003	Quantitation of alpha-MHC hnRNA demonstrated that T(3) induced alpha-MHC transcription in hypothyroid rats within 30 min of a single injection of T(3) (0.5 microg/100 g body wt).	Triiodothyronine	50-54	myosin heavy chain 7	Rattus norvegicus	69-72
12609823-5	2003	The transcription of beta-MHC was reduced to 86% of peak hypothyroid levels 6 h after a single T(3) injection and reached a nadir of 59% of hypothyroid levels at 36 h. Analysis of the time course of T(3)-mediated induction of alpha-MHC hnRNA and repression of beta-MHC hnRNA indicates that separate molecular mechanisms are involved in the coordinated regulation of these genes.	Triiodothyronine	95-99	myosin heavy chain 7	Rattus norvegicus	26-29
12877347-0	2003	RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult rats.	Triiodothyronine	102-118	phenylalanine hydroxylase	Rattus norvegicus	84-87
12585964-7	2003	The same mutations also abolished transactivation of the HCR-1/apoC-II promoter cluster by RXRalpha-T3Rbeta heterodimers in the presence of tri-iodothyronine.	Triiodothyronine	140-157	apolipoprotein C2	Homo sapiens	63-70
12585964-7	2003	The same mutations also abolished transactivation of the HCR-1/apoC-II promoter cluster by RXRalpha-T3Rbeta heterodimers in the presence of tri-iodothyronine.	Triiodothyronine	140-157	retinoid X receptor alpha	Homo sapiens	91-99
12877347-0	2003	RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult rats.	Triiodothyronine	120-122	phenylalanine hydroxylase	Rattus norvegicus	84-87
12877347-1	2003	Our previous studies have shown that a pre-treatment of rats with triiodothyronine (T3) or dexamethasone (DEXA) increases renal PAH excretion significantly.	Triiodothyronine	66-82	phenylalanine hydroxylase	Rattus norvegicus	128-131
12877347-1	2003	Our previous studies have shown that a pre-treatment of rats with triiodothyronine (T3) or dexamethasone (DEXA) increases renal PAH excretion significantly.	Triiodothyronine	84-86	phenylalanine hydroxylase	Rattus norvegicus	128-131
12877347-11	2003	Semi-quantitative measurements of OAT1 mRNA expression level showed a significant increase of OAT1 mRNA after pre-treatment with both T3 and DEXA in the two age groups.	Triiodothyronine	134-136	solute carrier family 22 member 6	Rattus norvegicus	34-38
12877347-11	2003	Semi-quantitative measurements of OAT1 mRNA expression level showed a significant increase of OAT1 mRNA after pre-treatment with both T3 and DEXA in the two age groups.	Triiodothyronine	134-136	solute carrier family 22 member 6	Rattus norvegicus	94-98
12955882-0	2003	Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line.	Triiodothyronine	0-16	hepatocyte growth factor	Rattus norvegicus	63-66
12855010-0	2003	Paradoxical triiodothyronine suppression of S14 transcription in permanent hepatic cell lines.	Triiodothyronine	12-28	thyroid hormone responsive	Homo sapiens	44-47
12569081-6	2003	Decreased NHE3 and NaPi2 expression was most likely due to a combination of triiodo-l-thyronine (T(3)) deficiency along with a reduced glomerular filtration rate.	Triiodothyronine	76-95	solute carrier family 9 member A3	Rattus norvegicus	10-14
12569081-6	2003	Decreased NHE3 and NaPi2 expression was most likely due to a combination of triiodo-l-thyronine (T(3)) deficiency along with a reduced glomerular filtration rate.	Triiodothyronine	76-95	solute carrier family 34 member 1	Rattus norvegicus	19-24
12569081-6	2003	Decreased NHE3 and NaPi2 expression was most likely due to a combination of triiodo-l-thyronine (T(3)) deficiency along with a reduced glomerular filtration rate.	Triiodothyronine	97-101	solute carrier family 9 member A3	Rattus norvegicus	10-14
12569081-6	2003	Decreased NHE3 and NaPi2 expression was most likely due to a combination of triiodo-l-thyronine (T(3)) deficiency along with a reduced glomerular filtration rate.	Triiodothyronine	97-101	solute carrier family 34 member 1	Rattus norvegicus	19-24
12855010-1	2003	Both in vivo and in primary rat hepatocyte culture, carbohydrate and triiodothyronine (T(3)) rapidly induce transcription of the rat S14 gene.	Triiodothyronine	69-85	thyroid hormone responsive	Rattus norvegicus	133-136
12855010-1	2003	Both in vivo and in primary rat hepatocyte culture, carbohydrate and triiodothyronine (T(3)) rapidly induce transcription of the rat S14 gene.	Triiodothyronine	87-91	thyroid hormone responsive	Rattus norvegicus	133-136
12657491-7	2003	In addition, since the thyroid hormone has been demonstrated to down regulate the mdr gene during Xenopus development and in primary culture of Xenopus intestinal epithelial cells, the effects of 3,3",5-triiodo-L-thyronine (T(3)) on CYP1A and Pgp protein levels have been investigated in adult organisms.	Triiodothyronine	196-222	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	233-238
12562779-0	2003	Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.	Triiodothyronine	0-16	natriuretic peptide B	Rattus norvegicus	27-52
12562779-0	2003	Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.	Triiodothyronine	0-16	natriuretic peptide B	Rattus norvegicus	54-57
12562779-0	2003	Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.	Triiodothyronine	0-16	natriuretic peptide B	Rattus norvegicus	113-116
12562779-4	2003	BNP secretion was increased 6-fold, BNP mRNA levels 3-fold, and BNP promoter activity 3-5-fold following T(3) treatment.	Triiodothyronine	105-109	natriuretic peptide B	Rattus norvegicus	0-3
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Triiodothyronine	102-106	aryl hydrocarbon receptor L homeolog	Xenopus laevis	224-227
12640018-2	2003	Increments in hepatic and renal G6P and PEPCK activities seen between 127-130 and 140-145 days of gestation (term, 145 +/- 2 days) were abolished when the normal prepartum rise in plasma triiodothyronine (T3), but not cortisol, was prevented by fetal thyroidectomy (TX).	Triiodothyronine	187-203	phosphoenolpyruvate carboxykinase, cytosolic [GTP]	Ovis aries	40-45
12640018-2	2003	Increments in hepatic and renal G6P and PEPCK activities seen between 127-130 and 140-145 days of gestation (term, 145 +/- 2 days) were abolished when the normal prepartum rise in plasma triiodothyronine (T3), but not cortisol, was prevented by fetal thyroidectomy (TX).	Triiodothyronine	205-207	phosphoenolpyruvate carboxykinase, cytosolic [GTP]	Ovis aries	40-45
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Triiodothyronine	102-106	cytochrome P450 family 1 subfamily A member 1 L homeolog	Xenopus laevis	37-42
12657491-13	2003	For the first time the modulation of CYP1A and Pgp levels by B(a)P, 3MC and in particular by TCDD and T(3) in Xenopus has been demonstrated and the results herewith indicate that the two target defence mechanisms respond to AHR agonists in a dissimilar way in terms of proteins induction in Xenopus.	Triiodothyronine	102-106	phosphoglycolate phosphatase	Homo sapiens	47-50
12639914-1	2003	We examined the hypothesis that rat fatty acid translocase (rFAT) mediates the cellular uptake of T(3) and other iodothyronines.	Triiodothyronine	98-102	FAT atypical cadherin 1	Rattus norvegicus	60-64
12639914-3	2003	Injection of rFAT cRNA resulted in a 1.9-fold increase in uptake of T(3) (10 nM) and a 1.4-fold increase in uptake of oleic acid (100 micro M).	Triiodothyronine	68-72	FAT atypical cadherin 1	Rattus norvegicus	13-17
12639914-5	2003	The fold induction of T(3) uptake by rFAT was not influenced by BSA.	Triiodothyronine	22-26	FAT atypical cadherin 1	Rattus norvegicus	37-41
12639914-8	2003	The injection of human type III deiodinase cRNA with or without rFAT cRNA resulted in the complete deiodination of T(3) taken up by the oocytes, indicating that T(3) is indeed transported to the cytoplasm.	Triiodothyronine	115-119	FAT atypical cadherin 1	Rattus norvegicus	64-68
12639914-8	2003	The injection of human type III deiodinase cRNA with or without rFAT cRNA resulted in the complete deiodination of T(3) taken up by the oocytes, indicating that T(3) is indeed transported to the cytoplasm.	Triiodothyronine	161-165	FAT atypical cadherin 1	Rattus norvegicus	64-68
12639914-9	2003	In conclusion, our results demonstrate transport of T(3) and other iodothyronines by rFAT.	Triiodothyronine	52-56	FAT atypical cadherin 1	Rattus norvegicus	85-89
12586314-11	2003	Our third objective was to inhibit endogenous TRH with 3,5,3"-triiodothyronine (T(3)) and examine basal, GH-releasing hormone (GHRH)-, TRH- and quipazine-induced secretion of GH.	Triiodothyronine	55-78	thyrotropin releasing hormone	Bos taurus	46-49
12746755-9	2003	Triiodothyronine, at a high concentration (10(-7) M), stimulated GH-receptor (GHR) mRNA levels by 165.20 +/- 16.54 % after 24 h (p < 0.05).	Triiodothyronine	0-16	growth hormone receptor	Homo sapiens	65-76
12746755-9	2003	Triiodothyronine, at a high concentration (10(-7) M), stimulated GH-receptor (GHR) mRNA levels by 165.20 +/- 16.54 % after 24 h (p < 0.05).	Triiodothyronine	0-16	growth hormone receptor	Homo sapiens	78-81
12864947-1	2003	OBJECTIVE: To explore the effect of T(3) on the expression of transferrin receptor (TfR) and ferritin (Fn) in K562 cells and its possible mechanism.	Triiodothyronine	36-40	transferrin receptor	Homo sapiens	62-82
12864947-1	2003	OBJECTIVE: To explore the effect of T(3) on the expression of transferrin receptor (TfR) and ferritin (Fn) in K562 cells and its possible mechanism.	Triiodothyronine	36-40	transferrin receptor	Homo sapiens	84-87
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	53-69	transforming growth factor, beta 1	Mus musculus	84-92
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	53-69	heat shock protein 1	Mus musculus	117-122
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	71-75	transforming growth factor, beta 1	Mus musculus	84-92
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	71-75	heat shock protein 1	Mus musculus	117-122
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	71-75	vascular endothelial growth factor A	Mus musculus	140-174
12706291-2	2003	In the present study, we investigated the effects of triiodothyronine (T(3)) on the TGF-beta-stimulated induction of HSP27 and synthesis of vascular endothelial growth factor (VEGF) in these cells.	Triiodothyronine	71-75	vascular endothelial growth factor A	Mus musculus	176-180
12778365-4	2003	Interestingly, treatment of 3T3-Ll adipocytes with 10 micro M isoproterenol, 10 ng/ml TNFalpha, and 100 nM dexamethasone for 16 h inhibited AQPap gene expression by 62 %, 60 %, and 39 %, respectively; angiotensin 2, growth hormone, and triiodothyronine did not have any effect.	Triiodothyronine	236-252	tumor necrosis factor	Homo sapiens	86-94
12778365-4	2003	Interestingly, treatment of 3T3-Ll adipocytes with 10 micro M isoproterenol, 10 ng/ml TNFalpha, and 100 nM dexamethasone for 16 h inhibited AQPap gene expression by 62 %, 60 %, and 39 %, respectively; angiotensin 2, growth hormone, and triiodothyronine did not have any effect.	Triiodothyronine	236-252	aquaporin 7	Homo sapiens	140-145
12766327-10	2003	doses of TRH used produced changes in T(3) plasma levels, strongly suggesting that the effect on sympathetic activity is mediated by a central effect of TRH acting as a putative activator of ovarian sympathetic nerves.	Triiodothyronine	38-42	thyrotropin releasing hormone	Rattus norvegicus	9-12
12766327-10	2003	doses of TRH used produced changes in T(3) plasma levels, strongly suggesting that the effect on sympathetic activity is mediated by a central effect of TRH acting as a putative activator of ovarian sympathetic nerves.	Triiodothyronine	38-42	thyrotropin releasing hormone	Rattus norvegicus	153-156
12649043-6	2003	Chlorinated derivatives with a greater degree of chlorination were more efficient competitors of T(3) binding to TTR and TR.	Triiodothyronine	97-101	transthyretin	Gallus gallus	113-116
12667197-3	2003	Thyroglobulin (Tg) purified from canine thyroids and the thyroid hormones thyroxine and triiodothyronine (T3 and T4) were conjugated to biotin labelling reagents and attached to the MTP over the SA-biotin bridge.	Triiodothyronine	106-108	thyroglobulin	Canis lupus familiaris	0-13
12649043-10	2003	As some of the chlorinated bisphenols and nonylphenols were potent competitors of T(3) binding to TTRs, the TTR assay could be applied as primary screening for possible thyroid-disrupting chemicals in environmental waste water.	Triiodothyronine	82-86	transthyretin	Gallus gallus	98-101
12538616-0	2003	Dronerarone acts as a selective inhibitor of 3,5,3"-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence.	Triiodothyronine	45-68	thyroid hormone receptor alpha	Homo sapiens	80-111
12538616-6	2003	Debutyldronedarone inhibited T(3) binding to TRalpha(1) by 77%, but to TRbeta(1) by only 25%.	Triiodothyronine	29-33	thyroid hormone receptor alpha	Homo sapiens	45-55
12388124-1	2003	Thyroid hormone [3,5,3"-triiodo-l-thyronine (T(3))] induces phenotypic alterations in cardiac mitochondria, in part by influencing protein import and the expression of the import motor mitochondrial heat shock protein (mtHsp70).	Triiodothyronine	17-43	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	219-226
12576518-1	2003	In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-alpha (ACCalpha) transcription by 3,5,3"-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (-101 to -71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element-binding protein-1 (SREBP-1).	Triiodothyronine	125-127	acetyl-CoA carboxylase alpha	Gallus gallus	43-71
12576518-1	2003	In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-alpha (ACCalpha) transcription by 3,5,3"-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (-101 to -71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element-binding protein-1 (SREBP-1).	Triiodothyronine	125-127	sterol regulatory element binding transcription factor 1	Gallus gallus	234-277
12576518-1	2003	In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-alpha (ACCalpha) transcription by 3,5,3"-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (-101 to -71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element-binding protein-1 (SREBP-1).	Triiodothyronine	125-127	sterol regulatory element binding transcription factor 1	Gallus gallus	279-286
12581883-2	2003	Among the chemicals investigated diethylstilbestrol (DES) was the most powerful inhibitor of [125I]T(3) binding to chicken and bullfrog TTR (cTTR and bTTR).	Triiodothyronine	99-103	transthyretin	Gallus gallus	136-139
12581883-12	2003	Several endocrine disrupting chemicals that were tested interfered with T(3) binding to TTR rather than to TR.	Triiodothyronine	72-76	transthyretin	Gallus gallus	88-91
12580760-2	2003	We have demonstrated that tri-iodothyronine (T3) increased and 1,25-dihydroxyvitamin D3 (1,25D3) attenuated the T3-stimulated expression of osteocalcin (OCN) in the osteoblast-like cell line MC3T3-E1.	Triiodothyronine	26-43	bone gamma-carboxyglutamate protein 2	Mus musculus	140-151
12580760-2	2003	We have demonstrated that tri-iodothyronine (T3) increased and 1,25-dihydroxyvitamin D3 (1,25D3) attenuated the T3-stimulated expression of osteocalcin (OCN) in the osteoblast-like cell line MC3T3-E1.	Triiodothyronine	26-43	bone gamma-carboxyglutamate protein 2	Mus musculus	153-156
12580760-2	2003	We have demonstrated that tri-iodothyronine (T3) increased and 1,25-dihydroxyvitamin D3 (1,25D3) attenuated the T3-stimulated expression of osteocalcin (OCN) in the osteoblast-like cell line MC3T3-E1.	Triiodothyronine	45-47	bone gamma-carboxyglutamate protein 2	Mus musculus	140-151
12580760-2	2003	We have demonstrated that tri-iodothyronine (T3) increased and 1,25-dihydroxyvitamin D3 (1,25D3) attenuated the T3-stimulated expression of osteocalcin (OCN) in the osteoblast-like cell line MC3T3-E1.	Triiodothyronine	45-47	bone gamma-carboxyglutamate protein 2	Mus musculus	153-156
12388124-1	2003	Thyroid hormone [3,5,3"-triiodo-l-thyronine (T(3))] induces phenotypic alterations in cardiac mitochondria, in part by influencing protein import and the expression of the import motor mitochondrial heat shock protein (mtHsp70).	Triiodothyronine	45-49	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	219-226
12525246-8	2003	When all treatment groups were combined, both plasma cortisol and triiodothyronine concentrations were positively correlated with UCP1 protein abundance.	Triiodothyronine	66-82	mitochondrial brown fat uncoupling protein 1	Ovis aries	130-134
12590734-9	2003	We demonstrate that Sat1 promoter driven basal transcription in OK cells was stimulated by tri-iodothyronine.	Triiodothyronine	91-108	spermidine/spermine N1-acetyl transferase 1	Mus musculus	20-24
12525247-0	2003	Thyroxine and tri-iodothyronine differently affect uncoupling protein-1 content and antioxidant enzyme activities in rat interscapular brown adipose tissue.	Triiodothyronine	14-31	uncoupling protein 1	Rattus norvegicus	51-71
12351640-7	2002	Moreover, the human UCP3 (hUCP3) promoter seems to be fully functional, since triiodothyronine treatment of the mice not only stimulated the mouse UCP3 (mUCP3) mRNA expression but also strongly stimulated the hUCP3 mRNA expression in human fibers formed after myoblast transplantation.	Triiodothyronine	78-94	uncoupling protein 3	Homo sapiens	20-24
12619862-4	2003	Second, in co-transfection experiments in cultured neonatal rat cardiac myocytes, S100A1 inhibited the alpha1-adrenergic activation of promoters of genes induced during the hypertrophic response including the fetal genes skeletal alpha actin (skACT), and beta-myosin heavy chain (MHC) and S100B, but not the triiodothyronine (T3) activation of the promoter of the alpha-MHC gene, that is normally expressed in adult myocardium.	Triiodothyronine	308-324	S100 calcium binding protein A1	Rattus norvegicus	82-88
12351640-7	2002	Moreover, the human UCP3 (hUCP3) promoter seems to be fully functional, since triiodothyronine treatment of the mice not only stimulated the mouse UCP3 (mUCP3) mRNA expression but also strongly stimulated the hUCP3 mRNA expression in human fibers formed after myoblast transplantation.	Triiodothyronine	78-94	uncoupling protein 3	Homo sapiens	26-31
12351640-7	2002	Moreover, the human UCP3 (hUCP3) promoter seems to be fully functional, since triiodothyronine treatment of the mice not only stimulated the mouse UCP3 (mUCP3) mRNA expression but also strongly stimulated the hUCP3 mRNA expression in human fibers formed after myoblast transplantation.	Triiodothyronine	78-94	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	27-31
12351640-7	2002	Moreover, the human UCP3 (hUCP3) promoter seems to be fully functional, since triiodothyronine treatment of the mice not only stimulated the mouse UCP3 (mUCP3) mRNA expression but also strongly stimulated the hUCP3 mRNA expression in human fibers formed after myoblast transplantation.	Triiodothyronine	78-94	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	153-158
12351640-7	2002	Moreover, the human UCP3 (hUCP3) promoter seems to be fully functional, since triiodothyronine treatment of the mice not only stimulated the mouse UCP3 (mUCP3) mRNA expression but also strongly stimulated the hUCP3 mRNA expression in human fibers formed after myoblast transplantation.	Triiodothyronine	78-94	uncoupling protein 3	Homo sapiens	209-214
12475372-3	2002	In vivo administration of triiodothyronine (T(3)) or thyroxine (T(4)) significantly reduced pituitary and serum GH levels, as measured by homologous RIA.	Triiodothyronine	26-42	growth hormone 1	Homo sapiens	112-114
12475372-9	2002	This demonstrated that the inhibition of T(3) on GH synthesis was mediated by a decrease in GH mRNA steady state levels.	Triiodothyronine	41-45	growth hormone 1	Homo sapiens	49-51
12475372-5	2002	Both T(3) and T(4) inhibited GH release in a concentration-dependent manner, producing up to 50% inhibition at 10 nM, with an ED(50) of <0.2 nM, within the range of their physiological circulating levels.	Triiodothyronine	5-9	growth hormone 1	Homo sapiens	29-31
12475372-9	2002	This demonstrated that the inhibition of T(3) on GH synthesis was mediated by a decrease in GH mRNA steady state levels.	Triiodothyronine	41-45	growth hormone 1	Homo sapiens	92-94
12445505-2	2002	The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA).	Triiodothyronine	52-56	insulin	Homo sapiens	61-68
12445505-2	2002	The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA).	Triiodothyronine	52-56	insulin	Homo sapiens	115-122
12445505-2	2002	The MH model characterizes the relationship between T(3) and insulin and the levels of triglycerides (TG), fasting insulin (FI), and fasting glucose (FG) and is introduced as a clinical method to assess insulin sensitivity and the status of metabolic homeostasis in lieu of current screening models advocated by the by American Diabetic Association (ADA).	Triiodothyronine	52-56	insulin	Homo sapiens	115-122
12220730-2	2002	The aim of the present study was to investigate the effects of oxytocin treatment on plasma levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3).	Triiodothyronine	167-183	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	63-71
12588052-1	2002	The stimulation of the uncoupling protein-2 gene (ucp2) by thyroid hormone (triiodothyronine [T3]) in vivo is variable, suggesting complex interactions and even the possibility of indirect effects.	Triiodothyronine	76-92	uncoupling protein 2	Homo sapiens	23-43
12588052-1	2002	The stimulation of the uncoupling protein-2 gene (ucp2) by thyroid hormone (triiodothyronine [T3]) in vivo is variable, suggesting complex interactions and even the possibility of indirect effects.	Triiodothyronine	76-92	uncoupling protein 2	Homo sapiens	50-54
12588052-1	2002	The stimulation of the uncoupling protein-2 gene (ucp2) by thyroid hormone (triiodothyronine [T3]) in vivo is variable, suggesting complex interactions and even the possibility of indirect effects.	Triiodothyronine	94-96	uncoupling protein 2	Homo sapiens	23-43
12588052-1	2002	The stimulation of the uncoupling protein-2 gene (ucp2) by thyroid hormone (triiodothyronine [T3]) in vivo is variable, suggesting complex interactions and even the possibility of indirect effects.	Triiodothyronine	94-96	uncoupling protein 2	Homo sapiens	50-54
12403833-1	2002	Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is regulated by T(3) in a time- and concentration-dependent manner in the developing rat brain and plays an important role in neuronal-specific gene regulation.	Triiodothyronine	71-75	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	7-45
12403833-1	2002	Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is regulated by T(3) in a time- and concentration-dependent manner in the developing rat brain and plays an important role in neuronal-specific gene regulation.	Triiodothyronine	71-75	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	47-53
12403833-2	2002	T(3) treatment, but not retinoic acid (RA), stimulated endogenous CaMKIV mRNA 5-fold in mouse embryonic stem (ES) cells differentiated into neurons.	Triiodothyronine	0-4	calcium/calmodulin-dependent protein kinase IV	Mus musculus	66-72
12593720-0	2002	Differential modulation of liver and pituitary triiodothyronine and 9-cis retinoid acid receptors by insulin-like growth factor I in rats.	Triiodothyronine	47-63	insulin-like growth factor 1	Rattus norvegicus	101-129
12593720-2	2002	It is well known that T(3) activates the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in rats.	Triiodothyronine	22-26	insulin-like growth factor 1	Rattus norvegicus	61-89
12593720-2	2002	It is well known that T(3) activates the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in rats.	Triiodothyronine	22-26	insulin-like growth factor 1	Rattus norvegicus	91-96
12593720-3	2002	In turn, IGF-I inhibits the T(3)-induced GH production in cell cultures.	Triiodothyronine	28-32	insulin-like growth factor 1	Rattus norvegicus	9-14
12395077-1	2002	As a first approach to study the molecular mechanisms that underlie the effects of thyroid hormones on the developing brain, we used a cDNA microarray technology to identify early thyroid hormone-regulated genes in brain neuronal cultures treated with tri-iodothyronine (T3) for 3 h. We identified three genes that were up-regulated by T3, basic transcription element-binding protein, nuclear pore glycoprotein and bone morphogenetic protein-4 and one that was down-regulated, the neuronal apoptosis-inducing gene.	Triiodothyronine	252-269	bone morphogenetic protein 4	Rattus norvegicus	415-443
12102656-1	2002	We identified a thyroid hormone [3,5,3"-tri-iodothyronine (T(3))]-responsive gene, ZAKI-4, in cultured human skin fibroblasts.	Triiodothyronine	33-57	regulator of calcineurin 2	Homo sapiens	83-89
12102656-1	2002	We identified a thyroid hormone [3,5,3"-tri-iodothyronine (T(3))]-responsive gene, ZAKI-4, in cultured human skin fibroblasts.	Triiodothyronine	59-64	regulator of calcineurin 2	Homo sapiens	83-89
12351693-9	2002	Substrates less well transported by OATP-F include T(3), bromosulfophthalein, estrone-3-sulfate, and estradiol-17beta-glucuronide.	Triiodothyronine	51-55	solute carrier organic anion transporter family member 1C1	Homo sapiens	36-42
12381331-4	2002	The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone.	Triiodothyronine	291-308	growth hormone 1	Homo sapiens	36-50
12381331-4	2002	The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone.	Triiodothyronine	291-308	growth hormone 1	Homo sapiens	52-54
12381331-4	2002	The impaired pulsatile secretion of growth hormone (GH), thyrotropin and gonadotropin can be re-amplified by relevant combinations of releasing factors, which also substantially increase circulating levels of insulin-like growth factor (IGF)-I, GH-dependent IGF-binding proteins, thyroxine, tri-iodothyronine, and testosterone.	Triiodothyronine	291-308	insulin like growth factor 1	Homo sapiens	209-243
12030848-1	2002	The kidney androgen-regulated protein (KAP) is specifically expressed and differentially regulated by androgens and tri-iodothyronine (T(3)) in intact mouse early (PCT) and late (PR) proximal-tubule cells.	Triiodothyronine	116-133	kidney androgen regulated protein	Mus musculus	4-37
12030848-1	2002	The kidney androgen-regulated protein (KAP) is specifically expressed and differentially regulated by androgens and tri-iodothyronine (T(3)) in intact mouse early (PCT) and late (PR) proximal-tubule cells.	Triiodothyronine	116-133	kidney androgen regulated protein	Mus musculus	39-42
12030848-1	2002	The kidney androgen-regulated protein (KAP) is specifically expressed and differentially regulated by androgens and tri-iodothyronine (T(3)) in intact mouse early (PCT) and late (PR) proximal-tubule cells.	Triiodothyronine	135-139	kidney androgen regulated protein	Mus musculus	4-37
12030848-1	2002	The kidney androgen-regulated protein (KAP) is specifically expressed and differentially regulated by androgens and tri-iodothyronine (T(3)) in intact mouse early (PCT) and late (PR) proximal-tubule cells.	Triiodothyronine	135-139	kidney androgen regulated protein	Mus musculus	39-42
12200229-5	2002	In a comparative study using CV-1 cells (relatively RXR- and TR-deficient) and JEG-3 cells (relatively TR-deficient), we demonstrate the importance of RXR in the negative transcriptional regulation of genes of the hypothalamo-pituitary axis by tri-iodothyronine.	Triiodothyronine	244-261	retinoid X receptor alpha	Homo sapiens	151-154
12153750-1	2002	OBJECTIVE: Local 5"-deiodination of l-thyroxine (T(4)) to active thyroid hormone 3,3",5-tri-iodothyronine (T(3)) catalyzed by the two 5"-deiodinase enzymes (D1 and D2) regulates various T(3)-dependent functions in the anterior pituitary and has been well studied in rodents.	Triiodothyronine	81-105	leiomodin 1	Homo sapiens	157-166
12153750-1	2002	OBJECTIVE: Local 5"-deiodination of l-thyroxine (T(4)) to active thyroid hormone 3,3",5-tri-iodothyronine (T(3)) catalyzed by the two 5"-deiodinase enzymes (D1 and D2) regulates various T(3)-dependent functions in the anterior pituitary and has been well studied in rodents.	Triiodothyronine	107-111	leiomodin 1	Homo sapiens	157-166
12153750-1	2002	OBJECTIVE: Local 5"-deiodination of l-thyroxine (T(4)) to active thyroid hormone 3,3",5-tri-iodothyronine (T(3)) catalyzed by the two 5"-deiodinase enzymes (D1 and D2) regulates various T(3)-dependent functions in the anterior pituitary and has been well studied in rodents.	Triiodothyronine	186-190	leiomodin 1	Homo sapiens	157-166
12242038-9	2002	In hypothyroid pups, the injection of triiodothyronine (T3) restored normal levels of both mRNAs within 6 h. In 15-day old hypothyroid rats, the amount of NeuroD protein was reduced by about 35%.	Triiodothyronine	38-54	neurogenic differentiation 1	Mus musculus	155-161
12242038-9	2002	In hypothyroid pups, the injection of triiodothyronine (T3) restored normal levels of both mRNAs within 6 h. In 15-day old hypothyroid rats, the amount of NeuroD protein was reduced by about 35%.	Triiodothyronine	56-58	neurogenic differentiation 1	Mus musculus	155-161
12237511-1	2002	The effects of triiodothyronine (T3) on differentiation-dependent expression of GLUT and responses of glucose transport to insulin and norepinephrine (NE) were investigated.	Triiodothyronine	33-35	glutaminase	Rattus norvegicus	80-84
12072404-2	2002	In brain, the presence of type III iodothyronine deiodinase (D3) seems to be important to maintain homeostasis of T(3) levels.	Triiodothyronine	114-118	deiodinase, iodothyronine type III	Gallus gallus	26-59
12180121-2	2002	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3)-induced liver oxidative stress would markedly increase the production of TNF-alpha by Kupffer cells and its release into the circulation.	Triiodothyronine	40-65	tumor necrosis factor	Rattus norvegicus	144-153
12180121-2	2002	Our aim was to test the hypothesis that L-3,3",5-triiodothyronine (T3)-induced liver oxidative stress would markedly increase the production of TNF-alpha by Kupffer cells and its release into the circulation.	Triiodothyronine	67-69	tumor necrosis factor	Rattus norvegicus	144-153
12089358-1	2002	The beta thyroid hormone receptor (TRbeta), but not TRalpha1, plays a specific role in mediating T(3)-dependent repression of hypothalamic TRH transcription.	Triiodothyronine	97-101	thyroid hormone receptor beta	Rattus norvegicus	35-41
11850804-7	2002	Presence of T(3) in the medium caused a gradual increase in the level of p53 in a concentration-dependent manner.	Triiodothyronine	12-16	tumor protein p53	Homo sapiens	73-76
12021188-7	2002	Exposure to BTEB antisense ODNs completely abolished the effects of T(3) on neurite branching and on the elaboration of neuritic filopodia-like structures in acetylcholinesterase cells.	Triiodothyronine	68-72	Kruppel-like factor 9	Rattus norvegicus	12-16
12093154-5	2002	Here we demonstrate that musashi-1 (msi-1) gene is induced by T3 during rat brain development and in N2a cells.	Triiodothyronine	62-64	musashi RNA-binding protein 1	Rattus norvegicus	25-34
12093154-5	2002	Here we demonstrate that musashi-1 (msi-1) gene is induced by T3 during rat brain development and in N2a cells.	Triiodothyronine	62-64	musashi RNA-binding protein 1	Rattus norvegicus	36-41
12093154-8	2002	Furthermore, antisense msi-1 expression inhibited T3 action.	Triiodothyronine	50-52	musashi RNA-binding protein 1	Mus musculus	23-28
12111243-1	2002	The renal sodium-sulfate cotransporter, NaS(i)-1, a protein implicated to control serum sulfate levels, has been shown to be regulated in vivo by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) and tri-iodothyronine (T(3)).	Triiodothyronine	196-213	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	40-48
11934678-0	2002	Triiodothyronine is required for the stimulation of type II 5"-deiodinase mRNA in rat brown adipocytes.	Triiodothyronine	0-16	iodothyronine deiodinase 2	Rattus norvegicus	52-73
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	17-33	cytochrome p450 oxidoreductase	Rattus norvegicus	61-92
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	17-33	cytochrome p450 oxidoreductase	Rattus norvegicus	94-99
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	17-33	cytochrome p450 oxidoreductase	Rattus norvegicus	136-141
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	35-38	cytochrome p450 oxidoreductase	Rattus norvegicus	61-92
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	35-38	cytochrome p450 oxidoreductase	Rattus norvegicus	94-99
11961126-1	2002	Thyroid hormone [triiodothyronine (T3)] positively regulates NADPH cytochrome P450 reductase (P450R) mRNA expression in rat liver, with P450R transcription initiation being a key regulated step.	Triiodothyronine	35-38	cytochrome p450 oxidoreductase	Rattus norvegicus	136-141
11897620-2	2002	We examined the effect of thyroid hormone 3,5,3"-L-triiodothyronine (T(3)) on the activity and expression of PEPT1 in human intestinal Caco-2 cells.	Triiodothyronine	69-73	solute carrier family 15 member 1	Homo sapiens	109-114
11897620-8	2002	These findings indicate that T(3) treatment inhibits the uptake of [(14)C]glycylsarcosine by decreasing the transcription and/or stability of PEPT1 mRNA.	Triiodothyronine	29-33	solute carrier family 15 member 1	Homo sapiens	142-147
11897691-8	2002	Levels of mRNAs for T(3)-responsive genes were determined by Northern blotting: GH and TSH beta in pituitary; type 1 iodothyronine 5"-deiodinase, spot 14 (S14), and malic enzyme in liver; and sarcoplasmic reticulum calcium adenosine triphosphatase 2 and myosin heavy chain alpha and beta in heart.	Triiodothyronine	20-24	thyroid stimulating hormone, beta subunit	Mus musculus	87-95
11897691-8	2002	Levels of mRNAs for T(3)-responsive genes were determined by Northern blotting: GH and TSH beta in pituitary; type 1 iodothyronine 5"-deiodinase, spot 14 (S14), and malic enzyme in liver; and sarcoplasmic reticulum calcium adenosine triphosphatase 2 and myosin heavy chain alpha and beta in heart.	Triiodothyronine	20-24	thyroid hormone responsive	Mus musculus	146-153
11897691-14	2002	Of the four serum parameters, the T(3)-mediated decrease in TSH and changes in AP were attenuated in SRC-1(-/-) mice.	Triiodothyronine	34-38	nuclear receptor coactivator 1	Mus musculus	101-106
11901210-3	2002	LAT1-mediated [(14)C]phenylalanine uptake was strongly inhibited in a competitive manner by aromatic-amino acid derivatives including L-dopa, alpha-methyldopa, melphalan, triiodothyronine, and thyroxine, whereas phenylalanine methyl ester, N-methyl phenylalanine, dopamine, tyramine, carbidopa, and droxidopa did not inhibit [(14)C]phenylalanine uptake.	Triiodothyronine	171-187	solute carrier family 7 member 5 L homeolog	Xenopus laevis	0-4
11867734-4	2002	Prestin(TRE) bound TH receptors as a monomer or presumptive heterodimer and mediated a triiodothyronine-dependent transactivation of a heterologous promotor in response to triiodothyronine receptors alpha and beta.	Triiodothyronine	87-103	solute carrier family 26 member 5	Homo sapiens	0-7
11839528-7	2002	Immunocytochemistry showed that with T(3) treatment, Nkx2.1 and surfactant protein SP-C proteins became progressively localized to cuboidal epithelial cells and mesenchymal expression of Hoxb5 was reduced, a pattern resembling late fetal lung development.	Triiodothyronine	37-41	NK2 homeobox 1	Mus musculus	53-59
11839528-7	2002	Immunocytochemistry showed that with T(3) treatment, Nkx2.1 and surfactant protein SP-C proteins became progressively localized to cuboidal epithelial cells and mesenchymal expression of Hoxb5 was reduced, a pattern resembling late fetal lung development.	Triiodothyronine	37-41	sparse coat	Mus musculus	83-87
11839528-7	2002	Immunocytochemistry showed that with T(3) treatment, Nkx2.1 and surfactant protein SP-C proteins became progressively localized to cuboidal epithelial cells and mesenchymal expression of Hoxb5 was reduced, a pattern resembling late fetal lung development.	Triiodothyronine	37-41	homeobox B5	Mus musculus	187-192
11916278-1	2002	Liver sex hormone-binding globulin (SHBG) biosynthesis is regulated by triiodothyronine (T3).	Triiodothyronine	71-87	sex hormone binding globulin	Homo sapiens	6-34
11916278-1	2002	Liver sex hormone-binding globulin (SHBG) biosynthesis is regulated by triiodothyronine (T3).	Triiodothyronine	71-87	sex hormone binding globulin	Homo sapiens	36-40
11916278-1	2002	Liver sex hormone-binding globulin (SHBG) biosynthesis is regulated by triiodothyronine (T3).	Triiodothyronine	89-91	sex hormone binding globulin	Homo sapiens	6-34
11916278-1	2002	Liver sex hormone-binding globulin (SHBG) biosynthesis is regulated by triiodothyronine (T3).	Triiodothyronine	89-91	sex hormone binding globulin	Homo sapiens	36-40
11916615-1	2002	OBJECTIVE: Search for germline mutations in the thyroxine-binding globulin (TBG) gene of two unrelated Portuguese females of Caucasian origin in whom the diagnosis of TBG deficiency was suspected because of suppressed TSH despite marginally low total thyroxine and tri-iodothyronine.	Triiodothyronine	265-282	serpin family A member 7	Homo sapiens	48-74
11916615-1	2002	OBJECTIVE: Search for germline mutations in the thyroxine-binding globulin (TBG) gene of two unrelated Portuguese females of Caucasian origin in whom the diagnosis of TBG deficiency was suspected because of suppressed TSH despite marginally low total thyroxine and tri-iodothyronine.	Triiodothyronine	265-282	serpin family A member 7	Homo sapiens	76-79
11927393-1	2002	In the sheep fetus, pulmonary and renal concentrations of angiotensin-converting enzyme (ACE) increase towards term in parallel with the prepartum surges in plasma cortisol and tri-iodothyronine (T(3)).	Triiodothyronine	177-194	angiotensin-converting enzyme	Ovis aries	58-87
11927393-1	2002	In the sheep fetus, pulmonary and renal concentrations of angiotensin-converting enzyme (ACE) increase towards term in parallel with the prepartum surges in plasma cortisol and tri-iodothyronine (T(3)).	Triiodothyronine	177-194	angiotensin-converting enzyme	Ovis aries	89-92
11927393-1	2002	In the sheep fetus, pulmonary and renal concentrations of angiotensin-converting enzyme (ACE) increase towards term in parallel with the prepartum surges in plasma cortisol and tri-iodothyronine (T(3)).	Triiodothyronine	196-200	angiotensin-converting enzyme	Ovis aries	58-87
11927393-1	2002	In the sheep fetus, pulmonary and renal concentrations of angiotensin-converting enzyme (ACE) increase towards term in parallel with the prepartum surges in plasma cortisol and tri-iodothyronine (T(3)).	Triiodothyronine	196-200	angiotensin-converting enzyme	Ovis aries	89-92
11927393-6	2002	The ontogenic increment in pulmonary ACE concentration was abolished when the prepartum surge in T(3), but not cortisol, was prevented by fetal thyroidectomy.	Triiodothyronine	97-101	angiotensin-converting enzyme	Ovis aries	37-40
11927393-11	2002	In addition, the prepartum rise in plasma T(3) appears to mediate, in part, the maturational effect of cortisol on pulmonary ACE concentration.	Triiodothyronine	42-46	angiotensin-converting enzyme	Ovis aries	125-128
11901210-5	2002	Although most of the compounds that inhibited LAT1-mediated uptake were able to induce the efflux of [(14)C]phenylalanine preloaded to the oocytes expressing LAT1 through the obligatory exchange mechanism, melphalan, triiodothyronine, and thyroxine did not induce the significant efflux.	Triiodothyronine	217-233	solute carrier family 7 member 5 L homeolog	Xenopus laevis	46-50
11930121-2	2002	We have therefore examined whether 3,5,3"-triiodothyronine (T3) regulates alpha-IN expression in fetal brain neurons in culture.	Triiodothyronine	60-62	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	74-82
11798186-3	2002	Interestingly, treatment of 3T3-L1 cells with 100 nM insulin, 10 ng/ml tumor necrosis factor (TNF) alpha, or 100 nM dexamethasone for 16 h suppressed adiponectin gene expression by about 50 to 85% while angiotensin 2, growth hormone, and triiodothyronine did not have any effect.	Triiodothyronine	238-254	tumor necrosis factor	Mus musculus	71-104
11798186-3	2002	Interestingly, treatment of 3T3-L1 cells with 100 nM insulin, 10 ng/ml tumor necrosis factor (TNF) alpha, or 100 nM dexamethasone for 16 h suppressed adiponectin gene expression by about 50 to 85% while angiotensin 2, growth hormone, and triiodothyronine did not have any effect.	Triiodothyronine	238-254	adiponectin, C1Q and collagen domain containing	Mus musculus	150-161
11850804-9	2002	Supplementation of growth medium with T(3) (1 microM) caused an increase in the rate of proliferation of T47D cells and induced hyperphosphorylation of pRb within 4 h; this effect was maintained for up to 12 h. When ICI 164 384 (ICI) (1 microM), an ER antagonist, was combined with E(2) (1 nM) or T(3) (1 microM), effects of hormones on cell proliferation and hyperphosphorylation of pRb were blocked.	Triiodothyronine	38-42	RB transcriptional corepressor 1	Homo sapiens	152-155
11850804-9	2002	Supplementation of growth medium with T(3) (1 microM) caused an increase in the rate of proliferation of T47D cells and induced hyperphosphorylation of pRb within 4 h; this effect was maintained for up to 12 h. When ICI 164 384 (ICI) (1 microM), an ER antagonist, was combined with E(2) (1 nM) or T(3) (1 microM), effects of hormones on cell proliferation and hyperphosphorylation of pRb were blocked.	Triiodothyronine	38-42	RB transcriptional corepressor 1	Homo sapiens	384-387
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Triiodothyronine	79-95	uncoupling protein 1	Homo sapiens	53-58
11790300-7	2002	The thyroid hormone triiodothyronine (T3), which antagonizes TRH action in the pituitary, also stimulates ERG channel activity through a rapid process that is blocked by Rac1(17N) and wortmannin but not by RhoA(19N).	Triiodothyronine	20-36	thyrotropin releasing hormone	Homo sapiens	61-64
11790300-7	2002	The thyroid hormone triiodothyronine (T3), which antagonizes TRH action in the pituitary, also stimulates ERG channel activity through a rapid process that is blocked by Rac1(17N) and wortmannin but not by RhoA(19N).	Triiodothyronine	20-36	Rac family small GTPase 1	Homo sapiens	170-174
11790300-7	2002	The thyroid hormone triiodothyronine (T3), which antagonizes TRH action in the pituitary, also stimulates ERG channel activity through a rapid process that is blocked by Rac1(17N) and wortmannin but not by RhoA(19N).	Triiodothyronine	38-40	thyrotropin releasing hormone	Homo sapiens	61-64
11790300-7	2002	The thyroid hormone triiodothyronine (T3), which antagonizes TRH action in the pituitary, also stimulates ERG channel activity through a rapid process that is blocked by Rac1(17N) and wortmannin but not by RhoA(19N).	Triiodothyronine	38-40	Rac family small GTPase 1	Homo sapiens	170-174
11790300-7	2002	The thyroid hormone triiodothyronine (T3), which antagonizes TRH action in the pituitary, also stimulates ERG channel activity through a rapid process that is blocked by Rac1(17N) and wortmannin but not by RhoA(19N).	Triiodothyronine	38-40	ras homolog family member A	Homo sapiens	206-210
11739087-5	2002	In the intact fetuses, a decrease in muscle IGF-I gene expression was observed between 127-130 and 142-145 days, which coincided with the normal prepartum surges in plasma cortisol and triiodothyronine (T3).	Triiodothyronine	185-201	insulin-like growth factor I	Ovis aries	44-49
11739087-5	2002	In the intact fetuses, a decrease in muscle IGF-I gene expression was observed between 127-130 and 142-145 days, which coincided with the normal prepartum surges in plasma cortisol and triiodothyronine (T3).	Triiodothyronine	203-205	insulin-like growth factor I	Ovis aries	44-49
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Triiodothyronine	97-99	uncoupling protein 1	Homo sapiens	53-58
12139403-6	2002	Vitamin D (1,25-(OH)2D3) and thyroid hormone (T3) led to an increase in Nas1 promoter activity in OK cells.	Triiodothyronine	46-48	solute carrier family 13 member 1	Homo sapiens	72-76
11786385-6	2002	Whereas the absence of TRalpha alone does not cause resistance to TH, the absence of TRbeta in the presence of TRalpha results in a 205, 169, 544% increase in serum thyroxine (T(4)), triiodothyronine (T(3)) and TSH concentrations respectively.	Triiodothyronine	183-199	apoptosis antagonizing transcription factor	Mus musculus	85-91
11891851-4	2002	In a heterologous promoter context, the DR4-type sequence also acts as a functional RE for the nuclear receptors for 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25OH2D3) and 3,5,3"-triiodothyronine (T3), VDR and T3R.	Triiodothyronine	170-193	major histocompatibility complex, class II, DR beta 4	Homo sapiens	40-43
11891851-4	2002	In a heterologous promoter context, the DR4-type sequence also acts as a functional RE for the nuclear receptors for 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25OH2D3) and 3,5,3"-triiodothyronine (T3), VDR and T3R.	Triiodothyronine	170-193	vitamin D receptor	Homo sapiens	200-203
11891851-4	2002	In a heterologous promoter context, the DR4-type sequence also acts as a functional RE for the nuclear receptors for 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25OH2D3) and 3,5,3"-triiodothyronine (T3), VDR and T3R.	Triiodothyronine	195-197	major histocompatibility complex, class II, DR beta 4	Homo sapiens	40-43
11891851-4	2002	In a heterologous promoter context, the DR4-type sequence also acts as a functional RE for the nuclear receptors for 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25OH2D3) and 3,5,3"-triiodothyronine (T3), VDR and T3R.	Triiodothyronine	195-197	vitamin D receptor	Homo sapiens	200-203
11786385-6	2002	Whereas the absence of TRalpha alone does not cause resistance to TH, the absence of TRbeta in the presence of TRalpha results in a 205, 169, 544% increase in serum thyroxine (T(4)), triiodothyronine (T(3)) and TSH concentrations respectively.	Triiodothyronine	183-199	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	111-118
11713232-8	2001	Third, over-expression of full length NCoR and SMRT in the hypothalamus abolished T(3)-dependent repression of TRH-luciferase.	Triiodothyronine	82-86	nuclear receptor co-repressor 1	Mus musculus	38-42
11800514-6	2001	The pulsatile secretion of growth hormone, thyroid-stimulating hormone, prolactin and luteinizing hormone can be re-established by relevant combinations of releasing factors, which also substantially increase the circulating levels of insulin-like growth factor-1, growth hormone dependent binding proteins, thyroxine, tri-iodothyronine and testosterone.	Triiodothyronine	319-336	growth hormone 1	Homo sapiens	27-41
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	144-160	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	144-160	cytochrome c, somatic	Homo sapiens	82-87
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	162-164	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	162-164	cytochrome c, somatic	Homo sapiens	82-87
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	255-257	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
12841327-4	2002	CsA-sensitive mitochondrial swelling, depolarization, and the release of Ca2+ and Cyt.c were induced by low concentrations of arachidonic acid, triiodothyronine (T3), or 6-hydroxdopamine but not by valinomycin and high concentrations of the fatty acid or T3.	Triiodothyronine	255-257	cytochrome c, somatic	Homo sapiens	82-87
11713232-8	2001	Third, over-expression of full length NCoR and SMRT in the hypothalamus abolished T(3)-dependent repression of TRH-luciferase.	Triiodothyronine	82-86	nuclear receptor co-repressor 2	Mus musculus	47-51
11713232-8	2001	Third, over-expression of full length NCoR and SMRT in the hypothalamus abolished T(3)-dependent repression of TRH-luciferase.	Triiodothyronine	82-86	thyrotropin releasing hormone	Mus musculus	111-114
11742512-3	2001	In quail, TRH caused an increase of triiodothyronine (T(3)) in plasma during the phase of rapid growth, whereas thyroxine (T(4)) concentrations were not affected.	Triiodothyronine	36-52	thyrotropin releasing hormone	Coturnix japonica	10-13
11742512-3	2001	In quail, TRH caused an increase of triiodothyronine (T(3)) in plasma during the phase of rapid growth, whereas thyroxine (T(4)) concentrations were not affected.	Triiodothyronine	54-58	thyrotropin releasing hormone	Coturnix japonica	10-13
11739018-6	2001	SULT1A1*1 activity was more thermostable and more sensitive to NaCl than was SULT1A1*2 activity when assayed with 3,5,3"-triiodothyronine (T(3)).	Triiodothyronine	114-137	sulfotransferase family 1A member 1	Homo sapiens	0-7
11739018-6	2001	SULT1A1*1 activity was more thermostable and more sensitive to NaCl than was SULT1A1*2 activity when assayed with 3,5,3"-triiodothyronine (T(3)).	Triiodothyronine	139-143	sulfotransferase family 1A member 1	Homo sapiens	0-7
11739018-0	2001	Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3",5-triiodothyronine as the substrate.	Triiodothyronine	94-117	sulfotransferase family 1A member 2	Homo sapiens	32-68
11739018-9	2001	SULT1A1*1 activity was significantly higher than the SULT1A1*2 activity with T(3) as the substrate.	Triiodothyronine	77-81	sulfotransferase family 1A member 1	Homo sapiens	0-7
11739018-0	2001	Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3",5-triiodothyronine as the substrate.	Triiodothyronine	94-117	sulfotransferase family 1A member 1	Homo sapiens	70-77
11739018-9	2001	SULT1A1*1 activity was significantly higher than the SULT1A1*2 activity with T(3) as the substrate.	Triiodothyronine	77-81	sulfotransferase family 1A member 1	Homo sapiens	53-60
11604218-1	2001	A single dose of chicken growth hormone (cGH) or dexamethasone acutely increases circulating T(3) levels in 18-day-old chicken embryos through a reduction of hepatic type III iodothyronine deiodinase (D3).	Triiodothyronine	93-97	growth hormone	Gallus gallus	41-44
11719286-12	2001	This is the first report in birds of TRH up-regulation and down-regulation by testosterone and T(3) under in vitro conditions.	Triiodothyronine	95-99	thyrotropin releasing hormone	Anas platyrhynchos	37-40
11544260-5	2001	Our data reveal that T(3) stimulated the proliferation of immature erythroid cells, and inhibited maturation promoted by erythropoietin.	Triiodothyronine	21-25	erythropoietin	Homo sapiens	121-135
11544260-8	2001	Strikingly, a truncated Trip-1 inhibited both erythropoietin-induced maturation and T(3)-initiated cell division.	Triiodothyronine	84-88	proteasome 26S subunit, ATPase 5	Homo sapiens	24-30
11595667-5	2001	These data show that T(3) induces cerebellar astrocytes to secrete mitogenic growth factors, predominantly bFGF, that could influence astrocyte and neuronal proliferation via autocrine and paracrine pathways.	Triiodothyronine	21-25	fibroblast growth factor 2	Homo sapiens	107-111
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Triiodothyronine	107-123	growth hormone 1	Homo sapiens	74-76
11557559-5	2001	SERCA2 protein significantly decreased by 50% in hypothyroid LV and was normalized by T(3) treatment.	Triiodothyronine	86-90	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	0-6
11557559-7	2001	PLB protein expression significantly increased by 1.6- and 5-fold in the hypothyroid LV and atria, respectively, and returned to euthyroid levels with T(3) treatment.	Triiodothyronine	151-155	phospholamban	Rattus norvegicus	0-3
11557559-8	2001	Expression of NCX protein showed a greater response to T(3) treatment in atria tissue than in ventricular tissue.	Triiodothyronine	55-59	solute carrier family 8 member A1	Rattus norvegicus	14-17
11735246-4	2001	In newborn pituitaries, both T3 and hydrocortisone (24 h) caused a dose-dependent increase in GHRH receptor mRNA abundance, reaching levels 4.8-fold (P<0.001) and 6.5-fold (P<0.001) over corresponding controls.	Triiodothyronine	29-31	growth hormone releasing hormone receptor	Rattus norvegicus	94-107
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Triiodothyronine	107-123	growth hormone 1	Homo sapiens	74-76
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Triiodothyronine	125-129	growth hormone 1	Homo sapiens	74-76
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Triiodothyronine	125-129	growth hormone 1	Homo sapiens	74-76
11454868-7	2001	The addition of TR/retinoid X receptor together had no effect on the chromatin structure, but the inclusion of T(3) induced strong positioning of a dinucleosome in the TSH alpha proximal promoter that was bordered by regions that were hypersensitive to cleavage by methidiumpropyl EDTA.	Triiodothyronine	111-115	glycoprotein hormones, alpha polypeptide S homeolog	Xenopus laevis	168-177
11460264-0	2001	Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells.	Triiodothyronine	17-33	jun proto-oncogene	Mus musculus	37-52
11524248-2	2001	Treatment with tri-iodothyronine (T3) (10(-8) M) increased OC mRNA levels by approximately 3-fold after 24 h and reached a maximum, approximately 5.4-fold, after 48 h. The mRNA levels of other bone-specific genes, alkaline phosphatase and osteopontin, were not affected by T3 treatment.	Triiodothyronine	15-32	bone gamma-carboxyglutamate protein	Rattus norvegicus	59-61
11524248-2	2001	Treatment with tri-iodothyronine (T3) (10(-8) M) increased OC mRNA levels by approximately 3-fold after 24 h and reached a maximum, approximately 5.4-fold, after 48 h. The mRNA levels of other bone-specific genes, alkaline phosphatase and osteopontin, were not affected by T3 treatment.	Triiodothyronine	15-32	secreted phosphoprotein 1	Rattus norvegicus	239-250
11524248-2	2001	Treatment with tri-iodothyronine (T3) (10(-8) M) increased OC mRNA levels by approximately 3-fold after 24 h and reached a maximum, approximately 5.4-fold, after 48 h. The mRNA levels of other bone-specific genes, alkaline phosphatase and osteopontin, were not affected by T3 treatment.	Triiodothyronine	34-36	bone gamma-carboxyglutamate protein	Rattus norvegicus	59-61
11524248-2	2001	Treatment with tri-iodothyronine (T3) (10(-8) M) increased OC mRNA levels by approximately 3-fold after 24 h and reached a maximum, approximately 5.4-fold, after 48 h. The mRNA levels of other bone-specific genes, alkaline phosphatase and osteopontin, were not affected by T3 treatment.	Triiodothyronine	34-36	secreted phosphoprotein 1	Rattus norvegicus	239-250
11527418-3	2001	Triiodothyronine (T(3)) markedly induced the phosphorylation of p44/p42 MAP kinase.	Triiodothyronine	0-16	mitogen-activated protein kinase 3	Mus musculus	64-67
11527418-3	2001	Triiodothyronine (T(3)) markedly induced the phosphorylation of p44/p42 MAP kinase.	Triiodothyronine	0-16	cyclin-dependent kinase 20	Mus musculus	68-71
11527418-3	2001	Triiodothyronine (T(3)) markedly induced the phosphorylation of p44/p42 MAP kinase.	Triiodothyronine	18-23	mitogen-activated protein kinase 3	Mus musculus	64-67
11527418-3	2001	Triiodothyronine (T(3)) markedly induced the phosphorylation of p44/p42 MAP kinase.	Triiodothyronine	18-23	cyclin-dependent kinase 20	Mus musculus	68-71
11527418-4	2001	PD98059 and U0126, inhibitors of the upstream kinase that activates p44/p42 MAP kinase, significantly enhanced the T(3)-induced alkaline phosphatase activity in a dose-dependent manner.	Triiodothyronine	115-119	mitogen-activated protein kinase 3	Mus musculus	68-71
11527418-4	2001	PD98059 and U0126, inhibitors of the upstream kinase that activates p44/p42 MAP kinase, significantly enhanced the T(3)-induced alkaline phosphatase activity in a dose-dependent manner.	Triiodothyronine	115-119	cyclin-dependent kinase 20	Mus musculus	72-75
11517013-4	2001	RESULTS: In cells isolated from hyperthyroid (tri-iodothyronine (T(3))-treated) rats, the effect of T(3) treatment on the UCP2 mRNA level varied: it was more than doubled (P<0.05) in acutely T(3)-treated rats but, after chronic (3-week) T(3) treatment, it was only 30% (not statistically significant) above the control (euthyroid) level.	Triiodothyronine	46-63	uncoupling protein 2	Rattus norvegicus	122-126
11517013-4	2001	RESULTS: In cells isolated from hyperthyroid (tri-iodothyronine (T(3))-treated) rats, the effect of T(3) treatment on the UCP2 mRNA level varied: it was more than doubled (P<0.05) in acutely T(3)-treated rats but, after chronic (3-week) T(3) treatment, it was only 30% (not statistically significant) above the control (euthyroid) level.	Triiodothyronine	65-69	uncoupling protein 2	Rattus norvegicus	122-126
11517013-4	2001	RESULTS: In cells isolated from hyperthyroid (tri-iodothyronine (T(3))-treated) rats, the effect of T(3) treatment on the UCP2 mRNA level varied: it was more than doubled (P<0.05) in acutely T(3)-treated rats but, after chronic (3-week) T(3) treatment, it was only 30% (not statistically significant) above the control (euthyroid) level.	Triiodothyronine	100-104	uncoupling protein 2	Rattus norvegicus	122-126
11389679-4	2001	Saturable transport of both L-[(3)H]tryptophan and [(125)I]tri-iodo-L-thyronine in BeWo cells includes components sensitive to inhibition by the System-L-specific substrate 2-endoamino-bicycloheptane-2-carboxylic acid; kinetic properties of these components indicate that the 4F2hc-LAT1 transporter isoform is likely to predominate for the carriage of both substances at physiologically relevant concentrations.	Triiodothyronine	59-79	solute carrier family 3 member 2	Homo sapiens	276-281
11479138-4	2001	In order to understand the role of hormones of the non-steroid superfamily such as 3,5,3"-tri-iodothyronine (T(3)), vitamin D(3) and retinoic acid (RA) in the control of leptin secretion, in the present work doses of 10(-9), 10(-8) and 10(-7) M of these compounds have been studied on in vitro leptin secretion.	Triiodothyronine	83-107	leptin	Homo sapiens	170-176
11454004-6	2001	As demonstrated by Western-blot experiments, administration of tri-iodothyronine to euthyroid rats increases hepatic mGPDH protein concentrations in vivo.	Triiodothyronine	63-80	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	117-122
11431141-4	2001	We have previously shown that triiodothyronine (T(3)) down-regulates pre-pro-TRH gene expression in vivo and in vitro.	Triiodothyronine	30-46	thyrotropin releasing hormone	Rattus norvegicus	73-80
11431141-4	2001	We have previously shown that triiodothyronine (T(3)) down-regulates pre-pro-TRH gene expression in vivo and in vitro.	Triiodothyronine	48-53	thyrotropin releasing hormone	Rattus norvegicus	73-80
11512021-0	2001	Effects of triiodothyronine and bovine growth hormone on glucose transporter isoform-2 (GLUT-2) and glucokinase (GK) gene expression in pancreatic islets of fetal and adult rats.	Triiodothyronine	11-27	solute carrier family 2 member 2	Bos taurus	88-94
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	53-69	solute carrier family 2 member 2	Bos taurus	128-149
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	53-69	solute carrier family 2 member 2	Bos taurus	151-157
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	53-69	glucokinase	Bos taurus	166-177
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	53-69	glucokinase	Bos taurus	179-181
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	71-73	solute carrier family 2 member 2	Bos taurus	128-149
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	71-73	solute carrier family 2 member 2	Bos taurus	151-157
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	71-73	glucokinase	Bos taurus	166-177
11512021-1	2001	This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats.	Triiodothyronine	71-73	glucokinase	Bos taurus	179-181
11454004-7	2001	As it has recently been reported that human mGPDH promoter B is not regulated by tri-iodothyronine, this is the first example of a differentially tri-iodothyronine-regulated orthologous gene promoter in man and rat.	Triiodothyronine	146-163	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	44-49
11389679-4	2001	Saturable transport of both L-[(3)H]tryptophan and [(125)I]tri-iodo-L-thyronine in BeWo cells includes components sensitive to inhibition by the System-L-specific substrate 2-endoamino-bicycloheptane-2-carboxylic acid; kinetic properties of these components indicate that the 4F2hc-LAT1 transporter isoform is likely to predominate for the carriage of both substances at physiologically relevant concentrations.	Triiodothyronine	59-79	solute carrier family 7 member 5	Homo sapiens	282-286
11403889-3	2001	This immature stage persists concomitantly with a dramatic enhancement of aromatase activity reversed by triiodothyronine (T3) either in vivo or in vitro administration.	Triiodothyronine	105-121	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	74-83
11403889-3	2001	This immature stage persists concomitantly with a dramatic enhancement of aromatase activity reversed by triiodothyronine (T3) either in vivo or in vitro administration.	Triiodothyronine	123-125	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	74-83
11693380-8	2001	Triiodothyronine induced c-MDH in the liver at all the ages whereas kidney isoenzyme was induced only at day 60.	Triiodothyronine	0-16	malate dehydrogenase 1	Gallus gallus	25-30
11453524-9	2001	Serum levels of tri-iodothyronine in patients with GD positively correlated with serum concentrations of IL-6 (r = 0.35, p<0.025) and sIL-6R (r = 0.31, p<0.047), while no correlation was found between thyroxine and cytokines.	Triiodothyronine	16-33	interleukin 6	Homo sapiens	105-109
11331145-0	2001	Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.	Triiodothyronine	19-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	88-95
11388423-4	2001	Treatment of the pheochromocytoma-derived cell line PC12 with the thyroid hormone L-3,5,3"-triiodothyronine (T3) decreased SNAP-25 expression.	Triiodothyronine	82-107	synaptosomal-associated protein 25	Mus musculus	123-130
11388423-4	2001	Treatment of the pheochromocytoma-derived cell line PC12 with the thyroid hormone L-3,5,3"-triiodothyronine (T3) decreased SNAP-25 expression.	Triiodothyronine	109-111	synaptosomal-associated protein 25	Mus musculus	123-130
11152480-3	2001	Wild-type TRbeta was mostly nuclear in both the absence and presence of triiodothyronine; however, triiodothyronine induced a nuclear reorganization of TRbeta.	Triiodothyronine	72-88	T cell receptor beta locus	Homo sapiens	10-16
11387028-3	2001	The effect of triiodothyronine (T3) exposure on GST expression was also measured in pyruvate-treated cultures.	Triiodothyronine	14-30	hematopoietic prostaglandin D synthase	Rattus norvegicus	48-51
11387028-3	2001	The effect of triiodothyronine (T3) exposure on GST expression was also measured in pyruvate-treated cultures.	Triiodothyronine	32-34	hematopoietic prostaglandin D synthase	Rattus norvegicus	48-51
11306680-1	2001	Studies were carried out to elucidate the mechanism whereby thyroid hormone (T3) induces NADPH:cytochrome P450 oxidoreductase (P450R) mRNA in rat liver in vivo.	Triiodothyronine	77-79	cytochrome p450 oxidoreductase	Rattus norvegicus	106-133
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	93-109	thyroid peroxidase	Homo sapiens	18-21
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	93-109	thyroglobulin	Homo sapiens	63-65
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	111-113	thyroid peroxidase	Homo sapiens	18-21
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	111-113	thyroglobulin	Homo sapiens	63-65
11411791-7	2001	In 3T3-L1 adipocytes, triiodothyronine significantly increased the expression levels of membrane form of the klotho gene.	Triiodothyronine	22-38	klotho	Homo sapiens	109-115
11440270-0	2001	Regulation of renal growth and IGFBP-4 expression by triiodothyronine during rat development.	Triiodothyronine	53-69	insulin-like growth factor binding protein 4	Rattus norvegicus	31-38
11440270-5	2001	Intraperitoneal triiodothyronine (T3) administration to hypothyroid rats resulted in renal hypertrophy associated with a significant upregulation of IGFBP-4 expression with increased levels of renal IGFBP-4 mRNA and serum protein.	Triiodothyronine	16-32	insulin-like growth factor binding protein 4	Rattus norvegicus	149-156
11440270-5	2001	Intraperitoneal triiodothyronine (T3) administration to hypothyroid rats resulted in renal hypertrophy associated with a significant upregulation of IGFBP-4 expression with increased levels of renal IGFBP-4 mRNA and serum protein.	Triiodothyronine	16-32	insulin-like growth factor binding protein 4	Rattus norvegicus	199-206
11440270-5	2001	Intraperitoneal triiodothyronine (T3) administration to hypothyroid rats resulted in renal hypertrophy associated with a significant upregulation of IGFBP-4 expression with increased levels of renal IGFBP-4 mRNA and serum protein.	Triiodothyronine	34-36	insulin-like growth factor binding protein 4	Rattus norvegicus	149-156
11440270-5	2001	Intraperitoneal triiodothyronine (T3) administration to hypothyroid rats resulted in renal hypertrophy associated with a significant upregulation of IGFBP-4 expression with increased levels of renal IGFBP-4 mRNA and serum protein.	Triiodothyronine	34-36	insulin-like growth factor binding protein 4	Rattus norvegicus	199-206
11440272-3	2001	Administration of L-triiodothyronine (T3, 0.025 to 4 microg/g) in single doses increased the synaptosomal acetylcholinesterase (AchE) and Mg2+-ATPase activity maximally at 24 hours in a dose-dependent way.	Triiodothyronine	18-36	acetylcholinesterase	Rattus norvegicus	128-132
11440272-3	2001	Administration of L-triiodothyronine (T3, 0.025 to 4 microg/g) in single doses increased the synaptosomal acetylcholinesterase (AchE) and Mg2+-ATPase activity maximally at 24 hours in a dose-dependent way.	Triiodothyronine	38-40	acetylcholinesterase	Rattus norvegicus	128-132
11352629-1	2001	We have demonstrated earlier that thyroid hormone (T3) regulates the activity of cholinephosphotransferase (CPT) in guinea pig lung.	Triiodothyronine	51-53	cholinephosphotransferase 1	Cavia porcellus	81-106
11352629-1	2001	We have demonstrated earlier that thyroid hormone (T3) regulates the activity of cholinephosphotransferase (CPT) in guinea pig lung.	Triiodothyronine	51-53	cholinephosphotransferase 1	Cavia porcellus	108-111
11152480-3	2001	Wild-type TRbeta was mostly nuclear in both the absence and presence of triiodothyronine; however, triiodothyronine induced a nuclear reorganization of TRbeta.	Triiodothyronine	99-115	T cell receptor beta locus	Homo sapiens	152-158
11250650-8	2001	CTGF transcript levels were higher in male compared with female rats and were increased in pregnant rats and in rats treated for 5 days with triiodothyronine or dexamethasone.	Triiodothyronine	141-157	cellular communication network factor 2	Rattus norvegicus	0-4
11292661-0	2001	Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3).	Triiodothyronine	85-87	cyclin D1	Rattus norvegicus	0-9
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	37-54	thyrotropin releasing hormone	Mus musculus	134-163
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	37-54	thyrotropin releasing hormone	Mus musculus	165-168
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	37-54	thyrotropin releasing hormone	Mus musculus	333-336
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	56-60	thyrotropin releasing hormone	Mus musculus	134-163
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	56-60	thyrotropin releasing hormone	Mus musculus	165-168
11306605-1	2001	Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback inhibition of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) synthesis in the pituitary and hypothalamus when T(3) binds to thyroid hormone receptors (TRs) interacting with the promoters of the genes for the TSH subunit and TRH.	Triiodothyronine	56-60	thyrotropin releasing hormone	Mus musculus	333-336
11306605-4	2001	Prepro-TRH expression was increased in hypothyroid wild-type mice and markedly suppressed after T(3) administration.	Triiodothyronine	96-100	thyrotropin releasing hormone	Mus musculus	7-10
11306605-7	2001	Thus TR-beta2 is the key TR isoform responsible for T(3)-mediated negative-feedback regulation by hypophysiotropic TRH neurons.	Triiodothyronine	52-56	thyrotropin releasing hormone	Mus musculus	115-118
11299074-0	2001	Influence of vitamin A status on the regulation of uridine (5"-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine.	Triiodothyronine	135-153	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-109
11286572-1	2001	The expression of c- erbAalpha and -beta encoded thyroid hormone receptors (TR) was investigated in rat placenta between 16 and 21 days of gestation (dg), and in fetal liver and brain at 16 dg, using semi-quantitative RT-PCR and nuclear 3,5,3"-triiodothyronine (T(3)) binding.	Triiodothyronine	237-260	thyroid hormone receptor alpha	Rattus norvegicus	18-40
11286572-1	2001	The expression of c- erbAalpha and -beta encoded thyroid hormone receptors (TR) was investigated in rat placenta between 16 and 21 days of gestation (dg), and in fetal liver and brain at 16 dg, using semi-quantitative RT-PCR and nuclear 3,5,3"-triiodothyronine (T(3)) binding.	Triiodothyronine	262-266	thyroid hormone receptor alpha	Rattus norvegicus	18-40
11270884-0	2001	The effects of triiodothyronine augmentation on antithrombin III levels in sepsis.	Triiodothyronine	15-31	serpin family C member 1	Rattus norvegicus	48-64
11444434-0	2001	Regulation of chicken embryonic growth hormone secretion by corticosterone and triiodothyronine: evidence for a negative synergistic response.	Triiodothyronine	79-95	growth hormone	Gallus gallus	32-46
11299074-0	2001	Influence of vitamin A status on the regulation of uridine (5"-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine.	Triiodothyronine	135-153	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	114-120
11299074-7	2001	In rats fed a vitamin A-balanced diet, a single injection of l-T3 (500 microg/kg body weight) increased UGT1A6 mRNA expression whereas this hormone decreased UGT1A1 mRNA expression.	Triiodothyronine	61-65	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	104-110
11299074-8	2001	In addition we observed that the specific effect of l-T3 on UGT1A1 and UGT1A6 was reduced in animals receiving a vitamin A-enriched diet and disappeared in those fed a vitamin A-free diet.	Triiodothyronine	52-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
11299074-8	2001	In addition we observed that the specific effect of l-T3 on UGT1A1 and UGT1A6 was reduced in animals receiving a vitamin A-enriched diet and disappeared in those fed a vitamin A-free diet.	Triiodothyronine	52-56	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	71-77
11306054-2	2001	We first purified a 59-kDa CTBP from Xenopus liver (xCTBP), and found that it is responsible for major [125I]T(3)-binding activity in Xenopus liver cytosol.	Triiodothyronine	109-113	C-terminal binding protein 1 L homeolog	Xenopus laevis	27-31
11171071-1	2001	We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3",5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC.	Triiodothyronine	193-217	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	64-70
11171071-1	2001	We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3",5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC.	Triiodothyronine	193-217	LOC100508689	Homo sapiens	71-76
11171071-1	2001	We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3",5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC.	Triiodothyronine	193-217	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	252-258
11171071-1	2001	We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3",5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC.	Triiodothyronine	219-223	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	64-70
11171071-1	2001	We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that 3,3",5-tri-iodothyronine (T(3)) inhibits the expression of MUC5AC.	Triiodothyronine	219-223	LOC100508689	Homo sapiens	71-76
11171071-10	2001	Consistent with this finding were gel-shift assays revealing a decrease in RAR-retinoic acid response element complexes obtained from T(3)-treated cells.	Triiodothyronine	134-138	retinoic acid receptor alpha	Homo sapiens	75-78
11306054-2	2001	We first purified a 59-kDa CTBP from Xenopus liver (xCTBP), and found that it is responsible for major [125I]T(3)-binding activity in Xenopus liver cytosol.	Triiodothyronine	109-113	C-terminal binding protein 2 like S homeolog	Xenopus laevis	52-57
11306054-6	2001	The recombinant xALDH1 protein exhibited both T(3)-binding activity and ALDH activity converting retinal to retinoic acid (RA), which were similar to those of xCTBP purified from liver cytosol.	Triiodothyronine	46-50	aldehyde dehydrogenase 1 family member A1	Homo sapiens	17-21
11306054-8	2001	Our results demonstrate that xCTBP is identical to ALDH1 and suggest that this protein might modulate RA synthesis and intracellular concentration of free T(3).	Triiodothyronine	155-159	C-terminal binding protein 2 like S homeolog	Xenopus laevis	29-34
11306054-8	2001	Our results demonstrate that xCTBP is identical to ALDH1 and suggest that this protein might modulate RA synthesis and intracellular concentration of free T(3).	Triiodothyronine	155-159	aldehyde dehydrogenase 1 family member A1 L homeolog	Xenopus laevis	51-56
11035025-1	2001	Protein disulfide isomerase (PDI) is a folding assistant of the eukaryotic endoplasmic reticulum, but it also binds the hormones, estradiol, and 3,3",5-triiodo-l-thyronine (T(3)).	Triiodothyronine	145-171	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
11035025-1	2001	Protein disulfide isomerase (PDI) is a folding assistant of the eukaryotic endoplasmic reticulum, but it also binds the hormones, estradiol, and 3,3",5-triiodo-l-thyronine (T(3)).	Triiodothyronine	145-171	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
11035025-1	2001	Protein disulfide isomerase (PDI) is a folding assistant of the eukaryotic endoplasmic reticulum, but it also binds the hormones, estradiol, and 3,3",5-triiodo-l-thyronine (T(3)).	Triiodothyronine	173-177	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
11035025-1	2001	Protein disulfide isomerase (PDI) is a folding assistant of the eukaryotic endoplasmic reticulum, but it also binds the hormones, estradiol, and 3,3",5-triiodo-l-thyronine (T(3)).	Triiodothyronine	173-177	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
11120670-2	2001	In this study, we demonstrated that 6-n-propyl-2-thiouracil (PTU)-induced hypothyroidism stimulated, whereas triido-L-thyronine (T(3))-induced hyperthyroidism suppressed, PC1 mRNA levels in the rat anterior pituitary.	Triiodothyronine	129-134	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	171-174
11120878-8	2001	5-Triiodothyronine (L-T3) given to intact mice produced a greater suppression of serum T(4) in TRalpha(o/o) than it did in WT mice and reduced by a greater amount the TSH response to TSH-releasing hormone.	Triiodothyronine	20-24	trophinin	Mus musculus	95-106
11275680-3	2001	The exposure to T(3) for 12 h produced a significant increase in NF-H expression; whereas incubation with TRH or T(3)+TRH resulted in no change.	Triiodothyronine	16-20	neurofilament heavy chain	Rattus norvegicus	65-69
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	49-53	steroidogenic acute regulatory protein	Mus musculus	99-129
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	49-53	steroidogenic acute regulatory protein	Mus musculus	131-135
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	31-47	steroidogenic acute regulatory protein	Mus musculus	99-129
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	49-53	splicing factor 1	Mus musculus	216-244
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	31-47	steroidogenic acute regulatory protein	Mus musculus	131-135
11145595-1	2001	Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of steroidogenic factor 1 (SF-1).	Triiodothyronine	31-47	splicing factor 1	Mus musculus	216-244
11145595-7	2001	The diminished response in steroidogenesis following chronic T(3) exposure was not a result of alterations in StAR mRNA stability, but rather was due to inhibition of transcription of the StAR gene.	Triiodothyronine	61-65	steroidogenic acute regulatory protein	Mus musculus	110-114
11145595-7	2001	The diminished response in steroidogenesis following chronic T(3) exposure was not a result of alterations in StAR mRNA stability, but rather was due to inhibition of transcription of the StAR gene.	Triiodothyronine	61-65	steroidogenic acute regulatory protein	Mus musculus	188-192
11099489-0	2001	Triiodothyronine-mediated up-regulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes.	Triiodothyronine	0-16	uncoupling protein 2	Homo sapiens	43-47
11099489-0	2001	Triiodothyronine-mediated up-regulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes.	Triiodothyronine	0-16	uncoupling protein 3	Homo sapiens	52-56
11191079-3	2001	Recently, we showed that thyroid hormone 3,5,3"-L-triiodothyronine (T3) also increases androgen-dependent PSA expression, even though androgen receptor expression is not affected.	Triiodothyronine	68-70	kallikrein related peptidase 3	Homo sapiens	106-109
11191079-3	2001	Recently, we showed that thyroid hormone 3,5,3"-L-triiodothyronine (T3) also increases androgen-dependent PSA expression, even though androgen receptor expression is not affected.	Triiodothyronine	68-70	androgen receptor	Homo sapiens	134-151
11309648-1	2001	Thyroid hormone (T3) is an important regulator of gut mucosal development and differentiation, inducing intestinal alkaline phosphatase (IAP) and repressing lactase gene transcription.	Triiodothyronine	17-19	alkaline phosphatase, intestinal	Homo sapiens	104-135
11133928-2	2001	This was done in the context of examining parallel findings concerning the role that thyroid hormone (T(3), 3,5,3"-triiodothyronine) plays in MHC expression.	Triiodothyronine	102-106	major histocompatibility complex, class I, C	Homo sapiens	142-145
11133928-2	2001	This was done in the context of examining parallel findings concerning the role that thyroid hormone (T(3), 3,5,3"-triiodothyronine) plays in MHC expression.	Triiodothyronine	108-131	major histocompatibility complex, class I, C	Homo sapiens	142-145
11309648-1	2001	Thyroid hormone (T3) is an important regulator of gut mucosal development and differentiation, inducing intestinal alkaline phosphatase (IAP) and repressing lactase gene transcription.	Triiodothyronine	17-19	alkaline phosphatase, intestinal	Homo sapiens	137-140
11309648-1	2001	Thyroid hormone (T3) is an important regulator of gut mucosal development and differentiation, inducing intestinal alkaline phosphatase (IAP) and repressing lactase gene transcription.	Triiodothyronine	17-19	lactase	Homo sapiens	157-164
10956641-6	2000	Here, we examine the mechanisms by which thyroid hormone (T3) stimulates CPT-Ialpha gene expression.	Triiodothyronine	58-60	carnitine palmitoyltransferase 1A	Rattus norvegicus	73-83
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	24-40	steroidogenic acute regulatory protein	Mus musculus	85-89
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	24-40	steroidogenic acute regulatory protein	Mus musculus	99-103
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	24-40	splicing factor 1	Mus musculus	200-228
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	42-47	steroidogenic acute regulatory protein	Mus musculus	85-89
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	42-47	steroidogenic acute regulatory protein	Mus musculus	99-103
11384875-3	2001	Treatment of cells with triiodothyronine (T(3)) coordinately augmented the levels of StAR protein, StAR mRNA, and steroid production, and these responses were progressively dependent on expression of steroidogenic factor 1 (SF-1).	Triiodothyronine	42-47	splicing factor 1	Mus musculus	200-228
11384875-8	2001	Importantly, it was found that the SF-1 binding site at position -135 bp of the 5"-flanking region was greatly involved in T(3)-mediated reporter activity.	Triiodothyronine	123-127	splicing factor 1	Mus musculus	35-39
11384875-10	2001	The relevance of T(3)-mediated LHR function was investigated in mice rendered hypo-and hyperthyroid, which accounted for up-regulation in the former and down-regulation in the latter group, respectively.	Triiodothyronine	17-21	luteinizing hormone/choriogonadotropin receptor	Mus musculus	31-34
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	65-81	uncoupling protein 1	Homo sapiens	121-141
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	65-81	uncoupling protein 1	Homo sapiens	143-147
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	83-85	uncoupling protein 1	Homo sapiens	121-141
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	83-85	uncoupling protein 1	Homo sapiens	143-147
11118620-1	2000	High-carbohydrate feeding and triiodothyronine (T3) increase the abundance of acetyl-CoA carboxylase-alpha (ACC alpha) mRNA in avian hepatocytes, whereas starvation, glucagon, and medium-chain fatty acids decrease the abundance of ACC alpha mRNA.	Triiodothyronine	30-46	acetyl-CoA carboxylase alpha	Gallus gallus	78-106
11118620-1	2000	High-carbohydrate feeding and triiodothyronine (T3) increase the abundance of acetyl-CoA carboxylase-alpha (ACC alpha) mRNA in avian hepatocytes, whereas starvation, glucagon, and medium-chain fatty acids decrease the abundance of ACC alpha mRNA.	Triiodothyronine	48-50	acetyl-CoA carboxylase alpha	Gallus gallus	78-106
11147833-1	2000	Thyroxine binding globulin (TBG) is the major carrier of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in plasma.	Triiodothyronine	78-94	serpin family A member 7	Homo sapiens	0-26
11147833-1	2000	Thyroxine binding globulin (TBG) is the major carrier of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in plasma.	Triiodothyronine	78-94	serpin family A member 7	Homo sapiens	28-31
11147833-1	2000	Thyroxine binding globulin (TBG) is the major carrier of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in plasma.	Triiodothyronine	96-98	serpin family A member 7	Homo sapiens	0-26
11147833-1	2000	Thyroxine binding globulin (TBG) is the major carrier of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in plasma.	Triiodothyronine	96-98	serpin family A member 7	Homo sapiens	28-31
11216637-4	2000	Studies with female rat adenohypophyseal cell cultures treated with 3,3",5"-triiodo-L-thyronine (T3) showed that hypothalamic/paracrine factors, including TRH, can also regulate PPII activity.	Triiodothyronine	97-99	thyrotropin releasing hormone	Rattus norvegicus	155-158
11521733-2	2001	Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73 +/- 65 vs. 65 +/- 47 pmol/l, p < 0.005, and 80 +/- 49 vs. 73 +/- 51 ng/l, p < 0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine.	Triiodothyronine	451-467	insulin	Homo sapiens	0-7
11521733-2	2001	Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73 +/- 65 vs. 65 +/- 47 pmol/l, p < 0.005, and 80 +/- 49 vs. 73 +/- 51 ng/l, p < 0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine.	Triiodothyronine	485-501	insulin	Homo sapiens	0-7
11077054-8	2000	SULT1C1 activity obtained with T(3) was used as 100%, and the activities with 3,3"-T(2), rT(3), T(4), and 3,5-diiodothyronine (3, 5-T(2)) were 614, 314, 25, and 4%, respectively.	Triiodothyronine	31-35	sulfotransferase family 1C member 2	Homo sapiens	0-7
11200828-2	2000	As 1,25-dihydroxyvitamin D3, retinoic acid and triiodothyronine are known to exert effects on skin and hair follicle growth through similar receptors, we decided to investigate both the expression pattern of the PPAR alpha, -delta and -gamma subtypes and their role in human hair follicles.	Triiodothyronine	47-63	peroxisome proliferator activated receptor alpha	Homo sapiens	212-241
11084575-5	2000	RESULTS: Plasma triiodothyronine concentrations were significantly higher in lambs treated with thyrotropin-releasing hormone than in control lambs between 3 and 6 hours after birth, as were plasma thyroxine concentrations 1 and 5 hours after birth.	Triiodothyronine	16-32	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	96-125
11075809-1	2000	Thyroid hormone (T3) influences hepatic cholesterol metabolism, and previous studies have established an important role of this hormone in the regulation of cholesterol 7alpha-hydroxylase (CYP7A), the rate-limiting enzyme in the synthesis of bile acids.	Triiodothyronine	17-19	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	157-187
11105553-9	2000	CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck.	Triiodothyronine	166-182	growth hormone 1	Homo sapiens	13-27
11200589-8	2000	In contrast, removal of triiodothyronine (T3) caused an increase in the secretion of mucin and the level of MUC5AC mRNA.	Triiodothyronine	24-40	LOC100508689	Homo sapiens	85-90
11200589-8	2000	In contrast, removal of triiodothyronine (T3) caused an increase in the secretion of mucin and the level of MUC5AC mRNA.	Triiodothyronine	24-40	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	108-114
11200589-8	2000	In contrast, removal of triiodothyronine (T3) caused an increase in the secretion of mucin and the level of MUC5AC mRNA.	Triiodothyronine	42-44	LOC100508689	Homo sapiens	85-90
11200589-8	2000	In contrast, removal of triiodothyronine (T3) caused an increase in the secretion of mucin and the level of MUC5AC mRNA.	Triiodothyronine	42-44	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	108-114
11055982-5	2000	In mouse myocyte cultures, triiodothyronine (T3), norepinephrine (NE) through a beta-adrenergic receptor, and leukemia inhibitory factor induced hypertrophy by a 20% to 30% increase in [(3)H]phenylalanine-labeled protein content.	Triiodothyronine	27-43	leukemia inhibitory factor	Mus musculus	80-136
11055982-5	2000	In mouse myocyte cultures, triiodothyronine (T3), norepinephrine (NE) through a beta-adrenergic receptor, and leukemia inhibitory factor induced hypertrophy by a 20% to 30% increase in [(3)H]phenylalanine-labeled protein content.	Triiodothyronine	45-47	leukemia inhibitory factor	Mus musculus	80-136
11007966-6	2000	The T(3)-dependent binding of GRIP-1 to the TRbeta(1) is disrupted by DEA.	Triiodothyronine	4-8	nuclear receptor coactivator 2	Homo sapiens	30-36
11006954-4	2000	The induction of ICAM-1 by cytokines such as interleukin 1beta or tumour necrosis factor TNF as well as by lipopolysaccharide or T3 can be suppressed by the two anti-inflammatory compounds dexamethasone and parthenolide.	Triiodothyronine	129-131	intercellular adhesion molecule 1	Homo sapiens	17-23
11043608-0	2000	Decreased protein kinase C-epsilon expression in hypertrophied cardiac ventricles induced by triiodothyronine treatment in the rat.	Triiodothyronine	93-109	protein kinase C, epsilon	Rattus norvegicus	10-34
10967617-6	2000	An increase in serum free T3 levels was also found in rats fed a high-fat diet after 15 and 30 d. Statistically significant correlations between serum leptin levels and body fat mass were found after 15, 30 and 60 d of high-fat feeding.	Triiodothyronine	26-28	leptin	Rattus norvegicus	151-157
11074665-1	2000	OBJECTIVE: To examine whether the action of triiodothyronine on aromatase activity in porcine follicular cells is related to the modulation of estradiol receptor.	Triiodothyronine	44-60	estrogen receptor 1	Homo sapiens	143-161
11017772-8	2000	Protein modelling studies are presented that demonstrate differences in the electrostatic characteristics of the molecule in human, rat, chicken, and fish, which may explain why, in contrast to TTR from human and rat, TTR from fish and birds preferentially binds triiodo-l-thyronine.	Triiodothyronine	263-282	transthyretin	Rattus norvegicus	218-221
11017780-8	2000	These results indicate that amphibian TTRs have the ability to bind DES with similar affinity to T(3), the natural ligand, and raise the possibility that DES binding to TTR might induce the temporary elevation of the free concentration of plasma T(3) followed by acceleration of cellular T(3) uptake.	Triiodothyronine	97-101	transthyretin L homeolog	Xenopus laevis	38-41
11017780-8	2000	These results indicate that amphibian TTRs have the ability to bind DES with similar affinity to T(3), the natural ligand, and raise the possibility that DES binding to TTR might induce the temporary elevation of the free concentration of plasma T(3) followed by acceleration of cellular T(3) uptake.	Triiodothyronine	246-250	transthyretin L homeolog	Xenopus laevis	38-41
11017780-8	2000	These results indicate that amphibian TTRs have the ability to bind DES with similar affinity to T(3), the natural ligand, and raise the possibility that DES binding to TTR might induce the temporary elevation of the free concentration of plasma T(3) followed by acceleration of cellular T(3) uptake.	Triiodothyronine	246-250	transthyretin L homeolog	Xenopus laevis	38-41
11041460-5	2000	When liothyronine sodium was administered orally to healthy subjects, serum IL-18 levels were not changed.	Triiodothyronine	5-24	interleukin 18	Homo sapiens	76-81
10911773-8	2000	The higher plasma concentrations of triiodothyronine associated with lower concentrations of insulin could account for the leanness and the elevated diet-induced thermogenesis previously observed in the R+ line.	Triiodothyronine	36-52	insulin	Homo sapiens	93-100
10927625-3	2000	Tri-iodothyronine (T3), thyroxine (T4) and 17beta-oestradiol (OE2) reduced GST activities, whereas testosterone, dihydrotestosterone, and human growth hormone (hGH) had little effect on total GST activity.	Triiodothyronine	0-17	EBF transcription factor 3	Homo sapiens	62-65
10927625-3	2000	Tri-iodothyronine (T3), thyroxine (T4) and 17beta-oestradiol (OE2) reduced GST activities, whereas testosterone, dihydrotestosterone, and human growth hormone (hGH) had little effect on total GST activity.	Triiodothyronine	19-21	growth hormone 1	Homo sapiens	144-158
10856896-0	2000	Tri-iodothyronine induces proliferation in cultured bovine thyroid cells: evidence for the involvement of epidermal growth factor-associated tyrosine kinase activity.	Triiodothyronine	0-17	LOC521832	Bos taurus	106-129
10856896-5	2000	PCNA increased after treatment with T(3) (0.1-5.0 nM) in a concentration-dependent manner.	Triiodothyronine	36-40	proliferating cell nuclear antigen	Bos taurus	0-4
10856896-10	2000	Both, the T(3)-stimulated [(3)H]thymidine incorporation and the TK activity were inhibited by a anti-mouse EGF antibody.	Triiodothyronine	10-14	LOC521832	Bos taurus	107-110
10856896-11	2000	These results lead us to propose that T(3) could operate as a proliferative agent in bovine thyroid cells through a mechanism involving an autocrine/paracrine EGF/EGFR-dependent regulation.	Triiodothyronine	38-42	LOC521832	Bos taurus	159-162
10856896-11	2000	These results lead us to propose that T(3) could operate as a proliferative agent in bovine thyroid cells through a mechanism involving an autocrine/paracrine EGF/EGFR-dependent regulation.	Triiodothyronine	38-42	epidermal growth factor receptor	Bos taurus	163-167
10827021-4	2000	Raising plasma T(3) to prepartum values by exogenous infusion of either T(3) or cortisol into immature intact fetuses prematurely raised hepatic GHR and IGF-I mRNA abundances to values similar to those seen in intact fetuses at 142-145 days.	Triiodothyronine	15-19	growth hormone receptor	Ovis aries	145-148
10827021-4	2000	Raising plasma T(3) to prepartum values by exogenous infusion of either T(3) or cortisol into immature intact fetuses prematurely raised hepatic GHR and IGF-I mRNA abundances to values similar to those seen in intact fetuses at 142-145 days.	Triiodothyronine	15-19	insulin-like growth factor I	Ovis aries	153-158
10827021-4	2000	Raising plasma T(3) to prepartum values by exogenous infusion of either T(3) or cortisol into immature intact fetuses prematurely raised hepatic GHR and IGF-I mRNA abundances to values similar to those seen in intact fetuses at 142-145 days.	Triiodothyronine	72-76	growth hormone receptor	Ovis aries	145-148
10827021-4	2000	Raising plasma T(3) to prepartum values by exogenous infusion of either T(3) or cortisol into immature intact fetuses prematurely raised hepatic GHR and IGF-I mRNA abundances to values similar to those seen in intact fetuses at 142-145 days.	Triiodothyronine	72-76	insulin-like growth factor I	Ovis aries	153-158
10913039-2	2000	T37i cells remain capable of differentiating into brown adipocytes upon insulin and triiodothyronine treatment as judged by their ability to express uncoupling protein 1 and maintain MR expression.	Triiodothyronine	84-100	nuclear receptor subfamily 3, group C, member 2	Mus musculus	183-185
10930442-4	2000	Here we demonstrate that the activation of NF-kappa B by TNF-alpha interferes with thyroid-hormone action as demonstrated by impairment of T(3)-dependent induction of 5"-DI gene expression in HepG2 cells.	Triiodothyronine	139-143	nuclear factor kappa B subunit 1	Homo sapiens	43-53
10930442-4	2000	Here we demonstrate that the activation of NF-kappa B by TNF-alpha interferes with thyroid-hormone action as demonstrated by impairment of T(3)-dependent induction of 5"-DI gene expression in HepG2 cells.	Triiodothyronine	139-143	tumor necrosis factor	Homo sapiens	57-66
10823916-5	2000	UCP3 mRNA and protein levels increased 8.1-fold (+/- 1.1) and 2.8-fold (+/- 0.8), respectively, in the T(3)-treated vs. control rat gastrocnemius muscle.	Triiodothyronine	103-107	uncoupling protein 3	Rattus norvegicus	0-4
11026980-3	2000	As reported here, the major GC-induced increase of TIGR expression in HTM cells is reduced approximately 4-fold by basic fibroblast growth factor (bFGF, 100-1000 pM), with a somewhat smaller inhibition noted with the thyroid hormone triiodothyronine (T3, 100 nM).	Triiodothyronine	233-249	myocilin	Homo sapiens	51-55
10997617-5	2000	Activity and expression of the three UCP"s are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin.	Triiodothyronine	120-137	uncoupling protein 1	Homo sapiens	37-40
10846016-7	2000	Leptin correlated (P < 0.05) with triiodothyronine and insulin but not with estrogen, energy intake, or exercise energy expenditure.	Triiodothyronine	37-53	leptin	Homo sapiens	0-6
11026980-3	2000	As reported here, the major GC-induced increase of TIGR expression in HTM cells is reduced approximately 4-fold by basic fibroblast growth factor (bFGF, 100-1000 pM), with a somewhat smaller inhibition noted with the thyroid hormone triiodothyronine (T3, 100 nM).	Triiodothyronine	251-253	myocilin	Homo sapiens	51-55
11026980-3	2000	As reported here, the major GC-induced increase of TIGR expression in HTM cells is reduced approximately 4-fold by basic fibroblast growth factor (bFGF, 100-1000 pM), with a somewhat smaller inhibition noted with the thyroid hormone triiodothyronine (T3, 100 nM).	Triiodothyronine	251-253	fibroblast growth factor 2	Homo sapiens	147-151
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	53-69	thyroglobulin	Rattus norvegicus	106-108
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	71-73	thyroglobulin	Rattus norvegicus	106-108
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	53-69	thyroglobulin	Rattus norvegicus	142-144
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	71-73	thyroglobulin	Rattus norvegicus	142-144
10698964-6	2000	Stimulation of neonatal cardiomyocytes with triiodothyronine also increased UCP-2 mRNA levels, though only in the presence of fatty acids.	Triiodothyronine	44-60	uncoupling protein 2	Rattus norvegicus	76-81
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	71-73	calmodulin 1	Rattus norvegicus	164-174
10907988-10	2000	Furthermore, trifluoperazine increased the extent of triiodothyronine (T3) release from exogenously added Tg by FRTL-5 cells, indicating that Tg transported in the calmodulin-dependent, megalin-mediated pathway, bypasses the lysosomal pathway.	Triiodothyronine	71-73	LDL receptor related protein 2	Rattus norvegicus	186-193
10767534-8	2000	In triiodothyronine-treated piglets, UCP3 mRNA is more expressed in LT than in RH muscle.	Triiodothyronine	3-19	uncoupling protein 3	Homo sapiens	37-41
10784178-7	2000	In the presence of insulin, stimulation by T3 or hydrocortisone alone had no effect on glycerol 3-phosphate dehydrogenase activity, whereas their concomitant addition significantly increased it.	Triiodothyronine	43-45	insulin	Homo sapiens	19-26
10702363-4	2000	We hypothesized that increased conversion of T(4) to T(3), catalyzed by outer-ring deiodinases (ORD) type-I and -II, is the reason serum T(3) is maintained in rats treated with 3MC or PCB.	Triiodothyronine	53-57	pyruvate carboxylase	Rattus norvegicus	184-187
10780931-2	2000	We studied the role of triiodothyronine (T(3)) on the adrenergic stimulation of UCP mRNA expression by use of primary cultures of rat brown adipocytes.	Triiodothyronine	23-39	uncoupling protein 1	Rattus norvegicus	80-83
10780931-2	2000	We studied the role of triiodothyronine (T(3)) on the adrenergic stimulation of UCP mRNA expression by use of primary cultures of rat brown adipocytes.	Triiodothyronine	41-45	uncoupling protein 1	Rattus norvegicus	80-83
10809234-0	2000	GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor.	Triiodothyronine	39-55	lysine acetyltransferase 2A	Homo sapiens	0-4
10809234-0	2000	GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor.	Triiodothyronine	39-55	glutamate receptor interacting protein 1	Homo sapiens	56-61
10750031-8	2000	In isolated heart mitochondria, T(3) treatment resulted in a 1.8-fold increase in mtHsp70.	Triiodothyronine	32-36	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	82-89
10687864-6	2000	In transiently transfected HeLa cells, TR alpha1 displayed constitutive transactivation in the absence of ligands, which was slightly enhanced by triiodothyronine (T3).	Triiodothyronine	146-162	thyroid hormone receptor alpha a	Danio rerio	39-48
10657854-11	2000	The effect of T(3) on glucose uptake induced by insulin can also be explained by the high expression of both glucose transporters.	Triiodothyronine	14-18	insulin	Homo sapiens	48-55
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	41-57	gonadotropin releasing hormone receptor	Rattus norvegicus	96-98
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	41-57	gonadotropin releasing hormone receptor	Rattus norvegicus	117-119
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	41-57	leptin	Rattus norvegicus	130-136
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	59-61	gonadotropin releasing hormone receptor	Rattus norvegicus	96-98
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	59-61	gonadotropin releasing hormone receptor	Rattus norvegicus	117-119
10690952-5	2000	However, in the presence of insulin plus triiodothyronine (T3), the stimulation of lipolysis by GH was abolished and GH increased leptin release.	Triiodothyronine	59-61	leptin	Rattus norvegicus	130-136
10687864-6	2000	In transiently transfected HeLa cells, TR alpha1 displayed constitutive transactivation in the absence of ligands, which was slightly enhanced by triiodothyronine (T3).	Triiodothyronine	164-166	thyroid hormone receptor alpha a	Danio rerio	39-48
10721822-1	2000	Retinoic acid, vitamin D3 and triiodothyronine regulate keratinocyte proliferation and differentiation--processes that are disturbed in psoriatic skin--via binding to nuclear receptors for retinoic acid (RAR-alpha,-gamma), vitamin D3 (VDR), thyroid hormone (TR-alpha,-beta) plus the common heterodimer partners, the 9-cis-retinoic acid receptors (RXR-alpha,-beta).	Triiodothyronine	30-46	retinoic acid receptor alpha	Homo sapiens	204-256
10721822-1	2000	Retinoic acid, vitamin D3 and triiodothyronine regulate keratinocyte proliferation and differentiation--processes that are disturbed in psoriatic skin--via binding to nuclear receptors for retinoic acid (RAR-alpha,-gamma), vitamin D3 (VDR), thyroid hormone (TR-alpha,-beta) plus the common heterodimer partners, the 9-cis-retinoic acid receptors (RXR-alpha,-beta).	Triiodothyronine	30-46	T cell receptor alpha locus	Homo sapiens	258-266
10721822-1	2000	Retinoic acid, vitamin D3 and triiodothyronine regulate keratinocyte proliferation and differentiation--processes that are disturbed in psoriatic skin--via binding to nuclear receptors for retinoic acid (RAR-alpha,-gamma), vitamin D3 (VDR), thyroid hormone (TR-alpha,-beta) plus the common heterodimer partners, the 9-cis-retinoic acid receptors (RXR-alpha,-beta).	Triiodothyronine	30-46	retinoid X receptor alpha	Homo sapiens	347-356
11271854-15	2000	Treatment of the guinea pigs with 10 mg of tocotrienols (T3) resulted in 48% inhibition of the liver HMGCR activity.	Triiodothyronine	57-59	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Cavia porcellus	101-106
10658938-3	1999	We investigated the hypothesis that central obesity and insulin resistance are linked with an increased blood pressure and insulin production through elevated free serum triiodothyronine concentrations.	Triiodothyronine	170-186	insulin	Homo sapiens	56-63
10536369-2	1999	However, it was reported [Schrader et al., 1994] that, on putative vitamin D response elements (VDREs) within the rat 9k and mouse 28k calcium binding protein genes (rCaBP 9k and mCaBP 28k), VDR and thyroid hormone receptor (TR) form heterodimers that transactivate in response to both 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and triiodothyronine (T(3)).	Triiodothyronine	335-351	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	96-99
10601968-2	1999	A significant dose-dependent increase in IGFBP-4 mRNA levels was observed in Sertoli cells cultured in the presence of physiological concentrations of T(3) or RA.	Triiodothyronine	151-155	insulin like growth factor binding protein 4	Sus scrofa	41-48
10601968-5	1999	Our data establish an important direct role for T(3) and RA in regulating IGFBP-4 expression and consequently IGF activity at the testis level.	Triiodothyronine	48-52	insulin like growth factor binding protein 4	Sus scrofa	74-81
10658938-3	1999	We investigated the hypothesis that central obesity and insulin resistance are linked with an increased blood pressure and insulin production through elevated free serum triiodothyronine concentrations.	Triiodothyronine	170-186	insulin	Homo sapiens	123-130
10658938-7	1999	RESULTS: Free serum triiodothyronine concentrations correlated, independent of age and gender, positively with systolic and diastolic blood pressure, insulin production and fasting insulin.	Triiodothyronine	20-36	insulin	Homo sapiens	150-157
10658938-7	1999	RESULTS: Free serum triiodothyronine concentrations correlated, independent of age and gender, positively with systolic and diastolic blood pressure, insulin production and fasting insulin.	Triiodothyronine	20-36	insulin	Homo sapiens	181-188
10658938-9	1999	The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity.	Triiodothyronine	31-47	insulin	Homo sapiens	69-76
10658938-9	1999	The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity.	Triiodothyronine	31-47	insulin	Homo sapiens	100-107
10658938-9	1999	The correlations of free serum triiodothyronine with blood pressure, insulin production and fasting insulin were independent of the waist:hip ratio and insulin sensitivity.	Triiodothyronine	31-47	insulin	Homo sapiens	100-107
10567719-4	1999	The UCP3 mRNA level was increased when L6 myotubes were treated with increasing concentrations of triiodothyronine (T3), oleic acid, alpha-bromopalmitate and carbacyclin, a non-selective ligand of peroxisome proliferator-activated receptors (PPARs), whereas it was not influenced when treated with selective ligands of PPARalpha (WY 14?	Triiodothyronine	98-114	uncoupling protein 3	Homo sapiens	4-8
10646658-7	1999	The mutant TRbeta had a Ka for triiodothyronine (T3) 30% that of the wild-type TRbeta, approximately a threefold reduction in T3-induced transactivation and a low level dominant negative activity when tested with a positively regulated reporter gene.	Triiodothyronine	31-47	T cell receptor beta locus	Homo sapiens	11-17
10646658-7	1999	The mutant TRbeta had a Ka for triiodothyronine (T3) 30% that of the wild-type TRbeta, approximately a threefold reduction in T3-induced transactivation and a low level dominant negative activity when tested with a positively regulated reporter gene.	Triiodothyronine	49-51	T cell receptor beta locus	Homo sapiens	11-17
10567719-4	1999	The UCP3 mRNA level was increased when L6 myotubes were treated with increasing concentrations of triiodothyronine (T3), oleic acid, alpha-bromopalmitate and carbacyclin, a non-selective ligand of peroxisome proliferator-activated receptors (PPARs), whereas it was not influenced when treated with selective ligands of PPARalpha (WY 14?	Triiodothyronine	116-118	uncoupling protein 3	Homo sapiens	4-8
10560954-7	1999	In vitro expression studies showed that this mutant TRbeta has an impaired triiodothyronine (T3)-dependent transactivation that reduces the activity of the wild-type TRbeta (dominant negative effect).	Triiodothyronine	75-91	T cell receptor beta locus	Homo sapiens	52-58
10518788-9	1999	Scatchard analysis revealed that masu salmon transthyretin possesses a single class of binding site for L-3,5,3"-triiodothyronine, with a Kd of 13.8 nM at 0 degrees C. Taken together with the data reported by Chang et al.	Triiodothyronine	104-129	transthyretin	Homo sapiens	45-58
10595466-5	1999	The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation.	Triiodothyronine	171-187	thyroid hormone receptor beta	Mus musculus	53-59
10595466-5	1999	The PV mutation is a C-insertion at codon 448 of the TRbeta gene and leads to a frame-shift of the carboxyl-terminal 14 amino acids of TRbeta1, resulting in total loss of triiodothyronine (T3) binding and transcriptional activation.	Triiodothyronine	189-191	thyroid hormone receptor beta	Mus musculus	53-59
10498641-5	1999	We show further that T(3) treatment augments proliferation of normal hepatocytes, as evidenced by increased histone 3 mRNA and cyclin-dependent kinase 2 (cdk2) expression, and this is followed by apoptosis.	Triiodothyronine	21-25	cyclin dependent kinase 2	Rattus norvegicus	127-152
10498641-5	1999	We show further that T(3) treatment augments proliferation of normal hepatocytes, as evidenced by increased histone 3 mRNA and cyclin-dependent kinase 2 (cdk2) expression, and this is followed by apoptosis.	Triiodothyronine	21-25	cyclin dependent kinase 2	Rattus norvegicus	154-158
10560954-7	1999	In vitro expression studies showed that this mutant TRbeta has an impaired triiodothyronine (T3)-dependent transactivation that reduces the activity of the wild-type TRbeta (dominant negative effect).	Triiodothyronine	75-91	T cell receptor beta locus	Homo sapiens	166-172
10560954-7	1999	In vitro expression studies showed that this mutant TRbeta has an impaired triiodothyronine (T3)-dependent transactivation that reduces the activity of the wild-type TRbeta (dominant negative effect).	Triiodothyronine	93-95	T cell receptor beta locus	Homo sapiens	52-58
10560954-7	1999	In vitro expression studies showed that this mutant TRbeta has an impaired triiodothyronine (T3)-dependent transactivation that reduces the activity of the wild-type TRbeta (dominant negative effect).	Triiodothyronine	93-95	T cell receptor beta locus	Homo sapiens	166-172
10488052-4	1999	A single large dose of L-triiodothyronine given to hypothyroid rats caused a 4.7-fold increase in myocardial HCN2 mRNA expression level and only a 2.3-fold increase in the beta-actin mRNA level.	Triiodothyronine	23-41	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	109-113
10488052-4	1999	A single large dose of L-triiodothyronine given to hypothyroid rats caused a 4.7-fold increase in myocardial HCN2 mRNA expression level and only a 2.3-fold increase in the beta-actin mRNA level.	Triiodothyronine	23-41	actin, beta	Rattus norvegicus	172-182
10488052-6	1999	Therefore, the increase in rat HCN2 mRNA is likely due to L-triiodothyronine stimulation of HCN2 gene transcription.	Triiodothyronine	58-76	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	31-35
10488052-6	1999	Therefore, the increase in rat HCN2 mRNA is likely due to L-triiodothyronine stimulation of HCN2 gene transcription.	Triiodothyronine	58-76	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	92-96
10465283-0	1999	Triiodothyronine down-regulates thyrotropin-releasing hormone (TRH) synthesis and decreases pTRH-(160-169) and insulin releases from fetal rat islets in culture.	Triiodothyronine	0-16	thyrotropin releasing hormone	Rattus norvegicus	32-61
10484362-0	1999	Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts.	Triiodothyronine	0-16	matrix metallopeptidase 13	Mus musculus	25-38
10484362-0	1999	Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts.	Triiodothyronine	0-16	matrix metallopeptidase 9	Mus musculus	43-55
10465283-0	1999	Triiodothyronine down-regulates thyrotropin-releasing hormone (TRH) synthesis and decreases pTRH-(160-169) and insulin releases from fetal rat islets in culture.	Triiodothyronine	0-16	thyrotropin releasing hormone	Rattus norvegicus	63-66
10465283-4	1999	We found that circulating T3 concentrations were inversely correlated with TRH levels in two physiopathological situations.	Triiodothyronine	26-28	thyrotropin releasing hormone	Rattus norvegicus	75-78
10444435-9	1999	One possible explanation for these data is that T(3) stimulates the leak in vivo but not in vitro because a posttranslational regulator of UCP-2 and -3 is not retained in the mitochondrial fraction.	Triiodothyronine	48-52	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	139-151
10480998-5	1999	Inspection of the 5"-flanking and exon 1 regions of the goldfish TSHbeta gene (1.2 kb) revealed the presence of several putative cis-acting elements, including the negative triiodothyronine (T(3))-responsive element (nTRE), Pit-1 element, and GATA-2 element.	Triiodothyronine	173-189	thyroid stimulating hormone subunit beta	Homo sapiens	65-72
10480998-5	1999	Inspection of the 5"-flanking and exon 1 regions of the goldfish TSHbeta gene (1.2 kb) revealed the presence of several putative cis-acting elements, including the negative triiodothyronine (T(3))-responsive element (nTRE), Pit-1 element, and GATA-2 element.	Triiodothyronine	191-196	thyroid stimulating hormone subunit beta	Homo sapiens	65-72
10455897-9	1999	Concomitant treatment with T3 and butyric acid produced an additive effect on IAP transactivation.	Triiodothyronine	27-29	alkaline phosphatase, intestinal	Homo sapiens	78-81
10427161-0	1999	Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation.	Triiodothyronine	16-33	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-97
10427161-3	1999	Insulin, tri-iodothyronine (T(3)) and norepinephrine, the main regulators of brown adipose tissue function, upregulated GAPDH mRNA levels, whereas retinoic acid inhibited them.	Triiodothyronine	9-26	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	120-125
10427161-3	1999	Insulin, tri-iodothyronine (T(3)) and norepinephrine, the main regulators of brown adipose tissue function, upregulated GAPDH mRNA levels, whereas retinoic acid inhibited them.	Triiodothyronine	28-33	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	120-125
10455897-13	1999	In addition T3 and SCFAs can act in concert to induce IAP gene transcription, demonstrating an important link between triiodothyronine and histone hyperacetylation in regard to enterocyte-specific gene expression.	Triiodothyronine	118-134	alkaline phosphatase, intestinal	Homo sapiens	54-57
10395950-5	1999	Cells at day 1 of culture in insulin, transferrin, triiodothyronine and selenium (ITTS) had increased levels of C/EBPalpha and continued steady high levels to day 6 of culture.	Triiodothyronine	51-67	CCAAT/enhancer binding protein alpha	Rattus norvegicus	112-122
10101242-0	1999	Protein kinase A linked phosphorylation mediates triiodothyronine induced actin gene expression in developing brain.	Triiodothyronine	49-65	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
10503997-0	1999	Triiodothyronine enhances expression of the interleukin-2 receptor alpha chain.	Triiodothyronine	0-16	interleukin 2 receptor subunit alpha	Homo sapiens	44-72
10503997-2	1999	The influence of L-triiodothyronine on expression of the interleukin-2 receptor alpha chain by peripheral blood mononuclear cells from healthy volunteers and YT cells (an interleukin-2 independent natural killer-like cell line) was examined.	Triiodothyronine	17-35	interleukin 2 receptor subunit alpha	Homo sapiens	57-85
10503997-2	1999	The influence of L-triiodothyronine on expression of the interleukin-2 receptor alpha chain by peripheral blood mononuclear cells from healthy volunteers and YT cells (an interleukin-2 independent natural killer-like cell line) was examined.	Triiodothyronine	17-35	interleukin 2	Homo sapiens	57-70
10503997-3	1999	Concanavalin A stimulation significantly (p<0.05 and p<0.01) increased soluble interleukin-2 receptor alpha chain production when mononuclear cells were cultured with triiodothyronine (1-100 nmol/l) for 3 days.	Triiodothyronine	173-189	interleukin 2 receptor subunit alpha	Homo sapiens	85-113
10503997-4	1999	The stimulatory effect of triiodothyronine on interleukin-2 receptor alpha chain expression was greater in the presence of concanavalin A (5 microg/ml) plus interleukin-2 (1 U/ml) than in the presence of concanavalin A alone.	Triiodothyronine	26-42	interleukin 2 receptor subunit alpha	Homo sapiens	46-74
10503997-4	1999	The stimulatory effect of triiodothyronine on interleukin-2 receptor alpha chain expression was greater in the presence of concanavalin A (5 microg/ml) plus interleukin-2 (1 U/ml) than in the presence of concanavalin A alone.	Triiodothyronine	26-42	interleukin 2	Homo sapiens	46-59
10503997-5	1999	Triiodothyronine also significantly (p<0.01) increased interleukin-2 receptor alpha chain expression when YT cells were cultured for 2 days with interleukin-2 (1 U/ml), but did not influence receptor expression when YT cells were cultured with forskolin or 12-O-tetradecanoyl phorbol 13-acetate, potent activators of signal transduction.	Triiodothyronine	0-16	interleukin 2 receptor subunit alpha	Homo sapiens	58-86
10503997-5	1999	Triiodothyronine also significantly (p<0.01) increased interleukin-2 receptor alpha chain expression when YT cells were cultured for 2 days with interleukin-2 (1 U/ml), but did not influence receptor expression when YT cells were cultured with forskolin or 12-O-tetradecanoyl phorbol 13-acetate, potent activators of signal transduction.	Triiodothyronine	0-16	interleukin 2	Homo sapiens	58-71
10503997-6	1999	In conclusion, triiodothyronine may have an immunomodulatory effect by enhancing expression of the interleukin-2 receptor alpha chain on peripheral blood mononuclear cells in the presence of interleukin-2.	Triiodothyronine	15-31	interleukin 2 receptor subunit alpha	Homo sapiens	99-127
10503997-6	1999	In conclusion, triiodothyronine may have an immunomodulatory effect by enhancing expression of the interleukin-2 receptor alpha chain on peripheral blood mononuclear cells in the presence of interleukin-2.	Triiodothyronine	15-31	interleukin 2	Homo sapiens	99-112
10395590-3	1999	The removal of glucose from the culture medium for 40 h resulted in significant reductions (to 45% of control, P = 0.013) in the expression of GHR in the presence of growth hormone (GH), dexamethasone (DEX) and tri-iodothyronine (T3).	Triiodothyronine	211-228	growth hormone receptor	Sus scrofa	143-146
10395590-3	1999	The removal of glucose from the culture medium for 40 h resulted in significant reductions (to 45% of control, P = 0.013) in the expression of GHR in the presence of growth hormone (GH), dexamethasone (DEX) and tri-iodothyronine (T3).	Triiodothyronine	230-232	growth hormone receptor	Sus scrofa	143-146
10395590-7	1999	Removal of arginine, proline, threonine, tryptophan or valine inhibited the stimulation of IGF-I expression that was induced by the combination of T3, DEX and GH (to 15, 6, 11, 16 and 16% of control, respectively, P < 0.05), with significant decreases in GHR expression also observed in some cases.	Triiodothyronine	147-149	insulin like growth factor 1	Sus scrofa	91-96
10395590-7	1999	Removal of arginine, proline, threonine, tryptophan or valine inhibited the stimulation of IGF-I expression that was induced by the combination of T3, DEX and GH (to 15, 6, 11, 16 and 16% of control, respectively, P < 0.05), with significant decreases in GHR expression also observed in some cases.	Triiodothyronine	147-149	growth hormone receptor	Sus scrofa	258-261
10400398-5	1999	These precocious expressions correlated with the lower responsiveness to exogenously added triiodo-L-thyronine (T3) for inducing a high level of TRbeta mRNA expression.	Triiodothyronine	91-110	thyroid hormone receptor, beta S homeolog	Xenopus laevis	145-151
10400398-5	1999	These precocious expressions correlated with the lower responsiveness to exogenously added triiodo-L-thyronine (T3) for inducing a high level of TRbeta mRNA expression.	Triiodothyronine	112-114	thyroid hormone receptor, beta S homeolog	Xenopus laevis	145-151
10333549-0	1999	Tri-iodothyronine increases insulin-like growth factor binding protein-2 expression in cultured hepatocytes from hypothyroid rats.	Triiodothyronine	0-17	insulin-like growth factor binding protein 2	Rattus norvegicus	28-72
10411325-4	1999	Both, type I and type II 5"-deiodinase generate the thyromimetically active hormone 3,3",5-triiodothyronine (T3) by reductive deiodination of the phenolic ring of T4.	Triiodothyronine	84-107	iodothyronine deiodinase 2	Homo sapiens	6-38
10411325-4	1999	Both, type I and type II 5"-deiodinase generate the thyromimetically active hormone 3,3",5-triiodothyronine (T3) by reductive deiodination of the phenolic ring of T4.	Triiodothyronine	109-111	iodothyronine deiodinase 2	Homo sapiens	6-38
10431396-1	1999	Kinetics of triiodothyronine (T3) induced changes were studied in cytoplasmic malate dehydrogenase (cMDH), mitochondrial malate dehydrogenase (mMDH) and lactate dehydrogenase (LDH) of the liver and skeletal muscle of a catfish, Clarias batrachus.	Triiodothyronine	12-28	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	143-147
10431396-1	1999	Kinetics of triiodothyronine (T3) induced changes were studied in cytoplasmic malate dehydrogenase (cMDH), mitochondrial malate dehydrogenase (mMDH) and lactate dehydrogenase (LDH) of the liver and skeletal muscle of a catfish, Clarias batrachus.	Triiodothyronine	30-32	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	143-147
10191252-7	1999	Using Caco-2/TC7 cells stably transformed with various fragments of the GLUT5 promoter inserted upstream of the luciferase reporter gene, we localized the sequences that confer 3,3",5-l-tri-iodothyronine (T3)- and/or glucose-sensitivity to the gene.	Triiodothyronine	205-207	solute carrier family 2 member 5	Homo sapiens	72-77
10199819-9	1999	These findings suggest that, even though the bulk of the thyroid hormone responsiveness of the gene is contained within the first 215 bp of the beta-MHC promoter sequence, the exact mechanism of triiodothyronine (T3) action remains to be elucidated.	Triiodothyronine	195-211	major histocompatibility complex, class I, C	Homo sapiens	149-152
10199819-9	1999	These findings suggest that, even though the bulk of the thyroid hormone responsiveness of the gene is contained within the first 215 bp of the beta-MHC promoter sequence, the exact mechanism of triiodothyronine (T3) action remains to be elucidated.	Triiodothyronine	213-215	major histocompatibility complex, class I, C	Homo sapiens	149-152
10085078-4	1999	Here we show that xCTBP was co-purified with ALDH and 3,3",5-triiodo-L-thyronine (T3) binding activities.	Triiodothyronine	54-80	C-terminal binding protein 2 like S homeolog	Xenopus laevis	18-23
10097258-1	1999	BACKGROUND: Local 5"-deiOdination of l-thyroxine (T4) to the active thyroid hormone, 3,3",5-tri-iodothyronine (T3) via two deiodinase isoenzymes (D1 and D2) has an important role for various T3-dependent functions in the anterior pituitary.	Triiodothyronine	111-113	leiomodin 1	Homo sapiens	146-155
10202153-6	1999	In contrast, the decline of TSH by treatment with L-triiodothyronine was severely blunted in SRC-1(-/-) mice.	Triiodothyronine	50-68	nuclear receptor coactivator 1	Mus musculus	93-98
10085078-4	1999	Here we show that xCTBP was co-purified with ALDH and 3,3",5-triiodo-L-thyronine (T3) binding activities.	Triiodothyronine	82-84	C-terminal binding protein 2 like S homeolog	Xenopus laevis	18-23
10022577-1	1999	Analyzing the thyroid hormone (TH)-dependent period of the inner ear, we observed that the presence of triiodothyronine (T3) between postnatal day 3 (P3) and P12 is sufficient for functional maturation of the auditory system.	Triiodothyronine	121-123	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	158-161
10198194-2	1999	We investigated isolated adult rat cardiomyocytes in a primary culture exposed (T3-cells) or not exposed to (control cells) 10(-8) M triiodothyronine (T3) for 48 h. Northern blot analysis revealed reciprocal alterations in the expression of SERCA2 and phospholamban.	Triiodothyronine	133-149	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	241-247
10026215-3	1999	Triiodothyronine (T3) induced a approximately 3.6-fold increase in the steady-state level of StAR mRNA which paralleled with those of the acute steroid response ( approximately 4.0-fold), as monitored by quantitative reverse transcriptase-polymerase chain reaction assay and progesterone production, respectively.	Triiodothyronine	0-16	steroidogenic acute regulatory protein	Mus musculus	93-97
10026215-3	1999	Triiodothyronine (T3) induced a approximately 3.6-fold increase in the steady-state level of StAR mRNA which paralleled with those of the acute steroid response ( approximately 4.0-fold), as monitored by quantitative reverse transcriptase-polymerase chain reaction assay and progesterone production, respectively.	Triiodothyronine	18-20	steroidogenic acute regulatory protein	Mus musculus	93-97
10023667-2	1999	As Krox-24 is expressed in brain areas showing post-natal neurogenesis during a thyroid hormone (T3)-sensitive period, we followed T3 effects on Krox-24 expression in newborn mice.	Triiodothyronine	97-99	early growth response 1	Mus musculus	3-10
10050769-1	1999	We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity.	Triiodothyronine	52-68	uncoupling protein 3	Rattus norvegicus	97-117
10050769-1	1999	We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity.	Triiodothyronine	52-68	uncoupling protein 3	Rattus norvegicus	119-123
10050769-1	1999	We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity.	Triiodothyronine	70-72	uncoupling protein 3	Rattus norvegicus	97-117
10050769-1	1999	We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity.	Triiodothyronine	70-72	uncoupling protein 3	Rattus norvegicus	119-123
9929502-0	1999	Cytochrome P-450 mRNAs are modulated by dehydroepiandrosterone, nafenopin, and triiodothyronine.	Triiodothyronine	79-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
10090317-6	1999	The T329N mutation, which was also identified in the daughter, markedly reduces the affinity of TRbeta for triiodothyronine (T3).	Triiodothyronine	107-123	T cell receptor beta locus	Homo sapiens	96-102
10090317-6	1999	The T329N mutation, which was also identified in the daughter, markedly reduces the affinity of TRbeta for triiodothyronine (T3).	Triiodothyronine	4-6	T cell receptor beta locus	Homo sapiens	96-102
10195688-0	1999	Regulation of human growth hormone receptor gene transcription by triiodothyronine (T3).	Triiodothyronine	66-82	growth hormone receptor	Homo sapiens	20-43
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	34-50	growth hormone receptor	Homo sapiens	177-181
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	52-54	growth hormone receptor	Homo sapiens	141-152
10195688-0	1999	Regulation of human growth hormone receptor gene transcription by triiodothyronine (T3).	Triiodothyronine	84-86	growth hormone receptor	Homo sapiens	20-43
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	52-54	growth hormone receptor	Homo sapiens	173-176
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	34-50	growth hormone receptor	Homo sapiens	141-152
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	52-54	growth hormone receptor	Homo sapiens	177-181
10195688-1	1999	In this study the hypothesis that triiodothyronine (T3) and growth hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested.	Triiodothyronine	34-50	growth hormone receptor	Homo sapiens	173-176
10195691-3	1999	injection of chicken GH or glucocorticoids results in increased plasma 3,3",5-triiodothyronine (T3) concentrations, and this through a reduction of hepatic type III iodothyronine deiodinase (D3) activity.	Triiodothyronine	71-94	growth hormone	Gallus gallus	21-23
9990293-0	1999	Alteration of heart uncoupling protein-2 mRNA regulated by sympathetic nerve and triiodothyronine during postnatal period in rats.	Triiodothyronine	81-97	uncoupling protein 2	Rattus norvegicus	20-40
10195691-3	1999	injection of chicken GH or glucocorticoids results in increased plasma 3,3",5-triiodothyronine (T3) concentrations, and this through a reduction of hepatic type III iodothyronine deiodinase (D3) activity.	Triiodothyronine	71-94	deiodinase, iodothyronine type III	Gallus gallus	156-189
10195691-3	1999	injection of chicken GH or glucocorticoids results in increased plasma 3,3",5-triiodothyronine (T3) concentrations, and this through a reduction of hepatic type III iodothyronine deiodinase (D3) activity.	Triiodothyronine	96-98	growth hormone	Gallus gallus	21-23
9990293-5	1999	The studies using cultured cardiomyocytes demonstrated that both 10(-8) M triiodothyronine and 10(-7) M isoproterenol, but not phenylephrine, increased UCP2 mRNA expression.	Triiodothyronine	74-90	uncoupling protein 2	Rattus norvegicus	152-156
10566174-3	1999	Total triiodothyronine levels before anti-tuberculosis therapy were inversely correlated with levels of serum soluble interleukin-2 receptors.	Triiodothyronine	6-22	interleukin 2	Homo sapiens	118-131
9886925-2	1999	We used a renal epithelial cell line, the opossum kidney (OK) cell, to define the mechanism by which 3,5,3"-triiodothyronine (T3) increases NHE3 activity.	Triiodothyronine	101-124	solute carrier family 9 member A3	Rattus norvegicus	140-144
9886965-0	1999	3,5,3"-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.	Triiodothyronine	0-23	uncoupling protein 1	Rattus norvegicus	44-47
9886925-2	1999	We used a renal epithelial cell line, the opossum kidney (OK) cell, to define the mechanism by which 3,5,3"-triiodothyronine (T3) increases NHE3 activity.	Triiodothyronine	126-128	solute carrier family 9 member A3	Rattus norvegicus	140-144
9916139-5	1999	Transgenic mice developed profound pituitary resistance to thyroid hormone, as demonstrated by markedly elevated baseline and non-triodothyronine (T3)-suppressible serum TSH and pituitary TSH-beta mRNA.	Triiodothyronine	147-149	thyroid stimulating hormone, beta subunit	Mus musculus	188-196
10696826-0	1999	Dexamethasone represses 3,5,3"-triiodothyronine-stimulated expression of intercellular adhesion molecule-1 in the human cell line ECV 304.	Triiodothyronine	24-47	intercellular adhesion molecule 1	Homo sapiens	73-106
10696826-1	1999	The effect of the thyroid hormone L-3,5,3"-triiodothyronine (T3) on the expression of ICAM-1, a cell surface glycoprotein playing a pivotal role in inflammatory responses, was investigated.	Triiodothyronine	34-59	intercellular adhesion molecule 1	Homo sapiens	86-92
10696826-1	1999	The effect of the thyroid hormone L-3,5,3"-triiodothyronine (T3) on the expression of ICAM-1, a cell surface glycoprotein playing a pivotal role in inflammatory responses, was investigated.	Triiodothyronine	61-63	intercellular adhesion molecule 1	Homo sapiens	86-92
10077348-0	1999	Serum leptin concentrations during short-term administration of growth hormone and triiodothyronine in healthy adults: a randomised, double-blind placebo-controlled study.	Triiodothyronine	83-99	leptin	Homo sapiens	6-12
10077348-12	1999	Growth hormone administration furthermore increases the peripheral conversion of thyroxine to triiodothyronine, which may contribute to the overall actions of GH on fuel and energy metabolism.	Triiodothyronine	94-110	growth hormone 1	Homo sapiens	0-14
10077348-12	1999	Growth hormone administration furthermore increases the peripheral conversion of thyroxine to triiodothyronine, which may contribute to the overall actions of GH on fuel and energy metabolism.	Triiodothyronine	94-110	growth hormone 1	Homo sapiens	159-161
9867832-1	1999	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by thyroid hormone (T3) and cAMP.	Triiodothyronine	106-108	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	30-63
9867832-1	1999	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by thyroid hormone (T3) and cAMP.	Triiodothyronine	106-108	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	65-70
10209562-12	1998	Furthermore, the increase in serum IGF-I, IGF-II, and triiodothyronine correlated with the increase in IGFBP-3.	Triiodothyronine	54-70	insulin like growth factor binding protein 3	Homo sapiens	103-110
10363569-8	1999	CONCLUSIONS: Triiodothyronine, thyroxine, LHRH and gastrin may increase or decrease cell proliferation in human thyroid tissues, whether benign or malignant, to the same extent as other hormones and/or growth factors such as thyrotropin, EGF, insulin-like growth factor 1, transforming growth factor beta1 and estradiol the effects of which on thyroid cell proliferation are already well documented in the literature.	Triiodothyronine	13-29	epidermal growth factor	Homo sapiens	238-241
10363569-8	1999	CONCLUSIONS: Triiodothyronine, thyroxine, LHRH and gastrin may increase or decrease cell proliferation in human thyroid tissues, whether benign or malignant, to the same extent as other hormones and/or growth factors such as thyrotropin, EGF, insulin-like growth factor 1, transforming growth factor beta1 and estradiol the effects of which on thyroid cell proliferation are already well documented in the literature.	Triiodothyronine	13-29	insulin like growth factor 1	Homo sapiens	243-305
9879714-6	1998	The possibility of using this technique to evaluate physiological regulations was approached by examining the effects of tri-iodothyronine (T3), on transcription from the mammalian TRH and Krox-24 promoter sequences.	Triiodothyronine	121-138	early growth response 1	Homo sapiens	189-196
9920365-3	1998	Elevated serum SHBG concentration was more frequent in patients with serum total thyroxine (TT4) concentrations greater than 15.0 microg/dL (32/39 [82%]; including 3 patients with autonomous adenoma) compared to those with serum TT4 concentration between 11.0 and 15.0 microg/dL (21/27 [77%]; including 7 patients with autonomous adenoma), or patients with an isolated elevation of serum total triiodothyronine (TT3) concentration (4/16 [25%]; including 2 patients with autonomous adenoma).	Triiodothyronine	394-410	sex hormone binding globulin	Homo sapiens	15-19
9832432-7	1998	Treatment with L-T3 (0.5 to 25 microg/mouse/day) caused a 57% decrease in serum cholesterol and a 231% increase in serum AP in the TR beta+/+ mice.	Triiodothyronine	15-19	apoptosis antagonizing transcription factor	Mus musculus	131-138
9832432-8	1998	The TR beta-/- mice were resistant to the L-T3 induced changes in serum cholesterol and showed increase in AP only with the highest L-T3 dose.	Triiodothyronine	42-46	apoptosis antagonizing transcription factor	Mus musculus	4-11
9832432-8	1998	The TR beta-/- mice were resistant to the L-T3 induced changes in serum cholesterol and showed increase in AP only with the highest L-T3 dose.	Triiodothyronine	132-136	apoptosis antagonizing transcription factor	Mus musculus	4-11
9893018-5	1998	At follow-up, patients with normal plasma free thyroxine (T4) and total tri-iodothyronine (T3) showed similar plasma levels of t-PA, PAI-1, vWF and release of t-PA from endothelial cells as the control subjects (P > 0.05).	Triiodothyronine	72-89	chromosome 20 open reading frame 181	Homo sapiens	159-163
9879714-6	1998	The possibility of using this technique to evaluate physiological regulations was approached by examining the effects of tri-iodothyronine (T3), on transcription from the mammalian TRH and Krox-24 promoter sequences.	Triiodothyronine	140-142	early growth response 1	Homo sapiens	189-196
9770474-1	1998	To investigate the regulation of the human fatty acid synthase gene by the thyroid hormone triiodothyronine, various constructs of the human fatty acid synthase promoter and the luciferase reporter gene were transfected in combination with plasmids expressing the thyroid hormone and the retinoid X receptors in HepG2 cells.	Triiodothyronine	91-107	fatty acid synthase	Homo sapiens	43-62
9856405-6	1998	beta-Hydroxybutyrate increased quadratically with phlorizin injection during 2 to 24 h and tended to increase quadratically during 8 to 72 h. The ratio of insulin to glucagon tended to decrease linearly with phlorizin injection during the 1st 24 h but was unaffected from 8 to 72 h. Triiodothyronine, but not thyroxine, tended to decrease linearly with phlorizin injection during 8 to 72 h. Cortisol was not affected by treatment.	Triiodothyronine	283-299	insulin	Homo sapiens	155-162
9827660-12	1998	Quantitative in situ hybridization showed a positive correlation of total TRH mRNA in the PVN and serum concentrations of TSH and triiodothyronine (T3) less than 24 hours before death, supporting our hypothesis.	Triiodothyronine	130-146	thyrotropin releasing hormone	Homo sapiens	74-77
9827660-12	1998	Quantitative in situ hybridization showed a positive correlation of total TRH mRNA in the PVN and serum concentrations of TSH and triiodothyronine (T3) less than 24 hours before death, supporting our hypothesis.	Triiodothyronine	148-150	thyrotropin releasing hormone	Homo sapiens	74-77
9827656-1	1998	Mechanisms of triiodothyronine (T3) negative regulation of the human thyrotropin-releasing hormone (TRH) gene were investigated with a chimeric construct of the 5" flanking region fused to a luciferase reporter gene, transfected into human neuroblastoma cells (HTB-11).	Triiodothyronine	14-30	thyrotropin releasing hormone	Homo sapiens	69-98
9827656-1	1998	Mechanisms of triiodothyronine (T3) negative regulation of the human thyrotropin-releasing hormone (TRH) gene were investigated with a chimeric construct of the 5" flanking region fused to a luciferase reporter gene, transfected into human neuroblastoma cells (HTB-11).	Triiodothyronine	14-30	thyrotropin releasing hormone	Homo sapiens	100-103
9827656-1	1998	Mechanisms of triiodothyronine (T3) negative regulation of the human thyrotropin-releasing hormone (TRH) gene were investigated with a chimeric construct of the 5" flanking region fused to a luciferase reporter gene, transfected into human neuroblastoma cells (HTB-11).	Triiodothyronine	32-34	thyrotropin releasing hormone	Homo sapiens	69-98
9789798-1	1998	Effect of triiodothyronine on mitochondrial cytochrome P450-scc activity.	Triiodothyronine	10-26	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	44-63
9827656-1	1998	Mechanisms of triiodothyronine (T3) negative regulation of the human thyrotropin-releasing hormone (TRH) gene were investigated with a chimeric construct of the 5" flanking region fused to a luciferase reporter gene, transfected into human neuroblastoma cells (HTB-11).	Triiodothyronine	32-34	thyrotropin releasing hormone	Homo sapiens	100-103
9809870-0	1998	The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone.	Triiodothyronine	106-122	thyrotropin releasing hormone	Mus musculus	4-33
9809870-3	1998	Subcutaneous administration of these "TRH-like" peptides in male and female CDI mice led to increased levels of triiodothyronine (T3) and to a lesser extent tetraiodothyronine (T4) in the circulation.	Triiodothyronine	112-128	thyrotropin releasing hormone	Mus musculus	38-41
9809870-3	1998	Subcutaneous administration of these "TRH-like" peptides in male and female CDI mice led to increased levels of triiodothyronine (T3) and to a lesser extent tetraiodothyronine (T4) in the circulation.	Triiodothyronine	130-132	thyrotropin releasing hormone	Mus musculus	38-41
9729472-1	1998	The expression of the Na+/glucose cotransporter (SGLT1) in response to thyroid hormone [3,5,3"-tri-iodo-l-thyronine (T3)] was investigated in the enterocytic model cell line Caco-2/TC7.	Triiodothyronine	88-115	solute carrier family 5 member 1	Homo sapiens	49-54
9729472-1	1998	The expression of the Na+/glucose cotransporter (SGLT1) in response to thyroid hormone [3,5,3"-tri-iodo-l-thyronine (T3)] was investigated in the enterocytic model cell line Caco-2/TC7.	Triiodothyronine	117-119	solute carrier family 5 member 1	Homo sapiens	49-54
9789798-2	1998	In the present study hydroxylated cholesterol derivatives were used to monitor P450scc activity as an effect of triiodothyronine.	Triiodothyronine	112-128	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	79-86
9688704-3	1998	In this study we found that when 3,5, 3"-triiodothyronine (T3) was given once a day, there was a parallel increase in heart rate (occurring 1 day later in the TRalpha1-deficient mice than in controls) and body temperature.	Triiodothyronine	59-61	thyroid hormone receptor alpha	Mus musculus	159-167
9712861-11	1998	The oatp2 and oatp3 cRNA-injected oocytes also showed significant uptake of both thyroxine and triiodothyronine.	Triiodothyronine	95-111	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	4-9
9712861-11	1998	The oatp2 and oatp3 cRNA-injected oocytes also showed significant uptake of both thyroxine and triiodothyronine.	Triiodothyronine	95-111	solute carrier organic anion transporter family, member 1A5	Rattus norvegicus	14-19
9712728-0	1998	Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene.	Triiodothyronine	11-27	low density lipoprotein receptor	Homo sapiens	72-84
9688886-2	1998	In intact fetuses, a significant decrease in hepatic IGF-II mRNA abundance was observed between 127-130 and 142-145 days of gestation, which coincided with the normal prepartum rise in plasma cortisol and triiodothyronine (T3) concentrations.	Triiodothyronine	205-221	insulin-like growth factor II	Ovis aries	53-59
9717981-2	1998	Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis.	Triiodothyronine	72-88	thyroglobulin	Homo sapiens	6-8
9717981-2	1998	Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis.	Triiodothyronine	90-92	thyroglobulin	Homo sapiens	6-8
9688886-2	1998	In intact fetuses, a significant decrease in hepatic IGF-II mRNA abundance was observed between 127-130 and 142-145 days of gestation, which coincided with the normal prepartum rise in plasma cortisol and triiodothyronine (T3) concentrations.	Triiodothyronine	223-225	insulin-like growth factor II	Ovis aries	53-59
9601064-0	1998	Effect of tri-iodothyronine on leptin release and leptin mRNA accumulation in rat adipose tissue.	Triiodothyronine	10-27	leptin	Rattus norvegicus	31-37
9661620-0	1998	Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes.	Triiodothyronine	62-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-58
9601064-3	1998	The administration of tri-iodothyronine (T3) 8 h before death inhibited leptin release by adipocytes incubated for 6 or 24 h. Direct addition of T3 to pieces of adipose tissue enhanced the loss of leptin mRNA seen over 24 h in the presence of dexamethasone plus the beta3-adrenergic agonist Cl 316,243.	Triiodothyronine	41-43	leptin	Rattus norvegicus	72-78
9601064-3	1998	The administration of tri-iodothyronine (T3) 8 h before death inhibited leptin release by adipocytes incubated for 6 or 24 h. Direct addition of T3 to pieces of adipose tissue enhanced the loss of leptin mRNA seen over 24 h in the presence of dexamethasone plus the beta3-adrenergic agonist Cl 316,243.	Triiodothyronine	41-43	leptin	Rattus norvegicus	197-203
9713330-2	1998	Tri-iodothyronine (T3) is known to be involved in the regulation of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis.	Triiodothyronine	0-17	insulin-like growth factor 1	Rattus norvegicus	92-120
9713330-2	1998	Tri-iodothyronine (T3) is known to be involved in the regulation of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis.	Triiodothyronine	0-17	insulin-like growth factor 1	Rattus norvegicus	122-127
9713330-2	1998	Tri-iodothyronine (T3) is known to be involved in the regulation of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis.	Triiodothyronine	19-21	insulin-like growth factor 1	Rattus norvegicus	92-120
9713330-2	1998	Tri-iodothyronine (T3) is known to be involved in the regulation of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis.	Triiodothyronine	19-21	insulin-like growth factor 1	Rattus norvegicus	122-127
9710812-5	1998	A 72-h treatment with exogenous triiodothyronine (T3, 0.1 microM) to cultured neonatal myocytes enhanced the expression of Kv4.2 by 73% and decreased the Kv1.4 expression by 22%.	Triiodothyronine	32-48	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	123-128
9710812-5	1998	A 72-h treatment with exogenous triiodothyronine (T3, 0.1 microM) to cultured neonatal myocytes enhanced the expression of Kv4.2 by 73% and decreased the Kv1.4 expression by 22%.	Triiodothyronine	32-48	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	154-159
9710812-5	1998	A 72-h treatment with exogenous triiodothyronine (T3, 0.1 microM) to cultured neonatal myocytes enhanced the expression of Kv4.2 by 73% and decreased the Kv1.4 expression by 22%.	Triiodothyronine	50-52	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	123-128
9710812-5	1998	A 72-h treatment with exogenous triiodothyronine (T3, 0.1 microM) to cultured neonatal myocytes enhanced the expression of Kv4.2 by 73% and decreased the Kv1.4 expression by 22%.	Triiodothyronine	50-52	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	154-159
9632703-4	1998	We now present data that suggest that the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses triiodothyronine (T3)-dependent transcriptional activation of PCP-2 in the immature Purkinje cell.	Triiodothyronine	143-159	Purkinje cell protein 2	Rattus norvegicus	205-210
9632703-4	1998	We now present data that suggest that the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses triiodothyronine (T3)-dependent transcriptional activation of PCP-2 in the immature Purkinje cell.	Triiodothyronine	161-163	Purkinje cell protein 2	Rattus norvegicus	205-210
9611151-2	1998	These analyses were performed in the context of slow-twitch type I myosin heavy-chain (MHC) expression, a 3,5,3"-triiodothyronine (T3)-regulated gene that displays varying responsiveness to T3 in the above tissues.	Triiodothyronine	106-129	major histocompatibility complex, class I, C	Homo sapiens	87-90
9611151-2	1998	These analyses were performed in the context of slow-twitch type I myosin heavy-chain (MHC) expression, a 3,5,3"-triiodothyronine (T3)-regulated gene that displays varying responsiveness to T3 in the above tissues.	Triiodothyronine	131-133	major histocompatibility complex, class I, C	Homo sapiens	87-90
9635125-2	1998	We studied the interaction of T3, glucocorticoids, all-trans retinoic acid (RA), and 9-cis retinoic acid (9cRA) on the expression of the rat alpha 1-acid glycoprotein (AGP) gene in vitro.	Triiodothyronine	30-32	orosomucoid 1	Rattus norvegicus	141-166
9601064-3	1998	The administration of tri-iodothyronine (T3) 8 h before death inhibited leptin release by adipocytes incubated for 6 or 24 h. Direct addition of T3 to pieces of adipose tissue enhanced the loss of leptin mRNA seen over 24 h in the presence of dexamethasone plus the beta3-adrenergic agonist Cl 316,243.	Triiodothyronine	22-39	leptin	Rattus norvegicus	72-78
9601064-3	1998	The administration of tri-iodothyronine (T3) 8 h before death inhibited leptin release by adipocytes incubated for 6 or 24 h. Direct addition of T3 to pieces of adipose tissue enhanced the loss of leptin mRNA seen over 24 h in the presence of dexamethasone plus the beta3-adrenergic agonist Cl 316,243.	Triiodothyronine	22-39	leptin	Rattus norvegicus	197-203
9653548-6	1998	The compound, GC-1, was initially designed to solve synthetic problems that limit thyroid hormone analog preparation, and contains several structural changes with respect to the natural hormone 3,5,3"-triiodo-L-thyronine (T3).	Triiodothyronine	194-220	olfactomedin 4	Homo sapiens	14-18
9653548-6	1998	The compound, GC-1, was initially designed to solve synthetic problems that limit thyroid hormone analog preparation, and contains several structural changes with respect to the natural hormone 3,5,3"-triiodo-L-thyronine (T3).	Triiodothyronine	222-224	olfactomedin 4	Homo sapiens	14-18
9486151-2	1998	Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period.	Triiodothyronine	52-68	renin	Rattus norvegicus	96-101
9556133-0	1998	Interaction of triiodothyronine with 1alpha,25-dihydroxyvitamin D3 on interleukin-6-dependent osteoclast-like cell formation in mouse bone marrow cell cultures.	Triiodothyronine	15-31	interleukin 6	Mus musculus	70-83
9749801-4	1998	After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary.	Triiodothyronine	21-37	thyrotropin-releasing hormone degrading enzyme	Rattus norvegicus	89-95
9749801-4	1998	After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary.	Triiodothyronine	21-37	thyrotropin releasing hormone	Rattus norvegicus	89-92
9749801-4	1998	After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary.	Triiodothyronine	39-41	thyrotropin-releasing hormone degrading enzyme	Rattus norvegicus	89-95
9749801-4	1998	After treatment with triiodothyronine (T3) a dramatic increase in the mRNA levels of the TRH-DE and a decrease in the intensity of the TRH receptor could be observed in the anterior lobe of the pituitary.	Triiodothyronine	39-41	thyrotropin releasing hormone	Rattus norvegicus	89-92
9524193-0	1998	1,25-Dihydroxy vitamin D3 and tri-iodothyronine stimulate the expression of a protein immunologically related to osteocalcin.	Triiodothyronine	30-47	bone gamma-carboxyglutamate protein 2	Mus musculus	113-124
9524193-3	1998	We investigated the effect of 1, 25-dihydroxy vitamin D3 (D3) and tri-iodothyronine (T3) on OC expression in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	66-83	bone gamma-carboxyglutamate protein 2	Mus musculus	92-94
9524193-3	1998	We investigated the effect of 1, 25-dihydroxy vitamin D3 (D3) and tri-iodothyronine (T3) on OC expression in osteoblast-like MC3T3-E1 cells.	Triiodothyronine	85-87	bone gamma-carboxyglutamate protein 2	Mus musculus	92-94
9530133-3	1998	In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME.	Triiodothyronine	19-35	fatty acid synthase	Gallus gallus	114-117
9669291-2	1998	Furthermore, triiodothyronine T3, at a physiological free concentration, decreases the CAI concentration in both human erythroleukemic YN-1 cells and burst-forming unit-erythroid (BFU-E)-derived cells.	Triiodothyronine	13-32	carbonic anhydrase 1	Homo sapiens	87-90
9589637-7	1998	T3-binding studies showed that the association constant of serum albumin in affected subjects was 1.5 x 10(6) M-1 or 40-fold that of unaffected relatives of 3.9 x 10(4) M-1.	Triiodothyronine	0-2	albumin	Homo sapiens	59-72
9492065-0	1998	Triiodothyronine modulates interleukin-6 synthesis in osteoblasts: inhibitions in protein kinase A and C pathways.	Triiodothyronine	0-16	interleukin 6	Mus musculus	27-40
9486151-2	1998	Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period.	Triiodothyronine	52-68	renin	Rattus norvegicus	146-151
9486151-2	1998	Despite a lack of immediate effect, incubation with triiodothyronine dose dependently increased renin secretion during the first 6 h and elevated renin content and renin mRNA levels during the subsequent period.	Triiodothyronine	52-68	renin	Rattus norvegicus	146-151
9486151-3	1998	Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels.	Triiodothyronine	29-45	renin	Rattus norvegicus	106-111
9486151-3	1998	Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels.	Triiodothyronine	29-45	renin	Rattus norvegicus	153-158
9486151-3	1998	Simultaneous incubation with triiodothyronine and the calcium ionophore A-23187 abolished the increase in renin secretion and attenuated the increase in renin content but did not affect the increase in renin mRNA levels.	Triiodothyronine	29-45	renin	Rattus norvegicus	153-158
9486151-4	1998	During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion.	Triiodothyronine	36-52	renin	Rattus norvegicus	180-185
9486151-4	1998	During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion.	Triiodothyronine	36-52	renin	Rattus norvegicus	346-351
9486151-4	1998	During simultaneous incubation with triiodothyronine and the adenylate cyclase inhibitor SQ-22536 or membrane-soluble guanosine 3",5"-cyclic monophosphate (cGMP), the increases in renin secretion, content, and mRNA were similar to those observed in the presence of triiodothyronine alone, except for a cGMP-induced attenuation of the increase in renin secretion.	Triiodothyronine	265-281	renin	Rattus norvegicus	180-185
9463486-8	1998	Expressed hST1B2 sulfates small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3"-diiodothyronine, triiodothyronine, reverse triiodothyronine, and thyroxine.	Triiodothyronine	131-147	sulfotransferase family 1B member 1	Homo sapiens	10-16
9608677-0	1998	Nocturnal increases in the triiodothyronine/thyroxine ratio in the rat thymus and pineal gland follow increases of type II 5"-deiodinase activity.	Triiodothyronine	27-43	iodothyronine deiodinase 2	Rattus norvegicus	115-136
9463486-8	1998	Expressed hST1B2 sulfates small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3"-diiodothyronine, triiodothyronine, reverse triiodothyronine, and thyroxine.	Triiodothyronine	157-173	sulfotransferase family 1B member 1	Homo sapiens	10-16
9475179-1	1998	The rat growth hormone (GH) promoter was significantly activated in non-pituitary cells by the expression of unliganded trioodothyronine (T3) and retinoic acid (RA) receptors.	Triiodothyronine	138-140	gonadotropin releasing hormone receptor	Rattus norvegicus	8-22
9605512-5	1998	Supporting the effectiveness of TRbeta gene deletion was the finding that the thiiodothyronine (T3) nuclear binding capacity in the livers and brains of knockout animals was consistent with the fractional contribution of TRbeta1 to total binding capacity in the wild-type tissues.	Triiodothyronine	96-98	apoptosis antagonizing transcription factor	Mus musculus	32-38
9475179-1	1998	The rat growth hormone (GH) promoter was significantly activated in non-pituitary cells by the expression of unliganded trioodothyronine (T3) and retinoic acid (RA) receptors.	Triiodothyronine	138-140	gonadotropin releasing hormone receptor	Rattus norvegicus	24-26
9461315-0	1998	Increased transforming growth factor-beta1 plasma concentration is associated with high plasma 3,3",5"-tri-iodothyronine in elderly patients with nonthyroidal illnesses.	Triiodothyronine	95-120	transforming growth factor beta 1	Homo sapiens	10-42
9618057-3	1998	The plasma concentrations of thyroxine and triiodothyronine increased in sows treated with TRH.	Triiodothyronine	43-59	thyrotropin releasing hormone	Sus scrofa	91-94
9817979-9	1998	17beta-estradiol and L-triiodothyronine were found to upregulate EGF-R expression, proliferative potential and SCC production in the CaSki cervical carcinoma cells.	Triiodothyronine	21-39	epidermal growth factor receptor	Homo sapiens	65-70
9817979-9	1998	17beta-estradiol and L-triiodothyronine were found to upregulate EGF-R expression, proliferative potential and SCC production in the CaSki cervical carcinoma cells.	Triiodothyronine	21-39	serpin family B member 3	Homo sapiens	111-114
9428725-3	1997	In this report we show the increase in the downstream transcript, the peroxisomal SPT (SPTp) mRNA, caused by peroxisome proliferators and triiodothyronine (T3).	Triiodothyronine	138-154	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	82-85
9551251-0	1997	Interaction between triiodothyronine and ovarian steroid hormones on the regulation of the release of thyrotropin and thyrotropin-releasing hormone in vitro.	Triiodothyronine	20-36	thyrotropin releasing hormone	Rattus norvegicus	118-147
9551251-1	1997	In vivo and in vitro experiments were designed to examine [1] the effect of triiodothyronine (T3) and/or ovarian steroids on the spontaneous and thyrotropin-releasing hormone (TRH)-stimulated release of thyrotropin (TSH) by the anterior pituitary gland (AP) in vitro; and [2] the in vivo effects of T3 and ovarian steroids on TRH-release in vitro.	Triiodothyronine	76-92	thyrotropin releasing hormone	Rattus norvegicus	176-179
9551251-1	1997	In vivo and in vitro experiments were designed to examine [1] the effect of triiodothyronine (T3) and/or ovarian steroids on the spontaneous and thyrotropin-releasing hormone (TRH)-stimulated release of thyrotropin (TSH) by the anterior pituitary gland (AP) in vitro; and [2] the in vivo effects of T3 and ovarian steroids on TRH-release in vitro.	Triiodothyronine	94-96	thyrotropin releasing hormone	Rattus norvegicus	176-179
9551251-8	1997	Application of T3 in vitro prevented the release of TSH in response to TRH.	Triiodothyronine	15-17	thyrotropin releasing hormone	Rattus norvegicus	71-74
9428725-3	1997	In this report we show the increase in the downstream transcript, the peroxisomal SPT (SPTp) mRNA, caused by peroxisome proliferators and triiodothyronine (T3).	Triiodothyronine	138-154	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	87-91
9428725-3	1997	In this report we show the increase in the downstream transcript, the peroxisomal SPT (SPTp) mRNA, caused by peroxisome proliferators and triiodothyronine (T3).	Triiodothyronine	156-158	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	82-85
9428725-3	1997	In this report we show the increase in the downstream transcript, the peroxisomal SPT (SPTp) mRNA, caused by peroxisome proliferators and triiodothyronine (T3).	Triiodothyronine	156-158	alanine--glyoxylate and serine--pyruvate aminotransferase	Rattus norvegicus	87-91
9428737-2	1997	To assess the functional modulation of UCP2 gene expression in relation to body weight control, we examined the effects of hyperthyroid state induced by chronic treatment with triiodothyronine (T3) on UCP2 mRNA expression in male rats.	Triiodothyronine	176-192	uncoupling protein 2	Rattus norvegicus	201-205
9428737-2	1997	To assess the functional modulation of UCP2 gene expression in relation to body weight control, we examined the effects of hyperthyroid state induced by chronic treatment with triiodothyronine (T3) on UCP2 mRNA expression in male rats.	Triiodothyronine	194-196	uncoupling protein 2	Rattus norvegicus	201-205
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	58-74	thyroglobulin	Homo sapiens	0-13
9367914-18	1997	Expression of rat UCP3 mRNA in BAT was upregulated by in vivo treatment with triiodothyronine (T3) and by exposure to cold, suggesting that UCP3 is active in thermogenesis and energy expenditure.	Triiodothyronine	77-93	uncoupling protein 3	Rattus norvegicus	18-22
9367914-18	1997	Expression of rat UCP3 mRNA in BAT was upregulated by in vivo treatment with triiodothyronine (T3) and by exposure to cold, suggesting that UCP3 is active in thermogenesis and energy expenditure.	Triiodothyronine	77-93	uncoupling protein 3	Rattus norvegicus	140-144
9367914-18	1997	Expression of rat UCP3 mRNA in BAT was upregulated by in vivo treatment with triiodothyronine (T3) and by exposure to cold, suggesting that UCP3 is active in thermogenesis and energy expenditure.	Triiodothyronine	95-97	uncoupling protein 3	Rattus norvegicus	18-22
9367914-18	1997	Expression of rat UCP3 mRNA in BAT was upregulated by in vivo treatment with triiodothyronine (T3) and by exposure to cold, suggesting that UCP3 is active in thermogenesis and energy expenditure.	Triiodothyronine	95-97	uncoupling protein 3	Rattus norvegicus	140-144
9351883-0	1997	Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.	Triiodothyronine	0-16	LOC102641229	Mus musculus	77-87
9351883-0	1997	Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.	Triiodothyronine	0-16	FBJ osteosarcoma oncogene	Mus musculus	104-109
9351883-0	1997	Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.	Triiodothyronine	0-16	jun proto-oncogene	Mus musculus	110-115
9351883-0	1997	Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.	Triiodothyronine	0-16	bone gamma-carboxyglutamate protein 2	Mus musculus	134-145
9414120-2	1997	Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues.	Triiodothyronine	0-16	uncoupling protein 2	Rattus norvegicus	76-80
9414120-2	1997	Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues.	Triiodothyronine	18-20	uncoupling protein 2	Rattus norvegicus	76-80
9348244-3	1997	After 6-h of incubation in treated cells, dexamethasone(Dex) and triiodo-L-thyronine(T3) significantly increased GH pre-mRNA levels(3.2- and 2.2-fold compared to non-treated cells, respectively).	Triiodothyronine	65-84	gonadotropin releasing hormone receptor	Rattus norvegicus	113-115
9348244-3	1997	After 6-h of incubation in treated cells, dexamethasone(Dex) and triiodo-L-thyronine(T3) significantly increased GH pre-mRNA levels(3.2- and 2.2-fold compared to non-treated cells, respectively).	Triiodothyronine	85-87	gonadotropin releasing hormone receptor	Rattus norvegicus	113-115
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	58-74	thyroglobulin	Homo sapiens	15-17
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	76-78	thyroglobulin	Homo sapiens	0-13
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	76-78	thyroglobulin	Homo sapiens	15-17
9347411-1	1997	OBJECTIVE: To elucidate whether the administration of small doses of triidothyronine (T3) can increase concentrations of sex hormone binding globulin (SHBG) in obese women with different types of obesity and to evaluate the potential metabolic benefits of such treatment.	Triiodothyronine	86-88	sex hormone binding globulin	Homo sapiens	121-149
9346922-1	1997	Triiodothyronine (T3) activates rat liver S14 gene transcription through T3 receptors (TRbeta) binding distal thyroid hormone response elements located between -2.8 and -2.5 kilobase pairs upstream from the transcription start site.	Triiodothyronine	0-16	thyroid hormone responsive	Rattus norvegicus	42-45
9346922-1	1997	Triiodothyronine (T3) activates rat liver S14 gene transcription through T3 receptors (TRbeta) binding distal thyroid hormone response elements located between -2.8 and -2.5 kilobase pairs upstream from the transcription start site.	Triiodothyronine	0-16	thyroid hormone receptor beta	Rattus norvegicus	87-93
9346922-1	1997	Triiodothyronine (T3) activates rat liver S14 gene transcription through T3 receptors (TRbeta) binding distal thyroid hormone response elements located between -2.8 and -2.5 kilobase pairs upstream from the transcription start site.	Triiodothyronine	18-20	thyroid hormone responsive	Rattus norvegicus	42-45
9346922-1	1997	Triiodothyronine (T3) activates rat liver S14 gene transcription through T3 receptors (TRbeta) binding distal thyroid hormone response elements located between -2.8 and -2.5 kilobase pairs upstream from the transcription start site.	Triiodothyronine	18-20	thyroid hormone receptor beta	Rattus norvegicus	87-93
9357766-3	1997	L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide.	Triiodothyronine	45-47	interferon gamma	Homo sapiens	99-108
9368511-1	1997	We have shown previously that tri-iodothyronine (T3)-induced sex hormone-binding globulin (SHBG) secretion by the human hepatoblastoma cell line, HepG2, can be modulated by retinoids.	Triiodothyronine	30-47	sex hormone binding globulin	Homo sapiens	61-89
9368511-1	1997	We have shown previously that tri-iodothyronine (T3)-induced sex hormone-binding globulin (SHBG) secretion by the human hepatoblastoma cell line, HepG2, can be modulated by retinoids.	Triiodothyronine	30-47	sex hormone binding globulin	Homo sapiens	91-95
9368511-1	1997	We have shown previously that tri-iodothyronine (T3)-induced sex hormone-binding globulin (SHBG) secretion by the human hepatoblastoma cell line, HepG2, can be modulated by retinoids.	Triiodothyronine	49-51	sex hormone binding globulin	Homo sapiens	61-89
9368511-1	1997	We have shown previously that tri-iodothyronine (T3)-induced sex hormone-binding globulin (SHBG) secretion by the human hepatoblastoma cell line, HepG2, can be modulated by retinoids.	Triiodothyronine	49-51	sex hormone binding globulin	Homo sapiens	91-95
9368511-8	1997	Conversely, 0-100 nmol/l insulin reduced SHBG production induced by 10 nmol/l T3.	Triiodothyronine	78-80	insulin	Homo sapiens	25-32
9368511-8	1997	Conversely, 0-100 nmol/l insulin reduced SHBG production induced by 10 nmol/l T3.	Triiodothyronine	78-80	sex hormone binding globulin	Homo sapiens	41-45
9328325-7	1997	In transfected HepG2 cells, taurocholate (100 micromol/L) stimulated and triiodothyronine (1 micromol/L) inhibited OATP promoter activity, whereas hydrocortisone, dexamethasone, beta-estradiol, estrone-3-sulfate, and testosterone had no significant effect.	Triiodothyronine	73-89	solute carrier organic anion transporter family member 1A2	Homo sapiens	115-119
9387861-7	1997	A single administration of triiodothyronine (T3) induced a significant transcriptional increase of RC3 mRNA in hypothyroid rats, 24 h after administration.	Triiodothyronine	27-43	neurogranin	Rattus norvegicus	99-102
9387861-7	1997	A single administration of triiodothyronine (T3) induced a significant transcriptional increase of RC3 mRNA in hypothyroid rats, 24 h after administration.	Triiodothyronine	45-47	neurogranin	Rattus norvegicus	99-102
9347411-1	1997	OBJECTIVE: To elucidate whether the administration of small doses of triidothyronine (T3) can increase concentrations of sex hormone binding globulin (SHBG) in obese women with different types of obesity and to evaluate the potential metabolic benefits of such treatment.	Triiodothyronine	86-88	sex hormone binding globulin	Homo sapiens	151-155
9349582-4	1997	In vitro transcription and translation of this mutant TRbeta demonstrated a 12-fold reduction of the affinity for triiodothyronine (T3) compared with the wild type TRbeta.	Triiodothyronine	114-130	T cell receptor beta locus	Homo sapiens	54-60
9390004-6	1997	In experiments designed to alter the thyroid hormone status in animals it was demonstrated that both the reporter gene and the endogenous CRABP-I expression were reduced by triiodothyronine injection and were elevated in a hypothyroidic condition induced by feeding with iodine-deficient diet supplemented with 6-propyl-2-thiouracil.	Triiodothyronine	173-189	cellular retinoic acid binding protein I	Mus musculus	138-145
9349585-1	1997	Highly purified human chorionic gonadotropin (hCG) interacts with the thyrotropin (TSH) receptor and stimulates triiodothyronine (T3) secretion, iodide uptake and organification, and cyclic adenosine monophosphate (cAMP) formation in human thyroid follicles.	Triiodothyronine	112-128	thyroid stimulating hormone receptor	Homo sapiens	22-96
9381511-6	1997	Triiodothyronine treatment at the most effective concentration (50 nM) increased ER and ER mRNA levels twofold.	Triiodothyronine	0-16	estrogen receptor 1	Rattus norvegicus	81-83
9381511-6	1997	Triiodothyronine treatment at the most effective concentration (50 nM) increased ER and ER mRNA levels twofold.	Triiodothyronine	0-16	estrogen receptor 1	Rattus norvegicus	88-90
9349585-1	1997	Highly purified human chorionic gonadotropin (hCG) interacts with the thyrotropin (TSH) receptor and stimulates triiodothyronine (T3) secretion, iodide uptake and organification, and cyclic adenosine monophosphate (cAMP) formation in human thyroid follicles.	Triiodothyronine	130-132	thyroid stimulating hormone receptor	Homo sapiens	22-96
9349582-4	1997	In vitro transcription and translation of this mutant TRbeta demonstrated a 12-fold reduction of the affinity for triiodothyronine (T3) compared with the wild type TRbeta.	Triiodothyronine	132-134	T cell receptor beta locus	Homo sapiens	54-60
9282911-1	1997	The calmodulin-binding, protein kinase C substrate RC3/neurogranin is the product of a neuron-specific gene expressed in the forebrain that is under specific regional and temporal control by thyroid hormone (3,5,3"-triiodothyronine, T3).	Triiodothyronine	208-231	neurogranin	Mus musculus	51-54
9282911-1	1997	The calmodulin-binding, protein kinase C substrate RC3/neurogranin is the product of a neuron-specific gene expressed in the forebrain that is under specific regional and temporal control by thyroid hormone (3,5,3"-triiodothyronine, T3).	Triiodothyronine	208-231	neurogranin	Mus musculus	55-66
9282911-1	1997	The calmodulin-binding, protein kinase C substrate RC3/neurogranin is the product of a neuron-specific gene expressed in the forebrain that is under specific regional and temporal control by thyroid hormone (3,5,3"-triiodothyronine, T3).	Triiodothyronine	233-235	neurogranin	Mus musculus	51-54
9282911-1	1997	The calmodulin-binding, protein kinase C substrate RC3/neurogranin is the product of a neuron-specific gene expressed in the forebrain that is under specific regional and temporal control by thyroid hormone (3,5,3"-triiodothyronine, T3).	Triiodothyronine	233-235	neurogranin	Mus musculus	55-66
9271365-3	1997	We analyzed how thyroid hormone (3, 5, 3"-triiodothyronine, T3), the orchestrator of metamorphosis, affects expression and function of the proapoptotic gene Bax in the tail muscle of free-living Xenopus tadpoles.	Triiodothyronine	33-58	BCL2-associated X protein S homeolog	Xenopus laevis	157-160
9277376-1	1997	This study was undertaken to investigate the effect of triiodothyronine (T3) administration to euthyroid rats on beta 3-adrenoceptor (beta 3-AR) expression and on the different components of the adenylyl cyclase (AC) system in brown adipose tissue (BAT).	Triiodothyronine	55-71	adrenoceptor beta 3	Rattus norvegicus	113-132
9277376-1	1997	This study was undertaken to investigate the effect of triiodothyronine (T3) administration to euthyroid rats on beta 3-adrenoceptor (beta 3-AR) expression and on the different components of the adenylyl cyclase (AC) system in brown adipose tissue (BAT).	Triiodothyronine	55-71	adrenoceptor beta 3	Rattus norvegicus	134-143
9277376-1	1997	This study was undertaken to investigate the effect of triiodothyronine (T3) administration to euthyroid rats on beta 3-adrenoceptor (beta 3-AR) expression and on the different components of the adenylyl cyclase (AC) system in brown adipose tissue (BAT).	Triiodothyronine	73-75	adrenoceptor beta 3	Rattus norvegicus	113-132
9277376-1	1997	This study was undertaken to investigate the effect of triiodothyronine (T3) administration to euthyroid rats on beta 3-adrenoceptor (beta 3-AR) expression and on the different components of the adenylyl cyclase (AC) system in brown adipose tissue (BAT).	Triiodothyronine	73-75	adrenoceptor beta 3	Rattus norvegicus	134-143
9291833-0	1997	Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells.	Triiodothyronine	12-29	endothelin 1	Homo sapiens	33-45
9291833-0	1997	Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells.	Triiodothyronine	12-29	fibronectin 1	Homo sapiens	47-58
9291833-0	1997	Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells.	Triiodothyronine	12-29	von Willebrand factor	Homo sapiens	63-84
9271365-3	1997	We analyzed how thyroid hormone (3, 5, 3"-triiodothyronine, T3), the orchestrator of metamorphosis, affects expression and function of the proapoptotic gene Bax in the tail muscle of free-living Xenopus tadpoles.	Triiodothyronine	60-62	BCL2-associated X protein S homeolog	Xenopus laevis	157-160
9202038-3	1997	Following 3,5, 3"-triiodo-L-thyronine (T3) stimulation in vivo, there is a gradual increase in the amount of UGT1A1 mRNA with maximum levels reached 24 h after treatment.	Triiodothyronine	10-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
9202038-3	1997	Following 3,5, 3"-triiodo-L-thyronine (T3) stimulation in vivo, there is a gradual increase in the amount of UGT1A1 mRNA with maximum levels reached 24 h after treatment.	Triiodothyronine	39-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
9078584-5	1997	Estradiol and triiodothyronine but not testosterone increased significantly (p < 0.05 vs. control) the secretion of SHBG into the culture media.	Triiodothyronine	14-30	sex hormone binding globulin	Homo sapiens	119-123
9220146-2	1997	In particular: a) intrathymic transplant of pineal gland or treatment with melatonin; b) implantation of a growth hormone secreting tumor cell line or treatment with exogenous growth hormone; c) castration or treatment with exogenous LH-RH; d) treatment with exogenous thyroxine or triiodothyronine, and e) nutritional interventions such as arginine or zinc supplementation.	Triiodothyronine	282-298	gonadotropin releasing hormone 1	Homo sapiens	234-239
9177398-0	1997	Triiodothyronine and follicle-stimulating hormone, alone and additively together, stimulate production of the tissue inhibitor of metalloproteinases-1 in cultured human luteinized granulosa cells.	Triiodothyronine	0-16	TIMP metallopeptidase inhibitor 1	Homo sapiens	110-150
9256366-1	1997	Previous studies in our laboratory show that triiodothyronine upregulates expression of the cerebellar Purkinje cell-specific gene Pcp-2 during the first 2 weeks of rat neonatal life.	Triiodothyronine	45-61	Purkinje cell protein 2	Rattus norvegicus	131-136
9220022-0	1997	Effects of triiodothyronine and retinoic acid on glucokinase gene expression in neonatal rat hepatocytes.	Triiodothyronine	11-27	glucokinase	Rattus norvegicus	49-60
9220022-6	1997	This suggests that triiodothyronine and retinoic acid act on glucokinase gene at the transcriptional.	Triiodothyronine	19-35	glucokinase	Rattus norvegicus	61-72
9162076-4	1997	The betaTP gene promoter is responsive to thyroid hormone (3,3",5-triiodothyronine, T3) and efficiently repressed by unliganded human thyroid hormone receptor beta (TRbeta).	Triiodothyronine	59-82	prostaglandin D2 synthase	Homo sapiens	4-10
9162076-4	1997	The betaTP gene promoter is responsive to thyroid hormone (3,3",5-triiodothyronine, T3) and efficiently repressed by unliganded human thyroid hormone receptor beta (TRbeta).	Triiodothyronine	84-86	prostaglandin D2 synthase	Homo sapiens	4-10
9129466-7	1997	GH significantly decreased serum total triiodothyronine concentrations and IGF-I significantly decreased serum corticosterone concentrations.	Triiodothyronine	39-55	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
9168944-2	1997	Daily injections of 15 micrograms triiodothyronine (T3)/100 g body weight to hypothyroid mice resulted in repression of SCD1 mRNA levels by more than 50% in 48 hours and up to 65% in 6 days.	Triiodothyronine	34-50	stearoyl-Coenzyme A desaturase 1	Mus musculus	120-124
9168944-2	1997	Daily injections of 15 micrograms triiodothyronine (T3)/100 g body weight to hypothyroid mice resulted in repression of SCD1 mRNA levels by more than 50% in 48 hours and up to 65% in 6 days.	Triiodothyronine	52-54	stearoyl-Coenzyme A desaturase 1	Mus musculus	120-124
9048629-1	1997	Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle.	Triiodothyronine	57-59	solute carrier family 2 member 4	Rattus norvegicus	72-110
9100577-9	1997	TR beta-EZ had a strong dominant negative effect on TR beta-WT, attenuated in a TRE- and cell-specific manner by high T3 concentrations.	Triiodothyronine	118-120	T cell receptor alpha locus	Homo sapiens	0-7
9100577-9	1997	TR beta-EZ had a strong dominant negative effect on TR beta-WT, attenuated in a TRE- and cell-specific manner by high T3 concentrations.	Triiodothyronine	118-120	T cell receptor alpha locus	Homo sapiens	52-59
9126361-4	1997	After a 24-h incubation, triiodothyronine (T3) at 10-1000 nmol/l significantly increased the expression of leptin mRNA (237-337%).	Triiodothyronine	25-41	leptin	Homo sapiens	107-113
9126361-4	1997	After a 24-h incubation, triiodothyronine (T3) at 10-1000 nmol/l significantly increased the expression of leptin mRNA (237-337%).	Triiodothyronine	43-45	leptin	Homo sapiens	107-113
9540232-0	1997	Regulation of IGFBP-1 and -4 expression by triiodothyronine (T3) in cultured hepatocytes is cell- and gene-specific.	Triiodothyronine	43-59	insulin like growth factor binding protein 1	Homo sapiens	14-28
9540232-0	1997	Regulation of IGFBP-1 and -4 expression by triiodothyronine (T3) in cultured hepatocytes is cell- and gene-specific.	Triiodothyronine	61-63	insulin like growth factor binding protein 1	Homo sapiens	14-28
9225129-3	1997	Hormones and neurotransmitters, including thyroid hormone (T3), glucocorticoids, testosterone, and 5-HT initiate effects not only in the cardiovascular system, but also in the regulation of hypothalamic TRH.	Triiodothyronine	59-61	thyrotropin releasing hormone	Rattus norvegicus	203-206
9328213-0	1997	Up-regulation of the estrogen receptor by triiodothyronine in rat pituitary cell lines.	Triiodothyronine	42-58	estrogen receptor 1	Rattus norvegicus	21-38
9111526-1	1997	We studied the time course of cell surface beta-adrenoceptors (BAR) in cardiomyocytes in response to a single triiodothyronine (T3) (10(-8) M) stimulation.	Triiodothyronine	110-126	adrenoceptor beta 2	Homo sapiens	63-66
9111526-1	1997	We studied the time course of cell surface beta-adrenoceptors (BAR) in cardiomyocytes in response to a single triiodothyronine (T3) (10(-8) M) stimulation.	Triiodothyronine	128-130	adrenoceptor beta 2	Homo sapiens	63-66
9048629-1	1997	Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle.	Triiodothyronine	57-59	solute carrier family 2 member 4	Rattus norvegicus	112-117
9071962-0	1997	Tri-iodothyronine prevents the amiodarone-induced decrease in the expression of the liver low-density lipoprotein receptor gene.	Triiodothyronine	0-17	low density lipoprotein receptor	Rattus norvegicus	90-122
9078282-1	1997	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by cAMP, the thyroid hormone tri-iodothyronine (T3) and retinoic acid (RA).	Triiodothyronine	115-132	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	30-63
9078282-1	1997	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by cAMP, the thyroid hormone tri-iodothyronine (T3) and retinoic acid (RA).	Triiodothyronine	115-132	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	65-70
9078282-1	1997	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by cAMP, the thyroid hormone tri-iodothyronine (T3) and retinoic acid (RA).	Triiodothyronine	134-136	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	30-63
9078282-1	1997	Transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK) is stimulated by cAMP, the thyroid hormone tri-iodothyronine (T3) and retinoic acid (RA).	Triiodothyronine	134-136	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	65-70
9028477-0	1997	Alterations in specific activity of glucose-6-phosphatase in laboratory rats after leptospiral exposure followed by triiodothyronine administration.	Triiodothyronine	116-132	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	36-57
9070250-7	1997	A receptor-saturating dose of thyroid hormone, triiodothyronine, repressed vitamin A-elevated SCD1 mRNA levels in vivo.	Triiodothyronine	47-63	stearoyl-Coenzyme A desaturase 1	Mus musculus	94-98
9027554-2	1997	We cultured pig preadipocytes for 10 d and studied the effects of insulin, hydrocortisone, and triiodothyronine (T3) added to serum-free basal medium on differentiation and gene expression of lipoprotein lipase an early marker, and adipsin, a late marker of preadipocyte differentiation.	Triiodothyronine	95-111	lipoprotein lipase	Sus scrofa	192-210
9152619-5	1997	There was a close association between the increment in serum PRL and of free triiodothyronine above the basal level after TRH administration.	Triiodothyronine	77-93	prolactin	Homo sapiens	61-64
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	22-39	leptin	Rattus norvegicus	95-101
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	22-39	leptin	Rattus norvegicus	132-138
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	22-39	leptin	Rattus norvegicus	132-138
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	22-39	adrenoceptor beta 3	Rattus norvegicus	246-272
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	41-43	leptin	Rattus norvegicus	95-101
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	41-43	leptin	Rattus norvegicus	132-138
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	41-43	leptin	Rattus norvegicus	132-138
9078254-2	1997	The administration of tri-iodothyronine (T3) to hypothyroid rats resulted in a 40% decrease in leptin mRNA at 8 h. This decrease in leptin mRNA was associated with a parallel decline in circulating leptin levels of about 50% at 24 h. Conversely, beta 3-adrenergic receptor mRNA levels were markedly decreased in epididymal adipose tissue from hypothyroid rats.	Triiodothyronine	41-43	adrenoceptor beta 3	Rattus norvegicus	246-272
9016809-0	1997	Triiodothyronine stimulates and glucagon inhibits transcription of the acetyl-CoA carboxylase gene in chick embryo hepatocytes: glucose and insulin amplify the effect of triiodothyronine.	Triiodothyronine	0-16	insulin	Gallus gallus	140-147
9016809-0	1997	Triiodothyronine stimulates and glucagon inhibits transcription of the acetyl-CoA carboxylase gene in chick embryo hepatocytes: glucose and insulin amplify the effect of triiodothyronine.	Triiodothyronine	170-186	insulin	Gallus gallus	140-147
9027365-1	1997	The rat S14 gene has been a useful model to study carbohydrate and triiodothyronine (T3) regulation of hepatic gene expression.	Triiodothyronine	67-83	thyroid hormone responsive	Rattus norvegicus	8-11
9027365-1	1997	The rat S14 gene has been a useful model to study carbohydrate and triiodothyronine (T3) regulation of hepatic gene expression.	Triiodothyronine	85-87	thyroid hormone responsive	Rattus norvegicus	8-11
9000465-0	1997	Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3",5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken.	Triiodothyronine	90-116	insulin like growth factor 1	Gallus gallus	31-59
9000465-0	1997	Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3",5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken.	Triiodothyronine	90-116	growth hormone receptor	Gallus gallus	140-163
9027554-2	1997	We cultured pig preadipocytes for 10 d and studied the effects of insulin, hydrocortisone, and triiodothyronine (T3) added to serum-free basal medium on differentiation and gene expression of lipoprotein lipase an early marker, and adipsin, a late marker of preadipocyte differentiation.	Triiodothyronine	113-115	lipoprotein lipase	Sus scrofa	192-210
8981225-11	1996	Significant correlations were obtained between TNF-alpha levels and the decrease in Tg, T3 and cAMP concentrations.	Triiodothyronine	88-90	tumor necrosis factor	Homo sapiens	47-56
8973649-1	1996	Protein disulfide-isomerase (PDI), an abundant multifunctional protein, has been described as a 3,3",5-triiodo-L-thyronine (T3)-binding protein.	Triiodothyronine	96-122	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
8973649-1	1996	Protein disulfide-isomerase (PDI), an abundant multifunctional protein, has been described as a 3,3",5-triiodo-L-thyronine (T3)-binding protein.	Triiodothyronine	96-122	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
8973649-1	1996	Protein disulfide-isomerase (PDI), an abundant multifunctional protein, has been described as a 3,3",5-triiodo-L-thyronine (T3)-binding protein.	Triiodothyronine	124-126	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
8973649-1	1996	Protein disulfide-isomerase (PDI), an abundant multifunctional protein, has been described as a 3,3",5-triiodo-L-thyronine (T3)-binding protein.	Triiodothyronine	124-126	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
10979048-3	1996	On the other hand, hyperinsulinaemia and disorders in GH, PRL and cortisol release were associated with lower levels of reverse triiodothyronine, gonadotropins, testosterone, 17-corticoids and SHBG and higher levels of triiodothyronine, estradiol, 17-hydroxycorticoids and IGF-I.	Triiodothyronine	128-144	prolactin	Homo sapiens	58-61
10979048-3	1996	On the other hand, hyperinsulinaemia and disorders in GH, PRL and cortisol release were associated with lower levels of reverse triiodothyronine, gonadotropins, testosterone, 17-corticoids and SHBG and higher levels of triiodothyronine, estradiol, 17-hydroxycorticoids and IGF-I.	Triiodothyronine	219-235	prolactin	Homo sapiens	58-61
9025717-1	1996	Thyroid hormone (triiodothyronine; T3) has been shown to control the expression of beta 1-adrenergic receptors (beta 1-AR) in cardiac myocytes, but not in C6 glioma cells.	Triiodothyronine	17-33	adrenoceptor beta 1	Homo sapiens	83-110
9025717-1	1996	Thyroid hormone (triiodothyronine; T3) has been shown to control the expression of beta 1-adrenergic receptors (beta 1-AR) in cardiac myocytes, but not in C6 glioma cells.	Triiodothyronine	17-33	adrenoceptor beta 1	Homo sapiens	112-121
9025717-1	1996	Thyroid hormone (triiodothyronine; T3) has been shown to control the expression of beta 1-adrenergic receptors (beta 1-AR) in cardiac myocytes, but not in C6 glioma cells.	Triiodothyronine	35-37	adrenoceptor beta 1	Homo sapiens	83-110
9025717-1	1996	Thyroid hormone (triiodothyronine; T3) has been shown to control the expression of beta 1-adrenergic receptors (beta 1-AR) in cardiac myocytes, but not in C6 glioma cells.	Triiodothyronine	35-37	adrenoceptor beta 1	Homo sapiens	112-121
8952005-8	1996	Thyroxine and triiodothyronine injected once, s.c., into hypothyroid rats required 30 min to normalize NB content, which reached higher than normal values in 3-6 h. At these times, the increment in NB preceded or was simultaneous with the suppression of serum TSH.	Triiodothyronine	14-30	neuromedin B	Rattus norvegicus	103-105
9001201-11	1996	Results of treatment with the locus coeruleus neurotoxin DSP-4 established that axonal transport accounts for delivery of both triiodothyronine and norepinephrine from locus coeruleus to noradrenergic terminal fields.	Triiodothyronine	127-143	dual specificity phosphatase 26	Homo sapiens	57-62
8952005-8	1996	Thyroxine and triiodothyronine injected once, s.c., into hypothyroid rats required 30 min to normalize NB content, which reached higher than normal values in 3-6 h. At these times, the increment in NB preceded or was simultaneous with the suppression of serum TSH.	Triiodothyronine	14-30	neuromedin B	Rattus norvegicus	198-200
8878423-0	1996	Triiodothyronine induces over-expression of alpha-smooth muscle actin, restricts myofibrillar expansion and is permissive for the action of basic fibroblast growth factor and insulin-like growth factor I in adult rat cardiomyocytes.	Triiodothyronine	0-16	actin gamma 2, smooth muscle	Rattus norvegicus	44-69
8878423-0	1996	Triiodothyronine induces over-expression of alpha-smooth muscle actin, restricts myofibrillar expansion and is permissive for the action of basic fibroblast growth factor and insulin-like growth factor I in adult rat cardiomyocytes.	Triiodothyronine	0-16	fibroblast growth factor 2	Rattus norvegicus	140-170
8878423-0	1996	Triiodothyronine induces over-expression of alpha-smooth muscle actin, restricts myofibrillar expansion and is permissive for the action of basic fibroblast growth factor and insulin-like growth factor I in adult rat cardiomyocytes.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	175-203
8884066-0	1996	A method for the determination of type I iodothyronine deiodinase activity in liver and kidney using 125I-labelled reverse triiodothyronine as a substrate.	Triiodothyronine	123-139	iodothyronine deiodinase 1	Homo sapiens	34-65
8923257-3	1996	For one herd, supplementation with Se increased the triiodothyronine response to challenge with thyrotropin-releasing hormone, increased BW gain, and tended to increase the plasma concentration of IGF-I.	Triiodothyronine	52-68	thyrotropin releasing hormone	Bos taurus	96-125
8980894-3	1996	During IFN-beta administration (4th to 8th week of treatment), both serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations decreased significantly (P < 0.0005 and P < 0.05, respectively): FT4, 1.37 +/- 0.17 to 1.09 +/- 0.12 ng/dl, and FT3, 3.71 +/- 0.45 to 3.28 +/- 0.34 pg/ml.	Triiodothyronine	104-120	interferon beta 1	Homo sapiens	7-15
8679584-1	1996	Transcription of the antiatherogenic protein apolipoprotein AI is regulated by the thyroid hormone, L-triiodothyronine.	Triiodothyronine	100-118	apolipoprotein A1	Rattus norvegicus	45-62
8792772-2	1996	The thyroid hormone triiodothryonine (T3) is known to be a potent mediator of expression of the apoA-I structural gene (APOA1).	Triiodothyronine	38-40	apolipoprotein A1	Homo sapiens	96-102
8792772-2	1996	The thyroid hormone triiodothryonine (T3) is known to be a potent mediator of expression of the apoA-I structural gene (APOA1).	Triiodothyronine	38-40	apolipoprotein A1	Homo sapiens	120-125
8754738-8	1996	With T3 (10 nM) together with RA (3, 10, or 100 nM), the maximal SHBG responses were reduced to 193 +/- 24%, 151 +/- 5% and 132 +/- 30%, respectively.	Triiodothyronine	5-7	sex hormone binding globulin	Homo sapiens	65-69
8662980-9	1996	We observed that the addition of triiodothyronine-bound recombinant TRbeta or a ligand binding domain (LBD) peptide(145-456) inhibited specifically transcriptional activation of a progesterone-responsive gene by endogenous PRs in nuclear extracts of T47D cells, while the basal level of transcription from a minimal TATA-promoter or transcription from an adenovirus major-late promoter remained unaffected.	Triiodothyronine	33-49	T cell receptor beta locus	Homo sapiens	68-74
8662980-11	1996	This concept was reinforced by biochemical evidence that treatment of T47D extracts with immobilized TRbeta LBD depleted the extract of the coactivator function in a triiodothyronine-dependent manner and markedly impaired progesterone-induced transactivation of progesterone response element-linked genes.	Triiodothyronine	166-182	T cell receptor beta locus	Homo sapiens	101-107
8884785-8	1996	(4) Unlike that in noradrenergic target cells, triiodothyronine staining was decidedly perikaryal in locus coeruleus (A-6) and the other A-1 to A-7 cell groups; the staining pattern in locus coeruleus cytosol and processes was heavy, clumped and similar to that seen in contiguous sections immunostained for tyrosine hydroxylase.	Triiodothyronine	47-63	immunoglobulin kappa variable 3D-25 (pseudogene)	Homo sapiens	118-121
8884785-8	1996	(4) Unlike that in noradrenergic target cells, triiodothyronine staining was decidedly perikaryal in locus coeruleus (A-6) and the other A-1 to A-7 cell groups; the staining pattern in locus coeruleus cytosol and processes was heavy, clumped and similar to that seen in contiguous sections immunostained for tyrosine hydroxylase.	Triiodothyronine	47-63	immunoglobulin kappa variable 2D-24 (non-functional)	Homo sapiens	144-147
8761481-4	1996	Stimulation of the hepatoma cell line HepG2 with the receptor ligands L-3,5,3"-tri-iodothyronine, all-trans retinoic acid, or their combination, increased production of antithrombin into the culture medium by 1.3-, 1.6-, and 2.0-fold, respectively.	Triiodothyronine	70-96	serpin family C member 1	Homo sapiens	169-181
8769362-2	1996	Furthermore, the possible linkage between the well-known GH-induced increase in peripheral thyroxine (T4) to triiodothyronine (T3) generation and the effects of GH on lipid and lipoprotein metabolism has not been elucidated.	Triiodothyronine	109-125	growth hormone 1	Homo sapiens	57-59
8769362-2	1996	Furthermore, the possible linkage between the well-known GH-induced increase in peripheral thyroxine (T4) to triiodothyronine (T3) generation and the effects of GH on lipid and lipoprotein metabolism has not been elucidated.	Triiodothyronine	127-129	growth hormone 1	Homo sapiens	57-59
8706762-0	1996	Triiodothyronine regulates beta 3-adrenoceptor expression in 3T3-F442A differentiating adipocytes.	Triiodothyronine	0-16	adrenergic receptor, beta 3	Mus musculus	27-46
8706762-2	1996	As assessed by molecular and pharmacological analyses, triiodothyronine addition to differentiating 3T3-F442A cells caused a 2.3-fold increase in beta 3-adrenoceptor mRNA levels, which was correlated with a parallel induction of beta 3-adrenoceptor number and of beta 3-adrenoceptor coupling to the adenylate cyclase system.	Triiodothyronine	55-71	adrenergic receptor, beta 3	Mus musculus	146-165
8706762-2	1996	As assessed by molecular and pharmacological analyses, triiodothyronine addition to differentiating 3T3-F442A cells caused a 2.3-fold increase in beta 3-adrenoceptor mRNA levels, which was correlated with a parallel induction of beta 3-adrenoceptor number and of beta 3-adrenoceptor coupling to the adenylate cyclase system.	Triiodothyronine	55-71	adrenergic receptor, beta 3	Mus musculus	229-248
8706762-2	1996	As assessed by molecular and pharmacological analyses, triiodothyronine addition to differentiating 3T3-F442A cells caused a 2.3-fold increase in beta 3-adrenoceptor mRNA levels, which was correlated with a parallel induction of beta 3-adrenoceptor number and of beta 3-adrenoceptor coupling to the adenylate cyclase system.	Triiodothyronine	55-71	adrenergic receptor, beta 3	Mus musculus	229-248
8706762-5	1996	Triiodothyronine exhibited a discrete effect on beta 3-adrenoceptor expression when added to mature 3T3-F442A adipocytes.	Triiodothyronine	0-16	adrenergic receptor, beta 3	Mus musculus	48-67
8865371-4	1996	Thyroid hormone modulates the activity of neuronal NOS; therefore, we examined whether triiodothyronine (T3) stimulated the activity of inducible iNOS in mesangial cells, LLC-PK1 cells (analogue of the proximal tubule) and MDCK cells (analogue of the distal tubule).	Triiodothyronine	87-103	nitric oxide synthase 2	Sus scrofa	146-150
8865371-4	1996	Thyroid hormone modulates the activity of neuronal NOS; therefore, we examined whether triiodothyronine (T3) stimulated the activity of inducible iNOS in mesangial cells, LLC-PK1 cells (analogue of the proximal tubule) and MDCK cells (analogue of the distal tubule).	Triiodothyronine	105-107	nitric oxide synthase 2	Sus scrofa	146-150
8814474-1	1996	OBJECTIVE: Thyroxine (T4) is deiodinated to triiodothyronine (T3) by the hepatic type I iodothyronine deiodinase, a selenoprotein that is sensitive to selenium (Se) deficiency.	Triiodothyronine	44-60	iodothyronine deiodinase 1	Homo sapiens	81-112
8662924-2	1996	Northern blot analysis revealed that there were two ZAKI-4 mRNA species (3.4 and 1.4 kilobases (kb)), and they were up-regulated by a physiological concentration of triiodothyronine (T3).	Triiodothyronine	165-181	regulator of calcineurin 2	Homo sapiens	52-58
8662924-2	1996	Northern blot analysis revealed that there were two ZAKI-4 mRNA species (3.4 and 1.4 kilobases (kb)), and they were up-regulated by a physiological concentration of triiodothyronine (T3).	Triiodothyronine	183-185	regulator of calcineurin 2	Homo sapiens	52-58
8811329-6	1996	Increased numbers of CD5+ B cells were related to the increased free thyroxine and total triiodothyronine serum levels.	Triiodothyronine	89-105	CD5 molecule	Homo sapiens	21-24
8814474-1	1996	OBJECTIVE: Thyroxine (T4) is deiodinated to triiodothyronine (T3) by the hepatic type I iodothyronine deiodinase, a selenoprotein that is sensitive to selenium (Se) deficiency.	Triiodothyronine	62-64	iodothyronine deiodinase 1	Homo sapiens	81-112
8613467-6	1996	3,3",5-L-triiodothyronine (L-T3) was as effective as L-T4 when coincubated for 24 h with IFN-gamma but was less effective than L-T4 when coincubated for only 4 h. D-T4, D-T3, 3,3",5-triiodothyroacetic acid (triac), tetraiodothyroacetic acid (tetrac), and 3,5-diiodothyronine (T2) were inactive.	Triiodothyronine	27-31	interferon gamma	Homo sapiens	89-98
8664976-2	1996	Growth hormone treatment of healthy and GH-deficient subjects is accompanied by increased conversion of thyroxine (T4) to triiodothyronine (T3) in peripheral tissues.	Triiodothyronine	122-138	growth hormone 1	Homo sapiens	0-14
8664976-2	1996	Growth hormone treatment of healthy and GH-deficient subjects is accompanied by increased conversion of thyroxine (T4) to triiodothyronine (T3) in peripheral tissues.	Triiodothyronine	140-142	growth hormone 1	Homo sapiens	0-14
8662626-2	1996	These studies demonstrate that thyroid hormone (T3) can modulate the binding activity of the IRP to an IRE in vitro and in vivo.	Triiodothyronine	48-50	Wnt family member 2	Homo sapiens	93-96
8662626-4	1996	Hepatic IRP binding to the ferritin IRE also diminished after in vivo administration of T3 with iron to rats.	Triiodothyronine	88-90	caspase 3	Rattus norvegicus	8-11
8664985-0	1996	Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells.	Triiodothyronine	10-26	estrogen receptor 1	Rattus norvegicus	45-62
8664985-2	1996	It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4- week-old euthyroid rats.	Triiodothyronine	174-190	estrogen receptor 1	Rattus norvegicus	199-216
8664985-2	1996	It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4- week-old euthyroid rats.	Triiodothyronine	192-194	estrogen receptor 1	Rattus norvegicus	199-216
8613467-10	1996	When L-T4, L-T3, or rT3, plus cycloheximide (5 micrograms/ml), was added to cells for 24 h and then removed prior to 24 h IFN-gamma exposure, the potentiating effect of the three iodothyronines was completely inhibited.	Triiodothyronine	11-15	interferon gamma	Homo sapiens	122-131
18406732-3	1996	In this review, new areas of TRH biology are explored, focused on the differential regulation of the TRH gene by triiodothyronine (T(3)) and other substances in the hypothalamus and two unexpected extrahypothalamic loci, the heart and testis.	Triiodothyronine	113-129	thyrotropin releasing hormone	Homo sapiens	29-32
8615842-6	1996	Treatment of hepatocytes with tri-iodothyronine (T3) enhanced CBG expression and, most interestingly, appeared to synergize with PACAP to elicit a 2-3-fold amplification of CBG synthesis.	Triiodothyronine	30-47	serpin family A member 6	Rattus norvegicus	62-65
8615842-6	1996	Treatment of hepatocytes with tri-iodothyronine (T3) enhanced CBG expression and, most interestingly, appeared to synergize with PACAP to elicit a 2-3-fold amplification of CBG synthesis.	Triiodothyronine	30-47	adenylate cyclase activating polypeptide 1	Rattus norvegicus	129-134
8615842-6	1996	Treatment of hepatocytes with tri-iodothyronine (T3) enhanced CBG expression and, most interestingly, appeared to synergize with PACAP to elicit a 2-3-fold amplification of CBG synthesis.	Triiodothyronine	30-47	serpin family A member 6	Rattus norvegicus	173-176
8615842-6	1996	Treatment of hepatocytes with tri-iodothyronine (T3) enhanced CBG expression and, most interestingly, appeared to synergize with PACAP to elicit a 2-3-fold amplification of CBG synthesis.	Triiodothyronine	49-51	serpin family A member 6	Rattus norvegicus	62-65
8615842-6	1996	Treatment of hepatocytes with tri-iodothyronine (T3) enhanced CBG expression and, most interestingly, appeared to synergize with PACAP to elicit a 2-3-fold amplification of CBG synthesis.	Triiodothyronine	49-51	serpin family A member 6	Rattus norvegicus	173-176
18406732-3	1996	In this review, new areas of TRH biology are explored, focused on the differential regulation of the TRH gene by triiodothyronine (T(3)) and other substances in the hypothalamus and two unexpected extrahypothalamic loci, the heart and testis.	Triiodothyronine	113-129	thyrotropin releasing hormone	Homo sapiens	101-104
18406732-3	1996	In this review, new areas of TRH biology are explored, focused on the differential regulation of the TRH gene by triiodothyronine (T(3)) and other substances in the hypothalamus and two unexpected extrahypothalamic loci, the heart and testis.	Triiodothyronine	131-135	thyrotropin releasing hormone	Homo sapiens	29-32
18406732-3	1996	In this review, new areas of TRH biology are explored, focused on the differential regulation of the TRH gene by triiodothyronine (T(3)) and other substances in the hypothalamus and two unexpected extrahypothalamic loci, the heart and testis.	Triiodothyronine	131-135	thyrotropin releasing hormone	Homo sapiens	101-104
8699429-5	1996	TRH infusion stimulated a sustained increase (P < 0.001) in plasma concentrations of thyroxine, tri-iodothyronine and prolactin (thyroxine: 158 +/- 9.3 and 65 +/- 7.7 nmol l-1 for TRH-infused and control ewes, respectively; tri-iodothyronine, 2.6 +/- 0.12 and 1.1 +/- 0.19 nmol l-1 and prolactin, 57 +/- 12 and 11 +/- 2 micrograms l-1).	Triiodothyronine	99-116	thyrotropin releasing hormone	Homo sapiens	0-3
8699429-5	1996	TRH infusion stimulated a sustained increase (P < 0.001) in plasma concentrations of thyroxine, tri-iodothyronine and prolactin (thyroxine: 158 +/- 9.3 and 65 +/- 7.7 nmol l-1 for TRH-infused and control ewes, respectively; tri-iodothyronine, 2.6 +/- 0.12 and 1.1 +/- 0.19 nmol l-1 and prolactin, 57 +/- 12 and 11 +/- 2 micrograms l-1).	Triiodothyronine	227-244	thyrotropin releasing hormone	Homo sapiens	0-3
8699429-10	1996	Thus continuous TRH infusion suppressed plasma prolactin, doubled the circulating concentrations of thyroxine and tri-iodothyronine, and was associated with a wide range of abnormalities in ovarian function and endocrine status, the nature of which varied between ewes.	Triiodothyronine	114-131	thyrotropin releasing hormone	Homo sapiens	16-19
8615842-0	1996	Pituitary adenylate cyclase-activating polypeptide induces expression of corticosteroid-binding globulin in cultured fetal hepatocytes: synergy with tri-iodothyronine.	Triiodothyronine	149-166	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
8615842-0	1996	Pituitary adenylate cyclase-activating polypeptide induces expression of corticosteroid-binding globulin in cultured fetal hepatocytes: synergy with tri-iodothyronine.	Triiodothyronine	149-166	serpin family A member 6	Rattus norvegicus	73-104
8612408-0	1996	Thyrotropin-releasing hormone in critical illness: from a dopamine-dependent test to a strategy for increasing low serum triiodothyronine, prolactin, and growth hormone concentrations.	Triiodothyronine	121-137	thyrotropin releasing hormone	Homo sapiens	0-29
8619789-2	1996	Either exogenous transforming growth factor-alpha (TGF alpha) or epidermal growth factor(EGF) prevented the cells from apoptosis in the presence of 4,5-didehydro GGA, but hepatocyte growth factor, insulin-like growth factor-II, insulin or triiodothyronine was essentially inactive.	Triiodothyronine	239-255	tumor necrosis factor	Homo sapiens	17-49
8778198-10	1996	Triiodothyronine did not change functional hepatic nitrogen clearance (36.7 +/- 3.2 l/h), but triiodothyronine given together with growth hormone abolished the effect of growth hormone functional hepatic nitrogen clearance (38.8 +/- 4.8 l/h).	Triiodothyronine	94-110	growth hormone 1	Homo sapiens	170-184
8778198-12	1996	Triiodothyronine has no effect on functional hepatic nitrogen clearance, but given together with growth hormone, it abolishes the effect of growth hormone on functional hepatic nitrogen clearance.	Triiodothyronine	0-16	growth hormone 1	Homo sapiens	140-154
8778734-6	1996	Plasma triiodothyronine (T3) concentrations were significantly depressed by IGF-II treatment.	Triiodothyronine	7-23	IGFII	Gallus gallus	76-82
8778734-6	1996	Plasma triiodothyronine (T3) concentrations were significantly depressed by IGF-II treatment.	Triiodothyronine	25-27	IGFII	Gallus gallus	76-82
8786093-2	1996	This is a novel missense mutation that resides in one of the two mutational "hot-spot" regions of the TR beta gene suggesting altered triiodothyronine binding to this mutant receptor.	Triiodothyronine	134-150	T cell receptor beta locus	Homo sapiens	102-109
8648168-8	1996	Treatment with either 10 nM dexamethasone or 10 nM triiodothyronine accelerated SC development and barrier formation by 2 d. These results indicate that (i) the late events of fetal epidermal development progress in vitro under serum- and growth factor-free conditions, culminating in the formation of a functional barrier, and (ii) both dexamethasone and triiodothyronine accelerate barrier development.	Triiodothyronine	51-67	myotrophin	Rattus norvegicus	239-252
8619789-2	1996	Either exogenous transforming growth factor-alpha (TGF alpha) or epidermal growth factor(EGF) prevented the cells from apoptosis in the presence of 4,5-didehydro GGA, but hepatocyte growth factor, insulin-like growth factor-II, insulin or triiodothyronine was essentially inactive.	Triiodothyronine	239-255	transforming growth factor alpha	Homo sapiens	51-60
8619789-2	1996	Either exogenous transforming growth factor-alpha (TGF alpha) or epidermal growth factor(EGF) prevented the cells from apoptosis in the presence of 4,5-didehydro GGA, but hepatocyte growth factor, insulin-like growth factor-II, insulin or triiodothyronine was essentially inactive.	Triiodothyronine	239-255	epidermal growth factor	Homo sapiens	89-92
8598220-0	1996	Triiodothyronine stimulates the expression of sucrase-isomaltase in Caco-2 cells cultured in serum-free medium.	Triiodothyronine	0-16	sucrase-isomaltase	Homo sapiens	46-64
8630522-0	1996	Response of triiodothyronine-dependent enzyme activities to insulin-like growth factor I and growth hormone in cultured rat hepatocytes.	Triiodothyronine	12-28	insulin-like growth factor 1	Rattus norvegicus	60-88
8630522-0	1996	Response of triiodothyronine-dependent enzyme activities to insulin-like growth factor I and growth hormone in cultured rat hepatocytes.	Triiodothyronine	12-28	gonadotropin releasing hormone receptor	Rattus norvegicus	93-107
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	59-73
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	74-102
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	107-112
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	18-20	gonadotropin releasing hormone receptor	Rattus norvegicus	59-73
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	18-20	insulin-like growth factor 1	Rattus norvegicus	74-102
8630522-1	1996	Triiodothyronine (T3) is involved in the regulation of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis.	Triiodothyronine	18-20	insulin-like growth factor 1	Rattus norvegicus	107-112
8620345-1	1996	The thyroid hormone triiodothyronine (T3) is known to be a potent mediator of APOA1 gene expression.	Triiodothyronine	20-36	apolipoprotein A1	Homo sapiens	78-83
8620345-1	1996	The thyroid hormone triiodothyronine (T3) is known to be a potent mediator of APOA1 gene expression.	Triiodothyronine	38-40	apolipoprotein A1	Homo sapiens	78-83
8598220-1	1996	In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation.	Triiodothyronine	39-55	insulin	Homo sapiens	108-115
8598220-1	1996	In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation.	Triiodothyronine	39-55	transferrin	Homo sapiens	117-128
8598220-1	1996	In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation.	Triiodothyronine	57-59	insulin	Homo sapiens	108-115
8598220-1	1996	In a previous study we have shown that triiodothyronine (T3) added to a serum-free medium supplemented with insulin, transferrin, and selenous acid (ITS) can stimulate Caco-2 cell differentiation.	Triiodothyronine	57-59	transferrin	Homo sapiens	117-128
8567662-0	1996	Triiodothyronine induces the transcription of the uncoupling protein gene and stabilizes its mRNA in fetal rat brown adipocyte primary cultures.	Triiodothyronine	0-16	uncoupling protein 1	Rattus norvegicus	50-68
8635588-0	1996	Opposite regulation of bilirubin and 4-nitrophenol UDP-glucuronosyltransferase mRNA levels by 3,3",5 triiodo-L-thyronine in rat liver.	Triiodothyronine	94-120	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	51-78
8635588-1	1996	The effects of 3,3",5 triiodo-L-thyronine (L-T3) on the constitutive levels of hepatic mRNA encoding two UDP-glucuronosyltransferase (UGT) isoforms implicated in the glucuronidation of planar phenolic substrates (UGT1*06) and bilirubin (UGT1*0) were investigated in rat liver.	Triiodothyronine	43-47	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	105-132
8635588-5	1996	A good relationship observed between UGT activity toward 4-nitrophenol and bilirubin and mRNA levels emphasizes the key role played by the thyroid hormone L-T3 on UGT expression.	Triiodothyronine	155-159	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	37-40
8635588-5	1996	A good relationship observed between UGT activity toward 4-nitrophenol and bilirubin and mRNA levels emphasizes the key role played by the thyroid hormone L-T3 on UGT expression.	Triiodothyronine	155-159	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	163-166
8567662-2	1996	Treatment of confluent cells with 10 nM triiodothyronine in a serum-free medium, in the absence of noradrenergic stimulation, increased the amount of UCP mRNA in a time-dependent manner.	Triiodothyronine	40-56	uncoupling protein 1	Rattus norvegicus	150-153
8567662-4	1996	Thus, triiodothyronine might play a significant physiological role in the UCP expression throughout fetal development, when brown adipose tissue starts to differentiate and UCP is primarily expressed.	Triiodothyronine	6-22	uncoupling protein 1	Rattus norvegicus	74-77
8567662-4	1996	Thus, triiodothyronine might play a significant physiological role in the UCP expression throughout fetal development, when brown adipose tissue starts to differentiate and UCP is primarily expressed.	Triiodothyronine	6-22	uncoupling protein 1	Rattus norvegicus	173-176
8651954-2	1996	The use of the heterologous triiodothyronine-bovine serum albumin conjugate in immunoassays for thyroxine improved the sensitivity of these assays twofold and reduced the cross-reactivity with triiodothyronine from 1 to 0.5% as compared to the homologous variant.	Triiodothyronine	28-44	albumin	Homo sapiens	52-65
8651954-2	1996	The use of the heterologous triiodothyronine-bovine serum albumin conjugate in immunoassays for thyroxine improved the sensitivity of these assays twofold and reduced the cross-reactivity with triiodothyronine from 1 to 0.5% as compared to the homologous variant.	Triiodothyronine	193-209	albumin	Homo sapiens	52-65
8645609-6	1996	Amplification by triiodothyronine (T3) of CBG synthesis failed to block the inhibitory effects of either 1,25-D or retinoids, as revealed by both binding capacity and mRNA measurements.	Triiodothyronine	17-33	serpin family A member 6	Rattus norvegicus	42-45
8640446-1	1996	L-Thyroxine (T4) and 3,3",5-L-triiodothyronine (T3) potentiate the antiviral state induced by interferon-gamma(IFN-gamma) in homologous cells by a mechanism that is dependent upon calcium/phospholipid-dependent protein kinase (PKC).	Triiodothyronine	48-50	interferon gamma	Homo sapiens	94-120
8536624-11	1996	IGFBP-4, a known inhibitor of cellular proliferation, might contribute to the antiproliferative effect of T3 and retinoic acid on osteoblasts.	Triiodothyronine	106-108	insulin-like growth factor binding protein 4	Mus musculus	0-7
8836703-0	1996	Triiodothyronine and amiodarone effects on beta 3-adrenoceptor density and lipolytic response to the beta 3-adrenergic agonist BRL 37344 in rat white adipocytes.	Triiodothyronine	0-16	adrenoceptor beta 3	Rattus norvegicus	43-62
8645609-6	1996	Amplification by triiodothyronine (T3) of CBG synthesis failed to block the inhibitory effects of either 1,25-D or retinoids, as revealed by both binding capacity and mRNA measurements.	Triiodothyronine	35-37	serpin family A member 6	Rattus norvegicus	42-45
9035484-3	1996	Daily injections of 5 micrograms L-T3 for 7 days increased significantly the synthesis and storage of GH in pituitary gland, but the GH release was partially blocked.	Triiodothyronine	33-37	gonadotropin releasing hormone receptor	Rattus norvegicus	102-104
9035484-3	1996	Daily injections of 5 micrograms L-T3 for 7 days increased significantly the synthesis and storage of GH in pituitary gland, but the GH release was partially blocked.	Triiodothyronine	33-37	gonadotropin releasing hormone receptor	Rattus norvegicus	133-135
7501476-2	1995	Full activation of the 63 kDa keratin gene requires two regulatory steps, the first independent and the second dependent on the thyroid hormone triiodothyronine (T3).	Triiodothyronine	144-160	70a	Xenopus laevis	30-37
8524311-2	1996	Incubation of pituitary GH4C1 cells with nanomolar concentrations of vitamin D markedly reduces the response of the rat growth hormone mRNA to thyroid hormone triiodothyronine (T3) and RA.	Triiodothyronine	159-175	gonadotropin releasing hormone receptor	Rattus norvegicus	120-134
8524311-2	1996	Incubation of pituitary GH4C1 cells with nanomolar concentrations of vitamin D markedly reduces the response of the rat growth hormone mRNA to thyroid hormone triiodothyronine (T3) and RA.	Triiodothyronine	177-179	gonadotropin releasing hormone receptor	Rattus norvegicus	120-134
8530502-1	1995	We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1).	Triiodothyronine	85-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-133
8530502-1	1995	We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1).	Triiodothyronine	85-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
7487105-2	1995	An increase in transcription of the hepatic LDL receptor gene was seen within 30 min after administration of triiodothyronine.	Triiodothyronine	109-125	low density lipoprotein receptor	Rattus norvegicus	44-56
7501476-2	1995	Full activation of the 63 kDa keratin gene requires two regulatory steps, the first independent and the second dependent on the thyroid hormone triiodothyronine (T3).	Triiodothyronine	162-164	70a	Xenopus laevis	30-37
7491934-6	1995	In addition, free IGF-I correlated inversely (P < 0.005) with the 24-kDa IGFBP, 30-kDa IGFBP, and serum total triiodothyronine.	Triiodothyronine	113-129	insulin-like growth factor 1	Rattus norvegicus	18-23
7503757-9	1995	The joint administration of T3 and lindane, however, elicited a marked elevation in serum GOT and glutamate pyruvate transaminase (GPT), concomitantly with extensive liver necrosis and the presence of granulomas containing lymphocytes, Kupffer cells and polymorphonuclear leukocytes (PMN).	Triiodothyronine	28-30	glutamic--pyruvic transaminase	Rattus norvegicus	98-129
7503757-9	1995	The joint administration of T3 and lindane, however, elicited a marked elevation in serum GOT and glutamate pyruvate transaminase (GPT), concomitantly with extensive liver necrosis and the presence of granulomas containing lymphocytes, Kupffer cells and polymorphonuclear leukocytes (PMN).	Triiodothyronine	28-30	glutamic--pyruvic transaminase	Rattus norvegicus	131-134
8770628-6	1995	The serum concentrations of SHBG in patients with anorexia nervosa (165.27 +/- 63.5 nmol/l) were significantly higher (p < 0.01) than those in the control group (96.21 +/- 38.04 nmol/l), but the levels of estradiol, testosterone, free triiodothyronine and the ratio of testosterone to SHBG were significantly lower.	Triiodothyronine	238-254	sex hormone binding globulin	Homo sapiens	28-32
7588215-0	1995	Effect of 3,5,3"-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice.	Triiodothyronine	10-33	deiodinase, iodothyronine, type I	Mus musculus	57-61
7588215-0	1995	Effect of 3,5,3"-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice.	Triiodothyronine	35-37	deiodinase, iodothyronine, type I	Mus musculus	57-61
8581344-1	1995	The effect of growth (GH) and thyroid hormones (triiodothyronine, T3) on the expression of peroxisome proliferator-activated receptor (PPAR alpha) was examined using Northern blotting in primary cultures of rat hepatocytes.	Triiodothyronine	48-64	peroxisome proliferator activated receptor alpha	Rattus norvegicus	135-145
8675242-7	1995	Goitrogen intake not only caused an adaptive increase in the activity of type II 5"-deiodinase, which governs availability of triiodothyronine (T3) in brain, it also increased the latter"s binding to brain nuclear receptors under conditions of thiocyanate induced hypothyroid state.	Triiodothyronine	126-142	iodothyronine deiodinase 2	Rattus norvegicus	73-94
8675242-7	1995	Goitrogen intake not only caused an adaptive increase in the activity of type II 5"-deiodinase, which governs availability of triiodothyronine (T3) in brain, it also increased the latter"s binding to brain nuclear receptors under conditions of thiocyanate induced hypothyroid state.	Triiodothyronine	144-146	iodothyronine deiodinase 2	Rattus norvegicus	73-94
8674839-0	1995	Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells.	Triiodothyronine	14-30	insulin-like growth factor 1	Rattus norvegicus	54-82
8674839-0	1995	Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells.	Triiodothyronine	14-30	insulin-like growth factor 1	Rattus norvegicus	84-89
8674839-0	1995	Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells.	Triiodothyronine	14-30	insulin-like growth factor binding protein 3	Rattus norvegicus	95-139
8674839-0	1995	Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells.	Triiodothyronine	14-30	insulin-like growth factor binding protein 3	Rattus norvegicus	141-148
8674839-3	1995	At this density, the antiestrogen tamoxifen (TAM) had no significant effect, whereas triiodothyronine (T3), which has been demonstrated to increase the level of IGF-I mRNA in the parental GH3 cell line, stimulated IGF-I production by 3.3-fold.	Triiodothyronine	85-101	insulin-like growth factor 1	Rattus norvegicus	161-166
8674839-3	1995	At this density, the antiestrogen tamoxifen (TAM) had no significant effect, whereas triiodothyronine (T3), which has been demonstrated to increase the level of IGF-I mRNA in the parental GH3 cell line, stimulated IGF-I production by 3.3-fold.	Triiodothyronine	85-101	insulin-like growth factor 1	Rattus norvegicus	214-219
8674839-3	1995	At this density, the antiestrogen tamoxifen (TAM) had no significant effect, whereas triiodothyronine (T3), which has been demonstrated to increase the level of IGF-I mRNA in the parental GH3 cell line, stimulated IGF-I production by 3.3-fold.	Triiodothyronine	103-105	insulin-like growth factor 1	Rattus norvegicus	161-166
7574712-6	1995	Since 5"-ID1 catalyzes thyroxine conversion to the biologically active triiodothyronine, these data suggest that methoxychlor may interfere with thyroid hormone metabolism.	Triiodothyronine	71-87	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	9-12
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	15-38	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-123
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	15-38	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	134-140
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	15-38	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	150-156
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	15-38	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	161-167
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	40-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-123
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	40-42	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	134-140
8581344-1	1995	The effect of growth (GH) and thyroid hormones (triiodothyronine, T3) on the expression of peroxisome proliferator-activated receptor (PPAR alpha) was examined using Northern blotting in primary cultures of rat hepatocytes.	Triiodothyronine	66-68	peroxisome proliferator activated receptor alpha	Rattus norvegicus	135-145
7573440-1	1995	The stimulation of glucose transport by 3,5,3"-triiodo-L-thyronine (T3) in the liver-derived ARL 15 cell line is only partly attributable to increased GLUT-1 glucose transporter gene expression.	Triiodothyronine	68-70	solute carrier family 2 member 1	Homo sapiens	151-157
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	40-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	142-148
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	40-42	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	150-156
8577819-1	1995	The ability of 3,5,3"-triiodothyronine (T3) and cobalt-protoporphyrin LX (CoPP) to alter the levels of the cytochrome P-450 isoforms, CYP3A2, CYP2E1, CYP2B1 and CYP2B2, was examined in vitro in thyroidectomized adult male rats.	Triiodothyronine	40-42	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	161-167
8674831-3	1995	Here we first show that the synthetic glucocorticoid dexamethasone (Dex) potentiates and prolactin (PRL) suppresses, 3,3",5-triiodothyronine (T3)-induced regression of pre-metamorphic Xenopus tadpole tails in organ culture.	Triiodothyronine	117-140	prolactin, gene 2 L homeolog	Xenopus laevis	89-98
8674831-3	1995	Here we first show that the synthetic glucocorticoid dexamethasone (Dex) potentiates and prolactin (PRL) suppresses, 3,3",5-triiodothyronine (T3)-induced regression of pre-metamorphic Xenopus tadpole tails in organ culture.	Triiodothyronine	142-144	prolactin, gene 2 L homeolog	Xenopus laevis	89-98
7639710-1	1995	Transcription of the gene for phosphoenolpyruvate carboxy-kinase (PEPCK) is stimulated by thyroid hormone (T3), glucagon (via cyclic AMP) and glucocorticoids.	Triiodothyronine	107-109	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	30-64
7502703-0	1995	Triiodothyronine potentiates the stimulatory effects of interleukin-1 beta on bone resorption and medium interleukin-6 content in fetal rat limb bone cultures.	Triiodothyronine	0-16	interleukin 1 beta	Rattus norvegicus	56-74
7502703-0	1995	Triiodothyronine potentiates the stimulatory effects of interleukin-1 beta on bone resorption and medium interleukin-6 content in fetal rat limb bone cultures.	Triiodothyronine	0-16	interleukin 6	Rattus norvegicus	105-118
7651389-4	1995	Second, TR beta 2 was induced by triiodothyronine to transactivate more efficiently than TR beta 0 on palindromic and everted-repeat types of hormone response elements.	Triiodothyronine	33-49	thyroid hormone receptor beta	Gallus gallus	8-15
7639710-1	1995	Transcription of the gene for phosphoenolpyruvate carboxy-kinase (PEPCK) is stimulated by thyroid hormone (T3), glucagon (via cyclic AMP) and glucocorticoids.	Triiodothyronine	107-109	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	66-71
7614740-1	1995	We have studied the influence of triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), and methimazole (MMI) on the expression of major histocompatibility (MHC) Class II antigen expression in human thyroid cells.	Triiodothyronine	33-49	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	134-181
7549102-12	1995	The content of IGFBP-4 in the parenchymal cells was increased by insulin, Bu2cAMP, and triiodothyronine (T3), thereby enhancing the production of IGFBP-4 and secretion into the medium.	Triiodothyronine	87-103	insulin-like growth factor binding protein 4	Rattus norvegicus	15-22
7549102-12	1995	The content of IGFBP-4 in the parenchymal cells was increased by insulin, Bu2cAMP, and triiodothyronine (T3), thereby enhancing the production of IGFBP-4 and secretion into the medium.	Triiodothyronine	105-107	insulin-like growth factor binding protein 4	Rattus norvegicus	15-22
7549102-12	1995	The content of IGFBP-4 in the parenchymal cells was increased by insulin, Bu2cAMP, and triiodothyronine (T3), thereby enhancing the production of IGFBP-4 and secretion into the medium.	Triiodothyronine	105-107	insulin-like growth factor binding protein 4	Rattus norvegicus	146-153
7614740-0	1995	The influence of triiodothyronine, thyroxine, thyrotropin, and methimazole on thyroid cell MHC class II antigen expression.	Triiodothyronine	17-33	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	91-111
7614740-1	1995	We have studied the influence of triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), and methimazole (MMI) on the expression of major histocompatibility (MHC) Class II antigen expression in human thyroid cells.	Triiodothyronine	51-53	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	134-181
7662587-3	1995	Triiodothyronine and estradiol increased SHBG production, and cycloheximide reduced their effects to an extent which correlated with the degree of suppression obtained with the drug alone.	Triiodothyronine	0-16	sex hormone binding globulin	Homo sapiens	41-45
8568110-12	1995	Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01).	Triiodothyronine	0-16	insulin	Homo sapiens	133-140
8568110-12	1995	Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01).	Triiodothyronine	0-16	insulin	Homo sapiens	235-242
8568110-12	1995	Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01).	Triiodothyronine	18-20	insulin	Homo sapiens	133-140
8568110-12	1995	Triiodothyronine (T3) was directly correlated in the cancer patients with non-oxidative glucose utilization at the two physiological insulin concentrations (r = 0.673, p < 0.05 and r = 0.731, p < 0.01) and the supraphysiological insulin concentration (r = 0.791, p < 0.01).	Triiodothyronine	18-20	insulin	Homo sapiens	235-242
7662587-9	1995	Of the hormones, insulin decreased and triiodothyronine modestly increased SHBG mRNA levels, whereas estradiol had no clear effect.	Triiodothyronine	39-55	sex hormone binding globulin	Homo sapiens	75-79
7622469-2	1995	We used an antisense oligonucleotide to inhibit induction of spot 14 protein by T3 and glucose in primary cultures of rat hepatocytes to test the hypothesis that the protein could function in the regulation of lipid synthesis.	Triiodothyronine	80-82	thyroid hormone responsive	Rattus norvegicus	61-68
7602382-7	1995	In addition a novel role of triiodothyronine as inhibitor of growth factor induced transcriptional expression of regulatory genes (c-fos, c-jun) is suggested.	Triiodothyronine	28-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
7619082-3	1995	Here we report how growth hormone and tri-iodothyronine regulate the steroid-hydroxylating cytochrome P-450 (CYP) 3A forms, which are constitutively expressed mainly in the perivenous (downstream) liver region.	Triiodothyronine	38-55	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	91-116
7619082-9	1995	Treatment of hypophysectomized animals with tri-iodothyronine also suppressed the expression of CYP3A, both in males and females.	Triiodothyronine	44-61	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	96-101
7602382-7	1995	In addition a novel role of triiodothyronine as inhibitor of growth factor induced transcriptional expression of regulatory genes (c-fos, c-jun) is suggested.	Triiodothyronine	28-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
7733320-8	1995	In hypothyroid animals, the normal development of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase could be restored after treatment by triiodothyronine (T3).	Triiodothyronine	165-181	citrate synthase	Rattus norvegicus	78-94
7601115-4	1995	The regulation of FAS expression by glucose and hormones (insulin, dexamethasone and triiodothyronine) was studied in cultured hepatocytes from suckling rats.	Triiodothyronine	85-101	fatty acid synthase	Rattus norvegicus	18-21
7551681-7	1995	In spite of the increased lipid metabolism of the liver after resection, sensitivity of mRNA S14 expression to triiodothyronine and sucrose was unchanged and its regulation was operative in a positive manner.	Triiodothyronine	111-127	thyroid hormone responsive	Rattus norvegicus	93-96
7772604-2	1995	CSAD activity and enzyme protein concentration are both repressed by the action of the steroid family hormones triiodothyronine and estrogen.	Triiodothyronine	111-127	cysteine sulfinic acid decarboxylase	Rattus norvegicus	0-4
7591671-2	1995	It has been shown that thyroid hormones, such as 3,5,3"-triiodothyronine (T3), stimulate DNA transcription and down-regulate pADPRP activity.	Triiodothyronine	49-72	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131
7591671-2	1995	It has been shown that thyroid hormones, such as 3,5,3"-triiodothyronine (T3), stimulate DNA transcription and down-regulate pADPRP activity.	Triiodothyronine	74-76	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131
7621893-0	1995	Triiodo-L-thyronine enhances TRH-induced TSH release from perifused rat pituitaries and intracellular Ca2+ levels from dispersed pituitary cells.	Triiodothyronine	0-19	thyrotropin releasing hormone	Rattus norvegicus	29-32
7733320-8	1995	In hypothyroid animals, the normal development of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase could be restored after treatment by triiodothyronine (T3).	Triiodothyronine	165-181	carnitine O-acetyltransferase	Rattus norvegicus	100-127
7733320-8	1995	In hypothyroid animals, the normal development of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase could be restored after treatment by triiodothyronine (T3).	Triiodothyronine	183-185	citrate synthase	Rattus norvegicus	78-94
7733320-8	1995	In hypothyroid animals, the normal development of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase could be restored after treatment by triiodothyronine (T3).	Triiodothyronine	183-185	carnitine O-acetyltransferase	Rattus norvegicus	100-127
7623781-1	1995	The effect of triiodothyronine (T3) on regulation of fatty acid synthase in chicken liver was investigated.	Triiodothyronine	14-30	fatty acid synthase	Gallus gallus	53-72
7600766-11	1995	The response areas of plasma thyroxine and triiodothyronine to thyrotropin-releasing hormone injection were blunted (P < 0.01) in PTU-treated sheep compared with those of control sheep.	Triiodothyronine	43-59	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	63-92
7623781-1	1995	The effect of triiodothyronine (T3) on regulation of fatty acid synthase in chicken liver was investigated.	Triiodothyronine	32-34	fatty acid synthase	Gallus gallus	53-72
7867602-1	1995	In this study, we have demonstrated that retinoic acid (RA) and thyroid hormone (T3) stimulate the synthesis and release of human placental lactogen (hPL), one of the major secretory products of syncytiotrophoblast cells.	Triiodothyronine	81-83	chorionic somatomammotropin hormone 2	Homo sapiens	130-148
7795810-2	1995	Comparison of the binding of thyroxine, triiodothyronines and related compounds at the warfarin and indole sites of human serum albumin.	Triiodothyronine	40-57	albumin	Homo sapiens	122-135
7867602-1	1995	In this study, we have demonstrated that retinoic acid (RA) and thyroid hormone (T3) stimulate the synthesis and release of human placental lactogen (hPL), one of the major secretory products of syncytiotrophoblast cells.	Triiodothyronine	81-83	galectin 1	Homo sapiens	150-153
7540569-0	1995	Triiodothyronine modulates growth, secretory function and androgen receptor concentration in the prostatic carcinoma cell line LNCaP.	Triiodothyronine	0-16	androgen receptor	Homo sapiens	58-75
7877306-10	1995	Acute administration of triiodothyronine to postischemic hearts improved the preload recruitable stroke work area from 9.5 +/- 1.42 to 14.9 +/- 2.03 x 10(7) erg/ml, a 56% increase from baseline (p < 0.001), but had no effect on the preload recruitable stroke work area of the nonischemic hearts.	Triiodothyronine	24-40	ETS transcription factor ERG	Canis lupus familiaris	157-160
8529109-8	1995	RESULTS: Transfection studies using WT h-TR beta 1 in HeLa and NIH3T3 cells, showed that the 3,3",5-triiodothyronine (T3)-induced transactivation of the different TREs varied between cell types.	Triiodothyronine	67-69	T cell receptor beta locus	Homo sapiens	41-48
7840238-0	1995	Triiodothyronine stimulates renal epidermal growth factor expression in adult rat.	Triiodothyronine	0-16	epidermal growth factor like 1	Rattus norvegicus	34-57
7755659-0	1995	Response of 3-hydroxy-3-methylglutaryl CoA reductase to l-triiodothyronine in cultured fibroblasts from FH homozygotes.	Triiodothyronine	56-74	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	12-52
7755659-3	1995	Eleven out of 19 strains of cultured fibroblasts from FH homozygotes demonstrated high levels of the HMG CoA reductase activity when l-triiodothyronine was present in the culture medium.	Triiodothyronine	133-151	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	101-118
7755659-7	1995	The effect of l-triiodothyronine on HMG CoA reductase was abolished by cycloheximide, and not by actinomycin D.	Triiodothyronine	14-32	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	36-53
7755659-9	1995	The results indicate that the effect of l-triiodothyronine on HMG CoA reductase activity was a post-transcriptional event, required de novo protein synthesis, and was successful only when cholesterol was depleted from the cells.	Triiodothyronine	40-58	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	62-79
7755659-10	1995	The difference in the responsiveness of HMG CoA reductase activity to l-triiodothyronine treatment can be utilized to judge the state of impairment of LDL-receptors in the FH homozygote from the viewpoint of ability to incorporate cholesterol into the cells.	Triiodothyronine	70-88	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	40-57
7835286-5	1995	Coadministration of RA and T3 (10 micrograms/100g body wt) to either vitamin A-deficient or vitamin A-deficient, hypothyroid animals caused decreases in TSH beta mRNA content that were indistinguishable from those seen with T3 alone.	Triiodothyronine	27-29	thyroid stimulating hormone subunit beta	Rattus norvegicus	153-161
7772237-2	1995	The expression of an mRNA coding for the functional thyroid hormone receptor beta isoform, as established by the PCR assay, agrees with the presence of specific tri-iodothyronine (T3) -binding sites in the Sertoli cell nuclei of both species, as previously evaluated by displacement analysis.	Triiodothyronine	161-178	thyroid hormone receptor beta	Rattus norvegicus	52-81
7772237-2	1995	The expression of an mRNA coding for the functional thyroid hormone receptor beta isoform, as established by the PCR assay, agrees with the presence of specific tri-iodothyronine (T3) -binding sites in the Sertoli cell nuclei of both species, as previously evaluated by displacement analysis.	Triiodothyronine	180-182	thyroid hormone receptor beta	Rattus norvegicus	52-81
7840238-1	1995	To define the role that thyroid hormones play in regulation of renal epidermal growth factor (EGF) production, we characterized the effect of triiodothyronine (T3) administration on renal EGF expression in adult rats.	Triiodothyronine	142-158	epidermal growth factor like 1	Rattus norvegicus	188-191
7840238-1	1995	To define the role that thyroid hormones play in regulation of renal epidermal growth factor (EGF) production, we characterized the effect of triiodothyronine (T3) administration on renal EGF expression in adult rats.	Triiodothyronine	160-162	epidermal growth factor like 1	Rattus norvegicus	188-191
7706939-7	1995	Treatment of both primary and BFC-1 beta adipocytes with triiodothyronine alone had no effect on CRBP mRNA levels; however, when adipocytes were treated with a mixture of triiodothyronine and retinoic acid, the induction of CRBP mRNA levels by retinoic acid was reduced.	Triiodothyronine	57-73	retinol binding protein 1	Rattus norvegicus	224-228
7829605-5	1995	T3 (10 nmol/L) increased SHBG levels, but unlike the effect seen with steroids, the increase was equally evident within the cells and the medium.	Triiodothyronine	0-2	sex hormone binding globulin	Homo sapiens	25-29
7706939-7	1995	Treatment of both primary and BFC-1 beta adipocytes with triiodothyronine alone had no effect on CRBP mRNA levels; however, when adipocytes were treated with a mixture of triiodothyronine and retinoic acid, the induction of CRBP mRNA levels by retinoic acid was reduced.	Triiodothyronine	171-187	retinol binding protein 1	Rattus norvegicus	224-228
7706939-8	1995	In summary, these studies indicate that CRBP gene expression is regulated by retinoic acid, dexamethasone, and triiodothyronine; thus suggesting that retinol uptake, intracellular transport, and metabolism are dynamically regulated in adipocytes.	Triiodothyronine	111-127	retinol binding protein 1	Rattus norvegicus	40-44
7989311-4	1994	We provide evidence that the C-terminal activation domain of RXR can modulate the triiodothyronine (T3) responsiveness of TR/RXR heterodimers on reporter genes without altering the DNA binding properties of the heterodimers.	Triiodothyronine	82-98	retinoid X receptor alpha	Homo sapiens	61-64
7784255-0	1995	Triiodothyronine regulates somatostatin gene expression in cultured fetal rat cerebrocortical cells.	Triiodothyronine	0-16	somatostatin	Rattus norvegicus	27-39
7784255-1	1995	The effect of triiodothyronine (T3) on somatostatin (SS) mRNA levels in cultured fetal rat cerebrocortical cells was studied.	Triiodothyronine	32-34	somatostatin	Rattus norvegicus	39-51
7784255-1	1995	The effect of triiodothyronine (T3) on somatostatin (SS) mRNA levels in cultured fetal rat cerebrocortical cells was studied.	Triiodothyronine	32-34	somatostatin	Rattus norvegicus	53-55
8606955-1	1995	Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma.	Triiodothyronine	279-295	thyrotropin releasing hormone	Rattus norvegicus	19-49
8606955-1	1995	Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma.	Triiodothyronine	279-295	thyrotropin releasing hormone	Rattus norvegicus	51-54
8606955-1	1995	Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma.	Triiodothyronine	297-299	thyrotropin releasing hormone	Rattus norvegicus	19-49
8606955-1	1995	Clinical trials of thyrotrophin-releasing hormone (TRH) in conjunction with antepartum glucocorticoid treatment in the prevention of respiratory distress syndrome is based on experimental evidence that fetal lung maturation is accelerated by exposure to raised concentrations of triiodothyronine (T3) in fetal plasma.	Triiodothyronine	297-299	thyrotropin releasing hormone	Rattus norvegicus	51-54
7989311-4	1994	We provide evidence that the C-terminal activation domain of RXR can modulate the triiodothyronine (T3) responsiveness of TR/RXR heterodimers on reporter genes without altering the DNA binding properties of the heterodimers.	Triiodothyronine	82-98	retinoid X receptor alpha	Homo sapiens	125-128
7989311-4	1994	We provide evidence that the C-terminal activation domain of RXR can modulate the triiodothyronine (T3) responsiveness of TR/RXR heterodimers on reporter genes without altering the DNA binding properties of the heterodimers.	Triiodothyronine	100-102	retinoid X receptor alpha	Homo sapiens	61-64
7989311-4	1994	We provide evidence that the C-terminal activation domain of RXR can modulate the triiodothyronine (T3) responsiveness of TR/RXR heterodimers on reporter genes without altering the DNA binding properties of the heterodimers.	Triiodothyronine	100-102	retinoid X receptor alpha	Homo sapiens	125-128
7711295-9	1994	Triiodothyronine administration altered both ornithine decarboxylase and thymidine kinase activities suggesting that T3 appears to regulate ornithine decarboxylase activity at post-translational level.	Triiodothyronine	0-16	ornithine decarboxylase 1	Rattus norvegicus	45-68
7711295-9	1994	Triiodothyronine administration altered both ornithine decarboxylase and thymidine kinase activities suggesting that T3 appears to regulate ornithine decarboxylase activity at post-translational level.	Triiodothyronine	0-16	ornithine decarboxylase 1	Rattus norvegicus	140-163
7873749-1	1994	Generalized resistance to thyroid hormone (GRTH) is characterized by elevated circulating levels of thyroid hormone in the presence of a eumetabolic state and failure to respond to triiodothyronine.	Triiodothyronine	181-197	thyroid hormone receptor beta	Homo sapiens	43-47
7999013-1	1994	Basal and stimulated activity of the c-fos promoter is reduced by triiodothyronine (T3) and retinoic acid (RA) in GH1 cells.	Triiodothyronine	66-82	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
7999013-1	1994	Basal and stimulated activity of the c-fos promoter is reduced by triiodothyronine (T3) and retinoic acid (RA) in GH1 cells.	Triiodothyronine	84-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
7767864-2	1994	Administration of replacement doses of triiodothyronine (3 or 10 micrograms/kg for 3 days) to diabetic rats normalized heparin-releasable lipoprotein lipase activity in perfused hearts, but the depressed lipoprotein lipase activity in cardiomyocytes from diabetic hearts was unchanged by in vivo thyroid hormone treatment.	Triiodothyronine	39-55	lipoprotein lipase	Rattus norvegicus	138-156
7979399-3	1994	It was found that increased levels of LDL receptor mRNA could be detected 30 min after giving hypophysectomized rats an intramuscular injection of 10 micrograms of L-triiodothyronine (T3) per 100 g of body weight.	Triiodothyronine	164-182	low density lipoprotein receptor	Rattus norvegicus	38-50
7979399-3	1994	It was found that increased levels of LDL receptor mRNA could be detected 30 min after giving hypophysectomized rats an intramuscular injection of 10 micrograms of L-triiodothyronine (T3) per 100 g of body weight.	Triiodothyronine	184-186	low density lipoprotein receptor	Rattus norvegicus	38-50
7767864-2	1994	Administration of replacement doses of triiodothyronine (3 or 10 micrograms/kg for 3 days) to diabetic rats normalized heparin-releasable lipoprotein lipase activity in perfused hearts, but the depressed lipoprotein lipase activity in cardiomyocytes from diabetic hearts was unchanged by in vivo thyroid hormone treatment.	Triiodothyronine	39-55	lipoprotein lipase	Rattus norvegicus	204-222
7894889-4	1994	While the physiological amounts of both triiodothyronine (T3) and thyroxine (T4) stimulated ODC activity after 2 hr of treatment, only T3 had the same stimulatory effect after 4 hr of treatment.	Triiodothyronine	40-56	ornithine decarboxylase	Gallus gallus	92-95
7828350-0	1994	Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults.	Triiodothyronine	106-122	growth hormone 1	Homo sapiens	0-14
7894889-4	1994	While the physiological amounts of both triiodothyronine (T3) and thyroxine (T4) stimulated ODC activity after 2 hr of treatment, only T3 had the same stimulatory effect after 4 hr of treatment.	Triiodothyronine	58-60	ornithine decarboxylase	Gallus gallus	92-95
7986828-0	1994	Vitamin D-dependent rickets type II: regulation of human osteocalcin gene expression in cells with defective vitamin D receptors by 1,25-dihydroxyvitamin D-3, retinoic acid, and triiodothyronine.	Triiodothyronine	178-194	bone gamma-carboxyglutamate protein	Homo sapiens	57-68
7829685-2	1994	The study was designed to determine whether the expected interleukin 6 increases after surgery are the cause of decreased serum tri-iodothyronine (T3) concentration normally observed following severe trauma.	Triiodothyronine	128-145	interleukin 6	Homo sapiens	57-70
7986828-5	1994	To try to understand these clinical findings, the complex formed between the VDRE and one or more proteins in the nuclear extracts of cultured skin fibroblasts treated with 1,25-dihydroxyvitamin D-3 (1,25(OH)2D3), retinoic acid (RA), and/or triiodothyronine (T3) was investigated since such complexes are likely to precede the transcription of the VDR gene.	Triiodothyronine	241-257	vitamin D receptor	Homo sapiens	77-80
7986828-5	1994	To try to understand these clinical findings, the complex formed between the VDRE and one or more proteins in the nuclear extracts of cultured skin fibroblasts treated with 1,25-dihydroxyvitamin D-3 (1,25(OH)2D3), retinoic acid (RA), and/or triiodothyronine (T3) was investigated since such complexes are likely to precede the transcription of the VDR gene.	Triiodothyronine	259-261	vitamin D receptor	Homo sapiens	77-80
7986828-6	1994	Complex formation in the control cells with an intact VDR was increased by treatment with either 0.1 nM, 1 nM, 10 nM 1,25(OH)2D3, 100 nM RA, or 100 nM T3; however, combinations of these compounds did not produce an additive effect.	Triiodothyronine	151-153	vitamin D receptor	Homo sapiens	54-57
7829685-2	1994	The study was designed to determine whether the expected interleukin 6 increases after surgery are the cause of decreased serum tri-iodothyronine (T3) concentration normally observed following severe trauma.	Triiodothyronine	147-149	interleukin 6	Homo sapiens	57-70
7929226-10	1994	During 3,5,3"-L-triiodothyronine (T3)-induced metamorphosis, the nonhepatic arginase genes are activated very quickly, whereas the liver arginase gene is a late T3 response gene.	Triiodothyronine	34-36	arginase 2 S homeolog	Xenopus laevis	65-84
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	90-109	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	184-190
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	90-109	insulin like growth factor 1	Homo sapiens	245-273
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	90-109	insulin like growth factor 1	Homo sapiens	275-280
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	111-113	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	184-190
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	111-113	insulin like growth factor 1	Homo sapiens	245-273
7980406-1	1994	The aim of this study was to investigate the mechanism(s) underlying the thyroid-hormone (L-tri-iodothyronine, T3)-induced elevation of fast-type sarcoplasmic-reticulum Ca(2+)-ATPase (SERCA1) levels in L6 myotubes and the potentiating effect of insulin-like growth factor-I (IGF-I) [Muller, van Hardeveld, Simonides and van Rijn (1991) Biochem.	Triiodothyronine	111-113	insulin like growth factor 1	Homo sapiens	275-280
7918604-1	1994	The induction of hepatic cholesterol 7 alpha-hydroxylase mRNA by triiodothyronine was investigated in hypophysectomized rats.	Triiodothyronine	65-81	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	25-56
7934981-1	1994	To investigate the uptake of triiodothyronine sulfate (T3S) and its effect on thyrotropin-releasing hormone (TRH)-induced thyrotropin (TSH) secretion, anterior pituitary cells were isolated from euthyroid rats and cultured for 3 days in medium containing 10% fetal calf serum.	Triiodothyronine	55-58	thyrotropin releasing hormone	Rattus norvegicus	109-112
7945243-0	1994	Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture.	Triiodothyronine	40-57	fatty acid synthase	Gallus gallus	80-99
7945243-2	1994	In chick-embryo hepatocytes in culture, insulin amplifies the tri-iodothyronine (T3)-induced enzyme activity, and the level and rate of transcription of mRNA for both fatty acid synthase (FAS) and malic enzyme (ME).	Triiodothyronine	62-79	insulin	Gallus gallus	40-47
7945243-2	1994	In chick-embryo hepatocytes in culture, insulin amplifies the tri-iodothyronine (T3)-induced enzyme activity, and the level and rate of transcription of mRNA for both fatty acid synthase (FAS) and malic enzyme (ME).	Triiodothyronine	81-83	insulin	Gallus gallus	40-47
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	51-67	a1-a	Xenopus laevis	137-149
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	51-67	a1-a	Xenopus laevis	151-154
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	69-71	a1-a	Xenopus laevis	137-149
7821717-1	1994	Earlier studies from our laboratory had shown that triiodothyronine (T3) strongly potentiates the activation by estradiol (E2) of silent vitellogenin (Vit) genes and the autoinduction of estrogen receptor (ER) mRNA in primary cultures of male Xenopus hepatocytes (Rabelo and Tata, 1993).	Triiodothyronine	69-71	a1-a	Xenopus laevis	151-154
7836151-1	1994	The present studies were designed to test the hypothesis that arginine vasopressin (AVP) can interact with hydrocortisone and 3,5,3"-triiodothyronine (T3) to induce maturation of lung liquid reabsorptive processes in fetal sheep < 130 days gestation.	Triiodothyronine	126-149	vasopressin-neurophysin 2-copeptin	Ovis aries	84-87
7821717-4	1994	This induction of ER mRNA is accompanied by a marked enhancement of the activation of the silent Vit B1 gene if E2 is added by 12 h after T3 and Dex, thus suggesting an elevated level of functional ER induced by the two hormones.	Triiodothyronine	138-140	vitellogenin B1 L homeolog	Xenopus laevis	97-103
7938043-2	1994	Although levels of mRNA-S14 were stimulated by L-triiodothyronine (T3) in both young and aged animals, net activity of the gene in response to the hormone was reduced approximately 2-fold in the aged rats.	Triiodothyronine	47-65	thyroid hormone responsive	Rattus norvegicus	24-27
7938043-2	1994	Although levels of mRNA-S14 were stimulated by L-triiodothyronine (T3) in both young and aged animals, net activity of the gene in response to the hormone was reduced approximately 2-fold in the aged rats.	Triiodothyronine	67-69	thyroid hormone responsive	Rattus norvegicus	24-27
7836151-1	1994	The present studies were designed to test the hypothesis that arginine vasopressin (AVP) can interact with hydrocortisone and 3,5,3"-triiodothyronine (T3) to induce maturation of lung liquid reabsorptive processes in fetal sheep < 130 days gestation.	Triiodothyronine	151-153	vasopressin-neurophysin 2-copeptin	Ovis aries	84-87
8051127-1	1994	The selenoenzyme, type 1 iodothyronine deiodinase (type 1 DI), catalyzes the activation of thyroxine (T4) to 3,5,3"-triiodothyronine (T3) but 3,3",5"-triiodothyronine (rT3) is the preferred substrate for the human enzyme.	Triiodothyronine	134-136	type I iodothyronine deiodinase	Canis lupus familiaris	51-60
7883064-0	1994	Effect of triiodothyronine and in vitro growth hormone on avian interleukin-2.	Triiodothyronine	10-26	interleukin 15	Gallus gallus	64-77
7951671-6	1994	Patients with GRTH and PRTH both present with elevated free thyroxine and triiodothyronine and inappropriately normal thyroid-stimulating hormone, but the former patients are clinically euthyroid, whereas the latter patients have symptoms and signs of hyperthyroidism.	Triiodothyronine	74-90	thyroid hormone receptor beta	Homo sapiens	14-18
8042994-0	1994	Effects of tri-iodothyronine administration on the disposal of oral [1-14C]triolein, lipoprotein lipase activity and lipogenesis in the rat during lactation and on removal of the litter.	Triiodothyronine	11-28	lipoprotein lipase	Rattus norvegicus	85-103
8076904-6	1994	However, the UDPGT activity for p-nitrophenol increased two-fold in estradiol and T3-treated females (p < 0.01), but was not significantly altered by testosterone treatment.	Triiodothyronine	82-84	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	13-18
8007990-11	1994	GATA-4 DNA binding activity was significantly up-regulated in triiodothyronine- or retinoic acid-treated cardiomyocytes.	Triiodothyronine	62-78	GATA binding protein 4	Homo sapiens	0-6
8023910-1	1994	We found in preliminary experiments that multiple daily injections of triiodothyronine (T3) resulted in an apparent prolongation in the half time (t1/2) of mRNA-S14 decay.	Triiodothyronine	70-86	thyroid hormone responsive	Rattus norvegicus	161-164
8023910-1	1994	We found in preliminary experiments that multiple daily injections of triiodothyronine (T3) resulted in an apparent prolongation in the half time (t1/2) of mRNA-S14 decay.	Triiodothyronine	88-90	thyroid hormone responsive	Rattus norvegicus	161-164
8033262-1	1994	The type I iodothyronine deiodinase (ID-I) in liver and kidney converts the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3",5-triiodothyronine (T3) or by inner ring deiodination (IRD) to inactive 3,3",5-triiodothronine (rT3), while it also catalyzes the IRD of T3 and the ORD of rT3, with the latter as the preferred substrate.	Triiodothyronine	173-175	iodothyronine deiodinase 1	Homo sapiens	4-35
8062112-0	1994	Increased sensitivity to triiodothyronine (T3) of broiler lines with a high susceptibility for ascites.	Triiodothyronine	25-41	T3	Gallus gallus	43-45
8062112-2	1994	In the studies reported here, broiler lines divergently selected for susceptibility to ascites under low temperature conditions were tested for their sensitivity to 3,3",5-triiodothyronine (T3) with respect to growth rate, rate of mortality, plasma concentrations of T3, right ventricular hypertrophy (RVH) and incidence of ascites.	Triiodothyronine	165-188	T3	Gallus gallus	190-192
8062902-1	1994	Laboratory experiments have demonstrated that tetra- and triiodothyronine (T4, T3) enhance hypoxia-induced erythropoietin (Epo) production.	Triiodothyronine	79-81	erythropoietin	Homo sapiens	107-121
8062902-1	1994	Laboratory experiments have demonstrated that tetra- and triiodothyronine (T4, T3) enhance hypoxia-induced erythropoietin (Epo) production.	Triiodothyronine	79-81	erythropoietin	Homo sapiens	123-126
7514646-1	1994	Type II 5"-deiodinase (D-II) catalyzes the intracellular conversion of thyroxine (T4) to 3,5,3"-triiodothyronine (T3) in the brain.	Triiodothyronine	114-116	iodothyronine deiodinase 2	Homo sapiens	0-21
7514032-0	1994	Antagonistic effects of retinoic acid and triiodothyronine in the expression of corticoid-binding globulin (CBG) by cultured fetal hepatocytes.	Triiodothyronine	42-58	serpin family A member 6	Rattus norvegicus	80-106
8188744-3	1994	Vitamin D3 and thyroid hormone T3, that activate retinoic acid receptor (RAR) cognates, forming heterodimers with retinoid X receptor (RXR), do not affect the potency of immunotoxins.	Triiodothyronine	15-33	retinoic acid receptor alpha	Homo sapiens	73-76
8188744-3	1994	Vitamin D3 and thyroid hormone T3, that activate retinoic acid receptor (RAR) cognates, forming heterodimers with retinoid X receptor (RXR), do not affect the potency of immunotoxins.	Triiodothyronine	15-33	retinoid X receptor alpha	Homo sapiens	114-133
8188744-3	1994	Vitamin D3 and thyroid hormone T3, that activate retinoic acid receptor (RAR) cognates, forming heterodimers with retinoid X receptor (RXR), do not affect the potency of immunotoxins.	Triiodothyronine	15-33	retinoid X receptor alpha	Homo sapiens	135-138
8157727-3	1994	OC and Pyr levels were elevated above the normal range in most patients and were significantly correlated with serum free T3 concentrations (r = 0.53; P < 0.01 and r = 0.76; P < 0.001; for OC and Pyr, respectively).	Triiodothyronine	122-124	bone gamma-carboxyglutamate protein	Homo sapiens	0-2
7514032-0	1994	Antagonistic effects of retinoic acid and triiodothyronine in the expression of corticoid-binding globulin (CBG) by cultured fetal hepatocytes.	Triiodothyronine	42-58	serpin family A member 6	Rattus norvegicus	108-111
7514032-1	1994	Cultures of rat fetal hepatocytes were used to investigate the effects and interplay of triiodothyronine (T3) and retinoic acid (RA) in the regulation of gene expression of CBG, compared to that of alpha-fetoprotein (AFP).	Triiodothyronine	88-104	serpin family A member 6	Rattus norvegicus	173-176
7514032-1	1994	Cultures of rat fetal hepatocytes were used to investigate the effects and interplay of triiodothyronine (T3) and retinoic acid (RA) in the regulation of gene expression of CBG, compared to that of alpha-fetoprotein (AFP).	Triiodothyronine	106-108	serpin family A member 6	Rattus norvegicus	173-176
7509290-3	1994	L-triiodothyronine and L-thyroxine stimulated hypoxia-induced Epo formation both in the kidney and in HepG2 cells in a dose-dependent fashion.	Triiodothyronine	0-18	erythropoietin	Homo sapiens	62-65
8171058-0	1994	Triiodothyronine reduces growth hormone secretion and pituitary growth hormone mRNA in the chicken, in vivo and in vitro.	Triiodothyronine	0-16	growth hormone	Gallus gallus	25-39
8171058-0	1994	Triiodothyronine reduces growth hormone secretion and pituitary growth hormone mRNA in the chicken, in vivo and in vitro.	Triiodothyronine	0-16	growth hormone	Gallus gallus	64-78
8171058-1	1994	The influence of triiodothyronine (T3) on growth hormone (GH) mRNA and GH secretion has been examined in the chicken.	Triiodothyronine	35-37	growth hormone	Gallus gallus	42-56
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	0-23	apoptosis antagonizing transcription factor	Mus musculus	65-72
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	0-23	acetylcholinesterase	Mus musculus	298-318
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	0-23	acetylcholinesterase	Mus musculus	320-324
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	25-27	apoptosis antagonizing transcription factor	Mus musculus	65-72
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	25-27	acetylcholinesterase	Mus musculus	298-318
8146169-2	1994	3,5,3"-Triiodothyronine (T3) treatment of cells that overexpress TR beta 1 blocks proliferation by an arrest of cells in G0/G1 and induces morphological and functional differentiation of Neuro-2a cells as indicated by the marked increase in the number of perisomatal filopodia-like neurites and in acetylcholinesterase (AChE) activity.	Triiodothyronine	25-27	acetylcholinesterase	Mus musculus	320-324
8307979-4	1994	In rat pituitary tumor cells (GH3), transient expression of plasmid constructs containing the putative nT3RE of rTSH beta mediated negative regulation by L-triiodothyronine (T3).	Triiodothyronine	154-172	thyroid stimulating hormone subunit beta	Rattus norvegicus	112-121
24203110-11	1994	Treatment of postspawned grilse in February and March with triiodothyronine and thyroxine elevated plasma thyroid hormone levels and increased plasma ALP levels.	Triiodothyronine	59-75	Alkaline phosphatase	Salmo salar	150-153
8127707-11	1994	These results provide a molecular mechanism/model for the effects of triiodo-L-thyronine on in vitro myogenesis; the activation of myoD gene expression in the slow twitch fibres and the cascade of myogenic events regulated by thyroid hormone.	Triiodothyronine	69-88	myogenic differentiation 1	Mus musculus	131-135
8194741-0	1994	Growth hormone secretory characteristics of sex-linked dwarf and normal-sized chickens reared on a control or on a 3,3",5-triiodothyronine-supplemented diet.	Triiodothyronine	115-138	growth hormone	Gallus gallus	0-14
8127707-0	1994	Activation of myoD gene transcription by 3,5,3"-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors.	Triiodothyronine	41-67	myogenic differentiation 1	Mus musculus	14-18
8127707-2	1994	Triiodo-L-thyronine treatment promotes terminal muscle differentiation and results in increased MyoD gene transcription in myogenic cell lines; furthermore myoD and fast myosin heavy chain gene expression are activated in rodent slow twitch muscle fibers (Molecular Endocrinology 6: 1185-1194, 1992; Development 118: 1137-1147, 1993).	Triiodothyronine	0-19	myogenic differentiation 1	Mus musculus	96-100
8307979-4	1994	In rat pituitary tumor cells (GH3), transient expression of plasmid constructs containing the putative nT3RE of rTSH beta mediated negative regulation by L-triiodothyronine (T3).	Triiodothyronine	104-106	thyroid stimulating hormone subunit beta	Rattus norvegicus	112-121
8299556-7	1994	Treatment of the cells with the calmodulin antagonist CGS 9343 B stimulated the uptake of leucine and tryptophan, but inhibited the uptake of T3.	Triiodothyronine	142-144	calmodulin 1	Homo sapiens	32-42
8130892-0	1994	Stimulation of sex hormone-binding globulin mRNA and attenuation of corticosteroid-binding globulin mRNA by triiodothyronine in human hepatoma cells.	Triiodothyronine	108-124	serpin family A member 6	Homo sapiens	68-99
8299578-10	1994	The combination of 10(-9) M T3 and 10(-8) M Dex dramatically potentiated the effect of either treatment alone (T3, 8.9-fold rise; Dex, 37.2-fold rise) and increased TRH accumulation 251.2-fold (all P < 0.01).	Triiodothyronine	28-30	thyrotropin releasing hormone	Rattus norvegicus	165-168
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	53-69	sex hormone binding globulin	Homo sapiens	95-123
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	53-69	sex hormone binding globulin	Homo sapiens	125-129
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	53-69	serpin family A member 6	Homo sapiens	135-166
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	53-69	serpin family A member 6	Homo sapiens	168-171
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	71-73	sex hormone binding globulin	Homo sapiens	95-123
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	71-73	sex hormone binding globulin	Homo sapiens	125-129
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	71-73	serpin family A member 6	Homo sapiens	135-166
8130892-1	1994	We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2.	Triiodothyronine	71-73	serpin family A member 6	Homo sapiens	168-171
8280758-9	1994	T4 and 3,5,3"-L-triiodothyronine (T3) shifted the fluorescence emission maximum and intensity of an ANS-TTR solution toward the spectrum obtained from uncomplexed ANS.	Triiodothyronine	34-36	transthyretin	Homo sapiens	104-107
8288635-3	1994	The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons.	Triiodothyronine	43-59	neurotrophin 3	Rattus norvegicus	87-91
8288635-3	1994	The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons.	Triiodothyronine	61-63	neurotrophin 3	Rattus norvegicus	87-91
8276832-11	1994	Triiodothyronine decreased both phosphorylated and unphosphorylated hTR beta-1 homodimer binding to several TREs, and the addition of okadaic acid did not alter this triiodothyronine effect.	Triiodothyronine	0-16	telomerase RNA component	Homo sapiens	68-71
7851842-0	1994	Effects of triiodothyronine and dexamethasone on plasma and tissue angiotensin converting enzyme in the rat.	Triiodothyronine	11-27	angiotensin I converting enzyme	Rattus norvegicus	67-96
7796640-0	1994	Age-related difference in the in vitro response of erythropoietin to triiodothyronine in male rats.	Triiodothyronine	69-85	erythropoietin	Rattus norvegicus	51-65
8269993-2	1994	Insulin and triiodothyronine (T3), separately, increase G6PD mRNA expression, producing an additive effect at 64 h when combined.	Triiodothyronine	12-28	glucose-6-phosphate dehydrogenase	Homo sapiens	56-60
8269993-2	1994	Insulin and triiodothyronine (T3), separately, increase G6PD mRNA expression, producing an additive effect at 64 h when combined.	Triiodothyronine	30-32	glucose-6-phosphate dehydrogenase	Homo sapiens	56-60
7664533-0	1994	Regulation of glucokinase gene expression in cultured rat islet cells: the inhibitory effects of T3 and glucagon, and the stimulatory effect of glibenclamide.	Triiodothyronine	97-99	glucokinase	Rattus norvegicus	14-25
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	22-38	a1-a	Xenopus laevis	82-94
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	22-38	a1-a	Xenopus laevis	96-99
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	40-42	a1-a	Xenopus laevis	82-94
8186148-4	1994	Here we report on how triiodothyronine (T3) enhances the precocious activation of vitellogenin (Vit) genes by estradiol (E2) in Xenopus tadpoles during metamorphosis.	Triiodothyronine	40-42	a1-a	Xenopus laevis	96-99
8119677-0	1993	In vivo effect of gold compounds on thyroxine to triiodothyronine conversion by type I 5"-deiodinase in patients with rheumatoid arthritis.	Triiodothyronine	49-65	iodothyronine deiodinase 1	Homo sapiens	80-100
8274152-4	1993	Treatment of diabetic rats with thyroid hormone (T3) as well as with insulin reversed the increase in the levels of CYP4A2 and P450 K-2.	Triiodothyronine	49-51	cytochrome P450, family 4, subfamily a, polypeptide 2	Rattus norvegicus	116-122
8274152-4	1993	Treatment of diabetic rats with thyroid hormone (T3) as well as with insulin reversed the increase in the levels of CYP4A2 and P450 K-2.	Triiodothyronine	49-51	cytochrome P450, family 4, subfamily a, polypeptide 2	Rattus norvegicus	133-135
8121618-2	1993	SD induced a significant rise in the activity of iodothyronine type II 5"-deiodinase (5"D-II), which catalyzes the conversion of thyroxine (T4) to triiodothyronine (T3) in the rat central nervous system (CNS).	Triiodothyronine	147-163	iodothyronine deiodinase 2	Rattus norvegicus	63-84
8121618-2	1993	SD induced a significant rise in the activity of iodothyronine type II 5"-deiodinase (5"D-II), which catalyzes the conversion of thyroxine (T4) to triiodothyronine (T3) in the rat central nervous system (CNS).	Triiodothyronine	147-163	iodothyronine deiodinase 2	Rattus norvegicus	86-92
8121618-2	1993	SD induced a significant rise in the activity of iodothyronine type II 5"-deiodinase (5"D-II), which catalyzes the conversion of thyroxine (T4) to triiodothyronine (T3) in the rat central nervous system (CNS).	Triiodothyronine	165-167	iodothyronine deiodinase 2	Rattus norvegicus	63-84
8121618-2	1993	SD induced a significant rise in the activity of iodothyronine type II 5"-deiodinase (5"D-II), which catalyzes the conversion of thyroxine (T4) to triiodothyronine (T3) in the rat central nervous system (CNS).	Triiodothyronine	165-167	iodothyronine deiodinase 2	Rattus norvegicus	86-92
8414512-1	1993	Triiodothyronine (T3) positively regulates both the expression of the MyoD gene, a key myogenic regulator, and C2 muscle cell differentiation.	Triiodothyronine	0-16	myogenic differentiation 1	Homo sapiens	70-74
8226882-1	1993	Incubation with 1 nM triiodothyronine (T3) decreased cycloheximide-induced c-fos mRNA levels and the mRNA response to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 100 nM) or to forskolin (15 microM).	Triiodothyronine	21-37	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
8226882-1	1993	Incubation with 1 nM triiodothyronine (T3) decreased cycloheximide-induced c-fos mRNA levels and the mRNA response to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 100 nM) or to forskolin (15 microM).	Triiodothyronine	39-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
8218343-2	1993	Insulin, triiodothyronine and dexamethasone markedly stimulated the inductions of the enzymes (particularly G6PD and ME) in the presence of pyruvate.	Triiodothyronine	9-25	glucose-6-phosphate dehydrogenase	Rattus norvegicus	108-112
8297796-2	1993	Triiodo-L-thyronine (T3) treatment of myogenic cell lines results in the precocious expression of myogenin, a muscle specific, helix-loop-helix factor that can trans-activate muscle specific gene expression (G. Carnac et al., Mol.	Triiodothyronine	0-19	myogenin	Mus musculus	98-106
8297796-2	1993	Triiodo-L-thyronine (T3) treatment of myogenic cell lines results in the precocious expression of myogenin, a muscle specific, helix-loop-helix factor that can trans-activate muscle specific gene expression (G. Carnac et al., Mol.	Triiodothyronine	21-23	myogenin	Mus musculus	98-106
8414512-1	1993	Triiodothyronine (T3) positively regulates both the expression of the MyoD gene, a key myogenic regulator, and C2 muscle cell differentiation.	Triiodothyronine	18-20	myogenic differentiation 1	Homo sapiens	70-74
8238361-11	1993	Caco-2 cells transfected with 5" flanking regions of the human Na(+)-K(+)-ATPase beta 1-gene linked to the chloramphenicol acetyltransferase (CAT) reporter gene responded to 3,5,3"-triiodothyronine (T3) treatment with increased expression of CAT activity.	Triiodothyronine	199-201	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	81-87
8408055-1	1993	We have shown that culturing HepG2 cells in Ham"s F-12 medium supplemented with calf serum, dexamethasone, and triiodothyronine causes an increase in the insulin sensitivity and responsiveness for glucose incorporation into glycogen.	Triiodothyronine	111-127	insulin	Homo sapiens	154-161
8345811-4	1993	The in vitro effects of triiodothyronine (T3) and T4 on the release of BNP were examined in newborn rat atrial and ventricular myocytes in primary culture.	Triiodothyronine	24-40	natriuretic peptide B	Rattus norvegicus	71-74
7507935-1	1993	The purpose of this study was to assess possible effects of tri-iodothyronine (T3) on the production of alpha fetoprotein (AFP) and albumin by mouse fetal liver cells.	Triiodothyronine	60-77	alpha fetoprotein	Mus musculus	104-127
7507935-1	1993	The purpose of this study was to assess possible effects of tri-iodothyronine (T3) on the production of alpha fetoprotein (AFP) and albumin by mouse fetal liver cells.	Triiodothyronine	79-81	alpha fetoprotein	Mus musculus	104-127
8214040-1	1993	The objectives of this study were to 1) examine the effect of hypo- and hyperthyroidism (triiodothyronine treatment) on the distribution of type IIA myosin heavy chain (MHC) in the soleus at the single fiber level and 2) correlate changes in the single fiber distribution of type IIA MHC with the maximal shortening velocity of whole skeletal muscle.	Triiodothyronine	89-105	myosin heavy chain 2	Homo sapiens	140-167
8214040-1	1993	The objectives of this study were to 1) examine the effect of hypo- and hyperthyroidism (triiodothyronine treatment) on the distribution of type IIA myosin heavy chain (MHC) in the soleus at the single fiber level and 2) correlate changes in the single fiber distribution of type IIA MHC with the maximal shortening velocity of whole skeletal muscle.	Triiodothyronine	89-105	major histocompatibility complex, class I, C	Homo sapiens	169-172
8664159-12	1993	Administration of triiodothyronine (T3) to early tadpoles (stages 50/52) caused a rapid upregulation of TR alpha and beta mRNAs which was particularly marked for the beta transcript (20- to 50-fold increase in steady-state levels).	Triiodothyronine	18-34	T cell receptor alpha locus L homeolog	Xenopus laevis	104-112
8664159-12	1993	Administration of triiodothyronine (T3) to early tadpoles (stages 50/52) caused a rapid upregulation of TR alpha and beta mRNAs which was particularly marked for the beta transcript (20- to 50-fold increase in steady-state levels).	Triiodothyronine	36-38	T cell receptor alpha locus L homeolog	Xenopus laevis	104-112
7507935-0	1993	The regulatory role of tri-iodothyronine on the production of alpha-fetoprotein and albumin by mouse fetal liver cells.	Triiodothyronine	23-40	alpha fetoprotein	Mus musculus	62-79
8214025-1	1993	The purpose of this study was to determine the pattern of thyroid hormone (triiodothyronine, T3) regulation of the Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) alpha- and beta-subunit expression in skeletal muscle, which expresses alpha 1-, alpha 2-, beta 1-, and beta 2-subunits, and compare it with that seen in kidney, which expresses only alpha 1 and beta 1.	Triiodothyronine	75-91	adrenoceptor alpha 1D	Homo sapiens	241-280
8214025-1	1993	The purpose of this study was to determine the pattern of thyroid hormone (triiodothyronine, T3) regulation of the Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) alpha- and beta-subunit expression in skeletal muscle, which expresses alpha 1-, alpha 2-, beta 1-, and beta 2-subunits, and compare it with that seen in kidney, which expresses only alpha 1 and beta 1.	Triiodothyronine	75-91	adrenoceptor alpha 1D	Homo sapiens	353-371
8260484-8	1993	Thyroxin and triiodothyronine in both free and combined forms were all correlated with thyroxin-binding globulin which in turn was negatively correlated with the triad retinol, RBP and TTR.	Triiodothyronine	13-29	retinol binding protein 4	Homo sapiens	177-180
8260484-8	1993	Thyroxin and triiodothyronine in both free and combined forms were all correlated with thyroxin-binding globulin which in turn was negatively correlated with the triad retinol, RBP and TTR.	Triiodothyronine	13-29	transthyretin	Homo sapiens	185-188
8365370-1	1993	Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3.	Triiodothyronine	262-266	apolipoprotein E	Homo sapiens	0-16
8365370-1	1993	Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3.	Triiodothyronine	262-266	apolipoprotein E	Homo sapiens	18-22
8360262-1	1993	Triiodothyronine (T3) dependent growth of GH1 rat pituitary tumor cells in serum-free defined culture requires apotransferrin (apoTf) (Sirbasku et al.	Triiodothyronine	0-16	growth hormone 1	Rattus norvegicus	42-45
8360262-1	1993	Triiodothyronine (T3) dependent growth of GH1 rat pituitary tumor cells in serum-free defined culture requires apotransferrin (apoTf) (Sirbasku et al.	Triiodothyronine	18-20	growth hormone 1	Rattus norvegicus	42-45
8102096-1	1993	The S14 gene encodes a protein found in the nuclei of lipogenic tissues that is induced synergistically by thyroid hormone (T3) and dietary carbohydrate, as are several lipogenic enzymes.	Triiodothyronine	124-126	thyroid hormone responsive	Rattus norvegicus	4-7
8345811-4	1993	The in vitro effects of triiodothyronine (T3) and T4 on the release of BNP were examined in newborn rat atrial and ventricular myocytes in primary culture.	Triiodothyronine	42-44	natriuretic peptide B	Rattus norvegicus	71-74
8227976-1	1993	Selenium is a trace element essential for the activity of type I 5"-deiodinase which converts thyroxine (T4) to 3,5,3"-triiodothyronine (T3).	Triiodothyronine	137-139	iodothyronine deiodinase 1	Homo sapiens	58-78
8320266-0	1993	Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation.	Triiodothyronine	26-43	neurotrophin 3	Rattus norvegicus	0-14
8413850-3	1993	The stimulatory effect of TRH on TSH release from monocytes is totally blocked by triiodothyronine (T3) administrations.	Triiodothyronine	82-98	thyrotropin releasing hormone	Homo sapiens	26-29
8413850-3	1993	The stimulatory effect of TRH on TSH release from monocytes is totally blocked by triiodothyronine (T3) administrations.	Triiodothyronine	100-102	thyrotropin releasing hormone	Homo sapiens	26-29
8329208-0	1993	Administration of 3,5,3"-triiodothyronine induces a rapid increase in enterocyte lactase-phlorizin hydrolase activity of young pigs on a low energy intake.	Triiodothyronine	18-41	lactase phlorizin hydrolase	Sus scrofa	81-108
8354961-2	1993	In order to understand the molecular mechanism by which thyroid hormone regulates HTGL activity, effects of triiodothyronine (T3) on HTGL activity, mRNA level, transcription run-on activity, and protein synthetic rate were studied in HepG2 cells.	Triiodothyronine	126-128	lipase C, hepatic type	Homo sapiens	133-137
8003713-0	1993	Epidermal growth factor and prolactin in rat anterior pituitary after chronic treatment with estradiol and triiodothyronine.	Triiodothyronine	107-123	epidermal growth factor like 1	Rattus norvegicus	0-23
8003713-0	1993	Epidermal growth factor and prolactin in rat anterior pituitary after chronic treatment with estradiol and triiodothyronine.	Triiodothyronine	107-123	prolactin	Rattus norvegicus	28-37
8514853-4	1993	These mutations are clustered in two regions of the T3 binding domain of the TR beta (codons 310-347 and 417-453).	Triiodothyronine	52-54	T cell receptor alpha locus	Homo sapiens	77-84
8329208-1	1993	The rapid increase in plasma concentration of 3,5,3"-triiodothyronine (T3) which occurs after feeding may invoke changes in lactase-phlorizin hydrolase (LPH) activity of the small intestine.	Triiodothyronine	46-69	lactase phlorizin hydrolase	Sus scrofa	124-151
8329208-1	1993	The rapid increase in plasma concentration of 3,5,3"-triiodothyronine (T3) which occurs after feeding may invoke changes in lactase-phlorizin hydrolase (LPH) activity of the small intestine.	Triiodothyronine	46-69	lactase phlorizin hydrolase	Sus scrofa	153-156
8329208-1	1993	The rapid increase in plasma concentration of 3,5,3"-triiodothyronine (T3) which occurs after feeding may invoke changes in lactase-phlorizin hydrolase (LPH) activity of the small intestine.	Triiodothyronine	71-73	lactase phlorizin hydrolase	Sus scrofa	124-151
8329208-1	1993	The rapid increase in plasma concentration of 3,5,3"-triiodothyronine (T3) which occurs after feeding may invoke changes in lactase-phlorizin hydrolase (LPH) activity of the small intestine.	Triiodothyronine	71-73	lactase phlorizin hydrolase	Sus scrofa	153-156
8479953-7	1993	Long-term pretreatment of adipocytes with a combination of T3 and GH produced a similar increase in lipolysis with .3 ng GLU/mL as pretreatment with either T3 or GH alone.	Triiodothyronine	156-158	growth hormone 1	Homo sapiens	66-68
8492068-0	1993	Interaction between insulin and thyroid hormone in rat pituitary tumour cells: insulin attenuates tri-iodothyronine-induced growth hormone mRNA levels.	Triiodothyronine	98-115	gonadotropin releasing hormone receptor	Rattus norvegicus	124-138
8384307-10	1993	Studies using known heterodimerization partners of RXR beta confirmed that RXR beta/triiodothyronine receptor alpha heterodimers avidly bind the ERE but revealed the existence of another triiodothyronine-independent pathway of ERE inhibition.	Triiodothyronine	84-100	retinoid X receptor beta	Homo sapiens	51-59
8384307-10	1993	Studies using known heterodimerization partners of RXR beta confirmed that RXR beta/triiodothyronine receptor alpha heterodimers avidly bind the ERE but revealed the existence of another triiodothyronine-independent pathway of ERE inhibition.	Triiodothyronine	84-100	retinoid X receptor beta	Homo sapiens	75-83
8479953-7	1993	Long-term pretreatment of adipocytes with a combination of T3 and GH produced a similar increase in lipolysis with .3 ng GLU/mL as pretreatment with either T3 or GH alone.	Triiodothyronine	59-61	growth hormone 1	Homo sapiens	162-164
8456114-6	1993	The presence, compared with the absence, of triiodothyronine in the medium supplement improved insulin responsiveness of TG synthesis.	Triiodothyronine	44-60	insulin	Gallus gallus	95-102
8473826-0	1993	The role of thyroidal type-I iodothyronine deiodinase in tri-iodothyronine production by human and sheep thyrocytes in primary culture.	Triiodothyronine	57-74	iodothyronine deiodinase 1	Homo sapiens	22-53
8384535-9	1993	This base substitution resulted in more than a four-fold decrease in T3-binding affinity for the hTR beta 1 receptor.	Triiodothyronine	69-71	T cell receptor alpha locus	Homo sapiens	97-105
8387038-1	1993	We recently reported that triiodothyronine (T3) enhances MyoD gene expression and accelerates terminal differentiation in murine C2 myoblasts.	Triiodothyronine	26-42	myogenic differentiation 1	Mus musculus	57-61
8387038-1	1993	We recently reported that triiodothyronine (T3) enhances MyoD gene expression and accelerates terminal differentiation in murine C2 myoblasts.	Triiodothyronine	44-46	myogenic differentiation 1	Mus musculus	57-61
8287830-2	1993	Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels.	Triiodothyronine	121-123	von Willebrand factor	Homo sapiens	7-10
7916684-8	1993	It is therefore significant that exposure of pre-metamorphic tadpoles (at stages before endogenous thyroid hormone secretion) to exogenous hormone (1 nM triiodothyronine) precociously activated the L-arginase gene.	Triiodothyronine	153-169	arginase-1	Xenopus laevis	198-208
8487658-0	1993	Influence of calmodulin antagonists and calcium channel blockers on triiodothyronine uptake by rat hepatoma and myoblast cell lines.	Triiodothyronine	68-84	calmodulin 1	Rattus norvegicus	13-23
8097029-1	1993	Correlation with the effect of L-3,5,3"-triiodothyronine on glutamine synthetase mRNAs.	Triiodothyronine	31-56	glutamate-ammonia ligase	Homo sapiens	60-80
8429259-5	1993	After a single receptor-saturating dose of triiodothyronine (3 mg/100 g body weight), apoA-IV gene transcription increased at 20 min and reached a maximum of 260% of control at 6 h. Increases of transcription were reflected in increases of nuclear and total apoA-IV mRNA levels.	Triiodothyronine	43-59	apolipoprotein A4	Rattus norvegicus	86-93
8429259-5	1993	After a single receptor-saturating dose of triiodothyronine (3 mg/100 g body weight), apoA-IV gene transcription increased at 20 min and reached a maximum of 260% of control at 6 h. Increases of transcription were reflected in increases of nuclear and total apoA-IV mRNA levels.	Triiodothyronine	43-59	apolipoprotein A4	Rattus norvegicus	258-265
8287830-2	1993	Plasma VWF:Ag levels in 35 hyperthyroid patients were significantly elevated, which had a positive correlation with both T3 (Triiodothyronine) and T4 (Thyroxine) levels.	Triiodothyronine	125-141	von Willebrand factor	Homo sapiens	7-10
1482352-1	1992	Type I iodothyronine deiodinase (ID-I) is a selenoenzyme, which is important for the conversion of the prohormone thyroxine (T4) to the bioactive thyroid hormone 3,3",5-triiodothyronine (T3).	Triiodothyronine	187-189	iodothyronine deiodinase 1	Rattus norvegicus	0-31
1490587-3	1992	Triiodothyronine (T3) (64 nM) reduced both the TRH- and mGnRH-stimulated release of bioactive TSH; the response of TSH to TRH even decreased toward basal levels while a significant TSH response to mGnRH remained.	Triiodothyronine	0-16	thyrotropin releasing hormone	Homo sapiens	47-50
1466661-5	1992	After a single receptor saturating dose of L-triiodothyronine (T3) apo A-II gene transcription was transiently increased to 164% +/- 13% of basal values (P < 0.05) without affecting nuclear apo A-II RNA abundance.	Triiodothyronine	43-61	apolipoprotein A2	Rattus norvegicus	67-75
1490587-3	1992	Triiodothyronine (T3) (64 nM) reduced both the TRH- and mGnRH-stimulated release of bioactive TSH; the response of TSH to TRH even decreased toward basal levels while a significant TSH response to mGnRH remained.	Triiodothyronine	18-20	thyrotropin releasing hormone	Homo sapiens	47-50
1490587-3	1992	Triiodothyronine (T3) (64 nM) reduced both the TRH- and mGnRH-stimulated release of bioactive TSH; the response of TSH to TRH even decreased toward basal levels while a significant TSH response to mGnRH remained.	Triiodothyronine	18-20	thyrotropin releasing hormone	Homo sapiens	122-125
1307382-12	1992	Both triiodothyronine (T3) and thyroxine (T4) were correlated with IGF-I in maternal serum (P < 0.05), but not in fetal serum.	Triiodothyronine	5-21	insulin-like growth factor I	Cavia porcellus	67-72
1307382-12	1992	Both triiodothyronine (T3) and thyroxine (T4) were correlated with IGF-I in maternal serum (P < 0.05), but not in fetal serum.	Triiodothyronine	23-25	insulin-like growth factor I	Cavia porcellus	67-72
1301393-2	1992	Triiodothyronine (T3) treatment of 2-day-old euthyroid rats induced a precocious stimulation of SERCA1 mRNA levels, indicating that T3 is the determining factor in the stimulation of SERCA1 message levels and that this stimulation underlies the previously reported effect of the thyroid status on the neonatal development of SR Ca(2+)-ATPase activity.	Triiodothyronine	0-16	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	183-189
1301393-2	1992	Triiodothyronine (T3) treatment of 2-day-old euthyroid rats induced a precocious stimulation of SERCA1 mRNA levels, indicating that T3 is the determining factor in the stimulation of SERCA1 message levels and that this stimulation underlies the previously reported effect of the thyroid status on the neonatal development of SR Ca(2+)-ATPase activity.	Triiodothyronine	18-20	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	96-102
1301393-2	1992	Triiodothyronine (T3) treatment of 2-day-old euthyroid rats induced a precocious stimulation of SERCA1 mRNA levels, indicating that T3 is the determining factor in the stimulation of SERCA1 message levels and that this stimulation underlies the previously reported effect of the thyroid status on the neonatal development of SR Ca(2+)-ATPase activity.	Triiodothyronine	0-16	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	96-102
1301393-2	1992	Triiodothyronine (T3) treatment of 2-day-old euthyroid rats induced a precocious stimulation of SERCA1 mRNA levels, indicating that T3 is the determining factor in the stimulation of SERCA1 message levels and that this stimulation underlies the previously reported effect of the thyroid status on the neonatal development of SR Ca(2+)-ATPase activity.	Triiodothyronine	18-20	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	183-189
1426237-1	1992	N"-Methylnicotinamide and nicotinamide, which decreased in vitro ADP-ribosylation of nuclear proteins and/or cellular NAD+ content, selectively increased the basal expression of the rat growth hormone (GH) gene promoter and its response to triiodothyronine (T3).	Triiodothyronine	240-256	gonadotropin releasing hormone receptor	Rattus norvegicus	186-200
1331079-0	1992	Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA.	Triiodothyronine	0-16	retinoic acid receptor alpha	Homo sapiens	57-79
1331079-0	1992	Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA.	Triiodothyronine	0-16	retinoid X receptor alpha	Homo sapiens	96-115
1331079-0	1992	Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA.	Triiodothyronine	18-20	retinoic acid receptor alpha	Homo sapiens	57-79
1331079-0	1992	Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA.	Triiodothyronine	18-20	retinoid X receptor alpha	Homo sapiens	96-115
1449480-1	1992	To understand the regulation by thyroid hormone, 3,3",5-triiodo-L-thyronine (T3), of the synthesis of a cytosolic thyroid hormone binding protein (p58-M2) during liver regeneration, the synthesis of p58-M2 was evaluated.	Triiodothyronine	77-79	protein disulfide isomerase family A, member 3	Rattus norvegicus	147-150
1426237-1	1992	N"-Methylnicotinamide and nicotinamide, which decreased in vitro ADP-ribosylation of nuclear proteins and/or cellular NAD+ content, selectively increased the basal expression of the rat growth hormone (GH) gene promoter and its response to triiodothyronine (T3).	Triiodothyronine	240-256	gonadotropin releasing hormone receptor	Rattus norvegicus	202-204
1426237-1	1992	N"-Methylnicotinamide and nicotinamide, which decreased in vitro ADP-ribosylation of nuclear proteins and/or cellular NAD+ content, selectively increased the basal expression of the rat growth hormone (GH) gene promoter and its response to triiodothyronine (T3).	Triiodothyronine	258-260	gonadotropin releasing hormone receptor	Rattus norvegicus	186-200
1426237-1	1992	N"-Methylnicotinamide and nicotinamide, which decreased in vitro ADP-ribosylation of nuclear proteins and/or cellular NAD+ content, selectively increased the basal expression of the rat growth hormone (GH) gene promoter and its response to triiodothyronine (T3).	Triiodothyronine	258-260	gonadotropin releasing hormone receptor	Rattus norvegicus	202-204
1443425-0	1992	Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) in abstinent male alcoholics.	Triiodothyronine	43-59	thyrotropin releasing hormone	Homo sapiens	97-126
1430208-1	1992	Generalized resistance to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant inheritance.	Triiodothyronine	85-101	thyroid hormone receptor beta	Homo sapiens	43-47
1430208-1	1992	Generalized resistance to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant inheritance.	Triiodothyronine	103-105	thyroid hormone receptor beta	Homo sapiens	43-47
1445309-0	1992	Heat stress of cultured GC cells enhances triiodothyronine-induced growth hormone production by action within the 5"-flanking region of the rat growth hormone gene.	Triiodothyronine	42-58	gonadotropin releasing hormone receptor	Rattus norvegicus	67-81
1445309-0	1992	Heat stress of cultured GC cells enhances triiodothyronine-induced growth hormone production by action within the 5"-flanking region of the rat growth hormone gene.	Triiodothyronine	42-58	gonadotropin releasing hormone receptor	Rattus norvegicus	144-158
1445309-2	1992	The effect of incubation of the clone containing pGHXGPT at 41 C was to enhance triiodothyronine induction of growth hormone secretion (2-fold, p < 0.01) and of xanthine quanine phosphoribosyl-transferase activity (3-fold, p < 0.01).	Triiodothyronine	80-96	gonadotropin releasing hormone receptor	Rattus norvegicus	110-124
1445309-3	1992	We conclude that the increase in triiodothyronine-induced growth hormone production during heat stress occurs by stimulation of the growth hormone promoter.	Triiodothyronine	33-49	gonadotropin releasing hormone receptor	Rattus norvegicus	58-72
1445309-3	1992	We conclude that the increase in triiodothyronine-induced growth hormone production during heat stress occurs by stimulation of the growth hormone promoter.	Triiodothyronine	33-49	gonadotropin releasing hormone receptor	Rattus norvegicus	132-146
1443425-0	1992	Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) in abstinent male alcoholics.	Triiodothyronine	43-59	thyrotropin releasing hormone	Homo sapiens	128-131
1443425-1	1992	Disturbances in the hypothalamic-pituitary-thyroid (HPT) axis have been reported in abstinent, noncirrhotic alcoholics, including a reduction in thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) and reductions in triiodothyronine (T3).	Triiodothyronine	229-245	thyrotropin releasing hormone	Homo sapiens	175-204
1443425-1	1992	Disturbances in the hypothalamic-pituitary-thyroid (HPT) axis have been reported in abstinent, noncirrhotic alcoholics, including a reduction in thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) and reductions in triiodothyronine (T3).	Triiodothyronine	247-249	thyrotropin releasing hormone	Homo sapiens	175-204
1418384-3	1992	In an attempt to elucidate the mechanisms controlling this phenomenon, we used Northern analysis to investigate the effect of corticosterone and thyroid hormones (tri-iodothyronine and tetra-iodothyronine) on hepatic IGF-II mRNA levels.	Triiodothyronine	163-180	insulin-like growth factor 2	Rattus norvegicus	217-223
1418384-4	1992	The administration of either corticosterone or tri-iodothyronine to 8-day-old pups resulted in a significant decrease in IGF-II mRNA when the animals were examined on day 12 of life.	Triiodothyronine	47-64	insulin-like growth factor 2	Rattus norvegicus	121-127
1324411-1	1992	Human placental lactogen B (hCS-B) promoter activity is strongly stimulated by triiodothyronine (T3) in pituitary GC cells through interaction between the thyroid receptor and a thyroid receptor-binding element (TBE) spanning coordinates -67 to -41.	Triiodothyronine	79-95	chorionic somatomammotropin hormone 2	Homo sapiens	28-33
1475013-6	1992	In perifused aggregate cell cultures of 15- to 20-day-old female rat pituitary maintained in serum-free medium supplemented with dexamethasone (DEX) and triiodothyronine (T3), AII stimulated GH release.	Triiodothyronine	153-169	angiotensinogen	Rattus norvegicus	176-179
1527000-1	1992	We have previously identified a 57-bp DNA fragment encompassing exon 1 of the beta-subunit gene of rat thyrotropin (rTSH beta) that mediates the negative response to L-triiodothyronine (T3).	Triiodothyronine	166-184	thyroid stimulating hormone subunit beta	Rattus norvegicus	116-125
1527000-1	1992	We have previously identified a 57-bp DNA fragment encompassing exon 1 of the beta-subunit gene of rat thyrotropin (rTSH beta) that mediates the negative response to L-triiodothyronine (T3).	Triiodothyronine	186-188	thyroid stimulating hormone subunit beta	Rattus norvegicus	116-125
1475013-14	1992	The effect of LHRH on GH release in aggregates cultured either in serum-free medium supplemented with DEX and T3 or in serum-supplemented medium was not affected by (Sar1,Ala8)AII, not even after enhancing the LHRH-induced GH release by treatment of the aggregates with pertussis toxin.	Triiodothyronine	110-112	gonadotropin releasing hormone 1	Rattus norvegicus	14-18
1324411-1	1992	Human placental lactogen B (hCS-B) promoter activity is strongly stimulated by triiodothyronine (T3) in pituitary GC cells through interaction between the thyroid receptor and a thyroid receptor-binding element (TBE) spanning coordinates -67 to -41.	Triiodothyronine	97-99	chorionic somatomammotropin hormone 2	Homo sapiens	28-33
1515456-2	1992	In 1989, a variant TBG was reported with reduced binding affinity for thyroxine (T4) and triiodothyronine (T3) which results in low serum T4 and T3 levels.	Triiodothyronine	89-105	serpin family A member 7	Homo sapiens	19-22
1515456-2	1992	In 1989, a variant TBG was reported with reduced binding affinity for thyroxine (T4) and triiodothyronine (T3) which results in low serum T4 and T3 levels.	Triiodothyronine	107-109	serpin family A member 7	Homo sapiens	19-22
1379237-5	1992	Moreover, the deletion of sequences outside of the receptor footprinted region (MBP-TRE-18) resulted in a higher triiodothyronine responsiveness and a concomitant increase in receptor-dependent, hormone-independent repression.	Triiodothyronine	113-129	myelin basic protein	Homo sapiens	80-83
1324733-0	1992	Stimulation of the activity and mRNA level of hepatic triacylglycerol lipase by triiodothyronine in HepG2 cells.	Triiodothyronine	80-96	lipase C, hepatic type	Homo sapiens	46-76
1324733-1	1992	We have studied the effects of triiodothyronine (T3) on the production of hepatic triacylglycerol lipase (HTGL) in the human hepatocellular carcinoma cell line, HepG2, by measuring its activity and mRNA levels.	Triiodothyronine	31-47	lipase C, hepatic type	Homo sapiens	74-104
1324733-1	1992	We have studied the effects of triiodothyronine (T3) on the production of hepatic triacylglycerol lipase (HTGL) in the human hepatocellular carcinoma cell line, HepG2, by measuring its activity and mRNA levels.	Triiodothyronine	31-47	lipase C, hepatic type	Homo sapiens	106-110
1324733-1	1992	We have studied the effects of triiodothyronine (T3) on the production of hepatic triacylglycerol lipase (HTGL) in the human hepatocellular carcinoma cell line, HepG2, by measuring its activity and mRNA levels.	Triiodothyronine	49-51	lipase C, hepatic type	Homo sapiens	74-104
1324733-1	1992	We have studied the effects of triiodothyronine (T3) on the production of hepatic triacylglycerol lipase (HTGL) in the human hepatocellular carcinoma cell line, HepG2, by measuring its activity and mRNA levels.	Triiodothyronine	49-51	lipase C, hepatic type	Homo sapiens	106-110
1379237-6	1992	Results of transfection assays showed that both receptors alpha and beta elicit indistinguishable triiodothyronine responses when the MBP-TRE functions as a regulator of a heterologous promoter activity.	Triiodothyronine	98-114	myelin basic protein	Homo sapiens	134-137
1321044-7	1992	A single low dose of triiodothyronine induces rapid increases in cytochrome-c1 and ANT2 mRNA species which parallel changes in the activity of the hormone-responsive malic enzyme, but are earlier than other mitochondrial biogenetic events.	Triiodothyronine	21-37	cytochrome c1	Homo sapiens	65-78
1634532-1	1992	Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture.	Triiodothyronine	36-52	fatty acid synthase	Gallus gallus	114-133
1634532-1	1992	Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture.	Triiodothyronine	54-56	fatty acid synthase	Gallus gallus	114-133
1634542-1	1992	The intact human growth hormone (hGH) gene is negatively regulated by triiodothyronine (T3) treatment in transfected rat pituitary tumor cells.	Triiodothyronine	70-86	growth hormone 1	Homo sapiens	17-31
1634542-1	1992	The intact human growth hormone (hGH) gene is negatively regulated by triiodothyronine (T3) treatment in transfected rat pituitary tumor cells.	Triiodothyronine	88-90	growth hormone 1	Homo sapiens	17-31
1446782-2	1992	Exposure of XTC-2 cells to 10(-9) M triiodothyronine (T3) for 24 h upregulated TR alpha and beta mRNAs by 2-4- and 10-40-fold, respectively.	Triiodothyronine	36-52	T cell receptor alpha locus L homeolog	Xenopus laevis	79-87
1446782-2	1992	Exposure of XTC-2 cells to 10(-9) M triiodothyronine (T3) for 24 h upregulated TR alpha and beta mRNAs by 2-4- and 10-40-fold, respectively.	Triiodothyronine	54-56	T cell receptor alpha locus L homeolog	Xenopus laevis	79-87
1323286-4	1992	The mechanisms underlying the stimulatory effect of triiodothyronine on apoB production were investigated.	Triiodothyronine	52-68	apolipoprotein B	Homo sapiens	72-76
1323286-5	1992	Triiodothyronine increased apoB mRNA levels by about 25-36% as determined by slot- and Northern-blot analysis of total RNA.	Triiodothyronine	0-16	apolipoprotein B	Homo sapiens	27-31
1323286-7	1992	Despite the 54.5-61% increase in apoB synthesis with triiodothyronine, only a 30% increase in apoB secretion was noted suggesting that part of the increase in the intracellular apoB pool may be lost by degradation.	Triiodothyronine	53-69	apolipoprotein B	Homo sapiens	33-37
1321044-7	1992	A single low dose of triiodothyronine induces rapid increases in cytochrome-c1 and ANT2 mRNA species which parallel changes in the activity of the hormone-responsive malic enzyme, but are earlier than other mitochondrial biogenetic events.	Triiodothyronine	21-37	solute carrier family 25 member 5	Homo sapiens	83-87
1322573-1	1992	Across all levels of L-triiodothyronine (L-T3) treatment, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in increased hepatic cytochrome P-450-associated activities of 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-dealkylase (EROD) and aryl hydrocarbon hydroxylase (AHH).	Triiodothyronine	21-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	253-281
1624098-4	1992	Chronic hCRF (1 microgram) administration induced 3.2- and 5.3-fold increases in whole body concentration of thyroxine (T4) and triiodothyronine (T3), respectively.	Triiodothyronine	128-144	corticotropin releasing hormone	Homo sapiens	8-12
1624098-4	1992	Chronic hCRF (1 microgram) administration induced 3.2- and 5.3-fold increases in whole body concentration of thyroxine (T4) and triiodothyronine (T3), respectively.	Triiodothyronine	146-148	corticotropin releasing hormone	Homo sapiens	8-12
1322573-1	1992	Across all levels of L-triiodothyronine (L-T3) treatment, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in increased hepatic cytochrome P-450-associated activities of 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-dealkylase (EROD) and aryl hydrocarbon hydroxylase (AHH).	Triiodothyronine	21-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	283-286
1322573-2	1992	The treatment of thyroidectomized rats with L-T3 at physiologic replacement levels in concert with TCDD produced an increase in ECOD, EROD and AHH activity above that seen with only TCDD.	Triiodothyronine	44-48	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	143-146
1322573-1	1992	Across all levels of L-triiodothyronine (L-T3) treatment, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in increased hepatic cytochrome P-450-associated activities of 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-dealkylase (EROD) and aryl hydrocarbon hydroxylase (AHH).	Triiodothyronine	41-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	253-281
1322573-1	1992	Across all levels of L-triiodothyronine (L-T3) treatment, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in increased hepatic cytochrome P-450-associated activities of 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-dealkylase (EROD) and aryl hydrocarbon hydroxylase (AHH).	Triiodothyronine	41-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	283-286
1416028-1	1992	We have shown that triiodothyronine-dependent GH1 rat pituitary cell growth in serum-free defined culture required apotransferrin (apoTf) (D. A. Sirbasku, et al., Biochemistry 30, 295-304, 7466-7477, 1991).	Triiodothyronine	19-35	growth hormone 1	Rattus norvegicus	46-49
1377854-0	1992	Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	33-67
1586154-0	1992	Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine.	Triiodothyronine	157-173	fatty acid synthase	Gallus gallus	35-54
1599938-1	1992	The type I iodothyronine deiodinase (ID-I) of liver is an important enzyme for the conversion of the prohormone thyroxine (T4) to the active thyroid hormone 3,3",5-triiodothyronine (T3).	Triiodothyronine	182-184	iodothyronine deiodinase 1	Rattus norvegicus	4-35
1377854-0	1992	Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro.	Triiodothyronine	18-20	insulin-like growth factor 1	Rattus norvegicus	33-67
1517706-0	1992	Effect of administration of growth hormone on plasma and intracellular levels of thyroxine and tri-iodothyronine in thyroidectomized thyroxine-treated rats.	Triiodothyronine	95-112	gonadotropin releasing hormone receptor	Rattus norvegicus	28-42
1374352-9	1992	Since we have shown that thyroid hormone (T3) induces 63-kDa keratin gene expression and hydrocortisone (HC) modulates T3 action we examined the effects of T3 and HC at the single cell level with the anti-keratin antibody.	Triiodothyronine	42-44	70a	Xenopus laevis	61-68
1564567-6	1992	The activities of carbamylphosphate, synthetase, ornithine aminotransferase and ornithine decarboxylase in liver of the group treated with 6-propyl-2-thiouracil alone were significantly lower than those of the 6-propyl-2-thiouracil plus triiodothyronine-treated group.	Triiodothyronine	237-253	ornithine decarboxylase 1	Rattus norvegicus	80-103
1572297-0	1992	Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine.	Triiodothyronine	136-152	thyrotropin releasing hormone	Rattus norvegicus	0-29
1572297-3	1992	The concentration of pro-TRH mRNA in the PVN of hypothyroid male rats receiving constant infusions of T3 over 7 days from ip implanted osmotic minipumps was studied by in situ hybridization histochemistry using computerized image analysis.	Triiodothyronine	102-104	thyrotropin releasing hormone	Rattus norvegicus	21-28
1355453-0	1992	Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine.	Triiodothyronine	150-167	gamma-glutamyltransferase 1	Rattus norvegicus	39-67
1355453-10	1992	Treatment of diethylnitrosamine-injected young immature male Fischer 344 rats at the prenodular phase of hepatic premalignancy with tri-iodothyronine at 0.005 micrograms/kg s.c. daily for 7 days reversed the diethylnitrosamine-induced increase in liver homogenate gamma-glutamyltranspeptidase activity and the decrease in plasma total T3, restoring these parameters to normal levels.	Triiodothyronine	132-149	gamma-glutamyltransferase 1	Rattus norvegicus	264-292
1531344-1	1992	We examined changes in the expression of fibronectin during the induction of cardiac hypertrophy by L-triiodothyronine administration and by mineralocorticoid- and salt-induced experimental hypertension.	Triiodothyronine	100-118	fibronectin 1	Rattus norvegicus	41-52
1733706-0	1992	Additive and/or synergistic effects of 5 alpha-dihydrotestosterone, dexamethasone, and triiodo-L-thyronine on induction of proteinases and epidermal growth factor in the submandibular gland of hypophysectomized mice.	Triiodothyronine	87-106	epidermal growth factor	Mus musculus	139-162
1371278-3	1992	Thyroid hormone (T3) stimulated the activity of the rat and human OT promoters about 10-fold.	Triiodothyronine	17-19	oxytocin/neurophysin I prepropeptide	Homo sapiens	66-68
1531344-4	1992	During the progression of cardiac hypertrophy induced by L-triiodothyronine over a 10-d period, there was a progressive increase in fibronectin mRNA for the first 6 d followed by a return to control levels.	Triiodothyronine	57-75	fibronectin 1	Rattus norvegicus	132-143
1310350-4	1992	RXR alpha interacts both with TRs and with RARs, forming heterodimers in solution that strongly interact with a variety of T3/retinoic acid response elements.	Triiodothyronine	123-126	retinoid X receptor alpha	Homo sapiens	0-9
1569376-4	1992	The increases in LPL activity and mass were reversed by treatment of hypothyroid rats with triiodothyronine (T3).	Triiodothyronine	91-107	lipoprotein lipase	Rattus norvegicus	17-20
1569376-4	1992	The increases in LPL activity and mass were reversed by treatment of hypothyroid rats with triiodothyronine (T3).	Triiodothyronine	109-111	lipoprotein lipase	Rattus norvegicus	17-20
1543680-6	1992	Treatment of rats with 3,3",5-triiodo-L-thyronine (T3), but not reverse T3 (rT3) (the predominant form present in fetal serum), enhanced CBG biosynthesis.	Triiodothyronine	23-49	serpin family A member 6	Rattus norvegicus	137-140
1543680-6	1992	Treatment of rats with 3,3",5-triiodo-L-thyronine (T3), but not reverse T3 (rT3) (the predominant form present in fetal serum), enhanced CBG biosynthesis.	Triiodothyronine	51-53	serpin family A member 6	Rattus norvegicus	137-140
1730237-7	1992	Triiodothyronine overexpressed the Glc6P dehydrogenase mRNA induced by the presence of insulin at 6 d and 10 d of culture.	Triiodothyronine	0-16	insulin	Homo sapiens	87-94
1730680-2	1992	Triiodothyronine (T3) induces the transcription of the human chorionic somatomammotropin (hCS) promoter transfected into rat pituitary (GC) cells, but does not stimulate the homologous human growth hormone (hGH) promoter.	Triiodothyronine	0-16	holocarboxylase synthetase	Homo sapiens	90-93
1730680-2	1992	Triiodothyronine (T3) induces the transcription of the human chorionic somatomammotropin (hCS) promoter transfected into rat pituitary (GC) cells, but does not stimulate the homologous human growth hormone (hGH) promoter.	Triiodothyronine	18-20	holocarboxylase synthetase	Homo sapiens	90-93
1733251-4	1992	Results in hypothyroid rats given 3,5,3"-triiodothyronine (T3) and in dispersed brown adipocytes show that T3 is involved both in the increase in UCP mRNA precursor level and stabilization of mature UCP mRNA.	Triiodothyronine	34-57	uncoupling protein 1	Rattus norvegicus	146-149
1370444-3	1992	Due to the essential role of thyroid hormone for a correct brain development, we have now investigated the possible regulation by 3,5,3"-triiodo-L-thyronine (T3) of NGFI-A gene expression during maturation of the central nervous system.	Triiodothyronine	130-156	early growth response 1	Rattus norvegicus	165-171
1370444-3	1992	Due to the essential role of thyroid hormone for a correct brain development, we have now investigated the possible regulation by 3,5,3"-triiodo-L-thyronine (T3) of NGFI-A gene expression during maturation of the central nervous system.	Triiodothyronine	158-160	early growth response 1	Rattus norvegicus	165-171
1415375-1	1992	The effect of triiodothyronine (T3) on the responses to mitogens and on the production of prostaglandin E2 and interleukin 2 were studied in serum-free cultures of peripheral blood mononuclear cells (PBMC) in 20 patients undergoing hemodialysis and in 30 control subjects.	Triiodothyronine	32-34	interleukin 2	Homo sapiens	111-124
18647708-3	1992	An eventual influence of aging on triiodothyronine (T(3))-induced subpopulation response is also worth studying, because of the decrease of receptor density in old animals observed only in the beta1-type.	Triiodothyronine	34-50	hemoglobin, beta adult major chain	Mus musculus	193-198
1425022-3	1992	The increase in TRH mRNA can be obliterated by stereotaxic implants of hormonally active L-triiodothyronine (T3) placed into the anterior hypothalamus but not by implants of the hormonally inactive 3,5"-diiodo-L-thyronine (T2); we therefore suggested that T3 has a direct action on TRH-containing cells of the PVN.	Triiodothyronine	89-107	thyrotropin releasing hormone	Homo sapiens	16-19
1425022-3	1992	The increase in TRH mRNA can be obliterated by stereotaxic implants of hormonally active L-triiodothyronine (T3) placed into the anterior hypothalamus but not by implants of the hormonally inactive 3,5"-diiodo-L-thyronine (T2); we therefore suggested that T3 has a direct action on TRH-containing cells of the PVN.	Triiodothyronine	89-107	thyrotropin releasing hormone	Homo sapiens	282-285
1425022-3	1992	The increase in TRH mRNA can be obliterated by stereotaxic implants of hormonally active L-triiodothyronine (T3) placed into the anterior hypothalamus but not by implants of the hormonally inactive 3,5"-diiodo-L-thyronine (T2); we therefore suggested that T3 has a direct action on TRH-containing cells of the PVN.	Triiodothyronine	109-111	thyrotropin releasing hormone	Homo sapiens	16-19
1425022-3	1992	The increase in TRH mRNA can be obliterated by stereotaxic implants of hormonally active L-triiodothyronine (T3) placed into the anterior hypothalamus but not by implants of the hormonally inactive 3,5"-diiodo-L-thyronine (T2); we therefore suggested that T3 has a direct action on TRH-containing cells of the PVN.	Triiodothyronine	109-111	thyrotropin releasing hormone	Homo sapiens	282-285
18647708-3	1992	An eventual influence of aging on triiodothyronine (T(3))-induced subpopulation response is also worth studying, because of the decrease of receptor density in old animals observed only in the beta1-type.	Triiodothyronine	52-57	hemoglobin, beta adult major chain	Mus musculus	193-198
1292932-3	1992	The results showed that 5"-nucleotidase is modified when the rats received injections of 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	89-115	5' nucleotidase, ecto	Rattus norvegicus	24-39
1292932-3	1992	The results showed that 5"-nucleotidase is modified when the rats received injections of 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	117-119	5' nucleotidase, ecto	Rattus norvegicus	24-39
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	145-161	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	145-161	gonadotropin releasing hormone receptor	Rattus norvegicus	16-18
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	145-161	growth hormone 1	Rattus norvegicus	34-37
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	163-165	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	163-165	gonadotropin releasing hormone receptor	Rattus norvegicus	16-18
1730572-1	1992	Growth hormone (GH) production by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium requires apotransferrin (apoTf) and triiodothyronine (T3).	Triiodothyronine	163-165	growth hormone 1	Rattus norvegicus	34-37
1917977-0	1991	Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine.	Triiodothyronine	96-112	fatty acid synthase	Mus musculus	32-51
1738433-4	1992	Furthermore, in vitro pre-treatment of anterior pituitaries with triiodothyronine (T3) produced a dose-dependent decrease in both TSH secretion and the formation of [3H]IP in response to TRH.	Triiodothyronine	65-81	thyrotropin releasing hormone	Rattus norvegicus	187-190
1738433-4	1992	Furthermore, in vitro pre-treatment of anterior pituitaries with triiodothyronine (T3) produced a dose-dependent decrease in both TSH secretion and the formation of [3H]IP in response to TRH.	Triiodothyronine	83-85	thyrotropin releasing hormone	Rattus norvegicus	187-190
1641616-4	1992	Favorable for a high milk yield are high circulating concentrations of somatotropin, possibly associated with increased production and levels of the insulin-like growth factor I, in the presence of low concentrations of and reduced sensitivity or responsiveness of target organs to insulin, reduced circulating levels of thyroid hormones and possibly enhanced conversion of thyroxine to triiodothyronine in the mammary gland.	Triiodothyronine	387-403	somatotropin	Bos taurus	71-83
1795446-1	1991	A case of symptomatic hypobetalipoproteinemia (hypo-beta LP) with unusual distribution of apolipoprotein E (apo E) in a 68-year-old male patient with chronic heart failure and liver cirrhosis associated with low triiodothyronine (T3) syndrome is reported.	Triiodothyronine	212-228	apolipoprotein E	Homo sapiens	108-113
1795446-1	1991	A case of symptomatic hypobetalipoproteinemia (hypo-beta LP) with unusual distribution of apolipoprotein E (apo E) in a 68-year-old male patient with chronic heart failure and liver cirrhosis associated with low triiodothyronine (T3) syndrome is reported.	Triiodothyronine	230-232	apolipoprotein E	Homo sapiens	108-113
1351482-8	1992	Triiodothyronine markedly enhanced malic enzyme mRNA induction by insulin with dexamethasone, and tended to enhance the induction of the acetyl-CoA carboxylase and fatty acid synthase mRNAs, but not that of glucose 6-phosphate dehydrogenase mRNA.	Triiodothyronine	0-16	fatty acid synthase	Rattus norvegicus	164-183
1725515-0	1991	Triiodothyronine (T3) inhibition of growth hormone secretion by chicken pituitary cells in vitro.	Triiodothyronine	0-16	growth hormone	Gallus gallus	36-50
1725515-0	1991	Triiodothyronine (T3) inhibition of growth hormone secretion by chicken pituitary cells in vitro.	Triiodothyronine	18-20	growth hormone	Gallus gallus	36-50
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	72-88	growth hormone	Gallus gallus	97-111
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	72-88	growth hormone	Gallus gallus	142-156
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	72-88	growth hormone	Gallus gallus	158-160
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	90-92	growth hormone	Gallus gallus	97-111
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	90-92	growth hormone	Gallus gallus	142-156
1725515-1	1991	These studies examined the cellular basis for the inhibitory effects of triiodothyronine (T3) on growth hormone-releasing factor (GRF)-evoked growth hormone (GH) release from chicken anterior pituitary cells in vitro.	Triiodothyronine	90-92	growth hormone	Gallus gallus	158-160
1725515-5	1991	Triiodothyronine reduced (P less than 0.05) GH release (ng/ml) in response to (1) GRF; (2) the adenylyl cyclase stimulator, forskolin; (3) the cAMP analog and protein kinase A activator, 8-bromo cAMP; and (4) the phorbol ester and protein kinase C activator, phorbol 12-myristate 13-acetate.	Triiodothyronine	0-16	growth hormone	Gallus gallus	44-46
1725515-6	1991	Triiodothyronine reduced (P less than 0.05) the intracellular content of GH and total GH (released GH and intracellular GH) irrespectively of whether secretagogues were also present.	Triiodothyronine	0-16	growth hormone	Gallus gallus	73-75
1725515-6	1991	Triiodothyronine reduced (P less than 0.05) the intracellular content of GH and total GH (released GH and intracellular GH) irrespectively of whether secretagogues were also present.	Triiodothyronine	0-16	growth hormone	Gallus gallus	86-88
1725515-6	1991	Triiodothyronine reduced (P less than 0.05) the intracellular content of GH and total GH (released GH and intracellular GH) irrespectively of whether secretagogues were also present.	Triiodothyronine	0-16	growth hormone	Gallus gallus	86-88
1725515-6	1991	Triiodothyronine reduced (P less than 0.05) the intracellular content of GH and total GH (released GH and intracellular GH) irrespectively of whether secretagogues were also present.	Triiodothyronine	0-16	growth hormone	Gallus gallus	86-88
1960619-4	1991	At delivery, concentrations of maternal thyrotropin were elevated in the TRH group compared with the control group (12.0 +/- 1.6 vs 5.6 +/- 0.5 mU/L; p less than 0.005); however, maternal triiodothyronine (T3) values remained unchanged.	Triiodothyronine	188-204	thyrotropin releasing hormone	Homo sapiens	73-76
1960619-4	1991	At delivery, concentrations of maternal thyrotropin were elevated in the TRH group compared with the control group (12.0 +/- 1.6 vs 5.6 +/- 0.5 mU/L; p less than 0.005); however, maternal triiodothyronine (T3) values remained unchanged.	Triiodothyronine	206-208	thyrotropin releasing hormone	Homo sapiens	73-76
1957562-0	1991	Effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and iodide on the thyrotropin-releasing hormone-induced thyrotropin release from superfused rat pituitary fragments.	Triiodothyronine	11-27	thyrotropin releasing hormone	Rattus norvegicus	86-115
1786707-0	1991	Effect of exogenous thyrotropin-releasing hormone (TRH) administration on plasma levels of triiodothyronine (T3), thyroxine (T4) and growth hormone (GH) in chronically catheterized suckling piglets.	Triiodothyronine	91-107	thyrotropin releasing hormone	Homo sapiens	51-54
1949040-4	1991	The induction profile of hUDP-GT-T4 for these inducers was approximately the same as that of hUDP-GT activity toward triiodothyronine (T3; hUDP-GT-T3), indicating that these two thyroid hormones (T4 and T3) are glucuronidated by the same hUDP-GT(s).	Triiodothyronine	117-133	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	93-100
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	24-40	growth hormone 1	Homo sapiens	179-181
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	42-44	thyrotropin releasing hormone	Homo sapiens	119-148
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	42-44	thyrotropin releasing hormone	Homo sapiens	150-153
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	42-44	growth hormone 1	Homo sapiens	163-177
1778404-0	1991	Effect of triiodothyronine supplementation on thyrotropin-releasing hormone-induced growth hormone secretion in sex-linked dwarf and normal chicks.	Triiodothyronine	10-26	thyrotropin releasing hormone	Homo sapiens	46-75
1778404-0	1991	Effect of triiodothyronine supplementation on thyrotropin-releasing hormone-induced growth hormone secretion in sex-linked dwarf and normal chicks.	Triiodothyronine	10-26	growth hormone 1	Homo sapiens	84-98
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	24-40	thyrotropin releasing hormone	Homo sapiens	119-148
1778404-1	1991	The effect of a dietary triiodothyronine (T3) supplement, of either 0.1 or 0.5 microgram/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf (dw) or normal (Dw) chicks of both sexes.	Triiodothyronine	24-40	thyrotropin releasing hormone	Homo sapiens	150-153
1744563-0	1991	Modulation of immunoreactive epidermal growth factor levels in the submandibular gland, pancreas, liver, kidney and gastrointestinal tract of suckling rats by cortisone and tri-iodothyronine.	Triiodothyronine	173-190	epidermal growth factor like 1	Rattus norvegicus	29-52
1744563-2	1991	The present studies evaluated the effects of two hormones known for their maturative effect on suckling rats, cortisone and tri-iodothyronine (T3), on immunoreactive EGF levels in specific organs.	Triiodothyronine	124-141	epidermal growth factor like 1	Rattus norvegicus	166-169
1744563-2	1991	The present studies evaluated the effects of two hormones known for their maturative effect on suckling rats, cortisone and tri-iodothyronine (T3), on immunoreactive EGF levels in specific organs.	Triiodothyronine	143-145	epidermal growth factor like 1	Rattus norvegicus	166-169
1943730-5	1991	In a patient with Graves" disease whose plasma thyroxine (T4) and triiodothyronine (T3) concentrations changed remarkably because of poor compliance with the regimen, the change in plasma thyroid hormone levels preceded the change in the RBC CAI and Zn concentrations by 2 to 3 months.	Triiodothyronine	66-82	carbonic anhydrase 1	Homo sapiens	242-245
1949040-4	1991	The induction profile of hUDP-GT-T4 for these inducers was approximately the same as that of hUDP-GT activity toward triiodothyronine (T3; hUDP-GT-T3), indicating that these two thyroid hormones (T4 and T3) are glucuronidated by the same hUDP-GT(s).	Triiodothyronine	117-133	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	93-100
1949040-4	1991	The induction profile of hUDP-GT-T4 for these inducers was approximately the same as that of hUDP-GT activity toward triiodothyronine (T3; hUDP-GT-T3), indicating that these two thyroid hormones (T4 and T3) are glucuronidated by the same hUDP-GT(s).	Triiodothyronine	117-133	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	93-100
1743614-0	1991	Triiodothyronine control of ATP-citrate lyase and malic enzyme during differentiation of a murine preadipocyte cell line.	Triiodothyronine	0-16	ATP citrate lyase	Mus musculus	28-45
1680129-0	1991	Triiodothyronine-induced accumulations of malic enzyme, fatty acid synthase, acetyl-coenzyme A carboxylase, and their mRNAs are blocked by protein kinase inhibitors.	Triiodothyronine	0-16	fatty acid synthase	Gallus gallus	56-75
1680129-2	1991	Addition of triiodothyronine (T3) to chick-embryo hepatocytes in culture causes increased accumulations of malic enzyme, fatty acid synthase, acetyl-CoA carboxylase and their mRNAs.	Triiodothyronine	12-28	fatty acid synthase	Gallus gallus	121-140
1680129-2	1991	Addition of triiodothyronine (T3) to chick-embryo hepatocytes in culture causes increased accumulations of malic enzyme, fatty acid synthase, acetyl-CoA carboxylase and their mRNAs.	Triiodothyronine	30-32	fatty acid synthase	Gallus gallus	121-140
1874176-4	1991	The relative rates of activity with various substrates (CoQ0 approximately equal to durohydroquinone greater than menadione greater than duroquinone greater than CoQ6 = CoQ10 greater than ferricyanide) were similar to those described previously for quinone reductase from liver Dicumarol, chlorpromazine, and T3 were much more potent inhibitors of the enzyme when NADPH was the coenzyme than when NADH was the coenzyme.	Triiodothyronine	309-311	coenzyme Q6, monooxygenase	Homo sapiens	162-166
1651924-1	1991	Exposure of ventricular myocytes in primary culture to triiodothyronine (T3) increased the number of beta 1-adrenergic receptors per cell by 2.1 +/- 0.3-fold (n = 7) within 48 h. Immunoblots of membranes prepared from myocytes revealed a marked increase by T3 in the 64-kDa species of the beta 1-adrenergic receptor.	Triiodothyronine	55-71	adrenoceptor beta 1	Homo sapiens	101-127
1955072-1	1991	We have examined the effects of triiodothyronine (T3), in dose-response and time-course studies, on T3 receptor (T3R) alpha and beta and glucocorticoid receptor (GR) mRNAs in rate pituitary GH3 cells, in parallel with T3 actions on expression of the growth hormone (GH) target gene.	Triiodothyronine	32-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	137-160
1955072-1	1991	We have examined the effects of triiodothyronine (T3), in dose-response and time-course studies, on T3 receptor (T3R) alpha and beta and glucocorticoid receptor (GR) mRNAs in rate pituitary GH3 cells, in parallel with T3 actions on expression of the growth hormone (GH) target gene.	Triiodothyronine	32-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	162-164
1955072-1	1991	We have examined the effects of triiodothyronine (T3), in dose-response and time-course studies, on T3 receptor (T3R) alpha and beta and glucocorticoid receptor (GR) mRNAs in rate pituitary GH3 cells, in parallel with T3 actions on expression of the growth hormone (GH) target gene.	Triiodothyronine	32-48	gonadotropin releasing hormone receptor	Rattus norvegicus	190-192
1651924-1	1991	Exposure of ventricular myocytes in primary culture to triiodothyronine (T3) increased the number of beta 1-adrenergic receptors per cell by 2.1 +/- 0.3-fold (n = 7) within 48 h. Immunoblots of membranes prepared from myocytes revealed a marked increase by T3 in the 64-kDa species of the beta 1-adrenergic receptor.	Triiodothyronine	73-75	adrenoceptor beta 1	Homo sapiens	101-127
1761515-8	1991	In addition, the administration of triiodothyronine stimulated HAST in hypophysectomized rats of both sexes, and the extent of stimulation was nearly the same as observed in the male-type growth hormone treatment.	Triiodothyronine	35-51	gonadotropin releasing hormone receptor	Rattus norvegicus	188-202
1802681-0	1991	Direct up-regulation of estrogen receptor by triiodothyronine in rat pituitary tumor MtT/F84.	Triiodothyronine	45-61	estrogen receptor 1	Rattus norvegicus	24-41
1802681-1	1991	To investigate a possible effect of triiodothyronine (T3) on the regulation of estrogen receptor, estrogen dependent rat pituitary tumor, MtT/F84, was studied in rats which received surgical thyroidectomy (Tx) or were given propylthiouracil (PTU) and were supplemented with T3.	Triiodothyronine	54-56	estrogen receptor 1	Rattus norvegicus	79-96
1794839-0	1991	Increase of biliary excretion of reverse triiodothyronine in rats during the infusion of neurotensin possibly resulting from the inhibition of iodothyronine 5"-monodeiodination.	Triiodothyronine	41-57	neurotensin	Rattus norvegicus	89-100
1713218-0	1991	Plasma free triiodothyronine response to thyrotropin-releasing hormone to predict the remission of Graves" disease treated with antithyroid drugs.	Triiodothyronine	12-28	thyrotropin releasing hormone	Homo sapiens	41-70
1650579-2	1991	L-Thyroxine and L-triiodothyronine elicited dose dependently a potent inhibitory action on the FMLP-induced O2- production with IC50 values of about 10(-6) M and 7.10(-6) M, respectively, but L-diiodothyronine did not.	Triiodothyronine	16-34	formyl peptide receptor 1	Homo sapiens	95-99
1919395-3	1991	In order to determine whether changes in thyroid status are associated with changes in expression of these putative intracellular signals, we examined the effect of hypothyroidism and tri-iodothyronine (T3) treatment on myocardial levels of c-myc, c-fos and H-ras mRNAs in the rat.	Triiodothyronine	184-201	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	241-246
1854723-8	1991	p58-M2 bound to 3,3",5-triiodo-L-thyronine (T3) (Ka = 1.7 x 10(7) M-1) and exhibited analogue specificity, whereas PKM2 did not bind thyroid hormone.	Triiodothyronine	44-46	pyruvate kinase M1/2	Homo sapiens	0-3
1650579-6	1991	L-Thyroxine and L-triiodothyronine were found to block [3H]FMLP binding to its own receptor with IC50 values similar to those for the inhibition of the O2- production by changing the affinity for the peptide but not the number of the receptors.	Triiodothyronine	16-34	formyl peptide receptor 1	Homo sapiens	59-63
1650579-7	1991	These results suggest that thyroxine and triiodothyronine interfere with the binding of FMLP to the receptors, leading to the inhibition of neutrophil functions, such as O2- production, and that the inhibitory effects result from extranuclear actions rather than nuclear receptor-mediated ones.	Triiodothyronine	41-57	formyl peptide receptor 1	Homo sapiens	88-92
1649730-4	1991	At rest, the fasting concentrations of insulin and pro-insulin correlated positively with the prevailing total tri-iodothyronine concentration, whereas the concentrations of noradrenaline and cortisol correlated inversely with the tri-iodothyronine concentration.	Triiodothyronine	111-128	insulin	Homo sapiens	39-46
1649730-4	1991	At rest, the fasting concentrations of insulin and pro-insulin correlated positively with the prevailing total tri-iodothyronine concentration, whereas the concentrations of noradrenaline and cortisol correlated inversely with the tri-iodothyronine concentration.	Triiodothyronine	111-128	insulin	Homo sapiens	55-62
1897967-1	1991	The modulation of hepatic and renal cysteine sulfinic acid decarboxylase (EC 4.1.1.29) activities by triiodothyronine (T3) was studied in a series of experiments.	Triiodothyronine	101-117	cysteine sulfinic acid decarboxylase	Rattus norvegicus	36-72
1675989-4	1991	At this experimental time, the activity of the NADPH generating enzyme glucose-6-phosphate dehydrogenase was enhanced by 84% in the liver of T3-treated rats, compared to that in the controls.	Triiodothyronine	141-143	glucose-6-phosphate dehydrogenase	Rattus norvegicus	71-104
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	0-16	glucose-6-phosphate dehydrogenase	Homo sapiens	154-187
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	0-16	phosphogluconate dehydrogenase	Homo sapiens	193-225
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	0-16	insulin	Homo sapiens	229-236
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	18-20	glucose-6-phosphate dehydrogenase	Homo sapiens	154-187
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	18-20	phosphogluconate dehydrogenase	Homo sapiens	193-225
1870419-0	1991	Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3.	Triiodothyronine	18-20	insulin	Homo sapiens	229-236
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	32-48	glucose-6-phosphate dehydrogenase	Homo sapiens	100-133
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	32-48	glucose-6-phosphate dehydrogenase	Homo sapiens	135-139
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	32-48	phosphogluconate dehydrogenase	Homo sapiens	146-178
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	32-48	phosphogluconate dehydrogenase	Homo sapiens	180-184
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	50-52	phosphogluconate dehydrogenase	Homo sapiens	146-178
1870419-1	1991	The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).	Triiodothyronine	50-52	phosphogluconate dehydrogenase	Homo sapiens	180-184
2064617-17	1991	Incubation of rat hepatocytes with 10 nM-tri-iodothyronine for 4 h increased the relative concentration of the mRNA for the LDL receptor by 25%.	Triiodothyronine	40-58	low density lipoprotein receptor	Rattus norvegicus	124-136
1667491-0	1991	[Effect of triiodothyronine on the expression of neuron-specific enolase activity in developing cultured human fetal cerebral neurons].	Triiodothyronine	11-27	enolase 2	Homo sapiens	49-72
2043667-0	1991	Studies on the decrease of liver cytochrome P-450 content by triiodothyronine.	Triiodothyronine	61-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
2043667-1	1991	In the rat liver, the microsomal content of cytochrome P-450 decreased by 50% after triiodothyronine (T3) administration.	Triiodothyronine	84-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
2043667-1	1991	In the rat liver, the microsomal content of cytochrome P-450 decreased by 50% after triiodothyronine (T3) administration.	Triiodothyronine	102-104	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
2043667-7	1991	It is suggested that the amount of the apocytochrome may be the primary event affected in the formation of cytochrome P-450, by triiodothyronine treatment of thyroidectomized rats.	Triiodothyronine	128-144	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	107-123
1850607-1	1991	Glucocorticoids, triiodothyronine (T3), and cyclic adenosine monophosphate (cAMP) have been shown previously to modulate phosphatidylcholine and surfactant protein A (SP-A) synthesis in fetal rat lung explant cultures.	Triiodothyronine	17-33	surfactant protein A1	Rattus norvegicus	145-165
1850607-1	1991	Glucocorticoids, triiodothyronine (T3), and cyclic adenosine monophosphate (cAMP) have been shown previously to modulate phosphatidylcholine and surfactant protein A (SP-A) synthesis in fetal rat lung explant cultures.	Triiodothyronine	17-33	surfactant protein A1	Rattus norvegicus	167-171
1850607-1	1991	Glucocorticoids, triiodothyronine (T3), and cyclic adenosine monophosphate (cAMP) have been shown previously to modulate phosphatidylcholine and surfactant protein A (SP-A) synthesis in fetal rat lung explant cultures.	Triiodothyronine	35-37	surfactant protein A1	Rattus norvegicus	145-165
1850607-1	1991	Glucocorticoids, triiodothyronine (T3), and cyclic adenosine monophosphate (cAMP) have been shown previously to modulate phosphatidylcholine and surfactant protein A (SP-A) synthesis in fetal rat lung explant cultures.	Triiodothyronine	35-37	surfactant protein A1	Rattus norvegicus	167-171
1897967-1	1991	The modulation of hepatic and renal cysteine sulfinic acid decarboxylase (EC 4.1.1.29) activities by triiodothyronine (T3) was studied in a series of experiments.	Triiodothyronine	119-121	cysteine sulfinic acid decarboxylase	Rattus norvegicus	36-72
1860972-6	1991	Somatotropin reduced plasma concentrations of triiodothyronine and cortisol and had no effect on plasma prolactin and insulin concentrations.	Triiodothyronine	46-62	somatotropin	Bos taurus	0-12
2031440-0	1991	Heat stress and hydrocortisone are independent stimulators of triiodothyronine-induced growth hormone production in cultured rat somatotrophic tumour cells.	Triiodothyronine	62-78	gonadotropin releasing hormone receptor	Rattus norvegicus	87-101
1847210-2	1991	Hyperthyroidism induced by administration of tri-iodothyronine on postnatal days 1 to 5 caused a reduction in the ability of isoproterenol to stimulate cardiac ODC but subsequently accelerated the onset of the postweaning peak of the response; the latter effect was even more prominent when tri-iodothyronine administration was given on postnatal days 14 to 18.	Triiodothyronine	45-62	ornithine decarboxylase 1	Rattus norvegicus	160-163
1820970-5	1991	In the present study, the regulation of osteocalcin synthesis by other hormones of the steroid-thyroid hormone family (retinoic acid, 17 beta-estradiol, triiodothyronine, and dexamethasone) was examined.	Triiodothyronine	153-169	bone gamma-carboxyglutamate protein	Homo sapiens	40-51
1820970-10	1991	The inhibition of osteocalcin synthesis by dexamethasone and triiodothyronine was accompanied by decreased osteocalcin mRNA levels.	Triiodothyronine	61-77	bone gamma-carboxyglutamate protein	Homo sapiens	18-29
1820970-10	1991	The inhibition of osteocalcin synthesis by dexamethasone and triiodothyronine was accompanied by decreased osteocalcin mRNA levels.	Triiodothyronine	61-77	bone gamma-carboxyglutamate protein	Homo sapiens	107-118
1899004-6	1991	3, 5, 3"-Triiodothyronine (T3) infusion in thyroidectomized fetuses resulted in elevated serum T3 values (480 +/- 80 ng/dl) and suppressed hypothalamic TRH (249 +/- 68 vs. 522 +/- 29 pg/mg protein) and serum TRH concentrations (30 +/- 4 vs. 131 +/- 156 pg/ml).	Triiodothyronine	0-25	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	152-155
1899004-6	1991	3, 5, 3"-Triiodothyronine (T3) infusion in thyroidectomized fetuses resulted in elevated serum T3 values (480 +/- 80 ng/dl) and suppressed hypothalamic TRH (249 +/- 68 vs. 522 +/- 29 pg/mg protein) and serum TRH concentrations (30 +/- 4 vs. 131 +/- 156 pg/ml).	Triiodothyronine	0-25	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	208-211
1899004-6	1991	3, 5, 3"-Triiodothyronine (T3) infusion in thyroidectomized fetuses resulted in elevated serum T3 values (480 +/- 80 ng/dl) and suppressed hypothalamic TRH (249 +/- 68 vs. 522 +/- 29 pg/mg protein) and serum TRH concentrations (30 +/- 4 vs. 131 +/- 156 pg/ml).	Triiodothyronine	27-29	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	152-155
1899004-6	1991	3, 5, 3"-Triiodothyronine (T3) infusion in thyroidectomized fetuses resulted in elevated serum T3 values (480 +/- 80 ng/dl) and suppressed hypothalamic TRH (249 +/- 68 vs. 522 +/- 29 pg/mg protein) and serum TRH concentrations (30 +/- 4 vs. 131 +/- 156 pg/ml).	Triiodothyronine	27-29	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	208-211
1727018-0	1991	The relationship between autoantibodies to triiodothyronine (T3) and thyroglobulin (Tg) in the dog.	Triiodothyronine	43-59	thyroglobulin	Canis lupus familiaris	69-82
1727018-0	1991	The relationship between autoantibodies to triiodothyronine (T3) and thyroglobulin (Tg) in the dog.	Triiodothyronine	61-63	thyroglobulin	Canis lupus familiaris	69-82
2128046-2	1990	Triiodothyronine inhibited lactase activities regardless the presence of dexamethasone.	Triiodothyronine	0-16	lactase	Rattus norvegicus	27-34
1657330-2	1991	In addition, exposure of the cells for 24h to dexamethasone, estradiol, retinoic acid, or triiodothyronine resulted in a dose-dependent accumulation of hVDR mRNA.	Triiodothyronine	90-106	vitamin D receptor	Homo sapiens	152-156
1659891-2	1991	The hormonal regulation studies of hepatic SBP mRNA demonstrate that it is controlled by estradiol, antiestrogen tamoxifen, dihydrotestosterone, triiodothyronine and insulin in a similar way as secreted SBP.	Triiodothyronine	145-161	selenium binding protein 1	Homo sapiens	43-46
2176887-7	1990	Triiodothyronine (T3) also potentiated the Bt2cAMP-mediated PEPCK gene expression but failed to increase further the induction by DEX/retinoic acid/Bt2cAMP.	Triiodothyronine	0-16	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	60-65
2176887-7	1990	Triiodothyronine (T3) also potentiated the Bt2cAMP-mediated PEPCK gene expression but failed to increase further the induction by DEX/retinoic acid/Bt2cAMP.	Triiodothyronine	18-20	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	60-65
1712719-0	1991	Degrees of cooperativity between triiodothyronine and hydrocortisone in their regulation of the expression of myelin basic protein and proteolipid protein during brain development.	Triiodothyronine	33-49	myelin basic protein	Mus musculus	110-130
1712719-2	1991	These results suggest that the regulation of the synthesis of myelin basic protein by hydrocortisone requires the presence of triiodothyronine at a posttranscriptional event, but not for transcription itself.	Triiodothyronine	126-142	myelin basic protein	Mus musculus	62-82
1849506-1	1991	Binding characteristics and effects of 3,5,-3"-triiodo-L-thyronine (T3) on angiotensinogen production in HepG2 were studied in serum-free medium.	Triiodothyronine	68-70	angiotensinogen	Homo sapiens	75-90
1747203-1	1991	The in vivo growth hormone (GH) response of immature domestic fowl to thyrotrophin-releasing hormone (TRH) and GH-releasing factor (GRF) was suppressed in birds fed diets supplemented (1 ppm) with triiodothyronine (T3) or given bolus intraperitoneal (ip) injections (100 micrograms/kg for 10 d) of T3.	Triiodothyronine	197-213	growth hormone	Gallus gallus	12-26
1747203-1	1991	The in vivo growth hormone (GH) response of immature domestic fowl to thyrotrophin-releasing hormone (TRH) and GH-releasing factor (GRF) was suppressed in birds fed diets supplemented (1 ppm) with triiodothyronine (T3) or given bolus intraperitoneal (ip) injections (100 micrograms/kg for 10 d) of T3.	Triiodothyronine	197-213	growth hormone	Gallus gallus	28-30
1747203-1	1991	The in vivo growth hormone (GH) response of immature domestic fowl to thyrotrophin-releasing hormone (TRH) and GH-releasing factor (GRF) was suppressed in birds fed diets supplemented (1 ppm) with triiodothyronine (T3) or given bolus intraperitoneal (ip) injections (100 micrograms/kg for 10 d) of T3.	Triiodothyronine	215-217	growth hormone	Gallus gallus	12-26
1747203-1	1991	The in vivo growth hormone (GH) response of immature domestic fowl to thyrotrophin-releasing hormone (TRH) and GH-releasing factor (GRF) was suppressed in birds fed diets supplemented (1 ppm) with triiodothyronine (T3) or given bolus intraperitoneal (ip) injections (100 micrograms/kg for 10 d) of T3.	Triiodothyronine	215-217	growth hormone	Gallus gallus	28-30
2123790-0	1990	Triiodothyronine increases rat apolipoprotein A-I synthesis and alters high-density lipoprotein composition in vivo.	Triiodothyronine	0-16	apolipoprotein A1	Rattus norvegicus	31-49
2123790-3	1990	12h after a single injection of 3,3",5-triiodothyronine the rate of [14C]leucine incorporation into apoA-I increased 2.1 fold.	Triiodothyronine	32-55	apolipoprotein A1	Rattus norvegicus	100-106
2123790-5	1990	The increase in hepatic apoA-I mRNA levels following 3,3",5-triiodothyronine treatment occurred prior to significant changes in serum triacylglycerol levels.	Triiodothyronine	53-76	apolipoprotein A1	Rattus norvegicus	24-30
2169728-3	1990	Both the wild-type human placental c-erbA beta and Kindred A receptors bound [125I]-triiodothyronine, although the Kindred A receptor had decreased affinity for the hormone.	Triiodothyronine	84-100	thyroid hormone receptor beta	Homo sapiens	35-46
1980023-10	1990	As expected however, plasma TSH and T3 levels were increased at 20 min and 2 h, respectively, following TRH infusions.	Triiodothyronine	36-38	thyrotropin releasing hormone	Rattus norvegicus	104-107
2244867-0	1990	Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes.	Triiodothyronine	12-29	glucokinase	Rattus norvegicus	37-48
2244867-4	1990	Addition of insulin or tri-iodothyronine (T3) to the medium resulted in induction of GK mRNA.	Triiodothyronine	23-40	glucokinase	Rattus norvegicus	85-87
2244867-4	1990	Addition of insulin or tri-iodothyronine (T3) to the medium resulted in induction of GK mRNA.	Triiodothyronine	42-44	glucokinase	Rattus norvegicus	85-87
2124532-4	1990	TRF increased (P less than .01) prolactin (Prl), thyrotropin (TSH), triiodothyronine (T3) and thyroxine (T4) concentrations similarly at the 1.1 and 3.3 micrograms.kg-1 doses and GRF did not interact (P greater than .40) with TRF on the release of these hormones.	Triiodothyronine	68-84	interleukin 5	Bos taurus	0-3
2124532-4	1990	TRF increased (P less than .01) prolactin (Prl), thyrotropin (TSH), triiodothyronine (T3) and thyroxine (T4) concentrations similarly at the 1.1 and 3.3 micrograms.kg-1 doses and GRF did not interact (P greater than .40) with TRF on the release of these hormones.	Triiodothyronine	86-88	interleukin 5	Bos taurus	0-3
2124523-1	1990	In cerebral hemisphere neuronal cultures derived from 15-day-old rat embryos, the addition of L-triiodothyronine (L-T3) or nerve growth factor (NGF) enhanced the expression of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in a dose-dependent manner.	Triiodothyronine	94-112	choline O-acetyltransferase	Rattus norvegicus	176-201
2170411-0	1990	Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture.	Triiodothyronine	0-16	fatty acid synthase	Gallus gallus	49-68
2170411-6	1990	In chick embryo hepatocytes in culture, the stimulatory effect of feeding on fatty acid synthase activity is mimicked by adding triiodothyronine and insulin; the inhibitory effect of starvation is mimicked by adding glucagon or cyclic AMP.	Triiodothyronine	128-144	fatty acid synthase	Gallus gallus	77-96
2170411-7	1990	We now show that triiodothyronine alone stimulates transcription of fatty acid synthase by 4- to 6-fold, about the same as the increase in fatty acid synthase mRNA.	Triiodothyronine	17-33	fatty acid synthase	Gallus gallus	68-87
2170411-9	1990	In combination with triiodothyronine, however, insulin amplifies the response to triiodothyronine by about 2-fold, leading to an overall increase of about 10-fold.	Triiodothyronine	20-36	insulin	Gallus gallus	47-54
2170411-9	1990	In combination with triiodothyronine, however, insulin amplifies the response to triiodothyronine by about 2-fold, leading to an overall increase of about 10-fold.	Triiodothyronine	81-97	insulin	Gallus gallus	47-54
2170411-10	1990	Insulin-like growth factor 1 (IGF-1) has the same effect as insulin, no effect by itself, and amplification of the stimulation by triiodothyronine.	Triiodothyronine	130-146	insulin like growth factor 1	Gallus gallus	0-28
2170411-10	1990	Insulin-like growth factor 1 (IGF-1) has the same effect as insulin, no effect by itself, and amplification of the stimulation by triiodothyronine.	Triiodothyronine	130-146	insulin like growth factor 1	Gallus gallus	30-35
1697751-4	1990	A biphasic response of TSH-beta mRNA was seen following administration of tri-iodothyronine (T3) to hypothyroid rats, with early stimulation followed by later inhibition; these changes were also evident after administration of T3 to androgen-treated animals, although mRNA levels were again suppressed.	Triiodothyronine	74-91	thyroid stimulating hormone subunit beta	Rattus norvegicus	23-31
2289627-2	1990	hTR alpha 1 and beta transfected cells showed increased triiodothyronine (T3) binding capacity, but hTR alpha 2 transfected cells did not.	Triiodothyronine	56-72	thioredoxin reductase 2	Homo sapiens	0-20
2289627-2	1990	hTR alpha 1 and beta transfected cells showed increased triiodothyronine (T3) binding capacity, but hTR alpha 2 transfected cells did not.	Triiodothyronine	74-76	thioredoxin reductase 2	Homo sapiens	0-20
2390738-4	1990	In mice made hyperthyroid by repeated triiodothyronine injections, losses of tissue SDH and proteins caused by food deprivation or surgical denervation were markedly suppressed, while the loss of UCP from the mitochondria remained unchanged.	Triiodothyronine	38-54	aminoadipate-semialdehyde synthase	Mus musculus	84-87
1697751-4	1990	A biphasic response of TSH-beta mRNA was seen following administration of tri-iodothyronine (T3) to hypothyroid rats, with early stimulation followed by later inhibition; these changes were also evident after administration of T3 to androgen-treated animals, although mRNA levels were again suppressed.	Triiodothyronine	93-95	thyroid stimulating hormone subunit beta	Rattus norvegicus	23-31
2162840-1	1990	The alpha-MHC gene is under positive regulation by 3,5,3"-triiodo-L-thyronine (T3), however, the mechanism by which T3 modulates its transcription is not clearly understood.	Triiodothyronine	51-77	myosin heavy chain 6	Homo sapiens	4-13
2120602-0	1990	Triiodothyronine accelerates the synthesis of synapsin I in developing neurons from fetal rat brain cultured in a synthetic medium.	Triiodothyronine	0-16	synapsin I	Rattus norvegicus	46-56
2120602-1	1990	The effect of Triiodothyronine (T3) on Synapsin I appearance in rat cortical neurons has been investigated in vitro.	Triiodothyronine	14-30	synapsin I	Rattus norvegicus	39-49
2120602-1	1990	The effect of Triiodothyronine (T3) on Synapsin I appearance in rat cortical neurons has been investigated in vitro.	Triiodothyronine	32-34	synapsin I	Rattus norvegicus	39-49
2210030-6	1990	Treatment of hypothyroid animals for 1 day with triiodothyronine (T3) reduced expression from both start sites by about 50%; after 4 days of T3 treatment, TSH beta mRNAs derived from both start sites were below detectable levels.	Triiodothyronine	66-68	thyroid stimulating hormone subunit beta	Rattus norvegicus	155-163
2162840-1	1990	The alpha-MHC gene is under positive regulation by 3,5,3"-triiodo-L-thyronine (T3), however, the mechanism by which T3 modulates its transcription is not clearly understood.	Triiodothyronine	79-81	myosin heavy chain 6	Homo sapiens	4-13
2210033-0	1990	Triiodothyronine inhibits transcription from the human growth hormone promoter.	Triiodothyronine	0-16	growth hormone 1	Homo sapiens	55-69
2376285-11	1990	125I accumulation, PBI and iodothyronine (T3, T4) formation in Tg remained significantly higher than in follicles cultured without TSH, showing a transient decrease at days 6 and 9.	Triiodothyronine	42-44	thyroglobulin	Rattus norvegicus	63-65
2116495-0	1990	Tri-iodothyronine inhibition of thyrotrophin-releasing hormone-induced growth hormone release from the chicken adenohypophysis in vitro.	Triiodothyronine	0-17	growth hormone	Gallus gallus	71-85
2328689-0	1990	L-triiodothyronine (T3) regulates cellular growth rate, growth hormone production, and levels of nuclear T3 receptors via distinct dose-response ranges in cultured GC cells.	Triiodothyronine	0-18	gonadotropin releasing hormone receptor	Rattus norvegicus	56-70
2341405-1	1990	The rat hepatic S14 gene is regulated by L-triiodothyronine (T3) and codes for a cytosolic protein (pI 4.9 and Mr 17,010) that is believed to be involved in lipogenesis.	Triiodothyronine	41-59	thyroid hormone responsive	Rattus norvegicus	16-19
2159469-1	1990	Expression of the rat gene designated S14 is rapidly and markedly induced by 3,3",5-triiodo-L-thyronine (T3) in the liver.	Triiodothyronine	77-103	thyroid hormone responsive	Rattus norvegicus	38-41
2159469-1	1990	Expression of the rat gene designated S14 is rapidly and markedly induced by 3,3",5-triiodo-L-thyronine (T3) in the liver.	Triiodothyronine	105-107	thyroid hormone responsive	Rattus norvegicus	38-41
2328689-0	1990	L-triiodothyronine (T3) regulates cellular growth rate, growth hormone production, and levels of nuclear T3 receptors via distinct dose-response ranges in cultured GC cells.	Triiodothyronine	20-22	gonadotropin releasing hormone receptor	Rattus norvegicus	56-70
1696136-0	1990	[Interaction of hormone-receptor complexes of triiodothyronine with DNA and RNA].	Triiodothyronine	46-62	nuclear receptor subfamily 4 group A member 1	Homo sapiens	16-32
2380638-4	1990	The analogous fractions isolated from the livers of hyperthyroid (treated with 3,3",5-triiodo-L-thyronine, T3) animals revealed that newly synthesized apoB-100 accounted for only 46 +/- 10% (G1) and 24 +/- 11% (G2), respectively, of total newly synthesized apoB.	Triiodothyronine	79-105	apolipoprotein B	Rattus norvegicus	151-159
2380638-4	1990	The analogous fractions isolated from the livers of hyperthyroid (treated with 3,3",5-triiodo-L-thyronine, T3) animals revealed that newly synthesized apoB-100 accounted for only 46 +/- 10% (G1) and 24 +/- 11% (G2), respectively, of total newly synthesized apoB.	Triiodothyronine	79-105	apolipoprotein B	Rattus norvegicus	151-155
2179606-1	1990	We studied the expression of angiotensinogen and renin genes in rats treated with 3,3",5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight.	Triiodothyronine	110-112	angiotensinogen	Rattus norvegicus	29-44
2322273-1	1990	The effect of 3,5,3"-triiodo-L-thyronine (T3) on the steady state levels of ferritin heavy chain (ferritin H) mRNA in cultured rat glioma C6 cells and various rat tissues was examined.	Triiodothyronine	14-40	ferritin heavy chain 1	Rattus norvegicus	76-96
2322273-1	1990	The effect of 3,5,3"-triiodo-L-thyronine (T3) on the steady state levels of ferritin heavy chain (ferritin H) mRNA in cultured rat glioma C6 cells and various rat tissues was examined.	Triiodothyronine	14-40	ferritin heavy chain 1	Rattus norvegicus	98-108
2322273-1	1990	The effect of 3,5,3"-triiodo-L-thyronine (T3) on the steady state levels of ferritin heavy chain (ferritin H) mRNA in cultured rat glioma C6 cells and various rat tissues was examined.	Triiodothyronine	42-44	ferritin heavy chain 1	Rattus norvegicus	76-96
2322273-1	1990	The effect of 3,5,3"-triiodo-L-thyronine (T3) on the steady state levels of ferritin heavy chain (ferritin H) mRNA in cultured rat glioma C6 cells and various rat tissues was examined.	Triiodothyronine	42-44	ferritin heavy chain 1	Rattus norvegicus	98-108
2107206-3	1990	After injection of a receptor-saturating dose of triiodothyronine into euthyroid rats, apo A-I gene transcription increased at 20 min, reached a maximum of 179% of control (P less than 0.01) at 3.5 h, and remained elevated for up to 48 h. The abundance of nuclear and total cellular apo A-I mRNA increased at 1 and 2 h, respectively, and exceeded the levels expected from enhanced transcription more than two fold at 24 h after hormone injection.	Triiodothyronine	49-65	apolipoprotein A1	Rattus norvegicus	87-94
2107206-3	1990	After injection of a receptor-saturating dose of triiodothyronine into euthyroid rats, apo A-I gene transcription increased at 20 min, reached a maximum of 179% of control (P less than 0.01) at 3.5 h, and remained elevated for up to 48 h. The abundance of nuclear and total cellular apo A-I mRNA increased at 1 and 2 h, respectively, and exceeded the levels expected from enhanced transcription more than two fold at 24 h after hormone injection.	Triiodothyronine	49-65	apolipoprotein A1	Rattus norvegicus	283-290
2303455-1	1990	Dietary carbohydrate and thyroid hormone (T3) interact to regulate rat liver S14 gene expression.	Triiodothyronine	42-44	thyroid hormone responsive	Rattus norvegicus	77-80
2313216-0	1990	Participation of tri-iodothyronine and metabolic clearance rate in the inhibition of growth hormone secretion in thyroxine-treated domestic fowl.	Triiodothyronine	17-34	growth hormone	Gallus gallus	85-99
2160826-0	1990	Thyroidal inhibition of growth hormone secretion in fowl: tri-iodothyronine-induced down-regulation of thyrotrophin-releasing hormone-binding sites on pituitary membranes.	Triiodothyronine	58-75	growth hormone	Gallus gallus	24-38
2180960-3	1990	Analysis of the binding data indicated that the purified h-TR beta 1 binds to 3,3",5-triiodo-L-thyronine (T3) with a Ka = 2.8 x 10(9) M-1.	Triiodothyronine	106-108	T cell receptor beta locus	Homo sapiens	59-66
2331326-6	1990	A conjoint treatment of END and triiodothyronine (T3) raised the activities of cMDH, mMDH, and LDH in the liver and the skeletal muscle up to the control levels.	Triiodothyronine	32-48	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	85-89
2331326-6	1990	A conjoint treatment of END and triiodothyronine (T3) raised the activities of cMDH, mMDH, and LDH in the liver and the skeletal muscle up to the control levels.	Triiodothyronine	50-52	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	85-89
2154380-14	1990	Forskolin alone did not affect the somatotropin levels but potentiated the growth hormone response to triiodothyronine.	Triiodothyronine	102-118	gonadotropin releasing hormone receptor	Rattus norvegicus	75-89
2307344-3	1990	In all embryonic stages tested, c-GH stimulated the peripheral thyroxine (T4) to triiodothyronine (T3) conversion as demonstrated by the increased plasma T3 level and liver 5"-D activity while the plasma reverse T3 (rT3) level was decreased.	Triiodothyronine	81-97	growth hormone	Gallus gallus	32-36
2307344-3	1990	In all embryonic stages tested, c-GH stimulated the peripheral thyroxine (T4) to triiodothyronine (T3) conversion as demonstrated by the increased plasma T3 level and liver 5"-D activity while the plasma reverse T3 (rT3) level was decreased.	Triiodothyronine	99-101	growth hormone	Gallus gallus	32-36
2329261-0	1990	Acute withdrawal of short-term or prolonged L-triiodothyronine administration to thyroidectomized rats results in similar rapid increases in TSH beta mRNA.	Triiodothyronine	44-62	thyroid stimulating hormone subunit beta	Rattus norvegicus	141-149
2179606-1	1990	We studied the expression of angiotensinogen and renin genes in rats treated with 3,3",5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight.	Triiodothyronine	110-112	renin	Rattus norvegicus	49-54
2303160-2	1990	In Sertoli cells from hypothyroid rats the production of IGF-I was significantly lower than in controls and was greatly stimulated by the administration of triiodothyronine (T3) in vivo.	Triiodothyronine	156-172	insulin-like growth factor 1	Rattus norvegicus	57-62
2303160-2	1990	In Sertoli cells from hypothyroid rats the production of IGF-I was significantly lower than in controls and was greatly stimulated by the administration of triiodothyronine (T3) in vivo.	Triiodothyronine	174-176	insulin-like growth factor 1	Rattus norvegicus	57-62
2167086-0	1990	Selective effect of zinc compared to other divalent metals on L-triiodothyronine binding to rat c-erbA alpha and beta proteins.	Triiodothyronine	62-80	thyroid hormone receptor alpha	Rattus norvegicus	96-108
2171299-5	1990	The regulation of the conversion of thyroxine (T4) to triiodothyronine (T3) by type II 5"-deiodinase in vitro was investigated in brown adipocytes from euthyroid and hypothyroid rats.	Triiodothyronine	54-70	iodothyronine deiodinase 2	Rattus norvegicus	79-100
2171299-5	1990	The regulation of the conversion of thyroxine (T4) to triiodothyronine (T3) by type II 5"-deiodinase in vitro was investigated in brown adipocytes from euthyroid and hypothyroid rats.	Triiodothyronine	72-74	iodothyronine deiodinase 2	Rattus norvegicus	79-100
2136727-0	1990	Stimulation of rat atrial natriuretic peptide (rANP) synthesis by triiodothyronine and thyroxine (T4): T4 as a prohormone in synthesizing rANP.	Triiodothyronine	66-82	natriuretic peptide A	Rattus norvegicus	19-45
2136727-0	1990	Stimulation of rat atrial natriuretic peptide (rANP) synthesis by triiodothyronine and thyroxine (T4): T4 as a prohormone in synthesizing rANP.	Triiodothyronine	66-82	natriuretic peptide A	Rattus norvegicus	47-51
1689711-10	1990	Greater than 50% of the cells in primary collagen cultures contained epidermal growth factor only in the presence of testosterone and triiodothyronine.	Triiodothyronine	134-150	epidermal growth factor	Mus musculus	69-92
34715171-9	2022	Furthermore, sevoflurane decreased the expression of NMDA receptor subunits NR2A and NR2B, as well as PSD-95 in the hippocampus at P15 and those effects of sevoflurane were abolished by T3 administration.	Triiodothyronine	186-188	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	76-80
2296592-1	1990	The rat alpha-myosin heavy-chain (alpha-MHC) gene is regulated by 3,5,3"-triiodo-L-thyronine (T3) in ventricular myocardium and is constitutively expressed in atrial tissue.	Triiodothyronine	66-92	myosin heavy chain 6	Homo sapiens	8-32
2296592-1	1990	The rat alpha-myosin heavy-chain (alpha-MHC) gene is regulated by 3,5,3"-triiodo-L-thyronine (T3) in ventricular myocardium and is constitutively expressed in atrial tissue.	Triiodothyronine	66-92	myosin heavy chain 6	Homo sapiens	34-43
2296592-1	1990	The rat alpha-myosin heavy-chain (alpha-MHC) gene is regulated by 3,5,3"-triiodo-L-thyronine (T3) in ventricular myocardium and is constitutively expressed in atrial tissue.	Triiodothyronine	94-96	myosin heavy chain 6	Homo sapiens	8-32
2296592-1	1990	The rat alpha-myosin heavy-chain (alpha-MHC) gene is regulated by 3,5,3"-triiodo-L-thyronine (T3) in ventricular myocardium and is constitutively expressed in atrial tissue.	Triiodothyronine	94-96	myosin heavy chain 6	Homo sapiens	34-43
33971491-1	2021	OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	121-123	growth hormone 1	Homo sapiens	27-29
33971491-7	2021	RESULTS: GH replacement provoked a decline in serum free T4 concentration (-1.09 +- 1.99 pmol/L; p = 0.02) and an increase in free T3 (+0.34 +- 0.15 pmol/L; p = 0.03); therefore, the free T3:free T4 ratio increased from 0.40 +- 0.02 to 0.47 +- 0.02 (p = 0.002).	Triiodothyronine	131-133	growth hormone 1	Homo sapiens	9-11
33971491-7	2021	RESULTS: GH replacement provoked a decline in serum free T4 concentration (-1.09 +- 1.99 pmol/L; p = 0.02) and an increase in free T3 (+0.34 +- 0.15 pmol/L; p = 0.03); therefore, the free T3:free T4 ratio increased from 0.40 +- 0.02 to 0.47 +- 0.02 (p = 0.002).	Triiodothyronine	188-190	growth hormone 1	Homo sapiens	9-11
34519083-10	2022	In the livers of mice with G347R TRbeta, BZ administration increased reverse T3 content, which corresponded to an increase in Dio3 messenger RNA.	Triiodothyronine	77-79	deiodinase, iodothyronine type III	Mus musculus	126-130
2153160-5	1990	Hyperthyroidism induced by injecting L-triiodothyronine (T3) 15 micrograms/100 gm body weight intraperitoneally for 10 days increased the serum ACE activity in the older rats, but reduced the levels in 2-month-old rats.	Triiodothyronine	37-55	angiotensin I converting enzyme	Rattus norvegicus	144-147
2153160-5	1990	Hyperthyroidism induced by injecting L-triiodothyronine (T3) 15 micrograms/100 gm body weight intraperitoneally for 10 days increased the serum ACE activity in the older rats, but reduced the levels in 2-month-old rats.	Triiodothyronine	57-59	angiotensin I converting enzyme	Rattus norvegicus	144-147
2128417-0	1990	Triiodothyronine administration reduces serum growth hormone levels and growth hormone responses to thyrotropin-releasing hormone in patients with anorexia nervosa.	Triiodothyronine	0-16	growth hormone 1	Homo sapiens	46-60
2128417-0	1990	Triiodothyronine administration reduces serum growth hormone levels and growth hormone responses to thyrotropin-releasing hormone in patients with anorexia nervosa.	Triiodothyronine	0-16	growth hormone 1	Homo sapiens	72-86
2128417-0	1990	Triiodothyronine administration reduces serum growth hormone levels and growth hormone responses to thyrotropin-releasing hormone in patients with anorexia nervosa.	Triiodothyronine	0-16	thyrotropin releasing hormone	Homo sapiens	100-129
33822302-7	2021	Serum triiodothyronine and progesterone concentrations of FTAI+SP4 heifers were similar to those of C heifers but greater (P < 0.05) than those of FTAI heifers.	Triiodothyronine	6-22	Sp4 transcription factor	Homo sapiens	63-66
33971491-1	2021	OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	103-119	growth hormone 1	Homo sapiens	11-25
33971491-1	2021	OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	103-119	growth hormone 1	Homo sapiens	27-29
33971491-1	2021	OBJECTIVE: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	121-123	growth hormone 1	Homo sapiens	11-25
33034050-10	2021	Our data suggest CRYM as a novel antagonist of T3- and androgen-mediated signaling in PCa.	Triiodothyronine	47-49	crystallin mu	Homo sapiens	17-21
34715171-9	2022	Furthermore, sevoflurane decreased the expression of NMDA receptor subunits NR2A and NR2B, as well as PSD-95 in the hippocampus at P15 and those effects of sevoflurane were abolished by T3 administration.	Triiodothyronine	186-188	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	85-89
34715171-9	2022	Furthermore, sevoflurane decreased the expression of NMDA receptor subunits NR2A and NR2B, as well as PSD-95 in the hippocampus at P15 and those effects of sevoflurane were abolished by T3 administration.	Triiodothyronine	186-188	discs large MAGUK scaffold protein 4	Rattus norvegicus	102-108
34715171-10	2022	CONCLUSIONS: A potential therapeutic role of T3 in protecting general anaesthetic induced neuronal injury in the developing brain is likely to occur through enhancing expression of PSD-95 and the NMDA NR2A and NR2B expression.	Triiodothyronine	45-47	discs large MAGUK scaffold protein 4	Rattus norvegicus	181-187
34715171-10	2022	CONCLUSIONS: A potential therapeutic role of T3 in protecting general anaesthetic induced neuronal injury in the developing brain is likely to occur through enhancing expression of PSD-95 and the NMDA NR2A and NR2B expression.	Triiodothyronine	45-47	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	201-205
34715171-10	2022	CONCLUSIONS: A potential therapeutic role of T3 in protecting general anaesthetic induced neuronal injury in the developing brain is likely to occur through enhancing expression of PSD-95 and the NMDA NR2A and NR2B expression.	Triiodothyronine	45-47	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	210-214
34851506-2	2022	The thyroid hormone (triiodothyronine, T3) plays a critical role in metabolic homeostasis via its direct interaction with the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	21-37	thyroid hormone receptor beta	Homo sapiens	126-155
34930399-2	2021	Thyroid hormone receptor alpha-2 (THRalpha-2) acts as an antagonist for triiodothyronine (T3) signaling, and a low expression has been associated with unfavorable tumor characteristics and a higher mortality in breast cancer.	Triiodothyronine	72-88	thyroid hormone receptor alpha	Homo sapiens	34-44
34930399-2	2021	Thyroid hormone receptor alpha-2 (THRalpha-2) acts as an antagonist for triiodothyronine (T3) signaling, and a low expression has been associated with unfavorable tumor characteristics and a higher mortality in breast cancer.	Triiodothyronine	90-92	thyroid hormone receptor alpha	Homo sapiens	34-44
34717926-1	2021	The 3-iodothyronamine (T1AM) and 3-iodothryoacetic acid (TA1), are endogenous occurring compounds structurally related with thyroid hormones (THs, the pro-hormone T4 and the active hormone T3) initially proposed as possible mediators of the rapid effects of T3.	Triiodothyronine	258-260	trace amine associated receptor 1	Homo sapiens	57-60
34436572-1	2021	Type 2 deiodinase (Dio2) amplifies levels of 3,5,3"-L-triiodothyronine (T3), the active form of thyroid hormone, and is essential for cochlear maturation and auditory development.	Triiodothyronine	72-74	deiodinase, iodothyronine, type II	Mus musculus	19-23
34436572-3	2021	Dio2 generates T3 from thyroxine (T4), a more abundant thyroid hormone precursor in the circulation, and is dramatically induced in the cochlea before the onset of hearing.	Triiodothyronine	15-17	deiodinase, iodothyronine, type II	Mus musculus	0-4
34740054-4	2021	In addition, T3 showed hepatoprotective activity, which the noteworthy amelioration in liver aminotransferases (AST and ALT) was evaluated and the histopathological observation exhibited that T3 inhibited lipids accumulation in the hepatic and alleviated liver damage.	Triiodothyronine	13-15	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	112-115
34740054-4	2021	In addition, T3 showed hepatoprotective activity, which the noteworthy amelioration in liver aminotransferases (AST and ALT) was evaluated and the histopathological observation exhibited that T3 inhibited lipids accumulation in the hepatic and alleviated liver damage.	Triiodothyronine	13-15	glutamic pyruvic transaminase, soluble	Mus musculus	120-123
34740054-5	2021	The expression of PPAR-alpha receptor involved lipids metabolism in liver tissue significantly increased after T3 supplementation.	Triiodothyronine	111-113	peroxisome proliferator activated receptor alpha	Mus musculus	18-28
34740054-7	2021	The molecular docking study revealed that T3 has good affinity activity toward to the active site of PPAR-alpha receptor.	Triiodothyronine	42-44	peroxisome proliferator activated receptor alpha	Mus musculus	101-111
34863702-9	2022	100 nM T3 further promoted HSP70 expression and its transfer into the nucleus, which significantly inhibited the expression of vital genes (cyt-c, Caspase-9 and Caspase-3) in mitochondrial pathway (P < 0.05).	Triiodothyronine	7-9	heat shock 70 kDa protein 1B	Bos taurus	27-32
34863702-9	2022	100 nM T3 further promoted HSP70 expression and its transfer into the nucleus, which significantly inhibited the expression of vital genes (cyt-c, Caspase-9 and Caspase-3) in mitochondrial pathway (P < 0.05).	Triiodothyronine	7-9	cytochrome c	Bos taurus	140-145
34863702-9	2022	100 nM T3 further promoted HSP70 expression and its transfer into the nucleus, which significantly inhibited the expression of vital genes (cyt-c, Caspase-9 and Caspase-3) in mitochondrial pathway (P < 0.05).	Triiodothyronine	7-9	caspase 9	Bos taurus	147-156
34863702-9	2022	100 nM T3 further promoted HSP70 expression and its transfer into the nucleus, which significantly inhibited the expression of vital genes (cyt-c, Caspase-9 and Caspase-3) in mitochondrial pathway (P < 0.05).	Triiodothyronine	7-9	caspase 3	Bos taurus	161-170
34851506-2	2022	The thyroid hormone (triiodothyronine, T3) plays a critical role in metabolic homeostasis via its direct interaction with the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	21-37	T cell receptor alpha locus	Homo sapiens	157-163
34851506-2	2022	The thyroid hormone (triiodothyronine, T3) plays a critical role in metabolic homeostasis via its direct interaction with the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	39-41	thyroid hormone receptor beta	Homo sapiens	126-155
34851506-2	2022	The thyroid hormone (triiodothyronine, T3) plays a critical role in metabolic homeostasis via its direct interaction with the thyroid hormone receptor beta (TRbeta).	Triiodothyronine	39-41	T cell receptor alpha locus	Homo sapiens	157-163
34884213-12	2021	Gender-specific reduction in T3 levels could cause the worse cardiac phenotype observed in female mice, while T3 administration improves cardiac function and calcium handling via modified Akt activation.	Triiodothyronine	110-112	thymoma viral proto-oncogene 1	Mus musculus	188-191
34850364-4	2022	METHODS: (125I)T3 uptake and efflux were measured in COS-7 cells transiently transfected with hMCT8 before and after exposure to increasing concentrations of hydrocortisone, dexamethasone, prednisone, prednisolone, amiodarone, desethylamiodarone, dronedarone, buspirone, carbamazepine, valproic acid, and L-carnitine.	Triiodothyronine	15-17	solute carrier family 16 member 2	Homo sapiens	94-99
34850364-7	2022	Amiodarone caused a reduction of T3 uptake by MCT8 only at the highest concentrations used (44% at 50 muM and 68% at 100 muM), and this effect was weaker than that produced by desethylamiodarone and dronedarone; buspirone resulted a potent inhibitor, reducing T3 uptake at 0.1-10 muM.	Triiodothyronine	33-35	solute carrier family 16 member 2	Homo sapiens	46-50
34850364-7	2022	Amiodarone caused a reduction of T3 uptake by MCT8 only at the highest concentrations used (44% at 50 muM and 68% at 100 muM), and this effect was weaker than that produced by desethylamiodarone and dronedarone; buspirone resulted a potent inhibitor, reducing T3 uptake at 0.1-10 muM.	Triiodothyronine	260-262	solute carrier family 16 member 2	Homo sapiens	46-50
34850364-10	2022	CONCLUSION: This study shows a novel effect of some common drugs, which is inhibition of T3 transport mediated by MCT8.	Triiodothyronine	89-91	solute carrier family 16 member 2	Homo sapiens	114-118
34899214-14	2021	Interestingly, (GPC + PCh)/tCr in DLPFC showed a significantly inverse correlation with free tri-iodothyronine (fT3) in hyperthyroid patients at baseline, whereas NAA/tCr showed positive correlations with fT3 and free thyroxine (fT4) in hyperthyroid patients before and after antithyroid treatment, in the posterior parietal cortex.	Triiodothyronine	93-110	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	27-30
34851445-7	2022	Patients with Aristotle score < 10.0 (low risk) receiving T3 had faster extubation than placebo patients (p = 0.021, HR of 1.90, 95% CI: 1.10-3.28) and were significantly less likely to require CPR or experience infection (p = 0.027, OR 8.56, 95% CI:0.99-73.9 and p = 0.022, OR 4.09 95% CI: 1.16-14.4, respectively).	Triiodothyronine	58-60	cytochrome p450 oxidoreductase	Homo sapiens	194-197
34824246-3	2021	In fetal BAT, MO enhances expression of Dio3, which encodes deiodinase 3 (D3) to catabolize triiodothyronine (T3), while a maternally imprinted long noncoding RNA, Dio3 antisense RNA (Dio3os), is inhibited, leading to intracellular T3 deficiency and suppression of BAT development.	Triiodothyronine	92-108	iodothyronine deiodinase 3	Homo sapiens	40-44
34824246-3	2021	In fetal BAT, MO enhances expression of Dio3, which encodes deiodinase 3 (D3) to catabolize triiodothyronine (T3), while a maternally imprinted long noncoding RNA, Dio3 antisense RNA (Dio3os), is inhibited, leading to intracellular T3 deficiency and suppression of BAT development.	Triiodothyronine	110-112	iodothyronine deiodinase 3	Homo sapiens	40-44
34714056-0	2021	Molecular Basis for the Remarkably Different Gas-Phase Behavior of Deprotonated Thyroid Hormones Triiodothyronine (T3) and Reverse Triiodothyronine (rT3): A Clue for Their Discrimination?	Triiodothyronine	131-147	PAXIP1 associated glutamate rich protein 1	Homo sapiens	45-48
34959756-6	2021	Both peripheral treatment protocols induced significant changes in TH concentrations within the hypothalamus, with T3 eliciting a downregulation of hypothalamic AMP-activated protein kinase (AMPK), supporting the existence of a central action of peripheral TH.	Triiodothyronine	115-117	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	161-189
34959756-6	2021	Both peripheral treatment protocols induced significant changes in TH concentrations within the hypothalamus, with T3 eliciting a downregulation of hypothalamic AMP-activated protein kinase (AMPK), supporting the existence of a central action of peripheral TH.	Triiodothyronine	115-117	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	191-195
34714056-3	2021	In this work, the gas-phase behavior of the isomeric thyroid hormones triiodothyronine (T3) and reverse triiodothyronine (rT3) in their deprotonated form was studied at a molecular level using MS-based techniques.	Triiodothyronine	70-86	PAXIP1 associated glutamate rich protein 1	Homo sapiens	18-21
34714056-0	2021	Molecular Basis for the Remarkably Different Gas-Phase Behavior of Deprotonated Thyroid Hormones Triiodothyronine (T3) and Reverse Triiodothyronine (rT3): A Clue for Their Discrimination?	Triiodothyronine	97-113	PAXIP1 associated glutamate rich protein 1	Homo sapiens	45-48
34714056-3	2021	In this work, the gas-phase behavior of the isomeric thyroid hormones triiodothyronine (T3) and reverse triiodothyronine (rT3) in their deprotonated form was studied at a molecular level using MS-based techniques.	Triiodothyronine	88-90	PAXIP1 associated glutamate rich protein 1	Homo sapiens	18-21
34714056-0	2021	Molecular Basis for the Remarkably Different Gas-Phase Behavior of Deprotonated Thyroid Hormones Triiodothyronine (T3) and Reverse Triiodothyronine (rT3): A Clue for Their Discrimination?	Triiodothyronine	115-117	PAXIP1 associated glutamate rich protein 1	Homo sapiens	45-48
34714056-3	2021	In this work, the gas-phase behavior of the isomeric thyroid hormones triiodothyronine (T3) and reverse triiodothyronine (rT3) in their deprotonated form was studied at a molecular level using MS-based techniques.	Triiodothyronine	104-120	PAXIP1 associated glutamate rich protein 1	Homo sapiens	18-21
34750462-0	2021	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure.	Triiodothyronine	4-20	natriuretic peptide B	Homo sapiens	48-74
34750462-7	2021	These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.	Triiodothyronine	32-34	natriuretic peptide B	Homo sapiens	66-69
34175303-12	2021	T3 treatment normalized RyR2 cluster size and number.	Triiodothyronine	0-2	ryanodine receptor 2	Rattus norvegicus	24-28
34463738-0	2021	Mechanisms of OCT4 on 3,5,3"-tri-iodothyronine and FSH-induced granulosa cell development in female mice.	Triiodothyronine	22-46	POU domain, class 5, transcription factor 1	Mus musculus	14-18
34463738-3	2021	Although 3,5,3"-triiodothyronine (T3) enhances the effects of FSH on the regulation of the growth of granulosa cells and development of follicles, it is unclear whether and how TH combines with FSH to regulate OCT4 expression in granulosa cells during the preantral to early antral transition stage.	Triiodothyronine	9-32	follicle stimulating hormone beta	Mus musculus	62-65
34463738-3	2021	Although 3,5,3"-triiodothyronine (T3) enhances the effects of FSH on the regulation of the growth of granulosa cells and development of follicles, it is unclear whether and how TH combines with FSH to regulate OCT4 expression in granulosa cells during the preantral to early antral transition stage.	Triiodothyronine	34-36	follicle stimulating hormone beta	Mus musculus	62-65
34463738-4	2021	Our results showed that T3 enhanced FSH-induced OCT4 expression.	Triiodothyronine	24-26	follicle stimulating hormone beta	Mus musculus	36-39
34463738-4	2021	Our results showed that T3 enhanced FSH-induced OCT4 expression.	Triiodothyronine	24-26	POU domain, class 5, transcription factor 1	Mus musculus	48-52
34463738-13	2021	These findings suggest that OCT4 mediates the T3 and FSH-induced development of follicles.	Triiodothyronine	46-48	POU domain, class 5, transcription factor 1	Mus musculus	28-32
34776993-4	2021	In cultured cerebellar granule cells from mixed-gender neonatal rats, T3 treatment affected transcript levels of the clock genes Per2, Arntl, Nr1d1, and Dbp, suggesting that T3 acts directly on granule cells to control the circadian oscillator.	Triiodothyronine	70-72	period circadian regulator 2	Rattus norvegicus	129-133
34556811-1	2021	The enzyme iodothyronine deiodinase type 3 (DIO3) contributes to cancer proliferation by inactivating the tumor-suppressive actions of thyroid hormone (T3).	Triiodothyronine	152-154	iodothyronine deiodinase 3	Homo sapiens	44-48
34776993-4	2021	In cultured cerebellar granule cells from mixed-gender neonatal rats, T3 treatment affected transcript levels of the clock genes Per2, Arntl, Nr1d1, and Dbp, suggesting that T3 acts directly on granule cells to control the circadian oscillator.	Triiodothyronine	70-72	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	135-140
34776993-4	2021	In cultured cerebellar granule cells from mixed-gender neonatal rats, T3 treatment affected transcript levels of the clock genes Per2, Arntl, Nr1d1, and Dbp, suggesting that T3 acts directly on granule cells to control the circadian oscillator.	Triiodothyronine	70-72	nuclear receptor subfamily 1, group D, member 1	Rattus norvegicus	142-147
34776993-4	2021	In cultured cerebellar granule cells from mixed-gender neonatal rats, T3 treatment affected transcript levels of the clock genes Per2, Arntl, Nr1d1, and Dbp, suggesting that T3 acts directly on granule cells to control the circadian oscillator.	Triiodothyronine	70-72	D-box binding PAR bZIP transcription factor	Rattus norvegicus	153-156
34679181-0	2022	Long-term efficacy of T3 analogue Triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study.	Triiodothyronine	22-24	solute carrier family 16 member 2	Homo sapiens	68-72
34666674-0	2021	The ratio of HDL-C to apoA-I interacts with free triiodothyronine to modulate coronary artery disease risk.	Triiodothyronine	49-65	apolipoprotein A1	Homo sapiens	22-28
34666674-1	2021	OBJECTIVE: In the present work, research was carried out to explore the correlation between the high-density lipoprotein cholesterol (HDL-C)/apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD).	Triiodothyronine	190-206	apolipoprotein A1	Homo sapiens	141-159
34666674-1	2021	OBJECTIVE: In the present work, research was carried out to explore the correlation between the high-density lipoprotein cholesterol (HDL-C)/apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD).	Triiodothyronine	190-206	apolipoprotein A1	Homo sapiens	161-167
34115201-10	2021	RESULTS: The dentifrices placebo and NaF in the low flow presented lower SMH and higher Ra in T3 and lower Ca% compared to the same dentifrices in normal flow.	Triiodothyronine	94-96	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
34660805-1	2021	Background: Type 2 deiodinase (Dio2) is a selenoenzyme that is mainly expressed in the endoplasmic reticulum of the central nervous system, brown adipose tissue, and placenta and is responsible for outer ring deiodination of thyroxine (T4) to form biologically active triiodothyronine (T3).	Triiodothyronine	268-284	iodothyronine deiodinase 2	Homo sapiens	31-35
34660805-1	2021	Background: Type 2 deiodinase (Dio2) is a selenoenzyme that is mainly expressed in the endoplasmic reticulum of the central nervous system, brown adipose tissue, and placenta and is responsible for outer ring deiodination of thyroxine (T4) to form biologically active triiodothyronine (T3).	Triiodothyronine	286-288	iodothyronine deiodinase 2	Homo sapiens	31-35
34330038-7	2021	Our simulated molecular docking analysis showed that OTC combined with the sodium iodide cotransporter protein may result in excessive T3 synthesis.	Triiodothyronine	135-137	solute carrier family 5 member 5	Danio rerio	75-102
34675885-3	2021	Our aim was to elucidate the role of SMTNL1 in SKM under physiological and pathological 3,3",5-Triiodo-L-thyronine (T3) concentrations.	Triiodothyronine	116-118	smoothelin-like 1	Mus musculus	37-43
34675885-14	2021	T3 overload strongly increased the rate of acidification and a shift to glycolysis, while SMTNL1 overexpression antagonizes the T3 effects.	Triiodothyronine	128-130	smoothelin-like 1	Mus musculus	90-96
34370696-9	2021	Increased renal DIO1 activity may contribute to higher T3 concentrations and prolonged thyrotoxicosis followed by hypothyroidism in an aged mouse organism.	Triiodothyronine	55-57	deiodinase, iodothyronine, type I	Mus musculus	16-20
34638630-9	2021	T3 treatment combined with SMTNL1 overexpression impeded the activity of MP.	Triiodothyronine	0-2	smoothelin-like 1	Mus musculus	27-33
34114484-8	2021	RESULTS: The radial glia, mainly the outer radial glia, and astrocytes coexpress SLCO1C1 and DIO2, indicating close cooperation between the T4 transporter OATP1C1 and DIO2 in local T3 formation.	Triiodothyronine	181-183	solute carrier organic anion transporter family member 1C1	Homo sapiens	81-88
34114484-8	2021	RESULTS: The radial glia, mainly the outer radial glia, and astrocytes coexpress SLCO1C1 and DIO2, indicating close cooperation between the T4 transporter OATP1C1 and DIO2 in local T3 formation.	Triiodothyronine	181-183	iodothyronine deiodinase 2	Homo sapiens	93-97
34114484-8	2021	RESULTS: The radial glia, mainly the outer radial glia, and astrocytes coexpress SLCO1C1 and DIO2, indicating close cooperation between the T4 transporter OATP1C1 and DIO2 in local T3 formation.	Triiodothyronine	181-183	solute carrier organic anion transporter family member 1C1	Homo sapiens	155-162
34114484-8	2021	RESULTS: The radial glia, mainly the outer radial glia, and astrocytes coexpress SLCO1C1 and DIO2, indicating close cooperation between the T4 transporter OATP1C1 and DIO2 in local T3 formation.	Triiodothyronine	181-183	iodothyronine deiodinase 2	Homo sapiens	167-171
34473081-6	2021	In GD patients, serum ADA levels were positively associated with serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid-stimulating hormone receptor antibody (TRAb) levels and total thyroid gland volume (thyroid VolT), and negatively associated with serum thyroid-stimulating hormone receptor (TSH) levels (all p < 0.05).	Triiodothyronine	76-92	adenosine deaminase	Homo sapiens	22-25
34502288-5	2021	Thyroid-specific Zfp36l2-/- females were hypothyroid, with reduced levels of circulating free Thyroxine (cfT4) and Triiodothyronine (cfT3).	Triiodothyronine	115-131	ZFP36 ring finger protein like 2	Homo sapiens	17-24
34218922-18	2021	The number of mucin-2 cells in the ileum increased more than 2-fold in calves fed T3.	Triiodothyronine	82-84	mucin-2	Bos taurus	14-21
34269617-6	2021	Serum T4 and hypophyseal Tshb or Dio2 expression were also not affected in any group, only TRalpha1 mutant males exhibited a reduction in serum T3 levels after the treatment.	Triiodothyronine	144-146	detected by T cells 1	Mus musculus	91-99
34434048-5	2021	Results: Compared with the normal serum T3 level group, patients with low serum T3 levels had higher systolic blood pressure and a higher proportion of heart disease, and lower levels of total T4, free T4, hemoglobin, serum albumin, blood calcium, serum total bilirubin, alanine aminotransferase, and 24-h urine volume (all P < 0.05).	Triiodothyronine	80-82	albumin	Homo sapiens	224-231
34434048-5	2021	Results: Compared with the normal serum T3 level group, patients with low serum T3 levels had higher systolic blood pressure and a higher proportion of heart disease, and lower levels of total T4, free T4, hemoglobin, serum albumin, blood calcium, serum total bilirubin, alanine aminotransferase, and 24-h urine volume (all P < 0.05).	Triiodothyronine	80-82	glutamic--pyruvic transaminase	Homo sapiens	271-295
34137729-3	2021	Metformin is used to decrease insulin resistance, and at present it is assumed to influence the effect of triiodothyronine, as well.	Triiodothyronine	106-122	insulin	Homo sapiens	30-37
34445344-3	2021	Acute T3 treatment significantly enhanced basal, maximal, ATP-linked, and proton-leak oxygen consumption rates (OCRs) of primary differentiated mouse brown adipocytes accompanied with increased protein abundances of uncoupling protein 1 (UCP1) and mitochondrial Ca2+ uniporter (MCU).	Triiodothyronine	6-8	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	216-236
34445344-3	2021	Acute T3 treatment significantly enhanced basal, maximal, ATP-linked, and proton-leak oxygen consumption rates (OCRs) of primary differentiated mouse brown adipocytes accompanied with increased protein abundances of uncoupling protein 1 (UCP1) and mitochondrial Ca2+ uniporter (MCU).	Triiodothyronine	6-8	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	238-242
34445344-11	2021	We suggest that short-term exposure of T3 induces UCP1 upregulation and mitochondrial activation due to PLC-mediated (Ca2+)i elevation in brown adipocytes.	Triiodothyronine	39-41	uncoupling protein 1	Homo sapiens	50-54
34160415-10	2021	Persistent T3 hyperthyroidism, most likely caused by TSH-R-stimulated T3 production in large metastasis in the 8th right rib, was eliminated by rib resection.	Triiodothyronine	70-72	thyroid stimulating hormone receptor	Homo sapiens	53-58
34209648-10	2021	Simultaneously, pituitary level of growth hormone-releasing hormone and serum concentrations of growth hormone and corticosterone were reduced, while that of triiodothyronine was enhanced.	Triiodothyronine	158-174	growth hormone releasing hormone	Rattus norvegicus	35-67
34853265-7	2021	The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration.	Triiodothyronine	241-243	glial fibrillary acidic protein	Mus musculus	33-64
33606002-7	2021	Data from fish, amphibians and birds were key in shifting our view on the relative importance of activating and inactivating deiodination pathways, and in showing the impact of D2 and D3 not only in local but also whole body T3 availability.	Triiodothyronine	225-227	iodothyronine deiodinase 2	Homo sapiens	177-186
34069457-4	2021	Most published disease-associated THRA variants are located in the LBD of THRA1 and impede triiodothyronine (T3) binding.	Triiodothyronine	91-107	thyroid hormone receptor alpha	Homo sapiens	34-38
34069457-4	2021	Most published disease-associated THRA variants are located in the LBD of THRA1 and impede triiodothyronine (T3) binding.	Triiodothyronine	109-111	thyroid hormone receptor alpha	Homo sapiens	34-38
34069457-4	2021	Most published disease-associated THRA variants are located in the LBD of THRA1 and impede triiodothyronine (T3) binding.	Triiodothyronine	109-111	nuclear receptor subfamily 1 group D member 1	Homo sapiens	74-79
34925565-13	2021	Acute cholinesterase inhibition may induce high levels of cortisol, free triiodothyronine, thyroxine and thyroid-stimulating hormone.	Triiodothyronine	73-89	butyrylcholinesterase	Rattus norvegicus	6-20
34853265-7	2021	The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration.	Triiodothyronine	241-243	glial fibrillary acidic protein	Mus musculus	66-70
35524426-0	2022	A U-shaped association between serum albumin with total triiodothyronine in adults.	Triiodothyronine	56-72	albumin	Homo sapiens	37-44
34936295-12	2021	T3 affected apoptosis and cell cycle of glioma cells through regulating THRA and THRB expressions.	Triiodothyronine	0-2	thyroid hormone receptor alpha	Homo sapiens	72-76
34936295-12	2021	T3 affected apoptosis and cell cycle of glioma cells through regulating THRA and THRB expressions.	Triiodothyronine	0-2	thyroid hormone receptor beta	Homo sapiens	81-85
35524426-3	2022	The purpose of this study was to investigate the relationship between serum ALB levels and total triiodothyronine (TT3) in adults.	Triiodothyronine	97-113	albumin	Homo sapiens	76-79
35614155-3	2022	Specifically, in adult murine cardiomyocytes, metoprolol, a cardioselective beta1-adrenergic receptor blocker, when given with triiodothyronine (T3, a thyroid hormone) accentuates the ability of T3 to stimulate ERK1/2 phosphorylation and proliferative signaling by inhibiting expression of the nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.	Triiodothyronine	127-143	adrenergic receptor, beta 1	Mus musculus	76-101
35427919-0	2022	Peripheral lower triiodothyronine levels related to interleukin-6 in patients with first-episode schizophrenia.	Triiodothyronine	17-33	interleukin 6	Homo sapiens	52-65
35614155-3	2022	Specifically, in adult murine cardiomyocytes, metoprolol, a cardioselective beta1-adrenergic receptor blocker, when given with triiodothyronine (T3, a thyroid hormone) accentuates the ability of T3 to stimulate ERK1/2 phosphorylation and proliferative signaling by inhibiting expression of the nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.	Triiodothyronine	145-147	adrenergic receptor, beta 1	Mus musculus	76-101
35614155-3	2022	Specifically, in adult murine cardiomyocytes, metoprolol, a cardioselective beta1-adrenergic receptor blocker, when given with triiodothyronine (T3, a thyroid hormone) accentuates the ability of T3 to stimulate ERK1/2 phosphorylation and proliferative signaling by inhibiting expression of the nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.	Triiodothyronine	145-147	mitogen-activated protein kinase 3	Mus musculus	211-217
35614155-3	2022	Specifically, in adult murine cardiomyocytes, metoprolol, a cardioselective beta1-adrenergic receptor blocker, when given with triiodothyronine (T3, a thyroid hormone) accentuates the ability of T3 to stimulate ERK1/2 phosphorylation and proliferative signaling by inhibiting expression of the nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.	Triiodothyronine	145-147	mitogen-activated protein kinase 3	Mus musculus	310-316
35614155-3	2022	Specifically, in adult murine cardiomyocytes, metoprolol, a cardioselective beta1-adrenergic receptor blocker, when given with triiodothyronine (T3, a thyroid hormone) accentuates the ability of T3 to stimulate ERK1/2 phosphorylation and proliferative signaling by inhibiting expression of the nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.	Triiodothyronine	145-147	dual specificity phosphatase 5	Mus musculus	339-369
35172007-6	2022	We measured klf9 mRNA following exposures to triiodothyronine (T3), corticosterone (CORT), and TCDD in the Xenopus laevis cell line XLK-WG.	Triiodothyronine	45-61	Kruppel-like factor 9 L homeolog	Xenopus laevis	12-16
35452598-3	2022	The addition of thyroid hormone T3 increased the binding of THRB to the CYP3A4 proximal enhancer, restored the super-enhancer status and gene expression of NFIC, and reduced the expression of AFP.	Triiodothyronine	32-34	thyroid hormone receptor beta	Homo sapiens	60-64
35452598-3	2022	The addition of thyroid hormone T3 increased the binding of THRB to the CYP3A4 proximal enhancer, restored the super-enhancer status and gene expression of NFIC, and reduced the expression of AFP.	Triiodothyronine	32-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78
35452598-3	2022	The addition of thyroid hormone T3 increased the binding of THRB to the CYP3A4 proximal enhancer, restored the super-enhancer status and gene expression of NFIC, and reduced the expression of AFP.	Triiodothyronine	32-34	nuclear factor I C	Homo sapiens	156-160
35452598-3	2022	The addition of thyroid hormone T3 increased the binding of THRB to the CYP3A4 proximal enhancer, restored the super-enhancer status and gene expression of NFIC, and reduced the expression of AFP.	Triiodothyronine	32-34	alpha fetoprotein	Homo sapiens	192-195
35572853-9	2022	Both low-density lipoprotein (LDL) and total cholesterol levels were reduced, while sex hormone-binding globulin (SHBG) increased after LT3 treatment compared with LT4 treatment.	Triiodothyronine	136-139	sex hormone binding globulin	Homo sapiens	84-112
35572853-9	2022	Both low-density lipoprotein (LDL) and total cholesterol levels were reduced, while sex hormone-binding globulin (SHBG) increased after LT3 treatment compared with LT4 treatment.	Triiodothyronine	136-139	sex hormone binding globulin	Homo sapiens	114-118
35357974-8	2022	Furthermore, we identified MCT10 as an alternative TH transporter in iBMECs that contributes to T3 uptake, the biological active thyroid hormone.	Triiodothyronine	96-98	solute carrier family 16 member 10	Homo sapiens	27-32
35172007-6	2022	We measured klf9 mRNA following exposures to triiodothyronine (T3), corticosterone (CORT), and TCDD in the Xenopus laevis cell line XLK-WG.	Triiodothyronine	63-65	Kruppel-like factor 9 L homeolog	Xenopus laevis	12-16
35172007-7	2022	klf9 was induced 6-fold by 50 nM T3, 4-fold by 100 nM CORT, and 3-fold by 175 nM TCDD.	Triiodothyronine	33-35	Kruppel-like factor 9 L homeolog	Xenopus laevis	0-4
35172007-8	2022	Co-treatments of CORT and TCDD or T3 and TCDD induced klf9 7- and 11-fold, respectively, while treatment with all 3 agents induced a 15-fold increase.	Triiodothyronine	34-36	Kruppel-like factor 9 L homeolog	Xenopus laevis	54-58
35439023-6	2022	In support of this conclusion, inhibiting the synthesis of triiodothyronine (T3) with propylthiouracil rescued pressure overload-induced hypertrophy and improved myocardial contractility and systolic function in PTP1B cKO mice.	Triiodothyronine	59-75	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	212-217
35629879-1	2022	BACKGROUND: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3).	Triiodothyronine	85-101	iodothyronine deiodinase 2	Homo sapiens	31-35
35629879-1	2022	BACKGROUND: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3).	Triiodothyronine	103-105	iodothyronine deiodinase 2	Homo sapiens	31-35
35439023-6	2022	In support of this conclusion, inhibiting the synthesis of triiodothyronine (T3) with propylthiouracil rescued pressure overload-induced hypertrophy and improved myocardial contractility and systolic function in PTP1B cKO mice.	Triiodothyronine	77-79	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	212-217
35313973-12	2022	Under BMP4 induction, T3 significantly enhances trophoblast differentiation.	Triiodothyronine	22-24	bone morphogenetic protein 4	Homo sapiens	6-10
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Triiodothyronine	106-122	proteasome subunit alpha 2	Gallus gallus	33-38
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Triiodothyronine	106-122	thiamin pyrophosphokinase 1	Gallus gallus	40-44
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Triiodothyronine	106-122	metal regulatory transcription factor 1	Gallus gallus	46-50
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Triiodothyronine	106-122	cullin 1	Gallus gallus	56-60
35409180-8	2022	In a series of five OPCs, conjugates bearing T3-Ser-Phe-Asn (SFN) or T3-Tyr-Trp-Asn (YWN) side chains exhibited considerably improved anticoagulant characteristics.	Triiodothyronine	45-47	RNA exonuclease 2	Homo sapiens	61-64
35038735-1	2022	CONTEXT: 3,5,3"-L-triiodothyronine (T3) is a potent inducer of hepatocyte proliferation via the Wnt/beta-catenin signaling pathway.	Triiodothyronine	36-38	catenin (cadherin associated protein), beta 1	Mus musculus	100-112
35384117-4	2022	Tanycytes respond to TSH through increased expression of thyroid hormone (TH) deiodinase 2 (Dio2), which leads to heightened production of intrahypothalamic triiodothyronine (T3) during longer days of spring and summer.	Triiodothyronine	157-173	iodothyronine deiodinase 2	Homo sapiens	92-96
35384117-4	2022	Tanycytes respond to TSH through increased expression of thyroid hormone (TH) deiodinase 2 (Dio2), which leads to heightened production of intrahypothalamic triiodothyronine (T3) during longer days of spring and summer.	Triiodothyronine	175-177	iodothyronine deiodinase 2	Homo sapiens	92-96
35384117-6	2022	The mechanism(s) through which T3 impinges upon GnRH remain(s) unclear.	Triiodothyronine	31-33	gonadotropin releasing hormone 1	Homo sapiens	48-52
35327410-3	2022	In resting monocytes, 5 microM T3 affected the expression of a small number of monocyte-to-macrophage differentiation-associated genes, including TLR4 (p-value < 0.05, expression fold change >1.5).	Triiodothyronine	31-33	toll like receptor 4	Homo sapiens	146-150
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	frizzled class receptor 8	Mus musculus	91-95
35038735-3	2022	However, the mechanism by which T3 increases Wnt/beta-catenin signaling in hepatocytes has not yet been determined.	Triiodothyronine	32-34	catenin (cadherin associated protein), beta 1	Mus musculus	49-61
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	frizzled class receptor 8	Mus musculus	97-116
35038735-5	2022	METHODS: Wild type (WT) mice, TRbeta knockout mice (TRbeta KO), TRbeta mutant mice with either specifically abrogated DNA-binding (TRbeta GS) or abrogated direct PI3K activation (TRbeta 147F) were treated with T3 for 6h or 7 days.	Triiodothyronine	210-212	thyroid hormone receptor beta	Mus musculus	64-70
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	catenin (cadherin associated protein), beta 1	Mus musculus	122-128
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	catenin (cadherin associated protein), beta 1	Mus musculus	130-142
35038735-9	2022	RESULTS: T3 induced hepatocyte proliferation with an increased number of Ki67-positive cells in WT and TRbeta 147F mice (9.2+-6.5% and 10.1+-2.9%) compared to TRbeta KO and TRbeta GS mice (1.2+-1.1% and 1.5+-0.9%).	Triiodothyronine	9-11	antigen identified by monoclonal antibody Ki 67	Mus musculus	73-77
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	thyroid hormone receptor beta	Mus musculus	196-202
35038735-9	2022	RESULTS: T3 induced hepatocyte proliferation with an increased number of Ki67-positive cells in WT and TRbeta 147F mice (9.2+-6.5% and 10.1+-2.9%) compared to TRbeta KO and TRbeta GS mice (1.2+-1.1% and 1.5+-0.9%).	Triiodothyronine	9-11	thyroid hormone receptor beta	Mus musculus	103-109
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	catenin (cadherin associated protein), beta 1	Mus musculus	58-70
35038735-10	2022	Microarray analysis and GSEA showed that genes of the Wnt/beta-catenin pathway, among them Fzd8 (Frizzled receptor 8) and Ctnnb1 (beta-catenin), were positively enriched only in T3-treated WT and TRbeta 147F mice while anti-proliferative factor Btg2 was repressed.	Triiodothyronine	178-180	BTG anti-proliferation factor 2	Mus musculus	245-249
35280892-2	2022	Temperature Regulation and Metabolism: Triggered by falling skin temperature, Thyrotropin-Releasing Hormone (TRH) from hypothalamus induces release of Thyroid-Stimulating Hormone (TSH) and Prolactin from pituitary gland anterior lobe that stimulate thyroid generation of triiodothyronine and thyroxine (T4).	Triiodothyronine	271-287	thyrotropin releasing hormone	Homo sapiens	78-107
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	32-34	uncoupling protein 2	Homo sapiens	135-139
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	32-34	protein arginine methyltransferase 1	Homo sapiens	145-150
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	231-233	mitochondrial calcium uniporter	Homo sapiens	99-127
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	231-233	mitochondrial calcium uniporter	Homo sapiens	129-132
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	231-233	uncoupling protein 2	Homo sapiens	135-139
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	231-233	protein arginine methyltransferase 1	Homo sapiens	145-150
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	32-34	mitochondrial calcium uniporter	Homo sapiens	99-127
35091061-7	2022	Live-cell imaging revealed that T3-induced enhancement of mitochondrial Ca2+ uptake depends on the mitochondrial Ca2+ uniporter (MCU), UCP2, and PRMT1 that are essential for increased mitochondrial ATP ((ATP)mito) production after T3 treatment.	Triiodothyronine	32-34	mitochondrial calcium uniporter	Homo sapiens	129-132
35400820-1	2022	Tocotrienol (T3), a vitamin E (Vit E) isoform, is known to have both biological and antioxidant effects.	Triiodothyronine	13-15	vitrin	Mus musculus	31-34
35280892-2	2022	Temperature Regulation and Metabolism: Triggered by falling skin temperature, Thyrotropin-Releasing Hormone (TRH) from hypothalamus induces release of Thyroid-Stimulating Hormone (TSH) and Prolactin from pituitary gland anterior lobe that stimulate thyroid generation of triiodothyronine and thyroxine (T4).	Triiodothyronine	271-287	thyrotropin releasing hormone	Homo sapiens	109-112
35172387-5	2022	No changes were observed in the expression of genes after PFBA and TDCPP exposure; however, T3 exposure upregulated tralpha and trbeta expression in both fish species.	Triiodothyronine	92-94	thyroid hormone receptor alpha a	Danio rerio	116-123
35172387-5	2022	No changes were observed in the expression of genes after PFBA and TDCPP exposure; however, T3 exposure upregulated tralpha and trbeta expression in both fish species.	Triiodothyronine	92-94	thyroid hormone receptor alpha a	Danio rerio	128-134
35132135-6	2022	More importantly, treatment of tadpoles with cell cycle inhibitors blocked T3-induced intestinal remodeling, especially larval epithelial cell death, suggesting that TRalpha-dependent activation of cell cycle is important for T3-induced apoptosis during intestinal remodeling.	Triiodothyronine	75-77	T cell receptor alpha locus	Xenopus tropicalis	166-173
35132135-6	2022	More importantly, treatment of tadpoles with cell cycle inhibitors blocked T3-induced intestinal remodeling, especially larval epithelial cell death, suggesting that TRalpha-dependent activation of cell cycle is important for T3-induced apoptosis during intestinal remodeling.	Triiodothyronine	226-228	T cell receptor alpha locus	Xenopus tropicalis	166-173
35065349-6	2022	The T3 analogues and TRF displayed neuroprotective effects (P < .05) via restoration of cell viability and activation of antioxidant enzymes (e.g., superoxide dismutase, catalase).	Triiodothyronine	4-6	catalase	Homo sapiens	170-178
35224111-10	2022	Intrathyroidal CD4+CXCR5+ICOShigh Tfh cells were positively correlated with free triiodothyronine (FT3) in HT patients but negatively correlated with FT3 in GD patients.	Triiodothyronine	81-97	CD4 molecule	Homo sapiens	15-18
35224111-10	2022	Intrathyroidal CD4+CXCR5+ICOShigh Tfh cells were positively correlated with free triiodothyronine (FT3) in HT patients but negatively correlated with FT3 in GD patients.	Triiodothyronine	81-97	C-X-C motif chemokine receptor 5	Homo sapiens	19-24
35163026-3	2022	Thyroid hormone is an important signaling molecule to maintain normal metabolism, and in vivo and vitro studies have shown that regulation of the 3,5,3"-triiodothyronine (T3)/ thyroid hormone receptor (TR) axis is beneficial not only for metabolic symptoms but also for the improvement of NAFLD and even for the repair of liver injury.	Triiodothyronine	146-169	coagulation factor II thrombin receptor	Homo sapiens	176-200
35162474-11	2022	Insulin was claimed during 3.5% of pregnancies, most frequently in T3 (3.3%).	Triiodothyronine	67-69	insulin	Homo sapiens	0-7
35164063-5	2022	We determined 1 nM as the induction concentration of T3 and thibz expression as the sensitive endpoint for detecting TH signaling disruptors given its highest response to T3, BPA, and TBBPA.	Triiodothyronine	171-173	thyroid hormone induced bZip protein S homeolog	Xenopus laevis	60-65
35163026-3	2022	Thyroid hormone is an important signaling molecule to maintain normal metabolism, and in vivo and vitro studies have shown that regulation of the 3,5,3"-triiodothyronine (T3)/ thyroid hormone receptor (TR) axis is beneficial not only for metabolic symptoms but also for the improvement of NAFLD and even for the repair of liver injury.	Triiodothyronine	146-169	coagulation factor II thrombin receptor	Homo sapiens	202-204
35163026-3	2022	Thyroid hormone is an important signaling molecule to maintain normal metabolism, and in vivo and vitro studies have shown that regulation of the 3,5,3"-triiodothyronine (T3)/ thyroid hormone receptor (TR) axis is beneficial not only for metabolic symptoms but also for the improvement of NAFLD and even for the repair of liver injury.	Triiodothyronine	171-173	coagulation factor II thrombin receptor	Homo sapiens	176-200
35163026-3	2022	Thyroid hormone is an important signaling molecule to maintain normal metabolism, and in vivo and vitro studies have shown that regulation of the 3,5,3"-triiodothyronine (T3)/ thyroid hormone receptor (TR) axis is beneficial not only for metabolic symptoms but also for the improvement of NAFLD and even for the repair of liver injury.	Triiodothyronine	171-173	coagulation factor II thrombin receptor	Homo sapiens	202-204
2555217-1	1989	The activity of liver 6-phosphofructo-2-kinase (PFK-2), the enzyme that catalyses the synthesis of fructose 2,6-bisphosphate, was markedly decreased in hypothyroid rats and partially restored after 3 days of treatment with triiodothyronine.	Triiodothyronine	223-239	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	48-53
2584194-2	1989	In rat liver, triiodothyronine (T3) and dietary carbohydrate induce the expression of the genes coding for malic enzyme (ME) (EC 1.1.1.40) and S14 protein.	Triiodothyronine	14-30	thyroid hormone responsive	Rattus norvegicus	143-146
2584194-2	1989	In rat liver, triiodothyronine (T3) and dietary carbohydrate induce the expression of the genes coding for malic enzyme (ME) (EC 1.1.1.40) and S14 protein.	Triiodothyronine	32-34	thyroid hormone responsive	Rattus norvegicus	143-146
2574126-1	1989	Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) elevated plasma thyroxine (T4) and triiodothyronine (T3) concentrations in a (euthyroid) control line of chickens and in an autosomal dwarf strain.	Triiodothyronine	93-109	thyrotropin releasing hormone	Gallus gallus	0-29
2791994-0	1989	Pituitary insulin-like growth factor-I gene expression: regulation by triiodothyronine and growth hormone.	Triiodothyronine	70-86	insulin-like growth factor 1	Rattus norvegicus	10-38
2574126-1	1989	Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) elevated plasma thyroxine (T4) and triiodothyronine (T3) concentrations in a (euthyroid) control line of chickens and in an autosomal dwarf strain.	Triiodothyronine	93-109	thyrotropin releasing hormone	Gallus gallus	31-34
2574126-1	1989	Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) elevated plasma thyroxine (T4) and triiodothyronine (T3) concentrations in a (euthyroid) control line of chickens and in an autosomal dwarf strain.	Triiodothyronine	111-113	thyrotropin releasing hormone	Gallus gallus	0-29
2574126-1	1989	Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) elevated plasma thyroxine (T4) and triiodothyronine (T3) concentrations in a (euthyroid) control line of chickens and in an autosomal dwarf strain.	Triiodothyronine	111-113	thyrotropin releasing hormone	Gallus gallus	31-34
2613750-0	1989	Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid.	Triiodothyronine	145-161	tumor necrosis factor	Homo sapiens	14-46
2687221-5	1989	Triiodothyronine (T3) supplementation (2 to 10 nM) increased (P less than .05) GPDH specific activity and increased lipid droplet size in preadipocytes compared with control cultures (no T3 but with insulin and transferrin).	Triiodothyronine	0-16	insulin	Sus scrofa	199-206
2613750-0	1989	Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid.	Triiodothyronine	145-161	epidermal growth factor receptor	Homo sapiens	71-103
2687221-5	1989	Triiodothyronine (T3) supplementation (2 to 10 nM) increased (P less than .05) GPDH specific activity and increased lipid droplet size in preadipocytes compared with control cultures (no T3 but with insulin and transferrin).	Triiodothyronine	0-16	transferrin	Sus scrofa	211-222
2687221-5	1989	Triiodothyronine (T3) supplementation (2 to 10 nM) increased (P less than .05) GPDH specific activity and increased lipid droplet size in preadipocytes compared with control cultures (no T3 but with insulin and transferrin).	Triiodothyronine	18-20	insulin	Sus scrofa	199-206
2681273-2	1989	In the presence of 0.2 nM triiodothyronine and 0.5 microM insulin, up to 25% of the cells were able to undergo terminal adipose differentiation within 18 d, as assessed by lipid accumulation and the expression of lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (GPDH) activities.	Triiodothyronine	26-42	lipoprotein lipase	Homo sapiens	213-231
2681273-2	1989	In the presence of 0.2 nM triiodothyronine and 0.5 microM insulin, up to 25% of the cells were able to undergo terminal adipose differentiation within 18 d, as assessed by lipid accumulation and the expression of lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (GPDH) activities.	Triiodothyronine	26-42	lipoprotein lipase	Homo sapiens	233-236
2687221-5	1989	Triiodothyronine (T3) supplementation (2 to 10 nM) increased (P less than .05) GPDH specific activity and increased lipid droplet size in preadipocytes compared with control cultures (no T3 but with insulin and transferrin).	Triiodothyronine	18-20	transferrin	Sus scrofa	211-222
2613750-5	1989	We also found that triiodothyronine at physiological concentrations exerts synergistic control on the action of TGF alpha alone, or in association with TGF beta 1, on EGF receptor mRNA expression.	Triiodothyronine	19-35	transforming growth factor alpha	Homo sapiens	112-121
2613750-5	1989	We also found that triiodothyronine at physiological concentrations exerts synergistic control on the action of TGF alpha alone, or in association with TGF beta 1, on EGF receptor mRNA expression.	Triiodothyronine	19-35	transforming growth factor beta 1	Homo sapiens	152-162
2613750-5	1989	We also found that triiodothyronine at physiological concentrations exerts synergistic control on the action of TGF alpha alone, or in association with TGF beta 1, on EGF receptor mRNA expression.	Triiodothyronine	19-35	epidermal growth factor receptor	Homo sapiens	167-179
2768233-3	1989	Sequences in the first exon between +9 and +37 base pairs (bp) enhanced gene expression from the human TSH beta promoter in the absence of thyroid hormone as well as mediated a concentration-dependent triiodothyronine (L-T3) decrease in gene expression.	Triiodothyronine	201-217	thyroid stimulating hormone subunit beta	Homo sapiens	103-111
2514397-0	1989	Exogenous triiodothyronine lowers thyrotropin-releasing hormone concentrations in the specific hypothalamic nucleus (paraventricular) involved in thyrotropin regulation and also in posterior nucleus.	Triiodothyronine	10-26	thyrotropin releasing hormone	Rattus norvegicus	34-63
2768233-3	1989	Sequences in the first exon between +9 and +37 base pairs (bp) enhanced gene expression from the human TSH beta promoter in the absence of thyroid hormone as well as mediated a concentration-dependent triiodothyronine (L-T3) decrease in gene expression.	Triiodothyronine	219-223	thyroid stimulating hormone subunit beta	Homo sapiens	103-111
2474323-1	1989	The action of triiodothyronine on the production of alpha-fetoprotein and albumin in serum-free cultures of Hep G2 human hepatoma cells was examined.	Triiodothyronine	14-30	alpha fetoprotein	Homo sapiens	52-69
2509616-10	1989	The 1 mg dose of GRF increased (P less than 0.05) blood concentrations of SM-C (on days 10 and 19) and glucose (on day 19), but did not affect blood concentrations of prolactin, insulin, cortisol, tri-iodothyronine (T3), thyroxine (T4), non-esterified fatty acids (NEFA) or glucose.	Triiodothyronine	216-218	growth hormone releasing hormone	Bos taurus	17-20
2667643-5	1989	Triiodothyronine, alone or in the presence of insulin, increased lipogenesis and fatty acid synthase activity.	Triiodothyronine	0-16	insulin	Homo sapiens	46-53
2776749-11	1989	These data strongly suggested that the multi-functional 55-kDa protein which has triiodothyronine-binding activity and the activity of protein disulfide-isomerase, which is also reported to be the beta subunit of prolyl-4-hydroxylase, glycosylation-site-binding protein of oligosaccharyl transferase and iodothyronine 5"-monodeionidase, could be significant in the action of triiodothyronine towards the target cells.	Triiodothyronine	81-97	prolyl 4-hydroxylase subunit beta	Homo sapiens	135-162
2474323-2	1989	Our data showed that a marked inhibition (up to 8-fold) of alpha-fetoprotein secretion and an increase in albumin (up to 4-fold) are produced by 10(-8) M triiodothyronine.	Triiodothyronine	154-170	alpha fetoprotein	Homo sapiens	59-76
2776749-11	1989	These data strongly suggested that the multi-functional 55-kDa protein which has triiodothyronine-binding activity and the activity of protein disulfide-isomerase, which is also reported to be the beta subunit of prolyl-4-hydroxylase, glycosylation-site-binding protein of oligosaccharyl transferase and iodothyronine 5"-monodeionidase, could be significant in the action of triiodothyronine towards the target cells.	Triiodothyronine	375-391	prolyl 4-hydroxylase subunit beta	Homo sapiens	135-162
2474323-4	1989	However, an exposure of the cells to triiodothyronine for only the first 4 h was sufficient to affect, in a similar way, the secretion of alpha-fetoprotein and albumin when measured 15 days after treatment.	Triiodothyronine	37-53	alpha fetoprotein	Homo sapiens	138-155
2737142-0	1989	Heat shock of cultured GC cells enhances the level of triiodothyronine induced growth hormone (GH) and GH messenger ribonucleic acid.	Triiodothyronine	54-70	gonadotropin releasing hormone receptor	Rattus norvegicus	79-93
2590531-0	1989	Thioredoxin and glutaredoxin enhance the binding of L-triiodothyronine to its hepatic nuclear receptors.	Triiodothyronine	52-70	thioredoxin 1	Rattus norvegicus	0-11
2590531-0	1989	Thioredoxin and glutaredoxin enhance the binding of L-triiodothyronine to its hepatic nuclear receptors.	Triiodothyronine	52-70	glutaredoxin	Rattus norvegicus	16-28
2605796-6	1989	A statistically significant correlation between the ratio of the sex hormone binding globulin to the corticosteroid binding globulin and triiodothyronine levels was found (P less than 0.01).	Triiodothyronine	137-153	sex hormone binding globulin	Homo sapiens	65-93
2551809-1	1989	Thyroxine and triiodothyronine concentrations of 50 nM or lower can stimulate the chlorinating activity of the myeloperoxidase-H2O2-Cl- antimicrobial system in vitro.	Triiodothyronine	14-30	myeloperoxidase	Homo sapiens	111-126
2546966-1	1989	We have previously demonstrated that interferon-gamma (IFN-gamma) induced HLA-DR antigen and also inhibited thyrotropin (TSH)-induced triiodothyronine (T3) and thyroglobulin (Tg) secretion from cultured human thyrocytes.	Triiodothyronine	134-150	interferon gamma	Homo sapiens	55-64
2546966-1	1989	We have previously demonstrated that interferon-gamma (IFN-gamma) induced HLA-DR antigen and also inhibited thyrotropin (TSH)-induced triiodothyronine (T3) and thyroglobulin (Tg) secretion from cultured human thyrocytes.	Triiodothyronine	152-154	interferon gamma	Homo sapiens	55-64
2737142-5	1989	The enhanced T3-induced production of GH was coincident with a proportional increase (P less than 0.05) in cellular GH mRNA determined by dot hybridization analysis.	Triiodothyronine	13-15	gonadotropin releasing hormone receptor	Rattus norvegicus	38-40
2737142-5	1989	The enhanced T3-induced production of GH was coincident with a proportional increase (P less than 0.05) in cellular GH mRNA determined by dot hybridization analysis.	Triiodothyronine	13-15	gonadotropin releasing hormone receptor	Rattus norvegicus	116-118
2737142-0	1989	Heat shock of cultured GC cells enhances the level of triiodothyronine induced growth hormone (GH) and GH messenger ribonucleic acid.	Triiodothyronine	54-70	gonadotropin releasing hormone receptor	Rattus norvegicus	95-97
2504867-0	1989	Gonadotrophin-releasing hormone regulation of gonadotrophin subunit gene expression: studies in tri-iodothyronine-suppressed rats.	Triiodothyronine	96-113	gonadotropin releasing hormone 1	Rattus norvegicus	0-31
16726655-6	1989	The data also indicate that T(3) (possibly mediated by cAMP) may act on the ram sperm by the induction of enzymes, which are required for the well-known effects of this hormone in enhancing the sperm metabolic activity.	Triiodothyronine	28-32	cathelicidin antimicrobial peptide	Homo sapiens	55-59
2769150-1	1989	The effect of tri-iodothyronine (T3) treatment on myocardial levels of alpha and beta myosin heavy chain (MHC) mRNAs in the rat was defined in vivo and in vitro.	Triiodothyronine	14-31	myosin heavy chain 7	Rattus norvegicus	81-104
2769150-1	1989	The effect of tri-iodothyronine (T3) treatment on myocardial levels of alpha and beta myosin heavy chain (MHC) mRNAs in the rat was defined in vivo and in vitro.	Triiodothyronine	33-35	myosin heavy chain 7	Rattus norvegicus	81-104
2781147-2	1989	Serum total protein, thyroxine (T4), free T4, triiodothyronine (T3), and cytochrome P-450 and b5 were decreased significantly after CCl4 administration, whereas reverse T3 (rT3) was unchanged.	Triiodothyronine	46-62	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
2781147-2	1989	Serum total protein, thyroxine (T4), free T4, triiodothyronine (T3), and cytochrome P-450 and b5 were decreased significantly after CCl4 administration, whereas reverse T3 (rT3) was unchanged.	Triiodothyronine	64-66	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
2722789-5	1989	Thyroxine and triiodothyronine had inhibitory effects on myosin light chain kinase purified from human platelets and inhibited more markedly the myosin light chain kinase than protein kinase C (Ca2+/phospholipid-dependent enzyme) and cAMP-dependent protein kinase.	Triiodothyronine	14-30	myosin light chain kinase	Homo sapiens	57-82
2498379-6	1989	The potency of T4 analogs as inhibitors of T4 binding to isolated apoA-I was L-T4 = D-T4 = triiodothyroacetic acid = L-rT3 much greater than L-T3 much greater than L-thyronine.	Triiodothyronine	120-122	apolipoprotein A1	Homo sapiens	66-72
19210452-0	1989	Triiodothyronine regulates insulin-like growth factor-I binding to cultured rat pituitary cells.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	27-55
19210452-10	1989	Dexamethasone (10(-7)M) inhibited the T(3)-induced increase in IGF-I binding, but glucocorticoid alone did not substantially alter receptor number.	Triiodothyronine	38-42	insulin-like growth factor 1	Rattus norvegicus	63-68
2500121-0	1989	The effect of triiodothyronine on the association of the rat apolipoprotein A-I, C-III and A-IV genes with the nuclear matrix.	Triiodothyronine	14-30	apolipoprotein A1	Rattus norvegicus	61-79
2502597-3	1989	TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release.	Triiodothyronine	156-158	thyrotropin releasing hormone	Rattus norvegicus	0-3
2502597-3	1989	TRH (1 nmol/l)-induced TSH release over 1 h was enhanced by 70% (P less than 0.01) following exposure to 10 nmol 1,25-(OH)2D3/l for 24 h. Pretreatment with T3 (1 pmol/l-1 mumol/l) for 24 h caused a dose-dependent inhibition of TRH-induced TSH release.	Triiodothyronine	156-158	thyrotropin releasing hormone	Rattus norvegicus	227-230
2502597-6	1989	The increment of TRH-induced TSH release resulting from 1,25-(OH)2D3 pretreatment was equivalent in the presence or absence of maximal inhibitory T3 concentrations.	Triiodothyronine	146-148	thyrotropin releasing hormone	Rattus norvegicus	17-20
2503407-1	1989	We have previously demonstrated in rat thymocyte plasma membranes that adenylate cyclase activity and its stimulation by 3,5,3"-triiodothyronine (T3) are influenced by calmodulin, and that these effects of calmodulin require calcium.	Triiodothyronine	121-144	calmodulin 1	Rattus norvegicus	168-178
2503407-1	1989	We have previously demonstrated in rat thymocyte plasma membranes that adenylate cyclase activity and its stimulation by 3,5,3"-triiodothyronine (T3) are influenced by calmodulin, and that these effects of calmodulin require calcium.	Triiodothyronine	121-144	calmodulin 1	Rattus norvegicus	206-216
2503407-1	1989	We have previously demonstrated in rat thymocyte plasma membranes that adenylate cyclase activity and its stimulation by 3,5,3"-triiodothyronine (T3) are influenced by calmodulin, and that these effects of calmodulin require calcium.	Triiodothyronine	146-148	calmodulin 1	Rattus norvegicus	168-178
2503407-1	1989	We have previously demonstrated in rat thymocyte plasma membranes that adenylate cyclase activity and its stimulation by 3,5,3"-triiodothyronine (T3) are influenced by calmodulin, and that these effects of calmodulin require calcium.	Triiodothyronine	146-148	calmodulin 1	Rattus norvegicus	206-216
2722789-5	1989	Thyroxine and triiodothyronine had inhibitory effects on myosin light chain kinase purified from human platelets and inhibited more markedly the myosin light chain kinase than protein kinase C (Ca2+/phospholipid-dependent enzyme) and cAMP-dependent protein kinase.	Triiodothyronine	14-30	myosin light chain kinase	Homo sapiens	145-170
2473388-1	1989	We have used in vitro explant cultures of Xenopus laevis skin to investigate the role that the thyroid hormone triiodothyronine (T3) plays in activating the 63-kilodalton (kDa) keratin genes.	Triiodothyronine	111-127	70a	Xenopus laevis	177-184
2473388-1	1989	We have used in vitro explant cultures of Xenopus laevis skin to investigate the role that the thyroid hormone triiodothyronine (T3) plays in activating the 63-kilodalton (kDa) keratin genes.	Triiodothyronine	129-131	70a	Xenopus laevis	177-184
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	75-91	thyroid stimulating hormone receptor	Mus musculus	28-31
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	139-155	prolactin	Rattus norvegicus	5-8
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	139-155	prolactin	Rattus norvegicus	228-231
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	139-155	prolactin	Rattus norvegicus	228-231
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	157-159	prolactin	Rattus norvegicus	5-8
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	157-159	prolactin	Rattus norvegicus	228-231
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Triiodothyronine	157-159	prolactin	Rattus norvegicus	228-231
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	75-91	thyroid stimulating hormone receptor	Mus musculus	32-35
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	75-91	thyroid stimulating hormone receptor	Mus musculus	32-35
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	93-95	thyroid stimulating hormone receptor	Mus musculus	28-31
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	93-95	thyroid stimulating hormone receptor	Mus musculus	32-35
2725843-6	1989	Through their lifetime, the hyt/hyt mice had reduced serum thyroxine (T4), triiodothyronine (T3), reduced thyroid gland intralumenal colloid on electron microscopy and a 100-fold elevation of TSH-like activity compared to hyt/+ littermates.	Triiodothyronine	93-95	thyroid stimulating hormone receptor	Mus musculus	32-35
2563727-5	1989	In this study, we also discovered that T3 (triiodothyronine) exerts synergistic control on the action of EGF alone or in association with TGF-beta 1, on EGF-R and c-erbB-2 gene transcription.	Triiodothyronine	43-59	transforming growth factor beta 1	Homo sapiens	138-148
2719684-4	1989	Administration of L-triiodothyronine (T3, 50 micrograms/kg) or human growth hormone (4 U/kg) reversed almost completely the increased amounts of P-450b and P-450e.	Triiodothyronine	18-36	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	145-151
2719684-4	1989	Administration of L-triiodothyronine (T3, 50 micrograms/kg) or human growth hormone (4 U/kg) reversed almost completely the increased amounts of P-450b and P-450e.	Triiodothyronine	38-40	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	145-151
2752394-2	1989	Selection and cloning were used to look up the T3-01 hybridoma producing a monoclonal antibody of the IgG1 subclass which responded in a radioimmunoassay specifically to triiodothyronine.	Triiodothyronine	170-186	LOC105243590	Mus musculus	102-106
2497223-0	1989	Effects of hypothyroidism, tri-iodothyronine and glucocorticoids on growth hormone responses to growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Triiodothyronine	27-44	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
2497223-0	1989	Effects of hypothyroidism, tri-iodothyronine and glucocorticoids on growth hormone responses to growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Triiodothyronine	27-44	growth hormone releasing hormone	Rattus norvegicus	96-128
2495002-2	1989	The evidence indicates that TBG bears the serum lowest capacity highest affinity sites for thyroxine (T4) and triiodothyronine (T3) (Ka1 greater than or equal to 10(9) M-1) as well as weaker saturable T3 sites (Ka2 approximately 10(8) M-1).	Triiodothyronine	110-126	serpin family A member 7	Rattus norvegicus	28-31
2495002-2	1989	The evidence indicates that TBG bears the serum lowest capacity highest affinity sites for thyroxine (T4) and triiodothyronine (T3) (Ka1 greater than or equal to 10(9) M-1) as well as weaker saturable T3 sites (Ka2 approximately 10(8) M-1).	Triiodothyronine	128-130	serpin family A member 7	Rattus norvegicus	28-31
2495002-4	1989	Consistent with these parameters are the specific responses of TBG and TBPA binding activities to varying serum concentrations of T4, T3, oleic acid, the drugs diphenylhydantoin or salicylate.	Triiodothyronine	134-136	serpin family A member 7	Rattus norvegicus	63-66
2495002-4	1989	Consistent with these parameters are the specific responses of TBG and TBPA binding activities to varying serum concentrations of T4, T3, oleic acid, the drugs diphenylhydantoin or salicylate.	Triiodothyronine	134-136	transthyretin	Rattus norvegicus	71-75
2925662-1	1989	The mRNA coding for the rat liver S14 protein (Mr 17,000; pI 4.9) is rapidly induced by triiodothyronine (T3) (Jump, D. B., Narayan, P., Towle, H. C., and Oppenheimer, J. H. (1984) J. Biol.	Triiodothyronine	88-104	thyroid hormone responsive	Rattus norvegicus	34-37
2925662-1	1989	The mRNA coding for the rat liver S14 protein (Mr 17,000; pI 4.9) is rapidly induced by triiodothyronine (T3) (Jump, D. B., Narayan, P., Towle, H. C., and Oppenheimer, J. H. (1984) J. Biol.	Triiodothyronine	106-108	thyroid hormone responsive	Rattus norvegicus	34-37
2563727-5	1989	In this study, we also discovered that T3 (triiodothyronine) exerts synergistic control on the action of EGF alone or in association with TGF-beta 1, on EGF-R and c-erbB-2 gene transcription.	Triiodothyronine	43-59	epidermal growth factor receptor	Homo sapiens	153-158
2563727-5	1989	In this study, we also discovered that T3 (triiodothyronine) exerts synergistic control on the action of EGF alone or in association with TGF-beta 1, on EGF-R and c-erbB-2 gene transcription.	Triiodothyronine	43-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	163-171
2563758-0	1989	Regulation of thyrotropin releasing hormone degrading enzymes in rat brain and pituitary by L-3,5,3"-triiodothyronine.	Triiodothyronine	92-117	thyrotropin releasing hormone	Rattus norvegicus	14-43
2564008-14	1989	The residual PRL responses were negatively correlated with free triiodothyronine levels and positively with serotonergic variables, i.e., 5-hydroxyindoleacetic acid in 24-h urine and the ratio L-tryptophan/competing amino acids.	Triiodothyronine	64-80	prolactin	Homo sapiens	13-16
2494101-0	1989	Triiodothyronine inhibition of thyrotropin-releasing hormone- and growth hormone-releasing factor-induced growth hormone secretion in anesthetized chickens.	Triiodothyronine	0-16	thyrotropin releasing hormone	Gallus gallus	31-60
2494101-0	1989	Triiodothyronine inhibition of thyrotropin-releasing hormone- and growth hormone-releasing factor-induced growth hormone secretion in anesthetized chickens.	Triiodothyronine	0-16	growth hormone	Gallus gallus	66-80
2494101-0	1989	Triiodothyronine inhibition of thyrotropin-releasing hormone- and growth hormone-releasing factor-induced growth hormone secretion in anesthetized chickens.	Triiodothyronine	0-16	growth hormone	Gallus gallus	106-120
2494101-1	1989	The ability of triiodothyronine (T3) to reduce basal and secretagogue-induced growth hormone (GH) release was examined in anesthetized young and adult male chickens.	Triiodothyronine	15-31	growth hormone	Gallus gallus	78-92
2494101-1	1989	The ability of triiodothyronine (T3) to reduce basal and secretagogue-induced growth hormone (GH) release was examined in anesthetized young and adult male chickens.	Triiodothyronine	33-35	growth hormone	Gallus gallus	78-92
2563758-1	1989	The effect of treatment with L-3,5,3"-triiodothyronine (T3) on the levels of pyroglutamyl peptidase I and pyroglutamyl peptidase II in rat brain regions, pituitary, and serum was studied.	Triiodothyronine	29-54	thyrotropin-releasing hormone degrading enzyme	Rattus norvegicus	106-131
2563758-1	1989	The effect of treatment with L-3,5,3"-triiodothyronine (T3) on the levels of pyroglutamyl peptidase I and pyroglutamyl peptidase II in rat brain regions, pituitary, and serum was studied.	Triiodothyronine	56-58	thyrotropin-releasing hormone degrading enzyme	Rattus norvegicus	106-131
2909366-2	1989	We sought to identify the cellular localization of angiotensinogen mRNA in these two tissues using hybridization in situ of tissues obtained from both control rats and rats administered a combination of dexamethasone, ethynylestradiol, and T3.	Triiodothyronine	240-242	angiotensinogen	Rattus norvegicus	51-66
2914019-2	1989	These data, which correct an erroneous report of pK3 in the literature, have been used to estimate the ionization constants of the thyroid hormone L-3",3,5-tri-iodothyronine (T3).	Triiodothyronine	147-173	pyruvate kinase M1/2	Rattus norvegicus	49-52
2914019-2	1989	These data, which correct an erroneous report of pK3 in the literature, have been used to estimate the ionization constants of the thyroid hormone L-3",3,5-tri-iodothyronine (T3).	Triiodothyronine	175-177	pyruvate kinase M1/2	Rattus norvegicus	49-52
2776437-6	1989	During triiodothyronine-induced metamorphosis of Alytes larvae, catalase and D-amino acid oxidase activities increased after a latent period.	Triiodothyronine	7-23	LOC100174793	Xenopus laevis	64-72
2713334-7	1989	Analysis of binding data indicates that p58 binds to 3,3",5-triiodo-L-thyronine (T3) with a Kd of 24.3 +/- 0.3 nM and n = 0.71.	Triiodothyronine	81-83	cyclin dependent kinase 11B	Homo sapiens	40-43
2768003-1	1989	Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in livers of triiodothyronine (T3) treated male and female rats with special regard to its intraacinar localization.	Triiodothyronine	81-97	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-33
2485831-0	1989	Effect of triiodothyronine on the muscarinic receptors and acetylcholinesterase activity of developing rat brain.	Triiodothyronine	10-26	acetylcholinesterase	Rattus norvegicus	59-79
2491856-0	1989	A new inherited abnormality of thyroxine-binding globulin (TBG-San Diego) with decreased affinity for thyroxine and triiodothyronine.	Triiodothyronine	116-132	serpin family A member 7	Homo sapiens	31-57
2491856-0	1989	A new inherited abnormality of thyroxine-binding globulin (TBG-San Diego) with decreased affinity for thyroxine and triiodothyronine.	Triiodothyronine	116-132	serpin family A member 7	Homo sapiens	59-62
2560512-4	1989	It was only found in hepatoma cells where it is regulated by estradiol, antiestrogen tamoxifen and triiodothyronine, in a similar way as secreted SBP.	Triiodothyronine	99-115	selenium binding protein 1	Homo sapiens	146-149
2768003-1	1989	Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in livers of triiodothyronine (T3) treated male and female rats with special regard to its intraacinar localization.	Triiodothyronine	81-97	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	35-40
2768003-1	1989	Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in livers of triiodothyronine (T3) treated male and female rats with special regard to its intraacinar localization.	Triiodothyronine	99-101	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-33
2768003-1	1989	Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in livers of triiodothyronine (T3) treated male and female rats with special regard to its intraacinar localization.	Triiodothyronine	99-101	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	35-40
2922106-8	1989	In summary, the sensitive and specific technique of measuring the release of anti-T4-bound radioiodine in vivo after pretreatment with NA 125I and T3 detected a stimulation of the thyroid hormone secretion by VIP and helodermin.	Triiodothyronine	147-149	vasoactive intestinal polypeptide	Mus musculus	209-212
2789414-0	1989	Effects of triiodothyronine (T3) on the potentiation by antidepressants of L-5-hydroxytryptophan-induced head-twitches in mice.	Triiodothyronine	11-27	kinocilin	Mus musculus	75-78
2789414-0	1989	Effects of triiodothyronine (T3) on the potentiation by antidepressants of L-5-hydroxytryptophan-induced head-twitches in mice.	Triiodothyronine	29-31	kinocilin	Mus musculus	75-78
3168921-0	1988	Triiodothyronine rapidly reverses inhibition of S14 gene transcription by glucagon.	Triiodothyronine	0-16	thyroid hormone responsive	Rattus norvegicus	48-51
3192531-0	1988	Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.	Triiodothyronine	0-16	uncoupling protein 1	Rattus norvegicus	57-75
3201478-4	1988	The large elevations of leucine aminopeptidase (LAP) at 1 mg/kg L-T3 in monkey indicated hepatocellular toxicity although in the rat such large increases in alanine aminotransferase (ALT) and glutamate dehydrogenase (GLDH) were not seen.	Triiodothyronine	64-68	leucine aminopeptidase 3	Rattus norvegicus	24-46
3201478-4	1988	The large elevations of leucine aminopeptidase (LAP) at 1 mg/kg L-T3 in monkey indicated hepatocellular toxicity although in the rat such large increases in alanine aminotransferase (ALT) and glutamate dehydrogenase (GLDH) were not seen.	Triiodothyronine	64-68	leucine aminopeptidase 3	Rattus norvegicus	48-51
3136772-0	1988	The effect of triiodothyronine on rat apolipoprotein A-I and A-IV gene transcription.	Triiodothyronine	14-30	apolipoprotein A1	Rattus norvegicus	38-56
3073038-8	1988	Injections of thyroxine or triiodothyronine decreased the plasma concentration of GH but were without effect on the plasma concentration of SmC.	Triiodothyronine	27-43	growth hormone	Gallus gallus	82-84
3139393-0	1988	Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus.	Triiodothyronine	0-16	thyrotropin releasing hormone	Rattus norvegicus	59-88
3149287-2	1988	When compared to those of chow-fed controls, rates of synthesis of intestinal apoA-I and apoB-48 decreased 60-66% in hypothyroid animals and increased three- to fourfold after triiodothyronine (T3) administration.	Triiodothyronine	176-192	apolipoprotein A1	Rattus norvegicus	78-84
3142321-7	1988	Concentrations of T3 doubled in 5 of 10, 2 of 10, and 5 of 10 dogs given TSH, freshly reconstituted TRH, or previously frozen TRH, respectively.	Triiodothyronine	18-20	TRH	Canis lupus familiaris	100-103
3142321-7	1988	Concentrations of T3 doubled in 5 of 10, 2 of 10, and 5 of 10 dogs given TSH, freshly reconstituted TRH, or previously frozen TRH, respectively.	Triiodothyronine	18-20	TRH	Canis lupus familiaris	126-129
3179753-3	1988	The addition of L-triiodothyronine (L-T3) at a concentration of 3 x 10(-8) M at the initiation of the culture had no effect on the number of AChE+ cells but significantly increased the size and neurite length of AChE+ neurons after 5 days in vitro.	Triiodothyronine	16-34	acetylcholinesterase	Rattus norvegicus	212-216
3179753-3	1988	The addition of L-triiodothyronine (L-T3) at a concentration of 3 x 10(-8) M at the initiation of the culture had no effect on the number of AChE+ cells but significantly increased the size and neurite length of AChE+ neurons after 5 days in vitro.	Triiodothyronine	36-40	acetylcholinesterase	Rattus norvegicus	212-216
3179753-5	1988	L-T3 increased AChE activity in both a dose- and time-dependent manner (the stimulatory effect of L-T3 becomes significant between day 8 and day 15).	Triiodothyronine	1-4	acetylcholinesterase	Rattus norvegicus	15-19
3179753-9	1988	Studies of the time necessary for L-T3 to increase both ChAT and AChE activities show that 2 days and 15 days, respectively, are required for L-T3 to significantly stimulate both enzyme activities.	Triiodothyronine	34-38	acetylcholinesterase	Rattus norvegicus	65-69
3179753-9	1988	Studies of the time necessary for L-T3 to increase both ChAT and AChE activities show that 2 days and 15 days, respectively, are required for L-T3 to significantly stimulate both enzyme activities.	Triiodothyronine	142-146	acetylcholinesterase	Rattus norvegicus	65-69
3140808-1	1988	3,3",5-L-triiodothyronine (T3) can inhibit tyrosinase activity in B16/C3 melanoma cells in culture and block the induction of that enzyme by imidazole (Endocrinol.	Triiodothyronine	27-29	tyrosinase	Mus musculus	43-53
3136772-1	1988	The effects of triiodothyronine administration on the mRNA levels of apolipoprotein (apo)A-I, apo A-IV and albumin were determined in extracts of rat liver by hybridization to specific cDNA.	Triiodothyronine	15-31	apolipoprotein A4	Rattus norvegicus	94-102
3136772-2	1988	The mRNA levels for apo A-I and apo A-IV in the rat liver increased to 347% and 143% of normal, respectively, following a single injection of triiodothyronine (50 microgram/100g body weight).	Triiodothyronine	142-158	apolipoprotein A1	Rattus norvegicus	20-40
3132915-0	1988	Stimulation of intestinal secretion of apolipoprotein AI by triiodothyronine.	Triiodothyronine	60-76	apolipoprotein A1	Rattus norvegicus	39-56
3044137-4	1988	During hyperglycemia, 3,5,3"-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates.	Triiodothyronine	22-45	insulin	Homo sapiens	138-145
3044137-4	1988	During hyperglycemia, 3,5,3"-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates.	Triiodothyronine	47-49	insulin	Homo sapiens	138-145
3141256-5	1988	In all experiments there was a concomitant triiodothyronine (T3) increase after TRH injection, but differences between experimental groups were observed at days 15 and 19 of incubation and immediately after the postnatal temperature treatment.	Triiodothyronine	43-59	thyrotropin releasing hormone	Gallus gallus	80-83
3211156-0	1988	Full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine.	Triiodothyronine	90-106	uncoupling protein 1	Rattus norvegicus	19-29
2838266-4	1988	About 30-55% of the newly synthesized [35S]TBG immunoprecipitated with anti-TBG serum was inhibited by 10(-8) M T3.	Triiodothyronine	112-114	serpin family A member 7	Homo sapiens	43-46
2838266-4	1988	About 30-55% of the newly synthesized [35S]TBG immunoprecipitated with anti-TBG serum was inhibited by 10(-8) M T3.	Triiodothyronine	112-114	serpin family A member 7	Homo sapiens	76-79
3162871-0	1988	Triiodothyronine: a substrate for the thermostable and thermolabile forms of human phenol sulfotransferase.	Triiodothyronine	0-16	sulfotransferase family 1A member 1	Homo sapiens	83-106
3136801-1	1988	The differential availability of thyroxine (T4) and 3,5,3"-triiodothyronine (T3) to liver from the circulating thyroid hormone binding globulin (TBG)-bound pool suggests that the two thyroid hormones may bind to different TBG isoforms in human serum.	Triiodothyronine	52-75	serpin family A member 7	Homo sapiens	145-148
3136801-1	1988	The differential availability of thyroxine (T4) and 3,5,3"-triiodothyronine (T3) to liver from the circulating thyroid hormone binding globulin (TBG)-bound pool suggests that the two thyroid hormones may bind to different TBG isoforms in human serum.	Triiodothyronine	52-75	serpin family A member 7	Homo sapiens	222-225
3136801-1	1988	The differential availability of thyroxine (T4) and 3,5,3"-triiodothyronine (T3) to liver from the circulating thyroid hormone binding globulin (TBG)-bound pool suggests that the two thyroid hormones may bind to different TBG isoforms in human serum.	Triiodothyronine	77-79	serpin family A member 7	Homo sapiens	145-148
2840173-3	1988	Intraperitoneal injections of triiodothyronine for 8 weeks resulted in a selective 41% increase (P less than 0.02) in retinal TRH receptor levels without any changes in the pituitary and 4 other brain regions.	Triiodothyronine	30-46	thyrotropin releasing hormone	Rattus norvegicus	126-129
3360797-2	1988	We have previously described a photoaffinity label derivative of 3,5,3"-triiodo-L-thyronine (L-T3) in which the alanine side chain was modified to form N-2-diazo-3,3,3-trifluoropropionyl-L-T3 (L-[125I]T3-PAL).	Triiodothyronine	93-97	leucine-rich repeat, Ig-like and transmembrane domains 1	Rattus norvegicus	204-207
3128768-1	1988	Thyroxine-binding globulin (TBG) excess with increased total thyroxine (T4) and triiodothyronine (T3) levels has not been thought to produce symptoms.	Triiodothyronine	80-96	serpin family A member 7	Homo sapiens	0-26
3359971-7	1988	The administration of a large single dose of T3 (50 micrograms/100 g BW) produced a significant (P less than 0.001) increase in ALAS activity 72 h later.	Triiodothyronine	45-47	5'-aminolevulinate synthase 1	Rattus norvegicus	128-132
3403362-0	1988	Serum levels of total testosterone and sex hormone binding globulin in hypothyroid patients and normal subjects treated with incremental doses of L-T4 or L-T3.	Triiodothyronine	154-158	sex hormone binding globulin	Homo sapiens	39-67
3396755-1	1988	Binding of semi-purified rat liver triiodothyronine (T3) nuclear receptor (T3-nR) to sequences in the 5" flanking DNA of rat growth hormone (rGH) has been evaluated by the DNAse-footprinting technique.	Triiodothyronine	35-51	gonadotropin releasing hormone receptor	Rattus norvegicus	125-139
3128768-0	1988	Short stature and thyroxine-binding globulin excess: improvement with triiodothyronine treatment.	Triiodothyronine	70-86	serpin family A member 7	Homo sapiens	18-44
3128768-1	1988	Thyroxine-binding globulin (TBG) excess with increased total thyroxine (T4) and triiodothyronine (T3) levels has not been thought to produce symptoms.	Triiodothyronine	80-96	serpin family A member 7	Homo sapiens	28-31
3128768-1	1988	Thyroxine-binding globulin (TBG) excess with increased total thyroxine (T4) and triiodothyronine (T3) levels has not been thought to produce symptoms.	Triiodothyronine	98-100	serpin family A member 7	Homo sapiens	0-26
3128768-1	1988	Thyroxine-binding globulin (TBG) excess with increased total thyroxine (T4) and triiodothyronine (T3) levels has not been thought to produce symptoms.	Triiodothyronine	98-100	serpin family A member 7	Homo sapiens	28-31
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	21-39	myosin light chain kinase	Homo sapiens	69-94
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	21-39	myosin light chain kinase	Homo sapiens	96-106
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	21-39	calmodulin 1	Homo sapiens	289-299
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	41-43	myosin light chain kinase	Homo sapiens	69-94
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	41-43	myosin light chain kinase	Homo sapiens	96-106
3358764-1	1988	L-Thyroxine (T4) and L-triiodothyronine (T3) specifically, inhibited myosin light chain kinase (MLC-kinase) from various tissues whereas inhibitory effects of T4 and T3 on other protein kinases such as protein kinase C, cAMP-dependent protein kinase, casein kinase I, casein kinase II and calmodulin kinase II were much weaker.	Triiodothyronine	41-43	calmodulin 1	Homo sapiens	289-299
2966870-4	1988	Serum T4, T3 concentrations showed significant correlation with PaO2, serum albumin, and serum cholinesterase.	Triiodothyronine	10-12	albumin	Homo sapiens	70-83
3349095-1	1988	We previously reported that administration of dexamethasone to the pregnant dam increased the activity of fatty-acid synthase (EC 2.3.1.85) in fetal rat lung and that this effect was reduced when triiodothyronine (T3) was also administered.	Triiodothyronine	196-212	fatty acid synthase	Rattus norvegicus	106-125
3349095-1	1988	We previously reported that administration of dexamethasone to the pregnant dam increased the activity of fatty-acid synthase (EC 2.3.1.85) in fetal rat lung and that this effect was reduced when triiodothyronine (T3) was also administered.	Triiodothyronine	214-216	fatty acid synthase	Rattus norvegicus	106-125
3130285-1	1988	While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3).	Triiodothyronine	201-217	growth hormone 1	Homo sapiens	121-123
3130285-1	1988	While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3).	Triiodothyronine	219-221	growth hormone 1	Homo sapiens	121-123
2892854-1	1988	A reverse hemolytic plaque assay was used to measure the GH responses of fetal pituitary cells to GHRH, SRIH, T3 and glucocorticoids.	Triiodothyronine	110-112	growth hormone 1	Homo sapiens	57-59
3288226-2	1988	The presence of 1-100 nM triiodothyronine (T3) in the second incubation significantly increased binding of human 125I-LDL to the LDL receptor.	Triiodothyronine	25-41	low density lipoprotein receptor	Homo sapiens	129-141
3288226-2	1988	The presence of 1-100 nM triiodothyronine (T3) in the second incubation significantly increased binding of human 125I-LDL to the LDL receptor.	Triiodothyronine	43-45	low density lipoprotein receptor	Homo sapiens	129-141
3346361-7	1988	In individual women serum hCG correlated negatively with TSH (r = 0.322; P = 0.005) and positively with free T3 (r = 0.388; P less than 0.001).	Triiodothyronine	109-111	chorionic gonadotropin subunit beta 5	Homo sapiens	26-29
3260858-3	1988	Serum BGP had a significant positive correlation with the concentrations of free triiodothyronine and alkaline phosphatase in the serum, while it had a significant negative correlation with serum PTH.	Triiodothyronine	81-97	bone gamma-carboxyglutamate protein	Homo sapiens	6-9
3260858-4	1988	In the patients with hypothyroidism, serum BGP increased significantly in parallel with increases in serum free triiodothyronine with thyroxine therapy.	Triiodothyronine	112-128	bone gamma-carboxyglutamate protein	Homo sapiens	43-46
2966870-4	1988	Serum T4, T3 concentrations showed significant correlation with PaO2, serum albumin, and serum cholinesterase.	Triiodothyronine	10-12	butyrylcholinesterase	Homo sapiens	95-109
3342325-0	1988	Triiodothyronine (T3) induces neurite formation and increases synthesis of a protein related to MAP 1B in cultured cells of neuronal origin.	Triiodothyronine	0-16	microtubule-associated protein 1B	Mus musculus	96-102
2826461-7	1988	To understand the role p55 plays in thyroid hormone action, we examined the regulation of p55 by 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	97-123	Cd4 molecule	Rattus norvegicus	90-93
2826461-7	1988	To understand the role p55 plays in thyroid hormone action, we examined the regulation of p55 by 3,3",5-triiodo-L-thyronine (T3).	Triiodothyronine	125-127	Cd4 molecule	Rattus norvegicus	90-93
3342325-0	1988	Triiodothyronine (T3) induces neurite formation and increases synthesis of a protein related to MAP 1B in cultured cells of neuronal origin.	Triiodothyronine	18-20	microtubule-associated protein 1B	Mus musculus	96-102
3422065-0	1988	Effects of inhibition of type I iodothyronine deiodinase and phenol sulfotransferase on the biliary clearance of triiodothyronine in rats.	Triiodothyronine	113-129	iodothyronine deiodinase 1	Rattus norvegicus	25-56
3273626-1	1988	Triiodothyronine administration to thyroidectomized animals, decreased cytochrome P-450 content by 50%.	Triiodothyronine	0-16	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	71-87
2446606-2	1987	We show that in the sera of postnatal developing animals, the thyroxine and the triiodothyronine binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TBG.	Triiodothyronine	80-96	serpin family A member 7	Rattus norvegicus	221-224
3273626-7	1988	Our results suggest that under triiodothyronine stimulation, the decrease in cytochrome P-450 content is not due to an enhanced rate of degradation of the haem moiety, but it rather dissociates to increase the cellular haem pool, and saturates in part the newly synthesized apotryptophan pyrrolase.	Triiodothyronine	31-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
3320054-4	1987	alpha-MHC gene expression is up-regulated by injecting L-triiodothyronine (100 micrograms/kg per d) for 1-4 d. This protocol provides a means by which to follow the redistribution pattern of alpha-MHC within the myocyte in vivo.	Triiodothyronine	55-73	myosin-6-like	Oryctolagus cuniculus	0-9
3320054-4	1987	alpha-MHC gene expression is up-regulated by injecting L-triiodothyronine (100 micrograms/kg per d) for 1-4 d. This protocol provides a means by which to follow the redistribution pattern of alpha-MHC within the myocyte in vivo.	Triiodothyronine	55-73	myosin-6-like	Oryctolagus cuniculus	191-200
3077476-0	1988	[Evaluation of 3 different methods for determining triiodothyronine (T-3) and thyroxine (T-4)].	Triiodothyronine	51-67	solute carrier family 25 member 5	Homo sapiens	69-72
3427094-5	1987	The binding of the thyroid hormone triiodothyronine to beta 1 gamma 1 ADH is mutually exclusive with 1,10-phenanthroline, 4-methylpyrazole, and testosterone, identifying a binding site(s) for the thyroid hormones, which overlap(s) both the 1,10-phenanthroline site near the active site zinc atom and the testosterone binding site, the latter being a regulatory site on the gamma-subunit-containing isozymes and distinct from their catalytic site.	Triiodothyronine	35-51	aldo-keto reductase family 1 member A1	Homo sapiens	70-73
3127514-0	1987	Thyroid status affects the regulation of prolactin mRNA accumulation by tri-iodothyronine and thyrotrophin-releasing hormone in cultured rat anterior pituitary cells.	Triiodothyronine	72-89	prolactin	Rattus norvegicus	41-50
2446606-3	1987	In the adult serum, the TBG persists in decreased amounts: it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone.	Triiodothyronine	191-207	serpin family A member 7	Rattus norvegicus	24-27
3313046-1	1987	The substance 3,5,3-triiodothyronine (T3) stimulates growth hormone gene transcription in rat pituitary tumour cells.	Triiodothyronine	38-40	gonadotropin releasing hormone receptor	Rattus norvegicus	53-67
3688223-1	1987	The rapid and marked response of hepatic mRNA-S14 sequence to both triiodothyronine and carbohydrate intake has made this sequence an attractive model for studying the action of hormonal and dietary factors.	Triiodothyronine	67-83	thyroid hormone responsive	Rattus norvegicus	46-49
3325607-2	1987	In the in-vitro system, angiotensinogen production rate (APR) of monolayer cultures of rat hepatocytes in response to tri-iodothyronine (T3) and thyroxine (T4) was assayed.	Triiodothyronine	118-135	angiotensinogen	Rattus norvegicus	24-39
3325607-2	1987	In the in-vitro system, angiotensinogen production rate (APR) of monolayer cultures of rat hepatocytes in response to tri-iodothyronine (T3) and thyroxine (T4) was assayed.	Triiodothyronine	137-139	angiotensinogen	Rattus norvegicus	24-39
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	125-143	calmodulin-3	Sus scrofa	0-10
3118365-4	1987	Treatment with exogenous L-triiodothyronine (T3) reduced TRH mRNA to the same level in both hypothyroid and euthyroid animals.	Triiodothyronine	25-43	thyrotropin releasing hormone	Rattus norvegicus	57-60
3118365-4	1987	Treatment with exogenous L-triiodothyronine (T3) reduced TRH mRNA to the same level in both hypothyroid and euthyroid animals.	Triiodothyronine	45-47	thyrotropin releasing hormone	Rattus norvegicus	57-60
3426630-4	1987	In contrast, certain enzymes involve in lipogenesis, ATP-citrate lyase "malic" enzyme and 6-phosphogluconate dehydrogenase, which were decreased in activity in diabetes, were increased to, or above, control values when diabetic rats were treated with T3.	Triiodothyronine	251-253	ATP citrate lyase	Rattus norvegicus	53-70
2856412-1	1987	The mRNA of the rat hepatic S14 gene accumulates rapidly after administration of T3 and carbohydrate, making it an excellent model for studies of the effects of dietary and hormonal stimuli at the hepatocellular level.	Triiodothyronine	81-83	thyroid hormone responsive	Rattus norvegicus	28-31
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	125-143	calmodulin-3	Sus scrofa	98-108
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	125-143	calmodulin-3	Sus scrofa	114-124
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	127-143	calmodulin-3	Sus scrofa	0-10
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	127-143	calmodulin-3	Sus scrofa	98-108
2822507-5	1987	Calmodulin activation of cyclic AMP phosphodiesterase decreased when iodothyronines were bound to calmodulin; the calmodulin-L-triiodothyronine complex was the most active among the stereoisomers of thyroxine and triiodothyronine.	Triiodothyronine	127-143	calmodulin-3	Sus scrofa	114-124
2822507-6	1987	These results suggest that, when triiodothyronine was bound to Ca2+-calmodulin, the activation of cyclic AMP phosphodiesterase by the latter is suppressed.	Triiodothyronine	33-49	calmodulin-3	Sus scrofa	68-78
3595529-2	1987	We have used the Reuber H35 (H4IIE) rat hepatoma cell line to study the regulation of angiotensinogen mRNA levels by dexamethasone, aldosterone, L-T3, and 17 beta-estradiol.	Triiodothyronine	145-149	angiotensinogen	Rattus norvegicus	86-101
3615409-1	1987	Experiments were conducted to evaluate the possible role of circulating growth hormones triiodothyronine (T3), thyroxine (T4), and insulin-like growth factor I (somatomedin-C; IGF-I) in the elevation of plasma growth hormone (GH) which occurs in protein-restricted chickens.	Triiodothyronine	88-104	growth hormone	Gallus gallus	72-86
3597704-0	1987	Resistance to thyroid hormone diagnosed by the reduced response of fibroblasts to the triiodothyronine-induced suppression of fibronectin synthesis.	Triiodothyronine	86-102	fibronectin 1	Homo sapiens	126-137
3471759-1	1987	In GC cells, a growth hormone-producing rat pituitary cell line, 3,5,3"-triiodo-L-thyronine (L-T3) rapidly stimulates the transcription rate of the growth hormone gene which parallels the level of chromatin-associated L-T3-receptor complexes (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	95-97	gonadotropin releasing hormone receptor	Rattus norvegicus	148-162
3153479-8	1987	Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes.	Triiodothyronine	37-39	insulin	Homo sapiens	238-245
3153479-8	1987	Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes.	Triiodothyronine	37-39	insulin	Homo sapiens	353-360
16726305-0	1987	Growth response, reproductive activity, and serum growth hormone in fine-wool ewe lambs treated with triiodothyronine.	Triiodothyronine	101-117	somatotropin	Ovis aries	50-64
2959271-10	1987	However, exposure of minced pieces of hearts of hypothyroid rats to tri-iodothyronine for 5 h resulted in a clear increase in phosphofructokinase-1 activity, which was partially prevented by the simultaneous addition of cycloheximide.	Triiodothyronine	68-85	phosphofructokinase, liver type	Rattus norvegicus	126-147
3623420-0	1987	Growth hormone stimulates the peripheral conversion of thyroxine into triiodothyronine by increasing the liver 5"-monodeiodinase activity in the fasted and normal fed chicken.	Triiodothyronine	70-86	growth hormone	Gallus gallus	0-14
3584469-0	1987	L-triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth-hormone-producing cell line.	Triiodothyronine	0-18	growth hormone 1	Homo sapiens	83-97
3584469-1	1987	L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3-responsive growth hormone (GH)-secreting cell line.	Triiodothyronine	0-18	growth hormone 1	Homo sapiens	103-117
3584469-1	1987	L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3-responsive growth hormone (GH)-secreting cell line.	Triiodothyronine	20-22	growth hormone 1	Homo sapiens	103-117
3114967-12	1987	Triiodothyronine, which induces 4"-nitrophenol-specific UDP-GT and depresses bilirubin-specific UDPG, had little effect on 4"-hydroxy-DAB UDP-GT activity.	Triiodothyronine	0-16	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	56-62
3471759-1	1987	In GC cells, a growth hormone-producing rat pituitary cell line, 3,5,3"-triiodo-L-thyronine (L-T3) rapidly stimulates the transcription rate of the growth hormone gene which parallels the level of chromatin-associated L-T3-receptor complexes (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	65-91	gonadotropin releasing hormone receptor	Rattus norvegicus	15-29
3471759-1	1987	In GC cells, a growth hormone-producing rat pituitary cell line, 3,5,3"-triiodo-L-thyronine (L-T3) rapidly stimulates the transcription rate of the growth hormone gene which parallels the level of chromatin-associated L-T3-receptor complexes (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	65-91	gonadotropin releasing hormone receptor	Rattus norvegicus	148-162
3471759-1	1987	In GC cells, a growth hormone-producing rat pituitary cell line, 3,5,3"-triiodo-L-thyronine (L-T3) rapidly stimulates the transcription rate of the growth hormone gene which parallels the level of chromatin-associated L-T3-receptor complexes (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	95-97	gonadotropin releasing hormone receptor	Rattus norvegicus	15-29
3569419-2	1987	Therefore the possible antidepressant-like activity of triiodothyroacetic acid (TA3), a natural metabolite of T3, was investigated in rats subjected to helplessness training.	Triiodothyronine	110-112	trace amine-associated receptor 9	Rattus norvegicus	80-83
2437804-3	1987	Second, 3,5,3"-triiodo-L-thyronine (T3) and epinephrine, which increased cellular cAMP concentration but had no effect on cellular cGMP concentration, increased 2-DG uptake in the rat thymocyte.	Triiodothyronine	6-34	cathelicidin antimicrobial peptide	Rattus norvegicus	82-86
2437804-3	1987	Second, 3,5,3"-triiodo-L-thyronine (T3) and epinephrine, which increased cellular cAMP concentration but had no effect on cellular cGMP concentration, increased 2-DG uptake in the rat thymocyte.	Triiodothyronine	36-38	cathelicidin antimicrobial peptide	Rattus norvegicus	82-86
3830179-11	1987	3,3",5-Triiodothyronine in its physiological concentration significantly enhances the response in glucokinase mRNA at the nuclear level, while glucocorticoids in their physiological concentration predominantly stabilize the translatable glucokinase mRNA.	Triiodothyronine	0-23	glucokinase	Rattus norvegicus	98-109
3584859-5	1987	No changes in serum liver enzymes and lipids were observed after thyroid hormone administration, whereas red blood cell glucose-6-phosphate dehydrogenase (G-6-PD) and urinary OH-proline were slightly enhanced during 120 micrograms/day L-T3 regimen.	Triiodothyronine	235-239	glucose-6-phosphate dehydrogenase	Homo sapiens	120-153
3648478-1	1987	The regulation of a gene, designated spot 14, which is rapidly induced in rat liver in response to 3,5,3"-triiodo-L-thyronine (T3) was studied as a model for exploring the molecular basis of thyroid hormone action.	Triiodothyronine	127-129	thyroid hormone responsive	Rattus norvegicus	37-44
3827920-0	1987	Triiodothyronine decreases the production of androgen binding protein by rat Sertoli cells.	Triiodothyronine	0-16	sex hormone binding globulin	Rattus norvegicus	45-69
3827920-1	1987	Triiodothyronine (T3) effects on cultured Sertoli cells from immature rats were investigated by evaluating the production of androgen binding protein (ABP) a biochemical marker of Sertoli cell function.	Triiodothyronine	0-16	sex hormone binding globulin	Rattus norvegicus	125-149
3827920-1	1987	Triiodothyronine (T3) effects on cultured Sertoli cells from immature rats were investigated by evaluating the production of androgen binding protein (ABP) a biochemical marker of Sertoli cell function.	Triiodothyronine	0-16	sex hormone binding globulin	Rattus norvegicus	151-154
3793852-14	1987	We conclude that physiologic T3 concentrations inhibit the synthesis of Fn in normal human fibroblasts.	Triiodothyronine	29-31	fibronectin 1	Homo sapiens	72-74
3567145-0	1987	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels by L-triiodothyronine.	Triiodothyronine	77-95	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	14-61
3644237-4	1987	Triiodothyronine treatment of transiently transfected GC cells had little effect on CAT activity from the hGH-1 gene hybrid but increased CAT activity from the hCS-1 gene hybrid.	Triiodothyronine	0-16	chorionic somatomammotropin hormone 1	Homo sapiens	160-165
3793852-10	1987	Addition of T3 did not affect trichloroacetic acid-precipitable 35S activity but decreased the 35S activity precipitated with anti-Fn in a dose-dependent manner.	Triiodothyronine	12-14	fibronectin 1	Homo sapiens	131-133
3805007-1	1987	The gene for S14 in the rat codes for an mRNA which in lipogenic tissues (liver, fat, mammary gland) responds both to L-triiodothyronine and a high-carbohydrate, fat-free diet.	Triiodothyronine	118-136	thyroid hormone responsive	Rattus norvegicus	13-16
3805007-6	1987	In lactating mammary gland where the S14 gene is also highly expressed and regulated by L-triiodothyronine, sites HS-1, HS-2, and HS-4 are present, but HS-3 is absent.	Triiodothyronine	88-106	thyroid hormone responsive	Rattus norvegicus	37-40
3805007-13	1987	In essence, our results show that the 5" DNA flanking region of the S14 gene contains a tissue-specific DNase I-hypersensitive site which, although not influenced by thyroid status, appears essential for the expression of S14 and its regulation by L-triiodothyronine.	Triiodothyronine	248-266	thyroid hormone responsive	Rattus norvegicus	222-225
3805007-13	1987	In essence, our results show that the 5" DNA flanking region of the S14 gene contains a tissue-specific DNase I-hypersensitive site which, although not influenced by thyroid status, appears essential for the expression of S14 and its regulation by L-triiodothyronine.	Triiodothyronine	248-266	thyroid hormone responsive	Rattus norvegicus	68-71
3805007-13	1987	In essence, our results show that the 5" DNA flanking region of the S14 gene contains a tissue-specific DNase I-hypersensitive site which, although not influenced by thyroid status, appears essential for the expression of S14 and its regulation by L-triiodothyronine.	Triiodothyronine	248-266	deoxyribonuclease 1	Rattus norvegicus	104-111
2457494-0	1987	[Determining the triiodothyronine uptake and its derivative values-T4, T3 and TBG indices-based on labeled T3 binding by a mixture of activated charcoal and cellulose].	Triiodothyronine	17-33	serpin family A member 7	Homo sapiens	78-81
3799756-1	1987	Triiodothyronine has been found to enhance gonadotropin- and insulin-stimulated morphologic luteinization and progesterone production by porcine granulosa cells in culture.	Triiodothyronine	0-16	insulin	Homo sapiens	61-68
3596465-2	1987	In hyperthyroidism, including 3,3",5-triiodothyronine (T3) toxicosis, thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) is blunted.	Triiodothyronine	30-53	thyrotropin releasing hormone	Homo sapiens	101-131
3596465-2	1987	In hyperthyroidism, including 3,3",5-triiodothyronine (T3) toxicosis, thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) is blunted.	Triiodothyronine	30-53	thyrotropin releasing hormone	Homo sapiens	133-136
3596465-2	1987	In hyperthyroidism, including 3,3",5-triiodothyronine (T3) toxicosis, thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) is blunted.	Triiodothyronine	55-57	thyrotropin releasing hormone	Homo sapiens	101-131
3481768-1	1987	We have examined the effects of triiodothyronine treatment on serum TSH and pituitary cytoplasmic TSH alpha and beta mRNA levels in the hypothyroid rat.	Triiodothyronine	32-48	glycoprotein hormones, alpha polypeptide	Homo sapiens	98-107
3596465-2	1987	In hyperthyroidism, including 3,3",5-triiodothyronine (T3) toxicosis, thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) is blunted.	Triiodothyronine	55-57	thyrotropin releasing hormone	Homo sapiens	133-136
3503503-0	1987	Effects of triiodothyronine on the development of GFAP-immunoreactivity and CAT-activity in monolayer cultures of embryonal rat forebrain cells.	Triiodothyronine	11-27	glial fibrillary acidic protein	Rattus norvegicus	50-54
2448017-2	1987	It is shown that in the sera of postnatal developing animals, between 3 and 21 days, the thyroxine (T4) and the triiodothyronine (T3) binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TBG.	Triiodothyronine	112-128	serpin family A member 7	Rattus norvegicus	258-261
2448017-2	1987	It is shown that in the sera of postnatal developing animals, between 3 and 21 days, the thyroxine (T4) and the triiodothyronine (T3) binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TBG.	Triiodothyronine	130-132	serpin family A member 7	Rattus norvegicus	258-261
3793928-1	1987	The effect of thyroxine (T4) and triiodothyronine (T3) on the expression of uncoupling protein (UCP) in rat brown adipose tissue (BAT) has been examined.	Triiodothyronine	33-49	uncoupling protein 1	Rattus norvegicus	96-99
3793928-1	1987	The effect of thyroxine (T4) and triiodothyronine (T3) on the expression of uncoupling protein (UCP) in rat brown adipose tissue (BAT) has been examined.	Triiodothyronine	51-53	uncoupling protein 1	Rattus norvegicus	96-99
2439700-8	1987	If hypothyroid media were supplemented with triiodothyronine (T3) on the eighth day in culture, the quantity of MBP mRNA in the cells was restored almost completely to the levels found in the control euthyroid cells at all ages.	Triiodothyronine	44-60	myelin basic protein	Mus musculus	112-115
2439700-8	1987	If hypothyroid media were supplemented with triiodothyronine (T3) on the eighth day in culture, the quantity of MBP mRNA in the cells was restored almost completely to the levels found in the control euthyroid cells at all ages.	Triiodothyronine	62-64	myelin basic protein	Mus musculus	112-115
3533937-3	1986	Triiodothyronine or insulin caused about a 2.5-fold increase in the relative rate of synthesis of fatty acid synthase.	Triiodothyronine	0-16	fatty acid synthase	Gallus gallus	98-117
2826889-5	1987	The hormonal regulation of h-SBP secretion by a human hepatoma cell line, H5A, showed that tri-iodothyronine was more potent than estradiol or tamoxifen, which acted as estrogen agonist, in increasing secreted h-SBP and the combined effect of both thyroid and estrogen hormones resulted in an additive stimulation of h-SBP secretion.	Triiodothyronine	91-108	selenium binding protein 1	Homo sapiens	29-32
2826889-5	1987	The hormonal regulation of h-SBP secretion by a human hepatoma cell line, H5A, showed that tri-iodothyronine was more potent than estradiol or tamoxifen, which acted as estrogen agonist, in increasing secreted h-SBP and the combined effect of both thyroid and estrogen hormones resulted in an additive stimulation of h-SBP secretion.	Triiodothyronine	91-108	selenium binding protein 1	Homo sapiens	27-32
2826889-5	1987	The hormonal regulation of h-SBP secretion by a human hepatoma cell line, H5A, showed that tri-iodothyronine was more potent than estradiol or tamoxifen, which acted as estrogen agonist, in increasing secreted h-SBP and the combined effect of both thyroid and estrogen hormones resulted in an additive stimulation of h-SBP secretion.	Triiodothyronine	91-108	selenium binding protein 1	Homo sapiens	212-215
2880307-6	1987	Triiodothyronine or T4 restitution therapy reversed the changes induced by thyroidectomy on the anterior pituitary hormones (TSH, prolactin and growth hormone) and corticosterone secretion.	Triiodothyronine	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	144-158
3096256-4	1986	Basal and protirelin stimulated triiodothyronine, prolactin, and growth hormone concentrations were also measured.	Triiodothyronine	32-48	thyrotropin releasing hormone	Homo sapiens	10-20
3815855-0	1986	Hepatic damage in the rat following administration of thyroxine or triiodothyronine, assessed by measurement of plasma glutathione S-transferase YaYa concentrations.	Triiodothyronine	67-83	hematopoietic prostaglandin D synthase	Rattus norvegicus	119-144
3815855-3	1986	Administration of triiodothyronine (T3) or thyroxine (T4) resulted in increases in plasma GST YaYa concentration and in animals given high doses of T4 plasma alanine aminotransferase activity was also elevated.	Triiodothyronine	18-34	hematopoietic prostaglandin D synthase	Rattus norvegicus	90-93
3815855-3	1986	Administration of triiodothyronine (T3) or thyroxine (T4) resulted in increases in plasma GST YaYa concentration and in animals given high doses of T4 plasma alanine aminotransferase activity was also elevated.	Triiodothyronine	36-38	hematopoietic prostaglandin D synthase	Rattus norvegicus	90-93
3533937-8	1986	Addition of triiodothyronine stimulated increases in mRNA levels comparable to increases in enzyme synthesis whether insulin was present or not.	Triiodothyronine	12-28	insulin	Gallus gallus	117-124
3533937-9	1986	Thus, triiodothyronine regulates fatty acid synthase primarily by controlling the amount of its mRNA.	Triiodothyronine	6-22	fatty acid synthase	Gallus gallus	33-52
3533937-10	1986	Addition of insulin, in the presence of triiodothyronine, stimulated enzyme synthesis by 14-fold and mRNA levels by only 2-fold.	Triiodothyronine	40-56	insulin	Gallus gallus	12-19
3533937-13	1986	After the addition of triiodothyronine, fatty acid synthase mRNA accumulated with sigmoidal kinetics, approaching a new steady state about 48 h after the addition of hormone.	Triiodothyronine	22-38	fatty acid synthase	Gallus gallus	40-59
3533937-15	1986	We suggest that the abundances of both fatty acid synthase and malic enzyme mRNAs are regulated by a common triiodothyronine-induced peptide intermediate which has a relatively long half-life.	Triiodothyronine	108-124	fatty acid synthase	Gallus gallus	39-58
3464596-1	1986	We have located sequences within the rat growth hormone (rGH) promoter region which are required for pituitary cell-type specific responsiveness to T3 (thyroid hormone, 3,5,3"-L-triiodothyronine).	Triiodothyronine	148-150	gonadotropin releasing hormone receptor	Rattus norvegicus	41-55
2428817-0	1986	The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.	Triiodothyronine	57-73	growth hormone 1	Homo sapiens	10-24
3095102-0	1986	Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.	Triiodothyronine	0-16	tyrosinase	Mus musculus	49-59
3091628-0	1986	Sustained rises in serum thyrotropin, thyroxine, and triiodothyronine during long term, continuous thyrotropin-releasing hormone treatment in patients with amyotrophic lateral sclerosis.	Triiodothyronine	53-69	thyrotropin releasing hormone	Homo sapiens	99-128
3091628-10	1986	These results provide direct evidence in man that chronic TRH administration can cause modest sustained increases in serum TSH and thyroid hormones, though the metabolic consequences of these changes are uncertain, and appears to raise the set-point of the pituitary-thyroid axis, i.e. the serum T4 and T3 concentrations needed for a given degree of suppression of basal TSH secretion.	Triiodothyronine	303-305	thyrotropin releasing hormone	Homo sapiens	58-61
3019691-5	1986	Preincubation with either T3 (0.1 microM) or dexamethasone (0.1 microM) for 4 h significantly enhanced the cAMP response on PEPck mRNA.	Triiodothyronine	26-28	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	124-129
3760185-0	1986	Opposing effects of glucagon and triiodothyronine on the hepatic levels of messenger ribonucleic acid S14 and the dependence of such effects on circadian factors.	Triiodothyronine	33-49	thyroid hormone responsive	Rattus norvegicus	102-105
3533069-4	1986	daily) plus triiodothyronine (50 micrograms) resulted in a marginal decrease (NS) in soluble glucokinase activity but significantly increased soluble hexokinase (p less than 0.05) activity.	Triiodothyronine	12-28	glucokinase	Gallus gallus	93-104
3734668-4	1986	Tri-iodothyronine treatment led to a small but significant fall in prolactin release by 72 h, but caused marked dose- and time-dependent reductions in prolactin mRNA levels at 48-72 h. Phenytoin, however, caused more rapid falls in both prolactin release and mRNA concentrations.	Triiodothyronine	0-17	prolactin	Rattus norvegicus	67-76
3015238-1	1986	The response of an established line of non-transformed adult rat liver epithelial cells (ARL 15) to thyroid hormone (T3) (3,5,3"-triiodothyronine) was characterized.	Triiodothyronine	117-119	ADP-ribosylation factor like GTPase 15	Rattus norvegicus	89-95
3015238-1	1986	The response of an established line of non-transformed adult rat liver epithelial cells (ARL 15) to thyroid hormone (T3) (3,5,3"-triiodothyronine) was characterized.	Triiodothyronine	122-145	ADP-ribosylation factor like GTPase 15	Rattus norvegicus	89-95
2424908-2	1986	We have previously shown that 3,5,3"-triiodo-L-thyronine (L-T3) stimulates cell growth and a 4- to 8-fold increase in growth hormone mRNA in GH1 cells.	Triiodothyronine	30-56	gonadotropin releasing hormone receptor	Rattus norvegicus	118-132
2424908-2	1986	We have previously shown that 3,5,3"-triiodo-L-thyronine (L-T3) stimulates cell growth and a 4- to 8-fold increase in growth hormone mRNA in GH1 cells.	Triiodothyronine	58-62	gonadotropin releasing hormone receptor	Rattus norvegicus	118-132
2876926-1	1986	Plasma concentrations of thyroxine (T4) and triiodothyronine (T3) were marginally (less than 25%) lowered 10 and 60 min, respectively, following somatostatin (SRIF) administration (at doses of 10-30 micrograms/kg) in immature domestic fowl.	Triiodothyronine	62-64	somatostatin	Homo sapiens	145-157
3734668-0	1986	Tri-iodothyronine and phenytoin reduce prolactin messenger RNA levels in cultured rat pituitary cells.	Triiodothyronine	0-17	prolactin	Rattus norvegicus	39-48
3781067-2	1986	In vitro effect of triiodothyronine (T3) on FN synthesis by cultured human fetal skin fibroblasts was also studied.	Triiodothyronine	19-35	fibronectin 1	Homo sapiens	44-46
3781067-2	1986	In vitro effect of triiodothyronine (T3) on FN synthesis by cultured human fetal skin fibroblasts was also studied.	Triiodothyronine	37-39	fibronectin 1	Homo sapiens	44-46
2874184-2	1986	Plasma thyroxine (T4) and tri-iodothyronine (T3) concentrations were markedly increased within 10 min of antisomatostatin administration and remained raised for at least 5 h. The increases in the T3 and T4 concentrations following somatostatin immunoneutralization were directly related to the volume of antisera administered.	Triiodothyronine	45-47	somatostatin	Homo sapiens	109-121
3098965-1	1986	Thyroxine (T4) and triiodothyronine (T3) injected into adult rats causes first an increase and then a decrease in lactase activity measured subsequently in intestinal homogenates of rat jejunum.	Triiodothyronine	19-35	lactase	Rattus norvegicus	114-121
3098965-1	1986	Thyroxine (T4) and triiodothyronine (T3) injected into adult rats causes first an increase and then a decrease in lactase activity measured subsequently in intestinal homogenates of rat jejunum.	Triiodothyronine	37-39	lactase	Rattus norvegicus	114-121
2426166-2	1986	After 3 days of treatment with T3 (0.5 micrograms/100 g body weight) serum TSH, alpha and TSH-beta levels were 77%, 79% and 44% of control, respectively.	Triiodothyronine	31-33	glycoprotein hormones, alpha subunit	Mus musculus	75-85
2426166-2	1986	After 3 days of treatment with T3 (0.5 micrograms/100 g body weight) serum TSH, alpha and TSH-beta levels were 77%, 79% and 44% of control, respectively.	Triiodothyronine	31-33	thyroid stimulating hormone, beta subunit	Mus musculus	90-98
3734668-4	1986	Tri-iodothyronine treatment led to a small but significant fall in prolactin release by 72 h, but caused marked dose- and time-dependent reductions in prolactin mRNA levels at 48-72 h. Phenytoin, however, caused more rapid falls in both prolactin release and mRNA concentrations.	Triiodothyronine	0-17	prolactin	Rattus norvegicus	151-160
3734668-4	1986	Tri-iodothyronine treatment led to a small but significant fall in prolactin release by 72 h, but caused marked dose- and time-dependent reductions in prolactin mRNA levels at 48-72 h. Phenytoin, however, caused more rapid falls in both prolactin release and mRNA concentrations.	Triiodothyronine	0-17	prolactin	Rattus norvegicus	151-160
3754508-1	1986	The messenger RNA (mRNA) coding for the rat hepatic protein spot 14(S14) (mol wt 17,000; pI 4.9) is rapidly responsive to T3 and carbohydrate administration in the adult animal.	Triiodothyronine	122-124	thyroid hormone responsive	Rattus norvegicus	68-71
3521603-1	1986	In hypophysectomized--diabetic rats full restoration of hepatic HMG-CoA reductase activity required administration of both triiodothyronine and insulin.	Triiodothyronine	123-139	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	64-81
3090567-4	1986	TRH administration increased circulating T3 levels in sham-operated animals, but had no effects in either hypo- or hyperthyroid, thyroidectomized rats.	Triiodothyronine	41-43	thyrotropin releasing hormone	Rattus norvegicus	0-3
2939837-4	1986	Triiodothyronine reduced alcohol dehydrogenase activity of cultured hepatocytes from male and hypothyroid female rats in a dose-dependent fashion, confirming that thyroid hormone had pituitary-independent effects on the enzyme activity.	Triiodothyronine	0-16	aldo-keto reductase family 1 member A1	Rattus norvegicus	25-46
2869786-0	1986	Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin.	Triiodothyronine	65-81	serpin family A member 7	Homo sapiens	91-117
3755115-5	1986	Positive correlation was obtained between Fn levels and serum levels of triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	72-88	fibronectin 1	Homo sapiens	42-44
3755115-5	1986	Positive correlation was obtained between Fn levels and serum levels of triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	90-92	fibronectin 1	Homo sapiens	42-44
2869786-3	1986	At molar ratios of oleic acid to thyroxine-binding globulin of 1000:1, 2000:1 and 4000:1, the degree of inhibition of triiodothyronine binding was 24%, 41% and 76%, respectively.	Triiodothyronine	118-134	serpin family A member 7	Homo sapiens	33-59
3948788-0	1986	Steroids and triiodothyronine reduce nerve growth factor concentrations in medium conditioned by L-929 fibroblasts.	Triiodothyronine	13-29	nerve growth factor	Mus musculus	37-56
3083737-1	1986	The effect of thyrotropin-releasing hormone (TRH) on equine thyroid function was determined by quantifying serum thyroxine (T4) and 3,5,3"-triiodothyronine (T3) before and after TRH administration.	Triiodothyronine	132-155	thyrotropin releasing hormone	Equus caballus	45-48
3082532-7	1986	Apparently, the distribution of thyroxin and triiodothyronine among the binding sites on TBG changes with variations in TBG concentration.	Triiodothyronine	45-61	serpin family A member 7	Homo sapiens	89-92
3082532-7	1986	Apparently, the distribution of thyroxin and triiodothyronine among the binding sites on TBG changes with variations in TBG concentration.	Triiodothyronine	45-61	serpin family A member 7	Homo sapiens	120-123
3948790-0	1986	Insulin-like growth factor-I action on hypothyroid rat pituitary cells: suppression of triiodothyronine-induced growth hormone secretion and messenger ribonucleic acid levels.	Triiodothyronine	87-103	insulin-like growth factor 1	Rattus norvegicus	0-28
3948790-0	1986	Insulin-like growth factor-I action on hypothyroid rat pituitary cells: suppression of triiodothyronine-induced growth hormone secretion and messenger ribonucleic acid levels.	Triiodothyronine	87-103	gonadotropin releasing hormone receptor	Rattus norvegicus	112-126
3487684-7	1986	After hormonal stimulation for 1 week with either tri-iodothyronine (T3) or dihydrotestosterone (DHT), EGF protein concentration in the glands was induced to the same level at both ages.	Triiodothyronine	50-67	epidermal growth factor	Mus musculus	103-106
3487684-7	1986	After hormonal stimulation for 1 week with either tri-iodothyronine (T3) or dihydrotestosterone (DHT), EGF protein concentration in the glands was induced to the same level at both ages.	Triiodothyronine	69-71	epidermal growth factor	Mus musculus	103-106
3486241-3	1986	With concentrations which stimulated growth, EGF was found to inhibit human thyroid cell function as measured by the release of radioimmunoassayable tri-iodothyronine into the incubation medium.	Triiodothyronine	149-166	epidermal growth factor	Homo sapiens	45-48
3081281-1	1986	We determined binding characteristics of the triiodothyronine (T3) analog tracer used in the Amerlex and Amerlex-M FT3 radioimmunoassay for the three endogenous binding proteins in serum: thyroxin-binding globulin (TBG), thyroxin binding prealbumin (PA), and albumin.	Triiodothyronine	45-61	serpin family A member 7	Homo sapiens	188-213
3081281-1	1986	We determined binding characteristics of the triiodothyronine (T3) analog tracer used in the Amerlex and Amerlex-M FT3 radioimmunoassay for the three endogenous binding proteins in serum: thyroxin-binding globulin (TBG), thyroxin binding prealbumin (PA), and albumin.	Triiodothyronine	63-65	serpin family A member 7	Homo sapiens	188-213
2422035-5	1986	Adrenaline, triiodothyronine, estradiol and progesterone were tested for their ability to stimulate alpha 2-macroglobulin synthesis.	Triiodothyronine	12-28	alpha-2-macroglobulin	Homo sapiens	100-121
2422035-6	1986	Only triiodothyronine induced alpha 2-macroglobulin synthesis markedly.	Triiodothyronine	5-21	alpha-2-macroglobulin	Rattus norvegicus	30-51
2422035-8	1986	Besides glucocorticoids and triiodothyronine a non-dialyzable factor (HSF) derived from rat Kupffer cells or human peripheral blood monocytes was found to be able to stimulate alpha 2-macroglobulin synthesis in hepatocytes.	Triiodothyronine	28-44	interleukin 6	Homo sapiens	70-73
2422035-8	1986	Besides glucocorticoids and triiodothyronine a non-dialyzable factor (HSF) derived from rat Kupffer cells or human peripheral blood monocytes was found to be able to stimulate alpha 2-macroglobulin synthesis in hepatocytes.	Triiodothyronine	28-44	alpha-2-macroglobulin	Homo sapiens	176-197
3511056-13	1986	Glucocorticoids and other hormones (e.g. triiodothyronine) are also essential for maximum induction of SCP but play permissive roles.	Triiodothyronine	41-57	fatty acid binding protein 1	Rattus norvegicus	103-106
3953234-0	1986	Triiodothyronine increases responsiveness of cultured rat bone cells to parathyroid hormone.	Triiodothyronine	0-16	parathyroid hormone	Rattus norvegicus	72-91
3953234-1	1986	Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication.	Triiodothyronine	208-224	ornithine decarboxylase 1	Rattus norvegicus	142-145
3953234-1	1986	Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication.	Triiodothyronine	208-224	parathyroid hormone	Rattus norvegicus	173-192
3953234-1	1986	Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication.	Triiodothyronine	208-224	ornithine decarboxylase 1	Rattus norvegicus	240-243
3953234-1	1986	Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication.	Triiodothyronine	226-228	ornithine decarboxylase 1	Rattus norvegicus	142-145
3953234-1	1986	Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication.	Triiodothyronine	226-228	parathyroid hormone	Rattus norvegicus	173-192
2422102-1	1986	We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase (HL) activity from cultured rat hepatocytes.	Triiodothyronine	36-52	lipase C, hepatic type	Rattus norvegicus	114-128
2422102-1	1986	We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase (HL) activity from cultured rat hepatocytes.	Triiodothyronine	54-56	lipase C, hepatic type	Rattus norvegicus	114-128
2422102-1	1986	We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase (HL) activity from cultured rat hepatocytes.	Triiodothyronine	54-56	lipase C, hepatic type	Rattus norvegicus	130-132
3949283-4	1986	Significantly high positive correlation was found between erythrocytes catalase activity and the levels of thyroxine (r = 0.5794, n = 36, P less than 0.001), and slight positive correlation was detected between catalase activity and the levels of triiodothyronine (r = 0.3978, n = 33, P less than 0.05).	Triiodothyronine	247-263	catalase	Homo sapiens	211-219
3085079-3	1986	Treatment with triiodothyronine (T3) but not thyroxine (T4) (at 1 ppm in the diet from hatch) consistently and significantly reduced the growth rate and decreased the plasma concentrations of GH following TRH injection in normal (DwDw males or Dw-females), hemizygous dwarf (dw-) female, and heterozygous (Dwdw) male lines of broiler chickens.	Triiodothyronine	15-31	growth hormone	Gallus gallus	192-194
3085079-3	1986	Treatment with triiodothyronine (T3) but not thyroxine (T4) (at 1 ppm in the diet from hatch) consistently and significantly reduced the growth rate and decreased the plasma concentrations of GH following TRH injection in normal (DwDw males or Dw-females), hemizygous dwarf (dw-) female, and heterozygous (Dwdw) male lines of broiler chickens.	Triiodothyronine	15-31	thyrotropin releasing hormone	Gallus gallus	205-208
3085079-3	1986	Treatment with triiodothyronine (T3) but not thyroxine (T4) (at 1 ppm in the diet from hatch) consistently and significantly reduced the growth rate and decreased the plasma concentrations of GH following TRH injection in normal (DwDw males or Dw-females), hemizygous dwarf (dw-) female, and heterozygous (Dwdw) male lines of broiler chickens.	Triiodothyronine	33-35	growth hormone	Gallus gallus	192-194
3085079-3	1986	Treatment with triiodothyronine (T3) but not thyroxine (T4) (at 1 ppm in the diet from hatch) consistently and significantly reduced the growth rate and decreased the plasma concentrations of GH following TRH injection in normal (DwDw males or Dw-females), hemizygous dwarf (dw-) female, and heterozygous (Dwdw) male lines of broiler chickens.	Triiodothyronine	33-35	thyrotropin releasing hormone	Gallus gallus	205-208
3096042-3	1986	GH depresses the secretion of thyrotropin and the thyroid hormones and increases the peripheral conversion of thyroxine to triiodothyronine.	Triiodothyronine	123-139	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
3541753-1	1986	The levels of malic enzyme and fatty acid synthase are increased by feeding and decreased by starvation in liver in vivo and are increased by triiodothyronine and decreased by glucagon in hepatocytes in culture.	Triiodothyronine	142-158	fatty acid synthase	Gallus gallus	31-50
3541753-6	1986	In chick-embryo hepatocytes incubated in serum-free medium containing insulin, triiodothyronine causes a greater than 10-fold increase in levels of both malic enzyme and fatty acid synthase mRNAs.	Triiodothyronine	79-95	insulin	Gallus gallus	70-77
3541753-6	1986	In chick-embryo hepatocytes incubated in serum-free medium containing insulin, triiodothyronine causes a greater than 10-fold increase in levels of both malic enzyme and fatty acid synthase mRNAs.	Triiodothyronine	79-95	fatty acid synthase	Gallus gallus	170-189
3541753-7	1986	Kinetic and inhibitor experiments suggest a protein intermediate in the increases of malic enzyme and fatty acid synthase mRNAs caused by triiodothyronine.	Triiodothyronine	138-154	fatty acid synthase	Gallus gallus	102-121
3792055-3	1986	However, simultaneous injections of triiodothyronine (T3), in the physiological range, and hyperdynamic doses of oestrogenic substances (Ayerst Co., mainly oestrone) into OS chickens resulted in serum levels of VLDL and vitellogenins which were more than double those achieved without thyroid hormone treatment.	Triiodothyronine	36-52	very low density lipoprotein receptor	Gallus gallus	211-215
3792055-3	1986	However, simultaneous injections of triiodothyronine (T3), in the physiological range, and hyperdynamic doses of oestrogenic substances (Ayerst Co., mainly oestrone) into OS chickens resulted in serum levels of VLDL and vitellogenins which were more than double those achieved without thyroid hormone treatment.	Triiodothyronine	54-56	very low density lipoprotein receptor	Gallus gallus	211-215
2876108-6	1986	Thyroid hormone (T3) has been shown to stimulate MBP methyltransferase [Amur et al, 1984] and could exert its stimulatory effect through beta-adrenergic-dependent systems.	Triiodothyronine	17-19	myelin basic protein	Mus musculus	49-52
3455610-1	1986	The concentrations of the general neuronal markers D2-protein (N-CAM), D3-protein and neuron specific enolase (NSE) in reaggregating cultures of fetal rat telencephalon cells were affected by the presence of 30 nM triiodothyronine in the defined culture medium.	Triiodothyronine	214-230	enolase 2	Rattus norvegicus	86-109
3455610-5	1986	However, as shown previously both triiodothyronine and NGF increased the activity of choline acetyltransferase, a marker for cholinergic neurons.	Triiodothyronine	34-50	choline O-acetyltransferase	Rattus norvegicus	85-110
3080544-1	1986	The effect of thyrotrophin-releasing hormone (TRH) on the circulating plasma levels of tri-iodothyronine (T3) and thyroxine (T4) was determined in the same group of animals (four cattle and four Murrah buffaloes) during hot dry (HD), hot humid (HH) and cold environmental conditions.	Triiodothyronine	87-104	thyrotropin releasing hormone	Bos taurus	14-44
3080544-1	1986	The effect of thyrotrophin-releasing hormone (TRH) on the circulating plasma levels of tri-iodothyronine (T3) and thyroxine (T4) was determined in the same group of animals (four cattle and four Murrah buffaloes) during hot dry (HD), hot humid (HH) and cold environmental conditions.	Triiodothyronine	87-104	thyrotropin releasing hormone	Bos taurus	46-49
3938790-4	1985	In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses.	Triiodothyronine	193-197	thyroid stimulating hormone subunit beta	Homo sapiens	47-55
4077981-1	1985	Previous reports suggest that a type II iodothyronine 5"-deiodinase may become the main enzymatic pathway for extrathyroidal triiodothyronine (T3) generation when the enzyme levels are sufficiently elevated and/or liver and kidney type I 5"-deiodinase activity is depressed.	Triiodothyronine	125-141	iodothyronine deiodinase 1	Rattus norvegicus	231-251
4077981-1	1985	Previous reports suggest that a type II iodothyronine 5"-deiodinase may become the main enzymatic pathway for extrathyroidal triiodothyronine (T3) generation when the enzyme levels are sufficiently elevated and/or liver and kidney type I 5"-deiodinase activity is depressed.	Triiodothyronine	143-145	iodothyronine deiodinase 1	Rattus norvegicus	231-251
3009989-5	1986	A combined incubation with estradiol (100 nM) and triiodothyronine (10 nM) increased SBP-like protein secretion more than estradiol (1 microM) alone.	Triiodothyronine	50-66	selenium binding protein 1	Homo sapiens	85-88
3005082-0	1986	Stereospecific transport of triiodothyronine to cytoplasm and nucleus in GH1 cells.	Triiodothyronine	28-44	growth hormone 1	Rattus norvegicus	73-76
3938790-4	1985	In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses.	Triiodothyronine	128-132	glycoprotein hormones, alpha polypeptide	Homo sapiens	31-41
3938790-4	1985	In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses.	Triiodothyronine	128-132	thyroid stimulating hormone subunit beta	Homo sapiens	47-55
4055787-0	1985	Regulation of growth hormone mRNA synthesis by 3,5,3"-triiodo-L-thyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells).	Triiodothyronine	47-73	gonadotropin releasing hormone receptor	Rattus norvegicus	14-28
3938790-4	1985	In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses.	Triiodothyronine	193-197	thyroid stimulating hormone subunit beta	Homo sapiens	47-55
2867482-4	1985	Treatment of TPTX rats with small doses of triiodothyronine (T3) restored an episodic pattern of GH secretion, but with lower peak values than controls, as well as the GH response to clonidine.	Triiodothyronine	43-59	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
2867482-4	1985	Treatment of TPTX rats with small doses of triiodothyronine (T3) restored an episodic pattern of GH secretion, but with lower peak values than controls, as well as the GH response to clonidine.	Triiodothyronine	43-59	gonadotropin releasing hormone receptor	Rattus norvegicus	168-170
2867482-4	1985	Treatment of TPTX rats with small doses of triiodothyronine (T3) restored an episodic pattern of GH secretion, but with lower peak values than controls, as well as the GH response to clonidine.	Triiodothyronine	61-63	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
4094520-7	1985	Triiodothyronine (T3) treatment of the hypothyroid rat (25 micrograms/100 g body weight/day for four days) corrected phospholipase A2 and lysophospholipase activities to the level of the control rat, but failed to correct the increased mitochondrial GPAT activity and not only corrected but lowered GPCAT activity to the level of the hyperthyroid rat.	Triiodothyronine	0-16	phospholipase A2 group IB	Rattus norvegicus	117-155
4094520-7	1985	Triiodothyronine (T3) treatment of the hypothyroid rat (25 micrograms/100 g body weight/day for four days) corrected phospholipase A2 and lysophospholipase activities to the level of the control rat, but failed to correct the increased mitochondrial GPAT activity and not only corrected but lowered GPCAT activity to the level of the hyperthyroid rat.	Triiodothyronine	0-16	glycerol-3-phosphate acyltransferase, mitochondrial	Rattus norvegicus	250-254
4094520-7	1985	Triiodothyronine (T3) treatment of the hypothyroid rat (25 micrograms/100 g body weight/day for four days) corrected phospholipase A2 and lysophospholipase activities to the level of the control rat, but failed to correct the increased mitochondrial GPAT activity and not only corrected but lowered GPCAT activity to the level of the hyperthyroid rat.	Triiodothyronine	18-20	phospholipase A2 group IB	Rattus norvegicus	117-155
4094520-7	1985	Triiodothyronine (T3) treatment of the hypothyroid rat (25 micrograms/100 g body weight/day for four days) corrected phospholipase A2 and lysophospholipase activities to the level of the control rat, but failed to correct the increased mitochondrial GPAT activity and not only corrected but lowered GPCAT activity to the level of the hyperthyroid rat.	Triiodothyronine	18-20	glycerol-3-phosphate acyltransferase, mitochondrial	Rattus norvegicus	250-254
4055787-0	1985	Regulation of growth hormone mRNA synthesis by 3,5,3"-triiodo-L-thyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells).	Triiodothyronine	47-73	gonadotropin releasing hormone receptor	Rattus norvegicus	86-100
4074336-3	1985	This effect on histidase is reversed by the exogenous administration of tri-iodothyronine, but not by ectopic pituitary glands or purified pituitary hormones.	Triiodothyronine	72-89	histidine ammonia lyase	Rattus norvegicus	15-24
2995348-1	1985	Thyroid hormone has been shown to rapidly stimulate the rate of rat growth hormone gene transcription which parallels the kinetics of binding of 3,5,3"-triiodo-L-thyronine (L-T3) to its nuclear receptor (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	145-171	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
3934026-2	1985	Starvation delayed, but did not suppress, the triiodothyronine (T3) response to intravenously administered thyrotropin-releasing hormone (10 micrograms/kg).	Triiodothyronine	64-66	thyrotropin releasing hormone	Homo sapiens	107-136
4034528-7	1985	Correlations computed from the residual variance showed a positive relationship between percentage body protein, serum albumin, and triiodothyronine while percentage body fat was not correlated with any of the other traits.	Triiodothyronine	132-148	albumin	Sus scrofa	113-126
2995348-1	1985	Thyroid hormone has been shown to rapidly stimulate the rate of rat growth hormone gene transcription which parallels the kinetics of binding of 3,5,3"-triiodo-L-thyronine (L-T3) to its nuclear receptor (Yaffe, B. M., and Samuels, H. H. (1984) J. Biol.	Triiodothyronine	173-177	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
3900266-7	1985	The inclusion of tri-iodothyronine and raised concentrations of cortisol in culture media have been shown to modulate alpha-lactalbumin synthesis in eutherian mammals but were without effect in the tammar.	Triiodothyronine	17-34	lactalbumin alpha	Bos taurus	118-135
3904727-1	1985	Treatment of rat hepatoma cells with insulin, glucagon, thyroxine (T4) and triiodothyronine (T3) caused a concentration-dependent decrease in the monomeric actin content as measured by the deoxyribonuclease-I inhibition assay.	Triiodothyronine	75-91	insulin	Homo sapiens	37-44
3904727-1	1985	Treatment of rat hepatoma cells with insulin, glucagon, thyroxine (T4) and triiodothyronine (T3) caused a concentration-dependent decrease in the monomeric actin content as measured by the deoxyribonuclease-I inhibition assay.	Triiodothyronine	93-95	insulin	Homo sapiens	37-44
3936697-1	1985	Thyroid-stimulating hormone (TSH) and triiodothyronine (T3) responses to thyrotropin-releasing hormone (TRH) were compared in sixty depressed adolescents and sixty normal controls.	Triiodothyronine	38-54	thyrotropin releasing hormone	Homo sapiens	104-107
2411914-1	1985	Mechanisms underlying thyroid hormone-induced changes in myocardial contractile state were investigated by studying the effects of triiodothyronine (T3) on Ca2+ fluxes across the sarcolemmal membrane and Ca2+ handling by the sarcoplasmic reticulum, using spontaneously contracting monolayers of cultured chick embryo ventricular cells.	Triiodothyronine	149-151	parathyroid hormone	Gallus gallus	22-37
3926229-4	1985	In three of these patients in whom standard doses of replacement therapy were associated with a raised free thyroxine (T4) concentration but normal total and free triiodothyronine (T3) values glutathione S-transferase was increased.	Triiodothyronine	163-179	glutathione S-transferase kappa 1	Homo sapiens	192-217
3926229-4	1985	In three of these patients in whom standard doses of replacement therapy were associated with a raised free thyroxine (T4) concentration but normal total and free triiodothyronine (T3) values glutathione S-transferase was increased.	Triiodothyronine	181-183	glutathione S-transferase kappa 1	Homo sapiens	192-217
3893986-0	1985	Insulin suppresses triiodothyronine-induced growth hormone secretion by GH3 rat pituitary cells.	Triiodothyronine	19-35	insulin	Homo sapiens	0-7
3893986-7	1985	This suppression was maximal with 3.5 nM insulin and occurred after a lag period of 48 h. The previously described 20-fold synergistic stimulation of GH by T3 (0.5 nM) together with HCT (1 microM) was also suppressed by insulin (3.5 nM) by 80% during 72 h of incubation.	Triiodothyronine	156-158	insulin	Homo sapiens	41-48
3893986-7	1985	This suppression was maximal with 3.5 nM insulin and occurred after a lag period of 48 h. The previously described 20-fold synergistic stimulation of GH by T3 (0.5 nM) together with HCT (1 microM) was also suppressed by insulin (3.5 nM) by 80% during 72 h of incubation.	Triiodothyronine	156-158	insulin	Homo sapiens	220-227
3893986-11	1985	Alternatively, the inhibitory effects of insulin on T3-induced GH secretion in these cells may be posttranscriptional.	Triiodothyronine	52-54	insulin	Homo sapiens	41-48
3160351-0	1985	Effect of triiodothyronine on alcohol dehydrogenase and aldehyde dehydrogenase activities in rat liver.	Triiodothyronine	10-26	aldo-keto reductase family 1 member A1	Rattus norvegicus	30-51
4042813-3	1985	Treatment of animals carrying tumor IAK 109D with 3,5,3"-triiodo-L-thyronine (T3) (5 micrograms/100 g body weight) for 2 hr reduced TSH-beta gene transcription to less than 10% of control levels, whereas alpha RNA synthesis was reduced to 59% of control.	Triiodothyronine	50-76	aurora kinase A	Mus musculus	36-39
4042813-3	1985	Treatment of animals carrying tumor IAK 109D with 3,5,3"-triiodo-L-thyronine (T3) (5 micrograms/100 g body weight) for 2 hr reduced TSH-beta gene transcription to less than 10% of control levels, whereas alpha RNA synthesis was reduced to 59% of control.	Triiodothyronine	50-76	thyroid stimulating hormone, beta subunit	Mus musculus	132-140
4042813-3	1985	Treatment of animals carrying tumor IAK 109D with 3,5,3"-triiodo-L-thyronine (T3) (5 micrograms/100 g body weight) for 2 hr reduced TSH-beta gene transcription to less than 10% of control levels, whereas alpha RNA synthesis was reduced to 59% of control.	Triiodothyronine	78-80	aurora kinase A	Mus musculus	36-39
4042813-3	1985	Treatment of animals carrying tumor IAK 109D with 3,5,3"-triiodo-L-thyronine (T3) (5 micrograms/100 g body weight) for 2 hr reduced TSH-beta gene transcription to less than 10% of control levels, whereas alpha RNA synthesis was reduced to 59% of control.	Triiodothyronine	78-80	thyroid stimulating hormone, beta subunit	Mus musculus	132-140
2862964-0	1985	Triiodothyronine increases glutamine synthetase activity in primary cultures of rat cerebellum.	Triiodothyronine	0-16	glutamate-ammonia ligase	Rattus norvegicus	27-47
2862964-2	1985	After 7, 14 and 21 days in vitro, triiodothyronine (60 nM) was added to a set of dishes and glutamine synthetase activity was measured after 24, 48, and 72 h in both control and triiodothyronine-treated cultures.	Triiodothyronine	178-194	glutamate-ammonia ligase	Rattus norvegicus	92-112
2862964-4	1985	Triiodothyronine produced significant increases of glutamine synthetase activity after 72 h in 7-day-old cultures (+ 16%), after 48 h in 14-day-old cultures (+ 45%) and after 24 h in 21-day-old cultures (+ 27%).	Triiodothyronine	0-16	glutamate-ammonia ligase	Rattus norvegicus	51-71
3872441-0	1985	Epidermal growth factor binding to neonatal mouse skin explants and membrane preparations--effect of triiodothyronine.	Triiodothyronine	101-117	epidermal growth factor	Mus musculus	0-23
3927182-0	1985	Comparison of the ability of thyroxine and triiodothyronine to suppress TRH-induced TSH secretion by perfused rat anterior pituitary fragments.	Triiodothyronine	43-59	thyrotropin releasing hormone	Rattus norvegicus	72-75
2989614-2	1985	A significant elevation of ACE levels and a positive correlation between ACE, thyroxine, and triiodothyronine levels was found in both groups of thyrotoxicosis.	Triiodothyronine	93-109	angiotensin I converting enzyme	Homo sapiens	73-76
4011401-3	1985	The activity of citrate synthase and the capacity to oxidize pyruvate plus malate decreased rapidly after discontinuing T3 administration, reaching values below those of base line controls in 14 days, but were not different than controls at 21 days.	Triiodothyronine	120-122	citrate synthase	Rattus norvegicus	16-32
3971931-0	1985	Regulation of rat cerebrocortical and adenohypophyseal type II 5"-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine.	Triiodothyronine	91-107	iodothyronine deiodinase 2	Rattus norvegicus	55-76
3971931-0	1985	Regulation of rat cerebrocortical and adenohypophyseal type II 5"-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine.	Triiodothyronine	121-137	iodothyronine deiodinase 2	Rattus norvegicus	55-76
2982308-7	1985	Sequential analyses of mRNA activity profiles have identified an mRNA sequence (mRNAs14) coding for a protein (S14) with Mr 17 010 and pI 4.9 which responds to triiodothyronine with a lag time of less than 20 minutes.	Triiodothyronine	160-176	thyroid hormone responsive	Homo sapiens	111-114
2982308-8	1985	The coordinate regulation of mRNAs14 by carbohydrate and triiodothyronine and its presence in lipogenic tissues (fat, liver, lactating mammary tissue) suggests that S14 is involved in some aspect of fatty acid synthesis degradation or storage.	Triiodothyronine	57-73	thyroid hormone responsive	Homo sapiens	165-168
3973528-2	1985	An injection of 1 and 10 micrograms ovine prolactin into 18-day-old chick embryos increased serum concentrations of tri-iodothyronine (T3) five- and eightfold respectively after 2 h. At the same time serum concentrations of thyroxine (T4) and reverse T3 (rT3) were decreased in the chick embryo, but only with 10 micrograms prolactin.	Triiodothyronine	116-133	prolactin	Gallus gallus	42-51
3973528-2	1985	An injection of 1 and 10 micrograms ovine prolactin into 18-day-old chick embryos increased serum concentrations of tri-iodothyronine (T3) five- and eightfold respectively after 2 h. At the same time serum concentrations of thyroxine (T4) and reverse T3 (rT3) were decreased in the chick embryo, but only with 10 micrograms prolactin.	Triiodothyronine	135-137	prolactin	Gallus gallus	42-51
3872441-1	1985	Daily treatment of newborn Swiss-Webster mice with triiodothyronine (T3, 500 ng/day) increased epidermal growth factor (EGF) content in whole skin (epidermis + dermis).	Triiodothyronine	51-67	epidermal growth factor	Mus musculus	95-118
3872441-1	1985	Daily treatment of newborn Swiss-Webster mice with triiodothyronine (T3, 500 ng/day) increased epidermal growth factor (EGF) content in whole skin (epidermis + dermis).	Triiodothyronine	51-67	epidermal growth factor	Mus musculus	120-123
3872441-1	1985	Daily treatment of newborn Swiss-Webster mice with triiodothyronine (T3, 500 ng/day) increased epidermal growth factor (EGF) content in whole skin (epidermis + dermis).	Triiodothyronine	69-71	epidermal growth factor	Mus musculus	95-118
3872441-1	1985	Daily treatment of newborn Swiss-Webster mice with triiodothyronine (T3, 500 ng/day) increased epidermal growth factor (EGF) content in whole skin (epidermis + dermis).	Triiodothyronine	69-71	epidermal growth factor	Mus musculus	120-123
3882253-8	1985	Binding of complex of triiodothyronine-bovine serum albumin--gold on the cytoplasmic membrane of LEP cells in a short term tissue culture showed a possibility of tracing non-peptidic hormones binding on specific receptors.	Triiodothyronine	22-38	leptin S homeolog	Xenopus laevis	97-100
3977836-5	1985	Both cold acclimation and tri-iodothyronine (30 micrograms/day per kg) decreased hepatic delta 6-desaturase activity of obese mice to levels observed in lean mice, whereas the increase in activity in obese mice was still maintained after the induction of hypothyroidism.	Triiodothyronine	26-43	fatty acid desaturase 2	Mus musculus	89-107
3981636-0	1985	Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine.	Triiodothyronine	74-90	gonadotropin releasing hormone receptor	Rattus norvegicus	14-28
3981636-2	1985	We have characterized the process by which the growth hormone (GH) gene is stimulated in rat pituitary tumor cells (GC or GH3) by the steroid hormone dexamethasone (Dex) and the thyroid hormone, L-triiodothyronine (T3).	Triiodothyronine	195-213	gonadotropin releasing hormone receptor	Rattus norvegicus	47-61
3981636-2	1985	We have characterized the process by which the growth hormone (GH) gene is stimulated in rat pituitary tumor cells (GC or GH3) by the steroid hormone dexamethasone (Dex) and the thyroid hormone, L-triiodothyronine (T3).	Triiodothyronine	195-213	gonadotropin releasing hormone receptor	Rattus norvegicus	63-65
3981636-2	1985	We have characterized the process by which the growth hormone (GH) gene is stimulated in rat pituitary tumor cells (GC or GH3) by the steroid hormone dexamethasone (Dex) and the thyroid hormone, L-triiodothyronine (T3).	Triiodothyronine	215-217	gonadotropin releasing hormone receptor	Rattus norvegicus	47-61
3981636-2	1985	We have characterized the process by which the growth hormone (GH) gene is stimulated in rat pituitary tumor cells (GC or GH3) by the steroid hormone dexamethasone (Dex) and the thyroid hormone, L-triiodothyronine (T3).	Triiodothyronine	215-217	gonadotropin releasing hormone receptor	Rattus norvegicus	63-65
3981636-4	1985	A fivefold transcriptional stimulation of GH nuclear RNA occurs in cells cultured with serum substitute medium and induced with Dex + T3, while T3 alone induces a modest two- to threefold stimulation.	Triiodothyronine	134-136	gonadotropin releasing hormone receptor	Rattus norvegicus	42-44
3932176-8	1985	When tumor cells were pretreated with various concentrations of triiodothyronine (T3), the PRL release was inhibited by 50% with 5 X 10(-11) M T3 and by 80% with 10(-9) M T3.	Triiodothyronine	64-80	prolactin	Homo sapiens	91-94
2981760-0	1985	Triiodothyronine increases serum angiotensin converting enzyme.	Triiodothyronine	0-16	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	33-62
3932176-8	1985	When tumor cells were pretreated with various concentrations of triiodothyronine (T3), the PRL release was inhibited by 50% with 5 X 10(-11) M T3 and by 80% with 10(-9) M T3.	Triiodothyronine	82-84	prolactin	Homo sapiens	91-94
2981760-2	1985	Serum angiotensin converting enzyme was significantly increased in all animals given triiodothyronine compared to controls.	Triiodothyronine	85-101	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	6-35
3932176-8	1985	When tumor cells were pretreated with various concentrations of triiodothyronine (T3), the PRL release was inhibited by 50% with 5 X 10(-11) M T3 and by 80% with 10(-9) M T3.	Triiodothyronine	143-145	prolactin	Homo sapiens	91-94
3932176-8	1985	When tumor cells were pretreated with various concentrations of triiodothyronine (T3), the PRL release was inhibited by 50% with 5 X 10(-11) M T3 and by 80% with 10(-9) M T3.	Triiodothyronine	143-145	prolactin	Homo sapiens	91-94
2981377-5	1985	The normal suppression of basal and TRH-stimulated thyrotropin increase after administration of triiodothyronine did not occur.	Triiodothyronine	96-112	thyrotropin releasing hormone	Homo sapiens	36-39
6085309-1	1984	In vivo treatment of rats with triiodothyronine (0.3 micrograms per g body wt for four consecutive days) increases both poly (ADP-ribose) polymerase activity and DNA synthesis in myocardial nuclei obtained from 18-21-days-old rats.	Triiodothyronine	31-47	poly (ADP-ribose) polymerase 1	Rattus norvegicus	120-148
3886987-4	1985	Plasma levels of insulin and triiodothyronine were decreased before the elevation of basal DNA synthesis in CCl4-treated rats.	Triiodothyronine	29-45	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
6085309-3	1984	A correlation was observed between the degree of inhibition of poly(ADP-ribose) polymerase and ventricular enlargement in triiodothyronine treated animals.	Triiodothyronine	122-138	poly (ADP-ribose) polymerase 1	Rattus norvegicus	63-90
6592596-8	1984	On the contrary, a dramatic decrease in thyroglobulin gene transcription was observed in those animals in which endogenous rTSH levels had been suppressed by hypophysectomy or by the administration of triiodothyronine.	Triiodothyronine	201-217	thyroglobulin	Rattus norvegicus	40-53
6480809-10	1984	Pharmacological studies of TSH, TSH-alpha, and PRL release using thyroid hormones (T3), dopamine agonist (bromocriptine), TRH, and cholera toxin yielded the following results: 1) T3 after 3 days of incubation produced a dose-dependent inhibition of TSH, TSH-alpha, and PRL release.	Triiodothyronine	83-85	prolactin	Homo sapiens	47-50
6092333-1	1984	The temporal relationship between the occupancy of the thyroid hormone (3,5,3"-triiodo-L-thyronine (T3)) and glucocorticoid (dexamethasone) receptors and the rate of growth hormone (GH) gene transcription and mRNA accumulation were investigated.	Triiodothyronine	72-98	gonadotropin releasing hormone receptor	Rattus norvegicus	166-180
6092333-1	1984	The temporal relationship between the occupancy of the thyroid hormone (3,5,3"-triiodo-L-thyronine (T3)) and glucocorticoid (dexamethasone) receptors and the rate of growth hormone (GH) gene transcription and mRNA accumulation were investigated.	Triiodothyronine	72-98	gonadotropin releasing hormone receptor	Rattus norvegicus	182-184
12266542-5	1984	Increased serum TBG concentrations result in a new thyroid hormone equilibrium characterized by an elevated serum thyroxine (T4) level and a reduced resin triiodothyronine (T3 uptake) level but a persistently normal serum-free T4 (FT4) level if the patient is euthyroid.	Triiodothyronine	155-171	serpin family A member 7	Homo sapiens	16-19
12266542-5	1984	Increased serum TBG concentrations result in a new thyroid hormone equilibrium characterized by an elevated serum thyroxine (T4) level and a reduced resin triiodothyronine (T3 uptake) level but a persistently normal serum-free T4 (FT4) level if the patient is euthyroid.	Triiodothyronine	173-175	serpin family A member 7	Homo sapiens	16-19
6483867-0	1984	Thyroxine and triiodothyronine in milk of cows, goats, sheep, and guinea pigs.	Triiodothyronine	14-30	Weaning weight-maternal milk	Bos taurus	34-38
6509376-5	1984	In hypothyroid rat cerebellum, a single injection of triiodothyronine (T3, 100 micrograms/100 g 18 h before sacrifice) increased significantly ODC activity at all ages.	Triiodothyronine	53-69	ornithine decarboxylase 1	Rattus norvegicus	143-146
6509376-5	1984	In hypothyroid rat cerebellum, a single injection of triiodothyronine (T3, 100 micrograms/100 g 18 h before sacrifice) increased significantly ODC activity at all ages.	Triiodothyronine	71-73	ornithine decarboxylase 1	Rattus norvegicus	143-146
6378601-5	1984	The addition of L-T3 to the medium selectively overcame the inhibition of alpha-lactalbumin secretion by hydrocortisone.	Triiodothyronine	16-20	lactalbumin, alpha	Mus musculus	74-91
6090135-4	1984	Dibutyryladenosine 3",5"-monophosphate (Bt2cAMP) or epinephrine provoked significant increase in PEPck synthesis within 4-6 h. Simultaneous addition of T3 was found significantly to promote the Bt2cAMP-mediated enzyme induction.	Triiodothyronine	152-154	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	97-102
6089573-2	1984	Dexamethasone, thyroxine (T4), and triiodothyronine (T3) stimulated ACE activity in cells and their culture supernatants without affecting cell number or protein content.	Triiodothyronine	35-51	angiotensin I converting enzyme	Bos taurus	68-71
6089573-2	1984	Dexamethasone, thyroxine (T4), and triiodothyronine (T3) stimulated ACE activity in cells and their culture supernatants without affecting cell number or protein content.	Triiodothyronine	53-55	angiotensin I converting enzyme	Bos taurus	68-71
6378601-6	1984	Extracts of tissue cultured in the presence of L-T3 contained two distinct forms of alpha-lactalbumin, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Triiodothyronine	47-51	lactalbumin, alpha	Mus musculus	84-101
6086648-4	1984	In this study, we compared the n-butyrate and propionate modulation of receptor levels to regulation of the growth hormone and prolactin response by 3,5,3"-triiodo-L-thyronine (L-T3).	Triiodothyronine	149-175	prolactin	Rattus norvegicus	127-136
6086648-4	1984	In this study, we compared the n-butyrate and propionate modulation of receptor levels to regulation of the growth hormone and prolactin response by 3,5,3"-triiodo-L-thyronine (L-T3).	Triiodothyronine	177-181	prolactin	Rattus norvegicus	127-136
6086648-9	1984	Prolactin production, which is inhibited 25 to 50% by L-T3, was stimulated between 20- and 70-fold by L-T3 + n-butyrate (0.5-1 mM) and this decreased at higher n-butyrate levels.	Triiodothyronine	54-58	prolactin	Rattus norvegicus	0-9
6437456-0	1984	A role for intracellular calcium and calmodulin in the release of triiodothyronine from human thyroid-cell monolayer cultures.	Triiodothyronine	66-82	calmodulin 1	Homo sapiens	37-47
6541145-1	1984	The effect of a single injection of L-triiodothyronine (T3) on the levels of liver cholesterol and liver 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) has been studied in chicken.	Triiodothyronine	36-54	3-hydroxy-3-methylglutaryl-CoA reductase	Gallus gallus	105-145
6512606-0	1984	Effect of administration of triiodothyronine on aspartate aminotransferase in pyridoxine-deficient rats.	Triiodothyronine	28-44	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	48-74
6512606-1	1984	The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined.	Triiodothyronine	66-68	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	88-114
6736963-2	1984	Restoration of myelin basic protein methyltransferase to normal activities occurred 16 h after the addition of 100 nM L-3,5,3"-triiodothyronine to hypothyroid medium.	Triiodothyronine	118-143	myelin basic protein	Mus musculus	15-35
6430892-1	1984	Decreased glycero-3-phosphate (glycero-3-P) concentration, decreased output of triglyceride and glucose, increased output of apolipoprotein A-I, and increased ketogenesis were observed with isolated perfused livers from triiodothyronine-treated rats in comparison to livers from euthyroid animals.	Triiodothyronine	220-236	apolipoprotein A1	Rattus norvegicus	125-143
6541145-1	1984	The effect of a single injection of L-triiodothyronine (T3) on the levels of liver cholesterol and liver 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) has been studied in chicken.	Triiodothyronine	56-58	3-hydroxy-3-methylglutaryl-CoA reductase	Gallus gallus	105-145
6738361-0	1984	Oral triiodothyronine administration lowers plasma fibronectin levels in humans.	Triiodothyronine	5-21	fibronectin 1	Homo sapiens	51-62
6715369-0	1984	Induction of amino acid transport by L-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells).	Triiodothyronine	37-55	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
6608265-1	1984	We have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (T4) or triiodothyronine (T3).	Triiodothyronine	153-169	epidermal growth factor	Mus musculus	49-72
6728778-6	1984	Serum concentrations of corticosterone and T3 were higher in BSX than sham-operated birds at all ages.	Triiodothyronine	43-45	brain specific homeobox	Gallus gallus	61-64
6199351-2	1984	We recently reported that 3,5,3"-triiodothyronine (T3) causes a rapid increase in the translational activity of a specific mRNA (mRNAS14) coding for a protein designated "Spot 14" (Mr = 18,000; 4.9 pI) using two-dimensional gel electrophoresis of in vitro translated proteins.	Triiodothyronine	26-49	thyroid hormone responsive	Rattus norvegicus	171-178
6199351-2	1984	We recently reported that 3,5,3"-triiodothyronine (T3) causes a rapid increase in the translational activity of a specific mRNA (mRNAS14) coding for a protein designated "Spot 14" (Mr = 18,000; 4.9 pI) using two-dimensional gel electrophoresis of in vitro translated proteins.	Triiodothyronine	51-53	thyroid hormone responsive	Rattus norvegicus	171-178
6425749-6	1984	These findings suggest that the changes in serum triiodothyronine (T3) significantly influence the release of prolactin and thyroid-stimulating hormone in response to thyrotropin-releasing hormone during the periparturitional period.	Triiodothyronine	49-65	prolactin	Homo sapiens	110-119
6425749-6	1984	These findings suggest that the changes in serum triiodothyronine (T3) significantly influence the release of prolactin and thyroid-stimulating hormone in response to thyrotropin-releasing hormone during the periparturitional period.	Triiodothyronine	49-65	thyrotropin releasing hormone	Homo sapiens	167-196
6425749-6	1984	These findings suggest that the changes in serum triiodothyronine (T3) significantly influence the release of prolactin and thyroid-stimulating hormone in response to thyrotropin-releasing hormone during the periparturitional period.	Triiodothyronine	67-69	prolactin	Homo sapiens	110-119
6425749-6	1984	These findings suggest that the changes in serum triiodothyronine (T3) significantly influence the release of prolactin and thyroid-stimulating hormone in response to thyrotropin-releasing hormone during the periparturitional period.	Triiodothyronine	67-69	thyrotropin releasing hormone	Homo sapiens	167-196
6608265-1	1984	We have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (T4) or triiodothyronine (T3).	Triiodothyronine	171-173	epidermal growth factor	Mus musculus	49-72
6692402-4	1984	Upon the addition of HPRL or HGH (10 to 1000 ng/ml), in the presence of hydrocortisone, insulin, and triiodothyronine, each at 1 microgram/ml, the T-47D cells became round and refractile.	Triiodothyronine	101-117	prolactin receptor	Homo sapiens	21-25
6692402-9	1984	In addition, in the presence of hydrocortisone (or hydrocortisone, insulin, and triiodothyronine), HPRL (or HGH) retarded cell proliferation by 30%, whereas HPRL or hydrocortisone by itself had no effect on cell growth.	Triiodothyronine	80-96	prolactin receptor	Homo sapiens	99-103
6695549-0	1984	Relationship between thyroid volume and serum thyroglobulin during long-term suppression with triiodothyronine in patients with diffuse non-toxic goitre.	Triiodothyronine	94-110	thyroglobulin	Homo sapiens	46-59
6320894-6	1984	In the presence of optimal insulin concentrations (10(-7) M) triiodothyronine slightly stimulated 6-phosphogluconate dehydrogenase induction.	Triiodothyronine	61-77	insulin	Bos taurus	27-34
6320894-6	1984	In the presence of optimal insulin concentrations (10(-7) M) triiodothyronine slightly stimulated 6-phosphogluconate dehydrogenase induction.	Triiodothyronine	61-77	phosphogluconate dehydrogenase	Bos taurus	98-130
6330377-1	1984	The developmental pattern of the myelin-associated 5"-nucleotidase and its regulation by L-3,3",5,-triiodothyronine (T3) have been demonstrated in a culture system of cells dissociated from embryonic mouse brain.	Triiodothyronine	89-115	5' nucleotidase, ecto	Mus musculus	51-66
6392058-5	1984	Insulin (final concentration 0.7 I. U./ml) alone stimulated malic enzyme activity minimally, but together with triiodothyronine stimulation was additive.	Triiodothyronine	111-127	insulin	Homo sapiens	0-7
6330377-1	1984	The developmental pattern of the myelin-associated 5"-nucleotidase and its regulation by L-3,3",5,-triiodothyronine (T3) have been demonstrated in a culture system of cells dissociated from embryonic mouse brain.	Triiodothyronine	117-119	5' nucleotidase, ecto	Mus musculus	51-66
6637468-1	1983	The concentration of tri-iodothyronine (T3) and thyroxine (T4) in human milk was determined by radioimmunoassay (RIA).	Triiodothyronine	40-42	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	21-24
6141840-6	1983	The EGF-induced increase in GLU-S activity was not directly dependent on the presence of insulin, triiodothyronine, or hydrocortisone in the medium, whereas insulin was required for the stimulation of CNPase.	Triiodothyronine	98-114	epidermal growth factor	Rattus norvegicus	4-7
6644232-0	1983	Antagonism of serum tri-iodothyronine changes after injections of prolactin in the domestic fowl before and after hatching.	Triiodothyronine	20-37	prolactin	Gallus gallus	66-75
6644232-2	1983	In the chick embryo, 2 h after injection of 0.1 microgram prolactin (on incubation day 19), serum triiodothyronine (T3) increased threefold; after 10 or 100 micrograms prolactin (on incubation day 18) serum T3 increased 15- to 25-fold.	Triiodothyronine	98-114	prolactin	Gallus gallus	58-67
6644232-2	1983	In the chick embryo, 2 h after injection of 0.1 microgram prolactin (on incubation day 19), serum triiodothyronine (T3) increased threefold; after 10 or 100 micrograms prolactin (on incubation day 18) serum T3 increased 15- to 25-fold.	Triiodothyronine	116-118	prolactin	Gallus gallus	58-67
6355085-7	1983	In contrast, the induction of malic enzyme (EC 1.1.1.40, L-malate:NADP+) oxidoreductase) by insulin plus triiodothyronine was strongly suppressed by the concomitant addition of EGF.	Triiodothyronine	105-121	epidermal growth factor like 1	Rattus norvegicus	177-180
6690887-6	1984	Serum thyroxine levels decreased and serum triiodothyronine (T3) levels increased in response to growth hormone therapy.	Triiodothyronine	43-59	growth hormone 1	Homo sapiens	97-111
6690887-6	1984	Serum thyroxine levels decreased and serum triiodothyronine (T3) levels increased in response to growth hormone therapy.	Triiodothyronine	61-63	growth hormone 1	Homo sapiens	97-111
6661475-0	1983	CSF triiodothyronine (rT3) levels in patients with affective disorders.	Triiodothyronine	4-20	colony stimulating factor 2	Homo sapiens	0-3
6232160-5	1983	Serum triiodothyronine uptake to Sephadex decreased (- 17.3%), corresponding to the decrease in thyroxine/thyroxine-binding globulin ratio (- 23.8%).	Triiodothyronine	6-22	serpin family A member 7	Homo sapiens	106-132
6139387-2	1983	Somatostatin decreases the serum 3,5,3"-triiodothyronine (T3) concentration in athyreotic subjects treated with L-thyroxine (T4).	Triiodothyronine	58-60	somatostatin	Rattus norvegicus	0-12
6316072-0	1983	A case of heterozygous familial hypercholesterolemia associated with hyperthyroidism: effects of triiodothyronine on low-density lipoprotein receptor and cholesterol synthesis.	Triiodothyronine	97-113	low density lipoprotein receptor	Homo sapiens	117-149
6305272-1	1983	The regulation of glucose 6-phosphatase in hepatic microsomes by thyroid and corticosteroid hormones has been studied following the administration of 3,3",5-triiodo-L-thyronine and/or triamcinolone to hypophysectomized rats.	Triiodothyronine	150-176	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	18-39
6642415-1	1983	We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations.	Triiodothyronine	31-47	lipoprotein lipase	Homo sapiens	161-179
6642415-1	1983	We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations.	Triiodothyronine	31-47	lipase C, hepatic type	Homo sapiens	184-198
6309003-1	1983	Serum angiotensin-converting enzyme was elevated in patients with hyperthyroidism (72 +/- 31 nmol/minute/ml, n = 12, p less than 0.001) but not in patients with hypothyroidism (38 +/- 3, n = 3) or thyroiditis (26, n = 1), and was positively correlated in 23 patients with serum thyroxine concentration (r = 0.60, p less than 0.01) and triiodothyronine resin uptake (r = 0.56, p less than 0.01).	Triiodothyronine	335-351	angiotensin I converting enzyme	Homo sapiens	6-35
6407480-1	1983	Tri-iodothyronine stimulates neurotensin secretion from rat hypothalami in vitro.	Triiodothyronine	0-17	neurotensin	Rattus norvegicus	29-40
6303405-0	1983	Correlation of membrane phosphorylation and epidermal growth factor binding to hepatic membranes isolated from triiodothyronine-treated rats.	Triiodothyronine	111-127	epidermal growth factor like 1	Rattus norvegicus	44-67
6303405-1	1983	The in vivo administration of L-triiodothyronine to normal adult rats produced a reduction in the number of binding sites in hepatic membranes for epidermal growth factor; hyperthyroidism had no effect on insulin binding.	Triiodothyronine	30-48	epidermal growth factor like 1	Rattus norvegicus	147-170
6410033-10	1983	Complete suppression of TRH-induced TSH release did not occur until a daily dose of 300 micrograms triiodothyronine was administered.	Triiodothyronine	99-115	thyrotropin releasing hormone	Homo sapiens	24-27
6305272-3	1983	In intact microsomes, triiodothyronine caused a 2.3-fold increase in the Vmax of glucose 6-phosphatase; triamcinolone, a 4-fold increase; and both hormones together, a 4.4-fold increase.	Triiodothyronine	22-38	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	81-102
6305272-7	1983	Glucose 6-phosphatase was localized by a cytochemical procedure; the reaction product was associated with 90% of the profiles in all microsomal preparations, except for those from triiodothyronine-treated rats, where less than 50% contained lead precipitate.	Triiodothyronine	180-196	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	0-21
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Triiodothyronine	22-39	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	165-170
6833268-10	1983	Fibrinogen production is suppressed if an estrogen, estradiol-17 beta, is added to the culture medium together with dexamethasone and triiodothyronine.	Triiodothyronine	134-150	fibrinogen alpha chain S homeolog	Xenopus laevis	0-10
6852440-4	1983	Slight correlation between gastrin levels and serum T3 levels was observed in pretreated hyperthyroid patients (r = 0.40), but significant correlation between them was found after restoration of the euthyroid state by treatment (r = 0.50).	Triiodothyronine	52-54	gastrin	Homo sapiens	27-34
6852440-6	1983	One was a patient group whose gastrin levels correlated closely to serum T3 levels (r = 0.83, p less than 0.01).	Triiodothyronine	73-75	gastrin	Homo sapiens	30-37
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Triiodothyronine	22-39	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	308-313
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Triiodothyronine	41-43	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	165-170
6842121-2	1983	We have demonstrated a calcium-dependent release of neurotensin from incubated rat hypothalamus in response to depolarizing stimuli, as well as a dose-dependent stimulatory effect of tri-iodothyronine (T3) on neurotensin secretion.	Triiodothyronine	183-200	neurotensin	Rattus norvegicus	209-220
6842121-2	1983	We have demonstrated a calcium-dependent release of neurotensin from incubated rat hypothalamus in response to depolarizing stimuli, as well as a dose-dependent stimulatory effect of tri-iodothyronine (T3) on neurotensin secretion.	Triiodothyronine	202-204	neurotensin	Rattus norvegicus	209-220
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Triiodothyronine	41-43	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	308-313
6185489-1	1983	The regulation of the mitochondrial matrix enzyme, ornithine aminotransferase, by estrogen and triiodothyronine (T3) in rat kidney was examined using a cloned cDNA probe and in vitro translation of poly(A+) RNA.	Triiodothyronine	95-111	ornithine aminotransferase	Rattus norvegicus	51-77
6185489-1	1983	The regulation of the mitochondrial matrix enzyme, ornithine aminotransferase, by estrogen and triiodothyronine (T3) in rat kidney was examined using a cloned cDNA probe and in vitro translation of poly(A+) RNA.	Triiodothyronine	113-115	ornithine aminotransferase	Rattus norvegicus	51-77
6401233-9	1983	The model suggests that a curvilinear relationship between triiodothyronine uptake and the concentration of thyroxin-binding globulin can result in a free thyroxin index that corrects for increases in thyroglobulin binding capacity.	Triiodothyronine	59-75	serpin family A member 7	Homo sapiens	108-133
6402866-1	1983	In newly hatched chicks, TRH administration was followed by increased circulating concentrations of growth hormone (GH), thyroxine (T4) and 3,3",5-triiodothyronine (T3).	Triiodothyronine	165-167	thyrotropin releasing hormone	Gallus gallus	25-28
6401235-2	1983	Age-related variations in thyroid function tests were investigated, as was the relationship between triiodothyronine uptake and TBG.	Triiodothyronine	100-116	serpin family A member 7	Homo sapiens	128-131
6401235-5	1983	In addition, the triiodothyronine uptake correlated extremely well with TBG (r = -0.95, p less than 0.001) and was very efficient in detecting decreased and significantly increased concentrations of TBG.	Triiodothyronine	17-33	serpin family A member 7	Homo sapiens	72-75
6401235-5	1983	In addition, the triiodothyronine uptake correlated extremely well with TBG (r = -0.95, p less than 0.001) and was very efficient in detecting decreased and significantly increased concentrations of TBG.	Triiodothyronine	17-33	serpin family A member 7	Homo sapiens	199-202
6352541-2	1983	3,3",5-Tri-iodo-thyronine, 10(-8)M, stimulated 1-3H-glucosamine incorporation 300%, while insulin, 10(-6)M, led to a 70% augmentation and the combination of 10(-8)M 3,3",5-tri-iodo-thyronine and 10(-6)M insulin resulted in a 400% increase in 1-3-H-glucosamine incorporation.	Triiodothyronine	165-190	insulin	Gallus gallus	90-97
6227466-3	1983	These drugs increased the synthesis of both GH and Prl and were synergistic in stimulating an increase in GH synthesis in response to triiodothyronine, a physiological regulator of GH synthesis.	Triiodothyronine	134-150	gonadotropin releasing hormone receptor	Rattus norvegicus	106-108
6227466-3	1983	These drugs increased the synthesis of both GH and Prl and were synergistic in stimulating an increase in GH synthesis in response to triiodothyronine, a physiological regulator of GH synthesis.	Triiodothyronine	134-150	gonadotropin releasing hormone receptor	Rattus norvegicus	106-108
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	36-52	glucose-6-phosphate dehydrogenase	Homo sapiens	86-119
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	36-52	glucose-6-phosphate dehydrogenase	Homo sapiens	121-125
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	36-52	glucose-6-phosphate dehydrogenase	Homo sapiens	175-179
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	54-56	glucose-6-phosphate dehydrogenase	Homo sapiens	86-119
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	54-56	glucose-6-phosphate dehydrogenase	Homo sapiens	121-125
6317373-1	1983	Thyroid hormones, throxine (T4) and triiodothyronine (T3) which are known to activate glucose-6-phosphate dehydrogenase (G6PD) activity in vivo act as substrate inhibitors of G6PD in vitro.	Triiodothyronine	54-56	glucose-6-phosphate dehydrogenase	Homo sapiens	175-179
6840670-7	1983	hCG also induced a significant rise in the serum level of triiodothyronine in rats.	Triiodothyronine	58-74	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
7166166-3	1982	Thyroxine (200 micrograms kg-1) or triiodothyronine (40 micrograms kg-1) injected in vivo inhibited the activity of monoamine oxidase (MAO) significantly (P less than 0.05).	Triiodothyronine	35-51	monoamine oxidase A	Rattus norvegicus	116-133
6290183-0	1982	3,5,3"-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.	Triiodothyronine	0-23	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	55-88
6290183-4	1982	Although varying in the basal rate of synthesis, the T3-induced increase in PEPck synthesis was similar in intact, thyroidectomized, adrenalectomized, and hypophysectomized animals.	Triiodothyronine	53-55	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	76-81
6819989-2	1982	These effects of TRH appeared both in the medium containing a higher concentration of serum and in that containing six growth factors, i.e. insulin, transferrin, parathyroid hormone, fibroblast growth factor, triiodothyronine, and multiplication-stimulating activity (MSA) instead of serum.	Triiodothyronine	209-225	thyrotropin releasing hormone	Rattus norvegicus	17-20
7166166-3	1982	Thyroxine (200 micrograms kg-1) or triiodothyronine (40 micrograms kg-1) injected in vivo inhibited the activity of monoamine oxidase (MAO) significantly (P less than 0.05).	Triiodothyronine	35-51	monoamine oxidase A	Rattus norvegicus	135-138
6815912-0	1982	[The behavior of the thyrotropin-releasing hormone test in fasting with and without triiodothyronine administration].	Triiodothyronine	84-100	thyrotropin releasing hormone	Homo sapiens	21-50
6816614-6	1982	The increase in hepatic lipase activities was significantly correlated to the increase in serum triiodothyronine levels and also to the reduction in LDL cholesterol concentrations.	Triiodothyronine	96-112	lipase C, hepatic type	Homo sapiens	16-30
6816614-8	1982	In two patients initially treated with triiodothyronine, the activity of hepatic lipase, but not that of lipoprotein lipase, increased after 24 and 48 h, while LDL cholesterol levels decreased substantially.	Triiodothyronine	39-55	lipase C, hepatic type	Homo sapiens	73-87
6816614-9	1982	We suggest that the reduced activities of hepatic lipase as well as of lipoprotein lipase are important pathogenetic factors for the dyslipoproteinaemia occurring in hypothyroidism and that the low serum triiodothyronine concentration is of major importance for the alterations in lipid transport.	Triiodothyronine	204-220	lipase C, hepatic type	Homo sapiens	42-56
6286288-0	1982	Age-related differences in the response of hepatic microsomal glucose-6-phosphatase to triiodothyronine and triamcinolone in the rat.	Triiodothyronine	87-103	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	62-83
6816881-1	1982	Hyperalphalipoproteinemia, characterized by increased plasma concentrations of apoA-I and of HDL lipid and protein, was observed in rats treated with triiodothyronine (T(3)) for 7 days.	Triiodothyronine	150-166	apolipoprotein A1	Rattus norvegicus	79-85
6816881-1	1982	Hyperalphalipoproteinemia, characterized by increased plasma concentrations of apoA-I and of HDL lipid and protein, was observed in rats treated with triiodothyronine (T(3)) for 7 days.	Triiodothyronine	168-172	apolipoprotein A1	Rattus norvegicus	79-85
6816881-6	1982	An enhanced release of apoA-I by perfused livers isolated from rats treated with T(3) was also observed; this enhanced output of apoA-I may explain, in part, the hyperalphalipoproteinemia observed in these rats.	Triiodothyronine	81-85	apolipoprotein A1	Rattus norvegicus	23-29
6816881-6	1982	An enhanced release of apoA-I by perfused livers isolated from rats treated with T(3) was also observed; this enhanced output of apoA-I may explain, in part, the hyperalphalipoproteinemia observed in these rats.	Triiodothyronine	81-85	apolipoprotein A1	Rattus norvegicus	129-135
6294916-4	1982	When the aged subjects and the atherosclerotic patients were administered with triiodothyronine prior to ACTH, their metabolic responses to ACTH improved towards normal.	Triiodothyronine	79-95	proopiomelanocortin	Homo sapiens	105-109
6294916-4	1982	When the aged subjects and the atherosclerotic patients were administered with triiodothyronine prior to ACTH, their metabolic responses to ACTH improved towards normal.	Triiodothyronine	79-95	proopiomelanocortin	Homo sapiens	140-144
6287840-4	1982	In addition, this abnormal protein, like thyroxine-binding globulin, bound 125I-labeled triiodothyronine and 125I-labeled reverse triiodothyronine.	Triiodothyronine	88-104	serpin family A member 7	Homo sapiens	41-67
6287840-4	1982	In addition, this abnormal protein, like thyroxine-binding globulin, bound 125I-labeled triiodothyronine and 125I-labeled reverse triiodothyronine.	Triiodothyronine	130-146	serpin family A member 7	Homo sapiens	41-67
6290858-0	1982	Cytochrome c reduction by triiodothyronine (T3).	Triiodothyronine	26-42	cytochrome c, somatic	Homo sapiens	0-12
6290858-0	1982	Cytochrome c reduction by triiodothyronine (T3).	Triiodothyronine	44-46	cytochrome c, somatic	Homo sapiens	0-12
6290858-1	1982	Triiodothyronine (T3), the active thyroid hormone, reduced cytochrome c non-enzymatically.	Triiodothyronine	0-16	cytochrome c, somatic	Homo sapiens	59-71
6290858-1	1982	Triiodothyronine (T3), the active thyroid hormone, reduced cytochrome c non-enzymatically.	Triiodothyronine	18-20	cytochrome c, somatic	Homo sapiens	59-71
7042057-0	1982	Interaction of gastric inhibitory polypeptide and arginine with glucose in the perfused pancreas of rats treated with triiodothyronine.	Triiodothyronine	118-134	gastric inhibitory polypeptide	Rattus norvegicus	15-45
6179765-4	1982	However, when the addition of L-T3 was delayed by 48 h following culture with insulin, cortisol and prolactin, the synthesis of lipids was increased between 96--99 h of culture by 48%.	Triiodothyronine	30-34	insulin	Capra hircus	78-85
6280965-1	1982	Electrophoretic analysis of soluble proteins from pituitary cells pulse labeled with [35S]methionine demonstrated that 10 nM T3 inhibited PRL synthesis, but did not affect the synthesis of most other pituitary proteins.	Triiodothyronine	125-127	prolactin	Homo sapiens	138-141
6120761-10	1982	The constitutive or autogenous nature of the GGT phenotype in rat hepatoma cells was demonstrated by the retention of the GGT-positive and GGT-negative phenotypes of two strains grown in mixed culture; the lack of change in GGT activity when cells were cultured on different substrata, in different media, or in media containing hormones (insulin, dexamethasone, triiodothyronine, or glucagon); and the assumption of nearly constant levels of GGT specific activity in late log or stationary cultures.	Triiodothyronine	363-379	gamma-glutamyltransferase 1	Rattus norvegicus	45-48
6803486-2	1982	Seventeen of th 29 members of the kindred have the increased TBG trait as demonstrated by a combination of increased serum total thyroxine (T4) and total triiodothyronine (T3) and decreased T3 resin uptake.	Triiodothyronine	154-170	serpin family A member 7	Homo sapiens	61-64
6803486-2	1982	Seventeen of th 29 members of the kindred have the increased TBG trait as demonstrated by a combination of increased serum total thyroxine (T4) and total triiodothyronine (T3) and decreased T3 resin uptake.	Triiodothyronine	172-174	serpin family A member 7	Homo sapiens	61-64
7042057-4	1982	Arginine and gastric inhibitory polypeptide (GIP) induced an insulinotropic action in both control and T3-treated preparations.	Triiodothyronine	103-105	gastric inhibitory polypeptide	Rattus norvegicus	13-43
7042057-4	1982	Arginine and gastric inhibitory polypeptide (GIP) induced an insulinotropic action in both control and T3-treated preparations.	Triiodothyronine	103-105	gastric inhibitory polypeptide	Rattus norvegicus	45-48
7042057-6	1982	The insulinotropic effect of both arginine and GIP was abolished by mannoheptulose in both control and T3-treated animals.	Triiodothyronine	103-105	gastric inhibitory polypeptide	Rattus norvegicus	47-50
6172984-4	1981	ODC was stimulated above control (100%) with the following factors: parathyroid hormone (PTH) (555 +/- 15%), BtcAMP (324 +/- 34%), 1-methyl-3-isobutylxanthine (MIX) (223 +/- 6%), prostaglandin E1 (PGE1) (227 +/- 15%), 3,3",5-triiodothyronine (T3) (184 +/- 22%), insulin (182 +/- 14%), multiplication-stimulating activity (MSA) (178 +/- 6%), 5% rat serum (253 +/- 57%).	Triiodothyronine	218-241	ornithine decarboxylase	Gallus gallus	0-3
6276146-1	1982	Triiodothyronine (T3) rapidly induces the accumulation of two hepatic mRNA sequences (spot 14 and spot CyT) in thyroidectomized rats as revealed by two-dimensional gel electrophoresis of in vitro translated products of isolated poly(A) containing RNA.	Triiodothyronine	0-16	thyroid hormone responsive	Rattus norvegicus	86-93
6276146-1	1982	Triiodothyronine (T3) rapidly induces the accumulation of two hepatic mRNA sequences (spot 14 and spot CyT) in thyroidectomized rats as revealed by two-dimensional gel electrophoresis of in vitro translated products of isolated poly(A) containing RNA.	Triiodothyronine	18-20	thyroid hormone responsive	Rattus norvegicus	86-93
6815406-0	1982	[Effects of thyroxine and triiodothyronine on the thyrotropin response to the thyrotropin releasing hormone in the rat].	Triiodothyronine	26-42	thyrotropin releasing hormone	Rattus norvegicus	78-107
6172984-4	1981	ODC was stimulated above control (100%) with the following factors: parathyroid hormone (PTH) (555 +/- 15%), BtcAMP (324 +/- 34%), 1-methyl-3-isobutylxanthine (MIX) (223 +/- 6%), prostaglandin E1 (PGE1) (227 +/- 15%), 3,3",5-triiodothyronine (T3) (184 +/- 22%), insulin (182 +/- 14%), multiplication-stimulating activity (MSA) (178 +/- 6%), 5% rat serum (253 +/- 57%).	Triiodothyronine	243-245	ornithine decarboxylase	Gallus gallus	0-3
6172984-6	1981	Actinomycin D (1 microgram/ml) inhibited stimulation of ODC activity by T3 and the cyclic AMP-mediated factors (PTH, BtcAMP, MIX, PGE1), but had only minimal effects on ODC stimulation by insulin, MSA, or serum.	Triiodothyronine	72-74	ornithine decarboxylase	Gallus gallus	56-59
6801212-1	1981	In 52 patients with myasthenia gravis serum myoglobin showed a significant inverse correlation to circulating thyroxine and triiodothyronine levels.	Triiodothyronine	124-140	myoglobin	Homo sapiens	44-53
6793590-2	1981	To determine the relative contributions of glucose, insulin, dexamethasone, and triiodothyronine to the induction of hepatic glucose-6-phosphate dehydrogenase, hepatocytes isolated from normal or adrenalectomized rats, either fasted or fed, were examined in culture.	Triiodothyronine	80-96	glucose-6-phosphate dehydrogenase	Rattus norvegicus	125-158
7028136-0	1981	Triiodothyronine and growth hormone exert an opposite effect on the binding of growth hormone and insulin by hepatocytes from dwarf mouse.	Triiodothyronine	0-16	growth hormone	Mus musculus	79-93
7028136-0	1981	Triiodothyronine and growth hormone exert an opposite effect on the binding of growth hormone and insulin by hepatocytes from dwarf mouse.	Triiodothyronine	0-16	insulin	Bos taurus	98-105
7285875-1	1981	L-triiodothyronine induces a three-fold increase in growth hormone production in cultured GH1 cells.	Triiodothyronine	0-18	gonadotropin releasing hormone receptor	Rattus norvegicus	52-66
6797816-2	1981	Administration of oral TRH to each of 14 acromegalics resulted in more pronounced TSH response in all patients and more pronounced response of triiodothyronine in most of them (delta max TSh after oral TRh 36.4 +/- 10.0 (SEM) mU/l vs. delta max TSH after i.v.	Triiodothyronine	143-159	thyrotropin releasing hormone	Homo sapiens	23-26
6266056-3	1981	It has been shown that the H2O2/l ratio exerts a controlling influence on MPO-catalysed reactions of fully iodinated tyrosines, e.g. di-iodotyrosine, and of partially and completely iodinated thyronines such as thyroxine and tri-iodothyronine.	Triiodothyronine	225-242	myeloperoxidase	Homo sapiens	74-77
6268753-1	1981	The direct influence of L-3,3",5-triiodothyronine (T3) on the development of 2",3"-cyclic nucleotide 3"-phosphohydrolase (EC 3.1.4.37, CNPase) is demonstrated by using an in vitro culture system of dissociated embryonic mouse brain cells.	Triiodothyronine	24-49	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	135-141
6796298-1	1981	The non-steroidal anti-inflammatory agent fenclofenac competitively inhibits the binding of thyroxine(T4) and triiodothyronine (T3) by thyroxine-binding globulin(TBG).	Triiodothyronine	110-126	serpin family A member 7	Homo sapiens	162-165
6796298-1	1981	The non-steroidal anti-inflammatory agent fenclofenac competitively inhibits the binding of thyroxine(T4) and triiodothyronine (T3) by thyroxine-binding globulin(TBG).	Triiodothyronine	128-130	serpin family A member 7	Homo sapiens	162-165
6266056-5	1981	The action of MPO on iodothyronine substrates only affects de-iodination irrespective of whether the iodothyronine is partially iodinated, as in tri-iodothyronine, or completely iodinated, as in thyroxine.	Triiodothyronine	145-162	myeloperoxidase	Homo sapiens	14-17
6266056-6	1981	This MPO-catalysed de-iodination of thyroxine and tri-iodothyronine can also be regulated by the H2O2/l ratio.	Triiodothyronine	50-67	myeloperoxidase	Homo sapiens	5-8
7237797-3	1981	The relation between triiodothyronine uptake and thyroxine-binding globulin concentrations was established by use of sera from euthyroid individuals.	Triiodothyronine	21-37	serpin family A member 7	Homo sapiens	49-75
7237797-4	1981	We examined the effects of both high (greater than 20 mg/L) and low (less than 10 mg/L) thyroxine-binding globulin concentrations on triiodothyronine uptake.	Triiodothyronine	133-149	serpin family A member 7	Homo sapiens	88-114
6785072-6	1981	Perifusion with 3.5 x 10(-5) M cycloheximide or 10(-6) M actinomycin D 1 h before and during T3 administration led to greater TSH release with TRH than in the presence of T3 alone.	Triiodothyronine	93-95	thyrotropin releasing hormone	Rattus norvegicus	143-146
6793565-0	1981	Induction of epidermal growth factor by tri-iodo-L-thyronine in the submandibular glands of mice with testicular feminization.	Triiodothyronine	40-60	epidermal growth factor	Mus musculus	13-36
6793565-2	1981	In female mice, the amount of HMW-EGF was increased 10-fold by tri-iodo-L-thyronine (T3) and 60-fold by 5 alpha-dihydrotestosterone (5 alpha-DHT).	Triiodothyronine	63-83	epidermal growth factor	Mus musculus	34-37
6793565-2	1981	In female mice, the amount of HMW-EGF was increased 10-fold by tri-iodo-L-thyronine (T3) and 60-fold by 5 alpha-dihydrotestosterone (5 alpha-DHT).	Triiodothyronine	85-87	epidermal growth factor	Mus musculus	34-37
7291145-3	1981	In patients with thyrotoxicosis, a remarkable increase in prolactin level, which correlated with triiodothyronine content, was observed.	Triiodothyronine	97-113	prolactin	Homo sapiens	58-67
7238537-8	1981	After uptake of thyroglobulin, thyroxine and triiodothyronine are released by follicle cells and accumulate in the culture medium.	Triiodothyronine	45-61	thyroglobulin	Sus scrofa	16-29
6781877-2	1981	During 6 days of culture in the presence of insulin, cortisol, prolactin and triiodothyronine mammary explants accumulated progressively increasing amounts of alpha-lactalbumin.	Triiodothyronine	77-93	lactalbumin, alpha	Mus musculus	159-176
7013808-3	1981	In vitro, in the presence of insulin, the addition of a hormone mixture containing hydrocortisone, glucagon, somatotropin, and triiodothyronine resulted in a 70% increase in leucine incorporation into haptoglobin relative to albumin at 48 h incubation.	Triiodothyronine	127-143	haptoglobin	Rattus norvegicus	201-212
6941282-6	1981	The results were comparable from both techniques and showed that incubation of GH3 cells with a thyroid hormone (triiodothyronine), a glucocorticoid hormone (dexamethasone), or both hormones caused an increase of cytoplasmic pre-GH mRNA sequences of about 4-, 22-, and 13-fold, respectively.	Triiodothyronine	113-129	gonadotropin releasing hormone receptor	Rattus norvegicus	79-81
7005000-0	1981	Effects of thyroidectomy and triiodothyronine administration on rat liver alcohol dehydrogenase.	Triiodothyronine	29-45	aldo-keto reductase family 1 member A1	Rattus norvegicus	74-95
7005000-5	1981	Inhibition of alcohol dehydrogenase by triiodothyronine in vitro was found to be competitive with respect to NAD+ and uncompetitive with respect to ethanol in both contrast and thyroidectomized animals.	Triiodothyronine	39-55	aldo-keto reductase family 1 member A1	Rattus norvegicus	14-35
7451459-3	1981	Addition of physiological concentrations (10 nM) of triiodothyronine or thyroxine produced 3-fold or greater increases in the rates of synthesis of fibrinogen and three other major secreted proteins.	Triiodothyronine	52-68	fibrinogen gamma chain	Gallus gallus	148-158
6455047-0	1981	Thyrotropin releasing hormone (TRH): its changes in discrete hypothalamic areas after treatment with triiodothyronine, thyroidectomy and acute cold exposure.	Triiodothyronine	101-117	thyrotropin releasing hormone	Rattus norvegicus	0-29
6455047-0	1981	Thyrotropin releasing hormone (TRH): its changes in discrete hypothalamic areas after treatment with triiodothyronine, thyroidectomy and acute cold exposure.	Triiodothyronine	101-117	thyrotropin releasing hormone	Rattus norvegicus	31-34
7004859-2	1981	prolactin, corticosterone, insulin, and triiodothyronine effects on alpha-lactalbumin production.	Triiodothyronine	40-56	lactalbumin alpha	Homo sapiens	68-85
7462429-1	1981	Differences in the growth hormone (GH) responses to primary and to secondary stimulation with triiodothyronine (T3) were studied in rats deprived of thyroid hormone from birth.	Triiodothyronine	94-110	gonadotropin releasing hormone receptor	Rattus norvegicus	19-33
7462429-1	1981	Differences in the growth hormone (GH) responses to primary and to secondary stimulation with triiodothyronine (T3) were studied in rats deprived of thyroid hormone from birth.	Triiodothyronine	94-110	gonadotropin releasing hormone receptor	Rattus norvegicus	35-37
7215332-3	1981	Treatment of hypophysectomized rats with L-triiodothyronine increased the activities of cholesterol esterase and hyaluronidase approximately 2-fold in liver cell fractions.	Triiodothyronine	41-59	carboxyl ester lipase	Rattus norvegicus	88-108
7202662-1	1981	The effect of thyroidectomy and subsequent treatment with tri-iodothyronine (T3), as well as that of thyrotoxicosis, was examined on cathepsin D activity in the rat liver, kidney and brain.	Triiodothyronine	58-75	cathepsin D	Rattus norvegicus	133-144
7202662-1	1981	The effect of thyroidectomy and subsequent treatment with tri-iodothyronine (T3), as well as that of thyrotoxicosis, was examined on cathepsin D activity in the rat liver, kidney and brain.	Triiodothyronine	77-79	cathepsin D	Rattus norvegicus	133-144
6106142-0	1980	Separate mechanisms of induction for ornithine decarboxylase by triiodothyronine and aminophylline.	Triiodothyronine	64-80	ornithine decarboxylase 1	Homo sapiens	37-60
7460818-0	1981	Effects of triiodothyronine and thyroxine on thyrotropin and prolactin secretion from bovine pituitary cells in vitro.	Triiodothyronine	11-27	prolactin	Bos taurus	61-70
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	46-62	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	46-62	thyroglobulin	Homo sapiens	252-265
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	217-233	thyroglobulin	Homo sapiens	107-120
6250215-1	1980	Limited deoxyribonuclease I and micrococcal nuclease digestion of hepatic nuclei from euthyroid rats injected with 125I-labeled triiodothyronine ([125I]T3)  releases a discrete [125I]T3-labeled chromatin fragment (5.8S) which is larger than the T3 receptor (3.5S).	Triiodothyronine	128-144	deoxyribonuclease 1	Rattus norvegicus	8-27
7208169-0	1981	Action of human growth hormone (hGH) on extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3) in children with hypopituitarism.	Triiodothyronine	87-103	growth hormone 1	Homo sapiens	16-30
7208169-0	1981	Action of human growth hormone (hGH) on extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3) in children with hypopituitarism.	Triiodothyronine	105-107	growth hormone 1	Homo sapiens	16-30
6775931-0	1980	Effects of triiodothyronine on thyrotropin-releasing hormone-induced thyrotropin release in the neonatal rat.	Triiodothyronine	11-27	thyrotropin releasing hormone	Rattus norvegicus	31-60
7417792-1	1980	Triiodothyronine (30 nM) added to serum-free cultures of mechanically dissociated re-aggregating fetal (15-16 days gestation) rat brain cells greatly increased the enzymatic activity of choline acetyltransferase and acetylcholinesterase throughout the entire culture period (33 days), and markedly accelerated the developmental rise of glutamic acid decarboxylase specific activity.	Triiodothyronine	0-16	choline O-acetyltransferase	Rattus norvegicus	186-211
7417792-1	1980	Triiodothyronine (30 nM) added to serum-free cultures of mechanically dissociated re-aggregating fetal (15-16 days gestation) rat brain cells greatly increased the enzymatic activity of choline acetyltransferase and acetylcholinesterase throughout the entire culture period (33 days), and markedly accelerated the developmental rise of glutamic acid decarboxylase specific activity.	Triiodothyronine	0-16	acetylcholinesterase	Rattus norvegicus	216-236
7417792-2	1980	The enhancement of choline acetyltransferase and acetylcholinesterase specific activities in the presence of triiodothyronine was even more pronouned in cultures of telencephalic cells.	Triiodothyronine	109-125	choline O-acetyltransferase	Rattus norvegicus	19-44
7417792-2	1980	The enhancement of choline acetyltransferase and acetylcholinesterase specific activities in the presence of triiodothyronine was even more pronouned in cultures of telencephalic cells.	Triiodothyronine	109-125	acetylcholinesterase	Rattus norvegicus	49-69
7417792-3	1980	If triiodothyronine treatment was restricted to the first 17 culture days, the level of choline acetyltransferase specific activity at day 33 was 84% of that in chronically treated cultures and 270% of that in cultures receiving triiodothyronine between days 17 and 33, indicating that relatively undifferentiated cells were more responsive to the hormone.	Triiodothyronine	3-19	choline O-acetyltransferase	Rattus norvegicus	88-113
7417792-3	1980	If triiodothyronine treatment was restricted to the first 17 culture days, the level of choline acetyltransferase specific activity at day 33 was 84% of that in chronically treated cultures and 270% of that in cultures receiving triiodothyronine between days 17 and 33, indicating that relatively undifferentiated cells were more responsive to the hormone.	Triiodothyronine	229-245	choline O-acetyltransferase	Rattus norvegicus	88-113
6252249-10	1980	Triiodothyronine and parathyroid hormone increased the incorporation of [3H]thymidine and were additive to IGF I.	Triiodothyronine	0-16	insulin-like growth factor 1	Rattus norvegicus	107-112
7209295-3	1980	In addition, the concentrations of myoglobin, creatine kinase and lactate dehydrogenase values were inversely related to both the thyroxine and triiodothyronine concentrations.	Triiodothyronine	144-160	myoglobin	Homo sapiens	35-44
6893960-4	1980	There was a positive and significant correlation between changes in DBH activity and triiodothyronine caused by propranolol.	Triiodothyronine	85-101	dopamine beta-hydroxylase	Homo sapiens	68-71
6893960-5	1980	These data offer evidence that there may be an interaction between plasma DBH activity and triiodothyronine during propranolol administration in hyperthyroidism.	Triiodothyronine	91-107	dopamine beta-hydroxylase	Homo sapiens	74-77
114519-7	1979	The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids.	Triiodothyronine	92-108	insulin	Gallus gallus	16-23
7391078-0	1980	Effects of hypophysectomy and triiodothyronine on de novo biosynthesis, catalytic activity, and estrogen induction of rat liver histidase.	Triiodothyronine	30-46	histidine ammonia lyase	Rattus norvegicus	128-137
7391078-3	1980	Treatment of hypophysectomized rats with physiological levels of triiodothyronine (T3) diminished histidase synthetic rates and catalytic activities to normal levels, despite concomitant elevation in total soluble protein synthesis.	Triiodothyronine	65-81	histidine ammonia lyase	Rattus norvegicus	98-107
7391078-3	1980	Treatment of hypophysectomized rats with physiological levels of triiodothyronine (T3) diminished histidase synthetic rates and catalytic activities to normal levels, despite concomitant elevation in total soluble protein synthesis.	Triiodothyronine	83-85	histidine ammonia lyase	Rattus norvegicus	98-107
231627-1	1979	Esteroprotease, an androgen-dependent enzyme of the mouse submandibular gland, was increased by injection of tri-iodothyronine (T3) in mice with testicular feminization (Tfm) which are genetically deficient in androgen receptors.	Triiodothyronine	109-126	androgen receptor	Mus musculus	170-173
231627-1	1979	Esteroprotease, an androgen-dependent enzyme of the mouse submandibular gland, was increased by injection of tri-iodothyronine (T3) in mice with testicular feminization (Tfm) which are genetically deficient in androgen receptors.	Triiodothyronine	128-130	androgen receptor	Mus musculus	170-173
41714-0	1979	The role of growth hormone, dexamethasone and triiodothyronine in the regulation of glutamine synthetase in primary cultures of rat hepatocytes.	Triiodothyronine	46-62	glutamate-ammonia ligase	Rattus norvegicus	84-104
119318-22	1979	TRH, a marked increase in T3 could be demonstrated (0.5 +/- 0.1 ng/ml and 0.6 +/- 0.1 ng/ml in "non-responders" and "low-responders" respectively, p less than 0.01); thus, oral administration allows simultaneous stimulation of TSH and triiodothyronine.	Triiodothyronine	235-251	thyrotropin releasing hormone	Homo sapiens	0-3
396977-0	1979	Effect of insulin-induced hypoglycemia on the serum concentrations of thyroxine, triiodothyronine and reverse triiodothyronine.	Triiodothyronine	81-97	insulin	Homo sapiens	10-17
396977-0	1979	Effect of insulin-induced hypoglycemia on the serum concentrations of thyroxine, triiodothyronine and reverse triiodothyronine.	Triiodothyronine	110-126	insulin	Homo sapiens	10-17
114519-7	1979	The addition of insulin, or insulin plus hydrocortisone or insulin plus hydrocortisone plus triiodothyronine, was important for the maintenance of protein synthesis and essential for maximal expression of the ability of steroids to induce porphyrins and ALA-synthase in the "permissive" effect which insulin, hydrocortisone, and triiodothyronine exert on allylisopropylacetamide induction of porphyrins and ALA-synthase also extends to the induction process which is elicited by natural steroids.	Triiodothyronine	329-345	insulin	Gallus gallus	16-23
396977-3	1979	However, the T(3) concentrations rose from a mean basal level of 1.86 +/- 0.06 mug/l to a mean peak of 2.51 +/- 0.21 mug/l (P &lt; 0.01) at 45 minutes after the insulin injection, and the rT(3) concentrations fell from a mean basal level of 0.184 +/- 0.008 mug/l to a mean nadir of 0.171 +/- 0.022 mug/l (not a significant change).	Triiodothyronine	13-17	insulin	Homo sapiens	161-168
110492-1	1979	The relationship between serum tri-iodothyronine (T3) and thyroxine-binding globulin (TBG) has been studied in euthyroid subjects.	Triiodothyronine	31-48	serpin family A member 7	Homo sapiens	58-84
227208-9	1979	We postulate that the fundamental defect in this gland is an impaired generation of c-AMP by the defective thyroid cell and deficiency of thyroglobulin formation resulting in inadequate thyroxine and triiodothyronine synthesis.	Triiodothyronine	200-216	thyroglobulin	Homo sapiens	138-151
41520-22	1979	Treatment of liver cells with beta-glucosidase, Pronase and neuraminidase led to a decrease in the uptake of L-tri-iodothyronine by system I, whereas uptake by system II was decreased after treatment with phospholipase A2, beta-galactosidase.	Triiodothyronine	109-128	phospholipase A2 group IB	Rattus norvegicus	205-221
41520-22	1979	Treatment of liver cells with beta-glucosidase, Pronase and neuraminidase led to a decrease in the uptake of L-tri-iodothyronine by system I, whereas uptake by system II was decreased after treatment with phospholipase A2, beta-galactosidase.	Triiodothyronine	109-128	galactosidase, beta 1	Rattus norvegicus	223-241
92043-7	1979	It was demonstrated, further, that an inverse relationship (r = -0.7593) existed between the TBG level and serum triiodothyronine uptake index, and that a direct relation (r = +0.6557) was present between the TBG level and T4 in sera from normal subjects and pregnancy.	Triiodothyronine	113-129	serpin family A member 7	Homo sapiens	93-96
110492-1	1979	The relationship between serum tri-iodothyronine (T3) and thyroxine-binding globulin (TBG) has been studied in euthyroid subjects.	Triiodothyronine	31-48	serpin family A member 7	Homo sapiens	86-89
110492-1	1979	The relationship between serum tri-iodothyronine (T3) and thyroxine-binding globulin (TBG) has been studied in euthyroid subjects.	Triiodothyronine	50-52	serpin family A member 7	Homo sapiens	58-84
110492-1	1979	The relationship between serum tri-iodothyronine (T3) and thyroxine-binding globulin (TBG) has been studied in euthyroid subjects.	Triiodothyronine	50-52	serpin family A member 7	Homo sapiens	86-89
435519-3	1979	L-Triiodothyronine also evokes a rapid increase in acid lipase activity, and this increase can be inhibited by coadministration of actinomycin D.	Triiodothyronine	0-18	lipase G, endothelial type	Rattus norvegicus	56-62
221536-0	1979	Relationship of receptor affinity to the modulation of thyroid hormone nuclear receptor levels and growth hormone synthesis by L-triiodothyronine and iodothyronine analogues in cultured GH1 cells.	Triiodothyronine	127-145	gonadotropin releasing hormone receptor	Rattus norvegicus	99-113
221536-1	1979	We have previously demonstrated that L-triiodothyronine (L-T3) induces an increase in growth hormone synthesis and messenger RNA in cultured GH1 cells, a rat pituitary cell line.	Triiodothyronine	37-55	gonadotropin releasing hormone receptor	Rattus norvegicus	86-100
221536-1	1979	We have previously demonstrated that L-triiodothyronine (L-T3) induces an increase in growth hormone synthesis and messenger RNA in cultured GH1 cells, a rat pituitary cell line.	Triiodothyronine	57-61	gonadotropin releasing hormone receptor	Rattus norvegicus	86-100
122323-0	1979	The rate of total triiodothyronine to thyroxine-binding globulin as an index of free triiodothyronine in human serum.	Triiodothyronine	85-101	serpin family A member 7	Homo sapiens	38-64
573997-1	1979	Exposure of male CSF rats to a signalled unpredictable 60-day stress regimen induced a significant elevation in circulating triiodothyronine (T3) concentration above the control for the first 20 days of stress before the rate of secretion returned to normal.	Triiodothyronine	124-140	colony stimulating factor 2	Rattus norvegicus	17-20
573997-1	1979	Exposure of male CSF rats to a signalled unpredictable 60-day stress regimen induced a significant elevation in circulating triiodothyronine (T3) concentration above the control for the first 20 days of stress before the rate of secretion returned to normal.	Triiodothyronine	142-144	colony stimulating factor 2	Rattus norvegicus	17-20
113139-2	1979	In one patient treated with intravenous T3, 50 micrograms daily for 10 days, the peak serum TSH and total pituitary TSH reserve after TRH increased coincident with increases in serum T3 and T4 levels and a decrease in the basal TSH concentration.	Triiodothyronine	40-42	thyrotropin releasing hormone	Homo sapiens	134-137
760516-5	1979	Substitution of levothyroxine for thyroglobulin was done in all patients and was associated with return to normal of serum triiodothyronine (T3) values in those tested.	Triiodothyronine	123-139	thyroglobulin	Homo sapiens	34-47
760516-5	1979	Substitution of levothyroxine for thyroglobulin was done in all patients and was associated with return to normal of serum triiodothyronine (T3) values in those tested.	Triiodothyronine	141-143	thyroglobulin	Homo sapiens	34-47
33057-0	1978	Effect of triiodothyronine on glutamine synthetase in the developing rat retina.	Triiodothyronine	10-26	glutamate-ammonia ligase	Rattus norvegicus	30-50
118103-0	1979	Effect of triiodothyronine administration on the plasma TSH and prolactin responses to TRH in patients with hypothalamic-pituitary insufficiency.	Triiodothyronine	10-26	prolactin	Homo sapiens	64-73
118103-0	1979	Effect of triiodothyronine administration on the plasma TSH and prolactin responses to TRH in patients with hypothalamic-pituitary insufficiency.	Triiodothyronine	10-26	thyrotropin releasing hormone	Homo sapiens	87-90
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	250-266	prolactin	Homo sapiens	151-160
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	250-266	prolactin	Homo sapiens	162-165
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	250-266	thyrotropin releasing hormone	Homo sapiens	170-199
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	250-266	thyrotropin releasing hormone	Homo sapiens	201-204
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	268-270	prolactin	Homo sapiens	151-160
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	268-270	prolactin	Homo sapiens	162-165
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	268-270	thyrotropin releasing hormone	Homo sapiens	170-199
118103-1	1979	A study was carried out in 10 patients with multiple pituitary hormone deficiencies to determine the response of thyroid-stimulating hormone (TSH) and prolactin (PRL) to thyrotropin-releasing hormone (TRH) and their suppressibility by treatment with triiodothyronine (T3) given at a dose of 60 microgram/day for 1 week.	Triiodothyronine	268-270	thyrotropin releasing hormone	Homo sapiens	201-204
544106-0	1979	[The measurement of serum triiodothyronine uptake with anti-T3 antibody coated tube : Basic and clinical evaluation of Gamma Coat T3 Uptake Kit (author"s transl)].	Triiodothyronine	26-42	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	140-143
103659-3	1978	The ratio allows a more precise selection of the borderline cases requiring Thyroid Stimulating Hormone and triiodothyronine assays, particularly when the serum TBG is raised or lowered.	Triiodothyronine	108-124	serpin family A member 7	Homo sapiens	161-164
213445-0	1978	Relationship between the accumulation of pituitary growth hormone and nuclear occupancy by triiodothyronine in the rat.	Triiodothyronine	91-107	gonadotropin releasing hormone receptor	Rattus norvegicus	51-65
213445-2	1978	pulse injections of triiodothyronine (T(3)) and to calculate the relationship between nuclear occupancy by T(3) and the instantaneous rate of accumulation of pituitary GH.	Triiodothyronine	107-111	gonadotropin releasing hormone receptor	Rattus norvegicus	168-170
213447-2	1978	Incubation of thyrotropes with 100 nM TRH or 4 nM L-triiodothyronine (T3) for 48 h decreased the number of TRH receptors to approximately equal to 50 and 20% of control, respectively.	Triiodothyronine	50-68	thyrotropin releasing hormone	Mus musculus	107-110
213447-2	1978	Incubation of thyrotropes with 100 nM TRH or 4 nM L-triiodothyronine (T3) for 48 h decreased the number of TRH receptors to approximately equal to 50 and 20% of control, respectively.	Triiodothyronine	70-72	thyrotropin releasing hormone	Mus musculus	107-110
716427-0	1978	[Hyperthyroidism with selective increase in the serum of triiodothyronine level (T-3 toxicosis)].	Triiodothyronine	57-73	solute carrier family 25 member 5	Homo sapiens	81-84
414908-0	1977	Effect of triiodothyronine on thyroliberin-induced somatotropin release in patients with acromegaly.	Triiodothyronine	10-26	growth hormone 1	Homo sapiens	51-63
657566-0	1978	[Triiodothyronine uptake by Konsul T3 Uptake Kit].	Triiodothyronine	1-17	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-48
80734-2	1978	Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum.	Triiodothyronine	14-30	thyrotropin releasing hormone	Rattus norvegicus	116-119
80734-2	1978	Serum TSH and triiodothyronine (T3) responses to cold exposure (4 +/- 1 C) were abolished by administration of anti-TRH serum.	Triiodothyronine	32-34	thyrotropin releasing hormone	Rattus norvegicus	116-119
213036-3	1978	Triiodothyronine (T3) and thyroxine (T4) blocked an increase of TSH secretion produced by TRH, but they elevated pituitary concentration of cyclic AMP in vivo and in vitro.	Triiodothyronine	0-16	thyrotropin releasing hormone	Homo sapiens	90-93
213036-3	1978	Triiodothyronine (T3) and thyroxine (T4) blocked an increase of TSH secretion produced by TRH, but they elevated pituitary concentration of cyclic AMP in vivo and in vitro.	Triiodothyronine	18-20	thyrotropin releasing hormone	Homo sapiens	90-93
351773-0	1978	[Pituitary response to synthetic LH-RH stimulus in patients with hypothyroidism, before and after treatment with thyroxine and triiodothyronine].	Triiodothyronine	127-143	gonadotropin releasing hormone 1	Homo sapiens	33-38
199617-5	1977	This led us to study binding and actions of these metabolites in cultured rat pituitary cells in which glucose consumption and growth hormone production are regulated by T(3) and l-thyroxine.	Triiodothyronine	170-174	gonadotropin releasing hormone receptor	Rattus norvegicus	127-141
72658-6	1977	These results indicate that the euthyroid state in familial TBG deficiency is more clearly defined by TRH-test and the normal response to TRH in familial TBG deficiency is presumably under the control of the serum free T3 level rather than the serum free T4 level.	Triiodothyronine	219-221	thyrotropin releasing hormone	Homo sapiens	138-141
409288-4	1977	After treatment with triiodothyronine (T3), the elevated TSH and PRL levels fell to within normal ranges, and the galactorrhea disappeared.	Triiodothyronine	21-37	prolactin	Homo sapiens	65-68
409288-4	1977	After treatment with triiodothyronine (T3), the elevated TSH and PRL levels fell to within normal ranges, and the galactorrhea disappeared.	Triiodothyronine	39-41	prolactin	Homo sapiens	65-68
270674-3	1977	In cells maintained for 5 days in hypothyroid medium, triiodothyronine induces within 50 hr a 17-fold increase in growth hormone production whereas glucocorticoids, during the same time, produce a negligible (3-fold or less) stimulation.	Triiodothyronine	54-70	gonadotropin releasing hormone receptor	Rattus norvegicus	114-128
270674-8	1977	The results also show that triiodothyronine controls the magnitude of the effect of glucocorticoids on growth hormone mRNA, and provide a model for "permissive" triiodothyronine action.	Triiodothyronine	27-43	gonadotropin releasing hormone receptor	Rattus norvegicus	103-117
302228-0	1977	Specific inhibition of Triiodothyronine-induced tadpole tail-fin regression by cathepsin D-inhibitor pepstatin.	Triiodothyronine	23-39	cathepsin D	Homo sapiens	79-90
849733-1	1977	Addition of 3,5,3"-triiodo-L-thyronine to cultures of mammary gland explants in serumfree medium containing insulin, hydrocortisone and prolactin results in a 3 to 5-fold increase in the activity of the milk-protein alpha-lactalbumin over that seen in the presence of the latter three hormones alone.	Triiodothyronine	12-38	lactalbumin, alpha	Mus musculus	216-233
577211-0	1977	Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves" disease.	Triiodothyronine	0-16	thyroglobulin	Homo sapiens	52-65
849733-8	1977	In the presence of 10-9M triiodothyronine, enhanced alpha-lactalbumin activity is consistently obtained at prolactin concentrations as low as 4.5 x 10(-12)M whereas, in the absence of the thyroid hormone, ten times more prolactin (4.5 x 10(-11)M) is needed to obtain an increase in alpha-lactalbumin activity.	Triiodothyronine	25-41	lactalbumin, alpha	Mus musculus	52-69
849733-8	1977	In the presence of 10-9M triiodothyronine, enhanced alpha-lactalbumin activity is consistently obtained at prolactin concentrations as low as 4.5 x 10(-12)M whereas, in the absence of the thyroid hormone, ten times more prolactin (4.5 x 10(-11)M) is needed to obtain an increase in alpha-lactalbumin activity.	Triiodothyronine	25-41	lactalbumin, alpha	Mus musculus	282-299
266704-3	1977	Triiodothyronine (10 nM) and dexamethasone (1 micron) stimulated increases in growth hormone production by 2.5- and 3.8-fold, respectively.	Triiodothyronine	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	78-92
192708-5	1977	The diiodothyronine content of liothyronine sodium is estimated by liquid chromatography on a Bondapak C18 column with 0.01N sodium perchloratebutanol-acetonitrile (1000 +62 + 188) as the eluting solvent.	Triiodothyronine	31-50	Bardet-Biedl syndrome 9	Homo sapiens	103-106
192733-8	1977	After 2-3 days in culture with serum-free medium containing insulin +/- triiodothyronine, fatty acid synthesis is restored to normal; glucagon or dibutyryl cAMP blocks this recovery.	Triiodothyronine	72-88	insulin	Gallus gallus	60-67
266726-0	1977	Triiodothyronine stimulates specifically growth hormone mRNA in rat pituitary tumor cells.	Triiodothyronine	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	41-55
402243-7	1977	The results indicate that the total triiodothyronine concentration can be normalized on the basis of the triiodothyronine uptake by talc to correct for variations in thyroxine-binding globulin concentration.	Triiodothyronine	36-52	serpin family A member 7	Homo sapiens	166-192
321458-6	1977	On the other hand, when added with AIA, insulin, insulin plus hydrocortisone, insulin plus hydrocortisone triiodothyronine increased ALA synthase levels 17-, 50-, 110-fold, respectively.	Triiodothyronine	106-122	5'-aminolevulinate synthase 1	Gallus gallus	133-145
321458-7	1977	The maximally induced levels of ALA synthase activity by AIA in the presence of insulin, hydrocortisone, and triiodothyronine were approximately 15 nmol of ALA/mg of protein/h, 37 degrees or 3 micronmol of ALA/g of tissue/h, 37 degrees, a value similar to that found in ovo or at least 5 times greater than that found in rat liver.	Triiodothyronine	109-125	5'-aminolevulinate synthase 1	Gallus gallus	32-44
321458-10	1977	These data demonstrate a "permissive" effect of insulin, hydrocortisone, and triiodothyronine on the induction of ALA synthase and porphyrins by AIA in cultured chick embryo liver cells.	Triiodothyronine	77-93	5'-aminolevulinate synthase 1	Gallus gallus	114-126
837887-1	1977	Protein kinase activities were determined in liver from normal, thyroidectomized and triiodothyronine (T3)-treated rats.	Triiodothyronine	85-101	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	0-14
837887-1	1977	Protein kinase activities were determined in liver from normal, thyroidectomized and triiodothyronine (T3)-treated rats.	Triiodothyronine	103-105	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	0-14
405301-0	1977	TBG-dependency of age related variations of thyroxine and triiodothyronine.	Triiodothyronine	58-74	serpin family A member 7	Homo sapiens	0-3
197800-0	1977	Effects of dexamethasone, desoxycorticosterone, and ACTH on serum concentrations of thyroxine, 3,5,3"-triiodothyronine and 3,3",5"-triiodothyronine.	Triiodothyronine	95-118	proopiomelanocortin	Homo sapiens	52-56
401694-7	1977	There was a significant negative correlation between thyroxine-binding globulin concentration and triiodothyronine uptake in the heated serum samples and in euthyroid subjects.	Triiodothyronine	98-114	serpin family A member 7	Homo sapiens	53-79
197800-0	1977	Effects of dexamethasone, desoxycorticosterone, and ACTH on serum concentrations of thyroxine, 3,5,3"-triiodothyronine and 3,3",5"-triiodothyronine.	Triiodothyronine	123-147	proopiomelanocortin	Homo sapiens	52-56
30731569-8	1977	Thyroxine and triiodothyronine are present in human milk but practically undetectable in cow"s milk.	Triiodothyronine	14-30	Weaning weight-maternal milk	Bos taurus	52-56
401825-0	1977	Effect of triiodothyronine treatment on prolactin secretion in patients with amenorrhea-galactorrhea.	Triiodothyronine	10-26	prolactin	Homo sapiens	40-49
826546-4	1976	The TSH response to thyrotropin releasing hormone (TRH) carried out after a year of therapy and while on 0.15 mg T4 was exaggerated and required 100 mug of triiodothyronine (T3) daily in addition to the thyroxine replacement to suppress it.	Triiodothyronine	156-172	thyrotropin releasing hormone	Homo sapiens	20-49
826546-4	1976	The TSH response to thyrotropin releasing hormone (TRH) carried out after a year of therapy and while on 0.15 mg T4 was exaggerated and required 100 mug of triiodothyronine (T3) daily in addition to the thyroxine replacement to suppress it.	Triiodothyronine	156-172	thyrotropin releasing hormone	Homo sapiens	51-54
826546-4	1976	The TSH response to thyrotropin releasing hormone (TRH) carried out after a year of therapy and while on 0.15 mg T4 was exaggerated and required 100 mug of triiodothyronine (T3) daily in addition to the thyroxine replacement to suppress it.	Triiodothyronine	174-176	thyrotropin releasing hormone	Homo sapiens	20-49
826546-4	1976	The TSH response to thyrotropin releasing hormone (TRH) carried out after a year of therapy and while on 0.15 mg T4 was exaggerated and required 100 mug of triiodothyronine (T3) daily in addition to the thyroxine replacement to suppress it.	Triiodothyronine	174-176	thyrotropin releasing hormone	Homo sapiens	51-54
825796-5	1976	After treatment with L-tri-iodothyronine, serum TSH and prolactin levels fell markedly, reserves of growth hormone and ACTH returned to normal, menstrual periods began, and the patient conceived.	Triiodothyronine	21-40	proopiomelanocortin	Homo sapiens	119-123
828726-3	1976	This activity of TRH appeared to be a direct affect on CNS structures since neither triiodothyronine nor any of the constituent amino acids of TRH antagonized aggression in isolated mice.	Triiodothyronine	84-100	thyrotropin releasing hormone	Mus musculus	17-20
827396-5	1976	However, despite a seven fold increase in the overall TSH response, the T4 and T3 responses to 20 mg TRF were not significantly greater than those to 0-5 mg TRF.	Triiodothyronine	79-81	thyrotropin releasing hormone	Homo sapiens	101-104
186776-1	1976	The relationship between the binding of L-triiodothyronine (T3) to nuclear receptors and the induction of growth hormone synthesis was examined in cultured GH1 cells, a rat pituitary cell line.	Triiodothyronine	40-58	gonadotropin releasing hormone receptor	Rattus norvegicus	106-120
186776-1	1976	The relationship between the binding of L-triiodothyronine (T3) to nuclear receptors and the induction of growth hormone synthesis was examined in cultured GH1 cells, a rat pituitary cell line.	Triiodothyronine	60-62	gonadotropin releasing hormone receptor	Rattus norvegicus	106-120
821960-6	1976	Peak and net 2 h secretion responses of TSH to TRH exhibited a significant inverse correlation with the levels of serum thyroxine and serum triiodothyronine, but were unrelated to the degree of thyroid suppressibility.	Triiodothyronine	140-156	thyrotropin releasing hormone	Homo sapiens	47-50
185609-3	1976	L-Triiodothyronine stimulated synthetic rates of growth hormone by 1.5-fold in 1.25 hr, 2-fold in 2.5 hr, to a maximal of 3- to 4-fold after 8.5 hr of incubation.	Triiodothyronine	0-18	gonadotropin releasing hormone receptor	Rattus norvegicus	49-63
185609-4	1976	The time interval between significant L-triiodothyronine binding to putative nuclear receptors and a detectable increase in growth hormone synthesis was 45-60 min.	Triiodothyronine	38-56	gonadotropin releasing hormone receptor	Rattus norvegicus	124-138
185609-5	1976	Studies on the effect of actinomycin D, 3"-deoxyadenosine, and cycloheximide support the thesis that L-triiodothyronine induces the accumulation of an RNA species which is rate limiting for growth hormone synthesis and lends further support for a primary action of thyroid hormone at the nuclear level.	Triiodothyronine	101-119	gonadotropin releasing hormone receptor	Rattus norvegicus	190-204
954676-0	1976	Influence of superoxide dismutase and catalase on the stimulation by phagocytosis of L-thyroxine and L-triiodothyronine deiodination in the human leukocyte.	Triiodothyronine	101-119	catalase	Homo sapiens	38-46
185046-1	1976	Single pharmacological doses of parathyroid hormone, calcitonin, vasopressin, d-aldosterone, or L-triiodothyronine produced a significant increase in the ornithine decarboxylase activity of rat kidney.	Triiodothyronine	96-114	ornithine decarboxylase 1	Rattus norvegicus	154-177
185046-5	1976	The maximal stimulation of kidney ornithine decarboxylase activity by parathyroid hormone, calcitonin, vasopressin, L-triiodothyronine, pentagastrin, and serotonin occurred at 4 h after the hormone injection.	Triiodothyronine	116-134	ornithine decarboxylase 1	Rattus norvegicus	34-57
828576-6	1976	These results indicate that the euthyroid state in familial TBG deficiency is more clearly defined by TRH-test and the normal response to TRH in familial TBG deficiency is presumably under the control of the serum free T3 level rather than the serum free T4 level.	Triiodothyronine	219-221	thyrotropin releasing hormone	Homo sapiens	138-141
6458-1	1976	Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin.	Triiodothyronine	29-45	serpin family A member 7	Homo sapiens	57-83
186817-1	1976	Temporary suppression of rats" bar pressing, activity, and feeding by the dopamine beta-hydroxylase inhibitor FLA-63 was synergistically potentiated by triiodothyronine (T3) treatment.	Triiodothyronine	152-168	dopamine beta-hydroxylase	Rattus norvegicus	74-99
186817-1	1976	Temporary suppression of rats" bar pressing, activity, and feeding by the dopamine beta-hydroxylase inhibitor FLA-63 was synergistically potentiated by triiodothyronine (T3) treatment.	Triiodothyronine	170-172	dopamine beta-hydroxylase	Rattus norvegicus	74-99
6458-2	1976	The effect of temperature on the binding of thyroxine and triiodothyronine to thyroxine-binding globulin has been studied by equilibrium dialysis.	Triiodothyronine	58-74	serpin family A member 7	Homo sapiens	78-104
6458-6	1976	Scatchard plots of the binding data for triiodothyronine indicated that the binding of this compound to thyroxine-binding globulin was more complex than that found for thyroxine.	Triiodothyronine	40-56	serpin family A member 7	Homo sapiens	104-130
820069-0	1976	[Triiodothyronine and thyroxine in the blood of patients with thyroid diseases after oral administration of thyrotropin releasing hormone (TRH)].	Triiodothyronine	1-17	thyrotropin releasing hormone	Homo sapiens	108-137
944696-7	1976	In cells preincubated for 2 days with insulin, synthesis of malic enzyme was stimulated 4.5-fold within 3 hours after adding triiodothyronine and reached an apparent new steady state after 24 to 30 hours.	Triiodothyronine	125-141	insulin	Gallus gallus	38-45
820069-0	1976	[Triiodothyronine and thyroxine in the blood of patients with thyroid diseases after oral administration of thyrotropin releasing hormone (TRH)].	Triiodothyronine	1-17	thyrotropin releasing hormone	Homo sapiens	139-142
815889-4	1976	On the other hand substitution of thyroid hormones--thyroxine or triiodothyronine or both combined--resulted in normal levels of TSH and normal response to TRH.	Triiodothyronine	65-81	thyrotropin releasing hormone	Homo sapiens	156-159
175094-3	1976	In the rat both L-thyroxine (T4) and 3,5,3"-L-triiodothyronine (T3) pretreatment inhibited TSH-induced thyroidal ornithine decarboxylase (ODC) activity in vivo in a dose-related manner (half-maximal inhibition, 1.7 mug/rat and 0.6 mug/rat, respectively).	Triiodothyronine	64-66	ornithine decarboxylase 1	Rattus norvegicus	113-136
175094-3	1976	In the rat both L-thyroxine (T4) and 3,5,3"-L-triiodothyronine (T3) pretreatment inhibited TSH-induced thyroidal ornithine decarboxylase (ODC) activity in vivo in a dose-related manner (half-maximal inhibition, 1.7 mug/rat and 0.6 mug/rat, respectively).	Triiodothyronine	64-66	ornithine decarboxylase 1	Rattus norvegicus	138-141
816766-0	1976	Inhibition of ovine prolactin and thyrotropin responses to thyrotropin-releasing hormone by triiodothyronine.	Triiodothyronine	92-108	thyrotropin releasing hormone	Homo sapiens	59-88
829463-0	1976	[Serum and triiodothyronine following the administration of thyrotropin releasing hormone (TRH)].	Triiodothyronine	11-27	thyrotropin releasing hormone	Homo sapiens	60-89
1248450-0	1976	Conversion of L-thyroxine to triiodo-L-thyronine and biological activity of L-thyroxine, as measured by changes in growth hormone.	Triiodothyronine	29-48	gonadotropin releasing hormone receptor	Rattus norvegicus	115-129
1248450-2	1976	Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (0.2 mug/100g BW).	Triiodothyronine	131-147	gonadotropin releasing hormone receptor	Rattus norvegicus	26-28
1248450-2	1976	Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (0.2 mug/100g BW).	Triiodothyronine	149-151	gonadotropin releasing hormone receptor	Rattus norvegicus	26-28
829463-0	1976	[Serum and triiodothyronine following the administration of thyrotropin releasing hormone (TRH)].	Triiodothyronine	11-27	thyrotropin releasing hormone	Homo sapiens	91-94
1159077-4	1975	After thyrotropin-releasing hormone (TRH), there was a marked increase in TSH and secondarily in triiodothyronine (T3), the latter observation confirming the biologic activity of the TSH.	Triiodothyronine	97-113	thyrotropin releasing hormone	Homo sapiens	6-35
811471-0	1975	The response of thyrotropin and triiodothyronine to various doses of thyrotropin releasing hormone in normal man.	Triiodothyronine	32-48	thyrotropin releasing hormone	Homo sapiens	69-98
1204749-3	1975	This experiment demonstrates that two analogues of thyroid hormone, triiodothyropropionic acid and triiodothyroacetic acid, which are relatively very weak in their calorigenic action, are as potent as thyroxine and triiodothyronine in inhibiting the prolactin-mediated mammary growth in thyroidectomized rats.	Triiodothyronine	215-231	prolactin	Rattus norvegicus	250-259
810548-1	1975	An estimate of the serum thyroxine-binding globulin (TBG) may be computed from determinations of serum thyroxine and triiodothyronine uptake.	Triiodothyronine	117-133	serpin family A member 7	Homo sapiens	25-51
810548-1	1975	An estimate of the serum thyroxine-binding globulin (TBG) may be computed from determinations of serum thyroxine and triiodothyronine uptake.	Triiodothyronine	117-133	serpin family A member 7	Homo sapiens	53-56
1159077-4	1975	After thyrotropin-releasing hormone (TRH), there was a marked increase in TSH and secondarily in triiodothyronine (T3), the latter observation confirming the biologic activity of the TSH.	Triiodothyronine	97-113	thyrotropin releasing hormone	Homo sapiens	37-40
1159077-4	1975	After thyrotropin-releasing hormone (TRH), there was a marked increase in TSH and secondarily in triiodothyronine (T3), the latter observation confirming the biologic activity of the TSH.	Triiodothyronine	115-117	thyrotropin releasing hormone	Homo sapiens	6-35
1159077-4	1975	After thyrotropin-releasing hormone (TRH), there was a marked increase in TSH and secondarily in triiodothyronine (T3), the latter observation confirming the biologic activity of the TSH.	Triiodothyronine	115-117	thyrotropin releasing hormone	Homo sapiens	37-40
49266-0	1975	Rapid effects of single small doses of L-thyroxine and triiodo-L-thyronine on growth hormone, as studied in the rat by radioimmunoassy.	Triiodothyronine	55-74	gonadotropin releasing hormone receptor	Rattus norvegicus	78-92
1201005-0	1975	The early enhancement of rat liver deoxyribonucleic acid-dependent ribonucleic acid polymerase II activity by tri-iodothyronine.	Triiodothyronine	110-127	RNA polymerase II, I and III subunit F	Rattus norvegicus	84-97
803298-0	1975	Pituitary-thyroid responsiveness to intramuscular thyrotropin-releasing hormone based on analyses of serum thyroxine, tri-iodothyronine and thyrotropin concentrations.	Triiodothyronine	118-135	thyrotropin releasing hormone	Homo sapiens	50-79
1201005-1	1975	It is shown that tri-iodothyronine injected intravenously into thyroidectomized rats induces an early and transient activation of rat liver RNA polymerase II which could be demonstrated to occur 40-80 min after hormonal treatment.	Triiodothyronine	17-34	RNA polymerase II, I and III subunit F	Rattus norvegicus	144-157
819255-9	1975	Serum levels of thyroxine and triiodothyronine inversely correlated with basal, maximal TSH levels (p less than 0.01) and increment of TSH (delta TSH) after TRH injection (p less than 0.01).	Triiodothyronine	30-46	thyrotropin releasing hormone	Homo sapiens	157-160
805338-0	1975	The time course of changes in TRH responsiveness in man following a single dose of liothyronine.	Triiodothyronine	83-95	thyrotropin releasing hormone	Homo sapiens	30-33
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	75-87	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	75-87	thyrotropin releasing hormone	Homo sapiens	50-53
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	118-134	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	118-134	thyrotropin releasing hormone	Homo sapiens	50-53
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	136-138	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	136-138	thyrotropin releasing hormone	Homo sapiens	50-53
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	50-53
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	50-53
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	20-23
805338-3	1975	The TSH response to TRH was mildly depressed when TRH was given 1 hr after liothyronine administration when the serum triiodothyronine (T3) concentration was strikingly elevated, was markedly reduced 16 and 24 hr after liothyronine, was essentially abolished 3 days after liothyronine when the serum T3 concentration was normal, and was normal 7 days after liothyronine administration.	Triiodothyronine	219-231	thyrotropin releasing hormone	Homo sapiens	50-53
1173052-1	1975	Erythrocytes are hemolyzed by myeloperoxidase, an H2O2-generating system (glucose + glucose oxidase; hypoxanthine + xanthine oxidase) and an oxidizable cofactor (chloride, iodide, thyroxine, triiodothyronine).	Triiodothyronine	191-207	myeloperoxidase	Homo sapiens	30-45
1173052-3	1975	Myeloperoxidase can be replaced by lactoperoxidase in the iodide-, thyroxine and triiodothyronine-dependent, but not in the chloride-dependent, systems.	Triiodothyronine	81-97	myeloperoxidase	Homo sapiens	0-15
1141804-1	1975	Thyroxine (T-4) and tri-iodothyronine (T-3) were coupled to human serum albumin (HSA) with carbodi-imide.	Triiodothyronine	20-37	albumin	Oryctolagus cuniculus	66-79
1141804-1	1975	Thyroxine (T-4) and tri-iodothyronine (T-3) were coupled to human serum albumin (HSA) with carbodi-imide.	Triiodothyronine	39-42	albumin	Oryctolagus cuniculus	66-79
50954-0	1975	[Relation of TRH test to thyroidal suppression test by triiodothyronine in patients with hyperthyroidism under treatment with antithyroid drugs (author"s transl)].	Triiodothyronine	55-71	thyrotropin releasing hormone	Homo sapiens	13-16
4452347-0	1974	[Triiodothyronine binding coefficient determination as an aid in the evaluation of indications for thyroidectomy in cases of tachycardia].	Triiodothyronine	1-17	activation induced cytidine deaminase	Homo sapiens	58-61
817374-5	1975	Thyrotropin (TSH) and tri-iodothyronine (T3) were in effective, suggesting that the effects observed with TRH are not mediated via the pituitary-thyroid axis.	Triiodothyronine	41-43	thyrotropin releasing hormone	Mus musculus	106-109
4211761-2	1974	Of the various thyroid hormone derivatives tested, only 3,3"-diiodothyronine (3,3"-T(2)) cross-reacted significantly (10%) with rT(3)-binding sites on the antiserum, while thyroxine (T(4)) and triiodothyronine (T(3)) cross-reacted by less than 0.1%.	Triiodothyronine	193-209	brachyury 2	Rattus norvegicus	83-87
4218545-0	1974	The use of merthiolate for TBG-blocking in the radioimmunoassay of triiodothyronine.	Triiodothyronine	67-83	serpin family A member 7	Homo sapiens	27-30
4214837-1	1974	To determine whether pituitary thyrotropin (TSH) responsiveness to thyrotropin-releasing hormone (TRH) is enhanced by small decreases in serum thyroxine (T4) and triiodothyronine (T3), 12 euthyroid volunteers were given 190 mg iodide po daily for 10 days to inhibit T4 and T3 release from the thyroid.	Triiodothyronine	162-178	thyrotropin releasing hormone	Homo sapiens	67-96
4214837-1	1974	To determine whether pituitary thyrotropin (TSH) responsiveness to thyrotropin-releasing hormone (TRH) is enhanced by small decreases in serum thyroxine (T4) and triiodothyronine (T3), 12 euthyroid volunteers were given 190 mg iodide po daily for 10 days to inhibit T4 and T3 release from the thyroid.	Triiodothyronine	162-178	thyrotropin releasing hormone	Homo sapiens	98-101
4214837-1	1974	To determine whether pituitary thyrotropin (TSH) responsiveness to thyrotropin-releasing hormone (TRH) is enhanced by small decreases in serum thyroxine (T4) and triiodothyronine (T3), 12 euthyroid volunteers were given 190 mg iodide po daily for 10 days to inhibit T4 and T3 release from the thyroid.	Triiodothyronine	180-182	thyrotropin releasing hormone	Homo sapiens	98-101
11344581-2	1974	High-affinity, limited-capacity nuclear binding activities, putative receptors for triiodothyronine, were detected after incubation of hormone with intact rat pituitary GH1 cells in culture, isolated GH1 cell nuclei, or rat liver nuclei.	Triiodothyronine	83-99	growth hormone 1	Rattus norvegicus	169-172
4207369-0	1974	Thermal inactivation of thyroxine-binding globulin for direct radioimmunoassay of triiodothyronine in serum.	Triiodothyronine	82-98	serpin family A member 7	Homo sapiens	24-50
11344581-2	1974	High-affinity, limited-capacity nuclear binding activities, putative receptors for triiodothyronine, were detected after incubation of hormone with intact rat pituitary GH1 cells in culture, isolated GH1 cell nuclei, or rat liver nuclei.	Triiodothyronine	83-99	growth hormone 1	Rattus norvegicus	200-203
4739852-0	1973	Effects of L-triiodothyronine on insulin secretion in man.	Triiodothyronine	11-29	insulin	Homo sapiens	33-40
4199417-1	1973	Repetitive administration of thyrotropin-releasing hormone (TRH) to human subjects was used to produce small elevations of endogenous serum triiodothyronine (T(3)) and thyroxine (T(4)) levels and thereby to determine the effect of these small elevations on the serum thyrotropin (TSH) response to subsequent doses of TRH.	Triiodothyronine	140-156	thyrotropin releasing hormone	Homo sapiens	29-58
4199417-1	1973	Repetitive administration of thyrotropin-releasing hormone (TRH) to human subjects was used to produce small elevations of endogenous serum triiodothyronine (T(3)) and thyroxine (T(4)) levels and thereby to determine the effect of these small elevations on the serum thyrotropin (TSH) response to subsequent doses of TRH.	Triiodothyronine	140-156	thyrotropin releasing hormone	Homo sapiens	60-63
4196535-0	1973	A comparison of different compounds for TBG-blocking used in radioimmunoassay for tri-iodothyronine.	Triiodothyronine	82-99	serpin family A member 7	Homo sapiens	40-43
4199418-1	1973	The influence of serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations on the release of prolactin in man was studied by determining the prolactin response to synthetic thyrotropin-releasing hormone (TRH) in hypothyroid and hyperthyroid patients before and after correction of their serum thyroid hormone abnormalities.	Triiodothyronine	23-39	prolactin	Homo sapiens	101-110
4199418-1	1973	The influence of serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations on the release of prolactin in man was studied by determining the prolactin response to synthetic thyrotropin-releasing hormone (TRH) in hypothyroid and hyperthyroid patients before and after correction of their serum thyroid hormone abnormalities.	Triiodothyronine	41-45	prolactin	Homo sapiens	101-110
4714554-0	1973	Effects of L-triiodothyronine on insulin secretion in man.	Triiodothyronine	11-29	insulin	Homo sapiens	33-40
4735001-1	1973	Serum triiodothyronine (T-3) concentrations have been estimated by radioimmunoassay using unextracted serum.	Triiodothyronine	6-22	solute carrier family 25 member 5	Homo sapiens	24-27
4629908-0	1973	Modulation of pituitary responsiveness to thyrotropin-releasing hormone by triiodothyronine.	Triiodothyronine	75-91	thyrotropin releasing hormone	Homo sapiens	42-71
4629908-1	1973	The relative roles of triiodothyronine (T(3)) and thyroxine (T(4)) in modulating pituitary responsiveness to thyrotropin-releasing hormone (TRH) have been assessed.	Triiodothyronine	22-38	thyrotropin releasing hormone	Homo sapiens	109-138
4629908-1	1973	The relative roles of triiodothyronine (T(3)) and thyroxine (T(4)) in modulating pituitary responsiveness to thyrotropin-releasing hormone (TRH) have been assessed.	Triiodothyronine	22-38	thyrotropin releasing hormone	Homo sapiens	140-143
4629908-6	1973	TRH responsiveness was restored when T(3) levels fell to normal after propylthiouracil therapy.	Triiodothyronine	37-41	thyrotropin releasing hormone	Homo sapiens	0-3
4629908-7	1973	(c) When pituitary responsiveness to TRH was tested 60 min after a single oral dose of 50 mug of T(3), which increased serum T(3) levels to slightly above the normal range, no rise in thyrotropin (TSH) was seen in six subjects.	Triiodothyronine	97-101	thyrotropin releasing hormone	Homo sapiens	37-40
4629909-1	1973	Thyroxine (T(4)) and triiodothyronine (T(9)) are rapidly degraded by a purified preparation of myeloperoxidase (MPO) and H(2)O(2) with the formation of iodide and material which remains at the origin on paper chromatography.	Triiodothyronine	21-37	myeloperoxidase	Homo sapiens	95-110
4629909-1	1973	Thyroxine (T(4)) and triiodothyronine (T(9)) are rapidly degraded by a purified preparation of myeloperoxidase (MPO) and H(2)O(2) with the formation of iodide and material which remains at the origin on paper chromatography.	Triiodothyronine	21-37	myeloperoxidase	Homo sapiens	112-115
4627755-0	1972	Thyroxine-binding globulin: specificity for the hormonally active conformation of triiodothyronine.	Triiodothyronine	82-98	serpin family A member 7	Homo sapiens	0-26
4627755-1	1972	The conformational requirements for binding of triiodothyronine to thyroxine-binding globulin were investigated with triiodothyronine analogs having restricted rotation at the ether bond.	Triiodothyronine	47-63	serpin family A member 7	Homo sapiens	67-93
4627755-2	1972	Although it has been reported that the predominant conformation of triiodothyronine carries the 3" iodine in a position proximal to the phenylalanine ring, the analog for the distal, hormonally active orientation of the 3" iodine is more effective in displacing triiodothyronine and thyroxine from thyroxine-binding globulin.	Triiodothyronine	67-83	serpin family A member 7	Homo sapiens	298-324
4627755-3	1972	The lower binding affinity of thyroxine-binding globulin for triiodothyronine as compared to thyroxine may be explained by specificity of the binding site for the less abundant conformation of triiodothyronine.	Triiodothyronine	61-77	serpin family A member 7	Homo sapiens	30-56
4627755-3	1972	The lower binding affinity of thyroxine-binding globulin for triiodothyronine as compared to thyroxine may be explained by specificity of the binding site for the less abundant conformation of triiodothyronine.	Triiodothyronine	193-209	serpin family A member 7	Homo sapiens	30-56
4111366-7	1972	QUANTITATIVE VARIATION IN THE SERUM CONCENTRATION OF FUNCTIONALLY NORMAL TBG WAS DEMONSTRATED BY: (a) failure of serum from TBG-deficient subjects to react with anti-TBG antibodies; (b) normal kinetics of T(4) and triiodothyronine-binding to TBG in sera from subjects with low TBG and high TBG capacity; (c) concordance of estimates of TBG concentration by T(4) saturation and by immunological methods; and (d) normal rate of heat inactivation of TBG.	Triiodothyronine	214-230	serpin family A member 7	Homo sapiens	73-76
4623165-1	1972	Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin.	Triiodothyronine	26-42	serpin family A member 7	Homo sapiens	54-80
4623165-4	1972	Using ultrafiltration techniques, we demonstrated binding of T(3) to TBPA.	Triiodothyronine	61-65	transthyretin	Homo sapiens	69-73
4623165-5	1972	The affinity constant for T(3)-TBPA binding appears to be slightly greater than that for albumin-T(3) binding.	Triiodothyronine	26-30	transthyretin	Homo sapiens	31-35
4623165-7	1972	Using a competitive-binding protein displacement technique, it has been shown that sodium salicylate, like diphenylhydantoin (DPH), inhibits the binding of T(3) and T(4) to TBG.	Triiodothyronine	156-160	serpin family A member 7	Homo sapiens	173-176
4626581-1	1972	A sensitive and precise radioimmunoassay for the direct measurement of triiodothyronine (T(3)) in human serum has been designed using sodium salicylate to block T(3)-TBG binding.	Triiodothyronine	71-87	serpin family A member 7	Homo sapiens	166-169
4626581-1	1972	A sensitive and precise radioimmunoassay for the direct measurement of triiodothyronine (T(3)) in human serum has been designed using sodium salicylate to block T(3)-TBG binding.	Triiodothyronine	89-93	serpin family A member 7	Homo sapiens	166-169
4626581-1	1972	A sensitive and precise radioimmunoassay for the direct measurement of triiodothyronine (T(3)) in human serum has been designed using sodium salicylate to block T(3)-TBG binding.	Triiodothyronine	161-165	serpin family A member 7	Homo sapiens	166-169
4626582-1	1972	Inhibition of thyrotropin (TSH) release by chronic treatment with small quantities of triiodothyronine (T(3)) and thyroxine (T(4)) was evaluated by determining the serum TSH response to thyrotropin-releasing hormone (TRH) in normal subjects and hypothyroid patients.	Triiodothyronine	86-102	thyrotropin releasing hormone	Homo sapiens	186-215
4626582-1	1972	Inhibition of thyrotropin (TSH) release by chronic treatment with small quantities of triiodothyronine (T(3)) and thyroxine (T(4)) was evaluated by determining the serum TSH response to thyrotropin-releasing hormone (TRH) in normal subjects and hypothyroid patients.	Triiodothyronine	86-102	thyrotropin releasing hormone	Homo sapiens	217-220
4626583-13	1972	When the concentrations of thyroxine (T4) and triiodothyronine (T3) are low, the levels of HPr before and after TRH are elevated.	Triiodothyronine	46-62	haptoglobin-related protein	Homo sapiens	91-94
4626583-13	1972	When the concentrations of thyroxine (T4) and triiodothyronine (T3) are low, the levels of HPr before and after TRH are elevated.	Triiodothyronine	64-66	haptoglobin-related protein	Homo sapiens	91-94
4621482-1	1972	Administration of thyrotropin-releasing hormone to normal subjects causes a prompt rise in plasma thyrotropin concentration, followed by a significant increase in circulating plasma triiodothyronine.	Triiodothyronine	182-198	thyrotropin releasing hormone	Homo sapiens	18-47
4110898-1	1972	Electrophoretic studies of triiodothyronine-TBPA interaction.	Triiodothyronine	27-43	transthyretin	Homo sapiens	44-48
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	166-182	transthyretin	Homo sapiens	0-28
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	166-182	transthyretin	Homo sapiens	30-34
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	184-186	transthyretin	Homo sapiens	0-28
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	184-186	transthyretin	Homo sapiens	30-34
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	210-212	transthyretin	Homo sapiens	0-28
4110898-2	1972	Thyroxine-binding prealbumin (TBPA) in normal human serum has been shown in a polyacrylamide gel electrophoresis system to bind 7-9% of tracer level purified [(125)I]triiodothyronine (T3), and more than 30% of T3 in serum deficient in thyroxinebinding globulin (TBG).	Triiodothyronine	210-212	transthyretin	Homo sapiens	30-34
4110898-3	1972	The T3-TBPA interaction has been confirmed at pH 9.0 and pH 7.4 in this electrophoretic demonstration of TBPA binding of T3 in serum.	Triiodothyronine	4-6	transthyretin	Homo sapiens	7-11
4110898-3	1972	The T3-TBPA interaction has been confirmed at pH 9.0 and pH 7.4 in this electrophoretic demonstration of TBPA binding of T3 in serum.	Triiodothyronine	4-6	transthyretin	Homo sapiens	105-109
5002270-0	1971	Alterations in thyroxine (T 4 ) and tri-iodothyronine (T 3 ) binding to serum proteins by heat.	Triiodothyronine	36-53	solute carrier family 25 member 5	Homo sapiens	55-58
5007046-1	1972	Highly specific antisera to triiodothyronine (T(3)) were prepared by immunization of rabbits with T(3)-bovine serum albumin conjugates.	Triiodothyronine	28-44	solute carrier family 25 member 5	Homo sapiens	46-50
5007046-1	1972	Highly specific antisera to triiodothyronine (T(3)) were prepared by immunization of rabbits with T(3)-bovine serum albumin conjugates.	Triiodothyronine	28-44	solute carrier family 25 member 5	Homo sapiens	98-102
5007046-14	1972	Triiodothyronine (T(3))(1) was recognized to be a biologically active secretory product of the thyroid gland over a decade ago (1).	Triiodothyronine	0-16	solute carrier family 25 member 5	Homo sapiens	18-22
4998976-0	1971	Radioimmunoassay for triiodothyronine (T 3 ): I. Affinity and specificity of the antibody for T 3 .	Triiodothyronine	21-37	solute carrier family 25 member 5	Homo sapiens	39-42
5007046-20	1972	Several preliminary reports have appeared describing the preparation of antibody to triiodothyronine by immunization of animals with T(3)-protein conjugates and its use for the measurement of T(3) in serum (12-15).	Triiodothyronine	84-100	solute carrier family 25 member 5	Homo sapiens	133-137
5007046-20	1972	Several preliminary reports have appeared describing the preparation of antibody to triiodothyronine by immunization of animals with T(3)-protein conjugates and its use for the measurement of T(3) in serum (12-15).	Triiodothyronine	84-100	solute carrier family 25 member 5	Homo sapiens	192-196
5317263-0	1971	Effects of thyroidectomy and triiodothyronine (T 3 ) on the synthesis and release of growth hormone (GH) and prolactin.	Triiodothyronine	29-45	growth hormone 1	Homo sapiens	85-99
5317263-0	1971	Effects of thyroidectomy and triiodothyronine (T 3 ) on the synthesis and release of growth hormone (GH) and prolactin.	Triiodothyronine	29-45	growth hormone 1	Homo sapiens	101-103
4107265-3	1971	The assay is set up in the presence of 250 ng thyroxine (T(4)) in all tubes, to mobilize T(3) from its binding with the thyronine-binding globulin (TBG), and athyreotic sheep serum in standards to correct for the TBG in the unknowns.	Triiodothyronine	89-93	serpin family A member 7	Homo sapiens	120-146
4107265-3	1971	The assay is set up in the presence of 250 ng thyroxine (T(4)) in all tubes, to mobilize T(3) from its binding with the thyronine-binding globulin (TBG), and athyreotic sheep serum in standards to correct for the TBG in the unknowns.	Triiodothyronine	89-93	serpin family A member 7	Homo sapiens	148-151
4998976-0	1971	Radioimmunoassay for triiodothyronine (T 3 ): I. Affinity and specificity of the antibody for T 3 .	Triiodothyronine	21-37	solute carrier family 25 member 5	Homo sapiens	94-97
5569904-2	1971	Glutamine synthetase development in the retina and liver of the normal and triiodothyronine-treated rat.	Triiodothyronine	75-91	glutamate-ammonia ligase	Rattus norvegicus	0-20
5155918-0	1971	[Behavior of thyrotropic hormone (TSH), triiodothyronine (T3) and thyroxine (T4) following administration of thyrotropin releasing hormone (TRH) in persons with sound metabolism].	Triiodothyronine	40-56	thyrotropin releasing hormone	Homo sapiens	140-143
5155918-0	1971	[Behavior of thyrotropic hormone (TSH), triiodothyronine (T3) and thyroxine (T4) following administration of thyrotropin releasing hormone (TRH) in persons with sound metabolism].	Triiodothyronine	58-60	thyrotropin releasing hormone	Homo sapiens	109-138
4986213-7	1970	However, it is suggested that the effects of alterations in the T(3)-TBG binding interaction on the metabolism of T(3) are obscured by alterations in the extracellular-cellular partitioning of T(4) that would result from concurrent alterations in T(4)-binding by TBG.	Triiodothyronine	64-68	serpin family A member 7	Homo sapiens	69-72
4986213-7	1970	However, it is suggested that the effects of alterations in the T(3)-TBG binding interaction on the metabolism of T(3) are obscured by alterations in the extracellular-cellular partitioning of T(4) that would result from concurrent alterations in T(4)-binding by TBG.	Triiodothyronine	114-118	serpin family A member 7	Homo sapiens	69-72
4972270-0	1968	Effect of sulfonylurea drugs on the binding of triiodothyronine and thyroxine to thyroxine-binding globulin.	Triiodothyronine	47-63	serpin family A member 7	Homo sapiens	81-107
4982214-0	1969	Triiodothyronine binding affinity for thyroxine-binding globulin in serum from normal subjects and from hyperthyroid, hypothyroid and pregnant patients.	Triiodothyronine	0-16	serpin family A member 7	Homo sapiens	38-64
5783581-0	1969	Effect of triiodothyronine administration on serum PBI in hypothyroid patients maintained on constant doses of thyroxine.	Triiodothyronine	10-26	submaxillary gland androgen regulated protein 3A	Homo sapiens	51-54
5304832-0	1969	Effects of triiodothyronine-induced hypermetabolism on factor 8 and fibrinogen in man.	Triiodothyronine	11-27	fibrinogen beta chain	Homo sapiens	68-78
5304832-6	1969	Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen.	Triiodothyronine	0-16	fibrinogen beta chain	Homo sapiens	108-118
4964565-2	1967	Myeloperoxidase can be replaced in this system by lactoperoxidase or by a guinea pig leukocyte particulate preparation, H(2)O(2) by an H(2)O(2)-generating system such as glucose and glucose oxidase, and iodide by thyroxine or triiodothyronine.	Triiodothyronine	226-242	myeloperoxidase	Cavia porcellus	0-15
4172459-3	1968	In addition, a smaller than normal proportion of (131)I-labeled T(3) was associated with TBG during filter paper electrophoresis.	Triiodothyronine	64-68	serpin family A member 7	Homo sapiens	89-92
13869633-1	1961	Treatment with thyroxine or liothyronine increased the urinary excretion of free histamine in male and female rats under the influence of aminoguanidine, a histaminase inhibitor.	Triiodothyronine	28-40	amine oxidase, copper containing 1	Rattus norvegicus	156-167
13803714-3	1959	Because it had been previously observed that ACTH or cortisone markedly accelerated the multiplication of brucellae in the livers of infected mice with destruction of liver cells, it was considered that triiodothyronine might likewise exaggerate a brucella infection by stimulating endogenous adrenal secretion.	Triiodothyronine	203-219	pro-opiomelanocortin-alpha	Mus musculus	45-49
13886068-0	1961	[Data on the behavior of bilirubinemia and the erythrocytic glucose-6-phosphate dehydrogenase activity in full-term newborn infants treated with triiodothyronine].	Triiodothyronine	145-161	glucose-6-phosphate dehydrogenase	Homo sapiens	60-93
13672147-0	1959	Metabolism of monoiodotyrosine, diiodotyrosine, triiodothyronine and thyroxine by L-amino acid oxidase.	Triiodothyronine	48-64	interleukin 4 induced 1	Homo sapiens	82-102
13334595-0	1956	[Effect of thyroxin and triiodothyronine on the activity of amine oxydase and DOPA decarboxylase in liver].	Triiodothyronine	24-40	dopa decarboxylase	Homo sapiens	78-96
33345322-6	2021	T3 rapidly activates extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, which was partially inhibited by AT1R blockade.	Triiodothyronine	0-2	mitogen-activated protein kinase 1	Homo sapiens	21-62
33345322-6	2021	T3 rapidly activates extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, which was partially inhibited by AT1R blockade.	Triiodothyronine	0-2	mitogen-activated protein kinase 3	Homo sapiens	64-70
33345322-6	2021	T3 rapidly activates extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, which was partially inhibited by AT1R blockade.	Triiodothyronine	0-2	angiotensin II receptor type 1	Homo sapiens	116-120
33345322-7	2021	Also, ERK1/2 inhibition attenuated the hypertrophic effects of T3.	Triiodothyronine	63-65	mitogen-activated protein kinase 3	Homo sapiens	6-12
33936274-10	2021	The L1, 25-(OH)D3 and IL-2 levels were significantly negatively correlated with thyroid function index and free triiodothyronine (FT3) while a statistically positive correlation was found between IL-6 and FT3 (P<0.05).	Triiodothyronine	112-128	interleukin 2	Homo sapiens	22-26
33345322-12	2021	Our results evidence the contribution of ARRB2 on ERK1/2 activation and cardiomyocyte hypertrophy induced by T3 via AT1R.	Triiodothyronine	109-111	arrestin beta 2	Homo sapiens	41-46
33345322-12	2021	Our results evidence the contribution of ARRB2 on ERK1/2 activation and cardiomyocyte hypertrophy induced by T3 via AT1R.	Triiodothyronine	109-111	angiotensin II receptor type 1	Homo sapiens	116-120
33980776-0	2021	Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.	Triiodothyronine	5-21	insulin	Homo sapiens	134-141
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Triiodothyronine	192-208	interleukin 1 alpha	Homo sapiens	68-77
34047515-2	2021	The aim of the research is to analyze the correlation between serum IL-1alpha concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program.	Triiodothyronine	210-212	interleukin 1 alpha	Homo sapiens	68-77
33999131-15	2021	Inhibition of either eNOS or PI3K reduced T3-mediated vasodilation from 52.7+-4.5% NE to 28.5+-4.1% NE and 22.7+-2.9% NE, respectively.	Triiodothyronine	42-44	nitric oxide synthase 3, endothelial cell	Mus musculus	21-25
33980776-1	2021	Free triiodothyronine/free thyroxine (FT3/FT4) ratio is considered as an index of the activities of iodothyronine deiodinase types 1 and 2 (DIO1 and DIO2, respectively) and is reportedly associated with insulin resistance in euthyroid adults.	Triiodothyronine	5-21	iodothyronine deiodinase 1	Homo sapiens	100-138
33980776-1	2021	Free triiodothyronine/free thyroxine (FT3/FT4) ratio is considered as an index of the activities of iodothyronine deiodinase types 1 and 2 (DIO1 and DIO2, respectively) and is reportedly associated with insulin resistance in euthyroid adults.	Triiodothyronine	5-21	iodothyronine deiodinase 1	Homo sapiens	140-144
33980776-1	2021	Free triiodothyronine/free thyroxine (FT3/FT4) ratio is considered as an index of the activities of iodothyronine deiodinase types 1 and 2 (DIO1 and DIO2, respectively) and is reportedly associated with insulin resistance in euthyroid adults.	Triiodothyronine	5-21	insulin	Homo sapiens	203-210
33757992-4	2021	T3-treatment of animals in vivo not only confirmed the positive action of this hormone on crypt cell proliferation but also demonstrated its key action in modulating i) the number of the stem cells, ii) the expression of their specific markers and iii) the commitment of progenitors into lineage-specific differentiation.In conclusion, T3 treatment or TRalpha1 modulation has a rapid and strong effect on intestinal stem cells, broadening our perspectives in the study of T3/TRalpha1-dependent signaling in these cells.	Triiodothyronine	0-2	detected by T cells 1	Mus musculus	352-360
33960321-1	2021	Summary: Resistance to thyroid hormone (RTH) is a rare hereditary syndrome with impaired sensitivity to thyroid hormones (TH) and reduced intracellular action of triiodothyronine (T3) caused by genetic variants of TH receptor beta (TRB) or alpha (TRA).	Triiodothyronine	180-182	T cell receptor alpha locus	Homo sapiens	247-250
33450664-6	2021	The TR ligand analogs were designed to have higher (G2) and lower (N1) binding energies than T3 when docked to the TR:RXR(9C) complex.	Triiodothyronine	93-95	coagulation factor II thrombin receptor	Homo sapiens	4-6
33450664-6	2021	The TR ligand analogs were designed to have higher (G2) and lower (N1) binding energies than T3 when docked to the TR:RXR(9C) complex.	Triiodothyronine	93-95	coagulation factor II thrombin receptor	Homo sapiens	115-121
33675223-6	2021	Notably, the expression of genes encoding to Fgf19 and its receptor Fgfr4 was markedly increased in the intestine of hypothyroid adults, and treatment with T3 normalized it.	Triiodothyronine	156-158	fibroblast growth factor 19	Danio rerio	45-50
33675223-6	2021	Notably, the expression of genes encoding to Fgf19 and its receptor Fgfr4 was markedly increased in the intestine of hypothyroid adults, and treatment with T3 normalized it.	Triiodothyronine	156-158	fibroblast growth factor receptor 4	Danio rerio	68-73
33450664-3	2021	It is regulated by the TR native ligand triiodothyronine (T3), which displays anticooperative behavior to the RXR ligand 9-cis retinoic acid (9C).	Triiodothyronine	40-56	coagulation factor II thrombin receptor	Homo sapiens	23-25
33450664-3	2021	It is regulated by the TR native ligand triiodothyronine (T3), which displays anticooperative behavior to the RXR ligand 9-cis retinoic acid (9C).	Triiodothyronine	58-60	coagulation factor II thrombin receptor	Homo sapiens	23-25
33757992-4	2021	T3-treatment of animals in vivo not only confirmed the positive action of this hormone on crypt cell proliferation but also demonstrated its key action in modulating i) the number of the stem cells, ii) the expression of their specific markers and iii) the commitment of progenitors into lineage-specific differentiation.In conclusion, T3 treatment or TRalpha1 modulation has a rapid and strong effect on intestinal stem cells, broadening our perspectives in the study of T3/TRalpha1-dependent signaling in these cells.	Triiodothyronine	0-2	detected by T cells 1	Mus musculus	475-483
33851304-0	2021	Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans.	Triiodothyronine	0-16	klotho	Mus musculus	96-102
33851544-0	2021	PINK1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-induced Lung Injury.	Triiodothyronine	57-59	PTEN induced putative kinase 1	Mus musculus	0-5
33851544-14	2021	T3 pretreatment also increased mitochondrial anti-ROS potential, improved mitochondrial bioenergetics and mitophagy, and attenuated mitochondria-regulated apoptosis, all in a PINK1-dependent manner.	Triiodothyronine	0-2	PTEN induced putative kinase 1	Mus musculus	175-180
33851304-0	2021	Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans.	Triiodothyronine	18-20	klotho	Mus musculus	96-102
33851304-6	2021	In this study, we sought to determine the regulatory role of Triiodothyronine (T3) on homologs genes of klotho and its impact on different parameters of aging in the C. elegans model organism.	Triiodothyronine	61-77	klotho	Mus musculus	104-110
33851304-6	2021	In this study, we sought to determine the regulatory role of Triiodothyronine (T3) on homologs genes of klotho and its impact on different parameters of aging in the C. elegans model organism.	Triiodothyronine	79-81	klotho	Mus musculus	104-110
33869182-7	2021	Expression levels of Period2 and nucleotide metabolism enzymes were analyzed after triiodothyronine treatment and Period2-shRNA lentivirus transduction.	Triiodothyronine	83-99	period circadian regulator 2	Homo sapiens	21-28
33440041-0	2021	Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP-PKA pathway.	Triiodothyronine	0-16	vascular endothelial growth factor A	Mus musculus	40-44
33440041-2	2021	Our group earlier showed that the stimulatory role of the thyroid hormone, T3 , on the production of vascular endothelial growth factor (VEGF) by murine Leydig cells is mediated by steroids and hypoxia-inducible factor-1 (HIF-1alpha).	Triiodothyronine	75-77	vascular endothelial growth factor A	Mus musculus	101-135
33440041-2	2021	Our group earlier showed that the stimulatory role of the thyroid hormone, T3 , on the production of vascular endothelial growth factor (VEGF) by murine Leydig cells is mediated by steroids and hypoxia-inducible factor-1 (HIF-1alpha).	Triiodothyronine	75-77	vascular endothelial growth factor A	Mus musculus	137-141
33440041-2	2021	Our group earlier showed that the stimulatory role of the thyroid hormone, T3 , on the production of vascular endothelial growth factor (VEGF) by murine Leydig cells is mediated by steroids and hypoxia-inducible factor-1 (HIF-1alpha).	Triiodothyronine	75-77	hypoxia inducible factor 1, alpha subunit	Mus musculus	222-232
33869182-8	2021	Chromatin immunoprecipitation was used to analyze the effects of triiodothyronine and thyroid hormone receptor-beta on Period2 expression.	Triiodothyronine	65-81	period circadian regulator 2	Homo sapiens	119-126
33869182-13	2021	Triiodothyronine promoted the binding of thyroid hormone receptor-beta to the Period2 promoter and subsequent transcription of Period2.	Triiodothyronine	0-16	thyroid hormone receptor beta	Homo sapiens	41-70
33869182-13	2021	Triiodothyronine promoted the binding of thyroid hormone receptor-beta to the Period2 promoter and subsequent transcription of Period2.	Triiodothyronine	0-16	period circadian clock 2	Mus musculus	78-85
33869182-13	2021	Triiodothyronine promoted the binding of thyroid hormone receptor-beta to the Period2 promoter and subsequent transcription of Period2.	Triiodothyronine	0-16	period circadian clock 2	Mus musculus	127-134
33869182-14	2021	Triiodothyronine also enhanced nuclear expression of Sirt1, which synergistically enhanced Period2 expression.	Triiodothyronine	0-16	sirtuin 1	Homo sapiens	53-58
33869182-14	2021	Triiodothyronine also enhanced nuclear expression of Sirt1, which synergistically enhanced Period2 expression.	Triiodothyronine	0-16	period circadian clock 2	Mus musculus	91-98
33869182-15	2021	The study demonstrated that triiodothyronine is independently positively correlated with serum urate and liver uric acid production through Period2, providing novel insights into the purine metabolism underlying hyperuricemia/gout pathophysiology.	Triiodothyronine	28-44	period circadian clock 2	Mus musculus	140-147
33724692-5	2021	In vitro, T3 pretreatment decreased cell apoptosis rate, inhibited caspase-3 activity and decreased the Bax/Bcl-2 ration induced by H/R injury.	Triiodothyronine	10-12	caspase 3	Mus musculus	67-76
32964425-0	2021	Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-kB.	Triiodothyronine	27-29	forkhead box O3	Rattus norvegicus	80-85
33724692-5	2021	In vitro, T3 pretreatment decreased cell apoptosis rate, inhibited caspase-3 activity and decreased the Bax/Bcl-2 ration induced by H/R injury.	Triiodothyronine	10-12	BCL2-associated X protein	Mus musculus	104-107
32964425-0	2021	Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-kB.	Triiodothyronine	27-29	superoxide dismutase 1	Rattus norvegicus	86-90
32964425-0	2021	Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-kB.	Triiodothyronine	27-29	catalase	Rattus norvegicus	91-99
33724692-5	2021	In vitro, T3 pretreatment decreased cell apoptosis rate, inhibited caspase-3 activity and decreased the Bax/Bcl-2 ration induced by H/R injury.	Triiodothyronine	10-12	B cell leukemia/lymphoma 2	Mus musculus	108-113
32964425-0	2021	Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-kB.	Triiodothyronine	27-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	119-124
33724692-8	2021	Also, T3 increased the expression of IGF-1, and PI3K/Akt signalling in cardiomyocytes under H/R-induced injury, and that the protective effect of T3 against H/R-induced injury was blocked by the PI3K inhibitor LY294002.	Triiodothyronine	6-8	insulin-like growth factor 1	Mus musculus	37-42
33724692-8	2021	Also, T3 increased the expression of IGF-1, and PI3K/Akt signalling in cardiomyocytes under H/R-induced injury, and that the protective effect of T3 against H/R-induced injury was blocked by the PI3K inhibitor LY294002.	Triiodothyronine	6-8	thymoma viral proto-oncogene 1	Mus musculus	53-56
33724692-8	2021	Also, T3 increased the expression of IGF-1, and PI3K/Akt signalling in cardiomyocytes under H/R-induced injury, and that the protective effect of T3 against H/R-induced injury was blocked by the PI3K inhibitor LY294002.	Triiodothyronine	146-148	insulin-like growth factor 1	Mus musculus	37-42
33724692-8	2021	Also, T3 increased the expression of IGF-1, and PI3K/Akt signalling in cardiomyocytes under H/R-induced injury, and that the protective effect of T3 against H/R-induced injury was blocked by the PI3K inhibitor LY294002.	Triiodothyronine	146-148	thymoma viral proto-oncogene 1	Mus musculus	53-56
33724692-10	2021	In summary, T3 pretreatment protects cardiomyocytes against H/R-induced injury by activating the IGF-1-mediated PI3K/Akt signalling pathway.	Triiodothyronine	12-14	insulin-like growth factor 1	Mus musculus	97-102
33724692-10	2021	In summary, T3 pretreatment protects cardiomyocytes against H/R-induced injury by activating the IGF-1-mediated PI3K/Akt signalling pathway.	Triiodothyronine	12-14	thymoma viral proto-oncogene 1	Mus musculus	117-120
32977740-10	2021	A decreased local T3 supply was associated with DIO3 upregulation.	Triiodothyronine	18-20	iodothyronine deiodinase 3	Homo sapiens	48-52
32977740-13	2021	DIO3 regulates the cellular supply of T3 which is essential for the cell homeostasis.	Triiodothyronine	38-40	iodothyronine deiodinase 3	Homo sapiens	0-4
33758937-10	2021	T3 reduced PD-1 expression in human Tregs in a concentration- and time-dependent manner in vitro.	Triiodothyronine	0-2	programmed cell death 1	Homo sapiens	11-15
33076783-10	2021	Importantly, SRC3 (-/-) tadpoles had inhibited/delayed intestinal remodeling during natural and T3-induced metamorphosis, including reduced adult intestinal stem cell proliferation and apoptosis of larval epithelial cells.	Triiodothyronine	96-98	nuclear receptor coactivator 3	Xenopus tropicalis	13-17
33221455-6	2021	Stable DIO3 knock-down (DIO3-KD) in HGSOC cells led to increased T3 bioavailability and demonstrated induced apoptosis and attenuated proliferation, migration, colony formation, oncogenic signaling, Warburg effect and tumor growth in mice.	Triiodothyronine	65-67	deiodinase, iodothyronine type III	Mus musculus	7-11
33221455-6	2021	Stable DIO3 knock-down (DIO3-KD) in HGSOC cells led to increased T3 bioavailability and demonstrated induced apoptosis and attenuated proliferation, migration, colony formation, oncogenic signaling, Warburg effect and tumor growth in mice.	Triiodothyronine	65-67	deiodinase, iodothyronine type III	Mus musculus	24-28
33758937-11	2021	High levels of circulating T3 reduced PD-1 expression in Tregs, impaired Tregs function, and disrupted T-helper cell (Th1 and Th2) balance in mice treated with T3.	Triiodothyronine	27-29	programmed cell death 1	Mus musculus	38-42
33758937-12	2021	CONCLUSIONS: Tregs dysfunction in GD patients might be due to down-regulation of PD-1 expression in Tregs induced by high levels of serum T3.	Triiodothyronine	138-140	programmed cell death 1	Homo sapiens	81-85
33754028-3	2021	Cardiomyocyte number expansion by thyroid hormone (T3) during preadolescence is suppressed by the developmental induction of an ERK1/2-specific dual specificity phosphatase 5 (DUSP5).	Triiodothyronine	51-53	mitogen-activated protein kinase 3	Mus musculus	128-134
33307956-5	2021	This allows local brain generation of sufficient T3 by the Dio2-encoded type 2 deiodinase thus preventing brain hypothyroidism.	Triiodothyronine	49-51	deiodinase, iodothyronine, type II	Mus musculus	59-63
33754028-3	2021	Cardiomyocyte number expansion by thyroid hormone (T3) during preadolescence is suppressed by the developmental induction of an ERK1/2-specific dual specificity phosphatase 5 (DUSP5).	Triiodothyronine	51-53	dual specificity phosphatase 5	Mus musculus	144-174
33754028-3	2021	Cardiomyocyte number expansion by thyroid hormone (T3) during preadolescence is suppressed by the developmental induction of an ERK1/2-specific dual specificity phosphatase 5 (DUSP5).	Triiodothyronine	51-53	dual specificity phosphatase 5	Mus musculus	176-181
33598768-3	2021	Subcutaneous neck adipose tissue from cold-acclimated or triiodothyronine (T3)-treated chickens exhibited increases in the expression of avian uncoupling protein (avUCP, an ortholog of mammalian UCP2 and UCP3) gene and some known mammalian beige adipocyte-specific markers.	Triiodothyronine	57-73	uncoupling protein 2	Homo sapiens	195-199
33598768-3	2021	Subcutaneous neck adipose tissue from cold-acclimated or triiodothyronine (T3)-treated chickens exhibited increases in the expression of avian uncoupling protein (avUCP, an ortholog of mammalian UCP2 and UCP3) gene and some known mammalian beige adipocyte-specific markers.	Triiodothyronine	57-73	uncoupling protein 3	Homo sapiens	204-208
33598768-3	2021	Subcutaneous neck adipose tissue from cold-acclimated or triiodothyronine (T3)-treated chickens exhibited increases in the expression of avian uncoupling protein (avUCP, an ortholog of mammalian UCP2 and UCP3) gene and some known mammalian beige adipocyte-specific markers.	Triiodothyronine	75-77	uncoupling protein 2	Homo sapiens	195-199
33598768-3	2021	Subcutaneous neck adipose tissue from cold-acclimated or triiodothyronine (T3)-treated chickens exhibited increases in the expression of avian uncoupling protein (avUCP, an ortholog of mammalian UCP2 and UCP3) gene and some known mammalian beige adipocyte-specific markers.	Triiodothyronine	75-77	uncoupling protein 3	Homo sapiens	204-208
33383053-9	2021	Moreover, the protein expression of IGF-1/PI3K/AKT signaling-related proteins, such as IGF-1, IGF-1R, phosphorylated PI3K (p-PI3K) and p-AKT was significantly upregulated in MI mice that received T3 pretreatment, and BMS-754807 pretreatment blocked the upregulation of the expression of these signaling-related proteins.	Triiodothyronine	196-198	insulin-like growth factor I receptor	Mus musculus	94-100
33608843-8	2021	Treatment with T3 resulted in a high and significant upregulation of the hypertrophic markers COL1A1, COL10A1 and ALPL.	Triiodothyronine	15-17	collagen type I alpha 1 chain	Homo sapiens	94-100
33608843-8	2021	Treatment with T3 resulted in a high and significant upregulation of the hypertrophic markers COL1A1, COL10A1 and ALPL.	Triiodothyronine	15-17	collagen type X alpha 1 chain	Homo sapiens	102-109
33640872-0	2021	Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium.	Triiodothyronine	50-66	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	8-12
33640872-9	2021	The present study provided original evidence that T3 enhances intrinsic activation of AMPK during myocardial ischemia-reperfusion, being this enzyme involved, at least in part, in the protective effects exerted by T3, contributing to mitochondrial structure and function preservation, post-ischemic contractile recovery and conservation cellular viability.	Triiodothyronine	50-52	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	86-90
33640872-9	2021	The present study provided original evidence that T3 enhances intrinsic activation of AMPK during myocardial ischemia-reperfusion, being this enzyme involved, at least in part, in the protective effects exerted by T3, contributing to mitochondrial structure and function preservation, post-ischemic contractile recovery and conservation cellular viability.	Triiodothyronine	214-216	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	86-90
33708176-13	2021	Addition of 10 ng/ml BDNF recovered the suppressed dendrite arborization induced by T3 deficiency on 10 DIV.	Triiodothyronine	84-86	brain derived neurotrophic factor	Mus musculus	21-25
33449688-4	2021	Here, we performed MD simulations of TRalpha and TRbeta complexed to their native ligand triiodothyronine (T3) as well as several antagonists.	Triiodothyronine	89-105	T cell receptor alpha locus	Homo sapiens	37-44
33449688-4	2021	Here, we performed MD simulations of TRalpha and TRbeta complexed to their native ligand triiodothyronine (T3) as well as several antagonists.	Triiodothyronine	89-105	T cell receptor alpha locus	Homo sapiens	49-55
33449688-4	2021	Here, we performed MD simulations of TRalpha and TRbeta complexed to their native ligand triiodothyronine (T3) as well as several antagonists.	Triiodothyronine	107-109	T cell receptor alpha locus	Homo sapiens	37-44
33449688-4	2021	Here, we performed MD simulations of TRalpha and TRbeta complexed to their native ligand triiodothyronine (T3) as well as several antagonists.	Triiodothyronine	107-109	T cell receptor alpha locus	Homo sapiens	49-55
33383053-9	2021	Moreover, the protein expression of IGF-1/PI3K/AKT signaling-related proteins, such as IGF-1, IGF-1R, phosphorylated PI3K (p-PI3K) and p-AKT was significantly upregulated in MI mice that received T3 pretreatment, and BMS-754807 pretreatment blocked the upregulation of the expression of these signaling-related proteins.	Triiodothyronine	196-198	insulin-like growth factor 1	Mus musculus	36-41
33383053-9	2021	Moreover, the protein expression of IGF-1/PI3K/AKT signaling-related proteins, such as IGF-1, IGF-1R, phosphorylated PI3K (p-PI3K) and p-AKT was significantly upregulated in MI mice that received T3 pretreatment, and BMS-754807 pretreatment blocked the upregulation of the expression of these signaling-related proteins.	Triiodothyronine	196-198	thymoma viral proto-oncogene 1	Mus musculus	47-50
33383053-10	2021	SIGNIFICANCE: T3 pretreatment can protect the heart against dysfunction post-MI, which may be mediated by the activation of the IGF-1/PI3K/AKT signaling pathway.	Triiodothyronine	14-16	insulin-like growth factor 1	Mus musculus	128-133
33383053-10	2021	SIGNIFICANCE: T3 pretreatment can protect the heart against dysfunction post-MI, which may be mediated by the activation of the IGF-1/PI3K/AKT signaling pathway.	Triiodothyronine	14-16	thymoma viral proto-oncogene 1	Mus musculus	139-142
32787533-1	2021	BACKGROUND: The type 2 deiodinase (DIO2) converts thyroxine (T4) to 3,3",5-triiodothyronine (T3), modulating intracellular T3.	Triiodothyronine	93-95	deiodinase, iodothyronine, type II	Mus musculus	35-39
32718224-7	2021	RESULTS: We report the novel identification and characterization of two missense DIO1 pathogenic variants (resulting in p.Asn94Lys and p.Met201Ile) in two unrelated families presenting with abnormal thyroid hormone metabolism with elevated serum reverse triiodothyronine (rT3) levels and rT3/T3 ratios.	Triiodothyronine	254-270	deiodinase, iodothyronine, type I	Mus musculus	81-85
33125689-0	2021	Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study.	Triiodothyronine	5-21	insulin	Homo sapiens	81-88
33125689-6	2021	The strongest noted correlations were those of insulin levels with free triiodothyronine/free thyroxine (FT3/FT4) ratio (r = 0.206, p < 0.001) and FT3 (r = 0.205, p < 0.001).	Triiodothyronine	72-88	insulin	Homo sapiens	47-54
33628237-0	2021	Suppressing Effect of Free Triiodothyronine on the Negative Association between Body Mass Index and Serum Osteocalcin Levels in Euthyroid Population.	Triiodothyronine	27-43	bone gamma-carboxyglutamate protein	Homo sapiens	106-117
33397493-11	2021	Serum concentration of free 3,5,3"-triiodothyronine (FT3) was inversely correlated with BTR, and, along with SMI and albumin, was independent predictor of BTR (SMI, beta = - 0.321, p < 0.001; FT3, beta = - 0.253, p = 0.001; logarithmic albumin, beta = 0.261, p = 0.003).	Triiodothyronine	28-51	albumin	Homo sapiens	236-243
32567086-7	2021	ATP enhanced the triiodothyronine-induced osteocalcin release, but HSP90 inhibitors suppressed the release.	Triiodothyronine	17-33	bone gamma-carboxyglutamate protein 2	Mus musculus	42-53
32584192-3	2021	The principal ligand for this receptor is L-thyroxine (T4), usually regarded only as a prohormone for 3,5,3"-triiodo-L-thyronine (T3), the hormone analogue that expresses thyroid hormone in the cell nucleus via nuclear receptors that are unrelated structurally to integrin alphavbeta3.	Triiodothyronine	102-128	integrin subunit alpha V	Homo sapiens	264-284
32584192-3	2021	The principal ligand for this receptor is L-thyroxine (T4), usually regarded only as a prohormone for 3,5,3"-triiodo-L-thyronine (T3), the hormone analogue that expresses thyroid hormone in the cell nucleus via nuclear receptors that are unrelated structurally to integrin alphavbeta3.	Triiodothyronine	130-132	integrin subunit alpha V	Homo sapiens	264-284
32787533-1	2021	BACKGROUND: The type 2 deiodinase (DIO2) converts thyroxine (T4) to 3,3",5-triiodothyronine (T3), modulating intracellular T3.	Triiodothyronine	123-125	deiodinase, iodothyronine, type II	Mus musculus	35-39
32787533-8	2021	The effects of T3-treatment on vascular endothelial growth factor (<i>Vegfa</i>) mRNA expression in C2C12 cells and mouse muscle were assessed.	Triiodothyronine	15-17	vascular endothelial growth factor A	Mus musculus	70-75
33361647-0	2021	Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort.	Triiodothyronine	9-25	potassium voltage-gated channel interacting protein 3	Homo sapiens	137-142
33318551-0	2020	DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling.	Triiodothyronine	95-97	dual specificity phosphatase 5	Mus musculus	0-5
33318551-0	2020	DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling.	Triiodothyronine	95-97	mitogen-activated protein kinase 3	Mus musculus	121-127
33318551-3	2020	We have previously shown that exogenous thyroid hormone (T3) stimulates cardiomyocyte proliferation in P2 cardiomyocytes, by activating insulin-like growth factor-1 receptor (IGF-1R)-mediated ERK1/2 signaling.	Triiodothyronine	57-59	insulin-like growth factor I receptor	Mus musculus	136-173
33318551-3	2020	We have previously shown that exogenous thyroid hormone (T3) stimulates cardiomyocyte proliferation in P2 cardiomyocytes, by activating insulin-like growth factor-1 receptor (IGF-1R)-mediated ERK1/2 signaling.	Triiodothyronine	57-59	insulin-like growth factor I receptor	Mus musculus	175-181
33318551-3	2020	We have previously shown that exogenous thyroid hormone (T3) stimulates cardiomyocyte proliferation in P2 cardiomyocytes, by activating insulin-like growth factor-1 receptor (IGF-1R)-mediated ERK1/2 signaling.	Triiodothyronine	57-59	mitogen-activated protein kinase 3	Mus musculus	192-198
33318551-8	2020	In young adult hearts, exogenous T3 increases cardiomyocyte numbers after DUSP5 depletion, which might be useful for eliciting cardiac regeneration.	Triiodothyronine	33-35	dual specificity phosphatase 5	Mus musculus	74-79
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	0-13
33306682-8	2020	In high-fat diet fed rats, a single dose of T3 significantly reduced total cholesterol levels and concurrently increased liver Dio1 and Me1 RNA expression.	Triiodothyronine	44-46	iodothyronine deiodinase 1	Rattus norvegicus	127-131
33306682-8	2020	In high-fat diet fed rats, a single dose of T3 significantly reduced total cholesterol levels and concurrently increased liver Dio1 and Me1 RNA expression.	Triiodothyronine	44-46	malic enzyme 1	Rattus norvegicus	136-139
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	15-17
33325362-9	2020	Correlation analysis showed that ICOS expression on CD4+ T cells was positively correlated with the level of free triiodothyronine (FT3) in the GD patients.	Triiodothyronine	114-130	inducible T cell costimulator	Homo sapiens	33-37
32780210-3	2020	Aim of this study is to evaluate a rat model of regional ischemia/reperfusion (I/R), the modification of cardiac main function after the administration of 6 microg/kg/day of triiodothyronine (T3), and the associated to DIO1, DIO2 and DIO3 gene expression.	Triiodothyronine	174-190	iodothyronine deiodinase 1	Rattus norvegicus	219-223
32780210-3	2020	Aim of this study is to evaluate a rat model of regional ischemia/reperfusion (I/R), the modification of cardiac main function after the administration of 6 microg/kg/day of triiodothyronine (T3), and the associated to DIO1, DIO2 and DIO3 gene expression.	Triiodothyronine	174-190	iodothyronine deiodinase 2	Rattus norvegicus	225-229
32780210-3	2020	Aim of this study is to evaluate a rat model of regional ischemia/reperfusion (I/R), the modification of cardiac main function after the administration of 6 microg/kg/day of triiodothyronine (T3), and the associated to DIO1, DIO2 and DIO3 gene expression.	Triiodothyronine	174-190	iodothyronine deiodinase 3	Rattus norvegicus	234-238
32780210-11	2020	The present study gives interesting new insights on DIO1, DIO2 and DIO3 in the ischemic heart and their role in relation to T3-mediated amelioration of cardiac function and structure.	Triiodothyronine	124-126	iodothyronine deiodinase 1	Rattus norvegicus	52-56
32780210-11	2020	The present study gives interesting new insights on DIO1, DIO2 and DIO3 in the ischemic heart and their role in relation to T3-mediated amelioration of cardiac function and structure.	Triiodothyronine	124-126	iodothyronine deiodinase 2	Rattus norvegicus	58-62
32780210-11	2020	The present study gives interesting new insights on DIO1, DIO2 and DIO3 in the ischemic heart and their role in relation to T3-mediated amelioration of cardiac function and structure.	Triiodothyronine	124-126	iodothyronine deiodinase 3	Rattus norvegicus	67-71
32827515-7	2020	Here, we report that Mtfp1gene expression peaks in the intestine during both natural and T3-induced metamorphosis when adult epithelial stem cell development and proliferation take place.	Triiodothyronine	89-91	mitochondrial fission process 1	Xenopus tropicalis	21-26
33325362-9	2020	Correlation analysis showed that ICOS expression on CD4+ T cells was positively correlated with the level of free triiodothyronine (FT3) in the GD patients.	Triiodothyronine	114-130	CD4 molecule	Homo sapiens	52-55
33176840-2	2020	RTH due to mutations of the THR-beta gene (hereafter, RTH-beta) is characterized by a decreased response of the target tissue to thyroid hormone, increased serum levels of free triiodothyronine (FT3) and/or free thyroxine (FT4), and inappropriate secretion of thyroid-stimulating hormone (TSH, normal or elevated).	Triiodothyronine	177-193	thyroid hormone receptor alpha	Homo sapiens	28-36
33201916-1	2020	Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN).	Triiodothyronine	17-19	thyrotropin releasing hormone	Rattus norvegicus	30-59
33201916-1	2020	Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN).	Triiodothyronine	17-19	thyrotropin releasing hormone	Rattus norvegicus	61-64
33212876-4	2020	For para substitution, inhibitory potencies for MAO-B were as follows: -Cl (T3) > -N(CH3)2 (T12) > -OCH3 (T9) > Br (T7) > F (T5) > -CH3 (T11) > -H (T1).	Triiodothyronine	76-79	monoamine oxidase B	Homo sapiens	48-53
33212876-5	2020	T6 and T3 efficiently inhibited MAO-A with IC50 values of 1.57 and 4.19 microM and had the highest selectivity indices (SIs) for MAO-B (120.8 and 107.4, respectively).	Triiodothyronine	7-9	monoamine oxidase A	Homo sapiens	32-37
33212876-5	2020	T6 and T3 efficiently inhibited MAO-A with IC50 values of 1.57 and 4.19 microM and had the highest selectivity indices (SIs) for MAO-B (120.8 and 107.4, respectively).	Triiodothyronine	7-9	monoamine oxidase B	Homo sapiens	129-134
33117292-6	2020	Subjects with higher level of serum free triiodothyronine (T3) and free thyroxine (T4) had higher levels of circulating TSK.	Triiodothyronine	41-57	tsukushi, small leucine rich proteoglycan	Homo sapiens	120-123
32768645-1	2020	Use of the oxadiazolone acid isostere in triiodothyronine analogs yielded potent and selective agonists for the thyroid hormone receptor beta.	Triiodothyronine	41-57	thyroid hormone receptor beta	Rattus norvegicus	112-141
32924709-6	2020	Together, we describe a novel role of T3 in modulating the innate immune response and identify the importance of PKR in regulating T3-induced immune activation.	Triiodothyronine	131-133	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	113-116
33120839-10	2020	Free triiodothyronine and free thyroxine are negatively correlated with serum CK concentration.	Triiodothyronine	5-21	cytidine/uridine monophosphate kinase 1	Homo sapiens	78-80
32969079-3	2020	Here, we show that T3-induced increase in energy expenditure requires thyroid hormone receptor alpha 1 (TRalpha1 ) in skeletal muscle, but that T3-mediated elevation in body temperature is achieved in the absence of muscle-TRalpha1 .	Triiodothyronine	19-21	detected by T cells 1	Mus musculus	104-112
33100099-0	2022	Liothyronine could block the programmed death-ligand 1 (PDL1) activity: an e-Pharmacophore modeling and virtual screening study.	Triiodothyronine	0-12	CD274 molecule	Sus scrofa	29-54
33100099-0	2022	Liothyronine could block the programmed death-ligand 1 (PDL1) activity: an e-Pharmacophore modeling and virtual screening study.	Triiodothyronine	0-12	CD274 molecule	Sus scrofa	56-60
33097005-8	2020	Similarly, among the various drought-hardening treatments, T3 improved both the enzymatic (POD, CAT, APX) and non-enzymatic (AsA) defense systems along with the elevated levels of proline and soluble sugar to mitigate the negative effects of oxidative damage and bringing osmoregulation in tobacco plants.	Triiodothyronine	59-61	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	101-104
33064779-7	2020	Unexpectedly, we found that the CLK inhibitor T3 rapidly induced apoptosis in A2780 cells and G2/M cell cycle arrest in HCT116 cells.	Triiodothyronine	46-48	CDC like kinase 1	Homo sapiens	32-35
32453466-4	2020	Primary murine osteoblasts treated with 3,3",5-triiodo-L-thyronine (T3 ) showed an enhanced differentiation potential, which was associated with activated canonical BMP/SMAD signaling reflected by SMAD1/5/8 phosphorylation.	Triiodothyronine	40-66	SMAD family member 1	Mus musculus	169-173
32453466-4	2020	Primary murine osteoblasts treated with 3,3",5-triiodo-L-thyronine (T3 ) showed an enhanced differentiation potential, which was associated with activated canonical BMP/SMAD signaling reflected by SMAD1/5/8 phosphorylation.	Triiodothyronine	40-66	SMAD family member 1	Mus musculus	197-206
32453466-4	2020	Primary murine osteoblasts treated with 3,3",5-triiodo-L-thyronine (T3 ) showed an enhanced differentiation potential, which was associated with activated canonical BMP/SMAD signaling reflected by SMAD1/5/8 phosphorylation.	Triiodothyronine	68-70	SMAD family member 1	Mus musculus	169-173
32453466-4	2020	Primary murine osteoblasts treated with 3,3",5-triiodo-L-thyronine (T3 ) showed an enhanced differentiation potential, which was associated with activated canonical BMP/SMAD signaling reflected by SMAD1/5/8 phosphorylation.	Triiodothyronine	68-70	SMAD family member 1	Mus musculus	197-206
32453466-5	2020	Blocking BMP signaling at the receptor (LDN193189) and ligand level (noggin, anti-BMP2/BMP4 neutralizing antibodies) inhibited T3 -induced osteogenic differentiation.	Triiodothyronine	127-129	noggin	Mus musculus	69-75
32453466-5	2020	Blocking BMP signaling at the receptor (LDN193189) and ligand level (noggin, anti-BMP2/BMP4 neutralizing antibodies) inhibited T3 -induced osteogenic differentiation.	Triiodothyronine	127-129	bone morphogenetic protein 2	Mus musculus	82-86
32453466-5	2020	Blocking BMP signaling at the receptor (LDN193189) and ligand level (noggin, anti-BMP2/BMP4 neutralizing antibodies) inhibited T3 -induced osteogenic differentiation.	Triiodothyronine	127-129	bone morphogenetic protein 4	Mus musculus	87-91
33117292-6	2020	Subjects with higher level of serum free triiodothyronine (T3) and free thyroxine (T4) had higher levels of circulating TSK.	Triiodothyronine	59-61	tsukushi, small leucine rich proteoglycan	Homo sapiens	120-123
33117292-8	2020	In multivariable linear regression analyses, circulating TSK concentrations were significantly associated with serum free T3, free T4, thyroid stimulating hormone, thyrotropin receptor antibody, total cholesterol, low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), and basal metabolic rate (all P < 0.01), adjusting for age, gender, smoking, and body mass index (BMI).	Triiodothyronine	122-124	tsukushi, small leucine rich proteoglycan	Homo sapiens	57-60
32623180-10	2020	T3 enhanced thrb expression in the brain, jaw cartilage and intestine, while thrb expression was suppressed in the liver.	Triiodothyronine	0-2	thyroid hormone receptor beta	Danio rerio	12-16
33252592-2	2020	The main pathogenic role of the disease is attributed to TSH receptor antibodies (TRAb), which stimulate the thyroid gland to increase production of the most active thyroid hormone- triiodothyronine (T3).	Triiodothyronine	182-198	thyroid stimulating hormone receptor	Homo sapiens	57-69
33252592-2	2020	The main pathogenic role of the disease is attributed to TSH receptor antibodies (TRAb), which stimulate the thyroid gland to increase production of the most active thyroid hormone- triiodothyronine (T3).	Triiodothyronine	200-202	thyroid stimulating hormone receptor	Homo sapiens	57-69
32987653-0	2020	T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.	Triiodothyronine	0-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	31-35
32987653-2	2020	Even though triiodothyronine (T3) has long been recognized as a critical regulator of the cardiac Myh isoform composition, its role as a modulator of the Mhrt/Brg1 axis is still unexplored.	Triiodothyronine	12-28	mutY DNA glycosylase	Rattus norvegicus	98-101
32987653-2	2020	Even though triiodothyronine (T3) has long been recognized as a critical regulator of the cardiac Myh isoform composition, its role as a modulator of the Mhrt/Brg1 axis is still unexplored.	Triiodothyronine	30-32	mutY DNA glycosylase	Rattus norvegicus	98-101
32987653-7	2020	Mechanistically, T3 activates the Mhrt promoter at two putative thyroid hormone responsive elements (TRE) located in a crucial region that is necessary for both Mhrt activation and Brg1-dependent Mhrt repression.	Triiodothyronine	17-19	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	181-185
32894141-0	2020	Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.	Triiodothyronine	14-26	T cell immunoreceptor with Ig and ITIM domains	Mus musculus	101-106
32894141-0	2020	Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.	Triiodothyronine	14-26	poliovirus receptor	Mus musculus	107-110
32894141-10	2020	Through virtual screening, binding, and blocking assay, liothyronine was discovered to bind PVR and block the interaction of TIGIT/PVR.	Triiodothyronine	56-68	poliovirus receptor	Mus musculus	92-95
32894141-10	2020	Through virtual screening, binding, and blocking assay, liothyronine was discovered to bind PVR and block the interaction of TIGIT/PVR.	Triiodothyronine	56-68	T cell immunoreceptor with Ig and ITIM domains	Mus musculus	125-130
32894141-10	2020	Through virtual screening, binding, and blocking assay, liothyronine was discovered to bind PVR and block the interaction of TIGIT/PVR.	Triiodothyronine	56-68	poliovirus receptor	Mus musculus	131-134
32894141-11	2020	Liothyronine could enhance the function of CD4+ and CD8+ T cells in PBMCs.	Triiodothyronine	0-12	CD4 antigen	Mus musculus	43-46
32894141-12	2020	Besides, in the Jurkat-hTIGIT and CHOK1-hPVR coculture assay, liothyronine could reverse the IL-2 secretion inhibition resulted by TIGIT/PVR ligation.	Triiodothyronine	62-74	interleukin 2	Mus musculus	93-97
32894141-12	2020	Besides, in the Jurkat-hTIGIT and CHOK1-hPVR coculture assay, liothyronine could reverse the IL-2 secretion inhibition resulted by TIGIT/PVR ligation.	Triiodothyronine	62-74	T cell immunoreceptor with Ig and ITIM domains	Mus musculus	24-29
32894141-12	2020	Besides, in the Jurkat-hTIGIT and CHOK1-hPVR coculture assay, liothyronine could reverse the IL-2 secretion inhibition resulted by TIGIT/PVR ligation.	Triiodothyronine	62-74	poliovirus receptor	Mus musculus	41-44
32894141-14	2020	The immune cell depletion model showed that the anti-tumor effects of liothyronine depends on CD4+ T cells, CD8+ T cells and NK cells.	Triiodothyronine	70-82	CD4 antigen	Mus musculus	94-97
32894141-15	2020	CONCLUSIONS: A small molecule liothyronine was discovered to serve as a potential candidate for cancer immunotherapy by blocking the immune checkpoint TIGIT/PVR.	Triiodothyronine	30-42	T cell immunoreceptor with Ig and ITIM domains	Mus musculus	151-156
32894141-15	2020	CONCLUSIONS: A small molecule liothyronine was discovered to serve as a potential candidate for cancer immunotherapy by blocking the immune checkpoint TIGIT/PVR.	Triiodothyronine	30-42	poliovirus receptor	Mus musculus	157-160
32389727-7	2020	Furthermore, inhibition-related theta band activity to Nogo stimuli decreased at post-immobilization blocked session (T3-blocked).	Triiodothyronine	118-120	reticulon 4	Homo sapiens	55-59
32697836-5	2020	We previously reported that thyroid hormone receptor beta1 (TRbeta1) in the adrenal gland is mainly expressed in the inner cortex and the fate of this TRbeta1-expressing cell population can be changed by thyroid hormone (T3) treatment.	Triiodothyronine	221-223	detected by T cells 1	Mus musculus	60-67
32697836-5	2020	We previously reported that thyroid hormone receptor beta1 (TRbeta1) in the adrenal gland is mainly expressed in the inner cortex and the fate of this TRbeta1-expressing cell population can be changed by thyroid hormone (T3) treatment.	Triiodothyronine	221-223	detected by T cells 1	Mus musculus	151-158
32219692-3	2020	AIM: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	268-284	serpin family A member 7	Homo sapiens	166-190
32219692-3	2020	AIM: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	268-284	serpin family A member 7	Homo sapiens	192-195
32219692-3	2020	AIM: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	286-288	serpin family A member 7	Homo sapiens	166-190
32219692-3	2020	AIM: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	286-288	serpin family A member 7	Homo sapiens	192-195
32623180-11	2020	T3 exposure suppressed the transcript levels of dio1 and dio2 in the liver, brain, gastrointestinal tract and craniofacial tissues, while dio2 signalling was also suppressed in the pituitary gland.	Triiodothyronine	0-2	iodothyronine deiodinase 1	Danio rerio	48-52
32623180-11	2020	T3 exposure suppressed the transcript levels of dio1 and dio2 in the liver, brain, gastrointestinal tract and craniofacial tissues, while dio2 signalling was also suppressed in the pituitary gland.	Triiodothyronine	0-2	iodothyronine deiodinase 2	Danio rerio	57-61
32623180-12	2020	Dio3b expression was induced by T3 exposure in the jaw cartilage, pectoral fins and brain.	Triiodothyronine	32-34	iodothyronine deiodinase 3b	Danio rerio	0-5
32688342-6	2020	Subjects with higher levels of serum free triiodothyronine (T3) and free thyroxine (T4) had higher levels of circulating Gpnmb.	Triiodothyronine	42-58	glycoprotein nmb	Homo sapiens	121-126
32688342-6	2020	Subjects with higher levels of serum free triiodothyronine (T3) and free thyroxine (T4) had higher levels of circulating Gpnmb.	Triiodothyronine	60-62	glycoprotein nmb	Homo sapiens	121-126
32522588-7	2020	MEHP-treated adipocytes exhibited brown adipocyte-like characteristics, i.e., increased mitochondrial proton leak, triiodothyronine-induced Bmp8b expression, decreased inflammation, and smaller lipid droplets.	Triiodothyronine	115-131	bone morphogenetic protein 8b	Mus musculus	140-145
32850840-0	2020	Triiodothyronine Potentiates BMP9-Induced Osteogenesis in Mesenchymal Stem Cells Through the Activation of AMPK/p38 Signaling.	Triiodothyronine	0-16	growth differentiation factor 2	Mus musculus	29-33
32952957-0	2020	Left ventricular phosphorylation patterns of Akt and ERK1/2 after triiodothyronine intracoronary perfusion in isolated hearts and short-term in vivo treatment in Wistar rats.	Triiodothyronine	66-82	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
32952957-0	2020	Left ventricular phosphorylation patterns of Akt and ERK1/2 after triiodothyronine intracoronary perfusion in isolated hearts and short-term in vivo treatment in Wistar rats.	Triiodothyronine	66-82	mitogen activated protein kinase 3	Rattus norvegicus	53-59
32952957-1	2020	Objectives: To determine the effects of triiodothyronine (T3) intracoronary perfusion in isolated hearts and short-term administration in rats on the left ventricular (LV) phosphorylation patterns of Akt and ERK1/2.	Triiodothyronine	40-56	mitogen activated protein kinase 3	Rattus norvegicus	208-214
32952957-1	2020	Objectives: To determine the effects of triiodothyronine (T3) intracoronary perfusion in isolated hearts and short-term administration in rats on the left ventricular (LV) phosphorylation patterns of Akt and ERK1/2.	Triiodothyronine	58-60	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
32952957-11	2020	Short-term T3 treatment provoked cardiac hypertrophy coincidental with increased LV function and associated with transient Akt activation and cyclic ERK1/2 inhibition; which implies activation of physiological hypertrophy signaling and deactivation of pathological hypertrophy signaling, respectively.	Triiodothyronine	11-13	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
32952957-11	2020	Short-term T3 treatment provoked cardiac hypertrophy coincidental with increased LV function and associated with transient Akt activation and cyclic ERK1/2 inhibition; which implies activation of physiological hypertrophy signaling and deactivation of pathological hypertrophy signaling, respectively.	Triiodothyronine	11-13	mitogen activated protein kinase 3	Rattus norvegicus	149-155
32867566-8	2020	Spearman"s correlation analysis showed that serum CysC levels were negatively correlated with free triiodothyronine (FT3), and positively correlated with serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb).	Triiodothyronine	99-115	cystatin C	Homo sapiens	50-54
32850840-9	2020	Co-treatment with BMP9 and T3 can promote AMPK and p38 phosphorylation, and pretreatment with the AMPK inhibitor compound C and siRNA can abolish phosphorylation of p38 and BMP9+T3-induced ALP activity.	Triiodothyronine	178-180	growth differentiation factor 2	Mus musculus	18-22
32850840-0	2020	Triiodothyronine Potentiates BMP9-Induced Osteogenesis in Mesenchymal Stem Cells Through the Activation of AMPK/p38 Signaling.	Triiodothyronine	0-16	mitogen-activated protein kinase 14	Mus musculus	112-115
32850840-8	2020	Furthermore, T3 promotes BMP9-induced bone formation by fetal limb explant cultures and ectopic MSC implantation.	Triiodothyronine	13-15	growth differentiation factor 2	Mus musculus	25-29
32850840-9	2020	Co-treatment with BMP9 and T3 can promote AMPK and p38 phosphorylation, and pretreatment with the AMPK inhibitor compound C and siRNA can abolish phosphorylation of p38 and BMP9+T3-induced ALP activity.	Triiodothyronine	27-29	mitogen-activated protein kinase 14	Mus musculus	51-54
32850840-9	2020	Co-treatment with BMP9 and T3 can promote AMPK and p38 phosphorylation, and pretreatment with the AMPK inhibitor compound C and siRNA can abolish phosphorylation of p38 and BMP9+T3-induced ALP activity.	Triiodothyronine	27-29	growth differentiation factor 2	Mus musculus	173-177
32223187-0	2020	Triiodothyronine attenuates silica-induced oxidative stress, inflammation, and apoptosis via thyroid hormone receptor alpha in differentiated THP-1 macrophages.	Triiodothyronine	0-16	thyroid hormone receptor alpha	Homo sapiens	93-123
32733267-3	2020	The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels.	Triiodothyronine	119-138	natriuretic peptide B	Rattus norvegicus	44-69
32733267-3	2020	The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels.	Triiodothyronine	119-138	natriuretic peptide B	Homo sapiens	71-74
32733267-3	2020	The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels.	Triiodothyronine	140-142	natriuretic peptide B	Rattus norvegicus	44-69
32733267-3	2020	The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels.	Triiodothyronine	140-142	natriuretic peptide B	Homo sapiens	71-74
32733267-7	2020	Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free or total T3 concentrations.	Triiodothyronine	57-59	natriuretic peptide B	Rattus norvegicus	81-84
32733267-7	2020	Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free or total T3 concentrations.	Triiodothyronine	57-59	natriuretic peptide B	Rattus norvegicus	81-84
32733267-8	2020	Myocardial BNP mRNA was increased 2.5-fold in Hypo rats and its expression was decreased to normal values by 14 days of T3 treatment.	Triiodothyronine	120-122	natriuretic peptide B	Rattus norvegicus	11-14
32733267-10	2020	Treatment with T3 decreased serum BNP while increasing total T3 indicating an inverse correlation between these two biologic factors (r 2 = 0.676, p < 0.001).	Triiodothyronine	15-17	natriuretic peptide B	Rattus norvegicus	34-37
32733267-12	2020	Conclusions: Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment.	Triiodothyronine	118-120	natriuretic peptide B	Rattus norvegicus	125-128
32733267-12	2020	Conclusions: Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment.	Triiodothyronine	118-120	natriuretic peptide B	Rattus norvegicus	163-166
32733267-12	2020	Conclusions: Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment.	Triiodothyronine	231-233	natriuretic peptide B	Rattus norvegicus	125-128
32733267-12	2020	Conclusions: Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment.	Triiodothyronine	231-233	natriuretic peptide B	Rattus norvegicus	163-166
32695299-0	2020	Triiodothyronine potentiates angiogenesis-related factor expression through PI3K/AKT signaling pathway in human osteoarthritic osteoblasts.	Triiodothyronine	0-16	AKT serine/threonine kinase 1	Homo sapiens	81-84
32695299-10	2020	The physiological concentration of T3 (10-7 M) in OA osteoblasts up-regulated the expression of VEGF, HIF-1alpha, and p-AKT after 24 hr and 48 hr culture, while a higher dose of T3 displayed the adverse effects.	Triiodothyronine	35-37	vascular endothelial growth factor A	Homo sapiens	96-100
32695299-10	2020	The physiological concentration of T3 (10-7 M) in OA osteoblasts up-regulated the expression of VEGF, HIF-1alpha, and p-AKT after 24 hr and 48 hr culture, while a higher dose of T3 displayed the adverse effects.	Triiodothyronine	35-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
32695299-10	2020	The physiological concentration of T3 (10-7 M) in OA osteoblasts up-regulated the expression of VEGF, HIF-1alpha, and p-AKT after 24 hr and 48 hr culture, while a higher dose of T3 displayed the adverse effects.	Triiodothyronine	178-180	vascular endothelial growth factor A	Homo sapiens	96-100
32453730-6	2020	H3 acetylation, HAT and HDAC ChIP-seq analyses of livers from hypo- and hyperthyroid wildtype, TR deficient and NCOR1 disrupted mice reveal three types of thyroid hormone (T3)-regulated enhancers.	Triiodothyronine	172-174	nuclear receptor co-repressor 1	Mus musculus	112-117
32453730-8	2020	In presence of T3, HDAC3-NCOR1 dissociates from these enhancers leading to histone hyperacetylation, suggesting a histone acetylation rheostat function of HDACs at poised enhancers.	Triiodothyronine	15-17	histone deacetylase 3	Mus musculus	19-24
32453730-8	2020	In presence of T3, HDAC3-NCOR1 dissociates from these enhancers leading to histone hyperacetylation, suggesting a histone acetylation rheostat function of HDACs at poised enhancers.	Triiodothyronine	15-17	nuclear receptor co-repressor 1	Mus musculus	25-30
32774144-0	2020	High T3 Induces beta-Cell Insulin Resistance via Endoplasmic Reticulum Stress.	Triiodothyronine	5-7	insulin	Homo sapiens	26-33
32774144-5	2020	The results indicated that high levels of T3 significantly inhibited insulin secretion in beta-cell line.	Triiodothyronine	42-44	insulin	Homo sapiens	69-76
32774144-8	2020	Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.	Triiodothyronine	15-17	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	61-65
32774144-8	2020	Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.	Triiodothyronine	15-17	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	67-71
32774144-8	2020	Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.	Triiodothyronine	15-17	activating transcription factor 6	Homo sapiens	73-77
32774144-8	2020	Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.	Triiodothyronine	15-17	heat shock protein family A (Hsp70) member 5	Homo sapiens	83-88
32774144-8	2020	Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12.	Triiodothyronine	15-17	DNA damage inducible transcript 3	Homo sapiens	123-127
32774144-10	2020	These results suggest that high T3 levels can induce insulin resistance in beta-cell line by activating ERS and the apoptotic pathway.	Triiodothyronine	32-34	insulin	Homo sapiens	53-60
32687511-1	2020	Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3"-triiodothyronine (T3) and low thyroxine (T4) levels.	Triiodothyronine	245-268	solute carrier family 16 member 2	Homo sapiens	111-115
32687511-1	2020	Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3"-triiodothyronine (T3) and low thyroxine (T4) levels.	Triiodothyronine	270-272	solute carrier family 16 member 2	Homo sapiens	111-115
32671080-7	2020	However, higher levels of triiodothyronine (T3) were associated with better verbal memory performance (immediate and delayed recall tasks) in APOE epsilon4 carriers, whereas a negative association was found in APOE epsilon4 non-carriers.	Triiodothyronine	26-42	apolipoprotein E	Homo sapiens	142-146
32671080-7	2020	However, higher levels of triiodothyronine (T3) were associated with better verbal memory performance (immediate and delayed recall tasks) in APOE epsilon4 carriers, whereas a negative association was found in APOE epsilon4 non-carriers.	Triiodothyronine	44-46	apolipoprotein E	Homo sapiens	142-146
32671080-9	2020	Conclusions: These findings suggest that in patients with SCD, T3 might have a protective effect on memory in those who are APOE epsilon4 carriers.	Triiodothyronine	63-65	apolipoprotein E	Homo sapiens	124-128
32229369-3	2020	In addition, growth hormone can enhance the metabolism of thyroxine to triiodothyronine, uncovering borderline TSH deficiency.	Triiodothyronine	71-87	growth hormone 1	Homo sapiens	13-27
32223187-0	2020	Triiodothyronine attenuates silica-induced oxidative stress, inflammation, and apoptosis via thyroid hormone receptor alpha in differentiated THP-1 macrophages.	Triiodothyronine	0-16	GLI family zinc finger 2	Homo sapiens	142-147
32126395-4	2020	T3 (100 nM) treatment induced up-regulated expression of WT1 over time (p < 0.05), while the expression of polarity proteins (Par3, Par6b, and E-cadherin) and Wnt4 were affected to varying degrees (p < 0.05).	Triiodothyronine	0-2	WT1	Bos taurus	57-60
32391142-7	2020	We observed that Mettl1 was activated by T3 in the intestine during both natural and T3-induced metamorphosis and that its mRNA level peaks at the climax of intestinal remodeling.	Triiodothyronine	41-43	methyltransferase 1, tRNA methylguanosine	Xenopus tropicalis	17-23
32205094-2	2020	Thyroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as GC-1, are known to impact lipid and bile acid (BA) metabolism and induce hepatocyte proliferation downstream of Wnt/beta-catenin signaling after surgical resection; however, these drugs have yet to be studied as potential therapeutics for cholestatic liver disease.	Triiodothyronine	16-32	guanylate cyclase 2e	Mus musculus	90-94
32205094-2	2020	Thyroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as GC-1, are known to impact lipid and bile acid (BA) metabolism and induce hepatocyte proliferation downstream of Wnt/beta-catenin signaling after surgical resection; however, these drugs have yet to be studied as potential therapeutics for cholestatic liver disease.	Triiodothyronine	16-32	catenin (cadherin associated protein), beta 1	Mus musculus	206-218
31901531-0	2020	Rno-miR-224-5p contributes to 2,2",4,4"-tetrabromodiphenyl ether-induced low triiodothyronine in rats by targeting deiodinases.	Triiodothyronine	77-93	microRNA 224	Rattus norvegicus	0-11
32007562-15	2020	PTH in T3 was lower in cases (1.6 (1.6-2.8) vs 2.3 (2.1-2.8) pmol/L) but 1,25(OH)2D concentrations were similar.	Triiodothyronine	7-9	parathyroid hormone	Homo sapiens	0-3
32496146-4	2020	Thyroxine-binding globulin (TBG) is the major carrier protein for thyroxine (T4) and triiodothyronine (T3) in blood.	Triiodothyronine	85-101	serpin family A member 7	Homo sapiens	0-26
32126395-4	2020	T3 (100 nM) treatment induced up-regulated expression of WT1 over time (p < 0.05), while the expression of polarity proteins (Par3, Par6b, and E-cadherin) and Wnt4 were affected to varying degrees (p < 0.05).	Triiodothyronine	0-2	par-3 family cell polarity regulator	Bos taurus	126-130
32496146-4	2020	Thyroxine-binding globulin (TBG) is the major carrier protein for thyroxine (T4) and triiodothyronine (T3) in blood.	Triiodothyronine	85-101	serpin family A member 7	Homo sapiens	28-31
32496146-4	2020	Thyroxine-binding globulin (TBG) is the major carrier protein for thyroxine (T4) and triiodothyronine (T3) in blood.	Triiodothyronine	103-105	serpin family A member 7	Homo sapiens	0-26
32496146-4	2020	Thyroxine-binding globulin (TBG) is the major carrier protein for thyroxine (T4) and triiodothyronine (T3) in blood.	Triiodothyronine	103-105	serpin family A member 7	Homo sapiens	28-31
32126395-4	2020	T3 (100 nM) treatment induced up-regulated expression of WT1 over time (p < 0.05), while the expression of polarity proteins (Par3, Par6b, and E-cadherin) and Wnt4 were affected to varying degrees (p < 0.05).	Triiodothyronine	0-2	par-6 family cell polarity regulator beta	Bos taurus	132-137
32126395-4	2020	T3 (100 nM) treatment induced up-regulated expression of WT1 over time (p < 0.05), while the expression of polarity proteins (Par3, Par6b, and E-cadherin) and Wnt4 were affected to varying degrees (p < 0.05).	Triiodothyronine	0-2	cadherin 1	Bos taurus	143-153
32126395-4	2020	T3 (100 nM) treatment induced up-regulated expression of WT1 over time (p < 0.05), while the expression of polarity proteins (Par3, Par6b, and E-cadherin) and Wnt4 were affected to varying degrees (p < 0.05).	Triiodothyronine	0-2	Wnt family member 4	Bos taurus	159-163
31809938-4	2020	Herein, we show that exposure of adult female mice to PFBS (200 mg/kg/day) (PFBS-mice) caused a decrease in the levels of serum total triiodothyronine and thyroxine, which depended on the activation of peroxisome proliferator-activated receptor alpha (PPARalpha).	Triiodothyronine	134-150	peroxisome proliferator activated receptor alpha	Mus musculus	202-250
32577285-5	2020	Previous research demonstrated that triiodothyronine (T3) can be measured successfully in faecal matter of African elephants, Loxodonta africana.	Triiodothyronine	36-52	metallothionein 3	Mus musculus	54-56
33029227-0	2020	TRIIODOTHYRONINE ACTIVATES GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3 VIA AGGTCA-LIKE-DIRECT-REPEAT-4 TYPE THYROID HORMONE RESPONSE ELEMENT.	Triiodothyronine	0-16	glycerol-3-phosphate acyltransferase 3	Homo sapiens	27-65
33029227-10	2020	Conclusion: Triiodothyronine could activate the GPAT3 through DR4-TRE-like sequence binding to participate in lipogenic regulation.	Triiodothyronine	12-28	glycerol-3-phosphate acyltransferase 3	Homo sapiens	48-53
33029227-10	2020	Conclusion: Triiodothyronine could activate the GPAT3 through DR4-TRE-like sequence binding to participate in lipogenic regulation.	Triiodothyronine	12-28	major histocompatibility complex, class II, DR beta 4	Homo sapiens	62-65
31874199-0	2020	Triiodothyronine activated extranuclear pathways upregulate adiponectin and leptin in murine adipocytes.	Triiodothyronine	0-16	adiponectin, C1Q and collagen domain containing	Mus musculus	60-71
32014425-9	2020	Interestingly, T3 administration reversed the observed acinar cell alterations and restored pancreatic enzyme content, by augmenting amylase and lipase and attenuating trypsin levels, but failed to change collagen content.	Triiodothyronine	15-17	lipase G, endothelial type	Rattus norvegicus	145-151
32014425-10	2020	Increased levels of lipase and decreased trypsin were also observed in T3-treated SO rats.	Triiodothyronine	71-73	lipase G, endothelial type	Rattus norvegicus	20-26
31743080-4	2020	Thus, the present study investigates the in vitro effects of T3s on LOX expression in human osteoblastic MG-63 cells.	Triiodothyronine	61-64	lysyl oxidase	Homo sapiens	68-71
31874199-0	2020	Triiodothyronine activated extranuclear pathways upregulate adiponectin and leptin in murine adipocytes.	Triiodothyronine	0-16	leptin	Mus musculus	76-82
31874199-1	2020	Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin alphaVbeta3 pathways, modulating gene expression.	Triiodothyronine	129-145	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
31874199-1	2020	Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin alphaVbeta3 pathways, modulating gene expression.	Triiodothyronine	129-145	leptin	Mus musculus	16-22
31874199-1	2020	Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin alphaVbeta3 pathways, modulating gene expression.	Triiodothyronine	129-145	mitogen-activated protein kinase 1	Mus musculus	170-174
31874199-1	2020	Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin alphaVbeta3 pathways, modulating gene expression.	Triiodothyronine	129-145	mitogen-activated protein kinase 1	Mus musculus	175-178
33122872-5	2020	In specific, replicated were critical roles of the conversion of thyroid prohormone by 2 iodothyronine deiodinase (Dio2) into triiodothyronine (T3) in the regulation of the timing of imprinting learning.	Triiodothyronine	126-142	iodothyronine deiodinase 2	Homo sapiens	115-119
31617239-8	2020	Positive correlation was found between the reactivity to MDA-modified CAT and the triiodothyronine level (P &lt; .001, r = .6).	Triiodothyronine	82-98	catalase	Homo sapiens	70-73
31963885-3	2020	Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones.	Triiodothyronine	20-22	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	66-113
31963885-3	2020	Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones.	Triiodothyronine	20-22	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	115-120
33122872-5	2020	In specific, replicated were critical roles of the conversion of thyroid prohormone by 2 iodothyronine deiodinase (Dio2) into triiodothyronine (T3) in the regulation of the timing of imprinting learning.	Triiodothyronine	144-146	iodothyronine deiodinase 2	Homo sapiens	115-119