PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18499206-3	2008	Here, we assessed the anti-proliferative and anti-invasive effects of delphinidin on HGF-mediated responses in the immortalized MCF-10A breast cell line.	delphinidin	70-81	hepatocyte growth factor	Homo sapiens	85-88
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	hepatocyte growth factor	Homo sapiens	67-70
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	hepatocyte growth factor	Homo sapiens	101-104
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	protein tyrosine kinase 2	Homo sapiens	238-241
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	246-249
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	GRB2 associated binding protein 1	Homo sapiens	310-315
18499206-4	2008	Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2.	delphinidin	24-35	growth factor receptor bound protein 2	Homo sapiens	320-325
18499206-5	2008	In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways.	delphinidin	13-24	hepatocyte growth factor	Homo sapiens	73-76
18499206-5	2008	In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways.	delphinidin	13-24	AKT serine/threonine kinase 1	Homo sapiens	119-122
18499206-5	2008	In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways.	delphinidin	13-24	mechanistic target of rapamycin kinase	Homo sapiens	123-127
18618485-3	2008	In addition, delphinidin, quercetin and (-)-epigallocatechin-3-gallate (EGCG) were found to suppress the phosphorylation of the ErbB2 receptor, with delphinidin exhibiting the strongest inhibitory properties.	delphinidin	149-160	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-133
18499206-5	2008	In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways.	delphinidin	13-24	ribosomal protein S6 kinase B1	Homo sapiens	128-134
18499206-6	2008	Delphinidin was found to repress HGF-activated NFkappaB transcription with a decrease in (i) phosphorylation of IKKalpha/beta and IkappaBalpha, and (ii) activation and nuclear translocation of NFkappaB/p65.	delphinidin	0-11	hepatocyte growth factor	Homo sapiens	33-36
18499206-6	2008	Delphinidin was found to repress HGF-activated NFkappaB transcription with a decrease in (i) phosphorylation of IKKalpha/beta and IkappaBalpha, and (ii) activation and nuclear translocation of NFkappaB/p65.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	47-55
18499206-6	2008	Delphinidin was found to repress HGF-activated NFkappaB transcription with a decrease in (i) phosphorylation of IKKalpha/beta and IkappaBalpha, and (ii) activation and nuclear translocation of NFkappaB/p65.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	193-201
18499206-6	2008	Delphinidin was found to repress HGF-activated NFkappaB transcription with a decrease in (i) phosphorylation of IKKalpha/beta and IkappaBalpha, and (ii) activation and nuclear translocation of NFkappaB/p65.	delphinidin	0-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	202-205
18499206-7	2008	Inhibition of HGF-mediated membrane translocation of PKCalpha as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells.	delphinidin	132-143	hepatocyte growth factor	Homo sapiens	14-17
18499206-7	2008	Inhibition of HGF-mediated membrane translocation of PKCalpha as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells.	delphinidin	132-143	protein kinase C alpha	Homo sapiens	53-61
18499206-7	2008	Inhibition of HGF-mediated membrane translocation of PKCalpha as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells.	delphinidin	132-143	signal transducer and activator of transcription 3	Homo sapiens	102-107
18499206-8	2008	Finally, decreased cell viability of Met receptor expressing breast cancer cells treated with delphinidin argues for a potential role of the agent in the prevention of HGF-mediated activation of various signaling pathways implicated in breast cancer.	delphinidin	94-105	hepatocyte growth factor	Homo sapiens	168-171
18603805-3	2008	A proteomic analysis followed by western blotting showed that phosphoglycerate kinase 1 (PGK1) was induced by hydrogen peroxide in a dose-dependent manner, while its expression was suppressed by a co-treatment with delphinidin, a known antioxidant.	delphinidin	215-226	phosphoglycerate kinase 1	Homo sapiens	62-87
18603805-3	2008	A proteomic analysis followed by western blotting showed that phosphoglycerate kinase 1 (PGK1) was induced by hydrogen peroxide in a dose-dependent manner, while its expression was suppressed by a co-treatment with delphinidin, a known antioxidant.	delphinidin	215-226	phosphoglycerate kinase 1	Homo sapiens	89-93
18618485-0	2008	Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.	delphinidin	14-25	epidermal growth factor receptor	Homo sapiens	93-97
18618485-0	2008	Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.	delphinidin	14-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-111
18618485-1	2008	In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin.	delphinidin	22-33	epidermal growth factor receptor	Homo sapiens	83-115
18618485-4	2008	Their potency to suppress the ErbB2 receptor phosphorylation can be summarised as delphinidin > EGCG > quercetin.	delphinidin	82-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-35
18618485-1	2008	In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin.	delphinidin	22-33	epidermal growth factor receptor	Homo sapiens	117-121
18618485-3	2008	In addition, delphinidin, quercetin and (-)-epigallocatechin-3-gallate (EGCG) were found to suppress the phosphorylation of the ErbB2 receptor, with delphinidin exhibiting the strongest inhibitory properties.	delphinidin	13-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-133
18618485-5	2008	The effectiveness of delphinidin against the EGFR and the ErbB2 receptor was comparable, indicating a broader spectrum of activity against receptor tyrosine kinases.	delphinidin	21-32	epidermal growth factor receptor	Homo sapiens	45-49
18618485-6	2008	At low micromolar concentrations delphinidin showed some preference towards the ErbB2 receptor.	delphinidin	33-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	80-85
18618485-8	2008	Whereas quercetin was most effective against the EGFR, delphinidin exhibited some preference towards the ErbB2 receptor.	delphinidin	55-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-110
18339683-0	2008	Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling.	delphinidin	0-11	platelet derived growth factor receptor, beta polypeptide	Mus musculus	100-105
18339683-4	2008	In the present study, we show that delphinidin also inhibits activation of the platelet-derived growth factor (PDGF)-BB receptor-beta [platelet-derived growth factor receptor-beta (PDGFR-beta)] in SMC and that this inhibition may contribute to its antitumor effect.	delphinidin	35-46	platelet derived growth factor receptor, beta polypeptide	Mus musculus	181-191
18339683-5	2008	The inhibitory effect of delphinidin on PDGFR-beta was very rapid and led to the inhibition of PDGF-BB-induced activation of extracellular signal-regulated kinase (ERK)-1/2 signaling and of the chemotactic motility of SMC, as well as the differentiation and stabilization of EC and SMC into capillary-like tubular structures in a three-dimensional coculture system.	delphinidin	25-36	platelet derived growth factor receptor, beta polypeptide	Mus musculus	40-50
18339683-5	2008	The inhibitory effect of delphinidin on PDGFR-beta was very rapid and led to the inhibition of PDGF-BB-induced activation of extracellular signal-regulated kinase (ERK)-1/2 signaling and of the chemotactic motility of SMC, as well as the differentiation and stabilization of EC and SMC into capillary-like tubular structures in a three-dimensional coculture system.	delphinidin	25-36	mitogen-activated protein kinase 3	Mus musculus	125-172
16288501-5	2006	CY and DP both increased the protein level of eNOS, but DP showed the major effect raising eNOS protein in a dose-dependent manner.	delphinidin	7-9	nitric oxide synthase 3	Homo sapiens	46-50
16921400-0	2006	Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	50-54
16921400-0	2006	Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	123-126
16921400-0	2006	Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	127-131
16921400-0	2006	Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	136-139
16921400-5	2006	KEY RESULTS: The inhibitory effect of RWPs on PDGF(AB)-induced release of VEGF was mimicked by delphinidin but not by quercetin, catechins, resveratrol, gallic acid or caffeic acid.	delphinidin	95-106	vascular endothelial growth factor A	Homo sapiens	74-78
16921400-6	2006	In the anthocyanin class, not only delphinidin but also cyanidin prevented VEGF release whereas malvidin and peonidin were without effect.	delphinidin	35-46	vascular endothelial growth factor A	Homo sapiens	75-79
16921400-9	2006	Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB)-induced expression of VEGF, in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin.	delphinidin	194-205	vascular endothelial growth factor A	Homo sapiens	104-108
16921400-9	2006	Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB)-induced expression of VEGF, in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin.	delphinidin	194-205	mitogen-activated protein kinase 8	Homo sapiens	167-170
16823770-5	2007	Dp decreases the expression of both urokinase-type plasminogen activator receptor (uPAR) and the low-density lipoprotein receptor-related protein (LRP), acting at the transcriptional levels.	delphinidin	0-2	plasminogen activator, urokinase receptor	Homo sapiens	36-81
16823770-5	2007	Dp decreases the expression of both urokinase-type plasminogen activator receptor (uPAR) and the low-density lipoprotein receptor-related protein (LRP), acting at the transcriptional levels.	delphinidin	0-2	plasminogen activator, urokinase receptor	Homo sapiens	83-87
16823770-5	2007	Dp decreases the expression of both urokinase-type plasminogen activator receptor (uPAR) and the low-density lipoprotein receptor-related protein (LRP), acting at the transcriptional levels.	delphinidin	0-2	LDL receptor related protein 1	Homo sapiens	147-150
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	plasminogen activator, urokinase	Homo sapiens	28-64
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	plasminogen activator, urokinase	Homo sapiens	66-69
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	serpin family E member 1	Homo sapiens	93-126
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	serpin family E member 1	Homo sapiens	128-133
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	plasminogen activator, urokinase	Homo sapiens	191-194
16823770-6	2007	In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity.	delphinidin	13-15	plasminogen activator, urokinase	Homo sapiens	191-194
16308314-0	2006	Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation.	delphinidin	0-11	kinase insert domain receptor	Homo sapiens	47-92
16308314-4	2006	In vitro, low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2.	delphinidin	32-43	vascular endothelial growth factor A	Homo sapiens	54-88
16308314-4	2006	In vitro, low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2.	delphinidin	32-43	vascular endothelial growth factor A	Homo sapiens	90-94
16308314-4	2006	In vitro, low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2.	delphinidin	32-43	kinase insert domain receptor	Homo sapiens	132-145
16308314-4	2006	In vitro, low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2.	delphinidin	32-43	kinase insert domain receptor	Homo sapiens	147-152
16308314-4	2006	In vitro, low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2.	delphinidin	32-43	kinase insert domain receptor	Homo sapiens	220-227
16308314-5	2006	Inhibition of VEGFR-2 by delphinidin inhibited the VEGF-induced activation of ERK-1/2 signaling and the chemotactic motility of human EC as well as their differentiation into capillary-like tubular structures in Matrigel and within fibrin gels.	delphinidin	25-36	kinase insert domain receptor	Homo sapiens	14-21
16308314-5	2006	Inhibition of VEGFR-2 by delphinidin inhibited the VEGF-induced activation of ERK-1/2 signaling and the chemotactic motility of human EC as well as their differentiation into capillary-like tubular structures in Matrigel and within fibrin gels.	delphinidin	25-36	vascular endothelial growth factor A	Homo sapiens	14-18
16308314-5	2006	Inhibition of VEGFR-2 by delphinidin inhibited the VEGF-induced activation of ERK-1/2 signaling and the chemotactic motility of human EC as well as their differentiation into capillary-like tubular structures in Matrigel and within fibrin gels.	delphinidin	25-36	mitogen-activated protein kinase 3	Homo sapiens	78-85
16308314-7	2006	The identification of delphinidin as a naturally occurring inhibitor of VEGF receptors suggests that this molecule possesses important antiangiogenic properties that may be helpful for the prevention and treatment of cancer.	delphinidin	22-33	vascular endothelial growth factor A	Homo sapiens	72-76
16288501-5	2006	CY and DP both increased the protein level of eNOS, but DP showed the major effect raising eNOS protein in a dose-dependent manner.	delphinidin	56-58	nitric oxide synthase 3	Homo sapiens	46-50
16288501-5	2006	CY and DP both increased the protein level of eNOS, but DP showed the major effect raising eNOS protein in a dose-dependent manner.	delphinidin	56-58	nitric oxide synthase 3	Homo sapiens	91-95
15963474-2	2005	Of five anthocyanidins, delphinidin and cyanidin inhibited LPS-induced COX-2 expression, but pelargonidin, peonidin and malvidin did not.	delphinidin	24-35	prostaglandin-endoperoxide synthase 2	Mus musculus	71-76
15963474-6	2005	Moreover, delphinidin suppressed the activations of mitogen-activated protein kinase (MAPK) including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	delphinidin	10-21	mitogen-activated protein kinase 1	Mus musculus	133-170
15963474-6	2005	Moreover, delphinidin suppressed the activations of mitogen-activated protein kinase (MAPK) including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	delphinidin	10-21	mitogen-activated protein kinase 1	Mus musculus	172-175
15963474-4	2005	Delphinidin, the most potent inhibitor, caused a dose-dependent inhibition of COX-2 expression at both mRNA and protein levels.	delphinidin	0-11	prostaglandin-endoperoxide synthase 2	Mus musculus	78-83
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	prostaglandin-endoperoxide synthase 2	Mus musculus	120-125
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	mitogen-activated protein kinase 1	Mus musculus	138-142
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	82-95
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	jun proto-oncogene	Mus musculus	229-248
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	jun proto-oncogene	Mus musculus	250-254
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	122-125
15963474-8	2005	Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta.	delphinidin	97-108	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	260-270
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	130-173
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	jun proto-oncogene	Mus musculus	197-202
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	cAMP responsive element binding protein 1	Mus musculus	212-231
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	cAMP responsive element binding protein 1	Mus musculus	233-237
15963474-6	2005	Moreover, delphinidin suppressed the activations of mitogen-activated protein kinase (MAPK) including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	delphinidin	10-21	mitogen-activated protein kinase 1	Mus musculus	86-90
15963474-6	2005	Moreover, delphinidin suppressed the activations of mitogen-activated protein kinase (MAPK) including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	delphinidin	10-21	mitogen-activated protein kinase 8	Mus musculus	102-125
15963474-6	2005	Moreover, delphinidin suppressed the activations of mitogen-activated protein kinase (MAPK) including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	delphinidin	10-21	mitogen-activated protein kinase 8	Mus musculus	127-130
15740068-4	2005	According to the appearance of the caspase-3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) in time-dependent studies, delphinidin induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase-3 activity.	delphinidin	157-168	caspase 3	Homo sapiens	35-44
15740068-4	2005	According to the appearance of the caspase-3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) in time-dependent studies, delphinidin induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase-3 activity.	delphinidin	157-168	poly(ADP-ribose) polymerase 1	Homo sapiens	94-122
15740068-4	2005	According to the appearance of the caspase-3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) in time-dependent studies, delphinidin induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase-3 activity.	delphinidin	157-168	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
15740068-4	2005	According to the appearance of the caspase-3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) in time-dependent studies, delphinidin induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase-3 activity.	delphinidin	157-168	caspase 3	Homo sapiens	282-291
15740068-5	2005	RT-PCR and Western blot data revealed that delphinidin stimulated an increase in the c-Jun and JNK phosphorylation expression at mRNA and protein levels, respectively.	delphinidin	43-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-90
15740068-5	2005	RT-PCR and Western blot data revealed that delphinidin stimulated an increase in the c-Jun and JNK phosphorylation expression at mRNA and protein levels, respectively.	delphinidin	43-54	mitogen-activated protein kinase 8	Homo sapiens	95-98
15740068-6	2005	Moreover, delphinidin-induced apoptotic cell death was accompanied by up-regulation of Bax and down-regulation of Bcl-2 protein.	delphinidin	10-21	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
15740068-6	2005	Moreover, delphinidin-induced apoptotic cell death was accompanied by up-regulation of Bax and down-regulation of Bcl-2 protein.	delphinidin	10-21	BCL2 apoptosis regulator	Homo sapiens	114-119
15740068-8	2005	Our experiments provide evidence that delphinidin is an effective apoptosis inducer in HepG(2) cells through regulation of Bcl-2 family moleculars and activation of c-Jun N-terminal kinase cascade.	delphinidin	38-49	BCL2 apoptosis regulator	Homo sapiens	123-128
15740068-8	2005	Our experiments provide evidence that delphinidin is an effective apoptosis inducer in HepG(2) cells through regulation of Bcl-2 family moleculars and activation of c-Jun N-terminal kinase cascade.	delphinidin	38-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
12888907-5	2003	The efficacious induction of apoptosis was observed at 100 micro M for 6 h. Concomitant with the apoptosis, delphinidin stimulates JNK pathway activation including JNK phosphorylation and c-jun gene expression, and activates caspase-3.	delphinidin	108-119	mitogen-activated protein kinase 8	Homo sapiens	131-134
15497183-1	2004	The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR).	delphinidin	74-85	epidermal growth factor receptor	Homo sapiens	128-160
15497183-1	2004	The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR).	delphinidin	74-85	epidermal growth factor receptor	Homo sapiens	162-166
15497183-1	2004	The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR).	delphinidin	74-77	epidermal growth factor receptor	Homo sapiens	128-160
15497183-1	2004	The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), represent potent inhibitors of the epidermal growth factor receptor (EGFR).	delphinidin	74-77	epidermal growth factor receptor	Homo sapiens	162-166
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	85-130
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	132-135
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	168-191
14514663-5	2004	Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	193-196
12888907-6	2003	Antioxidants including N-acetyl-L-cysteine (NAC) and catalase effectively block delphinidin-induced JNK phosphorylation, caspase-3 activation, and DNA fragmentation.	delphinidin	80-91	X-linked Kx blood group	Homo sapiens	44-47
12888907-6	2003	Antioxidants including N-acetyl-L-cysteine (NAC) and catalase effectively block delphinidin-induced JNK phosphorylation, caspase-3 activation, and DNA fragmentation.	delphinidin	80-91	mitogen-activated protein kinase 8	Homo sapiens	100-103
12888907-6	2003	Antioxidants including N-acetyl-L-cysteine (NAC) and catalase effectively block delphinidin-induced JNK phosphorylation, caspase-3 activation, and DNA fragmentation.	delphinidin	80-91	caspase 3	Homo sapiens	121-130
12888907-5	2003	The efficacious induction of apoptosis was observed at 100 micro M for 6 h. Concomitant with the apoptosis, delphinidin stimulates JNK pathway activation including JNK phosphorylation and c-jun gene expression, and activates caspase-3.	delphinidin	108-119	mitogen-activated protein kinase 8	Homo sapiens	164-167
12888907-5	2003	The efficacious induction of apoptosis was observed at 100 micro M for 6 h. Concomitant with the apoptosis, delphinidin stimulates JNK pathway activation including JNK phosphorylation and c-jun gene expression, and activates caspase-3.	delphinidin	108-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-193
12888907-5	2003	The efficacious induction of apoptosis was observed at 100 micro M for 6 h. Concomitant with the apoptosis, delphinidin stimulates JNK pathway activation including JNK phosphorylation and c-jun gene expression, and activates caspase-3.	delphinidin	108-119	caspase 3	Homo sapiens	225-234
12909331-0	2003	Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis.	delphinidin	68-79	proliferating cell nuclear antigen	Homo sapiens	15-21
12909331-4	2003	METHODS AND RESULTS: Vascular endothelial growth factor-stimulated human umbilical endothelial cell migration and proliferation are potently inhibited by delphinidin.	delphinidin	154-165	vascular endothelial growth factor A	Homo sapiens	21-55
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	vascular endothelial growth factor A	Homo sapiens	58-92
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	cyclin dependent kinase inhibitor 1B	Homo sapiens	127-170
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	vascular endothelial growth factor A	Homo sapiens	179-213
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	cyclin D1	Homo sapiens	234-243
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	cyclin A2	Homo sapiens	248-256
12566096-0	2003	Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2.	delphinidin	0-11	mitogen-activated protein kinase 3	Bos taurus	113-121
12871827-5	2003	Based on flow cytometry, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling analysis and detection of mitochondrial cytochrome c release, we show that delphinidin (10(-2) g l(-1)) alone had no effect either on necrosis or on apoptosis, but it significantly reduced apoptosis elicited by actinomycin D (1 micro g ml(-1), 24 h) and 7beta-hydroxycholesterol (10 micro g ml(-1), 18 h).	delphinidin	170-181	LOC104968582	Bos taurus	135-147
12566096-4	2003	This antiproliferative effect of delphinidin, is triggered by ERK-1/-2 activation, independent of nitric oxide pathway and is correlated with suppression of cell progression by blocking the cell cycle in G(0)/G(1) phase.	delphinidin	33-44	mitogen-activated protein kinase 3	Bos taurus	62-70
11262056-0	2001	The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor.	delphinidin	32-43	epidermal growth factor receptor	Homo sapiens	73-105
12188603-3	2002	Comparison of the intensities among the 3-glucosides with five different aglycons and the 3-glycosides with three different sugar moieties at C-3 showed that their strongest intensities were given by the delphinidin aglycon and 3-rutinosyl moiety, respectively.	delphinidin	204-215	complement C3	Homo sapiens	142-145
11906973-9	2002	The RWPC-induced increase in [Ca(2+)](i) was decreased by exposure to ryanodine (30 microM), whereas Provinols and delphinidin-induced increases in [Ca(2+)](i) were decreased by bradykinin (0.1 microM) and thapsigargin (1 microM) pre-treatment.	delphinidin	115-126	kininogen 1	Bos taurus	178-188
11262056-8	2001	We found that cy and del inhibited the activation of the GAL4-Elk-1 fusion protein in the concentration range where growth inhibition was observed.	delphinidin	21-24	galectin 4	Homo sapiens	57-61
11262056-8	2001	We found that cy and del inhibited the activation of the GAL4-Elk-1 fusion protein in the concentration range where growth inhibition was observed.	delphinidin	21-24	ETS transcription factor ELK1	Homo sapiens	62-67
34875956-8	2021	Additionally, In Vitro experiments, MCF-7 and BT-474 cell proliferation was inhibited in a dose-dependent manner by delphinidin and the expressions of EGFR, TOP2A and PTGS were reduced.	delphinidin	116-127	DNA topoisomerase II alpha	Homo sapiens	157-162
9581517-5	1998	Delphinidin slightly inhibited the activity of MMPs, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.	delphinidin	0-11	matrix metallopeptidase 2	Homo sapiens	47-51
7779146-1	1995	The purpose of the present study was to investigate the effects of the flavonoid delphinidin chloride (CAS 528-53-0, IdB 1056) on diabetic microangiopathy.	delphinidin	81-101	BCAR1 scaffold protein, Cas family member	Homo sapiens	103-106
34875956-8	2021	Additionally, In Vitro experiments, MCF-7 and BT-474 cell proliferation was inhibited in a dose-dependent manner by delphinidin and the expressions of EGFR, TOP2A and PTGS were reduced.	delphinidin	116-127	epidermal growth factor receptor	Homo sapiens	151-155
32155282-0	2021	The dietary anthocyanin delphinidin prevents bone resorption by inhibiting Rankl-induced differentiation of osteoclasts in a medaka (Oryzias latipes) model of osteoporosis.	delphinidin	24-35	tumor necrosis factor ligand superfamily member 11	Oryzias latipes	75-80
34200816-6	2021	We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively.	delphinidin	180-191	insulin	Homo sapiens	102-109
33955636-0	2021	Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells.	delphinidin	0-11	signal transducer and activator of transcription 3	Homo sapiens	26-31
33955636-3	2021	In our study we analyzed delphinidin modulate STAT-3 and MAPKinase signaling thereby inhbits cell proliferation and promote apoptosis.	delphinidin	25-36	signal transducer and activator of transcription 3	Homo sapiens	46-52
33955636-6	2021	In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro-apoptotic Bax, Caspase- 3,8 & 9, cytochrome C, and inhibition of anti-apoptotic protein expression.	delphinidin	32-43	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187
33955636-6	2021	In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro-apoptotic Bax, Caspase- 3,8 & 9, cytochrome C, and inhibition of anti-apoptotic protein expression.	delphinidin	32-43	caspase 3	Homo sapiens	189-205
33955636-6	2021	In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro-apoptotic Bax, Caspase- 3,8 & 9, cytochrome C, and inhibition of anti-apoptotic protein expression.	delphinidin	32-43	cytochrome c, somatic	Homo sapiens	207-219
33955636-7	2021	Studies on STAT-3 and MAPKinase signaling showed delphinidin inhibited the phosphorylation of these transcription factors" activity.	delphinidin	49-60	signal transducer and activator of transcription 3	Homo sapiens	11-17
33955636-8	2021	Inhibition of STAT-3, p38, and ERK1/2 phosphorylation and modulation pro-apoptotic protein expression might be responsible for the anticancer activity of delphinidin in colon cancer cells.	delphinidin	154-165	signal transducer and activator of transcription 3	Homo sapiens	14-20
33955636-8	2021	Inhibition of STAT-3, p38, and ERK1/2 phosphorylation and modulation pro-apoptotic protein expression might be responsible for the anticancer activity of delphinidin in colon cancer cells.	delphinidin	154-165	mitogen-activated protein kinase 1	Homo sapiens	22-25
33955636-8	2021	Inhibition of STAT-3, p38, and ERK1/2 phosphorylation and modulation pro-apoptotic protein expression might be responsible for the anticancer activity of delphinidin in colon cancer cells.	delphinidin	154-165	mitogen-activated protein kinase 3	Homo sapiens	31-37
34712357-0	2021	Delphinidin induces cell cycle arrest and apoptosis in HER-2 positive breast cancer cell lines by regulating the NF-kappaB and MAPK signaling pathways.	delphinidin	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-60
34712357-0	2021	Delphinidin induces cell cycle arrest and apoptosis in HER-2 positive breast cancer cell lines by regulating the NF-kappaB and MAPK signaling pathways.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	113-122
34712357-0	2021	Delphinidin induces cell cycle arrest and apoptosis in HER-2 positive breast cancer cell lines by regulating the NF-kappaB and MAPK signaling pathways.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	127-131
34712357-1	2021	Delphinidin is an anthocyanidin monomer, commonly found in vegetables and fruits, and has demonstrated antitumor effects in the HER-2-positive MDA-MB-453 breast cancer cell line, with low cytotoxicity on normal breast cells.	delphinidin	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-133
34712357-2	2021	However, the direct functional mechanisms underlying the effect of delphinidin on HER-2-positive breast cancer cells has not been fully characterized.	delphinidin	67-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-87
34712357-3	2021	In the present study, it was found that delphinidin could induce G2/M phase cell cycle arrest by inhibiting the protein expression level of cyclin B1 and Cdk1 in HER-2-positive breast cancer cell lines.	delphinidin	40-51	cyclin B1	Homo sapiens	140-149
34712357-3	2021	In the present study, it was found that delphinidin could induce G2/M phase cell cycle arrest by inhibiting the protein expression level of cyclin B1 and Cdk1 in HER-2-positive breast cancer cell lines.	delphinidin	40-51	cyclin dependent kinase 1	Homo sapiens	154-158
34712357-3	2021	In the present study, it was found that delphinidin could induce G2/M phase cell cycle arrest by inhibiting the protein expression level of cyclin B1 and Cdk1 in HER-2-positive breast cancer cell lines.	delphinidin	40-51	erb-b2 receptor tyrosine kinase 2	Homo sapiens	162-167
34712357-4	2021	In addition, delphinidin promoted the mitochondrial apoptosis pathway by inhibiting the ERK and NF-kappaB signaling pathway and activating the JNK signaling pathway.	delphinidin	13-24	mitogen-activated protein kinase 1	Homo sapiens	88-91
34712357-4	2021	In addition, delphinidin promoted the mitochondrial apoptosis pathway by inhibiting the ERK and NF-kappaB signaling pathway and activating the JNK signaling pathway.	delphinidin	13-24	nuclear factor kappa B subunit 1	Homo sapiens	96-105
34712357-4	2021	In addition, delphinidin promoted the mitochondrial apoptosis pathway by inhibiting the ERK and NF-kappaB signaling pathway and activating the JNK signaling pathway.	delphinidin	13-24	mitogen-activated protein kinase 8	Homo sapiens	143-146
34712357-5	2021	Therefore, delphinidin markedly suppressed the viability of the HER-2-positive breast cancer cell lines by modulating the cell cycle and inducing apoptosis.	delphinidin	11-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-69
34712357-6	2021	Overall, the findings from the present study demonstrated that delphinidin treatment could induce the mitochondrial apoptosis pathway in human HER-2-positive breast cancer cell lines, providing an experimental basis for the prevention and treatment of HER-2-positive breast cancer by flavonoids.	delphinidin	63-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-148
34712357-6	2021	Overall, the findings from the present study demonstrated that delphinidin treatment could induce the mitochondrial apoptosis pathway in human HER-2-positive breast cancer cell lines, providing an experimental basis for the prevention and treatment of HER-2-positive breast cancer by flavonoids.	delphinidin	63-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	252-257
34825313-0	2022	Delphinidin diminishes in vitro interferon-gamma and interleukin-17 producing cells in patients with psoriatic disease.	delphinidin	0-11	interferon gamma	Homo sapiens	32-48
34825313-6	2022	Delphinidin dose-dependently reduced IFNgamma+ T cells from patients and HCs.	delphinidin	0-11	interferon gamma	Homo sapiens	37-45
34825313-9	2022	An inhibitory effect of delphinidin was also noted in IFNgamma producing NKs and NKTs from psoriasis individuals.	delphinidin	24-35	interferon gamma	Homo sapiens	54-62
34825313-10	2022	Delphinidin also significantly decreased IL-17+ CD4+ T cells in all tested subjects, with marginal effect on the increase of IL-10-producing T regulatory subsets.	delphinidin	0-11	interleukin 17A	Homo sapiens	41-46
34825313-10	2022	Delphinidin also significantly decreased IL-17+ CD4+ T cells in all tested subjects, with marginal effect on the increase of IL-10-producing T regulatory subsets.	delphinidin	0-11	CD4 molecule	Homo sapiens	48-51
34825313-11	2022	In conclusion, delphinidin exerts a profound in vitro anti-inflammatory effect in psoriasis and psoriatic arthritis by inhibiting IFNgamma+ innate and adaptive cells and T helper (Th) 17 cells.	delphinidin	15-26	interferon gamma	Homo sapiens	130-138
35164310-6	2022	Among the flavan-3-ols recognized as substrates, (+)-gallocatechin was only transformed into delphinidin by VvANS, whereas (+)-catechin was transformed into three products, including two major products that were an ascorbate-cyanidin adduct and a dimer of oxidized catechin, and a minor product that was cyanidin.	delphinidin	93-104	leucoanthocyanidin dioxygenase	Vitis vinifera	108-113
32155282-5	2021	Using live imaging in medaka bone reporter lines, we show that delphinidin significantly reduces the number of osteoclasts after Rankl induction and protects bone integrity in a dose-dependent manner.	delphinidin	63-74	tumor necrosis factor ligand superfamily member 11	Oryzias latipes	129-134
32830148-0	2020	Delphinidin enhances radio-therapeutic effects via autophagy induction and JNK/MAPK pathway activation in non-small cell lung cancer.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	75-78
33693759-11	2021	In GLUTag cells, 1) cyanidin, delphinidin, PCA, and EC increased GLP-1 secretion (53%, 33%, 53%, and 68%, respectively; P < 0.05); and 2) cyanidin, delphinidin, EC, and PCA increased cyclin adenosine monophosphate levels (25-50%; P < 0.05) and activated protein kinase A (PKA; 100%, 50%, 80%, and 86%, respectively; P < 0.05).	delphinidin	30-41	glucagon	Mus musculus	65-70
33274001-4	2020	At the same time, the expression of Nrf2 was enhanced by the delphinidin pretreatment.	delphinidin	61-72	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
33274001-6	2020	Besides, we found that delphinidin could significantly alleviate the reduction of Nrf2 protein levels and the accumulation of intracellular ROS levels in Nrf2 knockdown HepG2 cells.	delphinidin	23-34	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
33274001-6	2020	Besides, we found that delphinidin could significantly alleviate the reduction of Nrf2 protein levels and the accumulation of intracellular ROS levels in Nrf2 knockdown HepG2 cells.	delphinidin	23-34	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33274001-7	2020	In conclusion, our study suggested that delphinidin, as an effective antioxidant, protected HepG2 cells from oxidative stress by regulating the expression of Nrf2/HO-1.	delphinidin	40-51	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
33274001-7	2020	In conclusion, our study suggested that delphinidin, as an effective antioxidant, protected HepG2 cells from oxidative stress by regulating the expression of Nrf2/HO-1.	delphinidin	40-51	heme oxygenase 1	Homo sapiens	163-167
33083375-6	2020	Indeed, delphinidin inhibits alpha-glucosidase in a mixed type, close to non-competitive manner with an inhibitory constant of 78 nM.	delphinidin	8-19	sucrase-isomaltase	Homo sapiens	29-46
33693759-13	2021	Cyanidin, delphinidin, PCA, and EC promoted GLP-1 secretion from GLUTag cells by activating the PKA-dependent pathway.	delphinidin	10-21	glucagon	Mus musculus	44-49
32830148-6	2020	Moreover, combined treatment with delphinidin and IR, enhanced apoptotic cell death, suppressed the mTOR pathway, and activated the JNK/MAPK pathway.	delphinidin	34-45	mechanistic target of rapamycin kinase	Homo sapiens	100-104
32830148-6	2020	Moreover, combined treatment with delphinidin and IR, enhanced apoptotic cell death, suppressed the mTOR pathway, and activated the JNK/MAPK pathway.	delphinidin	34-45	mitogen-activated protein kinase 8	Homo sapiens	132-135
32830148-7	2020	Delphinidin inhibited the phosphorylation of PI3K, AKT, and mTOR, and increased the expression of autophagy-induced cell death associated-protein in radiation-exposed NSCLC cells.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	51-54
32830148-7	2020	Delphinidin inhibited the phosphorylation of PI3K, AKT, and mTOR, and increased the expression of autophagy-induced cell death associated-protein in radiation-exposed NSCLC cells.	delphinidin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	60-64
32830148-8	2020	In addition, JNK phosphorylation was upregulated by delphinidin pre-treatment in radiation-exposed NSCLC cells.	delphinidin	52-63	mitogen-activated protein kinase 8	Homo sapiens	13-16
32830148-9	2020	Collectively, these results show that delphinidin acts as a radiation-sensitizing agent through autophagy induction and JNK/MAPK pathway activation, thus enhancing apoptotic cell death in NSCLC cells.	delphinidin	38-49	mitogen-activated protein kinase 8	Homo sapiens	120-123
31831830-0	2019	Dietary delphinidin inhibits human colorectal cancer metastasis associating with upregulation of miR-204-3p and suppression of the integrin/FAK axis.	delphinidin	8-19	protein tyrosine kinase 2	Homo sapiens	140-143
32209725-0	2020	Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway.	delphinidin	0-11	mitogen-activated protein kinase 1	Mus musculus	73-77
32209725-7	2020	Through analyses of hypertrophic cardiomyocyte growth, fibrosis and cardiac function, delphinidin was demonstrated to confer resistance to aging- and transverse aortic constriction (TAC)-induced cardiac hypertrophy in vivo and attenuate Ang II-induced cardiomyocyte hypertrophy in vitro by significantly suppressing hypertrophic growth and the deposition of fibrosis.	delphinidin	86-97	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	237-243
32209725-8	2020	Mechanistically, delphinidin reduced ROS accumulation upon Ang II stimulation through the direct activation of AMP-activated protein kinase (AMPK) and subsequent inhibition of the activity of Rac1 and expression of p47phox.	delphinidin	17-28	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	59-65
32209725-8	2020	Mechanistically, delphinidin reduced ROS accumulation upon Ang II stimulation through the direct activation of AMP-activated protein kinase (AMPK) and subsequent inhibition of the activity of Rac1 and expression of p47phox.	delphinidin	17-28	Rac family small GTPase 1	Mus musculus	192-196
32209725-8	2020	Mechanistically, delphinidin reduced ROS accumulation upon Ang II stimulation through the direct activation of AMP-activated protein kinase (AMPK) and subsequent inhibition of the activity of Rac1 and expression of p47phox.	delphinidin	17-28	neutrophil cytosolic factor 1	Mus musculus	215-222
32209725-9	2020	In addition, excessive levels of ERK1/2, P38 and JNK1/2 phosphorylation induced by oxidative stress were abrogated by delphinidin.	delphinidin	118-129	mitogen-activated protein kinase 3	Mus musculus	33-39
32209725-9	2020	In addition, excessive levels of ERK1/2, P38 and JNK1/2 phosphorylation induced by oxidative stress were abrogated by delphinidin.	delphinidin	118-129	mitogen-activated protein kinase 14	Mus musculus	41-44
32209725-9	2020	In addition, excessive levels of ERK1/2, P38 and JNK1/2 phosphorylation induced by oxidative stress were abrogated by delphinidin.	delphinidin	118-129	mitogen-activated protein kinase 8	Mus musculus	49-53
32209725-10	2020	Delphinidin was conclusively shown to repress pathological cardiac hypertrophy by modulating oxidative stress through the AMPK/NADPH oxidase (NOX)/mitogen-activated protein kinase (MAPK) signaling pathway.	delphinidin	0-11	mitogen-activated protein kinase 1	Mus musculus	181-185
31963866-7	2020	Delphinidin inhibited reactive oxygen species (ROS)-induced apoptosis by significantly decreasing apoptosis markers such as c-caspase-3 and c-PARP while increasing antiapoptotic marker Bcl-XL and antioxidant response NF-kappaB and Nrf2 pathways.	delphinidin	0-11	BCL2 like 1	Homo sapiens	185-191
31963866-7	2020	Delphinidin inhibited reactive oxygen species (ROS)-induced apoptosis by significantly decreasing apoptosis markers such as c-caspase-3 and c-PARP while increasing antiapoptotic marker Bcl-XL and antioxidant response NF-kappaB and Nrf2 pathways.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	217-226
31963866-7	2020	Delphinidin inhibited reactive oxygen species (ROS)-induced apoptosis by significantly decreasing apoptosis markers such as c-caspase-3 and c-PARP while increasing antiapoptotic marker Bcl-XL and antioxidant response NF-kappaB and Nrf2 pathways.	delphinidin	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	231-235
31963866-10	2020	Delphinidin can protect chondrocytes against H2O2-induced apoptosis via activation of Nrf2 and NF-kappaB and protective autophagy.	delphinidin	0-11	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
31963866-10	2020	Delphinidin can protect chondrocytes against H2O2-induced apoptosis via activation of Nrf2 and NF-kappaB and protective autophagy.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	95-104
31781740-0	2019	Delphinidin-induced autophagy protects pancreatic beta cells against apoptosis resulting from high-glucose stress via AMPK signaling pathway.	delphinidin	0-11	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	118-122
31781740-2	2019	Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes.	delphinidin	0-11	glucagon	Rattus norvegicus	88-111
31781740-2	2019	Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes.	delphinidin	0-11	glucagon	Rattus norvegicus	113-118
32297026-8	2020	Our immunoblotting analysis confirmed high dose of Delphinidin reduced AChE, APP and Abeta contents in AD model.	delphinidin	51-62	acetylcholinesterase	Rattus norvegicus	71-75
32297026-8	2020	Our immunoblotting analysis confirmed high dose of Delphinidin reduced AChE, APP and Abeta contents in AD model.	delphinidin	51-62	amyloid beta precursor protein	Rattus norvegicus	85-90
32297026-10	2020	It seems that Delphinidin is a plate-like molecule intercalated between beta-plated sheets related to Abeta molecules and inhibited amyloid fibril formation.	delphinidin	14-25	amyloid beta precursor protein	Rattus norvegicus	102-107
31781740-7	2019	Compound C, an AMPK inhibitor, was found to decrease the ratio of LC3-II/LC3-I, and the apoptotic rate of high-glucose-injured cells was increased after treatment with delphinidin, indicating that delphinidin attenuated the negative effects of high-glucose stress to cells.	delphinidin	168-179	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	15-19
31781740-8	2019	In conclusion, our data demonstrate that delphinidin protects pancreatic beta cells against high-glucose-induced injury by autophagy regulation via the AMPK signaling pathway.	delphinidin	41-52	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	152-156
31831830-7	2019	Delphinidin also suppressed the migratory ability and invasiveness of the tested CRC cell lines, downregulated integrin alphaV/beta3 expression, inhibited focal adhesion kinase (FAK)/Src/paxillin signaling, and interfered with cytoskeletal construction.	delphinidin	0-11	integrin subunit alpha V	Homo sapiens	111-132
31831830-7	2019	Delphinidin also suppressed the migratory ability and invasiveness of the tested CRC cell lines, downregulated integrin alphaV/beta3 expression, inhibited focal adhesion kinase (FAK)/Src/paxillin signaling, and interfered with cytoskeletal construction.	delphinidin	0-11	protein tyrosine kinase 2	Homo sapiens	155-176
31831830-7	2019	Delphinidin also suppressed the migratory ability and invasiveness of the tested CRC cell lines, downregulated integrin alphaV/beta3 expression, inhibited focal adhesion kinase (FAK)/Src/paxillin signaling, and interfered with cytoskeletal construction.	delphinidin	0-11	protein tyrosine kinase 2	Homo sapiens	178-181
31831830-7	2019	Delphinidin also suppressed the migratory ability and invasiveness of the tested CRC cell lines, downregulated integrin alphaV/beta3 expression, inhibited focal adhesion kinase (FAK)/Src/paxillin signaling, and interfered with cytoskeletal construction.	delphinidin	0-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	183-186
31831830-7	2019	Delphinidin also suppressed the migratory ability and invasiveness of the tested CRC cell lines, downregulated integrin alphaV/beta3 expression, inhibited focal adhesion kinase (FAK)/Src/paxillin signaling, and interfered with cytoskeletal construction.	delphinidin	0-11	paxillin	Homo sapiens	187-195
31831830-9	2019	Abolishing the expression of one upregulated miR, miR-204-3p, with an antagomir restored delphinidin-mediated inhibition of cell migration and invasiveness in DLD-1 cells as well as the alphaV/beta3-integrin/FAK/Src axis.	delphinidin	89-100	protein tyrosine kinase 2	Homo sapiens	208-211
31831830-9	2019	Abolishing the expression of one upregulated miR, miR-204-3p, with an antagomir restored delphinidin-mediated inhibition of cell migration and invasiveness in DLD-1 cells as well as the alphaV/beta3-integrin/FAK/Src axis.	delphinidin	89-100	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	212-215
31831830-11	2019	Collectively, these results indicate that the migration and invasion of CRC cells are inhibited by delphinidin, and the mechanism may involve the upregulation of miR-204-3p and consequent suppression of the alphaV/beta3-integrin/FAK axis.	delphinidin	99-110	protein tyrosine kinase 2	Homo sapiens	229-232
31831830-12	2019	These findings suggest that delphinidin exerts anti-metastatic effects in CRC cells by inhibiting integrin/FAK signaling and indicate that miR-204-3p may play an important role in CRC metastasis.	delphinidin	28-39	protein tyrosine kinase 2	Homo sapiens	107-110
30537288-0	2019	Delphinidin inhibits epidermal growth factor-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma cells.	delphinidin	0-11	epidermal growth factor	Homo sapiens	21-44
31557009-4	2019	Del and its glycosides can be the alternative inhibitors of CBRs, ERalpha/beta, EGFR, BCRP, and SGLT-1, and virtual docking indicates that the sugar moiety may not effectively interact with the active sites of the targets.	delphinidin	0-3	epidermal growth factor receptor	Homo sapiens	80-84
31557009-4	2019	Del and its glycosides can be the alternative inhibitors of CBRs, ERalpha/beta, EGFR, BCRP, and SGLT-1, and virtual docking indicates that the sugar moiety may not effectively interact with the active sites of the targets.	delphinidin	0-3	BCR pseudogene 1	Homo sapiens	86-90
31557009-4	2019	Del and its glycosides can be the alternative inhibitors of CBRs, ERalpha/beta, EGFR, BCRP, and SGLT-1, and virtual docking indicates that the sugar moiety may not effectively interact with the active sites of the targets.	delphinidin	0-3	solute carrier family 5 member 1	Homo sapiens	96-102
31325197-0	2019	Delphinidin suppresses breast carcinogenesis through the HOTAIR/microRNA-34a axis.	delphinidin	0-11	HOX transcript antisense RNA	Homo sapiens	57-63
31325197-2	2019	In this study, we investigated the effect of delphinidin on 1-methyl-1-nitrosourea (MNU)-induced breast carcinogenesis on rats and the mechanism of delphinidin via negative regulation of the HOTAIR/microRNA-34a axis.	delphinidin	148-159	HOX transcript antisense RNA	Homo sapiens	191-197
31325197-4	2019	Delphinidin downregulated the level of HOTAIR and upregulated miR-34a in breast carcinogenesis.	delphinidin	0-11	HOX transcript antisense RNA	Homo sapiens	39-45
31325197-4	2019	Delphinidin downregulated the level of HOTAIR and upregulated miR-34a in breast carcinogenesis.	delphinidin	0-11	microRNA 34a	Homo sapiens	62-69
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	catenin beta 1	Homo sapiens	104-116
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	glycogen synthase kinase 3 beta	Homo sapiens	118-148
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	glycogen synthase kinase 3 beta	Homo sapiens	150-158
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	161-166
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	cyclin D1	Homo sapiens	168-177
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	matrix metallopeptidase 7	Homo sapiens	183-209
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	matrix metallopeptidase 7	Homo sapiens	210-215
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	microRNA 34a	Homo sapiens	270-277
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	329-334
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	cyclin D1	Homo sapiens	336-345
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	matrix metallopeptidase 7	Homo sapiens	351-356
31827486-12	2019	Golden Glory expressing cauliflower mosaic virus 35S-driven PAP1 generated red flowers that accumulated delphinidin and its methylated derivatives, as compared to control yellow flowers in the GUS-expressing plants.	delphinidin	104-115	production of anthocyanin pigment 1	Arabidopsis thaliana	60-64
31325197-6	2019	HOTAIR overexpression also blocked the effect of delphinidin on miR-34a and the Wnt/beta-catenin signaling pathway in MDA-MB-231 cells.	delphinidin	49-60	HOX transcript antisense RNA	Homo sapiens	0-6
31325197-6	2019	HOTAIR overexpression also blocked the effect of delphinidin on miR-34a and the Wnt/beta-catenin signaling pathway in MDA-MB-231 cells.	delphinidin	49-60	microRNA 34a	Homo sapiens	64-71
31325197-6	2019	HOTAIR overexpression also blocked the effect of delphinidin on miR-34a and the Wnt/beta-catenin signaling pathway in MDA-MB-231 cells.	delphinidin	49-60	catenin beta 1	Homo sapiens	84-96
31325197-7	2019	RNA immunoprecipitation (RIP) assay and chromatin immunoprecipitation (ChIP) assay results showed that delphinidin upregulated miR-34a by inhibiting HOTAIR, coupled with enhancement of the zeste homolog 2 (EZH2) and histone H3 Lys27 trimethylation (H3K27me3).	delphinidin	103-114	microRNA 34a	Homo sapiens	127-134
31325197-7	2019	RNA immunoprecipitation (RIP) assay and chromatin immunoprecipitation (ChIP) assay results showed that delphinidin upregulated miR-34a by inhibiting HOTAIR, coupled with enhancement of the zeste homolog 2 (EZH2) and histone H3 Lys27 trimethylation (H3K27me3).	delphinidin	103-114	HOX transcript antisense RNA	Homo sapiens	149-155
31325197-7	2019	RNA immunoprecipitation (RIP) assay and chromatin immunoprecipitation (ChIP) assay results showed that delphinidin upregulated miR-34a by inhibiting HOTAIR, coupled with enhancement of the zeste homolog 2 (EZH2) and histone H3 Lys27 trimethylation (H3K27me3).	delphinidin	103-114	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	206-210
31325197-8	2019	This study indicated that delphinidin may potentially suppress breast carcinogenesis and exert its anti-cancer effect through the HOTAIR/miR-34a axis.	delphinidin	26-37	HOX transcript antisense RNA	Homo sapiens	130-136
31325197-8	2019	This study indicated that delphinidin may potentially suppress breast carcinogenesis and exert its anti-cancer effect through the HOTAIR/miR-34a axis.	delphinidin	26-37	microRNA 34a	Homo sapiens	137-144
31254216-0	2019	Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway.	delphinidin	12-23	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
31254216-9	2019	Overall, our results suggest that delphinidin, an epigenetic demethylating agent of the Nrf2 promoter, can activate the Nrf2-ARE pathway, which can be applied as a potential skin cancer chemopreventive agent.	delphinidin	34-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
31254216-9	2019	Overall, our results suggest that delphinidin, an epigenetic demethylating agent of the Nrf2 promoter, can activate the Nrf2-ARE pathway, which can be applied as a potential skin cancer chemopreventive agent.	delphinidin	34-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
30537288-7	2019	Based on the result of proliferation, to measure the effects of delphinidin on EGF-induced EMT, we designated a proper concentration of delphinidin, which is not affected to cell proliferation.	delphinidin	64-75	epidermal growth factor	Homo sapiens	79-82
30537288-7	2019	Based on the result of proliferation, to measure the effects of delphinidin on EGF-induced EMT, we designated a proper concentration of delphinidin, which is not affected to cell proliferation.	delphinidin	136-147	epidermal growth factor	Homo sapiens	79-82
30537288-8	2019	We found that delphinidin inhibits morphological changes from epithelial to mesenchymal phenotype by EGF.	delphinidin	14-25	epidermal growth factor	Homo sapiens	101-104
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	epidermal growth factor	Homo sapiens	57-60
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	matrix metallopeptidase 2	Homo sapiens	113-139
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	epidermal growth factor receptor	Homo sapiens	141-153
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	epidermal growth factor receptor	Homo sapiens	155-159
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	AKT serine/threonine kinase 1	Homo sapiens	162-165
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	mitogen-activated protein kinase 1	Homo sapiens	171-208
30537288-10	2019	Also, delphinidin prevented motility and invasiveness of EGF-induced HCC cells through suppressing activation of matrix metalloproteinase 2, EGF receptor (EGFR), AKT, and extracellular signal-regulated kinase (ERK).	delphinidin	6-17	mitogen-activated protein kinase 1	Homo sapiens	210-213
30537288-11	2019	Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells.	delphinidin	46-57	epidermal growth factor	Homo sapiens	67-70
30537288-11	2019	Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells.	delphinidin	46-57	epidermal growth factor receptor	Homo sapiens	97-101
30537288-11	2019	Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells.	delphinidin	46-57	AKT serine/threonine kinase 1	Homo sapiens	102-105
30537288-11	2019	Taken together, our findings demonstrate that delphinidin inhibits EGF-induced EMT by inhibiting EGFR/AKT/ERK signaling pathway in HCC cells.	delphinidin	46-57	mitogen-activated protein kinase 1	Homo sapiens	106-109
30865689-11	2019	Delphinidin, an anthocyanin abundant in DIAVIT, increased the VEGF-A165b expression relative to total VEGF-A165 in cultured podocytes through phosphorylation of the splice factor SRSF6.	delphinidin	0-11	serine and arginine-rich splicing factor 6	Mus musculus	179-184
30864408-2	2019	In this study, we have demonstrated the capacity of delphinidin and luteolin to increase human telomerase reverse transcriptase (hTERT) expression level and act as protective agents against halogenated boroxine-induced genotoxic damage.	delphinidin	52-63	telomerase reverse transcriptase	Homo sapiens	95-127
30864408-2	2019	In this study, we have demonstrated the capacity of delphinidin and luteolin to increase human telomerase reverse transcriptase (hTERT) expression level and act as protective agents against halogenated boroxine-induced genotoxic damage.	delphinidin	52-63	telomerase reverse transcriptase	Homo sapiens	129-134
30320921-6	2019	Additionally, treatment with delphinidin decreased the mitochondrial membrane potential and increased cytosolic calcium levels in VK2/E6E7 and End1/E6E7 cells.	delphinidin	29-40	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	143-147
30320921-7	2019	Delphinidin decreased the phosphorylation of proliferative signaling molecules, including ERK1/2, AKT, P70S6K, and S6, while increasing the phosphorylation of P38 MAPK and P90RSK.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	90-96
30320921-7	2019	Delphinidin decreased the phosphorylation of proliferative signaling molecules, including ERK1/2, AKT, P70S6K, and S6, while increasing the phosphorylation of P38 MAPK and P90RSK.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	98-101
30320921-7	2019	Delphinidin decreased the phosphorylation of proliferative signaling molecules, including ERK1/2, AKT, P70S6K, and S6, while increasing the phosphorylation of P38 MAPK and P90RSK.	delphinidin	0-11	ribosomal protein S6 kinase B1	Homo sapiens	103-109
30320921-7	2019	Delphinidin decreased the phosphorylation of proliferative signaling molecules, including ERK1/2, AKT, P70S6K, and S6, while increasing the phosphorylation of P38 MAPK and P90RSK.	delphinidin	0-11	ribosomal protein S6 kinase A1	Homo sapiens	172-178
30865689-12	2019	DIAVIT, in particular delphinidin, alters VEGF-A splicing in type II DN, rescuing the DN phenotype.	delphinidin	22-33	vascular endothelial growth factor A	Mus musculus	42-48
29451351-0	2018	Delphinidin induces apoptosis and inhibits epithelial-to-mesenchymal transition via the ERK/p38 MAPK-signaling pathway in human osteosarcoma cell lines.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	88-91
30668416-11	2019	RESULTS: Delphinidin inhibited MSC adipogenesis and downregulated FABP4 and adiponectin genes.	delphinidin	9-20	fatty acid binding protein 4	Homo sapiens	66-71
30668416-11	2019	RESULTS: Delphinidin inhibited MSC adipogenesis and downregulated FABP4 and adiponectin genes.	delphinidin	9-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	76-87
30668416-13	2019	Cyanidin and delphinidin demonstrated a chondrogenesis stimulating effect by upregulation of Col2a1 and aggrecan.	delphinidin	13-24	collagen type II alpha 1 chain	Homo sapiens	93-99
30125548-4	2018	The induction of apoptosis as evidenced by the increase of sub-G1 cells, DNA fragmentation, annexin V-positive cells and the activation of caspase-8, -9 and -3 was observed in HL-60 cells co-treated with As(III) and delphinidin.	delphinidin	216-227	caspase 8	Homo sapiens	139-159
30365941-0	2019	Delphinidin protects beta2m-/Thy1+ bone marrow-derived hepatocyte stem cells against TGF-beta1-induced oxidative stress and apoptosis through the PI3K/Akt pathway in vitro.	delphinidin	0-11	Thy-1 cell surface antigen	Homo sapiens	29-33
30365941-0	2019	Delphinidin protects beta2m-/Thy1+ bone marrow-derived hepatocyte stem cells against TGF-beta1-induced oxidative stress and apoptosis through the PI3K/Akt pathway in vitro.	delphinidin	0-11	transforming growth factor beta 1	Homo sapiens	85-94
30365941-0	2019	Delphinidin protects beta2m-/Thy1+ bone marrow-derived hepatocyte stem cells against TGF-beta1-induced oxidative stress and apoptosis through the PI3K/Akt pathway in vitro.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	151-154
30365941-7	2019	In the present research, we determined whether delphinidin pretreatment can improve the survival of beta2m-/Thy1+ BDHSCs during exposure to TGF-beta1 and elucidated its underlying mechanisms.	delphinidin	47-58	Thy-1 cell surface antigen	Homo sapiens	108-112
30365941-7	2019	In the present research, we determined whether delphinidin pretreatment can improve the survival of beta2m-/Thy1+ BDHSCs during exposure to TGF-beta1 and elucidated its underlying mechanisms.	delphinidin	47-58	transforming growth factor beta 1	Homo sapiens	140-149
30365941-11	2019	We found that delphinidin can significantly impede TGF-beta1-induced apoptosis dose-dependently, scavenge reactive oxygen species (ROS), and inhibit the discharge of caspase-3 in beta2m-/Thy1+ BDHSCs.	delphinidin	14-25	transforming growth factor beta 1	Homo sapiens	51-60
30365941-11	2019	We found that delphinidin can significantly impede TGF-beta1-induced apoptosis dose-dependently, scavenge reactive oxygen species (ROS), and inhibit the discharge of caspase-3 in beta2m-/Thy1+ BDHSCs.	delphinidin	14-25	caspase 3	Homo sapiens	166-175
30365941-11	2019	We found that delphinidin can significantly impede TGF-beta1-induced apoptosis dose-dependently, scavenge reactive oxygen species (ROS), and inhibit the discharge of caspase-3 in beta2m-/Thy1+ BDHSCs.	delphinidin	14-25	Thy-1 cell surface antigen	Homo sapiens	187-191
30365941-12	2019	We also demonstrated that delphinidin can activate the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	delphinidin	26-37	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	55-84
30365941-12	2019	We also demonstrated that delphinidin can activate the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	delphinidin	26-37	AKT serine/threonine kinase 1	Homo sapiens	92-95
30365941-14	2019	In summary, our findings revealed that delphinidin can protect beta2m-/Thy1+ BDHSCs from apoptosis and ROS-dependent oxidative stress induced by the TGF-beta1 via PI3K/Akt signaling pathway.	delphinidin	39-50	Thy-1 cell surface antigen	Homo sapiens	71-75
30365941-14	2019	In summary, our findings revealed that delphinidin can protect beta2m-/Thy1+ BDHSCs from apoptosis and ROS-dependent oxidative stress induced by the TGF-beta1 via PI3K/Akt signaling pathway.	delphinidin	39-50	transforming growth factor beta 1	Homo sapiens	149-158
30365941-14	2019	In summary, our findings revealed that delphinidin can protect beta2m-/Thy1+ BDHSCs from apoptosis and ROS-dependent oxidative stress induced by the TGF-beta1 via PI3K/Akt signaling pathway.	delphinidin	39-50	AKT serine/threonine kinase 1	Homo sapiens	168-171
30365941-15	2019	On the basis of these data, delphinidin can be regarded as a promising anti-apoptotic agent for enhancing beta2m-/Thy1+ BDHSC survival during cell transplantation in liver cirrhosis patients.	delphinidin	28-39	Thy-1 cell surface antigen	Homo sapiens	114-118
30103390-3	2018	Cells incubated with palmitate to induce lipid accumulation, concomitantly treated with Dp, reduced triglyceride accumulation by ~53%, and downregulated gene expression of CPT1A, SREBF1, and FASN without modifying AMP-activated protein kinase (AMPK) levels.	delphinidin	88-90	carnitine palmitoyltransferase 1A	Homo sapiens	172-177
30103390-3	2018	Cells incubated with palmitate to induce lipid accumulation, concomitantly treated with Dp, reduced triglyceride accumulation by ~53%, and downregulated gene expression of CPT1A, SREBF1, and FASN without modifying AMP-activated protein kinase (AMPK) levels.	delphinidin	88-90	sterol regulatory element binding transcription factor 1	Homo sapiens	179-185
30103390-3	2018	Cells incubated with palmitate to induce lipid accumulation, concomitantly treated with Dp, reduced triglyceride accumulation by ~53%, and downregulated gene expression of CPT1A, SREBF1, and FASN without modifying AMP-activated protein kinase (AMPK) levels.	delphinidin	88-90	fatty acid synthase	Homo sapiens	191-195
29451351-0	2018	Delphinidin induces apoptosis and inhibits epithelial-to-mesenchymal transition via the ERK/p38 MAPK-signaling pathway in human osteosarcoma cell lines.	delphinidin	0-11	mitogen-activated protein kinase 14	Homo sapiens	92-95
29451351-10	2018	Furthermore, delphinidin treatment resulted in a profound reduction of phosphorylated forms of ERK and p38.	delphinidin	13-24	mitogen-activated protein kinase 1	Homo sapiens	95-98
29451351-10	2018	Furthermore, delphinidin treatment resulted in a profound reduction of phosphorylated forms of ERK and p38.	delphinidin	13-24	mitogen-activated protein kinase 14	Homo sapiens	103-106
29451351-11	2018	These findings demonstrate that delphinidin treatment suppressed EMT through the mitogen-activated protein kinase (MAPK) signaling pathway in OS cell lines.	delphinidin	32-43	mitogen-activated protein kinase 1	Homo sapiens	115-119
29451351-13	2018	Delphinidin treatment also suppresses cell migration and prevents EMT via the MAPK-signaling pathway in OS cell lines.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	78-82
29068672-8	2017	Delphinidin chloride reduced DBP-DNA adduct levels in MSK cells, while PGA did not.	delphinidin	0-20	D-box binding PAR bZIP transcription factor	Rattus norvegicus	29-32
29587684-0	2018	Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells.	delphinidin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	45-49
29587684-0	2018	Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells.	delphinidin	0-11	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	74-78
29587684-0	2018	Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells.	delphinidin	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	101-106
29587684-2	2018	In this study, we explored the biological activities of delphinidin, the most common of the anthocyanidin monomers, that were related to autophagy in HER-2 positive breast cancer MDA-MB-453 and BT474 cells.	delphinidin	56-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-155
29587684-7	2018	The inhibition of autophagy enhanced the delphinidin-induced apoptosis and antiproliferative effect in both HER-2 positive breast cancer cells.	delphinidin	41-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-113
29587684-8	2018	In addition, delphinidin induced autophagy via suppression of the mTOR signalling pathway and activation of the AMPK signalling pathway in HER-2 positive breast cancer cells.	delphinidin	13-24	mechanistic target of rapamycin kinase	Homo sapiens	66-70
29587684-8	2018	In addition, delphinidin induced autophagy via suppression of the mTOR signalling pathway and activation of the AMPK signalling pathway in HER-2 positive breast cancer cells.	delphinidin	13-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	112-116
29587684-8	2018	In addition, delphinidin induced autophagy via suppression of the mTOR signalling pathway and activation of the AMPK signalling pathway in HER-2 positive breast cancer cells.	delphinidin	13-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-144
29587684-9	2018	CONCLUSIONS: Collectively, the results showed that delphinidin induced apoptosis and autophagy in HER-2 positive breast cancer cells and that autophagy was induced via the mTOR and AMPK signalling pathways.	delphinidin	51-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-103
29587684-9	2018	CONCLUSIONS: Collectively, the results showed that delphinidin induced apoptosis and autophagy in HER-2 positive breast cancer cells and that autophagy was induced via the mTOR and AMPK signalling pathways.	delphinidin	51-62	mechanistic target of rapamycin kinase	Homo sapiens	172-176
29587684-9	2018	CONCLUSIONS: Collectively, the results showed that delphinidin induced apoptosis and autophagy in HER-2 positive breast cancer cells and that autophagy was induced via the mTOR and AMPK signalling pathways.	delphinidin	51-62	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	181-185
30727871-2	2018	It has also been highlighted that Dp interacts directly with the active site of estrogen receptor alpha (ERalpha), leading to activation of endothelial NO synthase (eNOS) pathway thus contributing to the prevention of endothelial dysfunction in mice aorta.	delphinidin	34-36	estrogen receptor 1 (alpha)	Mus musculus	80-103
30727871-2	2018	It has also been highlighted that Dp interacts directly with the active site of estrogen receptor alpha (ERalpha), leading to activation of endothelial NO synthase (eNOS) pathway thus contributing to the prevention of endothelial dysfunction in mice aorta.	delphinidin	34-36	estrogen receptor 1 (alpha)	Mus musculus	105-112
30727871-4	2018	OBJECTIVE: The aim of this study was to identify new Dp analogues with increased lipophilicity and vasorelaxation potential by a chemical modulation of its structure and to characterize the signaling pathway notably in relation with ERalpha signaling and nitric oxide (NO) production.	delphinidin	53-55	estrogen receptor 1 (alpha)	Mus musculus	233-240
29286333-5	2017	In silico docking analysis of cyanidin and delphinidin, the core portions of the compound that fits within the ligand-binding pocket of ERbeta, showed that similarly to 17beta-estradiol, hydrogen bonds formed with the ERbeta residues Glu305, Arg346, and His475.	delphinidin	43-54	estrogen receptor 2	Homo sapiens	136-142
29286333-5	2017	In silico docking analysis of cyanidin and delphinidin, the core portions of the compound that fits within the ligand-binding pocket of ERbeta, showed that similarly to 17beta-estradiol, hydrogen bonds formed with the ERbeta residues Glu305, Arg346, and His475.	delphinidin	43-54	estrogen receptor 2	Homo sapiens	218-224
28839227-0	2017	Estrogen receptor alpha/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks.	delphinidin	43-54	estrogen receptor 1	Homo sapiens	0-23
29285096-8	2017	Finally, treatment with delphinidin significantly inhibited NF-kappaB stimulation, COX-2 activity, PGE2 production, and AP-1 and p38-MAPK protein expression in SCI rats.	delphinidin	24-35	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	83-88
29285096-8	2017	Finally, treatment with delphinidin significantly inhibited NF-kappaB stimulation, COX-2 activity, PGE2 production, and AP-1 and p38-MAPK protein expression in SCI rats.	delphinidin	24-35	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-124
29285096-8	2017	Finally, treatment with delphinidin significantly inhibited NF-kappaB stimulation, COX-2 activity, PGE2 production, and AP-1 and p38-MAPK protein expression in SCI rats.	delphinidin	24-35	mitogen activated protein kinase 14	Rattus norvegicus	129-132
29285096-9	2017	These results suggest that the anti-inflammatory effect of delphinidin alleviated inflammation in the SCI rat model via alleviation of the intramedullary spinal pressure through the NF-kappaB and p38-MAPK signaling pathways.	delphinidin	59-70	mitogen activated protein kinase 14	Rattus norvegicus	196-199
28393456-7	2017	Correlation analysis identified potential blackcurrant polyphenolic anthocyanin constituents specifically delphinidins and cyanidins, involved in CCL11 suppression.	delphinidin	106-118	C-C motif chemokine ligand 11	Homo sapiens	146-151
29122484-0	2017	Delphinidin inhibits BDNF-induced migration and invasion in SKOV3 ovarian cancer cells.	delphinidin	0-11	brain derived neurotrophic factor	Homo sapiens	21-25
29122484-7	2017	Here, we found that delphinidin prominently inhibited the BDNF-induced increase in cell migration and invasion of SKOV3 ovarian cancer cells.	delphinidin	20-31	brain derived neurotrophic factor	Homo sapiens	58-62
29122484-8	2017	Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9.	delphinidin	13-24	brain derived neurotrophic factor	Homo sapiens	46-50
29122484-8	2017	Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9.	delphinidin	13-24	matrix metallopeptidase 2	Homo sapiens	76-81
29122484-8	2017	Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9.	delphinidin	13-24	matrix metallopeptidase 9	Homo sapiens	86-91
29122484-9	2017	Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-kappaB permitted by the BDNF in SKOV3 ovarian cancer cells.	delphinidin	6-17	AKT serine/threonine kinase 1	Homo sapiens	53-56
29122484-9	2017	Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-kappaB permitted by the BDNF in SKOV3 ovarian cancer cells.	delphinidin	6-17	brain derived neurotrophic factor	Homo sapiens	113-117
29122484-10	2017	Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation.	delphinidin	55-66	brain derived neurotrophic factor	Homo sapiens	82-86
29122484-10	2017	Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation.	delphinidin	55-66	AKT serine/threonine kinase 1	Homo sapiens	155-158
28839227-1	2017	Delphinidin, an anthocyanin present in red wine, has been reported to preserve the integrity of endothelium via an estrogen receptor alpha (ERalpha)-dependent mechanism.	delphinidin	0-11	estrogen receptor 1	Homo sapiens	115-138
28839227-1	2017	Delphinidin, an anthocyanin present in red wine, has been reported to preserve the integrity of endothelium via an estrogen receptor alpha (ERalpha)-dependent mechanism.	delphinidin	0-11	estrogen receptor 1	Homo sapiens	140-147
28839227-6	2017	Delphinidin also inhibited ERK1/2 activation.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	27-33
28839227-7	2017	Pharmacological inhibition of ER with fulvestrant, or deletion of ERalpha, prevented the effect of delphinidin.	delphinidin	99-110	estrogen receptor 1	Homo sapiens	66-73
28839227-8	2017	Further, delphinidin suppressed the differentiation of T cells toward Th1, Th17 and Treg without affecting Th2 subsets.	delphinidin	9-20	negative elongation factor complex member C/D	Homo sapiens	70-73
28839227-10	2017	Together, we propose that delphinidin, by acting on ERalpha via multiple cellular targets, may represent a new approach against chronic inflammation associated with T lymphocyte activation, proliferation and differentiation, in patients with cardiovascular risk factors.	delphinidin	26-37	estrogen receptor 1	Homo sapiens	52-59
28379159-8	2017	Taken together, our results suggest a new GPR-40 mediated local mechanism of action for delphinidin over intestinal cells that may in part explain its antidiabetic effect.	delphinidin	88-99	free fatty acid receptor 1	Homo sapiens	42-48
28740990-5	2017	In the range of concentrations tested (0.25-1 muM), O-glucosides of cyanidin, and delphinidin, but not those of malvidin, peonidin and petunidin protected the monolayer from TNFalpha-induced decrease of TEER and increase of FITC-dextran permeability.	delphinidin	82-93	tumor necrosis factor	Homo sapiens	174-182
28740990-6	2017	Cyanidin and delphinidin acted by mitigating TNFalpha-triggered activation of transcription factor NF-kappaB, and downstream phosphorylation of myosin light chain (MLC).	delphinidin	13-24	tumor necrosis factor	Homo sapiens	45-53
28740990-6	2017	Cyanidin and delphinidin acted by mitigating TNFalpha-triggered activation of transcription factor NF-kappaB, and downstream phosphorylation of myosin light chain (MLC).	delphinidin	13-24	nuclear factor kappa B subunit 1	Homo sapiens	99-108
28740990-6	2017	Cyanidin and delphinidin acted by mitigating TNFalpha-triggered activation of transcription factor NF-kappaB, and downstream phosphorylation of myosin light chain (MLC).	delphinidin	13-24	modulator of VRAC current 1	Homo sapiens	144-162
28740990-6	2017	Cyanidin and delphinidin acted by mitigating TNFalpha-triggered activation of transcription factor NF-kappaB, and downstream phosphorylation of myosin light chain (MLC).	delphinidin	13-24	modulator of VRAC current 1	Homo sapiens	164-167
28740990-7	2017	The protective actions of the ACRE on TNFalpha-induced TEER increase was positively correlated with the sum of cyanidins and delphinidins (r2 = 0.83) content in the ACRE.	delphinidin	125-137	tumor necrosis factor	Homo sapiens	38-46
28740990-9	2017	Results support a particular capacity of cyanidins and delphinidins in the protection of the intestinal barrier against inflammation-induced permeabilization, in part through the inhibition of the NF-kappaB pathway.	delphinidin	55-67	nuclear factor kappa B subunit 1	Homo sapiens	197-206
28693237-0	2017	Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction.	delphinidin	22-33	AKT serine/threonine kinase 1	Homo sapiens	88-91
28693237-0	2017	Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction.	delphinidin	22-33	mitogen-activated protein kinase 3	Homo sapiens	96-103
28693237-0	2017	Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction.	delphinidin	22-33	mitogen-activated protein kinase 3	Homo sapiens	104-108
28693237-5	2017	The levels of phosphorylated protein kinase B (AKT), ribosomal protein S6 kinase beta-1 (P70S6K), ribosomal protein S (S6), extracellular signal-regulated kinase (ERK)1/2 and p38 were suppressed by increasing concentrations of delphinidin.	delphinidin	227-238	mitogen-activated protein kinase 1	Homo sapiens	124-170
28693237-8	2017	These results indicate that delphinidin inhibits the proliferation of SKOV3 cells through inactivation of PI3K/AKT and ERK1/2 mitogen-activated protein kinase signaling cascades, and that this cell signaling pathway may be a pivotal therapeutic target for the prevention of epithelial ovarian cancer, including paclitaxel-resistant ovarian cancer.	delphinidin	28-39	AKT serine/threonine kinase 1	Homo sapiens	111-114
28693237-8	2017	These results indicate that delphinidin inhibits the proliferation of SKOV3 cells through inactivation of PI3K/AKT and ERK1/2 mitogen-activated protein kinase signaling cascades, and that this cell signaling pathway may be a pivotal therapeutic target for the prevention of epithelial ovarian cancer, including paclitaxel-resistant ovarian cancer.	delphinidin	28-39	mitogen-activated protein kinase 3	Homo sapiens	119-125
28379159-0	2017	Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40.	delphinidin	0-11	free fatty acid receptor 1	Homo sapiens	99-103
28379159-0	2017	Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40.	delphinidin	0-11	free fatty acid receptor 1	Homo sapiens	104-109
28379159-5	2017	By the use of specific pharmacological antagonists, we determined that delphinidin inhibits glucose absorption in both mouse jejunum and a human enterocytic cell line in a FFA1-dependent manner.	delphinidin	71-82	free fatty acid receptor 1	Homo sapiens	172-176
28379159-6	2017	Delphinidin also affects the function of sodium-glucose cotransporter 1 (SGLT1).	delphinidin	0-11	solute carrier family 5 member 1	Homo sapiens	41-71
28379159-6	2017	Delphinidin also affects the function of sodium-glucose cotransporter 1 (SGLT1).	delphinidin	0-11	solute carrier family 5 member 1	Homo sapiens	73-78
28364098-0	2017	[Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway].	delphinidin	1-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-39
28364098-0	2017	[Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway].	delphinidin	1-12	AKT serine/threonine kinase 1	Homo sapiens	79-82
28364098-0	2017	[Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway].	delphinidin	1-12	mechanistic target of rapamycin kinase	Homo sapiens	83-87
28364098-2	2017	:  Methods: Human epidermal growth factor receptor-2 (HER-2) positive breast cancer cells MDA-MB-453 were treated by delphinidin.	delphinidin	117-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-52
28364098-2	2017	:  Methods: Human epidermal growth factor receptor-2 (HER-2) positive breast cancer cells MDA-MB-453 were treated by delphinidin.	delphinidin	117-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-59
28364098-7	2017	Delphinidin downregulated the expression of caspase-3 and caspase-9, while upregulated the expression of cleaved caspase-3 and cleaved caspase-9 in a dose-dependent manner.	delphinidin	0-11	caspase 3	Homo sapiens	44-53
28364098-7	2017	Delphinidin downregulated the expression of caspase-3 and caspase-9, while upregulated the expression of cleaved caspase-3 and cleaved caspase-9 in a dose-dependent manner.	delphinidin	0-11	caspase 9	Homo sapiens	58-67
28364098-7	2017	Delphinidin downregulated the expression of caspase-3 and caspase-9, while upregulated the expression of cleaved caspase-3 and cleaved caspase-9 in a dose-dependent manner.	delphinidin	0-11	caspase 3	Homo sapiens	113-122
28364098-7	2017	Delphinidin downregulated the expression of caspase-3 and caspase-9, while upregulated the expression of cleaved caspase-3 and cleaved caspase-9 in a dose-dependent manner.	delphinidin	0-11	caspase 9	Homo sapiens	135-144
28364098-8	2017	Delphinidin enhanced the number of GFP-LC3 punctate dots, LC3 immunofluorescence dots and the expression of LC3-II and ATG5.	delphinidin	0-11	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	39-42
28364098-8	2017	Delphinidin enhanced the number of GFP-LC3 punctate dots, LC3 immunofluorescence dots and the expression of LC3-II and ATG5.	delphinidin	0-11	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	58-61
28364098-8	2017	Delphinidin enhanced the number of GFP-LC3 punctate dots, LC3 immunofluorescence dots and the expression of LC3-II and ATG5.	delphinidin	0-11	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	58-61
28364098-8	2017	Delphinidin enhanced the number of GFP-LC3 punctate dots, LC3 immunofluorescence dots and the expression of LC3-II and ATG5.	delphinidin	0-11	autophagy related 5	Homo sapiens	119-123
28364098-9	2017	Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k.	delphinidin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	52-56
28364098-9	2017	Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	86-89
28364098-9	2017	Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k.	delphinidin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	91-95
28364098-9	2017	Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k.	delphinidin	0-11	eukaryotic translation initiation factor 4E	Homo sapiens	97-102
28364098-9	2017	Delphinidin inhibited the expression of proteins in mTOR signaling pathway, including AKT, mTOR, eIF4E and p70s6k.	delphinidin	0-11	ribosomal protein S6 kinase B1	Homo sapiens	107-113
28364098-10	2017	:  Conclusion: Delphinidin induced apoptosis and autophagy by inhibition of AKT/mTOR pathway in HER positive breast cancer cells.	delphinidin	15-26	AKT serine/threonine kinase 1	Homo sapiens	76-79
28364098-10	2017	:  Conclusion: Delphinidin induced apoptosis and autophagy by inhibition of AKT/mTOR pathway in HER positive breast cancer cells.	delphinidin	15-26	mechanistic target of rapamycin kinase	Homo sapiens	80-84
27649384-7	2017	Dp was the most potent EMT inhibitor through its inhibitory effect on the TGF-beta Smad and non-Smad signaling pathways.	delphinidin	0-2	transforming growth factor beta 1	Homo sapiens	74-82
27390740-0	2016	Suppression of beta-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin.	delphinidin	84-95	catenin beta 1	Homo sapiens	15-27
27959445-0	2017	Delphinidin inhibits angiogenesis through the suppression of HIF-1alpha and VEGF expression in A549 lung cancer cells.	delphinidin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
27959445-0	2017	Delphinidin inhibits angiogenesis through the suppression of HIF-1alpha and VEGF expression in A549 lung cancer cells.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	76-80
27959445-2	2017	In the present study, we investigated the inhibitory effects of delphinidin on vascular endothelial growth factor (VEGF) expression, an important factor involved in angiogenesis and tumor progression, in A549 human lung cancer cells.	delphinidin	64-75	vascular endothelial growth factor A	Homo sapiens	79-113
27959445-2	2017	In the present study, we investigated the inhibitory effects of delphinidin on vascular endothelial growth factor (VEGF) expression, an important factor involved in angiogenesis and tumor progression, in A549 human lung cancer cells.	delphinidin	64-75	vascular endothelial growth factor A	Homo sapiens	115-119
27959445-3	2017	Delphinidin inhibited CoCl2- and epidermal growth factor (EGF)-induced VEGF mRNA expression and VEGF protein production.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	71-75
27959445-3	2017	Delphinidin inhibited CoCl2- and epidermal growth factor (EGF)-induced VEGF mRNA expression and VEGF protein production.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	96-100
27959445-4	2017	Delphinidin also decreased CoCl2- and EGF-stimulated expression of hypoxia-inducible factor (HIF)-1alpha, which is a transcription factor of VEGF.	delphinidin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-104
27959445-4	2017	Delphinidin also decreased CoCl2- and EGF-stimulated expression of hypoxia-inducible factor (HIF)-1alpha, which is a transcription factor of VEGF.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	141-145
27959445-5	2017	Delphinidin suppressed CoCl2- and EGF-induced hypoxia-response element (HRE) promoter activity, suggesting that the inhibitory effects of delphinidin on VEGF expression are caused by the suppression of the binding of HIF-1 to the HRE promoter.	delphinidin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-222
27959445-5	2017	Delphinidin suppressed CoCl2- and EGF-induced hypoxia-response element (HRE) promoter activity, suggesting that the inhibitory effects of delphinidin on VEGF expression are caused by the suppression of the binding of HIF-1 to the HRE promoter.	delphinidin	138-149	vascular endothelial growth factor A	Homo sapiens	153-157
27959445-5	2017	Delphinidin suppressed CoCl2- and EGF-induced hypoxia-response element (HRE) promoter activity, suggesting that the inhibitory effects of delphinidin on VEGF expression are caused by the suppression of the binding of HIF-1 to the HRE promoter.	delphinidin	138-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	217-222
27959445-6	2017	We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved.	delphinidin	19-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
27959445-6	2017	We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved.	delphinidin	19-30	AKT serine/threonine kinase 1	Homo sapiens	140-143
27959445-6	2017	We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved.	delphinidin	19-30	mechanistic target of rapamycin kinase	Homo sapiens	144-148
27959445-6	2017	We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved.	delphinidin	19-30	ribosomal protein S6 kinase B1	Homo sapiens	149-155
27959445-6	2017	We also found that delphinidin specifically decreased the CoCl2- and EGF-induced HIF-1alpha protein expression by blocking the ERK and PI3K/Akt/mTOR/p70S6K signaling pathways, whereas the p38-mediated pathways were not involved.	delphinidin	19-30	mitogen-activated protein kinase 14	Homo sapiens	188-191
27959445-8	2017	Therefore, our results indicate that delphinidin has a potentially new role in anti-angiogenic action by inhibiting HIF-1alpha and VEGF expression.	delphinidin	37-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
27959445-8	2017	Therefore, our results indicate that delphinidin has a potentially new role in anti-angiogenic action by inhibiting HIF-1alpha and VEGF expression.	delphinidin	37-48	vascular endothelial growth factor A	Homo sapiens	131-135
28000445-0	2017	Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression.	delphinidin	0-11	microRNA 23a	Mus musculus	52-59
28000445-3	2017	In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3.	delphinidin	65-76	tripartite motif-containing 63	Mus musculus	98-103
28000445-3	2017	In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3.	delphinidin	65-76	microRNA 23a	Mus musculus	105-112
28000445-3	2017	In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3.	delphinidin	65-76	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	Mus musculus	118-124
28000445-6	2017	Moreover, delphinidin suppressed MuRF1 (3.35 +- 0.13 vs 2.26 +- 0.3, P &lt; 0.01) expression and promoted miR-23a (0.58 +- 0.15 vs 2.25 +- 0.29, P &lt; 0.001) and NFATc3 (0.85 +- 0.17 vs 1.54 +- 0.13, P &lt; 0.001) expressions.	delphinidin	10-21	tripartite motif-containing 63	Mus musculus	33-38
28000445-6	2017	Moreover, delphinidin suppressed MuRF1 (3.35 +- 0.13 vs 2.26 +- 0.3, P &lt; 0.01) expression and promoted miR-23a (0.58 +- 0.15 vs 2.25 +- 0.29, P &lt; 0.001) and NFATc3 (0.85 +- 0.17 vs 1.54 +- 0.13, P &lt; 0.001) expressions.	delphinidin	10-21	microRNA 23a	Mus musculus	106-113
28000445-6	2017	Moreover, delphinidin suppressed MuRF1 (3.35 +- 0.13 vs 2.26 +- 0.3, P &lt; 0.01) expression and promoted miR-23a (0.58 +- 0.15 vs 2.25 +- 0.29, P &lt; 0.001) and NFATc3 (0.85 +- 0.17 vs 1.54 +- 0.13, P &lt; 0.001) expressions.	delphinidin	10-21	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	Mus musculus	163-169
28000445-7	2017	Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.	delphinidin	0-11	microRNA 23a	Mus musculus	65-72
28000445-7	2017	Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.	delphinidin	0-11	tripartite motif-containing 63	Mus musculus	100-105
27393705-0	2017	Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.	delphinidin	65-76	thymoma viral proto-oncogene 1	Mus musculus	24-27
27393705-0	2017	Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.	delphinidin	65-76	mechanistic target of rapamycin kinase	Mus musculus	32-36
27393705-10	2017	Innovation and Conclusion: Our observation that Del inhibits key kinases involved in psoriasis pathogenesis and alleviates IMQ-induced murine psoriasis-like disease suggests a novel PI3K/AKT/mTOR pathway modulator that could be developed to treat psoriasis.	delphinidin	48-51	thymoma viral proto-oncogene 1	Mus musculus	187-190
27393705-10	2017	Innovation and Conclusion: Our observation that Del inhibits key kinases involved in psoriasis pathogenesis and alleviates IMQ-induced murine psoriasis-like disease suggests a novel PI3K/AKT/mTOR pathway modulator that could be developed to treat psoriasis.	delphinidin	48-51	mechanistic target of rapamycin kinase	Mus musculus	191-195
29081896-4	2017	Both delphinidin and gallic acid generated oxygen-centred radicals at high (100 muM) concentrations in vitro.	delphinidin	5-16	latexin	Homo sapiens	80-83
29081896-5	2017	In a cultured human umbilical vein endothelial cell model of oxidative stress, the antioxidant protective effects of both delphinidin and gallic acid displayed a hormesic profile; 100 muM concentrations of both were cytotoxic, but relatively low concentrations (100 nM-1 muM) protected the cells and were associated with increased intracellular glutathione.	delphinidin	122-133	latexin	Homo sapiens	184-187
29081896-5	2017	In a cultured human umbilical vein endothelial cell model of oxidative stress, the antioxidant protective effects of both delphinidin and gallic acid displayed a hormesic profile; 100 muM concentrations of both were cytotoxic, but relatively low concentrations (100 nM-1 muM) protected the cells and were associated with increased intracellular glutathione.	delphinidin	122-133	latexin	Homo sapiens	271-274
27820958-1	2016	BACKGROUND: Previous research has suggested that supplementation with delphinidin-rich maqui berry extract Delphinol  significantly alters postprandial carbohydrate metabolism and acutely lowers both insulin and glucose at fasting conditions.	delphinidin	70-81	insulin	Homo sapiens	200-207
27462923-0	2016	Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells.	delphinidin	0-11	histone deacetylase 3	Homo sapiens	42-47
27462923-0	2016	Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells.	delphinidin	0-11	tumor protein p53	Homo sapiens	57-60
27462923-4	2016	We found that treatment of LNCaP cells (a p53 wild-type, human prostate cancer cell line) with delphinidin increased caspase-3, -7, and -8 activity, whereas it decreased histone deacetylase activity.	delphinidin	95-106	tumor protein p53	Homo sapiens	42-45
27462923-4	2016	We found that treatment of LNCaP cells (a p53 wild-type, human prostate cancer cell line) with delphinidin increased caspase-3, -7, and -8 activity, whereas it decreased histone deacetylase activity.	delphinidin	95-106	caspase 3	Homo sapiens	117-138
27462923-5	2016	Among class I HDACs, the activity of HDAC3 was specifically inhibited by delphinidin.	delphinidin	73-84	histone deacetylase 3	Homo sapiens	37-42
27462923-6	2016	Moreover, the induction of apoptosis by delphinidin was dependent on caspase-mediated cleavage of HDAC3, which results in the acetylation and stabilization of p53.	delphinidin	40-51	histone deacetylase 3	Homo sapiens	98-103
27462923-6	2016	Moreover, the induction of apoptosis by delphinidin was dependent on caspase-mediated cleavage of HDAC3, which results in the acetylation and stabilization of p53.	delphinidin	40-51	tumor protein p53	Homo sapiens	159-162
27462923-7	2016	We also observed that delphinidin potently upregulated pro-apoptotic genes that are positively regulated by p53, and downregulated various anti-apoptotic genes.	delphinidin	22-33	tumor protein p53	Homo sapiens	108-111
27462923-8	2016	Taken together, these results show that delphinidin induces p53-mediated apoptosis by suppressing HDAC activity and activating p53 acetylation in human prostate cancer LNCaP cells.	delphinidin	40-51	tumor protein p53	Homo sapiens	60-63
27462923-8	2016	Taken together, these results show that delphinidin induces p53-mediated apoptosis by suppressing HDAC activity and activating p53 acetylation in human prostate cancer LNCaP cells.	delphinidin	40-51	tumor protein p53	Homo sapiens	127-130
27180787-4	2016	Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b.	delphinidin	32-43	Cbl proto-oncogene B	Homo sapiens	145-150
27098861-7	2016	Cyanidin and delphinidin both showed inhibitory effects on the H2O2-induced increase in intracellular ROS formation and the activation of ERK1/2 and JNK.	delphinidin	13-24	mitogen-activated protein kinase 3	Homo sapiens	138-144
27098861-7	2016	Cyanidin and delphinidin both showed inhibitory effects on the H2O2-induced increase in intracellular ROS formation and the activation of ERK1/2 and JNK.	delphinidin	13-24	mitogen-activated protein kinase 8	Homo sapiens	149-152
27390740-0	2016	Suppression of beta-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin.	delphinidin	84-95	BTG anti-proliferation factor 2	Homo sapiens	71-74
27390740-5	2016	Treatment with delphinidin increased the phosphorylation of serine or threonine residues on beta-catenin and decreased the levels of cytoplasmic beta-catenin.	delphinidin	15-26	catenin beta 1	Homo sapiens	92-104
27390740-5	2016	Treatment with delphinidin increased the phosphorylation of serine or threonine residues on beta-catenin and decreased the levels of cytoplasmic beta-catenin.	delphinidin	15-26	catenin beta 1	Homo sapiens	145-157
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	catenin beta 1	Homo sapiens	76-88
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	catenin beta 1	Homo sapiens	111-123
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	cyclin D1	Homo sapiens	145-154
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	156-161
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	axin 2	Homo sapiens	163-169
27390740-7	2016	Delphinidin also induced the phosphorylation of glycogen synthase kinase 3beta and the expression of adenomatous polyposis coli and Axin proteins.	delphinidin	0-11	glycogen synthase kinase 3 beta	Homo sapiens	48-78
27390740-7	2016	Delphinidin also induced the phosphorylation of glycogen synthase kinase 3beta and the expression of adenomatous polyposis coli and Axin proteins.	delphinidin	0-11	axin 1	Homo sapiens	132-136
27390740-8	2016	Our results indicate that inhibition of cell growth by delphinidin is mediated, at least in part, through modulation of the beta-catenin signaling pathway.	delphinidin	55-66	catenin beta 1	Homo sapiens	124-136
27390740-9	2016	We suggest that delphinidin is a potent inhibitor of Wnt/beta-catenin signaling in prostate cancer cells.	delphinidin	16-27	catenin beta 1	Homo sapiens	57-69
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	mitogen-activated protein kinase 3	Mus musculus	54-60
27221932-0	2016	Virtual Screening Approaches in Identification of Bioactive Compounds Akin to Delphinidin as Potential HER2 Inhibitors for the Treatment of Breast Cancer.	delphinidin	78-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-107
27221932-2	2016	Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors.	delphinidin	101-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	211-215
27221932-4	2016	Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches.	delphinidin	42-53	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
26694325-0	2015	Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells.	delphinidin	0-11	vascular endothelial growth factor A	Mus musculus	47-51
26704080-0	2016	Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	112-115
26704080-0	2016	Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	120-126
26704080-0	2016	Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	127-131
26704080-6	2016	Phosphorylation of downstream targets of PI3K (AKT and p70S6K) and MAPKs (ERK1/2 and JNK) signaling was suppressed by treatment of ES2 cells with delphinidin.	delphinidin	146-157	AKT serine/threonine kinase 1	Homo sapiens	47-50
26704080-6	2016	Phosphorylation of downstream targets of PI3K (AKT and p70S6K) and MAPKs (ERK1/2 and JNK) signaling was suppressed by treatment of ES2 cells with delphinidin.	delphinidin	146-157	ribosomal protein S6 kinase B1	Homo sapiens	55-61
26704080-6	2016	Phosphorylation of downstream targets of PI3K (AKT and p70S6K) and MAPKs (ERK1/2 and JNK) signaling was suppressed by treatment of ES2 cells with delphinidin.	delphinidin	146-157	mitogen-activated protein kinase 3	Homo sapiens	74-80
26704080-6	2016	Phosphorylation of downstream targets of PI3K (AKT and p70S6K) and MAPKs (ERK1/2 and JNK) signaling was suppressed by treatment of ES2 cells with delphinidin.	delphinidin	146-157	mitogen-activated protein kinase 8	Homo sapiens	85-88
26704080-7	2016	In addition, pharmacological inhibitors of PI3K/AKT and ERK1/2 MAPK pathway improved the anti-proliferative action of delphinidin on ES2 cells.	delphinidin	118-129	AKT serine/threonine kinase 1	Homo sapiens	48-51
26704080-7	2016	In addition, pharmacological inhibitors of PI3K/AKT and ERK1/2 MAPK pathway improved the anti-proliferative action of delphinidin on ES2 cells.	delphinidin	118-129	mitogen-activated protein kinase 3	Homo sapiens	56-62
26704080-7	2016	In addition, pharmacological inhibitors of PI3K/AKT and ERK1/2 MAPK pathway improved the anti-proliferative action of delphinidin on ES2 cells.	delphinidin	118-129	mitogen-activated protein kinase 3	Homo sapiens	63-67
26704080-10	2016	Collectively, these results indicated that delphinidin plays a critical role as a new chemotherapeutic agent to prevent development and progression of ES2 cells in CCC via inactivation of PI3K/AKT and ERK1/2 MAPK signal transduction cascades.	delphinidin	43-54	AKT serine/threonine kinase 1	Homo sapiens	193-196
26704080-10	2016	Collectively, these results indicated that delphinidin plays a critical role as a new chemotherapeutic agent to prevent development and progression of ES2 cells in CCC via inactivation of PI3K/AKT and ERK1/2 MAPK signal transduction cascades.	delphinidin	43-54	mitogen-activated protein kinase 3	Homo sapiens	201-207
26704080-10	2016	Collectively, these results indicated that delphinidin plays a critical role as a new chemotherapeutic agent to prevent development and progression of ES2 cells in CCC via inactivation of PI3K/AKT and ERK1/2 MAPK signal transduction cascades.	delphinidin	43-54	mitogen-activated protein kinase 3	Homo sapiens	208-212
26816335-0	2016	Delphinidin, a major anthocyanin, inhibits 3T3-L1 pre-adipocyte differentiation through activation of Wnt/beta-catenin signaling.	delphinidin	0-11	Wnt family member 1	Homo sapiens	102-105
26816335-0	2016	Delphinidin, a major anthocyanin, inhibits 3T3-L1 pre-adipocyte differentiation through activation of Wnt/beta-catenin signaling.	delphinidin	0-11	catenin beta 1	Homo sapiens	106-118
26816335-8	2016	Our findings therefore suggest that Del can effectively inhibit adipogenesis followed by the stabilization of beta-catenin during early 3T3-L1 differentiation via inhibition of its destructive complexes and activation of Wnt signaling, and may thus be a promising candidate for the prevention of metabolic diseases, including obesity.	delphinidin	36-39	catenin beta 1	Homo sapiens	110-122
26816335-8	2016	Our findings therefore suggest that Del can effectively inhibit adipogenesis followed by the stabilization of beta-catenin during early 3T3-L1 differentiation via inhibition of its destructive complexes and activation of Wnt signaling, and may thus be a promising candidate for the prevention of metabolic diseases, including obesity.	delphinidin	36-39	Wnt family member 1	Homo sapiens	221-224
26694325-5	2015	In vitro, delphinidin was not able to inhibit VEGFR2-mediated B16-F10 melanoma cell proliferation but it specifically reduced basal and VEGFR2-mediated endothelial cell proliferation.	delphinidin	10-21	kinase insert domain protein receptor	Mus musculus	136-142
26694325-6	2015	The anti-proliferative effect of delphinidin was reversed either by the MEK1/2 MAP kinase inhibitor, U-0126, or the PI3K inhibitor, LY-294002.	delphinidin	33-44	mitogen-activated protein kinase kinase 1	Mus musculus	72-78
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	vascular endothelial growth factor A	Mus musculus	22-26
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	mitogen-activated protein kinase 14	Mus musculus	65-73
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	cAMP responsive element binding protein 1	Mus musculus	133-137
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	activating transcription factor 1	Mus musculus	142-146
26187071-0	2015	Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells.	delphinidin	135-146	microRNA 137	Homo sapiens	23-30
26187071-0	2015	Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells.	delphinidin	135-146	microRNA 137	Homo sapiens	82-89
26187071-7	2015	Our results also indicated the highest miR-137 expression after direct transfection of miR-137 mimics and DPN treatment.	delphinidin	106-109	microRNA 137	Homo sapiens	39-46
26187071-8	2015	Combination of miR-137 mimics transfection and DPN treatment caused the highest inhibition of cell invasion and prevented angiogenic network formation due to the least expression of angiogenic factor (VEGF) in human glioblastoma cells in co-culture with human microvascular endothelial cells.	delphinidin	47-50	vascular endothelial growth factor A	Homo sapiens	201-205
26187071-10	2015	Direct overexpression of miR-137 most effectively augmented efficacy of DPN to induce apoptosis with activation of extrinsic and intrinsic pathways.	delphinidin	72-75	microRNA 137	Homo sapiens	25-32
25954945-4	2015	The activation of caspase-8 and -9 was observed as early as 1-h post-exposure to delphinidin, followed by the activation of caspase-3 from 3-h post-exposure.	delphinidin	81-92	caspase 8	Homo sapiens	18-34
26442064-11	2015	Further, "Expasy ProtParam tool" results showed that Iris x hollandica DFR amino acids (Asn 9: Asp 23) are favorable for reducing DHQ and DHM thus accumulating delphinidin, while Gossypium hirsutum DFR has (Asn 13: Asp 21) hypothesized to consume DHK.	delphinidin	160-171	putative anthocyanidin reductase	Gossypium hirsutum	71-74
25533330-2	2015	We have shown that treatment of reconstituted human skin with delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, increased the expression and processing of caspase-14, which is involved in cornification.	delphinidin	62-73	caspase 14	Homo sapiens	180-190
25749779-0	2015	Inhibitory Effect of Delphinidin on Extracellular Matrix Production via the MAPK/NF-kappaB Pathway in Nasal Polyp-Derived Fibroblasts.	delphinidin	21-32	nuclear factor kappa B subunit 1	Homo sapiens	81-90
25749779-3	2015	The aims of this study were to examine the inhibitory effect of delphinidin on TGF-beta1-induced myofibroblast differentiation and ECM accumulation, and to determine the underlying mechanisms in nasal polyp-derived fibroblasts (NPDFs).	delphinidin	64-75	transforming growth factor beta 1	Homo sapiens	79-88
25749779-9	2015	In TGF-beta1-induced NPDFs, delphinidin inhibited the expression of alpha-SMA, fibronectin, and collagen.	delphinidin	28-39	transforming growth factor beta 1	Homo sapiens	3-12
25749779-9	2015	In TGF-beta1-induced NPDFs, delphinidin inhibited the expression of alpha-SMA, fibronectin, and collagen.	delphinidin	28-39	fibronectin 1	Homo sapiens	79-90
25749779-11	2015	Delphinidin suppressed the activation of MAPK and NF-kappaB induced by TGF-beta1 stimulation.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	50-59
25749779-11	2015	Delphinidin suppressed the activation of MAPK and NF-kappaB induced by TGF-beta1 stimulation.	delphinidin	0-11	transforming growth factor beta 1	Homo sapiens	71-80
25749779-12	2015	CONCLUSIONS: These results suggest that delphinidin may inhibit TGF-beta1-induced myofibroblast differentiation and ECM production through the MAPK/NF-kappaB signaling pathway in NPDFs.	delphinidin	40-51	transforming growth factor beta 1	Homo sapiens	64-73
25749779-12	2015	CONCLUSIONS: These results suggest that delphinidin may inhibit TGF-beta1-induced myofibroblast differentiation and ECM production through the MAPK/NF-kappaB signaling pathway in NPDFs.	delphinidin	40-51	nuclear factor kappa B subunit 1	Homo sapiens	148-157
25991668-0	2015	Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.	delphinidin	0-11	TNF superfamily member 10	Homo sapiens	48-53
25991668-0	2015	Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.	delphinidin	0-11	TNF receptor superfamily member 10b	Homo sapiens	85-88
25991668-0	2015	Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.	delphinidin	0-11	histone deacetylase 3	Homo sapiens	118-123
25991668-4	2015	Here we showed that delphinidin sensitized TRAIL-resistant human prostate cancer cells to undergo apoptosis.	delphinidin	20-31	TNF superfamily member 10	Homo sapiens	43-48
25991668-6	2015	TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3).	delphinidin	65-76	TNF superfamily member 10	Homo sapiens	0-5
25991668-6	2015	TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3).	delphinidin	65-76	TNF receptor superfamily member 10b	Homo sapiens	94-110
25991668-6	2015	TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3).	delphinidin	65-76	TNF receptor superfamily member 10b	Homo sapiens	112-115
25991668-6	2015	TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3).	delphinidin	65-76	histone deacetylase 3	Homo sapiens	144-165
25991668-6	2015	TRAIL-induced apoptosis in prostate cancer cells pretreated with delphinidin was dependent on death receptor 5 (DR5) and downstream cleavage of histone deacetylase 3 (HDAC3).	delphinidin	65-76	histone deacetylase 3	Homo sapiens	167-172
25991668-7	2015	In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage.	delphinidin	15-26	TNF superfamily member 10	Homo sapiens	63-68
25991668-7	2015	In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage.	delphinidin	15-26	TNF receptor superfamily member 10b	Homo sapiens	99-102
25991668-7	2015	In conclusion, delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis by inducing DR5, thus causing caspase-mediated HDAC3 cleavage.	delphinidin	15-26	histone deacetylase 3	Homo sapiens	134-139
25892567-6	2015	Furthermore, delphinidins increase endothelial nitric oxide synthase expression and decreases expression of vaso-constrictory endothelin-1.	delphinidin	13-25	nitric oxide synthase 3	Homo sapiens	35-68
25892567-6	2015	Furthermore, delphinidins increase endothelial nitric oxide synthase expression and decreases expression of vaso-constrictory endothelin-1.	delphinidin	13-25	endothelin 1	Homo sapiens	126-138
25892567-10	2015	Delphinidins dose-dependently inhibit NF-kappaB-, activator protein-1- as well as COX-2 expression in UV-exposed epidermis.	delphinidin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25533330-7	2015	Delphinidin treatment also increased the expression and processing of caspase-14, and expression of filaggrin, loricrin, keratin-1 and keratin-10.	delphinidin	0-11	caspase 14	Mus musculus	70-80
25533330-7	2015	Delphinidin treatment also increased the expression and processing of caspase-14, and expression of filaggrin, loricrin, keratin-1 and keratin-10.	delphinidin	0-11	loricrin	Mus musculus	111-119
25533330-7	2015	Delphinidin treatment also increased the expression and processing of caspase-14, and expression of filaggrin, loricrin, keratin-1 and keratin-10.	delphinidin	0-11	keratin 1	Mus musculus	121-130
25533330-7	2015	Delphinidin treatment also increased the expression and processing of caspase-14, and expression of filaggrin, loricrin, keratin-1 and keratin-10.	delphinidin	0-11	keratin 10	Mus musculus	135-145
25533330-9	2015	In addition, delphinidin treatment increased the expression of activator protein-1 transcription factor proteins (JunB, JunD, Fra1 and Fra2).	delphinidin	13-24	jun B proto-oncogene	Mus musculus	114-118
25533330-9	2015	In addition, delphinidin treatment increased the expression of activator protein-1 transcription factor proteins (JunB, JunD, Fra1 and Fra2).	delphinidin	13-24	jun D proto-oncogene	Mus musculus	120-124
25533330-9	2015	In addition, delphinidin treatment increased the expression of activator protein-1 transcription factor proteins (JunB, JunD, Fra1 and Fra2).	delphinidin	13-24	fos-like antigen 1	Mus musculus	126-130
25533330-9	2015	In addition, delphinidin treatment increased the expression of activator protein-1 transcription factor proteins (JunB, JunD, Fra1 and Fra2).	delphinidin	13-24	fos-like antigen 2	Mus musculus	135-139
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	mucin 8	Homo sapiens	33-37
25620035-6	2015	RESULTS: Our data show that treatment of PSE with delphinidin induced (1) cornification without affecting apoptosis and (2) the mRNA and protein expression of markers of differentiation (caspase-14, filaggrin, loricrin, involucrin).	delphinidin	50-61	caspase 14	Homo sapiens	187-197
25620035-6	2015	RESULTS: Our data show that treatment of PSE with delphinidin induced (1) cornification without affecting apoptosis and (2) the mRNA and protein expression of markers of differentiation (caspase-14, filaggrin, loricrin, involucrin).	delphinidin	50-61	loricrin cornified envelope precursor protein	Homo sapiens	210-218
25177436-6	2014	And the signaling pathway of delphinidin on LPS-induced MUC8 and MUC5B expression was investigated using the RT-PCR, and immunoblot analysis.	delphinidin	29-40	mucin 8	Homo sapiens	56-60
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	31-42	interleukin 6	Mus musculus	113-117
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	31-42	mast cell protease 1	Mus musculus	119-124
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	31-42	tumor necrosis factor	Mus musculus	130-139
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	19-21	interleukin 6	Mus musculus	113-117
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	19-21	mast cell protease 1	Mus musculus	119-124
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	19-21	tumor necrosis factor	Mus musculus	130-139
25728636-5	2015	In animal model, Dp3-Sam and Dp reduced the production of IL-6, MCP-1 and TNF-alpha and attenuated mouse paw edema induced by LPS.	delphinidin	17-19	interleukin 6	Mus musculus	58-62
25728636-5	2015	In animal model, Dp3-Sam and Dp reduced the production of IL-6, MCP-1 and TNF-alpha and attenuated mouse paw edema induced by LPS.	delphinidin	17-19	mast cell protease 1	Mus musculus	64-69
25728636-5	2015	In animal model, Dp3-Sam and Dp reduced the production of IL-6, MCP-1 and TNF-alpha and attenuated mouse paw edema induced by LPS.	delphinidin	17-19	tumor necrosis factor	Mus musculus	74-83
25177436-6	2014	And the signaling pathway of delphinidin on LPS-induced MUC8 and MUC5B expression was investigated using the RT-PCR, and immunoblot analysis.	delphinidin	29-40	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	65-70
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	toll like receptor 4	Homo sapiens	54-58
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	mucin 8	Homo sapiens	60-64
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	70-75
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	122-128
25177436-11	2014	Delphinidin (50 and 100 microM) inhibited LPS-induced TLR4, MUC8, and MUC5B expression and LPS-induced phosphorylation of ERK1/2 and p38 MAPK.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	133-136
25177436-12	2014	In the primary cultures of normal nasal epithelial cells, delphinidin (50 and 100 microM) significantly inhibited LPS-induced TLR4, MUC8, and MUC5B gene expression.	delphinidin	58-69	toll like receptor 4	Homo sapiens	126-130
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	42-47
25177436-12	2014	In the primary cultures of normal nasal epithelial cells, delphinidin (50 and 100 microM) significantly inhibited LPS-induced TLR4, MUC8, and MUC5B gene expression.	delphinidin	58-69	mucin 8	Homo sapiens	132-136
25177436-12	2014	In the primary cultures of normal nasal epithelial cells, delphinidin (50 and 100 microM) significantly inhibited LPS-induced TLR4, MUC8, and MUC5B gene expression.	delphinidin	58-69	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	142-147
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	toll like receptor 4	Homo sapiens	67-87
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mucin 8	Homo sapiens	74-78
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	83-88
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	97-103
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	toll like receptor 4	Homo sapiens	112-116
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mitogen-activated protein kinase 3	Homo sapiens	126-132
25177436-0	2014	Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	108-111
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mitogen-activated protein kinase 1	Homo sapiens	137-140
25177436-13	2014	CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.	delphinidin	39-50	mitogen-activated protein kinase 3	Homo sapiens	141-145
25177436-4	2014	Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of delphinidin in lipopolysaccharide (LPS)-induced MUC8 and MUC5B expression in human airway epithelial cells.	delphinidin	106-117	mucin 8	Homo sapiens	154-158
25177436-4	2014	Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of delphinidin in lipopolysaccharide (LPS)-induced MUC8 and MUC5B expression in human airway epithelial cells.	delphinidin	106-117	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	163-168
24792670-0	2014	Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells.	delphinidin	0-11	vascular endothelial growth factor A	Homo sapiens	21-25
24792670-0	2014	Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	63-66
24792670-7	2014	Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRalpha, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme activities.	delphinidin	0-11	nuclear respiratory factor 1	Homo sapiens	93-97
24792670-7	2014	Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRalpha, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme activities.	delphinidin	0-11	estrogen related receptor alpha	Homo sapiens	99-107
24792670-7	2014	Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRalpha, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme activities.	delphinidin	0-11	transcription factor A, mitochondrial	Homo sapiens	109-113
24792670-7	2014	Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRalpha, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme activities.	delphinidin	0-11	transcription factor B2, mitochondrial	Homo sapiens	115-120
24792670-7	2014	Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRalpha, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme activities.	delphinidin	0-11	DNA polymerase gamma, catalytic subunit	Homo sapiens	125-129
24792670-8	2014	In presence of delphinidin, VEGF failed to increase mitochondrial respiration, DNA content, complex IV activity and Akt activation in endothelial cells.	delphinidin	15-26	vascular endothelial growth factor A	Homo sapiens	28-32
24792670-9	2014	These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers.	delphinidin	128-139	vascular endothelial growth factor A	Homo sapiens	67-71
24792670-9	2014	These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers.	delphinidin	128-139	AKT serine/threonine kinase 1	Homo sapiens	113-116
24792670-9	2014	These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers.	delphinidin	236-247	vascular endothelial growth factor A	Homo sapiens	67-71
24792670-9	2014	These results suggest a possible association between inhibition of VEGF-induced mitochondrial biogenesis through Akt pathway by delphinidin and its anti-angiogenic effect, providing a novel mechanism sustaining the beneficial effect of delphinidin against pathologies associated with excessive angiogenesis such as cancers.	delphinidin	236-247	AKT serine/threonine kinase 1	Homo sapiens	113-116
24124611-7	2013	Furthermore, in athymic nude mice subcutaneously implanted with human NSCLC cells, delphinidin treatment caused a (i) significant inhibition of tumor growth, (ii) decrease in the expression of markers for cell proliferation (Ki67 and PCNA) and angiogenesis (CD31 and VEGF), and (iii) induction of apoptosis, when compared with control mice.	delphinidin	83-94	proliferating cell nuclear antigen	Homo sapiens	234-238
25000305-0	2014	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells.	delphinidin	0-11	matrix metallopeptidase 9	Homo sapiens	35-40
25000305-0	2014	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	68-77
25000305-4	2014	In this study, we investigated the antiproliferative and antiinvasive effects of delphinidin on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells using zymography, western blotting, reverse transcription-polymerase chain reaction, and Matrigel invasion assay.	delphinidin	81-92	matrix metallopeptidase 9	Homo sapiens	108-113
25000305-5	2014	Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways.	delphinidin	0-11	matrix metallopeptidase 9	Homo sapiens	49-54
25000305-5	2014	Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways.	delphinidin	0-11	matrix metallopeptidase 9	Homo sapiens	139-144
23943055-0	2014	Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells.	delphinidin	0-11	interleukin 2	Homo sapiens	39-43
23943055-6	2014	Delphinidin increased the mRNA expression and production of IL-2 in Jurkat cells and was inhibited by BTP2 and cyclosporine A.	delphinidin	0-11	interleukin 2	Homo sapiens	60-64
23943055-7	2014	Using peripheral blood lymphocytes, we demonstrated that delphinidin increased the production of IL-2 and IFN-gamma and was inhibited by BTP2.	delphinidin	57-68	interleukin 2	Homo sapiens	97-101
23943055-7	2014	Using peripheral blood lymphocytes, we demonstrated that delphinidin increased the production of IL-2 and IFN-gamma and was inhibited by BTP2.	delphinidin	57-68	interferon gamma	Homo sapiens	106-115
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	32-38
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-46
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-58
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-159
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	latexin	Homo sapiens	178-181
24387788-8	2014	Catalytic activities of CYP2C9, CYP2A6, CYP2B6, and CYP3A4 enzymes were inhibited by all anthocyanidins to different extents (e.g., delphinidin inhibits CYP3A4 by &gt;90% at 100 muM with IC50 = 32 muM).	delphinidin	132-143	latexin	Homo sapiens	197-200
23839497-5	2013	Further experiments in primary human keratinocytes preincubated with 1.2 mM calcium indicated that 1,25D and 10 muM delphinidin upregulate all five LCE3 genes (LCE3A-E).	delphinidin	116-127	latexin	Homo sapiens	112-115
23839497-6	2013	Competition binding assays employing radiolabeled 1,25D revealed that delphinidin binds VDR weakly (IC50   1 mM).	delphinidin	70-81	vitamin D receptor	Homo sapiens	88-91
23839497-7	2013	However, 20 muM delphinidin was capable of upregulating a luciferase reporter gene in a VDRE-dependent manner in a transfected keratinocyte cell line (KERTr).	delphinidin	16-27	latexin	Homo sapiens	12-15
23839497-8	2013	These results are consistent with a scenario in which delphinidin is metabolized to an active compound that then stimulates LCE3 transcription in a VDR/VDRE-dependent manner.	delphinidin	54-65	vitamin D receptor	Homo sapiens	148-151
24124611-0	2013	Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways.	delphinidin	0-11	epidermal growth factor receptor	Homo sapiens	110-114
24124611-0	2013	Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways.	delphinidin	0-11	kinase insert domain receptor	Homo sapiens	115-121
24124611-2	2013	In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2.	delphinidin	36-47	epidermal growth factor receptor	Homo sapiens	141-145
24124611-2	2013	In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2.	delphinidin	36-47	kinase insert domain receptor	Homo sapiens	150-156
24124611-2	2013	In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2.	delphinidin	36-47	epidermal growth factor receptor	Homo sapiens	151-155
24124611-2	2013	In the present study, we found that delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, is a potent inhibitor of both EGFR and VEGFR2 in NSCLC cells that overexpress EGFR/VEGFR2.	delphinidin	36-47	kinase insert domain receptor	Homo sapiens	194-200
24124611-4	2013	Delphinidin (5-60 microM) treatment of NSCLC cells inhibited the activation of PI3K, and phosphorylation of AKT and MAPKs.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	108-111
25000305-5	2014	Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	205-213
25000305-5	2014	Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	215-224
25000305-7	2014	These results suggest that delphinidin is a potential antimetastatic agent that suppresses PMA-induced cancer cell invasion through the specific inhibition of NF-kappaB-dependent MMP-9 gene expression.	delphinidin	27-38	nuclear factor kappa B subunit 1	Homo sapiens	159-168
25000305-7	2014	These results suggest that delphinidin is a potential antimetastatic agent that suppresses PMA-induced cancer cell invasion through the specific inhibition of NF-kappaB-dependent MMP-9 gene expression.	delphinidin	27-38	matrix metallopeptidase 9	Homo sapiens	179-184
24824988-6	2014	Oral administration of delphinidin significantly prevented bone loss in both RANKL-induced osteoporosis model mice and OVX model mice.	delphinidin	23-34	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	77-82
24824988-7	2014	We further provide evidence that delphinidin suppressed the activity of NF-kappaB, c-fos, and Nfatc1, master transcriptional factors for osteoclastogenesis.	delphinidin	33-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
24824988-7	2014	We further provide evidence that delphinidin suppressed the activity of NF-kappaB, c-fos, and Nfatc1, master transcriptional factors for osteoclastogenesis.	delphinidin	33-44	FBJ osteosarcoma oncogene	Mus musculus	83-88
24824988-7	2014	We further provide evidence that delphinidin suppressed the activity of NF-kappaB, c-fos, and Nfatc1, master transcriptional factors for osteoclastogenesis.	delphinidin	33-44	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	94-100
24124611-7	2013	Furthermore, in athymic nude mice subcutaneously implanted with human NSCLC cells, delphinidin treatment caused a (i) significant inhibition of tumor growth, (ii) decrease in the expression of markers for cell proliferation (Ki67 and PCNA) and angiogenesis (CD31 and VEGF), and (iii) induction of apoptosis, when compared with control mice.	delphinidin	83-94	platelet and endothelial cell adhesion molecule 1	Homo sapiens	258-262
24124611-7	2013	Furthermore, in athymic nude mice subcutaneously implanted with human NSCLC cells, delphinidin treatment caused a (i) significant inhibition of tumor growth, (ii) decrease in the expression of markers for cell proliferation (Ki67 and PCNA) and angiogenesis (CD31 and VEGF), and (iii) induction of apoptosis, when compared with control mice.	delphinidin	83-94	vascular endothelial growth factor A	Homo sapiens	267-271
24124611-8	2013	Based on these observations, we suggest that delphinidin, alone or as an adjuvant to current therapies, could be used for the management of NSCLC, especially those that overexpress EGFR and VEGFR2.	delphinidin	45-56	epidermal growth factor receptor	Homo sapiens	181-185
24124611-8	2013	Based on these observations, we suggest that delphinidin, alone or as an adjuvant to current therapies, could be used for the management of NSCLC, especially those that overexpress EGFR and VEGFR2.	delphinidin	45-56	kinase insert domain receptor	Homo sapiens	190-196
23392593-7	2013	RESULTS: Delphinidin inhibited IL-1beta-induced expression of COX-2 and production of PGE2 in human chondrocytes.	delphinidin	9-20	interleukin 1 beta	Homo sapiens	31-39
23320385-3	2013	The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT).	delphinidin	80-91	beta-1,3-glucuronyltransferase 2	Homo sapiens	254-282
23320385-3	2013	The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT).	delphinidin	80-91	beta-1,3-glucuronyltransferase 2	Homo sapiens	284-287
23320385-10	2013	Delphinidin acted as significant non-competitive inhibitor of human CBR with IC50 = 16 microM (at substrate concentration 500 microM).	delphinidin	0-11	carbonyl reductase 1	Homo sapiens	68-71
23584725-0	2013	Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kappaB, and Akt inhibition.	delphinidin	0-11	mitogen-activated protein kinase 8	Mus musculus	155-158
23584725-0	2013	Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kappaB, and Akt inhibition.	delphinidin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
23584725-0	2013	Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kappaB, and Akt inhibition.	delphinidin	0-11	thymoma viral proto-oncogene 1	Mus musculus	178-181
23584725-5	2013	Hypoxia increased phosphorylation of JNK and NF-kappaB were blocked by pretreatment of delphinidin as well as NAC.	delphinidin	87-98	mitogen-activated protein kinase 8	Mus musculus	37-40
23584725-5	2013	Hypoxia increased phosphorylation of JNK and NF-kappaB were blocked by pretreatment of delphinidin as well as NAC.	delphinidin	87-98	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	45-54
23584725-6	2013	Hypoxia decreased phosphorylation of Akt(thr308) and (ser473); these decreases were reversed by pretreatment with delphinidin or NAC.	delphinidin	114-125	thymoma viral proto-oncogene 1	Mus musculus	37-40
23584725-8	2013	Delphinidin attenuated the hypoxia-induced increase in Bax, cleaved caspase-9, cleaved caspase-3, and decrease in Bcl-2, which were diminished by pretreatment of Akt inhibitor.	delphinidin	0-11	BCL2-associated X protein	Mus musculus	55-58
23584725-8	2013	Delphinidin attenuated the hypoxia-induced increase in Bax, cleaved caspase-9, cleaved caspase-3, and decrease in Bcl-2, which were diminished by pretreatment of Akt inhibitor.	delphinidin	0-11	caspase 9	Mus musculus	68-77
23584725-8	2013	Delphinidin attenuated the hypoxia-induced increase in Bax, cleaved caspase-9, cleaved caspase-3, and decrease in Bcl-2, which were diminished by pretreatment of Akt inhibitor.	delphinidin	0-11	B cell leukemia/lymphoma 2	Mus musculus	114-119
23584725-8	2013	Delphinidin attenuated the hypoxia-induced increase in Bax, cleaved caspase-9, cleaved caspase-3, and decrease in Bcl-2, which were diminished by pretreatment of Akt inhibitor.	delphinidin	0-11	thymoma viral proto-oncogene 1	Mus musculus	162-165
23584725-11	2013	Hypoxia induced cleavage of procaspase-9 and procaspase-3 which were blocked by delphinidin or SP600125, but Akt inhibitor abolished the protection effect of delphinidin.	delphinidin	158-169	thymoma viral proto-oncogene 1	Mus musculus	109-112
23584725-12	2013	Moreover, inhibition of JNK and NF-kappaB abolished hypoxia-induced ES cell apoptosis and inhibition of Akt attenuated delphinidin-induced blockage of apoptosis.	delphinidin	119-130	thymoma viral proto-oncogene 1	Mus musculus	104-107
23584725-13	2013	The results indicate that delphinidin can prevent hypoxia-induced apoptosis of ES cells through the inhibition of JNK and NF-kappaB phosphorylation, and restoration of Akt phosphorylation.	delphinidin	26-37	mitogen-activated protein kinase 8	Mus musculus	114-117
23584725-13	2013	The results indicate that delphinidin can prevent hypoxia-induced apoptosis of ES cells through the inhibition of JNK and NF-kappaB phosphorylation, and restoration of Akt phosphorylation.	delphinidin	26-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-131
23584725-13	2013	The results indicate that delphinidin can prevent hypoxia-induced apoptosis of ES cells through the inhibition of JNK and NF-kappaB phosphorylation, and restoration of Akt phosphorylation.	delphinidin	26-37	thymoma viral proto-oncogene 1	Mus musculus	168-171
23711068-7	2013	Collectively, our results suggest that delphinidin targets NOX, resulting in the suppression of UVB-induced MMP-1 expression in human dermal fibroblasts.	delphinidin	39-50	matrix metallopeptidase 1	Homo sapiens	108-113
23392593-0	2013	Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.	delphinidin	0-11	interleukin 1 beta	Homo sapiens	21-29
23392593-0	2013	Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	52-61
23392593-0	2013	Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.	delphinidin	0-11	interleukin 1 receptor associated kinase 1	Homo sapiens	99-105
23392593-3	2013	In the present study we determined whether delphinidin would inhibit the IL-1beta-induced activation of NF-kappaB in human chondrocytes and determined the mechanism of its action.	delphinidin	43-54	interleukin 1 beta	Homo sapiens	73-81
23392593-3	2013	In the present study we determined whether delphinidin would inhibit the IL-1beta-induced activation of NF-kappaB in human chondrocytes and determined the mechanism of its action.	delphinidin	43-54	nuclear factor kappa B subunit 1	Homo sapiens	104-113
23711068-0	2013	NADPH oxidase is a novel target of delphinidin for the inhibition of UVB-induced MMP-1 expression in human dermal fibroblasts.	delphinidin	35-46	matrix metallopeptidase 1	Homo sapiens	81-86
23711068-2	2013	Delphinidin treatment significantly inhibited UVB-induced MMP-1 expression in primary cultured human dermal fibroblasts (HDF), an effect associated with the suppression of MKK4-JNK1/2, MKK3/6-p38 and MEK-ERK1/2 phosphorylation.	delphinidin	0-11	matrix metallopeptidase 1	Homo sapiens	58-63
23711068-2	2013	Delphinidin treatment significantly inhibited UVB-induced MMP-1 expression in primary cultured human dermal fibroblasts (HDF), an effect associated with the suppression of MKK4-JNK1/2, MKK3/6-p38 and MEK-ERK1/2 phosphorylation.	delphinidin	0-11	mitogen-activated protein kinase kinase 4	Homo sapiens	172-176
23711068-2	2013	Delphinidin treatment significantly inhibited UVB-induced MMP-1 expression in primary cultured human dermal fibroblasts (HDF), an effect associated with the suppression of MKK4-JNK1/2, MKK3/6-p38 and MEK-ERK1/2 phosphorylation.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	177-183
23711068-2	2013	Delphinidin treatment significantly inhibited UVB-induced MMP-1 expression in primary cultured human dermal fibroblasts (HDF), an effect associated with the suppression of MKK4-JNK1/2, MKK3/6-p38 and MEK-ERK1/2 phosphorylation.	delphinidin	0-11	mitogen-activated protein kinase kinase 7	Homo sapiens	200-203
23711068-2	2013	Delphinidin treatment significantly inhibited UVB-induced MMP-1 expression in primary cultured human dermal fibroblasts (HDF), an effect associated with the suppression of MKK4-JNK1/2, MKK3/6-p38 and MEK-ERK1/2 phosphorylation.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	204-210
23711068-6	2013	Pull down assays demonstrated that delphinidin binds directly to P47(phox) in vitro.	delphinidin	35-46	pleckstrin	Homo sapiens	65-68
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	interleukin 1 beta	Homo sapiens	27-35
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	126-139
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	155-162
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	NFKB inhibitor alpha	Homo sapiens	179-191
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	237-246
23392593-8	2013	Delphinidin also inhibited IL-1beta-mediated phosphorylation of IL-1 receptor-associated kinase-1(Ser376), phosphorylation of IKKalpha/beta, expression of IKKbeta, degradation of IkappaBalpha, and activation and nuclear translocation of NF-kappaB/p65.	delphinidin	0-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	247-250
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	19-46
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	68-93
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	95-98
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	142-145
23392593-9	2013	Phosphorylation of TGF-beta-activated kinase 1 was not observed but NF-kappaB-inducing kinase (NIK) was phosphorylated and phosphorylation of NIK was blocked by delphinidin in IL-1beta-treated human chondrocytes.	delphinidin	161-172	interleukin 1 beta	Homo sapiens	176-184
23392593-10	2013	CONCLUSION: These data identify delphinidin as a novel inhibitor of IL-1beta-induced production of cartilage-degrading molecule PGE2 via inhibition of COX-2 expression and provide new insight into the mechanism of its action.	delphinidin	32-43	interleukin 1 beta	Homo sapiens	68-76
23392593-11	2013	Our results also identify inhibition of IRAK1(Ser376) phosphorylation by delphinidin in IL-1beta-induced activation of NF-kappaB in human chondrocytes.	delphinidin	73-84	interleukin 1 receptor associated kinase 1	Homo sapiens	40-45
23392593-11	2013	Our results also identify inhibition of IRAK1(Ser376) phosphorylation by delphinidin in IL-1beta-induced activation of NF-kappaB in human chondrocytes.	delphinidin	73-84	interleukin 1 beta	Homo sapiens	88-96
23392593-11	2013	Our results also identify inhibition of IRAK1(Ser376) phosphorylation by delphinidin in IL-1beta-induced activation of NF-kappaB in human chondrocytes.	delphinidin	73-84	nuclear factor kappa B subunit 1	Homo sapiens	119-128
23129091-6	2012	Delphinidin treatment resulted in the accumulation of the lipidated form of Map1lc3b protein in an Atg5-dependent manner in mouse embryonic fibroblasts.	delphinidin	0-11	microtubule-associated protein 1 light chain 3 beta	Mus musculus	76-84
23419638-1	2013	We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.	delphinidin	53-64	aryl hydrocarbon receptor	Homo sapiens	118-143
23419638-6	2013	Enzyme kinetic analyses using human liver microsomes revealed inhibition of CYP1A1 activity by delphinidin (IC50 78 muM) and pelargonidin (IC50 33 muM).	delphinidin	95-106	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
23419638-6	2013	Enzyme kinetic analyses using human liver microsomes revealed inhibition of CYP1A1 activity by delphinidin (IC50 78 muM) and pelargonidin (IC50 33 muM).	delphinidin	95-106	latexin	Homo sapiens	116-119
23419638-7	2013	Overall, although most anthocyanidins had no effects on AhR-CYP1A1 signaling, pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity.	delphinidin	180-191	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	204-210
23129091-6	2012	Delphinidin treatment resulted in the accumulation of the lipidated form of Map1lc3b protein in an Atg5-dependent manner in mouse embryonic fibroblasts.	delphinidin	0-11	autophagy related 5	Mus musculus	99-103
22872589-0	2012	Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin.	delphinidin	46-57	renin	Homo sapiens	16-21
22872589-3	2012	However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood.	delphinidin	57-68	renin	Homo sapiens	108-113
21695376-3	2011	The results showed that the pre-treatment with delphinidin (50, 100, or 200 muM) dose-dependently decreased the ox-LDL-induced up-regulation of the expression of ICAM-1 and P-selectin, and the enhanced adhesion and transmigration of monocytes.	delphinidin	47-58	intercellular adhesion molecule 1	Homo sapiens	162-168
22872589-4	2012	In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production.	delphinidin	35-46	renin	Homo sapiens	84-89
22872589-5	2012	Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production.	delphinidin	35-46	renin	Homo sapiens	81-86
21695376-3	2011	The results showed that the pre-treatment with delphinidin (50, 100, or 200 muM) dose-dependently decreased the ox-LDL-induced up-regulation of the expression of ICAM-1 and P-selectin, and the enhanced adhesion and transmigration of monocytes.	delphinidin	47-58	selectin P	Homo sapiens	173-183
21695376-5	2011	The results showed that delphinidin attenuated ox-LDL-induced generation of ROS, p38MAPK protein expression, NF-kappaB transcription activity and protein expression, IkappaB-alpha degradation, NADPH oxidase subunit (Nox2 and p22phox) protein and mRNA expression in endothelial cells in a dose-dependent manner.	delphinidin	24-35	NFKB inhibitor alpha	Homo sapiens	166-179
21695376-5	2011	The results showed that delphinidin attenuated ox-LDL-induced generation of ROS, p38MAPK protein expression, NF-kappaB transcription activity and protein expression, IkappaB-alpha degradation, NADPH oxidase subunit (Nox2 and p22phox) protein and mRNA expression in endothelial cells in a dose-dependent manner.	delphinidin	24-35	cytochrome b-245 beta chain	Homo sapiens	216-220
21695376-5	2011	The results showed that delphinidin attenuated ox-LDL-induced generation of ROS, p38MAPK protein expression, NF-kappaB transcription activity and protein expression, IkappaB-alpha degradation, NADPH oxidase subunit (Nox2 and p22phox) protein and mRNA expression in endothelial cells in a dose-dependent manner.	delphinidin	24-35	cytochrome b-245 alpha chain	Homo sapiens	225-232
21695376-6	2011	These results suggest that delphinidin attenuates ox-LDL induced expression of adhesion molecules (P-selectin and ICAM-1) and the adhesion of monocytes to endothelial cells by inhibiting ROS/p38MAPK/NF-kappaB pathway.	delphinidin	27-38	selectin P	Homo sapiens	99-109
21695376-6	2011	These results suggest that delphinidin attenuates ox-LDL induced expression of adhesion molecules (P-selectin and ICAM-1) and the adhesion of monocytes to endothelial cells by inhibiting ROS/p38MAPK/NF-kappaB pathway.	delphinidin	27-38	intercellular adhesion molecule 1	Homo sapiens	114-120
20801663-0	2010	Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.	delphinidin	0-11	glyoxalase I	Homo sapiens	69-81
21683061-0	2011	Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-kappaB acetylation in fibroblast-like synoviocyte MH7A cells.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	116-125
21683061-4	2011	DP specifically inhibited the HAT activities of p300/CBP.	delphinidin	0-2	E1A binding protein p300	Homo sapiens	48-52
21683061-4	2011	DP specifically inhibited the HAT activities of p300/CBP.	delphinidin	0-2	CREB binding protein	Homo sapiens	53-56
21683061-6	2011	DP-induced hypoacetylation was accompanied by cytosolic accumulation of p65 and nuclear localization of IKBalpha.	delphinidin	0-2	RELA proto-oncogene, NF-kB subunit	Homo sapiens	72-75
21683061-7	2011	Accordingly, DP treatment inhibited TNFalpha-stimulated increases in NF-kappaB function and expression of NF-kappaB target genes in these cells.	delphinidin	13-15	tumor necrosis factor	Homo sapiens	36-44
21683061-7	2011	Accordingly, DP treatment inhibited TNFalpha-stimulated increases in NF-kappaB function and expression of NF-kappaB target genes in these cells.	delphinidin	13-15	nuclear factor kappa B subunit 1	Homo sapiens	69-78
21683061-7	2011	Accordingly, DP treatment inhibited TNFalpha-stimulated increases in NF-kappaB function and expression of NF-kappaB target genes in these cells.	delphinidin	13-15	nuclear factor kappa B subunit 1	Homo sapiens	106-115
21683061-9	2011	Together, these results show that the HATi activity of DP counters anti-inflammatory signaling by blocking p65 acetylation and that this compound may be useful in preventing inflammatory arthritis.	delphinidin	55-57	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-110
21792311-0	2011	Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines.	delphinidin	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
21792311-0	2011	Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines.	delphinidin	0-11	mitogen-activated protein kinase 3	Homo sapiens	30-36
21792311-0	2011	Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines.	delphinidin	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	72-76
21792311-5	2011	In comparison to vehicle control, delphinidin inhibited proliferation (P &lt; 0.05), blocked anchorage-independent growth (P &lt; 0.05), and induced apoptosis (P &lt; 0.05) of ER-positive, triple negative, and HER2-overexpressing breast cancer cell lines with limited toxicity to non-transformed breast epithelial cells.	delphinidin	34-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	210-214
21792311-6	2011	MAPK signaling was partially reduced in triple negative cells and ER-negative chemically transformed MCF10A cells after treatment with delphinidin.	delphinidin	135-146	mitogen-activated protein kinase 3	Homo sapiens	0-4
21792311-7	2011	In addition, delphinidin induced a significant level of apoptosis in HER2-overexpressing cells in association with reduced HER2 and MAPK signaling.	delphinidin	13-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-73
21792311-7	2011	In addition, delphinidin induced a significant level of apoptosis in HER2-overexpressing cells in association with reduced HER2 and MAPK signaling.	delphinidin	13-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-127
21792311-7	2011	In addition, delphinidin induced a significant level of apoptosis in HER2-overexpressing cells in association with reduced HER2 and MAPK signaling.	delphinidin	13-24	mitogen-activated protein kinase 3	Homo sapiens	132-136
21792311-8	2011	Since delphinidin is often consumed as a complementary cancer medicine, the effect of delphinidin on response to specific HER2-targeted breast cancer therapies was examined by proliferation assay.	delphinidin	86-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-126
21792311-10	2011	In summary, the data presented here suggest that single agent delphinidin exhibits growth inhibitory activity in breast cancer cells of various molecular subtypes, but raise concerns regarding potential drug antagonism when used in combination with existing targeted therapies in HER2-overexpressing breast cancer.	delphinidin	62-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	280-284
20846146-0	2010	The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae.	delphinidin	49-60	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	95-99
20846146-0	2010	The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae.	delphinidin	49-60	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	104-108
20846146-7	2010	Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin.	delphinidin	28-39	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	153-157
20846146-7	2010	Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin.	delphinidin	28-39	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	160-164
20846146-7	2010	Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin.	delphinidin	28-39	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	221-225
20846146-7	2010	Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin.	delphinidin	28-39	stress-responsive transcriptional activator MSN4	Saccharomyces cerevisiae S288C	230-234
20801663-4	2010	Among them, delphinidin was found to have the most potent inhibitory effect on human GLO I.	delphinidin	12-23	glyoxalase I	Homo sapiens	85-90
20801663-6	2010	Furthermore, we determined a pharmacophore for delphinidin binding to the human GLO I by computational simulation analyses of the binding modes of delphinidin, cyanidin and pelargonidin to the enzyme hot spot.	delphinidin	47-58	glyoxalase I	Homo sapiens	80-85
20801663-6	2010	Furthermore, we determined a pharmacophore for delphinidin binding to the human GLO I by computational simulation analyses of the binding modes of delphinidin, cyanidin and pelargonidin to the enzyme hot spot.	delphinidin	147-158	glyoxalase I	Homo sapiens	80-85
20801663-7	2010	These results suggest that delphinidin could be a useful lead compound for the development of novel GLO I inhibitory anticancer drugs.	delphinidin	27-38	glyoxalase I	Homo sapiens	100-105
20041802-3	2009	Competitive radioligand binding assays identified cyanidin (K(i) = 16.2 microM) and delphinidin (K(i) = 21.3 microM) as ligands with moderate affinity to human CB1.	delphinidin	84-95	cannabinoid receptor 1	Homo sapiens	160-163
20371262-8	2010	Delphinidin has successfully attenuated oxidative stress, increased matrix metalloproteinase-9 and metallothionein I/II expression and restored hepatic architecture.	delphinidin	0-11	matrix metallopeptidase 9	Mus musculus	68-94
20371262-8	2010	Delphinidin has successfully attenuated oxidative stress, increased matrix metalloproteinase-9 and metallothionein I/II expression and restored hepatic architecture.	delphinidin	0-11	metallothionein 1	Mus musculus	99-116
20371262-9	2010	Furthermore, the overexpression of tumor necrosis factor-alpha and transforming growth factor-beta1 has been withdrawn by delphinidin.	delphinidin	122-133	tumor necrosis factor	Mus musculus	35-99
20025272-4	2010	Delphinidin induced significant lipidation of LC3, an indication of macroautophagy, which was also suppressed by 3-methyladenine.	delphinidin	0-11	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	46-49
19818742-7	2010	Finally, delphinidin can efficiently prevent the down-regulation of Bcl-2 protein and up-regulation of Bax protein.	delphinidin	9-20	BCL2 apoptosis regulator	Homo sapiens	68-73
19818742-7	2010	Finally, delphinidin can efficiently prevent the down-regulation of Bcl-2 protein and up-regulation of Bax protein.	delphinidin	9-20	BCL2 associated X, apoptosis regulator	Homo sapiens	103-106
21103079-1	2010	Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells.	delphinidin	80-91	interferon alpha inducible protein 27	Homo sapiens	124-127
21103079-1	2010	Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells.	delphinidin	80-91	cyclin dependent kinase inhibitor 1B	Homo sapiens	128-132
21103079-1	2010	Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells.	delphinidin	80-91	interferon alpha inducible protein 27	Homo sapiens	150-153
21103079-8	2010	While the level of p27 was responsive to hydrogen peroxide and delphinidin, it remained unchanged in BPRc1, suggesting that the regulation of p27 requires functional HIF-1beta.	delphinidin	63-74	interferon alpha inducible protein 27	Homo sapiens	19-22
21103079-9	2010	We also found that hydrogen peroxide and delphinidin affected PI3K/Akt/mTOR signaling pathway which is one of upstream regulators of HIFs.	delphinidin	41-52	AKT serine/threonine kinase 1	Homo sapiens	67-70
21103079-9	2010	We also found that hydrogen peroxide and delphinidin affected PI3K/Akt/mTOR signaling pathway which is one of upstream regulators of HIFs.	delphinidin	41-52	mechanistic target of rapamycin kinase	Homo sapiens	71-75
21103079-10	2010	In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway.	delphinidin	49-60	interferon alpha inducible protein 27	Homo sapiens	101-104
21103079-10	2010	In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway.	delphinidin	49-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-129
21103079-10	2010	In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway.	delphinidin	49-60	AKT serine/threonine kinase 1	Homo sapiens	210-213
21103079-10	2010	In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway.	delphinidin	49-60	mechanistic target of rapamycin kinase	Homo sapiens	214-218
20202836-2	2010	Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of Fc epsilonRI.	delphinidin	33-44	Fc epsilon receptor Ia	Homo sapiens	155-167
20049322-5	2010	Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells.	delphinidin	19-30	palmitoyl-protein thioesterase 1	Mus musculus	75-78
20049322-5	2010	Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells.	delphinidin	19-30	estrogen receptor 1 (alpha)	Mus musculus	140-147
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	delphinidin	92-103	estrogen receptor 1 (alpha)	Mus musculus	34-41
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	delphinidin	92-103	Rous sarcoma oncogene	Mus musculus	128-131
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	delphinidin	92-103	mitogen-activated protein kinase 3	Mus musculus	133-140
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	delphinidin	92-103	nitric oxide synthase 3, endothelial cell	Mus musculus	142-146
20049322-6	2010	Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production.	delphinidin	92-103	caveolin 1, caveolae protein	Mus musculus	148-158
20049322-7	2010	Furthermore, direct interaction between delphinidin and ERalpha activator site is demonstrated using both binding assay and docking.	delphinidin	40-51	estrogen receptor 1 (alpha)	Mus musculus	56-63
20049322-9	2010	CONCLUSIONS/SIGNIFICANCE: This study provides evidence that red wine polyphenols, especially delphinidin, exert their endothelial benefits via ERalpha activation.	delphinidin	93-104	estrogen receptor 1 (alpha)	Mus musculus	143-150
20041802-4	2009	For CB2, similar affinities were achieved by cyanidin (K(i) = 33.5 microM), delphinidin (K(i) = 34.3 microM), and peonidin (K(i) = 46.4 microM).	delphinidin	76-87	cannabinoid receptor 2	Homo sapiens	4-7
19653223-1	2009	Delphinidin has been reported to inhibit EGFR signalling.	delphinidin	0-11	epidermal growth factor receptor	Homo sapiens	41-45
19776176-0	2009	Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase.	delphinidin	0-11	mitogen-activated protein kinase kinase 4	Mus musculus	96-102
19776176-3	2009	Here, we investigated the effects of delphinidin, an abundant dietary anthocyanin, on UVB-induced COX-2 upregulation and the underlying molecular mechanism.	delphinidin	37-48	prostaglandin-endoperoxide synthase 2	Mus musculus	98-103
19776176-4	2009	We found that delphinidin suppressed UVB-induced COX-2 expression in JB6 P+ mouse epidermal cells.	delphinidin	14-25	prostaglandin-endoperoxide synthase 2	Mus musculus	49-54
19776176-5	2009	COX-2 promoter activity and PGE(2) production were also suppressed by delphinidin treatment within non-cytotoxic concentrations.	delphinidin	70-81	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
19776176-6	2009	Activator protein-1 and nuclear factor-kappaB, crucial transcription factors involved in COX-2 expression, were activated by UVB and delphinidin abolished this activation.	delphinidin	133-144	jun proto-oncogene	Mus musculus	0-45
19776176-6	2009	Activator protein-1 and nuclear factor-kappaB, crucial transcription factors involved in COX-2 expression, were activated by UVB and delphinidin abolished this activation.	delphinidin	133-144	prostaglandin-endoperoxide synthase 2	Mus musculus	89-94
19776176-7	2009	UVB-induced phosphorylation of c-Jun N-terminal kinase, p38 kinase and Akt was inhibited by delphinidin.	delphinidin	92-103	mitogen-activated protein kinase 14	Mus musculus	56-59
19776176-7	2009	UVB-induced phosphorylation of c-Jun N-terminal kinase, p38 kinase and Akt was inhibited by delphinidin.	delphinidin	92-103	thymoma viral proto-oncogene 1	Mus musculus	71-74
19776176-8	2009	The activities of mitogen-activated protein kinase kinase (MAPKK) 4 and phosphatidylinositol-3 kinase (PI-3K) were inhibited markedly by delphinidin.	delphinidin	137-148	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	72-101
19776176-9	2009	A pull-down assay using delphinidin-Sepharose beads revealed that delphinidin binds directly with MAPKK4 or PI-3K in a manner that was competitive with adenosine triphosphate.	delphinidin	24-35	mitogen-activated protein kinase kinase 4	Mus musculus	98-104
19776176-9	2009	A pull-down assay using delphinidin-Sepharose beads revealed that delphinidin binds directly with MAPKK4 or PI-3K in a manner that was competitive with adenosine triphosphate.	delphinidin	66-77	mitogen-activated protein kinase kinase 4	Mus musculus	98-104
19776176-10	2009	Moreover, in vivo investigations using mouse skin revealed that the upregulation of COX-2 expression, MAPKK4 activity and PI-3K activity induced by UVB was abolished with delphinidin treatment.	delphinidin	171-182	prostaglandin-endoperoxide synthase 2	Mus musculus	84-89
19776176-10	2009	Moreover, in vivo investigations using mouse skin revealed that the upregulation of COX-2 expression, MAPKK4 activity and PI-3K activity induced by UVB was abolished with delphinidin treatment.	delphinidin	171-182	mitogen-activated protein kinase kinase 4	Mus musculus	102-108
19776176-11	2009	Collectively, our results demonstrated that delphinidin targets MAPKK4 and PI-3K directly to suppress COX-2 overexpression, suggesting a potential protective role for delphinidin against UVB-mediated skin carcinogenesis.	delphinidin	44-55	mitogen-activated protein kinase kinase 4	Mus musculus	64-70
19776176-11	2009	Collectively, our results demonstrated that delphinidin targets MAPKK4 and PI-3K directly to suppress COX-2 overexpression, suggesting a potential protective role for delphinidin against UVB-mediated skin carcinogenesis.	delphinidin	44-55	prostaglandin-endoperoxide synthase 2	Mus musculus	102-107
19653223-0	2009	Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.	delphinidin	0-11	epidermal growth factor receptor	Homo sapiens	74-78
19653223-0	2009	Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.	delphinidin	0-11	kinase insert domain receptor	Homo sapiens	83-88
19653223-2	2009	To determine whether other receptor tyrosine kinases (RTKs) are also influenced by delphinidin, we examined its ability to inhibit the kinase activity of EGFR, ErbB2, VEGFR-2, VEGFR-3 and IGF1R in a cell-free test system.	delphinidin	83-94	epidermal growth factor receptor	Homo sapiens	154-158
19653223-2	2009	To determine whether other receptor tyrosine kinases (RTKs) are also influenced by delphinidin, we examined its ability to inhibit the kinase activity of EGFR, ErbB2, VEGFR-2, VEGFR-3 and IGF1R in a cell-free test system.	delphinidin	83-94	fms related receptor tyrosine kinase 4	Homo sapiens	176-183
19116149-0	2009	Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury.	delphinidin	33-44	signal transducer and activator of transcription 1	Homo sapiens	10-15
19584523-2	2009	We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Abeta-induced toxicity.	delphinidin	44-55	amyloid beta precursor protein	Rattus norvegicus	135-140
19584523-4	2009	However, treatment with delphinidin rescued PC12 cells from Abeta by attenuating the elevation of intracellular calcium levels and tau phosphorylation.	delphinidin	24-35	amyloid beta precursor protein	Rattus norvegicus	60-65
19584523-5	2009	Taken together, these results suggest that delphinidin protects PC12 cells against Abeta-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.	delphinidin	43-54	amyloid beta precursor protein	Rattus norvegicus	83-88
19174152-0	2009	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha.	delphinidin	43-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19174152-0	2009	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha.	delphinidin	43-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-93
19174152-0	2009	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha.	delphinidin	43-54	tumor necrosis factor	Homo sapiens	116-143
19174152-3	2009	Delphinidin strongly inhibited TNF-alpha-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells, whereas two other major phenolic compounds (resveratrol and gallic acid) did not exert significant inhibitory effects.	delphinidin	0-11	tumor necrosis factor	Homo sapiens	31-40
19174152-3	2009	Delphinidin strongly inhibited TNF-alpha-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells, whereas two other major phenolic compounds (resveratrol and gallic acid) did not exert significant inhibitory effects.	delphinidin	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	tumor necrosis factor	Homo sapiens	26-35
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	mitogen-activated protein kinase 8	Homo sapiens	64-67
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	mitogen-activated protein kinase 14	Homo sapiens	69-72
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	85-88
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	ribosomal protein S6 kinase A1	Homo sapiens	90-96
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	ribosomal protein S6 kinase A5	Homo sapiens	98-102
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	108-111
19174152-4	2009	Delphinidin inhibited the TNF-alpha-induced phosphorylations of JNK, p38 MAP kinase, Akt, p90RSK, MSK1, and ERK, and subsequently blocked the activation of the eukaryotic transcription factors AP-1 and NF-kappaB.	delphinidin	0-11	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	193-197
19174152-5	2009	Kinase and pull-down assay data revealed that delphinidin inhibited Fyn kinase activity and directly bound with Fyn kinase noncompetitively with ATP.	delphinidin	46-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
19174152-5	2009	Kinase and pull-down assay data revealed that delphinidin inhibited Fyn kinase activity and directly bound with Fyn kinase noncompetitively with ATP.	delphinidin	46-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
19174152-7	2009	Together these findings suggest that the targeted inhibition of Fyn kinase activity and COX-2 expression by delphinidin contributes to the chemopreventive potential of red wine and berries.	delphinidin	108-119	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
19174152-7	2009	Together these findings suggest that the targeted inhibition of Fyn kinase activity and COX-2 expression by delphinidin contributes to the chemopreventive potential of red wine and berries.	delphinidin	108-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
18729103-5	2009	We found that treatment of cells with delphinidin (30-240 microM; 48 h) resulted in (i) decrease in cell viability (ii) induction of apoptosis, (iii) cleavage of PARP, (iv) activation of caspases-3, -8, and -9, (v) increase in Bax with a concomitant decrease in Bcl-2 protein, and (vi) G2/M phase cell cycle arrest.	delphinidin	38-49	collagen type XI alpha 2 chain	Homo sapiens	162-166
18729103-5	2009	We found that treatment of cells with delphinidin (30-240 microM; 48 h) resulted in (i) decrease in cell viability (ii) induction of apoptosis, (iii) cleavage of PARP, (iv) activation of caspases-3, -8, and -9, (v) increase in Bax with a concomitant decrease in Bcl-2 protein, and (vi) G2/M phase cell cycle arrest.	delphinidin	38-49	caspase 3	Homo sapiens	187-209
18729103-5	2009	We found that treatment of cells with delphinidin (30-240 microM; 48 h) resulted in (i) decrease in cell viability (ii) induction of apoptosis, (iii) cleavage of PARP, (iv) activation of caspases-3, -8, and -9, (v) increase in Bax with a concomitant decrease in Bcl-2 protein, and (vi) G2/M phase cell cycle arrest.	delphinidin	38-49	BCL2 associated X, apoptosis regulator	Homo sapiens	227-230
18729103-5	2009	We found that treatment of cells with delphinidin (30-240 microM; 48 h) resulted in (i) decrease in cell viability (ii) induction of apoptosis, (iii) cleavage of PARP, (iv) activation of caspases-3, -8, and -9, (v) increase in Bax with a concomitant decrease in Bcl-2 protein, and (vi) G2/M phase cell cycle arrest.	delphinidin	38-49	BCL2 apoptosis regulator	Homo sapiens	262-267
18729103-7	2009	We therefore, determined the effect of delphinidin on NF-kappaB signaling pathway.	delphinidin	39-50	nuclear factor kappa B subunit 1	Homo sapiens	54-63
19116149-4	2009	Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation.	delphinidin	87-98	signal transducer and activator of transcription 1	Homo sapiens	185-190
19139002-6	2008	The activation of activator protein-1 and nuclear factor-kappaB induced by TPA was dose dependently inhibited by delphinidin treatment.	delphinidin	113-124	jun proto-oncogene	Mus musculus	18-37
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	v-raf-leukemia viral oncogene 1	Mus musculus	32-36
19139002-0	2008	Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling.	delphinidin	0-11	zinc fingers and homeoboxes 2	Mus musculus	95-98
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	mitogen-activated protein kinase kinase 1	Mus musculus	41-45
19139002-0	2008	Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling.	delphinidin	0-11	mitogen-activated protein kinase kinase 7	Homo sapiens	99-138
19139002-0	2008	Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling.	delphinidin	0-11	mitogen-activated protein kinase 1	Mus musculus	139-176
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	midkine	Mus musculus	41-44
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	prostaglandin-endoperoxide synthase 2	Mus musculus	116-132
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	mitogen-activated protein kinase 1	Mus musculus	128-165
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	prostaglandin-endoperoxide synthase 2	Mus musculus	134-139
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	mitogen-activated protein kinase 1	Mus musculus	167-170
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	zinc fingers and homeoboxes 2	Homo sapiens	237-240
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	mitogen-activated protein kinase kinase 7	Homo sapiens	245-284
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	ribosomal protein S6 kinase, polypeptide 2	Mus musculus	173-179
19139002-4	2008	Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter-induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells by directly targeting Raf and mitogen-activated protein kinase kinase (MEK).	delphinidin	21-32	mitogen-activated protein kinase kinase 7	Homo sapiens	286-289
19139002-5	2008	Delphinidin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation and COX-2 expression at both the protein and transcriptional levels.	delphinidin	0-11	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	delphinidin	0-11	salt inducible kinase 1	Mus musculus	185-188
19139002-8	2008	Although delphinidin suppressed ERK and c-Jun NH(2)-terminal kinase activities, it was more effective at inhibiting Raf1 or MEK1 activities.	delphinidin	9-20	mitogen-activated protein kinase 1	Mus musculus	32-35
19139002-8	2008	Although delphinidin suppressed ERK and c-Jun NH(2)-terminal kinase activities, it was more effective at inhibiting Raf1 or MEK1 activities.	delphinidin	9-20	v-raf-leukemia viral oncogene 1	Mus musculus	116-120
19139002-8	2008	Although delphinidin suppressed ERK and c-Jun NH(2)-terminal kinase activities, it was more effective at inhibiting Raf1 or MEK1 activities.	delphinidin	9-20	mitogen-activated protein kinase kinase 1	Mus musculus	124-128
19139002-9	2008	Pull-down and competition assays revealed that delphinidin binds with Raf1 or MEK1 noncompetitively with ATP.	delphinidin	47-58	v-raf-leukemia viral oncogene 1	Mus musculus	70-74
19139002-9	2008	Pull-down and competition assays revealed that delphinidin binds with Raf1 or MEK1 noncompetitively with ATP.	delphinidin	47-58	mitogen-activated protein kinase kinase 1	Mus musculus	78-82
19139002-10	2008	Delphinidin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor and H-Ras, both of which are involved in the activation of Raf/MEK/ERK signaling.	delphinidin	0-11	HRas proto-oncogene, GTPase	Homo sapiens	111-116
19139002-10	2008	Delphinidin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor and H-Ras, both of which are involved in the activation of Raf/MEK/ERK signaling.	delphinidin	0-11	zinc fingers and homeoboxes 2	Homo sapiens	166-169
19139002-10	2008	Delphinidin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor and H-Ras, both of which are involved in the activation of Raf/MEK/ERK signaling.	delphinidin	0-11	mitogen-activated protein kinase kinase 7	Homo sapiens	170-173
19139002-10	2008	Delphinidin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor and H-Ras, both of which are involved in the activation of Raf/MEK/ERK signaling.	delphinidin	0-11	mitogen-activated protein kinase 1	Homo sapiens	174-177
19139002-11	2008	Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables.	delphinidin	115-126	v-raf-leukemia viral oncogene 1	Mus musculus	67-71
19139002-11	2008	Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables.	delphinidin	115-126	prostaglandin-endoperoxide synthase 2	Mus musculus	95-100
18948740-2	2008	Extending these studies, we provide additional evidence that delphinidin induces apoptosis and cell cycle arrest in androgen refractory human PCa 22Rnu1 cells and that these effects are concomitant with inhibition of NFkappaB.	delphinidin	61-72	nuclear factor kappa B subunit 1	Homo sapiens	217-225
18948740-3	2008	We observed that delphinidin treatment to 22Rnu1 cells resulted in a dose-dependent (i) G(2)/M phase cell cycle arrest, (ii) induction of apoptosis (iii) and inhibition of NFkappaB signaling.	delphinidin	17-28	nuclear factor kappa B subunit 1	Homo sapiens	172-180
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	95-103
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	105-109
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	136-144
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	203-211
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	212-215
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	203-211
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	241-244
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	203-211
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	270-273
18948740-5	2008	Delphinidin treatment to cells resulted in a dose-dependent decrease in (i) phosphorylation of IKKgamma (NEMO), (ii) phosphorylation of NFkappaB inhibitory protein IkappaBalpha, (iii) phosphorylation of NFkappaB/p65 at Ser(536) and NFkappaB/p50 at Ser529, (iv) NFkappaB/p65 nuclear translocation, and (v) NFkappaB DNA binding activity.	delphinidin	0-11	nuclear factor kappa B subunit 1	Homo sapiens	203-211
18948740-6	2008	Taken together, our data show that delphinidin induces apoptosis of both androgen independent and androgen refractory human PCa cells via activation of caspases and in addition, this effect might be due to inhibition of NFkappaB signaling.	delphinidin	35-46	nuclear factor kappa B subunit 1	Homo sapiens	220-228
18922932-10	2008	Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA.	delphinidin	24-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
18922932-10	2008	Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA.	delphinidin	24-35	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	108-111
18922932-10	2008	Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA.	delphinidin	24-35	B cell leukemia/lymphoma 2	Mus musculus	113-117
18922932-10	2008	Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA.	delphinidin	24-35	antigen identified by monoclonal antibody Ki 67	Mus musculus	119-123
18922932-10	2008	Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA.	delphinidin	24-35	proliferating cell nuclear antigen	Mus musculus	129-133
18778064-3	2008	However, the DNA-damaging properties of delphinidin were decreased by the addition of catalase to the cell culture medium, counteracting delphinidin-mediated hydrogen peroxide formation.	delphinidin	40-51	catalase	Homo sapiens	86-94
18778064-3	2008	However, the DNA-damaging properties of delphinidin were decreased by the addition of catalase to the cell culture medium, counteracting delphinidin-mediated hydrogen peroxide formation.	delphinidin	137-148	catalase	Homo sapiens	86-94
18623129-0	2008	Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables.	delphinidin	68-79	epidermal growth factor receptor	Homo sapiens	14-46
18623129-4	2008	In our study, employing EGFR positive breast cancer AU-565 cells and immortalized MCF-10A cells, we evaluated the effect of delphinidin on EGFR and its downstream signaling pathways.	delphinidin	124-135	epidermal growth factor receptor	Homo sapiens	139-143
18623129-5	2008	Delphinidin (5-40 microM; 3 hr) treatment of both AU-565 cells and MCF-10A cells inhibited the (i) phosphorylation of EGFR, (ii) activation of PI3K, (iii) phosphorylation of AKT and MAPK.	delphinidin	0-11	epidermal growth factor receptor	Homo sapiens	118-122
18623129-5	2008	Delphinidin (5-40 microM; 3 hr) treatment of both AU-565 cells and MCF-10A cells inhibited the (i) phosphorylation of EGFR, (ii) activation of PI3K, (iii) phosphorylation of AKT and MAPK.	delphinidin	0-11	AKT serine/threonine kinase 1	Homo sapiens	174-177
18623129-6	2008	Further, delphinidin treatment of AU-565 cells inhibited EGF-induced autophosphorylation of EGFR, AKT and MAPK, activation of PI3K and cell invasion.	delphinidin	9-20	epidermal growth factor receptor	Homo sapiens	92-96
18623129-6	2008	Further, delphinidin treatment of AU-565 cells inhibited EGF-induced autophosphorylation of EGFR, AKT and MAPK, activation of PI3K and cell invasion.	delphinidin	9-20	AKT serine/threonine kinase 1	Homo sapiens	98-101
18623129-8	2008	Treatment of AU-565 cells with delphinidin resulted in (i) induction of apoptosis, (ii) cleavage of PARP protein, (iii) activation of caspase-3 and (iv) downregulation of Bcl-2 with an increase in the expression of Bax.	delphinidin	31-42	collagen type XI alpha 2 chain	Homo sapiens	100-104
18623129-8	2008	Treatment of AU-565 cells with delphinidin resulted in (i) induction of apoptosis, (ii) cleavage of PARP protein, (iii) activation of caspase-3 and (iv) downregulation of Bcl-2 with an increase in the expression of Bax.	delphinidin	31-42	caspase 3	Homo sapiens	134-143
18623129-8	2008	Treatment of AU-565 cells with delphinidin resulted in (i) induction of apoptosis, (ii) cleavage of PARP protein, (iii) activation of caspase-3 and (iv) downregulation of Bcl-2 with an increase in the expression of Bax.	delphinidin	31-42	BCL2 apoptosis regulator	Homo sapiens	171-176
18623129-8	2008	Treatment of AU-565 cells with delphinidin resulted in (i) induction of apoptosis, (ii) cleavage of PARP protein, (iii) activation of caspase-3 and (iv) downregulation of Bcl-2 with an increase in the expression of Bax.	delphinidin	31-42	BCL2 associated X, apoptosis regulator	Homo sapiens	215-218
18623129-9	2008	In summary, our study identifies a naturally occurring dietary agent delphinidin as an effective inhibitor of EGFR signaling in breast cancer cells.	delphinidin	69-80	epidermal growth factor receptor	Homo sapiens	110-114
18623129-10	2008	We suggest that delphinidin could be developed as an agent for the management of EGFR positive human cancers.	delphinidin	16-27	epidermal growth factor receptor	Homo sapiens	81-85