PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19878863-6	2009	Moreover, the anti-allodynic (mechanical and cold) effect was tested for systemic, intrathecal, or intraplantar treatment with the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	150-177	nuclear factor kappa B subunit 1	Homo sapiens	131-139
19811731-6	2009	Moreover, cell apoptosis with NF-kappaB activation was inhibited by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
19811731-6	2009	Moreover, cell apoptosis with NF-kappaB activation was inhibited by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
19546355-8	2009	Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-kappaB (NF-kappaB) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased.	pyrrolidine dithiocarbamic acid	154-189	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-114
19616539-6	2009	In addition, treatment of WI-38 cells with Bay 117082, an IkappaB phosphorylation inhibitor, and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, inhibited thrombin-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	97-124	coagulation factor II, thrombin	Homo sapiens	167-175
19616539-6	2009	In addition, treatment of WI-38 cells with Bay 117082, an IkappaB phosphorylation inhibitor, and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, inhibited thrombin-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	97-124	prostaglandin-endoperoxide synthase 2	Homo sapiens	184-189
19616539-6	2009	In addition, treatment of WI-38 cells with Bay 117082, an IkappaB phosphorylation inhibitor, and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, inhibited thrombin-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	126-130	coagulation factor II, thrombin	Homo sapiens	167-175
19616539-6	2009	In addition, treatment of WI-38 cells with Bay 117082, an IkappaB phosphorylation inhibitor, and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, inhibited thrombin-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	126-130	prostaglandin-endoperoxide synthase 2	Homo sapiens	184-189
19546355-8	2009	Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-kappaB (NF-kappaB) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased.	pyrrolidine dithiocarbamic acid	154-189	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
19546355-8	2009	Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-kappaB (NF-kappaB) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased.	pyrrolidine dithiocarbamic acid	191-195	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-114
19477486-8	2009	Pyrrolidine dithiocarbamate, a specific inhibitor of the NFkappaB pathway, inhibited the effects of LPS on CT in adult and cord WB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	57-65
19320561-4	2009	These effects were blunted in cells incubated with the NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC).	pyrrolidine dithiocarbamic acid	75-103	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
19320561-4	2009	These effects were blunted in cells incubated with the NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC).	pyrrolidine dithiocarbamic acid	105-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
19286451-7	2009	PDTC treatment effectively suppressed NF-kappaB signaling in APPswe/PS1dE9 mice as evidenced by the abolishment of COX-2 and TNFalpha induction.	pyrrolidine dithiocarbamic acid	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
19379726-0	2009	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	31-40
19379726-0	2009	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.	pyrrolidine dithiocarbamic acid	0-27	matrix metallopeptidase 1	Homo sapiens	64-69
19379726-0	2009	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.	pyrrolidine dithiocarbamic acid	0-27	matrix metallopeptidase 13	Homo sapiens	74-80
19379726-0	2009	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	84-92
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	64-73
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	84-111	matrix metallopeptidase 1	Homo sapiens	140-144
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	84-111	interleukin 1 beta	Homo sapiens	148-156
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	113-117	nuclear factor kappa B subunit 1	Homo sapiens	64-73
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	113-117	matrix metallopeptidase 1	Homo sapiens	140-144
19379726-2	2009	The objective of this study was to determine the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) on the expression of MMPs in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) of rheumatoid arthritis patients.	pyrrolidine dithiocarbamic acid	113-117	interleukin 1 beta	Homo sapiens	148-156
19286451-7	2009	PDTC treatment effectively suppressed NF-kappaB signaling in APPswe/PS1dE9 mice as evidenced by the abolishment of COX-2 and TNFalpha induction.	pyrrolidine dithiocarbamic acid	0-4	prostaglandin-endoperoxide synthase 2	Mus musculus	115-120
19286451-7	2009	PDTC treatment effectively suppressed NF-kappaB signaling in APPswe/PS1dE9 mice as evidenced by the abolishment of COX-2 and TNFalpha induction.	pyrrolidine dithiocarbamic acid	0-4	tumor necrosis factor	Mus musculus	125-133
19513610-1	2009	In order to find new drugs to inhibit nitric oxide (NO) production, the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor-kappa B (NF-kappaB) inhibitor, on recombinant human interleukin-1beta (rhIL-1beta)-induced NO production in chondrocytes were investigated.	pyrrolidine dithiocarbamic acid	83-110	interleukin 1 beta	Homo sapiens	188-205
19318426-3	2009	Ucn I mRNA levels were shown to be up-regulated by lipopolysaccarides (LPS), tumor necrosis factor-alpha (TNF-alpha), Ang II, H(2)O(2), and pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	140-166	urocortin	Homo sapiens	0-3
19318426-3	2009	Ucn I mRNA levels were shown to be up-regulated by lipopolysaccarides (LPS), tumor necrosis factor-alpha (TNF-alpha), Ang II, H(2)O(2), and pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	168-172	urocortin	Homo sapiens	0-3
19885037-3	2009	In order to elucidate the possible role of zinc influx in secretase-processed Abeta production, SH-SY5Y cells stably expressing amyloid precursor protein (APP) were treated with pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, and the resultant changes in APP processing were examined.	pyrrolidine dithiocarbamic acid	178-205	amyloid beta precursor protein	Homo sapiens	128-153
19429329-9	2009	The increased production of NO from rIFN-gamma plus CT-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	interferon gamma	Rattus norvegicus	36-46
19336001-0	2009	Pyrrolidine dithiocarbamate-induced activation of ERK and increased expression of c-Fos in mouse embryonic stem cells.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 1	Mus musculus	50-53
19407978-6	2009	Furthermore, the inhibition of TNF-alpha-induced monocyte adhesion was also mimicked by the specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	122-149	tumor necrosis factor	Homo sapiens	31-40
19407978-6	2009	Furthermore, the inhibition of TNF-alpha-induced monocyte adhesion was also mimicked by the specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	151-155	tumor necrosis factor	Homo sapiens	31-40
19336001-0	2009	Pyrrolidine dithiocarbamate-induced activation of ERK and increased expression of c-Fos in mouse embryonic stem cells.	pyrrolidine dithiocarbamic acid	0-27	FBJ osteosarcoma oncogene	Mus musculus	82-87
19242105-0	2009	Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice.	pyrrolidine dithiocarbamic acid	23-50	vascular endothelial growth factor A	Mus musculus	67-71
19242105-0	2009	Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice.	pyrrolidine dithiocarbamic acid	52-56	vascular endothelial growth factor A	Mus musculus	67-71
19147120-4	2009	The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%.	pyrrolidine dithiocarbamic acid	136-163	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-77
19147120-4	2009	The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%.	pyrrolidine dithiocarbamic acid	136-163	nuclear factor kappa B subunit 1	Homo sapiens	116-124
19147120-4	2009	The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%.	pyrrolidine dithiocarbamic acid	165-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-77
19147120-4	2009	The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%.	pyrrolidine dithiocarbamic acid	165-169	nuclear factor kappa B subunit 1	Homo sapiens	116-124
18988672-4	2009	STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide.	pyrrolidine dithiocarbamic acid	169-196	signal transducer and activator of transcription 3	Homo sapiens	0-5
19239475-5	2009	Proliferation was also blocked by inhibition of the tyrosine kinase Src with PP2, phospholipase C (PLC) with U73122, extracellular signal-regulated kinase (ERK) with PD98059 or nuclear factor-kappa B (NF-kB) activation with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	224-251	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
19239475-5	2009	Proliferation was also blocked by inhibition of the tyrosine kinase Src with PP2, phospholipase C (PLC) with U73122, extracellular signal-regulated kinase (ERK) with PD98059 or nuclear factor-kappa B (NF-kB) activation with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	253-257	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
18988672-8	2009	Cellular GRX-1 activity was inhibited by diamide and pyrrolidine dithiocarbamate treatment; however, ectopic expression of GRX-1 was accompanied by a modest increase in phosphorylation, nuclear translocation, and DNA-binding ability of STAT3 in response to IL-6.	pyrrolidine dithiocarbamic acid	53-80	glutaredoxin	Homo sapiens	9-14
18988672-4	2009	STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide.	pyrrolidine dithiocarbamic acid	169-196	signal transducer and activator of transcription 3	Homo sapiens	113-118
18937212-2	2009	Several inhibitors of NF-kappaB, like caffeic acid, captopril, curcumin, pyrrolidine dithiocarbamate, resveratrol, silymarin and thalidomide, have demonstrated antinecrotic, anticholestatic, antifibrotic and anticancer activities in the liver.	pyrrolidine dithiocarbamic acid	73-100	nuclear factor kappa B subunit 1	Homo sapiens	22-31
19882112-0	2009	Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	58-80
18951928-1	2009	We show that treatment with non-toxic doses of zinc in association to the ionophore compound pyrrolidine dithiocarbamate (PDTC) inhibits p53(-/-) pancreatic cancer cell growth much more efficiently than gemcitabine, the gold standard chemotherapeutic agent for pancreatic cancer.	pyrrolidine dithiocarbamic acid	93-120	tumor protein p53	Homo sapiens	137-140
18951928-1	2009	We show that treatment with non-toxic doses of zinc in association to the ionophore compound pyrrolidine dithiocarbamate (PDTC) inhibits p53(-/-) pancreatic cancer cell growth much more efficiently than gemcitabine, the gold standard chemotherapeutic agent for pancreatic cancer.	pyrrolidine dithiocarbamic acid	122-126	tumor protein p53	Homo sapiens	137-140
18951928-3	2009	Zn/PDTC treatment induces a strong apoptotic cell death that is associated to ROS-dependent nuclear translocation of the mitochondrial factor AIF, but not to the regulation of apoptotic genes and caspase activation.	pyrrolidine dithiocarbamic acid	3-7	apoptosis inducing factor mitochondria associated 1	Homo sapiens	142-145
19087874-7	2009	Reactive oxygen species signaling pathway inhibitor pyrrolidine dithiocarbamate (PDTC) inhibited reactive oxygen species generation and NF-kappaB activation, which in turn blocked LTC(4)S expression and attenuated the injury.	pyrrolidine dithiocarbamic acid	52-79	leukotriene C4 synthase	Homo sapiens	180-187
19087874-7	2009	Reactive oxygen species signaling pathway inhibitor pyrrolidine dithiocarbamate (PDTC) inhibited reactive oxygen species generation and NF-kappaB activation, which in turn blocked LTC(4)S expression and attenuated the injury.	pyrrolidine dithiocarbamic acid	81-85	leukotriene C4 synthase	Homo sapiens	180-187
19882112-3	2009	In this study, we tested the anti-angiogenic properties of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, using established in vitro and ex vivo assays in human umbilical vein endothelial cells (HUVEC) and human metastatic RCC cell lines (ACHN and SN12K1).	pyrrolidine dithiocarbamic acid	59-86	nuclear factor kappa B subunit 1	Homo sapiens	97-106
19882112-3	2009	In this study, we tested the anti-angiogenic properties of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, using established in vitro and ex vivo assays in human umbilical vein endothelial cells (HUVEC) and human metastatic RCC cell lines (ACHN and SN12K1).	pyrrolidine dithiocarbamic acid	88-92	nuclear factor kappa B subunit 1	Homo sapiens	97-106
18590811-5	2008	Bacterial lipopolysaccharide (LPS) stimulated the expression of CD11b in mouse BV-2 microglial cells and primary microglia, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	203-230	integrin subunit alpha M	Homo sapiens	64-69
19129732-10	2009	Edaravone and pyrrolidine dithiocarbamate (a specific NF-kappaB inhibitor) protected endothelial cells from the OGD-induced injury.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor kappa B subunit 1	Homo sapiens	54-63
19246800-9	2008	The increased production of NO from rIFN-gamma plus PC-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	interferon gamma	Rattus norvegicus	36-46
19246800-9	2008	The increased production of NO from rIFN-gamma plus PC-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	155-159	interferon gamma	Rattus norvegicus	36-46
18841173-3	2008	The increased production of NO from rIFN-gamma plus LS-stimulated cells was almost completely inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	125-152	interferon gamma	Rattus norvegicus	36-46
18841173-3	2008	The increased production of NO from rIFN-gamma plus LS-stimulated cells was almost completely inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	154-158	interferon gamma	Rattus norvegicus	36-46
19272247-0	2008	[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].	pyrrolidine dithiocarbamic acid	14-41	transforming growth factor, beta 1	Rattus norvegicus	66-100
19272247-0	2008	[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].	pyrrolidine dithiocarbamic acid	14-41	matrix metallopeptidase 2	Rattus norvegicus	102-128
19272247-0	2008	[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].	pyrrolidine dithiocarbamic acid	43-47	transforming growth factor, beta 1	Rattus norvegicus	66-100
19272247-0	2008	[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].	pyrrolidine dithiocarbamic acid	43-47	matrix metallopeptidase 2	Rattus norvegicus	102-128
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	43-70	transforming growth factor, beta 1	Rattus norvegicus	99-133
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	43-70	transforming growth factor, beta 1	Rattus norvegicus	135-146
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	43-70	matrix metallopeptidase 2	Rattus norvegicus	149-175
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	43-70	matrix metallopeptidase 2	Rattus norvegicus	177-182
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	72-76	transforming growth factor, beta 1	Rattus norvegicus	99-133
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	72-76	transforming growth factor, beta 1	Rattus norvegicus	135-146
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	72-76	matrix metallopeptidase 2	Rattus norvegicus	149-175
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	72-76	matrix metallopeptidase 2	Rattus norvegicus	177-182
19272247-1	2008	OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta(1) (TGF-beta(1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).	pyrrolidine dithiocarbamic acid	72-76	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	229-235
18972404-9	2008	Recombinant OPN was found to induce translocation of p65 into the nucleus of HCC cells and activation of MMP-2 and MEK/ERK/1/2, which were suppressed by the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	201-228	secreted phosphoprotein 1	Homo sapiens	12-15
18972404-9	2008	Recombinant OPN was found to induce translocation of p65 into the nucleus of HCC cells and activation of MMP-2 and MEK/ERK/1/2, which were suppressed by the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	201-228	mitogen-activated protein kinase 3	Homo sapiens	119-126
18972404-9	2008	Recombinant OPN was found to induce translocation of p65 into the nucleus of HCC cells and activation of MMP-2 and MEK/ERK/1/2, which were suppressed by the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	201-228	nuclear factor kappa B subunit 1	Homo sapiens	172-178
18972404-9	2008	Recombinant OPN was found to induce translocation of p65 into the nucleus of HCC cells and activation of MMP-2 and MEK/ERK/1/2, which were suppressed by the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	201-228	nuclear factor kappa B subunit 1	Homo sapiens	180-189
18602210-8	2008	Attenuation of constitutive NF-kappaB activity by pretreatment with pyrrolidine dithiocarbamate (PDTC), an NF-kappaB nuclear translocation inhibitor, induced significantly apoptosis in the presence of PTX-2.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor kappa B subunit 1	Homo sapiens	28-37
18602210-8	2008	Attenuation of constitutive NF-kappaB activity by pretreatment with pyrrolidine dithiocarbamate (PDTC), an NF-kappaB nuclear translocation inhibitor, induced significantly apoptosis in the presence of PTX-2.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor kappa B subunit 1	Homo sapiens	107-116
18602210-8	2008	Attenuation of constitutive NF-kappaB activity by pretreatment with pyrrolidine dithiocarbamate (PDTC), an NF-kappaB nuclear translocation inhibitor, induced significantly apoptosis in the presence of PTX-2.	pyrrolidine dithiocarbamic acid	97-101	nuclear factor kappa B subunit 1	Homo sapiens	28-37
18602210-8	2008	Attenuation of constitutive NF-kappaB activity by pretreatment with pyrrolidine dithiocarbamate (PDTC), an NF-kappaB nuclear translocation inhibitor, induced significantly apoptosis in the presence of PTX-2.	pyrrolidine dithiocarbamic acid	97-101	nuclear factor kappa B subunit 1	Homo sapiens	107-116
18728240-6	2008	Furthermore, cotreatment with CLT and pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, synergistically reduced the NF-kappaB transcriptional activity as well as IL-8 expression.	pyrrolidine dithiocarbamic acid	38-65	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
18830732-6	2008	Production of CXCL16 increased by lysoPtdOH and LPS from macrophages was inhibited around 70% by Pertussis toxin (G(i/o) specific inhibitor), exoC3 (Rho specific inhibitor), and pyrrolidine dithiocarbamate (the NF-kappaB-dependent pathway inhibitor) separately.	pyrrolidine dithiocarbamic acid	178-205	C-X-C motif chemokine ligand 16	Homo sapiens	14-20
18722366-8	2008	Ischemia and reperfusion significantly increased the mRNA expression of the endothelin-1 and endothelin ET(B) receptor, which was prevented by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	143-170	endothelin 1	Rattus norvegicus	76-88
18671963-0	2008	Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex.	pyrrolidine dithiocarbamic acid	97-124	mitogen-activated protein kinase 8	Homo sapiens	48-51
18671963-5	2008	Additional studies showed that PDTC/Cu complex significantly decreased mitochondrial membrane potential, increased cytochrome c release, and reactive oxygen species production, and depleted reduced non-protein thiols in a time-dependent manner.	pyrrolidine dithiocarbamic acid	31-35	cytochrome c, somatic	Homo sapiens	115-127
18671963-6	2008	Following oxidative stress, the PDTC/Cu complex sequentially activated JNK, NF-kappaB and AP-1 signaling pathways while IkappaB kinase activity was enhanced.	pyrrolidine dithiocarbamic acid	32-36	mitogen-activated protein kinase 8	Homo sapiens	71-74
18671963-9	2008	Based on these findings; we conclude that PDTC/Cu complex-induced apoptosis is mediated by activation of JNK, NF-kappaB, AP-1 and caspase 3.	pyrrolidine dithiocarbamic acid	42-46	mitogen-activated protein kinase 8	Homo sapiens	105-108
18671963-9	2008	Based on these findings; we conclude that PDTC/Cu complex-induced apoptosis is mediated by activation of JNK, NF-kappaB, AP-1 and caspase 3.	pyrrolidine dithiocarbamic acid	42-46	caspase 3	Homo sapiens	130-139
18632801-7	2008	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity.	pyrrolidine dithiocarbamic acid	25-52	nuclear factor kappa B subunit 1	Homo sapiens	4-13
18632801-7	2008	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity.	pyrrolidine dithiocarbamic acid	25-52	tumor necrosis factor	Homo sapiens	120-129
18632801-7	2008	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity.	pyrrolidine dithiocarbamic acid	54-58	nuclear factor kappa B subunit 1	Homo sapiens	4-13
18632801-7	2008	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented these increases and significantly attenuated the TNF-alpha-induced cytotoxicity.	pyrrolidine dithiocarbamic acid	54-58	tumor necrosis factor	Homo sapiens	120-129
18723768-7	2008	FIP plasma-induced oxidant stress, occludin rearrangement, and MCVEC permeability were effectively attenuated by antioxidant, 1-pyrrolidinecarbodithioic acid (PDTC; 0.5 mM), or interfering with nitric oxide synthase (NOS) activity [0.1 mM nitro-L-arginine methyl ester (L-NAME) or endothelial NOS (eNOS)-deficient MCVEC].	pyrrolidine dithiocarbamic acid	159-163	occludin	Mus musculus	35-43
18723768-7	2008	FIP plasma-induced oxidant stress, occludin rearrangement, and MCVEC permeability were effectively attenuated by antioxidant, 1-pyrrolidinecarbodithioic acid (PDTC; 0.5 mM), or interfering with nitric oxide synthase (NOS) activity [0.1 mM nitro-L-arginine methyl ester (L-NAME) or endothelial NOS (eNOS)-deficient MCVEC].	pyrrolidine dithiocarbamic acid	159-163	nitric oxide synthase 1, neuronal	Mus musculus	194-215
18723768-7	2008	FIP plasma-induced oxidant stress, occludin rearrangement, and MCVEC permeability were effectively attenuated by antioxidant, 1-pyrrolidinecarbodithioic acid (PDTC; 0.5 mM), or interfering with nitric oxide synthase (NOS) activity [0.1 mM nitro-L-arginine methyl ester (L-NAME) or endothelial NOS (eNOS)-deficient MCVEC].	pyrrolidine dithiocarbamic acid	159-163	nitric oxide synthase 3, endothelial cell	Mus musculus	281-296
18590811-5	2008	Bacterial lipopolysaccharide (LPS) stimulated the expression of CD11b in mouse BV-2 microglial cells and primary microglia, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	232-236	integrin subunit alpha M	Homo sapiens	64-69
18590811-6	2008	Furthermore, comicroinjection of either NAC or PDTC with LPS was also able to suppress LPS-stimulated expression of CD11b in striatum in vivo.	pyrrolidine dithiocarbamic acid	47-51	integrin alpha M	Mus musculus	116-121
18661398-2	2008	In this study, cell growth inhibition on human Burkitt lymphoma cell lines CA46 and Raji were obtained with either srhCD40L or pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of NF-kappaB, whereas converse effects on CD40 negative control.	pyrrolidine dithiocarbamic acid	127-154	nuclear factor kappa B subunit 1	Homo sapiens	187-196
18601919-0	2008	Protective effects of pyrrolidine dithiocarbamate against airway inflammation in the ovalbumin-induced mouse model.	pyrrolidine dithiocarbamic acid	22-49	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	85-94
18177935-7	2008	In addition, the NF-kappaB inhibitors (pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin) suppress the TPA-induced MMP-9 enzyme activity.	pyrrolidine dithiocarbamic acid	39-65	nuclear factor kappa B subunit 1	Homo sapiens	17-26
18687761-3	2008	Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-kappaB activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan.	pyrrolidine dithiocarbamic acid	154-181	angiotensinogen	Homo sapiens	18-24
18687761-3	2008	Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-kappaB activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan.	pyrrolidine dithiocarbamic acid	154-181	bone morphogenetic protein 2	Homo sapiens	59-64
18687761-3	2008	Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-kappaB activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan.	pyrrolidine dithiocarbamic acid	183-187	angiotensinogen	Homo sapiens	18-24
18687761-3	2008	Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-kappaB activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan.	pyrrolidine dithiocarbamic acid	183-187	bone morphogenetic protein 2	Homo sapiens	59-64
18593918-8	2008	Treatment of MDA-MB-231 cells with pyrrolidine dithiocarbamate, an inhibitor of p65, or small interfering RNA knockdown of p65, blocked RON gene expression and MSP-mediated invasion of MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	35-62	RELA proto-oncogene, NF-kB subunit	Homo sapiens	80-83
18593918-8	2008	Treatment of MDA-MB-231 cells with pyrrolidine dithiocarbamate, an inhibitor of p65, or small interfering RNA knockdown of p65, blocked RON gene expression and MSP-mediated invasion of MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	35-62	macrophage stimulating 1	Homo sapiens	160-163
18397269-4	2008	These PAF effects were inhibited to a significant degree by pretreatment with the nuclear factor-kappaB inhibitor, pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	115-141	patchy fur	Mus musculus	6-9
18177935-7	2008	In addition, the NF-kappaB inhibitors (pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin) suppress the TPA-induced MMP-9 enzyme activity.	pyrrolidine dithiocarbamic acid	39-65	matrix metallopeptidase 9	Homo sapiens	121-126
18474243-0	2008	Transcriptional regulation of the hepatocyte growth factor gene by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	67-94	hepatocyte growth factor	Homo sapiens	34-58
18474243-2	2008	This study characterised the down-regulation of HGF expression by pyrrolidine dithiocarbamate (PDTC), which markedly reduced HGF mRNA expression and protein production in MRC-5 cells.	pyrrolidine dithiocarbamic acid	66-93	hepatocyte growth factor	Homo sapiens	48-51
18474243-2	2008	This study characterised the down-regulation of HGF expression by pyrrolidine dithiocarbamate (PDTC), which markedly reduced HGF mRNA expression and protein production in MRC-5 cells.	pyrrolidine dithiocarbamic acid	66-93	hepatocyte growth factor	Homo sapiens	125-128
18474243-2	2008	This study characterised the down-regulation of HGF expression by pyrrolidine dithiocarbamate (PDTC), which markedly reduced HGF mRNA expression and protein production in MRC-5 cells.	pyrrolidine dithiocarbamic acid	95-99	hepatocyte growth factor	Homo sapiens	48-51
18474243-2	2008	This study characterised the down-regulation of HGF expression by pyrrolidine dithiocarbamate (PDTC), which markedly reduced HGF mRNA expression and protein production in MRC-5 cells.	pyrrolidine dithiocarbamic acid	95-99	hepatocyte growth factor	Homo sapiens	125-128
18384434-6	2008	Overexpression of mIkappaBalpha or pyrrolidine dithiocarbamate pretreatment decreased the DOX resistance in SNU-601 cells with low MnSOD expression, but not in SNU-216 cells with high MnSOD expression.	pyrrolidine dithiocarbamic acid	35-62	superoxide dismutase 2	Homo sapiens	131-136
18441463-10	2008	Ox-LDL treatment significantly increased BMP-2 expression, which is associated with NF-kappaB activation, but BMP-2 expression was suppressed by treatment with PDTC or atorvastatin.	pyrrolidine dithiocarbamic acid	160-164	bone morphogenetic protein 2	Homo sapiens	110-115
18215436-0	2008	Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis.	pyrrolidine dithiocarbamic acid	24-51	tumor necrosis factor	Mus musculus	55-64
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	79-88
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	27-54	tumor necrosis factor	Homo sapiens	98-107
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	27-54	intercellular adhesion molecule 1	Homo sapiens	116-122
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	183-192
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	27-54	tumor necrosis factor	Homo sapiens	219-228
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-60	nuclear factor kappa B subunit 1	Homo sapiens	79-88
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-60	tumor necrosis factor	Homo sapiens	98-107
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-60	intercellular adhesion molecule 1	Homo sapiens	116-122
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-60	nuclear factor kappa B subunit 1	Homo sapiens	183-192
18446055-8	2008	Finally, pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, reduced TNF-alpha-induced ICAM-1 expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-60	tumor necrosis factor	Homo sapiens	219-228
18178561-8	2008	Consistent with this, ammonium pyrrolidine dithiocarbamate, a pharmacological inhibitor of NF-kappaB, blocks TRAIL-induced IGF1R expression, and p65 overexpression increases IGF1R protein levels.	pyrrolidine dithiocarbamic acid	22-58	nuclear factor kappa B subunit 1	Homo sapiens	91-100
18178561-8	2008	Consistent with this, ammonium pyrrolidine dithiocarbamate, a pharmacological inhibitor of NF-kappaB, blocks TRAIL-induced IGF1R expression, and p65 overexpression increases IGF1R protein levels.	pyrrolidine dithiocarbamic acid	22-58	TNF superfamily member 10	Homo sapiens	109-114
18178561-8	2008	Consistent with this, ammonium pyrrolidine dithiocarbamate, a pharmacological inhibitor of NF-kappaB, blocks TRAIL-induced IGF1R expression, and p65 overexpression increases IGF1R protein levels.	pyrrolidine dithiocarbamic acid	22-58	insulin like growth factor 1 receptor	Homo sapiens	123-128
18666436-8	2008	PDTC (pyrrolidine dithiocarbamate)--NFkappaB inhibitor made ME18/R cells more sensitive to ANN and WP903 but did not affect cytotoxicity of DOX in ME18 cells.	pyrrolidine dithiocarbamic acid	0-4	nuclear factor kappa B subunit 1	Homo sapiens	36-44
18666436-8	2008	PDTC (pyrrolidine dithiocarbamate)--NFkappaB inhibitor made ME18/R cells more sensitive to ANN and WP903 but did not affect cytotoxicity of DOX in ME18 cells.	pyrrolidine dithiocarbamic acid	6-33	nuclear factor kappa B subunit 1	Homo sapiens	36-44
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	72-99	brain derived neurotrophic factor	Homo sapiens	4-8
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	72-99	matrix metallopeptidase 9	Homo sapiens	31-36
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	72-99	nuclear factor kappa B subunit 1	Homo sapiens	110-119
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	72-99	brain derived neurotrophic factor	Homo sapiens	210-214
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	101-105	brain derived neurotrophic factor	Homo sapiens	4-8
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	101-105	matrix metallopeptidase 9	Homo sapiens	31-36
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	101-105	neurotrophic receptor tyrosine kinase 2	Homo sapiens	179-183
18843978-5	2008	The BDNF-induced activation of MMP-9 was inhibited by pretreatment with pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, or K252 alpha, a specific tyrosine inhibitor of TrkB which is the receptor for BDNF.	pyrrolidine dithiocarbamic acid	101-105	brain derived neurotrophic factor	Homo sapiens	210-214
18843978-6	2008	Pretreated with 1 mmol/L PDTC or 500 nmol/L K252 alpha significantly downregulated MMP-9 secreted by the 100 microg/L of BDNF stimulated RPMI 8226 cells (the optical density values were 867.52+/-101.81 and 727.98 +/-92.05, respectively, vs 1,159.01+/-233.15 of the control).	pyrrolidine dithiocarbamic acid	25-29	matrix metallopeptidase 9	Homo sapiens	83-88
18843978-6	2008	Pretreated with 1 mmol/L PDTC or 500 nmol/L K252 alpha significantly downregulated MMP-9 secreted by the 100 microg/L of BDNF stimulated RPMI 8226 cells (the optical density values were 867.52+/-101.81 and 727.98 +/-92.05, respectively, vs 1,159.01+/-233.15 of the control).	pyrrolidine dithiocarbamic acid	25-29	brain derived neurotrophic factor	Homo sapiens	121-125
18177344-7	2008	The DNA-binding activity of NF-kappaB and AP-1 was also assessed by an electrophoretic mobility gel shift assay, and an NF-kappaB specific inhibitor, pyrrolidine dithiocarbamate, profoundly inhibited the synthesis and production of the proinflammatory cytokines.	pyrrolidine dithiocarbamic acid	150-177	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-46
17588735-5	2008	Interestingly, pyrrolidine dithiocarbamate (for NF-kappaB inhibitor) and Nomega-nitro-l-arginine methylester hydrochloride (for NO inhibitor) effectively stimulated the caspase-3 activation and induced apoptosis in Hep3B cells.	pyrrolidine dithiocarbamic acid	15-42	nuclear factor kappa B subunit 1	Homo sapiens	48-57
18215436-1	2008	BACKGROUND/AIMS: Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	17-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-93
18215436-1	2008	BACKGROUND/AIMS: Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	17-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
18215436-1	2008	BACKGROUND/AIMS: Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	46-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-93
18215436-1	2008	BACKGROUND/AIMS: Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	46-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
17767925-9	2008	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate resulted in significant suppression of TPA-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor kappa B subunit 1	Homo sapiens	28-37
17588735-5	2008	Interestingly, pyrrolidine dithiocarbamate (for NF-kappaB inhibitor) and Nomega-nitro-l-arginine methylester hydrochloride (for NO inhibitor) effectively stimulated the caspase-3 activation and induced apoptosis in Hep3B cells.	pyrrolidine dithiocarbamic acid	15-42	caspase 3	Homo sapiens	169-178
18479063-3	2008	We also analyzed the activation of NF-kappaB and the effects of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, on M. penetrans LAMPs-induced mouse macrophages apoptosis by indirect immunofluorescence and Western blotting.	pyrrolidine dithiocarbamic acid	93-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
18388985-8	2008	The activation of NFkappaB and M. penetrans LAMPs-induced apoptosis in mouse macrophages was partially inhibited by the NFkappaB-specific inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	148-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-26
18388985-8	2008	The activation of NFkappaB and M. penetrans LAMPs-induced apoptosis in mouse macrophages was partially inhibited by the NFkappaB-specific inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	148-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-128
17767925-9	2008	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate resulted in significant suppression of TPA-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	48-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
18208665-7	2008	In contrast, the activations of NF-kappaB and JAK-STAT were blocked by losartan, pyrrolidinedithiocarbamate (a specific inhibitor of NF-kappaB) and AG490 (a specific inhibitor of the JAK2 tyrosine kinase).	pyrrolidine dithiocarbamic acid	81-107	nuclear factor kappa B subunit 1	Homo sapiens	32-41
18208665-7	2008	In contrast, the activations of NF-kappaB and JAK-STAT were blocked by losartan, pyrrolidinedithiocarbamate (a specific inhibitor of NF-kappaB) and AG490 (a specific inhibitor of the JAK2 tyrosine kinase).	pyrrolidine dithiocarbamic acid	81-107	nuclear factor kappa B subunit 1	Homo sapiens	133-142
18208665-7	2008	In contrast, the activations of NF-kappaB and JAK-STAT were blocked by losartan, pyrrolidinedithiocarbamate (a specific inhibitor of NF-kappaB) and AG490 (a specific inhibitor of the JAK2 tyrosine kinase).	pyrrolidine dithiocarbamic acid	81-107	Janus kinase 2	Homo sapiens	183-187
18354251-6	2008	The effect of NFkappaB activation on HES5 transcription was studied using the NFkappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	97-124	hes family bHLH transcription factor 5	Homo sapiens	37-41
18163503-4	2008	METHODS: Human articular chondrocytes were treated with IL-1beta in the presence of TGFbeta1, pyrrolidine dithiocarbamate (a repressor of the NF-kappaB pathway), or cycloheximide.	pyrrolidine dithiocarbamic acid	94-121	interleukin 1 beta	Homo sapiens	56-64
18163503-4	2008	METHODS: Human articular chondrocytes were treated with IL-1beta in the presence of TGFbeta1, pyrrolidine dithiocarbamate (a repressor of the NF-kappaB pathway), or cycloheximide.	pyrrolidine dithiocarbamic acid	94-121	nuclear factor kappa B subunit 1	Homo sapiens	142-151
18354251-6	2008	The effect of NFkappaB activation on HES5 transcription was studied using the NFkappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	97-124	nuclear factor kappa B subunit 1	Homo sapiens	78-86
17898021-12	2008	Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished (P<0.01) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 (P<0.01).	pyrrolidine dithiocarbamic acid	162-189	interleukin 6	Homo sapiens	40-44
18346929-9	2008	Similar levels of epidermal growth factor receptor activation were observed with alternative lipid permeable metal-ligands including neocuproine and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	149-176	epidermal growth factor receptor	Homo sapiens	18-50
17898021-12	2008	Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished (P<0.01) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 (P<0.01).	pyrrolidine dithiocarbamic acid	162-189	tumor necrosis factor	Homo sapiens	49-58
17898021-12	2008	Furthermore, the increased synthesis of IL-6 and TNF-alpha by anionic pIgA in HMC was significantly diminished (P<0.01) in the presence of NF-kappaB inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 (P<0.01).	pyrrolidine dithiocarbamic acid	162-189	nuclear factor kappa B subunit 1	Homo sapiens	142-151
19920873-6	2008	Finally, pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-kappaB) and inhibitor kappa B alpha (IkappaBalpha) mutant (IkappaBalphaM, a specific inhibitor of NF-kappaB) abrogated the EGF-induced NF-kappaB activity and cell survival.	pyrrolidine dithiocarbamic acid	9-36	epidermal growth factor like 1	Rattus norvegicus	186-189
18322419-8	2008	As paclitaxel treatment produced reactive oxygen species (ROS), VEGF expression was increased by H2O2 treatment and reduced by various ROS scavengers such as N-acetyl-L-cysteine, pyrrolidine dithiocarbamate and diphenylene iodonium.	pyrrolidine dithiocarbamic acid	179-206	vascular endothelial growth factor A	Homo sapiens	64-68
18510246-1	2008	OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on Lipopolysaccharide (LPS)-mediated activation of nuclear factor kappa B (NF-kappaB) and cytokine expression in cultured human corneal fibroblasts.	pyrrolidine dithiocarbamic acid	41-68	nuclear factor kappa B subunit 1	Homo sapiens	127-149
18510246-1	2008	OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on Lipopolysaccharide (LPS)-mediated activation of nuclear factor kappa B (NF-kappaB) and cytokine expression in cultured human corneal fibroblasts.	pyrrolidine dithiocarbamic acid	41-68	nuclear factor kappa B subunit 1	Homo sapiens	151-160
18510246-1	2008	OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on Lipopolysaccharide (LPS)-mediated activation of nuclear factor kappa B (NF-kappaB) and cytokine expression in cultured human corneal fibroblasts.	pyrrolidine dithiocarbamic acid	70-74	nuclear factor kappa B subunit 1	Homo sapiens	127-149
18510246-1	2008	OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on Lipopolysaccharide (LPS)-mediated activation of nuclear factor kappa B (NF-kappaB) and cytokine expression in cultured human corneal fibroblasts.	pyrrolidine dithiocarbamic acid	70-74	nuclear factor kappa B subunit 1	Homo sapiens	151-160
18478929-7	2007	Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	114-141	epidermal growth factor	Homo sapiens	13-16
18478929-7	2007	Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	114-141	nuclear factor kappa B subunit 1	Homo sapiens	32-41
18478929-7	2007	Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	114-141	nuclear factor kappa B subunit 1	Homo sapiens	93-102
18478929-7	2007	Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	114-141	epidermal growth factor	Homo sapiens	163-166
18478929-7	2007	Furthermore, EGF stimulated the NF-kappaB binding activity, and pretreatment of cells with a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	114-141	nuclear factor kappa B subunit 1	Homo sapiens	93-102
17855340-10	2007	Further, FN potentiated Caco2-BBE cell attachment and wound healing, which was inhibited by RGD peptide as well as NF-kappaB inhibitors MG-132 and 1-pyrrolidinecarbodithioic acid, ammonium salt.	pyrrolidine dithiocarbamic acid	147-178	fibronectin 1	Homo sapiens	9-11
17991490-8	2007	Benzo(a)pyrene-augmented iNOS expression and activity in PMNs were significantly reverse by felodipine, genistein, or PDTC.	pyrrolidine dithiocarbamic acid	118-122	nitric oxide synthase 2	Rattus norvegicus	25-29
17680773-6	2007	We report that different classes of metal ligands including 8HQ and phenanthroline derivatives and the sulfur compound PDTC (pyrrolidine dithiocarbamate) elevated cellular metal levels (copper and zinc), and resulted in substantial loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	119-123	amyloid beta precursor protein	Homo sapiens	249-254
17680773-6	2007	We report that different classes of metal ligands including 8HQ and phenanthroline derivatives and the sulfur compound PDTC (pyrrolidine dithiocarbamate) elevated cellular metal levels (copper and zinc), and resulted in substantial loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	125-152	amyloid beta precursor protein	Homo sapiens	249-254
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	99-103	amyloid beta precursor protein	Homo sapiens	29-34
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	99-103	mitogen-activated protein kinase 8	Homo sapiens	152-155
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	99-103	mitogen-activated protein kinase 8	Homo sapiens	170-173
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	pyrrolidine dithiocarbamic acid	99-103	amyloid beta precursor protein	Homo sapiens	257-262
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	89-116	nitric oxide synthase 2	Homo sapiens	22-26
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	89-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	118-122	nitric oxide synthase 2	Homo sapiens	22-26
17825288-10	2007	Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	118-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	16-42	tumor necrosis factor	Homo sapiens	116-125
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	0-26	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	73-76
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	0-26	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	82-85
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	0-26	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	82-85
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	28-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	73-76
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	28-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	82-85
17924369-1	2007	Pyrrolidinedithiocarbamate (PDTC) chelates of Zn(II), Cu(II), Ni(II), Co(III), Fe(III), Mn(II), Cr(III), and VO(II) were analysed by capillary GC on a DB-1701 column (30 m x 0.25 mm id) with flame ionisation detection (FID).	pyrrolidine dithiocarbamic acid	28-33	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	82-85
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	16-42	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	16-42	interferon gamma	Homo sapiens	141-150
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	44-48	tumor necrosis factor	Homo sapiens	116-125
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	44-48	interleukin 1 beta	Homo sapiens	127-136
17765224-7	2007	ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05).	pyrrolidine dithiocarbamic acid	44-48	interferon gamma	Homo sapiens	141-150
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	0-27	angiotensinogen	Rattus norvegicus	90-96
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	pyrrolidine dithiocarbamic acid	102-129	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	pyrrolidine dithiocarbamic acid	102-129	nuclear factor kappa B subunit 1	Homo sapiens	147-156
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	154-181
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	0-27	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	205-224
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	29-33	angiotensinogen	Rattus norvegicus	90-96
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	29-33	tumor necrosis factor	Rattus norvegicus	154-181
17762659-4	2007	Pyrrolidine dithiocarbamate (PDTC) (100 mg/kg per day), an NF-kappaB inhibitor, abolished Ang II-induced NF-kappaB activation and concomitant increase in tumor necrosis factor-alpha gene expression, while activator protein-1/DNA binding was not affected.	pyrrolidine dithiocarbamic acid	29-33	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	205-224
17608808-4	2007	The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors).	pyrrolidine dithiocarbamic acid	198-225	interleukin 1 beta	Homo sapiens	15-32
17673717-6	2007	Effects of minocycline, a nonspecific MMP inhibitor, and pyrrolidine dithiocarbamate, an upstream regulator of MMPs, on MMP-9 activity and thereby the degree of ICH were also tested.	pyrrolidine dithiocarbamic acid	57-84	matrix metallopeptidase 9	Homo sapiens	120-125
17673717-9	2007	Minocycline and pyrrolidine dithiocarbamate administration suppressed vascular endothelial growth factor-induced MMP-9 activity (n=6, P=0.003 and P=0.01, respectively) and the associated increases in hemoglobin levels (n=5-6, P=0.001 and P=0.02, respectively).	pyrrolidine dithiocarbamic acid	16-43	vascular endothelial growth factor A	Homo sapiens	70-104
17673717-9	2007	Minocycline and pyrrolidine dithiocarbamate administration suppressed vascular endothelial growth factor-induced MMP-9 activity (n=6, P=0.003 and P=0.01, respectively) and the associated increases in hemoglobin levels (n=5-6, P=0.001 and P=0.02, respectively).	pyrrolidine dithiocarbamic acid	16-43	matrix metallopeptidase 9	Homo sapiens	113-118
17645304-9	2007	MEPE could also trigger time-dependently extracellular signal-regulated kinase (ERK)1/2 phosphorylation in VSMCs, which was attenuated by antioxidants N-acetylcysteine (NAC) and pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	178-204	mitogen activated protein kinase 3	Rattus norvegicus	41-87
17645304-9	2007	MEPE could also trigger time-dependently extracellular signal-regulated kinase (ERK)1/2 phosphorylation in VSMCs, which was attenuated by antioxidants N-acetylcysteine (NAC) and pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	206-210	mitogen activated protein kinase 3	Rattus norvegicus	41-87
17608808-4	2007	The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors).	pyrrolidine dithiocarbamic acid	198-225	interleukin 6	Homo sapiens	37-50
17608808-4	2007	The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors).	pyrrolidine dithiocarbamic acid	198-225	nuclear factor kappa B subunit 1	Homo sapiens	77-86
17608808-4	2007	The release of interleukin-1beta and interleukin-6, nuclear translocation of NF-kappaB and its DNA binding activity in the SEC1-stimulated PBMC were time-dependent and were completely eliminated by pyrrolidine dithiocarbamate or SN-50 (NF-kappaB inhibitors).	pyrrolidine dithiocarbamic acid	198-225	nuclear factor kappa B subunit 1	Homo sapiens	236-245
17322284-5	2007	ROS was significantly inhibited by preincubation of SCLC cells with pyrrolidine dithiocarbamate (PDTC, 100 microM) and/or SU11274 (small molecule c-Met tyrosine kinase inhibitor, 2 microM) for 3 h. PDTC and SU11274 also abrogated the HGF proliferative signal and cell motility in a cooperative fashion.	pyrrolidine dithiocarbamic acid	68-95	hepatocyte growth factor	Homo sapiens	234-237
17611319-9	2007	Such effects of ADMA on the level of TGF-beta(1) mRNA could be markedly attenuated by pretreatment with antioxidant pyrrolidine dithiocarbamate (25micromol/L).	pyrrolidine dithiocarbamic acid	116-143	transforming growth factor, beta 1	Rattus norvegicus	37-48
17704549-10	2007	The increased production of NO from rIFN-gamma plus KJE-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	127-154	interferon gamma	Rattus norvegicus	36-46
17704549-10	2007	The increased production of NO from rIFN-gamma plus KJE-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	127-154	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-194
17704549-10	2007	The increased production of NO from rIFN-gamma plus KJE-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	127-154	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-205
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	interleukin 1 beta	Homo sapiens	18-26
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	interleukin 6	Homo sapiens	28-32
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	tumor necrosis factor	Homo sapiens	53-62
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor kappa B subunit 1	Homo sapiens	140-149
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	interleukin 1 beta	Homo sapiens	18-26
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	interleukin 6	Homo sapiens	28-32
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	tumor necrosis factor	Homo sapiens	53-62
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	nuclear factor kappa B subunit 1	Homo sapiens	140-149
17336340-7	2007	As well, hemin-induced IL-8 secretion was significantly reduced in a concentration-dependent fashion following pyrrolidine dithiocarbamate exposure, suggesting that induction occurred via an oxidant-sensitive mechanism.	pyrrolidine dithiocarbamic acid	111-138	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
17135302-6	2007	In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	13-22
17409235-0	2007	Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.	pyrrolidine dithiocarbamic acid	0-27	thymoma viral proto-oncogene 1	Mus musculus	38-41
17409235-0	2007	Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.	pyrrolidine dithiocarbamic acid	0-27	presenilin 1	Mus musculus	79-82
17135302-6	2007	In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta.	pyrrolidine dithiocarbamic acid	37-64	ATP binding cassette subfamily A member 1	Homo sapiens	104-109
17135302-6	2007	In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta.	pyrrolidine dithiocarbamic acid	37-64	interleukin 1 beta	Homo sapiens	113-121
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	pyrrolidine dithiocarbamic acid	22-49	nuclear factor kappa B subunit 1	Homo sapiens	0-9
17360948-5	2007	The light chain-mediated effect on MCP-1 production was inhibited by co-incubation with 1,3-dimethyl-2-thiourea, which also inhibited lactate dehydrogenase release, and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	172-199	C-C motif chemokine ligand 2	Homo sapiens	35-40
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	pyrrolidine dithiocarbamic acid	22-49	interleukin 1 beta	Homo sapiens	78-86
17320758-8	2007	Interestingly, pretreatment with pyrrolidine dithiocarbamate (PDTC, 25 microM/10 min), an NF-kappaB inhibitor, blocked the H(2)O(2)-induced nuclear translocation of NF-kappaB, increase in PKC activity, and GRK 2 translocation and hyperphosphorylation of D1 receptors in the proximal tubular membranes.	pyrrolidine dithiocarbamic acid	33-60	G protein-coupled receptor kinase 2	Rattus norvegicus	206-211
17320758-8	2007	Interestingly, pretreatment with pyrrolidine dithiocarbamate (PDTC, 25 microM/10 min), an NF-kappaB inhibitor, blocked the H(2)O(2)-induced nuclear translocation of NF-kappaB, increase in PKC activity, and GRK 2 translocation and hyperphosphorylation of D1 receptors in the proximal tubular membranes.	pyrrolidine dithiocarbamic acid	62-66	G protein-coupled receptor kinase 2	Rattus norvegicus	206-211
19071515-3	2007	Effective formation of ammonium pyrrolidine dithiocarbamate complexes and subsequently retention in PCTFE packed column, was achieved in pH range 1.0-1.6 and 1.5-3.2 for Cr(VI) and Pb(II) ions, respectively.	pyrrolidine dithiocarbamic acid	23-59	submaxillary gland androgen regulated protein 3B	Homo sapiens	181-187
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	84-111	tumor necrosis factor	Homo sapiens	182-209
17020896-4	2007	METHODS: HLE B-3 cells were stimulated by various concentrations of H(2)O(2) in the presence or absence of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	136-140	nuclear factor kappa B subunit 1	Homo sapiens	165-174
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	84-111	tumor necrosis factor	Homo sapiens	211-220
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	84-111	coagulation factor III, tissue factor	Homo sapiens	230-243
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	84-111	coagulation factor III, tissue factor	Homo sapiens	245-247
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	113-117	tumor necrosis factor	Homo sapiens	182-209
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	113-117	tumor necrosis factor	Homo sapiens	211-220
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	113-117	coagulation factor III, tissue factor	Homo sapiens	230-243
17266944-1	2007	OBJECTIVES: The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs).	pyrrolidine dithiocarbamic acid	113-117	coagulation factor III, tissue factor	Homo sapiens	245-247
17174578-5	2007	Treatment with another antioxidant, pyrrolidine dithiocarbamate, also caused the attenuation of TER119 expression.	pyrrolidine dithiocarbamic acid	36-63	lymphocyte antigen 76	Mus musculus	96-102
17242297-7	2007	Both pyrrolidine dithiocarbamate and eplerenone reduced (P<0.05) p105 mRNA and increased IkappaB mRNA in PVN.	pyrrolidine dithiocarbamic acid	5-32	nucleoporin 107	Rattus norvegicus	68-72
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	46-73	nuclear factor kappa B subunit 1	Homo sapiens	85-94
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	46-73	alkaline phosphatase, intestinal	Homo sapiens	146-149
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	75-79	tumor necrosis factor	Homo sapiens	32-41
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	75-79	nuclear factor kappa B subunit 1	Homo sapiens	85-94
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	75-79	tumor necrosis factor	Homo sapiens	32-35
17253597-6	2007	Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, prevented TNF-mediated up-regulation of IAP gene expression levels.	pyrrolidine dithiocarbamic acid	75-79	alkaline phosphatase, intestinal	Homo sapiens	146-149
17429166-8	2007	Pretreatment with PDTC (120 mg/kg, 30 min before PFIB exposure) resulted in a significant inhibitive effect on the activation of NF-kappaB (0.5 h post PFIB exposure) and expression of IL-1beta and IL-8 (1 h post PFIB exposure).	pyrrolidine dithiocarbamic acid	18-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
17429166-8	2007	Pretreatment with PDTC (120 mg/kg, 30 min before PFIB exposure) resulted in a significant inhibitive effect on the activation of NF-kappaB (0.5 h post PFIB exposure) and expression of IL-1beta and IL-8 (1 h post PFIB exposure).	pyrrolidine dithiocarbamic acid	18-22	interleukin 1 beta	Mus musculus	184-192
17429166-8	2007	Pretreatment with PDTC (120 mg/kg, 30 min before PFIB exposure) resulted in a significant inhibitive effect on the activation of NF-kappaB (0.5 h post PFIB exposure) and expression of IL-1beta and IL-8 (1 h post PFIB exposure).	pyrrolidine dithiocarbamic acid	18-22	chemokine (C-X-C motif) ligand 15	Mus musculus	197-201
17173973-7	2007	In addition, treatment with a NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could only weakly suppress the up-regulation of SR-A by the combination.	pyrrolidine dithiocarbamic acid	50-77	macrophage scavenger receptor 1	Mus musculus	133-137
17173973-7	2007	In addition, treatment with a NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could only weakly suppress the up-regulation of SR-A by the combination.	pyrrolidine dithiocarbamic acid	79-83	macrophage scavenger receptor 1	Mus musculus	133-137
17196658-9	2007	Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	141-168	nuclear factor kappa B subunit 1	Homo sapiens	27-53
17196658-9	2007	Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	170-174	nuclear factor kappa B subunit 1	Homo sapiens	27-53
17196658-9	2007	Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	170-174	interleukin 9	Homo sapiens	86-89
17196658-9	2007	Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	170-174	interleukin 12A	Homo sapiens	94-97
17334236-6	2007	TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	202-229	tumor necrosis factor	Homo sapiens	0-9
17334236-6	2007	TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	202-229	phosphatase and tensin homolog	Homo sapiens	20-24
17334236-6	2007	TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose-dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	202-229	RELA proto-oncogene, NF-kB subunit	Homo sapiens	152-155
17189830-6	2007	In vivo, the antioxidant pyrrolidine dithiocarbamate suppressed the expression of NF-kappaB-regulated genes such as IkappaB and inducible nitric oxide synthase.	pyrrolidine dithiocarbamic acid	25-52	nuclear factor kappa B subunit 1	Homo sapiens	82-91
16924672-7	2007	The addition of the antioxidant pyrrolidine dithiocarbamate (PDTC) significantly inhibited Dol-P-induced ROS generation and activation of caspase-3.	pyrrolidine dithiocarbamic acid	32-59	caspase 3	Homo sapiens	138-147
16924672-7	2007	The addition of the antioxidant pyrrolidine dithiocarbamate (PDTC) significantly inhibited Dol-P-induced ROS generation and activation of caspase-3.	pyrrolidine dithiocarbamic acid	61-65	caspase 3	Homo sapiens	138-147
16985215-7	2007	Moreover the uric acid-induced inhibition of [(3)H]thymidine incorporation was also blocked by two NF-kappaB inhibitors, pyrrolidine dithiocarbamate and SN 50.	pyrrolidine dithiocarbamic acid	121-148	nuclear factor kappa B subunit 1	Homo sapiens	99-108
17386086-11	2007	Similarly, inhibitors of NF-kappaB signaling (pyrrolidine dithiocarbamate, MG-132, and SN-50) abolished the suppressive effect of IL-1.	pyrrolidine dithiocarbamic acid	46-73	interleukin 1 beta	Homo sapiens	130-134
17202436-2	2007	This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice.	pyrrolidine dithiocarbamic acid	45-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-104
17849265-6	2007	In addition, the release of IL-6 was also inhibited by either pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which are potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	62-89	interleukin 6	Homo sapiens	28-32
17849265-6	2007	In addition, the release of IL-6 was also inhibited by either pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which are potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	91-95	interleukin 6	Homo sapiens	28-32
17202436-2	2007	This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice.	pyrrolidine dithiocarbamic acid	74-78	interleukin 6	Mus musculus	109-127
17202436-2	2007	This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice.	pyrrolidine dithiocarbamic acid	45-72	interleukin 6	Mus musculus	109-127
17202436-2	2007	This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice.	pyrrolidine dithiocarbamic acid	74-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-104
18204303-10	2007	Pyrrolidine dithiocarbamate also inhibited the induction of caspase-10 mRNA expression and caspase-3 activation.	pyrrolidine dithiocarbamic acid	0-27	caspase 10	Homo sapiens	60-70
18204303-10	2007	Pyrrolidine dithiocarbamate also inhibited the induction of caspase-10 mRNA expression and caspase-3 activation.	pyrrolidine dithiocarbamic acid	0-27	caspase 3	Homo sapiens	91-100
16814471-10	2006	When 12 PBH was chosen as the time point for in vitro intervention with the application of specific NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), PKC inhibitor H-7 and PNS, both TNF-alpha mRNA expression and NF-kappaB activity decreased significantly.	pyrrolidine dithiocarbamic acid	120-147	tumor necrosis factor	Mus musculus	188-197
17008387-2	2007	Because inflammation and oxidative damage are also hallmarks of amyotrophic lateral sclerosis (ALS), we studied the effect of oral PDTC treatment on G93A-superoxide dismutase 1 (SOD1) transgenic (TG) rat model of human ALS and observed that PDTC treatment significantly decreases the survival.	pyrrolidine dithiocarbamic acid	131-135	superoxide dismutase 1	Rattus norvegicus	153-176
17008387-2	2007	Because inflammation and oxidative damage are also hallmarks of amyotrophic lateral sclerosis (ALS), we studied the effect of oral PDTC treatment on G93A-superoxide dismutase 1 (SOD1) transgenic (TG) rat model of human ALS and observed that PDTC treatment significantly decreases the survival.	pyrrolidine dithiocarbamic acid	131-135	superoxide dismutase 1	Rattus norvegicus	178-182
17008387-5	2007	The copper concentration in the spinal cord was increased after PDTC treatment both in G93A-SOD1 TG and wild-type rats, suggesting that increased copper may enhance the neurotoxicity of mutant SOD1.	pyrrolidine dithiocarbamic acid	64-68	superoxide dismutase 1	Rattus norvegicus	92-96
17008387-5	2007	The copper concentration in the spinal cord was increased after PDTC treatment both in G93A-SOD1 TG and wild-type rats, suggesting that increased copper may enhance the neurotoxicity of mutant SOD1.	pyrrolidine dithiocarbamic acid	64-68	superoxide dismutase 1	Rattus norvegicus	193-197
17008387-9	2007	These results suggest that PDTC acts as an immunoproteasome inhibitor in mutant SOD1 rats and that immunoproteasome may help the nervous system to cope with deleterious effects of SOD1-G93A mutation.	pyrrolidine dithiocarbamic acid	27-31	superoxide dismutase 1	Rattus norvegicus	80-84
17627037-11	2007	The antioxidant pyrrolidine dithiocarbamate inhibited COX-2 protein expression and COX-2 transcriptional activity induced by gp120.	pyrrolidine dithiocarbamic acid	16-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
17627037-11	2007	The antioxidant pyrrolidine dithiocarbamate inhibited COX-2 protein expression and COX-2 transcriptional activity induced by gp120.	pyrrolidine dithiocarbamic acid	16-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
17627037-11	2007	The antioxidant pyrrolidine dithiocarbamate inhibited COX-2 protein expression and COX-2 transcriptional activity induced by gp120.	pyrrolidine dithiocarbamic acid	16-43	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	125-130
17054926-7	2006	Further, a chemical inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), as well as transfection using a dominant negative form of IKKbeta, resulted in profound reduction of the TLR-initiated pro-inflammatory response.	pyrrolidine dithiocarbamic acid	73-77	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
17054926-7	2006	Further, a chemical inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), as well as transfection using a dominant negative form of IKKbeta, resulted in profound reduction of the TLR-initiated pro-inflammatory response.	pyrrolidine dithiocarbamic acid	73-77	inhibitor of kappaB kinase beta	Mus musculus	138-145
16972258-8	2006	Pyrrolidine dithiocarbamate (PDTC), a free-radical scavenger, inhibited 4HPR-induced ROS generation, the expression of its downstream mediator, Gadd153, and apoptosis in the pretreated cells.	pyrrolidine dithiocarbamic acid	0-27	DNA damage inducible transcript 3	Homo sapiens	144-151
16972258-8	2006	Pyrrolidine dithiocarbamate (PDTC), a free-radical scavenger, inhibited 4HPR-induced ROS generation, the expression of its downstream mediator, Gadd153, and apoptosis in the pretreated cells.	pyrrolidine dithiocarbamic acid	29-33	DNA damage inducible transcript 3	Homo sapiens	144-151
16998220-2	2006	This study investigates the effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, on two metastatic human RCC cell lines, ACHN and SN12K1.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	76-85
16998220-2	2006	This study investigates the effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, on two metastatic human RCC cell lines, ACHN and SN12K1.	pyrrolidine dithiocarbamic acid	67-71	nuclear factor kappa B subunit 1	Homo sapiens	76-85
16881871-2	2006	We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion.	pyrrolidine dithiocarbamic acid	30-34	heme oxygenase 1	Homo sapiens	69-73
16881871-2	2006	We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion.	pyrrolidine dithiocarbamic acid	30-34	heme oxygenase 1	Homo sapiens	75-91
16881871-2	2006	We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion.	pyrrolidine dithiocarbamic acid	36-63	heme oxygenase 1	Homo sapiens	69-73
16881871-2	2006	We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion.	pyrrolidine dithiocarbamic acid	36-63	heme oxygenase 1	Homo sapiens	75-91
16705055-7	2006	An antioxidant/NF-kappaB inhibitor (pyrrolidine dithiocarbamate) and an inhibitor of 1kappaB-alpha phosphorylation (Bay 11-7085) also blocked ANG II-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	36-63	angiotensinogen	Rattus norvegicus	142-148
16926159-0	2006	Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	37-50
16926159-0	2006	Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes.	pyrrolidine dithiocarbamic acid	0-27	signal transducer and activator of transcription 3	Homo sapiens	78-83
16926159-2	2006	Although previous studies have demonstrated that pyrrolidine dithiocarbamate (PDTC) exerts protection against inflammatory responses, its role in the regulation of IL-6 receptor signaling remains unclear.	pyrrolidine dithiocarbamic acid	78-82	interleukin 6	Homo sapiens	164-168
16950627-4	2006	Two other Hsp90 inhibitors, 17-allylamino-17-demethoxygeldanamycin (17-AAG) and radicicol, and pyrrolidine dithiocarbamate induced robust expression of Hsp70 and Hsp40 in motor neurons, but at cytotoxic concentrations.	pyrrolidine dithiocarbamic acid	95-122	heat shock protein family A (Hsp70) member 4	Homo sapiens	152-157
16950627-4	2006	Two other Hsp90 inhibitors, 17-allylamino-17-demethoxygeldanamycin (17-AAG) and radicicol, and pyrrolidine dithiocarbamate induced robust expression of Hsp70 and Hsp40 in motor neurons, but at cytotoxic concentrations.	pyrrolidine dithiocarbamic acid	95-122	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	162-167
16705055-7	2006	An antioxidant/NF-kappaB inhibitor (pyrrolidine dithiocarbamate) and an inhibitor of 1kappaB-alpha phosphorylation (Bay 11-7085) also blocked ANG II-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	36-63	C-C motif chemokine ligand 2	Rattus norvegicus	157-162
17172033-4	2006	The effects of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB and of cycloheximide (CHX), a protein synthase inhibitor, on the expression of iNOS and on the activation of NF-kappaB were also investigated in mouse macrophages treated with LAMPs.	pyrrolidine dithiocarbamic acid	15-42	nitric oxide synthase 2, inducible	Mus musculus	156-160
16973825-4	2006	We found that TNF-alpha significantly increased adhesiveness of the monocytic THP-1 cells to HCAECs, an effect that could be inhibited by pretreatment with resveratrol and the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	196-223	tumor necrosis factor	Homo sapiens	14-23
16973825-4	2006	We found that TNF-alpha significantly increased adhesiveness of the monocytic THP-1 cells to HCAECs, an effect that could be inhibited by pretreatment with resveratrol and the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	196-223	nuclear factor kappa B subunit 1	Homo sapiens	176-185
16973825-7	2006	Using a reporter gene assay, we found that, in HCAECs, TNF-alpha significantly increased NF-kappaB activity, which could be inhibited by resveratrol (>50% inhibition at 10(-6) mol/l) and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	190-217	tumor necrosis factor	Homo sapiens	55-64
16973825-7	2006	Using a reporter gene assay, we found that, in HCAECs, TNF-alpha significantly increased NF-kappaB activity, which could be inhibited by resveratrol (>50% inhibition at 10(-6) mol/l) and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	190-217	nuclear factor kappa B subunit 1	Homo sapiens	89-98
17013094-3	2006	Autotaxin induced uPA expression in a dose-dependent manner that was inhibited by pharmacological inhibitors for Gi (pertussis toxin), phosphoinositide 3-kinase (PI3K, LY294002), Akt inhibitor (AktI), proteosome activity and IkappaB phosphorylation (pyrrolidine dithiocarbamate), and by a dominant negative mutant (DN) of Akt.	pyrrolidine dithiocarbamic acid	250-277	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
17013094-3	2006	Autotaxin induced uPA expression in a dose-dependent manner that was inhibited by pharmacological inhibitors for Gi (pertussis toxin), phosphoinositide 3-kinase (PI3K, LY294002), Akt inhibitor (AktI), proteosome activity and IkappaB phosphorylation (pyrrolidine dithiocarbamate), and by a dominant negative mutant (DN) of Akt.	pyrrolidine dithiocarbamic acid	250-277	plasminogen activator, urokinase	Homo sapiens	18-21
17098045-1	2006	PURPOSE: We investigated whether pharmacologically induced up-regulation of heme oxygenase 1 by pyrrolidine dithiocarbamate (PDTC) conferred protection against subsequent ischemia-reperfusion injury (IRI) to the rat liver after temporary vascular occlusion of 70% of the organ.	pyrrolidine dithiocarbamic acid	96-123	heme oxygenase 1	Rattus norvegicus	76-92
17098045-1	2006	PURPOSE: We investigated whether pharmacologically induced up-regulation of heme oxygenase 1 by pyrrolidine dithiocarbamate (PDTC) conferred protection against subsequent ischemia-reperfusion injury (IRI) to the rat liver after temporary vascular occlusion of 70% of the organ.	pyrrolidine dithiocarbamic acid	125-129	heme oxygenase 1	Rattus norvegicus	76-92
16527444-6	2006	Interestingly, pyrrolidine dithiocarbamate (PDTC, for NF-kappaB inhibitor) and N omega-Nitro-L-arginine methylester hydrochloride (L-NAME, for NO inhibitor) effectively stimulated the caspase-3 activation in HCT-116 cells.	pyrrolidine dithiocarbamic acid	15-42	nuclear factor kappa B subunit 1	Homo sapiens	54-63
16527444-6	2006	Interestingly, pyrrolidine dithiocarbamate (PDTC, for NF-kappaB inhibitor) and N omega-Nitro-L-arginine methylester hydrochloride (L-NAME, for NO inhibitor) effectively stimulated the caspase-3 activation in HCT-116 cells.	pyrrolidine dithiocarbamic acid	15-42	caspase 3	Homo sapiens	184-193
16527444-6	2006	Interestingly, pyrrolidine dithiocarbamate (PDTC, for NF-kappaB inhibitor) and N omega-Nitro-L-arginine methylester hydrochloride (L-NAME, for NO inhibitor) effectively stimulated the caspase-3 activation in HCT-116 cells.	pyrrolidine dithiocarbamic acid	44-48	nuclear factor kappa B subunit 1	Homo sapiens	54-63
17172033-4	2006	The effects of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB and of cycloheximide (CHX), a protein synthase inhibitor, on the expression of iNOS and on the activation of NF-kappaB were also investigated in mouse macrophages treated with LAMPs.	pyrrolidine dithiocarbamic acid	44-48	nitric oxide synthase 2, inducible	Mus musculus	156-160
17217823-0	2006	[Nuclear factor-kappaB expression in peripheral blood polymorphonuclear leukocytes of patients with acute pancreatitis and the preventive effectiveness of pyrrolidine dithiocarbamate on NF-kappaB in vitro].	pyrrolidine dithiocarbamic acid	155-182	nuclear factor kappa B subunit 1	Homo sapiens	186-195
17009971-1	2006	The objective of this study was to determine whether paclitaxel and a strong antioxidant, pyrrolidinedithiocarbamate (PDTC), can affect the activation of nuclear factor-kappa B (NF-kappaB) in SKOV-3 human ovarian cancer cell line and the effect of these two agents on the growth and apoptosis of the cancer cells.	pyrrolidine dithiocarbamic acid	90-116	nuclear factor kappa B subunit 1	Homo sapiens	154-176
16899768-9	2006	A role of NF-kappaB as the mediator of the H2O2 induction of VEGFR2 mRNA expression was supported by inhibition by the ROS scavenger pyrrolidine dithiocarbamate and by the blocking effect of transfected IkappaBalpha.	pyrrolidine dithiocarbamic acid	133-160	nuclear factor kappa B subunit 1	Homo sapiens	10-19
16899768-9	2006	A role of NF-kappaB as the mediator of the H2O2 induction of VEGFR2 mRNA expression was supported by inhibition by the ROS scavenger pyrrolidine dithiocarbamate and by the blocking effect of transfected IkappaBalpha.	pyrrolidine dithiocarbamic acid	133-160	kinase insert domain receptor	Homo sapiens	61-67
16904205-0	2006	Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	129-156	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-36
16904205-0	2006	Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	129-156	mitogen-activated protein kinase 1	Homo sapiens	63-66
16904205-1	2006	We present evidence that pyrrolidine dithiocarbamate (PDTC) inhibits growth of p53-negative pancreatic adenocarcinoma cell lines via cell cycle arrest in the S-phase, while it has no effect on primary fibroblast proliferation.	pyrrolidine dithiocarbamic acid	25-52	tumor protein p53	Homo sapiens	79-82
16904205-1	2006	We present evidence that pyrrolidine dithiocarbamate (PDTC) inhibits growth of p53-negative pancreatic adenocarcinoma cell lines via cell cycle arrest in the S-phase, while it has no effect on primary fibroblast proliferation.	pyrrolidine dithiocarbamic acid	54-58	tumor protein p53	Homo sapiens	79-82
17009971-1	2006	The objective of this study was to determine whether paclitaxel and a strong antioxidant, pyrrolidinedithiocarbamate (PDTC), can affect the activation of nuclear factor-kappa B (NF-kappaB) in SKOV-3 human ovarian cancer cell line and the effect of these two agents on the growth and apoptosis of the cancer cells.	pyrrolidine dithiocarbamic acid	90-116	nuclear factor kappa B subunit 1	Homo sapiens	178-187
17009971-1	2006	The objective of this study was to determine whether paclitaxel and a strong antioxidant, pyrrolidinedithiocarbamate (PDTC), can affect the activation of nuclear factor-kappa B (NF-kappaB) in SKOV-3 human ovarian cancer cell line and the effect of these two agents on the growth and apoptosis of the cancer cells.	pyrrolidine dithiocarbamic acid	118-122	nuclear factor kappa B subunit 1	Homo sapiens	154-176
17009971-1	2006	The objective of this study was to determine whether paclitaxel and a strong antioxidant, pyrrolidinedithiocarbamate (PDTC), can affect the activation of nuclear factor-kappa B (NF-kappaB) in SKOV-3 human ovarian cancer cell line and the effect of these two agents on the growth and apoptosis of the cancer cells.	pyrrolidine dithiocarbamic acid	118-122	nuclear factor kappa B subunit 1	Homo sapiens	178-187
16871588-7	2006	Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin-induced H(2)O(2), NO, TNF-alpha, and IL-6 synthesis.	pyrrolidine dithiocarbamic acid	59-86	mitogen activated protein kinase 14	Rattus norvegicus	14-17
16871588-7	2006	Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin-induced H(2)O(2), NO, TNF-alpha, and IL-6 synthesis.	pyrrolidine dithiocarbamic acid	59-86	tumor necrosis factor	Rattus norvegicus	142-151
16871588-7	2006	Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin-induced H(2)O(2), NO, TNF-alpha, and IL-6 synthesis.	pyrrolidine dithiocarbamic acid	59-86	interleukin 6	Rattus norvegicus	157-161
16804527-0	2006	Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut.	pyrrolidine dithiocarbamic acid	93-119	transformation related protein 53, pseudogene	Mus musculus	25-28
16804527-8	2006	Pyrrolidinedithiocarbamate and NAC antagonised p53-dependent but potentiated p53-independent apoptotic activity.	pyrrolidine dithiocarbamic acid	0-26	transformation related protein 53, pseudogene	Mus musculus	47-50
16804527-8	2006	Pyrrolidinedithiocarbamate and NAC antagonised p53-dependent but potentiated p53-independent apoptotic activity.	pyrrolidine dithiocarbamic acid	0-26	transformation related protein 53, pseudogene	Mus musculus	77-80
16815050-9	2006	Pyrrolidine dithiocarbamate (PDTC) suppressed Hcy-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by Hcy.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Rattus norvegicus	58-62
16580131-3	2006	LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not.	pyrrolidine dithiocarbamic acid	121-157	interleukin 1 beta	Rattus norvegicus	14-22
16580131-3	2006	LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not.	pyrrolidine dithiocarbamic acid	159-163	interleukin 1 beta	Rattus norvegicus	14-22
16815050-9	2006	Pyrrolidine dithiocarbamate (PDTC) suppressed Hcy-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by Hcy.	pyrrolidine dithiocarbamic acid	29-33	interleukin 6	Rattus norvegicus	58-62
16402387-7	2006	Treatment of PC-3 high invasive and RhoA Q63E cells with sodium salicylate or lactacystin inhibited NF-kappaB and invasion, while pyrrolidine dithiocarbamate (PDTC) treatment of PC-3 high invasive cells inhibited NF-kappaB only.	pyrrolidine dithiocarbamic acid	130-157	nuclear factor kappa B subunit 1	Homo sapiens	213-222
16402387-7	2006	Treatment of PC-3 high invasive and RhoA Q63E cells with sodium salicylate or lactacystin inhibited NF-kappaB and invasion, while pyrrolidine dithiocarbamate (PDTC) treatment of PC-3 high invasive cells inhibited NF-kappaB only.	pyrrolidine dithiocarbamic acid	159-163	nuclear factor kappa B subunit 1	Homo sapiens	213-222
16687627-6	2006	Inhibition of these pathways with pyrrolidine dithiocarbamate, PD 98059, and fludarabine, respectively, attenuated GA-induced IL-8 secretion.	pyrrolidine dithiocarbamic acid	34-61	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16624564-5	2006	Pyrrolidine dithiocarbamate (PDTC) given intraperitoneally 30 min before Abeta injection and daily for 7 days postsurgery significantly prevented Abeta-induced neuropathological and neuroinflammatory responses, as well as the learning and spatial memory deficits.	pyrrolidine dithiocarbamic acid	0-27	amyloid beta precursor protein	Rattus norvegicus	73-78
16624564-5	2006	Pyrrolidine dithiocarbamate (PDTC) given intraperitoneally 30 min before Abeta injection and daily for 7 days postsurgery significantly prevented Abeta-induced neuropathological and neuroinflammatory responses, as well as the learning and spatial memory deficits.	pyrrolidine dithiocarbamic acid	0-27	amyloid beta precursor protein	Rattus norvegicus	146-151
16624564-5	2006	Pyrrolidine dithiocarbamate (PDTC) given intraperitoneally 30 min before Abeta injection and daily for 7 days postsurgery significantly prevented Abeta-induced neuropathological and neuroinflammatory responses, as well as the learning and spatial memory deficits.	pyrrolidine dithiocarbamic acid	29-33	amyloid beta precursor protein	Rattus norvegicus	73-78
16624564-5	2006	Pyrrolidine dithiocarbamate (PDTC) given intraperitoneally 30 min before Abeta injection and daily for 7 days postsurgery significantly prevented Abeta-induced neuropathological and neuroinflammatory responses, as well as the learning and spatial memory deficits.	pyrrolidine dithiocarbamic acid	29-33	amyloid beta precursor protein	Rattus norvegicus	146-151
16756349-0	2006	Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells.	pyrrolidine dithiocarbamic acid	0-27	AKT serine/threonine kinase 1	Homo sapiens	109-112
16756349-0	2006	Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells.	pyrrolidine dithiocarbamic acid	0-27	caspase 9	Homo sapiens	117-126
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 beta	Homo sapiens	42-50
16771850-6	2006	TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	91-118	tumor necrosis factor	Rattus norvegicus	0-3
16771850-6	2006	TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	91-118	C-X-C motif chemokine ligand 2	Rattus norvegicus	22-27
16771850-6	2006	TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	120-124	tumor necrosis factor	Rattus norvegicus	0-3
16771850-6	2006	TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate (PDTC) and helenalin, two potent NF-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	120-124	C-X-C motif chemokine ligand 2	Rattus norvegicus	22-27
16728240-4	2006	On the other hand, ALP activity was significantly increased on HDP cells treated with Ammonium Pyrrolidinedithiocarbamate (PDTC, NF- kappaB inhibitor) groups and combined supplementation of TNF-alpha and PDTC groups.	pyrrolidine dithiocarbamic acid	86-121	alkaline phosphatase, placental	Homo sapiens	19-22
16815071-6	2006	TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003).	pyrrolidine dithiocarbamic acid	264-291	REL proto-oncogene, NF-kB subunit	Homo sapiens	53-58
16815071-6	2006	TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003).	pyrrolidine dithiocarbamic acid	264-291	RELA proto-oncogene, NF-kB subunit	Homo sapiens	40-43
16815071-6	2006	TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003).	pyrrolidine dithiocarbamic acid	264-291	nuclear factor kappa B subunit 1	Homo sapiens	101-110
16815071-6	2006	TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003).	pyrrolidine dithiocarbamic acid	264-291	NFKB inhibitor alpha	Homo sapiens	119-131
16729259-15	2006	Both, the pharmacological blockade of NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC) or Bay11-7082 and genetic blockade by expression of a transdominant-negative super-repressor IkappaB-AA1 led to decreased aggregation.	pyrrolidine dithiocarbamic acid	59-86	nuclear factor kappa B subunit 1	Homo sapiens	38-47
16565442-6	2006	Mechanistically, the NF-kappaB activity and Bcl-2 expression were enhanced in the hearts, and a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, abolished the Bcl-2 induction as well as the infarct-limiting effect.	pyrrolidine dithiocarbamic acid	117-144	BCL2, apoptosis regulator	Rattus norvegicus	44-49
16678015-0	2006	Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.	pyrrolidine dithiocarbamic acid	12-39	AKT serine/threonine kinase 1	Homo sapiens	50-53
16678015-1	2006	Pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of transcription factor nuclear factor kappa-B (NF-kappaB), has been reported to reduce inflammation and apoptosis.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	89-111
16678015-1	2006	Pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of transcription factor nuclear factor kappa-B (NF-kappaB), has been reported to reduce inflammation and apoptosis.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	113-122
16678015-1	2006	Pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of transcription factor nuclear factor kappa-B (NF-kappaB), has been reported to reduce inflammation and apoptosis.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	89-111
16678015-1	2006	Pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of transcription factor nuclear factor kappa-B (NF-kappaB), has been reported to reduce inflammation and apoptosis.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	113-122
16687076-5	2006	The expression changes of c-met and matrix metalloproteinase-9 (MMP-9) in SKOV3 cells before and after treatment with HGF and nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) were measured by real-time reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and flow cytometry.	pyrrolidine dithiocarbamic acid	170-197	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	26-31
16687076-5	2006	The expression changes of c-met and matrix metalloproteinase-9 (MMP-9) in SKOV3 cells before and after treatment with HGF and nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) were measured by real-time reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and flow cytometry.	pyrrolidine dithiocarbamic acid	170-197	nuclear factor kappa B subunit 1	Homo sapiens	141-147
16687076-5	2006	The expression changes of c-met and matrix metalloproteinase-9 (MMP-9) in SKOV3 cells before and after treatment with HGF and nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) were measured by real-time reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and flow cytometry.	pyrrolidine dithiocarbamic acid	170-197	nuclear factor kappa B subunit 1	Homo sapiens	149-158
16565442-6	2006	Mechanistically, the NF-kappaB activity and Bcl-2 expression were enhanced in the hearts, and a NF-kappaB inhibitor, pyrrolidine dithiocarbamate, abolished the Bcl-2 induction as well as the infarct-limiting effect.	pyrrolidine dithiocarbamic acid	117-144	BCL2, apoptosis regulator	Rattus norvegicus	160-165
16427608-4	2006	All of these effects were prevented by co-incubation with pyrrolidinedithiocarbamate, an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	58-84	nuclear factor kappa B subunit 1	Homo sapiens	89-98
16772089-8	2006	The expression of IkappaBalpha in THP-1 incubated with burn sera was significantly decreased than those incubated with control sera (1211 +/- 115 vs 2658 +/- 318, P < 0.05), which were abolished by pretreatment with PDTC but not SB203580.	pyrrolidine dithiocarbamic acid	219-223	NFKB inhibitor alpha	Homo sapiens	18-30
16772089-8	2006	The expression of IkappaBalpha in THP-1 incubated with burn sera was significantly decreased than those incubated with control sera (1211 +/- 115 vs 2658 +/- 318, P < 0.05), which were abolished by pretreatment with PDTC but not SB203580.	pyrrolidine dithiocarbamic acid	219-223	GLI family zinc finger 2	Homo sapiens	34-39
16772089-9	2006	Burn sera also leaded to an increased activity of NF-kappaB in THP-1 (1636 +/- 170 vs 317 +/- 32, P < 0.05), which were abolished by pretreatment with PDTC but not SB203580.	pyrrolidine dithiocarbamic acid	154-158	GLI family zinc finger 2	Homo sapiens	63-68
15970429-4	2006	In contrast, apoptosis was markedly reduced by NF-kappaB inhibitor (pyrrolidine dithiocarbamate, PDTC), NF-kappaB antisense oligonucleotide, NO donor (sodium nitroprusside, SNP), and overexpression of Akt.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor kappa B subunit 1	Homo sapiens	47-56
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	120-145
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	NFKB inhibitor alpha	Homo sapiens	162-171
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	X-linked Kx blood group	Homo sapiens	251-254
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	88-92	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	120-145
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	88-92	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	147-156
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	88-92	NFKB inhibitor alpha	Homo sapiens	162-171
16490171-1	2006	AIM: To study the effects of N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	88-92	X-linked Kx blood group	Homo sapiens	251-254
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	nuclear factor kappa B subunit 1	Homo sapiens	4-13
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	interleukin 1 beta	Homo sapiens	59-67
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	hyaluronan synthase 1	Homo sapiens	76-97
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	hyaluronan synthase 1	Homo sapiens	99-103
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	nuclear factor kappa B subunit 1	Homo sapiens	137-146
16723203-0	2006	The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.	pyrrolidine dithiocarbamic acid	24-51	hyaluronan synthase 1	Homo sapiens	170-174
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	42-50
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	0-27	hyaluronan synthase 1	Homo sapiens	59-63
16723203-6	2006	Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely.	pyrrolidine dithiocarbamic acid	29-33	hyaluronan synthase 1	Homo sapiens	59-63
16520234-8	2006	The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant.	pyrrolidine dithiocarbamic acid	238-265	tumor necrosis factor	Homo sapiens	67-94
16410003-4	2006	We investigated the effects of NF-kappaB blocking by pyrrolidine dithiocarbamate (PDTC), a well-known NF-kappaB inhibitor, on dystrophic process in mdx mice.	pyrrolidine dithiocarbamic acid	53-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-40
16410003-4	2006	We investigated the effects of NF-kappaB blocking by pyrrolidine dithiocarbamate (PDTC), a well-known NF-kappaB inhibitor, on dystrophic process in mdx mice.	pyrrolidine dithiocarbamic acid	53-80	dystrophin, muscular dystrophy	Mus musculus	148-151
16410003-4	2006	We investigated the effects of NF-kappaB blocking by pyrrolidine dithiocarbamate (PDTC), a well-known NF-kappaB inhibitor, on dystrophic process in mdx mice.	pyrrolidine dithiocarbamic acid	82-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-40
16410003-4	2006	We investigated the effects of NF-kappaB blocking by pyrrolidine dithiocarbamate (PDTC), a well-known NF-kappaB inhibitor, on dystrophic process in mdx mice.	pyrrolidine dithiocarbamic acid	82-86	dystrophin, muscular dystrophy	Mus musculus	148-151
16410003-5	2006	Five-week-old mdx and wild-type mice received three times a week for 5 weeks either PDTC (50 mg/kg) or its vehicle.	pyrrolidine dithiocarbamic acid	84-88	dystrophin, muscular dystrophy	Mus musculus	14-17
16520234-8	2006	The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant.	pyrrolidine dithiocarbamic acid	238-265	tumor necrosis factor	Homo sapiens	96-105
16520234-8	2006	The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant.	pyrrolidine dithiocarbamic acid	238-265	nuclear factor kappa B subunit 1	Homo sapiens	293-302
16520234-8	2006	The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant.	pyrrolidine dithiocarbamic acid	267-271	tumor necrosis factor	Homo sapiens	67-94
16520234-8	2006	The long-term exposure to oxidized LDL also significantly enhanced tumor necrosis factor-alpha (TNF-alpha)-stimulated ROS production and endothelial adhesiveness of MMCs, which could be completely abolished by the short-term existence of pyrrolidine dithiocarbamate (PDTC), an antioxidant and NF-kappaB blocker and by long-term coincubation with N-acetylcysteine, a nonspecific antioxidant.	pyrrolidine dithiocarbamic acid	267-271	tumor necrosis factor	Homo sapiens	96-105
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	48-84	nuclear factor kappa B subunit 1	Homo sapiens	29-37
16237731-4	2006	The elevation of Cdk2 activity correlates with the increase of UV-induced apoptosis, which can be suppressed by small-molecule Cdk2 inhibitors such as roscovitine and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	167-194	cyclin-dependent kinase 2	Cricetulus griseus	17-21
16237731-4	2006	The elevation of Cdk2 activity correlates with the increase of UV-induced apoptosis, which can be suppressed by small-molecule Cdk2 inhibitors such as roscovitine and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	167-194	cyclin-dependent kinase 2	Cricetulus griseus	127-131
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	48-84	tumor necrosis factor	Homo sapiens	158-166
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	48-84	nuclear factor kappa B subunit 1	Homo sapiens	247-255
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	86-90	nuclear factor kappa B subunit 1	Homo sapiens	29-37
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	86-90	mitogen-activated protein kinase 14	Homo sapiens	128-135
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	86-90	tumor necrosis factor	Homo sapiens	158-166
16457791-8	2006	On the other hand, the other NFkappaB inhibitor ammonium pyrrolidine dithiocarbamate (APDC) neither prevented the activation of p38MAPK and JNK nor inhibited TNFalpha induction in LPS-stimulated microglia, although it was confirmed to serve as an NFkappaB inhibitor.	pyrrolidine dithiocarbamic acid	86-90	nuclear factor kappa B subunit 1	Homo sapiens	247-255
16850757-1	2006	To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on the proliferation and PCNA (proliferating cell nuclear antigen) expression of cultured human retinal pigment epithelium cells, human retinal pigment epithelium cells (RPE) were cultured from normal adults who, died accidentally.	pyrrolidine dithiocarbamic acid	59-63	proliferating cell nuclear antigen	Homo sapiens	90-94
15869794-3	2006	In this study, we demonstrate the upregulation of c-Src in Raw264.7 and peritoneal macrophages (PEMs) by LPS, which is inhibited by PP2 (an inhibitor for Src family kinases), pyrrolidinedithiocarbamate (PDTC; NF-kappaB inhibitor) and LY294002 (PI3K inhibitor).	pyrrolidine dithiocarbamic acid	175-201	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	50-55
15869794-3	2006	In this study, we demonstrate the upregulation of c-Src in Raw264.7 and peritoneal macrophages (PEMs) by LPS, which is inhibited by PP2 (an inhibitor for Src family kinases), pyrrolidinedithiocarbamate (PDTC; NF-kappaB inhibitor) and LY294002 (PI3K inhibitor).	pyrrolidine dithiocarbamic acid	175-201	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	52-55
21186580-4	2006	The changes both of protein and gene expression of heme oxygenase-1 in rats" myocardium, which were induced by injection of LPS or preadministration of the specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate(PDTC), were examined by immunochemistry of reverse transcripted polymerase chain reaction.	pyrrolidine dithiocarbamic acid	189-216	heme oxygenase 1	Rattus norvegicus	51-67
16677502-16	2006	The mRNA expression of ICAM-1 in the intestine of the RAAA group was 0.74 +/- 0.15, significantly higher than that of the sham operation group (0.14 +/- 0.05, P < 0.01) and that of the PDTC group (0.25 +/- 0.08, P < 0.01).	pyrrolidine dithiocarbamic acid	188-192	intercellular adhesion molecule 1	Rattus norvegicus	23-29
16376337-2	2006	This conclusion was supported by the following observations: cisplatin induced IkappaBalpha degradation and NF-kappaB-dependent transcriptional activation prior to cell death; pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB activation, prevented apoptosis; lactacystin, an inhibitor of IkappaBalpha degradation, also prevented apoptosis; and finally, the expression of a super-repressor mutant IkappaBalpha blocked apoptosis.	pyrrolidine dithiocarbamic acid	176-203	NFKB inhibitor alpha	Homo sapiens	308-320
16376337-2	2006	This conclusion was supported by the following observations: cisplatin induced IkappaBalpha degradation and NF-kappaB-dependent transcriptional activation prior to cell death; pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB activation, prevented apoptosis; lactacystin, an inhibitor of IkappaBalpha degradation, also prevented apoptosis; and finally, the expression of a super-repressor mutant IkappaBalpha blocked apoptosis.	pyrrolidine dithiocarbamic acid	176-203	NFKB inhibitor alpha	Homo sapiens	308-320
16223857-6	2006	Palmitate increased nuclear factor (NF)-kappaB activation and incubation of the cells with the NF-kappaB inhibitors pyrrolidine dithiocarbamate and parthenolide partially prevented TNF-alpha expression.	pyrrolidine dithiocarbamic acid	116-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	20-46
16223857-6	2006	Palmitate increased nuclear factor (NF)-kappaB activation and incubation of the cells with the NF-kappaB inhibitors pyrrolidine dithiocarbamate and parthenolide partially prevented TNF-alpha expression.	pyrrolidine dithiocarbamic acid	116-143	tumor necrosis factor	Mus musculus	181-190
16850757-1	2006	To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on the proliferation and PCNA (proliferating cell nuclear antigen) expression of cultured human retinal pigment epithelium cells, human retinal pigment epithelium cells (RPE) were cultured from normal adults who, died accidentally.	pyrrolidine dithiocarbamic acid	59-63	proliferating cell nuclear antigen	Homo sapiens	96-130
16775385-7	2006	Tat-induced COX-2 expression was partially prevented by pyrrolidine dithiocarbamate, a potent antioxidant and an inhibitor of the transcription factor, nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	56-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	103-130	nuclear factor kappa B subunit 1	Homo sapiens	210-219
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	103-130	tumor necrosis factor	Homo sapiens	231-240
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	132-136	nuclear factor kappa B subunit 1	Homo sapiens	0-9
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	132-136	tumor necrosis factor	Homo sapiens	30-39
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	132-136	nuclear factor kappa B subunit 1	Homo sapiens	210-219
17357478-5	2006	NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha (P<0.05).	pyrrolidine dithiocarbamic acid	132-136	tumor necrosis factor	Homo sapiens	231-240
16263754-5	2005	Moreover, inhibitors of MAPK (U0126 and SB203580) significantly reduced the IL-8 production, while the inhibition of NF-kappaB (pyrrolidinedithiocarbamate and retrovirus containing dominant-negative IkappaB alpha plasmid) did not affect the IL-8 expression increased by CpG ODN.	pyrrolidine dithiocarbamic acid	128-154	nuclear factor kappa B subunit 1	Homo sapiens	117-126
16340751-9	2006	Moreover, pretreatment of cells with NF-kappaB inhibitors, pyrrolidine dithiocarbamate or ibuprofen, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	nuclear factor kappa B subunit 1	Homo sapiens	37-46
16340751-9	2006	Moreover, pretreatment of cells with NF-kappaB inhibitors, pyrrolidine dithiocarbamate or ibuprofen, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	epidermal growth factor	Homo sapiens	121-124
16340751-9	2006	Moreover, pretreatment of cells with NF-kappaB inhibitors, pyrrolidine dithiocarbamate or ibuprofen, markedly attenuated EGF-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	59-86	nuclear factor kappa B subunit 1	Homo sapiens	133-142
16298682-4	2005	Rapamycin (2 mg/kg/daily), an inhibitor of the mammalian target of rapamycin, and the antioxidant pyrrolidine dithiocarbamate (PDTC; 120 mg/kg/daily), which can inhibit NFkappaB activation, were administered to caAkt mice at 8 weeks of age for 2 weeks.	pyrrolidine dithiocarbamic acid	98-125	nuclear factor kappa B subunit 1	Homo sapiens	169-177
15936242-7	2005	Pyrrolidinedithiocarbamate, a nuclear factor kappaB inhibitor, dose-dependently suppressed 12-O-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase mRNA.	pyrrolidine dithiocarbamic acid	0-26	aldo-keto reductase family 1 member B	Homo sapiens	148-164
16223606-6	2005	This up-regulation of PHGPx was inhibited by treatment with the anti-oxidants, pyrrolidine dithiocarbamate, and N-acetyl-L-cysteine, and by inhibitors of NFkappaB and Src kinases.	pyrrolidine dithiocarbamic acid	79-106	glutathione peroxidase 4	Homo sapiens	22-27
15996687-8	2005	Furthermore, expression of Hsp70 was increased by treatment with U73122 or pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	75-102	heat shock protein family A (Hsp70) member 4	Homo sapiens	27-32
15996687-8	2005	Furthermore, expression of Hsp70 was increased by treatment with U73122 or pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	104-108	heat shock protein family A (Hsp70) member 4	Homo sapiens	27-32
16262636-6	2005	Intrathecal administration of NF-kappaB inhibitors, pyrrolidinedithiocarbamate (PDTC) and SN50, prior to gp120 partially attenuated gp120-induced allodynia.	pyrrolidine dithiocarbamic acid	52-78	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	132-137
16262636-6	2005	Intrathecal administration of NF-kappaB inhibitors, pyrrolidinedithiocarbamate (PDTC) and SN50, prior to gp120 partially attenuated gp120-induced allodynia.	pyrrolidine dithiocarbamic acid	80-84	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	132-137
16103692-11	2005	The antioxidants pyrrolidine dithiocarbamate and N-acetylcysteine, the flavin protein inhibitor diphenylene iodonium, and the NADP(H) oxidase inhibitor apocynin blocked MMP-1 release, suggesting a redox-sensitive mechanism involving NADP(H) oxidase.	pyrrolidine dithiocarbamic acid	17-44	matrix metallopeptidase 1	Homo sapiens	169-174
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	193-220	interleukin 1 beta	Homo sapiens	20-28
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	193-220	tumor necrosis factor	Homo sapiens	33-42
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	193-220	myelin oligodendrocyte glycoprotein	Homo sapiens	80-83
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	222-226	interleukin 1 beta	Homo sapiens	20-28
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	222-226	tumor necrosis factor	Homo sapiens	33-42
16109311-4	2005	Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	222-226	myelin oligodendrocyte glycoprotein	Homo sapiens	80-83
16174286-13	2005	In addition, prior treatment with pyrrolidine dithiocarbamate (PDTC), which is a NF-KB inhibitor, inhibited aldosterone-induced MCP-1 protein secretion.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Rattus norvegicus	81-86
16174286-13	2005	In addition, prior treatment with pyrrolidine dithiocarbamate (PDTC), which is a NF-KB inhibitor, inhibited aldosterone-induced MCP-1 protein secretion.	pyrrolidine dithiocarbamic acid	34-61	mast cell protease 1-like 1	Rattus norvegicus	128-133
16174286-13	2005	In addition, prior treatment with pyrrolidine dithiocarbamate (PDTC), which is a NF-KB inhibitor, inhibited aldosterone-induced MCP-1 protein secretion.	pyrrolidine dithiocarbamic acid	63-67	nuclear factor kappa B subunit 1	Rattus norvegicus	81-86
16174286-13	2005	In addition, prior treatment with pyrrolidine dithiocarbamate (PDTC), which is a NF-KB inhibitor, inhibited aldosterone-induced MCP-1 protein secretion.	pyrrolidine dithiocarbamic acid	63-67	mast cell protease 1-like 1	Rattus norvegicus	128-133
15805138-6	2005	HIV-1 Tat protein-induced VCAM-1 expression was abolished by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and the p38 MAPK inhibitor SB-203580.	pyrrolidine dithiocarbamic acid	114-118	vascular cell adhesion molecule 1	Homo sapiens	26-32
15936354-7	2005	Prior treatment of the cells with pyrrolidine dithiocarbamate, a potent inhibitor of NF-kappaB activation, or Ac-DEVD-CHO, a specific caspase-3 inhibitor, prevented scopoletin-induced caspase-3 activation, PARP cleavage, and finally DNA fragmentation.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	85-94
16014934-5	2005	The HCV-induced Cox-2 was sensitive to antioxidant (pyrrolidine dithiocarbamate), Ca(2+) chelator (BAPTA-AM), and calpain inhibitor (N-acetyl-Leu-Leu-Met-H).	pyrrolidine dithiocarbamic acid	52-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-21
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	pyrrolidine dithiocarbamic acid	185-212	protein kinase C alpha	Homo sapiens	29-37
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	pyrrolidine dithiocarbamic acid	185-212	protein kinase C alpha	Homo sapiens	29-32
15805138-6	2005	HIV-1 Tat protein-induced VCAM-1 expression was abolished by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and the p38 MAPK inhibitor SB-203580.	pyrrolidine dithiocarbamic acid	85-112	Tat	Human immunodeficiency virus 1	6-9
15805138-6	2005	HIV-1 Tat protein-induced VCAM-1 expression was abolished by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and the p38 MAPK inhibitor SB-203580.	pyrrolidine dithiocarbamic acid	85-112	vascular cell adhesion molecule 1	Homo sapiens	26-32
15805138-6	2005	HIV-1 Tat protein-induced VCAM-1 expression was abolished by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and the p38 MAPK inhibitor SB-203580.	pyrrolidine dithiocarbamic acid	114-118	Tat	Human immunodeficiency virus 1	6-9
16030424-6	2005	Additionally, the increased production of NO from rIFN-gamma plus Solanum nigrum-stimulated cells was almost completely inhibited by pretreatment with 100 micromol/l of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	169-196	interferon gamma	Rattus norvegicus	50-60
15802498-4	2005	Palmitate increased nuclear factor-kappaB activation and coincubation of the cells with palmitate and the nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate prevented both IL-6 expression and secretion.	pyrrolidine dithiocarbamic acid	138-165	interleukin 6	Mus musculus	181-185
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	51-79	interleukin 1 beta	Rattus norvegicus	114-122
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	51-79	interleukin 6	Rattus norvegicus	124-128
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	51-79	tumor necrosis factor	Rattus norvegicus	169-178
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	81-85	interleukin 1 beta	Rattus norvegicus	114-122
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	81-85	interleukin 6	Rattus norvegicus	124-128
15954894-13	2005	Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	81-85	tumor necrosis factor	Rattus norvegicus	169-178
15936354-7	2005	Prior treatment of the cells with pyrrolidine dithiocarbamate, a potent inhibitor of NF-kappaB activation, or Ac-DEVD-CHO, a specific caspase-3 inhibitor, prevented scopoletin-induced caspase-3 activation, PARP cleavage, and finally DNA fragmentation.	pyrrolidine dithiocarbamic acid	34-61	caspase 3	Homo sapiens	184-193
15936354-7	2005	Prior treatment of the cells with pyrrolidine dithiocarbamate, a potent inhibitor of NF-kappaB activation, or Ac-DEVD-CHO, a specific caspase-3 inhibitor, prevented scopoletin-induced caspase-3 activation, PARP cleavage, and finally DNA fragmentation.	pyrrolidine dithiocarbamic acid	34-61	poly(ADP-ribose) polymerase 1	Homo sapiens	206-210
16030495-12	2005	PDTC (200 mg/kg) markedly inhibited the expression of fractalkine mRNA in the iris/ciliary body, and fractalkine protein in aqueous humor.	pyrrolidine dithiocarbamic acid	0-4	C-X3-C motif chemokine ligand 1	Rattus norvegicus	54-65
16030495-12	2005	PDTC (200 mg/kg) markedly inhibited the expression of fractalkine mRNA in the iris/ciliary body, and fractalkine protein in aqueous humor.	pyrrolidine dithiocarbamic acid	0-4	C-X3-C motif chemokine ligand 1	Rattus norvegicus	101-112
15489374-5	2005	IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	112-139	interleukin 1 beta	Homo sapiens	0-8
15888973-8	2005	Notably, treatment with ammonium pyrrolidinedithiocarbamate, an antioxidant and inhibitor of NF-kappaB, inhibited the activation of NF-kappaB in STZ-treated rats and decreased P-selectin in the renal cortical tissue.	pyrrolidine dithiocarbamic acid	24-59	selectin P	Rattus norvegicus	176-186
15897117-6	2005	Pretreatment of the cells with pyrrolidine dithiocarbamate scavenged most of ROS and almost completely blocked TNF-alpha secretion induced by AOPP-BSA.	pyrrolidine dithiocarbamic acid	31-58	tumor necrosis factor	Homo sapiens	111-120
15728783-10	2005	The antioxidant pyrrolidine dithiocarbamate preserved DDAH activity and reduced ADMA accumulation in the same way as the co-incubation with anti-EPO neutralizing antibody.	pyrrolidine dithiocarbamic acid	16-43	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	54-58
15728783-10	2005	The antioxidant pyrrolidine dithiocarbamate preserved DDAH activity and reduced ADMA accumulation in the same way as the co-incubation with anti-EPO neutralizing antibody.	pyrrolidine dithiocarbamic acid	16-43	erythropoietin	Homo sapiens	145-148
15905616-4	2005	The effect of PDTC (pyrrolidine dithiocarbamate), a specific inhibitor of NF-kappaB on the proliferation of gastric cancer cells, was measured by MTT (3-[4,5-dimethythiazol-2-yl]-2,5-diphenyltetrazolium bromide) method.	pyrrolidine dithiocarbamic acid	14-18	nuclear factor kappa B subunit 1	Homo sapiens	74-83
15905616-4	2005	The effect of PDTC (pyrrolidine dithiocarbamate), a specific inhibitor of NF-kappaB on the proliferation of gastric cancer cells, was measured by MTT (3-[4,5-dimethythiazol-2-yl]-2,5-diphenyltetrazolium bromide) method.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor kappa B subunit 1	Homo sapiens	74-83
15907840-3	2005	Pyrrolidine dithiocarbamate, a nuclear factor kappaB (NF-kappaB) inhibitor, repressed the upregulation of taurine uptake and TAUT mRNA expression.	pyrrolidine dithiocarbamic acid	0-27	solute carrier family 6 member 6	Homo sapiens	125-129
15746434-5	2005	The addition of anti-inflammatory agents pyrrolidine dithiocarbamate, pentoxifylline, aspirin, and dexamethasone could completely suppress the expression of IL-8 mRNA in fresh/sensitized lung cancer cell cocultures.	pyrrolidine dithiocarbamic acid	41-68	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15829306-0	2005	Pyrrolidine dithiocarbamate-induced macrophage inflammatory protein-2 gene expression is NF-kappaB-independent but c-Jun-dependent in macrophage cell line RAW 264.7.	pyrrolidine dithiocarbamic acid	0-27	chemokine (C-X-C motif) ligand 2	Mus musculus	36-69
15829306-0	2005	Pyrrolidine dithiocarbamate-induced macrophage inflammatory protein-2 gene expression is NF-kappaB-independent but c-Jun-dependent in macrophage cell line RAW 264.7.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
15829306-0	2005	Pyrrolidine dithiocarbamate-induced macrophage inflammatory protein-2 gene expression is NF-kappaB-independent but c-Jun-dependent in macrophage cell line RAW 264.7.	pyrrolidine dithiocarbamic acid	0-27	jun proto-oncogene	Mus musculus	115-120
15829306-1	2005	Pyrrolidine dithiocarbamate (PDTC) is a stable compound that acts as antioxidant or prooxidant, and is widely used to inhibit the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
15829306-1	2005	Pyrrolidine dithiocarbamate (PDTC) is a stable compound that acts as antioxidant or prooxidant, and is widely used to inhibit the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
15829306-7	2005	Using pathway-specific inhibitors, we found that the SAPK/JNK pathway is clearly associated with PDTC-induced MIP-2 gene expression.	pyrrolidine dithiocarbamic acid	97-101	chemokine (C-X-C motif) ligand 2	Mus musculus	110-115
15851600-3	2005	METHODS AND RESULTS: The proinflammatory cytokine tumor necrosis factor (TNF)-alpha induced NF-kappaBeta activation and elicited significant increases in BMP-2 mRNA and protein in primary coronary arterial endothelial cells and human umbilical vein endothelial cells that were prevented by NF-kappaBeta inhibitors (pyrrolidine dithiocarbamate and SN-50), silencing of p65 (siRNA), or catalase.	pyrrolidine dithiocarbamic acid	315-342	tumor necrosis factor	Homo sapiens	50-83
15851600-3	2005	METHODS AND RESULTS: The proinflammatory cytokine tumor necrosis factor (TNF)-alpha induced NF-kappaBeta activation and elicited significant increases in BMP-2 mRNA and protein in primary coronary arterial endothelial cells and human umbilical vein endothelial cells that were prevented by NF-kappaBeta inhibitors (pyrrolidine dithiocarbamate and SN-50), silencing of p65 (siRNA), or catalase.	pyrrolidine dithiocarbamic acid	315-342	bone morphogenetic protein 2	Homo sapiens	154-159
15592829-10	2005	NF-kappa B inhibitor pyrrolidine dithiocarbamate significantly suppressed both paclitaxel-induced perforin expression and NK cell cytotoxicity.	pyrrolidine dithiocarbamic acid	21-48	nuclear factor kappa B subunit 1	Homo sapiens	0-10
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	pyrrolidine dithiocarbamic acid	123-150	angiotensinogen	Homo sapiens	0-6
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	pyrrolidine dithiocarbamic acid	123-150	mesenchyme homeobox 2	Homo sapiens	26-29
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	pyrrolidine dithiocarbamic acid	152-156	angiotensinogen	Homo sapiens	0-6
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	pyrrolidine dithiocarbamic acid	152-156	mesenchyme homeobox 2	Homo sapiens	26-29
15725474-5	2005	The DMSO-induced upregulation of PTEN might be mediated by NF-kappaB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	180-207	phosphatase and tensin homolog	Homo sapiens	33-37
15725474-5	2005	The DMSO-induced upregulation of PTEN might be mediated by NF-kappaB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	180-207	phosphatase and tensin homolog	Homo sapiens	133-137
15725474-5	2005	The DMSO-induced upregulation of PTEN might be mediated by NF-kappaB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	209-213	phosphatase and tensin homolog	Homo sapiens	33-37
15725474-5	2005	The DMSO-induced upregulation of PTEN might be mediated by NF-kappaB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	209-213	phosphatase and tensin homolog	Homo sapiens	133-137
15838484-2	2005	The purpose of this study was to determine whether aneurysmal degeneration is influenced by pyrrolidine dithiocarbamate (PDTC), a pharmacologic inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	92-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
15838484-2	2005	The purpose of this study was to determine whether aneurysmal degeneration is influenced by pyrrolidine dithiocarbamate (PDTC), a pharmacologic inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	121-125	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
15838484-9	2005	PDTC-treated mice also exhibited significantly lower serum and aortic wall concentrations of interleukin 1beta and interleukin 6, as well as lower amounts of aortic wall MMP-9, as compared with saline-treated controls.	pyrrolidine dithiocarbamic acid	0-4	interleukin 1 beta	Mus musculus	93-110
15838484-9	2005	PDTC-treated mice also exhibited significantly lower serum and aortic wall concentrations of interleukin 1beta and interleukin 6, as well as lower amounts of aortic wall MMP-9, as compared with saline-treated controls.	pyrrolidine dithiocarbamic acid	0-4	interleukin 6	Mus musculus	115-128
15838484-9	2005	PDTC-treated mice also exhibited significantly lower serum and aortic wall concentrations of interleukin 1beta and interleukin 6, as well as lower amounts of aortic wall MMP-9, as compared with saline-treated controls.	pyrrolidine dithiocarbamic acid	0-4	matrix metallopeptidase 9	Mus musculus	170-175
15838484-14	2005	In this mouse model, treatment with pyrrolidine dithiocarbamate (a pharmacologic inhibitor of NF-kappaB) acted to suppress MMP-9 and aneurysm development.	pyrrolidine dithiocarbamic acid	36-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
15838484-14	2005	In this mouse model, treatment with pyrrolidine dithiocarbamate (a pharmacologic inhibitor of NF-kappaB) acted to suppress MMP-9 and aneurysm development.	pyrrolidine dithiocarbamic acid	36-63	matrix metallopeptidase 9	Mus musculus	123-128
15489374-5	2005	IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	112-139	vascular cell adhesion molecule 1	Homo sapiens	17-23
15489374-5	2005	IL-1beta-induced VCAM-1 expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	112-139	nuclear factor kappa B subunit 1	Homo sapiens	77-86
15240130-7	2004	Addition of an NF-kappaB inhibitor, such as pyrrolidine dithiocarbamate or N-tosyl-l-phenylalanine chloromethyl ketone, to the media aggravated Abeta-induced PC12 cell death.	pyrrolidine dithiocarbamic acid	44-71	amyloid beta precursor protein	Rattus norvegicus	144-149
16435581-3	2005	In addition, the stimulation of IL-6 release also was reduced by the addition of pyrrolidine dithiocarbamate or NF-kappaB SN50, which has been reported as potent NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	81-108	interleukin 6	Homo sapiens	32-36
15968083-5	2005	The antioxidants LY231617, melatonin, and sodium salicylate and the antioxidant and inhibitor of NF-kappaB activation pyrrolidine dithiocarbamate, protected the neurons against the insult and prevented the decrease in cellular IkappaBalpha content.	pyrrolidine dithiocarbamic acid	118-145	NFKB inhibitor alpha	Rattus norvegicus	227-239
15730731-3	2004	NF-kappaB specific inhibitor pyrrolidine dithiocarbamate (PDTC) and PKC agonist phorbol 12-myristate 13-acetate (PMA) were used to intervene HASMCs exposed to asthmatic serum and non-asthmatic control serum.	pyrrolidine dithiocarbamic acid	29-56	nuclear factor kappa B subunit 1	Homo sapiens	0-9
15730731-3	2004	NF-kappaB specific inhibitor pyrrolidine dithiocarbamate (PDTC) and PKC agonist phorbol 12-myristate 13-acetate (PMA) were used to intervene HASMCs exposed to asthmatic serum and non-asthmatic control serum.	pyrrolidine dithiocarbamic acid	58-62	nuclear factor kappa B subunit 1	Homo sapiens	0-9
15308550-8	2004	Furthermore, ADMA-increased oxidative stress was accompanied by a decrease in the activity of dimethylarginine dimethylaminohydrolase (DDAH), the enzyme that degrades ADMA, which could be prevented by the antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	217-244	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	94-133
15308550-8	2004	Furthermore, ADMA-increased oxidative stress was accompanied by a decrease in the activity of dimethylarginine dimethylaminohydrolase (DDAH), the enzyme that degrades ADMA, which could be prevented by the antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	217-244	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	135-139
15289288-8	2004	An inhibitor of the NF-kappaB pathway, pyrrolidine dithiocarbamate (PDTC), as well as inhibitors of JAK2/STAT and ERK, AG490 and U0126, respectively, significantly reduced albumin-induced iNOS expression and NO production, while an inhibitor of the p38 pathway, SB203580, did not significantly affect NO production induced by albumin.	pyrrolidine dithiocarbamic acid	39-66	nitric oxide synthase 2	Homo sapiens	188-192
15289288-8	2004	An inhibitor of the NF-kappaB pathway, pyrrolidine dithiocarbamate (PDTC), as well as inhibitors of JAK2/STAT and ERK, AG490 and U0126, respectively, significantly reduced albumin-induced iNOS expression and NO production, while an inhibitor of the p38 pathway, SB203580, did not significantly affect NO production induced by albumin.	pyrrolidine dithiocarbamic acid	68-72	nitric oxide synthase 2	Homo sapiens	188-192
15919366-5	2004	Exosomes increased nuclear translocation of NF-(kappa)B in naive CD4+ T cells, and NF-(kappa)B activation was significantly suppressed by anti-HLA-DR mAb or NF-(kappa)B inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	179-206	nuclear factor kappa B subunit 1	Homo sapiens	83-94
15919366-5	2004	Exosomes increased nuclear translocation of NF-(kappa)B in naive CD4+ T cells, and NF-(kappa)B activation was significantly suppressed by anti-HLA-DR mAb or NF-(kappa)B inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	179-206	nuclear factor kappa B subunit 1	Homo sapiens	83-94
15919366-5	2004	Exosomes increased nuclear translocation of NF-(kappa)B in naive CD4+ T cells, and NF-(kappa)B activation was significantly suppressed by anti-HLA-DR mAb or NF-(kappa)B inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-212	nuclear factor kappa B subunit 1	Homo sapiens	83-94
15919366-5	2004	Exosomes increased nuclear translocation of NF-(kappa)B in naive CD4+ T cells, and NF-(kappa)B activation was significantly suppressed by anti-HLA-DR mAb or NF-(kappa)B inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-212	nuclear factor kappa B subunit 1	Homo sapiens	83-94
15650183-9	2005	The HCV-induced STAT-3 activation was inhibited in the presence of antioxidant (pyrrolidine dithiocarbamate) and Ca2+ chelators (BAPTA-AM and TMB-8).	pyrrolidine dithiocarbamic acid	80-107	signal transducer and activator of transcription 3	Homo sapiens	16-22
15642134-12	2005	IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-kappaB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively.	pyrrolidine dithiocarbamic acid	113-140	interleukin 17A	Homo sapiens	0-5
15642134-12	2005	IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-kappaB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively.	pyrrolidine dithiocarbamic acid	113-140	nuclear factor kappa B subunit 1	Homo sapiens	93-102
16193640-0	2005	Pyrrolidinedithiocarbamate induces apoptosis in human acute myelogenous leukemic cells affecting NF-kappaB activity.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	97-106
15642795-9	2005	NF-kappaB blocker pyrrolidinedithiocarbamate (PDTC) (10(-4) M) alone did not affect cytotoxicity in T cells.	pyrrolidine dithiocarbamic acid	18-44	nuclear factor kappa B subunit 1	Homo sapiens	0-9
15642795-9	2005	NF-kappaB blocker pyrrolidinedithiocarbamate (PDTC) (10(-4) M) alone did not affect cytotoxicity in T cells.	pyrrolidine dithiocarbamic acid	46-50	nuclear factor kappa B subunit 1	Homo sapiens	0-9
15841722-8	2005	Pretreatment with NAC, PDTC, PD98059 or Genistein significantly decreased MPO levels in the pancreas at 3 and 6 h and following the administration of PD-98059 or NAC at 6 h. Pretreatment with NAC significantly decreased MPO levels in the lungs at 3 h. CONCLUSIONS: Pretreatment with NAC could regulate the pro-and anti-inflammatory cytokine balance, probably through NF-kappaB and ROS signaling pathways.	pyrrolidine dithiocarbamic acid	23-27	myeloperoxidase	Rattus norvegicus	74-77
15841722-8	2005	Pretreatment with NAC, PDTC, PD98059 or Genistein significantly decreased MPO levels in the pancreas at 3 and 6 h and following the administration of PD-98059 or NAC at 6 h. Pretreatment with NAC significantly decreased MPO levels in the lungs at 3 h. CONCLUSIONS: Pretreatment with NAC could regulate the pro-and anti-inflammatory cytokine balance, probably through NF-kappaB and ROS signaling pathways.	pyrrolidine dithiocarbamic acid	23-27	myeloperoxidase	Rattus norvegicus	220-223
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor kappa B subunit 1	Homo sapiens	9-31
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor kappa B subunit 1	Homo sapiens	33-42
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor kappa B subunit 1	Homo sapiens	102-111
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	123-150	tumor necrosis factor	Homo sapiens	185-194
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor kappa B subunit 1	Homo sapiens	9-31
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor kappa B subunit 1	Homo sapiens	33-42
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor kappa B subunit 1	Homo sapiens	102-111
15696609-3	2004	Enhanced nuclear factor-kappa B (NF-kappaB) activation was also induced in Mo-DCs-Tum within 6 h. The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed both IL-12 and TNF-alpha secretions from Mo-DCs-Tum.	pyrrolidine dithiocarbamic acid	152-156	tumor necrosis factor	Homo sapiens	185-194
15557194-4	2004	Interestingly, LPS-induced MMP-9 expression and p38 kinase phosphorylation were shown to be suppressed by the antioxidant N-acetylcysteine and the flavoenzyme inhibitor diphenyleneiodonium chloride, but not by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	210-237	matrix metallopeptidase 9	Mus musculus	27-32
15583145-6	2004	Involvement of NF-kappaB activation was analysed immunocytochemically by anti-NF-kappaB p65 antibody and ammonium pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-kappaB-mediated transcriptional activation.	pyrrolidine dithiocarbamic acid	105-140	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15583145-6	2004	Involvement of NF-kappaB activation was analysed immunocytochemically by anti-NF-kappaB p65 antibody and ammonium pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-kappaB-mediated transcriptional activation.	pyrrolidine dithiocarbamic acid	142-146	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15528384-4	2004	Moreover, the NF-kappaB inhibitors pyrrolidinedithiocarbamate, dexamethasone, or sulfasalazine were found to prevent CXCL8 production by sPLA(2)-IB in human neutrophils.	pyrrolidine dithiocarbamic acid	35-61	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
15481297-3	2004	Because NF-kappaB is activated by both LPS and ROS, we hypothesized that an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), would block release of TNF from the heart stimulated by these two agents.	pyrrolidine dithiocarbamic acid	100-127	tumor necrosis factor	Rattus norvegicus	159-162
15481297-3	2004	Because NF-kappaB is activated by both LPS and ROS, we hypothesized that an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), would block release of TNF from the heart stimulated by these two agents.	pyrrolidine dithiocarbamic acid	129-133	tumor necrosis factor	Rattus norvegicus	159-162
15298726-4	2004	After treatment with these agents, the phosphorylation of protein kinase A, Bcl-2 (Thr56) and Bad (Ser155) was increased, especially in antioxidant (N-acetylcysteine and pyrrolidine dithiocarbamate)-pretreated control cells, but the phosphorylation levels were very low in the antisense-transfected cells.	pyrrolidine dithiocarbamic acid	170-197	BCL2 apoptosis regulator	Homo sapiens	76-81
15242777-4	2004	Here, we have found that treatment of pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, resulted in the accumulation of several proteasome substrates including p53 and p21 in HeLa cells.	pyrrolidine dithiocarbamic acid	38-65	tumor protein p53	Homo sapiens	164-167
15242777-4	2004	Here, we have found that treatment of pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, resulted in the accumulation of several proteasome substrates including p53 and p21 in HeLa cells.	pyrrolidine dithiocarbamic acid	38-65	H3 histone pseudogene 16	Homo sapiens	172-175
15242777-4	2004	Here, we have found that treatment of pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, resulted in the accumulation of several proteasome substrates including p53 and p21 in HeLa cells.	pyrrolidine dithiocarbamic acid	67-71	tumor protein p53	Homo sapiens	164-167
15242777-4	2004	Here, we have found that treatment of pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, resulted in the accumulation of several proteasome substrates including p53 and p21 in HeLa cells.	pyrrolidine dithiocarbamic acid	67-71	H3 histone pseudogene 16	Homo sapiens	172-175
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	48-52	interferon gamma	Homo sapiens	154-170
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	48-52	interferon gamma	Homo sapiens	172-181
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	48-52	CD80 molecule	Homo sapiens	210-214
15265881-5	2004	The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbamate efficiently inhibited the induction of IRF-7 by HSV or LPS, and also down-regulated the constitutive expression of IRF-7 in PDC and blocked the HSV-induced production of IFN-alpha.	pyrrolidine dithiocarbamic acid	36-62	nuclear factor kappa B subunit 1	Homo sapiens	4-14
15265881-5	2004	The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbamate efficiently inhibited the induction of IRF-7 by HSV or LPS, and also down-regulated the constitutive expression of IRF-7 in PDC and blocked the HSV-induced production of IFN-alpha.	pyrrolidine dithiocarbamic acid	36-62	interferon regulatory factor 7	Homo sapiens	102-107
15265881-5	2004	The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbamate efficiently inhibited the induction of IRF-7 by HSV or LPS, and also down-regulated the constitutive expression of IRF-7 in PDC and blocked the HSV-induced production of IFN-alpha.	pyrrolidine dithiocarbamic acid	36-62	interferon regulatory factor 7	Homo sapiens	178-183
15265881-5	2004	The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbamate efficiently inhibited the induction of IRF-7 by HSV or LPS, and also down-regulated the constitutive expression of IRF-7 in PDC and blocked the HSV-induced production of IFN-alpha.	pyrrolidine dithiocarbamic acid	36-62	interferon alpha 1	Homo sapiens	233-242
15240151-7	2004	Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	140-167	interleukin 1 beta	Homo sapiens	13-21
15240151-7	2004	Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	140-167	defensin beta 4A	Homo sapiens	30-35
15240151-7	2004	Importantly, IL-1beta-induced HBD-2 mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	140-167	nuclear factor kappa B subunit 1	Homo sapiens	81-90
15137068-7	2004	UV-induced enhanced apoptotic susceptibility was reduced by over-expression of decoy receptor TRAIL-R4, but not TRAIL-R3; or treatment with thiol compound pyrrolidine dithiocarbamate (PDTC), which also enhanced TRAIL-R4 levels.	pyrrolidine dithiocarbamic acid	155-182	TNF receptor superfamily member 10d	Homo sapiens	211-219
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	182-209	nuclear factor kappa B subunit 1	Homo sapiens	81-90
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	182-209	nuclear factor kappa B subunit 1	Homo sapiens	154-163
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	182-209	X-linked Kx blood group	Homo sapiens	265-268
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	211-215	nuclear factor kappa B subunit 1	Homo sapiens	81-90
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	211-215	nuclear factor kappa B subunit 1	Homo sapiens	154-163
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	pyrrolidine dithiocarbamic acid	211-215	X-linked Kx blood group	Homo sapiens	265-268
15532722-8	2004	Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur.	pyrrolidine dithiocarbamic acid	183-187	interleukin 1 beta	Homo sapiens	43-51
15532722-8	2004	Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur.	pyrrolidine dithiocarbamic acid	183-187	interleukin 6	Homo sapiens	53-57
15532722-8	2004	Both the fever and the increased levels of IL-1beta, IL-6, and TNF-alpha in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with either PDTC, Pyri, NAC, or Cur.	pyrrolidine dithiocarbamic acid	183-187	tumor necrosis factor	Homo sapiens	63-72
14731112-10	2004	MG132 can ablate IkappaBalpha degradation and NF-kappaB (nuclear factor kappaB) activation induced by lipopolysaccharide, similar to the effect of another NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	175-202	nuclear factor kappa B subunit 1	Homo sapiens	155-164
15178336-3	2004	Inhibition of the NF-kappa B signal by pyrrolidine dithiocarbamate (PDTC) blocked NO production and microfilaricidal activity of C57Bl/6 macrophages and inclusion of the exogenous NO generator (SNP) in the PDTC treated C57Bl/6 macrophage cultures induced mf cytotoxicity.	pyrrolidine dithiocarbamic acid	39-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-28
15178336-3	2004	Inhibition of the NF-kappa B signal by pyrrolidine dithiocarbamate (PDTC) blocked NO production and microfilaricidal activity of C57Bl/6 macrophages and inclusion of the exogenous NO generator (SNP) in the PDTC treated C57Bl/6 macrophage cultures induced mf cytotoxicity.	pyrrolidine dithiocarbamic acid	68-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-28
15171291-2	2004	The extraction behaviors of ammonium pyrrolidinedithiocarbamate (APDC) for both Cr6+ and Cr3+ are carefully discussed in this report.	pyrrolidine dithiocarbamic acid	28-63	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	80-83
15171291-2	2004	The extraction behaviors of ammonium pyrrolidinedithiocarbamate (APDC) for both Cr6+ and Cr3+ are carefully discussed in this report.	pyrrolidine dithiocarbamic acid	28-63	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	89-92
15171291-2	2004	The extraction behaviors of ammonium pyrrolidinedithiocarbamate (APDC) for both Cr6+ and Cr3+ are carefully discussed in this report.	pyrrolidine dithiocarbamic acid	65-69	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	80-83
15171291-2	2004	The extraction behaviors of ammonium pyrrolidinedithiocarbamate (APDC) for both Cr6+ and Cr3+ are carefully discussed in this report.	pyrrolidine dithiocarbamic acid	65-69	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	89-92
15171291-3	2004	X-ray diffraction and spectroscopic studies indicate that Cr6+ reacts with the ammonium pyrrolidinedithiocarbamate ligand to form two products, Cr(PDC)2(OPDC) and Cr(PDC)3, where OPDC represents an oxygen insertion between Cr and S atoms.	pyrrolidine dithiocarbamic acid	79-114	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	58-61
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	19-46	nuclear factor kappa B subunit 1	Homo sapiens	77-86
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	19-46	interferon gamma	Homo sapiens	154-170
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	19-46	interferon gamma	Homo sapiens	172-181
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	19-46	CD80 molecule	Homo sapiens	210-214
15254772-2	2004	Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes.	pyrrolidine dithiocarbamic acid	48-52	nuclear factor kappa B subunit 1	Homo sapiens	77-86
15043947-4	2004	Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, significantly blocked poly I:C induced luciferase accumulation in RTG-P1 at intermediate doses (1-10 microM), suggesting that Mx1 induction through the IFN signalling pathway is NF-kappaB-dependent in fish.	pyrrolidine dithiocarbamic acid	0-27	interferon-induced GTP-binding protein Mx1	Oncorhynchus mykiss	186-189
15043947-4	2004	Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, significantly blocked poly I:C induced luciferase accumulation in RTG-P1 at intermediate doses (1-10 microM), suggesting that Mx1 induction through the IFN signalling pathway is NF-kappaB-dependent in fish.	pyrrolidine dithiocarbamic acid	29-33	interferon-induced GTP-binding protein Mx1	Oncorhynchus mykiss	186-189
15147565-6	2004	Activation of NF-kappaB was shown to be critical for up-regulation of CD80 expression as pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, severely decreased the observed up-regulation.	pyrrolidine dithiocarbamic acid	89-116	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
15147565-6	2004	Activation of NF-kappaB was shown to be critical for up-regulation of CD80 expression as pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, severely decreased the observed up-regulation.	pyrrolidine dithiocarbamic acid	89-116	CD80 antigen	Mus musculus	70-74
15147565-6	2004	Activation of NF-kappaB was shown to be critical for up-regulation of CD80 expression as pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, severely decreased the observed up-regulation.	pyrrolidine dithiocarbamic acid	89-116	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-150
14731112-11	2004	We found HO-1 upregulation by MG132 and pyrrolidine dithiocarbamate is unrelated to their inhibition of NF-kappaB, since leptomycin B, another NF-kappaB inhibitor, did not elicit similar induction of HO-1.	pyrrolidine dithiocarbamic acid	40-67	heme oxygenase 1	Homo sapiens	9-13
15067222-8	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	97-123	interleukin 1 beta	Homo sapiens	0-8
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	96-122	tumor necrosis factor	Homo sapiens	0-9
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	96-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	124-128	tumor necrosis factor	Homo sapiens	0-9
14751545-7	2004	TNF-alpha-induced COX-2 expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	124-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
15067222-8	2004	IL-1beta-induced COX-2 expression and PGE(2) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	97-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15048878-7	2004	Pyrrolidine dithiocarbamate (PDTC) decreased p27 and p21 levels in cycling AAM cells relative to controls in a substrate-dependent manner.	pyrrolidine dithiocarbamic acid	0-27	interferon alpha inducible protein 27	Homo sapiens	45-48
15048878-7	2004	Pyrrolidine dithiocarbamate (PDTC) decreased p27 and p21 levels in cycling AAM cells relative to controls in a substrate-dependent manner.	pyrrolidine dithiocarbamic acid	0-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-56
15048878-7	2004	Pyrrolidine dithiocarbamate (PDTC) decreased p27 and p21 levels in cycling AAM cells relative to controls in a substrate-dependent manner.	pyrrolidine dithiocarbamic acid	29-33	interferon alpha inducible protein 27	Homo sapiens	45-48
15048878-7	2004	Pyrrolidine dithiocarbamate (PDTC) decreased p27 and p21 levels in cycling AAM cells relative to controls in a substrate-dependent manner.	pyrrolidine dithiocarbamic acid	29-33	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-56
15094475-3	2004	By using cultured cortical astrocytes, we show that a short ethanol treatment (100 mM) is able to up-regulate both cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, and that these effects are regulated via nuclear factor kappa B (NF-kappa B) as revealed by the inhibition of NF-kappa B activation with pyrrolidine dithiocarbamate (PDTC) or BAY 11-7082.	pyrrolidine dithiocarbamic acid	332-359	nitric oxide synthase 2	Homo sapiens	177-181
15094475-3	2004	By using cultured cortical astrocytes, we show that a short ethanol treatment (100 mM) is able to up-regulate both cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, and that these effects are regulated via nuclear factor kappa B (NF-kappa B) as revealed by the inhibition of NF-kappa B activation with pyrrolidine dithiocarbamate (PDTC) or BAY 11-7082.	pyrrolidine dithiocarbamic acid	361-365	nitric oxide synthase 2	Homo sapiens	177-181
15005272-4	2004	Shear stress-induced iNOS expression was inhibited by pyrrolidine dithiocarbamate (PDTC), an antioxidant and nuclear factor kappaB (NF-kappaB) blocker, and by MG132, an aldehyde peptide proteasome inhibitor that antagonizes I kappaB-kinase.	pyrrolidine dithiocarbamic acid	54-81	nitric oxide synthase 2	Homo sapiens	21-25
15102481-10	2004	CONCLUSION: These findings suggest that PDTC-induced apoptosis is related with Bax, and that G1 arrest is possibly related with p21.	pyrrolidine dithiocarbamic acid	40-44	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
14592944-4	2004	The iron chelator pyrrolidinedithiocarbamate (PDTC) stimulated hepatic hepcidin without suppressing intestinal FPT1 expression.	pyrrolidine dithiocarbamic acid	18-44	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
14592944-4	2004	The iron chelator pyrrolidinedithiocarbamate (PDTC) stimulated hepatic hepcidin without suppressing intestinal FPT1 expression.	pyrrolidine dithiocarbamic acid	46-50	hepcidin antimicrobial peptide	Rattus norvegicus	71-79
14633657-9	2004	Topical application of inhibitors of NF-kappaB, such as pyrrolidine dithiocarbamate or N-alpha-p-tosyl-l-lysine chloromethylketone, inhibited the SNP-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	56-83	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
14633657-9	2004	Topical application of inhibitors of NF-kappaB, such as pyrrolidine dithiocarbamate or N-alpha-p-tosyl-l-lysine chloromethylketone, inhibited the SNP-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	56-83	prostaglandin-endoperoxide synthase 2	Mus musculus	158-163
15014040-7	2004	A NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed both MMP-9 expression and invasiveness of IL-1beta-treated GCTM-1 cells.	pyrrolidine dithiocarbamic acid	23-50	nuclear factor kappa B subunit 1	Homo sapiens	2-11
15014040-7	2004	A NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed both MMP-9 expression and invasiveness of IL-1beta-treated GCTM-1 cells.	pyrrolidine dithiocarbamic acid	23-50	matrix metallopeptidase 9	Homo sapiens	68-73
15014040-7	2004	A NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed both MMP-9 expression and invasiveness of IL-1beta-treated GCTM-1 cells.	pyrrolidine dithiocarbamic acid	23-50	interleukin 1 beta	Homo sapiens	105-113
14977935-6	2004	Furthermore, an NF-kappaB inhibitor (pyrrolidine dithiocarbamate), a mitogen-activated protein (MAP) kinase (MEK) inhibitor (PD98059), and a p38 MAP kinase inhibitor (SB203580) significantly suppressed IL-8 synthesis in neutrophils.	pyrrolidine dithiocarbamic acid	37-64	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
14978110-10	2004	A potent inhibitor for NF-kappaB (pyrrolidine dithiocarbamate) significantly blocked the rFliC-primed increase in O(2)(-) production and induction of Nox1 protein.	pyrrolidine dithiocarbamic acid	34-61	NADPH oxidase 1	Homo sapiens	150-154
15005272-4	2004	Shear stress-induced iNOS expression was inhibited by pyrrolidine dithiocarbamate (PDTC), an antioxidant and nuclear factor kappaB (NF-kappaB) blocker, and by MG132, an aldehyde peptide proteasome inhibitor that antagonizes I kappaB-kinase.	pyrrolidine dithiocarbamic acid	83-87	nitric oxide synthase 2	Homo sapiens	21-25
14742681-5	2004	Preincubation with the SP-1 inhibitor mithramycin as well as blockade of nuclear factor (NF)-kappaB signaling with pyrrolidine dithiocarbamate treatment and IkappaB transfection reduced significantly the transcription of VEGF, indicating that both transcription factors contribute to the activation of VEGF by SA 981.	pyrrolidine dithiocarbamic acid	115-142	vascular endothelial growth factor A	Homo sapiens	221-225
14732362-3	2004	Prior treatment of the donor of either the aorta or the arteriole with pyrrolidine dithiocarbamate (PDTC), a potent NF-kappaB inhibitor, prevented the loss of tone.	pyrrolidine dithiocarbamic acid	71-98	nuclear factor kappa B subunit 1	Homo sapiens	116-125
14730209-10	2004	A specific inhibitor of p38 MAPK (SB203580) and an NF-kappaB inhibitor (pyrrolidine dithiocarbamate), but not an ERK inhibitor (PD 98059), significantly inhibited neutrophil elastase-induced IL-8 release and mRNA expression.	pyrrolidine dithiocarbamic acid	72-99	nuclear factor kappa B subunit 1	Homo sapiens	51-60
14730209-10	2004	A specific inhibitor of p38 MAPK (SB203580) and an NF-kappaB inhibitor (pyrrolidine dithiocarbamate), but not an ERK inhibitor (PD 98059), significantly inhibited neutrophil elastase-induced IL-8 release and mRNA expression.	pyrrolidine dithiocarbamic acid	72-99	elastase, neutrophil expressed	Homo sapiens	163-182
14980010-5	2004	The increased production of NO and TNF-alpha from rIFN-gamma plus C. majus-stimulated cells was almost completely inhibited by nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (100 microM).	pyrrolidine dithiocarbamic acid	172-199	interferon gamma	Rattus norvegicus	50-60
14732362-3	2004	Prior treatment of the donor of either the aorta or the arteriole with pyrrolidine dithiocarbamate (PDTC), a potent NF-kappaB inhibitor, prevented the loss of tone.	pyrrolidine dithiocarbamic acid	100-104	nuclear factor kappa B subunit 1	Homo sapiens	116-125
15274191-6	2004	Expression of iNOS mRNA had a 167-fold increase from normal in controls, but was significantly (P < 0.05) reduced to a 63-fold increase in PDTC-treated muscles.	pyrrolidine dithiocarbamic acid	142-146	nitric oxide synthase 2	Rattus norvegicus	14-18
14660032-6	2003	Furthermore, pyrrolidine dithiocarbamate markedly reduced the expression of inducible nitric oxide synthase (iNOS) protein and significantly reduced serum levels of nitric oxide.	pyrrolidine dithiocarbamic acid	13-40	nitric oxide synthase 2	Rattus norvegicus	76-107
14660032-6	2003	Furthermore, pyrrolidine dithiocarbamate markedly reduced the expression of inducible nitric oxide synthase (iNOS) protein and significantly reduced serum levels of nitric oxide.	pyrrolidine dithiocarbamic acid	13-40	nitric oxide synthase 2	Rattus norvegicus	109-113
12924514-6	2003	The addition of pyrrolidinedithiocarbamate, a chemical NF-kappaB blocking agent, inhibited IL-6 and IL-8 secretion as well as the NF-kappaB reporter gene activity.	pyrrolidine dithiocarbamic acid	16-42	interleukin 6	Sus scrofa	91-95
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	152-160
14566967-6	2003	Pyrrolidine dithiocarbamate (PDTC), a scavenger of reactive oxygen species (ROS) blocked apoptosis induction by CH-11/PSI as well as the enhancement by IL-1beta.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 beta	Homo sapiens	152-160
14697299-0	2003	Induction of heme oxygenase-1 and dilatation of hepatic sinusoids by an administration of pyrrolidine dithiocarbamate in rat livers.	pyrrolidine dithiocarbamic acid	90-117	heme oxygenase 1	Rattus norvegicus	13-29
14697299-2	2003	In this article, we report our use of pyrrolidine dithiocarbamate (PDTC) to induce HO-1 in the liver in vivo and its impact on hepatic microcirculation.	pyrrolidine dithiocarbamic acid	38-65	heme oxygenase 1	Rattus norvegicus	83-87
14697299-2	2003	In this article, we report our use of pyrrolidine dithiocarbamate (PDTC) to induce HO-1 in the liver in vivo and its impact on hepatic microcirculation.	pyrrolidine dithiocarbamic acid	67-71	heme oxygenase 1	Rattus norvegicus	83-87
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	pyrrolidine dithiocarbamic acid	89-116	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-174
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	pyrrolidine dithiocarbamic acid	89-116	matrix metallopeptidase 3	Mus musculus	252-265
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	pyrrolidine dithiocarbamic acid	118-122	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-174
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	pyrrolidine dithiocarbamic acid	118-122	jun proto-oncogene	Mus musculus	179-183
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	pyrrolidine dithiocarbamic acid	118-122	matrix metallopeptidase 3	Mus musculus	252-265
14641910-5	2003	Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	107-134	tumor necrosis factor	Homo sapiens	12-15
14641910-5	2003	Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	107-134	nuclear factor kappa B subunit 1	Homo sapiens	92-101
14641910-5	2003	Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	136-140	tumor necrosis factor	Homo sapiens	12-15
14641910-5	2003	Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	136-140	nuclear factor kappa B subunit 1	Homo sapiens	92-101
14606858-8	2003	Cr(N)(pyr-dtc)(2) (3) crystallizes as orange prisms in the monoclinic space group P21/c with cell parameters a = 14.8592(14) A, b = 8.5575(5) A, c = 11.8267(12) A, beta = 106.528(7) degrees, V = 1441.7(2) A(3), Z = 4.	pyrrolidine dithiocarbamic acid	6-13	H3 histone pseudogene 16	Homo sapiens	82-85
12893643-6	2003	We report that these mediators are markedly decreased by pyrrolidinedithiocarbamate, an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	57-83	nuclear factor kappa B subunit 1	Homo sapiens	101-110
14627497-4	2003	Furthermore, PDTC and NAC prevented the decrease (from 0.50+/-0.10 to 0.80+/-0.20 or 1.20+/-0.24, respectively) and phosphorylation (from 2.00+/-0.15 to 0.46+/-0.10 or 0.41+/-0.10, respectively) of IkappaBalpha protein in the cytoplasm.	pyrrolidine dithiocarbamic acid	13-17	NFKB inhibitor alpha	Rattus norvegicus	198-210
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	pyrrolidine dithiocarbamic acid	63-90	tumor necrosis factor	Homo sapiens	135-143
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	pyrrolidine dithiocarbamic acid	63-90	intercellular adhesion molecule 1	Homo sapiens	152-158
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	pyrrolidine dithiocarbamic acid	92-96	tumor necrosis factor	Homo sapiens	135-143
14572618-1	2003	We demonstrate that two different cell-permeable antioxidants, pyrrolidine dithiocarbamate (PDTC) and dimethylthiourea (DMTU), inhibit TNFalpha-induced ICAM-1 surface and gene expression in primary cultures of differentiated normal human bronchial epithelial (NHBE) cells.	pyrrolidine dithiocarbamic acid	92-96	intercellular adhesion molecule 1	Homo sapiens	152-158
12876287-10	2003	Pyrrolidine dithiocarbamate, a scavenger of H2O2, reduces insulin-induced gene expression but not hypoxia-induced gene expression.	pyrrolidine dithiocarbamic acid	0-27	insulin	Homo sapiens	58-65
14575590-12	2003	Pyrrolidine dithiocarbamate (PDTC, 10(-4) mol/L), an inhibitor of NF-kappaB, or AT1R antagonist losartan (10(-5)mol/L) inhibited AngII-induced NF-kappaB translocation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	66-75
14575590-12	2003	Pyrrolidine dithiocarbamate (PDTC, 10(-4) mol/L), an inhibitor of NF-kappaB, or AT1R antagonist losartan (10(-5)mol/L) inhibited AngII-induced NF-kappaB translocation.	pyrrolidine dithiocarbamic acid	0-27	angiotensinogen	Homo sapiens	129-134
14575590-12	2003	Pyrrolidine dithiocarbamate (PDTC, 10(-4) mol/L), an inhibitor of NF-kappaB, or AT1R antagonist losartan (10(-5)mol/L) inhibited AngII-induced NF-kappaB translocation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	143-152
14575590-12	2003	Pyrrolidine dithiocarbamate (PDTC, 10(-4) mol/L), an inhibitor of NF-kappaB, or AT1R antagonist losartan (10(-5)mol/L) inhibited AngII-induced NF-kappaB translocation.	pyrrolidine dithiocarbamic acid	29-33	angiotensinogen	Homo sapiens	129-134
14575590-12	2003	Pyrrolidine dithiocarbamate (PDTC, 10(-4) mol/L), an inhibitor of NF-kappaB, or AT1R antagonist losartan (10(-5)mol/L) inhibited AngII-induced NF-kappaB translocation.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	143-152
12865654-8	2003	Pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappaB-dependent gene expression, dose dependently decreased HO-1 mRNA transcripts in human mononuclear cells subjected to oxidative stress while slightly increasing HO-1 gene expression in HepG2 cells.	pyrrolidine dithiocarbamic acid	0-27	heme oxygenase 1	Homo sapiens	121-125
12865654-8	2003	Pyrrolidine dithiocarbamate, an inhibitor of nuclear factor kappaB-dependent gene expression, dose dependently decreased HO-1 mRNA transcripts in human mononuclear cells subjected to oxidative stress while slightly increasing HO-1 gene expression in HepG2 cells.	pyrrolidine dithiocarbamic acid	0-27	heme oxygenase 1	Homo sapiens	226-230
14511644-7	2003	Furthermore, antioxidants, N-acetyl-cysteine and pyrrolidinedithiocarbamate (PDTC), completely abolished the increase of HBx protein induced by adriamycin, indicating that adriamycin modulates the intracellular HBx level via ROS generation.	pyrrolidine dithiocarbamic acid	49-75	X protein	Hepatitis B virus	121-124
14511644-7	2003	Furthermore, antioxidants, N-acetyl-cysteine and pyrrolidinedithiocarbamate (PDTC), completely abolished the increase of HBx protein induced by adriamycin, indicating that adriamycin modulates the intracellular HBx level via ROS generation.	pyrrolidine dithiocarbamic acid	49-75	X protein	Hepatitis B virus	211-214
14511644-7	2003	Furthermore, antioxidants, N-acetyl-cysteine and pyrrolidinedithiocarbamate (PDTC), completely abolished the increase of HBx protein induced by adriamycin, indicating that adriamycin modulates the intracellular HBx level via ROS generation.	pyrrolidine dithiocarbamic acid	77-81	X protein	Hepatitis B virus	121-124
14511644-7	2003	Furthermore, antioxidants, N-acetyl-cysteine and pyrrolidinedithiocarbamate (PDTC), completely abolished the increase of HBx protein induced by adriamycin, indicating that adriamycin modulates the intracellular HBx level via ROS generation.	pyrrolidine dithiocarbamic acid	77-81	X protein	Hepatitis B virus	211-214
12946329-7	2003	Pretreatment of the BEAS-2B cells with the NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC), MG-132, and SN50 resulted in a marked decrease in B. pertussis-induced ICAM-1 expression, implying the involvement of NF-kappa B in ICAM-1 expression.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor kappa B subunit 1	Homo sapiens	43-53
12946329-7	2003	Pretreatment of the BEAS-2B cells with the NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC), MG-132, and SN50 resulted in a marked decrease in B. pertussis-induced ICAM-1 expression, implying the involvement of NF-kappa B in ICAM-1 expression.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor kappa B subunit 1	Homo sapiens	219-229
12946329-7	2003	Pretreatment of the BEAS-2B cells with the NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC), MG-132, and SN50 resulted in a marked decrease in B. pertussis-induced ICAM-1 expression, implying the involvement of NF-kappa B in ICAM-1 expression.	pyrrolidine dithiocarbamic acid	94-98	nuclear factor kappa B subunit 1	Homo sapiens	43-53
12946329-7	2003	Pretreatment of the BEAS-2B cells with the NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC), MG-132, and SN50 resulted in a marked decrease in B. pertussis-induced ICAM-1 expression, implying the involvement of NF-kappa B in ICAM-1 expression.	pyrrolidine dithiocarbamic acid	94-98	nuclear factor kappa B subunit 1	Homo sapiens	219-229
12878048-5	2003	In HeLa cells, pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, and zinc itself inhibited NF-kappaB activity.	pyrrolidine dithiocarbamic acid	15-42	nuclear factor kappa B subunit 1	Homo sapiens	95-104
12883201-11	2003	The cold/rewarming-induced IL-8 production was reduced to approximately 50% by introducing an antisense oligonucleotide for the p65 subunit of NF-kappaB and by treatment with N-acetyl-leucinyl-leucinyl-norleucinal and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	218-245	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12883201-11	2003	The cold/rewarming-induced IL-8 production was reduced to approximately 50% by introducing an antisense oligonucleotide for the p65 subunit of NF-kappaB and by treatment with N-acetyl-leucinyl-leucinyl-norleucinal and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	218-245	RELA proto-oncogene, NF-kB subunit	Homo sapiens	128-152
12878048-5	2003	In HeLa cells, pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, and zinc itself inhibited NF-kappaB activity.	pyrrolidine dithiocarbamic acid	44-48	nuclear factor kappa B subunit 1	Homo sapiens	95-104
12901850-3	2003	Pretreatment of cells with pyrrolidine dithiocarbamate or with antioxidants, which scavenge hydroxyl radical, dimethyl sulfoxide (DMSO), or dimetylthiourea (DMTU) completely abrogated NO-dependent induction of IL-8 gene expression.	pyrrolidine dithiocarbamic acid	27-54	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12605880-0	2003	Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases.	pyrrolidine dithiocarbamic acid	0-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	13-40	nuclear factor kappa B subunit 1	Homo sapiens	52-63
12845421-5	2003	Pyrrolidine dithiocarbamate and N-alpha-para-tosyl-L-lysine chloromethyl ketone, two known inhibitors of NF-kappa B activation, decreased significantly NO production and iNOS protein expression as well as NF-kappa B/DNA binding activity.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-115
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	13-40	insulin like growth factor 1	Homo sapiens	115-120
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	13-40	interleukin 4	Homo sapiens	124-128
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	13-40	Fc epsilon receptor II	Homo sapiens	137-141
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	42-46	nuclear factor kappa B subunit 1	Homo sapiens	52-63
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	42-46	insulin like growth factor 1	Homo sapiens	115-120
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	42-46	interleukin 4	Homo sapiens	124-128
12872985-8	2003	In contrast, pyrrolidine dithiocarbamate (PDTC), an NF-(kappa)B inhibitor, only suppressed the enhancing effect of IGF-1 on IL-4-induced CD23 expression.	pyrrolidine dithiocarbamic acid	42-46	Fc epsilon receptor II	Homo sapiens	137-141
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	32-59	cytochrome c, somatic	Homo sapiens	77-89
12845421-5	2003	Pyrrolidine dithiocarbamate and N-alpha-para-tosyl-L-lysine chloromethyl ketone, two known inhibitors of NF-kappa B activation, decreased significantly NO production and iNOS protein expression as well as NF-kappa B/DNA binding activity.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2, inducible	Mus musculus	170-174
12845421-5	2003	Pyrrolidine dithiocarbamate and N-alpha-para-tosyl-L-lysine chloromethyl ketone, two known inhibitors of NF-kappa B activation, decreased significantly NO production and iNOS protein expression as well as NF-kappa B/DNA binding activity.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-215
12576300-8	2003	Finally, antioxidant agents (N-acetyl cysteine and pyrrolidine dithiocarbamate), which inhibited NF-kappaB activation but failed to affect STAT6 activation, almost completely attenuated DEP-induced eotaxin production, whereas these agents failed to attenuate IL-13-induced eotaxin production.	pyrrolidine dithiocarbamic acid	51-78	C-C motif chemokine ligand 11	Homo sapiens	198-205
12576300-8	2003	Finally, antioxidant agents (N-acetyl cysteine and pyrrolidine dithiocarbamate), which inhibited NF-kappaB activation but failed to affect STAT6 activation, almost completely attenuated DEP-induced eotaxin production, whereas these agents failed to attenuate IL-13-induced eotaxin production.	pyrrolidine dithiocarbamic acid	51-78	interleukin 13	Homo sapiens	259-264
12576300-8	2003	Finally, antioxidant agents (N-acetyl cysteine and pyrrolidine dithiocarbamate), which inhibited NF-kappaB activation but failed to affect STAT6 activation, almost completely attenuated DEP-induced eotaxin production, whereas these agents failed to attenuate IL-13-induced eotaxin production.	pyrrolidine dithiocarbamic acid	51-78	C-C motif chemokine ligand 11	Homo sapiens	273-280
12924514-6	2003	The addition of pyrrolidinedithiocarbamate, a chemical NF-kappaB blocking agent, inhibited IL-6 and IL-8 secretion as well as the NF-kappaB reporter gene activity.	pyrrolidine dithiocarbamic acid	16-42	C-X-C motif chemokine ligand 8	Sus scrofa	100-104
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	32-59	caspase 3	Homo sapiens	99-108
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	32-59	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	61-65	cytochrome c, somatic	Homo sapiens	77-89
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	61-65	caspase 3	Homo sapiens	99-108
12766487-8	2003	Treatment with the anti-oxidant pyrrolidine dithiocarbamate (PDTC) inhibited cytochrome c release, caspase-3 activation and PARP cleavage associated with PDT thereby supporting the contention that QLT0074 induces apoptosis through the generation of reactive oxygen species upon light activation.	pyrrolidine dithiocarbamic acid	61-65	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
12892381-5	2003	On the other hand, the enhanced release of TNF-alpha was completely suppressed by U73122, and strongly suppressed by TMB-8 (which inhibits calcium release from the endoplasmic reticulum) and W-7, and weakly suppressed by pyrrolidine dithiocarbamate (a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	221-248	tumor necrosis factor	Rattus norvegicus	43-52
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	interferon gamma	Rattus norvegicus	36-46
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-200
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	202-211
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	155-159	interferon gamma	Rattus norvegicus	36-46
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	155-159	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-200
12860059-4	2003	The increased production of NO from rIFN-gamma plus SR-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	155-159	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	202-211
12873427-4	2003	We hypothesized that the antioxidant pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB and upregulator of HSP70, would decrease lung injury after ischemia and reperfusion.	pyrrolidine dithiocarbamic acid	37-64	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	118-123
12873427-4	2003	We hypothesized that the antioxidant pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB and upregulator of HSP70, would decrease lung injury after ischemia and reperfusion.	pyrrolidine dithiocarbamic acid	66-70	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	118-123
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-106
12704788-3	2003	In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis.	pyrrolidine dithiocarbamic acid	123-149	interferon gamma	Homo sapiens	205-214
12704788-3	2003	In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis.	pyrrolidine dithiocarbamic acid	151-155	interferon gamma	Homo sapiens	205-214
12704788-7	2003	Both PDTC and indomethacin also blocked IFN-gamma-induced release of cytochrome c from mitochondria.	pyrrolidine dithiocarbamic acid	5-9	interferon gamma	Homo sapiens	40-49
12704788-7	2003	Both PDTC and indomethacin also blocked IFN-gamma-induced release of cytochrome c from mitochondria.	pyrrolidine dithiocarbamic acid	5-9	cytochrome c, somatic	Homo sapiens	69-81
12697280-5	2003	Using a rabbit antibody, IkappaB phosphorylation (and degradation) was stimulated by low [Mg(2+)](o) (in a concentration-dependent manner) and inhibited by a low concentration of the NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	204-231	nuclear factor kappa B subunit 1	Homo sapiens	183-192
12714616-14	2003	The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2.	pyrrolidine dithiocarbamic acid	24-50	interleukin 1 beta	Homo sapiens	151-159
12714616-14	2003	The NFkappaB inhibitors pyrrolidinedithiocarbamate (PDTC; 100 microM), caffeic acid phenethyl ester (CAPE; 90 microM), and MG-132 (25 microM), blocked IL-1beta-stimulated expression of hBD-2.	pyrrolidine dithiocarbamic acid	24-50	defensin beta 4A	Homo sapiens	185-190
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	pyrrolidine dithiocarbamic acid	77-104	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	pyrrolidine dithiocarbamic acid	106-110	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139
12782181-8	2003	Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production.	pyrrolidine dithiocarbamic acid	38-64	nuclear factor kappa B subunit 1	Homo sapiens	17-27
12782181-8	2003	Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production.	pyrrolidine dithiocarbamic acid	38-64	nitric oxide synthase 2	Homo sapiens	101-105
12782181-8	2003	Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production.	pyrrolidine dithiocarbamic acid	66-70	nuclear factor kappa B subunit 1	Homo sapiens	17-27
12782181-8	2003	Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production.	pyrrolidine dithiocarbamic acid	66-70	nitric oxide synthase 2	Homo sapiens	101-105
12657749-0	2003	Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.	pyrrolidine dithiocarbamic acid	64-91	mitogen-activated protein kinase 1	Homo sapiens	0-3
12657749-0	2003	Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.	pyrrolidine dithiocarbamic acid	64-91	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
12657749-0	2003	Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.	pyrrolidine dithiocarbamic acid	64-91	glutamate-cysteine ligase modifier subunit	Homo sapiens	105-141
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	0-27	glutamate-cysteine ligase modifier subunit	Homo sapiens	58-94
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	0-27	glutamate-cysteine ligase modifier subunit	Homo sapiens	96-100
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 1	Homo sapiens	183-213
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 1	Homo sapiens	215-218
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 1	Homo sapiens	224-227
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	29-33	glutamate-cysteine ligase modifier subunit	Homo sapiens	58-94
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	29-33	glutamate-cysteine ligase modifier subunit	Homo sapiens	96-100
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 1	Homo sapiens	183-213
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 1	Homo sapiens	215-218
12657749-1	2003	Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (MAPKs) extracellular regulated kinase (Erk) and p38, and is not affected by protein kinase C (PKC) or PI3K inhibitors.	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 1	Homo sapiens	224-227
12719791-7	2003	Treatment with the antioxidant pyr-rolidinedithiocarbamate or coexpression of the redox factor-1 restored HIF-1 and PAI-1 promoter activity in RacG12V-cells.	pyrrolidine dithiocarbamic acid	31-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-111
12719791-7	2003	Treatment with the antioxidant pyr-rolidinedithiocarbamate or coexpression of the redox factor-1 restored HIF-1 and PAI-1 promoter activity in RacG12V-cells.	pyrrolidine dithiocarbamic acid	31-58	serpin family E member 1	Homo sapiens	116-121
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	jun proto-oncogene	Mus musculus	111-115
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	interleukin 2	Mus musculus	156-160
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	interleukin 2	Mus musculus	215-219
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	granzyme A	Mus musculus	252-262
12773984-0	2003	Pyrrolidine dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1.	pyrrolidine dithiocarbamic acid	0-27	heme oxygenase 1	Rattus norvegicus	138-154
12773984-1	2003	BACKGROUND: Pyrrolidine dithiocarbamate (PDTC) represents a class of antioxidants and is a potent inducer of the heme oxygenase-1 (HO-1) gene and an inhibitor of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	12-39	heme oxygenase 1	Rattus norvegicus	113-129
12773984-1	2003	BACKGROUND: Pyrrolidine dithiocarbamate (PDTC) represents a class of antioxidants and is a potent inducer of the heme oxygenase-1 (HO-1) gene and an inhibitor of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	12-39	heme oxygenase 1	Rattus norvegicus	131-135
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	0-27	granzyme B	Mus musculus	268-278
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-106
12773984-1	2003	BACKGROUND: Pyrrolidine dithiocarbamate (PDTC) represents a class of antioxidants and is a potent inducer of the heme oxygenase-1 (HO-1) gene and an inhibitor of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	41-45	heme oxygenase 1	Rattus norvegicus	113-129
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	jun proto-oncogene	Mus musculus	111-115
12773984-1	2003	BACKGROUND: Pyrrolidine dithiocarbamate (PDTC) represents a class of antioxidants and is a potent inducer of the heme oxygenase-1 (HO-1) gene and an inhibitor of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	41-45	heme oxygenase 1	Rattus norvegicus	131-135
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	interleukin 2	Mus musculus	156-160
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	interleukin 2	Mus musculus	215-219
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	granzyme A	Mus musculus	252-262
12700414-5	2003	Pyrrolidine dithiocarbamate (PDTC) and N-tosyl-L-phenylalanine chloromethyl ketone (TPCK) blocked NFkappaB and AP-1 binding activity in nuclear extracts of IL-2-stimulated NK cells in an EMSA and also inhibited the IL-2-induced expression of perforin, granzyme A, and granzyme B gene expression in enriched NK cells.	pyrrolidine dithiocarbamic acid	29-33	granzyme B	Mus musculus	268-278
12684049-5	2003	Dexamethasone (1 microM) and pyrrolidine dithiocarbamate (PDTC, 100 microM), which inhibit activation of NFkappaB, prevented the increases in GDNF mRNA by H(2)O(2).	pyrrolidine dithiocarbamic acid	29-56	glial cell derived neurotrophic factor	Rattus norvegicus	142-146
12684049-5	2003	Dexamethasone (1 microM) and pyrrolidine dithiocarbamate (PDTC, 100 microM), which inhibit activation of NFkappaB, prevented the increases in GDNF mRNA by H(2)O(2).	pyrrolidine dithiocarbamic acid	58-62	glial cell derived neurotrophic factor	Rattus norvegicus	142-146
12670494-3	2003	Elevation of ET-1 expression in response to oleic acid was inhibited by the protein kinase C (PKC) inhibitor, GF109203X, or the NF-kappa B inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	150-177	endothelin 1	Homo sapiens	13-17
12670494-3	2003	Elevation of ET-1 expression in response to oleic acid was inhibited by the protein kinase C (PKC) inhibitor, GF109203X, or the NF-kappa B inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor kappa B subunit 1	Homo sapiens	128-138
12642397-6	2003	(3) The ubiquitin/proteosome inhibitors, MG132 (10 micro M) and pyrrolidine dithiocarbamate (200 micro M), suppressed activation of NF-kappaB as well as stimulation of fractalkine mRNA and protein expression by TNF-alpha.	pyrrolidine dithiocarbamic acid	64-91	C-X3-C motif chemokine ligand 1	Rattus norvegicus	168-179
12660227-3	2003	Hypoxia/reoxygenation strongly activated nuclear factor-kappaB (NF-kappaB) in synovial fibroblasts to the levels produced by phorbol 12-myristate 13-acetate and caused lymphocyte hyperadhesiveness to synovial fibroblasts as well as up-regulation of ICAM-1, both of which were completely blocked by a NF-kappaB antagonist (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	322-349	nuclear factor kappa B subunit 1	Homo sapiens	41-62
12660227-3	2003	Hypoxia/reoxygenation strongly activated nuclear factor-kappaB (NF-kappaB) in synovial fibroblasts to the levels produced by phorbol 12-myristate 13-acetate and caused lymphocyte hyperadhesiveness to synovial fibroblasts as well as up-regulation of ICAM-1, both of which were completely blocked by a NF-kappaB antagonist (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	322-349	nuclear factor kappa B subunit 1	Homo sapiens	64-73
12642397-6	2003	(3) The ubiquitin/proteosome inhibitors, MG132 (10 micro M) and pyrrolidine dithiocarbamate (200 micro M), suppressed activation of NF-kappaB as well as stimulation of fractalkine mRNA and protein expression by TNF-alpha.	pyrrolidine dithiocarbamic acid	64-91	tumor necrosis factor	Rattus norvegicus	211-220
12584727-0	2003	Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells.	pyrrolidine dithiocarbamic acid	0-27	AKT serine/threonine kinase 1	Homo sapiens	71-74
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	48-74	interleukin 1 beta	Mus musculus	107-115
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	48-74	tumor necrosis factor	Mus musculus	120-129
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	76-80	interleukin 1 beta	Mus musculus	107-115
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	76-80	tumor necrosis factor	Mus musculus	120-129
12584727-0	2003	Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 8	Homo sapiens	93-116
12618706-7	2003	NFkappaB activity was inhibited by either prior transduction of RASMCs with mutant IkappaB or treatment with pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	109-136	nuclear factor kappa B subunit 1	Homo sapiens	0-8
12618706-12	2003	Inhibition of NFkappaB activity by either pyrrolidine dithiocarbamate treatment or mutant IkappaB transduction abrogated NO-induced enhancement of TF mRNA and functional activity.	pyrrolidine dithiocarbamic acid	42-69	nuclear factor kappa B subunit 1	Homo sapiens	14-22
12618706-12	2003	Inhibition of NFkappaB activity by either pyrrolidine dithiocarbamate treatment or mutant IkappaB transduction abrogated NO-induced enhancement of TF mRNA and functional activity.	pyrrolidine dithiocarbamic acid	42-69	coagulation factor III, tissue factor	Homo sapiens	147-149
12540607-10	2003	Blocking of NF-kappaB activation in cytokine-exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased IL-1beta-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	147-174	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	12-21
12576442-8	2003	All six anti-inflammatory agents suppressed induction of IL-8 mRNA expression in lung cancer cells by >90%, four (pentoxifylline, celecoxib, pyrrolidine dithiocarbamate, and dexamethasone) having a dose-dependent effect.	pyrrolidine dithiocarbamic acid	144-171	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12540607-10	2003	Blocking of NF-kappaB activation in cytokine-exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased IL-1beta-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	147-174	interleukin 1 beta	Rattus norvegicus	185-193
12540607-10	2003	Blocking of NF-kappaB activation in cytokine-exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased IL-1beta-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	147-174	C-C motif chemokine ligand 2	Rattus norvegicus	202-207
12574204-5	2003	This effect on NF-kappa B binding was blocked in the presence of the NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	15-25
12574204-5	2003	This effect on NF-kappa B binding was blocked in the presence of the NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	69-79
12574204-5	2003	This effect on NF-kappa B binding was blocked in the presence of the NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	120-124	nuclear factor kappa B subunit 1	Homo sapiens	15-25
12574204-5	2003	This effect on NF-kappa B binding was blocked in the presence of the NF-kappa B inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	120-124	nuclear factor kappa B subunit 1	Homo sapiens	69-79
12588890-7	2003	NF-kappaB activation and IL-8 secretion were attenuated by the NF-kappaB inhibitors pyrrolidine dithiocarbamate and cell-permeable peptide.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	0-9
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	52-60
12588890-7	2003	NF-kappaB activation and IL-8 secretion were attenuated by the NF-kappaB inhibitors pyrrolidine dithiocarbamate and cell-permeable peptide.	pyrrolidine dithiocarbamic acid	84-111	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12588890-7	2003	NF-kappaB activation and IL-8 secretion were attenuated by the NF-kappaB inhibitors pyrrolidine dithiocarbamate and cell-permeable peptide.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	63-72
12509805-3	2003	Cytokine-induced increases in nitrite accumulation (an index of NO production) and iNOS expression were attenuated by inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	147-174	nitric oxide synthase 2	Rattus norvegicus	83-87
12509805-3	2003	Cytokine-induced increases in nitrite accumulation (an index of NO production) and iNOS expression were attenuated by inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	176-180	nitric oxide synthase 2	Rattus norvegicus	83-87
12505195-0	2003	Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	36-45
12505195-0	2003	Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells.	pyrrolidine dithiocarbamic acid	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	96-122	interleukin 1 beta	Homo sapiens	133-141
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	96-122	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	124-128	nuclear factor kappa B subunit 1	Homo sapiens	81-90
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	124-128	interleukin 1 beta	Homo sapiens	133-141
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	0-27	superoxide dismutase 2	Homo sapiens	119-124
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	0-27	superoxide dismutase 2	Homo sapiens	167-172
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 alpha	Homo sapiens	176-180
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	52-60
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	29-33	superoxide dismutase 2	Homo sapiens	119-124
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	29-33	superoxide dismutase 2	Homo sapiens	167-172
14515147-5	2003	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kappaB.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 alpha	Homo sapiens	176-180
12506055-14	2003	Preincubation of cells with 10(-7) M pyrrolidinedithiocarbamate (PDTC), an inhibitor of nuclear factor (NF)-kappaB, abolished the increase in MMP-2 activity and protein expression induced by E(2) at 10(-10) M. CONCLUSIONS: Both ER subtypes are expressed in RPE and regulated in a dose-dependent fashion by E(2).	pyrrolidine dithiocarbamic acid	37-63	matrix metallopeptidase 2	Homo sapiens	142-147
12388243-3	2003	Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	22-49	interleukin 4	Homo sapiens	109-113
12388243-3	2003	Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	22-49	C-C motif chemokine ligand 2	Homo sapiens	122-127
12388243-3	2003	Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	51-55	interleukin 4	Homo sapiens	109-113
12388243-3	2003	Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	51-55	C-C motif chemokine ligand 2	Homo sapiens	122-127
12506055-14	2003	Preincubation of cells with 10(-7) M pyrrolidinedithiocarbamate (PDTC), an inhibitor of nuclear factor (NF)-kappaB, abolished the increase in MMP-2 activity and protein expression induced by E(2) at 10(-10) M. CONCLUSIONS: Both ER subtypes are expressed in RPE and regulated in a dose-dependent fashion by E(2).	pyrrolidine dithiocarbamic acid	65-69	matrix metallopeptidase 2	Homo sapiens	142-147
12183568-7	2002	C. neoformans plus 18B7 also induced degradation of I-kappaBalpha, and MIP-1alpha release was suppressed by the antioxidant NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	144-171	chemokine (C-C motif) ligand 3	Mus musculus	71-81
12482581-6	2002	All antioxidants up-regulate Erk1/2, while only hydroxytyrosol and pyrrolidine dithiocarbamate activate c-Jun N-terminal kinase (JNK).	pyrrolidine dithiocarbamic acid	67-94	mitogen-activated protein kinase 8	Homo sapiens	104-127
12482581-6	2002	All antioxidants up-regulate Erk1/2, while only hydroxytyrosol and pyrrolidine dithiocarbamate activate c-Jun N-terminal kinase (JNK).	pyrrolidine dithiocarbamic acid	67-94	mitogen-activated protein kinase 8	Homo sapiens	129-132
12482581-8	2002	Bcl-2 phosphorylation was increased by hydroxytyrosol and pyrrolidine dithiocarbamate and not by resveratrol.	pyrrolidine dithiocarbamic acid	58-85	BCL2 apoptosis regulator	Homo sapiens	0-5
12573143-9	2002	The antioxidant, pyrrolidine dithiocarbamate, reduced TNF-induced, but not the constitutive, NF-kappaB activation.	pyrrolidine dithiocarbamic acid	17-44	tumor necrosis factor	Homo sapiens	54-57
12482504-7	2002	The selective inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly blocked HIF-1 protein expression.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	27-36
12482504-7	2002	The selective inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly blocked HIF-1 protein expression.	pyrrolidine dithiocarbamic acid	38-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
12482504-7	2002	The selective inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly blocked HIF-1 protein expression.	pyrrolidine dithiocarbamic acid	67-71	nuclear factor kappa B subunit 1	Homo sapiens	27-36
12482504-7	2002	The selective inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly blocked HIF-1 protein expression.	pyrrolidine dithiocarbamic acid	67-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
12635866-6	2002	Pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB) prevented the elevation of TNF-alpha mRNA levels induced by low-Mg2+ medium without LPS-stimulation, but had no suppressive effect on IL-1beta mRNA levels.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	83-92
12387820-0	2002	Pyrrolidine dithiocarbamate induces cyclooxygenase-2 expression in NIH 3T3 fibroblast cells.	pyrrolidine dithiocarbamic acid	0-27	prostaglandin-endoperoxide synthase 2	Mus musculus	36-52
12387820-8	2002	In addition, pretreatment of N-acetyl-L-cystein or dithiothreitol, other antioxidants, inhibited the PDTC-induced COX-2 expression.	pyrrolidine dithiocarbamic acid	101-105	prostaglandin-endoperoxide synthase 2	Mus musculus	114-119
12241998-4	2002	The increased production of NO from rIFN-gamma plus IXD-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	127-154	interferon gamma	Rattus norvegicus	36-46
12241998-4	2002	The increased production of NO from rIFN-gamma plus IXD-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	156-160	interferon gamma	Rattus norvegicus	36-46
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	0-27	integrin subunit alpha L	Homo sapiens	75-80
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	0-27	integrin subunit alpha L	Homo sapiens	81-91
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	0-27	X-linked Kx blood group	Homo sapiens	150-153
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	29-33	integrin subunit alpha L	Homo sapiens	75-80
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	29-33	integrin subunit alpha L	Homo sapiens	81-91
12163056-5	2002	Pyrrolidine dithiocarbamate (PDTC) also suppressed the level of expression CD11a/LFA-1alpha protein, although the effect of PDTC was less potent than NAC.	pyrrolidine dithiocarbamic acid	29-33	X-linked Kx blood group	Homo sapiens	150-153
12230105-5	2002	The increased production of NO and TNF-alpha from rIFN-gamma-plus OD-stimulated cells was almost completely inhibited by pretreatment with 100 microM of pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	153-180	interferon gamma	Rattus norvegicus	50-60
12230105-5	2002	The increased production of NO and TNF-alpha from rIFN-gamma-plus OD-stimulated cells was almost completely inhibited by pretreatment with 100 microM of pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	182-186	interferon gamma	Rattus norvegicus	50-60
12208776-10	2002	In contrast to dexamethasone, addition of the NF-kappaB inhibitors pyrrolidine dithiocarbamate (PDTC) and n-tosyl-l-phenylalanine chloromethyl ketone (TPCK) completely abolished cytokine and chemokine production.	pyrrolidine dithiocarbamic acid	67-94	nuclear factor kappa B subunit 1	Homo sapiens	46-55
12208776-10	2002	In contrast to dexamethasone, addition of the NF-kappaB inhibitors pyrrolidine dithiocarbamate (PDTC) and n-tosyl-l-phenylalanine chloromethyl ketone (TPCK) completely abolished cytokine and chemokine production.	pyrrolidine dithiocarbamic acid	96-100	nuclear factor kappa B subunit 1	Homo sapiens	46-55
12453435-0	2002	The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells.	pyrrolidine dithiocarbamic acid	29-56	interleukin 1 beta	Mus musculus	66-83
12453435-0	2002	The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells.	pyrrolidine dithiocarbamic acid	29-56	prostaglandin-endoperoxide synthase 2	Mus musculus	92-108
12530505-5	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an anti-oxidant, inhibited the CPT-induced uPA mRNA expression.	pyrrolidine dithiocarbamic acid	18-45	plasminogen activator, urokinase	Homo sapiens	97-100
12530505-5	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an anti-oxidant, inhibited the CPT-induced uPA mRNA expression.	pyrrolidine dithiocarbamic acid	47-51	plasminogen activator, urokinase	Homo sapiens	97-100
12237255-9	2002	4 Antioxidants (pyrrolidine dithiocarbamate and N-acetyl-L-cysteine) inhibited GPI-80 release by TNF-alpha stimulation, but superoxide dismutase did not.	pyrrolidine dithiocarbamic acid	16-43	vanin 2	Homo sapiens	79-85
12237255-9	2002	4 Antioxidants (pyrrolidine dithiocarbamate and N-acetyl-L-cysteine) inhibited GPI-80 release by TNF-alpha stimulation, but superoxide dismutase did not.	pyrrolidine dithiocarbamic acid	16-43	tumor necrosis factor	Homo sapiens	97-106
12244182-8	2002	Pyrrolidine dithiocarbamate, an antioxidant, inhibited the activation of NF-kappaB and significantly diminished the MAC-induced chemotaxis, concurrently lowering the levels of monocyte chemotactic protein-1 and MIP-1beta.	pyrrolidine dithiocarbamic acid	0-27	C-C motif chemokine ligand 2	Homo sapiens	176-206
12183568-7	2002	C. neoformans plus 18B7 also induced degradation of I-kappaBalpha, and MIP-1alpha release was suppressed by the antioxidant NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	144-171	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
12498315-12	2002	IL-1beta induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, both of which were abolished in the presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear factor-kappaB activation.	pyrrolidine dithiocarbamic acid	153-180	intercellular adhesion molecule 1	Rattus norvegicus	31-64
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	pyrrolidine dithiocarbamic acid	263-290	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-112
12230110-4	2002	TNF-alpha and IL-1beta expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-alpha and IL-1beta induction and reduced the IL-6 mRNA levels induced by PCB.	pyrrolidine dithiocarbamic acid	263-290	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
12230110-7	2002	However, pre-treating them with a NF-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed PCB-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	63-90	nuclear factor kappa B subunit 1	Homo sapiens	34-43
12230110-7	2002	However, pre-treating them with a NF-kappaB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed PCB-induced NF-kappaB activation.	pyrrolidine dithiocarbamic acid	63-90	nuclear factor kappa B subunit 1	Homo sapiens	115-124
12349897-9	2002	The COX-2-NFKB DNA-protein complex disappeared after treatment with pyrrolidine dithiocarbamate (PDTC; an antioxidant) or herbimycin A (a tyrosine kinase inhibitor).	pyrrolidine dithiocarbamic acid	68-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	4-9
12349897-9	2002	The COX-2-NFKB DNA-protein complex disappeared after treatment with pyrrolidine dithiocarbamate (PDTC; an antioxidant) or herbimycin A (a tyrosine kinase inhibitor).	pyrrolidine dithiocarbamic acid	97-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	4-9
12349897-10	2002	PDTC and herbimycin A attenuated TNF-alpha-stimulated PGE2 release.	pyrrolidine dithiocarbamic acid	0-4	tumor necrosis factor	Homo sapiens	33-42
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	53-80	interleukin 1 beta	Homo sapiens	119-127
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	53-80	NFKB inhibitor alpha	Homo sapiens	151-164
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	82-86	interleukin 1 beta	Homo sapiens	119-127
12356282-6	2002	Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.	pyrrolidine dithiocarbamic acid	82-86	NFKB inhibitor alpha	Homo sapiens	151-164
12498315-12	2002	IL-1beta induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, both of which were abolished in the presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear factor-kappaB activation.	pyrrolidine dithiocarbamic acid	153-180	interleukin 1 beta	Rattus norvegicus	0-8
12498315-12	2002	IL-1beta induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, both of which were abolished in the presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear factor-kappaB activation.	pyrrolidine dithiocarbamic acid	153-180	C-C motif chemokine ligand 2	Rattus norvegicus	69-103
12104094-8	2002	Nuclear factor-kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate was able to completely inhibit the production of NO and TNF-alpha.	pyrrolidine dithiocarbamic acid	47-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-22
11964141-0	2002	Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells.	pyrrolidine dithiocarbamic acid	30-57	tumor protein p53	Homo sapiens	107-110
12151344-0	2002	Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	127-154	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12151344-0	2002	Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	127-154	heme oxygenase 1	Homo sapiens	29-45
12151344-0	2002	Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	127-154	vascular endothelial growth factor A	Homo sapiens	50-84
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	20-47	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	20-47	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12104094-8	2002	Nuclear factor-kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate was able to completely inhibit the production of NO and TNF-alpha.	pyrrolidine dithiocarbamic acid	47-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-34
12104094-8	2002	Nuclear factor-kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate was able to completely inhibit the production of NO and TNF-alpha.	pyrrolidine dithiocarbamic acid	47-74	tumor necrosis factor	Mus musculus	131-140
12067898-6	2002	Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	50-77	C-C motif chemokine ligand 2	Homo sapiens	88-93
12006557-3	2002	IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants such as superoxide dismutase, catalase, pyrrolidine dithiocarbamate, and N-acetylcysteine.	pyrrolidine dithiocarbamic acid	129-156	interferon gamma	Homo sapiens	0-9
12006557-3	2002	IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants such as superoxide dismutase, catalase, pyrrolidine dithiocarbamate, and N-acetylcysteine.	pyrrolidine dithiocarbamic acid	129-156	major histocompatibility complex, class II, DR alpha	Homo sapiens	18-25
12131776-14	2002	Inducible ICAM-1 expression was blocked by pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappa B activation, but not by inhibitors of mitogen-activated protein kinase pathways.	pyrrolidine dithiocarbamic acid	43-70	intercellular adhesion molecule 1	Rattus norvegicus	10-16
12067898-6	2002	Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	50-77	interleukin 6	Homo sapiens	104-108
12067898-6	2002	Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	50-77	nuclear factor kappa B subunit 1	Homo sapiens	208-217
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	C-C motif chemokine ligand 2	Homo sapiens	98-103
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	interleukin 6	Homo sapiens	114-118
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	intercellular adhesion molecule 1	Homo sapiens	123-129
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	nuclear factor kappa B subunit 1	Homo sapiens	228-249
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	nuclear factor kappa B subunit 1	Homo sapiens	251-260
12039983-6	2002	Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling.	pyrrolidine dithiocarbamic acid	60-87	C-C motif chemokine ligand 2	Homo sapiens	265-270
12008118-9	2002	Exposure of reoxygenating HMEC-1 to the antioxidant pyrrolidine dithiocarbamate produced complete abrogation of NFkappaB activation and the intensive PMN adhesion observed in untreated, posthypoxic HMEC-1.	pyrrolidine dithiocarbamic acid	52-79	nuclear factor kappa B subunit 1	Homo sapiens	112-120
12009331-8	2002	NF-kappaB inhibitor, pyrrolidine dithiocarbamate yielded 83-84% reduction of MMP-3 and 38-55% for MMP-13 in human chondrocytes.	pyrrolidine dithiocarbamic acid	21-48	matrix metallopeptidase 3	Homo sapiens	77-82
12126654-0	2002	Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes.	pyrrolidine dithiocarbamic acid	78-105	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
11961005-7	2002	The contribution of H(2)O(2) in regulating NF-kappaB activation was evaluated by using the antioxidants dimethyl-thiourea and pyrrolidine dithiocarbamate in protein-overloaded HK-2 cells.	pyrrolidine dithiocarbamic acid	126-153	nuclear factor kappa B subunit 1	Homo sapiens	43-52
11880120-7	2002	The increased production of NO from rIFN-gamma plus EA-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	126-153	interferon gamma	Rattus norvegicus	36-46
11880120-7	2002	The increased production of NO from rIFN-gamma plus EA-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB).	pyrrolidine dithiocarbamic acid	155-159	interferon gamma	Rattus norvegicus	36-46
12009850-11	2002	AP-1 and/or NF-kappa B decoy oligonucleotides and pyrrolidine dithiocarbamate suppressed the iNOS induction, which confirmed involvement of AP-1 and NF-kappa B as transcription factors.	pyrrolidine dithiocarbamic acid	50-77	nitric oxide synthase 2	Bos taurus	93-97
11943425-9	2002	HB-EGF gene expression by tumor necrosis factor was accompanied by an increase in NF-B binding activity in NPC but not in hepatocytes in primary culture, which was abolished by pyrrolidine dithiocarbamate, an inhibitor of NF-B activation.	pyrrolidine dithiocarbamic acid	177-204	heparin-binding EGF-like growth factor	Rattus norvegicus	0-6
12009331-8	2002	NF-kappaB inhibitor, pyrrolidine dithiocarbamate yielded 83-84% reduction of MMP-3 and 38-55% for MMP-13 in human chondrocytes.	pyrrolidine dithiocarbamic acid	21-48	matrix metallopeptidase 13	Homo sapiens	98-104
11835400-8	2002	This induction was attenuated by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB.	pyrrolidine dithiocarbamic acid	33-60	nuclear factor kappa B subunit 1	Homo sapiens	85-93
11792699-9	2002	In the presence of the pyrrolidine dithiocarbamate, a potent antioxidant and inhibitor of NF-kappaB activity, etomoxir did not down-regulate PPARalpha mRNA in C2C12 skeletal muscle cells.	pyrrolidine dithiocarbamic acid	23-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
11834481-5	2002	Furthermore, inhibitors of NF-kappaB activation, such as lactacystin, MG132, and pyrrolidine dithiocarbamate, were found to completely block the production of TNF-alpha in response to LPS stimulation, indicating a requirement of NF-kappaB for TNF-alpha expression.	pyrrolidine dithiocarbamic acid	81-108	tumor necrosis factor	Homo sapiens	159-168
11834481-5	2002	Furthermore, inhibitors of NF-kappaB activation, such as lactacystin, MG132, and pyrrolidine dithiocarbamate, were found to completely block the production of TNF-alpha in response to LPS stimulation, indicating a requirement of NF-kappaB for TNF-alpha expression.	pyrrolidine dithiocarbamic acid	81-108	tumor necrosis factor	Homo sapiens	243-252
12160224-6	2002	Furthermore, pyrrolidine dithiocarbamate (PDTC) partially inhibited the IL-1alpha production and completely inhibited NF-kappaB expression by Pam 212 cells.	pyrrolidine dithiocarbamic acid	13-40	interleukin 1 alpha	Mus musculus	72-81
12160224-6	2002	Furthermore, pyrrolidine dithiocarbamate (PDTC) partially inhibited the IL-1alpha production and completely inhibited NF-kappaB expression by Pam 212 cells.	pyrrolidine dithiocarbamic acid	42-46	interleukin 1 alpha	Mus musculus	72-81
11809417-9	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of the redox sensitive transcription factor NF-kappa B, abrogated the increased expression of p53 protein in response to H(2)O(2), and enhanced cell survival.	pyrrolidine dithiocarbamic acid	18-45	nuclear factor kappa B subunit 1	Homo sapiens	111-121
11809417-9	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of the redox sensitive transcription factor NF-kappa B, abrogated the increased expression of p53 protein in response to H(2)O(2), and enhanced cell survival.	pyrrolidine dithiocarbamic acid	18-45	tumor protein p53	Homo sapiens	161-164
11809417-9	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of the redox sensitive transcription factor NF-kappa B, abrogated the increased expression of p53 protein in response to H(2)O(2), and enhanced cell survival.	pyrrolidine dithiocarbamic acid	47-51	nuclear factor kappa B subunit 1	Homo sapiens	111-121
11809417-9	2002	Pretreatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of the redox sensitive transcription factor NF-kappa B, abrogated the increased expression of p53 protein in response to H(2)O(2), and enhanced cell survival.	pyrrolidine dithiocarbamic acid	47-51	tumor protein p53	Homo sapiens	161-164
11858955-5	2002	The presence of N-acetyl-L-cysteine or pyrrolidine dithiocarbamate during H(2)O(2) treatment prevented the nuclear localization of NF-kappaB.	pyrrolidine dithiocarbamic acid	39-66	nuclear factor kappa B subunit 1	Homo sapiens	131-140
11928721-7	2002	Pretreatment with antioxidants, pyrrolidine dithiocarbamate and alpha-lipoic acid, both of which are known to be suppressors of NF-kappaB activation, effectively attenuated basal and TNF-alpha-induced ET-1 release.	pyrrolidine dithiocarbamic acid	32-59	nuclear factor kappa B subunit 1	Homo sapiens	128-137
11928721-7	2002	Pretreatment with antioxidants, pyrrolidine dithiocarbamate and alpha-lipoic acid, both of which are known to be suppressors of NF-kappaB activation, effectively attenuated basal and TNF-alpha-induced ET-1 release.	pyrrolidine dithiocarbamic acid	32-59	tumor necrosis factor	Homo sapiens	183-192
11928721-7	2002	Pretreatment with antioxidants, pyrrolidine dithiocarbamate and alpha-lipoic acid, both of which are known to be suppressors of NF-kappaB activation, effectively attenuated basal and TNF-alpha-induced ET-1 release.	pyrrolidine dithiocarbamic acid	32-59	endothelin 1	Homo sapiens	201-205
11755918-6	2002	In contrast, THP-1 macrophages when treated with pyrrolidine dithiocarbamate, an anti-oxidant and the selective inhibitor for nuclear factor kappaB, showed an enhanced 15d-PGJ2-mediated upregulation of IL-8 gene expression.	pyrrolidine dithiocarbamic acid	49-76	GLI family zinc finger 2	Homo sapiens	13-18
11755918-6	2002	In contrast, THP-1 macrophages when treated with pyrrolidine dithiocarbamate, an anti-oxidant and the selective inhibitor for nuclear factor kappaB, showed an enhanced 15d-PGJ2-mediated upregulation of IL-8 gene expression.	pyrrolidine dithiocarbamic acid	49-76	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	pyrrolidine dithiocarbamic acid	256-283	interleukin 1 alpha	Homo sapiens	43-47
12502184-2	2002	We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4.	pyrrolidine dithiocarbamic acid	256-283	signal transducer and activator of transcription 3	Homo sapiens	51-55
11835400-8	2002	This induction was attenuated by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkappaB.	pyrrolidine dithiocarbamic acid	62-66	nuclear factor kappa B subunit 1	Homo sapiens	85-93
11704541-4	2001	Increased expression of MMP-9 and NF-kappa B activation induced by TNF-alpha were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin.	pyrrolidine dithiocarbamic acid	95-122	matrix metallopeptidase 9	Homo sapiens	24-29
11679590-9	2001	Surprisingly, the antioxidant and NF-kappa B inhibitor pyrrolidine dithiocarbamate blocked doxorubicin-induced NF-kappa B transcriptional activation and provided profound protection against doxorubicin killing.	pyrrolidine dithiocarbamic acid	55-82	nuclear factor kappa B subunit 1	Homo sapiens	34-44
11679590-9	2001	Surprisingly, the antioxidant and NF-kappa B inhibitor pyrrolidine dithiocarbamate blocked doxorubicin-induced NF-kappa B transcriptional activation and provided profound protection against doxorubicin killing.	pyrrolidine dithiocarbamic acid	55-82	nuclear factor kappa B subunit 1	Homo sapiens	111-121
11704541-4	2001	Increased expression of MMP-9 and NF-kappa B activation induced by TNF-alpha were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin.	pyrrolidine dithiocarbamic acid	95-122	nuclear factor kappa B subunit 1	Homo sapiens	34-44
11704541-4	2001	Increased expression of MMP-9 and NF-kappa B activation induced by TNF-alpha were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin.	pyrrolidine dithiocarbamic acid	95-122	tumor necrosis factor	Homo sapiens	67-76
11813981-7	2001	Other thiol-antioxidants, such as 2-mercaptoethanol, pyrrolidine dithiocarbamate, and glutathione, showed similar effect to NAC on CD21 expression.	pyrrolidine dithiocarbamic acid	53-80	complement C3d receptor 2	Homo sapiens	131-135
11811521-10	2001	In PBMCs and Jurkat T cells (subclones JR and JE6.1), this activation could be inhibited by pre-treatment with the antioxidants, pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC).	pyrrolidine dithiocarbamic acid	129-156	X-linked Kx blood group	Homo sapiens	189-192
11811521-10	2001	In PBMCs and Jurkat T cells (subclones JR and JE6.1), this activation could be inhibited by pre-treatment with the antioxidants, pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC).	pyrrolidine dithiocarbamic acid	158-162	X-linked Kx blood group	Homo sapiens	189-192
11701459-0	2001	Induction of nuclear orphan receptor NGFI-B gene and apoptosis in rat vascular smooth muscle cells treated with pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	112-138	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	37-43
11903618-4	2001	Pyrrolidinedithiocarbamate (PDTC) inhibits nitrite production, with a half maximal inhibitory concentration (IC50) of 19.3 micromol/L and the iNOS protein expression in FSDC.	pyrrolidine dithiocarbamic acid	0-26	nitric oxide synthase 2	Homo sapiens	142-146
11903618-4	2001	Pyrrolidinedithiocarbamate (PDTC) inhibits nitrite production, with a half maximal inhibitory concentration (IC50) of 19.3 micromol/L and the iNOS protein expression in FSDC.	pyrrolidine dithiocarbamic acid	28-32	nitric oxide synthase 2	Homo sapiens	142-146
11578809-4	2001	Pyrrolidine dithiocarbamate (PDTC) was cytotoxic on its own and inhibited NF-kappaB activity.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
11578809-4	2001	Pyrrolidine dithiocarbamate (PDTC) was cytotoxic on its own and inhibited NF-kappaB activity.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
11578809-7	2001	Our results show that NO, taxol and PDTC induced apoptosis and NF-kappaB inhibition in leukemic cells but their cytotoxicity either alone or in combination, does not seem to be dependent on the inhibition of NF-KB activity.	pyrrolidine dithiocarbamic acid	36-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
11701459-7	2001	Under low VSMC density, PDTC-induced expression of NGFI-B mRNA was correlated with the magnitude of apoptosis, which was quantified by enzyme immunoassay for histone-associated DNA fragments.	pyrrolidine dithiocarbamic acid	24-28	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	51-57
11699074-3	2001	In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression.	pyrrolidine dithiocarbamic acid	68-95	tumor necrosis factor	Homo sapiens	137-164
12031258-8	2001	Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	65-92	C-C motif chemokine ligand 2	Homo sapiens	160-165
12031258-8	2001	Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression.	pyrrolidine dithiocarbamic acid	94-98	C-C motif chemokine ligand 2	Homo sapiens	160-165
11598079-7	2001	Pretreatment of Mono Mac 6 with the antioxidant and NF-kappaB inhibitor PDTC (pyrrolidine dithiocarbamate) induced activation of caspase-3 and led to apoptotic cell death.	pyrrolidine dithiocarbamic acid	78-105	nuclear factor kappa B subunit 1	Homo sapiens	52-61
11699074-3	2001	In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression.	pyrrolidine dithiocarbamic acid	68-95	tumor necrosis factor	Homo sapiens	166-175
11699074-3	2001	In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression.	pyrrolidine dithiocarbamic acid	97-101	tumor necrosis factor	Homo sapiens	137-164
11699074-3	2001	In the present studies, we evaluated the effect of the antioxidant, pyrrolidine dithiocarbamate (PDTC), on murine and human myeloid cell tumor necrosis factor alpha (TNF alpha) gene and protein expression.	pyrrolidine dithiocarbamic acid	97-101	tumor necrosis factor	Homo sapiens	166-175
11683522-1	2001	In this study we have investigated the relationship between neointima formation and NF-kappaB activation in a model of endothelial denudation of rat carotid artery (balloon angioplasty) using the antioxidant pyrrolidine dithiocarbamate as inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	208-235	nuclear factor kappa B subunit 1	Homo sapiens	84-93
11583958-12	2001	In vitro, treatment of cultured canine jugular vein endothelial cells with the reactive oxygen intermediate H2O2 induced a concentration-dependent increase in MCP-1 mRNA levels, which was inhibited by the antioxidant N-acetyl-L-cysteine, a precursor of glutathione, but not pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB and activator of AP-1.	pyrrolidine dithiocarbamic acid	274-301	C-C motif chemokine ligand 2	Canis lupus familiaris	159-164
11588108-8	2001	The PKC inhibitors (Go 6976, Ro 31-8220 and GF 109203X) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), also attenuated the LTA-induced increases in COX-2 expression and COX activity.	pyrrolidine dithiocarbamic acid	81-108	nuclear factor kappa B subunit 1	Homo sapiens	60-69
11588108-8	2001	The PKC inhibitors (Go 6976, Ro 31-8220 and GF 109203X) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), also attenuated the LTA-induced increases in COX-2 expression and COX activity.	pyrrolidine dithiocarbamic acid	110-114	nuclear factor kappa B subunit 1	Homo sapiens	60-69
11683522-5	2001	Treatment of rats for 14 days with the antioxidant agent pyrrolidine dithiocarbamate (50, 100, 200 mg/kg per os and day) caused a significant inhibition of all the parameters assayed, except beta-actin protein expression.	pyrrolidine dithiocarbamic acid	57-84	actin, beta	Rattus norvegicus	191-201
11683522-1	2001	In this study we have investigated the relationship between neointima formation and NF-kappaB activation in a model of endothelial denudation of rat carotid artery (balloon angioplasty) using the antioxidant pyrrolidine dithiocarbamate as inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	208-235	nuclear factor kappa B subunit 1	Homo sapiens	252-261
11494409-4	2001	The activation of transcription factor NF-kappaB was apparently required for AMB-induced iNOS mRNA expression, as the latter was abolished by NF-kappaB inhibitors: pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	164-191	nitric oxide synthase 2	Rattus norvegicus	89-93
11597171-8	2001	Cycloheximide (an inhibitor of protein synthesis), pyrrolidine dithiocarbamate (PDTC; an NF-kappa B inhibitor) and genistein (an inhibitor of tyrosine protein kinases) inhibited cytokine-induced NO production, while dexamethasone, diaminohydroxypyrimidine (DAHP; an inhibitor of tetrahydrobiopterin synthesis) and PD 98059 (p42/44 MAP kinase inhibitor) had no effect.	pyrrolidine dithiocarbamic acid	51-78	cyclin dependent kinase 20	Homo sapiens	324-327
11597171-8	2001	Cycloheximide (an inhibitor of protein synthesis), pyrrolidine dithiocarbamate (PDTC; an NF-kappa B inhibitor) and genistein (an inhibitor of tyrosine protein kinases) inhibited cytokine-induced NO production, while dexamethasone, diaminohydroxypyrimidine (DAHP; an inhibitor of tetrahydrobiopterin synthesis) and PD 98059 (p42/44 MAP kinase inhibitor) had no effect.	pyrrolidine dithiocarbamic acid	80-84	cyclin dependent kinase 20	Homo sapiens	324-327
11578593-9	2001	Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha.	pyrrolidine dithiocarbamic acid	15-42	tumor necrosis factor	Rattus norvegicus	257-266
11578593-9	2001	Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha.	pyrrolidine dithiocarbamic acid	15-42	interleukin 1 beta	Rattus norvegicus	271-288
11578593-9	2001	Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha.	pyrrolidine dithiocarbamic acid	15-42	C-X-C motif chemokine ligand 6	Rattus norvegicus	315-332
11578593-9	2001	Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha.	pyrrolidine dithiocarbamic acid	15-42	C-C motif chemokine ligand 20	Rattus norvegicus	350-361
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-99
11571584-6	2001	The Ad.CFTR-dependent increase of ICAM-1 mRNA was abolished by inhibitors of NF-kB, such as N-acetyl-L-cysteine, pyrrolidine dithiocarbamate, parthenolide and the synthetic peptide SN50.	pyrrolidine dithiocarbamic acid	113-140	CF transmembrane conductance regulator	Homo sapiens	7-11
11571584-6	2001	The Ad.CFTR-dependent increase of ICAM-1 mRNA was abolished by inhibitors of NF-kB, such as N-acetyl-L-cysteine, pyrrolidine dithiocarbamate, parthenolide and the synthetic peptide SN50.	pyrrolidine dithiocarbamic acid	113-140	intercellular adhesion molecule 1	Homo sapiens	34-40
11171565-6	2001	Likewise, the NF-kappaB inhibitors pyrrolidine dithiocarbamate and N-acetyl-L-cysteine inhibited CCK stimulation of NF-kappaB and intracellular trypsinogen activation.	pyrrolidine dithiocarbamic acid	35-62	cholecystokinin	Rattus norvegicus	97-100
11494050-5	2001	We also observed that TGF-beta-induced p38 activation was inhibited by PDTC, pyrrolidinedithiocarbamate, a known antioxidant, and DPI, diphenylene iodonium chloride, one of the known NADPH oxidase inhibitors.	pyrrolidine dithiocarbamic acid	77-103	transforming growth factor beta 1	Homo sapiens	22-30
11494050-5	2001	We also observed that TGF-beta-induced p38 activation was inhibited by PDTC, pyrrolidinedithiocarbamate, a known antioxidant, and DPI, diphenylene iodonium chloride, one of the known NADPH oxidase inhibitors.	pyrrolidine dithiocarbamic acid	77-103	mitogen-activated protein kinase 14	Homo sapiens	39-42
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	26-53	CCAAT/enhancer binding protein alpha	Rattus norvegicus	114-119
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	26-53	CCAAT/enhancer binding protein delta	Rattus norvegicus	170-181
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	26-53	PCNA clamp associated factor	Rattus norvegicus	201-204
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	26-53	CCAAT/enhancer binding protein alpha	Rattus norvegicus	170-175
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	55-59	CCAAT/enhancer binding protein alpha	Rattus norvegicus	114-119
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	55-59	CCAAT/enhancer binding protein delta	Rattus norvegicus	170-181
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	55-59	PCNA clamp associated factor	Rattus norvegicus	201-204
11429396-14	2001	Pretreatment of rats with pyrrolidine dithiocarbamate (PDTC) suppresses LPS-, but not PAF-, induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF-induced C/EBP complex.	pyrrolidine dithiocarbamic acid	55-59	CCAAT/enhancer binding protein alpha	Rattus norvegicus	170-175
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	120-129
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	16-43	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	45-49	nuclear factor kappa B subunit 1	Homo sapiens	120-129
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
11422781-9	2001	A potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate, prevented NF-kappaB activation by inhibition of IkappaB-alpha degradation and decreased LDH and MDA levels, suggesting that NF-kappaB might be a regulator in a genetic response to increase oxidative stress-induced hepatic injury.	pyrrolidine dithiocarbamic acid	30-57	NFKB inhibitor alpha	Rattus norvegicus	107-120
11353135-7	2001	GCL subunit induction in each cell line by pyrrolidine dithiocarbamate (PDTC), phenethyl isothiocyanate (PEITC), and beta-naphthoflavone (beta-NF) was examined by RNAse protection assays.	pyrrolidine dithiocarbamic acid	43-70	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-3
11353135-7	2001	GCL subunit induction in each cell line by pyrrolidine dithiocarbamate (PDTC), phenethyl isothiocyanate (PEITC), and beta-naphthoflavone (beta-NF) was examined by RNAse protection assays.	pyrrolidine dithiocarbamic acid	72-76	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-3
11342657-0	2001	Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	123-150	interferon gamma	Homo sapiens	52-61
11342657-2	2001	Antioxidants can modulate the expression of immune and inflammatory genes, and pyrrolidine dithiocarbamate (PDTC) is a frequently used antioxidant to inhibit the transcription factor NF-kappaB.	pyrrolidine dithiocarbamic acid	79-106	nuclear factor kappa B subunit 1	Homo sapiens	183-192
11342657-2	2001	Antioxidants can modulate the expression of immune and inflammatory genes, and pyrrolidine dithiocarbamate (PDTC) is a frequently used antioxidant to inhibit the transcription factor NF-kappaB.	pyrrolidine dithiocarbamic acid	108-112	nuclear factor kappa B subunit 1	Homo sapiens	183-192
11342657-6	2001	Similar to PDTC, the heme biosynthesis inhibitor succinylacetone (SA) and the iron-chelator pyridoxal isonicotinoyl hydrazone inhibited cellular IDO activity without affecting protein expression, whereas addition of hemin or the heme precursor delta-aminolevulinic acid increased IDO activity.	pyrrolidine dithiocarbamic acid	11-15	indoleamine 2,3-dioxygenase 1	Homo sapiens	145-148
11278608-3	2001	Initially, T84 cells were pretreated with the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	66-93	nuclear factor kappa B subunit 1	Homo sapiens	46-55
11292690-4	2001	Actinomycin D and pyrrolidine dithiocarbamate inhibition of gene transcription and NF-kappa B activation, respectively, blocks LPS- and PGN-elevated TLR2 mRNA in monocytic cells.	pyrrolidine dithiocarbamic acid	18-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-93
11292690-4	2001	Actinomycin D and pyrrolidine dithiocarbamate inhibition of gene transcription and NF-kappa B activation, respectively, blocks LPS- and PGN-elevated TLR2 mRNA in monocytic cells.	pyrrolidine dithiocarbamic acid	18-45	toll-like receptor 4	Mus musculus	127-130
11292690-4	2001	Actinomycin D and pyrrolidine dithiocarbamate inhibition of gene transcription and NF-kappa B activation, respectively, blocks LPS- and PGN-elevated TLR2 mRNA in monocytic cells.	pyrrolidine dithiocarbamic acid	18-45	toll-like receptor 2	Mus musculus	149-153
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	pyrrolidine dithiocarbamic acid	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Homo sapiens	122-130
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Homo sapiens	132-141
11114294-5	2001	Its action was inhibited by inhibitors of the NF-kappaB pathway, including N-acetyl-l-cysteine, pyrrolidine dithiocarbamate, and a synthetic cell-permeable peptide containing the NF-kappaB nuclear localization signal sequence.	pyrrolidine dithiocarbamic acid	96-123	nuclear factor kappa B subunit 1	Homo sapiens	46-55
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	123-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	192-201
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-99
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
11526540-5	2001	LMW-HA-induced hepatoprotection could be neutralized by pretreatment with the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), demonstrating the involvement of NF-kappaB in the observed protective mechanism.	pyrrolidine dithiocarbamic acid	152-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	192-201
11463759-3	2001	To study the relation between hypoxia-induced cell death and activation of nuclear factor-kappaB (NF-kappaB) in a hypoxic state, we evaluated the effect of 2 antioxidant drugs, probucol and pyrrolidine dithiocarbamate (PDTC), on human endothelial apoptosis.	pyrrolidine dithiocarbamic acid	190-217	nuclear factor kappa B subunit 1	Homo sapiens	98-107
11463759-3	2001	To study the relation between hypoxia-induced cell death and activation of nuclear factor-kappaB (NF-kappaB) in a hypoxic state, we evaluated the effect of 2 antioxidant drugs, probucol and pyrrolidine dithiocarbamate (PDTC), on human endothelial apoptosis.	pyrrolidine dithiocarbamic acid	219-223	nuclear factor kappa B subunit 1	Homo sapiens	75-96
11463759-3	2001	To study the relation between hypoxia-induced cell death and activation of nuclear factor-kappaB (NF-kappaB) in a hypoxic state, we evaluated the effect of 2 antioxidant drugs, probucol and pyrrolidine dithiocarbamate (PDTC), on human endothelial apoptosis.	pyrrolidine dithiocarbamic acid	219-223	nuclear factor kappa B subunit 1	Homo sapiens	98-107
11390505-6	2001	Antioxidants N-acetylcysteine and pyrrolidine dithiocarbamate inhibited MMP production by AMs from SP-D(-/-) mice.	pyrrolidine dithiocarbamic acid	34-61	surfactant associated protein D	Mus musculus	99-103
11375274-6	2001	Thrombin-mediated upregulation of IGF-1R mRNA and protein levels was protein kinase C independent but was completely inhibited by the protein tyrosine kinase inhibitor genistein and by the antioxidants N-acetyl-L-cysteine and pyrrolidinedithiocarbamate, suggesting the involvement of reactive oxygen species.	pyrrolidine dithiocarbamic acid	226-252	coagulation factor II	Rattus norvegicus	0-8
11375274-6	2001	Thrombin-mediated upregulation of IGF-1R mRNA and protein levels was protein kinase C independent but was completely inhibited by the protein tyrosine kinase inhibitor genistein and by the antioxidants N-acetyl-L-cysteine and pyrrolidinedithiocarbamate, suggesting the involvement of reactive oxygen species.	pyrrolidine dithiocarbamic acid	226-252	insulin-like growth factor 1 receptor	Rattus norvegicus	34-40
11277268-4	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC), which also inhibits the titanium particle suppression of collagen, abrogated the titanium particle activation of NF-kappaB, suggesting the involvement of redox signals in NF-kappaB-mediated collagen gene expression.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	165-174
11342654-6	2001	Pretreatment with pyrrolidine dithiocarbamate or sulfasalazine attenuated the iNOS-dependent production of NO in the lung and restored the normal up-regulation of alveolar fluid clearance by catecholamines after prolonged hemorrhagic shock.	pyrrolidine dithiocarbamic acid	18-45	nitric oxide synthase 2	Rattus norvegicus	78-82
11282781-4	2001	An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38 MAPK inhibitor, blocked the IL-1beta-induced H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta.	pyrrolidine dithiocarbamic acid	38-65	interleukin 1 beta	Homo sapiens	105-113
11277268-4	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC), which also inhibits the titanium particle suppression of collagen, abrogated the titanium particle activation of NF-kappaB, suggesting the involvement of redox signals in NF-kappaB-mediated collagen gene expression.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	168-174
11277268-4	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC), which also inhibits the titanium particle suppression of collagen, abrogated the titanium particle activation of NF-kappaB, suggesting the involvement of redox signals in NF-kappaB-mediated collagen gene expression.	pyrrolidine dithiocarbamic acid	45-49	nuclear factor kappa B subunit 1	Homo sapiens	165-174
11277268-4	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC), which also inhibits the titanium particle suppression of collagen, abrogated the titanium particle activation of NF-kappaB, suggesting the involvement of redox signals in NF-kappaB-mediated collagen gene expression.	pyrrolidine dithiocarbamic acid	45-49	nuclear factor kappa B subunit 1	Homo sapiens	168-174
11360927-3	2001	Thus, we explored the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor-kappaB (NF-kappaB) in serum-exposed condition, on the activation of mitogen activated protein kinase (MAPK), especially, JNK/SAPK and p38 MAPK induction.	pyrrolidine dithiocarbamic acid	32-59	mitogen-activated protein kinase 8	Homo sapiens	244-247
11264769-13	2001	An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	30-57	nuclear factor kappa B subunit 1	Homo sapiens	17-26
11264769-13	2001	An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	30-57	interleukin 1 beta	Homo sapiens	69-77
11264769-13	2001	An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	30-57	tumor necrosis factor	Homo sapiens	82-91
11181056-0	2001	Activation of heat shock factor 1 by pyrrolidine dithiocarbamate is mediated by its activities as pro-oxidant and thiol modulator.	pyrrolidine dithiocarbamic acid	37-64	heat shock transcription factor 1	Homo sapiens	14-33
11181056-1	2001	Pyrrolidine dithiocarbamate (PDTC) is known to inhibit NF-kappa B, which plays a critical role(s) as an immediate early mediator of immune and inflammatory responses.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	55-65
11181056-1	2001	Pyrrolidine dithiocarbamate (PDTC) is known to inhibit NF-kappa B, which plays a critical role(s) as an immediate early mediator of immune and inflammatory responses.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	55-65
11181056-6	2001	In addition, PDTC-induced activation of HSF1 was significantly inhibited by NAC and a thiol-reducing agent dithiothreitol (DTT), while it was partially prevented by other antioxidants, AA, BHT, and PG.	pyrrolidine dithiocarbamic acid	13-17	heat shock transcription factor 1	Homo sapiens	40-44
11181056-6	2001	In addition, PDTC-induced activation of HSF1 was significantly inhibited by NAC and a thiol-reducing agent dithiothreitol (DTT), while it was partially prevented by other antioxidants, AA, BHT, and PG.	pyrrolidine dithiocarbamic acid	13-17	X-linked Kx blood group	Homo sapiens	76-79
11302181-2	2001	This iNOS increase was blocked by pyrrolidinedithiocarbamate (an inhibitor of iNOS induction) but it did not suppress the hyperpermeability response.	pyrrolidine dithiocarbamic acid	34-60	nitric oxide synthase 2	Homo sapiens	5-9
11302181-2	2001	This iNOS increase was blocked by pyrrolidinedithiocarbamate (an inhibitor of iNOS induction) but it did not suppress the hyperpermeability response.	pyrrolidine dithiocarbamic acid	34-60	nitric oxide synthase 2	Homo sapiens	78-82
11313716-4	2001	Pyrrolidine dithiocarbamate (PDTC) and N-alpha-para-tosyl-L-lysine chloromethyl ketone (TLCK), two inhibitors of NF-kappaB activation, showed the same effects of both NO-generating compounds.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
11223159-7	2001	The increases in RANTES mRNA and protein expression were suppressed by the NF-kappaB inhibitors gliotoxin, isohelenin, and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	123-150	C-C motif chemokine ligand 5	Homo sapiens	17-23
11223159-7	2001	The increases in RANTES mRNA and protein expression were suppressed by the NF-kappaB inhibitors gliotoxin, isohelenin, and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	123-150	nuclear factor kappa B subunit 1	Homo sapiens	75-84
11223159-7	2001	The increases in RANTES mRNA and protein expression were suppressed by the NF-kappaB inhibitors gliotoxin, isohelenin, and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	152-156	C-C motif chemokine ligand 5	Homo sapiens	17-23
11223159-7	2001	The increases in RANTES mRNA and protein expression were suppressed by the NF-kappaB inhibitors gliotoxin, isohelenin, and pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	152-156	nuclear factor kappa B subunit 1	Homo sapiens	75-84
11272138-6	2001	Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production.	pyrrolidine dithiocarbamic acid	87-114	interferon gamma	Rattus norvegicus	142-151
11272138-6	2001	Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production.	pyrrolidine dithiocarbamic acid	87-114	nitric oxide synthase 2	Rattus norvegicus	160-164
11272138-6	2001	Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production.	pyrrolidine dithiocarbamic acid	116-120	interferon gamma	Rattus norvegicus	142-151
11272138-6	2001	Inhibitors of NF-kappaB activation-the proteasome inhibitor MG-132 and the antioxidant pyrrolidine-dithiocarbamate (PDTC)-prevented poly IC + IFN-gamma-induced iNOS expression and nitric oxide production.	pyrrolidine dithiocarbamic acid	116-120	nitric oxide synthase 2	Rattus norvegicus	160-164
11360927-3	2001	Thus, we explored the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor-kappaB (NF-kappaB) in serum-exposed condition, on the activation of mitogen activated protein kinase (MAPK), especially, JNK/SAPK and p38 MAPK induction.	pyrrolidine dithiocarbamic acid	32-59	mitogen-activated protein kinase 9	Homo sapiens	248-252
11360927-3	2001	Thus, we explored the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor-kappaB (NF-kappaB) in serum-exposed condition, on the activation of mitogen activated protein kinase (MAPK), especially, JNK/SAPK and p38 MAPK induction.	pyrrolidine dithiocarbamic acid	61-65	mitogen-activated protein kinase 8	Homo sapiens	244-247
11360927-3	2001	Thus, we explored the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor-kappaB (NF-kappaB) in serum-exposed condition, on the activation of mitogen activated protein kinase (MAPK), especially, JNK/SAPK and p38 MAPK induction.	pyrrolidine dithiocarbamic acid	61-65	mitogen-activated protein kinase 9	Homo sapiens	248-252
11313966-4	2001	Pyrrolidine dithiocarbamate (PDTC), a presumed antioxidant, induced JNK activation on its own and enhanced JNK activation by H(2)O(2) in many cell types, including Jurkat, HEK293, and LNCaP and Tsu-Pr1 prostate cancer cells.	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 8	Homo sapiens	107-110
11181838-5	2001	We found that survival of these neurons in high potassium medium is blocked by three separate inhibitors of NF-kappaB activity: SN-50, N-tosyl-L-phenylalanine chloromethyl ketone and pyrrolidinedithiocarbamate, indicating that NF-kappaB is required for neuronal survival.	pyrrolidine dithiocarbamic acid	183-209	nuclear factor kappa B subunit 1	Homo sapiens	108-117
11313966-0	2001	Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	117-144	mitogen-activated protein kinase 8	Homo sapiens	23-46
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nitric oxide synthase 2	Homo sapiens	61-92
11313966-0	2001	Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	117-144	mitogen-activated protein kinase 8	Homo sapiens	48-51
11313966-0	2001	Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	117-144	mitogen-activated protein kinase 8	Homo sapiens	88-91
11313966-4	2001	Pyrrolidine dithiocarbamate (PDTC), a presumed antioxidant, induced JNK activation on its own and enhanced JNK activation by H(2)O(2) in many cell types, including Jurkat, HEK293, and LNCaP and Tsu-Pr1 prostate cancer cells.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 8	Homo sapiens	68-71
11313966-4	2001	Pyrrolidine dithiocarbamate (PDTC), a presumed antioxidant, induced JNK activation on its own and enhanced JNK activation by H(2)O(2) in many cell types, including Jurkat, HEK293, and LNCaP and Tsu-Pr1 prostate cancer cells.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 8	Homo sapiens	107-110
11313966-4	2001	Pyrrolidine dithiocarbamate (PDTC), a presumed antioxidant, induced JNK activation on its own and enhanced JNK activation by H(2)O(2) in many cell types, including Jurkat, HEK293, and LNCaP and Tsu-Pr1 prostate cancer cells.	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 8	Homo sapiens	68-71
11165942-3	2001	In addition, the stimulation of IL-6 release was also reduced by pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which has been reported to be a potent NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	65-92	interleukin 6	Homo sapiens	32-36
11165942-3	2001	In addition, the stimulation of IL-6 release was also reduced by pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which has been reported to be a potent NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	94-98	interleukin 6	Homo sapiens	32-36
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nitric oxide synthase 2	Homo sapiens	94-98
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nitric oxide synthase 2	Homo sapiens	178-182
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nuclear factor kappa B subunit 1	Homo sapiens	235-243
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nuclear factor kappa B subunit 1	Homo sapiens	350-358
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	286-313	nuclear factor kappa B subunit 1	Homo sapiens	350-358
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nitric oxide synthase 2	Homo sapiens	61-92
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nitric oxide synthase 2	Homo sapiens	94-98
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nitric oxide synthase 2	Homo sapiens	178-182
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nuclear factor kappa B subunit 1	Homo sapiens	235-243
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nuclear factor kappa B subunit 1	Homo sapiens	350-358
11340304-3	2001	After 3 h exposure to 400 microM nitrilotriacetate (NTA)-Fe, inducible nitric oxide synthase (iNOS) mRNA expression was significantly increased, with a corresponding increase in iNOS protein after 12 h. The nuclear binding activity of NFkappaB with 400 microM NTA-Fe was increased, and pyrrolidine dithiocarbamate (PDTC), an antioxidant inhibitor of NFkappaB, prevented both activation of NFkappaB and NO production in response to NTA-Fe.	pyrrolidine dithiocarbamic acid	315-319	nuclear factor kappa B subunit 1	Homo sapiens	350-358
11530235-6	2001	The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA.	pyrrolidine dithiocarbamic acid	22-49	interleukin 1 beta	Rattus norvegicus	60-77
11133225-8	2001	Pretreatment of HUVEC with pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC) completely prevented IL-4-induced VCAM-1 expression.	pyrrolidine dithiocarbamic acid	27-54	interleukin 4	Homo sapiens	109-113
11133225-8	2001	Pretreatment of HUVEC with pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC) completely prevented IL-4-induced VCAM-1 expression.	pyrrolidine dithiocarbamic acid	27-54	vascular cell adhesion molecule 1	Homo sapiens	122-128
11133225-8	2001	Pretreatment of HUVEC with pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC) completely prevented IL-4-induced VCAM-1 expression.	pyrrolidine dithiocarbamic acid	56-60	interleukin 4	Homo sapiens	109-113
11133225-8	2001	Pretreatment of HUVEC with pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC) completely prevented IL-4-induced VCAM-1 expression.	pyrrolidine dithiocarbamic acid	56-60	vascular cell adhesion molecule 1	Homo sapiens	122-128
11530235-7	2001	In contrast, pyrrolidine dithiocarbamate significantly inhibited COX-2 gene expression at the posttranscriptional level, since pyrrolidine dithiocarbamate did not affect interleukin 1beta-induced COX-2 mRNA transcripts but inhibited COX-2 protein expression and prostaglandin E(2) production.	pyrrolidine dithiocarbamic acid	13-40	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	65-70
11530235-10	2001	Furthermore, both pyrrolidine dithiocarbamate and rotenone also decreased interleukin 1beta-induced 8-isoprostaglandin F(2alpha) production.	pyrrolidine dithiocarbamic acid	18-45	interleukin 1 beta	Rattus norvegicus	74-91
11090967-0	2000	Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells.	pyrrolidine dithiocarbamic acid	46-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-98
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	78-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
11090967-4	2000	Treatment with a retinoid (9-cis-retinoic acid (9-cis-RA)) or an antioxidant (pyrrolidinedithiocarbamate (PDTC)) suppressed COX-2 expression and PGE(2) biosynthesis in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	106-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
10995749-4	2000	The transactivation of Smad7 by CD40 is NFkappaB-dependent in that pharmacological inhibitors of this pathway, N-tosyl-l-phenylalanine chloromethyl ketone and pyrrolidine dithiocarbamate, abrogate CD40-induced Smad7 expression.	pyrrolidine dithiocarbamic acid	159-186	SMAD family member 7	Mus musculus	23-28
12094615-7	2001	These effects were preventable by cotreatment with inhibitors of NF-kappa B activity, such as sodium salicylate, aspirin, or pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	125-152	nuclear factor kappa B subunit 1	Homo sapiens	65-75
11121439-5	2000	Pyrrolidine dithiocarbamate, a metal chelator and antioxidant, efficiently inhibited the FADD-induced reduction of DeltaPsim and necrotic cell death.	pyrrolidine dithiocarbamic acid	0-27	Fas associated via death domain	Homo sapiens	89-93
10995749-4	2000	The transactivation of Smad7 by CD40 is NFkappaB-dependent in that pharmacological inhibitors of this pathway, N-tosyl-l-phenylalanine chloromethyl ketone and pyrrolidine dithiocarbamate, abrogate CD40-induced Smad7 expression.	pyrrolidine dithiocarbamic acid	159-186	CD40 antigen	Mus musculus	32-36
11078703-7	2000	Pyrrolidine dithiocarbamate, an antioxidant molecule, and BXT-51072, a gluthation peroxidase mimic, both inhibited the shear-induced iNOS expression.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Homo sapiens	133-137
11024008-5	2000	Pretreatment with pertussis toxin or pyrrolidine dithiocarbamate inhibited complement-dependent IL-6 mRNA expression and IL-6 release, suggesting the involvement of Gi-proteins and nuclear factor-kB (NF-kB).	pyrrolidine dithiocarbamic acid	37-64	interleukin 6	Homo sapiens	96-100
11024008-5	2000	Pretreatment with pertussis toxin or pyrrolidine dithiocarbamate inhibited complement-dependent IL-6 mRNA expression and IL-6 release, suggesting the involvement of Gi-proteins and nuclear factor-kB (NF-kB).	pyrrolidine dithiocarbamic acid	37-64	interleukin 6	Homo sapiens	121-125
11108735-5	2000	The increase in ALBP/aP2 mRNA and protein in oxLDL-stimulated THP-1 macrophages is concentration and time dependent and is inhibited by treatment of the cells with an antioxidant inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate (PDTC), and with protein kinase C (PKC) inhibitors bisindolylmaleimide I and Ro-31-8220.	pyrrolidine dithiocarbamic acid	227-254	fatty acid binding protein 4	Homo sapiens	16-24
11108735-5	2000	The increase in ALBP/aP2 mRNA and protein in oxLDL-stimulated THP-1 macrophages is concentration and time dependent and is inhibited by treatment of the cells with an antioxidant inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate (PDTC), and with protein kinase C (PKC) inhibitors bisindolylmaleimide I and Ro-31-8220.	pyrrolidine dithiocarbamic acid	227-254	GLI family zinc finger 2	Homo sapiens	62-67
11108735-5	2000	The increase in ALBP/aP2 mRNA and protein in oxLDL-stimulated THP-1 macrophages is concentration and time dependent and is inhibited by treatment of the cells with an antioxidant inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate (PDTC), and with protein kinase C (PKC) inhibitors bisindolylmaleimide I and Ro-31-8220.	pyrrolidine dithiocarbamic acid	256-260	fatty acid binding protein 4	Homo sapiens	16-24
11108735-5	2000	The increase in ALBP/aP2 mRNA and protein in oxLDL-stimulated THP-1 macrophages is concentration and time dependent and is inhibited by treatment of the cells with an antioxidant inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate (PDTC), and with protein kinase C (PKC) inhibitors bisindolylmaleimide I and Ro-31-8220.	pyrrolidine dithiocarbamic acid	256-260	GLI family zinc finger 2	Homo sapiens	62-67
11093766-5	2000	The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA.	pyrrolidine dithiocarbamic acid	25-52	interferon gamma	Rattus norvegicus	122-138
11093766-5	2000	The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA.	pyrrolidine dithiocarbamic acid	25-52	nitric oxide synthase 2	Rattus norvegicus	236-240
11093766-5	2000	The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA.	pyrrolidine dithiocarbamic acid	25-52	solute carrier family 7 member 2	Rattus norvegicus	245-251
11093771-3	2000	Here we demonstrate that the potent inhibitor of nuclear factor kappaB activation, pyrrolidine dithiocarbamate (PDTC; 30-100 microM), induces de novo ET(B)-R expression in rat aortic and mesenteric cultured SMC.	pyrrolidine dithiocarbamic acid	83-110	endothelin receptor type B	Rattus norvegicus	150-157
11093771-3	2000	Here we demonstrate that the potent inhibitor of nuclear factor kappaB activation, pyrrolidine dithiocarbamate (PDTC; 30-100 microM), induces de novo ET(B)-R expression in rat aortic and mesenteric cultured SMC.	pyrrolidine dithiocarbamic acid	112-116	endothelin receptor type B	Rattus norvegicus	150-157
11192539-7	2000	In addition, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC) also effectively inhibited BLM-induced IL-8 production.	pyrrolidine dithiocarbamic acid	53-80	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11192539-7	2000	In addition, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC) also effectively inhibited BLM-induced IL-8 production.	pyrrolidine dithiocarbamic acid	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11097862-2	2000	Exposure of HepG2 cells to the GCS-inducing agent, Pyrrolidine dithiocarbamate (PDTC), results in ERK and p38 MAP kinase activation.	pyrrolidine dithiocarbamic acid	51-78	mitogen-activated protein kinase 14	Homo sapiens	106-109
11097862-2	2000	Exposure of HepG2 cells to the GCS-inducing agent, Pyrrolidine dithiocarbamate (PDTC), results in ERK and p38 MAP kinase activation.	pyrrolidine dithiocarbamic acid	80-84	mitogen-activated protein kinase 14	Homo sapiens	106-109
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	78-105	NFKB inhibitor alpha	Homo sapiens	150-165
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	78-105	nuclear factor kappa B subunit 1	Homo sapiens	267-277
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	78-105	NFKB inhibitor alpha	Homo sapiens	325-340
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	107-111	NFKB inhibitor alpha	Homo sapiens	150-165
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	107-111	nuclear factor kappa B subunit 1	Homo sapiens	267-277
11076697-7	2000	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.	pyrrolidine dithiocarbamic acid	107-111	NFKB inhibitor alpha	Homo sapiens	325-340
11068016-5	2000	Caspase-3 activation by TNF-alpha was significantly enhanced by pretreatment with both cycloheximide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	105-132	caspase 3	Homo sapiens	0-9
11068016-5	2000	Caspase-3 activation by TNF-alpha was significantly enhanced by pretreatment with both cycloheximide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	105-132	tumor necrosis factor	Homo sapiens	24-33
11068016-7	2000	Furthermore, TNF-alpha increased NF-kappaB DNA binding, which was abolished by pretreatment with pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	97-124	tumor necrosis factor	Homo sapiens	13-22
11053480-10	2000	Stimulation of TEC with CD40L results in activation of NF-kappaB and induction of cytokine production by IL-17 and CD40L is prevented by addition of the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	173-200	CD40 ligand	Homo sapiens	24-29
11053480-10	2000	Stimulation of TEC with CD40L results in activation of NF-kappaB and induction of cytokine production by IL-17 and CD40L is prevented by addition of the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	173-200	interleukin 17A	Homo sapiens	105-110
11053480-10	2000	Stimulation of TEC with CD40L results in activation of NF-kappaB and induction of cytokine production by IL-17 and CD40L is prevented by addition of the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	173-200	CD40 ligand	Homo sapiens	115-120
11046059-7	2000	Fibrin(ogen) stimulation of ICAM-1 could be suppressed by pyrrolidinedithiocarbamate, an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	58-84	intercellular adhesion molecule 1	Homo sapiens	28-34
11079460-8	2000	Additionally, the ethanol-mediated potentiation of TNF-alpha-inducible NFkappaB activation was abrogated by the known antioxidant pyrrolidinedithiocarbamate, suggesting an important mechanistic role for reactive oxygen species in this process.	pyrrolidine dithiocarbamic acid	130-156	tumor necrosis factor	Homo sapiens	51-60
11079460-8	2000	Additionally, the ethanol-mediated potentiation of TNF-alpha-inducible NFkappaB activation was abrogated by the known antioxidant pyrrolidinedithiocarbamate, suggesting an important mechanistic role for reactive oxygen species in this process.	pyrrolidine dithiocarbamic acid	130-156	nuclear factor kappa B subunit 1	Homo sapiens	71-79
11530235-6	2001	The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA.	pyrrolidine dithiocarbamic acid	22-49	nitric oxide synthase 2	Rattus norvegicus	86-91
11530235-6	2001	The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA.	pyrrolidine dithiocarbamic acid	22-49	nitric oxide synthase 2	Rattus norvegicus	261-266
11530235-6	2001	The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA.	pyrrolidine dithiocarbamic acid	22-49	nitric oxide synthase 2	Rattus norvegicus	261-266
10998154-6	2000	Furthermore, pyrrolidine dithiocarbamate inhibited the hapten-induced interleukin-1alpha production and NF-kappaB expression by Pam 212 cells.	pyrrolidine dithiocarbamic acid	13-40	interleukin 1 alpha	Mus musculus	70-88
11074303-7	2000	A variety of antioxidants, such as catalase, superoxide dismutase, N-acetyl cysteine (NAC), and pyrrolidine dithiocarbamate, inhibited NF-kappaB activation induced by pervanadate in the presence of silica.	pyrrolidine dithiocarbamic acid	96-123	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
10998350-0	2000	p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes.	pyrrolidine dithiocarbamic acid	55-82	tumor protein p53	Homo sapiens	0-3
10998350-0	2000	p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes.	pyrrolidine dithiocarbamic acid	55-82	tumor protein p53	Homo sapiens	126-129
10998350-0	2000	p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes.	pyrrolidine dithiocarbamic acid	55-82	tumor protein p53	Homo sapiens	126-129
10998350-3	2000	Treatment of MCF7 breast cancer cells with pyrrolidine dithiocarbamate (PDTC), a metal chelator, resulted in a minimum of 25% oxidation of p53.	pyrrolidine dithiocarbamic acid	43-70	tumor protein p53	Homo sapiens	139-142
10998350-3	2000	Treatment of MCF7 breast cancer cells with pyrrolidine dithiocarbamate (PDTC), a metal chelator, resulted in a minimum of 25% oxidation of p53.	pyrrolidine dithiocarbamic acid	72-76	tumor protein p53	Homo sapiens	139-142
10998350-8	2000	However, when cells were simultaneously treated with PDTC and actinomycin D, p53 accumulated in both the nucleus and the cytoplasm.	pyrrolidine dithiocarbamic acid	53-57	tumor protein p53	Homo sapiens	77-80
10956637-6	2000	Gel shift and Western blot analyses confirmed that TNF-alpha activated NF-kappaB and depleted IkappaB in this system and that these effects were prevented by MG-132 and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	169-196	tumor necrosis factor	Rattus norvegicus	51-60
10801793-6	2000	Pyrrolidine dithiocarbamate (PDTC), which exerts both antioxidant and pro-oxidant effects, provoked a substantial increase in HIF-1alpha nuclear abundance, with no apparent effect on its activation.	pyrrolidine dithiocarbamic acid	0-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
10878378-7	2000	The antioxidants N-acetylcysteine and pyrrolidinedithiocarbamic acid abolished the hypoxic activation of NF-kappa B, TNF-alpha gene transcription, and increases in ROS levels.	pyrrolidine dithiocarbamic acid	38-68	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-115
10878378-7	2000	The antioxidants N-acetylcysteine and pyrrolidinedithiocarbamic acid abolished the hypoxic activation of NF-kappa B, TNF-alpha gene transcription, and increases in ROS levels.	pyrrolidine dithiocarbamic acid	38-68	tumor necrosis factor	Mus musculus	117-126
11006087-0	2000	Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Homo sapiens	37-46
10976995-7	2000	Protein tyrosine kinase (PTK) inhibitors such as genistein and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the suppressive effect of titanium on collagen gene expression suggesting particles suppress collagen gene expression through the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	87-114	nuclear factor kappa B subunit 1	Homo sapiens	67-76
10976995-7	2000	Protein tyrosine kinase (PTK) inhibitors such as genistein and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the suppressive effect of titanium on collagen gene expression suggesting particles suppress collagen gene expression through the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	87-114	nuclear factor kappa B subunit 1	Homo sapiens	274-283
10976995-7	2000	Protein tyrosine kinase (PTK) inhibitors such as genistein and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the suppressive effect of titanium on collagen gene expression suggesting particles suppress collagen gene expression through the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	116-120	nuclear factor kappa B subunit 1	Homo sapiens	67-76
10976995-7	2000	Protein tyrosine kinase (PTK) inhibitors such as genistein and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the suppressive effect of titanium on collagen gene expression suggesting particles suppress collagen gene expression through the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	116-120	nuclear factor kappa B subunit 1	Homo sapiens	274-283
10833515-8	2000	Treatment of the BCR/ABL-expressing cell line MO7/p210 with the reducing agents pyrrolidine dithiocarbamate or N-acetylcysteine reduced the accumulation of ROS and also decreased tyrosine phosphorylation of cellular proteins.	pyrrolidine dithiocarbamic acid	80-107	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	17-24
10801793-6	2000	Pyrrolidine dithiocarbamate (PDTC), which exerts both antioxidant and pro-oxidant effects, provoked a substantial increase in HIF-1alpha nuclear abundance, with no apparent effect on its activation.	pyrrolidine dithiocarbamic acid	29-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
10886052-7	2000	Nuclear factor-kappa B (NF-kappa B) inhibitor pyrrolidinedithiocarbamate abolished iNOS and nitric oxide production.	pyrrolidine dithiocarbamic acid	46-72	nuclear factor kappa B subunit 1	Homo sapiens	0-22
10886052-7	2000	Nuclear factor-kappa B (NF-kappa B) inhibitor pyrrolidinedithiocarbamate abolished iNOS and nitric oxide production.	pyrrolidine dithiocarbamic acid	46-72	nuclear factor kappa B subunit 1	Homo sapiens	24-34
10886052-7	2000	Nuclear factor-kappa B (NF-kappa B) inhibitor pyrrolidinedithiocarbamate abolished iNOS and nitric oxide production.	pyrrolidine dithiocarbamic acid	46-72	nitric oxide synthase 2	Homo sapiens	83-87
10843690-10	2000	We found that the NF-kappa B inhibitor pyrrolidinedithiocarbamate prevented nitrite production, iNOS induction, and mRNA accumulation by sPLA2 plus LPS in Raw264.7 cells.	pyrrolidine dithiocarbamic acid	39-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-28
11058855-6	2000	Elastase, carboxypeptidase A, and lipase induced degradation of I kappa B-beta (but not I kappa B-alpha), activation of NF-kappa B, and production of TNF-alpha protein, whereas inhibition of I kappa B with pyrrolidine dithiocarbamate attenuated this response.	pyrrolidine dithiocarbamic acid	206-233	lipase G, endothelial type	Rattus norvegicus	34-40
10880263-6	2000	Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM.	pyrrolidine dithiocarbamic acid	116-142	nuclear factor kappa B subunit 1	Homo sapiens	92-101
10880263-6	2000	Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha, IL-1beta and OSM.	pyrrolidine dithiocarbamic acid	116-142	interleukin 6	Homo sapiens	156-160
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	0-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-57
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	0-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-57
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
10843690-10	2000	We found that the NF-kappa B inhibitor pyrrolidinedithiocarbamate prevented nitrite production, iNOS induction, and mRNA accumulation by sPLA2 plus LPS in Raw264.7 cells.	pyrrolidine dithiocarbamic acid	39-65	nitric oxide synthase 2, inducible	Mus musculus	96-100
10843690-10	2000	We found that the NF-kappa B inhibitor pyrrolidinedithiocarbamate prevented nitrite production, iNOS induction, and mRNA accumulation by sPLA2 plus LPS in Raw264.7 cells.	pyrrolidine dithiocarbamic acid	39-65	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	137-142
10843690-11	2000	Furthermore, EMSA analysis of the activation of the NF-kappa B involved in iNOS induction demonstrated that pyrrolidinedithiocarbamate prevented the NF-kappa B binding by sPLA2 plus LPS.	pyrrolidine dithiocarbamic acid	108-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-62
10843690-11	2000	Furthermore, EMSA analysis of the activation of the NF-kappa B involved in iNOS induction demonstrated that pyrrolidinedithiocarbamate prevented the NF-kappa B binding by sPLA2 plus LPS.	pyrrolidine dithiocarbamic acid	108-134	nitric oxide synthase 2, inducible	Mus musculus	75-79
10843690-11	2000	Furthermore, EMSA analysis of the activation of the NF-kappa B involved in iNOS induction demonstrated that pyrrolidinedithiocarbamate prevented the NF-kappa B binding by sPLA2 plus LPS.	pyrrolidine dithiocarbamic acid	108-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-159
10843690-11	2000	Furthermore, EMSA analysis of the activation of the NF-kappa B involved in iNOS induction demonstrated that pyrrolidinedithiocarbamate prevented the NF-kappa B binding by sPLA2 plus LPS.	pyrrolidine dithiocarbamic acid	108-134	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	171-176
10788433-10	2000	Treatment with the antioxidant pyrrolidine dithiocarbamate, which is known to inhibit NF-kappaB and sphingomyelinase in C6 cells, or with the peptide SN-50, which blocks translocation of NF-kappaB to the nucleus, inhibited TNF-alpha-dependent iNOS mRNA expression without affecting GTPCH mRNA levels.	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	86-95
10894110-10	2000	Both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	pyrrolidine dithiocarbamic acid	26-53	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10799861-10	2000	In addition, pyrrolidine dithiocarbamate partially down-regulated CD40L-induced VEGF production, showing that the NF-kappaB pathway was partly involved in the signaling of CD40L leading to VEGF production.	pyrrolidine dithiocarbamic acid	13-40	CD40 ligand	Homo sapiens	66-71
10799861-10	2000	In addition, pyrrolidine dithiocarbamate partially down-regulated CD40L-induced VEGF production, showing that the NF-kappaB pathway was partly involved in the signaling of CD40L leading to VEGF production.	pyrrolidine dithiocarbamic acid	13-40	vascular endothelial growth factor A	Homo sapiens	80-84
10799861-10	2000	In addition, pyrrolidine dithiocarbamate partially down-regulated CD40L-induced VEGF production, showing that the NF-kappaB pathway was partly involved in the signaling of CD40L leading to VEGF production.	pyrrolidine dithiocarbamic acid	13-40	CD40 ligand	Homo sapiens	172-177
10799861-10	2000	In addition, pyrrolidine dithiocarbamate partially down-regulated CD40L-induced VEGF production, showing that the NF-kappaB pathway was partly involved in the signaling of CD40L leading to VEGF production.	pyrrolidine dithiocarbamic acid	13-40	vascular endothelial growth factor A	Homo sapiens	189-193
10927178-5	2000	Pyrrolidine dithiocarbamate (PDTC) markedly represses cytokine-induced VCAM-1 gene expression in cultured human endothelial cells; however, its effects on the oxidative second messenger pathway are unknown.	pyrrolidine dithiocarbamic acid	0-27	vascular cell adhesion molecule 1	Homo sapiens	71-77
10927178-5	2000	Pyrrolidine dithiocarbamate (PDTC) markedly represses cytokine-induced VCAM-1 gene expression in cultured human endothelial cells; however, its effects on the oxidative second messenger pathway are unknown.	pyrrolidine dithiocarbamic acid	29-33	vascular cell adhesion molecule 1	Homo sapiens	71-77
10807870-11	2000	The importance of NF-kappaB in endothelial apoptosis was confirmed by the observation that pyrrolidine dithiocarbamate, a potent NF-kappaB inhibitor, prevented endothelial apoptosis, caspase 3-like activity, and bcl-2 downregulation induced by hypoxia.	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	18-27
10807870-11	2000	The importance of NF-kappaB in endothelial apoptosis was confirmed by the observation that pyrrolidine dithiocarbamate, a potent NF-kappaB inhibitor, prevented endothelial apoptosis, caspase 3-like activity, and bcl-2 downregulation induced by hypoxia.	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	129-138
10807870-11	2000	The importance of NF-kappaB in endothelial apoptosis was confirmed by the observation that pyrrolidine dithiocarbamate, a potent NF-kappaB inhibitor, prevented endothelial apoptosis, caspase 3-like activity, and bcl-2 downregulation induced by hypoxia.	pyrrolidine dithiocarbamic acid	91-118	BCL2 apoptosis regulator	Homo sapiens	212-217
10788433-10	2000	Treatment with the antioxidant pyrrolidine dithiocarbamate, which is known to inhibit NF-kappaB and sphingomyelinase in C6 cells, or with the peptide SN-50, which blocks translocation of NF-kappaB to the nucleus, inhibited TNF-alpha-dependent iNOS mRNA expression without affecting GTPCH mRNA levels.	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	187-196
10826501-8	2000	Moreover, the antioxidant pyrrolidine dithiocarbamate (10 microM) inhibited ET-1-induced IL-6 release indicating involvement of reactive oxygen species in ET-1 signaling.	pyrrolidine dithiocarbamic acid	26-53	endothelin 1	Homo sapiens	76-80
10794675-5	2000	Inhibiting NF-kappaB activation with pyrrolidine dithiocarbamate (PD) blocks the normalization of SMIT mRNA levels and myo-inositol accumulation on removal of the cells from hyperosmotic medium.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	11-20
10794675-5	2000	Inhibiting NF-kappaB activation with pyrrolidine dithiocarbamate (PD) blocks the normalization of SMIT mRNA levels and myo-inositol accumulation on removal of the cells from hyperosmotic medium.	pyrrolidine dithiocarbamic acid	37-64	solute carrier family 5 member 3	Homo sapiens	98-102
10800947-8	2000	Glutamate-dependent iNOS expression was concentration-dependent and was blocked by EGTA and by the inhibitors of nuclear factor kappaB (NF-kappaB) activation pyrrolidine dithiocarbamate and MG132.	pyrrolidine dithiocarbamic acid	158-185	nitric oxide synthase 2	Rattus norvegicus	20-24
10777712-7	2000	The antioxidant and GSH precursor N-acetyl-l-cysteine favored Bcl-2 at the expense of Bax/p53, whereas pyrrolidine dithiocarbamate induced Bax against Bcl-2, with mild effect on p53.	pyrrolidine dithiocarbamic acid	103-130	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142
10777712-7	2000	The antioxidant and GSH precursor N-acetyl-l-cysteine favored Bcl-2 at the expense of Bax/p53, whereas pyrrolidine dithiocarbamate induced Bax against Bcl-2, with mild effect on p53.	pyrrolidine dithiocarbamic acid	103-130	BCL2 apoptosis regulator	Homo sapiens	151-156
10826501-8	2000	Moreover, the antioxidant pyrrolidine dithiocarbamate (10 microM) inhibited ET-1-induced IL-6 release indicating involvement of reactive oxygen species in ET-1 signaling.	pyrrolidine dithiocarbamic acid	26-53	interleukin 6	Homo sapiens	89-93
10826501-8	2000	Moreover, the antioxidant pyrrolidine dithiocarbamate (10 microM) inhibited ET-1-induced IL-6 release indicating involvement of reactive oxygen species in ET-1 signaling.	pyrrolidine dithiocarbamic acid	26-53	endothelin 1	Homo sapiens	155-159
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	pyrrolidine dithiocarbamic acid	35-62	caspase 3	Homo sapiens	167-176
10759767-5	2000	We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury.	pyrrolidine dithiocarbamic acid	52-79	tumor necrosis factor	Homo sapiens	123-132
10759767-5	2000	We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury.	pyrrolidine dithiocarbamic acid	81-85	tumor necrosis factor	Homo sapiens	123-132
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	pyrrolidine dithiocarbamic acid	35-62	caspase 8	Homo sapiens	199-208
10803841-4	2000	Furthermore, the stimulation of pIgR mRNA by TNF-alpha was decreased by pyrrolidinedithiocarbamate and L-1-4"-tosylamino-phenylethyl-chloromethyl ketone, which are known nuclear factor (NF)-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	72-98	polymeric immunoglobulin receptor	Homo sapiens	32-36
10803841-4	2000	Furthermore, the stimulation of pIgR mRNA by TNF-alpha was decreased by pyrrolidinedithiocarbamate and L-1-4"-tosylamino-phenylethyl-chloromethyl ketone, which are known nuclear factor (NF)-kappaB inhibitors.	pyrrolidine dithiocarbamic acid	72-98	tumor necrosis factor	Homo sapiens	45-54
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	pyrrolidine dithiocarbamic acid	64-68	caspase 3	Homo sapiens	167-176
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	pyrrolidine dithiocarbamic acid	64-68	caspase 8	Homo sapiens	199-208
10725743-6	2000	This potentiating effect was mediated by reactive oxygen species (ROS) released by PMN during the coculture; it did not require direct cell contact between PMN and PBMC, it was enhanced when PMN were stimulated by fMLP (a chemotactic peptide), and it was inhibited by two antioxidants, N-acetyl cysteine and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	308-335	formyl peptide receptor 1	Homo sapiens	214-218
10716998-5	2000	In human monocytes, the antioxidant pyrrolidine dithiocarbamate (PDTC) rapidly inhibited CCR2 (95-100% of inhibition) and CCR5 (77-100% of inhibition) mRNA expression by strongly decreasing transcript stability.	pyrrolidine dithiocarbamic acid	36-63	C-C motif chemokine receptor 2	Homo sapiens	89-93
10762665-5	2000	Two dithiocarbamates, pyrrolidine dithiocarbamate and diethyldithiocarbamate, showed concentration-dependent biphasic effects in inhibiting NF-kappaB activation in cerebral endothelial cells.	pyrrolidine dithiocarbamic acid	22-49	nuclear factor kappa B subunit 1	Homo sapiens	140-149
10706725-3	2000	Following stimulation with TNF-alpha, pyrrolidine dithiocarbamate (PDTC), N-acetylcysteine, and dexamethasone prevented I kappa B kinase-induced I kappa B-alpha, but not I kappa B-beta or I kappa B-epsilon phosphorylation and degradation.	pyrrolidine dithiocarbamic acid	38-65	NFKB inhibitor alpha	Homo sapiens	145-160
10706725-3	2000	Following stimulation with TNF-alpha, pyrrolidine dithiocarbamate (PDTC), N-acetylcysteine, and dexamethasone prevented I kappa B kinase-induced I kappa B-alpha, but not I kappa B-beta or I kappa B-epsilon phosphorylation and degradation.	pyrrolidine dithiocarbamic acid	38-65	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	188-205
10706725-3	2000	Following stimulation with TNF-alpha, pyrrolidine dithiocarbamate (PDTC), N-acetylcysteine, and dexamethasone prevented I kappa B kinase-induced I kappa B-alpha, but not I kappa B-beta or I kappa B-epsilon phosphorylation and degradation.	pyrrolidine dithiocarbamic acid	67-71	NFKB inhibitor alpha	Homo sapiens	145-160
10706725-3	2000	Following stimulation with TNF-alpha, pyrrolidine dithiocarbamate (PDTC), N-acetylcysteine, and dexamethasone prevented I kappa B kinase-induced I kappa B-alpha, but not I kappa B-beta or I kappa B-epsilon phosphorylation and degradation.	pyrrolidine dithiocarbamic acid	67-71	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	188-205
10716998-5	2000	In human monocytes, the antioxidant pyrrolidine dithiocarbamate (PDTC) rapidly inhibited CCR2 (95-100% of inhibition) and CCR5 (77-100% of inhibition) mRNA expression by strongly decreasing transcript stability.	pyrrolidine dithiocarbamic acid	36-63	C-C motif chemokine receptor 5	Homo sapiens	122-126
10716998-5	2000	In human monocytes, the antioxidant pyrrolidine dithiocarbamate (PDTC) rapidly inhibited CCR2 (95-100% of inhibition) and CCR5 (77-100% of inhibition) mRNA expression by strongly decreasing transcript stability.	pyrrolidine dithiocarbamic acid	65-69	C-C motif chemokine receptor 2	Homo sapiens	89-93
10716998-5	2000	In human monocytes, the antioxidant pyrrolidine dithiocarbamate (PDTC) rapidly inhibited CCR2 (95-100% of inhibition) and CCR5 (77-100% of inhibition) mRNA expression by strongly decreasing transcript stability.	pyrrolidine dithiocarbamic acid	65-69	C-C motif chemokine receptor 5	Homo sapiens	122-126
10733100-8	2000	The antioxidant pyrrolidine dithiocarbamate inhibited LPS-induced nuclear factor-kappaB (NF-kappaB) activation and TSG-14 expression in macrophages.	pyrrolidine dithiocarbamic acid	16-43	pentraxin related gene	Mus musculus	115-121
10696066-7	2000	Antioxidants, pyrrolidine dithiocarbamate, and N-acetyl-L-cysteine significantly inhibited IL-8 mRNA and protein levels by BET-1A cells.	pyrrolidine dithiocarbamic acid	14-41	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
10706556-9	2000	Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate sensitized them to TNF-alpha-induced apoptosis.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	14-23
10706556-9	2000	Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate sensitized them to TNF-alpha-induced apoptosis.	pyrrolidine dithiocarbamic acid	38-65	tumor necrosis factor	Homo sapiens	85-94
10728389-9	2000	CONCLUSIONS: Long-term treatment with the antioxidants probucol and pyrrolidine dithiocarbamate attenuates oxidative stress, myocyte apoptosis, caspase-3 like activity and the expression of p53, bax and caspase-3 within RM in rats after a large myocardial infarction.	pyrrolidine dithiocarbamic acid	68-95	caspase 3	Rattus norvegicus	144-153
10679310-0	2000	Pyrrolidine dithiocarbamate induces apoptosis by a cytochrome c-dependent mechanism.	pyrrolidine dithiocarbamic acid	0-27	cytochrome c, somatic	Homo sapiens	51-63
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	nuclear factor kappa B subunit 1	Homo sapiens	36-44
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	SRY-box transcription factor 9	Homo sapiens	48-52
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	nuclear factor kappa B subunit 1	Homo sapiens	150-158
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	interleukin 1 alpha	Homo sapiens	192-196
10652367-4	2000	A role for the transcription factor NFkappaB in Sox9 down-regulation was suggested by the ability of pyrrolidine dithiocarbamate, an inhibitor of the NFkappaB pathway, to block the effects of IL-1 and TNF-alpha.	pyrrolidine dithiocarbamic acid	101-128	tumor necrosis factor	Homo sapiens	201-210
10728389-9	2000	CONCLUSIONS: Long-term treatment with the antioxidants probucol and pyrrolidine dithiocarbamate attenuates oxidative stress, myocyte apoptosis, caspase-3 like activity and the expression of p53, bax and caspase-3 within RM in rats after a large myocardial infarction.	pyrrolidine dithiocarbamic acid	68-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	190-193
10728389-9	2000	CONCLUSIONS: Long-term treatment with the antioxidants probucol and pyrrolidine dithiocarbamate attenuates oxidative stress, myocyte apoptosis, caspase-3 like activity and the expression of p53, bax and caspase-3 within RM in rats after a large myocardial infarction.	pyrrolidine dithiocarbamic acid	68-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
10728389-9	2000	CONCLUSIONS: Long-term treatment with the antioxidants probucol and pyrrolidine dithiocarbamate attenuates oxidative stress, myocyte apoptosis, caspase-3 like activity and the expression of p53, bax and caspase-3 within RM in rats after a large myocardial infarction.	pyrrolidine dithiocarbamic acid	68-95	caspase 3	Rattus norvegicus	203-212
10636889-5	2000	Cadmium-induced apoptosis and mdr1 up-regulation depended on ROS, since co-incubation with the ROS scavengers N-acetylcysteine (15 mM) or pyrrolidine dithiocarbamate (0.1 mM) abolished both responses.	pyrrolidine dithiocarbamic acid	138-165	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
10619820-10	2000	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	14-23
10619820-10	2000	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	27-54	interleukin 1 beta	Homo sapiens	66-74
10619820-10	2000	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis.	pyrrolidine dithiocarbamic acid	27-54	tumor necrosis factor	Homo sapiens	79-88
10653978-6	2000	By exploiting the same transfection assay, we demonstrated that the up-regulation of the grp78 promoter by the protein phosphatase inhibitors is suppressed in the presence of the cytoplasmic calcium chelator bis(aminophenoxy)ethane N,N"-tetraacetic acid, the mitochondria calcium uniporter inhibitor ruthenium red as well as the antioxidants N-acetyl cysteine and pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	364-390	heat shock protein family A (Hsp70) member 5	Homo sapiens	89-94
10954053-5	2000	When the effect of the nuclear factor-KB inhibitor pyrrolidine dithiocarbamate (PDTC) and activating protein-1 inhibitor curcumin were examined, a dose-dependent inhibition of cytokine-activated NGF expression occurred in the presence of PDTC or curcumin.	pyrrolidine dithiocarbamic acid	51-78	nerve growth factor	Mus musculus	195-198
10954053-5	2000	When the effect of the nuclear factor-KB inhibitor pyrrolidine dithiocarbamate (PDTC) and activating protein-1 inhibitor curcumin were examined, a dose-dependent inhibition of cytokine-activated NGF expression occurred in the presence of PDTC or curcumin.	pyrrolidine dithiocarbamic acid	80-84	nerve growth factor	Mus musculus	195-198
10954053-5	2000	When the effect of the nuclear factor-KB inhibitor pyrrolidine dithiocarbamate (PDTC) and activating protein-1 inhibitor curcumin were examined, a dose-dependent inhibition of cytokine-activated NGF expression occurred in the presence of PDTC or curcumin.	pyrrolidine dithiocarbamic acid	238-242	nerve growth factor	Mus musculus	195-198
10617676-4	2000	The PKC inhibitors (Go 6976 and Ro 31-8220) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate, also attenuated IL-1beta-induced PGE(2) release and COX-2 expression.	pyrrolidine dithiocarbamic acid	69-96	interleukin 1 beta	Homo sapiens	114-122
10617676-4	2000	The PKC inhibitors (Go 6976 and Ro 31-8220) and NF-kappaB inhibitor, pyrrolidine dithiocarbamate, also attenuated IL-1beta-induced PGE(2) release and COX-2 expression.	pyrrolidine dithiocarbamic acid	69-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-155
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	42-68	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-144
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	42-68	heat shock protein family A (Hsp70) member 4	Homo sapiens	146-151
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	42-68	heme oxygenase 1	Homo sapiens	164-169
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	70-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-144
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	70-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	146-151
10672026-3	2000	We report here that the known antioxidant pyrrolidinedithiocarbamate (PDTC) leads to time and dose dependent activation of heat-shock protein 70 (Hsp70) as well as Hsp32 in EC.	pyrrolidine dithiocarbamic acid	70-74	heme oxygenase 1	Homo sapiens	164-169
10640752-4	2000	We found that surface expression and promoter activity of PECAM-1 in myeloid cells are regulated by modulators of NF-kappa B, including TNF-alpha, PMA, and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	156-183	platelet and endothelial cell adhesion molecule 1	Homo sapiens	58-65
10636889-6	2000	Moreover, cadmium- and ROS-associated mdr1 up-regulation was linked to activation of the transcription factor NF-kappaB; N-acetylcysteine, pyrrolidine dithiocarbamate, and the IkappaB-alpha kinase inhibitor Bay 11-7082 (20 microM) prevented both, mdr1 overexpression and degradation of the inhibitory NF-kappaB subunit, IkappaB-alpha, induced by cadmium.	pyrrolidine dithiocarbamic acid	139-166	ATP binding cassette subfamily B member 1	Homo sapiens	38-42
10594564-7	1999	In a second set of experiments we were able to show that coincubation of L2 cells with pyrrolidine dithiocarbamate (PDTC) significantly suppressed neopterin-induced ICAM-1 synthesis.	pyrrolidine dithiocarbamic acid	87-114	intercellular adhesion molecule 1	Homo sapiens	165-171
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	24-52	NFKB inhibitor alpha	Bos taurus	81-94
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	24-52	tumor necrosis factor	Bos taurus	157-166
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	24-52	tumor necrosis factor	Bos taurus	231-240
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	54-58	NFKB inhibitor alpha	Bos taurus	81-94
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	54-58	tumor necrosis factor	Bos taurus	157-166
12075419-5	2000	Our results showed that pyrrolidine dithio-carbamate (PDTC) completely inhibited IKappaB-alpha degradation and nuclear translocation of NF-KappaB induced by TNF-alpha, and other antioxidants also exhibited inhibitory activities on TNF-alpha-induced I B-alpha degradation.	pyrrolidine dithiocarbamic acid	54-58	tumor necrosis factor	Bos taurus	231-240
10594564-7	1999	In a second set of experiments we were able to show that coincubation of L2 cells with pyrrolidine dithiocarbamate (PDTC) significantly suppressed neopterin-induced ICAM-1 synthesis.	pyrrolidine dithiocarbamic acid	116-120	intercellular adhesion molecule 1	Homo sapiens	165-171
10564154-8	1999	In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content.	pyrrolidine dithiocarbamic acid	40-67	interleukin 1 beta	Homo sapiens	106-114
10594646-7	1999	Ca2 + reperfusion injury induced by Ca2 + depletion or H2O2 exposure was blocked by the iron chelator 1, 10-phenanthroline, the NF-kappaB inhibitor pyrrolidinedithiocarbamate and the calcineurin inhibitor FK506.	pyrrolidine dithiocarbamic acid	148-174	carbonic anhydrase 2	Homo sapiens	0-3
10594646-7	1999	Ca2 + reperfusion injury induced by Ca2 + depletion or H2O2 exposure was blocked by the iron chelator 1, 10-phenanthroline, the NF-kappaB inhibitor pyrrolidinedithiocarbamate and the calcineurin inhibitor FK506.	pyrrolidine dithiocarbamic acid	148-174	carbonic anhydrase 2	Homo sapiens	36-39
10567525-4	1999	Pyrrolidine dithiocarbamate (PDTC) blocked activation of NF-kappaB and led to prominent cell death.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
10567525-4	1999	Pyrrolidine dithiocarbamate (PDTC) blocked activation of NF-kappaB and led to prominent cell death.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
10630576-4	1999	We have now tested the protective effects of antioxidants vitamin E (alpha-tocopherol) and pyrrolidine dithiocarbamate (PDTC) on endothelial cell activation induced by PCB 77.	pyrrolidine dithiocarbamic acid	91-118	pyruvate carboxylase	Homo sapiens	168-171
10630576-4	1999	We have now tested the protective effects of antioxidants vitamin E (alpha-tocopherol) and pyrrolidine dithiocarbamate (PDTC) on endothelial cell activation induced by PCB 77.	pyrrolidine dithiocarbamic acid	120-124	pyruvate carboxylase	Homo sapiens	168-171
10559251-1	1999	Exposure of HepG2 cells to beta-naphthoflavone (beta-NF) or pyrrolidine dithiocarbamate (PDTC) resulted in the up-regulation of the gamma-glutamylcysteine synthetase catalytic (GCS(h)) and regulatory (GCS(l)) subunit genes.	pyrrolidine dithiocarbamic acid	60-87	glycine cleavage system protein H	Homo sapiens	132-183
10559251-1	1999	Exposure of HepG2 cells to beta-naphthoflavone (beta-NF) or pyrrolidine dithiocarbamate (PDTC) resulted in the up-regulation of the gamma-glutamylcysteine synthetase catalytic (GCS(h)) and regulatory (GCS(l)) subunit genes.	pyrrolidine dithiocarbamic acid	89-93	glycine cleavage system protein H	Homo sapiens	132-183
10564154-8	1999	In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta-induced NF-kappaB activation but had no effect on intracellular sulfhydryl content.	pyrrolidine dithiocarbamic acid	40-67	nuclear factor kappa B subunit 1	Homo sapiens	123-132
10555036-11	1999	Specific protein kinase inhibitors for MEK-1/2 (PD98059), p38 (SB202190), and nuclear factor kappaB (NF-kappaB) (pyrrolidine dithiocarbamate) each markedly decreased the IL-17-increased iNOS level and NO production.	pyrrolidine dithiocarbamic acid	113-140	interleukin 17A	Homo sapiens	170-175
10555036-11	1999	Specific protein kinase inhibitors for MEK-1/2 (PD98059), p38 (SB202190), and nuclear factor kappaB (NF-kappaB) (pyrrolidine dithiocarbamate) each markedly decreased the IL-17-increased iNOS level and NO production.	pyrrolidine dithiocarbamic acid	113-140	nitric oxide synthase 2	Homo sapiens	186-190
10560834-11	1999	Further experiments demonstrated that pyrrolidine dithiocarbamate (PDTC), which is from a family of molecules that induce TD, inhibited both nitric oxide production and proteoglycan degradation.	pyrrolidine dithiocarbamic acid	38-65	versican	Gallus gallus	169-181
10531399-7	1999	Down-regulation of the A(2A)AR at 1 day was mimicked by activators of NFkappaB, such as H(2)O(2), and ceramide, and was attenuated by the inhibitor pyrrolidine dithiocarbamate or following transient transfection of PC12 cells with a dominant negative IkappaBalpha mutant.	pyrrolidine dithiocarbamic acid	148-175	NFKB inhibitor alpha	Rattus norvegicus	251-263
10630630-13	1999	The enhancement of the activity of transfected chimeric CAT constructs by TPA was abrogated by calphostin C and by pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB and AP-1 transactivation).	pyrrolidine dithiocarbamic acid	115-142	catalase	Homo sapiens	56-59
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	14-41	reticuloendotheliosis oncogene	Mus musculus	62-67
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	14-41	reticuloendotheliosis oncogene	Mus musculus	109-114
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	43-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
10497315-10	1999	Inhibition by pyrrolidine dithiocarbamate (PDTC), a NF-kappaB/c-rel inhibitor, and EMSA imply that NF-kappaB/c-rel is important in their expressions.	pyrrolidine dithiocarbamic acid	43-47	reticuloendotheliosis oncogene	Mus musculus	109-114
10560834-11	1999	Further experiments demonstrated that pyrrolidine dithiocarbamate (PDTC), which is from a family of molecules that induce TD, inhibited both nitric oxide production and proteoglycan degradation.	pyrrolidine dithiocarbamic acid	67-71	versican	Gallus gallus	169-181
10516652-12	1999	Pyrrolidine dithiocarbamate (PDTC: 10 - 200 microM) and 3,4 dichloroisocoumarin (0.1 - 100 microM) reduced cytokine-induced iNOS activity and protein expression at both day 10 and 15 after confluence.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Homo sapiens	124-128
10382751-0	1999	Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	toll-like receptor 4	Mus musculus	71-74
10505697-13	1999	Electrophoretic mobility shift assay of nuclear extracts from PAEC exposed to human serum revealed an intense NF-kappaB activation that was inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	177-203	nuclear factor kappa B subunit 1	Homo sapiens	110-119
10505697-13	1999	Electrophoretic mobility shift assay of nuclear extracts from PAEC exposed to human serum revealed an intense NF-kappaB activation that was inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	177-203	nuclear factor kappa B subunit 1	Homo sapiens	157-166
10479653-2	1999	In rat aortic smooth muscle cells, the antioxidants N-acetyl-L-cysteine (5 mmol/L) and pyrrolidine dithiocarbamate (100 micromol/L) completely inhibited angiotensin II-stimulated increases in IGF-1R mRNA and protein levels, suggesting the involvement of reactive oxygen species.	pyrrolidine dithiocarbamic acid	87-114	angiotensinogen	Rattus norvegicus	153-167
10479653-2	1999	In rat aortic smooth muscle cells, the antioxidants N-acetyl-L-cysteine (5 mmol/L) and pyrrolidine dithiocarbamate (100 micromol/L) completely inhibited angiotensin II-stimulated increases in IGF-1R mRNA and protein levels, suggesting the involvement of reactive oxygen species.	pyrrolidine dithiocarbamic acid	87-114	insulin-like growth factor 1 receptor	Rattus norvegicus	192-198
10533675-0	1999	Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs.	pyrrolidine dithiocarbamic acid	24-51	surfactant protein A1	Homo sapiens	79-105
10533675-3	1999	In the current work, increased levels of oxidized glutathione (GSSG) are demonstrated at doses of pyrrolidine dithiocarbamate (PDTC) which decrease SP-A and SP-B mRNAs, suggesting that cellular oxidation reduces surfactant protein expression.	pyrrolidine dithiocarbamic acid	98-125	surfactant protein A1	Homo sapiens	148-152
10533675-3	1999	In the current work, increased levels of oxidized glutathione (GSSG) are demonstrated at doses of pyrrolidine dithiocarbamate (PDTC) which decrease SP-A and SP-B mRNAs, suggesting that cellular oxidation reduces surfactant protein expression.	pyrrolidine dithiocarbamic acid	98-125	surfactant protein B	Homo sapiens	157-161
10533675-3	1999	In the current work, increased levels of oxidized glutathione (GSSG) are demonstrated at doses of pyrrolidine dithiocarbamate (PDTC) which decrease SP-A and SP-B mRNAs, suggesting that cellular oxidation reduces surfactant protein expression.	pyrrolidine dithiocarbamic acid	127-131	surfactant protein A1	Homo sapiens	148-152
10533675-3	1999	In the current work, increased levels of oxidized glutathione (GSSG) are demonstrated at doses of pyrrolidine dithiocarbamate (PDTC) which decrease SP-A and SP-B mRNAs, suggesting that cellular oxidation reduces surfactant protein expression.	pyrrolidine dithiocarbamic acid	127-131	surfactant protein B	Homo sapiens	157-161
10416616-8	1999	Induction of NF-kappaB by TNF-alpha was inhibited by the addition of protease inhibitors calpain inhibitor I and N-tosyl-phechloromethyl ketone and antioxidant 1-pyrrolidinecarbodithioic acid, whereas constitutive activation of NF-kappaB and cytokine KC mRNA expression was inhibited by N-tosyl-phechloromethyl ketone alone.	pyrrolidine dithiocarbamic acid	160-191	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-22
10416616-8	1999	Induction of NF-kappaB by TNF-alpha was inhibited by the addition of protease inhibitors calpain inhibitor I and N-tosyl-phechloromethyl ketone and antioxidant 1-pyrrolidinecarbodithioic acid, whereas constitutive activation of NF-kappaB and cytokine KC mRNA expression was inhibited by N-tosyl-phechloromethyl ketone alone.	pyrrolidine dithiocarbamic acid	160-191	tumor necrosis factor	Mus musculus	26-35
10416616-8	1999	Induction of NF-kappaB by TNF-alpha was inhibited by the addition of protease inhibitors calpain inhibitor I and N-tosyl-phechloromethyl ketone and antioxidant 1-pyrrolidinecarbodithioic acid, whereas constitutive activation of NF-kappaB and cytokine KC mRNA expression was inhibited by N-tosyl-phechloromethyl ketone alone.	pyrrolidine dithiocarbamic acid	160-191	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-237
10362686-9	1999	Moreover, the oxygen-induced rise could be mimicked by addition of H2O2 to normoxic cells, and the oxygen-induced expression of VCAM-1 but not of ICAM-1 was inhibited by addition of the free radical scavengers superoxide dismutase, N-acetyl-L-cysteine, and pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	257-283	vascular cell adhesion molecule 1	Homo sapiens	128-134
10549609-1	1999	PURPOSE: The effects of antioxidants (N-acetyl-L-cysteine [NAC] and pyrrolidine dithiocarbamate [PDTC]) on radiation-induced ICAM-1 expression on human umbilical vein endothelial cells (HUVEC) were investigated.	pyrrolidine dithiocarbamic acid	68-95	intercellular adhesion molecule 1	Homo sapiens	125-131
10549609-1	1999	PURPOSE: The effects of antioxidants (N-acetyl-L-cysteine [NAC] and pyrrolidine dithiocarbamate [PDTC]) on radiation-induced ICAM-1 expression on human umbilical vein endothelial cells (HUVEC) were investigated.	pyrrolidine dithiocarbamic acid	97-101	intercellular adhesion molecule 1	Homo sapiens	125-131
10505757-5	1999	Pyrrolidine dithiocarbamate, a potent inhibitor of NF-kappaB activation, attenuated the macrophage TNF-alpha production by PAAF.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	99-108
10446104-9	1999	The cAMP analogues potentiated iNOS at the transcriptional level as shown by effects of actinomycin D (5 microgram/ml) and northern blot analyses; the nuclear factor (NF) kappaB inhibitor, pyrrolidine dithiocarbamate (10-200 microM), significantly reduced this potentiation.	pyrrolidine dithiocarbamic acid	189-216	nitric oxide synthase 2	Homo sapiens	31-35
10446104-9	1999	The cAMP analogues potentiated iNOS at the transcriptional level as shown by effects of actinomycin D (5 microgram/ml) and northern blot analyses; the nuclear factor (NF) kappaB inhibitor, pyrrolidine dithiocarbamate (10-200 microM), significantly reduced this potentiation.	pyrrolidine dithiocarbamic acid	189-216	nuclear factor kappa B subunit 1	Homo sapiens	151-177
10456872-8	1999	Furthermore, the synthetic oligonucleotide-induced expression of this cytokine gene was blocked by pyrrolidine dithiocarbamate and N-acetyl-L-cystine, potent inhibitors of transcriptional factor NF-kappaB.	pyrrolidine dithiocarbamic acid	99-126	nuclear factor kappa B subunit 1	Homo sapiens	195-204
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	16-43	vascular cell adhesion molecule 1	Homo sapiens	71-77
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	16-43	interleukin 4	Homo sapiens	116-120
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	16-43	tumor necrosis factor	Homo sapiens	150-159
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	45-49	vascular cell adhesion molecule 1	Homo sapiens	71-77
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	45-49	interleukin 4	Homo sapiens	116-120
10430178-9	1999	The antioxidant pyrrolidine dithiocarbamate (PDTC) similarly inhibited VCAM-1 upregulation in HASMCs incubated with IL-4 and in HUVECs incubated with TNF-alpha (IC50s of 25 and 40 microM, respectively).	pyrrolidine dithiocarbamic acid	45-49	tumor necrosis factor	Homo sapiens	150-159
10433212-7	1999	Different types of NF-kappaB inhibitors, pyrrolidine dithiocarbamate and MG132, which specifically abolished IkappaB degradation and subsequent NF-kappaB activation by LPS, suppressed TNF alpha secretion from VSMC.	pyrrolidine dithiocarbamic acid	41-68	tumor necrosis factor	Rattus norvegicus	184-193
10433212-10	1999	TNF alpha messenger RNA expression induced by LPS was inhibited by pyrrolidine dithiocarbamate, MG132, and SB203580, but not by PD98059.	pyrrolidine dithiocarbamic acid	67-94	tumor necrosis factor	Rattus norvegicus	0-9
10416602-4	1999	Blocking TNF-alpha expression via treatment with pyrrolidinedithiocarbamate or blocking TNF-alpha activity with neutralizing antibodies abrogated heat-provoked apoptosis.	pyrrolidine dithiocarbamic acid	49-75	tumor necrosis factor	Homo sapiens	9-18
10397679-11	1999	Pyrrolidine dithiocarbamate suppressed angiotensin II-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by angiotensin.	pyrrolidine dithiocarbamic acid	0-27	angiotensinogen	Homo sapiens	39-53
10397679-11	1999	Pyrrolidine dithiocarbamate suppressed angiotensin II-induced IL-6 release, a finding compatible with involvement of reactive oxygen species as second messengers in cytokine production mediated by angiotensin.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	62-66
10405758-2	1999	Pyrrolidine dithiocarbamate (PDTC) has been widely used as an inhibitor of the nuclear factor-kappa B, (NF-kappa B) signalling pathway.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	104-114
10405758-2	1999	Pyrrolidine dithiocarbamate (PDTC) has been widely used as an inhibitor of the nuclear factor-kappa B, (NF-kappa B) signalling pathway.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	104-114
10382751-0	1999	Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Mus musculus	78-87
10382751-2	1999	Here we demonstrate the ability of the antioxidant agent pyrrolidine dithiocarbamate (PDTC) to inhibit the in vivo activation of NF-kappaB in lung and liver tissues, as well as the systemic release of TNF-alpha in lipopolysaccharide (LPS)-treated mice.	pyrrolidine dithiocarbamic acid	57-84	toll-like receptor 4	Mus musculus	234-237
10382751-2	1999	Here we demonstrate the ability of the antioxidant agent pyrrolidine dithiocarbamate (PDTC) to inhibit the in vivo activation of NF-kappaB in lung and liver tissues, as well as the systemic release of TNF-alpha in lipopolysaccharide (LPS)-treated mice.	pyrrolidine dithiocarbamic acid	86-90	tumor necrosis factor	Mus musculus	201-210
10382751-2	1999	Here we demonstrate the ability of the antioxidant agent pyrrolidine dithiocarbamate (PDTC) to inhibit the in vivo activation of NF-kappaB in lung and liver tissues, as well as the systemic release of TNF-alpha in lipopolysaccharide (LPS)-treated mice.	pyrrolidine dithiocarbamic acid	86-90	toll-like receptor 4	Mus musculus	234-237
10336540-4	1999	WEHI 164 cells that had been dually treated with tepoxalin and the antioxidant pyrrolidine dithiocarbamate (PDTC) were significantly protected from TNFalpha-induced killing.	pyrrolidine dithiocarbamic acid	108-112	tumor necrosis factor	Mus musculus	148-156
10216087-7	1999	The cell permeable antioxidant pyrrolidine dithiocarbamate (PDTC) decreased the intracellular levels of ROS and inhibited tyrosine phosphorylation induced by GM-CSF in MO7e cells, suggesting that ROS generation plays an important role in GM-CSF signaling.	pyrrolidine dithiocarbamic acid	31-58	colony stimulating factor 2	Homo sapiens	158-164
10233023-1	1999	In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells.	pyrrolidine dithiocarbamic acid	205-231	interferon gamma	Homo sapiens	45-67
10233023-1	1999	In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells.	pyrrolidine dithiocarbamic acid	205-231	tumor necrosis factor	Homo sapiens	138-171
10216087-7	1999	The cell permeable antioxidant pyrrolidine dithiocarbamate (PDTC) decreased the intracellular levels of ROS and inhibited tyrosine phosphorylation induced by GM-CSF in MO7e cells, suggesting that ROS generation plays an important role in GM-CSF signaling.	pyrrolidine dithiocarbamic acid	31-58	colony stimulating factor 2	Homo sapiens	238-244
10216087-7	1999	The cell permeable antioxidant pyrrolidine dithiocarbamate (PDTC) decreased the intracellular levels of ROS and inhibited tyrosine phosphorylation induced by GM-CSF in MO7e cells, suggesting that ROS generation plays an important role in GM-CSF signaling.	pyrrolidine dithiocarbamic acid	60-64	colony stimulating factor 2	Homo sapiens	158-164
10216087-7	1999	The cell permeable antioxidant pyrrolidine dithiocarbamate (PDTC) decreased the intracellular levels of ROS and inhibited tyrosine phosphorylation induced by GM-CSF in MO7e cells, suggesting that ROS generation plays an important role in GM-CSF signaling.	pyrrolidine dithiocarbamic acid	60-64	colony stimulating factor 2	Homo sapiens	238-244
10202011-7	1999	Finally, both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	pyrrolidine dithiocarbamic acid	35-62	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
10336540-0	1999	Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells.	pyrrolidine dithiocarbamic acid	51-78	tumor necrosis factor	Mus musculus	95-122
10336540-4	1999	WEHI 164 cells that had been dually treated with tepoxalin and the antioxidant pyrrolidine dithiocarbamate (PDTC) were significantly protected from TNFalpha-induced killing.	pyrrolidine dithiocarbamic acid	79-106	tumor necrosis factor	Mus musculus	148-156
10205202-8	1999	iNOS induction and nitrite/nitrate increases were inhibited by dexamethasone and pyrrolidine dithiocarbamate, supporting an important role for the NF-kappaB transcription factor in this process.	pyrrolidine dithiocarbamic acid	81-108	nitric oxide synthase 2	Homo sapiens	0-4
10191209-5	1999	CMV-UV-stimulated IL-6 was inhibited by pyrrolidinedithiocarbamate (an inhibitor of the transcription factor, NF-kappaB) and by pertussis toxin (suggesting the involvement of a G protein) and occurred in the absence of CMV immediate-early antigen transcription.	pyrrolidine dithiocarbamic acid	40-66	interleukin 6	Homo sapiens	18-22
10225421-0	1999	Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor kappa B subunit 1	Homo sapiens	62-71
10225421-1	1999	Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	60-82
10225421-1	1999	Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	84-93
10225421-1	1999	Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	60-82
10225421-1	1999	Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	84-93
10101023-9	1999	Pyrrolidine dithiocarbamate also markedly reduced the LPS-induced tissue myeloperoxidase activity (an indicator of tissue neutrophil retention) and the LPS-induced increase in microvascular permeability in these organs.	pyrrolidine dithiocarbamic acid	0-27	myeloperoxidase	Rattus norvegicus	73-88
10203355-10	1999	Pyrrolidine dithiocarbamate (PDTC), N-acetyl-L-cysteine, dexamethasone (Dex), HerA, and AG490 partially inhibited LPS/ IFN-gamma- or TNF-alpha/IFN-gamma-induced nitrite production.	pyrrolidine dithiocarbamic acid	0-27	interferon gamma	Rattus norvegicus	119-128
10203355-10	1999	Pyrrolidine dithiocarbamate (PDTC), N-acetyl-L-cysteine, dexamethasone (Dex), HerA, and AG490 partially inhibited LPS/ IFN-gamma- or TNF-alpha/IFN-gamma-induced nitrite production.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	133-142
10203355-10	1999	Pyrrolidine dithiocarbamate (PDTC), N-acetyl-L-cysteine, dexamethasone (Dex), HerA, and AG490 partially inhibited LPS/ IFN-gamma- or TNF-alpha/IFN-gamma-induced nitrite production.	pyrrolidine dithiocarbamic acid	0-27	interferon gamma	Rattus norvegicus	143-152
10203355-10	1999	Pyrrolidine dithiocarbamate (PDTC), N-acetyl-L-cysteine, dexamethasone (Dex), HerA, and AG490 partially inhibited LPS/ IFN-gamma- or TNF-alpha/IFN-gamma-induced nitrite production.	pyrrolidine dithiocarbamic acid	29-33	interferon gamma	Rattus norvegicus	119-128
10051436-0	1999	Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels.	pyrrolidine dithiocarbamic acid	0-27	glutamate-cysteine ligase catalytic subunit	Homo sapiens	119-152
10051436-1	1999	Time- and dose-dependent increases in the steady-state mRNA levels of the genes encoding the catalytic and regulatory subunits of the enzyme gamma-glutamylcysteine synthetase (GCS) were observed in HepG2 human hepatocarcinoma cells after exposure to pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	glutamate-cysteine ligase catalytic subunit	Homo sapiens	141-174
10051436-1	1999	Time- and dose-dependent increases in the steady-state mRNA levels of the genes encoding the catalytic and regulatory subunits of the enzyme gamma-glutamylcysteine synthetase (GCS) were observed in HepG2 human hepatocarcinoma cells after exposure to pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	glutamate-cysteine ligase catalytic subunit	Homo sapiens	176-179
10051436-1	1999	Time- and dose-dependent increases in the steady-state mRNA levels of the genes encoding the catalytic and regulatory subunits of the enzyme gamma-glutamylcysteine synthetase (GCS) were observed in HepG2 human hepatocarcinoma cells after exposure to pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	glutamate-cysteine ligase catalytic subunit	Homo sapiens	141-174
10051436-1	1999	Time- and dose-dependent increases in the steady-state mRNA levels of the genes encoding the catalytic and regulatory subunits of the enzyme gamma-glutamylcysteine synthetase (GCS) were observed in HepG2 human hepatocarcinoma cells after exposure to pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	glutamate-cysteine ligase catalytic subunit	Homo sapiens	176-179
10070167-7	1999	Although dexamethasone and pyrrolidinedithiocarbamate (PDTC), inhibitors of nuclear factor-kappaB, inhibited nitrite production, further inhibition by AVP was not observed.	pyrrolidine dithiocarbamic acid	55-59	arginine vasopressin	Rattus norvegicus	151-154
10070049-11	1999	Finally, preincubating cells with pyrrolidinedithiocarbamate (PDTC) but not SN50 (inhibitors of nuclear factor-kappaB activation and nuclear translocation, respectively) attenuated increases in IGFBP-1 induced by IL-1.	pyrrolidine dithiocarbamic acid	34-60	insulin like growth factor binding protein 1	Homo sapiens	194-201
10070049-11	1999	Finally, preincubating cells with pyrrolidinedithiocarbamate (PDTC) but not SN50 (inhibitors of nuclear factor-kappaB activation and nuclear translocation, respectively) attenuated increases in IGFBP-1 induced by IL-1.	pyrrolidine dithiocarbamic acid	34-60	interleukin 1 alpha	Homo sapiens	213-217
10070049-11	1999	Finally, preincubating cells with pyrrolidinedithiocarbamate (PDTC) but not SN50 (inhibitors of nuclear factor-kappaB activation and nuclear translocation, respectively) attenuated increases in IGFBP-1 induced by IL-1.	pyrrolidine dithiocarbamic acid	62-66	insulin like growth factor binding protein 1	Homo sapiens	194-201
10069381-3	1999	In the presence of the antioxidant molecules pyrrolidine dithiocarbamate or 1,10-phenanthroline induction of hsp72 and 27 was significantly decreased, while N-acetyl-L-cysteine caused a slight reduction.	pyrrolidine dithiocarbamic acid	45-72	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-114
9988718-2	1999	Experiments were performed to investigate the involvement of interferon regulatory factor-1 (IRF-1) on NOS-2 induction and its regulation by NOS-2 inhibitors such as pyrrolidine dithiocarbamate (PDTC), an antioxidant, or protein kinase inhibitors.	pyrrolidine dithiocarbamic acid	166-193	interferon regulatory factor 1	Mus musculus	93-98
9988718-2	1999	Experiments were performed to investigate the involvement of interferon regulatory factor-1 (IRF-1) on NOS-2 induction and its regulation by NOS-2 inhibitors such as pyrrolidine dithiocarbamate (PDTC), an antioxidant, or protein kinase inhibitors.	pyrrolidine dithiocarbamic acid	195-199	interferon regulatory factor 1	Mus musculus	93-98
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	pyrrolidine dithiocarbamic acid	265-292	nuclear factor kappa B subunit 1	Homo sapiens	135-144
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	pyrrolidine dithiocarbamic acid	265-292	nuclear factor kappa B subunit 1	Homo sapiens	206-215
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	pyrrolidine dithiocarbamic acid	265-292	nuclear factor kappa B subunit 1	Homo sapiens	206-215
9950856-8	1999	Pyrrolidine dithiocarbamate, an antioxidant, significantly inhibited the loss of IkappaBalpha protein from the cytoplasm and prevented NF-kappaB binding activity in the nucleus.	pyrrolidine dithiocarbamic acid	0-27	NFKB inhibitor alpha	Rattus norvegicus	81-93
9837857-2	1998	We recently characterized the induction of HO-1 gene expression by nitric oxide (NO) and postulated that the addition of an antioxidant, such as pyrrolidine dithiocarbamate (PDTC), would attenuate HO-1 induction in response to NO.	pyrrolidine dithiocarbamic acid	174-178	heme oxygenase 1	Rattus norvegicus	197-201
9922324-8	1999	After blocking of NF-kappaB/Rel activation with pyrrolidine dithiocarbamate, the degree of morphological alterations was more pronounced than in controls, serum amylase and lactate dehydrogenase levels were significantly increased, and messenger RNA levels of pancreatitis-associated protein were more strongly induced, reflecting a more severe degree of pancreatitis.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor kappa B subunit 1	Homo sapiens	18-27
9973408-7	1999	An antioxidant, pyrrolidine dithiocarbamate, which blocked LPS-induced NF-kappaB activation, also abolished the antiapoptotic effects of LPS at the same time.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	71-80
10090397-0	1999	Cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC): response to genistein and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	99-126	nitric oxide synthase 2	Homo sapiens	22-26
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	53-62
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Homo sapiens	97-101
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	0-27	phospholipase A2 group X	Homo sapiens	134-139
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	53-62
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Homo sapiens	97-101
10090397-5	1999	Pyrrolidine dithiocarbamate (PDTC), an inhibitor for NF-kappaB, was more effective in inhibiting iNOS mRNA and NO production than for sPLA2.	pyrrolidine dithiocarbamic acid	29-33	phospholipase A2 group X	Homo sapiens	134-139
9915481-4	1999	We prepared two different NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and NF-kappaB decoy.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor kappa B subunit 1	Homo sapiens	26-35
9915481-4	1999	We prepared two different NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and NF-kappaB decoy.	pyrrolidine dithiocarbamic acid	77-81	nuclear factor kappa B subunit 1	Homo sapiens	26-35
9890996-7	1999	Furthermore, VCAM-1 mRNA induction was inhibited in TNF-alpha-stimulated SMCs, but not in differentiating SMCs, by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB protein activation.	pyrrolidine dithiocarbamic acid	115-142	vascular cell adhesion molecule 1	Homo sapiens	13-19
9890996-7	1999	Furthermore, VCAM-1 mRNA induction was inhibited in TNF-alpha-stimulated SMCs, but not in differentiating SMCs, by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB protein activation.	pyrrolidine dithiocarbamic acid	115-142	tumor necrosis factor	Homo sapiens	52-61
9890996-7	1999	Furthermore, VCAM-1 mRNA induction was inhibited in TNF-alpha-stimulated SMCs, but not in differentiating SMCs, by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB protein activation.	pyrrolidine dithiocarbamic acid	115-142	nuclear factor kappa B subunit 1	Homo sapiens	160-169
9916692-8	1999	The results suggested that TNF activates NF-kappa B through both pyrrolidine dithiocarbamate-sensitive and -insensitive mechanisms.	pyrrolidine dithiocarbamic acid	65-92	tumor necrosis factor	Mus musculus	27-30
9916692-8	1999	The results suggested that TNF activates NF-kappa B through both pyrrolidine dithiocarbamate-sensitive and -insensitive mechanisms.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	41-51
9887050-5	1999	Pyrrolidinedithiocarbamate and the proteasome inhibitor MG-132 blocked TNF- and LPS-stimulated U-937 cell adhesion to HUVECs.	pyrrolidine dithiocarbamic acid	0-26	tumor necrosis factor	Homo sapiens	71-74
9887050-7	1999	TNF increased VCAM-1 protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	68-94	tumor necrosis factor	Homo sapiens	0-3
9887050-7	1999	TNF increased VCAM-1 protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	68-94	vascular cell adhesion molecule 1	Homo sapiens	14-20
10794522-8	1999	Bax and gadd45 gene induction could be efficiently blocked by pretreating the cells with the antioxidant compound pyrrolidine dithiocarbamate, suggesting that oxidative stress was involved in these responses.	pyrrolidine dithiocarbamic acid	114-141	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
10794522-8	1999	Bax and gadd45 gene induction could be efficiently blocked by pretreating the cells with the antioxidant compound pyrrolidine dithiocarbamate, suggesting that oxidative stress was involved in these responses.	pyrrolidine dithiocarbamic acid	114-141	growth arrest and DNA damage inducible alpha	Homo sapiens	8-14
9837857-0	1998	Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	59-86	heme oxygenase 1	Rattus norvegicus	34-50
9837857-2	1998	We recently characterized the induction of HO-1 gene expression by nitric oxide (NO) and postulated that the addition of an antioxidant, such as pyrrolidine dithiocarbamate (PDTC), would attenuate HO-1 induction in response to NO.	pyrrolidine dithiocarbamic acid	145-172	heme oxygenase 1	Rattus norvegicus	43-47
9837857-2	1998	We recently characterized the induction of HO-1 gene expression by nitric oxide (NO) and postulated that the addition of an antioxidant, such as pyrrolidine dithiocarbamate (PDTC), would attenuate HO-1 induction in response to NO.	pyrrolidine dithiocarbamic acid	145-172	heme oxygenase 1	Rattus norvegicus	197-201
9837857-2	1998	We recently characterized the induction of HO-1 gene expression by nitric oxide (NO) and postulated that the addition of an antioxidant, such as pyrrolidine dithiocarbamate (PDTC), would attenuate HO-1 induction in response to NO.	pyrrolidine dithiocarbamic acid	174-178	heme oxygenase 1	Rattus norvegicus	43-47
9833740-8	1998	Pyrrolidine dithiocarbamate, a potent transcriptional inhibitor of the viral LTR, abrogated the cytokine responses in both U1 and ACH-2 cells, suggesting a common TNF-alpha-mediated transcriptional mechanism in these cell types despite their different modes of provirus latency.	pyrrolidine dithiocarbamic acid	0-27	acyl-CoA thioesterase 1	Homo sapiens	130-135
9870552-8	1998	Treatment induced NF-kappaB activation (e.g., wounding, HeNe irradiation and combined wounding and HeNe irradiation) was abrogated by pyrrolidine dithiocarbamate (PDTC) which inhibits NF-kappaB activation through an as yet incompletely understood (antioxidant?)	pyrrolidine dithiocarbamic acid	134-161	nuclear factor kappa B subunit 1	Homo sapiens	18-27
9870552-8	1998	Treatment induced NF-kappaB activation (e.g., wounding, HeNe irradiation and combined wounding and HeNe irradiation) was abrogated by pyrrolidine dithiocarbamate (PDTC) which inhibits NF-kappaB activation through an as yet incompletely understood (antioxidant?)	pyrrolidine dithiocarbamic acid	134-161	nuclear factor kappa B subunit 1	Homo sapiens	184-193
9870552-8	1998	Treatment induced NF-kappaB activation (e.g., wounding, HeNe irradiation and combined wounding and HeNe irradiation) was abrogated by pyrrolidine dithiocarbamate (PDTC) which inhibits NF-kappaB activation through an as yet incompletely understood (antioxidant?)	pyrrolidine dithiocarbamic acid	163-167	nuclear factor kappa B subunit 1	Homo sapiens	18-27
9870552-8	1998	Treatment induced NF-kappaB activation (e.g., wounding, HeNe irradiation and combined wounding and HeNe irradiation) was abrogated by pyrrolidine dithiocarbamate (PDTC) which inhibits NF-kappaB activation through an as yet incompletely understood (antioxidant?)	pyrrolidine dithiocarbamic acid	163-167	nuclear factor kappa B subunit 1	Homo sapiens	184-193
9833740-8	1998	Pyrrolidine dithiocarbamate, a potent transcriptional inhibitor of the viral LTR, abrogated the cytokine responses in both U1 and ACH-2 cells, suggesting a common TNF-alpha-mediated transcriptional mechanism in these cell types despite their different modes of provirus latency.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Homo sapiens	163-172
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	67-94	nuclear factor kappa B subunit 1	Homo sapiens	154-164
9869175-6	1998	We also show that CD40-mediated TF expression is less sensitive to inhibition with the oxidative radical scavenger pyrrolidine dithiocarbamate than is that mediated by TNFalpha, indicating that CD40 has a distinct signalling pathway.	pyrrolidine dithiocarbamic acid	115-142	CD40 molecule	Homo sapiens	18-22
9869175-6	1998	We also show that CD40-mediated TF expression is less sensitive to inhibition with the oxidative radical scavenger pyrrolidine dithiocarbamate than is that mediated by TNFalpha, indicating that CD40 has a distinct signalling pathway.	pyrrolidine dithiocarbamic acid	115-142	coagulation factor III, tissue factor	Homo sapiens	32-34
9869175-6	1998	We also show that CD40-mediated TF expression is less sensitive to inhibition with the oxidative radical scavenger pyrrolidine dithiocarbamate than is that mediated by TNFalpha, indicating that CD40 has a distinct signalling pathway.	pyrrolidine dithiocarbamic acid	115-142	CD40 molecule	Homo sapiens	194-198
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9824162-6	1998	This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC.	pyrrolidine dithiocarbamic acid	308-335	tumor necrosis factor	Homo sapiens	123-126
9824162-6	1998	This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC.	pyrrolidine dithiocarbamic acid	337-341	tumor necrosis factor	Homo sapiens	123-126
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	67-94	E-selectin	Oryctolagus cuniculus	196-206
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	67-94	tumor necrosis factor	Oryctolagus cuniculus	242-275
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	96-100	nuclear factor kappa B subunit 1	Homo sapiens	154-164
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	96-100	E-selectin	Oryctolagus cuniculus	196-206
9792689-10	1998	Pyrrolidinedithiocarbamate (3-30 microM), an inhibitor of NF-kappaB, caused a concentration-dependent reduction in the nitrite response to LPS and UTP.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
9852915-3	1998	METHODS AND RESULTS: In this study, we investigated the ability of pyrrolidine dithiocarbamate (PDTC), an agent that inhibits the nuclear localization of NF-kappa B, to (1) block endothelial cell E-selectin expression in vitro in response to tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and lipopolysaccharide (LPS) and (2) reduce neutrophil infiltration in a rabbit model of systemic inflammation.	pyrrolidine dithiocarbamic acid	96-100	tumor necrosis factor	Oryctolagus cuniculus	242-275
9820155-4	1998	The effect of HSV-2 on NF-kappaB and NO production was eliminated when cells were treated with antibodies to TNF-alpha, and direct inhibition of NF-kappaB activation with pyrrolidinedithiocarbamate (PDTC) also blocked the effect of HSV-2 infection on NO production.	pyrrolidine dithiocarbamic acid	171-197	nuclear factor kappa B subunit 1	Homo sapiens	23-32
9792910-6	1998	Inhibition by pyrrolidine dithiocarbamate, a NF-kappaB/c-rel inhibitor, further implies the involvement of NF-kappaB/c-rel.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	45-54
9792910-6	1998	Inhibition by pyrrolidine dithiocarbamate, a NF-kappaB/c-rel inhibitor, further implies the involvement of NF-kappaB/c-rel.	pyrrolidine dithiocarbamic acid	14-41	reticuloendotheliosis oncogene	Mus musculus	55-60
9792910-6	1998	Inhibition by pyrrolidine dithiocarbamate, a NF-kappaB/c-rel inhibitor, further implies the involvement of NF-kappaB/c-rel.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
9792910-6	1998	Inhibition by pyrrolidine dithiocarbamate, a NF-kappaB/c-rel inhibitor, further implies the involvement of NF-kappaB/c-rel.	pyrrolidine dithiocarbamic acid	14-41	reticuloendotheliosis oncogene	Mus musculus	117-122
9820155-4	1998	The effect of HSV-2 on NF-kappaB and NO production was eliminated when cells were treated with antibodies to TNF-alpha, and direct inhibition of NF-kappaB activation with pyrrolidinedithiocarbamate (PDTC) also blocked the effect of HSV-2 infection on NO production.	pyrrolidine dithiocarbamic acid	171-197	nuclear factor kappa B subunit 1	Homo sapiens	145-154
9820155-4	1998	The effect of HSV-2 on NF-kappaB and NO production was eliminated when cells were treated with antibodies to TNF-alpha, and direct inhibition of NF-kappaB activation with pyrrolidinedithiocarbamate (PDTC) also blocked the effect of HSV-2 infection on NO production.	pyrrolidine dithiocarbamic acid	199-203	nuclear factor kappa B subunit 1	Homo sapiens	145-154
9806591-3	1998	The levels of all three mRNAs were increased 1 h after irradiation, with elevated expression persisting for at least 24 h. Similar to radiation, other oxidants lead to induction of MTCO1, an effect which could be prevented by the antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	242-269	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	181-186
9756946-5	1998	Tumor necrosis factor alpha inhibits CYP1A1 expression, and this inhibition is prevented by the antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	108-135	tumor necrosis factor	Homo sapiens	0-27
9756946-5	1998	Tumor necrosis factor alpha inhibits CYP1A1 expression, and this inhibition is prevented by the antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	108-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43
9788894-6	1998	.NO production and iNOS protein expression by both macrophages and epithelial cells were blocked by pyrrolidine dithiocarbamate (PDTC), an agent that inhibits activity of nuclear transcription factor kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	100-127	nitric oxide synthase 2	Rattus norvegicus	19-23
9788894-6	1998	.NO production and iNOS protein expression by both macrophages and epithelial cells were blocked by pyrrolidine dithiocarbamate (PDTC), an agent that inhibits activity of nuclear transcription factor kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	129-133	nitric oxide synthase 2	Rattus norvegicus	19-23
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	pyrrolidine dithiocarbamic acid	70-96	prostaglandin I2 synthase	Homo sapiens	7-11
9728048-3	1998	Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression.	pyrrolidine dithiocarbamic acid	47-74	tumor necrosis factor	Homo sapiens	102-111
9728048-3	1998	Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression.	pyrrolidine dithiocarbamic acid	47-74	selectin E	Homo sapiens	177-187
9728048-3	1998	Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression.	pyrrolidine dithiocarbamic acid	76-80	tumor necrosis factor	Homo sapiens	102-111
9728048-3	1998	Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) for 0.5 h inhibited TNF-alpha-induced generation of ROS as well as activation of NF-kappaB and E-selectin mRNA and the cell surface protein expression.	pyrrolidine dithiocarbamic acid	76-80	selectin E	Homo sapiens	177-187
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	pyrrolidine dithiocarbamic acid	70-96	interleukin 1 beta	Homo sapiens	154-162
9721692-15	1998	in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees.	pyrrolidine dithiocarbamic acid	70-96	prostaglandin I2 synthase	Homo sapiens	166-170
9668066-0	1998	Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.	pyrrolidine dithiocarbamic acid	0-27	tumor protein p53	Homo sapiens	37-40
9668066-0	1998	Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.	pyrrolidine dithiocarbamic acid	0-27	tumor protein p53	Homo sapiens	65-68
9688852-2	1998	Experiments were performed to investigate the effects of tyrosine kinase inhibitors (genistein and herbimycin A) and antioxidants [pyrrolidine dithiocarbamate (PDTC) and butyl hydroxyanisol] on NOS-II induction.	pyrrolidine dithiocarbamic acid	131-158	nitric oxide synthase 2	Bos taurus	194-200
9647253-7	1998	In mesangial cells, AngII activated NF-kappaB (4.3-fold), and the NF-kappaB inhibitor pyrrolidine dithiocarbamate abolished the AngII-induced NF-kappaB activation and MCP-1 gene expression.	pyrrolidine dithiocarbamic acid	86-113	angiotensinogen	Rattus norvegicus	128-133
10200517-5	1998	The pre-treatment of cells with specific inhibitors of these proteins [pyrrolidine dithiocarbamate (NF-kappaB inhibitor) and 3-aminobenzamide (PARP inhibitor)] sensitizes cells to the induction of apoptosis by NaDOC, indicating that these stress response pathways are protective in nature.	pyrrolidine dithiocarbamic acid	71-98	nuclear factor kappa B subunit 1	Homo sapiens	100-109
9647253-7	1998	In mesangial cells, AngII activated NF-kappaB (4.3-fold), and the NF-kappaB inhibitor pyrrolidine dithiocarbamate abolished the AngII-induced NF-kappaB activation and MCP-1 gene expression.	pyrrolidine dithiocarbamic acid	86-113	C-C motif chemokine ligand 2	Rattus norvegicus	167-172
9688083-2	1998	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activity, was used to determine the role of this transcription factor in our model of stress-induced endothelial cell apoptosis.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	52-61
9688083-2	1998	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activity, was used to determine the role of this transcription factor in our model of stress-induced endothelial cell apoptosis.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	52-61
9688091-0	1998	Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin.	pyrrolidine dithiocarbamic acid	0-27	interleukin 10	Mus musculus	37-42
9688091-0	1998	Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Mus musculus	53-62
9688091-0	1998	Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin.	pyrrolidine dithiocarbamic acid	0-27	chemokine (C-C motif) ligand 3	Mus musculus	64-74
9620068-10	1998	Furthermore, pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB activation, prevented the induction of the IL-8 gene, but not that of the VEGF gene.	pyrrolidine dithiocarbamic acid	13-40	nuclear factor kappa B subunit 1	Homo sapiens	66-75
9614147-6	1998	We show that inhibition of NF-kappaB by pyrrolidinedithiocarbamate prevents poly(I-C) + IFN-gamma-, poly(I-C) + LPS-, and LPS-induced iNOS expression, nitrite production and IkappaB degradation by RAW 264.7 cells.	pyrrolidine dithiocarbamic acid	40-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
9614147-6	1998	We show that inhibition of NF-kappaB by pyrrolidinedithiocarbamate prevents poly(I-C) + IFN-gamma-, poly(I-C) + LPS-, and LPS-induced iNOS expression, nitrite production and IkappaB degradation by RAW 264.7 cells.	pyrrolidine dithiocarbamic acid	40-66	interferon gamma	Mus musculus	88-97
9614147-6	1998	We show that inhibition of NF-kappaB by pyrrolidinedithiocarbamate prevents poly(I-C) + IFN-gamma-, poly(I-C) + LPS-, and LPS-induced iNOS expression, nitrite production and IkappaB degradation by RAW 264.7 cells.	pyrrolidine dithiocarbamic acid	40-66	nitric oxide synthase 2, inducible	Mus musculus	134-138
9614147-9	1998	In addition, we show that the combination of poly(I-C) + IFN-gamma stimulates iNOS expression, nitrite production, IkappaB degradation, and the release of IL-1 by primary mouse macrophages, and these effects are prevented by pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	225-251	interferon gamma	Mus musculus	57-66
9614147-9	1998	In addition, we show that the combination of poly(I-C) + IFN-gamma stimulates iNOS expression, nitrite production, IkappaB degradation, and the release of IL-1 by primary mouse macrophages, and these effects are prevented by pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	225-251	interleukin 1 complex	Mus musculus	155-159
9654343-6	1998	The antioxidant pyrrolidine dithiocarbamate and the proteasome inhibitor, n-Tosyl-Phe-chloromethyl ketone, blocked both the activation of NF-kappaB and the upregulation of the ICAM-1 gene.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	138-147
9654343-6	1998	The antioxidant pyrrolidine dithiocarbamate and the proteasome inhibitor, n-Tosyl-Phe-chloromethyl ketone, blocked both the activation of NF-kappaB and the upregulation of the ICAM-1 gene.	pyrrolidine dithiocarbamic acid	16-43	intercellular adhesion molecule 1	Homo sapiens	176-182
9620068-10	1998	Furthermore, pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB activation, prevented the induction of the IL-8 gene, but not that of the VEGF gene.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
9620307-8	1998	Phosphorylation of EGFR was inhibited by the structurally unrelated antioxidants butylated hydroxyanisole, N-acetyl-L-cysteine, and pyrrolidine dithiocarbamate, or by the H2O2-degrading enzyme catalase.	pyrrolidine dithiocarbamic acid	132-159	epidermal growth factor receptor	Homo sapiens	19-23
9607191-10	1998	The NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC; 25 microM) and sodium salicylate (10 mM) significantly reduced BSA-induced RANTES production.	pyrrolidine dithiocarbamic acid	26-53	C-C motif chemokine 5	Sus scrofa	136-142
9607191-10	1998	The NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC; 25 microM) and sodium salicylate (10 mM) significantly reduced BSA-induced RANTES production.	pyrrolidine dithiocarbamic acid	55-59	C-C motif chemokine 5	Sus scrofa	136-142
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	nuclear factor kappa B subunit 1	Homo sapiens	0-9
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	nuclear factor kappa B subunit 1	Homo sapiens	105-114
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	interleukin 1 beta	Homo sapiens	144-152
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	nuclear factor kappa B subunit 1	Homo sapiens	86-95
9593751-11	1998	The antioxidant pyrrolidine dithiocarbamate also suppressed constitutive NF-kappaB activation and it reversed the cell"s sensitivity to TNF-induced cytotoxicity and activation of caspase-3.	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	73-82
9593751-11	1998	The antioxidant pyrrolidine dithiocarbamate also suppressed constitutive NF-kappaB activation and it reversed the cell"s sensitivity to TNF-induced cytotoxicity and activation of caspase-3.	pyrrolidine dithiocarbamic acid	16-43	tumor necrosis factor	Homo sapiens	136-139
9593751-11	1998	The antioxidant pyrrolidine dithiocarbamate also suppressed constitutive NF-kappaB activation and it reversed the cell"s sensitivity to TNF-induced cytotoxicity and activation of caspase-3.	pyrrolidine dithiocarbamic acid	16-43	caspase 3	Homo sapiens	179-188
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	bradykinin receptor B1	Homo sapiens	118-129
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	interleukin 1 beta	Homo sapiens	168-176
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	bradykinin receptor B1	Homo sapiens	194-205
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	nuclear factor kappa B subunit 1	Homo sapiens	253-262
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	bradykinin receptor B1	Homo sapiens	194-205
9593764-10	1998	This correlation was further confirmed by reporter gene assays which showed that this NF-kappaB-like sequence, in the B1-receptor promoter context, could contribute to IL-1beta and DLBK-induced B1-receptor transcription activation, and by the effect of NF-kappaB inhibitor pyrrolidinedithiocarbamate which diminished both B1-receptor upregulation and NF-kappaB activation.	pyrrolidine dithiocarbamic acid	273-299	nuclear factor kappa B subunit 1	Homo sapiens	253-262
9516402-6	1998	Pretreatment of the cells with pyrrolidine dithiocarbamate completely abolished PAP-I mRNA induction, suggesting involvement of NFkappaB in the signaling pathway.	pyrrolidine dithiocarbamic acid	31-58	annexin A5	Rattus norvegicus	80-85
9523575-5	1998	Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances.	pyrrolidine dithiocarbamic acid	24-50	interleukin 1 beta	Homo sapiens	76-84
9523575-5	1998	Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances.	pyrrolidine dithiocarbamic acid	24-50	interleukin 6	Homo sapiens	93-97
9446561-9	1998	Inhibition of ceramide and LPS-mediated induction of iNOS by antioxidant inhibitors of NF-kappaB (N-acetylcysteine and pyrrolidine dithiocarbamate) suggest that the stimulatory effect of ceramide on the induction of iNOS is due to the stimulation of NF-kappaB activation and that cellular redox plays a role in the activation of NF-kappaB and induction of iNOS.	pyrrolidine dithiocarbamic acid	119-146	nitric oxide synthase 2	Rattus norvegicus	53-57
9531254-7	1998	The role of redox-sensitive mechanisms in this process was further supported by the observation that HNE-induced DNA synthesis and AP-1 activation were inhibited by the antioxidants N-acetylcysteine and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	203-230	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-135
9600638-6	1998	Pyrrolidine dithiocarbamate (1-pyrrolidinecarbodithioic acid) (100 microM), an inhibitor of nuclear factor kappaB (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	115-124
9600638-6	1998	Pyrrolidine dithiocarbamate (1-pyrrolidinecarbodithioic acid) (100 microM), an inhibitor of nuclear factor kappaB (NF-kappaB) activation.	pyrrolidine dithiocarbamic acid	29-60	nuclear factor kappa B subunit 1	Homo sapiens	115-124
9507734-10	1998	Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.	pyrrolidine dithiocarbamic acid	77-103	nuclear factor kappa B subunit 1	Homo sapiens	55-65
9507734-10	1998	Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.	pyrrolidine dithiocarbamic acid	105-109	nuclear factor kappa B subunit 1	Homo sapiens	55-65
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	70-97	Fc epsilon receptor II	Rattus norvegicus	219-223
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	70-97	nitric oxide synthase 2	Rattus norvegicus	128-132
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	70-97	nitric oxide synthase 2	Rattus norvegicus	349-353
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	99-103	nitric oxide synthase 2	Rattus norvegicus	128-132
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	99-103	Fc epsilon receptor II	Rattus norvegicus	219-223
9464257-4	1998	Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-kappa B activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab")2, thus suggesting the involvement of NF-kappa B in the signaling pathway leading to the transcriptional activation of iNOS.	pyrrolidine dithiocarbamic acid	99-103	nitric oxide synthase 2	Rattus norvegicus	349-353
9458713-7	1998	Pyrrolidinedithiocarbamate, genistein, and 7-amino-1-chloro-3-tosylamido-2-hepatanone, compounds that can inhibit NF-kappa B activation, partially prevented the TNF-alpha-induced decrease in myo-inositol accumulation.	pyrrolidine dithiocarbamic acid	0-26	tumor necrosis factor	Bos taurus	161-170
9400371-4	1997	H-89, dexamethasone, herbimycin, genistein, staurosporine, or pyrrolidine dithiocarbamate (PDTC) attenuated the iNOS induction by LPS.	pyrrolidine dithiocarbamic acid	62-89	nitric oxide synthase 2	Rattus norvegicus	112-116
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	35-62	superoxide dismutase 2	Homo sapiens	102-107
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	35-62	nuclear factor kappa B subunit 1	Homo sapiens	169-179
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	35-62	NFKB inhibitor alpha	Homo sapiens	202-217
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	64-68	superoxide dismutase 2	Homo sapiens	102-107
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	64-68	nuclear factor kappa B subunit 1	Homo sapiens	169-179
9434740-5	1997	The metal chelator and antioxidant pyrrolidine dithiocarbamate (PDTC) at 60 or 100 microM induced the MnSOD transcript in HeLa cells while diminishing expression of the NF kappa B-responsive transcript I kappa B-alpha.	pyrrolidine dithiocarbamic acid	64-68	NFKB inhibitor alpha	Homo sapiens	202-217
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	pyrrolidine dithiocarbamic acid	117-121	superoxide dismutase 2	Homo sapiens	17-22
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	pyrrolidine dithiocarbamic acid	117-121	nuclear factor kappa B subunit 1	Homo sapiens	179-189
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	pyrrolidine dithiocarbamic acid	117-121	NFKB inhibitor alpha	Homo sapiens	211-226
9400371-4	1997	H-89, dexamethasone, herbimycin, genistein, staurosporine, or pyrrolidine dithiocarbamate (PDTC) attenuated the iNOS induction by LPS.	pyrrolidine dithiocarbamic acid	91-95	nitric oxide synthase 2	Rattus norvegicus	112-116
9343406-5	1997	Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1.	pyrrolidine dithiocarbamic acid	74-89	nuclear factor of activated T cells 2	Homo sapiens	122-126
9394832-9	1997	Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.	pyrrolidine dithiocarbamic acid	48-75	interleukin 1 receptor, type I	Mus musculus	175-181
9394832-9	1997	Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.	pyrrolidine dithiocarbamic acid	77-81	interleukin 1 receptor, type I	Mus musculus	175-181
9450660-0	1997	Pyrrolidine dithiocarbamate inhibits cytokine-induced VCAM-1 gene expression in rat cardiac myocytes.	pyrrolidine dithiocarbamic acid	0-27	vascular cell adhesion molecule 1	Rattus norvegicus	54-60
9450660-4	1997	Induction of VCAM-1 gene expression in response to IL-1 and IFN was antagonized in a concentration-dependent manner by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa b activation (25-100 microM).	pyrrolidine dithiocarbamic acid	119-146	vascular cell adhesion molecule 1	Rattus norvegicus	13-19
9450660-4	1997	Induction of VCAM-1 gene expression in response to IL-1 and IFN was antagonized in a concentration-dependent manner by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa b activation (25-100 microM).	pyrrolidine dithiocarbamic acid	119-146	interferon gamma	Rattus norvegicus	60-63
9343406-5	1997	Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1.	pyrrolidine dithiocarbamic acid	91-95	nuclear factor of activated T cells 2	Homo sapiens	122-126
9325328-7	1997	However, we found that tumor necrosis factor- but not interleukin-1-driven NF-kappaB activation and IkappaBalpha degradation were sensitive to pyrrolidine dithiocarbamate in transformed cells, while neither pathway was inhibited in primary cells.	pyrrolidine dithiocarbamic acid	143-170	tumor necrosis factor	Homo sapiens	23-44
9378986-4	1997	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	146-150
9378986-4	1997	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	187-191
9378986-4	1997	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Rattus norvegicus	146-150
9378986-4	1997	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B effective in cellular studies, prevented NF-kappa B activation in vivo and reduced iNOS mRNA expression and the increase in iNOS activity activated by LPS.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Rattus norvegicus	187-191
9351352-4	1997	This activation of NF-kappa B was inhibited by the antioxidant and H2O2 scavenger pyrrolidine dithiocarbamate and the proteasome inhibitor PSI.	pyrrolidine dithiocarbamic acid	82-109	nuclear factor kappa B subunit 1	Homo sapiens	19-29
9315628-3	1997	To address this question, we have analyzed the effect of pyrrolidine dithiocarbamate (PDTC) on p53 DNA-binding activity in cell lines expressing wild-type p53.	pyrrolidine dithiocarbamic acid	57-84	tumor protein p53	Homo sapiens	95-98
9315628-3	1997	To address this question, we have analyzed the effect of pyrrolidine dithiocarbamate (PDTC) on p53 DNA-binding activity in cell lines expressing wild-type p53.	pyrrolidine dithiocarbamic acid	86-90	tumor protein p53	Homo sapiens	95-98
9268159-3	1997	N-Acetylcysteine (NAC), pyrrolidinedithiocarbamate (PDTC), and Trimidox (TD) at various concentrations inhibited TNF-alpha-induced NF-kappaB binding in Jurkat cells.	pyrrolidine dithiocarbamic acid	24-50	tumor necrosis factor	Homo sapiens	113-122
9268159-3	1997	N-Acetylcysteine (NAC), pyrrolidinedithiocarbamate (PDTC), and Trimidox (TD) at various concentrations inhibited TNF-alpha-induced NF-kappaB binding in Jurkat cells.	pyrrolidine dithiocarbamic acid	52-56	tumor necrosis factor	Homo sapiens	113-122
9277499-4	1997	Unlike published studies with pyrrolidinedithiocarbamate, which specifically inhibited vascular cell adhesion molecule 1 (VCAM-1), NAC inhibited IL-1 beta-induced mRNA and cell surface expression of both E-selectin and VCAM-1.	pyrrolidine dithiocarbamic acid	30-56	vascular cell adhesion molecule 1	Homo sapiens	122-128
9263993-13	1997	In contrast, cytokines in combination with pyrrolidine dithiocarbamate, which blocks endogenous superoxide dismutase, allowed p53 and Bax accumulation as well as DNA fragmentation.	pyrrolidine dithiocarbamic acid	43-70	tumor protein p53	Homo sapiens	126-129
9263993-13	1997	In contrast, cytokines in combination with pyrrolidine dithiocarbamate, which blocks endogenous superoxide dismutase, allowed p53 and Bax accumulation as well as DNA fragmentation.	pyrrolidine dithiocarbamic acid	43-70	BCL2 associated X, apoptosis regulator	Homo sapiens	134-137
9278255-9	1997	In the same system, the antioxidants, N-acetyl-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) at concentrations shown to up-regulate the mRNAs of both c-jun and c-fos, also enhance the transactivity of AP-1.	pyrrolidine dithiocarbamic acid	95-99	transcription factor Jun	Oryctolagus cuniculus	158-163
9176395-9	1997	Preincubation of HUVECs with pyrrolidine dithiocarbamate prevented MAC-induced increases in IL-8 and MCP-1 mRNA concentrations and protein secretion.	pyrrolidine dithiocarbamic acid	29-56	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9176395-9	1997	Preincubation of HUVECs with pyrrolidine dithiocarbamate prevented MAC-induced increases in IL-8 and MCP-1 mRNA concentrations and protein secretion.	pyrrolidine dithiocarbamic acid	29-56	C-C motif chemokine ligand 2	Homo sapiens	101-106
9144512-17	1997	Moreover, pyrrolidine dithiocarbamate supplementation, which down-regulates iNOS expression and blocks superoxide dismutase activity, initiates apoptosis.	pyrrolidine dithiocarbamic acid	10-37	nitric oxide synthase 2	Rattus norvegicus	76-80
9122255-5	1997	Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of NF kappaB in most cells; however, we show that PDTC is also a potent scavenger of NO through formation of mononitrosyl iron complexes with PDTC.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	54-63
9122255-5	1997	Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of NF kappaB in most cells; however, we show that PDTC is also a potent scavenger of NO through formation of mononitrosyl iron complexes with PDTC.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	54-63
9048649-10	1997	Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs.	pyrrolidine dithiocarbamic acid	129-155	selectin E	Homo sapiens	13-23
9048649-10	1997	Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs.	pyrrolidine dithiocarbamic acid	129-155	tumor necrosis factor	Homo sapiens	54-63
9048649-10	1997	Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs.	pyrrolidine dithiocarbamic acid	129-155	selectin E	Homo sapiens	329-339
9119025-5	1997	Cell-to-cell contact activation of NF-kappaB was only partially inhibited by 100 microM pyrrolidine dithiocarbamate and was not correlated with a significant decrease of cellular inhibitor kappaB alpha.	pyrrolidine dithiocarbamic acid	88-115	nuclear factor kappa B subunit 1	Homo sapiens	35-44
9325328-6	1997	Pyrrolidine dithiocarbamate has been purported to be a specific antioxidant inhibitor of NF-kappaB that acts independently of activating agent or cell type.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	89-98
9317146-9	1997	MC pretreatment with the antioxidant pyrrolidine dithiocarbamate inhibited NF-kappa B activation and chemokine mRNA expression.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	75-85
9331934-5	1997	This IL-1-induced activation of astrocyte iNOS was suppressed by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa B activation, suggesting involvement of a NF-kappa B mechanism.	pyrrolidine dithiocarbamic acid	65-92	nitric oxide synthase 2	Homo sapiens	42-46
9331934-5	1997	This IL-1-induced activation of astrocyte iNOS was suppressed by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa B activation, suggesting involvement of a NF-kappa B mechanism.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor kappa B subunit 1	Homo sapiens	110-120
9331934-5	1997	This IL-1-induced activation of astrocyte iNOS was suppressed by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa B activation, suggesting involvement of a NF-kappa B mechanism.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor kappa B subunit 1	Homo sapiens	161-171
9306134-15	1997	Indeed, addition of inhibitors of NF-kappa B activation pyrrolidine dithiocarbamate (PDTC), to the lymphocytes of the chemically-exposed group was capable of inhibiting programmed cell death by 40%.	pyrrolidine dithiocarbamic acid	56-83	nuclear factor kappa B subunit 1	Homo sapiens	34-44
9306134-15	1997	Indeed, addition of inhibitors of NF-kappa B activation pyrrolidine dithiocarbamate (PDTC), to the lymphocytes of the chemically-exposed group was capable of inhibiting programmed cell death by 40%.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	34-44
9378759-7	1997	Pyrrolidine dithiocarbamate and N-acetyl-leucinyl-leucinyl-norleucinal H (two compounds that differentially inhibit I kappa B alpha degradation and, thus, NF-kappa B activation) reversed the insulin-stimulated keratinocyte haptotactic migration without affecting insulin receptor activation.	pyrrolidine dithiocarbamic acid	0-27	NFKB inhibitor alpha	Homo sapiens	116-131
9378759-7	1997	Pyrrolidine dithiocarbamate and N-acetyl-leucinyl-leucinyl-norleucinal H (two compounds that differentially inhibit I kappa B alpha degradation and, thus, NF-kappa B activation) reversed the insulin-stimulated keratinocyte haptotactic migration without affecting insulin receptor activation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	155-165
9378759-7	1997	Pyrrolidine dithiocarbamate and N-acetyl-leucinyl-leucinyl-norleucinal H (two compounds that differentially inhibit I kappa B alpha degradation and, thus, NF-kappa B activation) reversed the insulin-stimulated keratinocyte haptotactic migration without affecting insulin receptor activation.	pyrrolidine dithiocarbamic acid	0-27	insulin	Homo sapiens	191-198
9378759-7	1997	Pyrrolidine dithiocarbamate and N-acetyl-leucinyl-leucinyl-norleucinal H (two compounds that differentially inhibit I kappa B alpha degradation and, thus, NF-kappa B activation) reversed the insulin-stimulated keratinocyte haptotactic migration without affecting insulin receptor activation.	pyrrolidine dithiocarbamic acid	0-27	insulin	Homo sapiens	263-270
9270030-6	1997	Pyrrolidine dithiocarbamate, an antioxidant that acts as an NF-kappaB inhibitor, efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA) or TNF-alpha induced NF-kappaB as well as AP-1 transactivation and cell transformation, suggesting dependency of transformation on both transcription factors.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Mus musculus	149-158
9278255-9	1997	In the same system, the antioxidants, N-acetyl-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) at concentrations shown to up-regulate the mRNAs of both c-jun and c-fos, also enhance the transactivity of AP-1.	pyrrolidine dithiocarbamic acid	66-93	transcription factor Jun	Oryctolagus cuniculus	158-163
9218608-4	1997	However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself.	pyrrolidine dithiocarbamic acid	156-183	nitric oxide synthase 2	Rattus norvegicus	27-31
9218608-4	1997	However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself.	pyrrolidine dithiocarbamic acid	156-183	C-X-C motif chemokine ligand 1	Rattus norvegicus	36-42
9218608-4	1997	However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself.	pyrrolidine dithiocarbamic acid	185-189	nitric oxide synthase 2	Rattus norvegicus	27-31
9218608-4	1997	However, the expression of iNOS and CINC-1 mRNA induced by IC showed a different temporal pattern and a different sensitivity to both the antioxidant agent pyrrolidine dithiocarbamate (PDTC) and modulation by NO itself.	pyrrolidine dithiocarbamic acid	185-189	C-X-C motif chemokine ligand 1	Rattus norvegicus	36-42
9483174-3	1997	Scavengers of reactive oxygen intermediates such as N-acetyl cysteine or pyrrolidine dithiocarbamate were able to block TF induction.	pyrrolidine dithiocarbamic acid	73-100	coagulation factor III, tissue factor	Homo sapiens	120-122
9188453-9	1997	For example, the p21(ras).GTP loading, p44 MAPK activity, and induction of transcription factor c-fos all were inhibited by NAC and DPI as well as an antioxidant pyrrolidine dithiocarbamate or reduced glutathione (GSH).	pyrrolidine dithiocarbamic acid	162-189	H3 histone pseudogene 16	Homo sapiens	17-20
9188453-9	1997	For example, the p21(ras).GTP loading, p44 MAPK activity, and induction of transcription factor c-fos all were inhibited by NAC and DPI as well as an antioxidant pyrrolidine dithiocarbamate or reduced glutathione (GSH).	pyrrolidine dithiocarbamic acid	162-189	mitogen-activated protein kinase 3	Homo sapiens	43-47
9188453-9	1997	For example, the p21(ras).GTP loading, p44 MAPK activity, and induction of transcription factor c-fos all were inhibited by NAC and DPI as well as an antioxidant pyrrolidine dithiocarbamate or reduced glutathione (GSH).	pyrrolidine dithiocarbamic acid	162-189	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-101
9148901-10	1997	A structurally related compound, mitoxantrone, which, unlike daunorubicin, is unable to undergo redox cycling in cells, also activated NFkappaB in a pyrrolidine dithiocarbamate-sensitive manner.	pyrrolidine dithiocarbamic acid	149-176	nuclear factor kappa B subunit 1	Homo sapiens	135-143
9105716-10	1997	The production of NO by retro-inverso CRP-peptide analogues was significantly inhibited by dexamethasone (20 microM), NG-monomethyl-L-arginine (L-NMMA) (500 microM) and pyrrolidine dithiocarbamate (PDTC) (100 microM).	pyrrolidine dithiocarbamic acid	169-196	C-reactive protein, pentraxin-related	Mus musculus	38-41
9105716-10	1997	The production of NO by retro-inverso CRP-peptide analogues was significantly inhibited by dexamethasone (20 microM), NG-monomethyl-L-arginine (L-NMMA) (500 microM) and pyrrolidine dithiocarbamate (PDTC) (100 microM).	pyrrolidine dithiocarbamic acid	198-202	C-reactive protein, pentraxin-related	Mus musculus	38-41
9195048-1	1997	The induction of JE/MCP-1 gene by TPA was transcriptionally suppressed by antioxidants such as pyrrolidine dithiocarbamate (PDTC) or trimethylthiourea (TMTU) in Balb 3T3 cells, whereas that of other early response genes, c-fos or egr-1, was not affected by these agents.	pyrrolidine dithiocarbamic acid	95-122	chemokine (C-C motif) ligand 2	Mus musculus	20-25
9195048-1	1997	The induction of JE/MCP-1 gene by TPA was transcriptionally suppressed by antioxidants such as pyrrolidine dithiocarbamate (PDTC) or trimethylthiourea (TMTU) in Balb 3T3 cells, whereas that of other early response genes, c-fos or egr-1, was not affected by these agents.	pyrrolidine dithiocarbamic acid	124-128	chemokine (C-C motif) ligand 2	Mus musculus	20-25
9118522-10	1997	Ang II elicited an increase in NF-kappa B activation and MCP-1 expression that was prevented by preincubation of cells with pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B activation.	pyrrolidine dithiocarbamic acid	124-150	C-C motif chemokine 2	Oryctolagus cuniculus	57-62
9062344-10	1997	Pyrrolidine dithiocarbamate, an inhibitor of oxidative NF-kappaB activation, diphenylene iodonium, an NADPH oxidase inhibitor, and quinacrine, a phospholipase A2 inhibitor, significantly attenuated the increase in dichlorofluorescein fluorescence, NF-kappaB activation, and NO production.	pyrrolidine dithiocarbamic acid	0-27	phospholipase A2 group IB	Rattus norvegicus	145-161
9325328-10	1997	This suggested that pyrrolidine dithiocarbamate was inhibiting NF-kappaB activation in endothelial cells primarily through its iron-chelating properties.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor kappa B subunit 1	Homo sapiens	63-72
9032466-6	1997	Various antioxidants, such as pyrrolidine dithiocarbamate, p-bromophenacyl-bromide and nordihydroguaiaretic acid could strongly reduce NF-kappaB translocation, demonstrating the importance of oxidative species in the transduction mechanism.	pyrrolidine dithiocarbamic acid	30-57	nuclear factor kappa B subunit 1	Homo sapiens	135-144
9235225-5	1997	Low environmental pH-induced iNOS gene expression involved the activation of nuclear factor-kappa B (NF-kappa B) transcription factor since [1] exposure of macrophages to low environmental pH increased NF-kappa B binding activity in the nucleus, and [2] treatment of macrophages with pyrrolidine dithiocarbamate or n-acetyl-leucinyl-norleucinal, two drugs preventing NF-kappa B translocation to the nucleus, canceled low pH-induced nitrite accumulation.	pyrrolidine dithiocarbamic acid	284-311	nitric oxide synthase 2	Rattus norvegicus	29-33
9057838-6	1997	Moreover, known inhibitors of NF-kappa B activation, such as dexamethasone and the antioxidant pyrrolidine dithiocarbamate, as well as the protein kinase C (PKC) inhibitor Go6976, strongly reduced lipopolysaccharide-induced COX-2 transcription, indicating the involvement of NF-kappa B and PKC in COX-2 expression.	pyrrolidine dithiocarbamic acid	95-122	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	224-229
9057838-6	1997	Moreover, known inhibitors of NF-kappa B activation, such as dexamethasone and the antioxidant pyrrolidine dithiocarbamate, as well as the protein kinase C (PKC) inhibitor Go6976, strongly reduced lipopolysaccharide-induced COX-2 transcription, indicating the involvement of NF-kappa B and PKC in COX-2 expression.	pyrrolidine dithiocarbamic acid	95-122	protein kinase C, gamma	Rattus norvegicus	290-293
9057838-6	1997	Moreover, known inhibitors of NF-kappa B activation, such as dexamethasone and the antioxidant pyrrolidine dithiocarbamate, as well as the protein kinase C (PKC) inhibitor Go6976, strongly reduced lipopolysaccharide-induced COX-2 transcription, indicating the involvement of NF-kappa B and PKC in COX-2 expression.	pyrrolidine dithiocarbamic acid	95-122	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	297-302
8939960-5	1996	Inhibition of NF-kappaB activation with pyrrolidine dithiocarbamate eliminated the expression of iNOS in hepatocytes stimulated with LPS, TPP, or PDBu.	pyrrolidine dithiocarbamic acid	40-67	nitric oxide synthase 2	Rattus norvegicus	97-101
8943252-4	1996	The mechanism by which PKC-epsilon induced iNOS expression involved the activation of nuclear factor binding to kappaB sites (NF-kappaB) as deduced by the suppressive effect of pyrrolidine dithiocarbamate on nitric oxide synthesis, an inhibitor of NF-kappaB activation, and by the activation of kappaB sites in cells transfected with a vector containing a kappaB motif linked to a chloramphenicol acetyltransferase reporter gene.	pyrrolidine dithiocarbamic acid	177-204	protein kinase C, epsilon	Mus musculus	23-34
8943252-4	1996	The mechanism by which PKC-epsilon induced iNOS expression involved the activation of nuclear factor binding to kappaB sites (NF-kappaB) as deduced by the suppressive effect of pyrrolidine dithiocarbamate on nitric oxide synthesis, an inhibitor of NF-kappaB activation, and by the activation of kappaB sites in cells transfected with a vector containing a kappaB motif linked to a chloramphenicol acetyltransferase reporter gene.	pyrrolidine dithiocarbamic acid	177-204	nitric oxide synthase 2, inducible	Mus musculus	43-47
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	213-240	phospholipase A2 group IIA	Rattus norvegicus	27-32
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Rattus norvegicus	124-141
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Rattus norvegicus	143-151
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	242-246	phospholipase A2 group IIA	Rattus norvegicus	27-32
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Rattus norvegicus	124-141
8941724-4	1996	Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Rattus norvegicus	143-151
8903404-9	1996	The addition of the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate also inhibited NOS2 expression, suggesting a role for NF-kappaB in the cytokine induction of NOS2 in hepatocytes.	pyrrolidine dithiocarbamic acid	64-91	nitric oxide synthase 2	Rattus norvegicus	107-111
8896414-0	1996	Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	55-68
8896414-0	1996	Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.	pyrrolidine dithiocarbamic acid	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
8896414-0	1996	Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.	pyrrolidine dithiocarbamic acid	0-27	colony stimulating factor 2	Homo sapiens	89-137
8896414-0	1996	Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	218-228
8896414-3	1996	Thus, we have explored the effect of two inhibitors of the NF-kappa B activation, pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), on the production of these cytokines by EC.	pyrrolidine dithiocarbamic acid	82-109	nuclear factor kappa B subunit 1	Homo sapiens	59-69
8896414-3	1996	Thus, we have explored the effect of two inhibitors of the NF-kappa B activation, pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), on the production of these cytokines by EC.	pyrrolidine dithiocarbamic acid	111-115	nuclear factor kappa B subunit 1	Homo sapiens	59-69
8895350-7	1996	In intact cells, protection from NIC is associated with IL-1-induced expression of MnSOD activity, and reversible blockade of iNOS expression with pyrrolidine dithiocarbamate counteracts the NIC effect.	pyrrolidine dithiocarbamic acid	147-174	nitric oxide synthase 2	Homo sapiens	126-130
8903404-9	1996	The addition of the nuclear factor kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate also inhibited NOS2 expression, suggesting a role for NF-kappaB in the cytokine induction of NOS2 in hepatocytes.	pyrrolidine dithiocarbamic acid	64-91	nitric oxide synthase 2	Rattus norvegicus	185-189
8875956-6	1996	TBT induced a direct and concentration-related activation of NF-(kappa)B, which peaked at 2 h and was blocked by pyrrolidinedithiocarbamate, a potent NF-(kappa)B inhibitor, and rotenone, an inhibitor of the electron entry from complex I to ubiquinone.	pyrrolidine dithiocarbamic acid	113-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-72
8875956-6	1996	TBT induced a direct and concentration-related activation of NF-(kappa)B, which peaked at 2 h and was blocked by pyrrolidinedithiocarbamate, a potent NF-(kappa)B inhibitor, and rotenone, an inhibitor of the electron entry from complex I to ubiquinone.	pyrrolidine dithiocarbamic acid	113-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-161
8887559-4	1996	Treatment of WEH1 231 cells with N-tosyl-L-phenylalanine chloromethyl ketone (TPCK), a protease inhibitor which prevents degradation of the inhibitor of NF-kappaB (IkappaB)-alpha, or with low doses of pyrrolidinedithiocarbamate (PDTC) selectively inhibited NF-kappaB/Rel factor binding and induced apoptosis.	pyrrolidine dithiocarbamic acid	201-227	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
8824287-3	1996	In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.	pyrrolidine dithiocarbamic acid	73-100	mitogen-activated protein kinase 8	Homo sapiens	165-168
8824287-3	1996	In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.	pyrrolidine dithiocarbamic acid	73-100	mitogen-activated protein kinase 8	Homo sapiens	170-195
8824287-3	1996	In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.	pyrrolidine dithiocarbamic acid	102-106	mitogen-activated protein kinase 8	Homo sapiens	165-168
8824287-3	1996	In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.	pyrrolidine dithiocarbamic acid	102-106	mitogen-activated protein kinase 8	Homo sapiens	170-195
8871659-2	1996	In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC).	pyrrolidine dithiocarbamic acid	28-55	intercellular adhesion molecule 1	Homo sapiens	135-168
8871659-2	1996	In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC).	pyrrolidine dithiocarbamic acid	28-55	intercellular adhesion molecule 1	Homo sapiens	170-176
8871659-2	1996	In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC).	pyrrolidine dithiocarbamic acid	57-61	intercellular adhesion molecule 1	Homo sapiens	135-168
8871659-2	1996	In this study, we show that pyrrolidine dithiocarbamate (PDTC), a potent antioxidant agent, upregulated the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells (EC).	pyrrolidine dithiocarbamic acid	57-61	intercellular adhesion molecule 1	Homo sapiens	170-176
8887559-4	1996	Treatment of WEH1 231 cells with N-tosyl-L-phenylalanine chloromethyl ketone (TPCK), a protease inhibitor which prevents degradation of the inhibitor of NF-kappaB (IkappaB)-alpha, or with low doses of pyrrolidinedithiocarbamate (PDTC) selectively inhibited NF-kappaB/Rel factor binding and induced apoptosis.	pyrrolidine dithiocarbamic acid	229-233	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
8706912-4	1996	Pretreatment of cells with the antioxidant pyrrolidine dithiocarbamate completely suppressed the effects of neopterin on NF-kappa B activation, iNOS gene expression, and nitric oxide release.	pyrrolidine dithiocarbamic acid	43-70	nuclear factor kappa B subunit 1	Homo sapiens	121-131
8754764-7	1996	Pyrrolidine dithiocarbamate also reduced IL-1 beta-induced nitrite formation.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Rattus norvegicus	41-50
8760147-13	1996	IL-1 beta-mediated increases in steady-state iNOS mRNA were sensitive to pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation.	pyrrolidine dithiocarbamic acid	73-100	interleukin 1 beta	Rattus norvegicus	0-9
8760147-13	1996	IL-1 beta-mediated increases in steady-state iNOS mRNA were sensitive to pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation.	pyrrolidine dithiocarbamic acid	73-100	nitric oxide synthase 2	Rattus norvegicus	45-49
8766564-9	1996	TNF-alpha, but not cAMP-induced IL-10 gene expression was inhibited by pyrrolidine dithiocarbamate, suggesting the involvement of reactive oxygen species.	pyrrolidine dithiocarbamic acid	71-98	tumor necrosis factor	Homo sapiens	0-9
8679454-14	1996	Surprisingly, in addition to the activation of AP-1 DNA-binding via PDT, photodynamic treatment can decrease AP-1 DNA-binding of other strong inducers, such as the protein kinase C-mediated pathway of phorbol esters and the antioxidant pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	236-263	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-51
8679454-14	1996	Surprisingly, in addition to the activation of AP-1 DNA-binding via PDT, photodynamic treatment can decrease AP-1 DNA-binding of other strong inducers, such as the protein kinase C-mediated pathway of phorbol esters and the antioxidant pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	236-263	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
8679454-14	1996	Surprisingly, in addition to the activation of AP-1 DNA-binding via PDT, photodynamic treatment can decrease AP-1 DNA-binding of other strong inducers, such as the protein kinase C-mediated pathway of phorbol esters and the antioxidant pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	265-269	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-51
8679454-14	1996	Surprisingly, in addition to the activation of AP-1 DNA-binding via PDT, photodynamic treatment can decrease AP-1 DNA-binding of other strong inducers, such as the protein kinase C-mediated pathway of phorbol esters and the antioxidant pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	265-269	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Rattus norvegicus	212-221
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	0-27	mast cell protease 1-like 1	Rattus norvegicus	223-228
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	0-27	intercellular adhesion molecule 1	Rattus norvegicus	230-236
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	241-245
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	29-33	interleukin 1 beta	Rattus norvegicus	212-221
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	29-33	mast cell protease 1-like 1	Rattus norvegicus	223-228
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	29-33	intercellular adhesion molecule 1	Rattus norvegicus	230-236
8672550-6	1996	Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Rattus norvegicus	241-245
8706912-4	1996	Pretreatment of cells with the antioxidant pyrrolidine dithiocarbamate completely suppressed the effects of neopterin on NF-kappa B activation, iNOS gene expression, and nitric oxide release.	pyrrolidine dithiocarbamic acid	43-70	nitric oxide synthase 2	Homo sapiens	144-148
8662662-5	1996	The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation.	pyrrolidine dithiocarbamic acid	23-50	nitric oxide synthase 2	Rattus norvegicus	69-73
8662662-5	1996	The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation.	pyrrolidine dithiocarbamic acid	23-50	nitric oxide synthase 2	Rattus norvegicus	136-140
8662662-5	1996	The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation.	pyrrolidine dithiocarbamic acid	52-56	nitric oxide synthase 2	Rattus norvegicus	69-73
8662662-5	1996	The oxidant scavenger, pyrrolidine dithiocarbamate (PDTC), inhibited iNOS expression at the transcriptional level, since PDTC abolished iNOS mRNA accumulation.	pyrrolidine dithiocarbamic acid	52-56	nitric oxide synthase 2	Rattus norvegicus	136-140
8609398-4	1996	Apoptosis following IL-3 withdrawal and c-Myc-induced cell death was also effectively suppressed by the antioxidants pyrrolidine dithiocarbamate and glutathione peroxidase.	pyrrolidine dithiocarbamic acid	117-144	interleukin 3	Homo sapiens	20-24
8641463-3	1996	This increase was prevented by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), which also counteracted NO production by human islets exposed for 14 h to the cytokine combination.	pyrrolidine dithiocarbamic acid	56-83	nuclear factor kappa B subunit 1	Homo sapiens	35-44
8641463-3	1996	This increase was prevented by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), which also counteracted NO production by human islets exposed for 14 h to the cytokine combination.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	35-44
8609410-5	1996	Anti-VCAM-1 inhibited the increased T cell migration induced by BmA-stimulated supernatants by 97.7%, anti-VLA-4 by 74.7%, and blockade of NF-kappa B-dependent VCAM-1 transcription with 50 microM pyrrolidine dithiocarbamate resulted in 87.7% inhibition.	pyrrolidine dithiocarbamic acid	196-223	vascular cell adhesion molecule 1	Homo sapiens	5-11
8609410-5	1996	Anti-VCAM-1 inhibited the increased T cell migration induced by BmA-stimulated supernatants by 97.7%, anti-VLA-4 by 74.7%, and blockade of NF-kappa B-dependent VCAM-1 transcription with 50 microM pyrrolidine dithiocarbamate resulted in 87.7% inhibition.	pyrrolidine dithiocarbamic acid	196-223	nuclear factor kappa B subunit 1	Homo sapiens	139-149
8609410-5	1996	Anti-VCAM-1 inhibited the increased T cell migration induced by BmA-stimulated supernatants by 97.7%, anti-VLA-4 by 74.7%, and blockade of NF-kappa B-dependent VCAM-1 transcription with 50 microM pyrrolidine dithiocarbamate resulted in 87.7% inhibition.	pyrrolidine dithiocarbamic acid	196-223	vascular cell adhesion molecule 1	Homo sapiens	160-166
8609398-4	1996	Apoptosis following IL-3 withdrawal and c-Myc-induced cell death was also effectively suppressed by the antioxidants pyrrolidine dithiocarbamate and glutathione peroxidase.	pyrrolidine dithiocarbamic acid	117-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45
8660351-3	1996	Instead PMA-induced megakaryocytic differentiation of K562 cells was inhibited by the pretreatment of pyrrolidine dithiocarbamate, a specific nuclear factor kappaB (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	102-129	nuclear factor kappa B subunit 1	Homo sapiens	157-163
8660351-3	1996	Instead PMA-induced megakaryocytic differentiation of K562 cells was inhibited by the pretreatment of pyrrolidine dithiocarbamate, a specific nuclear factor kappaB (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	102-129	nuclear factor kappa B subunit 1	Homo sapiens	165-174
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	pyrrolidine dithiocarbamic acid	125-152	nitric oxide synthase 2	Homo sapiens	13-17
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	pyrrolidine dithiocarbamic acid	125-152	interferon gamma	Homo sapiens	66-82
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	pyrrolidine dithiocarbamic acid	125-152	interleukin 1 beta	Homo sapiens	87-96
7544377-6	1995	In addition, NiCl2-induced activation of NF-kappa B and adhesion molecule expression was inhibited by the antioxidant pyrrolidine dithiocarbamate, indicating the involvement of redox-dependent mechanisms.	pyrrolidine dithiocarbamic acid	118-145	nuclear factor kappa B subunit 1	Homo sapiens	41-51
8631978-4	1996	In addition, overexpression of Bcl-2 suppressed vascular smooth muscle cell death caused by PDTC and NAC.	pyrrolidine dithiocarbamic acid	92-96	BCL2, apoptosis regulator	Rattus norvegicus	31-36
8720483-5	1996	At a concentration of 25 mu M, which inhibited NO and biopterin synthesis but caused no cytotoxicity, pyrrolidine dithiocarbamate substantially reduced the LPS-induced increase in the abundance of NO synthase and GTP cyclohydrolase I mRNAs.	pyrrolidine dithiocarbamic acid	102-129	GTP cyclohydrolase 1	Rattus norvegicus	213-233
8720483-6	1996	These results suggest that pyrrolidine dithiocarbamate inhibits LPS-induced NO and biopterin synthesis by inhibiting the expression of NO synthase and GTP cyclohydrolase I genes.	pyrrolidine dithiocarbamic acid	27-54	GTP cyclohydrolase 1	Rattus norvegicus	151-171
8769830-3	1996	In rat mesangial cells treated with an inhibitor of NF-kappa B, pyrrolidine dithiocarbamate, induction of MMP-9 by IL-1 beta was suppressed at both mRNA and protein levels.	pyrrolidine dithiocarbamic acid	64-91	matrix metallopeptidase 9	Rattus norvegicus	106-111
8769830-3	1996	In rat mesangial cells treated with an inhibitor of NF-kappa B, pyrrolidine dithiocarbamate, induction of MMP-9 by IL-1 beta was suppressed at both mRNA and protein levels.	pyrrolidine dithiocarbamic acid	64-91	interleukin 1 beta	Rattus norvegicus	115-124
7500055-10	1995	Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	226-253	interleukin 1 beta	Homo sapiens	37-84
7588208-4	1995	Inhibitors of NFkappaB, diethyldithiocarbamate, pyrrolidine dithiocarbamate, and N-acetyl cysteine prevent IL-1-induced iNOS expression at the level of messenger RNA, protein, and nitrite generation.	pyrrolidine dithiocarbamic acid	48-75	nitric oxide synthase 2	Rattus norvegicus	120-124
7588208-8	1995	IL-1-induced translocation of NF kappa B was blocked by 100 microns 100 microM diethyldithiocarbamate or 100 microM pyrrolidine dithiocarbamate, further establishing a critical role for NF kappa B in the induction of iNOS by IL-1 in rat pancreatic beta-cells.	pyrrolidine dithiocarbamic acid	116-143	nitric oxide synthase 2	Rattus norvegicus	217-221
7545393-0	1995	Inhibition of NF-kappa B by pyrrolidine dithiocarbamate blocks endothelial cell activation.	pyrrolidine dithiocarbamic acid	28-55	nuclear factor kappa B subunit 1	Homo sapiens	14-24
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	tumor necrosis factor	Homo sapiens	62-71
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	selectin E	Homo sapiens	94-104
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	vascular cell adhesion molecule 1	Homo sapiens	106-112
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	intercellular adhesion molecule 1	Homo sapiens	114-120
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	serpin family E member 1	Homo sapiens	122-127
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	coagulation factor III, tissue factor	Homo sapiens	129-142
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	NFKB inhibitor alpha	Homo sapiens	153-168
8770966-6	1996	In contrast, the ROS scavengers dimethylthiourea (DMTU), dimethylpyrroline N-oxide, or pyrrolidine dithiocarbamate reduced basal ET-1 release, while DMTU lowered ET-1 mRNA levels.	pyrrolidine dithiocarbamic acid	87-114	endothelin 1	Homo sapiens	129-133
8569701-4	1996	Pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kappa B (NF-kappa B) activation, also significantly decreased cytomix-induced NOS II mRNA levels.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	45-67
8569701-4	1996	Pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kappa B (NF-kappa B) activation, also significantly decreased cytomix-induced NOS II mRNA levels.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	69-79
8569701-4	1996	Pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kappa B (NF-kappa B) activation, also significantly decreased cytomix-induced NOS II mRNA levels.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2, inducible	Mus musculus	138-144
7592968-9	1995	Both reactive oxygen intermediates production and NF-kappa B activation were inhibited by the antioxidant pyrrolidine dithiocarbamate and 8-(diethylamino)octyl-3,4,5-trimethyoxybenzoate, a Ca2+ chelator.	pyrrolidine dithiocarbamic acid	106-133	nuclear factor kappa B subunit 1	Homo sapiens	50-60
7592595-11	1995	In contrast to NAC and glutathione, diethyl dithiocarbamate and pyrrolidine dithiocarbamate, which inactivate reactive oxygen intermediates and chelate Zn(II), synergistically augment the induction of MT-1 mRNA levels and reporter gene activity in response to heme-hemopexin via the antioxidant response element by both metal-responsive element-dependent and -independent mechanisms.	pyrrolidine dithiocarbamic acid	64-91	metallothionein 1	Mus musculus	201-205
7592595-11	1995	In contrast to NAC and glutathione, diethyl dithiocarbamate and pyrrolidine dithiocarbamate, which inactivate reactive oxygen intermediates and chelate Zn(II), synergistically augment the induction of MT-1 mRNA levels and reporter gene activity in response to heme-hemopexin via the antioxidant response element by both metal-responsive element-dependent and -independent mechanisms.	pyrrolidine dithiocarbamic acid	64-91	hemopexin	Mus musculus	265-274
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	nuclear factor kappa B subunit 1	Homo sapiens	99-121
7857277-3	1995	Therefore, we have assessed the effect of pyrrolidine dithiocarbamate (PDTC), an oxygen-radical scavenger and metal chelator that is a selective and potent inhibitor of NF-kappa B activation, on osteoclastic bone resorption in the bone slice assay.	pyrrolidine dithiocarbamic acid	42-69	nuclear factor kappa B subunit 1	Homo sapiens	169-179
7857277-3	1995	Therefore, we have assessed the effect of pyrrolidine dithiocarbamate (PDTC), an oxygen-radical scavenger and metal chelator that is a selective and potent inhibitor of NF-kappa B activation, on osteoclastic bone resorption in the bone slice assay.	pyrrolidine dithiocarbamic acid	71-75	nuclear factor kappa B subunit 1	Homo sapiens	169-179
7642556-2	1995	The H2O2-induced increase in ICAM-1 mRNA was inhibited by actinomycin D, by the antioxidant N-acetylcysteine, and by 3-amino-benzamide (which blocks oxidant-induced AP-1 activity), but not by pyrrolidine dithiocarbamate (which blocks oxidant-induced NF-kappa B activity).	pyrrolidine dithiocarbamic acid	192-219	intercellular adhesion molecule 1	Homo sapiens	29-35
7605983-0	1995	Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists.	pyrrolidine dithiocarbamic acid	0-27	coagulation factor III, tissue factor	Homo sapiens	38-51
7605983-0	1995	Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists.	pyrrolidine dithiocarbamic acid	0-27	coagulation factor III, tissue factor	Homo sapiens	53-55
7605983-0	1995	Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists.	pyrrolidine dithiocarbamic acid	0-27	coagulation factor III, tissue factor	Homo sapiens	137-139
7605983-3	1995	We have examined the effect of pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of the NF kappa B pathway on the expression of the endogenous TF gene in human umbilical vein endothelial cells (HUVEC).	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	95-105
7605983-3	1995	We have examined the effect of pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of the NF kappa B pathway on the expression of the endogenous TF gene in human umbilical vein endothelial cells (HUVEC).	pyrrolidine dithiocarbamic acid	31-58	coagulation factor III, tissue factor	Homo sapiens	150-152
7605983-3	1995	We have examined the effect of pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of the NF kappa B pathway on the expression of the endogenous TF gene in human umbilical vein endothelial cells (HUVEC).	pyrrolidine dithiocarbamic acid	60-64	coagulation factor III, tissue factor	Homo sapiens	150-152
7539253-6	1995	The inhibitor of NF-kappa B activation, pyrrolidine dithiocarbamate, inhibited the induction of iNOS but not AII.	pyrrolidine dithiocarbamic acid	40-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	17-27
7539253-6	1995	The inhibitor of NF-kappa B activation, pyrrolidine dithiocarbamate, inhibited the induction of iNOS but not AII.	pyrrolidine dithiocarbamic acid	40-67	nitric oxide synthase 2, inducible	Mus musculus	96-100
7539253-6	1995	The inhibitor of NF-kappa B activation, pyrrolidine dithiocarbamate, inhibited the induction of iNOS but not AII.	pyrrolidine dithiocarbamic acid	40-67	arginase type II	Mus musculus	109-112
7750575-0	1995	Pyrrolidine dithiocarbamate differentially affects cytokine- and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells.	pyrrolidine dithiocarbamic acid	0-27	phospholipase A2 group IB	Rattus norvegicus	101-117
7721885-6	1995	Furthermore, compounds such as tosylphenylalanyl chloromethyl ketone and pyrrolidinedithiocarbamate that are known to selectively inhibit NF kappa B activation block cytokine gene transcription in LPS-stimulated monocytes.	pyrrolidine dithiocarbamic acid	73-99	nuclear factor kappa B subunit 1	Homo sapiens	138-148
7713868-8	1995	Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	46-56
7713868-8	1995	Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.	pyrrolidine dithiocarbamic acid	0-27	PCNA clamp associated factor	Homo sapiens	86-89
7713868-8	1995	Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.	pyrrolidine dithiocarbamic acid	0-27	heparin binding EGF like growth factor	Homo sapiens	154-160
7532665-0	1995	Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts.	pyrrolidine dithiocarbamic acid	0-27	intercellular adhesion molecule 1	Homo sapiens	37-70
7532665-3	1995	In this report, we investigated the effects of dexamethasone, cyclosporin A, FK506, and pyrrolidine dithiocarbamate (PDTC) on the induction of the ICAM-1 gene by cytokines in fibroblasts.	pyrrolidine dithiocarbamic acid	88-115	intercellular adhesion molecule 1	Homo sapiens	147-153
7532665-3	1995	In this report, we investigated the effects of dexamethasone, cyclosporin A, FK506, and pyrrolidine dithiocarbamate (PDTC) on the induction of the ICAM-1 gene by cytokines in fibroblasts.	pyrrolidine dithiocarbamic acid	117-121	intercellular adhesion molecule 1	Homo sapiens	147-153
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	nuclear factor kappa B subunit 1	Homo sapiens	123-133
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	nitric oxide synthase 2	Homo sapiens	179-183
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	superoxide dismutase 2	Homo sapiens	189-219
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	superoxide dismutase 2	Homo sapiens	221-226
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	41-68	interleukin 1 beta	Homo sapiens	237-246
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	nuclear factor kappa B subunit 1	Homo sapiens	99-121
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	nuclear factor kappa B subunit 1	Homo sapiens	123-133
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	nitric oxide synthase 2	Homo sapiens	179-183
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	superoxide dismutase 2	Homo sapiens	189-219
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	superoxide dismutase 2	Homo sapiens	221-226
7539260-1	1995	We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells.	pyrrolidine dithiocarbamic acid	70-74	interleukin 1 beta	Homo sapiens	237-246
8867670-5	1995	Both functions were dependent on PGHS1 peroxidase activity and could be suppressed by the potent antioxidant pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	109-136	prostaglandin-endoperoxide synthase 1	Homo sapiens	33-38
7767900-5	1995	Taxol-induced nuclear translocation of NF-kappa B was inhibited by pyrrolidine dithiocarbamate, an antioxidant, but not by cycloheximide, a protein synthesis inhibitor.	pyrrolidine dithiocarbamic acid	67-94	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-49
7986199-0	1994	Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	51-73
7798616-3	1994	Expression of ICAM-1 was induced on keratinocytes by treatment with 300 microM H2O2 for 1 h. The antioxidant N-acetyl-L-cysteine strongly inhibited H2O2-induced ICAM-1 expression, whereas the antioxidants pyrrolidine dithiocarbamate and alpha-tocopherol were less inhibitory.	pyrrolidine dithiocarbamic acid	205-232	intercellular adhesion molecule 1	Homo sapiens	14-20
7798616-4	1994	N-acetyl-L-cysteine also suppressed keratinocyte surface expression of ICAM-1 induced by the cytokines interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha), whereas pyrrolidine dithiocarbamate and alpha-tocopherol suppressed IFN-gamma-induced surface expression but not TNF-alpha-induced expression.	pyrrolidine dithiocarbamic acid	184-211	intercellular adhesion molecule 1	Homo sapiens	71-77
7982975-2	1994	Fc gamma 2a receptor-mediated activation of NF-kappa B was blocked by the presence of pyrrolidinedithiocarbamate, neutralizing anti-tumor necrosis factor (TNF)-alpha antibodies, various protein kinase inhibitors (H-89, genistein, or heparin) or intracellular calcium chelator (1,2-bis(O-aminophenoxy)-ethane-N,N,N",N"-tetraacetic acid tetra-(acetoxymethyl)-ester, BAPTA/AM) during stimulation.	pyrrolidine dithiocarbamic acid	86-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-54
7986199-0	1994	Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	75-85
7986199-1	1994	We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.	pyrrolidine dithiocarbamic acid	26-53	nuclear factor kappa B subunit 1	Homo sapiens	102-124
7986199-1	1994	We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.	pyrrolidine dithiocarbamic acid	26-53	nuclear factor kappa B subunit 1	Homo sapiens	126-136
7986199-1	1994	We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.	pyrrolidine dithiocarbamic acid	55-59	nuclear factor kappa B subunit 1	Homo sapiens	102-124
7986199-1	1994	We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.	pyrrolidine dithiocarbamic acid	55-59	nuclear factor kappa B subunit 1	Homo sapiens	126-136
7957109-8	1994	Pyrrolidinedithiocarbamate, an antioxidant inhibitor of NF-kappa B activation which did not interfere with proteasome activities, prevented de novo phosphorylation of I kappa B-alpha as well as its subsequent degradation.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	56-66
7533726-2	1994	The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta.	pyrrolidine dithiocarbamic acid	16-43	interleukin 1 beta	Rattus norvegicus	154-172
7957109-8	1994	Pyrrolidinedithiocarbamate, an antioxidant inhibitor of NF-kappa B activation which did not interfere with proteasome activities, prevented de novo phosphorylation of I kappa B-alpha as well as its subsequent degradation.	pyrrolidine dithiocarbamic acid	0-26	NFKB inhibitor alpha	Homo sapiens	167-182
7998962-6	1994	By contrast, treatment of cells with pyrrolidine dithiocarbamate (PDTC) will only block LPS-induced NF-kappa B, but not the constitutive binding protein.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	100-110
7533726-2	1994	The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta.	pyrrolidine dithiocarbamic acid	16-43	interleukin 1 beta	Rattus norvegicus	202-220
7533726-5	1994	These observations suggest that pyrrolidine dithiocarbamate prevents the interleukin-1 beta-mediated expression of the inducible nitric oxide synthase without affecting the activity of the constitutive enzyme in the rat aorta.	pyrrolidine dithiocarbamic acid	32-59	interleukin 1 beta	Rattus norvegicus	73-91
8491191-2	1993	DNA binding and transactivation by AP-1 were induced in HeLa cells upon treatment with the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC), and upon transient expression of the antioxidative enzyme thioredoxin.	pyrrolidine dithiocarbamic acid	104-131	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
7957773-3	1994	The intracellular oxidation state was increased 60 min after the addition of TNF alpha, and this increase was abolished by a radical scavenger, N-acetylcysteine (NAC), which is also a precursor of glutathione, and by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	217-244	tumor necrosis factor	Homo sapiens	77-86
7957773-3	1994	The intracellular oxidation state was increased 60 min after the addition of TNF alpha, and this increase was abolished by a radical scavenger, N-acetylcysteine (NAC), which is also a precursor of glutathione, and by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	246-250	tumor necrosis factor	Homo sapiens	77-86
8046241-5	1994	In the absence of adenosine and homocysteine TNF-alpha-mediated cytotoxicity was inhibited by antioxidants such as butylated hydroxyanisole and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	144-171	tumor necrosis factor	Mus musculus	45-54
7513157-0	1994	Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.	pyrrolidine dithiocarbamic acid	0-27	interleukin 1 beta	Rattus norvegicus	51-69
7513157-3	1994	We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression.	pyrrolidine dithiocarbamic acid	13-40	interleukin 1 beta	Rattus norvegicus	133-142
7513157-3	1994	We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression.	pyrrolidine dithiocarbamic acid	42-46	interleukin 1 beta	Rattus norvegicus	133-142
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-26
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	histocompatibility-2, MHC	Mus musculus	112-115
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	tumor necrosis factor	Mus musculus	127-130
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-167
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	tumor necrosis factor	Mus musculus	184-187
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	39-65	histocompatibility-2, MHC	Mus musculus	196-199
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-26
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	histocompatibility-2, MHC	Mus musculus	112-115
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	tumor necrosis factor	Mus musculus	127-130
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-167
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	tumor necrosis factor	Mus musculus	184-187
8283141-7	1994	An inhibitor of NF-kappa B activation, pyrrolidinedithiocarbamate (PDTC), dramatically reduced the induction of H-2 antigen by TNF, supporting the view that NF-kappa B is required for TNF-induced H-2 antigen expression.	pyrrolidine dithiocarbamic acid	67-71	histocompatibility-2, MHC	Mus musculus	196-199
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	213-240	interleukin 1 beta	Homo sapiens	92-101
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	213-240	vascular cell adhesion molecule 1	Homo sapiens	113-119
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Homo sapiens	72-90
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	242-246	interleukin 1 beta	Homo sapiens	92-101
7691889-3	1993	In cultured human umbilical vein endothelial (HUVE) cells, the cytokine interleukin 1 beta (IL-1 beta) activated VCAM-1 gene expression through a mechanism that was repressed approximately 90% by the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC).	pyrrolidine dithiocarbamic acid	242-246	vascular cell adhesion molecule 1	Homo sapiens	113-119
7522548-2	1994	The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	87-109
7522548-2	1994	The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	16-43	nuclear factor kappa B subunit 1	Homo sapiens	111-121
7522548-2	1994	The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	45-49	nuclear factor kappa B subunit 1	Homo sapiens	87-109
7522548-2	1994	The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).	pyrrolidine dithiocarbamic acid	45-49	nuclear factor kappa B subunit 1	Homo sapiens	111-121
8138998-7	1994	The response to tumor necrosis factor alpha seems to be mediated by an NF-kappa B-related mechanism, since the induction can be completely abrogated by pretreating the cells with an antioxidant such as pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	202-229	tumor necrosis factor	Mus musculus	16-43
8127864-5	1994	A similar increase of AP-1 activity was also observed with other, structurally unrelated antioxidants such as pyrrolidine dithiocarbamate and butylated hydroxyanisole, indicating that the thioredoxin-induced increase of AP-1 activation was indeed based on an antioxidant effect.	pyrrolidine dithiocarbamic acid	110-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-26
8127864-5	1994	A similar increase of AP-1 activity was also observed with other, structurally unrelated antioxidants such as pyrrolidine dithiocarbamate and butylated hydroxyanisole, indicating that the thioredoxin-induced increase of AP-1 activation was indeed based on an antioxidant effect.	pyrrolidine dithiocarbamic acid	110-137	thioredoxin	Homo sapiens	188-199
8127864-5	1994	A similar increase of AP-1 activity was also observed with other, structurally unrelated antioxidants such as pyrrolidine dithiocarbamate and butylated hydroxyanisole, indicating that the thioredoxin-induced increase of AP-1 activation was indeed based on an antioxidant effect.	pyrrolidine dithiocarbamic acid	110-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	220-224
7508926-6	1994	Pyrrolidine dithiocarbamate, which acts as a specific inhibitor of NF-kappa B, blocked both the activation of the NF-kappa Bd-binding proteins and the production of NO in LPS-treated macrophages.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-77
8258705-0	1993	Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	37-47
8258705-0	1993	Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Homo sapiens	65-68
8491191-2	1993	DNA binding and transactivation by AP-1 were induced in HeLa cells upon treatment with the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC), and upon transient expression of the antioxidative enzyme thioredoxin.	pyrrolidine dithiocarbamic acid	133-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
8098618-11	1993	Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	139-149
8098618-11	1993	Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.	pyrrolidine dithiocarbamic acid	31-58	interleukin 2	Homo sapiens	183-187
8098618-11	1993	Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.	pyrrolidine dithiocarbamic acid	31-58	interleukin 2 receptor subunit alpha	Homo sapiens	199-210
7682068-2	1993	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation, was added to cultured macrophages stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN gamma).	pyrrolidine dithiocarbamic acid	0-27	interferon gamma	Rattus norvegicus	154-170
7682068-2	1993	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation, was added to cultured macrophages stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN gamma).	pyrrolidine dithiocarbamic acid	0-27	interferon gamma	Rattus norvegicus	172-181
7682068-2	1993	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation, was added to cultured macrophages stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN gamma).	pyrrolidine dithiocarbamic acid	29-33	interferon gamma	Rattus norvegicus	154-170
7682068-2	1993	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation, was added to cultured macrophages stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN gamma).	pyrrolidine dithiocarbamic acid	29-33	interferon gamma	Rattus norvegicus	172-181
33814923-11	2021	PDTC, an inhibitor of IkappaBalpha phosphorylation, suppressed the decrease in the PGC-1alpha protein level induced by rhTWEAK treatment.	pyrrolidine dithiocarbamic acid	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	22-34
33591571-6	2021	In SKI SMCs, inhibition of NF-kappaB by pyrrolidinedithiocarbamic acid (PDTC) or overexpression of PPARgamma2 reversed the protein expression of SMC phenotypic modulation markers, and inhibited cell proliferation, migration, and macrophage adhesion to SMCs.	pyrrolidine dithiocarbamic acid	40-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
33591571-6	2021	In SKI SMCs, inhibition of NF-kappaB by pyrrolidinedithiocarbamic acid (PDTC) or overexpression of PPARgamma2 reversed the protein expression of SMC phenotypic modulation markers, and inhibited cell proliferation, migration, and macrophage adhesion to SMCs.	pyrrolidine dithiocarbamic acid	72-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
1404592-3	1992	In this study, we used the antioxidant pyrrolidine dithiocarbamate (PDTC) to investigate whether the activation of NF-kappa B by the viral transactivator Tax from human T-cell leukemia virus type I also depends on the production of reactive oxygen intermediates.	pyrrolidine dithiocarbamic acid	39-66	nuclear factor kappa B subunit 1	Homo sapiens	115-125
1404592-3	1992	In this study, we used the antioxidant pyrrolidine dithiocarbamate (PDTC) to investigate whether the activation of NF-kappa B by the viral transactivator Tax from human T-cell leukemia virus type I also depends on the production of reactive oxygen intermediates.	pyrrolidine dithiocarbamic acid	68-72	nuclear factor kappa B subunit 1	Homo sapiens	115-125
33814923-11	2021	PDTC, an inhibitor of IkappaBalpha phosphorylation, suppressed the decrease in the PGC-1alpha protein level induced by rhTWEAK treatment.	pyrrolidine dithiocarbamic acid	0-4	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	83-93
33776453-7	2021	The expression of these proteins was also evaluated after treatment with PDTC, an inhibitor of the NF-kappaB pathway inhibitor.	pyrrolidine dithiocarbamic acid	73-77	nuclear factor kappa B subunit 1	Homo sapiens	99-108
33776453-11	2021	Anecdotally, these effects were reversed by the application of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	63-90	nuclear factor kappa B subunit 1	Homo sapiens	115-124
33776453-11	2021	Anecdotally, these effects were reversed by the application of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	92-96	nuclear factor kappa B subunit 1	Homo sapiens	115-124
34463587-3	2021	IL-1beta-induced chondrocyte was treated with A20 lentivirus activation particle, pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) with/without A20 siRNA.	pyrrolidine dithiocarbamic acid	82-109	interleukin 1 alpha	Homo sapiens	0-8
34340576-12	2021	Taken together, we conclude that PDTC may reduce MTX-induced testicular damage via NFkB, Nrf2 and PK2 signaling pathways.	pyrrolidine dithiocarbamic acid	33-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
34340576-12	2021	Taken together, we conclude that PDTC may reduce MTX-induced testicular damage via NFkB, Nrf2 and PK2 signaling pathways.	pyrrolidine dithiocarbamic acid	33-37	prokineticin 2	Rattus norvegicus	98-101
34463587-3	2021	IL-1beta-induced chondrocyte was treated with A20 lentivirus activation particle, pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) with/without A20 siRNA.	pyrrolidine dithiocarbamic acid	111-115	interleukin 1 alpha	Homo sapiens	0-8
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	interleukin 1 alpha	Homo sapiens	28-36
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	collagen type I alpha 1 chain	Homo sapiens	88-94
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	collagen type II alpha 1 chain	Homo sapiens	96-102
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	collagen type X alpha 1 chain	Homo sapiens	104-111
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	aggrecan	Homo sapiens	116-120
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	matrix metallopeptidase 1	Homo sapiens	152-156
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	matrix metallopeptidase 13	Homo sapiens	158-163
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-169
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	inositol-3-phosphate synthase 1	Homo sapiens	171-175
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	interleukin 6	Homo sapiens	177-181
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	tumor necrosis factor	Homo sapiens	183-192
34463587-11	2021	Furthermore, PDTC decreased IL-1beta-induced chondrocyte apoptosis with the upregulated COL1A1, COL2A1, COL10A1 and ACAN, as well as the down-regulated MMP1, MMP13, COX2, iNOS, IL-6, TNF-alpha, NO and PGE2, which was reversed by A20 siRNA.	pyrrolidine dithiocarbamic acid	13-17	TNF alpha induced protein 3	Homo sapiens	229-232
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	14-41	NLR family, pyrin domain containing 3	Mus musculus	204-209
34310252-0	2021	The protective effect of NF-kappaB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis.	pyrrolidine dithiocarbamic acid	63-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	324-333
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	43-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	43-47	NLR family, pyrin domain containing 3	Mus musculus	204-209
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	43-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	324-333
34787893-8	2021	Overexpression of S100A10 had an effect similar to TNF-alpha,which was significantly counteracted by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, or verapamil, a calcium-channel blocker.	pyrrolidine dithiocarbamic acid	101-128	S100 calcium binding protein A10	Homo sapiens	18-25
34787893-8	2021	Overexpression of S100A10 had an effect similar to TNF-alpha,which was significantly counteracted by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, or verapamil, a calcium-channel blocker.	pyrrolidine dithiocarbamic acid	101-128	tumor necrosis factor	Homo sapiens	51-60
34787893-8	2021	Overexpression of S100A10 had an effect similar to TNF-alpha,which was significantly counteracted by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, or verapamil, a calcium-channel blocker.	pyrrolidine dithiocarbamic acid	101-128	nuclear factor kappa B subunit 1	Homo sapiens	133-142
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	89-120	inhibitor of DNA binding 2	Homo sapiens	15-19
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	89-120	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	89-120	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	122-126	inhibitor of DNA binding 2	Homo sapiens	15-19
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	122-126	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
34804049-8	2021	Interestingly, hID2 showed a synergistic role in inhibition of NF-kappaB activation with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-kappaB activation.	pyrrolidine dithiocarbamic acid	122-126	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
34172831-7	2021	Blocking the NF-kappaB pathway with ammonium pyrrolidinedithiocarbamate (PDTC) successfully inhibited IL-17A-induced expression of senescence-associated proteins.	pyrrolidine dithiocarbamic acid	36-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-22
34172831-7	2021	Blocking the NF-kappaB pathway with ammonium pyrrolidinedithiocarbamate (PDTC) successfully inhibited IL-17A-induced expression of senescence-associated proteins.	pyrrolidine dithiocarbamic acid	36-71	interleukin 17A	Mus musculus	102-108
34172831-7	2021	Blocking the NF-kappaB pathway with ammonium pyrrolidinedithiocarbamate (PDTC) successfully inhibited IL-17A-induced expression of senescence-associated proteins.	pyrrolidine dithiocarbamic acid	73-77	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-22
34172831-7	2021	Blocking the NF-kappaB pathway with ammonium pyrrolidinedithiocarbamate (PDTC) successfully inhibited IL-17A-induced expression of senescence-associated proteins.	pyrrolidine dithiocarbamic acid	73-77	interleukin 17A	Mus musculus	102-108
34469786-10	2021	Rescue experiments suggested that FTO overexpression-mediated osteoclast differentiation was suppressed after intervention with a NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	150-177	fat mass and obesity associated	Mus musculus	34-37
34469786-10	2021	Rescue experiments suggested that FTO overexpression-mediated osteoclast differentiation was suppressed after intervention with a NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
34481006-7	2021	The results demonstrated that administration of PDTC NPs + TA NPs minimized oxidative stress in lens as evidenced by reduced levels of protein carbonyls and malondialdehyde, and, ameliorated DR complications in retina as evidenced by reduced expression of hypoxia inducible factor-1alpha along with a reduction in number of neovascular tufts and acellular capillaries.	pyrrolidine dithiocarbamic acid	48-52	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	256-287
34803490-9	2021	Meanwhile, In vitro assays showed SOCS2 overexpression in macrophages suppressed inflammation and apoptosis via inhibiting NF-kappaB signaling pathway, while SOCS2 knock-down in macrophages caused an increased activation of NF-kappaB, which could be blocked by ammonium 1-pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	261-298	suppressor of cytokine signaling 2	Homo sapiens	34-39
34803490-9	2021	Meanwhile, In vitro assays showed SOCS2 overexpression in macrophages suppressed inflammation and apoptosis via inhibiting NF-kappaB signaling pathway, while SOCS2 knock-down in macrophages caused an increased activation of NF-kappaB, which could be blocked by ammonium 1-pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	261-298	suppressor of cytokine signaling 2	Homo sapiens	158-163
34803490-9	2021	Meanwhile, In vitro assays showed SOCS2 overexpression in macrophages suppressed inflammation and apoptosis via inhibiting NF-kappaB signaling pathway, while SOCS2 knock-down in macrophages caused an increased activation of NF-kappaB, which could be blocked by ammonium 1-pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	261-298	nuclear factor kappa B subunit 1	Homo sapiens	224-233
34446210-6	2021	Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4).	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	153-157
34446210-6	2021	Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4).	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	220-247
34446210-6	2021	Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4).	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Rattus norvegicus	153-157
34446210-6	2021	Pyrrolidine dithiocarbamate (PDTC), NF-kappaB inhibitor, did not alter CYP2E1 but mitigated free radical generation, SOD activity, LPO, nitrite content, iNOS activity/expression and levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukine-1beta and interleukine-4).	pyrrolidine dithiocarbamic acid	29-33	tumor necrosis factor	Rattus norvegicus	220-247
34310252-1	2021	OBJECTIVE: To understand the protective effect of NF-kappaB signaling pathway inhibitor pyrrolidinedithiocarbamate (PDTC) on mice with chronic atrophic gastritis (CAG).	pyrrolidine dithiocarbamic acid	88-114	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-59
34310252-1	2021	OBJECTIVE: To understand the protective effect of NF-kappaB signaling pathway inhibitor pyrrolidinedithiocarbamate (PDTC) on mice with chronic atrophic gastritis (CAG).	pyrrolidine dithiocarbamic acid	116-120	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-59
34310252-4	2021	RESULTS: The nuclear content of NF-kappaB p65 in the gastric mucosa of the CAG mice was increased accompanying by the structural disorder of the gastric mucosal epithelium, inflammatory cell infiltration, intestinal metaplasia, and increased MUC2 expression, but the symptoms were alleviated after PDTC treatment.	pyrrolidine dithiocarbamic acid	298-302	mucin 2	Mus musculus	242-246
34310252-5	2021	In addition, the expressions of TNF-alpha, IL-1beta, IL-6 and COX2 in the gastric mucosa and serum of CAG mice were higher than those control mice, which were reduced in CAG mice treated with either 100 or 200 mg/kg PDTC.	pyrrolidine dithiocarbamic acid	216-220	tumor necrosis factor	Mus musculus	32-41
34310252-5	2021	In addition, the expressions of TNF-alpha, IL-1beta, IL-6 and COX2 in the gastric mucosa and serum of CAG mice were higher than those control mice, which were reduced in CAG mice treated with either 100 or 200 mg/kg PDTC.	pyrrolidine dithiocarbamic acid	216-220	interleukin 1 alpha	Mus musculus	43-51
34310252-5	2021	In addition, the expressions of TNF-alpha, IL-1beta, IL-6 and COX2 in the gastric mucosa and serum of CAG mice were higher than those control mice, which were reduced in CAG mice treated with either 100 or 200 mg/kg PDTC.	pyrrolidine dithiocarbamic acid	216-220	interleukin 6	Mus musculus	53-57
34310252-5	2021	In addition, the expressions of TNF-alpha, IL-1beta, IL-6 and COX2 in the gastric mucosa and serum of CAG mice were higher than those control mice, which were reduced in CAG mice treated with either 100 or 200 mg/kg PDTC.	pyrrolidine dithiocarbamic acid	216-220	cytochrome c oxidase II, mitochondrial	Mus musculus	62-66
34310252-6	2021	Furthermore, 100 mg/kg and 200 mg/kg PDTC treatments reduced the serum PGE2 in CAG mice with the decreased PCNA and Ki-67 expression in gastric mucosa.	pyrrolidine dithiocarbamic acid	37-41	proliferating cell nuclear antigen	Mus musculus	107-111
34310252-6	2021	Furthermore, 100 mg/kg and 200 mg/kg PDTC treatments reduced the serum PGE2 in CAG mice with the decreased PCNA and Ki-67 expression in gastric mucosa.	pyrrolidine dithiocarbamic acid	37-41	antigen identified by monoclonal antibody Ki 67	Mus musculus	116-121
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	80-107	nuclear factor kappa B subunit 1	Homo sapiens	22-31
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	80-107	Wnt family member 3A	Homo sapiens	136-141
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	80-107	catenin beta 1	Homo sapiens	142-154
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	109-113	nuclear factor kappa B subunit 1	Homo sapiens	22-31
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	109-113	Wnt family member 3A	Homo sapiens	136-141
34153668-8	2021	Importantly, when the NF-kappaB signaling pathway was blocked by its inhibitor, pyrrolidine dithiocarbamate (PDTC), the activity of the Wnt3a/beta-catenin signaling pathway was abolished, and consequently led to the attenuation of the inflammation response in LPS-induced human periodontal ligament cells (hPDLCs).	pyrrolidine dithiocarbamic acid	109-113	catenin beta 1	Homo sapiens	142-154
34437439-9	2021	Furthermore, we found that ammonium pyrrolidinedithiocarbamate (PDTC) restored AAI-induced MT-I/II reduction in HK2 cells.	pyrrolidine dithiocarbamic acid	27-62	metallothionein 3	Mus musculus	91-98
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	14-41	nuclear factor kappa B subunit 1	Homo sapiens	53-62
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	14-41	angiotensin converting enzyme 2	Homo sapiens	96-100
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	43-47	nuclear factor kappa B subunit 1	Homo sapiens	53-62
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	43-47	angiotensin converting enzyme 2	Homo sapiens	96-100
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	pyrrolidine dithiocarbamic acid	49-53	angiotensin converting enzyme 2	Homo sapiens	133-137
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	pyrrolidine dithiocarbamic acid	120-124	angiotensin converting enzyme 2	Homo sapiens	133-137
34437439-9	2021	Furthermore, we found that ammonium pyrrolidinedithiocarbamate (PDTC) restored AAI-induced MT-I/II reduction in HK2 cells.	pyrrolidine dithiocarbamic acid	64-68	metallothionein 3	Mus musculus	91-98
34194560-13	2021	These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs.	pyrrolidine dithiocarbamic acid	132-159	microRNA 155	Homo sapiens	32-39
34646528-11	2021	Furthermore, shikonin treatment significantly inhibited the expression of p-P65 and nuclear translocation of P65, and nuclear factor-kappa B (NF-kappaB) pathway inhibitor Pyrrolidinedithiocarbamate ammonium (PDTC) significantly enhanced the anti-inflammatory and antiapoptotic effects of shikonin in LPS-induced NP cells.	pyrrolidine dithiocarbamic acid	171-206	nuclear factor kappa B subunit 1	Homo sapiens	118-140
34646528-11	2021	Furthermore, shikonin treatment significantly inhibited the expression of p-P65 and nuclear translocation of P65, and nuclear factor-kappa B (NF-kappaB) pathway inhibitor Pyrrolidinedithiocarbamate ammonium (PDTC) significantly enhanced the anti-inflammatory and antiapoptotic effects of shikonin in LPS-induced NP cells.	pyrrolidine dithiocarbamic acid	171-206	nuclear factor kappa B subunit 1	Homo sapiens	142-151
34194560-13	2021	These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs.	pyrrolidine dithiocarbamic acid	132-159	nuclear factor kappa B subunit 1	Homo sapiens	57-66
34082047-6	2021	The protective effect exerted by Ad-GPx-1 was comparable to that exerted by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor against MA insult.	pyrrolidine dithiocarbamic acid	76-103	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
34082047-6	2021	The protective effect exerted by Ad-GPx-1 was comparable to that exerted by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor against MA insult.	pyrrolidine dithiocarbamic acid	105-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
34140067-12	2021	Both BAPTA-AM and PDTC could inhibit the high expression of IL-25, IL-33 and TSLP induced by menthol.	pyrrolidine dithiocarbamic acid	18-22	interleukin 25	Homo sapiens	60-65
34140067-12	2021	Both BAPTA-AM and PDTC could inhibit the high expression of IL-25, IL-33 and TSLP induced by menthol.	pyrrolidine dithiocarbamic acid	18-22	interleukin 33	Homo sapiens	67-72
34140067-12	2021	Both BAPTA-AM and PDTC could inhibit the high expression of IL-25, IL-33 and TSLP induced by menthol.	pyrrolidine dithiocarbamic acid	18-22	thymic stromal lymphopoietin	Homo sapiens	77-81
34194560-13	2021	These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs.	pyrrolidine dithiocarbamic acid	132-159	nuclear factor kappa B subunit 1	Homo sapiens	111-120
34107901-14	2021	Pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, prevented adiponectin from ameliorating FFA-induced podocyte injury and NLRP3 activation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-41
34107901-14	2021	Pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, prevented adiponectin from ameliorating FFA-induced podocyte injury and NLRP3 activation.	pyrrolidine dithiocarbamic acid	0-27	adiponectin, C1Q and collagen domain containing	Mus musculus	63-74
34194560-13	2021	These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs.	pyrrolidine dithiocarbamic acid	132-159	interferon gamma	Homo sapiens	242-251
34107901-14	2021	Pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, prevented adiponectin from ameliorating FFA-induced podocyte injury and NLRP3 activation.	pyrrolidine dithiocarbamic acid	0-27	NLR family, pyrin domain containing 3	Mus musculus	125-130
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	204-234	defensin beta 4A	Homo sapiens	99-103
34204067-12	2021	In contrast, the NADPH oxidase inhibitor ammonium pyrrolidinedithiocarbamate (APDC) reduced the release of IL-18 but had no effect on the NLRP3 levels.	pyrrolidine dithiocarbamic acid	41-76	interleukin 18	Homo sapiens	107-112
34204067-12	2021	In contrast, the NADPH oxidase inhibitor ammonium pyrrolidinedithiocarbamate (APDC) reduced the release of IL-18 but had no effect on the NLRP3 levels.	pyrrolidine dithiocarbamic acid	78-82	interleukin 18	Homo sapiens	107-112
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	204-234	intercellular adhesion molecule 1	Homo sapiens	64-70
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	204-234	defensin beta 4A	Homo sapiens	82-97
35596974-10	2022	It was confirmed that NF-kappaB is an important factor in porcine embryos by treated ammonium pyrrolidinedithiocarbamate (APDC 0.1 muM, an inhibitor of NF-kappaB) affected NF-kappaB protein expression, IL-6 expression, and blastocyst production.	pyrrolidine dithiocarbamic acid	85-120	nuclear factor kappa B subunit 1	Homo sapiens	22-31
35596974-10	2022	It was confirmed that NF-kappaB is an important factor in porcine embryos by treated ammonium pyrrolidinedithiocarbamate (APDC 0.1 muM, an inhibitor of NF-kappaB) affected NF-kappaB protein expression, IL-6 expression, and blastocyst production.	pyrrolidine dithiocarbamic acid	85-120	nuclear factor kappa B subunit 1	Homo sapiens	152-161
35596974-10	2022	It was confirmed that NF-kappaB is an important factor in porcine embryos by treated ammonium pyrrolidinedithiocarbamate (APDC 0.1 muM, an inhibitor of NF-kappaB) affected NF-kappaB protein expression, IL-6 expression, and blastocyst production.	pyrrolidine dithiocarbamic acid	85-120	nuclear factor kappa B subunit 1	Homo sapiens	172-181
35596974-10	2022	It was confirmed that NF-kappaB is an important factor in porcine embryos by treated ammonium pyrrolidinedithiocarbamate (APDC 0.1 muM, an inhibitor of NF-kappaB) affected NF-kappaB protein expression, IL-6 expression, and blastocyst production.	pyrrolidine dithiocarbamic acid	85-120	interleukin 6	Homo sapiens	202-206
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	204-234	nuclear factor kappa B subunit 1	Homo sapiens	173-182
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	236-240	intercellular adhesion molecule 1	Homo sapiens	64-70
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	236-240	defensin beta 4A	Homo sapiens	82-97
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	236-240	defensin beta 4A	Homo sapiens	99-103
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	236-240	tumor necrosis factor	Homo sapiens	131-140
35624646-10	2022	The expression of protein intercellular cell adhesion molecule (ICAM-1) and human beta defensin-2 (HBD2) decreased when exposed to TNF-alpha and LPS, but recovered with the NF-kappaB inhibitor treatment- Pyrrolidinedithiocarbamic acid (PDTC), indicating the stability of the fabricated chip.	pyrrolidine dithiocarbamic acid	236-240	nuclear factor kappa B subunit 1	Homo sapiens	173-182
35172106-12	2022	Meanwhile, NF-kappaB pathway inhibitor pyrrolidinedithiocarbamic acid reversed the siGCN5 decreased odontogenic differentiation of DPSCs.	pyrrolidine dithiocarbamic acid	39-69	nuclear factor kappa B subunit 1	Homo sapiens	11-20
35392554-14	2022	The protein levels of nuclear factor-kappa B (NF-kappaB), hypoxia-inducible factor-1alpha (HIF-1alpha), and COL-1 were downregulated after treatment with PDTC (p < 0.05), and there was a declining trend in the protein of the connective tissue growth factor (CTGF).	pyrrolidine dithiocarbamic acid	154-158	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	58-89
35392554-14	2022	The protein levels of nuclear factor-kappa B (NF-kappaB), hypoxia-inducible factor-1alpha (HIF-1alpha), and COL-1 were downregulated after treatment with PDTC (p < 0.05), and there was a declining trend in the protein of the connective tissue growth factor (CTGF).	pyrrolidine dithiocarbamic acid	154-158	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	91-101
35392554-14	2022	The protein levels of nuclear factor-kappa B (NF-kappaB), hypoxia-inducible factor-1alpha (HIF-1alpha), and COL-1 were downregulated after treatment with PDTC (p < 0.05), and there was a declining trend in the protein of the connective tissue growth factor (CTGF).	pyrrolidine dithiocarbamic acid	154-158	cellular communication network factor 2	Rattus norvegicus	225-256
35392554-14	2022	The protein levels of nuclear factor-kappa B (NF-kappaB), hypoxia-inducible factor-1alpha (HIF-1alpha), and COL-1 were downregulated after treatment with PDTC (p < 0.05), and there was a declining trend in the protein of the connective tissue growth factor (CTGF).	pyrrolidine dithiocarbamic acid	154-158	cellular communication network factor 2	Rattus norvegicus	258-262
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	50-77	nuclear factor kappa B subunit 1	Homo sapiens	30-39
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	50-77	nuclear factor kappa B subunit 1	Homo sapiens	104-113
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	50-77	interleukin 6	Homo sapiens	123-127
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	50-77	fibroblast growth factor 23	Homo sapiens	128-133
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	79-83	nuclear factor kappa B subunit 1	Homo sapiens	30-39
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	79-83	nuclear factor kappa B subunit 1	Homo sapiens	104-113
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	79-83	interleukin 6	Homo sapiens	123-127
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	79-83	fibroblast growth factor 23	Homo sapiens	128-133
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	271-275	nuclear factor kappa B subunit 1	Homo sapiens	104-113
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	271-275	interleukin 6	Homo sapiens	123-127
35222804-8	2022	Furthermore, by utilizing the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that NF-kappaB mediated IL-6/FGF23 to regulate the Cr(VI)-induced L02 hepatocyte premature senescence, whilst the concentration of intracellular Ca2+ was not influenced by PDTC.	pyrrolidine dithiocarbamic acid	271-275	fibroblast growth factor 23	Homo sapiens	128-133
35322632-7	2022	RESULTS: The serum IL-10 level, IkBalpha and LAMP2 levels in Sal M+S, Sal H+S and PDTC+S groups were higher than those in SAP 24 h group, while all the other indexes in these three groups were all lower significantly than those in SAP 24 h group.	pyrrolidine dithiocarbamic acid	82-88	lysosomal-associated membrane protein 2	Rattus norvegicus	45-50
33469837-10	2021	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, attenuated the tumor-promoting effect of CLIC1.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	52-61
35095514-7	2021	Results: c-Fos and CBS co-expressed the most positive neurons after 1 h of restraint and immersion, followed by 3 h, and the least was at 0 h. After injection of different concentrations of NaHS into the PVN, gastric motility and gastric acid secretion in rats were significantly inhibited and promoted, respectively (p < 0.01); however, injection of normal saline, D-AP5, and PDTC did not cause any significant change (p > 0.05).	pyrrolidine dithiocarbamic acid	377-381	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	9-14
35485360-9	2021	After treatment with PDTC + TNF-alpha, the abundance of the protein for p-NF-kappaBp65 decreased and GLUT-4 increased compared with the TNF-alpha group; these values were close to those of the control group.	pyrrolidine dithiocarbamic acid	21-25	tumor necrosis factor	Homo sapiens	28-37
35485360-9	2021	After treatment with PDTC + TNF-alpha, the abundance of the protein for p-NF-kappaBp65 decreased and GLUT-4 increased compared with the TNF-alpha group; these values were close to those of the control group.	pyrrolidine dithiocarbamic acid	21-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	74-86
35485360-9	2021	After treatment with PDTC + TNF-alpha, the abundance of the protein for p-NF-kappaBp65 decreased and GLUT-4 increased compared with the TNF-alpha group; these values were close to those of the control group.	pyrrolidine dithiocarbamic acid	21-25	solute carrier family 2 member 4	Homo sapiens	101-107
34001704-12	2021	The key role of NF-kappaB was further confirmed by the application of NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	90-125	nuclear factor kappa B subunit 1	Homo sapiens	16-25
34001704-12	2021	The key role of NF-kappaB was further confirmed by the application of NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	90-125	nuclear factor kappa B subunit 1	Homo sapiens	70-79
33760170-10	2021	Pretreatment with 5 mM N-Acetyl-L-cysteine or 10 microM pyrrolidine dithiocarbamate effectively reduced cellular damage and inhibited activation of the NF-kappaB/RAGE signaling pathway.	pyrrolidine dithiocarbamic acid	56-83	advanced glycosylation end product-specific receptor	Rattus norvegicus	162-166
33925297-5	2021	Inhibition of MYC and NF-kappaB signaling using KJ-Pyr-9, dexamethasone, and pyrrolidinedithiocarbamate resulted in significant reductions in cell survival for SCC- and AC-derived cells.	pyrrolidine dithiocarbamic acid	77-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-17
33925297-5	2021	Inhibition of MYC and NF-kappaB signaling using KJ-Pyr-9, dexamethasone, and pyrrolidinedithiocarbamate resulted in significant reductions in cell survival for SCC- and AC-derived cells.	pyrrolidine dithiocarbamic acid	77-103	nuclear factor kappa B subunit 1	Homo sapiens	22-31
33882503-6	2021	Human umbilical vein endothelial cells were treated with AGE or pyrrolidinedithiocarbamate (nuclear factor kappa-B [NF-kappaB] inhibitor).	pyrrolidine dithiocarbamic acid	64-90	nuclear factor kappa B subunit 1	Homo sapiens	92-114
33882503-6	2021	Human umbilical vein endothelial cells were treated with AGE or pyrrolidinedithiocarbamate (nuclear factor kappa-B [NF-kappaB] inhibitor).	pyrrolidine dithiocarbamic acid	64-90	nuclear factor kappa B subunit 1	Homo sapiens	116-125
33728865-0	2021	PDTC ameliorates neuropathic pain by inhibiting microglial activation <em>via</em> blockage of the TNFalpha-CX3CR1 pathway.	pyrrolidine dithiocarbamic acid	0-4	tumor necrosis factor	Rattus norvegicus	99-107
33728865-0	2021	PDTC ameliorates neuropathic pain by inhibiting microglial activation <em>via</em> blockage of the TNFalpha-CX3CR1 pathway.	pyrrolidine dithiocarbamic acid	0-4	C-X3-C motif chemokine receptor 1	Rattus norvegicus	108-114
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	37-64	C-X3-C motif chemokine receptor 1	Rattus norvegicus	272-278
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	37-64	tumor necrosis factor	Rattus norvegicus	283-310
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	37-64	tumor necrosis factor	Rattus norvegicus	312-317
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	66-70	C-X3-C motif chemokine receptor 1	Rattus norvegicus	272-278
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	66-70	tumor necrosis factor	Rattus norvegicus	283-310
33728865-1	2021	Previous studies have suggested that pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappaB (NF-kappaB) inhibitor, play a role in deterring nerve injury-induced neuropathic pain (NP) The activation of NF-kappaB pathway may contribute to spinal microglial activation, CX3CR1 and tumor necrosis factor-alpha (TNF-a) up-regulation.	pyrrolidine dithiocarbamic acid	66-70	tumor necrosis factor	Rattus norvegicus	312-317
33728865-2	2021	The aim of this study was to clarify whether PDTC could inhibit the development of neuropathic pain via decreasing TNF-a-induced CX3CR1 up-regulation.	pyrrolidine dithiocarbamic acid	45-49	tumor necrosis factor	Rattus norvegicus	115-120
33728865-2	2021	The aim of this study was to clarify whether PDTC could inhibit the development of neuropathic pain via decreasing TNF-a-induced CX3CR1 up-regulation.	pyrrolidine dithiocarbamic acid	45-49	C-X3-C motif chemokine receptor 1	Rattus norvegicus	129-135
33728865-9	2021	Pain behavior and immunohistochemistry results showed that intrathecal infusion of PDTC at 100 or 1000 pmol/d prevented the development of mechanical and thermal hyperalgesia, spinal microglial activation and TNF-a expression induced by sciatic nerve CCI in rats.	pyrrolidine dithiocarbamic acid	83-87	tumor necrosis factor	Rattus norvegicus	209-214
33728865-10	2021	In vitro experiment results showed that PDTC inhibited the TNF-a-induced CX3CR1 up-regulation in BV-2 microglial cells.	pyrrolidine dithiocarbamic acid	40-44	tumor necrosis factor	Mus musculus	59-64
33728865-10	2021	In vitro experiment results showed that PDTC inhibited the TNF-a-induced CX3CR1 up-regulation in BV-2 microglial cells.	pyrrolidine dithiocarbamic acid	40-44	chemokine (C-X3-C motif) receptor 1	Mus musculus	73-79
33728865-11	2021	In conclusion, intrathecal infusion of PDTC could attenuate the pain-related behaviors induced by sciatic nerve CCI through suppressing the spinal microglia activation and TNF-a up-regulation in rats.	pyrrolidine dithiocarbamic acid	39-43	tumor necrosis factor	Rattus norvegicus	172-177
32335773-9	2021	Furthermore, inhibition of NF-kappaB by pyrrolidine dithiocarbamate inhibited OGD/R-induced NLRP3 inflammasome activation in HCN-2 cells.	pyrrolidine dithiocarbamic acid	40-67	nuclear factor kappa B subunit 1	Homo sapiens	27-36
32335773-9	2021	Furthermore, inhibition of NF-kappaB by pyrrolidine dithiocarbamate inhibited OGD/R-induced NLRP3 inflammasome activation in HCN-2 cells.	pyrrolidine dithiocarbamic acid	40-67	NLR family pyrin domain containing 3	Homo sapiens	92-97
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-35	nuclear factor kappa B subunit 1	Homo sapiens	55-77
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-35	nuclear factor kappa B subunit 1	Homo sapiens	79-88
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-35	tumor necrosis factor	Homo sapiens	153-162
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	37-41	nuclear factor kappa B subunit 1	Homo sapiens	55-77
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	37-41	nuclear factor kappa B subunit 1	Homo sapiens	79-88
33561598-7	2021	Ammonium pyrrolidinedithiocarbamate (PDTC), a specific nuclear factor kappa-B (NF-kappaB) activity blocker, significantly inhibited autophagy induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	37-41	tumor necrosis factor	Homo sapiens	153-162
33456509-7	2021	Finally, the effect of inhibiting the activation of NF-kappaB on TM was investigated using pyrrolidine dithiocarbamate (PDTC), which is a potent inhibitor of the NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	162-171
33456509-7	2021	Finally, the effect of inhibiting the activation of NF-kappaB on TM was investigated using pyrrolidine dithiocarbamate (PDTC), which is a potent inhibitor of the NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	120-124	nuclear factor kappa B subunit 1	Homo sapiens	162-171
33456509-12	2021	Following the administration of PDTC, the level of NF-kappaB and TM in the plasma were decreased significantly dose-dependently.	pyrrolidine dithiocarbamic acid	32-36	nuclear factor kappa B subunit 1	Homo sapiens	51-60
33456509-12	2021	Following the administration of PDTC, the level of NF-kappaB and TM in the plasma were decreased significantly dose-dependently.	pyrrolidine dithiocarbamic acid	32-36	thrombomodulin	Homo sapiens	65-67
33279596-9	2021	In addition, blocking NF-kappaB activation with pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) or MSCs-EVs attenuated HI-induced OPN expression in the ipsilateral cortex.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-31
33279596-9	2021	In addition, blocking NF-kappaB activation with pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) or MSCs-EVs attenuated HI-induced OPN expression in the ipsilateral cortex.	pyrrolidine dithiocarbamic acid	48-75	secreted phosphoprotein 1	Mus musculus	138-141
33279596-9	2021	In addition, blocking NF-kappaB activation with pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) or MSCs-EVs attenuated HI-induced OPN expression in the ipsilateral cortex.	pyrrolidine dithiocarbamic acid	77-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-31
33279596-9	2021	In addition, blocking NF-kappaB activation with pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) or MSCs-EVs attenuated HI-induced OPN expression in the ipsilateral cortex.	pyrrolidine dithiocarbamic acid	77-81	secreted phosphoprotein 1	Mus musculus	138-141
33469837-10	2021	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, attenuated the tumor-promoting effect of CLIC1.	pyrrolidine dithiocarbamic acid	0-27	chloride intracellular channel 1	Homo sapiens	104-109
33469837-10	2021	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, attenuated the tumor-promoting effect of CLIC1.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	52-61
33469837-10	2021	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, attenuated the tumor-promoting effect of CLIC1.	pyrrolidine dithiocarbamic acid	29-33	chloride intracellular channel 1	Homo sapiens	104-109
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	35-62	nuclear factor kappa B subunit 1	Homo sapiens	14-23
33380567-11	2021	TAK242 or NF-kappaB inhibitor pyrrolidinedithiocarbamic acid alleviated mechanical and thermal pain behaviors, inhibited spinal microglia activation, moderated spinal inflammatory response manifested by decreasing interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha expression and increasing IL-10 expression in the spinal dorsal horn.	pyrrolidine dithiocarbamic acid	30-60	interleukin 1 alpha	Rattus norvegicus	214-236
33380567-11	2021	TAK242 or NF-kappaB inhibitor pyrrolidinedithiocarbamic acid alleviated mechanical and thermal pain behaviors, inhibited spinal microglia activation, moderated spinal inflammatory response manifested by decreasing interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha expression and increasing IL-10 expression in the spinal dorsal horn.	pyrrolidine dithiocarbamic acid	30-60	interleukin 6	Rattus norvegicus	238-242
33380567-11	2021	TAK242 or NF-kappaB inhibitor pyrrolidinedithiocarbamic acid alleviated mechanical and thermal pain behaviors, inhibited spinal microglia activation, moderated spinal inflammatory response manifested by decreasing interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha expression and increasing IL-10 expression in the spinal dorsal horn.	pyrrolidine dithiocarbamic acid	30-60	tumor necrosis factor	Rattus norvegicus	244-271
33380567-11	2021	TAK242 or NF-kappaB inhibitor pyrrolidinedithiocarbamic acid alleviated mechanical and thermal pain behaviors, inhibited spinal microglia activation, moderated spinal inflammatory response manifested by decreasing interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha expression and increasing IL-10 expression in the spinal dorsal horn.	pyrrolidine dithiocarbamic acid	30-60	interleukin 10	Rattus norvegicus	298-303
33409392-8	2020	These responses were blocked in the presence of PDTC, a pharmacological inhibitor of the NF-kappaB pathway, with concomitant reduction of IkappaBalpha and cytoplasmic p65, and increased nuclear translocation of p65.	pyrrolidine dithiocarbamic acid	48-52	nuclear factor kappa B subunit 1	Homo sapiens	89-98
33409392-8	2020	These responses were blocked in the presence of PDTC, a pharmacological inhibitor of the NF-kappaB pathway, with concomitant reduction of IkappaBalpha and cytoplasmic p65, and increased nuclear translocation of p65.	pyrrolidine dithiocarbamic acid	48-52	NFKB inhibitor alpha	Homo sapiens	138-150
33409392-8	2020	These responses were blocked in the presence of PDTC, a pharmacological inhibitor of the NF-kappaB pathway, with concomitant reduction of IkappaBalpha and cytoplasmic p65, and increased nuclear translocation of p65.	pyrrolidine dithiocarbamic acid	48-52	RELA proto-oncogene, NF-kB subunit	Homo sapiens	167-170
33409392-8	2020	These responses were blocked in the presence of PDTC, a pharmacological inhibitor of the NF-kappaB pathway, with concomitant reduction of IkappaBalpha and cytoplasmic p65, and increased nuclear translocation of p65.	pyrrolidine dithiocarbamic acid	48-52	RELA proto-oncogene, NF-kB subunit	Homo sapiens	211-214
33161052-11	2020	Silencing of the TLR3 gene by RNAi or inhibition of NF-kappaB by PDTC attenuated the ethanol-induced increase in the expression of inflammatory factors in H4 cells.	pyrrolidine dithiocarbamic acid	65-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
33084337-7	2020	Also, TNF-alpha secretions promoted by YG-9 were inhibited by NF-kappaB-specific inhibitors pyrrolidine dithiocarbamate and BAY11-7082.	pyrrolidine dithiocarbamic acid	92-119	tumor necrosis factor	Mus musculus	6-15
33084337-7	2020	Also, TNF-alpha secretions promoted by YG-9 were inhibited by NF-kappaB-specific inhibitors pyrrolidine dithiocarbamate and BAY11-7082.	pyrrolidine dithiocarbamic acid	92-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	62-71
32968433-7	2020	Notably, cytokine levels decreased following the inhibition of NF-kappaB expression with pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	89-115	nuclear factor kappa B subunit 1	Homo sapiens	63-72
33488869-14	2021	Moreover, the combination of Res and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, resulted in synergistic growth inhibition of osteosarcoma.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	76-85
33488869-14	2021	Moreover, the combination of Res and pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, resulted in synergistic growth inhibition of osteosarcoma.	pyrrolidine dithiocarbamic acid	66-70	nuclear factor kappa B subunit 1	Homo sapiens	76-85
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	34-69	nuclear factor kappa B subunit 1	Homo sapiens	0-9
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	34-69	C-C motif chemokine ligand 21	Homo sapiens	110-115
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	34-69	tumor necrosis factor	Homo sapiens	143-152
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	34-69	C-C motif chemokine ligand 21	Homo sapiens	161-166
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	34-69	nuclear factor kappa B subunit 1	Homo sapiens	197-206
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	71-75	nuclear factor kappa B subunit 1	Homo sapiens	0-9
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	71-75	C-C motif chemokine ligand 21	Homo sapiens	110-115
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	71-75	tumor necrosis factor	Homo sapiens	143-152
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	71-75	C-C motif chemokine ligand 21	Homo sapiens	161-166
33158173-11	2020	NF-kappaB pathway inhibition with ammonium pyrrolidinedithiocarbamate (PDTC) caused a significant decrease in CCL21 secretion, suggesting that TNF-alpha-induced CCL21 secretion in HLEC was through NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	71-75	nuclear factor kappa B subunit 1	Homo sapiens	197-206
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	35-62	tripartite motif containing 52	Homo sapiens	82-88
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	35-62	nuclear factor kappa B subunit 1	Homo sapiens	141-150
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	64-68	nuclear factor kappa B subunit 1	Homo sapiens	14-23
33067950-0	2020	[Effect of NF-kappaB Inhibitor PDTC on Proliferation and Apoptosis of Acute Leukemia Cell HL-60].	pyrrolidine dithiocarbamic acid	31-35	nuclear factor kappa B subunit 1	Homo sapiens	11-20
32440769-0	2020	Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2.	pyrrolidine dithiocarbamic acid	0-27	NADPH oxidase 4	Rattus norvegicus	80-84
32440769-0	2020	Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	86-117
33067950-1	2020	OBJECTIVE: To explore the effect of nuclear factor kappa-B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) on the proliferation and apoptosis of acute leukemia cell HL-60.	pyrrolidine dithiocarbamic acid	81-108	nuclear factor kappa B subunit 1	Homo sapiens	36-58
33067950-1	2020	OBJECTIVE: To explore the effect of nuclear factor kappa-B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) on the proliferation and apoptosis of acute leukemia cell HL-60.	pyrrolidine dithiocarbamic acid	81-108	nuclear factor kappa B subunit 1	Homo sapiens	60-69
33067950-1	2020	OBJECTIVE: To explore the effect of nuclear factor kappa-B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) on the proliferation and apoptosis of acute leukemia cell HL-60.	pyrrolidine dithiocarbamic acid	110-114	nuclear factor kappa B subunit 1	Homo sapiens	36-58
33067950-1	2020	OBJECTIVE: To explore the effect of nuclear factor kappa-B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC) on the proliferation and apoptosis of acute leukemia cell HL-60.	pyrrolidine dithiocarbamic acid	110-114	nuclear factor kappa B subunit 1	Homo sapiens	60-69
33067950-9	2020	PDTC of 50, 100 mumol/L down-regulated the expression of p-inhibitor of NF-kappaB (p-IkappaBalpha)(P<0.01).	pyrrolidine dithiocarbamic acid	0-4	nuclear factor kappa B subunit 1	Homo sapiens	72-81
33067950-9	2020	PDTC of 50, 100 mumol/L down-regulated the expression of p-inhibitor of NF-kappaB (p-IkappaBalpha)(P<0.01).	pyrrolidine dithiocarbamic acid	0-4	NFKB inhibitor alpha	Homo sapiens	85-97
32417325-4	2020	Moreover, changes in TLR4, TIR domain-containing adaptor protein (TIRAP), NF-kB and P-gp in rBMECs were attenuated by addition of 1 mM ethyl pyruvate (EP), 10 muM TAK-242 and 10 muM pyrrolidine dithiocarbamate (PDTC), respectively.	pyrrolidine dithiocarbamic acid	182-209	TIR domain containing adaptor protein	Rattus norvegicus	66-71
32446224-11	2020	Pyrrolidine dithiocarbamate (PDTC) and dexamethasone (DXM) independently and in combination reduced pulmonary inflammation induced by the sewing machine oil by regulating MIF expression.	pyrrolidine dithiocarbamic acid	0-27	macrophage migration inhibitory factor	Rattus norvegicus	171-174
32446224-11	2020	Pyrrolidine dithiocarbamate (PDTC) and dexamethasone (DXM) independently and in combination reduced pulmonary inflammation induced by the sewing machine oil by regulating MIF expression.	pyrrolidine dithiocarbamic acid	29-33	macrophage migration inhibitory factor	Rattus norvegicus	171-174
32910705-3	2020	The inhibitors pyrrolidine dithiocarbamate (PDTC) and wortmannin were added to HK-2 cells stimulated by IL-37, and changes in PDZK1 protein were detected by western blotting.	pyrrolidine dithiocarbamic acid	15-42	interleukin 37	Homo sapiens	104-109
32910705-3	2020	The inhibitors pyrrolidine dithiocarbamate (PDTC) and wortmannin were added to HK-2 cells stimulated by IL-37, and changes in PDZK1 protein were detected by western blotting.	pyrrolidine dithiocarbamic acid	15-42	PDZ domain containing 1	Homo sapiens	126-131
32910705-3	2020	The inhibitors pyrrolidine dithiocarbamate (PDTC) and wortmannin were added to HK-2 cells stimulated by IL-37, and changes in PDZK1 protein were detected by western blotting.	pyrrolidine dithiocarbamic acid	44-48	interleukin 37	Homo sapiens	104-109
32910705-8	2020	After adding PDTC, the protein level of PDZK1 showed a trend to decrease with increasing concentrations of IL-37 up to 40 ng/mL.	pyrrolidine dithiocarbamic acid	13-17	PDZ domain containing 1	Homo sapiens	40-45
32910705-8	2020	After adding PDTC, the protein level of PDZK1 showed a trend to decrease with increasing concentrations of IL-37 up to 40 ng/mL.	pyrrolidine dithiocarbamic acid	13-17	interleukin 37	Homo sapiens	107-112
32705263-5	2020	Furthermore, ROCK1- and ROCK2-specific small interfering RNAs (siRNAs), and the NF-kappaB inhibitor ammonium pyrrolidine dithiocarbamate partially inhibited transepithelial electrical resistance in Caco-2 cells in an in vitro IEB model.	pyrrolidine dithiocarbamic acid	100-136	nuclear factor kappa B subunit 1	Homo sapiens	80-89
32295675-5	2020	TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARalpha)overexpression and the nuclear factor kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR  expression via ubiquitination-mediated proteindegradation and modification.	pyrrolidine dithiocarbamic acid	297-324	peroxisome proliferator activated receptor alpha	Homo sapiens	217-226
32295675-5	2020	TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARalpha)overexpression and the nuclear factor kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR  expression via ubiquitination-mediated proteindegradation and modification.	pyrrolidine dithiocarbamic acid	297-324	peroxisome proliferator activated receptor alpha	Homo sapiens	217-221
32295675-5	2020	TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARalpha)overexpression and the nuclear factor kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR  expression via ubiquitination-mediated proteindegradation and modification.	pyrrolidine dithiocarbamic acid	326-330	peroxisome proliferator activated receptor alpha	Homo sapiens	217-226
32295675-5	2020	TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARalpha)overexpression and the nuclear factor kappa B (NF-kappa B) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR  expression via ubiquitination-mediated proteindegradation and modification.	pyrrolidine dithiocarbamic acid	326-330	peroxisome proliferator activated receptor alpha	Homo sapiens	217-221
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	13-39	tumor necrosis factor	Rattus norvegicus	193-202
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	13-39	interleukin 6	Rattus norvegicus	204-208
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	13-39	interleukin 1 alpha	Rattus norvegicus	210-218
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	13-39	synaptotagmin 1	Rattus norvegicus	82-85
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	41-45	tumor necrosis factor	Rattus norvegicus	193-202
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	41-45	interleukin 6	Rattus norvegicus	204-208
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	41-45	interleukin 1 alpha	Rattus norvegicus	210-218
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	41-45	synaptotagmin 1	Rattus norvegicus	82-85
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	271-275	tumor necrosis factor	Rattus norvegicus	193-202
32848796-7	2020	Furthermore, pyrrolidinedithiocarbamate (PDTC, a selective inhibitor of NF-kappaB p65) not only alleviated the OGD/R-induced HBMVECs injury and permeability, but also reduced the expression of TNF-alpha, IL-6, IL-1beta, p-p65, and p-IkappaB, and the protective effect of PDTC was equivalent to that of TPPU.	pyrrolidine dithiocarbamic acid	271-275	synaptotagmin 1	Rattus norvegicus	82-85
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	64-68	tripartite motif containing 52	Homo sapiens	82-88
32898524-10	2020	Moreover, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-kappaB promoter activity in oeTRIM52 transfected RWPE-1 cells.	pyrrolidine dithiocarbamic acid	64-68	nuclear factor kappa B subunit 1	Homo sapiens	141-150
32705171-7	2020	Moreover, nucleus pulposus cells isolated from patients with IDD contained less cytoplasm compared with normal nucleus pulposus cells, and p65 expression levels were higher in the cytoplasm than the nucleus of IL-1beta-stimulated PDTC-treated healthy nucleus pulposus cells.	pyrrolidine dithiocarbamic acid	230-234	RELA proto-oncogene, NF-kB subunit	Homo sapiens	139-142
32705171-7	2020	Moreover, nucleus pulposus cells isolated from patients with IDD contained less cytoplasm compared with normal nucleus pulposus cells, and p65 expression levels were higher in the cytoplasm than the nucleus of IL-1beta-stimulated PDTC-treated healthy nucleus pulposus cells.	pyrrolidine dithiocarbamic acid	230-234	interleukin 1 alpha	Homo sapiens	210-218
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	matrix metallopeptidase 3	Homo sapiens	57-88
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	matrix metallopeptidase 13	Homo sapiens	90-96
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	121-159
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	164-172
32705171-9	2020	PDTC treatment and p53 knockdown significantly decreased matrix metallopeptidase (MMP)-3, MMP-13, metallopeptidases with thrombospondin type 1 motif (ADAMTS)-4 and ADAMTS-5 expression levels, and increased aggrecan and collagen type II expression levels in IL-1beta-stimulated cells.	pyrrolidine dithiocarbamic acid	0-4	interleukin 1 alpha	Homo sapiens	257-265
32417325-4	2020	Moreover, changes in TLR4, TIR domain-containing adaptor protein (TIRAP), NF-kB and P-gp in rBMECs were attenuated by addition of 1 mM ethyl pyruvate (EP), 10 muM TAK-242 and 10 muM pyrrolidine dithiocarbamate (PDTC), respectively.	pyrrolidine dithiocarbamic acid	211-215	TIR domain containing adaptor protein	Rattus norvegicus	66-71
32580730-13	2020	Indeed, the effects of inactivation of NF-kappaB signalling with the specific inhibitor PDTC resembled the cardioprotective effects of IkappaBalpha during H2O2 stimulation.	pyrrolidine dithiocarbamic acid	88-92	NFKB inhibitor alpha	Rattus norvegicus	135-147
32350757-4	2020	Besides, the involvement of nuclear factor kappa B (NF-kappaB) pathway was illuminated by transduction of inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	116-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-50
32492108-7	2020	Inhibiting NF-kappaB signaling activation by PDTC significantly reduced RNV.	pyrrolidine dithiocarbamic acid	45-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-20
32350757-4	2020	Besides, the involvement of nuclear factor kappa B (NF-kappaB) pathway was illuminated by transduction of inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	116-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
32350757-4	2020	Besides, the involvement of nuclear factor kappa B (NF-kappaB) pathway was illuminated by transduction of inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	145-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-50
32350757-4	2020	Besides, the involvement of nuclear factor kappa B (NF-kappaB) pathway was illuminated by transduction of inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	145-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
32240662-6	2020	Pyrrolidine dithiocarbamate and SB203580 were used to block NF-kappaB and p38 MAPK respectively, to explore the possible molecular mechanisms.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
32240662-6	2020	Pyrrolidine dithiocarbamate and SB203580 were used to block NF-kappaB and p38 MAPK respectively, to explore the possible molecular mechanisms.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 14	Mus musculus	74-82
31930775-2	2020	Pristane-induced SLE mice were treated with pyrrolidine dithiocarbamate (PDTC, 50 or 100 mg/kg), a NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	44-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
31930775-7	2020	Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment.	pyrrolidine dithiocarbamic acid	181-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	17-26
31930775-7	2020	Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment.	pyrrolidine dithiocarbamic acid	181-185	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	27-30
31930775-7	2020	Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment.	pyrrolidine dithiocarbamic acid	181-185	taurine upregulated gene 1	Mus musculus	113-117
31930775-7	2020	Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment.	pyrrolidine dithiocarbamic acid	181-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
31930775-7	2020	Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment.	pyrrolidine dithiocarbamic acid	181-185	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	143-146
31930775-9	2020	NF-kappaB inhibition with PDTC protected against the kidney injury of pristine-induced SLE mice possibly via up-regulating lncRNA TUG1, and further clinical studies are needed to clarify whether NF-kappaB inhibition may be a therapeutic modality for the kidney injury of SLE.	pyrrolidine dithiocarbamic acid	26-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
31930775-9	2020	NF-kappaB inhibition with PDTC protected against the kidney injury of pristine-induced SLE mice possibly via up-regulating lncRNA TUG1, and further clinical studies are needed to clarify whether NF-kappaB inhibition may be a therapeutic modality for the kidney injury of SLE.	pyrrolidine dithiocarbamic acid	26-30	taurine upregulated gene 1	Mus musculus	130-134
31999475-6	2020	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), alleviated UVB-induced apoptosis in HLECs; while activation of NF-kappaB suppressed the effects of the ROS inhibitor, N-acetyl-L-cysteine (NAC), on UVB-treated HLECs.	pyrrolidine dithiocarbamic acid	25-52	nuclear factor kappa B subunit 1	Homo sapiens	4-13
32018999-2	2020	Herein, a high-efficiency dithiocarbamate-modified hydrochar (DTHC) was prepared successfully and then applied to eliminate Pb(II) from aqueous solutions.	pyrrolidine dithiocarbamic acid	26-41	submaxillary gland androgen regulated protein 3B	Homo sapiens	124-130
32018999-8	2020	Fourier transform infrared spectra and X-ray photoelectron spectroscopy verified that dithiocarbamate, carboxylate, amine and sulfonate groups all facilitated the Pb(II) adsorption.	pyrrolidine dithiocarbamic acid	86-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	163-169
32344277-10	2020	Inhibition of NF-kB activation by PDTC normalizes the parameters studied.	pyrrolidine dithiocarbamic acid	34-38	nuclear factor kappa B subunit 1	Rattus norvegicus	14-19
31999475-6	2020	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), alleviated UVB-induced apoptosis in HLECs; while activation of NF-kappaB suppressed the effects of the ROS inhibitor, N-acetyl-L-cysteine (NAC), on UVB-treated HLECs.	pyrrolidine dithiocarbamic acid	25-52	X-linked Kx blood group	Homo sapiens	200-203
31999475-6	2020	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), alleviated UVB-induced apoptosis in HLECs; while activation of NF-kappaB suppressed the effects of the ROS inhibitor, N-acetyl-L-cysteine (NAC), on UVB-treated HLECs.	pyrrolidine dithiocarbamic acid	54-58	nuclear factor kappa B subunit 1	Homo sapiens	4-13
31999475-6	2020	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), alleviated UVB-induced apoptosis in HLECs; while activation of NF-kappaB suppressed the effects of the ROS inhibitor, N-acetyl-L-cysteine (NAC), on UVB-treated HLECs.	pyrrolidine dithiocarbamic acid	54-58	X-linked Kx blood group	Homo sapiens	200-203
31999475-7	2020	The expression and promoter activity of CRTAC1 was inhibited by PDTC and NAC.	pyrrolidine dithiocarbamic acid	64-68	cartilage acidic protein 1	Homo sapiens	40-46
31935902-2	2020	The APDC etchant combines with the cadmium ions (Cd2+) on the surface of the QDs, resulting in the formation of surface holes.	pyrrolidine dithiocarbamic acid	4-8	CD2 molecule	Homo sapiens	49-52
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor kappa B subunit 1	Homo sapiens	27-36
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	48-75	toll-like receptor 4	Rattus norvegicus	114-118
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	48-75	nuclear factor kappa B subunit 1	Homo sapiens	120-129
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	48-75	interleukin 6	Rattus norvegicus	133-137
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	77-81	nuclear factor kappa B subunit 1	Homo sapiens	27-36
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	77-81	toll-like receptor 4	Rattus norvegicus	114-118
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	77-81	nuclear factor kappa B subunit 1	Homo sapiens	120-129
32116790-7	2020	Chronic treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), prevented activation of renal TLR4, NF-kappaB or IL-6, without interfering with blood glucose.	pyrrolidine dithiocarbamic acid	77-81	interleukin 6	Rattus norvegicus	133-137
32166663-4	2020	Streptozotocin (STZ)-induced type 1 diabetic rats were treated with pyrrolidine dithiocarbamate (PDTC) or meisoindigo (Me) to inhibit NF-kappaB and Wnt/beta-catenm/GSK3beta respectively for 4 or 8 weeks.	pyrrolidine dithiocarbamic acid	68-95	glycogen synthase kinase 3 alpha	Rattus norvegicus	164-172
31701354-8	2020	Expression of IL-23, phospho-NF-kappaB p65, and phospho-IkappaBalpha was upregulated in colon tissues of the MCMV-infected mice compared to mock inoculum-treated mice, while treatment with PDTC attenuated colonic IL-23 production.	pyrrolidine dithiocarbamic acid	189-193	interleukin 23, alpha subunit p19	Mus musculus	14-19
31974591-5	2020	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, and wortmannin, an inhibitor of PI3K, both decreased the proportion of viable A549 cells in the presence of Polyphyllin VII.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	52-61
31974591-5	2020	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, and wortmannin, an inhibitor of PI3K, both decreased the proportion of viable A549 cells in the presence of Polyphyllin VII.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	52-61
31756335-12	2020	Similar results were observed after triptolide cotreatment with the NF-kappaB inhibitor, ammonium pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	89-124	nuclear factor kappa B subunit 1	Homo sapiens	68-77
31756335-12	2020	Similar results were observed after triptolide cotreatment with the NF-kappaB inhibitor, ammonium pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	126-130	nuclear factor kappa B subunit 1	Homo sapiens	68-77
31853279-5	2020	The increase in cell proliferation induced by RGC32 could be abolished by the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	98-125	regulator of cell cycle	Homo sapiens	46-51
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	28-59	nuclear factor kappa B subunit 1	Homo sapiens	67-76
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	28-59	C-C motif chemokine ligand 4	Homo sapiens	112-116
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	28-59	nuclear factor kappa B subunit 1	Homo sapiens	125-134
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	28-59	ATP binding cassette subfamily C member 2	Homo sapiens	158-162
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	61-65	nuclear factor kappa B subunit 1	Homo sapiens	67-76
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	61-65	C-C motif chemokine ligand 4	Homo sapiens	112-116
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	61-65	nuclear factor kappa B subunit 1	Homo sapiens	125-134
31976833-7	2020	Moreover, pretreatment with pyrrolidine dithiocarbamic acid (PDTC; NF-kappaB inhibitor) significantly inhibited CCl4-induced NF-kappaB activation and reduced MRP2 protein expression (1+-0.097 vs. 0.623+-0.054; P &lt; 0.05).	pyrrolidine dithiocarbamic acid	61-65	ATP binding cassette subfamily C member 2	Homo sapiens	158-162
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	215-242	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31837574-7	2020	Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	207-234	NFKB inhibitor alpha	Rattus norvegicus	73-85
31837574-7	2020	Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	207-234	interleukin 1 beta	Rattus norvegicus	91-99
31837574-7	2020	Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	207-234	interleukin 1 beta	Rattus norvegicus	141-149
31837574-7	2020	Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	236-240	interleukin 1 beta	Rattus norvegicus	141-149
32015687-9	2020	Pyrrolidine dithiocarbamate treatment reversed the CNH-induced increase in miR-335-3p expression and diminished CNH-induced PAH.	pyrrolidine dithiocarbamic acid	0-27	microRNA 335	Mus musculus	75-82
31746430-7	2020	PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co-administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF-kappaB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)-alpha, bile salt export pump (BSEP), and protein expression of BSEP.	pyrrolidine dithiocarbamic acid	0-4	tumor necrosis factor	Rattus norvegicus	243-276
31746430-7	2020	PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co-administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF-kappaB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)-alpha, bile salt export pump (BSEP), and protein expression of BSEP.	pyrrolidine dithiocarbamic acid	0-4	ATP binding cassette subfamily B member 11	Rattus norvegicus	278-299
31746430-7	2020	PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co-administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF-kappaB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)-alpha, bile salt export pump (BSEP), and protein expression of BSEP.	pyrrolidine dithiocarbamic acid	0-4	ATP binding cassette subfamily B member 11	Rattus norvegicus	301-305
31746430-7	2020	PDTC (50 mg/kg/day) was intraperitoneally injected 2 h after the co-administration of INH and RIF to compare liver biochemical indicators in the serum, histopathological damage, NF-kappaB activity, oxidative stress, hepatic mRNA expression of tumor necrosis factor (TNF)-alpha, bile salt export pump (BSEP), and protein expression of BSEP.	pyrrolidine dithiocarbamic acid	0-4	ATP binding cassette subfamily B member 11	Rattus norvegicus	334-338
31746430-8	2020	It was found that the inhibition of NF-kappaB activation by PDTC treatment markedly alleviated liver biochemical and histological injury, decreased oxidative stress and mRNA levels of TNF-alpha, and prevented decreases in BSEP mRNA and protein expression induced by the co-administration of INH and RIF.	pyrrolidine dithiocarbamic acid	60-64	tumor necrosis factor	Rattus norvegicus	184-193
31746430-8	2020	It was found that the inhibition of NF-kappaB activation by PDTC treatment markedly alleviated liver biochemical and histological injury, decreased oxidative stress and mRNA levels of TNF-alpha, and prevented decreases in BSEP mRNA and protein expression induced by the co-administration of INH and RIF.	pyrrolidine dithiocarbamic acid	60-64	ATP binding cassette subfamily B member 11	Rattus norvegicus	222-226
31746430-10	2020	PDTC exerted a therapeutic effect on INH/RIF-induced liver injury by increasing BSEP expression, and exhibiting antioxidant and anti-inflammatory activities.	pyrrolidine dithiocarbamic acid	0-4	ATP binding cassette subfamily B member 11	Rattus norvegicus	80-84
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	215-242	dual specificity phosphatase 19	Mus musculus	13-19
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	215-242	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	244-248	dual specificity phosphatase 19	Mus musculus	13-19
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	244-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	pyrrolidine dithiocarbamic acid	244-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31934265-10	2019	Pyrrolidine dithiocarbamate (PDTC) treatment before stretch also reduced TGF-beta expression.	pyrrolidine dithiocarbamic acid	0-27	transforming growth factor beta 1	Homo sapiens	73-81
31934265-10	2019	Pyrrolidine dithiocarbamate (PDTC) treatment before stretch also reduced TGF-beta expression.	pyrrolidine dithiocarbamic acid	29-33	transforming growth factor beta 1	Homo sapiens	73-81
31140621-10	2019	Moreover, both the NF-kappaB selected inhibitor pyrrolidinedithiocarbamate ammonium and P38/MAPK specific inhibitor SB203580 partly reversed lncRNA-ATB induced glioma cells invasion mediated by TGF-beta.	pyrrolidine dithiocarbamic acid	48-83	transforming growth factor beta 1	Homo sapiens	194-202
31690106-6	2019	Furthermore, in cultured pancreatic beta cells, exposure to high levels of glucose or palmitic acid significantly increased expression and current density of the KCa3.1 channel as well as secretion of proinflammatory chemokines, and the effects were similarly reversed by preincubation with TRAM-34 or a NF-kappaB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	324-350	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	162-168
31650850-5	2019	After ammonium pyrrolidine dithiocarbamate (PDTC) treatment, the NF-kappaBp65 expression was reduced in U87 cells, and AVP could raise these effects.	pyrrolidine dithiocarbamic acid	6-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	65-77
31132609-5	2019	Monolayer cultured cells (2D) and multicellular spheroids (3D) experiments proved that PDTC could reverse multidrug resistance (MDR), improve intracellular drugs accumulation and enhance tumor penetration by down-regulating the expression of P-gp, then resulting in higher DOX-induced cytotoxicity and apoptosis in MCF-7 and MCF-7/ADR cells.	pyrrolidine dithiocarbamic acid	87-91	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	128-131
31688605-9	2019	RESULTS: NF-kappaB was activated by TNF-alpha and suppressed by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	64-91	nuclear factor kappa B subunit 1	Homo sapiens	9-18
31415760-7	2019	Inhibition of either p38-MAPK or NF-kappaB using specific inhibitors (SB203580, SB202190 or Bay11-7082, pyrrolidinedithiocarbamate) attenuated PA-induced downregulation of KCa2.3 and inhibition of p38-MAPK also attenuated PA-induced phosphorylation of NF-kappaB p65.	pyrrolidine dithiocarbamic acid	104-130	mitogen-activated protein kinase 14	Homo sapiens	21-24
31415760-7	2019	Inhibition of either p38-MAPK or NF-kappaB using specific inhibitors (SB203580, SB202190 or Bay11-7082, pyrrolidinedithiocarbamate) attenuated PA-induced downregulation of KCa2.3 and inhibition of p38-MAPK also attenuated PA-induced phosphorylation of NF-kappaB p65.	pyrrolidine dithiocarbamic acid	104-130	potassium calcium-activated channel subfamily N member 3	Homo sapiens	172-178
31553199-0	2019	Photocatalyst-Free Visible-Light-Promoted C(sp2)-S Coupling: A Strategy for the Preparation of S-Aryl Dithiocarbamates.	pyrrolidine dithiocarbamic acid	95-118	Sp2 transcription factor	Homo sapiens	42-47
31132609-5	2019	Monolayer cultured cells (2D) and multicellular spheroids (3D) experiments proved that PDTC could reverse multidrug resistance (MDR), improve intracellular drugs accumulation and enhance tumor penetration by down-regulating the expression of P-gp, then resulting in higher DOX-induced cytotoxicity and apoptosis in MCF-7 and MCF-7/ADR cells.	pyrrolidine dithiocarbamic acid	87-91	phosphoglycolate phosphatase	Homo sapiens	242-246
31285514-7	2019	Inhibition of NF-kappaB activity by ammonium pyrrolidinedithiocarbamate (PDTC) suppressed DOX-induced cardiomyocyte apoptosis.	pyrrolidine dithiocarbamic acid	36-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
31175933-5	2019	Furthermore, micro-injection of the NF-kappaB inhibitor pyrrolidine dithiocarbamate into PVN in MI rats, significantly inhibited the activation of NF-kappaB and further reduced the expression of IL-1beta and NGF in the PVN, finally blunting sympathetic hyperinnervation in the heart, moreover, the blockade of NF-kappaB in the PVN reduced the incidence of ventricular arrhythmias (VAs).	pyrrolidine dithiocarbamic acid	56-83	interleukin 1 beta	Rattus norvegicus	195-203
31199046-2	2019	The mRNA and protein expression of CXCL16 and CXCR6 was detected after lipopolysaccharide (LPS) stimulation with or without treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	187-214	C-X-C motif chemokine ligand 16	Homo sapiens	35-41
31199046-2	2019	The mRNA and protein expression of CXCL16 and CXCR6 was detected after lipopolysaccharide (LPS) stimulation with or without treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	187-214	C-X-C motif chemokine receptor 6	Homo sapiens	46-51
31199046-2	2019	The mRNA and protein expression of CXCL16 and CXCR6 was detected after lipopolysaccharide (LPS) stimulation with or without treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	216-220	C-X-C motif chemokine ligand 16	Homo sapiens	35-41
31199046-2	2019	The mRNA and protein expression of CXCL16 and CXCR6 was detected after lipopolysaccharide (LPS) stimulation with or without treatment with the nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	216-220	C-X-C motif chemokine receptor 6	Homo sapiens	46-51
31199046-9	2019	The results of the luciferase assay further demonstrated that PDTC treatment markedly inhibited the activity of the CXCL16 promoter.	pyrrolidine dithiocarbamic acid	62-66	C-X-C motif chemokine ligand 16	Homo sapiens	116-122
31285514-7	2019	Inhibition of NF-kappaB activity by ammonium pyrrolidinedithiocarbamate (PDTC) suppressed DOX-induced cardiomyocyte apoptosis.	pyrrolidine dithiocarbamic acid	73-77	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
31059705-7	2019	Pyrrolidine dithiocarbamate (PDTC), an NFkappaB inhibitor, was more effective in attenuating cocaine-induced reproductive toxicity in GPx-1 KO than in WT mice.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-47
31059705-7	2019	Pyrrolidine dithiocarbamate (PDTC), an NFkappaB inhibitor, was more effective in attenuating cocaine-induced reproductive toxicity in GPx-1 KO than in WT mice.	pyrrolidine dithiocarbamic acid	0-27	glutathione peroxidase 1	Mus musculus	134-139
31059705-7	2019	Pyrrolidine dithiocarbamate (PDTC), an NFkappaB inhibitor, was more effective in attenuating cocaine-induced reproductive toxicity in GPx-1 KO than in WT mice.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-47
31059705-7	2019	Pyrrolidine dithiocarbamate (PDTC), an NFkappaB inhibitor, was more effective in attenuating cocaine-induced reproductive toxicity in GPx-1 KO than in WT mice.	pyrrolidine dithiocarbamic acid	29-33	glutathione peroxidase 1	Mus musculus	134-139
31214026-9	2019	Induction of proinflammatory and catabolic mediators by IL-1beta stimulation of mouse chondrocytes could be partially blocked by treatment with nobiletin or ammonium pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	157-193	interleukin 1 beta	Mus musculus	56-64
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	22-48	interleukin 1 beta	Mus musculus	102-110
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	22-48	interleukin 1 beta	Mus musculus	158-166
30288996-10	2019	Pharmacologic inhibition of Nf-kb signaling pathway by PDTC could significantly reduce the expression levels of p53 and the size of HO, and the reduction was most significant in the 0.6mg dosage group.	pyrrolidine dithiocarbamic acid	55-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	28-33
30288996-10	2019	Pharmacologic inhibition of Nf-kb signaling pathway by PDTC could significantly reduce the expression levels of p53 and the size of HO, and the reduction was most significant in the 0.6mg dosage group.	pyrrolidine dithiocarbamic acid	55-59	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115
30288996-12	2019	Inhibition of Nf-kb signaling pathway by PDTC could significantly reduce HO formation, and the most effective concentration was 6 mg/ml for local injection.	pyrrolidine dithiocarbamic acid	41-45	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	14-19
31056982-8	2019	However, NF-kappaB signaling pathway was inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, the anti-inflammatory effect of osthole was abolished.	pyrrolidine dithiocarbamic acid	54-81	nuclear factor kappa B subunit 1	Homo sapiens	9-18
31056982-8	2019	However, NF-kappaB signaling pathway was inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, the anti-inflammatory effect of osthole was abolished.	pyrrolidine dithiocarbamic acid	54-81	nuclear factor kappa B subunit 1	Homo sapiens	93-102
31056982-8	2019	However, NF-kappaB signaling pathway was inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, the anti-inflammatory effect of osthole was abolished.	pyrrolidine dithiocarbamic acid	83-87	nuclear factor kappa B subunit 1	Homo sapiens	9-18
31056982-8	2019	However, NF-kappaB signaling pathway was inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, the anti-inflammatory effect of osthole was abolished.	pyrrolidine dithiocarbamic acid	83-87	nuclear factor kappa B subunit 1	Homo sapiens	93-102
30790627-10	2019	Treatment of the models with a nuclear factor inhibitor, PDTC, further induced the expression of TREM2 and enhanced microglial phagocytosis, coincident with the rapid reduction in plaque burden.	pyrrolidine dithiocarbamic acid	57-61	triggering receptor expressed on myeloid cells 2	Mus musculus	97-102
29534626-5	2018	NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) was injected (intraperitoneal) before the final two focal TCE challenges.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
30597662-2	2019	The present results showed HCG induced VEGF expression as well as hypoxia-inducible factor (HIF)-1alpha mRNA and protein expressions, which was blocked by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	175-202	vascular endothelial growth factor A	Homo sapiens	39-43
30597662-2	2019	The present results showed HCG induced VEGF expression as well as hypoxia-inducible factor (HIF)-1alpha mRNA and protein expressions, which was blocked by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	175-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-103
30597662-2	2019	The present results showed HCG induced VEGF expression as well as hypoxia-inducible factor (HIF)-1alpha mRNA and protein expressions, which was blocked by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	175-202	nuclear factor kappa B subunit 1	Homo sapiens	155-164
30597662-2	2019	The present results showed HCG induced VEGF expression as well as hypoxia-inducible factor (HIF)-1alpha mRNA and protein expressions, which was blocked by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	204-208	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-103
30597662-2	2019	The present results showed HCG induced VEGF expression as well as hypoxia-inducible factor (HIF)-1alpha mRNA and protein expressions, which was blocked by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	204-208	nuclear factor kappa B subunit 1	Homo sapiens	155-164
30685319-6	2019	Pyrrolidine dithiocarbamate (PDTC), a NFkappaB inhibitor, significantly attenuated the sensitivity induced by the genetic depletion of GPx-1 in mice.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-46
30685319-6	2019	Pyrrolidine dithiocarbamate (PDTC), a NFkappaB inhibitor, significantly attenuated the sensitivity induced by the genetic depletion of GPx-1 in mice.	pyrrolidine dithiocarbamic acid	0-27	glutathione peroxidase 1	Mus musculus	135-140
30685319-6	2019	Pyrrolidine dithiocarbamate (PDTC), a NFkappaB inhibitor, significantly attenuated the sensitivity induced by the genetic depletion of GPx-1 in mice.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-46
30685319-6	2019	Pyrrolidine dithiocarbamate (PDTC), a NFkappaB inhibitor, significantly attenuated the sensitivity induced by the genetic depletion of GPx-1 in mice.	pyrrolidine dithiocarbamic acid	29-33	glutathione peroxidase 1	Mus musculus	135-140
30745862-9	2019	Pyrrolidine dithiocarbamate changed the expression of Beclin-1, LC3, and p65 in the intestines.	pyrrolidine dithiocarbamic acid	0-27	beclin 1	Rattus norvegicus	54-62
30745862-9	2019	Pyrrolidine dithiocarbamate changed the expression of Beclin-1, LC3, and p65 in the intestines.	pyrrolidine dithiocarbamic acid	0-27	annexin A3	Rattus norvegicus	64-67
30745862-9	2019	Pyrrolidine dithiocarbamate changed the expression of Beclin-1, LC3, and p65 in the intestines.	pyrrolidine dithiocarbamic acid	0-27	synaptotagmin 1	Rattus norvegicus	73-76
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	84-111	toll like receptor 4	Homo sapiens	1-5
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	21-32
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	84-111	mitogen-activated protein kinase 14	Homo sapiens	37-40
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	131-142
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	113-117	toll like receptor 4	Homo sapiens	1-5
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	113-117	nuclear factor kappa B subunit 1	Homo sapiens	21-32
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	113-117	mitogen-activated protein kinase 14	Homo sapiens	37-40
30612458-6	2019	(TLR4)-mediated both NF- kappa B and p38 signaling, as demonstrated by the usage of pyrrolidine dithiocarbamate (PDTC), a specific NF- kappa B inhibitor.	pyrrolidine dithiocarbamic acid	113-117	nuclear factor kappa B subunit 1	Homo sapiens	131-142
30394176-7	2019	NF-kappaB pathway inhibitor pyrrolidine dithiocarbamate significantly attenuated Zn-CuONPs induced apoptosis and autophagy.	pyrrolidine dithiocarbamic acid	28-55	nuclear factor kappa B subunit 1	Homo sapiens	0-9
30319075-11	2019	Moreover, this temperature-induced p53 induction was inhibited on exposure to 40 C in the presence of NF-kappaB pathway inhibitor, pyrrolidinedithiocarbamate (PDTC) or endonuclease-prepared small interfering RNA (esiRNA) targeting p65.	pyrrolidine dithiocarbamic acid	131-157	tumor protein p53	Homo sapiens	35-38
30319075-11	2019	Moreover, this temperature-induced p53 induction was inhibited on exposure to 40 C in the presence of NF-kappaB pathway inhibitor, pyrrolidinedithiocarbamate (PDTC) or endonuclease-prepared small interfering RNA (esiRNA) targeting p65.	pyrrolidine dithiocarbamic acid	159-163	tumor protein p53	Homo sapiens	35-38
30587127-5	2018	SP600125, SB203580 and ammonium pyrrolidinedithiocarbamate (PDTC) were used to inhibit JNK1/2, p38MAPK and NF-kappaB signalling pathways in septic cell model, respectively.	pyrrolidine dithiocarbamic acid	23-58	mitogen-activated protein kinase 8	Homo sapiens	87-93
30587127-5	2018	SP600125, SB203580 and ammonium pyrrolidinedithiocarbamate (PDTC) were used to inhibit JNK1/2, p38MAPK and NF-kappaB signalling pathways in septic cell model, respectively.	pyrrolidine dithiocarbamic acid	60-64	mitogen-activated protein kinase 8	Homo sapiens	87-93
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	91-118	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-80
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	91-118	caspase 3	Mus musculus	156-165
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	91-118	caspase 3	Mus musculus	211-220
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	120-124	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-80
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	120-124	caspase 3	Mus musculus	156-165
30442365-7	2018	Furthermore, flow cytometry and western blot analysis revealed that the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore the DEX-induced caspase-3 decrease and inhibit the DEX-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	120-124	caspase 3	Mus musculus	211-220
30915775-10	2019	The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage.	pyrrolidine dithiocarbamic acid	24-51	solute carrier family 1 member 2	Homo sapiens	211-217
30915775-10	2019	The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage.	pyrrolidine dithiocarbamic acid	24-51	tumor necrosis factor	Homo sapiens	251-260
30915775-10	2019	The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage.	pyrrolidine dithiocarbamic acid	53-57	solute carrier family 1 member 2	Homo sapiens	211-217
30915775-10	2019	The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage.	pyrrolidine dithiocarbamic acid	53-57	tumor necrosis factor	Homo sapiens	251-260
31935733-6	2019	Then, expression of E-cadherin was significantly down-regulated, while levels of N-cadherin, vimentin, beta-catenin, Snail, p-p65 and p-IkappaBalpha were significantly up-regulated, which was reversed by PDTC (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	204-208	cadherin 1	Homo sapiens	20-30
31935733-6	2019	Then, expression of E-cadherin was significantly down-regulated, while levels of N-cadherin, vimentin, beta-catenin, Snail, p-p65 and p-IkappaBalpha were significantly up-regulated, which was reversed by PDTC (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	210-237	cadherin 1	Homo sapiens	20-30
30571738-8	2018	Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb.	pyrrolidine dithiocarbamic acid	149-176	interleukin 6	Homo sapiens	44-48
30571738-8	2018	Finally, anti-Sm mAb still up-regulated the IL-6 production of monocytes in the presence of anti-RNP mAb under the influence of N-acetyl cysteine or pyrrolidine dithiocarbamate that totally abrogated the IL-6 production provoked by anti-Sm mAb alone in the absence of anti-RNP mAb.	pyrrolidine dithiocarbamic acid	149-176	interleukin 6	Homo sapiens	204-208
29534626-5	2018	NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) was injected (intraperitoneal) before the final two focal TCE challenges.	pyrrolidine dithiocarbamic acid	49-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
29577638-10	2018	Inhibition of NF-kB signaling using p65 inhibitor pyrrolidine dithiocarbamate significantly prevented the increases of the CXCR4 expression.	pyrrolidine dithiocarbamic acid	50-77	synaptotagmin 1	Rattus norvegicus	36-39
29772587-6	2018	Pretreated with pyrrolidine dithiocarbamate, the effect of cardamonin on the mammalian target of rapamycin signalling was not affected, but the expression of inflammatory factors was further reduced.	pyrrolidine dithiocarbamic acid	16-43	mechanistic target of rapamycin kinase	Homo sapiens	77-106
30365118-6	2018	NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and PKC inhibitor Chelerythrine were used to block these two signaling pathways.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
30365118-6	2018	NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and PKC inhibitor Chelerythrine were used to block these two signaling pathways.	pyrrolidine dithiocarbamic acid	49-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
30595795-0	2018	Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappaB/iNOS Pathway.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	114-118
30595795-0	2018	Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-kappaB/iNOS Pathway.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2	Rattus norvegicus	114-118
30468489-12	2018	The levels of TNF-alpha, IL-1beta, IL-6 and IL-8 in PDTC group were significantly lower than in OL group (p<0.05).	pyrrolidine dithiocarbamic acid	52-56	tumor necrosis factor	Rattus norvegicus	14-23
30468489-12	2018	The levels of TNF-alpha, IL-1beta, IL-6 and IL-8 in PDTC group were significantly lower than in OL group (p<0.05).	pyrrolidine dithiocarbamic acid	52-56	interleukin 1 alpha	Rattus norvegicus	25-33
30468489-12	2018	The levels of TNF-alpha, IL-1beta, IL-6 and IL-8 in PDTC group were significantly lower than in OL group (p<0.05).	pyrrolidine dithiocarbamic acid	52-56	interleukin 6	Rattus norvegicus	35-39
29577638-10	2018	Inhibition of NF-kB signaling using p65 inhibitor pyrrolidine dithiocarbamate significantly prevented the increases of the CXCR4 expression.	pyrrolidine dithiocarbamic acid	50-77	C-X-C motif chemokine receptor 4	Rattus norvegicus	123-128
30085340-7	2018	Meanwhile, the NF-kappabeta p65 inhibitor ammonium pyrrolidinedithiocarbamate and the ERK1/2 inhibitor U0126, but not the p38 inhibitor SB203580, were able to block oxLDL/beta2GPI/anti-beta2GPI complex-induced foam cell formation and migration in A7r5 cells.	pyrrolidine dithiocarbamic acid	42-77	synaptotagmin 1	Rattus norvegicus	28-31
30076769-8	2018	Genetic overexpression of GPx-1 or NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated MCLR-induced hippocampal neuronal loss in mice.	pyrrolidine dithiocarbamic acid	54-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-43
30076769-8	2018	Genetic overexpression of GPx-1 or NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated MCLR-induced hippocampal neuronal loss in mice.	pyrrolidine dithiocarbamic acid	83-87	glutathione peroxidase 1	Mus musculus	26-31
30076769-8	2018	Genetic overexpression of GPx-1 or NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated MCLR-induced hippocampal neuronal loss in mice.	pyrrolidine dithiocarbamic acid	83-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-43
30085340-7	2018	Meanwhile, the NF-kappabeta p65 inhibitor ammonium pyrrolidinedithiocarbamate and the ERK1/2 inhibitor U0126, but not the p38 inhibitor SB203580, were able to block oxLDL/beta2GPI/anti-beta2GPI complex-induced foam cell formation and migration in A7r5 cells.	pyrrolidine dithiocarbamic acid	42-77	apolipoprotein H	Rattus norvegicus	171-179
30085340-7	2018	Meanwhile, the NF-kappabeta p65 inhibitor ammonium pyrrolidinedithiocarbamate and the ERK1/2 inhibitor U0126, but not the p38 inhibitor SB203580, were able to block oxLDL/beta2GPI/anti-beta2GPI complex-induced foam cell formation and migration in A7r5 cells.	pyrrolidine dithiocarbamic acid	42-77	apolipoprotein H	Rattus norvegicus	185-193
30010631-9	2018	In supporting the notion that CCRP repressed the LPS-induced NFkappaB signaling, pretreatment with pyrrolidinedithiocarbamate, an NFkappaB signaling inhibitor, or anti-TNF-alpha antibody before LPS treatment restored heart rates decreased in KO mice after LPS treatment in a dose-dependent manner.	pyrrolidine dithiocarbamic acid	99-125	DnaJ heat shock protein family (Hsp40) member C7	Mus musculus	30-34
30347940-14	2018	Ammonium pyrrolidine dithiocarbamate partly reversed CHT1 upregulation and alleviated colonic hypermotility in WAS rats.	pyrrolidine dithiocarbamic acid	0-36	solute carrier family 5 member 7	Rattus norvegicus	53-57
30179628-8	2018	Suppression of NF-kappaB by pyrrolidine dithiocarbamate (PDTC) also reduced cyclin D1 expression in PAH model.	pyrrolidine dithiocarbamic acid	28-55	cyclin D1	Rattus norvegicus	76-85
30179628-8	2018	Suppression of NF-kappaB by pyrrolidine dithiocarbamate (PDTC) also reduced cyclin D1 expression in PAH model.	pyrrolidine dithiocarbamic acid	57-61	cyclin D1	Rattus norvegicus	76-85
30288092-13	2018	CHT1 upregulation in the WAS-exposed group was largely abolished by ammonium pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	68-103	solute carrier family 5 member 7	Rattus norvegicus	0-4
29858554-5	2018	Using the novelty-suppressed feeding (NSF) and elevated-plus maze (EPM) tests, we found that treatment with pyrrolidine dithiocarbamate (PDTC; intra-hippocampal infusion), an inhibitor of NF-kappaB, rescued the CMS- or glucocorticoid-induced anxiogenic behaviors in mice.	pyrrolidine dithiocarbamic acid	108-135	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-197
29858554-5	2018	Using the novelty-suppressed feeding (NSF) and elevated-plus maze (EPM) tests, we found that treatment with pyrrolidine dithiocarbamate (PDTC; intra-hippocampal infusion), an inhibitor of NF-kappaB, rescued the CMS- or glucocorticoid-induced anxiogenic behaviors in mice.	pyrrolidine dithiocarbamic acid	137-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-197
29577638-10	2018	Inhibition of NF-kB signaling using p65 inhibitor pyrrolidine dithiocarbamate significantly prevented the increases of the CXCR4 expression.	pyrrolidine dithiocarbamic acid	50-77	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	14-19
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	238-265	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-22
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	238-265	NLR family, pyrin domain containing 3	Mus musculus	68-73
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	267-271	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-22
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	267-271	NLR family, pyrin domain containing 3	Mus musculus	68-73
30010631-9	2018	In supporting the notion that CCRP repressed the LPS-induced NFkappaB signaling, pretreatment with pyrrolidinedithiocarbamate, an NFkappaB signaling inhibitor, or anti-TNF-alpha antibody before LPS treatment restored heart rates decreased in KO mice after LPS treatment in a dose-dependent manner.	pyrrolidine dithiocarbamic acid	99-125	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-69
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	14-23
29789998-6	2018	Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	168-195	tumor necrosis factor	Homo sapiens	26-34
29789998-6	2018	Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	168-195	X protein	Hepatitis B virus	73-76
29789998-6	2018	Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	197-201	tumor necrosis factor	Homo sapiens	26-34
29789998-6	2018	Pro-inflammatory cytokine TNFalpha also induced AX800134 upregulation in HBx-expressing HepG2 cells, which could be reversed by reactive oxygen species (ROS) scavenger pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	197-201	X protein	Hepatitis B virus	73-76
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	88-97
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	27-54	thioredoxin	Homo sapiens	283-287
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	56-60	nuclear factor kappa B subunit 1	Homo sapiens	14-23
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	56-60	nuclear factor kappa B subunit 1	Homo sapiens	88-97
29677534-9	2018	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation.	pyrrolidine dithiocarbamic acid	56-60	thioredoxin	Homo sapiens	283-287
29426532-2	2018	It utilizes a pre-heated customized glass tube (CGT), to supply the heat energy required for the reaction of Cr(III) with ammonium pyrrolidinedithiocarbamate (APDC).	pyrrolidine dithiocarbamic acid	122-157	UDP glycosyltransferase 8	Homo sapiens	48-51
29930535-15	2018	The upregulation effect of PAQR3 overexpression on the expressions of FN and ICAM-1 was abolished by the treatment of NF-kappaB siRNA or PDTC (ammonium pyrrolidinedithiocarbamate) in HG-treated GMCs.	pyrrolidine dithiocarbamic acid	143-178	progestin and adipoQ receptor family member 3	Rattus norvegicus	27-32
29930535-15	2018	The upregulation effect of PAQR3 overexpression on the expressions of FN and ICAM-1 was abolished by the treatment of NF-kappaB siRNA or PDTC (ammonium pyrrolidinedithiocarbamate) in HG-treated GMCs.	pyrrolidine dithiocarbamic acid	143-178	intercellular adhesion molecule 1	Rattus norvegicus	77-83
29950992-9	2018	The negative effects of TNF-alpha on chondrocytes can be partially blocked by treating with icariin or ammonium pyrrolidinedithiocarbamate (PDTC, an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	103-138	tumor necrosis factor	Rattus norvegicus	24-33
29950992-9	2018	The negative effects of TNF-alpha on chondrocytes can be partially blocked by treating with icariin or ammonium pyrrolidinedithiocarbamate (PDTC, an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	140-144	tumor necrosis factor	Rattus norvegicus	24-33
28934999-2	2018	Ammonium pyrrolidinedithiocarbamate was used as a ligand to make a hydrophobic complex of Cd+2, which was extracted in an ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate), and the nonionic surfactant Triton X-114 was applied as a dispersing medium.	pyrrolidine dithiocarbamic acid	0-35	CD2 molecule	Homo sapiens	90-94
29940243-12	2018	Pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, prevented the response not only in TNF-alpha-treated cardiomyocytes but also in H/R-treated group.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	94-103
29940243-12	2018	Pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, prevented the response not only in TNF-alpha-treated cardiomyocytes but also in H/R-treated group.	pyrrolidine dithiocarbamic acid	29-33	tumor necrosis factor	Rattus norvegicus	94-103
29188532-7	2018	Furthermore, NF-kappaB inhibitor pyrrolidine dithiocarbamate or PKC inhibitor chelerythrine could effectively inhibit the LPS-induced expression of c-myc and endogenous beta-glucuronidase, and the expression of p-p65 was also partly inhibited by chelerythrine.	pyrrolidine dithiocarbamic acid	33-60	nuclear factor kappa B subunit 1	Homo sapiens	13-22
29188532-7	2018	Furthermore, NF-kappaB inhibitor pyrrolidine dithiocarbamate or PKC inhibitor chelerythrine could effectively inhibit the LPS-induced expression of c-myc and endogenous beta-glucuronidase, and the expression of p-p65 was also partly inhibited by chelerythrine.	pyrrolidine dithiocarbamic acid	33-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	148-153
29188532-7	2018	Furthermore, NF-kappaB inhibitor pyrrolidine dithiocarbamate or PKC inhibitor chelerythrine could effectively inhibit the LPS-induced expression of c-myc and endogenous beta-glucuronidase, and the expression of p-p65 was also partly inhibited by chelerythrine.	pyrrolidine dithiocarbamic acid	33-60	glucuronidase beta	Homo sapiens	169-187
28946816-8	2018	The NFkappaB participation in TNF-alpha effect on adiponectin expression was assayed using an NFkappaB inhibitor (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	114-141	nuclear factor kappa B subunit 1	Homo sapiens	4-12
28946816-8	2018	The NFkappaB participation in TNF-alpha effect on adiponectin expression was assayed using an NFkappaB inhibitor (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	114-141	tumor necrosis factor	Homo sapiens	30-39
28946816-8	2018	The NFkappaB participation in TNF-alpha effect on adiponectin expression was assayed using an NFkappaB inhibitor (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	114-141	adiponectin, C1Q and collagen domain containing	Homo sapiens	50-61
28946816-8	2018	The NFkappaB participation in TNF-alpha effect on adiponectin expression was assayed using an NFkappaB inhibitor (pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	114-141	nuclear factor kappa B subunit 1	Homo sapiens	94-102
29881400-7	2018	Pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-kappaB, was used to confirm the associated signaling pathway.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	51-60
29881400-7	2018	Pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-kappaB, was used to confirm the associated signaling pathway.	pyrrolidine dithiocarbamic acid	28-32	nuclear factor kappa B subunit 1	Homo sapiens	51-60
29863269-1	2018	OBJECTIVE: To investigate the effects of an inhibitor of NF-kappaB, PDTC (pyrrolidine dithiocarbamate), on TLR4 (Toll-like receptor 4) expression in the left ventricle of Goldblatt hypertension rats.	pyrrolidine dithiocarbamic acid	74-101	toll-like receptor 4	Rattus norvegicus	107-111
29863269-1	2018	OBJECTIVE: To investigate the effects of an inhibitor of NF-kappaB, PDTC (pyrrolidine dithiocarbamate), on TLR4 (Toll-like receptor 4) expression in the left ventricle of Goldblatt hypertension rats.	pyrrolidine dithiocarbamic acid	74-101	toll-like receptor 4	Rattus norvegicus	113-133
29426532-2	2018	It utilizes a pre-heated customized glass tube (CGT), to supply the heat energy required for the reaction of Cr(III) with ammonium pyrrolidinedithiocarbamate (APDC).	pyrrolidine dithiocarbamic acid	159-163	UDP glycosyltransferase 8	Homo sapiens	48-51
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	162-193	vimentin	Rattus norvegicus	34-42
29525670-5	2018	Blocking NF-kappaB signaling in PK-15 cells overexpressing Hsp27 by ammonium pyrrolidinedithiocarbamate (PDTC) eliminated the inhibition of CSFV replication by Hsp27.	pyrrolidine dithiocarbamic acid	68-103	heat shock protein beta-1	Sus scrofa	59-64
29525670-5	2018	Blocking NF-kappaB signaling in PK-15 cells overexpressing Hsp27 by ammonium pyrrolidinedithiocarbamate (PDTC) eliminated the inhibition of CSFV replication by Hsp27.	pyrrolidine dithiocarbamic acid	68-103	heat shock protein beta-1	Sus scrofa	160-165
29525670-5	2018	Blocking NF-kappaB signaling in PK-15 cells overexpressing Hsp27 by ammonium pyrrolidinedithiocarbamate (PDTC) eliminated the inhibition of CSFV replication by Hsp27.	pyrrolidine dithiocarbamic acid	105-109	heat shock protein beta-1	Sus scrofa	59-64
29525670-5	2018	Blocking NF-kappaB signaling in PK-15 cells overexpressing Hsp27 by ammonium pyrrolidinedithiocarbamate (PDTC) eliminated the inhibition of CSFV replication by Hsp27.	pyrrolidine dithiocarbamic acid	105-109	heat shock protein beta-1	Sus scrofa	160-165
29933681-10	2018	The specific inhibitor of NF-kappaB, pyrrolidinedithiocarbamate (PDTC) could also significantly inhibit the expressions of p-p65 and p-IkappaBalpha with and alleviate liver injuries.	pyrrolidine dithiocarbamic acid	37-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
29933681-10	2018	The specific inhibitor of NF-kappaB, pyrrolidinedithiocarbamate (PDTC) could also significantly inhibit the expressions of p-p65 and p-IkappaBalpha with and alleviate liver injuries.	pyrrolidine dithiocarbamic acid	37-63	lymphocyte cytosolic protein 1	Mus musculus	123-128
29933681-10	2018	The specific inhibitor of NF-kappaB, pyrrolidinedithiocarbamate (PDTC) could also significantly inhibit the expressions of p-p65 and p-IkappaBalpha with and alleviate liver injuries.	pyrrolidine dithiocarbamic acid	65-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
29933681-10	2018	The specific inhibitor of NF-kappaB, pyrrolidinedithiocarbamate (PDTC) could also significantly inhibit the expressions of p-p65 and p-IkappaBalpha with and alleviate liver injuries.	pyrrolidine dithiocarbamic acid	65-69	lymphocyte cytosolic protein 1	Mus musculus	123-128
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	162-193	D-box binding PAR bZIP transcription factor	Rattus norvegicus	68-71
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	162-193	synaptotagmin 1	Rattus norvegicus	116-119
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	195-199	vimentin	Rattus norvegicus	34-42
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	195-199	D-box binding PAR bZIP transcription factor	Rattus norvegicus	68-71
30310660-7	2018	Additionally, steroidogenesis and vimentin expression stimulated by DBP were blocked when the activity of NF-kappaB p65 was inhibited by the NF-kappaB inhibitor, pyrrolidine dithiocarbamic acid (PDTC).	pyrrolidine dithiocarbamic acid	195-199	synaptotagmin 1	Rattus norvegicus	116-119
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	107-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	107-134	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	48-51
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	107-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	136-140	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	136-140	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	48-51
29044685-8	2018	CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	136-140	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
29044685-10	2018	CPA caused the overexpression of CSE in the bladder, and this was prevented by PDTC or curcumin.	pyrrolidine dithiocarbamic acid	79-83	cystathionase (cystathionine gamma-lyase)	Mus musculus	33-36
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	nuclear factor kappa B subunit 1	Homo sapiens	162-171
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	BCL2 associated X, apoptosis regulator	Homo sapiens	467-470
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	nuclear factor kappa B subunit 1	Homo sapiens	162-171
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	RELA proto-oncogene, NF-kB subunit	Homo sapiens	172-175
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	caspase 3	Homo sapiens	267-276
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	BCL2 associated X, apoptosis regulator	Homo sapiens	281-284
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	tumor necrosis factor	Homo sapiens	295-322
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	tumor necrosis factor	Homo sapiens	324-333
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	nuclear factor kappa B subunit 1	Homo sapiens	400-409
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	RELA proto-oncogene, NF-kB subunit	Homo sapiens	410-413
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	caspase 3	Homo sapiens	453-462
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	120-124	BCL2 associated X, apoptosis regulator	Homo sapiens	467-470
29131380-7	2018	Expression of the Klotho protein was diminished by LPS and was restored by 5-Aza-2"-deoxycytidine (5-Aza-2"-dc), AMI-1, and ammonium pyrrolidinedithiocarbamate (PDTC), but not adenosine aldehyde (AdOx).	pyrrolidine dithiocarbamic acid	124-159	klotho	Mus musculus	18-24
29131380-7	2018	Expression of the Klotho protein was diminished by LPS and was restored by 5-Aza-2"-deoxycytidine (5-Aza-2"-dc), AMI-1, and ammonium pyrrolidinedithiocarbamate (PDTC), but not adenosine aldehyde (AdOx).	pyrrolidine dithiocarbamic acid	161-165	klotho	Mus musculus	18-24
29552116-9	2018	Pretreatment with pyrrolidine dithiocarbamate (PDTC), the inhibitor of NF-kappaB, prevented the decrease in cell proliferation and apoptosis induced by CDK5RAP1 deficiency in A375 cells.	pyrrolidine dithiocarbamic acid	18-45	nuclear factor kappa B subunit 1	Homo sapiens	71-80
29552116-9	2018	Pretreatment with pyrrolidine dithiocarbamate (PDTC), the inhibitor of NF-kappaB, prevented the decrease in cell proliferation and apoptosis induced by CDK5RAP1 deficiency in A375 cells.	pyrrolidine dithiocarbamic acid	18-45	CDK5 regulatory subunit associated protein 1	Homo sapiens	152-160
29552116-9	2018	Pretreatment with pyrrolidine dithiocarbamate (PDTC), the inhibitor of NF-kappaB, prevented the decrease in cell proliferation and apoptosis induced by CDK5RAP1 deficiency in A375 cells.	pyrrolidine dithiocarbamic acid	47-51	nuclear factor kappa B subunit 1	Homo sapiens	71-80
29552116-9	2018	Pretreatment with pyrrolidine dithiocarbamate (PDTC), the inhibitor of NF-kappaB, prevented the decrease in cell proliferation and apoptosis induced by CDK5RAP1 deficiency in A375 cells.	pyrrolidine dithiocarbamic acid	47-51	CDK5 regulatory subunit associated protein 1	Homo sapiens	152-160
29329420-0	2018	Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis.	pyrrolidine dithiocarbamic acid	0-27	BCL2 like 1	Homo sapiens	37-43
29329420-3	2018	Here, we show that co-treatment with pyrrolidine dithiocarbamate (PDTC) attenuates DOX-induced apoptosis in Chang-L liver cells and human hepatocytes, but overcomes DOX resistance in Bcl-xL-overexpressing Chang-L cells and several hepatocellular carcinoma (HCC) cell lines with high Bcl-xL expression.	pyrrolidine dithiocarbamic acid	37-64	BCL2 like 1	Homo sapiens	183-189
29329420-3	2018	Here, we show that co-treatment with pyrrolidine dithiocarbamate (PDTC) attenuates DOX-induced apoptosis in Chang-L liver cells and human hepatocytes, but overcomes DOX resistance in Bcl-xL-overexpressing Chang-L cells and several hepatocellular carcinoma (HCC) cell lines with high Bcl-xL expression.	pyrrolidine dithiocarbamic acid	37-64	BCL2 like 1	Homo sapiens	283-289
29329420-3	2018	Here, we show that co-treatment with pyrrolidine dithiocarbamate (PDTC) attenuates DOX-induced apoptosis in Chang-L liver cells and human hepatocytes, but overcomes DOX resistance in Bcl-xL-overexpressing Chang-L cells and several hepatocellular carcinoma (HCC) cell lines with high Bcl-xL expression.	pyrrolidine dithiocarbamic acid	66-70	BCL2 like 1	Homo sapiens	183-189
29329420-3	2018	Here, we show that co-treatment with pyrrolidine dithiocarbamate (PDTC) attenuates DOX-induced apoptosis in Chang-L liver cells and human hepatocytes, but overcomes DOX resistance in Bcl-xL-overexpressing Chang-L cells and several hepatocellular carcinoma (HCC) cell lines with high Bcl-xL expression.	pyrrolidine dithiocarbamic acid	66-70	BCL2 like 1	Homo sapiens	283-289
29329420-5	2018	These results suggest that DOX/PDTC co-treatment may provide a safe and effective therapeutic strategy against malignant hepatoma cells with Bcl-xL-mediated apoptotic defects.	pyrrolidine dithiocarbamic acid	31-35	BCL2 like 1	Homo sapiens	141-147
29329420-7	2018	The intracellular glutathione levels were reduced in Bcl-xL-overexpressing Chang-L cells treated with DOX/PDTC, and DOX/PDTC-induced paraptosis was effectively blocked by pretreatment with thiol-antioxidants, but not by non-thiol antioxidants.	pyrrolidine dithiocarbamic acid	106-110	BCL2 like 1	Homo sapiens	53-59
29329420-7	2018	The intracellular glutathione levels were reduced in Bcl-xL-overexpressing Chang-L cells treated with DOX/PDTC, and DOX/PDTC-induced paraptosis was effectively blocked by pretreatment with thiol-antioxidants, but not by non-thiol antioxidants.	pyrrolidine dithiocarbamic acid	120-124	BCL2 like 1	Homo sapiens	53-59
29329420-8	2018	Collectively, our results suggest that disruption of thiol homeostasis may critically contribute to DOX/PDTC-induced paraptosis in Bcl-xL-overexpressing cells.	pyrrolidine dithiocarbamic acid	104-108	BCL2 like 1	Homo sapiens	131-137
29122692-8	2018	Consistently, NF-kappaB activation was significantly protected by the PAF-R antagonist, ginkgolide B (Gink B), in PAF-R knockout mice and by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	166-193	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
29122692-8	2018	Consistently, NF-kappaB activation was significantly protected by the PAF-R antagonist, ginkgolide B (Gink B), in PAF-R knockout mice and by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	166-193	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
29122692-8	2018	Consistently, NF-kappaB activation was significantly protected by the PAF-R antagonist, ginkgolide B (Gink B), in PAF-R knockout mice and by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	195-199	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
29122692-8	2018	Consistently, NF-kappaB activation was significantly protected by the PAF-R antagonist, ginkgolide B (Gink B), in PAF-R knockout mice and by the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	195-199	platelet-activating factor receptor	Mus musculus	70-75
29286074-15	2018	The high dose of cbFeD reversed the effect of pyrrolidine dithiocarbamate, a p65-inhibitor, on the expression of p65, LC3B-I, LC3B-II and Beclin-1, and on the production of autophagic vacuoles.	pyrrolidine dithiocarbamic acid	46-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	77-80
29286074-15	2018	The high dose of cbFeD reversed the effect of pyrrolidine dithiocarbamate, a p65-inhibitor, on the expression of p65, LC3B-I, LC3B-II and Beclin-1, and on the production of autophagic vacuoles.	pyrrolidine dithiocarbamic acid	46-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	113-116
29286074-15	2018	The high dose of cbFeD reversed the effect of pyrrolidine dithiocarbamate, a p65-inhibitor, on the expression of p65, LC3B-I, LC3B-II and Beclin-1, and on the production of autophagic vacuoles.	pyrrolidine dithiocarbamic acid	46-73	beclin 1	Homo sapiens	138-146
29344652-10	2018	Inhbition of nuclear factor (NF)-kappaB by ammonium pyrrolidine dithiocarbamate diminished the effect of chrysophanol on apoptosis and associated proteins.	pyrrolidine dithiocarbamic acid	43-79	nuclear factor kappa B subunit 1	Homo sapiens	13-39
29252510-10	2018	Pyrrolidinedithiocarbamate alleviates ischemia-induced neuronal injury and hippocampal-dependent cognitive impairment by inhibiting increases in N-Myc downstream-regulated gene-2 expression and N-Myc downstream-regulated gene-2-mediated inflammation.	pyrrolidine dithiocarbamic acid	0-26	N-myc downstream regulated gene 2	Mus musculus	145-178
29252510-10	2018	Pyrrolidinedithiocarbamate alleviates ischemia-induced neuronal injury and hippocampal-dependent cognitive impairment by inhibiting increases in N-Myc downstream-regulated gene-2 expression and N-Myc downstream-regulated gene-2-mediated inflammation.	pyrrolidine dithiocarbamic acid	0-26	N-myc downstream regulated gene 2	Mus musculus	194-227
29232759-9	2018	CYP1B1 induction is inhibited by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate (100 muM) but not by the HIF1alpha inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (50 muM).	pyrrolidine dithiocarbamic acid	57-92	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
29232759-9	2018	CYP1B1 induction is inhibited by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate (100 muM) but not by the HIF1alpha inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (50 muM).	pyrrolidine dithiocarbamic acid	57-92	latexin	Homo sapiens	98-101
28976017-0	2018	Early administration of pyrrolidine dithiocarbamate extends the therapeutic time window of tissue plasminogen activator in a male rat model of embolic stroke.	pyrrolidine dithiocarbamic acid	24-51	plasminogen activator, tissue type	Rattus norvegicus	91-119
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	RELA proto-oncogene, NF-kB subunit	Homo sapiens	172-175
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	caspase 3	Homo sapiens	267-276
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	BCL2 associated X, apoptosis regulator	Homo sapiens	281-284
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	tumor necrosis factor	Homo sapiens	295-322
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	tumor necrosis factor	Homo sapiens	324-333
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	nuclear factor kappa B subunit 1	Homo sapiens	400-409
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	RELA proto-oncogene, NF-kB subunit	Homo sapiens	410-413
29545865-7	2018	Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells.	pyrrolidine dithiocarbamic acid	88-118	caspase 3	Homo sapiens	453-462
28612319-8	2018	Administration of either the NF-kappaB inhibitor ammonium pyrrolidine dithiocarbamate or a CX3CR1-neutralizing antibody blocked the development and maintenance of neuropathic pain.	pyrrolidine dithiocarbamic acid	49-85	nuclear factor kappa B subunit 1	Homo sapiens	29-38
28488777-5	2018	Pyrrolidinedithiocarbamic acid (PDTC, 60 microM), a specific NF-kappaB inhibitor, abated NF-kappaB activation that rendered the adipocytes vulnerable to TNFalpha-induced apoptosis.	pyrrolidine dithiocarbamic acid	0-30	tumor necrosis factor	Homo sapiens	153-161
28488777-5	2018	Pyrrolidinedithiocarbamic acid (PDTC, 60 microM), a specific NF-kappaB inhibitor, abated NF-kappaB activation that rendered the adipocytes vulnerable to TNFalpha-induced apoptosis.	pyrrolidine dithiocarbamic acid	32-36	tumor necrosis factor	Homo sapiens	153-161
28857167-12	2018	Pyrrolidine dithiocarbamate blocked the activation of NF-kappaB signaling induced by TNF-alpha, while it prevented the downregulation of Runx2, BSP and EphB4, induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Mus musculus	85-94
28857167-12	2018	Pyrrolidine dithiocarbamate blocked the activation of NF-kappaB signaling induced by TNF-alpha, while it prevented the downregulation of Runx2, BSP and EphB4, induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	runt related transcription factor 2	Mus musculus	137-142
28857167-12	2018	Pyrrolidine dithiocarbamate blocked the activation of NF-kappaB signaling induced by TNF-alpha, while it prevented the downregulation of Runx2, BSP and EphB4, induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	Eph receptor B4	Mus musculus	152-157
28857167-12	2018	Pyrrolidine dithiocarbamate blocked the activation of NF-kappaB signaling induced by TNF-alpha, while it prevented the downregulation of Runx2, BSP and EphB4, induced by TNF-alpha.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Mus musculus	170-179
30001532-8	2018	The inflammatory NF-kappaB pathway is required for the activation of Hh signaling, as blockade of the NF-kappaB pathway by pyrrolidine dithiocarbamate impaired the Gli2 upregulation.	pyrrolidine dithiocarbamic acid	123-150	GLI-Kruppel family member GLI2	Mus musculus	164-168
28986307-8	2018	Dual luciferase and gel-shift assays and chromatin immunoprecipitation-polymerase chain reaction demonstrated that IL-1beta and TNF-alpha enhanced ASIC1a promoter activity in chondrocytes by increasing NF-kappaB DNA-binding activities, which was in turn prevented by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	291-326	interleukin 1 beta	Rattus norvegicus	115-123
28986307-8	2018	Dual luciferase and gel-shift assays and chromatin immunoprecipitation-polymerase chain reaction demonstrated that IL-1beta and TNF-alpha enhanced ASIC1a promoter activity in chondrocytes by increasing NF-kappaB DNA-binding activities, which was in turn prevented by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	291-326	tumor necrosis factor	Rattus norvegicus	128-137
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	20-47	nuclear factor kappa B subunit 1	Rattus norvegicus	4-9
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	20-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	20-47	heme oxygenase 1	Rattus norvegicus	96-100
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	49-53	nuclear factor kappa B subunit 1	Rattus norvegicus	4-9
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	49-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
29161661-7	2018	The NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) increased Nrf2 nuclear translocation and HO-1 expression and antioxidant levels.	pyrrolidine dithiocarbamic acid	49-53	heme oxygenase 1	Rattus norvegicus	96-100
29055802-3	2017	Gefitinib (GBTC) and pyrrolidine dithiocarbamate (PDTC) are capable of inhibiting EGFR/NOD2 and NF-kB, respectively.	pyrrolidine dithiocarbamic acid	21-48	epidermal growth factor receptor	Homo sapiens	82-86
29055802-3	2017	Gefitinib (GBTC) and pyrrolidine dithiocarbamate (PDTC) are capable of inhibiting EGFR/NOD2 and NF-kB, respectively.	pyrrolidine dithiocarbamic acid	21-48	nucleotide binding oligomerization domain containing 2	Homo sapiens	87-91
29055802-3	2017	Gefitinib (GBTC) and pyrrolidine dithiocarbamate (PDTC) are capable of inhibiting EGFR/NOD2 and NF-kB, respectively.	pyrrolidine dithiocarbamic acid	50-54	epidermal growth factor receptor	Homo sapiens	82-86
29055802-3	2017	Gefitinib (GBTC) and pyrrolidine dithiocarbamate (PDTC) are capable of inhibiting EGFR/NOD2 and NF-kB, respectively.	pyrrolidine dithiocarbamic acid	50-54	nucleotide binding oligomerization domain containing 2	Homo sapiens	87-91
29089476-9	2017	Pyrrolidine dithiocarbamate (PDTC) was used to block the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	71-80
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	0-27	regulator of calcineurin 1	Homo sapiens	85-120
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	0-27	regulator of calcineurin 1	Homo sapiens	122-127
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	0-27	regulator of calcineurin 1	Homo sapiens	174-179
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	29-33	regulator of calcineurin 1	Homo sapiens	85-120
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	29-33	regulator of calcineurin 1	Homo sapiens	122-127
28712932-0	2017	Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.	pyrrolidine dithiocarbamic acid	29-33	regulator of calcineurin 1	Homo sapiens	174-179
29039510-6	2017	In addition, the association between NF-kappaB and DNMT1 was examined by treatment of the ECs with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	99-126	nuclear factor kappa B subunit 1	Homo sapiens	37-46
29039510-6	2017	In addition, the association between NF-kappaB and DNMT1 was examined by treatment of the ECs with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	99-126	DNA methyltransferase 1	Homo sapiens	51-56
29039510-6	2017	In addition, the association between NF-kappaB and DNMT1 was examined by treatment of the ECs with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	128-132	nuclear factor kappa B subunit 1	Homo sapiens	37-46
29039510-6	2017	In addition, the association between NF-kappaB and DNMT1 was examined by treatment of the ECs with pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	128-132	DNA methyltransferase 1	Homo sapiens	51-56
29089476-9	2017	Pyrrolidine dithiocarbamate (PDTC) was used to block the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	71-80
28755171-8	2017	The NF-kappaB/p65 inhibitor pyrrolidine dithiocarbamate achieved similar anti-apoptosis effects.	pyrrolidine dithiocarbamic acid	28-55	RELA proto-oncogene, NF-kB subunit	Homo sapiens	14-17
28901421-8	2017	Subsequent experiments confirmed that the p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, and nuclear factor (NF)-kappaB inhibitor, pyrrolidine dithiocarbamate, eliminated the uric acid-induced expression of TNF-alpha.	pyrrolidine dithiocarbamic acid	149-176	tumor necrosis factor	Rattus norvegicus	225-234
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	35-62	interleukin 6	Homo sapiens	80-84
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	35-62	interleukin 1 beta	Homo sapiens	86-94
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	35-62	tumor necrosis factor	Homo sapiens	100-109
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	35-62	thrombospondin 1	Homo sapiens	150-155
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	64-68	interleukin 6	Homo sapiens	80-84
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	64-68	interleukin 1 beta	Homo sapiens	86-94
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	64-68	tumor necrosis factor	Homo sapiens	100-109
28634844-8	2017	Additional experiments showed that Pyrrolidine dithiocarbamate (PDTC) inhibited IL-6, IL-1beta, and TNF-alpha expression induced by overexpression of TSP-1, accompanying with downregulation of phosphorylated p65 and IkappaBalpha protein levels in response to P. gingivalis LPS.	pyrrolidine dithiocarbamic acid	64-68	thrombospondin 1	Homo sapiens	150-155
27925186-8	2017	TNF-alpha did not change p-ERK1/2 levels, but increased the phosphorylation and nuclear localization of nuclear factor-kappaB (NF-kappaB), which were blocked by the NF-kappaB inhibitors BAY 11-7082 and pyrrolidinedithiocarbamate ammonium.	pyrrolidine dithiocarbamic acid	202-237	tumor necrosis factor	Homo sapiens	0-9
28700093-7	2017	Pyrrolidinedithiocarbamate, an inhibitor of NFkappaB activation, reduced the IL-10 expression levels in both OGD-injured astrocytes in vitro and the hippocampi of HIBD rats in vivo but did not significantly affect TLR2 expression.	pyrrolidine dithiocarbamic acid	0-26	interleukin 10	Rattus norvegicus	77-82
28836571-9	2017	CLI-095 or PDTC administration suppressed proinflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) production and macrophage infiltration into the kidney (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	11-15	tumor necrosis factor	Mus musculus	68-77
28836571-9	2017	CLI-095 or PDTC administration suppressed proinflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) production and macrophage infiltration into the kidney (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	11-15	interleukin 6	Mus musculus	79-83
28836571-9	2017	CLI-095 or PDTC administration suppressed proinflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) production and macrophage infiltration into the kidney (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	11-15	interleukin 1 beta	Mus musculus	89-97
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	120-147	solute carrier family 16 member 3	Rattus norvegicus	16-20
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	120-147	arginine vasopressin	Rattus norvegicus	47-50
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	120-147	nuclear factor kappa B subunit 1	Rattus norvegicus	103-108
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	149-153	solute carrier family 16 member 3	Rattus norvegicus	16-20
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	149-153	arginine vasopressin	Rattus norvegicus	47-50
28865453-13	2017	The increase of MCT4 protein expression during AVP treatment was blocked by the addition of a specific NF-kB inhibitor, pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	149-153	nuclear factor kappa B subunit 1	Rattus norvegicus	103-108
28931847-4	2017	LPS and pyrrolidine dithiocarbamate (PDTC) were administered to activate the TLR4/NF-kappaB pathway and selectively block the activation of NF-kappaB, respectively.	pyrrolidine dithiocarbamic acid	8-35	toll-like receptor 4	Rattus norvegicus	77-81
28931847-4	2017	LPS and pyrrolidine dithiocarbamate (PDTC) were administered to activate the TLR4/NF-kappaB pathway and selectively block the activation of NF-kappaB, respectively.	pyrrolidine dithiocarbamic acid	37-41	toll-like receptor 4	Rattus norvegicus	77-81
28484848-6	2017	Further study indicated that the presence of either NF-kappaB inhibitor pyrrolidinedithiocarbamate or prior silencing miR-27a/b with anti-miRNA oligonucleotides suppressed ET-1-induced PPARgamma reduction and proliferation of PASMC, while overexpression of miR-27a/b reduced PPARgamma expression and enhanced PASMC proliferation.	pyrrolidine dithiocarbamic acid	72-98	endothelin 1	Rattus norvegicus	172-176
28484848-6	2017	Further study indicated that the presence of either NF-kappaB inhibitor pyrrolidinedithiocarbamate or prior silencing miR-27a/b with anti-miRNA oligonucleotides suppressed ET-1-induced PPARgamma reduction and proliferation of PASMC, while overexpression of miR-27a/b reduced PPARgamma expression and enhanced PASMC proliferation.	pyrrolidine dithiocarbamic acid	72-98	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	185-194
28109078-5	2017	Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of nuclear factor-kappaB (NF-kappaB) pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	195-199	3-phosphoinositide dependent protein kinase 1	Homo sapiens	30-35
28712788-8	2017	As a contrast, the specific inhibitor of NF-kappaB pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as ARS on phosphorylation of p65 and IkappaBalpha, and serum levels of aminotransferases.	pyrrolidine dithiocarbamic acid	51-78	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	151-154
28712788-8	2017	As a contrast, the specific inhibitor of NF-kappaB pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as ARS on phosphorylation of p65 and IkappaBalpha, and serum levels of aminotransferases.	pyrrolidine dithiocarbamic acid	80-84	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	151-154
28712788-8	2017	As a contrast, the specific inhibitor of NF-kappaB pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as ARS on phosphorylation of p65 and IkappaBalpha, and serum levels of aminotransferases.	pyrrolidine dithiocarbamic acid	80-84	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	159-171
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	0-4	MYD88 innate immune signal transduction adaptor	Homo sapiens	86-91
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	0-4	nuclear factor kappa B subunit 1	Homo sapiens	92-101
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	0-4	mitogen-activated protein kinase 14	Homo sapiens	109-112
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	0-4	NLR family pyrin domain containing 3	Homo sapiens	117-122
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	6-36	MYD88 innate immune signal transduction adaptor	Homo sapiens	86-91
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	6-36	nuclear factor kappa B subunit 1	Homo sapiens	92-101
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	6-36	mitogen-activated protein kinase 14	Homo sapiens	109-112
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	6-36	NLR family pyrin domain containing 3	Homo sapiens	117-122
28668606-3	2017	PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88/NF-kappaB, MAPKs/p38 and NLRP3/Caspase-1 pathway, respectively.	pyrrolidine dithiocarbamic acid	6-36	caspase 1	Homo sapiens	123-132
28527816-10	2017	In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	22-30
28527816-10	2017	In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor kappa B subunit 1	Homo sapiens	59-67
28527816-10	2017	In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown.	pyrrolidine dithiocarbamic acid	84-111	interleukin 1 beta	Homo sapiens	123-131
28527816-10	2017	In addition, blocking NFkappaB signaling with the specific NFkappaB inhibitor PDTC (pyrrolidine dithiocarbamate) prevented IL-1beta-induced HUVEC activation enhanced by ADAR1 knockdown.	pyrrolidine dithiocarbamic acid	84-111	adenosine deaminase RNA specific	Homo sapiens	169-174
28385482-7	2017	Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	14-23
29137283-6	2017	Western blotting showed that the specific NF-kappaB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARgamma/LXRalpha markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively.	pyrrolidine dithiocarbamic acid	70-106	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
29137283-6	2017	Western blotting showed that the specific NF-kappaB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARgamma/LXRalpha markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively.	pyrrolidine dithiocarbamic acid	70-106	C1q and tumor necrosis factor related protein 3	Mus musculus	218-223
29137283-6	2017	Western blotting showed that the specific NF-kappaB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARgamma/LXRalpha markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively.	pyrrolidine dithiocarbamic acid	108-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
29137283-6	2017	Western blotting showed that the specific NF-kappaB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARgamma/LXRalpha markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively.	pyrrolidine dithiocarbamic acid	108-112	nuclear receptor subfamily 1, group H, member 3	Mus musculus	143-151
29137283-6	2017	Western blotting showed that the specific NF-kappaB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARgamma/LXRalpha markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively.	pyrrolidine dithiocarbamic acid	108-112	C1q and tumor necrosis factor related protein 3	Mus musculus	218-223
28385482-7	2017	Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin.	pyrrolidine dithiocarbamic acid	27-54	vimentin	Homo sapiens	142-150
28385482-7	2017	Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin.	pyrrolidine dithiocarbamic acid	56-60	nuclear factor kappa B subunit 1	Homo sapiens	14-23
28385482-7	2017	Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin.	pyrrolidine dithiocarbamic acid	56-60	vimentin	Homo sapiens	142-150
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	55-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
28672898-3	2017	It was observed by reverse transcription-quantitative polymerase chain reaction and western blot analysis that APS and the specific inhibitor of nuclear factor (NF)-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly reduced the expression of atrogin-1, ubiquitin and the NF-kappaB subunit p65 mRNA in rat skeletal muscle in vivo and in vitro, respectively (P&lt;0.05).	pyrrolidine dithiocarbamic acid	173-200	F-box protein 32	Rattus norvegicus	249-258
28672898-3	2017	It was observed by reverse transcription-quantitative polymerase chain reaction and western blot analysis that APS and the specific inhibitor of nuclear factor (NF)-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly reduced the expression of atrogin-1, ubiquitin and the NF-kappaB subunit p65 mRNA in rat skeletal muscle in vivo and in vitro, respectively (P&lt;0.05).	pyrrolidine dithiocarbamic acid	173-200	synaptotagmin 1	Rattus norvegicus	296-299
28672898-3	2017	It was observed by reverse transcription-quantitative polymerase chain reaction and western blot analysis that APS and the specific inhibitor of nuclear factor (NF)-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly reduced the expression of atrogin-1, ubiquitin and the NF-kappaB subunit p65 mRNA in rat skeletal muscle in vivo and in vitro, respectively (P&lt;0.05).	pyrrolidine dithiocarbamic acid	202-206	F-box protein 32	Rattus norvegicus	249-258
28672898-3	2017	It was observed by reverse transcription-quantitative polymerase chain reaction and western blot analysis that APS and the specific inhibitor of nuclear factor (NF)-kappaB, pyrrolidine dithiocarbamate (PDTC), significantly reduced the expression of atrogin-1, ubiquitin and the NF-kappaB subunit p65 mRNA in rat skeletal muscle in vivo and in vitro, respectively (P&lt;0.05).	pyrrolidine dithiocarbamic acid	202-206	synaptotagmin 1	Rattus norvegicus	296-299
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	55-82	tumor necrosis factor	Mus musculus	129-138
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	55-82	interleukin 6	Mus musculus	143-147
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	55-82	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	188-194
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	84-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	84-88	tumor necrosis factor	Mus musculus	129-138
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	84-88	interleukin 6	Mus musculus	143-147
28498464-6	2017	Our data also showed that inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC) significantly reduced the secretion of TNF-alpha and IL-6 from BV-2 microglial cells treated with S100A8/A9.	pyrrolidine dithiocarbamic acid	84-88	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	188-194
28647191-0	2017	Pyrrolidine dithiocarbamate alleviates the anti-tuberculosis drug-induced liver injury through JAK2/STAT3 signaling pathway: An experimental study.	pyrrolidine dithiocarbamic acid	0-27	Janus kinase 2	Rattus norvegicus	95-99
28647191-0	2017	Pyrrolidine dithiocarbamate alleviates the anti-tuberculosis drug-induced liver injury through JAK2/STAT3 signaling pathway: An experimental study.	pyrrolidine dithiocarbamic acid	0-27	signal transducer and activator of transcription 3	Rattus norvegicus	100-105
28339078-4	2017	Pyrrolidine dithiocarbamate (PDTC; 50 microM) was used to inhibit the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	84-93
26797516-6	2017	Pharmacological inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC; 50 muM) or quinazoline (QNZ; 10 muM) also abolished TGF-alpha promoter activity, and NF-kappaB directly bound to its consensus site in the TGF-alpha promoter as evidenced by electrophoretic mobility shift assay (EMSA).	pyrrolidine dithiocarbamic acid	45-72	transforming growth factor alpha	Homo sapiens	132-141
28339080-6	2017	In addition, CCR7-siRNA inactivated the NF-kappaB signaling pathway and inhibition of NF-kappaB via its specific antagonist, pyrrolidine dithiocarbamate, indicated that NF-kappaB was involved in the CCR7-mediated apoptosis.	pyrrolidine dithiocarbamic acid	125-152	C-C motif chemokine receptor 7	Homo sapiens	13-17
28339080-6	2017	In addition, CCR7-siRNA inactivated the NF-kappaB signaling pathway and inhibition of NF-kappaB via its specific antagonist, pyrrolidine dithiocarbamate, indicated that NF-kappaB was involved in the CCR7-mediated apoptosis.	pyrrolidine dithiocarbamic acid	125-152	nuclear factor kappa B subunit 1	Homo sapiens	86-95
28339080-6	2017	In addition, CCR7-siRNA inactivated the NF-kappaB signaling pathway and inhibition of NF-kappaB via its specific antagonist, pyrrolidine dithiocarbamate, indicated that NF-kappaB was involved in the CCR7-mediated apoptosis.	pyrrolidine dithiocarbamic acid	125-152	nuclear factor kappa B subunit 1	Homo sapiens	86-95
28339080-6	2017	In addition, CCR7-siRNA inactivated the NF-kappaB signaling pathway and inhibition of NF-kappaB via its specific antagonist, pyrrolidine dithiocarbamate, indicated that NF-kappaB was involved in the CCR7-mediated apoptosis.	pyrrolidine dithiocarbamic acid	125-152	C-C motif chemokine receptor 7	Homo sapiens	199-203
28339078-4	2017	Pyrrolidine dithiocarbamate (PDTC; 50 microM) was used to inhibit the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	84-93
26797516-6	2017	Pharmacological inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC; 50 muM) or quinazoline (QNZ; 10 muM) also abolished TGF-alpha promoter activity, and NF-kappaB directly bound to its consensus site in the TGF-alpha promoter as evidenced by electrophoretic mobility shift assay (EMSA).	pyrrolidine dithiocarbamic acid	45-72	transforming growth factor alpha	Homo sapiens	219-228
26797516-6	2017	Pharmacological inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC; 50 muM) or quinazoline (QNZ; 10 muM) also abolished TGF-alpha promoter activity, and NF-kappaB directly bound to its consensus site in the TGF-alpha promoter as evidenced by electrophoretic mobility shift assay (EMSA).	pyrrolidine dithiocarbamic acid	74-78	transforming growth factor alpha	Homo sapiens	132-141
26797516-6	2017	Pharmacological inhibition of NF-kappaB with pyrrolidine dithiocarbamate (PDTC; 50 muM) or quinazoline (QNZ; 10 muM) also abolished TGF-alpha promoter activity, and NF-kappaB directly bound to its consensus site in the TGF-alpha promoter as evidenced by electrophoretic mobility shift assay (EMSA).	pyrrolidine dithiocarbamic acid	74-78	transforming growth factor alpha	Homo sapiens	219-228
27927986-10	2017	The NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited LPS-induced iNOS expression under high glucose conditions but it did not influence iNOS induction under normal glucose conditions.	pyrrolidine dithiocarbamic acid	25-52	nitric oxide synthase 2	Homo sapiens	76-80
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	165-192	interleukin 17A	Homo sapiens	14-20
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	165-192	matrix metallopeptidase 2	Homo sapiens	43-50
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	165-192	X-linked Kx blood group	Homo sapiens	140-143
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	194-198	interleukin 17A	Homo sapiens	14-20
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	194-198	matrix metallopeptidase 2	Homo sapiens	43-50
28184939-11	2017	Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	194-198	X-linked Kx blood group	Homo sapiens	140-143
27927986-11	2017	In addition, pyrrolidine dithiocarbamate inhibited NF-kappaB DNA binding and c-Rel O-GlcNAcylation only under high glucose conditions.	pyrrolidine dithiocarbamic acid	13-40	REL proto-oncogene, NF-kB subunit	Homo sapiens	77-82
27959400-10	2017	Pretreatment of the in vitro resistin-treated AP model with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate decreased the protein expression of the NF-kappaB p65 subunit in nuclei, and significantly attenuated the increased mRNA expression levels of TNF-alpha and IL-6 induced by resistin.	pyrrolidine dithiocarbamic acid	85-112	resistin	Rattus norvegicus	29-37
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	56-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-25
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	56-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-41
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	56-83	CD40 molecule	Homo sapiens	111-115
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	85-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-25
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	85-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-41
27916733-10	2017	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) reduced LPS-induced CD40 expression in IMCD cells.	pyrrolidine dithiocarbamic acid	85-89	CD40 molecule	Homo sapiens	111-115
27932245-5	2017	Mechanistic analyses further revealed that IL-1beta-induced activation of the NF-kappaB pathway is suppressed upon TREM-1 knockdown, similar to the effect of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	158-185	interleukin 1 beta	Mus musculus	43-51
27932245-5	2017	Mechanistic analyses further revealed that IL-1beta-induced activation of the NF-kappaB pathway is suppressed upon TREM-1 knockdown, similar to the effect of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	158-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-87
27932245-5	2017	Mechanistic analyses further revealed that IL-1beta-induced activation of the NF-kappaB pathway is suppressed upon TREM-1 knockdown, similar to the effect of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	158-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
28098169-7	2017	DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) or SB203580 (a MAPK inhibitor) showed significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro.	pyrrolidine dithiocarbamic acid	51-78	interferon gamma	Homo sapiens	19-28
28098169-7	2017	DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) or SB203580 (a MAPK inhibitor) showed significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro.	pyrrolidine dithiocarbamic acid	80-84	interferon gamma	Homo sapiens	19-28
28719912-11	2017	Moreover, pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, pyrrolidine dithio carbamate, augmented the protective effects of crocin.	pyrrolidine dithiocarbamic acid	10-37	nuclear factor kappa B subunit 1	Homo sapiens	41-50
28719912-11	2017	Moreover, pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, pyrrolidine dithio carbamate, augmented the protective effects of crocin.	pyrrolidine dithiocarbamic acid	62-90	nuclear factor kappa B subunit 1	Homo sapiens	41-50
28849713-5	2017	Importantly, the upregulated CX3CL1 is mediated by the NF-kappaB signaling pathway, as inhibition of NF-kappaB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin.	pyrrolidine dithiocarbamic acid	131-158	C-X3-C motif chemokine ligand 1	Homo sapiens	29-35
28849713-5	2017	Importantly, the upregulated CX3CL1 is mediated by the NF-kappaB signaling pathway, as inhibition of NF-kappaB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin.	pyrrolidine dithiocarbamic acid	131-158	nuclear factor kappa B subunit 1	Homo sapiens	55-64
28849713-5	2017	Importantly, the upregulated CX3CL1 is mediated by the NF-kappaB signaling pathway, as inhibition of NF-kappaB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin.	pyrrolidine dithiocarbamic acid	131-158	nuclear factor kappa B subunit 1	Homo sapiens	101-110
28849713-5	2017	Importantly, the upregulated CX3CL1 is mediated by the NF-kappaB signaling pathway, as inhibition of NF-kappaB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin.	pyrrolidine dithiocarbamic acid	131-158	RELA proto-oncogene, NF-kB subunit	Homo sapiens	111-114
28849713-5	2017	Importantly, the upregulated CX3CL1 is mediated by the NF-kappaB signaling pathway, as inhibition of NF-kappaB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin.	pyrrolidine dithiocarbamic acid	131-158	C-X3-C motif chemokine ligand 1	Homo sapiens	202-208
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-25
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-41
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-83	aquaporin 2	Homo sapiens	100-104
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	56-83	tumor necrosis factor	Homo sapiens	141-150
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	85-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-25
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	85-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-41
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	85-89	aquaporin 2	Homo sapiens	100-104
27980322-10	2016	Knockdown of NF-kappaBp65 or NF-kappaBp65 inhibition by pyrrolidine dithiocarbamate (PDTC) enhanced AQP2 expression in IMCD cells exposed to TNF-alpha.	pyrrolidine dithiocarbamic acid	85-89	tumor necrosis factor	Homo sapiens	141-150
27868128-6	2016	By utilizing the ERK inhibitor U0126 and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that STIM1 can be regulated by ERK and NF-kappaB.	pyrrolidine dithiocarbamic acid	65-92	stromal interaction molecule 1	Homo sapiens	119-124
27868128-6	2016	By utilizing the ERK inhibitor U0126 and the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), we confirmed that STIM1 can be regulated by ERK and NF-kappaB.	pyrrolidine dithiocarbamic acid	65-92	mitogen-activated protein kinase 1	Homo sapiens	145-148
27916082-0	2016	[Effects of ammonium pyrrolidine dithiocarbamate (PDTC) on osteopontin expression and autophagy in tubular cells in streptozotocin-induced diabetic nephropathy rat].	pyrrolidine dithiocarbamic acid	12-48	secreted phosphoprotein 1	Rattus norvegicus	59-70
27916082-0	2016	[Effects of ammonium pyrrolidine dithiocarbamate (PDTC) on osteopontin expression and autophagy in tubular cells in streptozotocin-induced diabetic nephropathy rat].	pyrrolidine dithiocarbamic acid	50-54	secreted phosphoprotein 1	Rattus norvegicus	59-70
29227975-10	2017	In contrast, VSMC calcification and the increased expression of inflammatory cytokines were markedly attenuated by pretreatment with TLR4 siRNA and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	148-179	nuclear factor kappa B subunit 1	Homo sapiens	184-193
27959400-10	2017	Pretreatment of the in vitro resistin-treated AP model with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate decreased the protein expression of the NF-kappaB p65 subunit in nuclei, and significantly attenuated the increased mRNA expression levels of TNF-alpha and IL-6 induced by resistin.	pyrrolidine dithiocarbamic acid	85-112	tumor necrosis factor	Rattus norvegicus	255-264
27959400-10	2017	Pretreatment of the in vitro resistin-treated AP model with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate decreased the protein expression of the NF-kappaB p65 subunit in nuclei, and significantly attenuated the increased mRNA expression levels of TNF-alpha and IL-6 induced by resistin.	pyrrolidine dithiocarbamic acid	85-112	interleukin 6	Rattus norvegicus	269-273
27959400-10	2017	Pretreatment of the in vitro resistin-treated AP model with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate decreased the protein expression of the NF-kappaB p65 subunit in nuclei, and significantly attenuated the increased mRNA expression levels of TNF-alpha and IL-6 induced by resistin.	pyrrolidine dithiocarbamic acid	85-112	resistin	Rattus norvegicus	285-293
26860689-0	2016	Pyrrolidine dithiocarbamate attenuates paraquat-induced acute pulmonary poisoning in vivo via transforming growth factor beta1 and nuclear factor kappaB pathway interaction.	pyrrolidine dithiocarbamic acid	0-27	transforming growth factor, beta 1	Rattus norvegicus	94-126
27748925-5	2016	The effects of AngII were abrogated by sodium hydrosulfide (NaHS, an H2S donor), BQ788 or pyrrolidinedithiocarbamic acid (PDTC, an inhibitor of NF-kappaB).	pyrrolidine dithiocarbamic acid	90-120	angiotensinogen	Homo sapiens	15-20
27748925-5	2016	The effects of AngII were abrogated by sodium hydrosulfide (NaHS, an H2S donor), BQ788 or pyrrolidinedithiocarbamic acid (PDTC, an inhibitor of NF-kappaB).	pyrrolidine dithiocarbamic acid	122-126	angiotensinogen	Homo sapiens	15-20
27280587-10	2016	Additionally, exogenous PLGF-induced activation of MMPs in rat RLE-6TN alveolar epithelial cells was suppressed by NFkappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	134-161	matrix metallopeptidase 2	Rattus norvegicus	51-55
27602092-9	2016	In addition, the expression level of p-NF-kappaB and the production of chemokines in lung tissue decreased in ARDS mice that were treated with PDTC, and the number of PMNs in BALF also decreased.	pyrrolidine dithiocarbamic acid	143-147	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48
27280587-10	2016	Additionally, exogenous PLGF-induced activation of MMPs in rat RLE-6TN alveolar epithelial cells was suppressed by NFkappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	134-161	placental growth factor	Rattus norvegicus	24-28
27180929-10	2016	The originally increased transforming growth factor-beta and angiotensinogen levels as a result of lipopolysaccharide stimulation were reduced at both the messenger RNA and protein levels after the specific inhibition of the nuclear factor-kappaB pathway with pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	260-287	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	61-76
26715508-12	2016	Pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappa B (NF-kappaB) inhibitor, significantly reduced hypoxia induced TF expression, and HIF-1alpha knockdown further increased TF.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	38-60
26715508-12	2016	Pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappa B (NF-kappaB) inhibitor, significantly reduced hypoxia induced TF expression, and HIF-1alpha knockdown further increased TF.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	62-71
26715508-12	2016	Pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappa B (NF-kappaB) inhibitor, significantly reduced hypoxia induced TF expression, and HIF-1alpha knockdown further increased TF.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	38-60
26715508-12	2016	Pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappa B (NF-kappaB) inhibitor, significantly reduced hypoxia induced TF expression, and HIF-1alpha knockdown further increased TF.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	62-71
27241100-8	2016	Inhibition of NF-kappaB activation with the specific NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate), reversed Bcl-xL down-regulation and Bax up-regulation, and led to a significant increase in LIGHT- and IFN-gamma-treated cell viability.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
27241100-8	2016	Inhibition of NF-kappaB activation with the specific NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate), reversed Bcl-xL down-regulation and Bax up-regulation, and led to a significant increase in LIGHT- and IFN-gamma-treated cell viability.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
27241100-8	2016	Inhibition of NF-kappaB activation with the specific NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate), reversed Bcl-xL down-regulation and Bax up-regulation, and led to a significant increase in LIGHT- and IFN-gamma-treated cell viability.	pyrrolidine dithiocarbamic acid	80-107	BCL2-like 1	Mus musculus	119-125
27241100-8	2016	Inhibition of NF-kappaB activation with the specific NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate), reversed Bcl-xL down-regulation and Bax up-regulation, and led to a significant increase in LIGHT- and IFN-gamma-treated cell viability.	pyrrolidine dithiocarbamic acid	80-107	BCL2-associated X protein	Mus musculus	146-149
27241100-8	2016	Inhibition of NF-kappaB activation with the specific NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate), reversed Bcl-xL down-regulation and Bax up-regulation, and led to a significant increase in LIGHT- and IFN-gamma-treated cell viability.	pyrrolidine dithiocarbamic acid	80-107	interferon gamma	Mus musculus	213-222
27575706-4	2016	MAIN METHODS: In this regard Pepinh- TRIF, Pepinh- MYD and pyrrolidine dithiocarbamate (PDTC) were used to inhibit TRIF, MYD88 and NF-kB pathways.	pyrrolidine dithiocarbamic acid	59-86	TIR domain containing adaptor molecule 1	Homo sapiens	115-119
27575706-4	2016	MAIN METHODS: In this regard Pepinh- TRIF, Pepinh- MYD and pyrrolidine dithiocarbamate (PDTC) were used to inhibit TRIF, MYD88 and NF-kB pathways.	pyrrolidine dithiocarbamic acid	88-92	TIR domain containing adaptor molecule 1	Homo sapiens	115-119
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	0-27	signal transducer and activator of transcription 3	Mus musculus	125-130
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	29-33	signal transducer and activator of transcription 3	Mus musculus	125-130
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
27391329-3	2016	Inhibition of NF-kappaB with pyrrolidine dithiocarbamate and small interfering RNA decreased the expression of ET-1.	pyrrolidine dithiocarbamic acid	29-56	endothelin-1	Oryctolagus cuniculus	111-115
27315281-9	2016	The combination treatment of PDTC and SP600125, a JNK pathway inhibitor, increased the survival of Cd-stimulated HRGECs compared with those cells treated with PDTC alone (p&lt;0.05).	pyrrolidine dithiocarbamic acid	29-33	mitogen-activated protein kinase 8	Homo sapiens	50-53
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	0-27	toll-like receptor 4	Mus musculus	100-103
27177083-6	2016	In addition, FA enhanced the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) in RAW 264.7 cells; the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC) effectively attenuated the expression of FA-stimulated iNOS, suggesting that FA stimulates NF-kappaB to promote iNOS and NO production.	pyrrolidine dithiocarbamic acid	132-159	nitric oxide synthase 2, inducible	Mus musculus	222-226
27177083-6	2016	In addition, FA enhanced the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) in RAW 264.7 cells; the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC) effectively attenuated the expression of FA-stimulated iNOS, suggesting that FA stimulates NF-kappaB to promote iNOS and NO production.	pyrrolidine dithiocarbamic acid	132-159	nitric oxide synthase 2, inducible	Mus musculus	279-283
27177083-6	2016	In addition, FA enhanced the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) in RAW 264.7 cells; the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC) effectively attenuated the expression of FA-stimulated iNOS, suggesting that FA stimulates NF-kappaB to promote iNOS and NO production.	pyrrolidine dithiocarbamic acid	161-165	nitric oxide synthase 2, inducible	Mus musculus	222-226
27177083-6	2016	In addition, FA enhanced the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) in RAW 264.7 cells; the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC) effectively attenuated the expression of FA-stimulated iNOS, suggesting that FA stimulates NF-kappaB to promote iNOS and NO production.	pyrrolidine dithiocarbamic acid	161-165	nitric oxide synthase 2, inducible	Mus musculus	279-283
26933138-12	2016	Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues.	pyrrolidine dithiocarbamic acid	130-157	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	49-61
26933138-12	2016	Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues.	pyrrolidine dithiocarbamic acid	130-157	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	66-69
26933138-12	2016	Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues.	pyrrolidine dithiocarbamic acid	130-157	interleukin 17A	Mus musculus	173-178
26933138-12	2016	Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues.	pyrrolidine dithiocarbamic acid	130-157	claudin 4	Mus musculus	205-214
26933138-12	2016	Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues.	pyrrolidine dithiocarbamic acid	130-157	tight junction protein 1	Mus musculus	219-223
27565904-4	2016	The effect of systemic administration of a NF-kappaB inhibitor, pyrrolidinedithiocarbamate (PDTC), on renal I/R injury was also examined.	pyrrolidine dithiocarbamic acid	64-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	52-79	tumor necrosis factor	Rattus norvegicus	164-197
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	52-79	interleukin 1 beta	Rattus norvegicus	202-219
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	52-79	interleukin 1 beta	Rattus norvegicus	221-229
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	81-85	tumor necrosis factor	Rattus norvegicus	164-197
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	81-85	interleukin 1 beta	Rattus norvegicus	202-219
27493629-5	2016	Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats.	pyrrolidine dithiocarbamic acid	81-85	interleukin 1 beta	Rattus norvegicus	221-229
27282980-10	2016	So far, peroxisome proliferator activator receptor gamma (PPAR-gamma) ligand, pyrrolidine dithiocarbamate (PDTC), proteasome inhibitor and calpain I inhibitor have been shown to have direct inhibitory effects on NF-kappaB activation in experimental AP.	pyrrolidine dithiocarbamic acid	78-105	nuclear factor kappa B subunit 1	Homo sapiens	212-221
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2, inducible	Mus musculus	112-116
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	0-27	prostaglandin-endoperoxide synthase 2	Mus musculus	121-126
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2, inducible	Mus musculus	248-252
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	0-27	prostaglandin-endoperoxide synthase 2	Mus musculus	257-262
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	29-33	toll-like receptor 4	Mus musculus	100-103
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2, inducible	Mus musculus	112-116
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	29-33	prostaglandin-endoperoxide synthase 2	Mus musculus	121-126
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	29-33	nitric oxide synthase 2, inducible	Mus musculus	248-252
27131287-7	2016	Pyrrolidine dithiocarbamate (PDTC), a specific NF-kappaB inhibitor, downregulated the expression of LPS-induced iNOS and COX-2, which suggests that morin-mediated NF-kappaB inhibition is the main signaling pathway responsible for the inhibition of iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	29-33	prostaglandin-endoperoxide synthase 2	Mus musculus	257-262
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	85-112	nuclear factor kappa B subunit 1	Homo sapiens	24-33
27032067-5	2016	Additionally, the NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and PS-1145, significantly attenuated LPS-induced iNOS expression, indicating that hydrangenol-induced NF-kappaB inhibition might be a key regulator of iNOS expression.	pyrrolidine dithiocarbamic acid	40-67	nitric oxide synthase 2, inducible	Mus musculus	125-129
27032067-5	2016	Additionally, the NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and PS-1145, significantly attenuated LPS-induced iNOS expression, indicating that hydrangenol-induced NF-kappaB inhibition might be a key regulator of iNOS expression.	pyrrolidine dithiocarbamic acid	40-67	nitric oxide synthase 2, inducible	Mus musculus	227-231
27032067-5	2016	Additionally, the NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and PS-1145, significantly attenuated LPS-induced iNOS expression, indicating that hydrangenol-induced NF-kappaB inhibition might be a key regulator of iNOS expression.	pyrrolidine dithiocarbamic acid	69-73	nitric oxide synthase 2, inducible	Mus musculus	125-129
27032067-5	2016	Additionally, the NF-kappaB inhibitors, pyrrolidine dithiocarbamate (PDTC) and PS-1145, significantly attenuated LPS-induced iNOS expression, indicating that hydrangenol-induced NF-kappaB inhibition might be a key regulator of iNOS expression.	pyrrolidine dithiocarbamic acid	69-73	nitric oxide synthase 2, inducible	Mus musculus	227-231
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	73-108	nuclear factor kappa B subunit 1	Homo sapiens	53-62
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	73-108	matrix metallopeptidase 9	Homo sapiens	176-181
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	110-114	nuclear factor kappa B subunit 1	Homo sapiens	53-62
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	pyrrolidine dithiocarbamic acid	110-114	matrix metallopeptidase 9	Homo sapiens	176-181
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	latexin	Homo sapiens	86-89
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	matrix metallopeptidase 9	Homo sapiens	209-214
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	cadherin 1	Homo sapiens	216-226
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	toll like receptor 4	Homo sapiens	228-232
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	nuclear factor kappa B subunit 1	Homo sapiens	238-247
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	pyrrolidine dithiocarbamic acid	49-76	RELA proto-oncogene, NF-kB subunit	Homo sapiens	248-251
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	85-112	nuclear factor kappa B subunit 1	Homo sapiens	74-83
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	85-112	mitogen-activated protein kinase 8	Homo sapiens	136-139
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	114-118	nuclear factor kappa B subunit 1	Homo sapiens	24-33
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	114-118	nuclear factor kappa B subunit 1	Homo sapiens	74-83
27016483-4	2016	Moreover, inhibition of NF-kappaB by FSH or another specific inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), could activate JNK signaling and enhance autophagic activity in porcine granulosa cells.	pyrrolidine dithiocarbamic acid	114-118	mitogen-activated protein kinase 8	Homo sapiens	136-139
26130066-4	2016	The NF-kappaB inhibitors pyrrolidine dithiocarbamate (PDTC) and sulfasalazine decreased spontaneous contractile activity and reduced myotube viability in a dose- and time-dependent manner.	pyrrolidine dithiocarbamic acid	25-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	4-13
26922321-8	2016	A similar effect was produced by treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	72-99	nuclear factor kappa B subunit 1	Homo sapiens	52-61
26130066-4	2016	The NF-kappaB inhibitors pyrrolidine dithiocarbamate (PDTC) and sulfasalazine decreased spontaneous contractile activity and reduced myotube viability in a dose- and time-dependent manner.	pyrrolidine dithiocarbamic acid	54-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	4-13
27594770-9	2016	Exposure to ox-LDL induced upregulation of ALOX15 in HUVECs, but this effect was partially abolished by atorvastatin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	144-171	arachidonate 15-lipoxygenase	Homo sapiens	43-49
26213293-10	2016	Treatment with the potent anti-oxidant pyrrolidine dithiocarbamate (PDTC) significantly suppressed NTT-MMP-2, but not FL-MMP-2 expression and improved muscle viability following IRI.	pyrrolidine dithiocarbamic acid	39-66	matrix metallopeptidase 2	Mus musculus	103-108
26213293-10	2016	Treatment with the potent anti-oxidant pyrrolidine dithiocarbamate (PDTC) significantly suppressed NTT-MMP-2, but not FL-MMP-2 expression and improved muscle viability following IRI.	pyrrolidine dithiocarbamic acid	39-66	matrix metallopeptidase 2	Mus musculus	118-126
26213293-10	2016	Treatment with the potent anti-oxidant pyrrolidine dithiocarbamate (PDTC) significantly suppressed NTT-MMP-2, but not FL-MMP-2 expression and improved muscle viability following IRI.	pyrrolidine dithiocarbamic acid	68-72	matrix metallopeptidase 2	Mus musculus	103-108
26213293-10	2016	Treatment with the potent anti-oxidant pyrrolidine dithiocarbamate (PDTC) significantly suppressed NTT-MMP-2, but not FL-MMP-2 expression and improved muscle viability following IRI.	pyrrolidine dithiocarbamic acid	68-72	matrix metallopeptidase 2	Mus musculus	118-126
26551397-6	2016	Most importantly, kindlin-2-induced invasiveness was almost completely abolished by pretreatment with pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB signaling) or co-transfection with MMP-9 or MMP-2 siRNA.	pyrrolidine dithiocarbamic acid	102-129	FERM domain containing kindlin 2	Homo sapiens	18-27
26551397-6	2016	Most importantly, kindlin-2-induced invasiveness was almost completely abolished by pretreatment with pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB signaling) or co-transfection with MMP-9 or MMP-2 siRNA.	pyrrolidine dithiocarbamic acid	102-129	nuclear factor kappa B subunit 1	Homo sapiens	147-156
26655640-5	2015	Suppression of cellular MyD88 by ST2825 or abrogation of NF-kappaB by pyrrolidine dithiocarbamate eliminated the inhibitory effects of dioscin on the levels of TGF-beta1, alpha-SMA and COL1A1.	pyrrolidine dithiocarbamic acid	70-97	nuclear factor kappa B subunit 1	Homo sapiens	57-66
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	pyrrolidine dithiocarbamic acid	0-27	glutathione peroxidase 1	Homo sapiens	92-96
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	pyrrolidine dithiocarbamic acid	0-27	glutathione peroxidase 4	Homo sapiens	98-102
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	pyrrolidine dithiocarbamic acid	0-27	occludin	Homo sapiens	104-112
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	pyrrolidine dithiocarbamic acid	0-27	tight junction protein 1	Homo sapiens	118-122
26934326-5	2016	Inactivation of NF-kappaB by pyrrolidine dithiocarbamic acid (PDTC) significantly blocked the effect of miR-155-5p inhibitor on BM-MSC.	pyrrolidine dithiocarbamic acid	29-60	microRNA 155	Homo sapiens	104-111
26934326-5	2016	Inactivation of NF-kappaB by pyrrolidine dithiocarbamic acid (PDTC) significantly blocked the effect of miR-155-5p inhibitor on BM-MSC.	pyrrolidine dithiocarbamic acid	62-66	microRNA 155	Homo sapiens	104-111
26852662-7	2016	Pretreatment of macrophages with a radical scavenger(pyrrolidinedithiocarbamate) also limited the decrease of TF in whole-cell lysates after stimulation with SP.	pyrrolidine dithiocarbamic acid	53-79	coagulation factor III, tissue factor	Homo sapiens	110-112
26920699-0	2016	Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
26920699-5	2016	METHODS: Here, we investigate Nrf2 induction by the metal chelator and known nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) in cultured astrocytes and neurons, and mouse brain.	pyrrolidine dithiocarbamic acid	109-136	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
26920699-5	2016	METHODS: Here, we investigate Nrf2 induction by the metal chelator and known nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) in cultured astrocytes and neurons, and mouse brain.	pyrrolidine dithiocarbamic acid	138-142	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	87-114	nuclear factor kappa B subunit 1	Homo sapiens	50-76
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	87-114	tumor necrosis factor	Homo sapiens	176-185
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	87-114	CD40 molecule	Homo sapiens	213-217
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	116-120	nuclear factor kappa B subunit 1	Homo sapiens	50-76
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	116-120	tumor necrosis factor	Homo sapiens	176-185
26799794-7	2016	Moreover, the p38 MAPK inhibitor SD203580 and the nuclear factor (NF)-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as resveratrol on TNF-alpha-induced ROS generation and CD40 expression.	pyrrolidine dithiocarbamic acid	116-120	CD40 molecule	Homo sapiens	213-217
25958302-4	2016	Treating FHH dams with pyrrolidine di thio carbamate (PDTC), an NFkappaB inhibitor, from 2 weeks before birth to 4 weeks after birth diminished NFkB activity in 2-day-FHH offspring to 2-day-WKY levels (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	23-52	nuclear factor kappa B subunit 1	Rattus norvegicus	144-148
25958302-4	2016	Treating FHH dams with pyrrolidine di thio carbamate (PDTC), an NFkappaB inhibitor, from 2 weeks before birth to 4 weeks after birth diminished NFkB activity in 2-day-FHH offspring to 2-day-WKY levels (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	54-58	nuclear factor kappa B subunit 1	Rattus norvegicus	144-148
26767865-4	2016	MCP-1 levels in HK-2 cell-conditioned media were measured after pre-treatment with the transcription factor inhibitors curcumin or pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	131-158	chemokine (C-C motif) ligand 2	Mus musculus	0-5
27594770-9	2016	Exposure to ox-LDL induced upregulation of ALOX15 in HUVECs, but this effect was partially abolished by atorvastatin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	144-171	nuclear factor kappa B subunit 1	Homo sapiens	124-133
27594770-9	2016	Exposure to ox-LDL induced upregulation of ALOX15 in HUVECs, but this effect was partially abolished by atorvastatin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	173-177	arachidonate 15-lipoxygenase	Homo sapiens	43-49
27594770-9	2016	Exposure to ox-LDL induced upregulation of ALOX15 in HUVECs, but this effect was partially abolished by atorvastatin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	173-177	nuclear factor kappa B subunit 1	Homo sapiens	124-133
26130762-7	2015	The inhibition of p65 signaling using the NF-kappaB inhibitor pyrrolidine dithiocarbamate or recombinant lentiviral vectors designated as lentiviral vector-p65 small interfering RNA remarkably suppressed P2X3R activities and attenuated diabetic pain hypersensitivity.	pyrrolidine dithiocarbamic acid	62-89	synaptotagmin 1	Rattus norvegicus	18-21
26622531-6	2015	p65 was identified to be a primary component of NF-kappaB, since it was upregulated in the miR-181b overexpression in the BEAS-2B cells, while pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB, was found to be able to abrogate the upregulation of the expression of p65.	pyrrolidine dithiocarbamic acid	143-170	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-3
32262864-2	2015	Pyrrolidinedithiocarbamate (PDTC), a nuclear-factor-kappa B (NF-kappaB) inhibitor, was demonstrated to be able to overcome chemoresistance and enhance doxorubicin (DOX) efficacy as a chemotherapeutic sensitizer.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	37-59
32262864-2	2015	Pyrrolidinedithiocarbamate (PDTC), a nuclear-factor-kappa B (NF-kappaB) inhibitor, was demonstrated to be able to overcome chemoresistance and enhance doxorubicin (DOX) efficacy as a chemotherapeutic sensitizer.	pyrrolidine dithiocarbamic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	61-70
32262864-2	2015	Pyrrolidinedithiocarbamate (PDTC), a nuclear-factor-kappa B (NF-kappaB) inhibitor, was demonstrated to be able to overcome chemoresistance and enhance doxorubicin (DOX) efficacy as a chemotherapeutic sensitizer.	pyrrolidine dithiocarbamic acid	28-32	nuclear factor kappa B subunit 1	Homo sapiens	37-59
32262864-2	2015	Pyrrolidinedithiocarbamate (PDTC), a nuclear-factor-kappa B (NF-kappaB) inhibitor, was demonstrated to be able to overcome chemoresistance and enhance doxorubicin (DOX) efficacy as a chemotherapeutic sensitizer.	pyrrolidine dithiocarbamic acid	28-32	nuclear factor kappa B subunit 1	Homo sapiens	61-70
26492242-8	2015	Pretreatment with a specific inhibitor of NF-kappaB (pyrrolidinedithiocarbamate, PDTC) strikingly abrogated miR-223 silence-induced lipid deposition and inflammatory cytokine production.	pyrrolidine dithiocarbamic acid	53-79	microRNA 223	Mus musculus	108-115
25816715-0	2015	The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension.	pyrrolidine dithiocarbamic acid	36-63	matrix metallopeptidase 2	Rattus norvegicus	97-123
26622531-6	2015	p65 was identified to be a primary component of NF-kappaB, since it was upregulated in the miR-181b overexpression in the BEAS-2B cells, while pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB, was found to be able to abrogate the upregulation of the expression of p65.	pyrrolidine dithiocarbamic acid	143-170	nuclear factor kappa B subunit 1	Homo sapiens	48-57
26622531-6	2015	p65 was identified to be a primary component of NF-kappaB, since it was upregulated in the miR-181b overexpression in the BEAS-2B cells, while pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB, was found to be able to abrogate the upregulation of the expression of p65.	pyrrolidine dithiocarbamic acid	143-170	nuclear factor kappa B subunit 1	Homo sapiens	196-205
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	35-62	NLR family CARD domain containing 5	Homo sapiens	138-143
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	35-62	NLR family CARD domain containing 5	Homo sapiens	159-164
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	35-62	RELA proto-oncogene, NF-kB subunit	Homo sapiens	215-218
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	35-62	SMAD family member 3	Homo sapiens	283-288
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	35-62	tumor necrosis factor	Homo sapiens	319-328
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	64-68	NLR family CARD domain containing 5	Homo sapiens	138-143
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	64-68	NLR family CARD domain containing 5	Homo sapiens	159-164
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	64-68	RELA proto-oncogene, NF-kB subunit	Homo sapiens	215-218
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	64-68	SMAD family member 3	Homo sapiens	283-288
25820389-7	2015	Meanwhile, the results showed that pyrrolidine dithiocarbamate (PDTC) (a specific inhibitor of the NF-kappaB signaling pathway) inhibited NLRC5 expression and NLRC5 silencing could increase the expression levels of p65 in cell nucleus accompanied with upregulated phosphorylation of Smad3 protein levels in response to TNF-alpha.	pyrrolidine dithiocarbamic acid	64-68	tumor necrosis factor	Homo sapiens	319-328
26049406-5	2015	Inhibition of NF-kappaB signaling using p65 inhibitor pyrrolidine dithiocarbamate, BAY-11-7082, or lentiviral-p65 short-hairpin RNA significantly attenuated CIP and reversed the activities of P2X3R.	pyrrolidine dithiocarbamic acid	54-81	synaptotagmin 1	Rattus norvegicus	40-43
26009993-7	2015	Treatment of 5TGM1 tumor-bearing mice with a beta-TrCP1/FWD1 inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly reduced tumor burden in bone.	pyrrolidine dithiocarbamic acid	72-99	beta-transducin repeat containing protein	Mus musculus	45-55
26372842-12	2015	Pyrrolidine dithiocarbamate or SB203580 inhibited NF-kappaB activation and p38 phosphorylation; thus, SEC or SMC pretreatments failed to affect protein expression of these factors.	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 14	Homo sapiens	75-78
24677730-4	2015	Exposure to NP stimulated activation of NF-kappaB, whereas the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, attenuated NP-enhanced COX-2 expression and IL-6 and PGE2 release in TM4 cells in a dose-dependent manner.	pyrrolidine dithiocarbamic acid	84-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
24677730-4	2015	Exposure to NP stimulated activation of NF-kappaB, whereas the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, attenuated NP-enhanced COX-2 expression and IL-6 and PGE2 release in TM4 cells in a dose-dependent manner.	pyrrolidine dithiocarbamic acid	84-111	cytochrome c oxidase II, mitochondrial	Mus musculus	136-141
24677730-4	2015	Exposure to NP stimulated activation of NF-kappaB, whereas the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, attenuated NP-enhanced COX-2 expression and IL-6 and PGE2 release in TM4 cells in a dose-dependent manner.	pyrrolidine dithiocarbamic acid	84-111	interleukin 6	Mus musculus	157-161
26009993-7	2015	Treatment of 5TGM1 tumor-bearing mice with a beta-TrCP1/FWD1 inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly reduced tumor burden in bone.	pyrrolidine dithiocarbamic acid	72-99	beta-transducin repeat containing protein	Mus musculus	56-60
26009993-7	2015	Treatment of 5TGM1 tumor-bearing mice with a beta-TrCP1/FWD1 inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly reduced tumor burden in bone.	pyrrolidine dithiocarbamic acid	101-105	beta-transducin repeat containing protein	Mus musculus	45-55
26009993-7	2015	Treatment of 5TGM1 tumor-bearing mice with a beta-TrCP1/FWD1 inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly reduced tumor burden in bone.	pyrrolidine dithiocarbamic acid	101-105	beta-transducin repeat containing protein	Mus musculus	56-60
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	pyrrolidine dithiocarbamic acid	36-63	mucin 4, cell surface associated	Homo sapiens	124-128
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	pyrrolidine dithiocarbamic acid	36-63	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	133-138
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	pyrrolidine dithiocarbamic acid	65-69	mucin 4, cell surface associated	Homo sapiens	124-128
26010124-7	2015	SB203580 (a p38 MAPK inhibitor) and pyrrolidine dithiocarbamate (PDTC; a NF-kappaB inhibitor) inhibited beta-glucan-induced MUC4 and MUC5B expression.	pyrrolidine dithiocarbamic acid	65-69	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	133-138
25480733-9	2015	Transfection of NF-kappaB (p65 subunit) intensely induced the promoter activity of the porcine S100A6 gene, while an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), inhibited this activity.	pyrrolidine dithiocarbamic acid	138-165	nuclear factor kappa B subunit 1	Homo sapiens	16-25
25480733-9	2015	Transfection of NF-kappaB (p65 subunit) intensely induced the promoter activity of the porcine S100A6 gene, while an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), inhibited this activity.	pyrrolidine dithiocarbamic acid	138-165	nuclear factor kappa B subunit 1	Homo sapiens	117-126
25480733-9	2015	Transfection of NF-kappaB (p65 subunit) intensely induced the promoter activity of the porcine S100A6 gene, while an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), inhibited this activity.	pyrrolidine dithiocarbamic acid	167-171	nuclear factor kappa B subunit 1	Homo sapiens	16-25
26427115-9	2015	An NF-kappaB inhibitor, pyrrolidine dithiocarbamate, enhanced the inhibitory effect of Rg3 on SW480 cell migration.	pyrrolidine dithiocarbamic acid	24-51	nuclear factor kappa B subunit 1	Homo sapiens	3-12
26229403-9	2015	Furthermore, the NF-kappaB-selective inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the upregulation of CBS (1.0 +- 0.1 vs 0.6 +- 0.1, P &lt; 0.05) and attenuated visceral hypersensitivity in the NCI rats.	pyrrolidine dithiocarbamic acid	47-74	cystathionine beta synthase	Rattus norvegicus	124-127
26380524-8	2015	Pretreatment with pyrrolidine dithiocarbamate (an exogenous inhibitor of NF-KB) decreased RSNA, MAP and HR, and abolished the effects of salusin-beta in the PVN in the OH rats.	pyrrolidine dithiocarbamic acid	18-45	nuclear factor kappa B subunit 1	Rattus norvegicus	73-78
26229403-9	2015	Furthermore, the NF-kappaB-selective inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced the upregulation of CBS (1.0 +- 0.1 vs 0.6 +- 0.1, P &lt; 0.05) and attenuated visceral hypersensitivity in the NCI rats.	pyrrolidine dithiocarbamic acid	76-80	cystathionine beta synthase	Rattus norvegicus	124-127
25811965-7	2015	We also found that baicalein reduced the activation of NF-kappaB signaling molecules; in addition, the MMP-2 expression and invasion ability of ovarian cancer cells were abolished with the treatment of the NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	227-254	nuclear factor kappa B subunit 1	Homo sapiens	55-64
25811965-7	2015	We also found that baicalein reduced the activation of NF-kappaB signaling molecules; in addition, the MMP-2 expression and invasion ability of ovarian cancer cells were abolished with the treatment of the NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	227-254	matrix metallopeptidase 2	Homo sapiens	103-108
25811965-7	2015	We also found that baicalein reduced the activation of NF-kappaB signaling molecules; in addition, the MMP-2 expression and invasion ability of ovarian cancer cells were abolished with the treatment of the NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	227-254	nuclear factor kappa B subunit 1	Homo sapiens	206-215
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	115-142	interleukin 18	Mus musculus	44-49
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	115-142	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	115-142	interleukin 18	Mus musculus	180-185
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	144-148	interleukin 18	Mus musculus	44-49
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	144-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
25475966-3	2015	The present study proposes a novel role for IL-18 in cholesterol efflux and plaque stability and demonstrates that pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor blocks IL-18 signaling in apolipoprotein (Apo) E-/- mice.	pyrrolidine dithiocarbamic acid	144-148	interleukin 18	Mus musculus	180-185
26062410-5	2015	The underlying mechanism involved in chemerin-induced insulin resistance was evaluated with the precondition of NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	130-157	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	37-45
26109305-4	2015	Pyrrolidine dithiocarbamate (PDTC), on the other hand, was used to inhibit NF-kappaB, a downstream effector of the TLR4 signaling pathway.	pyrrolidine dithiocarbamic acid	0-27	toll-like receptor 4	Rattus norvegicus	115-119
26109305-4	2015	Pyrrolidine dithiocarbamate (PDTC), on the other hand, was used to inhibit NF-kappaB, a downstream effector of the TLR4 signaling pathway.	pyrrolidine dithiocarbamic acid	29-33	toll-like receptor 4	Rattus norvegicus	115-119
26062410-5	2015	The underlying mechanism involved in chemerin-induced insulin resistance was evaluated with the precondition of NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	130-157	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
26062410-5	2015	The underlying mechanism involved in chemerin-induced insulin resistance was evaluated with the precondition of NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	159-163	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	37-45
25287011-1	2015	BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappaB (NF-kappaB), as well as to determine the relationship between TLR4 and NF-kappaB in ANP pathogenesis.	pyrrolidine dithiocarbamic acid	182-209	toll-like receptor 4	Rattus norvegicus	72-76
25871799-7	2015	Blocking c-Src by PP2, scavenging ROS by glutathione (GSH) or inhibiting NF-kappaB activation by pyrrolidine dithiocarbamate (PDTC) decreased TNF-alpha production from RAW264.7 cells.	pyrrolidine dithiocarbamic acid	97-124	tumor necrosis factor	Mus musculus	142-151
25871799-7	2015	Blocking c-Src by PP2, scavenging ROS by glutathione (GSH) or inhibiting NF-kappaB activation by pyrrolidine dithiocarbamate (PDTC) decreased TNF-alpha production from RAW264.7 cells.	pyrrolidine dithiocarbamic acid	126-130	tumor necrosis factor	Mus musculus	142-151
25287011-1	2015	BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappaB (NF-kappaB), as well as to determine the relationship between TLR4 and NF-kappaB in ANP pathogenesis.	pyrrolidine dithiocarbamic acid	182-209	toll-like receptor 4	Rattus norvegicus	318-322
25996379-0	2015	A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937.	pyrrolidine dithiocarbamic acid	65-92	mitogen-activated protein kinase 8	Homo sapiens	19-22
25996379-0	2015	A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937.	pyrrolidine dithiocarbamic acid	65-92	superoxide dismutase 1	Homo sapiens	101-123
25996379-1	2015	Pyrrolidine dithiocarbamate (PDTC) known as antioxidant and specific inhibitor of NF-kappaB was also described as pro-oxidant by inducing cell death and reactive oxygen species (ROS) accumulation in cancer.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	82-91
25996379-1	2015	Pyrrolidine dithiocarbamate (PDTC) known as antioxidant and specific inhibitor of NF-kappaB was also described as pro-oxidant by inducing cell death and reactive oxygen species (ROS) accumulation in cancer.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	82-91
25494456-6	2015	RESULTS: The application of paclitaxel induced an up-regulation of CX3CL1 expression in the spinal neurons, which is reduced significantly by NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate or p65 small interfering RNA.	pyrrolidine dithiocarbamic acid	162-197	C-X3-C motif chemokine ligand 1	Rattus norvegicus	67-73
25494456-9	2015	Furthermore, an increased acetylation level of H4, but not H3, in Cx3cl1 promoter region in spinal neurons was detected after paclitaxel treatment, which was reversed by inhibition of NF-kappaB with ammonium pyrrolidinedithiocarbamate or p65 small interfering RNA.	pyrrolidine dithiocarbamic acid	199-234	C-X3-C motif chemokine ligand 1	Rattus norvegicus	66-72
25740656-8	2015	Pyrrolidine dithiocarbamate treatment not only significantly inhibited NF-kappaB activity but also reduced the messenger RNA levels of E-selectin, vascular cell adhesion molecule-1, and MCP-1 as well as monocyte recruitment in the abdominal aorta of hindlimb unweighted rats.	pyrrolidine dithiocarbamic acid	0-27	selectin E	Rattus norvegicus	135-145
25740656-8	2015	Pyrrolidine dithiocarbamate treatment not only significantly inhibited NF-kappaB activity but also reduced the messenger RNA levels of E-selectin, vascular cell adhesion molecule-1, and MCP-1 as well as monocyte recruitment in the abdominal aorta of hindlimb unweighted rats.	pyrrolidine dithiocarbamic acid	0-27	vascular cell adhesion molecule 1	Rattus norvegicus	147-180
25740656-8	2015	Pyrrolidine dithiocarbamate treatment not only significantly inhibited NF-kappaB activity but also reduced the messenger RNA levels of E-selectin, vascular cell adhesion molecule-1, and MCP-1 as well as monocyte recruitment in the abdominal aorta of hindlimb unweighted rats.	pyrrolidine dithiocarbamic acid	0-27	C-C motif chemokine ligand 2	Rattus norvegicus	186-191
25448063-4	2015	In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NF-kappaB activator, tumor necrosis factor-alpha (TNF-alpha), with the inhibitor of NF-kappaB activation, pyrrolidinedithiocarbamate (PDTC), or with a related specific siRNA.	pyrrolidine dithiocarbamic acid	238-264	tumor necrosis factor	Homo sapiens	153-180
25287011-0	2015	Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis.	pyrrolidine dithiocarbamic acid	0-27	toll-like receptor 4	Rattus norvegicus	63-83
25287011-1	2015	BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappaB (NF-kappaB), as well as to determine the relationship between TLR4 and NF-kappaB in ANP pathogenesis.	pyrrolidine dithiocarbamic acid	182-209	toll-like receptor 4	Rattus norvegicus	50-70
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	135-162	nuclear factor kappa B subunit 1	Homo sapiens	30-39
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	135-162	tumor necrosis factor	Mus musculus	61-70
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	135-162	nuclear factor kappa B subunit 1	Homo sapiens	115-124
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	164-168	nuclear factor kappa B subunit 1	Homo sapiens	30-39
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	164-168	tumor necrosis factor	Mus musculus	61-70
25595974-8	2015	Conversely, the activation of NF-kappaB and up-regulation of TNF-alpha and COX-2 were blocked by pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) before being inoculated with HSV-1 to mice.	pyrrolidine dithiocarbamic acid	164-168	nuclear factor kappa B subunit 1	Homo sapiens	115-124
25893721-4	2015	The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha.	pyrrolidine dithiocarbamic acid	28-55	regulator of microtubule dynamics 3	Homo sapiens	91-98
25893721-4	2015	The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha.	pyrrolidine dithiocarbamic acid	28-55	tumor necrosis factor	Homo sapiens	129-137
25893721-4	2015	The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha.	pyrrolidine dithiocarbamic acid	57-61	regulator of microtubule dynamics 3	Homo sapiens	91-98
25893721-4	2015	The parallel treatment with pyrrolidine dithiocarbamate (PDTC) reversed the suppression of PTPIP51 protein expression induced by TNFalpha.	pyrrolidine dithiocarbamic acid	57-61	tumor necrosis factor	Homo sapiens	129-137
25637478-11	2015	In vitro treatment of endometrial cells with tumor necrosis factor-alpha caused a significant increase of NF-kB activation and Pak4 expression, which was obviously decreased by the NF-kB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	197-223	tumor necrosis factor	Homo sapiens	45-72
25637478-11	2015	In vitro treatment of endometrial cells with tumor necrosis factor-alpha caused a significant increase of NF-kB activation and Pak4 expression, which was obviously decreased by the NF-kB inhibitor pyrrolidinedithiocarbamate.	pyrrolidine dithiocarbamic acid	197-223	p21 (RAC1) activated kinase 4	Homo sapiens	127-131
25501661-8	2015	Conversely, NF-kappaB inhibition genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC) prevented cytokine, but not IL6R, induction by JunB deficiency.	pyrrolidine dithiocarbamic acid	98-125	nuclear factor kappa B subunit 1	Homo sapiens	12-21
25501661-8	2015	Conversely, NF-kappaB inhibition genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC) prevented cytokine, but not IL6R, induction by JunB deficiency.	pyrrolidine dithiocarbamic acid	98-125	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-184
25501661-8	2015	Conversely, NF-kappaB inhibition genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC) prevented cytokine, but not IL6R, induction by JunB deficiency.	pyrrolidine dithiocarbamic acid	127-131	nuclear factor kappa B subunit 1	Homo sapiens	12-21
25501661-8	2015	Conversely, NF-kappaB inhibition genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC) prevented cytokine, but not IL6R, induction by JunB deficiency.	pyrrolidine dithiocarbamic acid	127-131	NFKB inhibitor alpha	Homo sapiens	59-71
25501661-8	2015	Conversely, NF-kappaB inhibition genetically with a mutant IkappaBalpha or pharmacologically with pyrrolidine dithiocarbamate (PDTC) prevented cytokine, but not IL6R, induction by JunB deficiency.	pyrrolidine dithiocarbamic acid	127-131	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-184
26248412-7	2015	These effects could be reversed by ROS inhibitor diphenyleneiodonium (DPI) and NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	99-125	nuclear factor kappa B subunit 1	Homo sapiens	79-88
26248412-7	2015	These effects could be reversed by ROS inhibitor diphenyleneiodonium (DPI) and NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	127-131	nuclear factor kappa B subunit 1	Homo sapiens	79-88
25448063-4	2015	In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NF-kappaB activator, tumor necrosis factor-alpha (TNF-alpha), with the inhibitor of NF-kappaB activation, pyrrolidinedithiocarbamate (PDTC), or with a related specific siRNA.	pyrrolidine dithiocarbamic acid	266-270	tumor necrosis factor	Homo sapiens	153-180
25503960-5	2015	In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha.	pyrrolidine dithiocarbamic acid	119-163	C-X-C motif chemokine receptor 4	Homo sapiens	209-214
25503960-5	2015	In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha.	pyrrolidine dithiocarbamic acid	119-163	nuclear factor kappa B subunit 1	Homo sapiens	44-53
25503960-5	2015	In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha.	pyrrolidine dithiocarbamic acid	119-163	nuclear factor kappa B subunit 1	Homo sapiens	96-105
25503960-5	2015	In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha.	pyrrolidine dithiocarbamic acid	119-163	tumor necrosis factor	Homo sapiens	175-184
25973060-2	2015	The cells were administrated with hypoxia, and/or 5 muM pyrrolidine dithiocarbamate (PDTC) (a selective NF-kappaB inhibitor) to inhibit the NF-kappaB activity, expressions of NF-kappaB was measured by western blot, and the translocation of NF-kappaB was detected.	pyrrolidine dithiocarbamic acid	56-83	nuclear factor kappa B subunit 1	Homo sapiens	104-113
25973060-2	2015	The cells were administrated with hypoxia, and/or 5 muM pyrrolidine dithiocarbamate (PDTC) (a selective NF-kappaB inhibitor) to inhibit the NF-kappaB activity, expressions of NF-kappaB was measured by western blot, and the translocation of NF-kappaB was detected.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	104-113
25973060-2	2015	The cells were administrated with hypoxia, and/or 5 muM pyrrolidine dithiocarbamate (PDTC) (a selective NF-kappaB inhibitor) to inhibit the NF-kappaB activity, expressions of NF-kappaB was measured by western blot, and the translocation of NF-kappaB was detected.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	140-149
25973060-2	2015	The cells were administrated with hypoxia, and/or 5 muM pyrrolidine dithiocarbamate (PDTC) (a selective NF-kappaB inhibitor) to inhibit the NF-kappaB activity, expressions of NF-kappaB was measured by western blot, and the translocation of NF-kappaB was detected.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	140-149
25973060-2	2015	The cells were administrated with hypoxia, and/or 5 muM pyrrolidine dithiocarbamate (PDTC) (a selective NF-kappaB inhibitor) to inhibit the NF-kappaB activity, expressions of NF-kappaB was measured by western blot, and the translocation of NF-kappaB was detected.	pyrrolidine dithiocarbamic acid	85-89	nuclear factor kappa B subunit 1	Homo sapiens	140-149
25635831-6	2015	Repeated intrathecal infusions of pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) decreased CCL5 expression, inhibited the activation of microglia and astrocytes, and attenuated CCI-induced allodynia and hyperalgesia.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	71-80
25635831-6	2015	Repeated intrathecal infusions of pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) decreased CCL5 expression, inhibited the activation of microglia and astrocytes, and attenuated CCI-induced allodynia and hyperalgesia.	pyrrolidine dithiocarbamic acid	34-61	C-C motif chemokine ligand 5	Homo sapiens	102-106
25635831-6	2015	Repeated intrathecal infusions of pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) decreased CCL5 expression, inhibited the activation of microglia and astrocytes, and attenuated CCI-induced allodynia and hyperalgesia.	pyrrolidine dithiocarbamic acid	63-67	nuclear factor kappa B subunit 1	Homo sapiens	71-80
25635831-6	2015	Repeated intrathecal infusions of pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor) decreased CCL5 expression, inhibited the activation of microglia and astrocytes, and attenuated CCI-induced allodynia and hyperalgesia.	pyrrolidine dithiocarbamic acid	63-67	C-C motif chemokine ligand 5	Homo sapiens	102-106
25433287-4	2015	Further studies indicated that HCVcc infection activated nuclear factor-kappa B (NF-kappaB) and the upregulation of miR-221 by HCVcc infection could totally blocked by NF-kappaB inhibitor (pyrrolidine dithiocarbamate, PDTC).	pyrrolidine dithiocarbamic acid	189-216	nuclear factor kappa B subunit 1	Homo sapiens	57-79
25433287-4	2015	Further studies indicated that HCVcc infection activated nuclear factor-kappa B (NF-kappaB) and the upregulation of miR-221 by HCVcc infection could totally blocked by NF-kappaB inhibitor (pyrrolidine dithiocarbamate, PDTC).	pyrrolidine dithiocarbamic acid	189-216	nuclear factor kappa B subunit 1	Homo sapiens	81-90
25433287-4	2015	Further studies indicated that HCVcc infection activated nuclear factor-kappa B (NF-kappaB) and the upregulation of miR-221 by HCVcc infection could totally blocked by NF-kappaB inhibitor (pyrrolidine dithiocarbamate, PDTC).	pyrrolidine dithiocarbamic acid	189-216	microRNA 221	Homo sapiens	116-123
25433287-4	2015	Further studies indicated that HCVcc infection activated nuclear factor-kappa B (NF-kappaB) and the upregulation of miR-221 by HCVcc infection could totally blocked by NF-kappaB inhibitor (pyrrolidine dithiocarbamate, PDTC).	pyrrolidine dithiocarbamic acid	189-216	nuclear factor kappa B subunit 1	Homo sapiens	168-177
25503960-5	2015	In addition, this effect was dependent upon NF-kappaB transcriptional activity, as blocking the NF-kappaB pathway with pyrrolidinedithiocarbamic acid ammonium salt suppressed TNF-alpha-induced upregulation of CXCR4 expression and reduced the migration towards the CXCR4 ligand, SDF-1alpha.	pyrrolidine dithiocarbamic acid	119-163	C-X-C motif chemokine receptor 4	Homo sapiens	264-269
25871324-9	2015	The effects of 5"-Cl on mitochondria and apoptosis were substantially blocked in the presence of a combination between z-VAD-FMK and either of the ROS scavenger N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	190-217	X-linked Kx blood group	Homo sapiens	182-185
25871324-9	2015	The effects of 5"-Cl on mitochondria and apoptosis were substantially blocked in the presence of a combination between z-VAD-FMK and either of the ROS scavenger N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	219-223	X-linked Kx blood group	Homo sapiens	182-185
26843885-5	2015	Additionally, IRS1 protein expression exposed to OA was detected after using pyrrolidine dithiocarbamate (PDTC).Our results revealed that OA decreased the glucose content in HepG2 cells in vitro.	pyrrolidine dithiocarbamic acid	77-104	insulin receptor substrate 1	Homo sapiens	14-18
26843885-5	2015	Additionally, IRS1 protein expression exposed to OA was detected after using pyrrolidine dithiocarbamate (PDTC).Our results revealed that OA decreased the glucose content in HepG2 cells in vitro.	pyrrolidine dithiocarbamic acid	106-110	insulin receptor substrate 1	Homo sapiens	14-18
25445966-6	2015	Consistent with the inhibition of iNOS and COX-2 via NF-kappaB activity with 5-DRL, an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), also led to the suppression of LPS-induced iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	111-138	nitric oxide synthase 2, inducible	Mus musculus	34-38
25445966-6	2015	Consistent with the inhibition of iNOS and COX-2 via NF-kappaB activity with 5-DRL, an inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC), also led to the suppression of LPS-induced iNOS and COX-2 expression.	pyrrolidine dithiocarbamic acid	111-138	prostaglandin-endoperoxide synthase 2	Mus musculus	43-48
25303486-10	2015	Lipopolysaccharide stimulation increased WNT5a expression in KGN cells and mural GCs, and BAY-117082 and pyrrolidinedithiocarbamic acid [nuclear factor-kappaB (NF-kappaB) inhibitor] treatments suppressed WNT5a mRNA below the control level.	pyrrolidine dithiocarbamic acid	105-135	nuclear factor kappa B subunit 1	Homo sapiens	137-158
25481183-5	2014	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, was used to investigate the effect of NF-kappaB on hBD-2 expression.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	52-61
25303486-10	2015	Lipopolysaccharide stimulation increased WNT5a expression in KGN cells and mural GCs, and BAY-117082 and pyrrolidinedithiocarbamic acid [nuclear factor-kappaB (NF-kappaB) inhibitor] treatments suppressed WNT5a mRNA below the control level.	pyrrolidine dithiocarbamic acid	105-135	nuclear factor kappa B subunit 1	Homo sapiens	160-169
25303486-10	2015	Lipopolysaccharide stimulation increased WNT5a expression in KGN cells and mural GCs, and BAY-117082 and pyrrolidinedithiocarbamic acid [nuclear factor-kappaB (NF-kappaB) inhibitor] treatments suppressed WNT5a mRNA below the control level.	pyrrolidine dithiocarbamic acid	105-135	Wnt family member 5A	Homo sapiens	204-209
25454762-6	2014	Pretreatment with pyrrolidine dithiocarbamate, a specific NF-kappaB inhibitor, showed the down-regulation of LPS-induced iNOS and COX-2 messenger RNA by suppressing NF-kappaB activity.	pyrrolidine dithiocarbamic acid	18-45	nitric oxide synthase 2, inducible	Mus musculus	121-125
25454762-6	2014	Pretreatment with pyrrolidine dithiocarbamate, a specific NF-kappaB inhibitor, showed the down-regulation of LPS-induced iNOS and COX-2 messenger RNA by suppressing NF-kappaB activity.	pyrrolidine dithiocarbamic acid	18-45	prostaglandin-endoperoxide synthase 2	Mus musculus	130-135
25481183-5	2014	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, was used to investigate the effect of NF-kappaB on hBD-2 expression.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	52-61
25628779-11	2014	In addition, valsartan, fenofibrate and PDTC may inhibit the AT1-AA induced atherosclerosis.	pyrrolidine dithiocarbamic acid	40-44	angiotensin II receptor, type 1a	Mus musculus	61-64
24684441-4	2014	SuHx rats were treated from Days 1 to 3, 1 to 21, and 29 to 42 with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and/or from Days 1 to 21 with anti-IL-6 antibody.	pyrrolidine dithiocarbamic acid	92-119	nuclear factor kappa B subunit 1	Homo sapiens	72-81
24952131-0	2014	Suppression of prolactin signaling by pyrrolidine dithiocarbamate is alleviated by N-acetylcysteine in mammary epithelial cells.	pyrrolidine dithiocarbamic acid	38-65	prolactin	Homo sapiens	15-24
24952131-3	2014	Here we examined the effect of pyrrolidine dithiocarbamate (PDTC) on prolactin signaling.	pyrrolidine dithiocarbamic acid	31-58	prolactin	Homo sapiens	69-78
24952131-3	2014	Here we examined the effect of pyrrolidine dithiocarbamate (PDTC) on prolactin signaling.	pyrrolidine dithiocarbamic acid	60-64	prolactin	Homo sapiens	69-78
25412187-5	2015	Our results demonstrated that treatment of the cells with 400 microM sodium hydrogen sulfide (NaHS, a donor of H2S) or 100 microM pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-kappaB) for 30 min prior to exposure to HG markedly attenuated the HG-induced increase in the expression levels of the phosphorylated (p)-NF-kappaB p65 subunit.	pyrrolidine dithiocarbamic acid	130-157	synaptotagmin 1	Rattus norvegicus	332-335
25412187-5	2015	Our results demonstrated that treatment of the cells with 400 microM sodium hydrogen sulfide (NaHS, a donor of H2S) or 100 microM pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-kappaB) for 30 min prior to exposure to HG markedly attenuated the HG-induced increase in the expression levels of the phosphorylated (p)-NF-kappaB p65 subunit.	pyrrolidine dithiocarbamic acid	159-163	synaptotagmin 1	Rattus norvegicus	332-335
25412187-7	2015	In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha).	pyrrolidine dithiocarbamic acid	53-57	interleukin 1 beta	Rattus norvegicus	147-155
25412187-7	2015	In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha).	pyrrolidine dithiocarbamic acid	53-57	interleukin 6	Rattus norvegicus	157-161
25412187-7	2015	In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha).	pyrrolidine dithiocarbamic acid	53-57	tumor necrosis factor	Rattus norvegicus	166-193
25412187-7	2015	In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha).	pyrrolidine dithiocarbamic acid	53-57	tumor necrosis factor	Rattus norvegicus	195-204
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	nuclear factor kappa B subunit 1	Homo sapiens	230-239
25333664-6	2014	Pretreatment with a COX-2 or NF-kappaB-selective inhibitor (celecoxib or ammonium pyrrolidinedithiocarbamate) had an additive effect on the effusanin E-mediated inhibition of proliferation, while pretreatment with an activator of NF-kappaB/COX-2 (lipopolysaccharides) abrogated the effusanin E-mediated inhibition of proliferation.	pyrrolidine dithiocarbamic acid	73-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	240-245
25314575-4	2014	Moreover, the ectopic proliferation was completely inhibited by ammonium pyrrolidinedithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	64-99	nuclear factor kappa B subunit 1	Homo sapiens	111-120
25314575-4	2014	Moreover, the ectopic proliferation was completely inhibited by ammonium pyrrolidinedithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	101-105	nuclear factor kappa B subunit 1	Homo sapiens	111-120
25187802-4	2014	In two additional groups, toll-like receptor 4 (TLR4) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) were inhibited by a TLR4 antibody and pyrrolidine dithiocarbamate, respectively.	pyrrolidine dithiocarbamic acid	171-198	toll like receptor 4	Homo sapiens	26-46
25187802-4	2014	In two additional groups, toll-like receptor 4 (TLR4) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) were inhibited by a TLR4 antibody and pyrrolidine dithiocarbamate, respectively.	pyrrolidine dithiocarbamic acid	171-198	toll like receptor 4	Homo sapiens	48-52
25187802-4	2014	In two additional groups, toll-like receptor 4 (TLR4) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) were inhibited by a TLR4 antibody and pyrrolidine dithiocarbamate, respectively.	pyrrolidine dithiocarbamic acid	171-198	nuclear factor kappa B subunit 1	Homo sapiens	122-131
24700312-5	2014	Further studies demonstrated that the mRNA and protein expression levels of hBD-2 were attenuated by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, the extracellular signal-regulated kinase (ERK) inhibitor PD98059, and the nuclear factor kappa B (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate (PDTC)).	pyrrolidine dithiocarbamic acid	294-321	defensin beta 4A	Homo sapiens	76-81
24700312-5	2014	Further studies demonstrated that the mRNA and protein expression levels of hBD-2 were attenuated by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, the extracellular signal-regulated kinase (ERK) inhibitor PD98059, and the nuclear factor kappa B (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate (PDTC)).	pyrrolidine dithiocarbamic acid	323-327	defensin beta 4A	Homo sapiens	76-81
24740410-9	2014	Finally, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced LPS-induced upregulation of RAGE expression at both protein and messenger RNA (mRNA) levels in AECIs.	pyrrolidine dithiocarbamic acid	29-56	advanced glycosylation end product-specific receptor	Rattus norvegicus	114-118
24740410-9	2014	Finally, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly reduced LPS-induced upregulation of RAGE expression at both protein and messenger RNA (mRNA) levels in AECIs.	pyrrolidine dithiocarbamic acid	58-62	advanced glycosylation end product-specific receptor	Rattus norvegicus	114-118
24594834-1	2014	We aimed to delineate how pyrrolidine dithiocarbamate (PDTC) affects nuclear factor kappaB (NF-kappaB) and to determine its antitumor activity alone and in combination with cisplatin in human cervical cancer SiHa cells.	pyrrolidine dithiocarbamic acid	26-53	nuclear factor kappa B subunit 1	Homo sapiens	92-101
24594834-1	2014	We aimed to delineate how pyrrolidine dithiocarbamate (PDTC) affects nuclear factor kappaB (NF-kappaB) and to determine its antitumor activity alone and in combination with cisplatin in human cervical cancer SiHa cells.	pyrrolidine dithiocarbamic acid	55-59	nuclear factor kappa B subunit 1	Homo sapiens	92-101
25109280-9	2014	The further study confirmed that ERK1/2 inhibitor PD98059 and NF-kappaB inhibitor pyrrolidine dithiocarbamate both depressed aldosterone-induced CRP expression.	pyrrolidine dithiocarbamic acid	82-109	C-reactive protein	Rattus norvegicus	145-148
25120710-6	2014	Furthermore, treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed cell invasion and MMP-2 expression.	pyrrolidine dithiocarbamic acid	53-80	nuclear factor kappa B subunit 1	Homo sapiens	32-41
24893330-6	2014	Intrathecal injection of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated the pain behaviors and over-expression of Nav1.7 in DRG neurons.	pyrrolidine dithiocarbamic acid	45-72	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	147-153
24893330-6	2014	Intrathecal injection of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly attenuated the pain behaviors and over-expression of Nav1.7 in DRG neurons.	pyrrolidine dithiocarbamic acid	74-78	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	147-153
24970592-2	2014	Human gastric carcinoma SGC-7901 cells were treated with temperate concentrations of VES and pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	93-120	nuclear factor kappa B subunit 1	Homo sapiens	145-154
24970592-2	2014	Human gastric carcinoma SGC-7901 cells were treated with temperate concentrations of VES and pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	122-126	nuclear factor kappa B subunit 1	Homo sapiens	145-154
25120710-6	2014	Furthermore, treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, suppressed cell invasion and MMP-2 expression.	pyrrolidine dithiocarbamic acid	53-80	matrix metallopeptidase 2	Homo sapiens	111-116
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	89-119	nuclear factor kappa B subunit 1	Homo sapiens	52-78
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	135-162	trans-golgi network vesicle protein 23 homolog B	Homo sapiens	95-101
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	135-162	nuclear factor kappa B subunit 1	Homo sapiens	182-204
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	135-162	nuclear factor kappa B subunit 1	Homo sapiens	206-215
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	164-168	trans-golgi network vesicle protein 23 homolog B	Homo sapiens	95-101
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	164-168	nuclear factor kappa B subunit 1	Homo sapiens	182-204
25221423-11	2014	The enhanced migration, tube formation, and decrease in the viability of HRMECs as a result of FAM18B downregulation was reversed with pyrrolidine dithiocarbamate (PDTC), a specific nuclear factor-kappa B (NF-kappaB) inhibitor.	pyrrolidine dithiocarbamic acid	164-168	nuclear factor kappa B subunit 1	Homo sapiens	206-215
24613819-6	2014	Specific NF-kappaB inhibitors, pyrrolidine dithiocarbamate, MG132, and PS-1145, also attenuated TNF-alpha-mediated MMP-9 and VEGF expression as well as activity by suppressing their regulatory genes.	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	9-18
24613819-6	2014	Specific NF-kappaB inhibitors, pyrrolidine dithiocarbamate, MG132, and PS-1145, also attenuated TNF-alpha-mediated MMP-9 and VEGF expression as well as activity by suppressing their regulatory genes.	pyrrolidine dithiocarbamic acid	31-58	tumor necrosis factor	Homo sapiens	96-105
24613819-6	2014	Specific NF-kappaB inhibitors, pyrrolidine dithiocarbamate, MG132, and PS-1145, also attenuated TNF-alpha-mediated MMP-9 and VEGF expression as well as activity by suppressing their regulatory genes.	pyrrolidine dithiocarbamic acid	31-58	matrix metallopeptidase 9	Homo sapiens	115-120
24613819-6	2014	Specific NF-kappaB inhibitors, pyrrolidine dithiocarbamate, MG132, and PS-1145, also attenuated TNF-alpha-mediated MMP-9 and VEGF expression as well as activity by suppressing their regulatory genes.	pyrrolidine dithiocarbamic acid	31-58	vascular endothelial growth factor A	Homo sapiens	125-129
24999732-8	2014	We addressed whether selective inhibition of NF-kappaB suppresses the NRP1-mediated EMT by treating cells with pyrrolidinedithiocarbamate ammonium (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	111-146	nuclear factor kappa B subunit 1	Homo sapiens	45-54
24999732-8	2014	We addressed whether selective inhibition of NF-kappaB suppresses the NRP1-mediated EMT by treating cells with pyrrolidinedithiocarbamate ammonium (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	111-146	neuropilin 1	Homo sapiens	70-74
24999732-8	2014	We addressed whether selective inhibition of NF-kappaB suppresses the NRP1-mediated EMT by treating cells with pyrrolidinedithiocarbamate ammonium (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	111-146	nuclear factor kappa B subunit 1	Homo sapiens	171-180
24829401-0	2014	Pyrrolidine dithiocarbamate protects pancreatic beta-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats.	pyrrolidine dithiocarbamic acid	0-27	forkhead box O1	Rattus norvegicus	103-108
24935539-8	2014	The CaMKII inhibitor KN-93 significantly attenuated and the NF-kappaB inhibitor pyrrolidine dithiocarbamate further enhanced the up-regulation of Biodentine-induced gene expression and mineralization.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor kappa B subunit 1	Homo sapiens	60-69
24859013-5	2014	Treatment with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), indirectly showed that NF-kappaB is a crucial transcription factor for expression of these genes in the early stage of inflammation.	pyrrolidine dithiocarbamic acid	47-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
24859013-5	2014	Treatment with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), indirectly showed that NF-kappaB is a crucial transcription factor for expression of these genes in the early stage of inflammation.	pyrrolidine dithiocarbamic acid	47-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115
24859013-5	2014	Treatment with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), indirectly showed that NF-kappaB is a crucial transcription factor for expression of these genes in the early stage of inflammation.	pyrrolidine dithiocarbamic acid	76-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
24859013-5	2014	Treatment with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), indirectly showed that NF-kappaB is a crucial transcription factor for expression of these genes in the early stage of inflammation.	pyrrolidine dithiocarbamic acid	76-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115
24753106-4	2014	Consistent with this finding, the growth of NPC neurospheres was increased by lentivirus-mediated overexpression of Nrf2 gene or by treatment with pyrrolidine dithiocarbamate (PDTC), an Nrf2 activating compound.	pyrrolidine dithiocarbamic acid	147-174	NFE2 like bZIP transcription factor 2	Homo sapiens	186-190
24753106-4	2014	Consistent with this finding, the growth of NPC neurospheres was increased by lentivirus-mediated overexpression of Nrf2 gene or by treatment with pyrrolidine dithiocarbamate (PDTC), an Nrf2 activating compound.	pyrrolidine dithiocarbamic acid	176-180	NFE2 like bZIP transcription factor 2	Homo sapiens	186-190
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	pyrrolidine dithiocarbamic acid	241-245	RELA proto-oncogene, NF-kB subunit	Homo sapiens	30-33
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	pyrrolidine dithiocarbamic acid	241-245	MIR7-3 host gene	Homo sapiens	66-71
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	pyrrolidine dithiocarbamic acid	241-245	AKT serine/threonine kinase 1	Homo sapiens	113-116
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	pyrrolidine dithiocarbamic acid	241-245	prostaglandin E receptor 4	Homo sapiens	150-154
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	pyrrolidine dithiocarbamic acid	241-245	nuclear factor kappa B subunit 1	Homo sapiens	192-201
24760979-4	2014	The knockdown of Akt by siRNA technology and blocking the nuclear factor-kappaB (NF-kappaB) pathway using pyrrolidine dithiocarbamate (PDTC) and SN50, inhibitors of NF-kappaB, both attenuated the HMGB1-induced proliferation by counteracting the activation of the cyclin D1.	pyrrolidine dithiocarbamic acid	106-133	high mobility group box 1	Mus musculus	196-201
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	89-119	beclin 1	Homo sapiens	146-154
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	89-119	cytochrome c, somatic	Homo sapiens	180-192
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	89-119	caspase 3	Homo sapiens	202-211
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	89-119	poly(ADP-ribose) polymerase 1	Homo sapiens	228-232
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	121-125	nuclear factor kappa B subunit 1	Homo sapiens	52-78
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	121-125	beclin 1	Homo sapiens	146-154
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	121-125	cytochrome c, somatic	Homo sapiens	180-192
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	121-125	caspase 3	Homo sapiens	202-211
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pyrrolidine dithiocarbamic acid	121-125	poly(ADP-ribose) polymerase 1	Homo sapiens	228-232
24754256-4	2014	Using an LPS-induced inflammatory cell model, we found that hPhT2 mRNA expression was up-regulated in THP-1 cells and that the up-regulation was suppressed by pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	159-186	toll-like receptor 4	Mus musculus	9-12
24754256-4	2014	Using an LPS-induced inflammatory cell model, we found that hPhT2 mRNA expression was up-regulated in THP-1 cells and that the up-regulation was suppressed by pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	159-186	solute carrier family 15 member 3	Homo sapiens	60-65
24754256-4	2014	Using an LPS-induced inflammatory cell model, we found that hPhT2 mRNA expression was up-regulated in THP-1 cells and that the up-regulation was suppressed by pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	159-186	GLI family zinc finger 2	Homo sapiens	102-107
24754256-4	2014	Using an LPS-induced inflammatory cell model, we found that hPhT2 mRNA expression was up-regulated in THP-1 cells and that the up-regulation was suppressed by pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	159-186	nuclear factor kappa B subunit 1	Homo sapiens	212-221
24710107-10	2014	When YC-1 (HIF-1alpha inhibitor), pyrrolidine dithiocarbamate (NF-kappaB inhibitor) or SB203580 (p38MAPK inhibitor) were used to block the activation of HIF-1alpha, NF-kappaB and p38, SMC pre-treatments did not affect the protein expression of HIF-1alpha, NF-kappaB and p-p38.	pyrrolidine dithiocarbamic acid	34-61	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	153-163
24710107-10	2014	When YC-1 (HIF-1alpha inhibitor), pyrrolidine dithiocarbamate (NF-kappaB inhibitor) or SB203580 (p38MAPK inhibitor) were used to block the activation of HIF-1alpha, NF-kappaB and p38, SMC pre-treatments did not affect the protein expression of HIF-1alpha, NF-kappaB and p-p38.	pyrrolidine dithiocarbamic acid	34-61	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	153-163
23929359-9	2014	A nuclear factor kappaB (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate) also suppressed the cell migration and MMP-1 expression enhanced by IL-17A.	pyrrolidine dithiocarbamic acid	47-74	nuclear factor kappa B subunit 1	Homo sapiens	25-34
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	128-155	vascular endothelial growth factor C	Homo sapiens	15-21
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	128-155	galectin 3	Homo sapiens	43-48
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	128-155	nuclear factor kappa B subunit 1	Homo sapiens	108-117
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	157-161	vascular endothelial growth factor C	Homo sapiens	15-21
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	157-161	galectin 3	Homo sapiens	43-48
24650367-5	2014	Treatment with VEGF-C for 12-48 h enhanced Gal-3 protein expression, which was inhibited by the addition of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	157-161	nuclear factor kappa B subunit 1	Homo sapiens	108-117
24887697-13	2014	The ALP expression in the periodontal ligament was elevated after treatment with anti-TLR4 antibody or pyrrolidinedithiocarbamate, whereas there was no statistical significance among groups for the number of osteoclasts.	pyrrolidine dithiocarbamic acid	103-129	alkaline phosphatase, placental	Homo sapiens	4-7
24940409-6	2014	Furthermore, TFPN attenuated the Ang II-induced generation of ROS and the activation of nuclear factor-kappaB (NF-kappaB); these Ang II-induced effects were also inhibited by apocynin (a nicotinamide adenine dinucleotide phosphate oxidase inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	254-281	angiotensinogen	Homo sapiens	33-39
24940409-6	2014	Furthermore, TFPN attenuated the Ang II-induced generation of ROS and the activation of nuclear factor-kappaB (NF-kappaB); these Ang II-induced effects were also inhibited by apocynin (a nicotinamide adenine dinucleotide phosphate oxidase inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	254-281	angiotensinogen	Homo sapiens	129-135
24584670-16	2014	Treatment with 17-PT-PGE2 induced NF-kappaB activation, and the selective NF-kappaB inhibitor pyrrolidinedithiocarbamate inhibited 17-PT-PGE2-mediated beta1 integrin expression.	pyrrolidine dithiocarbamic acid	94-120	nuclear factor kappa B subunit 1	Homo sapiens	74-83
24584670-16	2014	Treatment with 17-PT-PGE2 induced NF-kappaB activation, and the selective NF-kappaB inhibitor pyrrolidinedithiocarbamate inhibited 17-PT-PGE2-mediated beta1 integrin expression.	pyrrolidine dithiocarbamic acid	94-120	integrin subunit beta 1	Homo sapiens	151-165
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	37-64	nitric oxide synthase 2, inducible	Mus musculus	99-103
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	37-64	prostaglandin-endoperoxide synthase 2	Mus musculus	108-113
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	37-64	nitric oxide synthase 2, inducible	Mus musculus	203-207
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	37-64	prostaglandin-endoperoxide synthase 2	Mus musculus	212-217
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	66-70	nitric oxide synthase 2, inducible	Mus musculus	99-103
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	66-70	prostaglandin-endoperoxide synthase 2	Mus musculus	108-113
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	66-70	nitric oxide synthase 2, inducible	Mus musculus	203-207
24365262-4	2014	Furthermore, an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated LPS-stimulated iNOS and COX-2 expression, suggesting that NF-kappaB inhibition is a main effector in the expression of iNOS and COX-2.	pyrrolidine dithiocarbamic acid	66-70	prostaglandin-endoperoxide synthase 2	Mus musculus	212-217
24752587-7	2014	Histamine also activated NF-kappa B and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B, and reduced histamine-induced TNF-alpha and IL-6 release.	pyrrolidine dithiocarbamic acid	40-75	nuclear factor kappa B subunit 1	Homo sapiens	93-103
24751148-16	2014	To inhibit the positive feedback loop of TLR4-microglia-NF-kappaB/ IL-1beta pathway by minocycline, TAK-242 (TLR4 inhibitor) and pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) may provide new targets for treating I/R injury in clinic.	pyrrolidine dithiocarbamic acid	129-156	toll-like receptor 4	Rattus norvegicus	41-45
24854919-5	2014	Pyrrolidine dithiocarbamate (PDTC) (20 micromol/L, pretreatment for 20 min) was used as a specific inhibitor of nuclear transcription factor NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	141-150
24854919-5	2014	Pyrrolidine dithiocarbamate (PDTC) (20 micromol/L, pretreatment for 20 min) was used as a specific inhibitor of nuclear transcription factor NF-kappaB.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	141-150
24663080-7	2014	Finally, pyrrolidine dithiocarbamate also reduced the levels of IL-6 and TNF-alpha and the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	9-36	interleukin 6	Rattus norvegicus	64-68
24663080-7	2014	Finally, pyrrolidine dithiocarbamate also reduced the levels of IL-6 and TNF-alpha and the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	9-36	tumor necrosis factor	Rattus norvegicus	73-82
23929359-9	2014	A nuclear factor kappaB (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate) also suppressed the cell migration and MMP-1 expression enhanced by IL-17A.	pyrrolidine dithiocarbamic acid	47-74	matrix metallopeptidase 1	Homo sapiens	115-120
23929359-9	2014	A nuclear factor kappaB (NF-kappaB) inhibitor (pyrrolidine dithiocarbamate) also suppressed the cell migration and MMP-1 expression enhanced by IL-17A.	pyrrolidine dithiocarbamic acid	47-74	interleukin 17A	Homo sapiens	144-150
24336063-11	2013	Furthermore pyrrolidine dithiocarbamate (PDTC), a NF-kappaB blocker, abolished the expression of hypoxia-induced AT1R and Col-I in HLF-1 cells.	pyrrolidine dithiocarbamic acid	12-39	angiotensin II receptor type 1	Homo sapiens	113-117
24587316-8	2014	The survival-prolonging effect of TNF-alpha was reversed by inhibitors of NF-kappaB pyrrolidinedithiocarbamate and gliotoxin and by an inhibitor of IkappaB kinase, BMS-345541.	pyrrolidine dithiocarbamic acid	84-110	tumor necrosis factor	Homo sapiens	34-43
24239652-6	2014	Moreover, HA-induced iNOS and COX-2 expression were down-regulated by the NF-kappaB and AP-1 inhibitors pyrrolidine dithiocarbamate (PDTC) and Tanshinone, respectively.	pyrrolidine dithiocarbamic acid	104-131	nitric oxide synthase 2, inducible	Mus musculus	21-25
24239652-6	2014	Moreover, HA-induced iNOS and COX-2 expression were down-regulated by the NF-kappaB and AP-1 inhibitors pyrrolidine dithiocarbamate (PDTC) and Tanshinone, respectively.	pyrrolidine dithiocarbamic acid	104-131	cytochrome c oxidase II, mitochondrial	Mus musculus	30-35
24239652-6	2014	Moreover, HA-induced iNOS and COX-2 expression were down-regulated by the NF-kappaB and AP-1 inhibitors pyrrolidine dithiocarbamate (PDTC) and Tanshinone, respectively.	pyrrolidine dithiocarbamic acid	133-137	nitric oxide synthase 2, inducible	Mus musculus	21-25
24239652-6	2014	Moreover, HA-induced iNOS and COX-2 expression were down-regulated by the NF-kappaB and AP-1 inhibitors pyrrolidine dithiocarbamate (PDTC) and Tanshinone, respectively.	pyrrolidine dithiocarbamic acid	133-137	cytochrome c oxidase II, mitochondrial	Mus musculus	30-35
24225218-5	2014	Moreover, the hST8Sia I expression induced by cordycepin was significantly repressed by pyrrolidinedithiocarbamate, an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	88-114	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	14-18
24134657-12	2014	ICAM-1 and VCAM-1 expressions were also reduced by antioxidants such as pyrrolidine dithiocarbamate, diphenylene iodonium and apocynin.	pyrrolidine dithiocarbamic acid	72-99	intercellular adhesion molecule 1	Homo sapiens	0-6
24134657-12	2014	ICAM-1 and VCAM-1 expressions were also reduced by antioxidants such as pyrrolidine dithiocarbamate, diphenylene iodonium and apocynin.	pyrrolidine dithiocarbamic acid	72-99	vascular cell adhesion molecule 1	Homo sapiens	11-17
24348761-0	2014	Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial activation in the hippocampus of a pilocarpine-induced status epilepticus rat model.	pyrrolidine dithiocarbamic acid	0-27	mast cell protease 1-like 1	Rattus norvegicus	66-71
24348761-0	2014	Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial activation in the hippocampus of a pilocarpine-induced status epilepticus rat model.	pyrrolidine dithiocarbamic acid	29-33	mast cell protease 1-like 1	Rattus norvegicus	66-71
24348761-1	2014	The aim of this study was to investigate the effects of pyrrolidine dithiocarbamate (PDTC) on MCP-1 expression and microglial activation in the hippocampus of a rat model of pilocarpine (PILO)-induced status epilepticus (SE).	pyrrolidine dithiocarbamic acid	56-83	mast cell protease 1-like 1	Rattus norvegicus	94-99
24348761-1	2014	The aim of this study was to investigate the effects of pyrrolidine dithiocarbamate (PDTC) on MCP-1 expression and microglial activation in the hippocampus of a rat model of pilocarpine (PILO)-induced status epilepticus (SE).	pyrrolidine dithiocarbamic acid	85-89	mast cell protease 1-like 1	Rattus norvegicus	94-99
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	bone morphogenetic protein 2	Rattus norvegicus	25-31
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	occludin	Rattus norvegicus	87-95
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	bone morphogenetic protein 2	Rattus norvegicus	25-28
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	250-277	noggin	Rattus norvegicus	216-222
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	bone morphogenetic protein 2	Rattus norvegicus	25-31
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	occludin	Rattus norvegicus	87-95
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	bone morphogenetic protein 2	Rattus norvegicus	25-28
25132736-4	2014	Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-kappaB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	279-283	noggin	Rattus norvegicus	216-222
24363440-12	2014	Pyrrolidinedithiocarbamic acid, an inhibitor of NF-kappaB, abolished the elevation of ICAM1 but not COX2.	pyrrolidine dithiocarbamic acid	0-30	nuclear factor kappa B subunit 1	Homo sapiens	48-57
24363440-12	2014	Pyrrolidinedithiocarbamic acid, an inhibitor of NF-kappaB, abolished the elevation of ICAM1 but not COX2.	pyrrolidine dithiocarbamic acid	0-30	intercellular adhesion molecule 1	Homo sapiens	86-91
24022598-7	2014	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression.	pyrrolidine dithiocarbamic acid	33-60	nuclear factor kappa B subunit 1	Homo sapiens	13-22
24022598-7	2014	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression.	pyrrolidine dithiocarbamic acid	33-60	CD40 molecule	Homo sapiens	107-111
24022598-7	2014	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression.	pyrrolidine dithiocarbamic acid	62-66	nuclear factor kappa B subunit 1	Homo sapiens	13-22
24022598-7	2014	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression.	pyrrolidine dithiocarbamic acid	62-66	CD40 molecule	Homo sapiens	107-111
24379122-5	2014	Furthermore, tmTNF-alpha caused p38 phosphorylation and NF-kappaB activation, whereas inhibition of NF-kappaB or p38 with an inhibitor pyrrolidine dithiocarbamate or SB203580 abrogated tmTNF-alpha-mediated increased suppression of lymphocyte proliferation by MDSCs.	pyrrolidine dithiocarbamic acid	135-162	mitogen-activated protein kinase 14	Mus musculus	113-116
25198883-8	2014	To test the role of oxidative stress and NFkappaB in hypertension, prehypertensive SHR were treated with NFkappaB inhibitor pyrrolidine dithiocarbamate from 5 weeks to 11-12 weeks of age.	pyrrolidine dithiocarbamic acid	124-151	nuclear factor kappa B subunit 1	Homo sapiens	105-113
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrrolidine dithiocarbamic acid	53-80	nuclear factor kappa B subunit 1	Homo sapiens	33-42
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrrolidine dithiocarbamic acid	53-80	ATP binding cassette subfamily B member 1	Homo sapiens	117-121
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrrolidine dithiocarbamic acid	82-86	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrrolidine dithiocarbamic acid	82-86	nuclear factor kappa B subunit 1	Homo sapiens	33-42
24088727-7	2014	The c-Jun inhibitor SP600125 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells.	pyrrolidine dithiocarbamic acid	82-86	ATP binding cassette subfamily B member 1	Homo sapiens	117-121
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	pyrrolidine dithiocarbamic acid	89-116	mitogen-activated protein kinase 1	Homo sapiens	22-25
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	pyrrolidine dithiocarbamic acid	89-116	nuclear factor kappa B subunit 1	Homo sapiens	36-44
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	pyrrolidine dithiocarbamic acid	89-116	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	160-166
25762441-4	2014	These improvements could be inhibited by specific AT1 receptor blocker valsartan, NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC), and specific short peptides from the second extracellular loop of AT1 receptor.	pyrrolidine dithiocarbamic acid	100-127	nuclear factor kappa B subunit 1	Homo sapiens	82-91
25762441-4	2014	These improvements could be inhibited by specific AT1 receptor blocker valsartan, NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC), and specific short peptides from the second extracellular loop of AT1 receptor.	pyrrolidine dithiocarbamic acid	100-127	angiotensin II receptor type 1	Homo sapiens	202-205
25762441-4	2014	These improvements could be inhibited by specific AT1 receptor blocker valsartan, NF-kappaB blocker pyrrolidine dithiocarbamate (PDTC), and specific short peptides from the second extracellular loop of AT1 receptor.	pyrrolidine dithiocarbamic acid	129-133	angiotensin II receptor type 1	Homo sapiens	202-205
24088896-3	2013	On the basis of a growing body of evidence that phenethyl isothiocyanate (PEITC) and pyrrolidine dithiocarbamate (PDTC) function as antioxidants and suppressors of NF-kappaB activation, we investigated their potential ability to restore a normal phenotype in Cyp1B1-deficient (cyp1b1(-/-)) vascular cells.	pyrrolidine dithiocarbamic acid	114-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	259-265
24088896-3	2013	On the basis of a growing body of evidence that phenethyl isothiocyanate (PEITC) and pyrrolidine dithiocarbamate (PDTC) function as antioxidants and suppressors of NF-kappaB activation, we investigated their potential ability to restore a normal phenotype in Cyp1B1-deficient (cyp1b1(-/-)) vascular cells.	pyrrolidine dithiocarbamic acid	114-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	277-283
24436987-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	13-23
24436987-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	113-123
24436987-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926.	pyrrolidine dithiocarbamic acid	34-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
24436987-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	113-123
24436987-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926.	pyrrolidine dithiocarbamic acid	34-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	166-169
24057237-1	2013	The aim of the present study was to evaluate the protective effects of the NF-kB inhibition with pyrrolidine-dithiocarbamate (PDTC) in ischemia-reperfusion (I/R) injury in the rat bladder.	pyrrolidine dithiocarbamic acid	97-124	nuclear factor kappa B subunit 1	Rattus norvegicus	75-80
23735732-8	2013	After application of iNOS inhibitor S-methylisothiourea and NF-kappaB inhibitor pyrrolidine dithiocarbamate, the protective effect of resveratrol was significantly augmented by attenuating iNOS and NO production, indicating that resveratrol exerted its protective effect on intestinal I/R injury via NF-kappaB-mediated iNOS pathway.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
23609920-9	2013	N-acetyl- L-cysteine (NAC), NG-nitro-L-arginine methyl ester (L-NAME) and pyrrolidine dithiocarbamate (PDTC), partially rescued apoptotic beta-cells, suggesting involvement of NF-kappaB-iNOS-nitrite in this process.	pyrrolidine dithiocarbamic acid	74-101	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	176-185
23609920-9	2013	N-acetyl- L-cysteine (NAC), NG-nitro-L-arginine methyl ester (L-NAME) and pyrrolidine dithiocarbamate (PDTC), partially rescued apoptotic beta-cells, suggesting involvement of NF-kappaB-iNOS-nitrite in this process.	pyrrolidine dithiocarbamic acid	74-101	nitric oxide synthase 2, inducible	Mus musculus	186-190
24002221-7	2013	Calphostin C (Cal C), a protein kinase C (PKC) inhibitor, and pyrrolidine dithiocarbamate (PDTC) , an NF-kappaB inhibitor, blocked IL-8 expression in a concentration-dependent manner in pyocyanin-induced U937 cells.	pyrrolidine dithiocarbamic acid	62-89	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24002221-7	2013	Calphostin C (Cal C), a protein kinase C (PKC) inhibitor, and pyrrolidine dithiocarbamate (PDTC) , an NF-kappaB inhibitor, blocked IL-8 expression in a concentration-dependent manner in pyocyanin-induced U937 cells.	pyrrolidine dithiocarbamic acid	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24513509-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	13-23
24513509-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	113-123
24513509-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA.	pyrrolidine dithiocarbamic acid	34-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
24513509-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA.	pyrrolidine dithiocarbamic acid	34-61	nuclear factor kappa B subunit 1	Homo sapiens	113-123
24513509-7	2013	The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA.	pyrrolidine dithiocarbamic acid	34-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	166-169
23665308-7	2013	Furthermore, inhibition of NF-kappaB with pyrrolidine dithiocarbamate before exposure of cultured human conjunctival epithelial cells to ozone prevented changes in IkappaBalpha and p-IkappaBalpha levels in association with a decrease in the levels of inflammatory cytokines.	pyrrolidine dithiocarbamic acid	42-69	NFKB inhibitor alpha	Homo sapiens	164-176
23665308-7	2013	Furthermore, inhibition of NF-kappaB with pyrrolidine dithiocarbamate before exposure of cultured human conjunctival epithelial cells to ozone prevented changes in IkappaBalpha and p-IkappaBalpha levels in association with a decrease in the levels of inflammatory cytokines.	pyrrolidine dithiocarbamic acid	42-69	NFKB inhibitor alpha	Homo sapiens	183-195
24057237-1	2013	The aim of the present study was to evaluate the protective effects of the NF-kB inhibition with pyrrolidine-dithiocarbamate (PDTC) in ischemia-reperfusion (I/R) injury in the rat bladder.	pyrrolidine dithiocarbamic acid	126-130	nuclear factor kappa B subunit 1	Rattus norvegicus	75-80
23720426-7	2013	Chromatin immunoprecipitation analysis showed that NFkappaB binding to the Cox-2 promoter increased at 12 hours after progesterone withdrawal in vivo, and real-time PCR analysis showed that the NFkappaB inhibitors pyrrolidine dithiocarbamate and MG-132 inhibited Cox-2 mRNA expression in vivo and in vitro, respectively.	pyrrolidine dithiocarbamic acid	214-241	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	51-59
23884085-6	2013	The potential involvement of the nuclear factor NF-kappaB in LPS-induced CYP2A13 downregulation was suggested by identification of putative NF-kappaB binding sites within the LPS response regions and effects of an NF-kappaB inhibitor (pyrrolidine dithiocarbamate) on CYP2A13 expression in H441 cells.	pyrrolidine dithiocarbamic acid	235-262	nuclear factor kappa B subunit 1	Homo sapiens	48-57
23884085-6	2013	The potential involvement of the nuclear factor NF-kappaB in LPS-induced CYP2A13 downregulation was suggested by identification of putative NF-kappaB binding sites within the LPS response regions and effects of an NF-kappaB inhibitor (pyrrolidine dithiocarbamate) on CYP2A13 expression in H441 cells.	pyrrolidine dithiocarbamic acid	235-262	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	73-80
24133577-11	2013	This CsA-induced enhancement in the expression and migration of trophoblasts was abolished by pretreatment with pyrrolidine dithiocarbamate, a specific NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	112-139	nuclear factor kappa B subunit 1	Homo sapiens	152-161
23933318-6	2013	Pharmacological inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1beta increase and NF-kappaB signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task.	pyrrolidine dithiocarbamic acid	54-81	interleukin 1 beta	Rattus norvegicus	106-114
24065232-9	2013	After the HepG2 cells recurred the S100A4 levels, the HepG2 cells was treated with 5 microM Pyrrolidine Dithiocarbamate (PDTC) (a selective NF kappa B inhibitor) to inhibit the NF-kB activity, or treated with Batimast (BB94: a MMPs inhibitor) to inhibit the MMP-9 activity.	pyrrolidine dithiocarbamic acid	121-125	matrix metallopeptidase 9	Homo sapiens	227-231
24065232-9	2013	After the HepG2 cells recurred the S100A4 levels, the HepG2 cells was treated with 5 microM Pyrrolidine Dithiocarbamate (PDTC) (a selective NF kappa B inhibitor) to inhibit the NF-kB activity, or treated with Batimast (BB94: a MMPs inhibitor) to inhibit the MMP-9 activity.	pyrrolidine dithiocarbamic acid	121-125	matrix metallopeptidase 9	Homo sapiens	258-263
24065232-16	2013	Pretreatment with PDTC or BB94 was observed to significantly reduce NF-kB activity and MMP-9 expression and dramatically decreased S100A4 -induced invasion.	pyrrolidine dithiocarbamic acid	18-22	matrix metallopeptidase 9	Homo sapiens	87-92
24065232-16	2013	Pretreatment with PDTC or BB94 was observed to significantly reduce NF-kB activity and MMP-9 expression and dramatically decreased S100A4 -induced invasion.	pyrrolidine dithiocarbamic acid	18-22	S100 calcium binding protein A4	Homo sapiens	131-137
23743065-6	2013	Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, significantly ameliorated the dopaminergic deficits induced by MPTP in wild-type mice.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48
23743065-6	2013	Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, significantly ameliorated the dopaminergic deficits induced by MPTP in wild-type mice.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48
23947625-7	2013	Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Homo sapiens	190-199
23947625-7	2013	Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	204-208
23720426-7	2013	Chromatin immunoprecipitation analysis showed that NFkappaB binding to the Cox-2 promoter increased at 12 hours after progesterone withdrawal in vivo, and real-time PCR analysis showed that the NFkappaB inhibitors pyrrolidine dithiocarbamate and MG-132 inhibited Cox-2 mRNA expression in vivo and in vitro, respectively.	pyrrolidine dithiocarbamic acid	214-241	cytochrome c oxidase II, mitochondrial	Mus musculus	75-80
23720426-7	2013	Chromatin immunoprecipitation analysis showed that NFkappaB binding to the Cox-2 promoter increased at 12 hours after progesterone withdrawal in vivo, and real-time PCR analysis showed that the NFkappaB inhibitors pyrrolidine dithiocarbamate and MG-132 inhibited Cox-2 mRNA expression in vivo and in vitro, respectively.	pyrrolidine dithiocarbamic acid	214-241	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	194-202
23720426-9	2013	In addition, the CD45(+) leukocyte numbers were sharply reduced following indomethacin (COX-1 and COX-2 inhibitor), DuP-697 (COX-2 inhibitor), and pyrrolidine dithiocarbamate (NFkappaB inhibitor) treatment.	pyrrolidine dithiocarbamic acid	147-174	protein tyrosine phosphatase, receptor type, C	Mus musculus	17-21
23720426-9	2013	In addition, the CD45(+) leukocyte numbers were sharply reduced following indomethacin (COX-1 and COX-2 inhibitor), DuP-697 (COX-2 inhibitor), and pyrrolidine dithiocarbamate (NFkappaB inhibitor) treatment.	pyrrolidine dithiocarbamic acid	147-174	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta	Mus musculus	176-194
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	31-58	interleukin 1 beta	Rattus norvegicus	194-202
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	31-58	interleukin 6	Rattus norvegicus	207-211
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	31-58	tumor necrosis factor	Rattus norvegicus	224-233
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	60-64	interleukin 1 beta	Rattus norvegicus	194-202
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	60-64	interleukin 6	Rattus norvegicus	207-211
23807148-6	2013	The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells.	pyrrolidine dithiocarbamic acid	60-64	tumor necrosis factor	Rattus norvegicus	224-233
23567262-4	2013	Stimulation of podocytes with the cytokines TNF-alpha and IL-1beta up-regulated UCH-L1 expression rapidly at the mRNA and protein levels and the NF-kappaB-specific inhibitor pyrrolidine dithiocarbamate resulted in down-regulation.	pyrrolidine dithiocarbamic acid	174-201	tumor necrosis factor	Homo sapiens	44-53
23567262-4	2013	Stimulation of podocytes with the cytokines TNF-alpha and IL-1beta up-regulated UCH-L1 expression rapidly at the mRNA and protein levels and the NF-kappaB-specific inhibitor pyrrolidine dithiocarbamate resulted in down-regulation.	pyrrolidine dithiocarbamic acid	174-201	nuclear factor kappa B subunit 1	Homo sapiens	145-154
23619396-5	2013	The effect of ET-1 was diminished by an ETB antagonist (1 muM BQ788) or inhibitors of Sp1 (500 nM mithramycin), ERK (50 muM PD98059), p38 (20 muM SB203580) and JNK (1 muM SP600125), but not inhibitors of NF-kappaB (10 muM SN50 and 100 muM pyrrolidine dithiocarbamate).	pyrrolidine dithiocarbamic acid	239-266	endothelin 1	Rattus norvegicus	14-18
23331101-9	2013	MMP-13 expression induced by CpG ODN was markedly suppressed by NF-kappaB inhibitors (pyrrolidine dithiocarbamate, PDTC), IkappaBalpha phosphorylation inhibitors (Bay 117082) or IkappaB protease inhibitor (L-1-tosylamido-2-phenylethyl chloromethyl ketone, TPCK).	pyrrolidine dithiocarbamic acid	86-113	matrix metallopeptidase 13	Mus musculus	0-6
23331101-9	2013	MMP-13 expression induced by CpG ODN was markedly suppressed by NF-kappaB inhibitors (pyrrolidine dithiocarbamate, PDTC), IkappaBalpha phosphorylation inhibitors (Bay 117082) or IkappaB protease inhibitor (L-1-tosylamido-2-phenylethyl chloromethyl ketone, TPCK).	pyrrolidine dithiocarbamic acid	86-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
23604542-6	2013	Pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) or 2-deoxy-d-glucose (2-DG) (an inhibitor of glucose glycolysis) was applied 1 h before anaesthetic treatment.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-41
23603572-7	2013	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression in adipocytes.	pyrrolidine dithiocarbamic acid	33-60	CD40 molecule	Homo sapiens	107-111
23603572-7	2013	Importantly, NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) augmented the effect of fenofibrate on CD40 expression in adipocytes.	pyrrolidine dithiocarbamic acid	62-66	CD40 molecule	Homo sapiens	107-111
23604542-9	2013	Finally, pyrrolidine dithiocarbamate and 2-DG attenuated isoflurane-induced increases in IL-6 and NF-kappaB, and the transcription activity of NF-kappaB.	pyrrolidine dithiocarbamic acid	9-36	interleukin 6	Mus musculus	89-93
23604542-9	2013	Finally, pyrrolidine dithiocarbamate and 2-DG attenuated isoflurane-induced increases in IL-6 and NF-kappaB, and the transcription activity of NF-kappaB.	pyrrolidine dithiocarbamic acid	9-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
23604542-9	2013	Finally, pyrrolidine dithiocarbamate and 2-DG attenuated isoflurane-induced increases in IL-6 and NF-kappaB, and the transcription activity of NF-kappaB.	pyrrolidine dithiocarbamic acid	9-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
23089644-0	2013	Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats.	pyrrolidine dithiocarbamic acid	38-65	matrix metallopeptidase 9	Rattus norvegicus	99-104
23803522-0	2013	[Effects of pyrrolidine dithiocarbamate on expressions of alpha-smooth muscle actin, integrin alpha5 and fibronectin in acute paraquat poisoned rats].	pyrrolidine dithiocarbamic acid	12-39	actin gamma 2, smooth muscle	Rattus norvegicus	58-83
23627909-13	2013	The increase in CCL2 and CXCL1 expression by ET-1 was inhibited by actinomycin D, pyrrolidine dithiocarbamate, SN50, mithramycin, SB203580 and SP600125.	pyrrolidine dithiocarbamic acid	82-109	C-C motif chemokine ligand 2	Rattus norvegicus	16-20
23627909-13	2013	The increase in CCL2 and CXCL1 expression by ET-1 was inhibited by actinomycin D, pyrrolidine dithiocarbamate, SN50, mithramycin, SB203580 and SP600125.	pyrrolidine dithiocarbamic acid	82-109	C-X-C motif chemokine ligand 1	Rattus norvegicus	25-30
23627909-13	2013	The increase in CCL2 and CXCL1 expression by ET-1 was inhibited by actinomycin D, pyrrolidine dithiocarbamate, SN50, mithramycin, SB203580 and SP600125.	pyrrolidine dithiocarbamic acid	82-109	endothelin 1	Rattus norvegicus	45-49
23593564-6	2013	In vitro study showed that pyrrolidine dithiocarbamate treatment down-regulated levels of NF-kappaB and raised DNMT1 concentrations, confirming the effect of NF-kappaB/DNMT1 in the MCP-1 promoter DNA methylation process.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
23593564-6	2013	In vitro study showed that pyrrolidine dithiocarbamate treatment down-regulated levels of NF-kappaB and raised DNMT1 concentrations, confirming the effect of NF-kappaB/DNMT1 in the MCP-1 promoter DNA methylation process.	pyrrolidine dithiocarbamic acid	27-54	DNA methyltransferase (cytosine-5) 1	Mus musculus	111-116
23593564-6	2013	In vitro study showed that pyrrolidine dithiocarbamate treatment down-regulated levels of NF-kappaB and raised DNMT1 concentrations, confirming the effect of NF-kappaB/DNMT1 in the MCP-1 promoter DNA methylation process.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
23593564-6	2013	In vitro study showed that pyrrolidine dithiocarbamate treatment down-regulated levels of NF-kappaB and raised DNMT1 concentrations, confirming the effect of NF-kappaB/DNMT1 in the MCP-1 promoter DNA methylation process.	pyrrolidine dithiocarbamic acid	27-54	chemokine (C-C motif) ligand 2	Mus musculus	181-186
23395866-9	2013	High glucose (25 mM)-mediated vascular inflammation was blocked by PKC pseudosubstrate (PKC inhibitor 19-31) or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	136-163	nuclear factor kappa B subunit 1	Homo sapiens	116-125
23395866-9	2013	High glucose (25 mM)-mediated vascular inflammation was blocked by PKC pseudosubstrate (PKC inhibitor 19-31) or the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	165-169	nuclear factor kappa B subunit 1	Homo sapiens	116-125
23496811-8	2013	The indoxyl sulfate-induced downregulation of Nrf2 expression was alleviated by an inhibitor of nuclear factor-kappaB (NF-kappaB) (pyrrolidine dithiocarbamate) and small interfering RNA specific to NF-kappaB p65.	pyrrolidine dithiocarbamic acid	131-158	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50
23947625-3	2013	The effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and TLR3-neutralizing antibody on the expression of NF-kappaB, TNF-alpha, and IL-6 were investigated.	pyrrolidine dithiocarbamic acid	68-72	nuclear factor kappa B subunit 1	Homo sapiens	126-135
23947625-3	2013	The effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and TLR3-neutralizing antibody on the expression of NF-kappaB, TNF-alpha, and IL-6 were investigated.	pyrrolidine dithiocarbamic acid	68-72	interleukin 6	Homo sapiens	152-156
23947625-7	2013	Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	38-47
23947625-7	2013	Pyrrolidine dithiocarbamate inhibited NF-kappaB activation, resulting in the down-regulation of nuclear NF-kappaB protein, which led to the down-regulation of the mRNA and protein levels of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	104-113
23588388-9	2013	The treatment of OBs with SB203580 (an inhibitor of p38 MAPK) and pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-kappaB) prior to stimulation with SAS significantly inhibited the phosphorylation and mRNA expression of p38 MAPK and NF-kappaB p65, simultaneously reducing the release of MBD-14.	pyrrolidine dithiocarbamic acid	66-93	mitogen-activated protein kinase 14	Mus musculus	225-233
23566884-10	2013	Furthermore, the treatment of inhibitors specific for PI3K/Akt (LY294002), ERK (U0126), or NF-kappaB (pyrrolidine dithiocarbamate) to A549 cells reduced cell invasion and MMP-2/9 expression.	pyrrolidine dithiocarbamic acid	102-129	nuclear factor kappa B subunit 1	Homo sapiens	91-100
23566884-10	2013	Furthermore, the treatment of inhibitors specific for PI3K/Akt (LY294002), ERK (U0126), or NF-kappaB (pyrrolidine dithiocarbamate) to A549 cells reduced cell invasion and MMP-2/9 expression.	pyrrolidine dithiocarbamic acid	102-129	matrix metallopeptidase 2	Homo sapiens	171-178
23803522-0	2013	[Effects of pyrrolidine dithiocarbamate on expressions of alpha-smooth muscle actin, integrin alpha5 and fibronectin in acute paraquat poisoned rats].	pyrrolidine dithiocarbamic acid	12-39	fibronectin 1	Rattus norvegicus	105-116
23523950-9	2013	Finally, we found that trifluoperazine, a calmodulin inhibitor, and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor, attenuated the AVM-induced expression of P-gp, suggesting that AVM induces P-gp protein expression via the calmodulin/Relish (NF-kappaB) signaling pathway.	pyrrolidine dithiocarbamic acid	68-99	Relish	Drosophila melanogaster	104-113
23523950-9	2013	Finally, we found that trifluoperazine, a calmodulin inhibitor, and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor, attenuated the AVM-induced expression of P-gp, suggesting that AVM induces P-gp protein expression via the calmodulin/Relish (NF-kappaB) signaling pathway.	pyrrolidine dithiocarbamic acid	68-99	Multi drug resistance 65	Drosophila melanogaster	166-170
23523950-9	2013	Finally, we found that trifluoperazine, a calmodulin inhibitor, and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor, attenuated the AVM-induced expression of P-gp, suggesting that AVM induces P-gp protein expression via the calmodulin/Relish (NF-kappaB) signaling pathway.	pyrrolidine dithiocarbamic acid	68-99	Multi drug resistance 65	Drosophila melanogaster	200-204
23523950-9	2013	Finally, we found that trifluoperazine, a calmodulin inhibitor, and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor, attenuated the AVM-induced expression of P-gp, suggesting that AVM induces P-gp protein expression via the calmodulin/Relish (NF-kappaB) signaling pathway.	pyrrolidine dithiocarbamic acid	68-99	Relish	Drosophila melanogaster	243-249
23523950-9	2013	Finally, we found that trifluoperazine, a calmodulin inhibitor, and pyrrolidine dithiocarbamic acid, an NF-kappaB inhibitor, attenuated the AVM-induced expression of P-gp, suggesting that AVM induces P-gp protein expression via the calmodulin/Relish (NF-kappaB) signaling pathway.	pyrrolidine dithiocarbamic acid	68-99	Relish	Drosophila melanogaster	251-260
23404530-6	2013	In addition, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), and the AP-1 inhibitor, SP600125, decreased the protein levels of FN, collagen I and PAI-1, suggesting a role for the NF-kappaB and AP-1 pathways in the regulation of ECM accumulation induced by HG in RPMCs.	pyrrolidine dithiocarbamic acid	38-65	serpin family E member 1	Rattus norvegicus	159-164
23404530-6	2013	In addition, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), and the AP-1 inhibitor, SP600125, decreased the protein levels of FN, collagen I and PAI-1, suggesting a role for the NF-kappaB and AP-1 pathways in the regulation of ECM accumulation induced by HG in RPMCs.	pyrrolidine dithiocarbamic acid	38-65	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	206-210
23404530-6	2013	In addition, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), and the AP-1 inhibitor, SP600125, decreased the protein levels of FN, collagen I and PAI-1, suggesting a role for the NF-kappaB and AP-1 pathways in the regulation of ECM accumulation induced by HG in RPMCs.	pyrrolidine dithiocarbamic acid	67-71	serpin family E member 1	Rattus norvegicus	159-164
23404530-6	2013	In addition, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), and the AP-1 inhibitor, SP600125, decreased the protein levels of FN, collagen I and PAI-1, suggesting a role for the NF-kappaB and AP-1 pathways in the regulation of ECM accumulation induced by HG in RPMCs.	pyrrolidine dithiocarbamic acid	67-71	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	206-210
23151670-1	2013	The aim of the present study was to investigate the effect of the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), on high-mobility group protein B1 (HMGB1) expression in a rat model of chronic obstructive pulmonary disease (COPD).	pyrrolidine dithiocarbamic acid	111-138	high mobility group box 1	Rattus norvegicus	150-180
23230847-10	2013	Additionally, intrathecal injection of the p65 antagonist pyrrolidine dithiocarbamate attenuated mechanical allodynia and markedly inhibited CBS expression in DRGs in STZ rats.	pyrrolidine dithiocarbamic acid	58-85	synaptotagmin 1	Rattus norvegicus	43-46
23230847-10	2013	Additionally, intrathecal injection of the p65 antagonist pyrrolidine dithiocarbamate attenuated mechanical allodynia and markedly inhibited CBS expression in DRGs in STZ rats.	pyrrolidine dithiocarbamic acid	58-85	cystathionine beta synthase	Rattus norvegicus	141-144
23151670-1	2013	The aim of the present study was to investigate the effect of the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), on high-mobility group protein B1 (HMGB1) expression in a rat model of chronic obstructive pulmonary disease (COPD).	pyrrolidine dithiocarbamic acid	111-138	high mobility group box 1	Rattus norvegicus	182-187
23151670-1	2013	The aim of the present study was to investigate the effect of the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), on high-mobility group protein B1 (HMGB1) expression in a rat model of chronic obstructive pulmonary disease (COPD).	pyrrolidine dithiocarbamic acid	140-144	high mobility group box 1	Rattus norvegicus	150-180
23151670-1	2013	The aim of the present study was to investigate the effect of the nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidine dithiocarbamate (PDTC), on high-mobility group protein B1 (HMGB1) expression in a rat model of chronic obstructive pulmonary disease (COPD).	pyrrolidine dithiocarbamic acid	140-144	high mobility group box 1	Rattus norvegicus	182-187
24021937-14	2013	Furthermore, pyrrolidine dithiocarbamate abolished Ang II-induced CRP expression.	pyrrolidine dithiocarbamic acid	13-40	angiotensinogen	Homo sapiens	51-57
23372364-4	2013	We blocked SGC7901 cells with pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of nuclear factor kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	30-57	nuclear factor kappa B subunit 1	Homo sapiens	113-122
23372364-4	2013	We blocked SGC7901 cells with pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of nuclear factor kappaB (NF-kappaB).	pyrrolidine dithiocarbamic acid	59-63	nuclear factor kappa B subunit 1	Homo sapiens	113-122
24021937-14	2013	Furthermore, pyrrolidine dithiocarbamate abolished Ang II-induced CRP expression.	pyrrolidine dithiocarbamic acid	13-40	C-reactive protein	Homo sapiens	66-69
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	tumor necrosis factor	Mus musculus	185-194
24078775-3	2013	Pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF- kappa B) and goat anti-human IL-6 polyclonal neutralizing antibody were used to inhibit NF- kappa B activation and IL-6 production, respectively.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	161-172
24078775-3	2013	Pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF- kappa B) and goat anti-human IL-6 polyclonal neutralizing antibody were used to inhibit NF- kappa B activation and IL-6 production, respectively.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	188-192
24078775-3	2013	Pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF- kappa B) and goat anti-human IL-6 polyclonal neutralizing antibody were used to inhibit NF- kappa B activation and IL-6 production, respectively.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	161-172
23128665-11	2013	Furthermore, the increased levels of MDA in the conditioned medium and the decrease in the total SOD activity caused by the AngII treatment were reversed by treatment with probucol or PDTC.	pyrrolidine dithiocarbamic acid	184-188	superoxide dismutase 1	Homo sapiens	97-100
23128665-11	2013	Furthermore, the increased levels of MDA in the conditioned medium and the decrease in the total SOD activity caused by the AngII treatment were reversed by treatment with probucol or PDTC.	pyrrolidine dithiocarbamic acid	184-188	angiotensinogen	Homo sapiens	124-129
22983620-9	2013	On the other hand, an inhibitor of nuclear factor kappaB (NF-kappaB), ammonium pyrrolidine-1-carbodithioate, suppressed the DA-induced expression of EC-SOD mRNA.	pyrrolidine dithiocarbamic acid	70-107	superoxide dismutase 3	Rattus norvegicus	149-155
23255946-10	2013	Using a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate, it was confirmed that TNF-alpha-induced MMP-9 gene expression is primarily regulated by NF-kappaB activation.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	17-26
23255946-10	2013	Using a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate, it was confirmed that TNF-alpha-induced MMP-9 gene expression is primarily regulated by NF-kappaB activation.	pyrrolidine dithiocarbamic acid	38-65	tumor necrosis factor	Homo sapiens	89-98
23255946-10	2013	Using a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate, it was confirmed that TNF-alpha-induced MMP-9 gene expression is primarily regulated by NF-kappaB activation.	pyrrolidine dithiocarbamic acid	38-65	matrix metallopeptidase 9	Homo sapiens	107-112
23255946-10	2013	Using a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate, it was confirmed that TNF-alpha-induced MMP-9 gene expression is primarily regulated by NF-kappaB activation.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	155-164
23433149-0	2013	[Intervention of pyrrolidine dithiocarbamate on expressions of connective tissue growth factor, type I collagen, and type III collage in acute paraquat poisoned rats].	pyrrolidine dithiocarbamic acid	17-44	cellular communication network factor 2	Rattus norvegicus	63-94
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	interleukin 1 beta	Mus musculus	196-204
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	interleukin 6	Mus musculus	206-210
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	interferon gamma	Mus musculus	215-224
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	tumor necrosis factor	Mus musculus	185-194
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	interleukin 1 beta	Mus musculus	196-204
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	interleukin 6	Mus musculus	206-210
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	interferon gamma	Mus musculus	215-224
23341882-3	2013	Pyrrolidine dithiocarbamate (PDTC) and a TNFR1 blocking peptide (TNFR1BP) significantly inhibited LPS-induced MMP9 expression in A549 cells (p&lt;0.05).	pyrrolidine dithiocarbamic acid	0-27	matrix metallopeptidase 9	Homo sapiens	110-114
23341882-3	2013	Pyrrolidine dithiocarbamate (PDTC) and a TNFR1 blocking peptide (TNFR1BP) significantly inhibited LPS-induced MMP9 expression in A549 cells (p&lt;0.05).	pyrrolidine dithiocarbamic acid	29-33	matrix metallopeptidase 9	Homo sapiens	110-114
23547889-10	2013	The effect was reversed by treatment with the PI3K inhibitor LY2940042 (LY) and the nuclear factor kappa B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	129-156	nuclear factor kappa B subunit 1	Homo sapiens	84-106
23547889-10	2013	The effect was reversed by treatment with the PI3K inhibitor LY2940042 (LY) and the nuclear factor kappa B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	129-156	nuclear factor kappa B subunit 1	Homo sapiens	108-117
23547889-10	2013	The effect was reversed by treatment with the PI3K inhibitor LY2940042 (LY) and the nuclear factor kappa B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	158-162	nuclear factor kappa B subunit 1	Homo sapiens	84-106
23547889-10	2013	The effect was reversed by treatment with the PI3K inhibitor LY2940042 (LY) and the nuclear factor kappa B (NF-kappaB) inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	158-162	nuclear factor kappa B subunit 1	Homo sapiens	108-117
23600205-6	2013	RESULTS: When SiHa cells were pretreated with aspirin, sulindac, curcumin or PDTC, Western blot showed that the expression of P65 was inhibited upon cisplatin stimulus (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	77-81	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
23600205-10	2013	CONCLUSION: Aspirin, sulindac, curcumin and PDTC could all inhibit cisplatin induced NF-kappaB activiation, which could increase cispaltin-induced chemosensativity by augments of apoptosis.	pyrrolidine dithiocarbamic acid	44-48	nuclear factor kappa B subunit 1	Homo sapiens	85-94
22738794-8	2013	Ammonium pyrrolidinedithiocarbamate(PDCT) inhibited compressive force-induced NF-kappaB activity in EMSA.	pyrrolidine dithiocarbamic acid	0-35	nuclear factor kappa B subunit 1	Homo sapiens	78-87
22974838-5	2012	A specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated the LPS-induced expression of iNOS, COX-2 and TNF-alpha genes.	pyrrolidine dithiocarbamic acid	32-59	nitric oxide synthase 2, inducible	Mus musculus	109-113
22974838-5	2012	A specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated the LPS-induced expression of iNOS, COX-2 and TNF-alpha genes.	pyrrolidine dithiocarbamic acid	32-59	tumor necrosis factor	Mus musculus	125-134
22974838-5	2012	A specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated the LPS-induced expression of iNOS, COX-2 and TNF-alpha genes.	pyrrolidine dithiocarbamic acid	61-65	nitric oxide synthase 2, inducible	Mus musculus	109-113
22974838-5	2012	A specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), attenuated the LPS-induced expression of iNOS, COX-2 and TNF-alpha genes.	pyrrolidine dithiocarbamic acid	61-65	tumor necrosis factor	Mus musculus	125-134
22972875-9	2012	Pyrrolidine dithiocarbamate inhibited nuclear localization of NF-kappaBp65 and subsequent downregulation of the transcription and secretion of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	143-152
22972875-9	2012	Pyrrolidine dithiocarbamate inhibited nuclear localization of NF-kappaBp65 and subsequent downregulation of the transcription and secretion of TNF-alpha and IL-6.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Rattus norvegicus	157-161
23289322-5	2012	L. plantarum NDC 75017 could rapidly activate the phosphorylation of NF-kappaB, and the expressions of il-6 and tlr2 were decreased notably after pretreated with pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	162-189	interleukin 6	Homo sapiens	103-107
22569294-7	2012	In addition, pyrrolidine-dithiocarbamate completely suppressed not only NF-kappaB activation but also renal dysfunction and ET-1 overproduction.	pyrrolidine dithiocarbamic acid	13-40	endothelin 1	Rattus norvegicus	124-128
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-235	interleukin 2	Homo sapiens	24-37
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-235	interleukin 2	Homo sapiens	39-43
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-235	MX dynamin like GTPase 1	Homo sapiens	46-82
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-235	nuclear factor kappa B subunit 1	Homo sapiens	144-165
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	208-235	nuclear factor kappa B subunit 1	Homo sapiens	167-176
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	237-241	interleukin 2	Homo sapiens	24-37
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	237-241	interleukin 2	Homo sapiens	39-43
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	237-241	MX dynamin like GTPase 1	Homo sapiens	46-82
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	237-241	nuclear factor kappa B subunit 1	Homo sapiens	144-165
22940568-3	2012	The mRNA expressions of interleukin-2 (IL-2), gamma interferon (INF-gamma) and MxA were up-regulated by MPL treatments, but down-regulated when nuclear factor-kappaB (NF-kappaB) signal pathway was blocked by pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	237-241	nuclear factor kappa B subunit 1	Homo sapiens	167-176
23289322-5	2012	L. plantarum NDC 75017 could rapidly activate the phosphorylation of NF-kappaB, and the expressions of il-6 and tlr2 were decreased notably after pretreated with pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	162-189	toll like receptor 2	Homo sapiens	112-116
22587999-9	2012	The NF-kappaB inhibitor, "pyrrolidine dithiocarbamate" partially suppressed the RU486-induced endometrial breakdown, thus verifying the role of this pathway in vivo.	pyrrolidine dithiocarbamic acid	26-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	4-13
22555979-6	2012	Additionally, after stimulation of cell with ammonium pyrrolidine dithiocarbamate, cell proliferation and collagen synthesis induced by NF-kB and the upregulation of MMP-9 production were inhibited.	pyrrolidine dithiocarbamic acid	45-81	nuclear factor kappa B subunit 1	Rattus norvegicus	136-141
22555979-6	2012	Additionally, after stimulation of cell with ammonium pyrrolidine dithiocarbamate, cell proliferation and collagen synthesis induced by NF-kB and the upregulation of MMP-9 production were inhibited.	pyrrolidine dithiocarbamic acid	45-81	matrix metallopeptidase 9	Rattus norvegicus	166-171
23170132-1	2012	This study aimed to investigate the impact of the combined use of the nuclear factor-kappaB (NF-kappaB) inhibitors pyrrolidine dithiocarbamate (PDTC), bortezomib or SN50, and the chemotherapy agents arsenic acid (As(2)O(3)), fluorouracil (5FU), oxaliplatin or paclitaxel on the growth and apoptosis of HT-29 cells.	pyrrolidine dithiocarbamic acid	115-142	nuclear factor kappa B subunit 1	Homo sapiens	70-91
23170132-1	2012	This study aimed to investigate the impact of the combined use of the nuclear factor-kappaB (NF-kappaB) inhibitors pyrrolidine dithiocarbamate (PDTC), bortezomib or SN50, and the chemotherapy agents arsenic acid (As(2)O(3)), fluorouracil (5FU), oxaliplatin or paclitaxel on the growth and apoptosis of HT-29 cells.	pyrrolidine dithiocarbamic acid	115-142	nuclear factor kappa B subunit 1	Homo sapiens	93-102
22842850-8	2012	Notably, upon blocking the NF-kappaB binding with             pyrrolidine dithiocarbamate, it was demonstrated that the expression of MMP-9             by LPS occurs through TLR4/NF-kappaB pathways.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	27-36
22842850-8	2012	Notably, upon blocking the NF-kappaB binding with             pyrrolidine dithiocarbamate, it was demonstrated that the expression of MMP-9             by LPS occurs through TLR4/NF-kappaB pathways.	pyrrolidine dithiocarbamic acid	62-89	matrix metallopeptidase 9	Homo sapiens	134-139
22842850-8	2012	Notably, upon blocking the NF-kappaB binding with             pyrrolidine dithiocarbamate, it was demonstrated that the expression of MMP-9             by LPS occurs through TLR4/NF-kappaB pathways.	pyrrolidine dithiocarbamic acid	62-89	toll like receptor 4	Homo sapiens	174-178
22842850-8	2012	Notably, upon blocking the NF-kappaB binding with             pyrrolidine dithiocarbamate, it was demonstrated that the expression of MMP-9             by LPS occurs through TLR4/NF-kappaB pathways.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	179-188
22404622-5	2012	Furthermore, pyrrolidine dithiocarbamate, a NF-kappaB-specific inhibitor, at 10mum displayed anti-migration and invasion effects and inhibition of MMP 2 and MMP 9 expression resembling that of melatonin.	pyrrolidine dithiocarbamic acid	13-40	matrix metallopeptidase 2	Homo sapiens	147-152
22404622-5	2012	Furthermore, pyrrolidine dithiocarbamate, a NF-kappaB-specific inhibitor, at 10mum displayed anti-migration and invasion effects and inhibition of MMP 2 and MMP 9 expression resembling that of melatonin.	pyrrolidine dithiocarbamic acid	13-40	matrix metallopeptidase 9	Homo sapiens	157-162
22677363-5	2012	In cultured murine macrophages, oxLDL induced LOX-1 expression at the mRNA and protein levels, was abrogated by addition of Tan or pyrrolidinedithiocarbamic acid ammonium salt (PDTC), a widely used inhibitor of NF-kappaB, suggesting the involvement of NF-kappaB.	pyrrolidine dithiocarbamic acid	131-175	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	46-51
22677363-5	2012	In cultured murine macrophages, oxLDL induced LOX-1 expression at the mRNA and protein levels, was abrogated by addition of Tan or pyrrolidinedithiocarbamic acid ammonium salt (PDTC), a widely used inhibitor of NF-kappaB, suggesting the involvement of NF-kappaB.	pyrrolidine dithiocarbamic acid	131-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	211-220
22677363-5	2012	In cultured murine macrophages, oxLDL induced LOX-1 expression at the mRNA and protein levels, was abrogated by addition of Tan or pyrrolidinedithiocarbamic acid ammonium salt (PDTC), a widely used inhibitor of NF-kappaB, suggesting the involvement of NF-kappaB.	pyrrolidine dithiocarbamic acid	131-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	252-261
22318993-5	2012	Treatment of 0-copy mice with NF-kappaB inhibitors andrographolide, pyrrolidine dithiocarbamate, and etanercept showed a substantial reduction in renal fibrosis, attenuation of proinflammatory cytokines gene expression, and significantly reduced IKK activity and IkBalpha phosphorylation.	pyrrolidine dithiocarbamic acid	68-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	30-57	nuclear factor kappa B subunit 1	Homo sapiens	82-91
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	30-57	nuclear factor kappa B subunit 1	Homo sapiens	168-177
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	59-63	nuclear factor kappa B subunit 1	Homo sapiens	82-91
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	pyrrolidine dithiocarbamic acid	59-63	nuclear factor kappa B subunit 1	Homo sapiens	168-177
22529688-6	2012	Interestingly, application of the NF-kappaB specific inhibitor, pyrrolidinedithiocarbamate (PDTC), to SGC-7901 cells significantly potentized the toxicarioside A-induced down-regulation of bFGF compared with the control group (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	64-90	nuclear factor kappa B subunit 1	Homo sapiens	34-43
22529688-6	2012	Interestingly, application of the NF-kappaB specific inhibitor, pyrrolidinedithiocarbamate (PDTC), to SGC-7901 cells significantly potentized the toxicarioside A-induced down-regulation of bFGF compared with the control group (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	64-90	fibroblast growth factor 2	Homo sapiens	189-193
22529688-6	2012	Interestingly, application of the NF-kappaB specific inhibitor, pyrrolidinedithiocarbamate (PDTC), to SGC-7901 cells significantly potentized the toxicarioside A-induced down-regulation of bFGF compared with the control group (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	92-96	nuclear factor kappa B subunit 1	Homo sapiens	34-43
22529688-6	2012	Interestingly, application of the NF-kappaB specific inhibitor, pyrrolidinedithiocarbamate (PDTC), to SGC-7901 cells significantly potentized the toxicarioside A-induced down-regulation of bFGF compared with the control group (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	92-96	fibroblast growth factor 2	Homo sapiens	189-193
22617452-6	2012	Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression.	pyrrolidine dithiocarbamic acid	66-93	fibroblast growth factor 2	Mus musculus	135-140
22617452-6	2012	Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression.	pyrrolidine dithiocarbamic acid	66-93	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	163-170
22617452-6	2012	Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression.	pyrrolidine dithiocarbamic acid	66-93	BCL2-like 1	Mus musculus	175-181
22288713-7	2012	Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6).	pyrrolidine dithiocarbamic acid	36-63	nuclear factor kappa B subunit 1	Homo sapiens	113-122
22288713-7	2012	Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6).	pyrrolidine dithiocarbamic acid	36-63	tumor necrosis factor	Homo sapiens	130-138
22288713-7	2012	Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6).	pyrrolidine dithiocarbamic acid	36-63	interleukin 6	Homo sapiens	174-178
22288713-7	2012	Both the NF-kappaB inhibitor, PDTC (pyrrolidine dithiocarbamate) and TLR4 knockdown could block LPS induction of NF-kappaB, STIM, TNFalpha (tumour necrosis factor alpha) and IL-6 (interleukin 6).	pyrrolidine dithiocarbamic acid	36-63	interleukin 6	Homo sapiens	180-193
22252121-7	2012	The JunB levels were decreased by the treatment with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	77-104	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
22314292-5	2012	Of interest, infection with BioKnife strongly facilitated the uPA release from H226 cells, and this effect was completely abolished by use of either pyrrolidine dithiocarbamate (PDTC) or BioKnife expressing the C-terminus-deleted dominant negative inhibitor for retinoic acid-inducible gene-I (RIG-IC), indicating that BioKnife-dependent expression of uPA was mediated by the RIG-I/nuclear factor-kappaB (NF-kappaB) axis, detecting RNA viral genome replication.	pyrrolidine dithiocarbamic acid	149-176	plasminogen activator, urokinase	Homo sapiens	62-65
22314292-5	2012	Of interest, infection with BioKnife strongly facilitated the uPA release from H226 cells, and this effect was completely abolished by use of either pyrrolidine dithiocarbamate (PDTC) or BioKnife expressing the C-terminus-deleted dominant negative inhibitor for retinoic acid-inducible gene-I (RIG-IC), indicating that BioKnife-dependent expression of uPA was mediated by the RIG-I/nuclear factor-kappaB (NF-kappaB) axis, detecting RNA viral genome replication.	pyrrolidine dithiocarbamic acid	149-176	plasminogen activator, urokinase	Homo sapiens	352-355
22314292-5	2012	Of interest, infection with BioKnife strongly facilitated the uPA release from H226 cells, and this effect was completely abolished by use of either pyrrolidine dithiocarbamate (PDTC) or BioKnife expressing the C-terminus-deleted dominant negative inhibitor for retinoic acid-inducible gene-I (RIG-IC), indicating that BioKnife-dependent expression of uPA was mediated by the RIG-I/nuclear factor-kappaB (NF-kappaB) axis, detecting RNA viral genome replication.	pyrrolidine dithiocarbamic acid	149-176	nuclear factor kappa B subunit 1	Homo sapiens	376-403
22314292-5	2012	Of interest, infection with BioKnife strongly facilitated the uPA release from H226 cells, and this effect was completely abolished by use of either pyrrolidine dithiocarbamate (PDTC) or BioKnife expressing the C-terminus-deleted dominant negative inhibitor for retinoic acid-inducible gene-I (RIG-IC), indicating that BioKnife-dependent expression of uPA was mediated by the RIG-I/nuclear factor-kappaB (NF-kappaB) axis, detecting RNA viral genome replication.	pyrrolidine dithiocarbamic acid	149-176	nuclear factor kappa B subunit 1	Homo sapiens	405-414
21926933-8	2012	Inhibition of the NF-kappaB signal axis with pyrrolidine dithiocarbamate reduced serum amylase, blocked pancreatic NF-kappaB activation, and reduced the levels of LC3-II and beclin 1.	pyrrolidine dithiocarbamic acid	45-72	annexin A3	Rattus norvegicus	163-166
21926933-8	2012	Inhibition of the NF-kappaB signal axis with pyrrolidine dithiocarbamate reduced serum amylase, blocked pancreatic NF-kappaB activation, and reduced the levels of LC3-II and beclin 1.	pyrrolidine dithiocarbamic acid	45-72	beclin 1	Rattus norvegicus	174-182
22252121-7	2012	The JunB levels were decreased by the treatment with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	77-104	nuclear factor kappa B subunit 1	Homo sapiens	56-65
21483233-8	2012	Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate impairs TNF-alpha-induced PTP-1B upregulation.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	14-23
22139526-8	2012	However, the presence of pyridoxamine (an AGEs inhibitor) and pyrrolidine dithiocarbamate (a NF-kappaB inhibitor) prevented apoptosis in HLE-B3 cells through the inhibition of argpyrimidine formation and the blockage of NF-kappaB nuclear translocalization, respectively.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	93-102
22139526-8	2012	However, the presence of pyridoxamine (an AGEs inhibitor) and pyrrolidine dithiocarbamate (a NF-kappaB inhibitor) prevented apoptosis in HLE-B3 cells through the inhibition of argpyrimidine formation and the blockage of NF-kappaB nuclear translocalization, respectively.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	220-229
22127228-0	2012	Pyrrolidine dithiocarbamate enhances hepatic glycogen synthesis and reduces FoxO1-mediated gene transcription in type 2 diabetic rats.	pyrrolidine dithiocarbamic acid	0-27	forkhead box O1	Rattus norvegicus	76-81
22127228-1	2012	The aim of the present study was to examine the effects of pyrrolidine dithiocarbamate (PDTC) on hepatic glycogen synthesis and FoxO1 transcriptional activity in type 2 diabetic rats and the mechanism underlying these effects.	pyrrolidine dithiocarbamic acid	59-86	forkhead box O1	Rattus norvegicus	128-133
22085843-0	2012	Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic beta-cells.	pyrrolidine dithiocarbamic acid	73-100	Eph receptor B1	Rattus norvegicus	40-43
22085843-0	2012	Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic beta-cells.	pyrrolidine dithiocarbamic acid	73-100	mitogen-activated protein kinase 8	Rattus norvegicus	44-47
22085843-7	2012	Cu(2+)/PDTC complex could also increase the LPO and decrease the intracellular reduced GSH levels, and display several features of apoptosis signals including: increase in sub-G1 cell population, annexin-V binding, and caspase-3 activity, mitochondrial dysfunctions, and the activation of PARP and caspase cascades, which accompanied with the marked increase the intracellular Cu(2+) levels.	pyrrolidine dithiocarbamic acid	7-11	lactoperoxidase	Rattus norvegicus	44-47
22085843-7	2012	Cu(2+)/PDTC complex could also increase the LPO and decrease the intracellular reduced GSH levels, and display several features of apoptosis signals including: increase in sub-G1 cell population, annexin-V binding, and caspase-3 activity, mitochondrial dysfunctions, and the activation of PARP and caspase cascades, which accompanied with the marked increase the intracellular Cu(2+) levels.	pyrrolidine dithiocarbamic acid	7-11	annexin A5	Rattus norvegicus	196-205
22085843-7	2012	Cu(2+)/PDTC complex could also increase the LPO and decrease the intracellular reduced GSH levels, and display several features of apoptosis signals including: increase in sub-G1 cell population, annexin-V binding, and caspase-3 activity, mitochondrial dysfunctions, and the activation of PARP and caspase cascades, which accompanied with the marked increase the intracellular Cu(2+) levels.	pyrrolidine dithiocarbamic acid	7-11	caspase 3	Rattus norvegicus	219-228
22085843-9	2012	Furthermore, Cu(2+)/PDTC complex was capable of increasing the phosphorylations of ERK1/2 and JNK, and its upstream kinase MEK1/2 and MKK4, which could be reversed by NAC.	pyrrolidine dithiocarbamic acid	20-24	mitogen activated protein kinase 3	Rattus norvegicus	83-89
22085843-9	2012	Furthermore, Cu(2+)/PDTC complex was capable of increasing the phosphorylations of ERK1/2 and JNK, and its upstream kinase MEK1/2 and MKK4, which could be reversed by NAC.	pyrrolidine dithiocarbamic acid	20-24	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
22085843-9	2012	Furthermore, Cu(2+)/PDTC complex was capable of increasing the phosphorylations of ERK1/2 and JNK, and its upstream kinase MEK1/2 and MKK4, which could be reversed by NAC.	pyrrolidine dithiocarbamic acid	20-24	mitogen activated protein kinase kinase 1	Rattus norvegicus	123-129
22085843-9	2012	Furthermore, Cu(2+)/PDTC complex was capable of increasing the phosphorylations of ERK1/2 and JNK, and its upstream kinase MEK1/2 and MKK4, which could be reversed by NAC.	pyrrolidine dithiocarbamic acid	20-24	mitogen activated protein kinase kinase 4	Rattus norvegicus	134-138
21960547-7	2012	The NF-kappaB inhibitor pyrrolidine dithiocarbamate attenuated SWCNT-induced airway hyperreactivity, chronic airway inflammation, and MMP12 and cathepsin K expression when administered in vivo, whereas a cathepsin K inhibitor could partially reduce airway hyperreactivity and granulomatous changes in the SWCNT-treated group.	pyrrolidine dithiocarbamic acid	24-51	matrix metallopeptidase 12	Mus musculus	134-139
21960547-7	2012	The NF-kappaB inhibitor pyrrolidine dithiocarbamate attenuated SWCNT-induced airway hyperreactivity, chronic airway inflammation, and MMP12 and cathepsin K expression when administered in vivo, whereas a cathepsin K inhibitor could partially reduce airway hyperreactivity and granulomatous changes in the SWCNT-treated group.	pyrrolidine dithiocarbamic acid	24-51	cathepsin K	Mus musculus	144-155
21698451-4	2012	METHODS: SKOV3 cells were treated with different concentrations of EGCG and the NF-kappaB-specific inhibitor pyrrolidine dithiocarbamate (PDTC) for different times.	pyrrolidine dithiocarbamic acid	109-136	nuclear factor kappa B subunit 1	Homo sapiens	80-89
21698451-4	2012	METHODS: SKOV3 cells were treated with different concentrations of EGCG and the NF-kappaB-specific inhibitor pyrrolidine dithiocarbamate (PDTC) for different times.	pyrrolidine dithiocarbamic acid	138-142	nuclear factor kappa B subunit 1	Homo sapiens	80-89
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	196-223	nuclear factor kappa B subunit 1	Homo sapiens	32-41
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	196-223	NDRG family member 2	Homo sapiens	92-97
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	196-223	nuclear factor kappa B subunit 1	Homo sapiens	176-185
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	225-229	nuclear factor kappa B subunit 1	Homo sapiens	32-41
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	225-229	NDRG family member 2	Homo sapiens	92-97
22138128-7	2012	Meanwhile, transcription factor NF-kappaB was activated by EDS administration, bound to the ndrg2 promoter, and further increased in expression, effects that were abolished by NF-kappaB inhibitor Pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	225-229	nuclear factor kappa B subunit 1	Homo sapiens	176-185
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	118-145	nuclear factor kappa B subunit 1	Homo sapiens	4-26
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	118-145	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	118-145	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	147-151	nuclear factor kappa B subunit 1	Homo sapiens	4-26
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	147-151	nuclear factor kappa B subunit 1	Homo sapiens	28-37
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	147-151	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22020376-7	2012	(c) Nuclear factor Kappa B (NF-kappaB) was activated following exposure to DEDC, and suppressing NF-kappaB pathway by pyrrolidine dithiocarbamate (PDTC, a potent NF-kappaB inhibitor) significantly increased neuroblastoma cell sensitivity to the pro-apoptotic effect of DEDC.	pyrrolidine dithiocarbamic acid	147-151	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22508044-5	2012	Pyrrolidine dithiocarbamate (PDTC) was used as a selective NFkappa-B inhibitor to clarify the relationship between PARG, PARP and NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	poly (ADP-ribose) glycohydrolase	Mus musculus	115-119
22508044-5	2012	Pyrrolidine dithiocarbamate (PDTC) was used as a selective NFkappa-B inhibitor to clarify the relationship between PARG, PARP and NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	poly (ADP-ribose) polymerase family, member 1	Mus musculus	121-125
22508044-5	2012	Pyrrolidine dithiocarbamate (PDTC) was used as a selective NFkappa-B inhibitor to clarify the relationship between PARG, PARP and NF-kappaB.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
22064360-6	2012	DTF suppressed NF-kappaB activation, and addition of NF-kappaB inhibitor, pyrrolidine dithiocarbamate or Bay 11-7082, synergistically enhanced DTF-mediated HO-1 expression, indicating that HO-1 induction is associated with NF-kappaB suppression.	pyrrolidine dithiocarbamic acid	74-101	heme oxygenase 1	Rattus norvegicus	189-193
23281704-5	2012	Treatment of the cells with p38 inhibitor SB203580 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) showed that p38 functioned upstream of NF-kappaB, while augmented apoptosis and cell cycle arrest were induced in response to NCTD with NF-kappaB activation.	pyrrolidine dithiocarbamic acid	75-102	nuclear factor kappa B subunit 1	Homo sapiens	55-64
23281704-5	2012	Treatment of the cells with p38 inhibitor SB203580 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) showed that p38 functioned upstream of NF-kappaB, while augmented apoptosis and cell cycle arrest were induced in response to NCTD with NF-kappaB activation.	pyrrolidine dithiocarbamic acid	75-102	mitogen-activated protein kinase 14	Homo sapiens	122-125
23281704-5	2012	Treatment of the cells with p38 inhibitor SB203580 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) showed that p38 functioned upstream of NF-kappaB, while augmented apoptosis and cell cycle arrest were induced in response to NCTD with NF-kappaB activation.	pyrrolidine dithiocarbamic acid	75-102	nuclear factor kappa B subunit 1	Homo sapiens	149-158
23281704-5	2012	Treatment of the cells with p38 inhibitor SB203580 and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) showed that p38 functioned upstream of NF-kappaB, while augmented apoptosis and cell cycle arrest were induced in response to NCTD with NF-kappaB activation.	pyrrolidine dithiocarbamic acid	75-102	nuclear factor kappa B subunit 1	Homo sapiens	149-158
22419429-6	2012	Treatment with NF-kappaB inhibitors, pyrrolidine dithiocarbamate, and BAY 11-7082 significantly attenuated GP50E-induced PON1 production and NF-kappaB transactivation activity.	pyrrolidine dithiocarbamic acid	37-64	paraoxonase 1	Homo sapiens	121-125
22419429-6	2012	Treatment with NF-kappaB inhibitors, pyrrolidine dithiocarbamate, and BAY 11-7082 significantly attenuated GP50E-induced PON1 production and NF-kappaB transactivation activity.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor kappa B subunit 1	Homo sapiens	141-150
21733316-8	2012	Furthermore, pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, attenuated the production of pro-inflammatory mediators except for IL-6 in PA-stimulated microglia.	pyrrolidine dithiocarbamic acid	13-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
22613992-13	2012	Tryptase also activated NF-kappa B within 30 min, and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF- kappa B, reduced tryptase-induced TNF-alpha and IL-6 release.	pyrrolidine dithiocarbamic acid	54-89	nuclear factor kappa B subunit 1	Homo sapiens	107-118
22613992-13	2012	Tryptase also activated NF-kappa B within 30 min, and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF- kappa B, reduced tryptase-induced TNF-alpha and IL-6 release.	pyrrolidine dithiocarbamic acid	54-89	tumor necrosis factor	Homo sapiens	145-154
22613992-13	2012	Tryptase also activated NF-kappa B within 30 min, and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF- kappa B, reduced tryptase-induced TNF-alpha and IL-6 release.	pyrrolidine dithiocarbamic acid	54-89	interleukin 6	Homo sapiens	159-163
22832115-7	2012	Activating protein (AP-1) and nuclear factor kappa B (NF-kB) transcription factor inhibitors, curcumin and pyrrolidine dithiocarbamate (PDTC) partially inhibited ADAMTS-4 induction and activity.	pyrrolidine dithiocarbamic acid	107-134	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	162-170
22832115-7	2012	Activating protein (AP-1) and nuclear factor kappa B (NF-kB) transcription factor inhibitors, curcumin and pyrrolidine dithiocarbamate (PDTC) partially inhibited ADAMTS-4 induction and activity.	pyrrolidine dithiocarbamic acid	136-140	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	162-170
22064360-6	2012	DTF suppressed NF-kappaB activation, and addition of NF-kappaB inhibitor, pyrrolidine dithiocarbamate or Bay 11-7082, synergistically enhanced DTF-mediated HO-1 expression, indicating that HO-1 induction is associated with NF-kappaB suppression.	pyrrolidine dithiocarbamic acid	74-101	heme oxygenase 1	Rattus norvegicus	156-160
21483233-8	2012	Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate impairs TNF-alpha-induced PTP-1B upregulation.	pyrrolidine dithiocarbamic acid	38-65	tumor necrosis factor	Homo sapiens	74-83
21483233-8	2012	Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate impairs TNF-alpha-induced PTP-1B upregulation.	pyrrolidine dithiocarbamic acid	38-65	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	92-98
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	51-78	nuclear factor kappa B subunit 1	Homo sapiens	38-47
23221158-6	2012	The expression of uPA mRNA and PA secretion stimulated by TNF-alpha were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrrolidine dithiocarbamate, but were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	pyrrolidine dithiocarbamic acid	173-200	plasminogen activator, urokinase	Homo sapiens	18-21
23221158-6	2012	The expression of uPA mRNA and PA secretion stimulated by TNF-alpha were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrrolidine dithiocarbamate, but were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	pyrrolidine dithiocarbamic acid	173-200	tumor necrosis factor	Homo sapiens	58-67
23221158-6	2012	The expression of uPA mRNA and PA secretion stimulated by TNF-alpha were reduced by the tyrosine kinase inhibitors herbimycin A and genistein, and by the NFkappaB inhibitor pyrrolidine dithiocarbamate, but were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate.	pyrrolidine dithiocarbamic acid	173-200	nuclear factor kappa B subunit 1	Homo sapiens	154-162
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	51-78	nuclear factor kappa B subunit 1	Homo sapiens	120-129
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	51-78	zinc finger protein 580	Homo sapiens	180-186
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	80-84	nuclear factor kappa B subunit 1	Homo sapiens	38-47
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	80-84	nuclear factor kappa B subunit 1	Homo sapiens	120-129
21830064-6	2012	In subsequent research, inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC, a selective chemical inhibitor of NF-kappaB) was shown to block the upregulated expression of ZNF580 that was induced by H2O2.	pyrrolidine dithiocarbamic acid	80-84	zinc finger protein 580	Homo sapiens	180-186
21917559-0	2011	Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation.	pyrrolidine dithiocarbamic acid	10-37	mechanistic target of rapamycin kinase	Homo sapiens	59-88
22004609-7	2011	Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	24-51	coagulation factor II	Rattus norvegicus	93-101
22004609-7	2011	Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	24-51	nitric oxide synthase 2	Rattus norvegicus	110-114
22004609-7	2011	Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	53-57	coagulation factor II	Rattus norvegicus	93-101
22004609-7	2011	Treatment of cells with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) inhibited thrombin-induced iNOS expression in a concentration-dependent manner.	pyrrolidine dithiocarbamic acid	53-57	nitric oxide synthase 2	Rattus norvegicus	110-114
21912264-7	2011	Furthermore, with the addition of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B) and extracellular signal-regulated kinase inhibitors pyrrolidine dithiocarbamate and PD98059, the IL-17-induced CCL2 mRNA level was significantly compromised.	pyrrolidine dithiocarbamic acid	160-187	interleukin 17A	Homo sapiens	205-210
21912264-7	2011	Furthermore, with the addition of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B) and extracellular signal-regulated kinase inhibitors pyrrolidine dithiocarbamate and PD98059, the IL-17-induced CCL2 mRNA level was significantly compromised.	pyrrolidine dithiocarbamic acid	160-187	C-C motif chemokine ligand 2	Homo sapiens	219-223
21884795-11	2012	An NF-kappaB inhibitor, pyrrolidine dithiocarbamate prevented the MGO-induced NOX1 expression.	pyrrolidine dithiocarbamic acid	24-51	NADPH oxidase 1	Rattus norvegicus	78-82
23056624-5	2012	Pretreatment of the rabbits with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly attenuated neutrophil infiltration in the no-reflow area as well as the expansion of no-reflow.	pyrrolidine dithiocarbamic acid	65-92	nuclear factor kappa B subunit 1	Homo sapiens	44-53
23056624-5	2012	Pretreatment of the rabbits with a specific NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), significantly attenuated neutrophil infiltration in the no-reflow area as well as the expansion of no-reflow.	pyrrolidine dithiocarbamic acid	94-98	nuclear factor kappa B subunit 1	Homo sapiens	44-53
21917559-2	2011	Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling.	pyrrolidine dithiocarbamic acid	0-27	interleukin 6	Homo sapiens	78-82
21917559-2	2011	Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling.	pyrrolidine dithiocarbamic acid	0-27	signal transducer and activator of transcription 3	Homo sapiens	105-155
21917559-2	2011	Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling.	pyrrolidine dithiocarbamic acid	29-33	interleukin 6	Homo sapiens	78-82
21917559-2	2011	Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in signal transducer and activator of transcription-3 activation and downstream signaling.	pyrrolidine dithiocarbamic acid	29-33	signal transducer and activator of transcription 3	Homo sapiens	105-155
21687928-8	2011	Furthermore, the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore palmitate-induced caspase-3 decrease and inhibit palmitate-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	37-64	caspase 3	Mus musculus	104-113
21964477-7	2011	Blockade of NF-kappaB by ammonium pyrrolidinedithiocarbamate (PDTC) resulted in down-regulation of apoptosis.	pyrrolidine dithiocarbamic acid	25-60	nuclear factor kappa B subunit 1	Homo sapiens	12-21
21964477-7	2011	Blockade of NF-kappaB by ammonium pyrrolidinedithiocarbamate (PDTC) resulted in down-regulation of apoptosis.	pyrrolidine dithiocarbamic acid	62-66	nuclear factor kappa B subunit 1	Homo sapiens	12-21
21832251-6	2011	Inhibitors of NF-kappaB (pyrrolidine dithiocarbamate and isohelenin) and NF-kappaB p65 small interfering RNA (siRNA) suppressed indoxyl sulfate-induced senescence-associated beta-galactosidase activity and expression of p53, transforming growth factor (TGF)-beta1, and alpha-smoothe muscle actin (SMA).	pyrrolidine dithiocarbamic acid	25-52	nuclear factor kappa B subunit 1	Homo sapiens	14-23
21832251-6	2011	Inhibitors of NF-kappaB (pyrrolidine dithiocarbamate and isohelenin) and NF-kappaB p65 small interfering RNA (siRNA) suppressed indoxyl sulfate-induced senescence-associated beta-galactosidase activity and expression of p53, transforming growth factor (TGF)-beta1, and alpha-smoothe muscle actin (SMA).	pyrrolidine dithiocarbamic acid	25-52	galactosidase, beta 1	Rattus norvegicus	174-192
21999230-0	2011	Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats.	pyrrolidine dithiocarbamic acid	49-76	matrix metallopeptidase 9	Rattus norvegicus	19-45
21890516-12	2011	Lipopolysaccharide increased the mRNA expression of interleukin-6 and TNF-alpha in duodenal tissue, and this effect was partly reversed by PDTC, sulfasalazine and RO 106-9920.	pyrrolidine dithiocarbamic acid	139-143	interleukin-6	Oryctolagus cuniculus	52-65
21890516-12	2011	Lipopolysaccharide increased the mRNA expression of interleukin-6 and TNF-alpha in duodenal tissue, and this effect was partly reversed by PDTC, sulfasalazine and RO 106-9920.	pyrrolidine dithiocarbamic acid	139-143	tumor necrosis factor	Oryctolagus cuniculus	70-79
21687928-8	2011	Furthermore, the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore palmitate-induced caspase-3 decrease and inhibit palmitate-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	37-64	caspase 3	Mus musculus	161-170
21687928-8	2011	Furthermore, the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore palmitate-induced caspase-3 decrease and inhibit palmitate-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	66-70	caspase 3	Mus musculus	104-113
21687928-8	2011	Furthermore, the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) could restore palmitate-induced caspase-3 decrease and inhibit palmitate-induced cleaved caspase-3 increase.	pyrrolidine dithiocarbamic acid	66-70	caspase 3	Mus musculus	161-170
21620964-9	2011	Furthermore, other NF-kappaB inhibitors, such as pyrrolidine dithiocarbamate (PDTC) and MG132, also increased HO-1 mRNA and protein expression.	pyrrolidine dithiocarbamic acid	49-76	heme oxygenase 1	Homo sapiens	110-114
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	45-72	matrix metallopeptidase 2	Rattus norvegicus	121-125
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	45-72	matrix metallopeptidase 2	Rattus norvegicus	192-197
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	45-72	matrix metallopeptidase 9	Rattus norvegicus	202-207
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	74-78	matrix metallopeptidase 2	Rattus norvegicus	121-125
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	74-78	matrix metallopeptidase 2	Rattus norvegicus	192-197
21434884-2	2011	We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-kappaB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9 up-regulation, and protect against the functional alterations and vascular remodelling of two-kidney, one clip (2K1C) hypertension.	pyrrolidine dithiocarbamic acid	74-78	matrix metallopeptidase 9	Rattus norvegicus	202-207
21620964-9	2011	Furthermore, other NF-kappaB inhibitors, such as pyrrolidine dithiocarbamate (PDTC) and MG132, also increased HO-1 mRNA and protein expression.	pyrrolidine dithiocarbamic acid	78-82	heme oxygenase 1	Homo sapiens	110-114
21684102-6	2011	Furthermore, the TIMP-1-induced attenuation of the effect of epirubicin and paclitaxel was reversed by the PI3K/Akt chemical inhibitor LY294002 and the NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC), showing that the PI3K/Akt and NF-kB signaling pathway was involved in the TIMP-1-induced effect on chemoresistance.	pyrrolidine dithiocarbamic acid	168-195	TIMP metallopeptidase inhibitor 1	Homo sapiens	17-23
21229292-5	2011	SN50, curcumin, oridonin, and pyrrolidine dithiocarbamate (PDTC) all sensitized cells to TRAIL-induced apoptosis.	pyrrolidine dithiocarbamic acid	30-57	TNF superfamily member 10	Homo sapiens	89-94
21229292-5	2011	SN50, curcumin, oridonin, and pyrrolidine dithiocarbamate (PDTC) all sensitized cells to TRAIL-induced apoptosis.	pyrrolidine dithiocarbamic acid	59-63	TNF superfamily member 10	Homo sapiens	89-94
21229292-8	2011	Instead, the free radical scavenger N-acetyl-L: -cysteine (NAC) completely blocked the effect on TRAIL-induced apoptosis caused by curcumin, oridonin, and PDTC.	pyrrolidine dithiocarbamic acid	155-159	TNF superfamily member 10	Homo sapiens	97-102
21592969-5	2011	In this study, we cultured rat metatarsal bones in the presence of GH and/or pyrrolidine dithiocarbamate (PDTC), a known NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	77-104	nuclear factor kappa B subunit 1	Homo sapiens	121-130
21592969-5	2011	In this study, we cultured rat metatarsal bones in the presence of GH and/or pyrrolidine dithiocarbamate (PDTC), a known NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	106-110	nuclear factor kappa B subunit 1	Homo sapiens	121-130
21520052-6	2011	Pretreatment with c-Src inhibitor (PP2), Akt inhibitor and NF-kappaB inhibitor (pyrrolidine dithiocarbamate and L-1-tosylamido-2-phenylenylethyl chloromethyl ketone) also inhibited the potentiating action of HMGB-1.	pyrrolidine dithiocarbamic acid	80-107	nuclear factor kappa B subunit 1	Homo sapiens	59-68
21161674-5	2011	Pyrrolidine dithiocarbamate (PDTC) treatment inhibited NF-kappaB activation and Bcl-2 expression and committed resveratrol-treated cells to apoptosis at the 8-h time point without the step of neuron-oriented differentiation.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor kappa B subunit 1	Homo sapiens	55-64
21161674-5	2011	Pyrrolidine dithiocarbamate (PDTC) treatment inhibited NF-kappaB activation and Bcl-2 expression and committed resveratrol-treated cells to apoptosis at the 8-h time point without the step of neuron-oriented differentiation.	pyrrolidine dithiocarbamic acid	0-27	BCL2 apoptosis regulator	Homo sapiens	80-85
21161674-5	2011	Pyrrolidine dithiocarbamate (PDTC) treatment inhibited NF-kappaB activation and Bcl-2 expression and committed resveratrol-treated cells to apoptosis at the 8-h time point without the step of neuron-oriented differentiation.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor kappa B subunit 1	Homo sapiens	55-64
21161674-5	2011	Pyrrolidine dithiocarbamate (PDTC) treatment inhibited NF-kappaB activation and Bcl-2 expression and committed resveratrol-treated cells to apoptosis at the 8-h time point without the step of neuron-oriented differentiation.	pyrrolidine dithiocarbamic acid	29-33	BCL2 apoptosis regulator	Homo sapiens	80-85
21566130-3	2011	Proepithelin-mediated stimulation of metatarsal growth and growth plate chondrogenesis was neutralized by pyrrolidine dithiocarbamate, a known NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	106-133	granulin precursor	Rattus norvegicus	0-12
21566130-5	2011	The inhibition of NF-kappaB-p65 expression and activity (by p65 short interfering RNA (siRNA) and pyrrolidine dithiocarbamate, respectively) in chondrocytes reversed the proepithelin-mediated induction of cell proliferation and differentiation and the proepithelin-mediated prevention of cell apoptosis.	pyrrolidine dithiocarbamic acid	98-125	synaptotagmin 1	Rattus norvegicus	28-31
21566130-5	2011	The inhibition of NF-kappaB-p65 expression and activity (by p65 short interfering RNA (siRNA) and pyrrolidine dithiocarbamate, respectively) in chondrocytes reversed the proepithelin-mediated induction of cell proliferation and differentiation and the proepithelin-mediated prevention of cell apoptosis.	pyrrolidine dithiocarbamic acid	98-125	granulin precursor	Rattus norvegicus	170-182
21684102-6	2011	Furthermore, the TIMP-1-induced attenuation of the effect of epirubicin and paclitaxel was reversed by the PI3K/Akt chemical inhibitor LY294002 and the NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC), showing that the PI3K/Akt and NF-kB signaling pathway was involved in the TIMP-1-induced effect on chemoresistance.	pyrrolidine dithiocarbamic acid	197-201	TIMP metallopeptidase inhibitor 1	Homo sapiens	17-23
21306738-4	2011	Examination of the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) indicated that direct application of the drug slowly hyperpolarized mdx fibers (7 mV in 90 min) but had no effect on nondystrophic fibers.	pyrrolidine dithiocarbamic acid	54-81	nuclear factor kappa B subunit 1	Homo sapiens	34-43
21262221-5	2011	NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC) suppressed autophagy.	pyrrolidine dithiocarbamic acid	50-54	nuclear factor kappa B subunit 1	Homo sapiens	0-9
21306738-4	2011	Examination of the effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) indicated that direct application of the drug slowly hyperpolarized mdx fibers (7 mV in 90 min) but had no effect on nondystrophic fibers.	pyrrolidine dithiocarbamic acid	83-87	nuclear factor kappa B subunit 1	Homo sapiens	34-43
21483034-2	2011	Here we demonstrated that inhibition of NF-kappaB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.	pyrrolidine dithiocarbamic acid	55-82	Relish	Drosophila melanogaster	40-49
21327328-10	2011	Using the p38 inhibitor, SB203580, the ERK1/2 inhibitor PD98059, the NF-kappaB inhibitor, pyrrolidine dithiocarbamate and the NAMPT inhibitor FK866, we demonstrated that the visfatin pro-inflammatory action was through the NAMPT-MAPK (p38, ERK1/2)-NF-kappaB pathway.	pyrrolidine dithiocarbamic acid	90-117	nicotinamide phosphoribosyltransferase	Homo sapiens	174-182
21673371-10	2011	Experiments with HAECs pretreated with pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, revealed that both LA and EA-mediated induction of ICAM-1 and VCAM-1 is mainly regulated by NF-kappaB.	pyrrolidine dithiocarbamic acid	39-66	nuclear factor kappa B subunit 1	Homo sapiens	84-93
21673371-10	2011	Experiments with HAECs pretreated with pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, revealed that both LA and EA-mediated induction of ICAM-1 and VCAM-1 is mainly regulated by NF-kappaB.	pyrrolidine dithiocarbamic acid	39-66	intercellular adhesion molecule 1	Homo sapiens	146-152
21673371-10	2011	Experiments with HAECs pretreated with pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, revealed that both LA and EA-mediated induction of ICAM-1 and VCAM-1 is mainly regulated by NF-kappaB.	pyrrolidine dithiocarbamic acid	39-66	vascular cell adhesion molecule 1	Homo sapiens	157-163
21673371-10	2011	Experiments with HAECs pretreated with pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, revealed that both LA and EA-mediated induction of ICAM-1 and VCAM-1 is mainly regulated by NF-kappaB.	pyrrolidine dithiocarbamic acid	39-66	nuclear factor kappa B subunit 1	Homo sapiens	187-196
21354106-9	2011	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly increased the transcription of pro-apoptosis proteins (p53 and Fas) by NF-kappaB, and attenuated the anti-apoptotic effects of CREG on MSCs.	pyrrolidine dithiocarbamic acid	48-75	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	152-155
21354106-9	2011	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) significantly increased the transcription of pro-apoptosis proteins (p53 and Fas) by NF-kappaB, and attenuated the anti-apoptotic effects of CREG on MSCs.	pyrrolidine dithiocarbamic acid	77-81	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	152-155
20573495-10	2011	The inhibition of oxysterol-induced cytokine stimulation was also mimicked by the specific NF-kappaB inhibitor pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	111-138	nuclear factor kappa B subunit 1	Homo sapiens	91-100
21130118-6	2011	Furthermore, pre-infusion of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, into the NAc blocked the CPP but also the phosphorylation of NF-kappaB p65 induced by morphine.	pyrrolidine dithiocarbamic acid	29-56	synaptotagmin 1	Rattus norvegicus	169-172
21130118-6	2011	Furthermore, pre-infusion of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, into the NAc blocked the CPP but also the phosphorylation of NF-kappaB p65 induced by morphine.	pyrrolidine dithiocarbamic acid	58-62	synaptotagmin 1	Rattus norvegicus	169-172
21949808-5	2011	The effect of NF-kappaB inhibitor, ammonium pyrrolidinedithiocarbamate (PDTC), on ALI was detected.	pyrrolidine dithiocarbamic acid	72-76	nuclear factor kappa B subunit 1	Homo sapiens	14-23
21047552-4	2011	The protective inhibitory actions of pyrrolidine dithiocarbamate (PDTC), a pharmacological inhibitor of NF-kappaB and a potent antioxidant, make this a good agent to evaluate the role of inhibition of NF-kappaB and prevention of excessive ECM deposition in maladaptive cardiac remodeling during HF.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
21047552-4	2011	The protective inhibitory actions of pyrrolidine dithiocarbamate (PDTC), a pharmacological inhibitor of NF-kappaB and a potent antioxidant, make this a good agent to evaluate the role of inhibition of NF-kappaB and prevention of excessive ECM deposition in maladaptive cardiac remodeling during HF.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	201-210
21047552-4	2011	The protective inhibitory actions of pyrrolidine dithiocarbamate (PDTC), a pharmacological inhibitor of NF-kappaB and a potent antioxidant, make this a good agent to evaluate the role of inhibition of NF-kappaB and prevention of excessive ECM deposition in maladaptive cardiac remodeling during HF.	pyrrolidine dithiocarbamic acid	66-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
21220710-8	2011	Furthermore, MMP-2 and MMP-9 activities in SHR plasma were significantly reduced (  41%) by pyrrolidine dithiocarbamate treatment.	pyrrolidine dithiocarbamic acid	92-119	matrix metallopeptidase 2	Rattus norvegicus	13-18
21220710-8	2011	Furthermore, MMP-2 and MMP-9 activities in SHR plasma were significantly reduced (  41%) by pyrrolidine dithiocarbamate treatment.	pyrrolidine dithiocarbamic acid	92-119	matrix metallopeptidase 9	Rattus norvegicus	23-28
21220710-10	2011	The level of the beta2AR extracellular, but not intracellular, domain density was found to be reduced in kidney, showing a receptor cleavage process that can be blocked by pyrrolidine dithiocarbamate treatment.	pyrrolidine dithiocarbamic acid	172-199	adrenoceptor beta 2	Rattus norvegicus	17-24
21968252-0	2011	Pyrrolidine dithiocarbamate attenuates nuclear factor-kB activation, cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic epithelial cells.	pyrrolidine dithiocarbamic acid	0-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-85
20809699-8	2011	The levels of G-CSF mRNA in PGM-treated PBMC could be reduced by ERK inhibitor U0126 and NF-kappaB inhibitor pyrrolidine dithiocarbamate, respectively.	pyrrolidine dithiocarbamic acid	109-136	phosphoglycerate mutase-like protein	Glycine max	28-31
22289529-5	2011	Additionally, the NF-kappaB inhibitor pyrrolidine dithiocarbamate caused a reduction in COX-2 protein levels and NF-kappaB activation, similar to the effect of genistein.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	18-27
22289529-5	2011	Additionally, the NF-kappaB inhibitor pyrrolidine dithiocarbamate caused a reduction in COX-2 protein levels and NF-kappaB activation, similar to the effect of genistein.	pyrrolidine dithiocarbamic acid	38-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
22289529-5	2011	Additionally, the NF-kappaB inhibitor pyrrolidine dithiocarbamate caused a reduction in COX-2 protein levels and NF-kappaB activation, similar to the effect of genistein.	pyrrolidine dithiocarbamic acid	38-65	nuclear factor kappa B subunit 1	Homo sapiens	113-122
21720097-9	2011	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of the activation of NF-kappaB, per se produced a significant antianxiety-like activity in stressed mice.	pyrrolidine dithiocarbamic acid	0-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
21720097-9	2011	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of the activation of NF-kappaB, per se produced a significant antianxiety-like activity in stressed mice.	pyrrolidine dithiocarbamic acid	29-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
20920558-6	2010	PDTC/Cu complex dramatically enhanced the JNK protein phosphorylation and ERK protein phosphorylation proteins.	pyrrolidine dithiocarbamic acid	0-4	mitogen-activated protein kinase 8	Homo sapiens	42-45
20920558-6	2010	PDTC/Cu complex dramatically enhanced the JNK protein phosphorylation and ERK protein phosphorylation proteins.	pyrrolidine dithiocarbamic acid	0-4	mitogen-activated protein kinase 1	Homo sapiens	74-77
20920558-8	2010	PDTC/Cu complex was capable of activating the apoptosis-related caspases including caspase-9, caspase-7, and caspase-3, which could be reversed by the addition of JNK inhibitor SP600125 or transfection of MAPK8 short hairpin RNA.	pyrrolidine dithiocarbamic acid	0-4	caspase 9	Homo sapiens	83-92
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	pyrrolidine dithiocarbamic acid	35-62	nuclear factor kappa B subunit 1	Homo sapiens	4-13
20920558-8	2010	PDTC/Cu complex was capable of activating the apoptosis-related caspases including caspase-9, caspase-7, and caspase-3, which could be reversed by the addition of JNK inhibitor SP600125 or transfection of MAPK8 short hairpin RNA.	pyrrolidine dithiocarbamic acid	0-4	caspase 7	Homo sapiens	94-103
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	pyrrolidine dithiocarbamic acid	35-62	interleukin 1 receptor associated kinase 2	Homo sapiens	90-96
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	pyrrolidine dithiocarbamic acid	35-62	microRNA 146a	Homo sapiens	101-111
20920558-8	2010	PDTC/Cu complex was capable of activating the apoptosis-related caspases including caspase-9, caspase-7, and caspase-3, which could be reversed by the addition of JNK inhibitor SP600125 or transfection of MAPK8 short hairpin RNA.	pyrrolidine dithiocarbamic acid	0-4	caspase 3	Homo sapiens	109-118
20920558-8	2010	PDTC/Cu complex was capable of activating the apoptosis-related caspases including caspase-9, caspase-7, and caspase-3, which could be reversed by the addition of JNK inhibitor SP600125 or transfection of MAPK8 short hairpin RNA.	pyrrolidine dithiocarbamic acid	0-4	mitogen-activated protein kinase 8	Homo sapiens	163-166
20920558-8	2010	PDTC/Cu complex was capable of activating the apoptosis-related caspases including caspase-9, caspase-7, and caspase-3, which could be reversed by the addition of JNK inhibitor SP600125 or transfection of MAPK8 short hairpin RNA.	pyrrolidine dithiocarbamic acid	0-4	mitogen-activated protein kinase 8	Homo sapiens	205-210
20876703-2	2010	Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding the c-Jun-N-terminal protein kinase (JNK) inhibitor, SP600125, the nuclear factor-kappa B (NF-kappaB) inhibitor, BAY117082 and pyrrolidine dithiocarbamic acid and a dominant-negative JNK.	pyrrolidine dithiocarbamic acid	231-262	nitric oxide synthase 2	Homo sapiens	10-14
20876703-2	2010	Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding the c-Jun-N-terminal protein kinase (JNK) inhibitor, SP600125, the nuclear factor-kappa B (NF-kappaB) inhibitor, BAY117082 and pyrrolidine dithiocarbamic acid and a dominant-negative JNK.	pyrrolidine dithiocarbamic acid	231-262	mitogen-activated protein kinase 8	Homo sapiens	108-139
20876703-2	2010	Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding the c-Jun-N-terminal protein kinase (JNK) inhibitor, SP600125, the nuclear factor-kappa B (NF-kappaB) inhibitor, BAY117082 and pyrrolidine dithiocarbamic acid and a dominant-negative JNK.	pyrrolidine dithiocarbamic acid	231-262	mitogen-activated protein kinase 8	Homo sapiens	141-144
20876703-2	2010	Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding the c-Jun-N-terminal protein kinase (JNK) inhibitor, SP600125, the nuclear factor-kappa B (NF-kappaB) inhibitor, BAY117082 and pyrrolidine dithiocarbamic acid and a dominant-negative JNK.	pyrrolidine dithiocarbamic acid	231-262	nuclear factor kappa B subunit 1	Homo sapiens	171-193
20876703-2	2010	Increased iNOS/NO induction and migration of macrophages by MDA-CM were significantly blocked by adding the c-Jun-N-terminal protein kinase (JNK) inhibitor, SP600125, the nuclear factor-kappa B (NF-kappaB) inhibitor, BAY117082 and pyrrolidine dithiocarbamic acid and a dominant-negative JNK.	pyrrolidine dithiocarbamic acid	231-262	nuclear factor kappa B subunit 1	Homo sapiens	195-204
21208093-0	2010	Pyrrolidine dithiocarbamate modulates HSP70, iNOS, and apoptosis during hemorrhagic shock resuscitation in rats.	pyrrolidine dithiocarbamic acid	0-27	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	38-43
21208093-0	2010	Pyrrolidine dithiocarbamate modulates HSP70, iNOS, and apoptosis during hemorrhagic shock resuscitation in rats.	pyrrolidine dithiocarbamic acid	0-27	nitric oxide synthase 2	Rattus norvegicus	45-49
21179282-8	2010	Treatment with inhibitors of nuclear factor-kappaB (NF-kappaB), i.e., pyrrolidine dithiocarbamate and parthenolide, abrogated the stimulatory effect of poly (I:C) on the production of VEGF and IL-8 in RA FLS.	pyrrolidine dithiocarbamic acid	70-97	vascular endothelial growth factor A	Homo sapiens	184-188
21179282-8	2010	Treatment with inhibitors of nuclear factor-kappaB (NF-kappaB), i.e., pyrrolidine dithiocarbamate and parthenolide, abrogated the stimulatory effect of poly (I:C) on the production of VEGF and IL-8 in RA FLS.	pyrrolidine dithiocarbamic acid	70-97	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
20817067-7	2010	The LPS-induced TG2 expression was diminished by ammonium pyrrolidine-1-carbodithioate; an inhibitor for nuclear factor (NF)-kappaB activation, suggesting the factors involved.	pyrrolidine dithiocarbamic acid	49-86	transglutaminase 2	Rattus norvegicus	16-19
21131739-1	2010	OBJECTIVE: To observe the effect of intrathecal injection of nuclear factor-kappaB (NF-kappaB) inhibitor of pyrrolidine dithiocarbamate (PDTC) on pain sensitivity thresholds and the expression of spinal cord CX3C chemokine receptor 1 (CX3CR1) in monoarthritis (MA) model in rats.	pyrrolidine dithiocarbamic acid	137-141	C-X3-C motif chemokine receptor 1	Rattus norvegicus	208-233
21131739-1	2010	OBJECTIVE: To observe the effect of intrathecal injection of nuclear factor-kappaB (NF-kappaB) inhibitor of pyrrolidine dithiocarbamate (PDTC) on pain sensitivity thresholds and the expression of spinal cord CX3C chemokine receptor 1 (CX3CR1) in monoarthritis (MA) model in rats.	pyrrolidine dithiocarbamic acid	137-141	C-X3-C motif chemokine receptor 1	Rattus norvegicus	235-241
20692357-0	2010	Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3.	pyrrolidine dithiocarbamic acid	50-77	heat shock transcription factor 1	Homo sapiens	14-33
20692357-0	2010	Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3.	pyrrolidine dithiocarbamic acid	50-77	BAG cochaperone 3	Homo sapiens	118-122
21089680-1	2010	This investigation was made with special reference to the effect of the combined use of nuclear factor-kappaB (NF-kappaB) inhibitor Pyrrolidine dithiocarbamate(PDTC) and Paclitaxel on the expression of Matrix metalloproteinases (MMP-9) and its inhibitor TIMP-1, and on the proliferation and invasion of human breast cancer cell line MCF-7.	pyrrolidine dithiocarbamic acid	132-159	matrix metallopeptidase 9	Homo sapiens	229-234
20887552-7	2010	Specific NF-kappaB inhibitors (pyrrolidine dithiocarbamate, PDTC), or dominant-negative inhibitor (I kappa B alpha mutant, IkappaBalphaM) abrogated the Id1-induced cell proliferation and keratin 10 production whereas p65, a subunit of the NF-kappaB heterodimer and an enhancer of the NF-kappaB activity, strengthened the Id1-induced cell proliferation and keratin 10 production.	pyrrolidine dithiocarbamic acid	31-58	nuclear factor kappa B subunit 1	Homo sapiens	9-18
20887552-7	2010	Specific NF-kappaB inhibitors (pyrrolidine dithiocarbamate, PDTC), or dominant-negative inhibitor (I kappa B alpha mutant, IkappaBalphaM) abrogated the Id1-induced cell proliferation and keratin 10 production whereas p65, a subunit of the NF-kappaB heterodimer and an enhancer of the NF-kappaB activity, strengthened the Id1-induced cell proliferation and keratin 10 production.	pyrrolidine dithiocarbamic acid	31-58	inhibitor of DNA binding 1, HLH protein	Homo sapiens	152-155
21089680-1	2010	This investigation was made with special reference to the effect of the combined use of nuclear factor-kappaB (NF-kappaB) inhibitor Pyrrolidine dithiocarbamate(PDTC) and Paclitaxel on the expression of Matrix metalloproteinases (MMP-9) and its inhibitor TIMP-1, and on the proliferation and invasion of human breast cancer cell line MCF-7.	pyrrolidine dithiocarbamic acid	132-159	TIMP metallopeptidase inhibitor 1	Homo sapiens	254-260
20522648-3	2010	In a tissue culture system, the LPS-induced decrease in the AQP5 mRNA level was blocked completely by pyrrolidine dithiocarbamate, MG132, tyrphostin AG126, SP600125, and partially by SB203580, which are inhibitors for IkappaB kinase, 26S proteasome, ERK1/2, JNK, and p38 MAPK, respectively.	pyrrolidine dithiocarbamic acid	102-129	aquaporin 5	Mus musculus	60-64
19997973-10	2010	Compared to the severe acute pancreatitis group, the pancreas nuclear factor-kappaB activity, tumor necrosis factor-alpha, high-mobility group box protein-1 levels in the pyrrolidine dithiocarbamate-treated group all remarkably decreased (p&lt;0.05).	pyrrolidine dithiocarbamic acid	171-198	tumor necrosis factor	Rattus norvegicus	94-121
19997973-12	2010	Pyrrolidine dithiocarbamate might inhibit the activation of nuclear factor-kappaB to blockade tumor necrosis factor-alpha, thereby indirectly suppressing the high-mobility group box protein-1 and reducing pancreatic tissue damage in rats with severe acute pancreatitis.	pyrrolidine dithiocarbamic acid	0-27	tumor necrosis factor	Rattus norvegicus	94-121
20349326-4	2010	A significant and dose-dependent inhibition of IL-4-induced MCP-1 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate and epigallocatechin gallate, indicating that IL-4-induced MCP-1 expression is mediated via a ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	137-164	interleukin 4	Mus musculus	47-51
20349326-4	2010	A significant and dose-dependent inhibition of IL-4-induced MCP-1 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate and epigallocatechin gallate, indicating that IL-4-induced MCP-1 expression is mediated via a ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	137-164	chemokine (C-C motif) ligand 2	Mus musculus	60-65
20349326-4	2010	A significant and dose-dependent inhibition of IL-4-induced MCP-1 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate and epigallocatechin gallate, indicating that IL-4-induced MCP-1 expression is mediated via a ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	137-164	interleukin 4	Mus musculus	211-215
20349326-4	2010	A significant and dose-dependent inhibition of IL-4-induced MCP-1 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate and epigallocatechin gallate, indicating that IL-4-induced MCP-1 expression is mediated via a ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	137-164	chemokine (C-C motif) ligand 2	Mus musculus	224-229
20381502-7	2010	Further, AGE increased mRNA levels of monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1) and plasminogen activator inhibitor-1 (PAI-1) in mesangial cells, all of which were prevented by the treatments with PEDF, RAGE antibody or pyrrolidine dithiocarbamate, a NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	265-292	chemokine (C-C motif) ligand 2	Mus musculus	38-72
20381502-7	2010	Further, AGE increased mRNA levels of monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1) and plasminogen activator inhibitor-1 (PAI-1) in mesangial cells, all of which were prevented by the treatments with PEDF, RAGE antibody or pyrrolidine dithiocarbamate, a NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	265-292	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	164-169
20514517-0	2010	Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?	pyrrolidine dithiocarbamic acid	0-27	mitogen-activated protein kinase 14	Mus musculus	38-41
20651843-4	2010	The cytotoxicity of adenosine alone or in combination with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was also evaluated by MTT assay and the mode of cell death was detected by Hoechst 33342 staining.	pyrrolidine dithiocarbamic acid	83-110	nuclear factor kappa B subunit 1	Homo sapiens	62-71
20118485-12	2010	However, all above parameters were diminished after pyrrolidine dithiocarbamate (PDTC)-incubation, a NF-kappaB inhibitor (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	52-79	nuclear factor kappa B subunit 1	Homo sapiens	101-110
20538789-4	2010	LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS-enhanced MCP-1 production.	pyrrolidine dithiocarbamic acid	150-177	chemokine (C-C motif) ligand 2	Mus musculus	27-32
20538789-4	2010	LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS-enhanced MCP-1 production.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-91
20538789-4	2010	LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS-enhanced MCP-1 production.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-101
20538789-4	2010	LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS-enhanced MCP-1 production.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-139
20538789-4	2010	LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS-enhanced MCP-1 production.	pyrrolidine dithiocarbamic acid	150-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-139
20723297-3	2010	After inhibiting the activation of NF-kappaB with noncytotoxic concentration of antioxidant pyrrolidine dithiocarbamate (PDTC) in vitro, the multiple of drug resistance of K562/AO2 cells was assessed by MTT assay.	pyrrolidine dithiocarbamic acid	92-119	nuclear factor kappa B subunit 1	Homo sapiens	35-44
20723297-3	2010	After inhibiting the activation of NF-kappaB with noncytotoxic concentration of antioxidant pyrrolidine dithiocarbamate (PDTC) in vitro, the multiple of drug resistance of K562/AO2 cells was assessed by MTT assay.	pyrrolidine dithiocarbamic acid	121-125	nuclear factor kappa B subunit 1	Homo sapiens	35-44
20155797-5	2010	In addition, application bilaterally into the hippocampal CA3 subfield of a selective NF-kappaB inhibitor, pyrrolidine dithiocarbamate or double-stranded kappaB decoy DNA significantly antagonized the activated NOS II-peroxynitrite signaling cascade (3 hr) and the associated manifestations of apoptotic cell death (7 days) in the hippocampus.	pyrrolidine dithiocarbamic acid	107-134	carbonic anhydrase 3	Rattus norvegicus	58-61
20118485-12	2010	However, all above parameters were diminished after pyrrolidine dithiocarbamate (PDTC)-incubation, a NF-kappaB inhibitor (P &lt; 0.05).	pyrrolidine dithiocarbamic acid	81-85	nuclear factor kappa B subunit 1	Homo sapiens	101-110
20037166-3	2010	The aim of this investigation was to evaluate the anti-cancer effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, in a murine xenograft model of RCC.	pyrrolidine dithiocarbamic acid	72-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
20812531-0	2010	Pyrrolidine dithiocarbamate treatment prevents ethylene glycol-induced urolithiasis through inhibition of NF-kappaB and p38-MAPK signaling pathways in rat kidney.	pyrrolidine dithiocarbamic acid	0-27	mitogen activated protein kinase 14	Rattus norvegicus	120-123
19903119-5	2010	INTERVENTION(S): Specific NFkappaB inhibitor 1-Pyrrolidinecarbodithioic acid ammonium salt (PDTC) was used in cell cultures.	pyrrolidine dithiocarbamic acid	45-90	nuclear factor kappa B subunit 1	Homo sapiens	26-34
20337886-10	2010	A cAMP-dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E(2) production and NF kappaB translocation.	pyrrolidine dithiocarbamic acid	99-126	nuclear factor kappa B subunit 1	Homo sapiens	54-75
20337886-10	2010	A cAMP-dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E(2) production and NF kappaB translocation.	pyrrolidine dithiocarbamic acid	99-126	nuclear factor kappa B subunit 1	Homo sapiens	77-86
20337886-10	2010	A cAMP-dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E(2) production and NF kappaB translocation.	pyrrolidine dithiocarbamic acid	99-126	TNF superfamily member 11	Homo sapiens	138-143
20337886-10	2010	A cAMP-dependent protein kinase inhibitor, H89, and a nuclear factor kappaB (NF kappaB) inhibitor, pyrrolidine dithiocarbamate, inhibited RANKL expression, prostaglandin E(2) production and NF kappaB translocation.	pyrrolidine dithiocarbamic acid	99-126	nuclear factor kappa B subunit 1	Homo sapiens	190-199
20201990-6	2010	We further show that the production of NO and pro-inflammatory cytokines in response to rRv2626c is mediated by the transcription factor nuclear factor (NF)-kappaB, and this was further confirmed using pyrrolidine dithiocarbamate (PDTC), a specific pharmacological inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	202-229	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-163
20037166-3	2010	The aim of this investigation was to evaluate the anti-cancer effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, in a murine xenograft model of RCC.	pyrrolidine dithiocarbamic acid	101-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
20424663-6	2010	Moreover, these effects were partially inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	52-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
20921832-2	2010	Here, we examined the effects of intrathecal pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, on the development of neuropathic pain, spinal microglial activation, and CX3CR1 expression induced by sciatic chronic constriction injury (CCI) model in rats.	pyrrolidine dithiocarbamic acid	45-72	C-X3-C motif chemokine receptor 1	Rattus norvegicus	178-184
20424663-6	2010	Moreover, these effects were partially inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor.	pyrrolidine dithiocarbamic acid	81-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
20079464-4	2010	Pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) and alpha-Bungarotoxin (alpha-Btx, nicotinic acetylcholine receptor antagonist) attenuated the nicotine-induced COX-2 expression and PGE(2) production.	pyrrolidine dithiocarbamic acid	0-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173
19856104-0	2010	Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma.	pyrrolidine dithiocarbamic acid	91-118	nuclear factor kappa B subunit 1	Homo sapiens	14-36
19856104-4	2010	In this study, we examined the synergistic effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, and cisplatin, on two human metastatic RCC cell lines ACHN and SN12K1.	pyrrolidine dithiocarbamic acid	82-86	nuclear factor kappa B subunit 1	Homo sapiens	91-100
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	26-34
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	62-89	interleukin 1 beta	Homo sapiens	117-125
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	134-142
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	62-89	nuclear factor kappa B subunit 1	Homo sapiens	134-142
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	91-95	interleukin 1 beta	Homo sapiens	117-125
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	91-95	nuclear factor kappa B subunit 1	Homo sapiens	134-142
19921217-4	2010	METHODS: The influence of NFkappaB inhibitors (dexamethasone, pyrrolidine dithiocarbamate (PDTC) and BAY 11-7082) on IL-1beta-induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB-secreted alkaline phosphatase reporter plasmid.	pyrrolidine dithiocarbamic acid	91-95	nuclear factor kappa B subunit 1	Homo sapiens	134-142
19889935-6	2010	The HCV-mediated activation of Nrf2 was abrogated in the presence of an antioxidant, PDTC (pyrrolidine dithiocarbamate), and a Ca(2+) chelator, BAPTA-AM [1,2-bis(aminophenoxy)ethane N,N,N,N-tetraacetic acid tetra(acetoxymethyl) ester], which suggests a role for both reactive oxygen species and Ca(2+) signalling in the Nrf2-activation process.	pyrrolidine dithiocarbamic acid	85-89	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
19889935-6	2010	The HCV-mediated activation of Nrf2 was abrogated in the presence of an antioxidant, PDTC (pyrrolidine dithiocarbamate), and a Ca(2+) chelator, BAPTA-AM [1,2-bis(aminophenoxy)ethane N,N,N,N-tetraacetic acid tetra(acetoxymethyl) ester], which suggests a role for both reactive oxygen species and Ca(2+) signalling in the Nrf2-activation process.	pyrrolidine dithiocarbamic acid	85-89	NFE2 like bZIP transcription factor 2	Homo sapiens	320-324
19889935-6	2010	The HCV-mediated activation of Nrf2 was abrogated in the presence of an antioxidant, PDTC (pyrrolidine dithiocarbamate), and a Ca(2+) chelator, BAPTA-AM [1,2-bis(aminophenoxy)ethane N,N,N,N-tetraacetic acid tetra(acetoxymethyl) ester], which suggests a role for both reactive oxygen species and Ca(2+) signalling in the Nrf2-activation process.	pyrrolidine dithiocarbamic acid	91-118	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
19889935-6	2010	The HCV-mediated activation of Nrf2 was abrogated in the presence of an antioxidant, PDTC (pyrrolidine dithiocarbamate), and a Ca(2+) chelator, BAPTA-AM [1,2-bis(aminophenoxy)ethane N,N,N,N-tetraacetic acid tetra(acetoxymethyl) ester], which suggests a role for both reactive oxygen species and Ca(2+) signalling in the Nrf2-activation process.	pyrrolidine dithiocarbamic acid	91-118	NFE2 like bZIP transcription factor 2	Homo sapiens	320-324
19666678-6	2010	Experiments using the NFkappaB inhibitor pyrrolidinedithiocarbamate also support that protection lent by OA-NO(2) was in part mediated by inhibition of NFkappaB.	pyrrolidine dithiocarbamic acid	41-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-30
19944683-4	2010	Incubation of ECs with the pyrrolidine-dithiocarbamate NFkappaB inhibitor prior to coculture, fully prevented coculture-induced expression of endothelial CAMs.	pyrrolidine dithiocarbamic acid	27-54	nuclear factor kappa B subunit 1	Homo sapiens	55-63
19729361-2	2010	Here, we investigated the effects of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, in diabetic mice.	pyrrolidine dithiocarbamic acid	37-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
19241163-8	2010	The antioxidant and NF-kappabeta inhibitor pyrrolidine dithiocarbamate (PDTC) was used as positive control.	pyrrolidine dithiocarbamic acid	43-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	20-32
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	182-209	interleukin 1 alpha	Rattus norvegicus	20-29
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	182-209	interleukin 1 beta	Rattus norvegicus	31-39
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	182-209	interleukin 6	Rattus norvegicus	44-48
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	182-209	mitogen activated protein kinase 3	Rattus norvegicus	121-127
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	182-209	mitogen activated protein kinase 14	Rattus norvegicus	139-142
20026063-4	2010	All specific NFkappaB and MAPKs pathway inhibitors (pyrrolidine dithiocarbamate, AG490, U0126, SB203580 and SP600125) remarkably attenuated NO production induced by the beta-glucan.	pyrrolidine dithiocarbamic acid	52-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-21
20389059-7	2010	Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC.	pyrrolidine dithiocarbamic acid	25-60	nuclear factor kappa B subunit 1	Homo sapiens	14-23
20389059-7	2010	Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC.	pyrrolidine dithiocarbamic acid	25-60	intercellular adhesion molecule 1	Homo sapiens	171-177
20389059-7	2010	Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC.	pyrrolidine dithiocarbamic acid	25-60	C-C motif chemokine ligand 2	Homo sapiens	182-187
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	211-215	interleukin 1 alpha	Rattus norvegicus	20-29
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	211-215	interleukin 1 beta	Rattus norvegicus	31-39
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	211-215	interleukin 6	Rattus norvegicus	44-48
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	211-215	mitogen activated protein kinase 3	Rattus norvegicus	121-127
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	pyrrolidine dithiocarbamic acid	211-215	mitogen activated protein kinase 14	Rattus norvegicus	139-142
19666678-6	2010	Experiments using the NFkappaB inhibitor pyrrolidinedithiocarbamate also support that protection lent by OA-NO(2) was in part mediated by inhibition of NFkappaB.	pyrrolidine dithiocarbamic acid	41-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	152-160
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	136-163	interleukin 4	Mus musculus	47-51
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	136-163	interleukin 6	Mus musculus	60-64
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	136-163	interleukin 4	Mus musculus	224-228
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	136-163	interleukin 6	Mus musculus	237-241
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	165-169	interleukin 4	Mus musculus	47-51
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	165-169	interleukin 6	Mus musculus	60-64
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	165-169	interleukin 4	Mus musculus	224-228
19822443-4	2010	A significant and dose-dependent inhibition of IL-4-induced IL-6 expression was observed in HAEC pre-treated with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and epigallocatechin gallate (EGCG), indicating that IL-4-induced IL-6 expression is mediated via an ROS-dependent mechanism.	pyrrolidine dithiocarbamic acid	165-169	interleukin 6	Mus musculus	237-241
20562516-6	2010	An Akt inhibitor, LY294002, and an NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited TNF-induced VCAM-1.	pyrrolidine dithiocarbamic acid	56-83	tumor necrosis factor	Rattus norvegicus	95-98
20562516-6	2010	An Akt inhibitor, LY294002, and an NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited TNF-induced VCAM-1.	pyrrolidine dithiocarbamic acid	56-83	vascular cell adhesion molecule 1	Rattus norvegicus	107-113
21127388-11	2010	The ET-induced expression of MMP9, but not MMP2, was inhibited by pyrrolidine dithiocarbamate, proteasome inhibitor I, and MG132.	pyrrolidine dithiocarbamic acid	66-93	matrix metallopeptidase 9	Rattus norvegicus	29-33
19956890-6	2010	A reduction in Hpa protein levels was observed when nuclear factor kappaB (NF-kappaB) activation was blocked by pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	112-139	heparanase	Homo sapiens	15-18
19816747-11	2009	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate decreased the AngII-mediated increase in MCP-1 mRNA.	pyrrolidine dithiocarbamic acid	27-54	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	69-74
19816747-11	2009	Inhibition of NF-kappaB by pyrrolidine dithiocarbamate decreased the AngII-mediated increase in MCP-1 mRNA.	pyrrolidine dithiocarbamic acid	27-54	chemokine (C-C motif) ligand 2	Mus musculus	96-101
19748488-5	2009	In addition, ET-1 was able to elicit reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) activation, and antioxidant pyrrolidine dithiocarbamate and p38MAPK inhibitor SB203580 inhibited ET-1-induced CRP expression.	pyrrolidine dithiocarbamic acid	150-177	endothelin 1	Rattus norvegicus	219-223
19748488-5	2009	In addition, ET-1 was able to elicit reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) activation, and antioxidant pyrrolidine dithiocarbamate and p38MAPK inhibitor SB203580 inhibited ET-1-induced CRP expression.	pyrrolidine dithiocarbamic acid	150-177	C-reactive protein	Rattus norvegicus	232-235
19727662-9	2009	By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB.	pyrrolidine dithiocarbamic acid	70-97	nitric oxide synthase 2	Homo sapiens	119-123
19727662-9	2009	By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB.	pyrrolidine dithiocarbamic acid	70-97	nicotinamide phosphoribosyltransferase	Homo sapiens	143-148
19727662-9	2009	By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB.	pyrrolidine dithiocarbamic acid	70-97	nicotinamide phosphoribosyltransferase	Homo sapiens	149-157
19727662-9	2009	By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB.	pyrrolidine dithiocarbamic acid	70-97	mitogen-activated protein kinase 3	Homo sapiens	206-213