PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33986510-7	2021	Intraperitoneally administered periplogenin exhibited efficacious therapeutic effects in ESCC patient-derived xenograft models and dramatically impaired the phosphorylation of STAT3 and expression levels of STAT3-mediated downstream genes.	periplogenin	31-43	signal transducer and activator of transcription 3	Homo sapiens	176-181
33986510-7	2021	Intraperitoneally administered periplogenin exhibited efficacious therapeutic effects in ESCC patient-derived xenograft models and dramatically impaired the phosphorylation of STAT3 and expression levels of STAT3-mediated downstream genes.	periplogenin	31-43	signal transducer and activator of transcription 3	Homo sapiens	207-212
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	heat shock protein family A (Hsp70) member 5	Homo sapiens	39-42
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	eukaryotic translation initiation factor 2A	Homo sapiens	46-55
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	DNA damage inducible transcript 3	Homo sapiens	60-64
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	76-85
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	mitogen-activated protein kinase 8	Homo sapiens	92-95
32640963-9	2021	PPG up-regulated the protein levels of BIP, p-eIF2alpha and CHOP as well as IRE1alpha and p-JNK, and down-regulated the protein level of p-ASK1, all of which were reversed by N-acetylsysteine.	periplogenin	0-3	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	periplogenin	49-61	X-linked Kx blood group	Homo sapiens	77-80
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	periplogenin	49-61	proprotein convertase subtilisin/kexin type 1	Homo sapiens	102-107
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	periplogenin	49-61	X-linked Kx blood group	Homo sapiens	142-145
32640963-10	2021	Importantly, knockdown of CHOP or JNK protein level attenuated the PPG-elicited apoptosis.	periplogenin	67-70	DNA damage inducible transcript 3	Homo sapiens	26-30
32640963-10	2021	Importantly, knockdown of CHOP or JNK protein level attenuated the PPG-elicited apoptosis.	periplogenin	67-70	mitogen-activated protein kinase 8	Homo sapiens	34-37
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	heat shock protein family A (Hsp70) member 5	Homo sapiens	65-68
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	eukaryotic translation initiation factor 2A	Homo sapiens	69-78
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	DNA damage inducible transcript 3	Homo sapiens	79-83
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	heat shock protein family A (Hsp70) member 5	Homo sapiens	88-91
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	92-96
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	12-15	mitogen-activated protein kinase 8	Homo sapiens	97-100
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	157-160	heat shock protein family A (Hsp70) member 5	Homo sapiens	65-68
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	157-160	eukaryotic translation initiation factor 2A	Homo sapiens	69-78
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	157-160	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	92-96
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	periplogenin	157-160	mitogen-activated protein kinase 8	Homo sapiens	97-100