PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33596421-0	2021	An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.	acetyl-histone	3-17	AKT serine/threonine kinase 1	Homo sapiens	40-43
33596421-0	2021	An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.	acetyl-histone	3-17	delta/notch like EGF repeat containing	Homo sapiens	95-98
33596421-0	2021	An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.	acetyl-histone	3-17	histone deacetylase 9	Homo sapiens	103-107
33596421-6	2021	Targeting this unique acetyl-histone-related vulnerability offers two clinically viable strategies to overcome PI3K/AKT inhibitor resistance in different cancers.	acetyl-histone	22-36	AKT serine/threonine kinase 1	Homo sapiens	116-119
31409188-1	2019	RATIONALE: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in preclinical models of heart failure (HF).	acetyl-histone	44-58	bromodomain containing 4	Rattus norvegicus	75-79
33185915-4	2021	The acetyl-histone H4 and trimethylated histone H3-lysine 4, two post translational modifications of histones, occupying on the TSPY1 promoter, faciliated the TSPY1 expression in PCa cells.	acetyl-histone	4-18	testis specific protein Y-linked 1	Homo sapiens	128-133
33185915-4	2021	The acetyl-histone H4 and trimethylated histone H3-lysine 4, two post translational modifications of histones, occupying on the TSPY1 promoter, faciliated the TSPY1 expression in PCa cells.	acetyl-histone	4-18	testis specific protein Y-linked 1	Homo sapiens	159-164
29534174-2	2018	On the basis of genome-wide analyses using the chromatin immunoprecipitation-sequencing technique, we found that dual-specificity phosphatase 2 (Dusp2) had a significantly lower acetyl-histone status in Batf2-/- bone marrow-derived macrophages (BMDMs) compared with wild-type (WT) BMDMs.	acetyl-histone	178-192	dual specificity phosphatase 2	Mus musculus	113-143
30815722-3	2019	Downregulation of RALDH2 mRNA was caused by decreased binding of acetyl-histone H3 (Ac-H3) to the RALDH2 promoter.	acetyl-histone	65-79	aldehyde dehydrogenase 1 family member A2	Homo sapiens	18-24
30815722-3	2019	Downregulation of RALDH2 mRNA was caused by decreased binding of acetyl-histone H3 (Ac-H3) to the RALDH2 promoter.	acetyl-histone	65-79	aldehyde dehydrogenase 1 family member A2	Homo sapiens	98-104
30291224-10	2018	RhIL-17A increased the IKKalpha/acetyl-histone H3 immunoprecipitation in 16HBE cells.	acetyl-histone	32-46	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	23-31
30291224-11	2018	The anticholinergic drug affects TSLP protein and mRNA levels in bronchial epithelial cells treated with rhIL-17A or with ISs from COPD patients, and IKKalpha mediated acetyl-histone H3(Lys14).	acetyl-histone	168-182	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	150-158
30291224-12	2018	IL-17A/IKKalpha signaling induced the mechanism of chromatin remodeling associated with acetyl-histone H3(Lys14) and TSLP production in bronchial epithelial cells.	acetyl-histone	88-102	interleukin 17A	Homo sapiens	0-6
30291224-12	2018	IL-17A/IKKalpha signaling induced the mechanism of chromatin remodeling associated with acetyl-histone H3(Lys14) and TSLP production in bronchial epithelial cells.	acetyl-histone	88-102	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	7-15
29534174-2	2018	On the basis of genome-wide analyses using the chromatin immunoprecipitation-sequencing technique, we found that dual-specificity phosphatase 2 (Dusp2) had a significantly lower acetyl-histone status in Batf2-/- bone marrow-derived macrophages (BMDMs) compared with wild-type (WT) BMDMs.	acetyl-histone	178-192	basic leucine zipper transcription factor, ATF-like 2	Mus musculus	203-208
29776409-12	2018	The ChIP analysis demonstrated a significant decrease in acetyl-histone H4, which is associated with an increase in HDAC3 in the FGFR1 promoter.	acetyl-histone	57-71	fibroblast growth factor receptor 1	Homo sapiens	129-134
29534174-2	2018	On the basis of genome-wide analyses using the chromatin immunoprecipitation-sequencing technique, we found that dual-specificity phosphatase 2 (Dusp2) had a significantly lower acetyl-histone status in Batf2-/- bone marrow-derived macrophages (BMDMs) compared with wild-type (WT) BMDMs.	acetyl-histone	178-192	dual specificity phosphatase 2	Mus musculus	145-150
26108221-5	2015	ChIP for acetyl-histone H3, a marker of active gene transcription, and trimethyl-histone-H3-Lys27 (H3K27me3), a marker of gene repression, showed higher H3K27me3 binding to exon 5, 6, and 8 promoters in BDNF(Met/Met).	acetyl-histone	9-23	brain derived neurotrophic factor	Mus musculus	203-207
29069573-0	2018	Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos.	acetyl-histone	22-36	B cell leukemia/lymphoma 2	Mus musculus	51-56
29069573-8	2018	ChIP-qPCR assay revealed that ethanol exposure significantly decreased acetyl-histone H3 binding to the Bcl-2 promoter while supplementing with SFN reversed the ethanol-induced reduction in acetyl-histone H3 binding to the Bcl-2 promoter.	acetyl-histone	71-85	B cell leukemia/lymphoma 2	Mus musculus	104-109
29069573-8	2018	ChIP-qPCR assay revealed that ethanol exposure significantly decreased acetyl-histone H3 binding to the Bcl-2 promoter while supplementing with SFN reversed the ethanol-induced reduction in acetyl-histone H3 binding to the Bcl-2 promoter.	acetyl-histone	190-204	B cell leukemia/lymphoma 2	Mus musculus	223-228
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	acetyl-histone	204-218	MLLT3 super elongation complex subunit	Homo sapiens	44-47
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	acetyl-histone	204-218	ALL1	Homo sapiens	49-53
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	acetyl-histone	204-218	MLLT1 super elongation complex subunit	Homo sapiens	144-147
28630232-12	2017	Furthermore, H19 knockdown reversed oxygen-glucose deprivation-induced upregulation of HDAC1 and downregulation of acetyl-histone H3 and acetyl-histone H4.	acetyl-histone	115-129	H19, imprinted maternally expressed transcript	Mus musculus	13-16
28630232-12	2017	Furthermore, H19 knockdown reversed oxygen-glucose deprivation-induced upregulation of HDAC1 and downregulation of acetyl-histone H3 and acetyl-histone H4.	acetyl-histone	137-151	H19, imprinted maternally expressed transcript	Mus musculus	13-16
27281610-9	2016	Furthermore, the level of acetyl-histone H4 binding to the NR0B1 promoter increased, whereas the occupancy of H3K27me3 was lower in cancerous tissues than in non-cancerous tissues.	acetyl-histone	26-40	nuclear receptor subfamily 0 group B member 1	Homo sapiens	59-64
29776409-12	2018	The ChIP analysis demonstrated a significant decrease in acetyl-histone H4, which is associated with an increase in HDAC3 in the FGFR1 promoter.	acetyl-histone	57-71	histone deacetylase 3	Homo sapiens	116-121
29483155-4	2018	Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4.	acetyl-histone	57-71	TOPBP1 interacting checkpoint and replication regulator	Homo sapiens	21-26
29483155-4	2018	Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4.	acetyl-histone	57-71	bromodomain containing 2	Homo sapiens	131-135
29483155-4	2018	Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4.	acetyl-histone	57-71	bromodomain containing 4	Homo sapiens	140-144
27451123-1	2016	BET proteins have recently become recognized for their role in a broad range of cancers and are defined by the presence of two acetyl-histone reading bromodomains and an ET domain.	acetyl-histone	127-141	delta/notch like EGF repeat containing	Homo sapiens	0-3
27451123-5	2016	BET inhibitors are acetyl-histone mimetics that specifically bind BET bromodomains, competitively inhibiting its engagement with chromatin.	acetyl-histone	19-33	delta/notch like EGF repeat containing	Homo sapiens	0-3
27451123-5	2016	BET inhibitors are acetyl-histone mimetics that specifically bind BET bromodomains, competitively inhibiting its engagement with chromatin.	acetyl-histone	19-33	delta/notch like EGF repeat containing	Homo sapiens	66-69
26023078-9	2015	The decreased level of RALDH2 mRNA in MMD ECFCs was attributed to defective acetyl-histone H3 binding to the promoter region.	acetyl-histone	76-90	aldehyde dehydrogenase 1 family member A2	Homo sapiens	23-29
24603592-8	2014	Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes.	acetyl-histone	119-133	brain-derived neurotrophic factor	Rattus norvegicus	174-178
24603592-8	2014	Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes.	acetyl-histone	137-151	brain-derived neurotrophic factor	Rattus norvegicus	174-178
21837748-8	2011	Through targeting HDAC4, miR-200a also induced the up-regulation of total acetyl-histone H3 levels and increased the histone H3 acetylation level at the p21(WAF/Cip1) promoter.	acetyl-histone	74-88	histone deacetylase 4	Homo sapiens	18-23
23759592-8	2013	Moreover, acetyl-histone H3 is significantly enriched at miR-34a promoter in IR-exposed HMEC cells.	acetyl-histone	10-24	microRNA 34a	Homo sapiens	57-64
21412773-8	2012	The Chromatin immuno-precipitation assay indicated that acetyl-Histone H3 and acetyl-Histone H4 associated with the IGF-IIR promoter increased in the presence of ANGII, otherwise methyl-CpG binding domain protein 2 (MeCP2) is disassociated with this.	acetyl-histone	56-70	insulin-like growth factor 2 receptor	Rattus norvegicus	116-123
21412773-8	2012	The Chromatin immuno-precipitation assay indicated that acetyl-Histone H3 and acetyl-Histone H4 associated with the IGF-IIR promoter increased in the presence of ANGII, otherwise methyl-CpG binding domain protein 2 (MeCP2) is disassociated with this.	acetyl-histone	56-70	angiotensinogen	Rattus norvegicus	162-167
21412773-8	2012	The Chromatin immuno-precipitation assay indicated that acetyl-Histone H3 and acetyl-Histone H4 associated with the IGF-IIR promoter increased in the presence of ANGII, otherwise methyl-CpG binding domain protein 2 (MeCP2) is disassociated with this.	acetyl-histone	78-92	insulin-like growth factor 2 receptor	Rattus norvegicus	116-123
21412773-8	2012	The Chromatin immuno-precipitation assay indicated that acetyl-Histone H3 and acetyl-Histone H4 associated with the IGF-IIR promoter increased in the presence of ANGII, otherwise methyl-CpG binding domain protein 2 (MeCP2) is disassociated with this.	acetyl-histone	78-92	angiotensinogen	Rattus norvegicus	162-167
21837748-8	2011	Through targeting HDAC4, miR-200a also induced the up-regulation of total acetyl-histone H3 levels and increased the histone H3 acetylation level at the p21(WAF/Cip1) promoter.	acetyl-histone	74-88	microRNA 200a	Homo sapiens	25-33
18211287-8	2008	Chromatin immunoprecipitation showed that accumulation of acetyl-histone H3 and release of HDAC1 were correlated with ID1 induction by these drugs.	acetyl-histone	58-72	inhibitor of DNA binding 1, HLH protein	Homo sapiens	118-121
17158602-10	2007	In contrast, p300, acetyl-histone (H3), and NF-kappaB p65 were found to be coimmunoprecipitated with the phosphorylated Akt, indicating that these components associated with the MMP-9 promoter are revealed by chromatin immunoprecipitation assay.	acetyl-histone	19-33	AKT serine/threonine kinase 1	Homo sapiens	120-123
17158602-10	2007	In contrast, p300, acetyl-histone (H3), and NF-kappaB p65 were found to be coimmunoprecipitated with the phosphorylated Akt, indicating that these components associated with the MMP-9 promoter are revealed by chromatin immunoprecipitation assay.	acetyl-histone	19-33	matrix metallopeptidase 9	Homo sapiens	178-183
12620225-3	2003	Here we show that yeast Bdf1 bromodomains recognize endogenous acetyl-histone H3/H4 as a mechanism for chromatin association in vivo.	acetyl-histone	63-77	chromatin-binding protein BDF1	Saccharomyces cerevisiae S288C	24-28
18582446-4	2008	Vehicle-treated TBI rats exhibited a significant reduction in acetyl-histone H3 immunostaining in the ipsilateral CA2/3 hippocampus compared to the sham TBI group (p<0.05).	acetyl-histone	62-76	carbonic anhydrase 2	Rattus norvegicus	114-117
15832170-6	2005	The match between the specificity of acetyl-histone deacetylation by HDAC3 and the histone-binding preference of N-CoR/SMRT allows the co-repressor complex to stabilize and propagate repression of nuclear hormone receptor gene targets.	acetyl-histone	37-51	histone deacetylase 3	Homo sapiens	69-74
15832170-6	2005	The match between the specificity of acetyl-histone deacetylation by HDAC3 and the histone-binding preference of N-CoR/SMRT allows the co-repressor complex to stabilize and propagate repression of nuclear hormone receptor gene targets.	acetyl-histone	37-51	nuclear receptor corepressor 1	Homo sapiens	113-118
15832170-6	2005	The match between the specificity of acetyl-histone deacetylation by HDAC3 and the histone-binding preference of N-CoR/SMRT allows the co-repressor complex to stabilize and propagate repression of nuclear hormone receptor gene targets.	acetyl-histone	37-51	nuclear receptor corepressor 2	Homo sapiens	119-123